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Search of human proteins with 40795665
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40795665 ubiquitin specific protease 4 isoform a [Homo
sapiens]
(963 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens] 1986 0.0
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens] 1871 0.0
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 1097 0.0
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens] 785 0.0
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens] 399 e-111
gi|22550104 ubiquitin specific protease 32 [Homo sapiens] 276 5e-74
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 256 7e-68
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 189 1e-47
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 189 1e-47
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 189 1e-47
gi|148612811 ubiquitin specific protease 43 [Homo sapiens] 167 3e-41
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens] 165 2e-40
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 159 1e-38
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 158 2e-38
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 140 4e-33
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 127 4e-29
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 127 4e-29
gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens] 127 5e-29
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 118 3e-26
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens] 118 3e-26
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens] 118 3e-26
gi|183396780 ubiquitin specific protease 20 [Homo sapiens] 112 1e-24
gi|183397136 ubiquitin specific protease 20 [Homo sapiens] 112 1e-24
gi|183397134 ubiquitin specific protease 20 [Homo sapiens] 112 1e-24
gi|239751420 PREDICTED: similar to hCG2039376 [Homo sapiens] 100 9e-21
gi|45267835 ubiquitin specific protease 50 [Homo sapiens] 96 2e-19
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] 90 9e-18
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] 90 9e-18
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens] 90 9e-18
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 88 3e-17
>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
Length = 963
Score = 1986 bits (5144), Expect = 0.0
Identities = 963/963 (100%), Positives = 963/963 (100%)
Query: 1 MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG 60
MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG
Sbjct: 1 MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG 60
Query: 61 EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK 120
EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK
Sbjct: 61 EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK 120
Query: 121 VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE 180
VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE
Sbjct: 121 VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE 180
Query: 181 TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRN 240
TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRN
Sbjct: 181 TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRN 240
Query: 241 FTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPG 300
FTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPG
Sbjct: 241 FTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPG 300
Query: 301 LCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIK 360
LCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIK
Sbjct: 301 LCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIK 360
Query: 361 QMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL 420
QMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL
Sbjct: 361 QMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL 420
Query: 421 KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLP 480
KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLP
Sbjct: 421 KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLP 480
Query: 481 LPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN 540
LPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN
Sbjct: 481 LPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN 540
Query: 541 HRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASAL 600
HRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASAL
Sbjct: 541 HRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASAL 600
Query: 601 YGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGED 660
YGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGED
Sbjct: 601 YGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGED 660
Query: 661 EEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADI 720
EEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADI
Sbjct: 661 EEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADI 720
Query: 721 NSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRD 780
NSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRD
Sbjct: 721 NSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRD 780
Query: 781 CIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDT 840
CIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDT
Sbjct: 781 CIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDT 840
Query: 841 VVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDS 900
VVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDS
Sbjct: 841 VVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDS 900
Query: 901 NVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSM 960
NVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSM
Sbjct: 901 NVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSM 960
Query: 961 DTN 963
DTN
Sbjct: 961 DTN 963
>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
Length = 916
Score = 1871 bits (4847), Expect = 0.0
Identities = 915/963 (95%), Positives = 915/963 (95%), Gaps = 47/963 (4%)
Query: 1 MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG 60
MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG
Sbjct: 1 MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG 60
Query: 61 EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK 120
EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK
Sbjct: 61 EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK 120
Query: 121 VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE 180
VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE
Sbjct: 121 VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE 180
Query: 181 TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRN 240
TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQS
Sbjct: 181 TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSN-------- 232
Query: 241 FTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPG 300
GSGFSASYNCQEPPSSHIQPG
Sbjct: 233 ---------------------------------------GSGFSASYNCQEPPSSHIQPG 253
Query: 301 LCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIK 360
LCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIK
Sbjct: 254 LCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIK 313
Query: 361 QMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL 420
QMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL
Sbjct: 314 QMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL 373
Query: 421 KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLP 480
KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLP
Sbjct: 374 KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLP 433
Query: 481 LPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN 540
LPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN
Sbjct: 434 LPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN 493
Query: 541 HRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASAL 600
HRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASAL
Sbjct: 494 HRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASAL 553
