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Search of human proteins with 41406055
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41406055 amyloid beta A4 protein isoform b precursor [Homo
sapiens]
(751 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sa... 1531 0.0
gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sap... 1519 0.0
gi|209915573 amyloid beta A4 protein isoform f precursor [Homo s... 1366 0.0
gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sa... 1340 0.0
gi|209915570 amyloid beta A4 protein isoform e precursor [Homo s... 1187 0.0
gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform ... 757 0.0
gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 ... 755 0.0
gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform ... 641 0.0
gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform ... 383 e-106
gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor... 359 5e-99
gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor ... 356 5e-98
gi|10863909 serine protease inhibitor, Kunitz type, 2 [Homo sapi... 72 2e-12
gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo s... 67 8e-11
gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo s... 67 8e-11
gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo ... 67 8e-11
gi|189571689 serine protease inhibitor, Kunitz type, 3 [Homo sap... 67 8e-11
gi|32313599 serine peptidase inhibitor, Kunitz type 1 isoform 1 ... 64 4e-10
gi|74027265 serine peptidase inhibitor, Kunitz type 1 isoform 2 ... 63 9e-10
gi|4504329 serine peptidase inhibitor, Kunitz type 1 isoform 2 p... 63 9e-10
gi|154759255 collagen, type XXVIII precursor [Homo sapiens] 63 9e-10
gi|31563528 serine peptidase inhibitor-like, with Kunitz and WAP... 62 1e-09
gi|10732863 serine peptidase inhibitor-like, with Kunitz and WAP... 62 1e-09
gi|145309328 papilin [Homo sapiens] 62 3e-09
gi|4502067 alpha-1-microglobulin/bikunin preproprotein [Homo sap... 61 3e-09
gi|73760409 tissue factor pathway inhibitor isoform b precursor ... 61 4e-09
gi|5454114 tissue factor pathway inhibitor isoform a precursor [... 61 4e-09
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens] 60 1e-08
gi|5730091 tissue factor pathway inhibitor 2 [Homo sapiens] 59 2e-08
gi|28212222 WFIKKN2 protein [Homo sapiens] 59 2e-08
gi|60498973 myelin transcription factor 1-like [Homo sapiens] 57 6e-08
>gi|41406055 amyloid beta A4 protein isoform b precursor [Homo
sapiens]
Length = 751
Score = 1531 bits (3965), Expect = 0.0
Identities = 751/751 (100%), Positives = 751/751 (100%)
Query: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
Sbjct: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
Query: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
Sbjct: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
Query: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Sbjct: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
Query: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Sbjct: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
Query: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC 300
EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
Sbjct: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC 300
Query: 301 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYL 360
RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYL
Sbjct: 301 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYL 360
Query: 361 ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKV 420
ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKV
Sbjct: 361 ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKV 420
Query: 421 ESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVR 480
ESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVR
Sbjct: 421 ESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVR 480
Query: 481 AEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ 540
AEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ
Sbjct: 481 AEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ 540
Query: 541 DEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQ 600
DEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQ
Sbjct: 541 DEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQ 600
Query: 601 PWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDS 660
PWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDS
Sbjct: 601 PWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDS 660
Query: 661 GYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVD 720
GYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVD
Sbjct: 661 GYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVD 720
Query: 721 AAVTPEERHLSKMQQNGYENPTYKFFEQMQN 751
AAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 721 AAVTPEERHLSKMQQNGYENPTYKFFEQMQN 751
>gi|4502167 amyloid beta A4 protein isoform a precursor [Homo
sapiens]
Length = 770
Score = 1519 bits (3933), Expect = 0.0
Identities = 750/770 (97%), Positives = 751/770 (97%), Gaps = 19/770 (2%)
Query: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
Sbjct: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
Query: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
Sbjct: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
Query: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Sbjct: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
Query: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Sbjct: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
