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Search of human proteins with 41582239
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41582239 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
(428 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41582239 immunoglobulin superfamily containing leucine-rich r... 874 0.0
gi|5031809 immunoglobulin superfamily containing leucine-rich re... 874 0.0
gi|194306623 immunoglobulin superfamily containing leucine-rich ... 383 e-106
gi|194306621 immunoglobulin superfamily containing leucine-rich ... 383 e-106
gi|39930401 immunoglobulin superfamily containing leucine-rich r... 383 e-106
gi|194306618 immunoglobulin superfamily containing leucine-rich ... 383 e-106
gi|4759146 slit homolog 2 [Homo sapiens] 120 3e-27
gi|109150416 peroxidasin [Homo sapiens] 119 4e-27
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho... 119 4e-27
gi|188528675 slit homolog 1 [Homo sapiens] 117 3e-26
gi|11321571 slit homolog 3 [Homo sapiens] 114 2e-25
gi|27363458 leucine rich repeat and fibronectin type III domain ... 113 3e-25
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho... 111 1e-24
gi|14149694 retina specific protein PAL [Homo sapiens] 110 2e-24
gi|13375646 leucine rich repeat and fibronectin type III domain ... 107 2e-23
gi|126517478 peroxidasin homolog-like [Homo sapiens] 107 2e-23
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 102 5e-22
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 102 7e-22
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 102 7e-22
gi|61966761 leucine rich repeat containing 26 [Homo sapiens] 101 1e-21
gi|139948432 adlican [Homo sapiens] 100 3e-21
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 99 6e-21
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 99 6e-21
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 99 6e-21
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 99 6e-21
gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 99 7e-21
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 98 2e-20
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 96 5e-20
gi|239752702 PREDICTED: leucine rich repeat containing 38, parti... 96 6e-20
gi|31542244 leucine rich repeat and fibronectin type III domain ... 96 8e-20
>gi|41582239 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 874 bits (2257), Expect = 0.0
Identities = 428/428 (100%), Positives = 428/428 (100%)
Query: 1 MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN 60
MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN
Sbjct: 1 MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN 60
Query: 61 RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN 120
RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN
Sbjct: 61 RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN 120
Query: 121 LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180
LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN
Sbjct: 121 LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180
Query: 181 PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP 240
PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP
Sbjct: 181 PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP 240
Query: 241 SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS 300
SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS
Sbjct: 241 SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS 300
Query: 301 QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH 360
QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH
Sbjct: 301 QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH 360
Query: 361 GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL 420
GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL
Sbjct: 361 GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL 420
Query: 421 LFFFLTSF 428
LFFFLTSF
Sbjct: 421 LFFFLTSF 428
>gi|5031809 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 874 bits (2257), Expect = 0.0
Identities = 428/428 (100%), Positives = 428/428 (100%)
Query: 1 MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN 60
MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN
Sbjct: 1 MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN 60
Query: 61 RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN 120
RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN
Sbjct: 61 RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN 120
Query: 121 LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180
LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN
Sbjct: 121 LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180
Query: 181 PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP 240
PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP
Sbjct: 181 PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP 240
Query: 241 SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS 300
SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS
Sbjct: 241 SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS 300
Query: 301 QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH 360
QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH
Sbjct: 301 QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH 360
Query: 361 GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL 420
GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL
Sbjct: 361 GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL 420
Query: 421 LFFFLTSF 428
LFFFLTSF
Sbjct: 421 LFFFLTSF 428
>gi|194306623 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 383 bits (983), Expect = e-106
Identities = 217/426 (50%), Positives = 260/426 (61%), Gaps = 50/426 (11%)
Query: 1 MQELHLLW--WALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLS 58
M L LW WALL G+A +CPEPC C +KY Q ADCAY++L VP G PANVTTLSLS
Sbjct: 1 MFPLRALWLVWALL-GVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLS 59
Query: 59 ANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDL 118
AN++ L GAF +V + SLWLAHNE+RTV GALA LS LK+LDLSHN IS F WSDL
Sbjct: 60 ANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDL 119
Query: 119 HNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQIN 178
NLSALQLLKM+ N L +PRDA +L LRSL++N+NRL TLA GTF L+ALSHLQ+
Sbjct: 120 RNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLY 179
Query: 179 ENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSY 238
NPF C CG+VWL+ WA +T VS+PE D+IAC SP L+G P+ RLP LPC+ PSV LS
Sbjct: 180 HNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSA 239
Query: 239 QPSQD--GAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSP-------NVGT-- 287
+P + G LR G LHC DG P P+L W +QIP G V + P VG
Sbjct: 240 EPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEE 299
Query: 288 -----DGRAL-----------PGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATN 331
DG L P P + PRF A ANGSLL+P E G Y+C A N
Sbjct: 300 GEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHN 359
Query: 332 ELGSAESSVDVALA-------TPGEGGE-----DTLGRRFHGKAVEGKGCYTVDNEVQPS 379
ELG+ +S+ VA+A PG GGE T R+ +G+G N V PS
Sbjct: 360 ELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERK---STAKGRG-----NSVLPS 411
Query: 380 GPEDNV 385
PE +
Sbjct: 412 KPEGKI 417
>gi|194306621 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 383 bits (983), Expect = e-106
Identities = 217/426 (50%), Positives = 260/426 (61%), Gaps = 50/426 (11%)
Query: 1 MQELHLLW--WALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLS 58
M L LW WALL G+A +CPEPC C +KY Q ADCAY++L VP G PANVTTLSLS
Sbjct: 1 MFPLRALWLVWALL-GVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLS 59
Query: 59 ANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDL 118
AN++ L GAF +V + SLWLAHNE+RTV GALA LS LK+LDLSHN IS F WSDL
Sbjct: 60 ANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDL 119
Query: 119 HNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQIN 178
NLSALQLLKM+ N L +PRDA +L LRSL++N+NRL TLA GTF L+ALSHLQ+
Sbjct: 120 RNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLY 179
Query: 179 ENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSY 238
NPF C CG+VWL+ WA +T VS+PE D+IAC SP L+G P+ RLP LPC+ PSV LS
Sbjct: 180 HNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSA 239
Query: 239 QPSQD--GAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSP-------NVGT-- 287
+P + G LR G LHC DG P P+L W +QIP G V + P VG
Sbjct: 240 EPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEE 299
