Guide to the Human Genome
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Search of human proteins with 41582239

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41582239 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
         (428 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41582239 immunoglobulin superfamily containing leucine-rich r...   874   0.0  
gi|5031809 immunoglobulin superfamily containing leucine-rich re...   874   0.0  
gi|194306623 immunoglobulin superfamily containing leucine-rich ...   383   e-106
gi|194306621 immunoglobulin superfamily containing leucine-rich ...   383   e-106
gi|39930401 immunoglobulin superfamily containing leucine-rich r...   383   e-106
gi|194306618 immunoglobulin superfamily containing leucine-rich ...   383   e-106
gi|4759146 slit homolog 2 [Homo sapiens]                              120   3e-27
gi|109150416 peroxidasin [Homo sapiens]                               119   4e-27
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho...   119   4e-27
gi|188528675 slit homolog 1 [Homo sapiens]                            117   3e-26
gi|11321571 slit homolog 3 [Homo sapiens]                             114   2e-25
gi|27363458 leucine rich repeat and fibronectin type III domain ...   113   3e-25
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho...   111   1e-24
gi|14149694 retina specific protein PAL [Homo sapiens]                110   2e-24
gi|13375646 leucine rich repeat and fibronectin type III domain ...   107   2e-23
gi|126517478 peroxidasin homolog-like [Homo sapiens]                  107   2e-23
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...   102   5e-22
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]             102   7e-22
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]             102   7e-22
gi|61966761 leucine rich repeat containing 26 [Homo sapiens]          101   1e-21
gi|139948432 adlican [Homo sapiens]                                   100   3e-21
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]    99   6e-21
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]             99   6e-21
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]             99   6e-21
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]             99   6e-21
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]          99   7e-21
gi|157694513 leucine-rich repeat-containing G protein-coupled re...    98   2e-20
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]          96   5e-20
gi|239752702 PREDICTED: leucine rich repeat containing 38, parti...    96   6e-20
gi|31542244 leucine rich repeat and fibronectin type III domain ...    96   8e-20

>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score =  874 bits (2257), Expect = 0.0
 Identities = 428/428 (100%), Positives = 428/428 (100%)

Query: 1   MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN 60
           MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN
Sbjct: 1   MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN 60

Query: 61  RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN 120
           RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN
Sbjct: 61  RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN 120

Query: 121 LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180
           LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN
Sbjct: 121 LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180

Query: 181 PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP 240
           PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP
Sbjct: 181 PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP 240

Query: 241 SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS 300
           SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS
Sbjct: 241 SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS 300

Query: 301 QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH 360
           QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH
Sbjct: 301 QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH 360

Query: 361 GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL 420
           GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL
Sbjct: 361 GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL 420

Query: 421 LFFFLTSF 428
           LFFFLTSF
Sbjct: 421 LFFFLTSF 428


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score =  874 bits (2257), Expect = 0.0
 Identities = 428/428 (100%), Positives = 428/428 (100%)

Query: 1   MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN 60
           MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN
Sbjct: 1   MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN 60

Query: 61  RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN 120
           RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN
Sbjct: 61  RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN 120

Query: 121 LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180
           LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN
Sbjct: 121 LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180

Query: 181 PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP 240
           PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP
Sbjct: 181 PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP 240

Query: 241 SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS 300
           SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS
Sbjct: 241 SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS 300

Query: 301 QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH 360
           QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH
Sbjct: 301 QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH 360

Query: 361 GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL 420
           GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL
Sbjct: 361 GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL 420

Query: 421 LFFFLTSF 428
           LFFFLTSF
Sbjct: 421 LFFFLTSF 428


>gi|194306623 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  383 bits (983), Expect = e-106
 Identities = 217/426 (50%), Positives = 260/426 (61%), Gaps = 50/426 (11%)

Query: 1   MQELHLLW--WALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLS 58
           M  L  LW  WALL G+A +CPEPC C +KY  Q ADCAY++L  VP G PANVTTLSLS
Sbjct: 1   MFPLRALWLVWALL-GVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLS 59

Query: 59  ANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDL 118
           AN++  L  GAF +V  + SLWLAHNE+RTV  GALA LS LK+LDLSHN IS F WSDL
Sbjct: 60  ANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDL 119

Query: 119 HNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQIN 178
            NLSALQLLKM+ N L  +PRDA  +L  LRSL++N+NRL TLA GTF  L+ALSHLQ+ 
Sbjct: 120 RNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLY 179

Query: 179 ENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSY 238
            NPF C CG+VWL+ WA +T VS+PE D+IAC SP  L+G P+ RLP LPC+ PSV LS 
Sbjct: 180 HNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSA 239

Query: 239 QPSQD--GAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSP-------NVGT-- 287
           +P  +  G  LR G    LHC  DG P P+L W +QIP G V +  P        VG   
Sbjct: 240 EPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEE 299

Query: 288 -----DGRAL-----------PGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATN 331
                DG  L           P  P   + PRF A ANGSLL+P     E G Y+C A N
Sbjct: 300 GEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHN 359

Query: 332 ELGSAESSVDVALA-------TPGEGGE-----DTLGRRFHGKAVEGKGCYTVDNEVQPS 379
           ELG+  +S+ VA+A        PG GGE      T  R+      +G+G     N V PS
Sbjct: 360 ELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERK---STAKGRG-----NSVLPS 411

Query: 380 GPEDNV 385
            PE  +
Sbjct: 412 KPEGKI 417


>gi|194306621 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  383 bits (983), Expect = e-106
 Identities = 217/426 (50%), Positives = 260/426 (61%), Gaps = 50/426 (11%)

Query: 1   MQELHLLW--WALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLS 58
           M  L  LW  WALL G+A +CPEPC C +KY  Q ADCAY++L  VP G PANVTTLSLS
Sbjct: 1   MFPLRALWLVWALL-GVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLS 59

Query: 59  ANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDL 118
           AN++  L  GAF +V  + SLWLAHNE+RTV  GALA LS LK+LDLSHN IS F WSDL
Sbjct: 60  ANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDL 119

Query: 119 HNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQIN 178
            NLSALQLLKM+ N L  +PRDA  +L  LRSL++N+NRL TLA GTF  L+ALSHLQ+ 
Sbjct: 120 RNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLY 179

Query: 179 ENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSY 238
            NPF C CG+VWL+ WA +T VS+PE D+IAC SP  L+G P+ RLP LPC+ PSV LS 
Sbjct: 180 HNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSA 239

Query: 239 QPSQD--GAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSP-------NVGT-- 287
           +P  +  G  LR G    LHC  DG P P+L W +QIP G V +  P        VG   
Sbjct: 240 EPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEE 299

Query: 288 -----DGRAL-----------PGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATN 331
                DG  L           P  P   + PRF A ANGSLL+P     E G Y+C A N
Sbjct: 300 GEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHN 359

Query: 332 ELGSAESSVDVALA-------TPGEGGE-----DTLGRRFHGKAVEGKGCYTVDNEVQPS 379
           ELG+  +S+ VA+A        PG GGE      T  R+      +G+G     N V PS
Sbjct: 360 ELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERK---STAKGRG-----NSVLPS 411

Query: 380 GPEDNV 385
            PE  +
Sbjct: 412 KPEGKI 417


>gi|39930401 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  383 bits (983), Expect = e-106
 Identities = 217/426 (50%), Positives = 260/426 (61%), Gaps = 50/426 (11%)

Query: 1   MQELHLLW--WALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLS 58
           M  L  LW  WALL G+A +CPEPC C +KY  Q ADCAY++L  VP G PANVTTLSLS
Sbjct: 1   MFPLRALWLVWALL-GVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLS 59

Query: 59  ANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDL 118
           AN++  L  GAF +V  + SLWLAHNE+RTV  GALA LS LK+LDLSHN IS F WSDL
Sbjct: 60  ANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDL 119

Query: 119 HNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQIN 178
            NLSALQLLKM+ N L  +PRDA  +L  LRSL++N+NRL TLA GTF  L+ALSHLQ+ 
Sbjct: 120 RNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLY 179

Query: 179 ENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSY 238
            NPF C CG+VWL+ WA +T VS+PE D+IAC SP  L+G P+ RLP LPC+ PSV LS 
Sbjct: 180 HNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSA 239

Query: 239 QPSQD--GAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSP-------NVGT-- 287
           +P  +  G  LR G    LHC  DG P P+L W +QIP G V +  P        VG   
Sbjct: 240 EPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEE 299

Query: 288 -----DGRAL-----------PGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATN 331
                DG  L           P  P   + PRF A ANGSLL+P     E G Y+C A N
Sbjct: 300 GEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHN 359

Query: 332 ELGSAESSVDVALA-------TPGEGGE-----DTLGRRFHGKAVEGKGCYTVDNEVQPS 379
           ELG+  +S+ VA+A        PG GGE      T  R+      +G+G     N V PS
Sbjct: 360 ELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERK---STAKGRG-----NSVLPS 411