Query: 601 YGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGED 660
YGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGED
Sbjct: 554 YGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGED 613
Query: 661 EEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADI 720
EEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADI
Sbjct: 614 EEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADI 673
Query: 721 NSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRD 780
NSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRD
Sbjct: 674 NSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRD 733
Query: 781 CIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDT 840
CIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDT
Sbjct: 734 CIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDT 793
Query: 841 VVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDS 900
VVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDS
Sbjct: 794 VVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDS 853
Query: 901 NVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSM 960
NVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSM
Sbjct: 854 NVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSM 913
Query: 961 DTN 963
DTN
Sbjct: 914 DTN 916
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 1097 bits (2836), Expect = 0.0
Identities = 559/950 (58%), Positives = 686/950 (72%), Gaps = 71/950 (7%)
Query: 1 MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG 60
MAEGG D +TQ+S++ L++T+L++G WYL+DSRWFKQWKKYVGFDSWD Y +G
Sbjct: 1 MAEGGAA----DLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMG 56
Query: 61 EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK 120
+ N++PGPIDNSGL D ++Q+LKEHLIDELDY+L+PTE WNKL++WY +EGQ+PI RK
Sbjct: 57 DQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWYTLMEGQEPIARK 116
Query: 121 VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE 180
VVE G+FVKHCKVEVYL ELKLCEN + NV++ FSKADTI TIEKE+RK+F+IP E+E
Sbjct: 117 VVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKE 176
Query: 181 TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRN 240
TRLWNKYMSNT+E L+K D+T+QDAGLYQGQVLVIE +NEDGTWPR PS
Sbjct: 177 TRLWNKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPR---------GPS-- 225
Query: 241 FTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPG 300
+P S Y S + N Y+ EP ++ QPG
Sbjct: 226 ---TPNVKNSNYCLPSYTAYKN------------------------YDYSEPGRNNEQPG 258
Query: 301 LCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIK 360
LCGL NLGNTCFMNSA+QCLSNT PLT+YFL D+Y+ E+N DNPLGM+GEIA++YAELIK
Sbjct: 259 LCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIK 318
Query: 361 QMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL 420
QMWSG+ ++V PR FKTQVGRFAPQFSGYQQQD QELLAFLLDGLHEDLNR++KKPY++L
Sbjct: 319 QMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQL 378
Query: 421 KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLP 480
KDA+GRPD VVA+EAWENH RNDS+IVD FHGLFKSTLVCPECAK+SVTFDPFCYLTLP
Sbjct: 379 KDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLP 438
Query: 481 LPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN 540
LP+KK+R +EV+LV DP +P QY+V VP +G + DLC ALS LSGI A+ M+V D+YN
Sbjct: 439 LPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYN 498
Query: 541 HRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSST-SSASA 599
HRFH+IF MDE L+ IM RDDI+V+E+ + +E V +PV RE+ S T + S+
Sbjct: 499 HRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVIIPVCLREKFRHSSYTHHTGSS 558
Query: 600 LYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLE-----------PGA 648
L+GQP L++VP++ T + LY + R+ RYVK E L P
Sbjct: 559 LFGQPFLMAVPRNN-TEDKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPNG 617
Query: 649 CNGSRNSCEGEDEEEMEHQEEGKEQLSETEGS-GEDEPGNDPSE----TTQKKIKGQPC- 702
+ + E E +E + + +E SE E S ED G D T+ KGQ
Sbjct: 618 IHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGGDNDSENGLCTEDTCKGQLTG 677
Query: 703 -PKRLFTFSLVNSYGTADIN-------SLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQ 754
KRLFTF N+ G DIN + D + L+L+ RS LA+DWD + ++ Y+DE
Sbjct: 678 HKKRLFTFQF-NNLGNTDINYIKDDTRHIRFDDRQLRLDERSFLALDWDPDLKKRYFDEN 736
Query: 755 ESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDL 814
+E +EKH S ++ + KK V L+DCIELFTT E LG DPWYCPNCK+HQQATKK DL
Sbjct: 737 AAEDFEKHES-VEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDL 795
Query: 815 WSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHY 874
WSLP +LVVHLKRFSY+RY RDKLDT+V+FPI L+MSEF+ N +A P Y+LIAVSNHY
Sbjct: 796 WSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHY 855
Query: 875 GAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRD 924
G MG GHYTA+AKNK +GKWYYFDDS+VS ASEDQIV+KAAYVLFYQR+D
Sbjct: 856 GGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQD 905
>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
Length = 963
Score = 785 bits (2027), Expect = 0.0
Identities = 437/950 (46%), Positives = 577/950 (60%), Gaps = 122/950 (12%)
Query: 28 LQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHL 87
L+ G W+L++ W+KQW+ YV D + FPG I+N+ LF D + LKE L
Sbjct: 96 LRAGESWFLVEKHWYKQWEAYVQGGDQDS------STFPGCINNATLFQDEINWRLKEGL 149
Query: 88 IDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEHGLFVKHCKVEVYLLELKLCENSD 147
++ DYVL+P AW+ L++WYG GQ PI RKV+E KVEVY +EL L ++D
Sbjct: 150 VEGEDYVLLPAAAWHYLVSWYGLEHGQPPIERKVIE---LPNIQKVEVYPVELLLVRHND 206
Query: 148 PTNVLSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTVQDAGL 207
+ FS D+I + + R+ F + + +TRLW K + ++L TV DA L
Sbjct: 207 LGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDAAL 266
Query: 208 YQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSPKSSASPYSSVSASLIANGDSTS 267
GQ++++E + +DGTWP SA L ++ S
Sbjct: 267 ETGQLIIMETRKKDGTWP------------------------------SAQLHVMNNNMS 296
Query: 268 TCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLT 327
+E QPG+CGL NLGNTCFMNSALQCLSN LT
Sbjct: 297 ----------------------EEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLT 334
Query: 328 DYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFS 387
+YFL + Y E+N NPLGMKGEIAEAYA+L+KQ WSG + P +FK +VG FA QF
Sbjct: 335 EYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFL 394
Query: 388 GYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVI 447
GYQQ DSQELL+FLLDGLHEDLNRVKKK Y+EL DA GRPD VA+EAW+NH+ RNDSVI
Sbjct: 395 GYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVI 454
Query: 448 VDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRV 507
VDTFHGLFKSTLVCP+C VSVTFDPFCYL++PLP+ RV+EVF +P DP +P Q+R+
Sbjct: 455 VDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRL 514
Query: 508 TVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEV 567
VP G +SDLC ALS+ +GI+ E M+VADV++HRF+K++Q++E L+ I+ RDDIFVYEV
Sbjct: 515 VVPKKGKISDLCVALSKHTGISPERMMVADVFSHRFYKLYQLEEPLSSILDRDDIFVYEV 574
Query: 568 CS--TSVDGS-ECVTLPVYFRERKSRPSSTSS--ASALYGQPLLLSVPKHKLTLESLYQA 622
+++GS E + +PVY RER +S L+G PLL+SVP+ + T E LY
Sbjct: 575 SGRIEAIEGSREDIVVPVYLRERTPARDYNNSYYGLMLFGHPLLVSVPRDRFTWEGLYNV 634
Query: 623 VCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGEDEEEMEHQEEGKEQL--SETEGS 680
+ R+SRYV +P NS + +D +E E EE K+ + T GS
Sbjct: 635 LMYRLSRYVTKP-------------------NSDDEDDGDEKEDDEEDKDDVPGPSTGGS 675
Query: 681 GEDEPGNDPSETTQKKIKGQPCP------------------KRLFTFSLVNSYGTADINS 722
D +P + CP K+LFT VNS GT+D +
Sbjct: 676 LRDP---EPEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTLQTVNSNGTSDRTT 732
Query: 723 LAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCI 782
+ ++++ +A+DW+ E ++ YYDE E+E Y KH + KK V L++CI
Sbjct: 733 SPEE-----VHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCV--GYVMKKAPVRLQECI 785
Query: 783 ELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVV 842
ELFTT+ETL + +PWYCP+CK+HQ ATKK DLW LP+IL++HLKRFSY ++ R+KLDT+V
Sbjct: 786 ELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLV 845
Query: 843 EFPIRGLNMSEFVC----NLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFD 898