Query: 288 -----DGRAL-----------PGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATN 331
DG L P P + PRF A ANGSLL+P E G Y+C A N
Sbjct: 300 GEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHN 359
Query: 332 ELGSAESSVDVALA-------TPGEGGE-----DTLGRRFHGKAVEGKGCYTVDNEVQPS 379
ELG+ +S+ VA+A PG GGE T R+ +G+G N V PS
Sbjct: 360 ELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERK---STAKGRG-----NSVLPS 411
Query: 380 GPEDNV 385
PE +
Sbjct: 412 KPEGKI 417
>gi|39930401 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 383 bits (983), Expect = e-106
Identities = 217/426 (50%), Positives = 260/426 (61%), Gaps = 50/426 (11%)
Query: 1 MQELHLLW--WALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLS 58
M L LW WALL G+A +CPEPC C +KY Q ADCAY++L VP G PANVTTLSLS
Sbjct: 1 MFPLRALWLVWALL-GVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLS 59
Query: 59 ANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDL 118
AN++ L GAF +V + SLWLAHNE+RTV GALA LS LK+LDLSHN IS F WSDL
Sbjct: 60 ANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDL 119
Query: 119 HNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQIN 178
NLSALQLLKM+ N L +PRDA +L LRSL++N+NRL TLA GTF L+ALSHLQ+
Sbjct: 120 RNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLY 179
Query: 179 ENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSY 238
NPF C CG+VWL+ WA +T VS+PE D+IAC SP L+G P+ RLP LPC+ PSV LS
Sbjct: 180 HNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSA 239
Query: 239 QPSQD--GAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSP-------NVGT-- 287
+P + G LR G LHC DG P P+L W +QIP G V + P VG
Sbjct: 240 EPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEE 299
Query: 288 -----DGRAL-----------PGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATN 331
DG L P P + PRF A ANGSLL+P E G Y+C A N
Sbjct: 300 GEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHN 359
Query: 332 ELGSAESSVDVALA-------TPGEGGE-----DTLGRRFHGKAVEGKGCYTVDNEVQPS 379
ELG+ +S+ VA+A PG GGE T R+ +G+G N V PS
Sbjct: 360 ELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERK---STAKGRG-----NSVLPS 411
Query: 380 GPEDNV 385
PE +
Sbjct: 412 KPEGKI 417
>gi|194306618 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 383 bits (983), Expect = e-106
Identities = 217/426 (50%), Positives = 260/426 (61%), Gaps = 50/426 (11%)
Query: 1 MQELHLLW--WALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLS 58
M L LW WALL G+A +CPEPC C +KY Q ADCAY++L VP G PANVTTLSLS
Sbjct: 1 MFPLRALWLVWALL-GVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLS 59
Query: 59 ANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDL 118
AN++ L GAF +V + SLWLAHNE+RTV GALA LS LK+LDLSHN IS F WSDL
Sbjct: 60 ANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDL 119
Query: 119 HNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQIN 178
NLSALQLLKM+ N L +PRDA +L LRSL++N+NRL TLA GTF L+ALSHLQ+
Sbjct: 120 RNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLY 179
Query: 179 ENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSY 238
NPF C CG+VWL+ WA +T VS+PE D+IAC SP L+G P+ RLP LPC+ PSV LS
Sbjct: 180 HNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSA 239
Query: 239 QPSQD--GAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSP-------NVGT-- 287
+P + G LR G LHC DG P P+L W +QIP G V + P VG
Sbjct: 240 EPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEE 299
Query: 288 -----DGRAL-----------PGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATN 331
DG L P P + PRF A ANGSLL+P E G Y+C A N
Sbjct: 300 GEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHN 359
Query: 332 ELGSAESSVDVALA-------TPGEGGE-----DTLGRRFHGKAVEGKGCYTVDNEVQPS 379
ELG+ +S+ VA+A PG GGE T R+ +G+G N V PS
Sbjct: 360 ELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERK---STAKGRG-----NSVLPS 411
Query: 380 GPEDNV 385
PE +
Sbjct: 412 KPEGKI 417
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 120 bits (300), Expect = 3e-27
Identities = 68/206 (33%), Positives = 104/206 (50%), Gaps = 7/206 (3%)
Query: 19 CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78
CP C C I DC + L +P P +T + L N + +P GAF L+
Sbjct: 273 CPAACTCSNN----IVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRR 328
Query: 79 LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138
+ L++N+I +A A L L SL L N I++ S L +LQLL +++N++ +
Sbjct: 329 IDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLR 388
Query: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTT 198
DAF+ L L L L N+L T+A+GTF+PL A+ + + +NPF C C + WL + T
Sbjct: 389 VDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTN 448
Query: 199 AVSIPEQDNIACTSPHVLKGTPLSRL 224
+ E CTSP L + ++
Sbjct: 449 PI---ETSGARCTSPRRLANKRIGQI 471
Score = 101 bits (252), Expect = 1e-21
Identities = 61/205 (29%), Positives = 97/205 (47%), Gaps = 8/205 (3%)
Query: 18 ACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPE-GAFREVPLL 76
ACPE C C DC+ + L +P P L L+ N L G F+++P L
Sbjct: 505 ACPEKCRCEGT----TVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQL 560
Query: 77 QSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTF 136
+ + ++N+I + GA S + + L+ N + + L +L+ L + SN +T
Sbjct: 561 RKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITC 620
Query: 137 IPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWAL 196
+ D+F L ++R L L N++ T+A G F L +LS L + NPF+C C + WL W
Sbjct: 621 VGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLR 680
Query: 197 TTAVSIPEQDNIACTSPHVLKGTPL 221
+ N C P+ LK P+
Sbjct: 681 KKRI---VTGNPRCQKPYFLKEIPI 702
Score = 90.9 bits (224), Expect = 2e-18
Identities = 55/176 (31%), Positives = 80/176 (45%), Gaps = 29/176 (16%)
Query: 19 CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78
CP C C + + C+ + L+ +P G P +VT L L N+ +P+
Sbjct: 727 CPTECTCLDT----VVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK----------- 771
Query: 79 LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138
L++ HL +DLS+N IS + N++ L L + N L IP
Sbjct: 772 --------------ELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIP 817
Query: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTW 194
F L++LR L L+ N + + EG F L+ALSHL I NP C C + WL W
Sbjct: 818 PRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDW 873
Score = 85.1 bits (209), Expect = 1e-16
Identities = 57/202 (28%), Positives = 83/202 (41%), Gaps = 28/202 (13%)
Query: 17 QACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLL 76
QACP C C DC L SVP P N L L+ N + + + F + L
Sbjct: 26 QACPAQCSCSGS----TVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHL 81
Query: 77 QSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTF 136
+ L L N+I T+ GA L L+ L L+ N + F + L L + N++
Sbjct: 82 RVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQA 141
Query: 137 IPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFD------------- 183
IPR AFR +++LQL++N++ + +G F L L L +N N
Sbjct: 142 IPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKL 201
Query: 184 -----------CTCGIVWLKTW 194
C C + WL W
Sbjct: 202 RTFRLHSNNLYCDCHLAWLSDW 223
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 119 bits (299), Expect = 4e-27
Identities = 88/334 (26%), Positives = 149/334 (44%), Gaps = 31/334 (9%)
Query: 9 WALLLGLAQ----ACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPG 64
W L +AQ CP C C C + LE+VP P + L L NR+
Sbjct: 22 WGTLAVVAQKPGAGCPSRCLCFRT----TVRCMHLLLEAVPAVAP-QTSILDLRFNRIRE 76
Query: 65 LPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSAL 124
+ GAFR + L +L L +N+I+ + +GA L +LK L L N I L++L
Sbjct: 77 IQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASL 136
Query: 125 QLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDC 184
+ L + N++ + D+F+ L L L L++NR+ L GTF L ++ L+++ N C
Sbjct: 137 EQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHC 196
Query: 185 TCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQDG 244
C I+WL T A S Q C P ++G ++ + P + +++ +P
Sbjct: 197 DCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQD-- 254
Query: 245 AELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRF 304
A++ G + C +G P P++ W + ++ TD R
Sbjct: 255 ADVTSGNTVYFTCRAEGNPKPEIIW-------LRNNNELSMKTDS-------------RL 294
Query: 305 QAFANGSLLIPDFGKLEEGTYSCLATNELGSAES 338
+G+L+I + + ++G Y C+A N G ++
Sbjct: 295 NLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKT 328
Score = 47.8 bits (112), Expect = 2e-05
Identities = 82/386 (21%), Positives = 141/386 (36%), Gaps = 106/386 (27%)
Query: 33 IADCAYRDLESVPPGF---PANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTV 89