Query: 380 GPEDNV 385
            PE  +
Sbjct: 412 KPEGKI 417


>gi|194306618 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  383 bits (983), Expect = e-106
 Identities = 217/426 (50%), Positives = 260/426 (61%), Gaps = 50/426 (11%)

Query: 1   MQELHLLW--WALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLS 58
           M  L  LW  WALL G+A +CPEPC C +KY  Q ADCAY++L  VP G PANVTTLSLS
Sbjct: 1   MFPLRALWLVWALL-GVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLS 59

Query: 59  ANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDL 118
           AN++  L  GAF +V  + SLWLAHNE+RTV  GALA LS LK+LDLSHN IS F WSDL
Sbjct: 60  ANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDL 119

Query: 119 HNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQIN 178
            NLSALQLLKM+ N L  +PRDA  +L  LRSL++N+NRL TLA GTF  L+ALSHLQ+ 
Sbjct: 120 RNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLY 179

Query: 179 ENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSY 238
            NPF C CG+VWL+ WA +T VS+PE D+IAC SP  L+G P+ RLP LPC+ PSV LS 
Sbjct: 180 HNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSA 239

Query: 239 QPSQD--GAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSP-------NVGT-- 287
           +P  +  G  LR G    LHC  DG P P+L W +QIP G V +  P        VG   
Sbjct: 240 EPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEE 299

Query: 288 -----DGRAL-----------PGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATN 331
                DG  L           P  P   + PRF A ANGSLL+P     E G Y+C A N
Sbjct: 300 GEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHN 359

Query: 332 ELGSAESSVDVALA-------TPGEGGE-----DTLGRRFHGKAVEGKGCYTVDNEVQPS 379
           ELG+  +S+ VA+A        PG GGE      T  R+      +G+G     N V PS
Sbjct: 360 ELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERK---STAKGRG-----NSVLPS 411

Query: 380 GPEDNV 385
            PE  +
Sbjct: 412 KPEGKI 417


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score =  120 bits (300), Expect = 3e-27
 Identities = 68/206 (33%), Positives = 104/206 (50%), Gaps = 7/206 (3%)

Query: 19  CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78
           CP  C C       I DC  + L  +P   P  +T + L  N +  +P GAF     L+ 
Sbjct: 273 CPAACTCSNN----IVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRR 328

Query: 79  LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138
           + L++N+I  +A  A   L  L SL L  N I++   S    L +LQLL +++N++  + 
Sbjct: 329 IDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLR 388

Query: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTT 198
            DAF+ L  L  L L  N+L T+A+GTF+PL A+  + + +NPF C C + WL  +  T 
Sbjct: 389 VDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTN 448

Query: 199 AVSIPEQDNIACTSPHVLKGTPLSRL 224
            +   E     CTSP  L    + ++
Sbjct: 449 PI---ETSGARCTSPRRLANKRIGQI 471



 Score =  101 bits (252), Expect = 1e-21
 Identities = 61/205 (29%), Positives = 97/205 (47%), Gaps = 8/205 (3%)

Query: 18  ACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPE-GAFREVPLL 76
           ACPE C C         DC+ + L  +P   P     L L+ N    L   G F+++P L
Sbjct: 505 ACPEKCRCEGT----TVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQL 560

Query: 77  QSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTF 136
           + +  ++N+I  +  GA    S +  + L+ N + +        L +L+ L + SN +T 
Sbjct: 561 RKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITC 620

Query: 137 IPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWAL 196
           +  D+F  L ++R L L  N++ T+A G F  L +LS L +  NPF+C C + WL  W  
Sbjct: 621 VGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLR 680

Query: 197 TTAVSIPEQDNIACTSPHVLKGTPL 221
              +      N  C  P+ LK  P+
Sbjct: 681 KKRI---VTGNPRCQKPYFLKEIPI 702



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 55/176 (31%), Positives = 80/176 (45%), Gaps = 29/176 (16%)

Query: 19  CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78
           CP  C C +     +  C+ + L+ +P G P +VT L L  N+   +P+           
Sbjct: 727 CPTECTCLDT----VVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK----------- 771

Query: 79  LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138
                          L++  HL  +DLS+N IS  +     N++ L  L +  N L  IP
Sbjct: 772 --------------ELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIP 817

Query: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTW 194
              F  L++LR L L+ N +  + EG F  L+ALSHL I  NP  C C + WL  W
Sbjct: 818 PRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDW 873



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 57/202 (28%), Positives = 83/202 (41%), Gaps = 28/202 (13%)

Query: 17  QACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLL 76
           QACP  C C         DC    L SVP   P N   L L+ N +  + +  F  +  L
Sbjct: 26  QACPAQCSCSGS----TVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHL 81

Query: 77  QSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTF 136
           + L L  N+I T+  GA   L  L+ L L+ N +  F        + L  L +  N++  
Sbjct: 82  RVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQA 141

Query: 137 IPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFD------------- 183
           IPR AFR    +++LQL++N++  + +G F  L  L  L +N N                
Sbjct: 142 IPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKL 201

Query: 184 -----------CTCGIVWLKTW 194
                      C C + WL  W
Sbjct: 202 RTFRLHSNNLYCDCHLAWLSDW 223


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score =  119 bits (299), Expect = 4e-27
 Identities = 88/334 (26%), Positives = 149/334 (44%), Gaps = 31/334 (9%)

Query: 9   WALLLGLAQ----ACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPG 64
           W  L  +AQ     CP  C C          C +  LE+VP   P   + L L  NR+  
Sbjct: 22  WGTLAVVAQKPGAGCPSRCLCFRT----TVRCMHLLLEAVPAVAP-QTSILDLRFNRIRE 76

Query: 65  LPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSAL 124
           +  GAFR +  L +L L +N+I+ + +GA   L +LK L L  N I          L++L
Sbjct: 77  IQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASL 136

Query: 125 QLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDC 184
           + L +  N++  +  D+F+ L  L  L L++NR+  L  GTF  L ++  L+++ N   C
Sbjct: 137 EQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHC 196

Query: 185 TCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQDG 244
            C I+WL     T A S   Q    C  P  ++G  ++ + P   +    +++ +P    
Sbjct: 197 DCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQD-- 254

Query: 245 AELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRF 304
           A++  G  +   C  +G P P++ W       +      ++ TD              R 
Sbjct: 255 ADVTSGNTVYFTCRAEGNPKPEIIW-------LRNNNELSMKTDS-------------RL 294

Query: 305 QAFANGSLLIPDFGKLEEGTYSCLATNELGSAES 338
               +G+L+I +  + ++G Y C+A N  G  ++
Sbjct: 295 NLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKT 328



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 82/386 (21%), Positives = 141/386 (36%), Gaps = 106/386 (27%)

Query: 33  IADCAYRDLESVPPGF---PANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTV 89
           I D  +  +  + PG      N+ TL L+ N++  +P GAF ++  L+ L+L  NEI+++
Sbjct: 66  ILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSI 125

Query: 90  ---AAGALASLS------------------HLKSLD---LSHNLISDFAWSDLHNLSALQ 125
              A   LASL                   HL  L+   L +N I+       ++L +++
Sbjct: 126 DRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMK 185

Query: 126 LLKMDSNEL----------------------------TFIPRDAFRSLRALRSLQLNHNR 157
            L++DSN L                             +  R   RS+  +   +LN  R
Sbjct: 186 RLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCER 245

Query: 158 LHTLAEGTFTPLTALSHLQINENPFDCTCG------IVWLKTWALTTAVSIPEQDNIACT 211
               +E     +T+ + +      F C         I+WL+      ++    + N+   
Sbjct: 246 PRITSEPQDADVTSGNTVY-----FTCRAEGNPKPEIIWLRN-NNELSMKTDSRLNLLDD 299

Query: 212 SPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQD-----GAELRPGFVL------------- 253
              +++ T  +      C A +V    +  +      G+  RP FV+             
Sbjct: 300 GTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESV 359

Query: 254 ALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLL 313
            L C   G P P++ W                 T G   P  PV    PR     +G L 
Sbjct: 360 TLECSATGHPPPRISW-----------------TRGDRTP-LPV---DPRVNITPSGGLY 398

Query: 314 IPDFGKLEEGTYSCLATNELGSAESS 339
           I +  + + G Y+C ATN + S  ++
Sbjct: 399 IQNVVQGDSGEYACSATNNIDSVHAT 424



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 35/157 (22%), Positives = 58/157 (36%), Gaps = 39/157 (24%)

Query: 198 TAVSIPEQDNIACTSPHVLKG-------TPLSRLPPLPCSAPSVQLSYQPSQDGAELRPG 250
           + V++ +Q    C + +++         T   R+ P+  S PS             +  G
Sbjct: 490 SGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPS----------DTTVEVG 539

Query: 251 FVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANG 310
             + L C   G+P P + W+                       G  V  S  +F     G
Sbjct: 540 ANVQLPCSSQGEPEPAITWNKD---------------------GVQVTESG-KFHISPEG 577

Query: 311 SLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATP 347
            L I D G  + G Y C+A N +GSA  S+ +++  P
Sbjct: 578 FLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVP 614


>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
           sapiens]
          Length = 345

