Search of human proteins with 41406057

Search of human proteins with 41406057

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41406057 amyloid beta A4 protein isoform c precursor [Homo
sapiens]
         (695 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sa...  1407   0.0  
gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sa...  1340   0.0  
gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sap...  1283   0.0  
gi|209915570 amyloid beta A4 protein isoform e precursor [Homo s...  1254   0.0  
gi|209915573 amyloid beta A4 protein isoform f precursor [Homo s...  1130   0.0  
gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform ...   666   0.0  
gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform ...   638   0.0  
gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 ...   636   0.0  
gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor...   445   e-125
gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor ...   442   e-124
gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform ...   383   e-106
gi|17975763 myelin transcription factor 1 [Homo sapiens]               59   2e-08
gi|60498973 myelin transcription factor 1-like [Homo sapiens]          57   6e-08
gi|55956788 nucleolin [Homo sapiens]                                   54   6e-07
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    54   6e-07
gi|210032580 SET domain containing 1B [Homo sapiens]                   53   8e-07
gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens]        52   2e-06
gi|61097912 nucleolar protein with MIF4G domain 1 [Homo sapiens]       51   3e-06
gi|87299628 biorientation of chromosomes in cell division 1-like...    51   4e-06
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...    50   5e-06
gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens]        50   5e-06
gi|4757900 calreticulin precursor [Homo sapiens]                       50   9e-06
gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 famil...    50   9e-06
gi|38569484 kinesin family member 21A [Homo sapiens]                   49   2e-05
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]     48   3e-05
gi|239756368 PREDICTED: similar to acidic (leucine-rich) nuclear...    48   3e-05
gi|239750893 PREDICTED: similar to acidic (leucine-rich) nuclear...    48   3e-05
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]           48   3e-05
gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]           48   3e-05
gi|115529449 upstream binding transcription factor, RNA polymera...    47   5e-05

>gi|41406057 amyloid beta A4 protein isoform c precursor [Homo
           sapiens]
          Length = 695

 Score = 1407 bits (3641), Expect = 0.0
 Identities = 695/695 (100%), Positives = 695/695 (100%)

Query: 1   MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
           MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
Sbjct: 1   MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60

Query: 61  TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
           TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
Sbjct: 61  TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120

Query: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
           EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Sbjct: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180

Query: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
           GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Sbjct: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240

Query: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAV 300
           EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAV
Sbjct: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAV 300

Query: 301 DKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF 360
           DKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF
Sbjct: 301 DKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF 360

Query: 361 QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLK 420
           QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLK
Sbjct: 361 QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLK 420

Query: 421 KYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVA 480
           KYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVA
Sbjct: 421 KYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVA 480

Query: 481 EEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSL 540
           EEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSL
Sbjct: 481 EEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSL 540

Query: 541 DDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEF 600
           DDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEF
Sbjct: 541 DDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEF 600

Query: 601 RHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGV 660
           RHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGV
Sbjct: 601 RHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGV 660

Query: 661 VEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 695
           VEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 661 VEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 695


>gi|41406055 amyloid beta A4 protein isoform b precursor [Homo
           sapiens]
          Length = 751

 Score = 1340 bits (3469), Expect = 0.0
 Identities = 676/751 (90%), Positives = 679/751 (90%), Gaps = 56/751 (7%)

Query: 1   MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
           MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
Sbjct: 1   MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60

Query: 61  TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
           TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
Sbjct: 61  TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120

Query: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
           EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Sbjct: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180

Query: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
           GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Sbjct: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240

Query: 241 EADDDEDDEDGDEVEEEAEEPYEEA--------TERTTSIATTTTTTTESVEEVVR---- 288
           EADDDEDDEDGDEVEEEAEEPYEEA        T  TT+  +      E   E       
Sbjct: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC 300

Query: 289 --------------------------------------------VPTTAASTPDAVDKYL 304
                                                       +PTTAASTPDAVDKYL
Sbjct: 301 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYL 360

Query: 305 ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKV 364
           ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKV
Sbjct: 361 ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKV 420

Query: 365 ESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVR 424
           ESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVR
Sbjct: 421 ESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVR 480

Query: 425 AEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ 484
           AEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ
Sbjct: 481 AEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ 540

Query: 485 DEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQ 544
           DEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQ
Sbjct: 541 DEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQ 600

Query: 545 PWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDS 604
           PWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDS
Sbjct: 601 PWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDS 660

Query: 605 GYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVD 664
           GYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVD
Sbjct: 661 GYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVD 720

Query: 665 AAVTPEERHLSKMQQNGYENPTYKFFEQMQN 695
           AAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 721 AAVTPEERHLSKMQQNGYENPTYKFFEQMQN 751


>gi|4502167 amyloid beta A4 protein isoform a precursor [Homo
           sapiens]
          Length = 770

 Score = 1283 bits (3321), Expect = 0.0
 Identities = 657/770 (85%), Positives = 665/770 (86%), Gaps = 75/770 (9%)

Query: 1   MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
           MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
Sbjct: 1   MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60

Query: 61  TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
           TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
Sbjct: 61  TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120

Query: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
           EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Sbjct: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180

Query: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA----- 235
           GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA     
Sbjct: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240

Query: 236 ------------EVEEEEADDDEDDEDG------------DEVEEEAEEPYEEATER--- 268
                       EVEEE  +  E+  +             + VEE   E   E  E    
Sbjct: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC 300

Query: 269 -------------------------------------------TTSIATTTTTTTESVEE 285
                                                        S +   TT      +
Sbjct: 301 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD 360

Query: 286 VVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA 345
            V++PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
Sbjct: 361 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA 420

Query: 346 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL 405
           KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
Sbjct: 421 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL 480

Query: 406 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER 465
           QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
Sbjct: 481 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER 540

Query: 466 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET 525
           MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
Sbjct: 541 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET 600

Query: 526 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN 585
           KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
Sbjct: 601 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN 660

Query: 586 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL 645
           IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
Sbjct: 661 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL 720

Query: 646 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 695
           VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 721 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 770


>gi|209915570 amyloid beta A4 protein isoform e precursor [Homo
           sapiens]
          Length = 639

 Score = 1254 bits (3244), Expect = 0.0
 Identities = 621/621 (100%), Positives = 621/621 (100%)

Query: 75  EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 134
           EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK
Sbjct: 19  EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78

Query: 135 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 194
           FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD
Sbjct: 79  FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138

Query: 195 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 254
           NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV
Sbjct: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 198

Query: 255 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHA 314
           EEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHA
Sbjct: 199 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHA 258

Query: 315 HFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANE 374
           HFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANE
Sbjct: 259 HFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANE 318

Query: 375 RQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTL 434
           RQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTL
Sbjct: 319 RQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTL 378

Query: 435 KHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKE 494
           KHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKE
Sbjct: 379 KHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKE 438

Query: 495 QNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSV 554
           QNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSV
Sbjct: 439 QNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSV 498

Query: 555 PANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLV 614
           PANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLV
Sbjct: 499 PANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLV 558

Query: 615 FFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHL 674
           FFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHL
Sbjct: 559 FFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHL 618

Query: 675 SKMQQNGYENPTYKFFEQMQN 695
           SKMQQNGYENPTYKFFEQMQN
Sbjct: 619 SKMQQNGYENPTYKFFEQMQN 639


>gi|209915573 amyloid beta A4 protein isoform f precursor [Homo
           sapiens]
          Length = 714

 Score = 1130 bits (2924), Expect = 0.0
 Identities = 583/696 (83%), Positives = 591/696 (84%), Gaps = 75/696 (10%)