I D + + + PG N+ TL L+ N++ +P GAF ++ L+ L+L NEI+++
Sbjct: 66 ILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSI 125
Query: 90 ---AAGALASLS------------------HLKSLD---LSHNLISDFAWSDLHNLSALQ 125
A LASL HL L+ L +N I+ ++L +++
Sbjct: 126 DRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMK 185
Query: 126 LLKMDSNEL----------------------------TFIPRDAFRSLRALRSLQLNHNR 157
L++DSN L + R RS+ + +LN R
Sbjct: 186 RLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCER 245
Query: 158 LHTLAEGTFTPLTALSHLQINENPFDCTCG------IVWLKTWALTTAVSIPEQDNIACT 211
+E +T+ + + F C I+WL+ ++ + N+
Sbjct: 246 PRITSEPQDADVTSGNTVY-----FTCRAEGNPKPEIIWLRN-NNELSMKTDSRLNLLDD 299
Query: 212 SPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQD-----GAELRPGFVL------------- 253
+++ T + C A +V + + G+ RP FV+
Sbjct: 300 GTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESV 359
Query: 254 ALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLL 313
L C G P P++ W T G P PV PR +G L
Sbjct: 360 TLECSATGHPPPRISW-----------------TRGDRTP-LPV---DPRVNITPSGGLY 398
Query: 314 IPDFGKLEEGTYSCLATNELGSAESS 339
I + + + G Y+C ATN + S ++
Sbjct: 399 IQNVVQGDSGEYACSATNNIDSVHAT 424
Score = 37.4 bits (85), Expect = 0.026
Identities = 35/157 (22%), Positives = 58/157 (36%), Gaps = 39/157 (24%)
Query: 198 TAVSIPEQDNIACTSPHVLKG-------TPLSRLPPLPCSAPSVQLSYQPSQDGAELRPG 250
+ V++ +Q C + +++ T R+ P+ S PS + G
Sbjct: 490 SGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPS----------DTTVEVG 539
Query: 251 FVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANG 310
+ L C G+P P + W+ G V S +F G
Sbjct: 540 ANVQLPCSSQGEPEPAITWNKD---------------------GVQVTESG-KFHISPEG 577
Query: 311 SLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATP 347
L I D G + G Y C+A N +GSA S+ +++ P
Sbjct: 578 FLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVP 614
>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
sapiens]
Length = 345
Score = 119 bits (299), Expect = 4e-27
Identities = 81/269 (30%), Positives = 121/269 (44%), Gaps = 16/269 (5%)
Query: 11 LLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAF 70
+LL + +CP+ C C F DC+ + L +P P TL L N++ LP AF
Sbjct: 13 VLLQVVCSCPDKCYCQSSTNF--VDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAF 70
Query: 71 REVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMD 130
R VP L +L L++N + +A GA L HL+ L+L+ N + H+L L+ L +
Sbjct: 71 RSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLS 130
Query: 131 SNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVW 190
SN ++ +P + L L + N+L L + ++ L + +N + C C ++
Sbjct: 131 SNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLG 190
Query: 191 LKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLP-----PLPCSAP---SVQLSYQPSQ 242
LK W D I C SP KG L R+P P P AP S Q + S
Sbjct: 191 LKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSA 250
Query: 243 DGAELRP------GFVLALHCDVDGQPAP 265
G LRP G L C++ +P P
Sbjct: 251 HGVVLRPPENHNAGERELLECELKPKPRP 279
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 117 bits (292), Expect = 3e-26
Identities = 68/207 (32%), Positives = 103/207 (49%), Gaps = 7/207 (3%)
Query: 18 ACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQ 77
+CP C C I DC + L ++P P +T + L N + +P GAF L+
Sbjct: 281 SCPAMCTCSNG----IVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLR 336
Query: 78 SLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFI 137
+ L++N+I +A A L L SL L N I+D L LQLL +++N++ I
Sbjct: 337 RIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCI 396
Query: 138 PRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALT 197
DAF+ L+ L L L N++ +LA+GTFT L A+ L + +NPF C C + WL + T
Sbjct: 397 RPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRT 456
Query: 198 TAVSIPEQDNIACTSPHVLKGTPLSRL 224
+ E C SP L + ++
Sbjct: 457 NPI---ETSGARCASPRRLANKRIGQI 480
Score = 107 bits (267), Expect = 2e-23
Identities = 70/216 (32%), Positives = 98/216 (45%), Gaps = 34/216 (15%)
Query: 19 CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78
CP+ C C + + C+ + L ++P G P NVT L L N+
Sbjct: 734 CPQECACLDT----VVRCSNKHLRALPKGIPKNVTELYLDGNQF---------------- 773
Query: 79 LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138
T+ G L++ +L+ +DLS+N IS + S N+S L L + N L IP
Sbjct: 774 ---------TLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIP 824
Query: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTT 198
AF+ LR+LR L L+ N + TL EG F +T+LSHL I NP C C + WL +W T
Sbjct: 825 PLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKT- 883
Query: 199 AVSIPEQDNIACTSPHVLKGTPLSRLP--PLPCSAP 232
E C P ++G L P C P
Sbjct: 884 --GYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGP 917
Score = 94.4 bits (233), Expect = 2e-19
Identities = 56/204 (27%), Positives = 95/204 (46%), Gaps = 8/204 (3%)
Query: 19 CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPE-GAFREVPLLQ 77
CP C C + +C+ L +P P + L L+ N + L G F+++ L+
Sbjct: 513 CPHKCRCEAN----VVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLK 568
Query: 78 SLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFI 137
+ L++N++ + GA + + L L+ N + L L+ L + +N ++ I
Sbjct: 569 KINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCI 628
Query: 138 PRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALT 197
D+F LR +R L L N++ T++ G F L +LS L + NPF+C C + WL W
Sbjct: 629 HNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRK 688
Query: 198 TAVSIPEQDNIACTSPHVLKGTPL 221
+ N C +P L+ PL
Sbjct: 689 RKI---VTGNPRCQNPDFLRQIPL 709
Score = 90.5 bits (223), Expect = 3e-18
Identities = 64/217 (29%), Positives = 88/217 (40%), Gaps = 29/217 (13%)
Query: 3 ELHLLWWALLLGL-AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANR 61
EL LL WA L A ACP C C DC L+++P P N L L+ N
Sbjct: 17 ELWLLLWAAAWRLGASACPALCTCTGT----TVDCHGTGLQAIPKNIPRNTERLELNGNN 72
Query: 62 LPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNL 121
+ + + F + L+ L L N+I V GA + L+ L L+ N + N
Sbjct: 73 ITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNN 132
Query: 122 SALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENP 181
AL L + N + IPR AFR L++LQL+ N++ + EG F L L L +N N
Sbjct: 133 QALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNN 192
Query: 182 FD------------------------CTCGIVWLKTW 194
C C + WL W
Sbjct: 193 ITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQW 229
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 114 bits (284), Expect = 2e-25
Identities = 62/207 (29%), Positives = 103/207 (49%), Gaps = 7/207 (3%)
Query: 18 ACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQ 77
+CP PC C I DC + L +P P + + L N + +P GAF + L+
Sbjct: 279 SCPSPCTCSNN----IVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLK 334
Query: 78 SLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFI 137
+ ++ N+I +A A L L SL L N I++ A L +LQLL +++N++ +
Sbjct: 335 RIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCL 394
Query: 138 PRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALT 197
+ F+ L+ L L L N+L T+++G F PL ++ L + +NPF C C + WL +
Sbjct: 395 RVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQD 454
Query: 198 TAVSIPEQDNIACTSPHVLKGTPLSRL 224
+ E C+SP L +S++
Sbjct: 455 NPI---ETSGARCSSPRRLANKRISQI 478
Score = 107 bits (266), Expect = 3e-23
Identities = 65/204 (31%), Positives = 99/204 (48%), Gaps = 8/204 (3%)
Query: 19 CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPE-GAFREVPLLQ 77
CPE C C I DC+ + L +P P VT L L+ N + L G F+++P L+
Sbjct: 505 CPEKCRCEGT----IVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLR 560
Query: 78 SLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFI 137
+ L++N+I+ V GA + ++ L L+ N + LS L+ L + SN + +
Sbjct: 561 KINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCV 620
Query: 138 PRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALT 197
D F L ++R L L NR+ T+ G FT L +LS + + NPF+C C + WL W
Sbjct: 621 SNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRK 680
Query: 198 TAVSIPEQDNIACTSPHVLKGTPL 221
+ N C P LK P+
Sbjct: 681 RRI---VSGNPRCQKPFFLKEIPI 701
Score = 105 bits (261), Expect = 1e-22
Identities = 70/220 (31%), Positives = 95/220 (43%), Gaps = 34/220 (15%)
Query: 15 LAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVP 74
L+ CPE C C E + C+ + L ++P G P +VT L L N L +P
Sbjct: 721 LSPRCPEQCTCMET----VVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPR------- 769
Query: 75 LLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNEL 134
L++L HL +DLS+N IS N+S L L + N L
