Search of human proteins with 40795667

Search of human proteins with 40795667

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40795667 ubiquitin specific protease 4 isoform b [Homo
sapiens]
         (916 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]   1896   0.0  
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]   1871   0.0  
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]           1105   0.0  
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]            803   0.0  
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]                  399   e-111
gi|22550104 ubiquitin specific protease 32 [Homo sapiens]             290   3e-78
gi|109638751 ubiquitin specific protease 6 [Homo sapiens]             262   1e-69
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]            189   1e-47
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]            189   1e-47
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]            189   1e-47
gi|148612811 ubiquitin specific protease 43 [Homo sapiens]            167   3e-41
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]           165   2e-40
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi...   160   5e-39
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]   158   2e-38
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]                  140   4e-33
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]             127   4e-29
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]             127   4e-29
gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens]           127   5e-29
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]   118   3e-26
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]   118   3e-26
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]   118   3e-26
gi|183396780 ubiquitin specific protease 20 [Homo sapiens]            112   1e-24
gi|183397136 ubiquitin specific protease 20 [Homo sapiens]            112   1e-24
gi|183397134 ubiquitin specific protease 20 [Homo sapiens]            112   1e-24
gi|239751420 PREDICTED: similar to hCG2039376 [Homo sapiens]          100   8e-21
gi|45267835 ubiquitin specific protease 50 [Homo sapiens]              96   2e-19
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]    90   8e-18
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]     90   8e-18
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]    90   8e-18
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]                 88   3e-17

>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
          Length = 916

 Score = 1896 bits (4911), Expect = 0.0
 Identities = 916/916 (100%), Positives = 916/916 (100%)

Query: 1   MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG 60
           MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG
Sbjct: 1   MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG 60

Query: 61  EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK 120
           EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK
Sbjct: 61  EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK 120

Query: 121 VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE 180
           VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE
Sbjct: 121 VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE 180

Query: 181 TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSNGSGFSASY 240
           TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSNGSGFSASY
Sbjct: 181 TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSNGSGFSASY 240

Query: 241 NCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGM 300
           NCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGM
Sbjct: 241 NCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGM 300

Query: 301 KGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHE 360
           KGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHE
Sbjct: 301 KGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHE 360

Query: 361 DLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKV 420
           DLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKV
Sbjct: 361 DLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKV 420

Query: 421 SVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSG 480
           SVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSG
Sbjct: 421 SVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSG 480

Query: 481 IAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRER 540
           IAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRER
Sbjct: 481 IAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRER 540

Query: 541 KSRPSSTSSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPG 600
           KSRPSSTSSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPG
Sbjct: 541 KSRPSSTSSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPG 600

Query: 601 ACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLF 660
           ACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLF
Sbjct: 601 ACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLF 660

Query: 661 TFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQ 720
           TFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQ
Sbjct: 661 TFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQ 720

Query: 721 PQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKR 780
           PQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKR
Sbjct: 721 PQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKR 780

Query: 781 FSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAK 840
           FSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAK
Sbjct: 781 FSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAK 840

Query: 841 NKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSS 900
           NKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSS
Sbjct: 841 NKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSS 900

Query: 901 SQQGFGDDEACSMDTN 916
           SQQGFGDDEACSMDTN
Sbjct: 901 SQQGFGDDEACSMDTN 916


>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
          Length = 963

 Score = 1871 bits (4847), Expect = 0.0
 Identities = 915/963 (95%), Positives = 915/963 (95%), Gaps = 47/963 (4%)

Query: 1   MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG 60
           MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG
Sbjct: 1   MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG 60

Query: 61  EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK 120
           EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK
Sbjct: 61  EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK 120

Query: 121 VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE 180
           VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE
Sbjct: 121 VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE 180

Query: 181 TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSN-------- 232
           TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQS         
Sbjct: 181 TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRN 240

Query: 233 ---------------------------------------GSGFSASYNCQEPPSSHIQPG 253
                                                  GSGFSASYNCQEPPSSHIQPG
Sbjct: 241 FTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPG 300

Query: 254 LCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIK 313
           LCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIK
Sbjct: 301 LCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIK 360

Query: 314 QMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL 373
           QMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL
Sbjct: 361 QMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL 420

Query: 374 KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLP 433
           KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLP
Sbjct: 421 KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLP 480

Query: 434 LPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN 493
           LPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN
Sbjct: 481 LPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN 540

Query: 494 HRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASAL 553
           HRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASAL
Sbjct: 541 HRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASAL 600

Query: 554 YGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGED 613
           YGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGED
Sbjct: 601 YGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGED 660

Query: 614 EEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADI 673
           EEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADI
Sbjct: 661 EEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADI 720

Query: 674 NSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRD 733
           NSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRD
Sbjct: 721 NSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRD 780

Query: 734 CIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDT 793
           CIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDT
Sbjct: 781 CIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDT 840

Query: 794 VVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDS 853
           VVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDS
Sbjct: 841 VVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDS 900

Query: 854 NVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSM 913
           NVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSM
Sbjct: 901 NVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSM 960

Query: 914 DTN 916
           DTN
Sbjct: 961 DTN 963


>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
          Length = 952

 Score = 1105 bits (2857), Expect = 0.0
 Identities = 553/912 (60%), Positives = 680/912 (74%), Gaps = 42/912 (4%)

Query: 1   MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG 60
           MAEGG      D +TQ+S++  L++T+L++G  WYL+DSRWFKQWKKYVGFDSWD Y +G
Sbjct: 1   MAEGGAA----DLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMG 56

Query: 61  EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK 120
           + N++PGPIDNSGL  D ++Q+LKEHLIDELDY+L+PTE WNKL++WY  +EGQ+PI RK
Sbjct: 57  DQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWYTLMEGQEPIARK 116

Query: 121 VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE 180
           VVE G+FVKHCKVEVYL ELKLCEN +  NV++  FSKADTI TIEKE+RK+F+IP E+E
Sbjct: 117 VVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKE 176

Query: 181 TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSNGSGFS--- 237
           TRLWNKYMSNT+E L+K D+T+QDAGLYQGQVLVIE +NEDGTWPR     N    +   
Sbjct: 177 TRLWNKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPNVKNSNYCL 236

Query: 238 ------ASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAE 291
                  +Y+  EP  ++ QPGLCGL NLGNTCFMNSA+QCLSNT PLT+YFL D+Y+ E
Sbjct: 237 PSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEE 296

Query: 292 INRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELL 351
           +N DNPLGM+GEIA++YAELIKQMWSG+ ++V PR FKTQVGRFAPQFSGYQQQD QELL
Sbjct: 297 LNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELL 356

Query: 352 AFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKST 411
           AFLLDGLHEDLNR++KKPY++LKDA+GRPD VVA+EAWENH  RNDS+IVD FHGLFKST
Sbjct: 357 AFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKST 416

Query: 412 LVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDL 471
           LVCPECAK+SVTFDPFCYLTLPLP+KK+R +EV+LV  DP  +P QY+V VP +G + DL
Sbjct: 417 LVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDL 476

Query: 472 CEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECV 531
           C ALS LSGI A+ M+V D+YNHRFH+IF MDE L+ IM RDDI+V+E+     + +E V
Sbjct: 477 CTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHV 536

Query: 532 TLPVYFRERKSRPSST-SSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPD 590
            +PV  RE+    S T  + S+L+GQP L++VP++  T + LY  +  R+ RYVK     
Sbjct: 537 IIPVCLREKFRHSSYTHHTGSSLFGQPFLMAVPRNN-TEDKLYNLLLLRMCRYVKISTET 595

Query: 591 EFGSSPLE-----------PGACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGS-GEDEP 638
           E     L            P   +   +  E E +E  +   + +E  SE E S  ED  
Sbjct: 596 EETEGSLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSV 655

Query: 639 GNDPSE----TTQKKIKGQPC--PKRLFTFSLVNSYGTADIN-------SLAADGKLLKL 685
           G D        T+   KGQ     KRLFTF   N+ G  DIN        +  D + L+L
Sbjct: 656 GGDNDSENGLCTEDTCKGQLTGHKKRLFTFQF-NNLGNTDINYIKDDTRHIRFDDRQLRL 714

Query: 686 NSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLG 745
           + RS LA+DWD + ++ Y+DE  +E +EKH S ++ +  KK  V L+DCIELFTT E LG
Sbjct: 715 DERSFLALDWDPDLKKRYFDENAAEDFEKHES-VEYKPPKKPFVKLKDCIELFTTKEKLG 773