Query: 75  EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 134
           EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK
Sbjct: 19  EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78

Query: 135 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 194
           FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD
Sbjct: 79  FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138

Query: 195 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA-----------------EV 237
           NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA                 EV
Sbjct: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 198

Query: 238 EEEEADDDEDDEDG------------DEVEEEAEEPYEEATER----------------- 268
           EEE  +  E+  +             + VEE   E   E  E                  
Sbjct: 199 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG 258

Query: 269 -----------------------------TTSIATTTTTTTESVEEVVRVPTTAASTPDA 299
                                          S +   TT      + V++PTTAASTPDA
Sbjct: 259 KCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDA 318

Query: 300 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 359
           VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH
Sbjct: 319 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 378

Query: 360 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 419
           FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML
Sbjct: 379 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 438

Query: 420 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 479
           KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV
Sbjct: 439 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 498

Query: 480 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 539
           AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS
Sbjct: 499 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 558

Query: 540 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 599
           LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE
Sbjct: 559 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 618

Query: 600 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 659
           FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG
Sbjct: 619 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 678

Query: 660 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 695
           VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 679 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 714



 Score =  397 bits (1019), Expect = e-110
 Identities = 213/288 (73%), Positives = 215/288 (74%), Gaps = 56/288 (19%)

Query: 1   MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
           MLPGLALLLLAAWTARALEV          E QI       N  + +QN  W     G K
Sbjct: 1   MLPGLALLLLAAWTARALEV--------YPELQITNVV-EANQPVTIQN--WCK--RGRK 47

Query: 61  TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
            C                                           KTHPHFVIPYRCLVG
Sbjct: 48  QC-------------------------------------------KTHPHFVIPYRCLVG 64

Query: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
           EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Sbjct: 65  EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 124

Query: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
           GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Sbjct: 125 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 184

Query: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR 288
           EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR
Sbjct: 185 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR 232


>gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform 3
           [Homo sapiens]
          Length = 695

 Score =  666 bits (1719), Expect = 0.0
 Identities = 362/709 (51%), Positives = 473/709 (66%), Gaps = 48/709 (6%)

Query: 5   LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
           L LLLL   TA AL +         NAG    +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 15  LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74

Query: 57  SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
           +GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+   FV P++
Sbjct: 75  TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132

Query: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176
           CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C  +   L+ YGMLLPCG+
Sbjct: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192

Query: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 236
           D+F G E+VCCP  +   +V   + EED+ +      + DY D  + +    A+ E+  E
Sbjct: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTE 251

Query: 237 VEEEEADDDEDDEDGDEVEEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVRVP 290
              +E  DDED+E+G+EV E+ +  Y+         E  T   +  T + + +   V+VP
Sbjct: 252 AAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVP 309

Query: 291 TTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPK 350
            T   T D VD Y ET  D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPK
Sbjct: 310 PTPLPTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPK 368

Query: 351 ADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPP 410
           A+++ +IQHFQ  V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PP
Sbjct: 369 AERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPP 428

Query: 411 RPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSL 470
           RP  +   L++YVRAE KDR HT++H++HV  VDP+KAAQ++SQVMTHL VI ER NQSL
Sbjct: 429 RPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSL 488

Query: 471 SLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVE 530
           SLLY VP VA+EIQ+E+DELLQ+++       A+M          D    S++ET   V 
Sbjct: 489 SLLYKVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR 531

Query: 531 LLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLTNI 586
              V+ E S +++ P+H F     PA  ENE   V  +      A+  +         N+
Sbjct: 532 ---VSSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENM 585

Query: 587 KTEEISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL 645
             +E  +VK M        G E   + +    ED   +  A+IGL+V  V IATVIVI+L
Sbjct: 586 VIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISL 645

Query: 646 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 694
           VML+K+QY +I HG+VEVD  +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 646 VMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 694


>gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform 2
           [Homo sapiens]
          Length = 751

 Score =  638 bits (1646), Expect = 0.0
 Identities = 367/762 (48%), Positives = 468/762 (61%), Gaps = 98/762 (12%)

Query: 5   LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
           L LLLL   TA AL +         NAG    +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 15  LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74

Query: 57  SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
           +GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+   FV P++
Sbjct: 75  TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132

Query: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176
           CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C  +   L+ YGMLLPCG+
Sbjct: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192

Query: 177 DKFRGVEFVCCPLA-----------EESDNVDSADAEEDDSDVWWGGADT--DYADGSED 223
           D+F G E+VCCP             EE +  +  + EE+D DV+     T  D  D +E 
Sbjct: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEA 252

Query: 224 KVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEE-AEEPYEEATERTTSIATTTTTTTE- 281
            V E  E+EE  E   E+ D   D   GD+  EE   EP  + T     I          
Sbjct: 253 AVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQ 312

Query: 282 ------------------SVEEVVR--------------------------VPTTAASTP 297
                             S  + VR                          +P T   T 
Sbjct: 313 EAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTN 372

Query: 298 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 357
           D VD Y ET  D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++ +I
Sbjct: 373 D-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLI 431

Query: 358 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 417
           QHFQ  V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP  +  
Sbjct: 432 QHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQ 491

Query: 418 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 477
            L++YVRAE KDR HT++H++HV  VDP+KAAQ++SQVMTHL VI ER NQSLSLLY VP
Sbjct: 492 ALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVP 551

Query: 478 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 537
            VA+EIQ+E+DELLQ+++       A+M          D    S++ET   V    V+ E
Sbjct: 552 YVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR---VSSE 591

Query: 538 FSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLTNIKTEEISE 593
            S +++ P+H F     PA  ENE   V  +      A+  +         N+  +E  +
Sbjct: 592 ES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD 648

Query: 594 VK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQ 652
           VK M        G E   + +    ED   +  A+IGL+V  V IATVIVI+LVML+K+Q
Sbjct: 649 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ 708

Query: 653 YTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 694
           Y +I HG+VEVD  +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 709 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 750


>gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1
           [Homo sapiens]
          Length = 763

 Score =  636 bits (1641), Expect = 0.0
 Identities = 371/776 (47%), Positives = 474/776 (61%), Gaps = 114/776 (14%)

Query: 5   LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
           L LLLL   TA AL +         NAG    +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 15  LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74

Query: 57  SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
           +GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+   FV P++
Sbjct: 75  TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132

Query: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176
           CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C  +   L+ YGMLLPCG+
Sbjct: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192

Query: 177 DKFRGVEFVCCPLA-----------EESDNVDSADAEEDDSDVWWGGADT--DYADGSED 223
           D+F G E+VCCP             EE +  +  + EE+D DV+     T  D  D +E 
Sbjct: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEA 252

Query: 224 KVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEE-AEEPYEEATERTTSIATTTTTTTE- 281
            V E  E+EE  E   E+ D   D   GD+  EE   EP  + T     I          
Sbjct: 253 AVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQ 312

Query: 282 ------------------SVEEVVR--------------------------VPTTAASTP 297
                             S  + VR                          +P T   T 
Sbjct: 313 EAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTN 372

Query: 298 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 357
           D VD Y ET  D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++ +I
Sbjct: 373 D-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLI 431

Query: 358 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 417
           QHFQ  V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP  +  
Sbjct: 432 QHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQ 491

Query: 418 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 477
            L++YVRAE KDR HT++H++HV  VDP+KAAQ++SQVMTHL VI ER NQSLSLLY VP
Sbjct: 492 ALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVP 551

Query: 478 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 537
            VA+EIQ+E+DELLQ+++       A+M          D    S++ET   V    V+ E
Sbjct: 552 YVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR---VSSE 591