Sbjct: 770 ------------------ELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRL 811
Query: 135 TFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTW 194
IP AF LR+LR L L+ N + ++ EG+F LT+LSHL + NP C C + WL W
Sbjct: 812 RCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEW 871
Query: 195 ALTTAVSIPEQDNIACTSPHVLKGTPLSRLPP--LPCSAP 232
E C+SP + L P C P
Sbjct: 872 ---VKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGP 908
Score = 82.0 bits (201), Expect = 9e-16
Identities = 54/203 (26%), Positives = 84/203 (41%), Gaps = 28/203 (13%)
Query: 16 AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPL 75
A ACP C C DC L +VP G P N L L N + + + F +
Sbjct: 31 AVACPTKCTCSAAS----VDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKN 86
Query: 76 LQSLWLAHNEIRTVAAGALASLSHLKSL------------------------DLSHNLIS 111
L+ L L N++ + GA L L+ L DLS N I
Sbjct: 87 LRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQ 146
Query: 112 DFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTA 171
++ ++ L++D+N ++ I AFR+LR L L LN+N + + +F +
Sbjct: 147 GIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPK 206
Query: 172 LSHLQINENPFDCTCGIVWLKTW 194
+ L+++ N C C + WL W
Sbjct: 207 IRTLRLHSNHLYCDCHLAWLSDW 229
Score = 39.3 bits (90), Expect = 0.007
Identities = 22/71 (30%), Positives = 35/71 (49%)
Query: 127 LKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTC 186
L +D N +T I + F L+ LR L L N++ + G F L L L++N+N
Sbjct: 66 LDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLP 125
Query: 187 GIVWLKTWALT 197
+++ T LT
Sbjct: 126 ELLFQSTPKLT 136
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 113 bits (283), Expect = 3e-25
Identities = 104/337 (30%), Positives = 140/337 (41%), Gaps = 59/337 (17%)
Query: 37 AYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALAS 96
A+ DLES+ +L L NRL L G+ R LQ L L+ N++ +A GA
Sbjct: 91 AFGDLESL--------RSLHLDGNRLVELGTGSLRGPVNLQHLILSGNQLGRIAPGAFDD 142
Query: 97 -LSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNH 155
L L+ LDLS+N + W+ + + AL L +D N + +P AF L L L L
Sbjct: 143 FLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLSRLDLTS 202
Query: 156 NRLHTL-----------AEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPE 204
NRL TL AE + PL L + NP C C ++WL+ A
Sbjct: 203 NRLATLAPDPLFSRGRDAEASPAPLV----LSFSGNPLHCNCELLWLRRLA-------RP 251
Query: 205 QDNIACTSPHVLKGTPLSRLP--PLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQ 262
D C SP L G +P C P + Q + G L C G
Sbjct: 252 DDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQ----RLWVLEGQRATLRCRALGD 307
Query: 263 PAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEE 322
PAP +HW VG D R + + R +AF NG+L I G +
Sbjct: 308 PAPTMHW---------------VGPDDR------LVGNSSRARAFPNGTLEIGVTGAGDA 346
Query: 323 GTYSCLATNELGSAESSVDV-ALATPGEGGEDTLGRR 358
G Y+C+ATN G A + V++ LA P G G R
Sbjct: 347 GGYTCIATNPAGEATARVELRVLALPHGGNSSAEGGR 383
>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
sapiens]
Length = 370
Score = 111 bits (278), Expect = 1e-24
Identities = 78/232 (33%), Positives = 110/232 (47%), Gaps = 4/232 (1%)
Query: 19 CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78
CP C C + ++ DC+ L +VPP PA TL L N+L LP AF + LQ
Sbjct: 39 CPFSCKCDSR-SLEV-DCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQR 96
Query: 79 LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138
L L++N + + L++L L L +N I L + L+ L + N L +P
Sbjct: 97 LDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLP 156
Query: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTT 198
F L ALRSL L NRL L TF PL L LQ+ +NP++C C + K W
Sbjct: 157 PGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWF 216
Query: 199 AVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPG 250
+ D +ACT P L+G + R+ P+ QL + S G ++ PG
Sbjct: 217 SYRGGRLDQLACTLPKELRGKDM-RMVPMEMFNYCSQLEDENSSAGLDI-PG 266
>gi|14149694 retina specific protein PAL [Homo sapiens]
Length = 623
Score = 110 bits (276), Expect = 2e-24
Identities = 98/372 (26%), Positives = 146/372 (39%), Gaps = 56/372 (15%)
Query: 4 LHLLWWALLLGLAQA---CPEPCDC-----GEKYGFQIADCAYRDLESVPPGFPANVTTL 55
L +LW L QA CP C C G+ + C D+ P P + + L
Sbjct: 5 LGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRL 64
Query: 56 SLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAW 115
L + +P AFR + L+ LWL +N + + A L L L+ L L N ++ F W
Sbjct: 65 RLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPW 124
Query: 116 SDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAE-----------G 164
+ L + L+LL + +N L+ +P +A R L L L L+ N+L L + G
Sbjct: 125 AALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETG 184
Query: 165 TFTPLTALSH-----LQINENPFDCTCGIV----WLKTWALTTAVSIPEQDNIACTSPHV 215
F P H L + +NP+ C C + L WA A + + C SP
Sbjct: 185 IFPP----GHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFI---ETELRCASPRS 237
Query: 216 LKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPS 275
L G S+L C P + P G L C G P P++ W
Sbjct: 238 LAGVAFSQLELRKCQGPEL----HPGVASIRSLLGGTALLRCGATGVPGPEMSWR----- 288
Query: 276 GIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGS 335
+GR L GT + + L +P L+ G Y C A N LG+
Sbjct: 289 ----------RANGRPLNGT--VHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGA 336
Query: 336 AESSVDVALATP 347
+E+ + + + P
Sbjct: 337 SETVISLIVTEP 348
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 107 bits (268), Expect = 2e-23
Identities = 93/308 (30%), Positives = 129/308 (41%), Gaps = 48/308 (15%)
Query: 55 LSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSH-LKSLDLSHNLISDF 113
L L NRL L EG R + L+ L L++N++ +AAGAL + L+ LDLS+N +
Sbjct: 112 LHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQL 171
Query: 114 AWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHT------------L 161
W L L + L +D N L +P AF L L L + NRL T L
Sbjct: 172 PWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLL 231
Query: 162 AEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPL 221
A +P +AL L NP C C +VWL+ A E D AC SP L G
Sbjct: 232 ARPRGSPASALV-LAFGGNPLHCNCELVWLRRLA-------REDDLEACASPPALGGRYF 283
Query: 222 SRL--PPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVE 279
+ C P V P + G AL C G P P++ W
Sbjct: 284 WAVGEEEFVCEPPVVTHRSPP----LAVPAGRPAALRCRAVGDPEPRVRW---------- 329
Query: 280 ITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESS 339
V GR L + R +AF NG+L + + G ++C+A N G A ++
Sbjct: 330 -----VSPQGRLL------GNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAA 378
Query: 340 VDVALATP 347
V++ + P
Sbjct: 379 VELTVGPP 386
Score = 52.4 bits (124), Expect = 8e-07
Identities = 30/78 (38%), Positives = 42/78 (53%)
Query: 103 LDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLA 162
L L+ N I+ DL N++ L L + N + + AF LRALR+L L+ NRL +L
Sbjct: 64 LRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLG 123
Query: 163 EGTFTPLTALSHLQINEN 180
EG L L HL ++ N
Sbjct: 124 EGQLRGLVNLRHLILSNN 141
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 107 bits (268), Expect = 2e-23
Identities = 86/342 (25%), Positives = 142/342 (41%), Gaps = 33/342 (9%)
Query: 3 ELHLLWWALLLGLAQ------ACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLS 56
E L W L LA CP C C + C + L+ +P P T L
Sbjct: 2 EPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKS----TVRCMHLMLDHIPQ-VPQQTTVLD 56
Query: 57 LSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWS 116
L NR+ +P AF+++ L +L L +N IR ++ A L +L L L N I
Sbjct: 57 LRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQ 116
Query: 117 DLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQ 176
L +L+ L + N+L + + F L L L L++N+L + G+F+ L +L L+
Sbjct: 117 TFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLR 176
Query: 177 INENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQL 236
++ N C C ++WL A Q C P L G ++ + + S ++
Sbjct: 177 LDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRI 236
Query: 237 SYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTP 296
+++P E+ G + C +G P P++ W N D
Sbjct: 237 TFEPQD--VEVPSGNTVYFTCRAEGNPKPEIIW-----------IHNNHSLD-------- 275
Query: 297 VASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAES 338
R F +G+L+I + + ++G Y C+A N G A++
Sbjct: 276 -LEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKT 316
Score = 31.2 bits (69), Expect = 1.9
Identities = 27/116 (23%), Positives = 45/116 (38%), Gaps = 30/116 (25%)
Query: 233 SVQLSYQPSQ--------DGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPN 284
SVQL+ +P + G + + C G+P P + W+ + V+IT
Sbjct: 500 SVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEG----VQITESG 555