 Score =  119 bits (299), Expect = 4e-27
 Identities = 81/269 (30%), Positives = 121/269 (44%), Gaps = 16/269 (5%)

Query: 11  LLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAF 70
           +LL +  +CP+ C C     F   DC+ + L  +P   P    TL L  N++  LP  AF
Sbjct: 13  VLLQVVCSCPDKCYCQSSTNF--VDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAF 70

Query: 71  REVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMD 130
           R VP L +L L++N +  +A GA   L HL+ L+L+ N +        H+L  L+ L + 
Sbjct: 71  RSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLS 130

Query: 131 SNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVW 190
           SN ++ +P     +   L  L +  N+L  L       + ++  L + +N + C C ++ 
Sbjct: 131 SNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLG 190

Query: 191 LKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLP-----PLPCSAP---SVQLSYQPSQ 242
           LK W           D I C SP   KG  L R+P     P P  AP   S Q  +  S 
Sbjct: 191 LKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSA 250

Query: 243 DGAELRP------GFVLALHCDVDGQPAP 265
            G  LRP      G    L C++  +P P
Sbjct: 251 HGVVLRPPENHNAGERELLECELKPKPRP 279


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  117 bits (292), Expect = 3e-26
 Identities = 68/207 (32%), Positives = 103/207 (49%), Gaps = 7/207 (3%)

Query: 18  ACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQ 77
           +CP  C C       I DC  + L ++P   P  +T + L  N +  +P GAF     L+
Sbjct: 281 SCPAMCTCSNG----IVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLR 336

Query: 78  SLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFI 137
            + L++N+I  +A  A   L  L SL L  N I+D        L  LQLL +++N++  I
Sbjct: 337 RIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCI 396

Query: 138 PRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALT 197
             DAF+ L+ L  L L  N++ +LA+GTFT L A+  L + +NPF C C + WL  +  T
Sbjct: 397 RPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRT 456

Query: 198 TAVSIPEQDNIACTSPHVLKGTPLSRL 224
             +   E     C SP  L    + ++
Sbjct: 457 NPI---ETSGARCASPRRLANKRIGQI 480



 Score =  107 bits (267), Expect = 2e-23
 Identities = 70/216 (32%), Positives = 98/216 (45%), Gaps = 34/216 (15%)

Query: 19  CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78
           CP+ C C +     +  C+ + L ++P G P NVT L L  N+                 
Sbjct: 734 CPQECACLDT----VVRCSNKHLRALPKGIPKNVTELYLDGNQF---------------- 773

Query: 79  LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138
                    T+  G L++  +L+ +DLS+N IS  + S   N+S L  L +  N L  IP
Sbjct: 774 ---------TLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIP 824

Query: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTT 198
             AF+ LR+LR L L+ N + TL EG F  +T+LSHL I  NP  C C + WL +W  T 
Sbjct: 825 PLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKT- 883

Query: 199 AVSIPEQDNIACTSPHVLKGTPLSRLP--PLPCSAP 232
                E     C  P  ++G  L   P     C  P
Sbjct: 884 --GYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGP 917



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 56/204 (27%), Positives = 95/204 (46%), Gaps = 8/204 (3%)

Query: 19  CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPE-GAFREVPLLQ 77
           CP  C C       + +C+   L  +P   P +   L L+ N +  L   G F+++  L+
Sbjct: 513 CPHKCRCEAN----VVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLK 568

Query: 78  SLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFI 137
            + L++N++  +  GA    + +  L L+ N +          L  L+ L + +N ++ I
Sbjct: 569 KINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCI 628

Query: 138 PRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALT 197
             D+F  LR +R L L  N++ T++ G F  L +LS L +  NPF+C C + WL  W   
Sbjct: 629 HNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRK 688

Query: 198 TAVSIPEQDNIACTSPHVLKGTPL 221
             +      N  C +P  L+  PL
Sbjct: 689 RKI---VTGNPRCQNPDFLRQIPL 709



 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 64/217 (29%), Positives = 88/217 (40%), Gaps = 29/217 (13%)

Query: 3   ELHLLWWALLLGL-AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANR 61
           EL LL WA    L A ACP  C C         DC    L+++P   P N   L L+ N 
Sbjct: 17  ELWLLLWAAAWRLGASACPALCTCTGT----TVDCHGTGLQAIPKNIPRNTERLELNGNN 72

Query: 62  LPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNL 121
           +  + +  F  +  L+ L L  N+I  V  GA   +  L+ L L+ N +         N 
Sbjct: 73  ITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNN 132

Query: 122 SALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENP 181
            AL  L +  N +  IPR AFR    L++LQL+ N++  + EG F  L  L  L +N N 
Sbjct: 133 QALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNN 192

Query: 182 FD------------------------CTCGIVWLKTW 194
                                     C C + WL  W
Sbjct: 193 ITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQW 229


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score =  114 bits (284), Expect = 2e-25
 Identities = 62/207 (29%), Positives = 103/207 (49%), Gaps = 7/207 (3%)

Query: 18  ACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQ 77
           +CP PC C       I DC  + L  +P   P  +  + L  N +  +P GAF +   L+
Sbjct: 279 SCPSPCTCSNN----IVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLK 334

Query: 78  SLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFI 137
            + ++ N+I  +A  A   L  L SL L  N I++ A      L +LQLL +++N++  +
Sbjct: 335 RIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCL 394

Query: 138 PRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALT 197
             + F+ L+ L  L L  N+L T+++G F PL ++  L + +NPF C C + WL  +   
Sbjct: 395 RVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQD 454

Query: 198 TAVSIPEQDNIACTSPHVLKGTPLSRL 224
             +   E     C+SP  L    +S++
Sbjct: 455 NPI---ETSGARCSSPRRLANKRISQI 478



 Score =  107 bits (266), Expect = 3e-23
 Identities = 65/204 (31%), Positives = 99/204 (48%), Gaps = 8/204 (3%)

Query: 19  CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPE-GAFREVPLLQ 77
           CPE C C       I DC+ + L  +P   P  VT L L+ N +  L   G F+++P L+
Sbjct: 505 CPEKCRCEGT----IVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLR 560

Query: 78  SLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFI 137
            + L++N+I+ V  GA    + ++ L L+ N +          LS L+ L + SN +  +
Sbjct: 561 KINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCV 620

Query: 138 PRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALT 197
             D F  L ++R L L  NR+ T+  G FT L +LS + +  NPF+C C + WL  W   
Sbjct: 621 SNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRK 680

Query: 198 TAVSIPEQDNIACTSPHVLKGTPL 221
             +      N  C  P  LK  P+
Sbjct: 681 RRI---VSGNPRCQKPFFLKEIPI 701



 Score =  105 bits (261), Expect = 1e-22
 Identities = 70/220 (31%), Positives = 95/220 (43%), Gaps = 34/220 (15%)

Query: 15  LAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVP 74
           L+  CPE C C E     +  C+ + L ++P G P +VT L L  N L  +P        
Sbjct: 721 LSPRCPEQCTCMET----VVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPR------- 769

Query: 75  LLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNEL 134
                              L++L HL  +DLS+N IS        N+S L  L +  N L
Sbjct: 770 ------------------ELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRL 811

Query: 135 TFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTW 194
             IP  AF  LR+LR L L+ N + ++ EG+F  LT+LSHL +  NP  C C + WL  W
Sbjct: 812 RCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEW 871

Query: 195 ALTTAVSIPEQDNIACTSPHVLKGTPLSRLPP--LPCSAP 232
                    E     C+SP  +    L   P     C  P
Sbjct: 872 ---VKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGP 908



 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 54/203 (26%), Positives = 84/203 (41%), Gaps = 28/203 (13%)

Query: 16  AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPL 75
           A ACP  C C         DC    L +VP G P N   L L  N +  + +  F  +  
Sbjct: 31  AVACPTKCTCSAAS----VDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKN 86

Query: 76  LQSLWLAHNEIRTVAAGALASLSHLKSL------------------------DLSHNLIS 111
           L+ L L  N++  +  GA   L  L+ L                        DLS N I 
Sbjct: 87  LRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQ 146

Query: 112 DFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTA 171
                    ++ ++ L++D+N ++ I   AFR+LR L  L LN+N +  +   +F  +  
Sbjct: 147 GIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPK 206

Query: 172 LSHLQINENPFDCTCGIVWLKTW 194
           +  L+++ N   C C + WL  W
Sbjct: 207 IRTLRLHSNHLYCDCHLAWLSDW 229



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 22/71 (30%), Positives = 35/71 (49%)

Query: 127 LKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTC 186
           L +D N +T I +  F  L+ LR L L  N++  +  G F  L  L  L++N+N      
Sbjct: 66  LDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLP 125

Query: 187 GIVWLKTWALT 197
            +++  T  LT
Sbjct: 126 ELLFQSTPKLT 136


>gi|27363458 leucine rich repeat and fibronectin type III domain
           containing 4 [Homo sapiens]
          Length = 635

 Score =  113 bits (283), Expect = 3e-25
 Identities = 104/337 (30%), Positives = 140/337 (41%), Gaps = 59/337 (17%)