Query: 538 FSLDDLQPWHSFGADSVPANTENE-VEPVDARPAADRGLTTRPGSGLTNIKTEEI-SEVK 595
            S +++ P+H F     PA  ENE  +P    P            GL   + + I S+ K
Sbjct: 592 ES-EEIPPFHPF--HPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNK 648

Query: 596 MDAEFRHDSGYEVHHQKLVFFAEDVGS-----------------NKGAIIGLMVGGVVIA 638
           +D     D   +V  ++++F AE VG                  +  A+IGL+V  V IA
Sbjct: 649 VDENMVIDETLDV--KEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIA 706

Query: 639 TVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 694
           TVIVI+LVML+K+QY +I HG+VEVD  +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 707 TVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 762


>gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor
           [Homo sapiens]
          Length = 651

 Score =  445 bits (1145), Expect = e-125
 Identities = 273/699 (39%), Positives = 386/699 (55%), Gaps = 79/699 (11%)

Query: 1   MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
           +LP L LLL A     +L   + G A      Q+A  CGRL +H +++ G+W+ DP  ++
Sbjct: 23  LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82

Query: 61  TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119
            C+   + +L+YC+++YPELQI  V +A Q + ++ WC   R     HPH  V+P+RCL 
Sbjct: 83  RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142

Query: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179
           GEFVS+ALLVP+ C+FLHQERMD CE+    H  A+E CS +   LH  GMLLPCG D+F
Sbjct: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202

Query: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239
           RGVE+VCCP     D   S  A  D S   W         GS    VE AE+EE  E   
Sbjct: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250

Query: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDA 299
           +  DD   +    E EEE   P    T       T T   T                 D 
Sbjct: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPT-----------------DG 293

Query: 300 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 359
           VD Y   PG+ +EH  F +AK  LE +   ++++VMREW  A+ Q+KNLPKAD++A+ +H
Sbjct: 294 VDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEH 353

Query: 360 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 419
           FQ  +++LE++ + ERQ+LVETH  RV A++ND+RR ALE ++ ALQA PP+   V   L
Sbjct: 354 FQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLAL 413

Query: 420 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 479
           ++Y+RAEQK+++HTL+H++HV  VDP+KA Q+R QV THL+VI ER+NQSL LL   P +
Sbjct: 414 RRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHL 473

Query: 480 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 539
           A+E++ ++ ELL  E                       L PS  E        P  G  S
Sbjct: 474 AQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGGSS 504

Query: 540 LD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMD 597
            D   LQP  S  AD+     +   E   A P  ++            +   E  E K++
Sbjct: 505 EDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK------------MNPLEQYERKVN 552

Query: 598 AEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKKQY 653
           A      G+  H    Q+        G ++ A+ GL++ G    ++IV+++++L +KK Y
Sbjct: 553 ASV--PRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPY 610

Query: 654 TSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 692
            +I HGVVEVD  +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 611 GAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 649


>gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor
           [Homo sapiens]
          Length = 650

 Score =  442 bits (1136), Expect = e-124
 Identities = 269/699 (38%), Positives = 381/699 (54%), Gaps = 80/699 (11%)

Query: 1   MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
           +LP L LLL A     +L   + G A      Q+A  CGRL +H +++ G+W+ DP  ++
Sbjct: 23  LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82

Query: 61  TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119
            C+   + +L+YC+++YPELQI  V +A Q + ++ WC   R     HPH  V+P+RCL 
Sbjct: 83  RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142

Query: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179
           GEFVS+ALLVP+ C+FLHQERMD CE+    H  A+E CS +   LH  GMLLPCG D+F
Sbjct: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202

Query: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239
           RGVE+VCCP     D   S  A  D S   W         GS    VE AE+EE  E   
Sbjct: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250

Query: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDA 299
           +  DD   +    E EEE   P    T       T T   T                 D 
Sbjct: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPT-----------------DG 293

Query: 300 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 359
           VD Y   PG+ +EH  F +AK  LE +   ++++VMREW  A+ Q+KNLPKAD++A+ +H
Sbjct: 294 VDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEH 353

Query: 360 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 419
           FQ  +++LE++ + ERQ+LVETH  RV A++ND+RR ALE ++ ALQA PP+   V   L
Sbjct: 354 FQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLAL 413

Query: 420 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 479
           ++Y+RAEQK+++HTL+H++HV  VDP+KA Q+R QV THL+VI ER+NQSL LL   P +
Sbjct: 414 RRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHL 473

Query: 480 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 539
           A+E++ ++ ELL  E                       L PS  E        P  G  S
Sbjct: 474 AQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGGSS 504

Query: 540 LD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMD 597
            D   LQP  S   D  P                 +G T +  +     K   + + +  
Sbjct: 505 EDKGGLQPPDS--KDDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYERK 549

Query: 598 AEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKKQY 653
                  G+  H    Q+        G ++ A+ GL++ G    ++IV+++++L +KK Y
Sbjct: 550 VNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPY 609

Query: 654 TSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 692
            +I HGVVEVD  +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 610 GAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648


>gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform 4
           [Homo sapiens]
          Length = 522

 Score =  383 bits (984), Expect = e-106
 Identities = 216/411 (52%), Positives = 278/411 (67%), Gaps = 29/411 (7%)

Query: 289 VPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNL 348
           VP T   T D VD Y ET  D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNL
Sbjct: 135 VPPTPLPTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNL 193

Query: 349 PKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAV 408
           PKA+++ +IQHFQ  V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ 
Sbjct: 194 PKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSD 253

Query: 409 PPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQ 468
           PPRP  +   L++YVRAE KDR HT++H++HV  VDP+KAAQ++SQVMTHL VI ER NQ
Sbjct: 254 PPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQ 313

Query: 469 SLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTT 528
           SLSLLY VP VA+EIQ+E+DELLQ+++       A+M          D    S++ET   
Sbjct: 314 SLSLLYKVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVD 356

Query: 529 VELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLT 584
           V    V+ E S +++ P+H F     PA  ENE   V  +      A+  +         
Sbjct: 357 VR---VSSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDE 410

Query: 585 NIKTEEISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVI 643
           N+  +E  +VK M        G E   + +    ED   +  A+IGL+V  V IATVIVI
Sbjct: 411 NMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVI 470

Query: 644 TLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 694
           +LVML+K+QY +I HG+VEVD  +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 471 SLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 521



 Score =  152 bits (385), Expect = 8e-37
 Identities = 75/123 (60%), Positives = 93/123 (75%), Gaps = 10/123 (8%)

Query: 5   LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
           L LLLL   TA AL +         NAG    +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 15  LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74

Query: 57  SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
           +GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+   FV P++
Sbjct: 75  TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKS--RFVTPFK 132

Query: 117 CLV 119
           CLV
Sbjct: 133 CLV 135


>gi|17975763 myelin transcription factor 1 [Homo sapiens]
          Length = 1121

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 39/135 (28%), Positives = 72/135 (53%), Gaps = 2/135 (1%)

Query: 200 DAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAE 259
           DA  ++S    G    +  D  E++  E  EE+E  E EEEE +++E++E+ +E EEE E
Sbjct: 242 DAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEE 301

Query: 260 EPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPD-AVDKYLETPGDENEHAHFQK 318
           E  EEA         T+ T+ +   E +R P + +  P+ +V   + +  D++E  H +K
Sbjct: 302 EEEEEAAPDVIFQEDTSHTSAQKAPE-LRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRK 360