EFPIR L+ SEFV + Y YDLIAVSNHYG M GHYT +A NK +G+W+YFD
Sbjct: 846 EFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFD 905
Query: 899 DSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSS 948
D++VS +E+QI +KAAYVLFYQR+D LS +GSS P+ S
Sbjct: 906 DNSVSPVNENQIESKAAYVLFYQRQD---VARRLLSPAGSSGAPASPACS 952
>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
Length = 1318
Score = 399 bits (1024), Expect = e-111
Identities = 266/739 (35%), Positives = 370/739 (50%), Gaps = 106/739 (14%)
Query: 299 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 358
PG GL NLGNTCFMNS +Q LSNT L D+F +EAEIN +NPLG G +A +A L
Sbjct: 494 PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVL 553
Query: 359 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
++ +W G P K V A QF+GY Q D+QE +AFLLDGLHEDLNR++ KPY
Sbjct: 554 LRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYT 613
Query: 419 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 478
E D++GRPD VVA+EAW+ H++RNDS IVD F G +KS LVCP CAKVS+TFDPF YL
Sbjct: 614 ETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLP 673
Query: 479 LPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGA-VSDLCEALSRLSGIAAENMVVAD 537
+PLP +K +V+ VF +PH +P ++ V+V + S++ ++LS+ + EN+ +A+
Sbjct: 674 VPLP-QKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAE 732
Query: 538 VYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVY-------------- 583
V +RFH++F L+ + P D + +E+ S+ + V L V
Sbjct: 733 VIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCA 792
Query: 584 --FRERKSRPSSTSSASALY--------------------------GQPLLLSVPKHKLT 615
R+++S + Y G P L+SVP +LT
Sbjct: 793 ACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLT 852
Query: 616 LESLYQAV--CDRISRYVKQPLPDEFGSSPLE---PGACN-GSRNSCEGEDEEE------ 663
L Q + R S V QP P + G LE PG S S E D E
Sbjct: 853 YARLAQLLEGYARYSVSVFQP-PFQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPP 911
Query: 664 ----MEHQEEGKEQL-------------------SETEGSGEDEPGNDPS----ETTQKK 696
+ EG L SE SG E G+ P+ +
Sbjct: 912 ELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAA 971
Query: 697 IKGQPCPKRLFTFSLVNSYGTADINSLAADGKL-------LKLNSRSTLAMDWDSETRR- 748
+ G P + + I+S + +L L+L +LA+ W + R
Sbjct: 972 VPGYQHPSEAMN-AHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQ 1030
Query: 749 --LYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQ 806
+ +E E E S + + T L C+ LFT E L + WYCP CK+H+
Sbjct: 1031 EFVLVASKELECAEDPGSAGEAARAGHFT--LDQCLNLFTRPEVLAPEEAWYCPQCKQHR 1088
Query: 807 QATKKFDLWSLPKILVVHLKRFSYNRY-WRDKLDTVVEFPIRGLNMSEFVCNLSARPY-V 864
+A+K+ LW LP +L+V LKRFS+ + WRDK++ +VEFP+R L++S+F
Sbjct: 1089 EASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPS 1148
Query: 865 YDLIAVSNHYGAMGVGHYTAYAK-------NKLNGKWYYFDDSNVSLASEDQIVTKAAYV 917
YDL AV NHYG M GHYTA A+ + + W FDDS V+ E Q+VT+ AYV
Sbjct: 1149 YDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYV 1208
Query: 918 LFYQRRDDEFYKTPSLSSS 936
LFY+RR+ + P S
Sbjct: 1209 LFYRRRNSPVERPPRAGHS 1227
>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
Length = 1604
Score = 276 bits (707), Expect = 5e-74
Identities = 177/510 (34%), Positives = 262/510 (51%), Gaps = 96/510 (18%)
Query: 66 PGPIDNSGLFSDP---------ESQTLKE--HLIDELDYVLVPTEAWNKLLNWYGC-VEG 113
PG IDN L + E LK LI DY +VP W L +WYG +
Sbjct: 521 PGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLAL 580
Query: 114 QQPIVRK----VVEHGLFVKHCKVEVYLLELKLCENSDPTNV------------------ 151
+P+++ + E LF ++ + L + + +N+
Sbjct: 581 PRPVIKNSKTDIPELELFPRY----LLFLRQQPATRTQQSNIWVNMGNVPSPNAPLKRVL 636
Query: 152 --LSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTVQDAGLYQ 209
C FS+ TI I + + + I E + RLW N L D+ ++ +
Sbjct: 637 AYTGC-FSRMQTIKEIHEYLSQRLRIK-EEDMRLWLYNSENYLTLLDDEDHKLEYLKIQD 694
Query: 210 GQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSPKSSASPYSSVSASLIANGDSTSTC 269
Q LVIE +N+D +WP + S IAN
Sbjct: 695 EQHLVIEVRNKDMSWPEEM-----------------------------SFIAN------- 718
Query: 270 GMHSSGVSRGGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDY 329
SS + R + P+ + G GL NLGNTCFMNS++QC+SNT PLT Y
Sbjct: 719 ---SSKIDR-----------HKVPT---EKGATGLSNLGNTCFMNSSIQCVSNTQPLTQY 761
Query: 330 FLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGY 389
F+ + E+NR NP+GMKG +A+ Y +L++++WSG +VAP + + ++AP+F+G+
Sbjct: 762 FISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGF 821
Query: 390 QQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVD 449
QQQDSQELLAFLLDGLHEDLNRV +KPY+ELKD++GRPD VA EAW+NH RN S++VD
Sbjct: 822 QQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVD 881
Query: 450 TFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTV 509
FHG +S + C C +SV FDPF +L+LPLP+ +E+ ++ D P +Y + +
Sbjct: 882 LFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLD-GTTPVRYGLRL 940
Query: 510 PLMGAVSDLCEALSRLSGIAAENMVVADVY 539
+ + L + LS L G+ +E +++A+V+
Sbjct: 941 NMDEKYTGLKKQLSDLCGLNSEQILLAEVH 970
Score = 95.1 bits (235), Expect = 3e-19
Identities = 46/119 (38%), Positives = 68/119 (57%), Gaps = 2/119 (1%)
Query: 738 LAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPW 797
+A+DWD L Y + ++H S+ Q ++ + + L C+ FT+ E LGE++ +
Sbjct: 1195 IAVDWDPTALHLRYQTSQERVVDEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEMY 1254
Query: 798 YCPNCKKHQQATKKFDLWSLPKILVVHLKRFSY-NRYWRDKLDTVVEFPIRGLNMSEFV 855
YC CK H ATKK DLW LP IL++HLKRF + N W K +V+FP + S F+
Sbjct: 1255 YCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW-IKSQKIVKFPRESFDPSAFL 1312
Score = 62.4 bits (150), Expect = 2e-09
Identities = 28/64 (43%), Positives = 43/64 (67%), Gaps = 1/64 (1%)
Query: 864 VYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRR 923
+Y+L A+S H G +G GHY YAKN N KWY ++DS+ D+I T +AY+LFY+++
Sbjct: 1509 IYNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQ 1567
Query: 924 DDEF 927
++
Sbjct: 1568 GIDY 1571
Score = 38.1 bits (87), Expect = 0.040
Identities = 13/29 (44%), Positives = 21/29 (72%)
Query: 25 RTTLQRGAQWYLIDSRWFKQWKKYVGFDS 53
R LQ G W++I +W++QWK+YV +D+
Sbjct: 387 RYGLQAGHNWFIISMQWWQQWKEYVKYDA 415
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 256 bits (654), Expect = 7e-68
Identities = 120/243 (49%), Positives = 171/243 (70%), Gaps = 1/243 (0%)
Query: 298 QPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAE 357
+ G GL NLGNTCFMNS++QC+SNT PLT YF+ + E+NR NP+GMKG +A+ Y +
Sbjct: 528 EKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGD 587
Query: 358 LIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPY 417
L++++WSG VAP + + ++AP+F G+QQQDSQELLAFLLDGLHEDLNRV +KPY
Sbjct: 588 LVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPY 647
Query: 418 LELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 477
+ELKD++GRPD VA EAW+NH RN S+IVD FHG +S + C C +SV FDPF +L
Sbjct: 648 VELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFL 707
Query: 478 TLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVAD 537
+LPLP+ +E+ ++ D P +Y + + + + L + L L G+ +E +++A+
Sbjct: 708 SLPLPMDSYMDLEITVIKLD-GTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAE 766
Query: 538 VYN 540
V++
Sbjct: 767 VHD 769
Score = 87.8 bits (216), Expect = 4e-17
Identities = 44/119 (36%), Positives = 63/119 (52%), Gaps = 2/119 (1%)
Query: 738 LAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPW 797
+A+DW L Y + +KH S+ Q ++ + + L C+ FT+ E LGE + +
Sbjct: 993 IAVDWHPTALHLRYQTSQERVVDKHESVEQSRRAQAEPINLDSCLRAFTSEEELGESEMY 1052
Query: 798 YCPNCKKHQQATKKFDLWSLPKILVVHLKRFSY-NRYWRDKLDTVVEFPIRGLNMSEFV 855
YC CK H ATKK DLW LP L++HLKRF + N W K +V F + S F+
Sbjct: 1053 YCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQW-IKSQKIVRFLRESFDPSAFL 1110
Score = 61.2 bits (147), Expect = 4e-09
Identities = 30/90 (33%), Positives = 51/90 (56%), Gaps = 2/90 (2%)
Query: 864 VYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRR 923
+Y+L A+S H G + GHY YAKN N KWY ++DS+ D+I T +AY+LFY+++
Sbjct: 1311 IYNLYAISCHSGILSGGHYITYAKNP-NCKWYCYNDSSCEELHPDEIDTDSAYILFYEQQ 1369
Query: 924 DDEFYK-TPSLSSSGSSDGGTRPSSSQQGF 952