Query: 746 EHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMS 805
             DPWYCPNCK+HQQATKK DLWSLP +LVVHLKRFSY+RY RDKLDT+V+FPI  L+MS
Sbjct: 774 AEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMS 833

Query: 806 EFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVT 865
           EF+ N +A P  Y+LIAVSNHYG MG GHYTA+AKNK +GKWYYFDDS+VS ASEDQIV+
Sbjct: 834 EFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVS 893

Query: 866 KAAYVLFYQRRD 877
           KAAYVLFYQR+D
Sbjct: 894 KAAYVLFYQRQD 905


>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
          Length = 963

 Score =  803 bits (2075), Expect = 0.0
 Identities = 435/903 (48%), Positives = 574/903 (63%), Gaps = 75/903 (8%)

Query: 28  LQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHL 87
           L+ G  W+L++  W+KQW+ YV     D       + FPG I+N+ LF D  +  LKE L
Sbjct: 96  LRAGESWFLVEKHWYKQWEAYVQGGDQDS------STFPGCINNATLFQDEINWRLKEGL 149

Query: 88  IDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEHGLFVKHCKVEVYLLELKLCENSD 147
           ++  DYVL+P  AW+ L++WYG   GQ PI RKV+E        KVEVY +EL L  ++D
Sbjct: 150 VEGEDYVLLPAAAWHYLVSWYGLEHGQPPIERKVIE---LPNIQKVEVYPVELLLVRHND 206

Query: 148 PTNVLSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTVQDAGL 207
                +  FS  D+I  + +  R+ F +  + +TRLW K    + ++L     TV DA L
Sbjct: 207 LGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDAAL 266

Query: 208 YQGQVLVIEPQNEDGTWPRQTLQSNGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMN 267
             GQ++++E + +DGTWP   L    +  S     +E      QPG+CGL NLGNTCFMN
Sbjct: 267 ETGQLIIMETRKKDGTWPSAQLHVMNNNMS-----EEDEDFKGQPGICGLTNLGNTCFMN 321

Query: 268 SALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRM 327
           SALQCLSN   LT+YFL + Y  E+N  NPLGMKGEIAEAYA+L+KQ WSG    + P +
Sbjct: 322 SALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHV 381

Query: 328 FKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKE 387
           FK +VG FA QF GYQQ DSQELL+FLLDGLHEDLNRVKKK Y+EL DA GRPD  VA+E
Sbjct: 382 FKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQE 441

Query: 388 AWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLV 447
           AW+NH+ RNDSVIVDTFHGLFKSTLVCP+C  VSVTFDPFCYL++PLP+   RV+EVF +
Sbjct: 442 AWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFI 501

Query: 448 PADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLN 507
           P DP  +P Q+R+ VP  G +SDLC ALS+ +GI+ E M+VADV++HRF+K++Q++E L+
Sbjct: 502 PMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPERMMVADVFSHRFYKLYQLEEPLS 561

Query: 508 HIMPRDDIFVYEVCS--TSVDGS-ECVTLPVYFRERKSRPSSTSS--ASALYGQPLLLSV 562
            I+ RDDIFVYEV     +++GS E + +PVY RER       +S     L+G PLL+SV
Sbjct: 562 SILDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRERTPARDYNNSYYGLMLFGHPLLVSV 621

Query: 563 PKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGEDEEEMEHQEE 622
           P+ + T E LY  +  R+SRYV +P                   NS + +D +E E  EE
Sbjct: 622 PRDRFTWEGLYNVLMYRLSRYVTKP-------------------NSDDEDDGDEKEDDEE 662

Query: 623 GKEQL--SETEGSGEDEPGNDPSETTQKKIKGQPCP------------------KRLFTF 662
            K+ +    T GS  D    +P +          CP                  K+LFT 
Sbjct: 663 DKDDVPGPSTGGSLRDP---EPEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTL 719

Query: 663 SLVNSYGTADINSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQ 722
             VNS GT+D  +   +     ++++  +A+DW+ E ++ YYDE E+E Y KH  +    
Sbjct: 720 QTVNSNGTSDRTTSPEE-----VHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCV--GY 772

Query: 723 KKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFS 782
             KK  V L++CIELFTT+ETL + +PWYCP+CK+HQ ATKK DLW LP+IL++HLKRFS
Sbjct: 773 VMKKAPVRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFS 832

Query: 783 YNRYWRDKLDTVVEFPIRGLNMSEFVC----NLSARPYVYDLIAVSNHYGAMGVGHYTAY 838
           Y ++ R+KLDT+VEFPIR L+ SEFV       +   Y YDLIAVSNHYG M  GHYT +
Sbjct: 833 YTKFSREKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTF 892

Query: 839 AKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRP 898
           A NK +G+W+YFDD++VS  +E+QI +KAAYVLFYQR+D        LS +GSS     P
Sbjct: 893 ACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQD---VARRLLSPAGSSGAPASP 949

Query: 899 SSS 901
           + S
Sbjct: 950 ACS 952


>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
          Length = 1318

 Score =  399 bits (1024), Expect = e-111
 Identities = 266/739 (35%), Positives = 370/739 (50%), Gaps = 106/739 (14%)

Query: 252  PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 311
            PG  GL NLGNTCFMNS +Q LSNT  L D+F    +EAEIN +NPLG  G +A  +A L
Sbjct: 494  PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVL 553

Query: 312  IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
            ++ +W G      P   K  V   A QF+GY Q D+QE +AFLLDGLHEDLNR++ KPY 
Sbjct: 554  LRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYT 613

Query: 372  ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 431
            E  D++GRPD VVA+EAW+ H++RNDS IVD F G +KS LVCP CAKVS+TFDPF YL 
Sbjct: 614  ETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLP 673

Query: 432  LPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGA-VSDLCEALSRLSGIAAENMVVAD 490
            +PLP +K +V+ VF    +PH +P ++ V+V    +  S++ ++LS+   +  EN+ +A+
Sbjct: 674  VPLP-QKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAE 732

Query: 491  VYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVY-------------- 536
            V  +RFH++F     L+ + P D +  +E+ S+ +     V L V               
Sbjct: 733  VIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCA 792

Query: 537  --FRERKSRPSSTSSASALY--------------------------GQPLLLSVPKHKLT 568
               R+++S        +  Y                          G P L+SVP  +LT
Sbjct: 793  ACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLT 852

Query: 569  LESLYQAV--CDRISRYVKQPLPDEFGSSPLE---PGACN-GSRNSCEGEDEEE------ 616
               L Q +    R S  V QP P + G   LE   PG     S  S E  D E       
Sbjct: 853  YARLAQLLEGYARYSVSVFQP-PFQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPP 911

Query: 617  ----MEHQEEGKEQL-------------------SETEGSGEDEPGNDPS----ETTQKK 649
                +    EG   L                   SE   SG  E G+ P+       +  
Sbjct: 912  ELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAA 971

Query: 650  IKGQPCPKRLFTFSLVNSYGTADINSLAADGKL-------LKLNSRSTLAMDWDSETRR- 701
            + G   P      +    +    I+S   + +L       L+L    +LA+ W +  R  
Sbjct: 972  VPGYQHPSEAMN-AHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQ 1030

Query: 702  --LYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQ 759
              +    +E E  E   S  +  +    T  L  C+ LFT  E L   + WYCP CK+H+
Sbjct: 1031 EFVLVASKELECAEDPGSAGEAARAGHFT--LDQCLNLFTRPEVLAPEEAWYCPQCKQHR 1088

Query: 760  QATKKFDLWSLPKILVVHLKRFSYNRY-WRDKLDTVVEFPIRGLNMSEFVCNLSARPY-V 817
            +A+K+  LW LP +L+V LKRFS+  + WRDK++ +VEFP+R L++S+F           
Sbjct: 1089 EASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPS 1148

Query: 818  YDLIAVSNHYGAMGVGHYTAYAK-------NKLNGKWYYFDDSNVSLASEDQIVTKAAYV 870
            YDL AV NHYG M  GHYTA A+        + +  W  FDDS V+   E Q+VT+ AYV
Sbjct: 1149 YDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYV 1208

Query: 871  LFYQRRDDEFYKTPSLSSS 889
            LFY+RR+    + P    S
Sbjct: 1209 LFYRRRNSPVERPPRAGHS 1227


>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
          Length = 1604

 Score =  290 bits (743), Expect = 3e-78
 Identities = 171/463 (36%), Positives = 256/463 (55%), Gaps = 49/463 (10%)