Query: 319 AKERLEAKHRERMSQ 333
           +    E++ ++ M++
Sbjct: 361 STVTDESEMQDMMTR 375



 Score = 33.9 bits (76), Expect = 0.52
 Identities = 27/112 (24%), Positives = 47/112 (41%), Gaps = 1/112 (0%)

Query: 238 EEEEADDDEDDEDGDEVE-EEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAAST 296
           E  E    E+ E G  ++ E+AEE  E  TER+  +   +     S E   +    +   
Sbjct: 200 EAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEE 259

Query: 297 PDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNL 348
            D  ++  E   +E+E    ++ +E  E +  E   +   E EE E  A ++
Sbjct: 260 EDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDV 311


>gi|60498973 myelin transcription factor 1-like [Homo sapiens]
          Length = 1184

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 32/77 (41%), Positives = 44/77 (57%), Gaps = 2/77 (2%)

Query: 191 EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDED 250
           ++SD  +  D +E+D    +   D D   G ED+  E  + EE  E+EEE+ DDDED ED
Sbjct: 91  DDSDGTEDMDEKEEDEGEEYS-EDND-EPGDEDEEDEEGDREEEEEIEEEDEDDDEDGED 148

Query: 251 GDEVEEEAEEPYEEATE 267
            ++ EEE EE  EE  E
Sbjct: 149 VEDEEEEEEEEEEEEEE 165



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 30/83 (36%), Positives = 41/83 (49%), Gaps = 15/83 (18%)

Query: 197 DSADAEE-DDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEAD-----------D 244
           DS+  +E DDSD   G  D D  +  E +      +E   E EE+E             D
Sbjct: 83  DSSSVDECDDSD---GTEDMDEKEEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEEED 139

Query: 245 DEDDEDGDEVEEEAEEPYEEATE 267
           ++DDEDG++VE+E EE  EE  E
Sbjct: 140 EDDDEDGEDVEDEEEEEEEEEEE 162



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 30/116 (25%), Positives = 49/116 (42%), Gaps = 26/116 (22%)

Query: 191 EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEE--------- 241
           EE D  +  + EE+D D      D D  D  +++  E  EEEE  E E E+         
Sbjct: 125 EEGDREEEEEIEEEDED-----DDEDGEDVEDEEEEEEEEEEEEEEEENEDHQMNCHNTR 179

Query: 242 --ADDDEDDEDGDEVEEEAE----------EPYEEATERTTSIATTTTTTTESVEE 285
              D ++DD + DE +   E          +  E+A  R  + +   + T+ S+E+
Sbjct: 180 IMQDTEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEMNSNTSNSLED 235


>gi|55956788 nucleolin [Homo sapiens]
          Length = 710

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 44/125 (35%), Positives = 60/125 (48%), Gaps = 19/125 (15%)

Query: 188 PLAEESDNVDSADAEEDD----SDVWWGGADTDYADGSE-DKVVEV------AEEEEVAE 236
           P +E+ D+ D  D E+DD     D      +T  A G +  KVV V       +E+E  +
Sbjct: 182 PASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEED 241

Query: 237 VEEEEADDDEDDEDGD------EVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR-- 288
            E+E+ DDDEDDED D      E EEE EEP +EA  +            E+ ++ V   
Sbjct: 242 DEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGT 301

Query: 289 VPTTA 293
            PTTA
Sbjct: 302 EPTTA 306



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 51/188 (27%), Positives = 77/188 (40%), Gaps = 30/188 (15%)

Query: 191 EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDED 250
           E+SD  +  D+EED+ D      D D  + +  K    A   E  + E++E D+D+DD++
Sbjct: 143 EDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDE 202

Query: 251 GDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDE 310
            D+ EEEA E                TT  +  +    VP  A +  +  D   E   DE
Sbjct: 203 EDDSEEEAME----------------TTPAKGKKAAKVVPVKAKNVAEDED---EEEDDE 243

Query: 311 NEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLP------KADKKAVIQHFQEKV 364
           +E     +  E  + +  E       E EE E   K  P       A +KA  +  ++KV
Sbjct: 244 DEDDDDDEDDEDDDDEDDEE-----EEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKV 298

Query: 365 ESLEQEAA 372
           E  E   A
Sbjct: 299 EGTEPTTA 306



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 39/167 (23%), Positives = 73/167 (43%), Gaps = 13/167 (7%)

Query: 190 AEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDE 249
           ++E ++ DS + EEDD D      + +  D  E   ++ A     +E E++E D+D++D+
Sbjct: 145 SDEEEDDDSEEDEEDDED------EDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDD 198

Query: 250 DGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGD 309
           D DE ++  EE  E    +    A       ++V E            D  D+  E   D
Sbjct: 199 DDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDD 258

Query: 310 ENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAV 356
           E++       +E  E +  E + +   + ++   + K  P+A K+ V
Sbjct: 259 EDD-------EEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKV 298



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 24/97 (24%), Positives = 37/97 (38%), Gaps = 8/97 (8%)

Query: 220 GSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV--------EEEAEEPYEEATERTTS 271
           G   K+    +E E    +EE ++D+EDD  G+EV        +  A    +     T  
Sbjct: 12  GDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKK 71

Query: 272 IATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPG 308
           +A  T     +V    +   T A       K + TPG
Sbjct: 72  VAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPG 108


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 39/150 (26%), Positives = 67/150 (44%), Gaps = 10/150 (6%)

Query: 188 PLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDED 247
           P  E  +  D+ DA  DD +      +T+  +G++   V +  +E   E EEEE +++ED
Sbjct: 488 PPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNK---VHIEVKENPEEEEEEEEEEEED 544

Query: 248 DEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETP 307
           +E  +E EEE E    E  E    +    +   +S + + + P+   S+    D   +  
Sbjct: 545 EESEEEEEEEGESEGSEGDEEDEKV----SDEKDSGKTLDKKPSKEMSSDSEYDSDDDRT 600

Query: 308 GDENEHAHFQKAKERLEAKHRERMSQVMRE 337
            +E     + KAK R+E +  E    V  E
Sbjct: 601 KEERA---YDKAKRRIEKRRLEHSKNVNTE 627



 Score = 33.9 bits (76), Expect = 0.52
 Identities = 32/130 (24%), Positives = 59/130 (45%), Gaps = 8/130 (6%)

Query: 228 VAEEEEVAEVEEEEADDDEDDEDG-DEVEEEAEEPYEEATERTTSIATTTTTTTESVEEV 286
           +   EE AE      DD+E D+   D+ +++ E+  +E  ++      T     E++ ++
Sbjct: 292 IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKL 351

Query: 287 VRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEE-AERQA 345
                      +   K LE      E    +K +ERLE + RER  Q  +E +E  +++ 
Sbjct: 352 KEEEERQKREEEERIKRLE------ELEAKRKEEERLEQEKRERKKQKEKERKERLKKEG 405

Query: 346 KNLPKADKKA 355
           K L K+ ++A
Sbjct: 406 KLLTKSQREA 415



 Score = 31.2 bits (69), Expect = 3.4
 Identities = 30/148 (20%), Positives = 58/148 (39%), Gaps = 8/148 (5%)

Query: 219 DGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTT 278
           DGSE       E+E+ ++  +E +  +   E GDE +E  +    +   +         +
Sbjct: 162 DGSE-------EDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIES 214

Query: 279 TTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREW 338
             E  +   ++ T A    +  ++  +   +E       K KE LE   +++  Q   + 
Sbjct: 215 GNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQR 274

Query: 339 EEAERQAKNLPKADKKAVIQHFQEKVES 366
           +  E   K+    D   VI   +EK E+
Sbjct: 275 KFEEETVKSKVTVD-TGVIPASEEKAET 301