Query: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC 300
EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
Sbjct: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC 300
Query: 301 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA---------------- 344
RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
Sbjct: 301 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD 360
Query: 345 ---IPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA 401
+PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
Sbjct: 361 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA 420
Query: 402 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL 461
KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
Sbjct: 421 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL 480
Query: 462 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER 521
QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
Sbjct: 481 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER 540
Query: 522 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET 581
MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
Sbjct: 541 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET 600
Query: 582 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN 641
KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
Sbjct: 601 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN 660
Query: 642 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL 701
IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
Sbjct: 661 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL 720
Query: 702 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 751
VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 721 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 770
>gi|209915573 amyloid beta A4 protein isoform f precursor [Homo
sapiens]
Length = 714
Score = 1366 bits (3536), Expect = 0.0
Identities = 676/696 (97%), Positives = 677/696 (97%), Gaps = 19/696 (2%)
Query: 75 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 134
EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK
Sbjct: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78
Query: 135 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 194
FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD
Sbjct: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138
Query: 195 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 254
NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV
Sbjct: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 198
Query: 255 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG 314
EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG
Sbjct: 199 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG 258
Query: 315 KCAPFFYGGCGGNRNNFDTEEYCMAVCGSA-------------------IPTTAASTPDA 355
KCAPFFYGGCGGNRNNFDTEEYCMAVCGSA +PTTAASTPDA
Sbjct: 259 KCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDA 318
Query: 356 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 415
VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH
Sbjct: 319 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 378
Query: 416 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 475
FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML
Sbjct: 379 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 438
Query: 476 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 535
KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV
Sbjct: 439 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 498
Query: 536 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 595
AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS
Sbjct: 499 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 558
Query: 596 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 655
LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE
Sbjct: 559 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 618
Query: 656 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 715
FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG
Sbjct: 619 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 678
Query: 716 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 751
VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 679 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 714
>gi|41406057 amyloid beta A4 protein isoform c precursor [Homo
sapiens]
Length = 695
Score = 1340 bits (3469), Expect = 0.0
Identities = 676/751 (90%), Positives = 679/751 (90%), Gaps = 56/751 (7%)
Query: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
Sbjct: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
Query: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
Sbjct: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
Query: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Sbjct: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
Query: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Sbjct: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
Query: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC 300
EADDDEDDEDGDEVEEEAEEPYEEA T TT+ + E E
Sbjct: 241 EADDDEDDEDGDEVEEEAEEPYEEA--------TERTTSIATTTTTTTESVEEVVR---- 288
Query: 301 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYL 360
+PTTAASTPDAVDKYL
Sbjct: 289 --------------------------------------------VPTTAASTPDAVDKYL 304
Query: 361 ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKV 420
ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKV
Sbjct: 305 ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKV 364
Query: 421 ESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVR 480
ESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVR
Sbjct: 365 ESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVR 424
Query: 481 AEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ 540
AEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ
Sbjct: 425 AEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ 484
Query: 541 DEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQ 600
DEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQ
Sbjct: 485 DEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQ 544
Query: 601 PWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDS 660
PWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDS
Sbjct: 545 PWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDS 604
Query: 661 GYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVD 720
GYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVD
Sbjct: 605 GYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVD 664
Query: 721 AAVTPEERHLSKMQQNGYENPTYKFFEQMQN 751
AAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 665 AAVTPEERHLSKMQQNGYENPTYKFFEQMQN 695
>gi|209915570 amyloid beta A4 protein isoform e precursor [Homo
sapiens]
Length = 639
Score = 1187 bits (3072), Expect = 0.0
Identities = 602/677 (88%), Positives = 605/677 (89%), Gaps = 56/677 (8%)
Query: 75 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 134
EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK
Sbjct: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78
Query: 135 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 194
FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD
Sbjct: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138
Query: 195 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 254
NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV
Sbjct: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 198
Query: 255 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG 314
EEEAEEPYEEA T TT+ + E E
Sbjct: 199 EEEAEEPYEEA--------TERTTSIATTTTTTTESVEEVVR------------------ 232
Query: 315 KCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYLETPGDENEHAHFQK 374
+PTTAASTPDAVDKYLETPGDENEHAHFQK
Sbjct: 233 ------------------------------VPTTAASTPDAVDKYLETPGDENEHAHFQK 262
Query: 375 AKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQL 434
AKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQL
Sbjct: 263 AKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQL 322
Query: 435 VETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFE 494
VETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFE
Sbjct: 323 VETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFE 382
Query: 495 HVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYS 554
HVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYS
Sbjct: 383 HVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYS 442
Query: 555 DDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANT 614
DDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANT
Sbjct: 443 DDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANT 502
Query: 615 ENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAE 674
ENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAE
Sbjct: 503 ENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAE 562
Query: 675 DVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQ 734
DVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQ
Sbjct: 563 DVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQ 622
Query: 735 QNGYENPTYKFFEQMQN 751
QNGYENPTYKFFEQMQN
Sbjct: 623 QNGYENPTYKFFEQMQN 639
>gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform 2
[Homo sapiens]
Length = 751
Score = 757 bits (1955), Expect = 0.0
Identities = 399/765 (52%), Positives = 521/765 (68%), Gaps = 48/765 (6%)
Query: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
Query: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
+GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++
Sbjct: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132
Query: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176
CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+
Sbjct: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192
Query: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 236
D+F G E+VCCP + +V + EED+ + + DY D + + A+ E+ E
Sbjct: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTE 251
Query: 237 VEEEEADDDEDDEDGDEVEEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVREV 290
+E DDED+E+G+EV E+ + Y+ E T + T + + + V+ V
Sbjct: 252 AAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAA 350
CS++A TGPCRA++ RWYFD+++GKC F YGGCGGNRNNF++E+YCMAVC + IP T
Sbjct: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPL 369
Query: 351 STPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKK 410
T D VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++
Sbjct: 370 PTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQ 428
Query: 411 AVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRH 470
+IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP
Sbjct: 429 TLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHR 488
Query: 471 VFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLY 530
+ L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLLY
Sbjct: 489 ILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLY 548
