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Search of human proteins with 40255157
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40255157 leucine-rich repeats and immunoglobulin-like
domains 3 isoform 2 [Homo sapiens]
(1119 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 2265 0.0
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 2108 0.0
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 1137 0.0
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 990 0.0
gi|109150416 peroxidasin [Homo sapiens] 222 1e-57
gi|126517478 peroxidasin homolog-like [Homo sapiens] 212 2e-54
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 179 1e-44
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 179 1e-44
gi|4826772 insulin-like growth factor binding protein, acid labi... 164 6e-40
gi|225579152 insulin-like growth factor binding protein, acid la... 162 2e-39
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 155 3e-37
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 153 8e-37
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 149 2e-35
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 147 7e-35
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 145 2e-34
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 145 3e-34
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 140 7e-33
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 139 1e-32
gi|198041768 synleurin [Homo sapiens] 138 3e-32
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 133 8e-31
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 131 3e-30
gi|4759146 slit homolog 2 [Homo sapiens] 129 2e-29
gi|51317373 netrin-G1 ligand [Homo sapiens] 126 1e-28
gi|19743806 roundabout 1 isoform b [Homo sapiens] 124 4e-28
gi|4506569 roundabout 1 isoform a [Homo sapiens] 124 4e-28
gi|118572606 hemicentin 1 [Homo sapiens] 123 9e-28
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 123 9e-28
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 121 3e-27
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 121 4e-27
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 120 6e-27
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 2265 bits (5870), Expect = 0.0
Identities = 1119/1119 (100%), Positives = 1119/1119 (100%)
Query: 1 MSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDC 60
MSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDC
Sbjct: 1 MSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDC 60
Query: 61 SRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS 120
SRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS
Sbjct: 61 SRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS 120
Query: 121 ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVT 180
ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVT
Sbjct: 121 ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVT 180
Query: 181 SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA 240
SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA
Sbjct: 181 SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA 240
Query: 241 LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 300
LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN
Sbjct: 241 LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 300
Query: 301 RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS 360
RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS
Sbjct: 301 RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS 360
Query: 361 LKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN 420
LKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN
Sbjct: 361 LKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN 420
Query: 421 AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKG 480
AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKG
Sbjct: 421 AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKG 480
Query: 481 RSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL 540
RSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL
Sbjct: 481 RSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL 540
Query: 541 LHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVN 600
LHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVN
Sbjct: 541 LHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVN 600
Query: 601 MLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDV 660
MLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDV
Sbjct: 601 MLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDV 660
Query: 661 FFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIA 720
FFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIA
Sbjct: 661 FFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIA 720
Query: 721 GGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV 780
GGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV
Sbjct: 721 GGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV 780
Query: 781 RLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDC 840
RLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDC
Sbjct: 781 RLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDC 840
Query: 841 SITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGT 900
SITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGT
Sbjct: 841 SITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGT 900
Query: 901 CHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHY 960
CHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHY
Sbjct: 901 CHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHY 960
Query: 961 EPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSL 1020
EPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSL
Sbjct: 961 EPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSL 1020
Query: 1021 DFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSG 1080
DFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSG
Sbjct: 1021 DFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSG 1080
Query: 1081 SEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT 1119
SEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT
Sbjct: 1081 SEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT 1119
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 2108 bits (5462), Expect = 0.0
Identities = 1041/1044 (99%), Positives = 1043/1044 (99%)
Query: 76 VARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVE 135
++R DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVE
Sbjct: 16 ISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVE 75
Query: 136 ILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLL 195
ILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLL
Sbjct: 76 ILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLL 135
Query: 196 VLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 255
VLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM
Sbjct: 136 VLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195
Query: 256 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 315
DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE
Sbjct: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255
Query: 316 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI 375
LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI
Sbjct: 256 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI 315
Query: 376 EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK 435
EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK
Sbjct: 316 EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK 375
Query: 436 LQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDD 495
LQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDD
Sbjct: 376 LQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDD 435
Query: 496 FPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQ 555
FPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQ
Sbjct: 436 FPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQ 495
Query: 556 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR 615
GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR
Sbjct: 496 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR 555
Query: 616 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 675
AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS
Sbjct: 556 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 615
Query: 676 CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDS 735
CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDS
Sbjct: 616 CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDS 675
Query: 736 PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM 795
PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM
Sbjct: 676 PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM 735
Query: 796 TAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIP 855
TAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIP
Sbjct: 736 TAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIP 795
Query: 856 SYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAAT 915
SYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAAT
Sbjct: 796 SYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAAT 855