Query: 37  AYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALAS 96
           A+ DLES+         +L L  NRL  L  G+ R    LQ L L+ N++  +A GA   
Sbjct: 91  AFGDLESL--------RSLHLDGNRLVELGTGSLRGPVNLQHLILSGNQLGRIAPGAFDD 142

Query: 97  -LSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNH 155
            L  L+ LDLS+N +    W+ +  + AL  L +D N +  +P  AF  L  L  L L  
Sbjct: 143 FLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLSRLDLTS 202

Query: 156 NRLHTL-----------AEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPE 204
           NRL TL           AE +  PL     L  + NP  C C ++WL+  A         
Sbjct: 203 NRLATLAPDPLFSRGRDAEASPAPLV----LSFSGNPLHCNCELLWLRRLA-------RP 251

Query: 205 QDNIACTSPHVLKGTPLSRLP--PLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQ 262
            D   C SP  L G     +P     C  P +    Q       +  G    L C   G 
Sbjct: 252 DDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQ----RLWVLEGQRATLRCRALGD 307

Query: 263 PAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEE 322
           PAP +HW               VG D R      +  +  R +AF NG+L I   G  + 
Sbjct: 308 PAPTMHW---------------VGPDDR------LVGNSSRARAFPNGTLEIGVTGAGDA 346

Query: 323 GTYSCLATNELGSAESSVDV-ALATPGEGGEDTLGRR 358
           G Y+C+ATN  G A + V++  LA P  G     G R
Sbjct: 347 GGYTCIATNPAGEATARVELRVLALPHGGNSSAEGGR 383


>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
           sapiens]
          Length = 370

 Score =  111 bits (278), Expect = 1e-24
 Identities = 78/232 (33%), Positives = 110/232 (47%), Gaps = 4/232 (1%)

Query: 19  CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78
           CP  C C  +   ++ DC+   L +VPP  PA   TL L  N+L  LP  AF  +  LQ 
Sbjct: 39  CPFSCKCDSR-SLEV-DCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQR 96

Query: 79  LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138
           L L++N +  +       L++L  L L +N I       L +   L+ L +  N L  +P
Sbjct: 97  LDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLP 156

Query: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTT 198
              F  L ALRSL L  NRL  L   TF PL  L  LQ+ +NP++C C +   K W    
Sbjct: 157 PGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWF 216

Query: 199 AVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPG 250
           +      D +ACT P  L+G  + R+ P+       QL  + S  G ++ PG
Sbjct: 217 SYRGGRLDQLACTLPKELRGKDM-RMVPMEMFNYCSQLEDENSSAGLDI-PG 266


>gi|14149694 retina specific protein PAL [Homo sapiens]
          Length = 623

 Score =  110 bits (276), Expect = 2e-24
 Identities = 98/372 (26%), Positives = 146/372 (39%), Gaps = 56/372 (15%)

Query: 4   LHLLWWALLLGLAQA---CPEPCDC-----GEKYGFQIADCAYRDLESVPPGFPANVTTL 55
           L +LW   L    QA   CP  C C     G+    +   C   D+   P   P + + L
Sbjct: 5   LGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRL 64

Query: 56  SLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAW 115
            L    +  +P  AFR +  L+ LWL +N +  + A  L  L  L+ L L  N ++ F W
Sbjct: 65  RLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPW 124

Query: 116 SDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAE-----------G 164
           + L +   L+LL + +N L+ +P +A R L  L  L L+ N+L  L +           G
Sbjct: 125 AALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETG 184

Query: 165 TFTPLTALSH-----LQINENPFDCTCGIV----WLKTWALTTAVSIPEQDNIACTSPHV 215
            F P     H     L + +NP+ C C +      L  WA   A     +  + C SP  
Sbjct: 185 IFPP----GHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFI---ETELRCASPRS 237

Query: 216 LKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPS 275
           L G   S+L    C  P +     P         G    L C   G P P++ W      
Sbjct: 238 LAGVAFSQLELRKCQGPEL----HPGVASIRSLLGGTALLRCGATGVPGPEMSWR----- 288

Query: 276 GIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGS 335
                       +GR L GT     +      +   L +P    L+ G Y C A N LG+
Sbjct: 289 ----------RANGRPLNGT--VHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGA 336

Query: 336 AESSVDVALATP 347
           +E+ + + +  P
Sbjct: 337 SETVISLIVTEP 348


>gi|13375646 leucine rich repeat and fibronectin type III domain
           containing 3 [Homo sapiens]
          Length = 628

 Score =  107 bits (268), Expect = 2e-23
 Identities = 93/308 (30%), Positives = 129/308 (41%), Gaps = 48/308 (15%)

Query: 55  LSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSH-LKSLDLSHNLISDF 113
           L L  NRL  L EG  R +  L+ L L++N++  +AAGAL   +  L+ LDLS+N +   
Sbjct: 112 LHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQL 171

Query: 114 AWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHT------------L 161
            W  L  L  +  L +D N L  +P  AF  L  L  L +  NRL T            L
Sbjct: 172 PWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLL 231

Query: 162 AEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPL 221
           A    +P +AL  L    NP  C C +VWL+  A        E D  AC SP  L G   
Sbjct: 232 ARPRGSPASALV-LAFGGNPLHCNCELVWLRRLA-------REDDLEACASPPALGGRYF 283

Query: 222 SRL--PPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVE 279
             +      C  P V     P      +  G   AL C   G P P++ W          
Sbjct: 284 WAVGEEEFVCEPPVVTHRSPP----LAVPAGRPAALRCRAVGDPEPRVRW---------- 329

Query: 280 ITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESS 339
                V   GR L       +  R +AF NG+L +      + G ++C+A N  G A ++
Sbjct: 330 -----VSPQGRLL------GNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAA 378

Query: 340 VDVALATP 347
           V++ +  P
Sbjct: 379 VELTVGPP 386



 Score = 52.4 bits (124), Expect = 8e-07
 Identities = 30/78 (38%), Positives = 42/78 (53%)

Query: 103 LDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLA 162
           L L+ N I+     DL N++ L  L +  N +  +   AF  LRALR+L L+ NRL +L 
Sbjct: 64  LRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLG 123

Query: 163 EGTFTPLTALSHLQINEN 180
           EG    L  L HL ++ N
Sbjct: 124 EGQLRGLVNLRHLILSNN 141


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score =  107 bits (268), Expect = 2e-23
 Identities = 86/342 (25%), Positives = 142/342 (41%), Gaps = 33/342 (9%)

Query: 3   ELHLLWWALLLGLAQ------ACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLS 56
           E  L  W  L  LA        CP  C C +        C +  L+ +P   P   T L 
Sbjct: 2   EPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKS----TVRCMHLMLDHIPQ-VPQQTTVLD 56

Query: 57  LSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWS 116
           L  NR+  +P  AF+++  L +L L +N IR ++  A   L +L  L L  N I      
Sbjct: 57  LRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQ 116

Query: 117 DLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQ 176
               L +L+ L +  N+L  +  + F  L  L  L L++N+L  +  G+F+ L +L  L+
Sbjct: 117 TFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLR 176

Query: 177 INENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQL 236
           ++ N   C C ++WL       A     Q    C  P  L G  ++ +     +  S ++
Sbjct: 177 LDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRI 236

Query: 237 SYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTP 296
           +++P     E+  G  +   C  +G P P++ W              N   D        
Sbjct: 237 TFEPQD--VEVPSGNTVYFTCRAEGNPKPEIIW-----------IHNNHSLD-------- 275

Query: 297 VASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAES 338
                 R   F +G+L+I +  + ++G Y C+A N  G A++
Sbjct: 276 -LEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKT 316



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 27/116 (23%), Positives = 45/116 (38%), Gaps = 30/116 (25%)

Query: 233 SVQLSYQPSQ--------DGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPN 284
           SVQL+ +P              +  G  + + C   G+P P + W+ +     V+IT   
Sbjct: 500 SVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEG----VQITESG 555

Query: 285 VGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSV 340
                             +F     G+L I D G  ++G Y C+A N  G A +++
Sbjct: 556 ------------------KFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNM 593


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score =  102 bits (255), Expect = 5e-22
 Identities = 96/326 (29%), Positives = 139/326 (42%), Gaps = 61/326 (18%)

Query: 61  RLPGLPEGAFREVPLLQ-------------SLWLAHNEIRTVAAGALASLSHLKSLDLSH 107
           RLPGL        PLL+             SL + H  I  V A AL   +HL  L+LSH
Sbjct: 220 RLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSH 279

Query: 108 NLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFT 167
           N IS        +L  L+ L +    L  +   AF  LR +R L L++N L TL E TF 
Sbjct: 280 NPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFH 339

Query: 168 PLTALSHLQINENPFDCTCGIVWL--KTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLP 225
            +  L  L+++ NP  C C ++W+  +   L     +P     AC +P  ++G  L  LP
Sbjct: 340 SVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLP-----ACATPAEVRGDALRNLP 394