Query: 531 NVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPV 590
VP VA+EIQ+E+DELLQ+++ A+M D S++ET V V
Sbjct: 549 KVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR---V 588
Query: 591 NGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLTNIKTEE 646
+ E S +++ P+H F PA ENE V + A+ + N+ +E
Sbjct: 589 SSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDE 645
Query: 647 ISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLK 705
+VK M G E + + ED + A+IGL+V V IATVIVI+LVML+
Sbjct: 646 TLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLR 705
Query: 706 KKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 750
K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 706 KRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 750
>gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1
[Homo sapiens]
Length = 763
Score = 755 bits (1950), Expect = 0.0
Identities = 403/779 (51%), Positives = 527/779 (67%), Gaps = 64/779 (8%)
Query: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
Query: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
+GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++
Sbjct: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132
Query: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176
CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+
Sbjct: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192
Query: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 236
D+F G E+VCCP + +V + EED+ + + DY D + + A+ E+ E
Sbjct: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTE 251
Query: 237 VEEEEADDDEDDEDGDEVEEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVREV 290
+E DDED+E+G+EV E+ + Y+ E T + T + + + V+ V
Sbjct: 252 AAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAA 350
CS++A TGPCRA++ RWYFD+++GKC F YGGCGGNRNNF++E+YCMAVC + IP T
Sbjct: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPL 369
Query: 351 STPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKK 410
T D VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++
Sbjct: 370 PTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQ 428
Query: 411 AVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRH 470
+IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP
Sbjct: 429 TLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHR 488
Query: 471 VFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLY 530
+ L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLLY
Sbjct: 489 ILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLY 548
Query: 531 NVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPV 590
VP VA+EIQ+E+DELLQ+++ A+M D S++ET V V
Sbjct: 549 KVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR---V 588
Query: 591 NGEFSLDDLQPWHSFGADSVPANTENE-VEPVDARPAADRGLTTRPGSGLTNIKTEEI-S 648
+ E S +++ P+H F PA ENE +P P GL + + I S
Sbjct: 589 SSEES-EEIPPFHPF--HPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINS 645
Query: 649 EVKMDAEFRHDSGYEVHHQKLVFFAEDVGS-----------------NKGAIIGLMVGGV 691
+ K+D D +V ++++F AE VG + A+IGL+V V
Sbjct: 646 KNKVDENMVIDETLDV--KEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAV 703
Query: 692 VIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 750
IATVIVI+LVML+K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 704 AIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 762
>gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform 3
[Homo sapiens]
Length = 695
Score = 641 bits (1653), Expect = 0.0
Identities = 367/760 (48%), Positives = 473/760 (62%), Gaps = 94/760 (12%)
Query: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
Query: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
+GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++
Sbjct: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132
Query: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176
CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+
Sbjct: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192
Query: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 236
D+F G E+VCCP + +V + EED+ + + D ED V +E A+
Sbjct: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEE-------EEEEEDEEEDYDVYKSEFPTEAD 245
Query: 237 VEE-EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQA 295
+E+ EA DEDDED EEE EE E+
Sbjct: 246 LEDFTEAAVDEDDED----EEEGEEVVEDRD----------------------------- 272
Query: 296 ETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDA 355
+Y+D +G G+ +E V +P T T D
Sbjct: 273 -----------YYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDV---KVPPTPLPTND- 317
Query: 356 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 415
VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++ +IQH
Sbjct: 318 VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQH 377
Query: 416 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 475
FQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP + L
Sbjct: 378 FQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQAL 437
Query: 476 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 535
++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLLY VP V
Sbjct: 438 RRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYV 497
Query: 536 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 595
A+EIQ+E+DELLQ+++ A+M D S++ET V V+ E S
Sbjct: 498 AQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR---VSSEES 537
Query: 596 LDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLTNIKTEEISEVK 651