Query: 66  PGPIDNSGLFSDP---------ESQTLKE--HLIDELDYVLVPTEAWNKLLNWYGC-VEG 113
           PG IDN  L +           E   LK    LI   DY +VP   W  L +WYG  +  
Sbjct: 521 PGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLAL 580

Query: 114 QQPIVRK----VVEHGLFVKHCKVEVYLLELKLCENSDPTNV------------------ 151
            +P+++     + E  LF ++    +  L  +    +  +N+                  
Sbjct: 581 PRPVIKNSKTDIPELELFPRY----LLFLRQQPATRTQQSNIWVNMGNVPSPNAPLKRVL 636

Query: 152 --LSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTVQDAGLYQ 209
               C FS+  TI  I + + +   I  E + RLW     N    L   D+ ++   +  
Sbjct: 637 AYTGC-FSRMQTIKEIHEYLSQRLRIK-EEDMRLWLYNSENYLTLLDDEDHKLEYLKIQD 694

Query: 210 GQVLVIEPQNEDGTWPRQTLQSNGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSA 269
            Q LVIE +N+D +WP +        F A+ +  +      + G  GL NLGNTCFMNS+
Sbjct: 695 EQHLVIEVRNKDMSWPEEM------SFIANSSKIDRHKVPTEKGATGLSNLGNTCFMNSS 748

Query: 270 LQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFK 329
           +QC+SNT PLT YF+   +  E+NR NP+GMKG +A+ Y +L++++WSG   +VAP   +
Sbjct: 749 IQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLR 808

Query: 330 TQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAW 389
             + ++AP+F+G+QQQDSQELLAFLLDGLHEDLNRV +KPY+ELKD++GRPD  VA EAW
Sbjct: 809 WTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAW 868

Query: 390 ENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPA 449
           +NH  RN S++VD FHG  +S + C  C  +SV FDPF +L+LPLP+     +E+ ++  
Sbjct: 869 DNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKL 928

Query: 450 DPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVY 492
           D    P +Y + + +    + L + LS L G+ +E +++A+V+
Sbjct: 929 D-GTTPVRYGLRLNMDEKYTGLKKQLSDLCGLNSEQILLAEVH 970



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 46/119 (38%), Positives = 68/119 (57%), Gaps = 2/119 (1%)

Query: 691  LAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPW 750
            +A+DWD     L Y   +    ++H S+ Q ++ +   + L  C+  FT+ E LGE++ +
Sbjct: 1195 IAVDWDPTALHLRYQTSQERVVDEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEMY 1254

Query: 751  YCPNCKKHQQATKKFDLWSLPKILVVHLKRFSY-NRYWRDKLDTVVEFPIRGLNMSEFV 808
            YC  CK H  ATKK DLW LP IL++HLKRF + N  W  K   +V+FP    + S F+
Sbjct: 1255 YCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW-IKSQKIVKFPRESFDPSAFL 1312



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 28/64 (43%), Positives = 43/64 (67%), Gaps = 1/64 (1%)

Query: 817  VYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRR 876
            +Y+L A+S H G +G GHY  YAKN  N KWY ++DS+      D+I T +AY+LFY+++
Sbjct: 1509 IYNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQ 1567

Query: 877  DDEF 880
              ++
Sbjct: 1568 GIDY 1571



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 13/29 (44%), Positives = 21/29 (72%)

Query: 25  RTTLQRGAQWYLIDSRWFKQWKKYVGFDS 53
           R  LQ G  W++I  +W++QWK+YV +D+
Sbjct: 387 RYGLQAGHNWFIISMQWWQQWKEYVKYDA 415


>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
          Length = 1406

 Score =  262 bits (669), Expect = 1e-69
 Identities = 127/278 (45%), Positives = 185/278 (66%), Gaps = 7/278 (2%)

Query: 216 EPQNEDGTWPRQTLQSNGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSN 275
           E  N+D +WP +        F+A+ +  +      + G  GL NLGNTCFMNS++QC+SN
Sbjct: 499 EVHNKDMSWPEEM------SFTANSSKIDRQKVPTEKGATGLSNLGNTCFMNSSIQCVSN 552

Query: 276 TAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRF 335
           T PLT YF+   +  E+NR NP+GMKG +A+ Y +L++++WSG    VAP   +  + ++
Sbjct: 553 TQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKY 612

Query: 336 APQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLR 395
           AP+F G+QQQDSQELLAFLLDGLHEDLNRV +KPY+ELKD++GRPD  VA EAW+NH  R
Sbjct: 613 APKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRR 672

Query: 396 NDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRP 455
           N S+IVD FHG  +S + C  C  +SV FDPF +L+LPLP+     +E+ ++  D    P
Sbjct: 673 NRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLEITVIKLD-GTTP 731

Query: 456 TQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN 493
            +Y + + +    + L + L  L G+ +E +++A+V++
Sbjct: 732 VRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEVHD 769



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 44/119 (36%), Positives = 63/119 (52%), Gaps = 2/119 (1%)

Query: 691  LAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPW 750
            +A+DW      L Y   +    +KH S+ Q ++ +   + L  C+  FT+ E LGE + +
Sbjct: 993  IAVDWHPTALHLRYQTSQERVVDKHESVEQSRRAQAEPINLDSCLRAFTSEEELGESEMY 1052

Query: 751  YCPNCKKHQQATKKFDLWSLPKILVVHLKRFSY-NRYWRDKLDTVVEFPIRGLNMSEFV 808
            YC  CK H  ATKK DLW LP  L++HLKRF + N  W  K   +V F     + S F+
Sbjct: 1053 YCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQW-IKSQKIVRFLRESFDPSAFL 1110



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 30/90 (33%), Positives = 51/90 (56%), Gaps = 2/90 (2%)

Query: 817  VYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRR 876
            +Y+L A+S H G +  GHY  YAKN  N KWY ++DS+      D+I T +AY+LFY+++
Sbjct: 1311 IYNLYAISCHSGILSGGHYITYAKNP-NCKWYCYNDSSCEELHPDEIDTDSAYILFYEQQ 1369

Query: 877  DDEFYK-TPSLSSSGSSDGGTRPSSSQQGF 905
              ++ +  P +     +D  +    S+  +
Sbjct: 1370 GIDYAQFLPKIDGKKMADTSSTDEDSESDY 1399


>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  189 bits (480), Expect = 1e-47
 Identities = 90/183 (49%), Positives = 124/183 (67%)

Query: 252 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 311
           P L GL NLGNTC+MNS LQCL N   L DYF ++ Y+ +INR N LG KGE+AE +  +
Sbjct: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGII 833

Query: 312 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
           +K +W+G+  +++P+ FK  +G+   QF+GY QQDSQELL FL+DGLHEDLN+   +   
Sbjct: 834 MKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRY 893

Query: 372 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 431
           + ++ +   D   A+ AW+ H+  N+S+IV  F G FKST+ C  C K S TF+ F YL+
Sbjct: 894 KEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLS 953

Query: 432 LPL 434
           LPL
Sbjct: 954 LPL 956



 Score =  145 bits (365), Expect = 2e-34
 Identities = 63/143 (44%), Positives = 94/143 (65%)

Query: 731  LRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDK 790
            L+DC+ LF+  E L +++ +YC +C+  + + KK ++W LP +L+VHLKRFSY+  W+ K
Sbjct: 964  LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023

Query: 791  LDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYF 850
            L T V+FP+  L++S++V         Y+L +VSNHYG +  GHYTAY KN    +W+ F
Sbjct: 1024 LQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083

Query: 851  DDSNVSLASEDQIVTKAAYVLFY 873
            DD  VS  S   + + AAY+LFY
Sbjct: 1084 DDHEVSDISVSSVKSSAAYILFY 1106


>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  189 bits (480), Expect = 1e-47
 Identities = 90/183 (49%), Positives = 124/183 (67%)

Query: 252 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 311
           P L GL NLGNTC+MNS LQCL N   L DYF ++ Y+ +INR N LG KGE+AE +  +
Sbjct: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGII 833

Query: 312 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
           +K +W+G+  +++P+ FK  +G+   QF+GY QQDSQELL FL+DGLHEDLN+   +   
Sbjct: 834 MKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRY 893