Query: 916 DLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSH 975
DLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSH
Sbjct: 856 DLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSH 915
Query: 976 PSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSN 1035
PSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSN
Sbjct: 916 PSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSN 975
Query: 1036 SFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEEN 1095
SFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEEN
Sbjct: 976 SFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEEN 1035
Query: 1096 HICTFKQTLENYRTPNFQSYDLDT 1119
HICTFKQTLENYRTPNFQSYDLDT
Sbjct: 1036 HICTFKQTLENYRTPNFQSYDLDT 1059
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 1137 bits (2941), Expect = 0.0
Identities = 585/945 (61%), Positives = 724/945 (76%), Gaps = 28/945 (2%)
Query: 47 CPTTCRCLGDLLDCSRKRLARLPEPLPSW----------VARLDLSHNRLSFIKASSMSH 96
CP C C LLDCSR++L P PSW A LD SHNRLS S S
Sbjct: 43 CPAPCSCRIPLLDCSRRKL-----PAPSWRALSGLLPPDTAILDFSHNRLSNWNISLES- 96
Query: 97 LQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNN 156
Q+L+EVK+N NEL IP G ++NITLLSL N I EI + L+ + +LE+LDLSSN
Sbjct: 97 -QTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNI 155
Query: 157 ISELQTA-FPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLP 215
ISE++T+ FP +QLKYL L++NR+T++E G FDNL+++LLV+KLNRNR+S IPPK+FKLP
Sbjct: 156 ISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLP 215
Query: 216 QLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNL 275
LQ LEL RN+IK V+GLTFQGL +L+SLKMQRNG++KL DGAF+GL+NME L+L+HNNL
Sbjct: 216 HLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNL 275
Query: 276 TEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLS 335
T + KGWLYGL MLQ+L++SQNAI RISPDAWEFCQ+LSELDL++N L+RLD+S+F+GLS
Sbjct: 276 TRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLS 335
Query: 336 LLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQG 395
LL L++G+NRV++IAD FR LS+L+TLDL+NNEISW IED + AF+GL L +LILQG
Sbjct: 336 LLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQG 395
Query: 396 NRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWL 455
N+I+SITKKAF GL++LEHLDL++NAIMS+Q NAFSQ L++L LNTSSLLCDC LKWL
Sbjct: 396 NQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH-LKELILNTSSLLCDCHLKWL 454
Query: 456 PQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSN 515
QW+ +NNFQ VN SCAHP+ L G+SI V FVCDDF KPQI PET A++G N
Sbjct: 455 LQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMN 514
Query: 516 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 575
++ C+A SSSDSPM+ W+KD+E+L+D + EN+ Q GE +EYT+IL L V F
Sbjct: 515 VTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTD 574
Query: 576 EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIA 635
EGKYQC+++NHFGS+YS KAKLTVN +PSF KTPMDLTIR GAMARLECAA GHPAPQI+
Sbjct: 575 EGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQIS 634
Query: 636 WQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLE 695
WQKDGGTDFPAARERRMHVMPEDDVFFI +VKIED+G+YSC AQN+AG +SANA+LTVLE
Sbjct: 635 WQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLE 694
Query: 696 TPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIV 755
TPSF+RPL D+TVT+GETAVLQCIAGGSP P+LNWTKDD PL+VTERHFFAA NQLLIIV
Sbjct: 695 TPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIV 754
Query: 756 DSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAV 815
D+ + DAGKYTC MSNTLGTERG++ L+VI +P CDS Q ++ +DDGW TVG+VII V
Sbjct: 755 DAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQ-SSIGHEDDGWTTVGIVIIVV 813
Query: 816 VCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSE 875
VCCVVGTSL+WV++IYH RR+NED SITNT+E NLPADIPSYLSSQGTL++ Q+GY +SE
Sbjct: 814 VCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSE 873
Query: 876 SGSHHQFVTSSGAGFFLPQHDSSGTCHI--DNSSEADVEAATDLFLCPFLGSTGPMYLK- 932
+GSH Q + + +GT I D A++ + T + CP+ L
Sbjct: 874 AGSHQQLMPPANGYIHKGTDGGTGTRVICSDCYDNANIYSRTREY-CPYTYIAEEDVLDQ 932
Query: 933 --GNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSH 975
++ P ETY P T ++ PS ++ +P +H
Sbjct: 933 TLSSLMVQMPKETYLV--HPPQDTTALESLIPSANREPSAFPTNH 975
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 990 bits (2560), Expect = 0.0
Identities = 533/1018 (52%), Positives = 685/1018 (67%), Gaps = 38/1018 (3%)
Query: 46 PCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKL 105
PC C C GD LDC + LA LP LPSW L+LS+N+LS I + L +L+EV L
Sbjct: 40 PCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYL 99
Query: 106 NNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ-TAF 164