++ + P + +D + S+ +
Sbjct: 1370 GIDYAQFLPKIDGKKMADTSSTDEDSESDY 1399
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 189 bits (480), Expect = 1e-47
Identities = 90/183 (49%), Positives = 124/183 (67%)
Query: 299 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 358
P L GL NLGNTC+MNS LQCL N L DYF ++ Y+ +INR N LG KGE+AE + +
Sbjct: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGII 833
Query: 359 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
+K +W+G+ +++P+ FK +G+ QF+GY QQDSQELL FL+DGLHEDLN+ +
Sbjct: 834 MKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRY 893
Query: 419 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 478
+ ++ + D A+ AW+ H+ N+S+IV F G FKST+ C C K S TF+ F YL+
Sbjct: 894 KEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLS 953
Query: 479 LPL 481
LPL
Sbjct: 954 LPL 956
Score = 145 bits (365), Expect = 2e-34
Identities = 63/143 (44%), Positives = 94/143 (65%)
Query: 778 LRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDK 837
L+DC+ LF+ E L +++ +YC +C+ + + KK ++W LP +L+VHLKRFSY+ W+ K
Sbjct: 964 LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023
Query: 838 LDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYF 897
L T V+FP+ L++S++V Y+L +VSNHYG + GHYTAY KN +W+ F
Sbjct: 1024 LQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083
Query: 898 DDSNVSLASEDQIVTKAAYVLFY 920
DD VS S + + AAY+LFY
Sbjct: 1084 DDHEVSDISVSSVKSSAAYILFY 1106
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 189 bits (480), Expect = 1e-47
Identities = 90/183 (49%), Positives = 124/183 (67%)
Query: 299 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 358
P L GL NLGNTC+MNS LQCL N L DYF ++ Y+ +INR N LG KGE+AE + +
Sbjct: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGII 833
Query: 359 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
+K +W+G+ +++P+ FK +G+ QF+GY QQDSQELL FL+DGLHEDLN+ +
Sbjct: 834 MKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRY 893
Query: 419 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 478
+ ++ + D A+ AW+ H+ N+S+IV F G FKST+ C C K S TF+ F YL+
Sbjct: 894 KEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLS 953
Query: 479 LPL 481
LPL
Sbjct: 954 LPL 956
Score = 145 bits (365), Expect = 2e-34
Identities = 63/143 (44%), Positives = 94/143 (65%)
Query: 778 LRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDK 837
L+DC+ LF+ E L +++ +YC +C+ + + KK ++W LP +L+VHLKRFSY+ W+ K
Sbjct: 964 LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023
Query: 838 LDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYF 897
L T V+FP+ L++S++V Y+L +VSNHYG + GHYTAY KN +W+ F
Sbjct: 1024 LQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083
Query: 898 DDSNVSLASEDQIVTKAAYVLFY 920
DD VS S + + AAY+LFY
Sbjct: 1084 DDHEVSDISVSSVKSSAAYILFY 1106
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 189 bits (480), Expect = 1e-47
Identities = 90/183 (49%), Positives = 124/183 (67%)
Query: 299 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 358
P L GL NLGNTC+MNS LQCL N L DYF ++ Y+ +INR N LG KGE+AE + +
Sbjct: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGII 833
Query: 359 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
+K +W+G+ +++P+ FK +G+ QF+GY QQDSQELL FL+DGLHEDLN+ +
Sbjct: 834 MKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRY 893
Query: 419 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 478
+ ++ + D A+ AW+ H+ N+S+IV F G FKST+ C C K S TF+ F YL+
Sbjct: 894 KEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLS 953
Query: 479 LPL 481
LPL
Sbjct: 954 LPL 956
Score = 145 bits (365), Expect = 2e-34
Identities = 63/143 (44%), Positives = 94/143 (65%)
Query: 778 LRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDK 837
L+DC+ LF+ E L +++ +YC +C+ + + KK ++W LP +L+VHLKRFSY+ W+ K
Sbjct: 964 LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023
Query: 838 LDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYF 897
L T V+FP+ L++S++V Y+L +VSNHYG + GHYTAY KN +W+ F
Sbjct: 1024 LQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083
Query: 898 DDSNVSLASEDQIVTKAAYVLFY 920
DD VS S + + AAY+LFY
Sbjct: 1084 DDHEVSDISVSSVKSSAAYILFY 1106
>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
Length = 1123
Score = 167 bits (424), Expect = 3e-41
Identities = 91/235 (38%), Positives = 128/235 (54%), Gaps = 28/235 (11%)
Query: 738 LAMDWDSETR-RLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDP 796
LA++WDS + RL+ QE A + Q Q ++ + L +C + +T E L + D
Sbjct: 501 LAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDA 560
Query: 797 WYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVC 856
W CP+C+ QQ K LW+LP IL++HLKRF R+KL T+V+FP+ GLNM+ V
Sbjct: 561 WKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVA 620
Query: 857 NLSARP-----------------------YVYDLIAVSNHYGAMGVGHYTAYAKNKLNGK 893
S P ++YDL AV NH+G + GHYTAY +N L+G+
Sbjct: 621 QRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQ 680
Query: 894 WYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSS 948
WY +DDS V ED++ T+ AY+LFYQ+R+ P S+S S G T S S
Sbjct: 681 WYSYDDSTVEPLREDEVNTRGAYILFYQKRN----SIPPWSASSSMRGSTSSSLS 731
Score = 148 bits (373), Expect = 3e-35
Identities = 88/280 (31%), Positives = 140/280 (50%), Gaps = 14/280 (5%)
Query: 299 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 358
PG GL N GNTCFMN+ +QCLSNT L ++ Y A R E+ E A L
Sbjct: 98 PGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGR-------AEVTEQLAAL 150
Query: 359 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
++ +W+ FK V ++ QF G Q D+ E L +LLD +HEDL + P
Sbjct: 151 VRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVS 210
Query: 419 ELKDANGRPDAVVAKEAWENHRLR---NDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFC 475
E P+A E + + S + F ++S+L CP C K S TFDPF
Sbjct: 211 EKLP----PEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFL 266
Query: 476 YLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVV 535
++LP+PL++ R + V LV R + + VP++ V+ L + ++ G+ A+ +++
Sbjct: 267 CVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVIL 326
Query: 536 ADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGS 575
++Y F + F +E LN I D+++ ++V + G+
Sbjct: 327 VELYPSGFQRSFFDEEDLNTIAEGDNVYAFQVPPSPSQGT 366
>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
Length = 1352
Score = 165 bits (417), Expect = 2e-40
Identities = 92/233 (39%), Positives = 125/233 (53%), Gaps = 28/233 (12%)
Query: 738 LAMDWDSETRRLYYDEQESEAYE--KHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHD 795
L ++WD ETR + E E + V + + + + T L C +L+T E L D
Sbjct: 556 LVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDD 615
Query: 796 PWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFV 855
W CP+CK+ QQ + LW+LP +L++HLKRF R KL +V+FP+ GL+M+ V
Sbjct: 616 AWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHV 675
Query: 856 CNLSA-------------RPY---------VYDLIAVSNHYGAMGVGHYTAYAKNKLNGK 893
S RPY +YDL AV NH+G M GHYTAY KN ++G
Sbjct: 676 VKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGL 735
Query: 894 WYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPS 946
WY FDDS+V SED++ T+ AY+LFYQRR PS S++ S G T S
Sbjct: 736 WYCFDDSDVQQLSEDEVCTQTAYILFYQRRT----AIPSWSANSSVAGSTSSS 784
Score = 152 bits (384), Expect = 1e-36
Identities = 114/366 (31%), Positives = 167/366 (45%), Gaps = 44/366 (12%)
Query: 234 STAPSRNFTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGG------SGFSASY 287
++ P+ + S SSA S + ++ + S + RGG G +A+
Sbjct: 43 ASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGLRSCFPPGPAAAP 102
Query: 288 N---CQEPPSSHIQP--------GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYE 336
C PP+S P G+ GL N GNTCFMN+ LQCLSNT +Y +Y
Sbjct: 103 TPPPCPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYR 162
Query: 337 A-----EINRDNPLGM----KGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFS 387
A + + P G +GE+ E A L++ +W+ R FKT V + A Q+
Sbjct: 163 AGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYR 222