+++ P+H F PA ENE V + A+ + N+ +E +VK
Sbjct: 538 -EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVK 594
Query: 652 -MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYT 710
M G E + + ED + A+IGL+V V IATVIVI+LVML+K+QY
Sbjct: 595 EMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYG 654
Query: 711 SIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 750
+I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 655 TISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 694
>gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform 4
[Homo sapiens]
Length = 522
Score = 383 bits (983), Expect = e-106
Identities = 215/411 (52%), Positives = 278/411 (67%), Gaps = 29/411 (7%)
Query: 345 IPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNL 404
+P T T D VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNL
Sbjct: 135 VPPTPLPTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNL 193
Query: 405 PKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAV 464
PKA+++ +IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+
Sbjct: 194 PKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSD 253
Query: 465 PPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQ 524
PPRP + L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQ
Sbjct: 254 PPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQ 313
Query: 525 SLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTT 584
SLSLLY VP VA+EIQ+E+DELLQ+++ A+M D S++ET
Sbjct: 314 SLSLLYKVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVD 356
Query: 585 VELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLT 640
V V+ E S +++ P+H F PA ENE V + A+ +
Sbjct: 357 VR---VSSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDE 410
Query: 641 NIKTEEISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVI 699
N+ +E +VK M G E + + ED + A+IGL+V V IATVIVI
Sbjct: 411 NMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVI 470
Query: 700 TLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 750
+LVML+K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 471 SLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 521
Score = 152 bits (385), Expect = 8e-37
Identities = 75/123 (60%), Positives = 93/123 (75%), Gaps = 10/123 (8%)
Query: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
Query: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
+GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++
Sbjct: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKS--RFVTPFK 132
Query: 117 CLV 119
CLV
Sbjct: 133 CLV 135
>gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor
[Homo sapiens]
Length = 651
Score = 359 bits (922), Expect = 5e-99
Identities = 257/759 (33%), Positives = 366/759 (48%), Gaps = 143/759 (18%)
Query: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
+LP L LLL A +L + G A Q+A CGRL +H +++ G+W+ DP ++
Sbjct: 23 LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82
Query: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119
C+ + +L+YC+++YPELQI V +A Q + ++ WC R HPH V+P+RCL
Sbjct: 83 RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142
Query: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179
GEFVS+ALLVP+ C+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+F
Sbjct: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202
Query: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239
RGVE+VCCP D S A D S W GS VE AE+EE E
Sbjct: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250
Query: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGP 299
+ DD + E EEE P T T T T+ V+
Sbjct: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVD--------------- 295
Query: 300 CRAMISRWYF----DVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDA 355
YF +++E + G R D EE M + A +
Sbjct: 296 -------IYFGMPGEISEHE---------GFLRAKMDLEERRMRQINEVMREWAMA---- 335
Query: 356 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 415
+N+ + KA + +H + + Q + E ERQ
Sbjct: 336 ----------DNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ--------------- 370
Query: 416 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 475
+LVETH RV A++ND+RR ALE ++ ALQA PP+ V L
Sbjct: 371 -----------------RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLAL 413
Query: 476 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 535
++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P +
Sbjct: 414 RRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHL 473
Query: 536 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 595
A+E++ ++ ELL E L PS E P G S
Sbjct: 474 AQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGGSS 504
Query: 596 LD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMD 653
D LQP S AD+ + E A P ++ + E E K++
Sbjct: 505 EDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK------------MNPLEQYERKVN 552
Query: 654 AEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKKQY 709
A G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK Y
Sbjct: 553 ASV--PRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPY 610
Query: 710 TSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 748
+I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 611 GAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 649
>gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor
[Homo sapiens]
Length = 650
Score = 356 bits (913), Expect = 5e-98
Identities = 253/759 (33%), Positives = 361/759 (47%), Gaps = 144/759 (18%)
Query: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