Query: 285 VGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSV 340
+F G+L I D G ++G Y C+A N G A +++
Sbjct: 556 ------------------KFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNM 593
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 102 bits (255), Expect = 5e-22
Identities = 96/326 (29%), Positives = 139/326 (42%), Gaps = 61/326 (18%)
Query: 61 RLPGLPEGAFREVPLLQ-------------SLWLAHNEIRTVAAGALASLSHLKSLDLSH 107
RLPGL PLL+ SL + H I V A AL +HL L+LSH
Sbjct: 220 RLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSH 279
Query: 108 NLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFT 167
N IS +L L+ L + L + AF LR +R L L++N L TL E TF
Sbjct: 280 NPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFH 339
Query: 168 PLTALSHLQINENPFDCTCGIVWL--KTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLP 225
+ L L+++ NP C C ++W+ + L +P AC +P ++G L LP
Sbjct: 340 SVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLP-----ACATPAEVRGDALRNLP 394
Query: 226 P------LPCSAPSV---QLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSG 276
C P + +L + G ++R C +G+PAP + W +
Sbjct: 395 DSVLFEYFVCRKPKIRERRLQRVTATAGEDVR------FLCRAEGEPAPTVAW---VTPQ 445
Query: 277 IVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGS- 335
+T+ + G R LPG G+L I D + GTY+C+A+N G+
Sbjct: 446 HRPVTATSAGR-ARVLPG---------------GTLEIQDARPQDSGTYTCVASNAGGND 489
Query: 336 ---AESSV---DVALATPGEGGEDTL 355
A +V A TPGE +TL
Sbjct: 490 TYFATLTVRPEPAANRTPGEAHNETL 515
Score = 78.6 bits (192), Expect = 1e-14
Identities = 60/189 (31%), Positives = 86/189 (45%), Gaps = 32/189 (16%)
Query: 16 AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANR-----------LPG 64
A CP C+C + + C R L +VP G PA L LS NR LP
Sbjct: 22 AGGCPARCECTVQT--RAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPA 79
Query: 65 LPE-------------GAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHN--- 108
L E GAF +P L+ L L N+++ + G L +L LDLS N
Sbjct: 80 LEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLV 139
Query: 109 LISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTP 168
++ D+ + DLH +L+ L++ N+L F+ R AF L AL L L L L+ +
Sbjct: 140 ILLDYTFQDLH---SLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGH 196
Query: 169 LTALSHLQI 177
L +L L++
Sbjct: 197 LRSLGALRL 205
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 102 bits (254), Expect = 7e-22
Identities = 94/332 (28%), Positives = 149/332 (44%), Gaps = 51/332 (15%)
Query: 32 QIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAA 91
+I+D A L+S+ +LS N+L +P A +VP L+ L L N ++ V
Sbjct: 227 EISDYALEGLQSLE--------SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGP 278
Query: 92 GALASLSHLKSLDLSHN----LISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRA 147
G A++ HLK L L++ I FA +L L+ L + ++ L+FI AF L
Sbjct: 279 GDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDIT--NNPRLSFIHPRAFHHLPQ 336
Query: 148 LRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDN 207
+ +L LN+N L L + T L L + ++ NP C C I W A T V E +
Sbjct: 337 METLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWAN--ATGTRVRFIEPQS 394
Query: 208 IACTSPHVLKGTPLSRLP-------PLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVD 260
C P L+ P+ +P LP +P S+ PS ++ G + LHC
Sbjct: 395 TLCAEPPDLQRLPVREVPFREMTDHCLPLISPR---SFPPS---LQVASGESMVLHCRAL 448
Query: 261 GQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKL 320
+P P+++W P+G+ +T + G R++ + G+L +
Sbjct: 449 AEPEPEIYW--VTPAGL-RLTPAHAGR---------------RYRVYPEGTLELRRVTAE 490
Query: 321 EEGTYSCLATNELGSAESSVDV----ALATPG 348
E G Y+C+A N +G+ +V V AL PG
Sbjct: 491 EAGLYTCVAQNLVGADTKTVSVVVGRALLQPG 522
Score = 71.2 bits (173), Expect = 2e-12
Identities = 55/171 (32%), Positives = 73/171 (42%), Gaps = 33/171 (19%)
Query: 19 CPEPCDCGEKYGFQ---------IADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGA 69
CP C C + + DC L +VPP PA TL
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTL-------------- 74
Query: 70 FREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKM 129
LLQS N I V L L++L LDLS N SD D H L L L +
Sbjct: 75 -----LLQS-----NSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHL 124
Query: 130 DSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180
+ N+LT + +F L +L+ L LNHN+L+ +A F+ L+ L L +N N
Sbjct: 125 EENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSN 175
Score = 57.4 bits (137), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%)
Query: 47 GFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLS 106
G+ AN+T L LS N + F +P L SL L N++ + + A L+ L+ L L+
Sbjct: 90 GYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLN 149
Query: 107 HNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTF 166
HN + A LS L L ++SN L I F L L L + N++ + + F
Sbjct: 150 HNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNF 209
Query: 167 TPLTALSHL 175
PL L L
Sbjct: 210 RPLANLRSL 218
Score = 55.8 bits (133), Expect = 7e-08
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 4/129 (3%)
Query: 54 TLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLIS-- 111
+L L N+L L + +F + LQ L+L HN++ +A A + LS+L L L+ NL+
Sbjct: 121 SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI 180
Query: 112 DFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTA 171
D W ++ L L++L + N++ I FR L LRSL L L +++ L +
Sbjct: 181 DSRWFEM--LPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQS 238
Query: 172 LSHLQINEN 180
L L +N
Sbjct: 239 LESLSFYDN 247
Score = 55.1 bits (131), Expect = 1e-07
Identities = 41/132 (31%), Positives = 66/132 (50%), Gaps = 6/132 (4%)
Query: 50 ANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH-N 108
+N+ L L++N L + F +P L+ L + N++ + L++L+SL L+ N
Sbjct: 165 SNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMN 224
Query: 109 L--ISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTF 166
L ISD+A L L +L+ L N+L +PR A + L+ L LN N L + G F
Sbjct: 225 LREISDYA---LEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDF 281
Query: 167 TPLTALSHLQIN 178
+ L L +N
Sbjct: 282 ANMLHLKELGLN 293
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 102 bits (254), Expect = 7e-22
Identities = 94/332 (28%), Positives = 149/332 (44%), Gaps = 51/332 (15%)
Query: 32 QIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAA 91
+I+D A L+S+ +LS N+L +P A +VP L+ L L N ++ V
Sbjct: 227 EISDYALEGLQSLE--------SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGP 278
Query: 92 GALASLSHLKSLDLSHN----LISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRA 147
G A++ HLK L L++ I FA +L L+ L + ++ L+FI AF L
Sbjct: 279 GDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDIT--NNPRLSFIHPRAFHHLPQ 336
Query: 148 LRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDN 207
+ +L LN+N L L + T L L + ++ NP C C I W A T V E +
Sbjct: 337 METLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWAN--ATGTRVRFIEPQS 394
Query: 208 IACTSPHVLKGTPLSRLP-------PLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVD 260
C P L+ P+ +P LP +P S+ PS ++ G + LHC
Sbjct: 395 TLCAEPPDLQRLPVREVPFREMTDHCLPLISPR---SFPPS---LQVASGESMVLHCRAL 448
Query: 261 GQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKL 320
+P P+++W P+G+ +T + G R++ + G+L +
Sbjct: 449 AEPEPEIYW--VTPAGL-RLTPAHAGR---------------RYRVYPEGTLELRRVTAE 490
Query: 321 EEGTYSCLATNELGSAESSVDV----ALATPG 348
E G Y+C+A N +G+ +V V AL PG
Sbjct: 491 EAGLYTCVAQNLVGADTKTVSVVVGRALLQPG 522
Score = 71.2 bits (173), Expect = 2e-12
Identities = 55/171 (32%), Positives = 73/171 (42%), Gaps = 33/171 (19%)
Query: 19 CPEPCDCGEKYGFQ---------IADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGA 69
CP C C + + DC L +VPP PA TL
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTL-------------- 74
Query: 70 FREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKM 129
LLQS N I V L L++L LDLS N SD D H L L L +
Sbjct: 75 -----LLQS-----NSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHL 124
Query: 130 DSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180
+ N+LT + +F L +L+ L LNHN+L+ +A F+ L+ L L +N N
Sbjct: 125 EENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSN 175
Score = 57.4 bits (137), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%)
Query: 47 GFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLS 106
G+ AN+T L LS N + F +P L SL L N++ + + A L+ L+ L L+
Sbjct: 90 GYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLN 149
Query: 107 HNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTF 166
HN + A LS L L ++SN L I F L L L + N++ + + F