Query: 372 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 431
           + ++ +   D   A+ AW+ H+  N+S+IV  F G FKST+ C  C K S TF+ F YL+
Sbjct: 894 KEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLS 953

Query: 432 LPL 434
           LPL
Sbjct: 954 LPL 956



 Score =  145 bits (365), Expect = 2e-34
 Identities = 63/143 (44%), Positives = 94/143 (65%)

Query: 731  LRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDK 790
            L+DC+ LF+  E L +++ +YC +C+  + + KK ++W LP +L+VHLKRFSY+  W+ K
Sbjct: 964  LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023

Query: 791  LDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYF 850
            L T V+FP+  L++S++V         Y+L +VSNHYG +  GHYTAY KN    +W+ F
Sbjct: 1024 LQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083

Query: 851  DDSNVSLASEDQIVTKAAYVLFY 873
            DD  VS  S   + + AAY+LFY
Sbjct: 1084 DDHEVSDISVSSVKSSAAYILFY 1106


>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  189 bits (480), Expect = 1e-47
 Identities = 90/183 (49%), Positives = 124/183 (67%)

Query: 252 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 311
           P L GL NLGNTC+MNS LQCL N   L DYF ++ Y+ +INR N LG KGE+AE +  +
Sbjct: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGII 833

Query: 312 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
           +K +W+G+  +++P+ FK  +G+   QF+GY QQDSQELL FL+DGLHEDLN+   +   
Sbjct: 834 MKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRY 893

Query: 372 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 431
           + ++ +   D   A+ AW+ H+  N+S+IV  F G FKST+ C  C K S TF+ F YL+
Sbjct: 894 KEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLS 953

Query: 432 LPL 434
           LPL
Sbjct: 954 LPL 956



 Score =  145 bits (365), Expect = 2e-34
 Identities = 63/143 (44%), Positives = 94/143 (65%)

Query: 731  LRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDK 790
            L+DC+ LF+  E L +++ +YC +C+  + + KK ++W LP +L+VHLKRFSY+  W+ K
Sbjct: 964  LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023

Query: 791  LDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYF 850
            L T V+FP+  L++S++V         Y+L +VSNHYG +  GHYTAY KN    +W+ F
Sbjct: 1024 LQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083

Query: 851  DDSNVSLASEDQIVTKAAYVLFY 873
            DD  VS  S   + + AAY+LFY
Sbjct: 1084 DDHEVSDISVSSVKSSAAYILFY 1106


>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
          Length = 1123

 Score =  167 bits (424), Expect = 3e-41
 Identities = 91/235 (38%), Positives = 128/235 (54%), Gaps = 28/235 (11%)

Query: 691 LAMDWDSETR-RLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDP 749
           LA++WDS  + RL+   QE  A +      Q Q  ++ +  L +C + +T  E L + D 
Sbjct: 501 LAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDA 560

Query: 750 WYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVC 809
           W CP+C+  QQ   K  LW+LP IL++HLKRF      R+KL T+V+FP+ GLNM+  V 
Sbjct: 561 WKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVA 620

Query: 810 NLSARP-----------------------YVYDLIAVSNHYGAMGVGHYTAYAKNKLNGK 846
             S  P                       ++YDL AV NH+G +  GHYTAY +N L+G+
Sbjct: 621 QRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQ 680

Query: 847 WYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSS 901
           WY +DDS V    ED++ T+ AY+LFYQ+R+      P  S+S S  G T  S S
Sbjct: 681 WYSYDDSTVEPLREDEVNTRGAYILFYQKRN----SIPPWSASSSMRGSTSSSLS 731



 Score =  148 bits (373), Expect = 3e-35
 Identities = 88/280 (31%), Positives = 140/280 (50%), Gaps = 14/280 (5%)

Query: 252 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 311
           PG  GL N GNTCFMN+ +QCLSNT  L ++     Y A   R        E+ E  A L
Sbjct: 98  PGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGR-------AEVTEQLAAL 150

Query: 312 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
           ++ +W+          FK  V ++  QF G  Q D+ E L +LLD +HEDL    + P  
Sbjct: 151 VRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVS 210

Query: 372 ELKDANGRPDAVVAKEAWENHRLR---NDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFC 428
           E       P+A    E   +   +     S +   F   ++S+L CP C K S TFDPF 
Sbjct: 211 EKLP----PEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFL 266

Query: 429 YLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVV 488
            ++LP+PL++ R + V LV      R  +  + VP++  V+ L + ++   G+ A+ +++
Sbjct: 267 CVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVIL 326

Query: 489 ADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGS 528
            ++Y   F + F  +E LN I   D+++ ++V  +   G+
Sbjct: 327 VELYPSGFQRSFFDEEDLNTIAEGDNVYAFQVPPSPSQGT 366


>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
          Length = 1352

 Score =  165 bits (417), Expect = 2e-40
 Identities = 92/233 (39%), Positives = 125/233 (53%), Gaps = 28/233 (12%)

Query: 691 LAMDWDSETRRLYYDEQESEAYE--KHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHD 748
           L ++WD ETR   +   E E     + V + + +  +  T  L  C +L+T  E L   D
Sbjct: 556 LVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDD 615

Query: 749 PWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFV 808
            W CP+CK+ QQ +    LW+LP +L++HLKRF      R KL  +V+FP+ GL+M+  V
Sbjct: 616 AWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHV 675

Query: 809 CNLSA-------------RPY---------VYDLIAVSNHYGAMGVGHYTAYAKNKLNGK 846
              S              RPY         +YDL AV NH+G M  GHYTAY KN ++G 
Sbjct: 676 VKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGL 735

Query: 847 WYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPS 899
           WY FDDS+V   SED++ T+ AY+LFYQRR       PS S++ S  G T  S
Sbjct: 736 WYCFDDSDVQQLSEDEVCTQTAYILFYQRRT----AIPSWSANSSVAGSTSSS 784



 Score =  150 bits (379), Expect = 5e-36
 Identities = 102/302 (33%), Positives = 144/302 (47%), Gaps = 35/302 (11%)

Query: 242 CQEPPSSHIQP--------GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEA--- 290
           C  PP+S   P        G+ GL N GNTCFMN+ LQCLSNT    +Y    +Y A   
Sbjct: 107 CPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRP 166

Query: 291 --EINRDNPLGM----KGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQ 344
               + + P G     +GE+ E  A L++ +W+        R FKT V + A Q+ G  Q
Sbjct: 167 EPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQ 226

Query: 345 QDSQELLAFLLDGLHEDLNRVKK-------KPYLELKDANGRPDAVVAKEAWENHRLRND 397
            D+QE L +LLD +HEDLN   K       KP  E       P   V             
Sbjct: 227 HDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMMPEGPSFPVC-----------S 275

Query: 398 SVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQ 457
           + + + F   ++S+L CP C K S TFDPF  ++LP+PL   R + V +V         +
Sbjct: 276 TFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMR 335

Query: 458 YRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFV 517
             V VPL G V+ L EA+S  + I  + +V+ ++Y   FH+ F   + L  +   D IF 
Sbjct: 336 IGVAVPLSGTVARLREAVSMETKIPTDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFA 395

Query: 518 YE 519
           +E
Sbjct: 396 FE 397


>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
           sapiens]
          Length = 605

 Score =  160 bits (405), Expect = 5e-39
 Identities = 91/215 (42%), Positives = 123/215 (57%), Gaps = 8/215 (3%)

Query: 226 RQTLQSNGSGFSASYNCQEPP-----SSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLT 280
           R TL   G G +   +    P     +S    GL GL NLGNTCFMNS LQCLSNT  L 
Sbjct: 233 RYTLWETGKGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELR 292

Query: 281 DYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMW-SGRDAHVAPRMFKTQVGRFAPQF 339
           DY L+  Y  +++  +       + E +A+LI+ +W S  +  V+P  FKTQ+ R+AP+F
Sbjct: 293 DYCLQRLYMRDLHHGS--NAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRF 350

Query: 340 SGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSV 399
            GY QQD+QE L FLLDGLH ++NRV  +P    ++ +  PD    ++ W  +  R DS 
Sbjct: 351 VGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSR 410

Query: 400 IVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPL 434
           I D F G  KS+L C +C   S  FDPF  L+LP+
Sbjct: 411 IGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI 445



 Score =  123 bits (309), Expect = 7e-28
 Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 1/152 (0%)

Query: 723 KKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFS 782
           K+    V L DC+ LFT  + L   +   C  C+  ++  KKF +   PKILV+HLKRFS
Sbjct: 447 KRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFS 506