+LP L LLL A +L + G A Q+A CGRL +H +++ G+W+ DP ++
Sbjct: 23 LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82
Query: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119
C+ + +L+YC+++YPELQI V +A Q + ++ WC R HPH V+P+RCL
Sbjct: 83 RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142
Query: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179
GEFVS+ALLVP+ C+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+F
Sbjct: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202
Query: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239
RGVE+VCCP D S A D S W GS VE AE+EE E
Sbjct: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250
Query: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGP 299
+ DD + E EEE P T T T T+ V+
Sbjct: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVD--------------- 295
Query: 300 CRAMISRWYF----DVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDA 355
YF +++E + G R D EE M + A +
Sbjct: 296 -------IYFGMPGEISEHE---------GFLRAKMDLEERRMRQINEVMREWAMA---- 335
Query: 356 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 415
+N+ + KA + +H + + Q + E ERQ
Sbjct: 336 ----------DNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ--------------- 370
Query: 416 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 475
+LVETH RV A++ND+RR ALE ++ ALQA PP+ V L
Sbjct: 371 -----------------RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLAL 413
Query: 476 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 535
++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P +
Sbjct: 414 RRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHL 473
Query: 536 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 595
A+E++ ++ ELL E L PS E P G S
Sbjct: 474 AQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGGSS 504
Query: 596 LD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMD 653
D LQP S D P +G T + + K + + +
Sbjct: 505 EDKGGLQPPDS--KDDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYERK 549
Query: 654 AEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKKQY 709
G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK Y
Sbjct: 550 VNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPY 609
Query: 710 TSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 748
+I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 610 GAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
>gi|10863909 serine protease inhibitor, Kunitz type, 2 [Homo
sapiens]
Length = 252
Score = 72.0 bits (175), Expect = 2e-12
Identities = 39/103 (37%), Positives = 48/103 (46%), Gaps = 16/103 (15%)
Query: 255 EEEAEEPYEEATERTTS-IATTTTTTTESVEEVVR---------------EVCSEQAETG 298
+EE + TE T +AT+ SV R E C+ A TG
Sbjct: 81 KEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTG 140
Query: 299 PCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
PCRA RWYFDV C F YGGC GN+N++ +EE CM C
Sbjct: 141 PCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRC 183
Score = 64.3 bits (155), Expect = 4e-10
Identities = 25/60 (41%), Positives = 36/60 (60%)
Query: 284 EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGS 343
E + + C G CRA + RW+++VT+G C F YGGC GN NN+ T+E C+ C +
Sbjct: 31 ERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCAT 90
>gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo
sapiens]
Length = 2971
Score = 66.6 bits (161), Expect = 8e-11
Identities = 27/90 (30%), Positives = 45/90 (50%)
Query: 256 EEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGK 315
++++ P + +S +TE + ++C + G CR I +WY+D
Sbjct: 2871 KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 2930
Query: 316 CAPFFYGGCGGNRNNFDTEEYCMAVCGSAI 345
CA F+YGGCGGN N F +++ C VC +
Sbjct: 2931 CARFWYGGCGGNENKFGSQKECEKVCAPVL 2960
>gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo
sapiens]
Length = 3177
Score = 66.6 bits (161), Expect = 8e-11
Identities = 27/90 (30%), Positives = 45/90 (50%)
Query: 256 EEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGK 315
++++ P + +S +TE + ++C + G CR I +WY+D
Sbjct: 3077 KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 3136
Query: 316 CAPFFYGGCGGNRNNFDTEEYCMAVCGSAI 345
CA F+YGGCGGN N F +++ C VC +
Sbjct: 3137 CARFWYGGCGGNENKFGSQKECEKVCAPVL 3166
>gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo
sapiens]
Length = 2570
Score = 66.6 bits (161), Expect = 8e-11
Identities = 27/90 (30%), Positives = 45/90 (50%)
Query: 256 EEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGK 315
++++ P + +S +TE + ++C + G CR I +WY+D
Sbjct: 2470 KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 2529
Query: 316 CAPFFYGGCGGNRNNFDTEEYCMAVCGSAI 345
CA F+YGGCGGN N F +++ C VC +
Sbjct: 2530 CARFWYGGCGGNENKFGSQKECEKVCAPVL 2559
>gi|189571689 serine protease inhibitor, Kunitz type, 3 [Homo
sapiens]
Length = 89
Score = 66.6 bits (161), Expect = 8e-11
Identities = 25/61 (40%), Positives = 40/61 (65%)
Query: 281 ESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAV 340
+++++++ VC+ E GPC+ ++RW+F+ G+C F YGGCGGN NNF +E C
Sbjct: 26 DTIKDLLPNVCAFPMEKGPCQTYMTRWFFNFETGECELFAYGGCGGNSNNFLRKEKCEKF 85
Query: 341 C 341
C
Sbjct: 86 C 86
>gi|32313599 serine peptidase inhibitor, Kunitz type 1 isoform 1
precursor [Homo sapiens]
Length = 529
Score = 64.3 bits (155), Expect = 4e-10
Identities = 33/100 (33%), Positives = 45/100 (45%), Gaps = 4/100 (4%)
Query: 270 TSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRN 329
T+ T T +T+ E+ C + G CR RWY+D TE C F YGGC GN+N