Query: 226 P------LPCSAPSV---QLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSG 276
                    C  P +   +L    +  G ++R        C  +G+PAP + W   +   
Sbjct: 395 DSVLFEYFVCRKPKIRERRLQRVTATAGEDVR------FLCRAEGEPAPTVAW---VTPQ 445

Query: 277 IVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGS- 335
              +T+ + G   R LPG               G+L I D    + GTY+C+A+N  G+ 
Sbjct: 446 HRPVTATSAGR-ARVLPG---------------GTLEIQDARPQDSGTYTCVASNAGGND 489

Query: 336 ---AESSV---DVALATPGEGGEDTL 355
              A  +V     A  TPGE   +TL
Sbjct: 490 TYFATLTVRPEPAANRTPGEAHNETL 515



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 60/189 (31%), Positives = 86/189 (45%), Gaps = 32/189 (16%)

Query: 16  AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANR-----------LPG 64
           A  CP  C+C  +   +   C  R L +VP G PA    L LS NR           LP 
Sbjct: 22  AGGCPARCECTVQT--RAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPA 79

Query: 65  LPE-------------GAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHN--- 108
           L E             GAF  +P L+ L L  N+++ +  G    L +L  LDLS N   
Sbjct: 80  LEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLV 139

Query: 109 LISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTP 168
           ++ D+ + DLH   +L+ L++  N+L F+ R AF  L AL  L L    L  L+  +   
Sbjct: 140 ILLDYTFQDLH---SLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGH 196

Query: 169 LTALSHLQI 177
           L +L  L++
Sbjct: 197 LRSLGALRL 205


>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  102 bits (254), Expect = 7e-22
 Identities = 94/332 (28%), Positives = 149/332 (44%), Gaps = 51/332 (15%)

Query: 32  QIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAA 91
           +I+D A   L+S+         +LS   N+L  +P  A  +VP L+ L L  N ++ V  
Sbjct: 227 EISDYALEGLQSLE--------SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGP 278

Query: 92  GALASLSHLKSLDLSHN----LISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRA 147
           G  A++ HLK L L++      I  FA  +L  L+ L +   ++  L+FI   AF  L  
Sbjct: 279 GDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDIT--NNPRLSFIHPRAFHHLPQ 336

Query: 148 LRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDN 207
           + +L LN+N L  L + T   L  L  + ++ NP  C C I W    A  T V   E  +
Sbjct: 337 METLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWAN--ATGTRVRFIEPQS 394

Query: 208 IACTSPHVLKGTPLSRLP-------PLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVD 260
             C  P  L+  P+  +P        LP  +P    S+ PS    ++  G  + LHC   
Sbjct: 395 TLCAEPPDLQRLPVREVPFREMTDHCLPLISPR---SFPPS---LQVASGESMVLHCRAL 448

Query: 261 GQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKL 320
            +P P+++W    P+G+  +T  + G                R++ +  G+L +      
Sbjct: 449 AEPEPEIYW--VTPAGL-RLTPAHAGR---------------RYRVYPEGTLELRRVTAE 490

Query: 321 EEGTYSCLATNELGSAESSVDV----ALATPG 348
           E G Y+C+A N +G+   +V V    AL  PG
Sbjct: 491 EAGLYTCVAQNLVGADTKTVSVVVGRALLQPG 522



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 55/171 (32%), Positives = 73/171 (42%), Gaps = 33/171 (19%)

Query: 19  CPEPCDCGEKYGFQ---------IADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGA 69
           CP  C C  +  +            DC    L +VPP  PA   TL              
Sbjct: 29  CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTL-------------- 74

Query: 70  FREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKM 129
                LLQS     N I  V    L  L++L  LDLS N  SD    D H L  L  L +
Sbjct: 75  -----LLQS-----NSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHL 124

Query: 130 DSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180
           + N+LT +   +F  L +L+ L LNHN+L+ +A   F+ L+ L  L +N N
Sbjct: 125 EENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSN 175



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 41/129 (31%), Positives = 60/129 (46%)

Query: 47  GFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLS 106
           G+ AN+T L LS N      +  F  +P L SL L  N++  +   + A L+ L+ L L+
Sbjct: 90  GYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLN 149

Query: 107 HNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTF 166
           HN +   A      LS L  L ++SN L  I    F  L  L  L +  N++  + +  F
Sbjct: 150 HNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNF 209

Query: 167 TPLTALSHL 175
            PL  L  L
Sbjct: 210 RPLANLRSL 218



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 4/129 (3%)

Query: 54  TLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLIS-- 111
           +L L  N+L  L + +F  +  LQ L+L HN++  +A  A + LS+L  L L+ NL+   
Sbjct: 121 SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI 180

Query: 112 DFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTA 171
           D  W ++  L  L++L +  N++  I    FR L  LRSL L    L  +++     L +
Sbjct: 181 DSRWFEM--LPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQS 238

Query: 172 LSHLQINEN 180
           L  L   +N
Sbjct: 239 LESLSFYDN 247



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 41/132 (31%), Positives = 66/132 (50%), Gaps = 6/132 (4%)

Query: 50  ANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH-N 108
           +N+  L L++N L  +    F  +P L+ L +  N++  +       L++L+SL L+  N
Sbjct: 165 SNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMN 224

Query: 109 L--ISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTF 166
           L  ISD+A   L  L +L+ L    N+L  +PR A   +  L+ L LN N L  +  G F
Sbjct: 225 LREISDYA---LEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDF 281

Query: 167 TPLTALSHLQIN 178
             +  L  L +N
Sbjct: 282 ANMLHLKELGLN 293


>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  102 bits (254), Expect = 7e-22
 Identities = 94/332 (28%), Positives = 149/332 (44%), Gaps = 51/332 (15%)

Query: 32  QIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAA 91
           +I+D A   L+S+         +LS   N+L  +P  A  +VP L+ L L  N ++ V  
Sbjct: 227 EISDYALEGLQSLE--------SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGP 278

Query: 92  GALASLSHLKSLDLSHN----LISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRA 147
           G  A++ HLK L L++      I  FA  +L  L+ L +   ++  L+FI   AF  L  
Sbjct: 279 GDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDIT--NNPRLSFIHPRAFHHLPQ 336

Query: 148 LRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDN 207
           + +L LN+N L  L + T   L  L  + ++ NP  C C I W    A  T V   E  +
Sbjct: 337 METLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWAN--ATGTRVRFIEPQS 394

Query: 208 IACTSPHVLKGTPLSRLP-------PLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVD 260
             C  P  L+  P+  +P        LP  +P    S+ PS    ++  G  + LHC   
Sbjct: 395 TLCAEPPDLQRLPVREVPFREMTDHCLPLISPR---SFPPS---LQVASGESMVLHCRAL 448

Query: 261 GQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKL 320
            +P P+++W    P+G+  +T  + G                R++ +  G+L +      
Sbjct: 449 AEPEPEIYW--VTPAGL-RLTPAHAGR---------------RYRVYPEGTLELRRVTAE 490

Query: 321 EEGTYSCLATNELGSAESSVDV----ALATPG 348
           E G Y+C+A N +G+   +V V    AL  PG
Sbjct: 491 EAGLYTCVAQNLVGADTKTVSVVVGRALLQPG 522



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 55/171 (32%), Positives = 73/171 (42%), Gaps = 33/171 (19%)

Query: 19  CPEPCDCGEKYGFQ---------IADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGA 69
           CP  C C  +  +            DC    L +VPP  PA   TL              
Sbjct: 29  CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTL-------------- 74

Query: 70  FREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKM 129
                LLQS     N I  V    L  L++L  LDLS N  SD    D H L  L  L +
Sbjct: 75  -----LLQS-----NSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHL 124

Query: 130 DSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180
           + N+LT +   +F  L +L+ L LNHN+L+ +A   F+ L+ L  L +N N
Sbjct: 125 EENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSN 175



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 41/129 (31%), Positives = 60/129 (46%)

Query: 47  GFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLS 106
           G+ AN+T L LS N      +  F  +P L SL L  N++  +   + A L+ L+ L L+
Sbjct: 90  GYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLN 149

Query: 107 HNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTF 166
           HN +   A      LS L  L ++SN L  I    F  L  L  L +  N++  + +  F
Sbjct: 150 HNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNF 209

Query: 167 TPLTALSHL 175
            PL  L  L
Sbjct: 210 RPLANLRSL 218



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 4/129 (3%)

Query: 54  TLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLIS-- 111
           +L L  N+L  L + +F  +  LQ L+L HN++  +A  A + LS+L  L L+ NL+   
Sbjct: 121 SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI 180

Query: 112 DFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTA 171
           D  W ++  L  L++L +  N++  I    FR L  LRSL L    L  +++     L +
Sbjct: 181 DSRWFEM--LPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQS 238

Query: 172 LSHLQINEN 180
           L  L   +N
Sbjct: 239 LESLSFYDN 247



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 41/132 (31%), Positives = 66/132 (50%), Gaps = 6/132 (4%)

Query: 50  ANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH-N 108
           +N+  L L++N L  +    F  +P L+ L +  N++  +       L++L+SL L+  N
Sbjct: 165 SNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMN 224