Sbjct: 150 HNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNF 209
Query: 167 TPLTALSHL 175
PL L L
Sbjct: 210 RPLANLRSL 218
Score = 55.8 bits (133), Expect = 7e-08
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 4/129 (3%)
Query: 54 TLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLIS-- 111
+L L N+L L + +F + LQ L+L HN++ +A A + LS+L L L+ NL+
Sbjct: 121 SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI 180
Query: 112 DFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTA 171
D W ++ L L++L + N++ I FR L LRSL L L +++ L +
Sbjct: 181 DSRWFEM--LPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQS 238
Query: 172 LSHLQINEN 180
L L +N
Sbjct: 239 LESLSFYDN 247
Score = 55.1 bits (131), Expect = 1e-07
Identities = 41/132 (31%), Positives = 66/132 (50%), Gaps = 6/132 (4%)
Query: 50 ANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH-N 108
+N+ L L++N L + F +P L+ L + N++ + L++L+SL L+ N
Sbjct: 165 SNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMN 224
Query: 109 L--ISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTF 166
L ISD+A L L +L+ L N+L +PR A + L+ L LN N L + G F
Sbjct: 225 LREISDYA---LEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDF 281
Query: 167 TPLTALSHLQIN 178
+ L L +N
Sbjct: 282 ANMLHLKELGLN 293
>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
Length = 334
Score = 101 bits (251), Expect = 1e-21
Identities = 71/207 (34%), Positives = 92/207 (44%), Gaps = 3/207 (1%)
Query: 16 AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPL 75
A CPE C C +A C+ L +VPPG + L L NR+ LP GAF
Sbjct: 40 APDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGA 96
Query: 76 LQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELT 135
LQ L L N + +V A L L+ LDLS N + A L AL+ L + N L
Sbjct: 97 LQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLA 156
Query: 136 FIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWA 195
+ A +L LRSL L N L LA G L AL L + NP+ C C + L W
Sbjct: 157 RLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWL 216
Query: 196 LTTAVSIPEQDNIACTSPHVLKGTPLS 222
+ E + + C P L +PL+
Sbjct: 217 RRHPLPASEAETVLCVWPGRLTLSPLT 243
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 100 bits (249), Expect = 3e-21
Identities = 75/262 (28%), Positives = 108/262 (41%), Gaps = 44/262 (16%)
Query: 15 LAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVP 74
+A ACP PC C Y C +R L SVP G +V ++L N + L E +F +
Sbjct: 23 VALACPHPCAC---YVPSEVHCTFRSLASVPAGIAKHVERINLGFNSIQALSETSFAGLT 79
Query: 75 LLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNEL 134
L+ L + NEI ++ GAL LS L+ S+N + L LS L L +D N++
Sbjct: 80 KLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITGQTLQGLSNLMRLHIDHNKI 139
Query: 135 TFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLT------------------------ 170
FI AF L +LR L L N LH L TF+ T
Sbjct: 140 EFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYFRLSTIRHLYLAENMVRTLP 199
Query: 171 --------ALSHLQINENPFDCTCGIVWLKTW-ALTTAVSIPEQDN--------IACTSP 213
L +L + NP+ C C + W W A + + ++D C SP
Sbjct: 200 ASMLRNMPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGILKCKKDKAYEGGQLCAMCFSP 259
Query: 214 HVLKGTPLSRLPPLPCSAPSVQ 235
L + +L + C PS++
Sbjct: 260 KKLYKHEIHKLKDMTCLKPSIE 281
Score = 44.7 bits (104), Expect = 2e-04
Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 13/95 (13%)
Query: 253 LALHCDVDGQPAPQLHWHIQIPSG-IVEITSPNVGTDGRALPGTPVASSQPRFQAFANGS 311
L + C G P P++ W +P G +V + + GR R+ F NG+
Sbjct: 2261 LKVDCVATGLPNPEISW--SLPDGSLVNSFMQSDDSGGRT----------KRYVVFNNGT 2308
Query: 312 LLIPDFGKLEEGTYSCLATNELGSAESSVDVALAT 346
L + G EEG Y+C A N++G E V V + T
Sbjct: 2309 LYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVT 2343
Score = 42.0 bits (97), Expect = 0.001
Identities = 27/108 (25%), Positives = 41/108 (37%), Gaps = 23/108 (21%)
Query: 238 YQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPV 297
+Q + L PG + +HC P P + W + GT +
Sbjct: 2050 HQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLG--------------------DGTQI 2089
Query: 298 ASSQ---PRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDV 342
SQ F NG+L I + + G Y C+A N +GSA +V +
Sbjct: 2090 RPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQL 2137
Score = 40.4 bits (93), Expect = 0.003
Identities = 38/159 (23%), Positives = 60/159 (37%), Gaps = 34/159 (21%)
Query: 238 YQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPV 297
+ P + G ++L+C G P P L W + PN GT +
Sbjct: 2545 HDPISEKITAMAGHTISLNCSAAGTPTPSLVWVL-----------PN---------GTDL 2584
Query: 298 ASSQP--RFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGED-- 353
S Q RF A+G L I ++ G Y C+A N G E V + + E +
Sbjct: 2585 QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYH 2644
Query: 354 TLGRRFHGK----------AVEGKGCYTVDNEVQPSGPE 382
L +G+ A +G+ +T+ N + GP+
Sbjct: 2645 NLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQ 2683
Score = 38.5 bits (88), Expect = 0.012
Identities = 21/91 (23%), Positives = 40/91 (43%), Gaps = 20/91 (21%)
Query: 250 GFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFAN 309
G V+ + C+ G+P P++ W + + +P +S ++Q + +
Sbjct: 2361 GDVVTVACEAKGEPMPKVTW---------------LSPTNKVIP-----TSSEKYQIYQD 2400
Query: 310 GSLLIPDFGKLEEGTYSCLATNELGSAESSV 340
G+LLI + + G Y+CL N G +V
Sbjct: 2401 GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTV 2431
Score = 38.1 bits (87), Expect = 0.015
Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 17/89 (19%)
Query: 246 ELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQ 305
++R G L L C G P P++ W + I + S R +
Sbjct: 2157 DVRYGGTLKLDCSASGDPWPRILWRLPSKRMI-----------------DALFSFDSRIK 2199
Query: 306 AFANGSLLIPDFGKLEEGTYSCLATNELG 334
FANG+L++ + G Y C+A N++G
Sbjct: 2200 VFANGTLVVKSVTDKDAGDYLCVARNKVG 2228
Score = 36.6 bits (83), Expect = 0.045
Identities = 19/56 (33%), Positives = 28/56 (50%)
Query: 309 NGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFHGKAV 364
NG+L IP + G Y C+A N+ G+ +V + + G G GRR KA+
Sbjct: 633 NGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRPGAKAL 688
Score = 32.3 bits (72), Expect = 0.85
Identities = 24/96 (25%), Positives = 39/96 (40%), Gaps = 17/96 (17%)
Query: 250 GFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFAN 309
G +A+ C G PAPQ+ W I + + SP G R N
Sbjct: 1965 GDTIAMECLAKGTPAPQISW-IFPDRRVWQTVSPVEG----------------RITLHEN 2007
Query: 310 GSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALA 345
+L I + + G Y C+A+N G+ ++ + +A
Sbjct: 2008 RTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVA 2043
Score = 32.3 bits (72), Expect = 0.85
Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 18/95 (18%)
Query: 255 LHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLI 314
+ C +G P P++ W P G+V + +P G R NGSL I
Sbjct: 2464 IDCKAEGIPTPRVLW--AFPEGVV-LPAPYYGN---------------RITVHGNGSLDI 2505
Query: 315 PDFGKLEEGTYSCLATNELGSAESSVDVALATPGE 349
K + C+A NE G A + + + P E
Sbjct: 2506 RSLRKSDSVQLVCMARNEGGEARLILQLTVLEPME 2540
Score = 31.2 bits (69), Expect = 1.9
Identities = 20/75 (26%), Positives = 29/75 (38%), Gaps = 17/75 (22%)
Query: 257 CDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPD 316
C+ G+P P + W V T P T + RF+ NG+L+I
Sbjct: 1875 CEATGKPKPFVTW-------------TKVSTGALMTPNTRIQ----RFEVLKNGTLVIRK 1917
Query: 317 FGKLEEGTYSCLATN 331
+ G Y C A+N
Sbjct: 1918 VQVQDRGQYMCTASN 1932
Score = 31.2 bits (69), Expect = 1.9
Identities = 34/128 (26%), Positives = 48/128 (37%), Gaps = 24/128 (18%)
Query: 217 KGTPLSRLP----PLPCSAPSVQLSYQPSQDGAEL-----RPGFVLALHCDVDGQPAPQL 267
+GT + R+ P S P + ++Y P RPG + L+C G P +
Sbjct: 2706 RGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADI 2765
Query: 268 HWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSC 327
W + S + G R L G Q GSL I + + G Y C
Sbjct: 2766 TWELPDKSHL------KAGVQAR-LYGNRFLHPQ--------GSLTIQHATQRDAGFYKC 2810
Query: 328 LATNELGS 335
+A N LGS
Sbjct: 2811 MAKNILGS 2818
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 99.4 bits (246), Expect = 6e-21
Identities = 69/191 (36%), Positives = 90/191 (47%), Gaps = 3/191 (1%)
Query: 51 NVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLI 110
N+T LSL N L LP G F P L L L HN++ TVA G A LS+L+SL LS+N I
Sbjct: 266 NLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAI 325
Query: 111 SDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLT 170
+ +L L L + SN LT + F++L L L L+ N+L TL EG F
Sbjct: 326 THLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNY 385
Query: 171 ALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKG--TPLSRLPPLP 228