Sbjct: 233 TANVTVTVLSTKQTEDY----CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKN 288
Query: 330 NFDTEEYCMAVCGSAIPTTAASTPDAVDKYLETPGDENEH 369
N+ EE C+ C + A + + P E H
Sbjct: 289 NYLREEECILACRGVQGGPLRGSSGAQATFPQGPSMERRH 328
Score = 60.1 bits (144), Expect = 7e-09
Identities = 23/51 (45%), Positives = 32/51 (62%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
C + +TG C+ I RWY++ CA F YGGC GN+NNF+ E+ C+ C
Sbjct: 391 CVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESC 441
>gi|74027265 serine peptidase inhibitor, Kunitz type 1 isoform 2
precursor [Homo sapiens]
Length = 513
Score = 63.2 bits (152), Expect = 9e-10
Identities = 29/72 (40%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Query: 270 TSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRN 329
T+ T T +T+ E+ C + G CR RWY+D TE C F YGGC GN+N
Sbjct: 233 TANVTVTVLSTKQTEDY----CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKN 288
Query: 330 NFDTEEYCMAVC 341
N+ EE C+ C
Sbjct: 289 NYLREEECILAC 300
Score = 60.1 bits (144), Expect = 7e-09
Identities = 23/51 (45%), Positives = 32/51 (62%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
C + +TG C+ I RWY++ CA F YGGC GN+NNF+ E+ C+ C
Sbjct: 375 CVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESC 425
>gi|4504329 serine peptidase inhibitor, Kunitz type 1 isoform 2
precursor [Homo sapiens]
Length = 513
Score = 63.2 bits (152), Expect = 9e-10
Identities = 29/72 (40%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Query: 270 TSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRN 329
T+ T T +T+ E+ C + G CR RWY+D TE C F YGGC GN+N
Sbjct: 233 TANVTVTVLSTKQTEDY----CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKN 288
Query: 330 NFDTEEYCMAVC 341
N+ EE C+ C
Sbjct: 289 NYLREEECILAC 300
Score = 60.1 bits (144), Expect = 7e-09
Identities = 23/51 (45%), Positives = 32/51 (62%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
C + +TG C+ I RWY++ CA F YGGC GN+NNF+ E+ C+ C
Sbjct: 375 CVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESC 425
>gi|154759255 collagen, type XXVIII precursor [Homo sapiens]
Length = 1125
Score = 63.2 bits (152), Expect = 9e-10
Identities = 32/111 (28%), Positives = 55/111 (49%), Gaps = 4/111 (3%)
Query: 231 EEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREV 290
++E++E D DEDD+ + + + P ++E TT+ +T + E+
Sbjct: 1016 QKEISESLSVTRDQDEDDKAPEPTWAD-DLPATTSSEATTTPRPLLSTPVDGAED---PR 1071
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
C E + G C + RWY+D CA F++ GC G+ N F++E+ C C
Sbjct: 1072 CLEALKPGNCGEYVVRWYYDKQVNSCARFWFSGCNGSGNRFNSEKECQETC 1122
>gi|31563528 serine peptidase inhibitor-like, with Kunitz and WAP
domains 1 isoform 2 [Homo sapiens]
Length = 117
Score = 62.4 bits (150), Expect = 1e-09
Identities = 23/57 (40%), Positives = 34/57 (59%)
Query: 285 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
++ ++VC ETGPC A W++D + C+ F YGGC GN NNF ++ C+ C
Sbjct: 55 DLKQDVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTC 111
>gi|10732863 serine peptidase inhibitor-like, with Kunitz and WAP
domains 1 isoform 1 precursor [Homo sapiens]
Length = 133
Score = 62.4 bits (150), Expect = 1e-09
Identities = 23/57 (40%), Positives = 34/57 (59%)
Query: 285 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
++ ++VC ETGPC A W++D + C+ F YGGC GN NNF ++ C+ C
Sbjct: 71 DLKQDVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTC 127
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 61.6 bits (148), Expect = 3e-09
Identities = 32/104 (30%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAA 350
C + G C +RWYF + G+C F+YGGC GN NNF +E+ CM+ C ++
Sbjct: 727 CLLPSAHGSCADWAARWYFVASVGQCNRFWYGGCHGNANNFASEQECMSSCQGSLHGPRR 786
Query: 351 STPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREW 394
P A + T G + A E+ ++HR + + W
Sbjct: 787 PQPGASGRSTHTDGGGS-----SPAGEQEPSQHRTGAAVQRKPW 825
>gi|4502067 alpha-1-microglobulin/bikunin preproprotein [Homo
sapiens]
Length = 352
Score = 61.2 bits (147), Expect = 3e-09
Identities = 26/52 (50%), Positives = 30/52 (57%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCG 342
C+ GPCRA I W FD +GKC F YGGC GN N F +E+ C CG
Sbjct: 287 CNLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGNGNKFYSEKECREYCG 338
Score = 55.8 bits (133), Expect = 1e-07
Identities = 29/81 (35%), Positives = 37/81 (45%), Gaps = 8/81 (9%)
Query: 261 PYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFF 320
P EE + T T +S C GPC M SR++++ T C F
Sbjct: 209 PQEEEGSGGGQLVTEVTKKEDS--------CQLGYSAGPCMGMTSRYFYNGTSMACETFQ 260
Query: 321 YGGCGGNRNNFDTEEYCMAVC 341
YGGC GN NNF TE+ C+ C
Sbjct: 261 YGGCMGNGNNFVTEKECLQTC 281
>gi|73760409 tissue factor pathway inhibitor isoform b precursor
[Homo sapiens]
Length = 251
Score = 60.8 bits (146), Expect = 4e-09
Identities = 24/68 (35%), Positives = 42/68 (61%)
Query: 274 TTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDT 333
T T T +++ C+ +A+ GPC+A++ R++F++ +C F YGGC GN+N F++
Sbjct: 37 TIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFES 96
Query: 334 EEYCMAVC 341
E C +C
Sbjct: 97 LEECKKMC 104
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 251 GDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFD 310
G E + E EE + T T ++++ + C + + G CR I+R++++
Sbjct: 86 GCEGNQNRFESLEECKKMCTRDNANRIIKT-TLQQEKPDFCFLEEDPGICRGYITRYFYN 144
Query: 311 VTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
+C F YGGC GN NNF+T E C +C
Sbjct: 145 NQTKQCERFKYGGCLGNMNNFETLEECKNIC 175
>gi|5454114 tissue factor pathway inhibitor isoform a precursor