NNNEL +P+LG S+++ L L N+I + LK + SLE LDLS NNI+E++ T F
Sbjct: 100 NNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCF 159
Query: 165 P-ALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELN 223
P +K L L NR+ ++E G FD L+ +LL L+L++NRI+ +P + FKLP+L L+LN
Sbjct: 160 PHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLN 219
Query: 224 RNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWL 283
RN+I+ ++GLTFQGL +L+ LK+QRN ++KL DGAFWGLS M +L L++N+L E+ G L
Sbjct: 220 RNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSL 279
Query: 284 YGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIG 343
YGL L +LHLS N+I RI W FCQKL EL L+FN+L+RLD+ S LS L+ L +
Sbjct: 280 YGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLS 339
Query: 344 NNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITK 403
+N +S+IA+ AF+GL SL+ LDL +NEIS TIED +GAFSGLD L +L L GN+I+S+ K
Sbjct: 340 HNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAK 399
Query: 404 KAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENN 463
+AF+GL+ LEHL+L NAI S+Q +AF +MK L++LH+++ S LCDCQLKWLP W+
Sbjct: 400 RAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRM 459
Query: 464 FQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAA 523
Q+FV A+CAHP+ LKG+SIF+V P+ FVCDDF KPQI QPET A+ G ++ F CSAA
Sbjct: 460 LQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAA 519
Query: 524 SSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVI 583
SSS SPMTFAWKKDNE+L +A+MEN+ H+ AQ GEVMEYTTIL LR+V F EG+YQCVI
Sbjct: 520 SSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVI 579
Query: 584 SNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTD 643
+NHFGS+YS KA+LTVN+LPSFTKTP D+TIR MARLECAA GHP PQIAWQKDGGTD
Sbjct: 580 TNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTD 639
Query: 644 FPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPL 703
FPAARERRMHVMP+DDVFFI DVKI+D GVYSCTAQNSAGSISANATLTVLETPS + PL
Sbjct: 640 FPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPL 699
Query: 704 LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAG 763
DR V+ GET LQC A G+PPP++ W K D PL +TERH NQLL++ + DAG
Sbjct: 700 EDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAG 759
Query: 764 KYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTS 823
+YTCEMSNTLGTER + +LSV+P C DG TVG+ IAVV +V TS
Sbjct: 760 RYTCEMSNTLGTERAHSQLSVLPAAGCRK----------DG-TTVGIFTIAVVSSIVLTS 808
Query: 824 LVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSH-HQF 882
LVWV IIY TR+++E+ S+TNTDET +P D+PSYLSSQGTL+DRQ+ V +E G +
Sbjct: 809 LVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGH 868
Query: 883 VTSSGAGFFLPQHDSSGTCHIDNSSEADVEAATDLFLCPFL------GSTGPMYLK--GN 934
+ S+G H H + + A + P+ G+ GP ++ G
Sbjct: 869 IESNGVCPRDASHFPEPDTHSVACRQPKLCAGSAYHKEPWKAMEKAEGTPGPHKMEHGGR 928
Query: 935 VYGSD---PFETYHTGCSPDPRTVLMDHYEPSYIKKKE----------CYPCSHPSEESC 981
V SD + Y G + P+ V D +PS E + CS + SC
Sbjct: 929 VVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAPNGPEPGGSDQEHSPHHQCSRTAAGSC 988
Query: 982 ERSFSNISWPSHVRKLL---NTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSNS 1036
++ +H R L + +G G + L + S +PAS +S S
Sbjct: 989 PECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSSWTLARLYHPDSTELQPASSLTSGS 1046
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 222 bits (566), Expect = 1e-57
Identities = 153/505 (30%), Positives = 247/505 (48%), Gaps = 37/505 (7%)
Query: 292 LHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIA 351
+HL A+ ++P S LDL FN + + +F L LNTL + NN++ I
Sbjct: 50 MHLLLEAVPAVAPQT-------SILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIP 102
Query: 352 DCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDA 411
AF L +LK L L NEI +I+ AF GL L +L L N+I ++ +F L
Sbjct: 103 SGAFEDLENLKYLYLYKNEIQ-SIDRQ--AFKGLASLEQLYLHFNQIETLDPDSFQHLPK 159
Query: 412 LEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQ----WVAENNFQSF 467
LE L L +N I L F+ ++ +++L L++++L CDC++ WL + N Q+
Sbjct: 160 LERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAA 219
Query: 468 VNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSD 527
A C +P+ ++GRS+ ++P+ C+ +P+IT +P+ G+ + F C A +
Sbjct: 220 --AICEYPRRIQGRSVATITPEELNCE---RPRITSEPQDADVTSGNTVYFTCRA-EGNP 273
Query: 528 SPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHF 587
P + +NEL + ++ +L G L ++ + +G YQC+ N
Sbjct: 274 KPEIIWLRNNNEL--SMKTDSRLNLLDDG--------TLMIQNTQETDQGIYQCMAKNVA 323
Query: 588 GSSYSVKAKLTV---NMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDF 644
G + + L P+F P + + G LEC+A GHP P+I+W + T
Sbjct: 324 GEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPL 383