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 37/134 (27%), Positives = 58/134 (43%), Gaps = 17/134 (12%)

Query: 212  GADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEE-PYEEATERTT 270
            G + D  +   ++     EEEE  E EEEE DDD+D +D DE E + E+    EA+E+  
Sbjct: 1032 GGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDE 1091

Query: 271  SIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRER 330
                         EE V + T+ A    +         + +E + F+ + E   +   + 
Sbjct: 1092 G--------DSDEEETVSIVTSKAEATSS--------SESSESSEFESSSESSPSSSEDE 1135

Query: 331  MSQVMREWEEAERQ 344
               V RE EE E +
Sbjct: 1136 EEVVAREEEEEEEE 1149



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 41/180 (22%), Positives = 72/180 (40%), Gaps = 27/180 (15%)

Query: 191  EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDED 250
            EE +  +  + EEDD D           D S+D+     ++E+ A  E  E D      +
Sbjct: 1049 EEEEEAEEEEEEEDDDD-----------DDSDDRDESENDDEDTALSEASEKD------E 1091

Query: 251  GDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDE 310
            GD  EEE         E T+S  ++ ++  ES  E      ++ S+ +  ++ +    +E
Sbjct: 1092 GDSDEEETVSIVTSKAEATSSSESSESSEFESSSE------SSPSSSEDEEEVVAREEEE 1145

Query: 311  NEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQE 370
             E      A+E + +   E   Q   + EEA   A   P  D   + +    + E++  E
Sbjct: 1146 EEEEEEMVAEESMASAGPEDFEQ---DGEEA-ALAPGAPAVDSLGMEEEVDIETEAVAPE 1201



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 27/117 (23%), Positives = 50/117 (42%), Gaps = 3/117 (2%)

Query: 191  EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDED 250
            EE+ ++ ++ AE   S        +++   SE       +EEEV   EEEE +++E+   
Sbjct: 1097 EETVSIVTSKAEATSSSE--SSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVA 1154

Query: 251  GDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETP 307
             + +     E +E+  E            +  +EE V + T A + P+     L+ P
Sbjct: 1155 EESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVA-PEERPSMLDEP 1210



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 46/187 (24%), Positives = 71/187 (37%), Gaps = 19/187 (10%)

Query: 193  SDNVDSADAE---EDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDE 249
            S +VD  D E   E D D+    ADT       D    V      A   E ++  +ED++
Sbjct: 984  STSVDEEDEESERERDRDM----ADTPCELAKRDPK-GVGVRRRPARPLELDSGGEEDEK 1038

Query: 250  DGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGD 309
            +    E+E+ E  EEA E           + +  E       TA S     D+     GD
Sbjct: 1039 ESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDE-----GD 1093

Query: 310  ENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKA--DKKAVIQHFQEKVESL 367
             +E         + EA      S    E  E E  +++ P +  D++ V+   +E+ E  
Sbjct: 1094 SDEEETVSIVTSKAEATSSSESS----ESSEFESSSESSPSSSEDEEEVVAREEEEEEEE 1149

Query: 368  EQEAANE 374
            E+  A E
Sbjct: 1150 EEMVAEE 1156


>gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens]
          Length = 295

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 69/292 (23%), Positives = 121/292 (41%), Gaps = 25/292 (8%)

Query: 223 DKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTES 282
           ++VVE  EEEE  E   EE +D  +DE  DE EE AEE  E   E   + A       E+
Sbjct: 5   EEVVEEYEEEEQEEAAVEEEEDWREDE--DEQEEAAEEDAEAEAETEETRAEEDEEEEEA 62

Query: 283 VEEVVRVPTTAASTPDAVDKYLETPG-DENEHAHFQKAKERLEAKHRERMSQVMREWEE- 340
            E        +   P +    L  P   + E   F          HR+RM + + E +  
Sbjct: 63  KEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDI-------HRKRMEKDLNELQAL 115

Query: 341 AERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALEN 400
            E   +N  K +++ V    ++++E    E A +++   E    R   +  +R R   E 
Sbjct: 116 IEAHFENRKKEEEELV--SLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEE 173

Query: 401 YITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMT--H 458
                +    + + + NM+      ++ +R+   +  E  +    KK    R +V+   H
Sbjct: 174 NRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREK---KKKILAERRKVLAIDH 230

Query: 459 LR--VIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISE 508
           L    + E+  +    +YN+ A   ++Q++      K+Q Y  +VL N I++
Sbjct: 231 LNEDQLREKAKELWQSIYNLEAEKFDLQEKF-----KQQKYEINVLRNRIND 277


>gi|61097912 nucleolar protein with MIF4G domain 1 [Homo sapiens]
          Length = 860

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 56/233 (24%), Positives = 95/233 (40%), Gaps = 32/233 (13%)

Query: 181 GVEFVCCPL--AEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVE 238
           G++++   L   + S   DS+  EE+D+      +D +     E +  E  + E+  + +
Sbjct: 215 GLDYILGALESGKNSGLYDSSGEEEEDAGQTLPESDLESDSQDESEEEEEGDVEKEKKAQ 274

Query: 239 EEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPD 298
           E EA  ++DDED +  EE+ EE  + A E+            E  E        ++   D
Sbjct: 275 EAEAQSEDDDEDTE--EEQGEEKEKGAQEKRRGKRVRFAEDEEKSE-------NSSEDGD 325

Query: 299 AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQ 358
             DK L   G++    H ++A+E ++ K +          EE ER  K++     K ++ 
Sbjct: 326 ITDKSLCGSGEKYIPPHVRQAEETVDFKKK----------EELERLKKHV-----KGLLN 370

Query: 359 HFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPR 411
                    E   A+   QL E +MA     +ND    AL        A+P R
Sbjct: 371 RLS------EPNMASISGQLEELYMAHSRKDMNDTLTSALMGACVTASAMPSR 417


>gi|87299628 biorientation of chromosomes in cell division 1-like
           [Homo sapiens]
          Length = 3051

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 70/329 (21%), Positives = 129/329 (39%), Gaps = 25/329 (7%)

Query: 178 KFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEV 237
           K + VE +  P  + S+   + +  ++D  +     D+D  DG  D  V      +++  
Sbjct: 365 KEKEVESLKLPSEKNSNKAKTVEGTKEDFSL----IDSD-VDGLTDITVSSVHTSDLSSF 419

Query: 238 EEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTP 297
           EE   D +E+    D +EE      +E   +     T T+ ++E   + VR        P
Sbjct: 420 EE---DTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVR--HAYVHKP 474

Query: 298 DAVDKYLETPGDE-----NEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKAD 352
               KY     DE        +  ++ +ERL  +   R     +  ++AE+   +  K  
Sbjct: 475 YLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQ 534

Query: 353 KKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRP 412
            ++ +   +   +SLE +AA  ++ L E  +   +  L+ +R+    N     +      
Sbjct: 535 GRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYE 594

Query: 413 RHVFNMLKKYVRAEQKDRQHTLKHFEHVR-MVDPKKAAQIRSQVMTHLRVIYERMNQSL- 470
                 LK     E K++  + K  +HV    +P K A+  S+    L V+ E  N+S  
Sbjct: 595 EDSKETLKTSEHCE-KEKISSSKELKHVHAKSEPSKPARRLSE---SLHVVDENKNESKL 650

Query: 471 ----SLLYNVPAVAEEIQDEVDELLQKEQ 495
                   + P + E +Q+E D    K Q
Sbjct: 651 EREHKRRTSTPVIMEGVQEETDTRDVKRQ 679