Query: 388 GYQQQDSQELLAFLLDGLHEDLNRVKK-------KPYLELKDANGRPDAVVAKEAWENHR 440
G Q D+QE L +LLD +HEDLN K KP E P V
Sbjct: 223 GNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMMPEGPSFPVC-------- 274
Query: 441 LRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHC 500
+ + + F ++S+L CP C K S TFDPF ++LP+PL R + V +V
Sbjct: 275 ---STFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCS 331
Query: 501 RPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRD 560
+ V VPL G V+ L EA+S + I + +V+ ++Y FH+ F + L + D
Sbjct: 332 HCMRIGVAVPLSGTVARLREAVSMETKIPTDQIVLTEMYYDGFHRSFCDTDDLETVHESD 391
Query: 561 DIFVYE 566
IF +E
Sbjct: 392 CIFAFE 397
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 159 bits (402), Expect = 1e-38
Identities = 117/356 (32%), Positives = 166/356 (46%), Gaps = 34/356 (9%)
Query: 128 VKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKY 187
+ + + Y + L + D + L+ FS T + + R L P TR
Sbjct: 122 LSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTR----- 176
Query: 188 MSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSPKS 247
++L L Q A + V +E G+ Q S PSR P+
Sbjct: 177 -----KELCTLQGLYQTASCPEYLVDYLENYGRKGS----ASQVPSQAPPSR----VPEI 223
Query: 248 SASPYSSVSA-SLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPGLCGLGN 306
+ Y + +L G + SS R G +S GL GL N
Sbjct: 224 ISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGM------------NSKSAQGLAGLRN 271
Query: 307 LGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMW-SG 365
LGNTCFMNS LQCLSNT L DY L+ Y +++ + + E +A+LI+ +W S
Sbjct: 272 LGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGS--NAHTALVEEFAKLIQTIWTSS 329
Query: 366 RDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANG 425
+ V+P FKTQ+ R+AP+F GY QQD+QE L FLLDGLH ++NRV +P ++ +
Sbjct: 330 PNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDH 389
Query: 426 RPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPL 481
PD ++ W + R DS I D F G KS+L C +C S FDPF L+LP+
Sbjct: 390 LPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI 445
Score = 123 bits (309), Expect = 7e-28
Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 1/152 (0%)
Query: 770 KKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFS 829
K+ V L DC+ LFT + L + C C+ ++ KKF + PKILV+HLKRFS
Sbjct: 447 KRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFS 506
Query: 830 YNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNK 889
+R KL T V FP+R L++ EF + VY+L AVSNH G GHYTAY ++
Sbjct: 507 ESRIRTSKLTTFVNFPLRDLDLREFASE-NTNHAVYNLYAVSNHSGTTMGGHYTAYCRSP 565
Query: 890 LNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQ 921
G+W+ F+DS+V+ S Q+ T AY+LFY+
Sbjct: 566 GTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 597
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 158 bits (400), Expect = 2e-38
Identities = 84/183 (45%), Positives = 113/183 (61%), Gaps = 3/183 (1%)
Query: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359
GL GL NLGNTCFMNS LQCLSNT L DY L+ Y +++ + + E +A+LI
Sbjct: 56 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGS--NAHTALVEEFAKLI 113
Query: 360 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
+ +W S + V+P FKTQ+ R+AP+F GY QQD+QE L FLLDGLH ++NRV +P
Sbjct: 114 QTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKS 173
Query: 419 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 478
++ + PD ++ W + R DS I D F G KS+L C +C S FDPF L+
Sbjct: 174 NPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLS 233
Query: 479 LPL 481
LP+
Sbjct: 234 LPI 236
Score = 123 bits (309), Expect = 7e-28
Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 1/152 (0%)
Query: 770 KKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFS 829
K+ V L DC+ LFT + L + C C+ ++ KKF + PKILV+HLKRFS
Sbjct: 238 KRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFS 297
Query: 830 YNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNK 889
+R KL T V FP+R L++ EF + VY+L AVSNH G GHYTAY ++
Sbjct: 298 ESRIRTSKLTTFVNFPLRDLDLREFASE-NTNHAVYNLYAVSNHSGTTMGGHYTAYCRSP 356
Query: 890 LNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQ 921
G+W+ F+DS+V+ S Q+ T AY+LFY+
Sbjct: 357 GTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 388
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 140 bits (354), Expect = 4e-33
Identities = 70/148 (47%), Positives = 101/148 (68%), Gaps = 6/148 (4%)
Query: 777 ALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRD 836
+LRDC+ FT +E L E + + C CKK Q++TKKF + LPK+L +HLKRF + Y R+
Sbjct: 363 SLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRN 422
Query: 837 KLDTVVEFPIRGLNMSEFVC---NLSARPYVYDLIAVSNHYGA-MGVGHYTAYAKNKLNG 892
K+DT VEFP+RGL+M ++ N +YDL AV H+G+ +G GHYTAYA ++ G
Sbjct: 423 KVDTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHE--G 480
Query: 893 KWYYFDDSNVSLASEDQIVTKAAYVLFY 920
+W++F+DS V+L E+ +V AY+LFY
Sbjct: 481 RWFHFNDSTVTLTDEETVVKAKAYILFY 508
Score = 83.6 bits (205), Expect = 8e-16
Identities = 58/195 (29%), Positives = 84/195 (43%), Gaps = 24/195 (12%)
Query: 303 GLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKG-----------EI 351
GL NLGNTCFMN+ LQ LSN YF K+ E+ G + +
Sbjct: 160 GLRNLGNTCFMNAILQSLSNIEQFCCYF-KELPAVELRNGKTAGRRTYHTRSQGDNNVSL 218
Query: 352 AEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDL-- 409
E + + + +W G +P V + P F GYQQQD+ E + +LLD LH +L
Sbjct: 219 VEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQG 278
Query: 410 --NRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKV 467
N V + L+ + A +V+ F G+ ++ + C C
Sbjct: 279 GFNGVSRSAILQENSTLSASNKCCINGA--------STVVTAIFGGILQNEVNCLICGTE 330
Query: 468 SVTFDPFCYLTLPLP 482
S FDPF L+L +P
Sbjct: 331 SRKFDPFLDLSLDIP 345
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 127 bits (320), Expect = 4e-29
Identities = 77/201 (38%), Positives = 105/201 (52%), Gaps = 19/201 (9%)
Query: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359
G GL NLGNTCF+N+ LQCLS+T PL D+ L+ ++ E+ G E+ EA+A++I
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
Query: 360 KQMWSGRDAH-VAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKK--P 416
+W V P F+ ++ P FSGY QQD+QE L L++ LH ++NR ++ P
Sbjct: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
Query: 417 YLELKDANGRP-------------DAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPE 463
L P D A W+ + R DS IVD F G KS L C
Sbjct: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
Query: 464 CAKVSVTFDPFCYLTLPLPLK 484
C S TF+ FC L+LP+P K
Sbjct: 387 CGYRSTTFEVFCDLSLPIPKK 407
Score = 111 bits (277), Expect = 4e-24
Identities = 58/146 (39%), Positives = 87/146 (59%), Gaps = 3/146 (2%)
Query: 776 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 835
V+LRDC LFT E L + C C++ ++TKK + P+ILV+HL RFS +R
Sbjct: 414 VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473
Query: 836 DKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWY 895
K V+FP++ L++ +F + + P VY L A+ NH G++ GHYTA + + W+
Sbjct: 474 KKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHSGSVHYGHYTALCRCQTG--WH 530
Query: 896 YFDDSNVSLASEDQIVTKAAYVLFYQ 921
++DS VS SE+Q+ + YVLFYQ
Sbjct: 531 VYNDSRVSPVSENQVASSEGYVLFYQ 556
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 127 bits (320), Expect = 4e-29
Identities = 77/201 (38%), Positives = 105/201 (52%), Gaps = 19/201 (9%)
Query: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359
G GL NLGNTCF+N+ LQCLS+T PL D+ L+ ++ E+ G E+ EA+A++I
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
Query: 360 KQMWSGRDAH-VAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKK--P 416
+W V P F+ ++ P FSGY QQD+QE L L++ LH ++NR ++ P
Sbjct: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
Query: 417 YLELKDANGRP-------------DAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPE 463
L P D A W+ + R DS IVD F G KS L C
Sbjct: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
Query: 464 CAKVSVTFDPFCYLTLPLPLK 484
C S TF+ FC L+LP+P K
Sbjct: 387 CGYRSTTFEVFCDLSLPIPKK 407