L +L ++ NP+ C C + +L W L C P LKG P L
Sbjct: 386 NLFNLALHGNPWQCDCHLAYLFNW-LQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLV 444
Query: 229 CSAPSVQLSYQ 239
C L +Q
Sbjct: 445 CPVTRDHLGFQ 455
Score = 78.6 bits (192), Expect = 1e-14
Identities = 43/126 (34%), Positives = 71/126 (56%)
Query: 55 LSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFA 114
L+L+ N L LPEG F+ + L+SL L N+++ + L+HLK+L+L+ NL++
Sbjct: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185
Query: 115 WSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSH 174
H L++LQ LK+ +N L+ +P+ F L +L+ L L+ N + L F+ L L
Sbjct: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
Query: 175 LQINEN 180
L + N
Sbjct: 246 LWLQRN 251
Score = 73.9 bits (180), Expect = 3e-13
Identities = 47/130 (36%), Positives = 65/130 (50%)
Query: 51 NVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLI 110
++ TL LS N L GLP+G F ++ LQ L+L N I + + L L+ L L N I
Sbjct: 194 SLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAI 253
Query: 111 SDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLT 170
+ S +L L L + N L +P F L L L HN+L T+AEGTF L+
Sbjct: 254 THLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLS 313
Query: 171 ALSHLQINEN 180
L L ++ N
Sbjct: 314 NLRSLMLSYN 323
Score = 70.5 bits (171), Expect = 3e-12
Identities = 58/201 (28%), Positives = 92/201 (45%), Gaps = 30/201 (14%)
Query: 6 LLWWALLLGL--AQACPEPCDCGEKYGFQIADCAYRDLESVP---PGFPANVTTLSLSAN 60
LLW +LLL AQ CP CDC + F C+ +L +VP P + N+ + S
Sbjct: 7 LLWTSLLLLARPAQPCPMGCDCFVQEVF----CSDEELATVPLDIPPYTKNIIFVETSFT 62
Query: 61 RL--------PGLPE-------------GAFREVPLLQSLWLAHNEIRTVAAGALASLSH 99
L P L + AF +P L+ L + + ++ ++L+
Sbjct: 63 TLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTS 122
Query: 100 LKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLH 159
L L L+ N++ +L+AL+ L + N+L +PR F+ L L++L L N L
Sbjct: 123 LGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLA 182
Query: 160 TLAEGTFTPLTALSHLQINEN 180
L E F PLT+L L+++ N
Sbjct: 183 QLPEELFHPLTSLQTLKLSNN 203
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 99.4 bits (246), Expect = 6e-21
Identities = 86/296 (29%), Positives = 136/296 (45%), Gaps = 29/296 (9%)
Query: 51 NVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH--N 108
N+ ++S NRL +P A ++V L+ L L N I + G +++ HLK L +++
Sbjct: 237 NLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPE 296
Query: 109 LISDFAWSDLHNLSALQLLKMDSN-ELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFT 167
LIS + + + NL L+ ++ +N L++I +AF L L SL LN N L L GT
Sbjct: 297 LISIDSLA-VDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIE 355
Query: 168 PLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRL--- 224
L L + I+ NP C C I W+ T + E D++ C P +G + ++
Sbjct: 356 SLPNLKEISIHSNPIRCDCVIRWMN--MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFR 413
Query: 225 PPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPN 284
+ P + PS E G ++ HC +P P+++W PSG + PN
Sbjct: 414 DMMEICLPLIAPESFPSNLNVE--AGSYVSFHCRATAEPQPEIYW--ITPSG--QKLLPN 467
Query: 285 VGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSV 340
TD +F + G+L I E G Y+C+ATN +G+ SV
Sbjct: 468 TLTD--------------KFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSV 509
Score = 65.5 bits (158), Expect = 9e-11
Identities = 55/176 (31%), Positives = 82/176 (46%), Gaps = 19/176 (10%)
Query: 48 FPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH 107
FP N+T L LS N L + +++P L S++L N++ + L+ LS+L+ L ++H
Sbjct: 90 FPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINH 149
Query: 108 NLISDF---AWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEG 164
NL+S A+ LHNL L L +SN L I F +L L L + N + + +
Sbjct: 150 NLLSTISPGAFIGLHNLLRLHL---NSNRLQMINSKWFDALPNLEILMIGENPIIRIKDM 206
Query: 165 TFTPLTALSHL-----QINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHV 215
F PL L L + E P + G+ L+ SI DN PHV
Sbjct: 207 NFKPLINLRSLVIAGINLTEIPDNALVGLENLE--------SISFYDNRLIKVPHV 254
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 99.4 bits (246), Expect = 6e-21
Identities = 86/296 (29%), Positives = 136/296 (45%), Gaps = 29/296 (9%)
Query: 51 NVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH--N 108
N+ ++S NRL +P A ++V L+ L L N I + G +++ HLK L +++
Sbjct: 237 NLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPE 296
Query: 109 LISDFAWSDLHNLSALQLLKMDSN-ELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFT 167
LIS + + + NL L+ ++ +N L++I +AF L L SL LN N L L GT
Sbjct: 297 LISIDSLA-VDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIE 355
Query: 168 PLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRL--- 224
L L + I+ NP C C I W+ T + E D++ C P +G + ++
Sbjct: 356 SLPNLKEISIHSNPIRCDCVIRWMN--MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFR 413
Query: 225 PPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPN 284
+ P + PS E G ++ HC +P P+++W PSG + PN
Sbjct: 414 DMMEICLPLIAPESFPSNLNVE--AGSYVSFHCRATAEPQPEIYW--ITPSG--QKLLPN 467
Query: 285 VGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSV 340
TD +F + G+L I E G Y+C+ATN +G+ SV
Sbjct: 468 TLTD--------------KFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSV 509
Score = 65.5 bits (158), Expect = 9e-11
Identities = 55/176 (31%), Positives = 82/176 (46%), Gaps = 19/176 (10%)
Query: 48 FPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH 107
FP N+T L LS N L + +++P L S++L N++ + L+ LS+L+ L ++H
Sbjct: 90 FPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINH 149
Query: 108 NLISDF---AWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEG 164
NL+S A+ LHNL L L +SN L I F +L L L + N + + +
Sbjct: 150 NLLSTISPGAFIGLHNLLRLHL---NSNRLQMINSKWFDALPNLEILMIGENPIIRIKDM 206
Query: 165 TFTPLTALSHL-----QINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHV 215
F PL L L + E P + G+ L+ SI DN PHV
Sbjct: 207 NFKPLINLRSLVIAGINLTEIPDNALVGLENLE--------SISFYDNRLIKVPHV 254
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 99.4 bits (246), Expect = 6e-21
Identities = 86/296 (29%), Positives = 136/296 (45%), Gaps = 29/296 (9%)
Query: 51 NVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH--N 108
N+ ++S NRL +P A ++V L+ L L N I + G +++ HLK L +++
Sbjct: 237 NLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPE 296
Query: 109 LISDFAWSDLHNLSALQLLKMDSN-ELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFT 167
LIS + + + NL L+ ++ +N L++I +AF L L SL LN N L L GT
Sbjct: 297 LISIDSLA-VDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIE 355
Query: 168 PLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRL--- 224
L L + I+ NP C C I W+ T + E D++ C P +G + ++
Sbjct: 356 SLPNLKEISIHSNPIRCDCVIRWMN--MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFR 413
Query: 225 PPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPN 284
+ P + PS E G ++ HC +P P+++W PSG + PN
Sbjct: 414 DMMEICLPLIAPESFPSNLNVE--AGSYVSFHCRATAEPQPEIYW--ITPSG--QKLLPN 467
Query: 285 VGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSV 340
TD +F + G+L I E G Y+C+ATN +G+ SV
Sbjct: 468 TLTD--------------KFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSV 509
Score = 65.5 bits (158), Expect = 9e-11
Identities = 55/176 (31%), Positives = 82/176 (46%), Gaps = 19/176 (10%)
Query: 48 FPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSH 107
FP N+T L LS N L + +++P L S++L N++ + L+ LS+L+ L ++H
Sbjct: 90 FPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINH 149
Query: 108 NLISDF---AWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEG 164
NL+S A+ LHNL L L +SN L I F +L L L + N + + +
Sbjct: 150 NLLSTISPGAFIGLHNLLRLHL---NSNRLQMINSKWFDALPNLEILMIGENPIIRIKDM 206
Query: 165 TFTPLTALSHL-----QINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHV 215
F PL L L + E P + G+ L+ SI DN PHV
Sbjct: 207 NFKPLINLRSLVIAGINLTEIPDNALVGLENLE--------SISFYDNRLIKVPHV 254
>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
Length = 513
Score = 99.0 bits (245), Expect = 7e-21
Identities = 99/357 (27%), Positives = 138/357 (38%), Gaps = 47/357 (13%)
Query: 11 LLLGL-AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRL----PG- 64
LLL L A CP C C Y + +C L VP G P TL L N + PG
Sbjct: 14 LLLPLRAAGCPAACRC---YSATV-ECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGA 69
Query: 65 -------------------LPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDL 105
L GAFR P L L L N +R + +GA L+ L+ L L
Sbjct: 70 LAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYL 129