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 33/171 (19%), Positives = 69/171 (40%), Gaps = 25/171 (14%)

Query: 220  GSEDKVVEV-----AEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIAT 274
            G + KVVE      A ++      ++E + +E+D +     +  ++P+EE     T +  
Sbjct: 918  GKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEE-----TGVEP 972

Query: 275  TTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQV 334
               T + S     +  +  A  P A +KY       ++ +   + + +L   H+ R    
Sbjct: 973  VLETASSSAHSTQKDSSHRAKLPLAKEKY-----KSDKDSTSTRLERKLSDGHKSR---- 1023

Query: 335  MREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMAR 385
                   +  +K++ K D+        ++V+S   E A     L+E  ++R
Sbjct: 1024 -----SLKHSSKDIKKKDENKSDDKDGKEVDS-SHEKARGNSSLMEKKLSR 1068



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 29/101 (28%), Positives = 43/101 (42%), Gaps = 9/101 (8%)

Query: 221  SEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTT 280
            S+D      E +    V +   D  E + D +E EEE +EP   AT R+T+ +    + T
Sbjct: 2958 SDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEP-SGATTRSTTRSEAQRSKT 3016

Query: 281  ESVEEVVRVPTTAASTPDAVDKYLETPGDEN-EHAHFQKAK 320
            +    + R      S P A      T G +  E A  +KAK
Sbjct: 3017 QLSPSIKR--KREVSPPGA-----RTRGQQRVEEAPVKKAK 3050



 Score = 29.6 bits (65), Expect = 9.8
 Identities = 18/57 (31%), Positives = 30/57 (52%), Gaps = 1/57 (1%)

Query: 228  VAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE 284
            V+++ E +E E +      D  + D+ E+E++E  EE  E   S ATT +TT    +
Sbjct: 2957 VSDDAESSEPERKRQKSVSDPVE-DKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQ 3012


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
           sapiens]
          Length = 1251

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 43/166 (25%), Positives = 71/166 (42%), Gaps = 6/166 (3%)

Query: 210 WGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERT 269
           W  A  D +   +   V  A EEE   VE+   +    +E+ ++ EEE EE  EE  E  
Sbjct: 313 WEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEEEEEEEEEEEEEV 372

Query: 270 TSIATTTTTTTE-SVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHR 328
           T +   +   ++  V +     T   ST D   K  E  G+E +    +KAKE  E    
Sbjct: 373 TEVLLDSCVVSQVGVGQSEEDGTRPQSTSD--QKLWEEVGEEAKKEAEEKAKEEAEEVAE 430

Query: 329 ERMSQVMREWEEAERQAKNLPKADKK---AVIQHFQEKVESLEQEA 371
           E   +  ++W E + + +   +A      A  QH + +VE  + ++
Sbjct: 431 EEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADS 476


>gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens]
          Length = 282

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 67/293 (22%), Positives = 122/293 (41%), Gaps = 40/293 (13%)

Query: 223 DKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTES 282
           ++VVE  EEEE  E EE   +D E + + +E   E +E  EEA E               
Sbjct: 5   EEVVEEYEEEEQEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDG----------P 54

Query: 283 VEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEE-A 341
           +EE    P   +  P+ V   +     + E   F          HR+RM + + E +   
Sbjct: 55  MEE--SKPKPRSFMPNLVPPKI----PDGERVDFDDI-------HRKRMEKDLNELQALI 101

Query: 342 ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENY 401
           E   +N  K +++ V    ++++E    E A +++   E    R   +  +R R   E  
Sbjct: 102 EAHFENRKKEEEELV--SLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEEN 159

Query: 402 ITALQAVPPRPRHVFNMLK--KYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMT-- 457
               +    + + + NM+    Y++  Q +R+   +  E  +    KK    R +V+   
Sbjct: 160 RRKAEDEARKKKALSNMMHFGGYIQKAQTERKSGKRQTEREK---KKKILAERRKVLAID 216

Query: 458 HLR--VIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISE 508
           HL    + E+  +    +YN+ A   ++Q++      K+Q Y  +VL N I++
Sbjct: 217 HLNEDQLREKAKELWQSIYNLEAEKFDLQEKF-----KQQKYEINVLRNRIND 264


>gi|4757900 calreticulin precursor [Homo sapiens]
          Length = 417

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 29/73 (39%), Positives = 40/73 (54%), Gaps = 2/73 (2%)

Query: 197 DSADAEEDDSDVWW--GGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 254
           D A AEE  ++ W     A+    D  +++     EEE+    EEEEA+D EDDED DE 
Sbjct: 335 DEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDED 394

Query: 255 EEEAEEPYEEATE 267
           EE+ E+  E+  E
Sbjct: 395 EEDEEDKEEDEEE 407


>gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member B [Homo sapiens]
          Length = 251

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 41/103 (39%), Positives = 47/103 (45%), Gaps = 18/103 (17%)

Query: 163 TNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSE 222
           TNL+DY           R   F   P     D  D  D E  DSD    G D +  D  E
Sbjct: 126 TNLNDY-----------RESVFKLLPQLTYLDGYDREDQEAPDSDAEVDGVDEEEED--E 172

Query: 223 DKVVEVAEEEEVAEVEE--EEADDDED---DEDGDEVEEEAEE 260
           +   E  E++E  E EE  EE D+DED   DED DEV EE EE
Sbjct: 173 EGEDEEDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEEE 215



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 31/81 (38%), Positives = 43/81 (53%), Gaps = 5/81 (6%)

Query: 191 EESDNVDSADAEEDDSDVWWGGADTDY-ADGSEDKVVEVAEEEEVAEVEEEEADDDEDDE 249
           EE D     + +EDD D    G + ++  +  ED+ VE  E+++    EEEE   DE+DE
Sbjct: 168 EEEDEEGEDEEDEDDED----GEEEEFDEEDDEDEDVEGDEDDDEVSEEEEEFGLDEEDE 223

Query: 250 DGDEVEEEAEEPYEEATERTT 270
           D DE EEE E    E  +R T
Sbjct: 224 DEDEDEEEEEGGKGEKRKRET 244



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 23/77 (29%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 191 EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDED 250
           E+ D+ D  + E D+ D      D D     +D  V   EEE   + E+E+ D+DE++E+
Sbjct: 178 EDEDDEDGEEEEFDEED----DEDEDVEGDEDDDEVSEEEEEFGLDEEDEDEDEDEEEEE 233

Query: 251 GDEVEEEAEEPYEEATE 267
           G + E+   E  +E  +
Sbjct: 234 GGKGEKRKRETDDEGED 250



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 23/58 (39%), Positives = 33/58 (56%), Gaps = 7/58 (12%)

Query: 217 YADGSEDKVVEVAEEE-EVAEVEEEEADD------DEDDEDGDEVEEEAEEPYEEATE 267
           Y DG + +  E  + + EV  V+EEE D+      DEDDEDG+E E + E+  +E  E
Sbjct: 144 YLDGYDREDQEAPDSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDEDEDVE 201


>gi|38569484 kinesin family member 21A [Homo sapiens]
          Length = 1661

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 68/317 (21%), Positives = 127/317 (40%), Gaps = 42/317 (13%)

Query: 191 EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA--EVEEEEADDDEDD 248
           +E     S   +ED++D      +       E+  +EV E +EV+  E EEEE +++EDD
Sbjct: 551 KEKRKKKSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEEEEEEEEDD 610

Query: 249 EDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPG 308
            DG E  +E++   +E       +A  T                 A     +D+      
Sbjct: 611 IDGGESSDESDSESDEKANYQADLANIT--------------CEIAIKQKLIDEL----- 651