Score = 111 bits (277), Expect = 4e-24
Identities = 58/146 (39%), Positives = 87/146 (59%), Gaps = 3/146 (2%)
Query: 776 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 835
V+LRDC LFT E L + C C++ ++TKK + P+ILV+HL RFS +R
Sbjct: 414 VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473
Query: 836 DKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWY 895
K V+FP++ L++ +F + + P VY L A+ NH G++ GHYTA + + W+
Sbjct: 474 KKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHSGSVHYGHYTALCRCQTG--WH 530
Query: 896 YFDDSNVSLASEDQIVTKAAYVLFYQ 921
++DS VS SE+Q+ + YVLFYQ
Sbjct: 531 VYNDSRVSPVSENQVASSEGYVLFYQ 556
>gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens]
Length = 814
Score = 127 bits (319), Expect = 5e-29
Identities = 160/703 (22%), Positives = 275/703 (39%), Gaps = 164/703 (23%)
Query: 303 GLGNLGNTCFMNSALQCLSNTAPLTDYF--LKDE------YEAEINRDNPLGMK----GE 350
G+ NLGNTCF N+ +Q L+ T LTD +K+ + + ++ +PL ++ G
Sbjct: 191 GITNLGNTCFFNAVMQNLAQTYTLTDLMNEIKESSTKLKIFPSSDSQLDPLVVELSRPGP 250
Query: 351 IAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLN 410
+ A + M ++P++ Q+ + AP+F +QQQDSQELL +LLD + +
Sbjct: 251 LTSALFLFLHSMKETEKGPLSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEET 310
Query: 411 RVKKKPYLEL------KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPEC 464
+ + L+ K A+ V E ++ + I F G ST++C EC
Sbjct: 311 KRIQASILKAFNNPTTKTADDETRKKVKAYGKEGVKM---NFIDRIFIGELTSTVMCEEC 367
Query: 465 AKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEAL-- 522
A +S DPF ++LP+ + RV+ PL+ + +L
Sbjct: 368 ANISTVKDPFIDISLPI---------------------IEERVSKPLLWGRMNKYRSLRE 406
Query: 523 ---SRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVT 579
R SG N+ + +++ R K H S+S D S+ +
Sbjct: 407 TDHDRYSG----NVTIENIHQPRAAK--------KH-------------SSSKDKSQLI- 440
Query: 580 LPVYFRERKSRPSSTSSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEF 639
+RK +S + Y + L + L SL + SR + P D
Sbjct: 441 -----HDRKCIRKLSSGETVTYQKNENLEMNGDSLMFASLMNSE----SRLNESPTDDS- 490
Query: 640 GSSPLEPGACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKG 699
E A + N + E E + + GSG G
Sbjct: 491 -----EKEASHSESNVDADSEPSESESASKQTGLFRSSSGSGVQPDG-----------PL 534
Query: 700 QPCPKRLFTFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAY 759
P ++ G ++ ++ L+L+S T D+D E + L
Sbjct: 535 YPLSAGKLLYTKETDSGDKEMAEAISE---LRLSSTVTGDQDFDRENQPLNISNNLCFLE 591
Query: 760 EKHVSMLQPQKKKKTT----------VALRDCIELFTTMETLGEHDPWYCPNCKKHQQ-- 807
KH+ PQ +T +++ C+ FT+ME L ++ C NC K++Q
Sbjct: 592 GKHLRSYSPQNAFQTLSQSYITTSKECSIQSCLYQFTSMELLMGNNKLLCENCTKNKQKY 651
Query: 808 -----------------ATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLN 850
A K+ + ++P +L++HLKRF K++ V+FP+ L+
Sbjct: 652 QEETSFAEKKVEGVYTNARKQLLISAVPAVLILHLKRFHQAGLSLRKVNRHVDFPLM-LD 710
Query: 851 MSEFVCNLSAR------PYVYDLIAVSNHYGAMGVGHYTAYAK----------------- 887
++ F C+ + + +Y L + H G+M GHYTAY K
Sbjct: 711 LAPF-CSATCKNASVGDKVLYGLYGIVEHSGSMREGHYTAYVKVRTPSRKLSEHNTKKKN 769
Query: 888 --------NKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQR 922
N+ G+W + D+ + + E + ++ AY+LFY+R
Sbjct: 770 VPGLKAADNESAGQWVHVSDTYLQVVPESRALSAQAYLLFYER 812
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 118 bits (295), Expect = 3e-26
Identities = 59/155 (38%), Positives = 87/155 (56%), Gaps = 1/155 (0%)
Query: 776 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 835
V L+DC+ F + L + + C CKK + K + + P+IL +HLKRF + +
Sbjct: 559 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 618
Query: 836 DKLDTVVEFPIRGLNMSEFVCNLS-ARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 894
K+ T V FP+ GL++ F+ S A+ YDL++V H+G GHY AY +N LN W
Sbjct: 619 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW 678
Query: 895 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYK 929
Y FDD +V+ SE + AYVLFY++ +E K
Sbjct: 679 YEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQK 713
Score = 87.8 bits (216), Expect = 4e-17
Identities = 53/146 (36%), Positives = 79/146 (54%), Gaps = 14/146 (9%)
Query: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359
GL GL N+GNTC+MN+ALQ LSN PLT +FL A ++ K I ++Y +L+
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK------KPAICKSYLKLM 236
Query: 360 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
++W R V P + P F GY QQD+QE L L+D LHE+L K+ +
Sbjct: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL----KEQVM 292
Query: 419 ELKDANGRPDAVVAKEAWENHRLRND 444
E+++ P + +E E + ++D
Sbjct: 293 EVEE---DPQTITTEETMEEDKSQSD 315
Score = 39.7 bits (91), Expect = 0.014
Identities = 20/42 (47%), Positives = 27/42 (64%)
Query: 445 SVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 486
SVI D F G S++ C C +VSVT + F L+LP+P K+D
Sbjct: 473 SVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514
>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
Length = 942
Score = 118 bits (295), Expect = 3e-26
Identities = 59/155 (38%), Positives = 87/155 (56%), Gaps = 1/155 (0%)
Query: 776 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 835
V L+DC+ F + L + + C CKK + K + + P+IL +HLKRF + +
Sbjct: 567 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 626
Query: 836 DKLDTVVEFPIRGLNMSEFVCNLS-ARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 894
K+ T V FP+ GL++ F+ S A+ YDL++V H+G GHY AY +N LN W
Sbjct: 627 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW 686
Query: 895 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYK 929
Y FDD +V+ SE + AYVLFY++ +E K
Sbjct: 687 YEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQK 721
Score = 87.8 bits (216), Expect = 4e-17
Identities = 53/146 (36%), Positives = 79/146 (54%), Gaps = 14/146 (9%)
Query: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359
GL GL N+GNTC+MN+ALQ LSN PLT +FL A ++ K I ++Y +L+
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK------KPAICKSYLKLM 236
Query: 360 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
++W R V P + P F GY QQD+QE L L+D LHE+L K+ +
Sbjct: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL----KEQVM 292
Query: 419 ELKDANGRPDAVVAKEAWENHRLRND 444
E+++ P + +E E + ++D
Sbjct: 293 EVEE---DPQTITTEETMEEDKSQSD 315
Score = 39.7 bits (91), Expect = 0.014
Identities = 20/42 (47%), Positives = 27/42 (64%)
Query: 445 SVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 486
SVI D F G S++ C C +VSVT + F L+LP+P K+D
Sbjct: 473 SVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514
Score = 36.2 bits (82), Expect = 0.15
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 14/93 (15%)
Query: 32 AQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDEL 91
A +Y I +WF++W+ +V G+ PGPIDN+ + + L
Sbjct: 845 ATFYCISMQWFREWESFV---------KGKDGDPPGPIDNTKIAVTKCGNVM---LRQGA 892
Query: 92 DYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEH 124
D + E WN L + YG G + I+R V H
Sbjct: 893 DSGQISEETWNFLQSIYG--GGPEVILRPPVVH 923
>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
Length = 911
Score = 118 bits (295), Expect = 3e-26
Identities = 59/155 (38%), Positives = 87/155 (56%), Gaps = 1/155 (0%)
Query: 776 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 835
V L+DC+ F + L + + C CKK + K + + P+IL +HLKRF + +
Sbjct: 536 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 595
Query: 836 DKLDTVVEFPIRGLNMSEFVCNLS-ARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 894
K+ T V FP+ GL++ F+ S A+ YDL++V H+G GHY AY +N LN W
Sbjct: 596 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW 655
Query: 895 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYK 929
Y FDD +V+ SE + AYVLFY++ +E K
Sbjct: 656 YEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQK 690
Score = 87.8 bits (216), Expect = 4e-17
Identities = 53/146 (36%), Positives = 79/146 (54%), Gaps = 14/146 (9%)
Query: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359
GL GL N+GNTC+MN+ALQ LSN PLT +FL A ++ K I ++Y +L+
Sbjct: 152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK------KPAICKSYLKLM 205
Query: 360 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