Query: 783 YNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNK 842
            +R    KL T V FP+R L++ EF    +    VY+L AVSNH G    GHYTAY ++ 
Sbjct: 507 ESRIRTSKLTTFVNFPLRDLDLREFASE-NTNHAVYNLYAVSNHSGTTMGGHYTAYCRSP 565

Query: 843 LNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQ 874
             G+W+ F+DS+V+  S  Q+ T  AY+LFY+
Sbjct: 566 GTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 597


>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
          Length = 396

 Score =  158 bits (400), Expect = 2e-38
 Identities = 84/183 (45%), Positives = 113/183 (61%), Gaps = 3/183 (1%)

Query: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312
           GL GL NLGNTCFMNS LQCLSNT  L DY L+  Y  +++  +       + E +A+LI
Sbjct: 56  GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGS--NAHTALVEEFAKLI 113

Query: 313 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
           + +W S  +  V+P  FKTQ+ R+AP+F GY QQD+QE L FLLDGLH ++NRV  +P  
Sbjct: 114 QTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKS 173

Query: 372 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 431
             ++ +  PD    ++ W  +  R DS I D F G  KS+L C +C   S  FDPF  L+
Sbjct: 174 NPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLS 233

Query: 432 LPL 434
           LP+
Sbjct: 234 LPI 236



 Score =  123 bits (309), Expect = 7e-28
 Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 1/152 (0%)

Query: 723 KKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFS 782
           K+    V L DC+ LFT  + L   +   C  C+  ++  KKF +   PKILV+HLKRFS
Sbjct: 238 KRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFS 297

Query: 783 YNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNK 842
            +R    KL T V FP+R L++ EF    +    VY+L AVSNH G    GHYTAY ++ 
Sbjct: 298 ESRIRTSKLTTFVNFPLRDLDLREFASE-NTNHAVYNLYAVSNHSGTTMGGHYTAYCRSP 356

Query: 843 LNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQ 874
             G+W+ F+DS+V+  S  Q+ T  AY+LFY+
Sbjct: 357 GTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 388


>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
          Length = 520

 Score =  140 bits (354), Expect = 4e-33
 Identities = 70/148 (47%), Positives = 101/148 (68%), Gaps = 6/148 (4%)

Query: 730 ALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRD 789
           +LRDC+  FT +E L E + + C  CKK Q++TKKF +  LPK+L +HLKRF +  Y R+
Sbjct: 363 SLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRN 422

Query: 790 KLDTVVEFPIRGLNMSEFVC---NLSARPYVYDLIAVSNHYGA-MGVGHYTAYAKNKLNG 845
           K+DT VEFP+RGL+M  ++    N      +YDL AV  H+G+ +G GHYTAYA ++  G
Sbjct: 423 KVDTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHE--G 480

Query: 846 KWYYFDDSNVSLASEDQIVTKAAYVLFY 873
           +W++F+DS V+L  E+ +V   AY+LFY
Sbjct: 481 RWFHFNDSTVTLTDEETVVKAKAYILFY 508



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 71/260 (27%), Positives = 107/260 (41%), Gaps = 47/260 (18%)

Query: 193 EQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSNGSGFSASYNCQEPPSSHIQP 252
           E L  L+N+   A  ++ + L+     E+ T   + L+ NGS                  
Sbjct: 116 EHLQNLENSAFTADRHKKRKLL-----ENSTLNSKLLKVNGS----------------TT 154

Query: 253 GLC--GLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKG-------- 302
            +C  GL NLGNTCFMN+ LQ LSN      YF K+    E+      G +         
Sbjct: 155 AICATGLRNLGNTCFMNAILQSLSNIEQFCCYF-KELPAVELRNGKTAGRRTYHTRSQGD 213

Query: 303 ---EIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLH 359
               + E + + +  +W G     +P      V +  P F GYQQQD+ E + +LLD LH
Sbjct: 214 NNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLH 273

Query: 360 EDL----NRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCP 415
            +L    N V +   L+        +      A         +V+   F G+ ++ + C 
Sbjct: 274 LELQGGFNGVSRSAILQENSTLSASNKCCINGA--------STVVTAIFGGILQNEVNCL 325

Query: 416 ECAKVSVTFDPFCYLTLPLP 435
            C   S  FDPF  L+L +P
Sbjct: 326 ICGTESRKFDPFLDLSLDIP 345


>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score =  127 bits (320), Expect = 4e-29
 Identities = 77/201 (38%), Positives = 105/201 (52%), Gaps = 19/201 (9%)

Query: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312
           G  GL NLGNTCF+N+ LQCLS+T PL D+ L+ ++  E+      G   E+ EA+A++I
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266

Query: 313 KQMWSGRDAH-VAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKK--P 369
             +W       V P  F+    ++ P FSGY QQD+QE L  L++ LH ++NR  ++  P
Sbjct: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326

Query: 370 YLELKDANGRP-------------DAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPE 416
            L        P             D   A   W+ +  R DS IVD F G  KS L C  
Sbjct: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386

Query: 417 CAKVSVTFDPFCYLTLPLPLK 437
           C   S TF+ FC L+LP+P K
Sbjct: 387 CGYRSTTFEVFCDLSLPIPKK 407



 Score =  111 bits (277), Expect = 4e-24
 Identities = 58/146 (39%), Positives = 87/146 (59%), Gaps = 3/146 (2%)

Query: 729 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 788
           V+LRDC  LFT  E L   +   C  C++  ++TKK  +   P+ILV+HL RFS +R   
Sbjct: 414 VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473

Query: 789 DKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWY 848
            K    V+FP++ L++ +F  + +  P VY L A+ NH G++  GHYTA  + +    W+
Sbjct: 474 KKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHSGSVHYGHYTALCRCQTG--WH 530

Query: 849 YFDDSNVSLASEDQIVTKAAYVLFYQ 874
            ++DS VS  SE+Q+ +   YVLFYQ
Sbjct: 531 VYNDSRVSPVSENQVASSEGYVLFYQ 556


>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score =  127 bits (320), Expect = 4e-29
 Identities = 77/201 (38%), Positives = 105/201 (52%), Gaps = 19/201 (9%)

Query: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312
           G  GL NLGNTCF+N+ LQCLS+T PL D+ L+ ++  E+      G   E+ EA+A++I
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266

Query: 313 KQMWSGRDAH-VAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKK--P 369
             +W       V P  F+    ++ P FSGY QQD+QE L  L++ LH ++NR  ++  P
Sbjct: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326

Query: 370 YLELKDANGRP-------------DAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPE 416
            L        P             D   A   W+ +  R DS IVD F G  KS L C  
Sbjct: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386

Query: 417 CAKVSVTFDPFCYLTLPLPLK 437
           C   S TF+ FC L+LP+P K
Sbjct: 387 CGYRSTTFEVFCDLSLPIPKK 407



 Score =  111 bits (277), Expect = 4e-24
 Identities = 58/146 (39%), Positives = 87/146 (59%), Gaps = 3/146 (2%)

Query: 729 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 788
           V+LRDC  LFT  E L   +   C  C++  ++TKK  +   P+ILV+HL RFS +R   
Sbjct: 414 VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473

Query: 789 DKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWY 848
            K    V+FP++ L++ +F  + +  P VY L A+ NH G++  GHYTA  + +    W+
Sbjct: 474 KKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHSGSVHYGHYTALCRCQTG--WH 530

Query: 849 YFDDSNVSLASEDQIVTKAAYVLFYQ 874
            ++DS VS  SE+Q+ +   YVLFYQ
Sbjct: 531 VYNDSRVSPVSENQVASSEGYVLFYQ 556


>gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens]
          Length = 814

 Score =  127 bits (319), Expect = 5e-29
 Identities = 160/703 (22%), Positives = 275/703 (39%), Gaps = 164/703 (23%)

Query: 256 GLGNLGNTCFMNSALQCLSNTAPLTDYF--LKDE------YEAEINRDNPLGMK----GE 303
           G+ NLGNTCF N+ +Q L+ T  LTD    +K+       + +  ++ +PL ++    G 
Sbjct: 191 GITNLGNTCFFNAVMQNLAQTYTLTDLMNEIKESSTKLKIFPSSDSQLDPLVVELSRPGP 250

Query: 304 IAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLN 363
           +  A    +  M       ++P++   Q+ + AP+F  +QQQDSQELL +LLD +  +  
Sbjct: 251 LTSALFLFLHSMKETEKGPLSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEET 310