Query: 106 SHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGT 165
+ N ++ +L LQ L + N + + A L +L L L+ N+L T++
Sbjct: 130 AGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREA 189
Query: 166 FTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSI--PEQDNIACTSPHVLKGTPLSR 223
PL +L L++ ENP+ C C + WL W + I C P L L
Sbjct: 190 LQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLD 249
Query: 224 L--PPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEIT 281
+ L C PSV + QP + A L G L + C G P P + W ++
Sbjct: 250 VSHSSLICIPPSVHV--QPLELTANL--GEDLRVACQASGYPQPLVTWR--------KVP 297
Query: 282 SPNVGTD--GRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSA 336
P G L G + +G L + + G Y C A+N G+A
Sbjct: 298 QPREGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAA 354
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 97.8 bits (242), Expect = 2e-20
Identities = 59/158 (37%), Positives = 83/158 (52%), Gaps = 6/158 (3%)
Query: 19 CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78
C PC C G + DC+ + L +VP G A L +S N + LPE AF+ P L+
Sbjct: 29 CAAPCSCD---GDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEE 85
Query: 79 LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138
L LA N++ + AL+ L LK L L +N + + LSALQ L++D+N +T +P
Sbjct: 86 LQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVP 145
Query: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQ 176
D+F L LR L L+ N +L E PL+ L LQ
Sbjct: 146 EDSFEGLVQLRHLWLDDN---SLTEVPVHPLSNLPTLQ 180
Score = 60.5 bits (145), Expect = 3e-09
Identities = 42/130 (32%), Positives = 69/130 (53%), Gaps = 7/130 (5%)
Query: 54 TLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLIS-- 111
+L L AN + +PE +F + L+ LWL N + V L++L L++L L+ N IS
Sbjct: 133 SLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSI 192
Query: 112 -DFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLT 170
DFA++ NLS+L +L + +N++ + + F L L +L LN+N L + L
Sbjct: 193 PDFAFT---NLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ-AIKALP 248
Query: 171 ALSHLQINEN 180
+L L + N
Sbjct: 249 SLKELGFHSN 258
Score = 54.3 bits (129), Expect = 2e-07
Identities = 48/191 (25%), Positives = 79/191 (41%), Gaps = 32/191 (16%)
Query: 15 LAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPA--NVTTLSLSANRLPGLPEGAFRE 72
L+Q C + D + D Y +L P A ++ L +N + +P+GAF
Sbjct: 216 LSQHCFDGLD-----NLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDG 270
Query: 73 VPLLQSLWLAHNEIRTVAAGALASLS-----------------------HLKSLDLSHNL 109
PLL+++ L N + V A +LS HL+SL L+
Sbjct: 271 NPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTK 330
Query: 110 ISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPL 169
IS + L+ L + N + +P +F AL + L N+++ + EGTF L
Sbjct: 331 ISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGL 388
Query: 170 TALSHLQINEN 180
+L L ++ N
Sbjct: 389 ISLRILDLSRN 399
Score = 48.9 bits (115), Expect = 9e-06
Identities = 39/120 (32%), Positives = 52/120 (43%), Gaps = 3/120 (2%)
Query: 54 TLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDF 113
TL LS N + LP +F L+ + L N+I + G L L+ LDLS NLI +
Sbjct: 347 TLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEI 404
Query: 114 AWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALS 173
L + L + NELT P + L L+ L N LA F L +LS
Sbjct: 405 HSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK-LVGNFKLKEALAAKDFVNLRSLS 463
Score = 44.7 bits (104), Expect = 2e-04
Identities = 28/104 (26%), Positives = 56/104 (53%), Gaps = 1/104 (0%)
Query: 25 CGEKYGFQIADCAYRDLESVPPGFPAN-VTTLSLSANRLPGLPEGAFREVPLLQSLWLAH 83
C E+ + D +Y ++ +P + + +SL N++ + EG F+ + L+ L L+
Sbjct: 339 CQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSR 398
Query: 84 NEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLL 127
N I + + A A+L + +LD+S N ++ F L+ L+ L+L+
Sbjct: 399 NLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLV 442
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 96.3 bits (238), Expect = 5e-20
Identities = 113/460 (24%), Positives = 162/460 (35%), Gaps = 132/460 (28%)
Query: 16 AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPAN------------------------ 51
A +CP C C + I C RDL VP P N
Sbjct: 54 ATSCPVACSCSNQASRVI--CTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRH 111
Query: 52 ------------------------VTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIR 87
+ TL L NRL +P AF + L+ LWL +N I
Sbjct: 112 LEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIE 171
Query: 88 TVAAGALASLSHLKSLDLSH----NLISDFAWSDLHNLSALQL----------------- 126
++ + A + L+ LDL IS+ A+ L NL L L
Sbjct: 172 SIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRL 231
Query: 127 --LKMDSNELTFI------------------------PRDAFRSLRALRSLQLNHNRLHT 160
L++ N L I R+AF L++L L L+HN L +
Sbjct: 232 EELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMS 291
Query: 161 LAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIA--CTSPHVLKG 218
L FTPL L + +N NP+ C C ++WL W T +P C +P LKG
Sbjct: 292 LPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKET---VPSNTTCCARCHAPAGLKG 348
Query: 219 TPLSRLPP--LPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSG 276
+ L C AP + +P D + G L C G ++W P+G
Sbjct: 349 RYIGELDQSHFTCYAPVI---VEPPTD-LNVTEGMAAELKCRT-GTSMTSVNW--LTPNG 401
Query: 277 IVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELG-- 334
+ T G S + R +G+L + + G Y+C+ TN G
Sbjct: 402 -------TLMTHG---------SYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNT 445
Query: 335 SAESSVDVALATP---GEGGEDTLGRRFHGKAVEGKGCYT 371
+A ++++V+ P G G G G G G YT
Sbjct: 446 TASATLNVSAVDPVAAGGTGSGGGGPGGSGGVGGGSGGYT 485
>gi|239752702 PREDICTED: leucine rich repeat containing 38, partial
[Homo sapiens]
Length = 254
Score = 95.9 bits (237), Expect = 6e-20
Identities = 58/180 (32%), Positives = 90/180 (50%), Gaps = 1/180 (0%)
Query: 35 DCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGAL 94
DC R L SVP FP +V L ++ NR+ +PE F L L +N +R++ G
Sbjct: 1 DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60
Query: 95 ASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLN 154
+ + L LDLS+N ++ + L L + +N L + DAF +L +L+ L+LN
Sbjct: 61 SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120
Query: 155 HNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPE-QDNIACTSP 213
N L +L+ L AL L+++ NP+ C C L +W A +P+ D I C+ P
Sbjct: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 95.5 bits (236), Expect = 8e-20
Identities = 95/403 (23%), Positives = 153/403 (37%), Gaps = 100/403 (24%)
Query: 6 LLWWALLLGLA---QACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRL 62
+L++ L+G+A Q CP+ C C CA + L VPP L L+ N +
Sbjct: 4 ILFYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFV 63
Query: 63 PGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDF------AWS 116
+ F + L L L+ N I + A A L +L++L L+ N ++ S
Sbjct: 64 TNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLS 123
Query: 117 DLHNL------------------SALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRL 158
+LH+L AL+ L + N L IP DA + +L +L L+HN +
Sbjct: 124 NLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMI 183
Query: 159 HTLAEGTFTPLTALSHLQINE-----------------------------------NPFD 183
+ +GTF+ L ++ L + NP
Sbjct: 184 DNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLH 243
Query: 184 CTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLP--PLPCSAPSVQLSYQPS 241
C C ++WL+ + E D C SP +L G +P C P + +
Sbjct: 244 CNCELLWLRRLS-------REDDLETCASPPLLTGRYFWSIPEEEFLCEPPLI------T 290
Query: 242 QDGAELR--PGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVAS 299
+ E+R G L C G P P +HW + +G+ + S
Sbjct: 291 RHTHEMRVLEGQRATLRCKARGDPEPAIHW---------------ISPEGKLI------S 329
Query: 300 SQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDV 342
+ R + NG+L I + G ++C+A+N G A VD+
Sbjct: 330 NATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDL 372
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,023,513
Number of Sequences: 37866
Number of extensions: 1000442
Number of successful extensions: 5802
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 289
Number of HSP's successfully gapped in prelim test: 146
Number of HSP's that attempted gapping in prelim test: 2932
Number of HSP's gapped (non-prelim): 1899
length of query: 428
length of database: 18,247,518
effective HSP length: 105
effective length of query: 323
effective length of database: 14,271,588
effective search space: 4609722924
effective search space used: 4609722924
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.