Query: 109 L--ISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTF 166
           L  ISD+A   L  L +L+ L    N+L  +PR A   +  L+ L LN N L  +  G F
Sbjct: 225 LREISDYA---LEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDF 281

Query: 167 TPLTALSHLQIN 178
             +  L  L +N
Sbjct: 282 ANMLHLKELGLN 293


>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
          Length = 334

 Score =  101 bits (251), Expect = 1e-21
 Identities = 71/207 (34%), Positives = 92/207 (44%), Gaps = 3/207 (1%)

Query: 16  AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPL 75
           A  CPE C C       +A C+   L +VPPG    +  L L  NR+  LP GAF     
Sbjct: 40  APDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGA 96

Query: 76  LQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELT 135
           LQ L L  N + +V   A   L  L+ LDLS N +   A      L AL+ L +  N L 
Sbjct: 97  LQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLA 156

Query: 136 FIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWA 195
            +   A  +L  LRSL L  N L  LA G    L AL  L +  NP+ C C +  L  W 
Sbjct: 157 RLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWL 216

Query: 196 LTTAVSIPEQDNIACTSPHVLKGTPLS 222
               +   E + + C  P  L  +PL+
Sbjct: 217 RRHPLPASEAETVLCVWPGRLTLSPLT 243


>gi|139948432 adlican [Homo sapiens]
          Length = 2828

 Score =  100 bits (249), Expect = 3e-21
 Identities = 75/262 (28%), Positives = 108/262 (41%), Gaps = 44/262 (16%)

Query: 15  LAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVP 74
           +A ACP PC C   Y      C +R L SVP G   +V  ++L  N +  L E +F  + 
Sbjct: 23  VALACPHPCAC---YVPSEVHCTFRSLASVPAGIAKHVERINLGFNSIQALSETSFAGLT 79

Query: 75  LLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNEL 134
            L+ L +  NEI ++  GAL  LS L+    S+N +       L  LS L  L +D N++
Sbjct: 80  KLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITGQTLQGLSNLMRLHIDHNKI 139

Query: 135 TFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLT------------------------ 170
            FI   AF  L +LR L L  N LH L   TF+  T                        
Sbjct: 140 EFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYFRLSTIRHLYLAENMVRTLP 199

Query: 171 --------ALSHLQINENPFDCTCGIVWLKTW-ALTTAVSIPEQDN--------IACTSP 213
                    L +L +  NP+ C C + W   W A +  +   ++D           C SP
Sbjct: 200 ASMLRNMPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGILKCKKDKAYEGGQLCAMCFSP 259

Query: 214 HVLKGTPLSRLPPLPCSAPSVQ 235
             L    + +L  + C  PS++
Sbjct: 260 KKLYKHEIHKLKDMTCLKPSIE 281



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 13/95 (13%)

Query: 253  LALHCDVDGQPAPQLHWHIQIPSG-IVEITSPNVGTDGRALPGTPVASSQPRFQAFANGS 311
            L + C   G P P++ W   +P G +V     +  + GR            R+  F NG+
Sbjct: 2261 LKVDCVATGLPNPEISW--SLPDGSLVNSFMQSDDSGGRT----------KRYVVFNNGT 2308

Query: 312  LLIPDFGKLEEGTYSCLATNELGSAESSVDVALAT 346
            L   + G  EEG Y+C A N++G  E  V V + T
Sbjct: 2309 LYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVT 2343



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 27/108 (25%), Positives = 41/108 (37%), Gaps = 23/108 (21%)

Query: 238  YQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPV 297
            +Q   +   L PG  + +HC     P P + W +                      GT +
Sbjct: 2050 HQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLG--------------------DGTQI 2089

Query: 298  ASSQ---PRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDV 342
              SQ        F NG+L I +    + G Y C+A N +GSA  +V +
Sbjct: 2090 RPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQL 2137



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 38/159 (23%), Positives = 60/159 (37%), Gaps = 34/159 (21%)

Query: 238  YQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPV 297
            + P  +      G  ++L+C   G P P L W +           PN         GT +
Sbjct: 2545 HDPISEKITAMAGHTISLNCSAAGTPTPSLVWVL-----------PN---------GTDL 2584

Query: 298  ASSQP--RFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGED-- 353
             S Q   RF   A+G L I     ++ G Y C+A N  G  E  V + +    E  +   
Sbjct: 2585 QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYH 2644

Query: 354  TLGRRFHGK----------AVEGKGCYTVDNEVQPSGPE 382
             L    +G+          A +G+  +T+ N +   GP+
Sbjct: 2645 NLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQ 2683



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 21/91 (23%), Positives = 40/91 (43%), Gaps = 20/91 (21%)

Query: 250  GFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFAN 309
            G V+ + C+  G+P P++ W               +    + +P     +S  ++Q + +
Sbjct: 2361 GDVVTVACEAKGEPMPKVTW---------------LSPTNKVIP-----TSSEKYQIYQD 2400

Query: 310  GSLLIPDFGKLEEGTYSCLATNELGSAESSV 340
            G+LLI    + + G Y+CL  N  G    +V
Sbjct: 2401 GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTV 2431



 Score = 38.1 bits (87), Expect = 0.015
 Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 17/89 (19%)

Query: 246  ELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQ 305
            ++R G  L L C   G P P++ W +     I                   + S   R +
Sbjct: 2157 DVRYGGTLKLDCSASGDPWPRILWRLPSKRMI-----------------DALFSFDSRIK 2199

Query: 306  AFANGSLLIPDFGKLEEGTYSCLATNELG 334
             FANG+L++      + G Y C+A N++G
Sbjct: 2200 VFANGTLVVKSVTDKDAGDYLCVARNKVG 2228



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 19/56 (33%), Positives = 28/56 (50%)

Query: 309 NGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFHGKAV 364
           NG+L IP     + G Y C+A N+ G+   +V + +   G G     GRR   KA+
Sbjct: 633 NGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRPGAKAL 688



 Score = 32.3 bits (72), Expect = 0.85
 Identities = 24/96 (25%), Positives = 39/96 (40%), Gaps = 17/96 (17%)

Query: 250  GFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFAN 309
            G  +A+ C   G PAPQ+ W I     + +  SP  G                R     N
Sbjct: 1965 GDTIAMECLAKGTPAPQISW-IFPDRRVWQTVSPVEG----------------RITLHEN 2007

Query: 310  GSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALA 345
             +L I +    + G Y C+A+N  G+   ++ + +A
Sbjct: 2008 RTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVA 2043



 Score = 32.3 bits (72), Expect = 0.85
 Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 18/95 (18%)

Query: 255  LHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLI 314
            + C  +G P P++ W    P G+V + +P  G                R     NGSL I
Sbjct: 2464 IDCKAEGIPTPRVLW--AFPEGVV-LPAPYYGN---------------RITVHGNGSLDI 2505

Query: 315  PDFGKLEEGTYSCLATNELGSAESSVDVALATPGE 349
                K +     C+A NE G A   + + +  P E
Sbjct: 2506 RSLRKSDSVQLVCMARNEGGEARLILQLTVLEPME 2540



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 20/75 (26%), Positives = 29/75 (38%), Gaps = 17/75 (22%)

Query: 257  CDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPD 316
            C+  G+P P + W               V T     P T +     RF+   NG+L+I  
Sbjct: 1875 CEATGKPKPFVTW-------------TKVSTGALMTPNTRIQ----RFEVLKNGTLVIRK 1917

Query: 317  FGKLEEGTYSCLATN 331
                + G Y C A+N
Sbjct: 1918 VQVQDRGQYMCTASN 1932



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 34/128 (26%), Positives = 48/128 (37%), Gaps = 24/128 (18%)

Query: 217  KGTPLSRLP----PLPCSAPSVQLSYQPSQDGAEL-----RPGFVLALHCDVDGQPAPQL 267
            +GT + R+     P   S P + ++Y P            RPG  + L+C   G P   +
Sbjct: 2706 RGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADI 2765

Query: 268  HWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSC 327
             W +   S +        G   R L G      Q        GSL I    + + G Y C
Sbjct: 2766 TWELPDKSHL------KAGVQAR-LYGNRFLHPQ--------GSLTIQHATQRDAGFYKC 2810

Query: 328  LATNELGS 335
            +A N LGS
Sbjct: 2811 MAKNILGS 2818


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 69/191 (36%), Positives = 90/191 (47%), Gaps = 3/191 (1%)

Query: 51  NVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLI 110
           N+T LSL  N L  LP G F   P L  L L HN++ TVA G  A LS+L+SL LS+N I
Sbjct: 266 NLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAI 325

Query: 111 SDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLT 170
           +        +L  L  L + SN LT +    F++L  L  L L+ N+L TL EG F    
Sbjct: 326 THLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNY 385

Query: 171 ALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKG--TPLSRLPPLP 228
            L +L ++ NP+ C C + +L  W L             C  P  LKG   P      L 
Sbjct: 386 NLFNLALHGNPWQCDCHLAYLFNW-LQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLV 444