Query: 364 RVKKKPYLEL------KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPEC 417
           +  +   L+       K A+      V     E  ++   + I   F G   ST++C EC
Sbjct: 311 KRIQASILKAFNNPTTKTADDETRKKVKAYGKEGVKM---NFIDRIFIGELTSTVMCEEC 367

Query: 418 AKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEAL-- 475
           A +S   DPF  ++LP+                      + RV+ PL+    +   +L  
Sbjct: 368 ANISTVKDPFIDISLPI---------------------IEERVSKPLLWGRMNKYRSLRE 406

Query: 476 ---SRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVT 532
               R SG    N+ + +++  R  K         H             S+S D S+ + 
Sbjct: 407 TDHDRYSG----NVTIENIHQPRAAK--------KH-------------SSSKDKSQLI- 440

Query: 533 LPVYFRERKSRPSSTSSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEF 592
                 +RK     +S  +  Y +   L +    L   SL  +     SR  + P  D  
Sbjct: 441 -----HDRKCIRKLSSGETVTYQKNENLEMNGDSLMFASLMNSE----SRLNESPTDDS- 490

Query: 593 GSSPLEPGACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKG 652
                E  A +   N     +  E E   +       + GSG    G             
Sbjct: 491 -----EKEASHSESNVDADSEPSESESASKQTGLFRSSSGSGVQPDG-----------PL 534

Query: 653 QPCPKRLFTFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAY 712
            P       ++     G  ++    ++   L+L+S  T   D+D E + L          
Sbjct: 535 YPLSAGKLLYTKETDSGDKEMAEAISE---LRLSSTVTGDQDFDRENQPLNISNNLCFLE 591

Query: 713 EKHVSMLQPQKKKKTT----------VALRDCIELFTTMETLGEHDPWYCPNCKKHQQ-- 760
            KH+    PQ   +T            +++ C+  FT+ME L  ++   C NC K++Q  
Sbjct: 592 GKHLRSYSPQNAFQTLSQSYITTSKECSIQSCLYQFTSMELLMGNNKLLCENCTKNKQKY 651

Query: 761 -----------------ATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLN 803
                            A K+  + ++P +L++HLKRF        K++  V+FP+  L+
Sbjct: 652 QEETSFAEKKVEGVYTNARKQLLISAVPAVLILHLKRFHQAGLSLRKVNRHVDFPLM-LD 710

Query: 804 MSEFVCNLSAR------PYVYDLIAVSNHYGAMGVGHYTAYAK----------------- 840
           ++ F C+ + +        +Y L  +  H G+M  GHYTAY K                 
Sbjct: 711 LAPF-CSATCKNASVGDKVLYGLYGIVEHSGSMREGHYTAYVKVRTPSRKLSEHNTKKKN 769

Query: 841 --------NKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQR 875
                   N+  G+W +  D+ + +  E + ++  AY+LFY+R
Sbjct: 770 VPGLKAADNESAGQWVHVSDTYLQVVPESRALSAQAYLLFYER 812


>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
          Length = 828

 Score =  118 bits (295), Expect = 3e-26
 Identities = 59/155 (38%), Positives = 87/155 (56%), Gaps = 1/155 (0%)

Query: 729 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 788
           V L+DC+  F   + L   + + C  CKK +   K   + + P+IL +HLKRF +   + 
Sbjct: 559 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 618

Query: 789 DKLDTVVEFPIRGLNMSEFVCNLS-ARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 847
            K+ T V FP+ GL++  F+   S A+   YDL++V  H+G    GHY AY +N LN  W
Sbjct: 619 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW 678

Query: 848 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYK 882
           Y FDD +V+  SE  +    AYVLFY++  +E  K
Sbjct: 679 YEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQK 713



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 53/146 (36%), Positives = 79/146 (54%), Gaps = 14/146 (9%)

Query: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312
           GL GL N+GNTC+MN+ALQ LSN  PLT +FL     A  ++      K  I ++Y +L+
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK------KPAICKSYLKLM 236

Query: 313 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
            ++W   R   V P      +    P F GY QQD+QE L  L+D LHE+L    K+  +
Sbjct: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL----KEQVM 292

Query: 372 ELKDANGRPDAVVAKEAWENHRLRND 397
           E+++    P  +  +E  E  + ++D
Sbjct: 293 EVEE---DPQTITTEETMEEDKSQSD 315



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 20/42 (47%), Positives = 27/42 (64%)

Query: 398 SVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 439
           SVI D F G   S++ C  C +VSVT + F  L+LP+P K+D
Sbjct: 473 SVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514


>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
          Length = 942

 Score =  118 bits (295), Expect = 3e-26
 Identities = 59/155 (38%), Positives = 87/155 (56%), Gaps = 1/155 (0%)

Query: 729 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 788
           V L+DC+  F   + L   + + C  CKK +   K   + + P+IL +HLKRF +   + 
Sbjct: 567 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 626

Query: 789 DKLDTVVEFPIRGLNMSEFVCNLS-ARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 847
            K+ T V FP+ GL++  F+   S A+   YDL++V  H+G    GHY AY +N LN  W
Sbjct: 627 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW 686

Query: 848 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYK 882
           Y FDD +V+  SE  +    AYVLFY++  +E  K
Sbjct: 687 YEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQK 721



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 53/146 (36%), Positives = 79/146 (54%), Gaps = 14/146 (9%)

Query: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312
           GL GL N+GNTC+MN+ALQ LSN  PLT +FL     A  ++      K  I ++Y +L+
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK------KPAICKSYLKLM 236

Query: 313 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
            ++W   R   V P      +    P F GY QQD+QE L  L+D LHE+L    K+  +
Sbjct: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL----KEQVM 292

Query: 372 ELKDANGRPDAVVAKEAWENHRLRND 397
           E+++    P  +  +E  E  + ++D
Sbjct: 293 EVEE---DPQTITTEETMEEDKSQSD 315



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 20/42 (47%), Positives = 27/42 (64%)

Query: 398 SVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 439
           SVI D F G   S++ C  C +VSVT + F  L+LP+P K+D
Sbjct: 473 SVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 14/93 (15%)

Query: 32  AQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDEL 91
           A +Y I  +WF++W+ +V          G+    PGPIDN+ +        +   L    
Sbjct: 845 ATFYCISMQWFREWESFV---------KGKDGDPPGPIDNTKIAVTKCGNVM---LRQGA 892

Query: 92  DYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEH 124
           D   +  E WN L + YG   G + I+R  V H
Sbjct: 893 DSGQISEETWNFLQSIYG--GGPEVILRPPVVH 923


>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
          Length = 911

 Score =  118 bits (295), Expect = 3e-26
 Identities = 59/155 (38%), Positives = 87/155 (56%), Gaps = 1/155 (0%)

Query: 729 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 788
           V L+DC+  F   + L   + + C  CKK +   K   + + P+IL +HLKRF +   + 
Sbjct: 536 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 595

Query: 789 DKLDTVVEFPIRGLNMSEFVCNLS-ARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 847
            K+ T V FP+ GL++  F+   S A+   YDL++V  H+G    GHY AY +N LN  W
Sbjct: 596 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW 655

Query: 848 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYK 882
           Y FDD +V+  SE  +    AYVLFY++  +E  K
Sbjct: 656 YEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQK 690



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 53/146 (36%), Positives = 79/146 (54%), Gaps = 14/146 (9%)

Query: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312
           GL GL N+GNTC+MN+ALQ LSN  PLT +FL     A  ++      K  I ++Y +L+
Sbjct: 152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK------KPAICKSYLKLM 205

Query: 313 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
            ++W   R   V P      +    P F GY QQD+QE L  L+D LHE+L    K+  +
Sbjct: 206 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL----KEQVM 261

Query: 372 ELKDANGRPDAVVAKEAWENHRLRND 397
           E+++    P  +  +E  E  + ++D
Sbjct: 262 EVEE---DPQTITTEETMEEDKSQSD 284



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 20/42 (47%), Positives = 27/42 (64%)

Query: 398 SVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 439
           SVI D F G   S++ C  C +VSVT + F  L+LP+P K+D
Sbjct: 442 SVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 483



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 14/93 (15%)

Query: 32  AQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDEL 91
           A +Y I  +WF++W+ +V          G+    PGPIDN+ +        +   L    
Sbjct: 814 ATFYCISMQWFREWESFV---------KGKDGDPPGPIDNTKIAVTKCGNVM---LRQGA 861