Query: 645 PAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLL 704
P + R+++ P ++ I +V D G Y+C+A N+ S+ A A + V P F
Sbjct: 384 PV--DPRVNITPSGGLY-IQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQ 440
Query: 705 DRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGK 764
DR V +G+T QC A G+PPP + WTK S L V RH + L I + D G+
Sbjct: 441 DRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLR-ISGVALHDQGQ 499
Query: 765 YTCEMSNTLGTERGNVRLSVIPTPT 789
Y C+ N +G+++ L+V P T
Sbjct: 500 YECQAVNIIGSQKVVAHLTVQPRVT 524
Score = 157 bits (398), Expect = 4e-38
Identities = 158/592 (26%), Positives = 245/592 (41%), Gaps = 65/592 (10%)
Query: 244 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 303
L ++ N + ++ GAF L N+ L L++N + I G L L+ L+L +N I I
Sbjct: 67 LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126
Query: 304 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 363
A++ L +L L FN + LD SF L L L + NNR++++ F L S+K
Sbjct: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKR 186
Query: 364 LDLKNN------EISWTI-------EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLD 410
L L +N EI W E N + + + R I QG + +IT +
Sbjct: 187 LRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRI-QGRSVATITPEELNCER 245
Query: 411 ALEHLDLSDNAIMS---------LQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLP----- 456
+ D + S +GN ++ L+ + N S+ D +L L
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLR--NNNELSMKTDSRLNLLDDGTLM 303
Query: 457 ----QWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIK 512
Q + +Q + + + SP +P +QP+ +
Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSP--------ARPTFVIQPQNTEVLV 355
Query: 513 GSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVE 572
G +++ CSA + P +W + + ++ ++ GG L ++ V
Sbjct: 356 GESVTLECSA--TGHPPPRISWTRGDRT--PLPVDPRVNITPSGG--------LYIQNVV 403
Query: 573 FASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAP 632
G+Y C +N+ S ++ A + V LP FT TP D + G +C A G+P P
Sbjct: 404 QGDSGEYACSATNNIDSVHAT-AFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPP 462
Query: 633 QIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLT 692
IAW K GG+ R H++ I V + D G Y C A N GS A LT
Sbjct: 463 VIAWTK-GGSQLSVDRR---HLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLT 518
Query: 693 VLE--TPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTER-HFFAAGN 749
V TP F D TV G L C + G P P + W KD + VTE F +
Sbjct: 519 VQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDG--VQVTESGKFHISPE 576
Query: 750 QLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV-IPTPTCDSPQMTAPSL 800
L I D +DAG+Y C NT+G+ ++ LSV +P + + A S+
Sbjct: 577 GFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSI 628
Score = 71.2 bits (173), Expect = 5e-12
Identities = 49/144 (34%), Positives = 76/144 (52%), Gaps = 4/144 (2%)
Query: 160 LQTAFPAL--QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQ 216
L A PA+ Q L L NR+ ++PG F L N L L LN N+I IP F+ L
Sbjct: 53 LLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRN-LNTLLLNNNQIKRIPSGAFEDLEN 111
Query: 217 LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLT 276
L++L L +N+I+++D F+GL +L+ L + N + L +F L +E L L +N +T
Sbjct: 112 LKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRIT 171
Query: 277 EITKGWLYGLLMLQELHLSQNAIN 300
+ G L ++ L L N ++
Sbjct: 172 HLVPGTFNHLESMKRLRLDSNTLH 195
Score = 70.5 bits (171), Expect = 9e-12
Identities = 56/171 (32%), Positives = 89/171 (52%), Gaps = 10/171 (5%)
Query: 41 VAAERP---CPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHL 97
V A++P CP+ C C + C L +P P + LDL NR+ I+ + L
Sbjct: 27 VVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQ-TSILDLRFNRIREIQPGAFRRL 85
Query: 98 QSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSN 155
++L + LNNN+++ IP+ G N+ L L N I I + K SLE L L N
Sbjct: 86 RNLNTLLLNNNQIKRIPS-GAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFN 144
Query: 156 NISELQ-TAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRI 204
I L +F L +L+ L+L++NR+T + PG F++L ++ L+L+ N +
Sbjct: 145 QIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHL-ESMKRLRLDSNTL 194
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 212 bits (539), Expect = 2e-54
Identities = 144/481 (29%), Positives = 234/481 (48%), Gaps = 28/481 (5%)
Query: 311 QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNE 370
Q+ + LDL FN + + S+F L LNTL + NN + I+ AF GL +L L L NE
Sbjct: 50 QQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNE 109
Query: 371 ISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF 430
I + F GL L L + N++ + + F L LE L L +N + + +F