[Homo sapiens]
Length = 304
Score = 60.8 bits (146), Expect = 4e-09
Identities = 24/68 (35%), Positives = 42/68 (61%)
Query: 274 TTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDT 333
T T T +++ C+ +A+ GPC+A++ R++F++ +C F YGGC GN+N F++
Sbjct: 37 TIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFES 96
Query: 334 EEYCMAVC 341
E C +C
Sbjct: 97 LEECKKMC 104
Score = 60.8 bits (146), Expect = 4e-09
Identities = 24/51 (47%), Positives = 33/51 (64%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
C A+ G CRA +R+Y++ GKC PF Y GCGGN NNF +++ C+ C
Sbjct: 217 CLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRAC 267
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 251 GDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFD 310
G E + E EE + T T ++++ + C + + G CR I+R++++
Sbjct: 86 GCEGNQNRFESLEECKKMCTRDNANRIIKT-TLQQEKPDFCFLEEDPGICRGYITRYFYN 144
Query: 311 VTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
+C F YGGC GN NNF+T E C +C
Sbjct: 145 NQTKQCERFKYGGCLGNMNNFETLEECKNIC 175
>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
Length = 2944
Score = 59.7 bits (143), Expect = 1e-08
Identities = 39/111 (35%), Positives = 45/111 (40%), Gaps = 20/111 (18%)
Query: 234 VAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSE 293
V+ EEEE EDDE + E EE Y++ S + CS
Sbjct: 2836 VSHAEEEERVPPEDDEYSEYSEYSVEE-YQDPEAPWDS----------------DDPCSL 2878
Query: 294 QAETGPCRAMISRWYFDVTEGK---CAPFFYGGCGGNRNNFDTEEYCMAVC 341
+ G C A RWY G C PF YGGCGGN N F T E C C
Sbjct: 2879 PLDEGSCTAYTLRWYHRAVTGSTEACHPFVYGGCGGNANRFGTREACERRC 2929
>gi|5730091 tissue factor pathway inhibitor 2 [Homo sapiens]
Length = 235
Score = 58.9 bits (141), Expect = 2e-08
Identities = 25/53 (47%), Positives = 31/53 (58%)
Query: 289 EVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
E+C + GPCRA++ R+Y+D C F YGGC GN NNF T E C C
Sbjct: 34 EICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDDAC 86
Score = 51.6 bits (122), Expect = 3e-06
Identities = 22/55 (40%), Positives = 29/55 (52%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAI 345
C + G C A ++R+YF+ C F Y GCGGN NNF + E C C A+
Sbjct: 158 CYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKAL 212
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/74 (33%), Positives = 33/74 (44%), Gaps = 4/74 (5%)
Query: 285 EVVREVCSEQAETGP-CRAMISRWYFDVTEGKCAPFFYGGCGGNR--NNFDTEEYCMAVC 341
E V +VC Q C +++F+++ C FF GGC NR N F E CM C
Sbjct: 90 EKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFPDEATCMGFC 149
Query: 342 G-SAIPTTAASTPD 354
IP+ S D
Sbjct: 150 APKKIPSFCYSPKD 163
>gi|28212222 WFIKKN2 protein [Homo sapiens]
Length = 576
Score = 58.5 bits (140), Expect = 2e-08
Identities = 24/51 (47%), Positives = 30/51 (58%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
CS A GPC+A RW ++ G+C F YGGC GN NNF++ E C C
Sbjct: 386 CSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNGNNFESREACEESC 436
Score = 48.9 bits (115), Expect = 2e-05
Identities = 23/63 (36%), Positives = 31/63 (49%), Gaps = 1/63 (1%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAA 350
C + ++ C +RW+FD C F +G C N N+F+T E CM C S P A
Sbjct: 328 CLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGHCHRNLNHFETYEACMLACMSG-PLAAC 386
Query: 351 STP 353
S P
Sbjct: 387 SLP 389
>gi|60498973 myelin transcription factor 1-like [Homo sapiens]
Length = 1184
Score = 57.0 bits (136), Expect = 6e-08
Identities = 32/77 (41%), Positives = 44/77 (57%), Gaps = 2/77 (2%)
Query: 191 EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDED 250
++SD + D +E+D + D D G ED+ E + EE E+EEE+ DDDED ED
Sbjct: 91 DDSDGTEDMDEKEEDEGEEYS-EDND-EPGDEDEEDEEGDREEEEEIEEEDEDDDEDGED 148
Query: 251 GDEVEEEAEEPYEEATE 267
++ EEE EE EE E
Sbjct: 149 VEDEEEEEEEEEEEEEE 165
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/121 (28%), Positives = 50/121 (41%), Gaps = 17/121 (14%)
Query: 187 CPLAEESDNVDSADAEE-----------DDSDVWWGGADTDYADGSEDKVVEVAEEEEVA 235
CPLA++ D E D S V + D +DG+ED ++ EE+E
Sbjct: 55 CPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSV----DECDDSDGTED--MDEKEEDEGE 108
Query: 236 EVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQA 295
E E+ + ++DE+ +E + E EE EE E E EE E E+
Sbjct: 109 EYSEDNDEPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEEN 168
Query: 296 E 296
E
Sbjct: 169 E 169
Score = 36.2 bits (82), Expect = 0.11
Identities = 30/116 (25%), Positives = 49/116 (42%), Gaps = 26/116 (22%)
Query: 191 EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEE--------- 241
EE D + + EE+D D D D D +++ E EEEE E E E+
Sbjct: 125 EEGDREEEEEIEEEDED-----DDEDGEDVEDEEEEEEEEEEEEEEEENEDHQMNCHNTR 179
Query: 242 --ADDDEDDEDGDEVEEEAE----------EPYEEATERTTSIATTTTTTTESVEE 285
D ++DD + DE + E + E+A R + + + T+ S+E+
Sbjct: 180 IMQDTEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEMNSNTSNSLED 235
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,193,768
Number of Sequences: 37866
Number of extensions: 1390432
Number of successful extensions: 20583
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 470
Number of HSP's successfully gapped in prelim test: 379
Number of HSP's that attempted gapping in prelim test: 9529
Number of HSP's gapped (non-prelim): 5657
length of query: 751
length of database: 18,247,518
effective HSP length: 110
effective length of query: 641
effective length of database: 14,082,258
effective search space: 9026727378
effective search space used: 9026727378
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.