Query: 92  DYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEH 124
           D   +  E WN L + YG   G + I+R  V H
Sbjct: 862 DSGQISEETWNFLQSIYG--GGPEVILRPPVVH 892


>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score =  112 bits (281), Expect = 1e-24
 Identities = 55/152 (36%), Positives = 86/152 (56%), Gaps = 1/152 (0%)

Query: 729 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 788
           V L DC+  F   + L   + + C  CKK +   K   +  LP+IL +HLKRF +   + 
Sbjct: 537 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596

Query: 789 DKLDTVVEFPIRGLNMSEFVCN-LSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 847
            K+++ V FP+ GL++  F+    +++   YDL++V  H+G  G GHY AY +N +NG+W
Sbjct: 597 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQW 656

Query: 848 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDE 879
           Y FDD  V+   E  +     YVLFY++  +E
Sbjct: 657 YEFDDQYVTEVHETVVQNAEGYVLFYRKSSEE 688



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 46/111 (41%), Positives = 65/111 (58%), Gaps = 7/111 (6%)

Query: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312
           GL G+ NLGN+C+MN+ALQ LSN  PLT +FL  E    +  D     K  + ++Y +L+
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL--ECGGLVRTDK----KPALCKSYQKLV 196

Query: 313 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDL 362
            ++W   R ++V P      +    P F GY QQD+QE L  L+D LHE+L
Sbjct: 197 SEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 11/75 (14%)

Query: 35  YLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYV 94
           Y I  +WF++W+ +V          G+ N  PGPIDNS +     S  ++  L    DY 
Sbjct: 818 YCISMQWFREWEAFVK---------GKDNEPPGPIDNSRIAQVKGSGHVQ--LKQGADYG 866

Query: 95  LVPTEAWNKLLNWYG 109
            +  E W  L + YG
Sbjct: 867 QISEETWTYLNSLYG 881



 Score = 37.4 bits (85), Expect = 0.065
 Identities = 20/45 (44%), Positives = 26/45 (57%)

Query: 395 RNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 439
           R  SVI D F G   S + C  C +VS T + F  L+LP+P K+D
Sbjct: 440 RYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKED 484


>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score =  112 bits (281), Expect = 1e-24
 Identities = 55/152 (36%), Positives = 86/152 (56%), Gaps = 1/152 (0%)

Query: 729 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 788
           V L DC+  F   + L   + + C  CKK +   K   +  LP+IL +HLKRF +   + 
Sbjct: 537 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596

Query: 789 DKLDTVVEFPIRGLNMSEFVCN-LSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 847
            K+++ V FP+ GL++  F+    +++   YDL++V  H+G  G GHY AY +N +NG+W
Sbjct: 597 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQW 656

Query: 848 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDE 879
           Y FDD  V+   E  +     YVLFY++  +E
Sbjct: 657 YEFDDQYVTEVHETVVQNAEGYVLFYRKSSEE 688



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 46/111 (41%), Positives = 65/111 (58%), Gaps = 7/111 (6%)

Query: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312
           GL G+ NLGN+C+MN+ALQ LSN  PLT +FL  E    +  D     K  + ++Y +L+
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL--ECGGLVRTDK----KPALCKSYQKLV 196

Query: 313 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDL 362
            ++W   R ++V P      +    P F GY QQD+QE L  L+D LHE+L
Sbjct: 197 SEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 11/75 (14%)

Query: 35  YLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYV 94
           Y I  +WF++W+ +V          G+ N  PGPIDNS +     S  ++  L    DY 
Sbjct: 818 YCISMQWFREWEAFVK---------GKDNEPPGPIDNSRIAQVKGSGHVQ--LKQGADYG 866

Query: 95  LVPTEAWNKLLNWYG 109
            +  E W  L + YG
Sbjct: 867 QISEETWTYLNSLYG 881



 Score = 37.4 bits (85), Expect = 0.065
 Identities = 20/45 (44%), Positives = 26/45 (57%)

Query: 395 RNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 439
           R  SVI D F G   S + C  C +VS T + F  L+LP+P K+D
Sbjct: 440 RYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKED 484


>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score =  112 bits (281), Expect = 1e-24
 Identities = 55/152 (36%), Positives = 86/152 (56%), Gaps = 1/152 (0%)

Query: 729 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 788
           V L DC+  F   + L   + + C  CKK +   K   +  LP+IL +HLKRF +   + 
Sbjct: 537 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596

Query: 789 DKLDTVVEFPIRGLNMSEFVCN-LSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 847
            K+++ V FP+ GL++  F+    +++   YDL++V  H+G  G GHY AY +N +NG+W
Sbjct: 597 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQW 656

Query: 848 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDE 879
           Y FDD  V+   E  +     YVLFY++  +E
Sbjct: 657 YEFDDQYVTEVHETVVQNAEGYVLFYRKSSEE 688



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 46/111 (41%), Positives = 65/111 (58%), Gaps = 7/111 (6%)

Query: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312
           GL G+ NLGN+C+MN+ALQ LSN  PLT +FL  E    +  D     K  + ++Y +L+
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL--ECGGLVRTDK----KPALCKSYQKLV 196

Query: 313 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDL 362
            ++W   R ++V P      +    P F GY QQD+QE L  L+D LHE+L
Sbjct: 197 SEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 11/75 (14%)

Query: 35  YLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYV 94
           Y I  +WF++W+ +V          G+ N  PGPIDNS +     S  ++  L    DY 
Sbjct: 818 YCISMQWFREWEAFVK---------GKDNEPPGPIDNSRIAQVKGSGHVQ--LKQGADYG 866

Query: 95  LVPTEAWNKLLNWYG 109
            +  E W  L + YG
Sbjct: 867 QISEETWTYLNSLYG 881



 Score = 37.4 bits (85), Expect = 0.065
 Identities = 20/45 (44%), Positives = 26/45 (57%)

Query: 395 RNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 439
           R  SVI D F G   S + C  C +VS T + F  L+LP+P K+D
Sbjct: 440 RYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKED 484


>gi|239751420 PREDICTED: similar to hCG2039376 [Homo sapiens]
          Length = 858

 Score =  100 bits (248), Expect = 8e-21
 Identities = 44/84 (52%), Positives = 61/84 (72%), Gaps = 2/84 (2%)

Query: 251 QPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAE 310
           + G  GL NLGNTCFMNS++QC+SNT PLT YF+   +  E+NR NP+GMKG +A+ Y +
Sbjct: 775 EKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGD 834

Query: 311 LIKQMWSGRDAHVAPRMFKTQVGR 334
           L++++WSG   +VAP   K +V R
Sbjct: 835 LVQELWSGTQKNVAP--LKLRVSR 856



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 13/29 (44%), Positives = 21/29 (72%)

Query: 25  RTTLQRGAQWYLIDSRWFKQWKKYVGFDS 53
           R  LQ G  W++I  +W++QWK+YV +D+
Sbjct: 455 RYGLQAGHNWFIISMQWWQQWKEYVKYDA 483



 Score = 31.6 bits (70), Expect = 3.5
 Identities = 20/55 (36%), Positives = 23/55 (41%), Gaps = 11/55 (20%)

Query: 66  PGPIDNSGLFSDP---------ESQTLKE--HLIDELDYVLVPTEAWNKLLNWYG 109
           PG IDN  L +           E   LK    LI   DY +VP   W  L +WYG
Sbjct: 589 PGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYG 643


>gi|45267835 ubiquitin specific protease 50 [Homo sapiens]
          Length = 339

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 61/189 (32%), Positives = 92/189 (48%), Gaps = 8/189 (4%)

Query: 249 HIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAY 308
           H Q G+ GL NLGNTC +N+  QCL +  PL +YFL  +Y   + +        E+A A+
Sbjct: 39  HFQ-GVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLPSDCSEVATAF 97

Query: 309 AELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKK 368
           A L+  MW G    V+P +F + +G   P F+   QQD+QE L  +L+ LHE L    KK
Sbjct: 98  AYLMTDMWLGDSDCVSPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEAL----KK 153

Query: 369 PYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFC 428
            +   + +  +         W        S+I   F      ++VC +C K +   + F 
Sbjct: 154 YHYSRRRSYEKGSTQRCCRKWIT---TETSIITQLFEEQLNYSIVCLKCEKCTYKNEVFT 210