Sbjct: 110 IHALDKQ---TFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSF 166
Query: 431 SQMKKLQQLHLNTSSLLCDCQLKWLPQWVA--ENNFQSFVNASCAHPQLLKGRSIFAVSP 488
S + L++L L++++L+CDC L WL + + + + A+C +P+ L GR++ +V+
Sbjct: 167 SNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTV 226
Query: 489 DGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMEN 548
+ F C P+IT +P+ G+ + F C A + + W +N H ++E+
Sbjct: 227 EEFNCQ---SPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEI--IWIHNN---HSLDLED 278
Query: 549 YAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML---PSF 605
L V + T++ +R + +G YQC+ N G + + A L + L PSF
Sbjct: 279 DTRL-----NVFDDGTLM-IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSF 332
Query: 606 TKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVD 665
P D + G LEC A GHP P I W +D G + +R HV + ++ +
Sbjct: 333 VIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSR----HVATSSGL-YLQN 387
Query: 666 VKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPP 725
+ D G ++C A NS G++ A A + V P F D+ V + C A G+PP
Sbjct: 388 ITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPP 447
Query: 726 PKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVI 785
P + WTK L V +H + L I + D G+Y C+ ++LG ++ +V+L+V
Sbjct: 448 PVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQ-HDQGQYECQAVSSLGVKKVSVQLTVK 506
Query: 786 P 786
P
Sbjct: 507 P 507
Score = 128 bits (321), Expect = 3e-29
Identities = 145/600 (24%), Positives = 231/600 (38%), Gaps = 92/600 (15%)
Query: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279
L+L N+I+ + G F+ L L +L + N + K+ AF GL N+ L L N + +
Sbjct: 55 LDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALD 114
Query: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 339
K GL+ L+ L++ N + + P+ TF L RL+
Sbjct: 115 KQTFKGLISLEHLYIHFNQLEMLQPE-------------TFGDLLRLE-----------R 150
Query: 340 LHIGNNRVSYIADCAFRGLSSLKTLDLKNN------EISWTIEDMNG--------AFSGL 385
L + NN++S I +F L SLK L L +N ++ W E + G A +
Sbjct: 151 LFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATC 210
Query: 386 DKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF--------SQMKKLQ 437
+ RRL G + S+T + F + D + S GN + ++
Sbjct: 211 EYPRRL--HGRAVASVTVEEFNCQSPRITFEPQDVEVPS--GNTVYFTCRAEGNPKPEII 266
Query: 438 QLHLNTS-SLLCDCQLKWLPQWVA---------ENNFQSFVNASCAHPQLLKGRSIFAVS 487
+H N S L D +L + +Q S + ++
Sbjct: 267 WIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSL 326
Query: 488 PDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEME 547
P KP +QP+ + G++ + C A +T W +DN L E++
Sbjct: 327 P--------AKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLIT--WTRDNGL----ELD 372
Query: 548 NYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTK 607
H+ G L L+ + G++ C +N G+ + A + V P FT
Sbjct: 373 GSRHVATSSG--------LYLQNITQRDHGRFTCHANNSHGTVQAA-ANIIVQAPPQFTV 423
Query: 608 TPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVK 667
TP D + C A G+P P I W K GG P + H + I
Sbjct: 424 TPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGG-QLPVEGQ---HTVLSSGTLRIDRAA 479
Query: 668 IEDIGVYSCTAQNSAG--SISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPP 725
D G Y C A +S G +S T+ F + D +V G+ + C A G P
Sbjct: 480 QHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQ 539
Query: 726 PKLNWTKDDSPLVVTERHFFAAGNQ-LLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 784
P + W K+ + +TE F ++ L I D+ D G+Y C N+ G N+ L+V
Sbjct: 540 PIITWNKEG--VQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597
Score = 90.1 bits (222), Expect = 1e-17
Identities = 97/414 (23%), Positives = 162/414 (39%), Gaps = 65/414 (15%)
Query: 391 LILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDC 450
L L+ NRIR I AF L L L L++N I + NAF ++ L L+L + +
Sbjct: 55 LDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALD 114
Query: 451 QLKWLPQWVAENNFQSFVNASCAHPQ----LLKGRSIFAVSPDGFVCDDFPKPQITVQPE 506
+ + E+ + F P+ LL+ +F
Sbjct: 115 KQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLF---------------------- 152
Query: 507 TQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEM-------ENYA-HLRAQGGE 558
+ + LS I + + S+ + N L+ D ++ + +A H Q
Sbjct: 153 ----LHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAA 208
Query: 559 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 618
EY L R V + ++ C P T P D+ + +G
Sbjct: 209 TCEYPRRLHGRAVASVTVEEFNC-------------------QSPRITFEPQDVEVPSGN 249
Query: 619 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 678
C A G+P P+I W + + + R++V +D I + + D GVY C A
Sbjct: 250 TVYFTCRAEGNPKPEIIWIHNNHS-LDLEDDTRLNVF-DDGTLMIRNTRESDQGVYQCMA 307