++W R V P + P F GY QQD+QE L L+D LHE+L K+ +
Sbjct: 206 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL----KEQVM 261
Query: 419 ELKDANGRPDAVVAKEAWENHRLRND 444
E+++ P + +E E + ++D
Sbjct: 262 EVEE---DPQTITTEETMEEDKSQSD 284
Score = 39.7 bits (91), Expect = 0.014
Identities = 20/42 (47%), Positives = 27/42 (64%)
Query: 445 SVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 486
SVI D F G S++ C C +VSVT + F L+LP+P K+D
Sbjct: 442 SVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 483
Score = 36.2 bits (82), Expect = 0.15
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 14/93 (15%)
Query: 32 AQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDEL 91
A +Y I +WF++W+ +V G+ PGPIDN+ + + L
Sbjct: 814 ATFYCISMQWFREWESFV---------KGKDGDPPGPIDNTKIAVTKCGNVM---LRQGA 861
Query: 92 DYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEH 124
D + E WN L + YG G + I+R V H
Sbjct: 862 DSGQISEETWNFLQSIYG--GGPEVILRPPVVH 892
>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 112 bits (281), Expect = 1e-24
Identities = 55/152 (36%), Positives = 86/152 (56%), Gaps = 1/152 (0%)
Query: 776 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 835
V L DC+ F + L + + C CKK + K + LP+IL +HLKRF + +
Sbjct: 537 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596
Query: 836 DKLDTVVEFPIRGLNMSEFVCN-LSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 894
K+++ V FP+ GL++ F+ +++ YDL++V H+G G GHY AY +N +NG+W
Sbjct: 597 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQW 656
Query: 895 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDE 926
Y FDD V+ E + YVLFY++ +E
Sbjct: 657 YEFDDQYVTEVHETVVQNAEGYVLFYRKSSEE 688
Score = 84.3 bits (207), Expect = 5e-16
Identities = 46/111 (41%), Positives = 65/111 (58%), Gaps = 7/111 (6%)
Query: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359
GL G+ NLGN+C+MN+ALQ LSN PLT +FL E + D K + ++Y +L+
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL--ECGGLVRTDK----KPALCKSYQKLV 196
Query: 360 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDL 409
++W R ++V P + P F GY QQD+QE L L+D LHE+L
Sbjct: 197 SEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
Score = 38.1 bits (87), Expect = 0.040
Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 11/75 (14%)
Query: 35 YLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYV 94
Y I +WF++W+ +V G+ N PGPIDNS + S ++ L DY
Sbjct: 818 YCISMQWFREWEAFVK---------GKDNEPPGPIDNSRIAQVKGSGHVQ--LKQGADYG 866
Query: 95 LVPTEAWNKLLNWYG 109
+ E W L + YG
Sbjct: 867 QISEETWTYLNSLYG 881
Score = 37.4 bits (85), Expect = 0.068
Identities = 20/45 (44%), Positives = 26/45 (57%)
Query: 442 RNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 486
R SVI D F G S + C C +VS T + F L+LP+P K+D
Sbjct: 440 RYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKED 484
>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 112 bits (281), Expect = 1e-24
Identities = 55/152 (36%), Positives = 86/152 (56%), Gaps = 1/152 (0%)
Query: 776 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 835
V L DC+ F + L + + C CKK + K + LP+IL +HLKRF + +
Sbjct: 537 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596
Query: 836 DKLDTVVEFPIRGLNMSEFVCN-LSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 894
K+++ V FP+ GL++ F+ +++ YDL++V H+G G GHY AY +N +NG+W
Sbjct: 597 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQW 656
Query: 895 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDE 926
Y FDD V+ E + YVLFY++ +E
Sbjct: 657 YEFDDQYVTEVHETVVQNAEGYVLFYRKSSEE 688
Score = 84.3 bits (207), Expect = 5e-16
Identities = 46/111 (41%), Positives = 65/111 (58%), Gaps = 7/111 (6%)
Query: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359
GL G+ NLGN+C+MN+ALQ LSN PLT +FL E + D K + ++Y +L+
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL--ECGGLVRTDK----KPALCKSYQKLV 196
Query: 360 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDL 409
++W R ++V P + P F GY QQD+QE L L+D LHE+L
Sbjct: 197 SEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
Score = 38.1 bits (87), Expect = 0.040
Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 11/75 (14%)
Query: 35 YLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYV 94
Y I +WF++W+ +V G+ N PGPIDNS + S ++ L DY
Sbjct: 818 YCISMQWFREWEAFVK---------GKDNEPPGPIDNSRIAQVKGSGHVQ--LKQGADYG 866
Query: 95 LVPTEAWNKLLNWYG 109
+ E W L + YG
Sbjct: 867 QISEETWTYLNSLYG 881
Score = 37.4 bits (85), Expect = 0.068
Identities = 20/45 (44%), Positives = 26/45 (57%)
Query: 442 RNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 486
R SVI D F G S + C C +VS T + F L+LP+P K+D
Sbjct: 440 RYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKED 484
>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 112 bits (281), Expect = 1e-24
Identities = 55/152 (36%), Positives = 86/152 (56%), Gaps = 1/152 (0%)
Query: 776 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 835
V L DC+ F + L + + C CKK + K + LP+IL +HLKRF + +
Sbjct: 537 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596
Query: 836 DKLDTVVEFPIRGLNMSEFVCN-LSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 894
K+++ V FP+ GL++ F+ +++ YDL++V H+G G GHY AY +N +NG+W
Sbjct: 597 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQW 656
Query: 895 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDE 926
Y FDD V+ E + YVLFY++ +E
Sbjct: 657 YEFDDQYVTEVHETVVQNAEGYVLFYRKSSEE 688
Score = 84.3 bits (207), Expect = 5e-16
Identities = 46/111 (41%), Positives = 65/111 (58%), Gaps = 7/111 (6%)
Query: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359
GL G+ NLGN+C+MN+ALQ LSN PLT +FL E + D K + ++Y +L+
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL--ECGGLVRTDK----KPALCKSYQKLV 196
Query: 360 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDL 409
++W R ++V P + P F GY QQD+QE L L+D LHE+L
Sbjct: 197 SEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
Score = 38.1 bits (87), Expect = 0.040
Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 11/75 (14%)
Query: 35 YLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYV 94
Y I +WF++W+ +V G+ N PGPIDNS + S ++ L DY
Sbjct: 818 YCISMQWFREWEAFVK---------GKDNEPPGPIDNSRIAQVKGSGHVQ--LKQGADYG 866
Query: 95 LVPTEAWNKLLNWYG 109
+ E W L + YG
Sbjct: 867 QISEETWTYLNSLYG 881
Score = 37.4 bits (85), Expect = 0.068
Identities = 20/45 (44%), Positives = 26/45 (57%)
Query: 442 RNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 486
R SVI D F G S + C C +VS T + F L+LP+P K+D
Sbjct: 440 RYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKED 484
>gi|239751420 PREDICTED: similar to hCG2039376 [Homo sapiens]
Length = 858
Score = 100 bits (248), Expect = 9e-21
Identities = 44/84 (52%), Positives = 61/84 (72%), Gaps = 2/84 (2%)
Query: 298 QPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAE 357
+ G GL NLGNTCFMNS++QC+SNT PLT YF+ + E+NR NP+GMKG +A+ Y +
Sbjct: 775 EKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGD 834
Query: 358 LIKQMWSGRDAHVAPRMFKTQVGR 381
L++++WSG +VAP K +V R
Sbjct: 835 LVQELWSGTQKNVAP--LKLRVSR 856
Score = 38.1 bits (87), Expect = 0.040
Identities = 13/29 (44%), Positives = 21/29 (72%)
Query: 25 RTTLQRGAQWYLIDSRWFKQWKKYVGFDS 53
R LQ G W++I +W++QWK+YV +D+
Sbjct: 455 RYGLQAGHNWFIISMQWWQQWKEYVKYDA 483
Score = 31.6 bits (70), Expect = 3.7
Identities = 20/55 (36%), Positives = 23/55 (41%), Gaps = 11/55 (20%)
Query: 66 PGPIDNSGLFSDP---------ESQTLKE--HLIDELDYVLVPTEAWNKLLNWYG 109
PG IDN L + E LK LI DY +VP W L +WYG
Sbjct: 589 PGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYG 643
>gi|45267835 ubiquitin specific protease 50 [Homo sapiens]
Length = 339
Score = 95.9 bits (237), Expect = 2e-19
Identities = 61/189 (32%), Positives = 92/189 (48%), Gaps = 8/189 (4%)
Query: 296 HIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAY 355
H Q G+ GL NLGNTC +N+ QCL + PL +YFL +Y + + E+A A+
Sbjct: 39 HFQ-GVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLPSDCSEVATAF 97