Query: 429 YLTLPLPLK 437
             +LP+P K
Sbjct: 211 VFSLPIPSK 219



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 38/118 (32%), Positives = 68/118 (57%)

Query: 726 KTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNR 785
           K   +LRDC++ F   + L  ++  +C  C+  Q+   +  +   PKI++ HLKRF    
Sbjct: 219 KYECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQG 278

Query: 786 YWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKL 843
             + KL T + +P+  L+++ ++C++  +   Y+L AV NH+G +  GHYTA+ KN +
Sbjct: 279 TTKRKLRTDIHYPLTNLDLTPYICSIFRKYPKYNLCAVVNHFGDLDGGHYTAFCKNSV 336


>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
          Length = 822

 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 63/204 (30%), Positives = 100/204 (49%), Gaps = 14/204 (6%)

Query: 245 PPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNP------- 297
           P +S  Q  + GL NLGNTCF N+ +Q LS T  L +   + +    I +  P       
Sbjct: 185 PMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTE 244

Query: 298 -----LGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLA 352
                L   G +  A ++ + +M   +   V P+   +QV + A +F GYQQQDSQELL 
Sbjct: 245 PLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLR 304

Query: 353 FLLDGLH-EDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVD-TFHGLFKS 410
           +LLDG+  E+  RV K       ++  + D  +  +  +  + ++    VD  F G   S
Sbjct: 305 YLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTS 364

Query: 411 TLVCPECAKVSVTFDPFCYLTLPL 434
            ++C +C  VS+  + F  L+LP+
Sbjct: 365 MIMCDQCRTVSLVHESFLDLSLPV 388



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 48/192 (25%), Positives = 80/192 (41%), Gaps = 48/192 (25%)

Query: 730 ALRDCIELFTTMETLGEHDPWYCPNCKKHQ-----------------QATKKFDLWSLPK 772
           +++ C+  FT  E L + +   C  C + Q                  A K+  +   P 
Sbjct: 631 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 690

Query: 773 ILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPY-------VYDLIAVSN 825
           +L +HLKRF    +   K++  ++FP   L+++ F C L  +         +Y L  V  
Sbjct: 691 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPF-CTLKCKNVAEENTRVLYSLYGVVE 748

Query: 826 HYGAMGVGHYTAYAKNKL----------------------NGKWYYFDDSNVSLASEDQI 863
           H G M  GHYTAYAK +                        G+W++  D++V      ++
Sbjct: 749 HSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKV 808

Query: 864 VTKAAYVLFYQR 875
           +   AY+LFY+R
Sbjct: 809 LNSQAYLLFYER 820


>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
          Length = 823

 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 63/204 (30%), Positives = 100/204 (49%), Gaps = 14/204 (6%)

Query: 245 PPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNP------- 297
           P +S  Q  + GL NLGNTCF N+ +Q LS T  L +   + +    I +  P       
Sbjct: 186 PMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTE 245

Query: 298 -----LGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLA 352
                L   G +  A ++ + +M   +   V P+   +QV + A +F GYQQQDSQELL 
Sbjct: 246 PLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLR 305

Query: 353 FLLDGLH-EDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVD-TFHGLFKS 410
           +LLDG+  E+  RV K       ++  + D  +  +  +  + ++    VD  F G   S
Sbjct: 306 YLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTS 365

Query: 411 TLVCPECAKVSVTFDPFCYLTLPL 434
            ++C +C  VS+  + F  L+LP+
Sbjct: 366 MIMCDQCRTVSLVHESFLDLSLPV 389



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 48/192 (25%), Positives = 80/192 (41%), Gaps = 48/192 (25%)

Query: 730 ALRDCIELFTTMETLGEHDPWYCPNCKKHQ-----------------QATKKFDLWSLPK 772
           +++ C+  FT  E L + +   C  C + Q                  A K+  +   P 
Sbjct: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691

Query: 773 ILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPY-------VYDLIAVSN 825
           +L +HLKRF    +   K++  ++FP   L+++ F C L  +         +Y L  V  
Sbjct: 692 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPF-CTLKCKNVAEENTRVLYSLYGVVE 749

Query: 826 HYGAMGVGHYTAYAKNKL----------------------NGKWYYFDDSNVSLASEDQI 863
           H G M  GHYTAYAK +                        G+W++  D++V      ++
Sbjct: 750 HSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKV 809

Query: 864 VTKAAYVLFYQR 875
           +   AY+LFY+R
Sbjct: 810 LNSQAYLLFYER 821


>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
          Length = 823

 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 63/204 (30%), Positives = 100/204 (49%), Gaps = 14/204 (6%)

Query: 245 PPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNP------- 297
           P +S  Q  + GL NLGNTCF N+ +Q LS T  L +   + +    I +  P       
Sbjct: 186 PMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTE 245

Query: 298 -----LGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLA 352
                L   G +  A ++ + +M   +   V P+   +QV + A +F GYQQQDSQELL 
Sbjct: 246 PLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLR 305

Query: 353 FLLDGLH-EDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVD-TFHGLFKS 410
           +LLDG+  E+  RV K       ++  + D  +  +  +  + ++    VD  F G   S
Sbjct: 306 YLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTS 365

Query: 411 TLVCPECAKVSVTFDPFCYLTLPL 434
            ++C +C  VS+  + F  L+LP+
Sbjct: 366 MIMCDQCRTVSLVHESFLDLSLPV 389



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 48/192 (25%), Positives = 80/192 (41%), Gaps = 48/192 (25%)

Query: 730 ALRDCIELFTTMETLGEHDPWYCPNCKKHQ-----------------QATKKFDLWSLPK 772
           +++ C+  FT  E L + +   C  C + Q                  A K+  +   P 
Sbjct: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691

Query: 773 ILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPY-------VYDLIAVSN 825
           +L +HLKRF    +   K++  ++FP   L+++ F C L  +         +Y L  V  
Sbjct: 692 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPF-CTLKCKNVAEENTRVLYSLYGVVE 749

Query: 826 HYGAMGVGHYTAYAKNKL----------------------NGKWYYFDDSNVSLASEDQI 863
           H G M  GHYTAYAK +                        G+W++  D++V      ++
Sbjct: 750 HSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKV 809

Query: 864 VTKAAYVLFYQR 875
           +   AY+LFY+R
Sbjct: 810 LNSQAYLLFYER 821


>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
          Length = 525

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 51/168 (30%), Positives = 81/168 (48%), Gaps = 17/168 (10%)

Query: 728 TVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYW 787
           T  L DC+  FT  E LG      C  C  +Q++TK+  +  LP +   HLKRF ++   
Sbjct: 359 TTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKL 418

Query: 788 RDKLDTVVEFPIRGLNMSEFVCNLSA---------------RPYVYDLIAVSNHYGAMGV 832
           R K+ T V FP+  L+M+ F+ +                      Y L AV NH G +  
Sbjct: 419 RRKITTYVSFPLE-LDMTPFMASSKESRMNGQYQQPTDSLNNDNKYSLFAVVNHQGTLES 477

Query: 833 GHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEF 880
           GHYT++ +     +W+  DD+ ++ AS   ++    Y+LFY ++  E+
Sbjct: 478 GHYTSFIRQH-KDQWFKCDDAIITKASIKDVLDSEGYLLFYHKQFLEY 524



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 59/189 (31%), Positives = 85/189 (44%), Gaps = 24/189 (12%)

Query: 247 SSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAE 306
           +S+   GL GL NLGNTCFMN  +Q L++T  L D+FL D +  E+   +       +  
Sbjct: 168 TSNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSC-----LVC 222

Query: 307 AYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVK 366
             + L ++ +SG  +   P      V   A   +GY+QQD+ E L   LD LH       
Sbjct: 223 EMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCK--- 279

Query: 367 KKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDP 426
                   D NG+           N+    + +I   F G  +S + C  C  VS T DP
Sbjct: 280 -------GDDNGKK---------ANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDP 323

Query: 427 FCYLTLPLP 435
           F  ++L LP
Sbjct: 324 FWDISLDLP 332


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,570,342
Number of Sequences: 37866
Number of extensions: 1796733
Number of successful extensions: 9483
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 83
Number of HSP's that attempted gapping in prelim test: 7963
Number of HSP's gapped (non-prelim): 932
length of query: 916
length of database: 18,247,518
effective HSP length: 111
effective length of query: 805
effective length of database: 14,044,392
effective search space: 11305735560
effective search space used: 11305735560
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.