Query: 309 DENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLE 368
            EN     Q  K++ E K      ++     E ++  +NL      +V  + +EK + + 
Sbjct: 652 -ENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNL-----GSVESYSEEKAKKVR 705

Query: 369 QEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQK 428
            E   ++ Q +   + R++A   +  RL L+N     + +    + V  M K  VR  ++
Sbjct: 706 SE-YEKKLQAMNKELQRLQAAQKEHARL-LKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQ 763

Query: 429 DRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLL----YNVPAVAEEIQ 484
            ++      E  R+ + +     R++ +  L+    + +  L LL     N   V     
Sbjct: 764 MKEEQ----EKARLTESR-----RNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKT 814

Query: 485 DEVDELLQKEQNYSDDV 501
           +EV  L ++ +  SD V
Sbjct: 815 EEVTALRRQVRPMSDKV 831


>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
          Length = 543

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 29/75 (38%), Positives = 42/75 (56%), Gaps = 1/75 (1%)

Query: 191 EESDNVDSADAEE-DDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDE 249
           E  + +++A AEE  D     G A+ +  D  E +  E AEEEE A+ E EEA ++E+  
Sbjct: 453 EVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGG 512

Query: 250 DGDEVEEEAEEPYEE 264
           +G+E EE  E   EE
Sbjct: 513 EGEEGEETKEAEEEE 527



 Score = 34.7 bits (78), Expect = 0.31
 Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 8/71 (11%)

Query: 223 DKVVEVAEEEEV-------AEVEEEEADDDE-DDEDGDEVEEEAEEPYEEATERTTSIAT 274
           ++ +E A+ EE         E EEEE D +E ++E+  E EE A+E  EEA E       
Sbjct: 455 EETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEG 514

Query: 275 TTTTTTESVEE 285
                T+  EE
Sbjct: 515 EEGEETKEAEE 525



 Score = 33.1 bits (74), Expect = 0.89
 Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 6/63 (9%)

Query: 217 YADGSEDKVVEVAEEEEVAEVEE------EEADDDEDDEDGDEVEEEAEEPYEEATERTT 270
           Y    +++ +EV E  E A+ EE       E + +E+++D +E EEE     EEA +  +
Sbjct: 443 YTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEES 502

Query: 271 SIA 273
             A
Sbjct: 503 EEA 505



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 24/78 (30%), Positives = 40/78 (51%), Gaps = 5/78 (6%)

Query: 190 AEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDE 249
           AEE+ +   ++ E ++ +     A+ + A   E+   E +EE +    EEEE  + E+ E
Sbjct: 463 AEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAK----EEEEGGEGEEGE 518

Query: 250 DGDEVEEEAEEPYEEATE 267
           +  E EEE E+  E A E
Sbjct: 519 ETKEAEEE-EKKVEGAGE 535


>gi|239756368 PREDICTED: similar to acidic (leucine-rich) nuclear
           phosphoprotein 32 family, member B [Homo sapiens]
          Length = 272

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 37/93 (39%), Positives = 48/93 (51%), Gaps = 13/93 (13%)

Query: 190 AEESD-NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEE----------EEVAEVE 238
           A +SD  VD  D EE+D +      D +  DG E+++ E  +E          +EV+E E
Sbjct: 175 APDSDAQVDGVDKEEEDEE-GEDEKDXENEDGEEEELDEEEDEDEDVEGDDDKDEVSEEE 233

Query: 239 EE-EADDDEDDEDGDEVEEEAEEPYEEATERTT 270
           EE   D DEDDED DE EEE E    E  +R T
Sbjct: 234 EEFGLDKDEDDEDEDEDEEEEESGKGENRKRET 266



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 30/70 (42%), Positives = 37/70 (52%), Gaps = 3/70 (4%)

Query: 194 DNVDSADAEEDDSDVWWGGADTDYAD--GSEDKVVEVAEEEEVAEVEEEEADDD-EDDED 250
           D  D  D E  DSD    G D +  D  G ++K  E  + EE    EEE+ D+D E D+D
Sbjct: 166 DTYDPEDQEAPDSDAQVDGVDKEEEDEEGEDEKDXENEDGEEEELDEEEDEDEDVEGDDD 225

Query: 251 GDEVEEEAEE 260
            DEV EE EE
Sbjct: 226 KDEVSEEEEE 235



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 22/77 (28%), Positives = 41/77 (53%), Gaps = 3/77 (3%)

Query: 191 EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDED 250
           E+  + ++ D EE++ D      D D     +D   EV+EEEE   ++++E D+DED+++
Sbjct: 195 EDEKDXENEDGEEEELDE---EEDEDEDVEGDDDKDEVSEEEEEFGLDKDEDDEDEDEDE 251

Query: 251 GDEVEEEAEEPYEEATE 267
            +E   + E    E  +
Sbjct: 252 EEEESGKGENRKRETDD 268



 Score = 30.0 bits (66), Expect = 7.5
 Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 8/67 (11%)

Query: 189 LAEESDNVDSADAEEDDSDVWWG----GADTDYADGSEDKVVEVAEEEEVAEVEEEEADD 244
           L EE D  +  + ++D  +V       G D D  D  ED   E  EEEE  + E  + + 
Sbjct: 210 LDEEEDEDEDVEGDDDKDEVSEEEEEFGLDKDEDDEDED---EDEEEEESGKGENRKRET 266

Query: 245 DEDDEDG 251
           D D+EDG
Sbjct: 267 D-DEEDG 272


>gi|239750893 PREDICTED: similar to acidic (leucine-rich) nuclear
           phosphoprotein 32 family, member B [Homo sapiens]
          Length = 272

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 37/93 (39%), Positives = 48/93 (51%), Gaps = 13/93 (13%)

Query: 190 AEESD-NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEE----------EEVAEVE 238
           A +SD  VD  D EE+D +      D +  DG E+++ E  +E          +EV+E E
Sbjct: 175 APDSDAQVDGVDKEEEDEE-GEDEKDXENEDGEEEELDEEEDEDEDVEGDDDKDEVSEEE 233

Query: 239 EE-EADDDEDDEDGDEVEEEAEEPYEEATERTT 270
           EE   D DEDDED DE EEE E    E  +R T
Sbjct: 234 EEFGLDKDEDDEDEDEDEEEEESGKGENRKRET 266



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 30/70 (42%), Positives = 37/70 (52%), Gaps = 3/70 (4%)

Query: 194 DNVDSADAEEDDSDVWWGGADTDYAD--GSEDKVVEVAEEEEVAEVEEEEADDD-EDDED 250
           D  D  D E  DSD    G D +  D  G ++K  E  + EE    EEE+ D+D E D+D
Sbjct: 166 DTYDPEDQEAPDSDAQVDGVDKEEEDEEGEDEKDXENEDGEEEELDEEEDEDEDVEGDDD 225

Query: 251 GDEVEEEAEE 260
            DEV EE EE
Sbjct: 226 KDEVSEEEEE 235



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 22/77 (28%), Positives = 41/77 (53%), Gaps = 3/77 (3%)

Query: 191 EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDED 250
           E+  + ++ D EE++ D      D D     +D   EV+EEEE   ++++E D+DED+++
Sbjct: 195 EDEKDXENEDGEEEELDE---EEDEDEDVEGDDDKDEVSEEEEEFGLDKDEDDEDEDEDE 251

Query: 251 GDEVEEEAEEPYEEATE 267
            +E   + E    E  +
Sbjct: 252 EEEESGKGENRKRETDD 268



 Score = 30.0 bits (66), Expect = 7.5
 Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 8/67 (11%)