Query: 356 AELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKK 415
A L+ MW G V+P +F + +G P F+ QQD+QE L +L+ LHE L KK
Sbjct: 98 AYLMTDMWLGDSDCVSPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEAL----KK 153
Query: 416 PYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFC 475
+ + + + W S+I F ++VC +C K + + F
Sbjct: 154 YHYSRRRSYEKGSTQRCCRKWIT---TETSIITQLFEEQLNYSIVCLKCEKCTYKNEVFT 210
Query: 476 YLTLPLPLK 484
+LP+P K
Sbjct: 211 VFSLPIPSK 219
Score = 85.5 bits (210), Expect = 2e-16
Identities = 38/118 (32%), Positives = 68/118 (57%)
Query: 773 KTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNR 832
K +LRDC++ F + L ++ +C C+ Q+ + + PKI++ HLKRF
Sbjct: 219 KYECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQG 278
Query: 833 YWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKL 890
+ KL T + +P+ L+++ ++C++ + Y+L AV NH+G + GHYTA+ KN +
Sbjct: 279 TTKRKLRTDIHYPLTNLDLTPYICSIFRKYPKYNLCAVVNHFGDLDGGHYTAFCKNSV 336
>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
Length = 822
Score = 90.1 bits (222), Expect = 9e-18
Identities = 63/204 (30%), Positives = 100/204 (49%), Gaps = 14/204 (6%)
Query: 292 PPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNP------- 344
P +S Q + GL NLGNTCF N+ +Q LS T L + + + I + P
Sbjct: 185 PMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTE 244
Query: 345 -----LGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLA 399
L G + A ++ + +M + V P+ +QV + A +F GYQQQDSQELL
Sbjct: 245 PLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLR 304
Query: 400 FLLDGLH-EDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVD-TFHGLFKS 457
+LLDG+ E+ RV K ++ + D + + + + ++ VD F G S
Sbjct: 305 YLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTS 364
Query: 458 TLVCPECAKVSVTFDPFCYLTLPL 481
++C +C VS+ + F L+LP+
Sbjct: 365 MIMCDQCRTVSLVHESFLDLSLPV 388
Score = 63.9 bits (154), Expect = 7e-10
Identities = 48/192 (25%), Positives = 80/192 (41%), Gaps = 48/192 (25%)
Query: 777 ALRDCIELFTTMETLGEHDPWYCPNCKKHQ-----------------QATKKFDLWSLPK 819
+++ C+ FT E L + + C C + Q A K+ + P
Sbjct: 631 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 690
Query: 820 ILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPY-------VYDLIAVSN 872
+L +HLKRF + K++ ++FP L+++ F C L + +Y L V
Sbjct: 691 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPF-CTLKCKNVAEENTRVLYSLYGVVE 748
Query: 873 HYGAMGVGHYTAYAKNKL----------------------NGKWYYFDDSNVSLASEDQI 910
H G M GHYTAYAK + G+W++ D++V ++
Sbjct: 749 HSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKV 808
Query: 911 VTKAAYVLFYQR 922
+ AY+LFY+R
Sbjct: 809 LNSQAYLLFYER 820
>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 90.1 bits (222), Expect = 9e-18
Identities = 63/204 (30%), Positives = 100/204 (49%), Gaps = 14/204 (6%)
Query: 292 PPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNP------- 344
P +S Q + GL NLGNTCF N+ +Q LS T L + + + I + P
Sbjct: 186 PMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTE 245
Query: 345 -----LGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLA 399
L G + A ++ + +M + V P+ +QV + A +F GYQQQDSQELL
Sbjct: 246 PLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLR 305
Query: 400 FLLDGLH-EDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVD-TFHGLFKS 457
+LLDG+ E+ RV K ++ + D + + + + ++ VD F G S
Sbjct: 306 YLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTS 365
Query: 458 TLVCPECAKVSVTFDPFCYLTLPL 481
++C +C VS+ + F L+LP+
Sbjct: 366 MIMCDQCRTVSLVHESFLDLSLPV 389
Score = 63.9 bits (154), Expect = 7e-10
Identities = 48/192 (25%), Positives = 80/192 (41%), Gaps = 48/192 (25%)
Query: 777 ALRDCIELFTTMETLGEHDPWYCPNCKKHQ-----------------QATKKFDLWSLPK 819
+++ C+ FT E L + + C C + Q A K+ + P
Sbjct: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
Query: 820 ILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPY-------VYDLIAVSN 872
+L +HLKRF + K++ ++FP L+++ F C L + +Y L V
Sbjct: 692 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPF-CTLKCKNVAEENTRVLYSLYGVVE 749
Query: 873 HYGAMGVGHYTAYAKNKL----------------------NGKWYYFDDSNVSLASEDQI 910
H G M GHYTAYAK + G+W++ D++V ++
Sbjct: 750 HSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKV 809
Query: 911 VTKAAYVLFYQR 922
+ AY+LFY+R
Sbjct: 810 LNSQAYLLFYER 821
>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 90.1 bits (222), Expect = 9e-18
Identities = 63/204 (30%), Positives = 100/204 (49%), Gaps = 14/204 (6%)
Query: 292 PPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNP------- 344
P +S Q + GL NLGNTCF N+ +Q LS T L + + + I + P
Sbjct: 186 PMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTE 245
Query: 345 -----LGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLA 399
L G + A ++ + +M + V P+ +QV + A +F GYQQQDSQELL
Sbjct: 246 PLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLR 305
Query: 400 FLLDGLH-EDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVD-TFHGLFKS 457
+LLDG+ E+ RV K ++ + D + + + + ++ VD F G S
Sbjct: 306 YLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTS 365
Query: 458 TLVCPECAKVSVTFDPFCYLTLPL 481
++C +C VS+ + F L+LP+
Sbjct: 366 MIMCDQCRTVSLVHESFLDLSLPV 389
Score = 63.9 bits (154), Expect = 7e-10
Identities = 48/192 (25%), Positives = 80/192 (41%), Gaps = 48/192 (25%)
Query: 777 ALRDCIELFTTMETLGEHDPWYCPNCKKHQ-----------------QATKKFDLWSLPK 819
+++ C+ FT E L + + C C + Q A K+ + P
Sbjct: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
Query: 820 ILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPY-------VYDLIAVSN 872
+L +HLKRF + K++ ++FP L+++ F C L + +Y L V
Sbjct: 692 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPF-CTLKCKNVAEENTRVLYSLYGVVE 749
Query: 873 HYGAMGVGHYTAYAKNKL----------------------NGKWYYFDDSNVSLASEDQI 910
H G M GHYTAYAK + G+W++ D++V ++
Sbjct: 750 HSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKV 809
Query: 911 VTKAAYVLFYQR 922
+ AY+LFY+R
Sbjct: 810 LNSQAYLLFYER 821
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 88.2 bits (217), Expect = 3e-17
Identities = 51/168 (30%), Positives = 81/168 (48%), Gaps = 17/168 (10%)
Query: 775 TVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYW 834
T L DC+ FT E LG C C +Q++TK+ + LP + HLKRF ++
Sbjct: 359 TTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKL 418
Query: 835 RDKLDTVVEFPIRGLNMSEFVCNLSA---------------RPYVYDLIAVSNHYGAMGV 879
R K+ T V FP+ L+M+ F+ + Y L AV NH G +
Sbjct: 419 RRKITTYVSFPLE-LDMTPFMASSKESRMNGQYQQPTDSLNNDNKYSLFAVVNHQGTLES 477
Query: 880 GHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEF 927
GHYT++ + +W+ DD+ ++ AS ++ Y+LFY ++ E+
Sbjct: 478 GHYTSFIRQH-KDQWFKCDDAIITKASIKDVLDSEGYLLFYHKQFLEY 524
Score = 81.6 bits (200), Expect = 3e-15
Identities = 59/189 (31%), Positives = 85/189 (44%), Gaps = 24/189 (12%)
Query: 294 SSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAE 353
+S+ GL GL NLGNTCFMN +Q L++T L D+FL D + E+ + +
Sbjct: 168 TSNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSC-----LVC 222
Query: 354 AYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVK 413
+ L ++ +SG + P V A +GY+QQD+ E L LD LH
Sbjct: 223 EMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCK--- 279
Query: 414 KKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDP 473
D NG+ N+ + +I F G +S + C C VS T DP
Sbjct: 280 -------GDDNGKK---------ANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDP 323
Query: 474 FCYLTLPLP 482
F ++L LP
Sbjct: 324 FWDISLDLP 332
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,286,407
Number of Sequences: 37866
Number of extensions: 1876073
Number of successful extensions: 10647
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 9040
Number of HSP's gapped (non-prelim): 1047
length of query: 963
length of database: 18,247,518
effective HSP length: 112
effective length of query: 851
effective length of database: 14,006,526
effective search space: 11919553626
effective search space used: 11919553626
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.