Query: 679 QNSAGSISANATL----TVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDD 734
+NSAG + + ++ PSF+ D V G + L+C+A G P P + WT+D+
Sbjct: 308 RNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDN 367
Query: 735 SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788
+ RH A + L + + D G++TC +N+ GT + + V P
Sbjct: 368 GLELDGSRH--VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPP 419
Score = 68.9 bits (167), Expect = 2e-11
Identities = 51/162 (31%), Positives = 81/162 (50%), Gaps = 5/162 (3%)
Query: 46 PCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKL 105
PCP+ C C + C L +P+ +P LDL NR+ I S+ L++L + L
Sbjct: 23 PCPSRCLCFKSTVRCMHLMLDHIPQ-VPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLL 81
Query: 106 NNNELETIP-NLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ--T 162
NNN + I N N+ L L N I + + K SLE L + N + LQ T
Sbjct: 82 NNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPET 141
Query: 163 AFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRI 204
L+L+ L+L++N+++ + G F NL ++L L+L+ N +
Sbjct: 142 FGDLLRLERLFLHNNKLSKIPAGSFSNL-DSLKRLRLDSNAL 182
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 179 bits (455), Expect = 1e-44
Identities = 139/474 (29%), Positives = 236/474 (49%), Gaps = 24/474 (5%)
Query: 47 CPTTCRCL-GDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKL 105
CP+ C C ++C+ R+ +P PLP L + + ++ + S ++ +L +++
Sbjct: 31 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 90
Query: 106 NNNELETIP-----NLGPVSANITLLSLAGNRIVEILPEHLKE-FQSLETLDLSSNNISE 159
NEL I NLG ++ LSLA N++ ++LP L + SLE+L LSSN + +
Sbjct: 91 EKNELSRITPGAFRNLG----SLRYLSLANNKL-QVLPIGLFQGLDSLESLLLSSNQLLQ 145
Query: 160 LQTAF--PALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQ 216
+Q A LK L L+ N + + G FD+L L L L +N ++ I P++F+ L
Sbjct: 146 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVG-LTKLNLGKNSLTHISPRVFQHLGN 204
Query: 217 LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLT 276
LQ L L N++ ++ TF GL L+ L +Q+N + L G F N++ L L +N+++
Sbjct: 205 LQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHIS 264
Query: 277 EITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSL 336
++ L L L L N++ +S + L EL L NH+S L D+ F L
Sbjct: 265 QLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 324
Query: 337 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNG-AFSGLDKLRRLILQG 395
L L + N++S+I+ AF GL+ L+ L L N ++D++G F L L+ + LQ
Sbjct: 325 LQVLILSRNQISFISPGAFNGLTELRELSLHTN----ALQDLDGNVFRMLANLQNISLQN 380
Query: 396 NRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWL 455
NR+R + F ++ L + L +N + +L F + KL +L L + CD + L
Sbjct: 381 NRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPL 440
Query: 456 PQWVAENNFQSFVNA--SCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPET 507
W+ N + + C P ++G+S+ ++ + V P++ PET
Sbjct: 441 RNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAV-PSVHVPEVPSYPET 493
Score = 119 bits (298), Expect = 2e-26
Identities = 100/335 (29%), Positives = 161/335 (48%), Gaps = 12/335 (3%)
Query: 45 RPCPTTCRCLGDL--LDCSRKRLARLPEPLPSWVARLD---LSHNRLSFIKASSMSHLQS 99
R P R LG L L + +L LP L + L+ LS N+L I+ + S +
Sbjct: 97 RITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSN 156
Query: 100 LREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNI 157
L+E++L+ N LE IP+ G +T L+L N + I P + +L+ L L N +
Sbjct: 157 LKELQLHGNHLEYIPD-GAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 215
Query: 158 SELQ--TAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KL 214
+++ T + L+ L L N++ + PG F N N L L L+ N IS +PP +F +L
Sbjct: 216 TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHN-LQRLYLSNNHISQLPPSIFMQL 274
Query: 215 PQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNN 274
PQL L L N +K + F + L+ L + N ++ L D F L +++L L N
Sbjct: 275 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQ 334
Query: 275 LTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGL 334
++ I+ G GL L+EL L NA+ + + + L + L N L +L + F +
Sbjct: 335 ISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV 394
Query: 335 SLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 369
+ L + + NN++ + F L L L L +N
Sbjct: 395 NGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 179 bits (455), Expect = 1e-44
Identities = 139/474 (29%), Positives = 236/474 (49%), Gaps = 24/474 (5%)
Query: 47 CPTTCRCL-GDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKL 105
CP+ C C ++C+ R+ +P PLP L + + ++ + S ++ +L +++
Sbjct: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
Query: 106 NNNELETIP-----NLGPVSANITLLSLAGNRIVEILPEHLKE-FQSLETLDLSSNNISE 159