Query: 189 LAEESDNVDSADAEEDDSDVWWG----GADTDYADGSEDKVVEVAEEEEVAEVEEEEADD 244
           L EE D  +  + ++D  +V       G D D  D  ED   E  EEEE  + E  + + 
Sbjct: 210 LDEEEDEDEDVEGDDDKDEVSEEEEEFGLDKDEDDEDED---EDEEEEESGKGENRKRET 266

Query: 245 DEDDEDG 251
           D D+EDG
Sbjct: 267 D-DEEDG 272


>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
          Length = 709

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 30/74 (40%), Positives = 40/74 (54%), Gaps = 3/74 (4%)

Query: 197 DSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDED---DEDGDE 253
           +  ++EE  SD   G + +    G+  +  E   EE+V E EE E D +ED   DEDG+E
Sbjct: 172 EEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEE 231

Query: 254 VEEEAEEPYEEATE 267
            EEE EE  EE  E
Sbjct: 232 EEEEEEEEEEEEEE 245



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 27/76 (35%), Positives = 40/76 (52%), Gaps = 4/76 (5%)

Query: 193 SDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGD 252
           SD+   +    D+     G    +  +G E+ V E  E EE AE +EE  +D E++E+ +
Sbjct: 181 SDHETGSSGSSDEQ----GNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEE 236

Query: 253 EVEEEAEEPYEEATER 268
           E EEE EE  EE  E+
Sbjct: 237 EEEEEEEEEEEEEYEQ 252



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 26/97 (26%), Positives = 52/97 (53%), Gaps = 4/97 (4%)

Query: 192 ESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEV--EEEEADDDEDDE 249
           E+ +  S+D + ++++    G + D  +  +++V E AEE+E  +   EEEE +++E++E
Sbjct: 184 ETGSSGSSDEQGNNTENEEEGVEEDVEE--DEEVEEDAEEDEEVDEDGEEEEEEEEEEEE 241

Query: 250 DGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEV 286
           + +E EEE E+   +  E      T +  +    E V
Sbjct: 242 EEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESV 278



 Score = 37.4 bits (85), Expect = 0.047
 Identities = 26/95 (27%), Positives = 49/95 (51%), Gaps = 1/95 (1%)

Query: 190 AEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDE 249
           ++E  N    + E  + DV       + A+  E+   +  EEEE  E EEEE +++E++ 
Sbjct: 191 SDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEY 250

Query: 250 DGDEVEEEAE-EPYEEATERTTSIATTTTTTTESV 283
           + DE +++ E   Y+  +E + S + + + T  SV
Sbjct: 251 EQDERDQKEEGNDYDTRSEASDSGSESVSFTDGSV 285


>gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]
          Length = 727

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 30/74 (40%), Positives = 40/74 (54%), Gaps = 3/74 (4%)

Query: 197 DSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDED---DEDGDE 253
           +  ++EE  SD   G + +    G+  +  E   EE+V E EE E D +ED   DEDG+E
Sbjct: 172 EEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEE 231

Query: 254 VEEEAEEPYEEATE 267
            EEE EE  EE  E
Sbjct: 232 EEEEEEEEEEEEEE 245



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 27/76 (35%), Positives = 40/76 (52%), Gaps = 4/76 (5%)

Query: 193 SDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGD 252
           SD+   +    D+     G    +  +G E+ V E  E EE AE +EE  +D E++E+ +
Sbjct: 181 SDHETGSSGSSDEQ----GNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEE 236

Query: 253 EVEEEAEEPYEEATER 268
           E EEE EE  EE  E+
Sbjct: 237 EEEEEEEEEEEEEYEQ 252



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 26/97 (26%), Positives = 52/97 (53%), Gaps = 4/97 (4%)

Query: 192 ESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEV--EEEEADDDEDDE 249
           E+ +  S+D + ++++    G + D  +  +++V E AEE+E  +   EEEE +++E++E
Sbjct: 184 ETGSSGSSDEQGNNTENEEEGVEEDVEE--DEEVEEDAEEDEEVDEDGEEEEEEEEEEEE 241

Query: 250 DGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEV 286
           + +E EEE E+   +  E      T +  +    E V
Sbjct: 242 EEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESV 278



 Score = 37.4 bits (85), Expect = 0.047
 Identities = 26/95 (27%), Positives = 49/95 (51%), Gaps = 1/95 (1%)

Query: 190 AEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDE 249
           ++E  N    + E  + DV       + A+  E+   +  EEEE  E EEEE +++E++ 
Sbjct: 191 SDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEY 250

Query: 250 DGDEVEEEAE-EPYEEATERTTSIATTTTTTTESV 283
           + DE +++ E   Y+  +E + S + + + T  SV
Sbjct: 251 EQDERDQKEEGNDYDTRSEASDSGSESVSFTDGSV 285


>gi|115529449 upstream binding transcription factor, RNA polymerase
           I isoform b [Homo sapiens]
          Length = 727

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 23/67 (34%), Positives = 39/67 (58%), Gaps = 3/67 (4%)

Query: 191 EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDED 250
           E+ D+ D  + EEDD +   G +  D  D SE    + +E+ +  E ++E+ DDDEDD++
Sbjct: 646 EDEDDEDEDEEEEDDEN---GDSSEDGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDE 702

Query: 251 GDEVEEE 257
            ++ E E
Sbjct: 703 DEDNESE 709



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 24/82 (29%), Positives = 41/82 (50%), Gaps = 5/82 (6%)

Query: 190 AEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDE 249
           +EE D  D  D +ED+ +      D +  D SED         E    + +E ++D++DE
Sbjct: 640 SEEDDEEDEDDEDEDEEE-----EDDENGDSSEDGGDSSESSSEDESEDGDENEEDDEDE 694

Query: 250 DGDEVEEEAEEPYEEATERTTS 271
           D DE ++E E+   E +  ++S
Sbjct: 695 DDDEDDDEDEDNESEGSSSSSS 716



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 16/44 (36%), Positives = 28/44 (63%), Gaps = 3/44 (6%)

Query: 227 EVAEEEEVAEVEEEEADDDEDDEDGDEVE---EEAEEPYEEATE 267
           E  E++E  E +E+E +++EDDE+GD  E   + +E   E+ +E
Sbjct: 639 ESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESE 682



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 18/51 (35%), Positives = 29/51 (56%), Gaps = 4/51 (7%)

Query: 221 SEDKVVEVAEEEEVAEVEEEEADDDED----DEDGDEVEEEAEEPYEEATE 267
           S+ +  E  EE+E  E E+EE +DDE+    ++ GD  E  +E+  E+  E
Sbjct: 636 SKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDE 686



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 13/48 (27%), Positives = 28/48 (58%)

Query: 238 EEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEE 285
           E++E D+D++DED +E ++E  +  E+  + + S +   +   +  EE
Sbjct: 642 EDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEE 689



 Score = 30.0 bits (66), Expect = 7.5
 Identities = 12/42 (28%), Positives = 27/42 (64%)

Query: 229 AEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT 270
           ++ E   + EE+E D+DED+E+ D+   ++ E   +++E ++
Sbjct: 636 SKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSS 677


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,509,822
Number of Sequences: 37866
Number of extensions: 1243790
Number of successful extensions: 21188
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 492
Number of HSP's successfully gapped in prelim test: 646
Number of HSP's that attempted gapping in prelim test: 8696
Number of HSP's gapped (non-prelim): 6111
length of query: 695
length of database: 18,247,518
effective HSP length: 109
effective length of query: 586
effective length of database: 14,120,124
effective search space: 8274392664
effective search space used: 8274392664
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.