Query: 229 CSAPSVQLSYQ 239
           C      L +Q
Sbjct: 445 CPVTRDHLGFQ 455



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 43/126 (34%), Positives = 71/126 (56%)

Query: 55  LSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFA 114
           L+L+ N L  LPEG F+ +  L+SL L  N+++ +       L+HLK+L+L+ NL++   
Sbjct: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185

Query: 115 WSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSH 174
               H L++LQ LK+ +N L+ +P+  F  L +L+ L L+ N +  L    F+ L  L  
Sbjct: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245

Query: 175 LQINEN 180
           L +  N
Sbjct: 246 LWLQRN 251



 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 47/130 (36%), Positives = 65/130 (50%)

Query: 51  NVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLI 110
           ++ TL LS N L GLP+G F ++  LQ L+L  N I  +     + L  L+ L L  N I
Sbjct: 194 SLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAI 253

Query: 111 SDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLT 170
           +    S   +L  L  L +  N L  +P   F     L  L L HN+L T+AEGTF  L+
Sbjct: 254 THLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLS 313

Query: 171 ALSHLQINEN 180
            L  L ++ N
Sbjct: 314 NLRSLMLSYN 323



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 58/201 (28%), Positives = 92/201 (45%), Gaps = 30/201 (14%)

Query: 6   LLWWALLLGL--AQACPEPCDCGEKYGFQIADCAYRDLESVP---PGFPANVTTLSLSAN 60
           LLW +LLL    AQ CP  CDC  +  F    C+  +L +VP   P +  N+  +  S  
Sbjct: 7   LLWTSLLLLARPAQPCPMGCDCFVQEVF----CSDEELATVPLDIPPYTKNIIFVETSFT 62

Query: 61  RL--------PGLPE-------------GAFREVPLLQSLWLAHNEIRTVAAGALASLSH 99
            L        P L +              AF  +P L+ L +  +    ++    ++L+ 
Sbjct: 63  TLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTS 122

Query: 100 LKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLH 159
           L  L L+ N++         +L+AL+ L +  N+L  +PR  F+ L  L++L L  N L 
Sbjct: 123 LGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLA 182

Query: 160 TLAEGTFTPLTALSHLQINEN 180
            L E  F PLT+L  L+++ N
Sbjct: 183 QLPEELFHPLTSLQTLKLSNN 203


>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 86/296 (29%), Positives = 136/296 (45%), Gaps = 29/296 (9%)

Query: 51  NVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH--N 108
           N+ ++S   NRL  +P  A ++V  L+ L L  N I  +  G  +++ HLK L +++   
Sbjct: 237 NLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPE 296

Query: 109 LISDFAWSDLHNLSALQLLKMDSN-ELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFT 167
           LIS  + + + NL  L+ ++  +N  L++I  +AF  L  L SL LN N L  L  GT  
Sbjct: 297 LISIDSLA-VDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIE 355

Query: 168 PLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRL--- 224
            L  L  + I+ NP  C C I W+      T +   E D++ C  P   +G  + ++   
Sbjct: 356 SLPNLKEISIHSNPIRCDCVIRWMN--MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFR 413

Query: 225 PPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPN 284
             +    P +     PS    E   G  ++ HC    +P P+++W    PSG  +   PN
Sbjct: 414 DMMEICLPLIAPESFPSNLNVE--AGSYVSFHCRATAEPQPEIYW--ITPSG--QKLLPN 467

Query: 285 VGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSV 340
             TD              +F   + G+L I      E G Y+C+ATN +G+   SV
Sbjct: 468 TLTD--------------KFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSV 509



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 55/176 (31%), Positives = 82/176 (46%), Gaps = 19/176 (10%)

Query: 48  FPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH 107
           FP N+T L LS N L  +     +++P L S++L  N++  +    L+ LS+L+ L ++H
Sbjct: 90  FPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINH 149

Query: 108 NLISDF---AWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEG 164
           NL+S     A+  LHNL  L L   +SN L  I    F +L  L  L +  N +  + + 
Sbjct: 150 NLLSTISPGAFIGLHNLLRLHL---NSNRLQMINSKWFDALPNLEILMIGENPIIRIKDM 206

Query: 165 TFTPLTALSHL-----QINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHV 215
            F PL  L  L      + E P +   G+  L+        SI   DN     PHV
Sbjct: 207 NFKPLINLRSLVIAGINLTEIPDNALVGLENLE--------SISFYDNRLIKVPHV 254


>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 86/296 (29%), Positives = 136/296 (45%), Gaps = 29/296 (9%)

Query: 51  NVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH--N 108
           N+ ++S   NRL  +P  A ++V  L+ L L  N I  +  G  +++ HLK L +++   
Sbjct: 237 NLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPE 296

Query: 109 LISDFAWSDLHNLSALQLLKMDSN-ELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFT 167
           LIS  + + + NL  L+ ++  +N  L++I  +AF  L  L SL LN N L  L  GT  
Sbjct: 297 LISIDSLA-VDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIE 355

Query: 168 PLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRL--- 224
            L  L  + I+ NP  C C I W+      T +   E D++ C  P   +G  + ++   
Sbjct: 356 SLPNLKEISIHSNPIRCDCVIRWMN--MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFR 413

Query: 225 PPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPN 284
             +    P +     PS    E   G  ++ HC    +P P+++W    PSG  +   PN
Sbjct: 414 DMMEICLPLIAPESFPSNLNVE--AGSYVSFHCRATAEPQPEIYW--ITPSG--QKLLPN 467

Query: 285 VGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSV 340
             TD              +F   + G+L I      E G Y+C+ATN +G+   SV
Sbjct: 468 TLTD--------------KFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSV 509



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 55/176 (31%), Positives = 82/176 (46%), Gaps = 19/176 (10%)

Query: 48  FPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH 107
           FP N+T L LS N L  +     +++P L S++L  N++  +    L+ LS+L+ L ++H
Sbjct: 90  FPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINH 149

Query: 108 NLISDF---AWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEG 164
           NL+S     A+  LHNL  L L   +SN L  I    F +L  L  L +  N +  + + 
Sbjct: 150 NLLSTISPGAFIGLHNLLRLHL---NSNRLQMINSKWFDALPNLEILMIGENPIIRIKDM 206

Query: 165 TFTPLTALSHL-----QINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHV 215
            F PL  L  L      + E P +   G+  L+        SI   DN     PHV
Sbjct: 207 NFKPLINLRSLVIAGINLTEIPDNALVGLENLE--------SISFYDNRLIKVPHV 254


>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 86/296 (29%), Positives = 136/296 (45%), Gaps = 29/296 (9%)

Query: 51  NVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH--N 108
           N+ ++S   NRL  +P  A ++V  L+ L L  N I  +  G  +++ HLK L +++   
Sbjct: 237 NLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPE 296

Query: 109 LISDFAWSDLHNLSALQLLKMDSN-ELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFT 167
           LIS  + + + NL  L+ ++  +N  L++I  +AF  L  L SL LN N L  L  GT  
Sbjct: 297 LISIDSLA-VDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIE 355

Query: 168 PLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRL--- 224
            L  L  + I+ NP  C C I W+      T +   E D++ C  P   +G  + ++   
Sbjct: 356 SLPNLKEISIHSNPIRCDCVIRWMN--MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFR 413

Query: 225 PPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPN 284
             +    P +     PS    E   G  ++ HC    +P P+++W    PSG  +   PN
Sbjct: 414 DMMEICLPLIAPESFPSNLNVE--AGSYVSFHCRATAEPQPEIYW--ITPSG--QKLLPN 467

Query: 285 VGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSV 340
             TD              +F   + G+L I      E G Y+C+ATN +G+   SV
Sbjct: 468 TLTD--------------KFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSV 509



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 55/176 (31%), Positives = 82/176 (46%), Gaps = 19/176 (10%)

Query: 48  FPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH 107
           FP N+T L LS N L  +     +++P L S++L  N++  +    L+ LS+L+ L ++H
Sbjct: 90  FPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINH 149

Query: 108 NLISDF---AWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEG 164
           NL+S     A+  LHNL  L L   +SN L  I    F +L  L  L +  N +  + + 
Sbjct: 150 NLLSTISPGAFIGLHNLLRLHL---NSNRLQMINSKWFDALPNLEILMIGENPIIRIKDM 206

Query: 165 TFTPLTALSHL-----QINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHV 215
            F PL  L  L      + E P +   G+  L+        SI   DN     PHV
Sbjct: 207 NFKPLINLRSLVIAGINLTEIPDNALVGLENLE--------SISFYDNRLIKVPHV 254


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score = 99.0 bits (245), Expect = 7e-21
 Identities = 99/357 (27%), Positives = 138/357 (38%), Gaps = 47/357 (13%)

Query: 11  LLLGL-AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRL----PG- 64
           LLL L A  CP  C C   Y   + +C    L  VP G P    TL L  N +    PG 
Sbjct: 14  LLLPLRAAGCPAACRC---YSATV-ECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGA 69

Query: 65  -------------------LPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDL 105
                              L  GAFR  P L  L L  N +R + +GA   L+ L+ L L
Sbjct: 70  LAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYL 129

Query: 106 SHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGT 165
           + N ++        +L  LQ L +  N +  +   A   L +L  L L+ N+L T++   
Sbjct: 130 AGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREA 189

Query: 166 FTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSI--PEQDNIACTSPHVLKGTPLSR 223
             PL +L  L++ ENP+ C C + WL  W       +       I C  P  L    L  
Sbjct: 190 LQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLD 249

Query: 224 L--PPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEIT 281
           +    L C  PSV +  QP +  A L  G  L + C   G P P + W         ++ 
Sbjct: 250 VSHSSLICIPPSVHV--QPLELTANL--GEDLRVACQASGYPQPLVTWR--------KVP 297

Query: 282 SPNVGTD--GRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSA 336
            P  G       L G  +           +G L + +      G Y C A+N  G+A
Sbjct: 298 QPREGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAA 354


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 59/158 (37%), Positives = 83/158 (52%), Gaps = 6/158 (3%)

Query: 19  CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78
           C  PC C    G +  DC+ + L +VP G  A    L +S N +  LPE AF+  P L+ 
Sbjct: 29  CAAPCSCD---GDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEE 85

Query: 79  LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138
           L LA N++  +   AL+ L  LK L L +N +       +  LSALQ L++D+N +T +P
Sbjct: 86  LQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVP 145

Query: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQ 176
            D+F  L  LR L L+ N   +L E    PL+ L  LQ
Sbjct: 146 EDSFEGLVQLRHLWLDDN---SLTEVPVHPLSNLPTLQ 180



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 42/130 (32%), Positives = 69/130 (53%), Gaps = 7/130 (5%)

Query: 54  TLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLIS-- 111
           +L L AN +  +PE +F  +  L+ LWL  N +  V    L++L  L++L L+ N IS  
Sbjct: 133 SLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSI 192

Query: 112 -DFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLT 170
            DFA++   NLS+L +L + +N++  + +  F  L  L +L LN+N L    +     L 
Sbjct: 193 PDFAFT---NLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ-AIKALP 248

Query: 171 ALSHLQINEN 180
           +L  L  + N
Sbjct: 249 SLKELGFHSN 258



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 48/191 (25%), Positives = 79/191 (41%), Gaps = 32/191 (16%)

Query: 15  LAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPA--NVTTLSLSANRLPGLPEGAFRE 72
           L+Q C +  D       +  D  Y +L   P    A  ++  L   +N +  +P+GAF  
Sbjct: 216 LSQHCFDGLD-----NLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDG 270

Query: 73  VPLLQSLWLAHNEIRTVAAGALASLS-----------------------HLKSLDLSHNL 109
            PLL+++ L  N +  V   A  +LS                       HL+SL L+   
Sbjct: 271 NPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTK 330

Query: 110 ISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPL 169
           IS    +       L+ L +  N +  +P  +F    AL  + L  N+++ + EGTF  L
Sbjct: 331 ISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGL 388

Query: 170 TALSHLQINEN 180
            +L  L ++ N
Sbjct: 389 ISLRILDLSRN 399



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 39/120 (32%), Positives = 52/120 (43%), Gaps = 3/120 (2%)

Query: 54  TLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDF 113
           TL LS N +  LP  +F     L+ + L  N+I  +  G    L  L+ LDLS NLI + 
Sbjct: 347 TLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEI 404

Query: 114 AWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALS 173
                  L  +  L +  NELT  P +    L  L+ L  N      LA   F  L +LS
Sbjct: 405 HSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK-LVGNFKLKEALAAKDFVNLRSLS 463



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 28/104 (26%), Positives = 56/104 (53%), Gaps = 1/104 (0%)

Query: 25  CGEKYGFQIADCAYRDLESVPPGFPAN-VTTLSLSANRLPGLPEGAFREVPLLQSLWLAH 83
           C E+   +  D +Y ++  +P     + +  +SL  N++  + EG F+ +  L+ L L+ 
Sbjct: 339 CQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSR 398

Query: 84  NEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLL 127
           N I  + + A A+L  + +LD+S N ++ F    L+ L+ L+L+
Sbjct: 399 NLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLV 442


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score = 96.3 bits (238), Expect = 5e-20
 Identities = 113/460 (24%), Positives = 162/460 (35%), Gaps = 132/460 (28%)

Query: 16  AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPAN------------------------ 51
           A +CP  C C  +    I  C  RDL  VP   P N                        
Sbjct: 54  ATSCPVACSCSNQASRVI--CTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRH 111

Query: 52  ------------------------VTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIR 87
                                   + TL L  NRL  +P  AF  +  L+ LWL +N I 
Sbjct: 112 LEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIE 171

Query: 88  TVAAGALASLSHLKSLDLSH----NLISDFAWSDLHNLSALQL----------------- 126
           ++ + A   +  L+ LDL        IS+ A+  L NL  L L                 
Sbjct: 172 SIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRL 231

Query: 127 --LKMDSNELTFI------------------------PRDAFRSLRALRSLQLNHNRLHT 160
             L++  N L  I                         R+AF  L++L  L L+HN L +
Sbjct: 232 EELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMS 291

Query: 161 LAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIA--CTSPHVLKG 218
           L    FTPL  L  + +N NP+ C C ++WL  W   T   +P        C +P  LKG
Sbjct: 292 LPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKET---VPSNTTCCARCHAPAGLKG 348

Query: 219 TPLSRLPP--LPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSG 276
             +  L      C AP +    +P  D   +  G    L C   G     ++W    P+G
Sbjct: 349 RYIGELDQSHFTCYAPVI---VEPPTD-LNVTEGMAAELKCRT-GTSMTSVNW--LTPNG 401

Query: 277 IVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELG-- 334
                   + T G         S + R     +G+L   +    + G Y+C+ TN  G  
Sbjct: 402 -------TLMTHG---------SYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNT 445

Query: 335 SAESSVDVALATP---GEGGEDTLGRRFHGKAVEGKGCYT 371
           +A ++++V+   P   G  G    G    G    G G YT
Sbjct: 446 TASATLNVSAVDPVAAGGTGSGGGGPGGSGGVGGGSGGYT 485


>gi|239752702 PREDICTED: leucine rich repeat containing 38, partial
           [Homo sapiens]
          Length = 254

 Score = 95.9 bits (237), Expect = 6e-20
 Identities = 58/180 (32%), Positives = 90/180 (50%), Gaps = 1/180 (0%)

Query: 35  DCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGAL 94
           DC  R L SVP  FP +V  L ++ NR+  +PE  F     L  L   +N +R++  G  
Sbjct: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60

Query: 95  ASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLN 154
           +  + L  LDLS+N ++        +   L  L + +N L  +  DAF +L +L+ L+LN
Sbjct: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120

Query: 155 HNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPE-QDNIACTSP 213
            N L +L+      L AL  L+++ NP+ C C    L +W    A  +P+  D I C+ P
Sbjct: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180


>gi|31542244 leucine rich repeat and fibronectin type III domain
           containing 5 [Homo sapiens]
          Length = 719

 Score = 95.5 bits (236), Expect = 8e-20
 Identities = 95/403 (23%), Positives = 153/403 (37%), Gaps = 100/403 (24%)

Query: 6   LLWWALLLGLA---QACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRL 62
           +L++  L+G+A   Q CP+ C C          CA + L  VPP        L L+ N +
Sbjct: 4   ILFYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFV 63

Query: 63  PGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDF------AWS 116
             +    F  +  L  L L+ N I  +   A A L +L++L L+ N ++          S
Sbjct: 64  TNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLS 123

Query: 117 DLHNL------------------SALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRL 158
           +LH+L                   AL+ L +  N L  IP DA   + +L +L L+HN +
Sbjct: 124 NLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMI 183

Query: 159 HTLAEGTFTPLTALSHLQINE-----------------------------------NPFD 183
             + +GTF+ L  ++ L +                                     NP  
Sbjct: 184 DNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLH 243

Query: 184 CTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLP--PLPCSAPSVQLSYQPS 241
           C C ++WL+  +        E D   C SP +L G     +P     C  P +      +
Sbjct: 244 CNCELLWLRRLS-------REDDLETCASPPLLTGRYFWSIPEEEFLCEPPLI------T 290

Query: 242 QDGAELR--PGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVAS 299
           +   E+R   G    L C   G P P +HW               +  +G+ +      S
Sbjct: 291 RHTHEMRVLEGQRATLRCKARGDPEPAIHW---------------ISPEGKLI------S 329

Query: 300 SQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDV 342
           +  R   + NG+L I      + G ++C+A+N  G A   VD+
Sbjct: 330 NATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDL 372


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,023,513
Number of Sequences: 37866
Number of extensions: 1000442
Number of successful extensions: 5802
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 289
Number of HSP's successfully gapped in prelim test: 146
Number of HSP's that attempted gapping in prelim test: 2932
Number of HSP's gapped (non-prelim): 1899
length of query: 428
length of database: 18,247,518
effective HSP length: 105
effective length of query: 323
effective length of database: 14,271,588
effective search space: 4609722924
effective search space used: 4609722924
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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