NEL I NLG ++ LSLA N++ ++LP L + SLE+L LSSN + +
Sbjct: 85 EKNELSRITPGAFRNLG----SLRYLSLANNKL-QVLPIGLFQGLDSLESLLLSSNQLLQ 139
Query: 160 LQTAF--PALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQ 216
+Q A LK L L+ N + + G FD+L L L L +N ++ I P++F+ L
Sbjct: 140 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVG-LTKLNLGKNSLTHISPRVFQHLGN 198
Query: 217 LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLT 276
LQ L L N++ ++ TF GL L+ L +Q+N + L G F N++ L L +N+++
Sbjct: 199 LQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHIS 258
Query: 277 EITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSL 336
++ L L L L N++ +S + L EL L NH+S L D+ F L
Sbjct: 259 QLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 318
Query: 337 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNG-AFSGLDKLRRLILQG 395
L L + N++S+I+ AF GL+ L+ L L N ++D++G F L L+ + LQ
Sbjct: 319 LQVLILSRNQISFISPGAFNGLTELRELSLHTN----ALQDLDGNVFRMLANLQNISLQN 374
Query: 396 NRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWL 455
NR+R + F ++ L + L +N + +L F + KL +L L + CD + L
Sbjct: 375 NRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPL 434
Query: 456 PQWVAENNFQSFVNA--SCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPET 507
W+ N + + C P ++G+S+ ++ + V P++ PET
Sbjct: 435 RNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAV-PSVHVPEVPSYPET 487
Score = 119 bits (298), Expect = 2e-26
Identities = 100/335 (29%), Positives = 161/335 (48%), Gaps = 12/335 (3%)
Query: 45 RPCPTTCRCLGDL--LDCSRKRLARLPEPLPSWVARLD---LSHNRLSFIKASSMSHLQS 99
R P R LG L L + +L LP L + L+ LS N+L I+ + S +
Sbjct: 91 RITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSN 150
Query: 100 LREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNI 157
L+E++L+ N LE IP+ G +T L+L N + I P + +L+ L L N +
Sbjct: 151 LKELQLHGNHLEYIPD-GAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 209
Query: 158 SELQ--TAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KL 214
+++ T + L+ L L N++ + PG F N N L L L+ N IS +PP +F +L
Sbjct: 210 TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHN-LQRLYLSNNHISQLPPSIFMQL 268
Query: 215 PQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNN 274
PQL L L N +K + F + L+ L + N ++ L D F L +++L L N
Sbjct: 269 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQ 328
Query: 275 LTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGL 334
++ I+ G GL L+EL L NA+ + + + L + L N L +L + F +
Sbjct: 329 ISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV 388
Query: 335 SLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 369
+ L + + NN++ + F L L L L +N
Sbjct: 389 NGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 164 bits (414), Expect = 6e-40
Identities = 142/477 (29%), Positives = 219/477 (45%), Gaps = 43/477 (9%)
Query: 5 SLRARAAGLGLLLCAVLGRAGRSDSGGR-GELGQPSGVAAERPCPTTCRCLGD------L 57
+LR L LLL + + RS G G G+ G A CP C C D
Sbjct: 2 ALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPA----CPAACVCSYDDDADELS 57
Query: 58 LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNL 116
+ CS + L RLP+ +P L L N LS + ++ +L SL + L +L ++ P
Sbjct: 58 VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQA 117
Query: 117 GPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ--------------- 161
N+ L L N++ + +L +L LS+N +S L+
Sbjct: 118 LLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNL 177
Query: 162 ----------TAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK 210
AF L L+ L L NR+ ++P F LA L L L+RN + AI
Sbjct: 178 GWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE-LRELDLSRNALRAIKAN 236
Query: 211 MF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQ 269
+F +LP+LQ L L+RN I V F GL AL+ L + N V L++ F GL + +L+
Sbjct: 237 VFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLR 296
Query: 270 LDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDS 329
L HN + + L L+EL L N I +++ ++E +L L L N L +
Sbjct: 297 LSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAG 356
Query: 330 SFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLR 389
+FLGL+ + +++ N + + + FRGL L +L L+ + + F+GL LR
Sbjct: 357 AFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG---RIRPHTFTGLSGLR 413
Query: 390 RLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
RL L+ N + I +++ GL L LDL+ N + L F + KL+ L L+ + L
Sbjct: 414 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 470
Score = 143 bits (360), Expect = 1e-33
Identities = 122/426 (28%), Positives = 200/426 (46%), Gaps = 36/426 (8%)
Query: 76 VARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIV 134
+A L LS+NRLS ++ L SL ++ L N L +P+ ++ L LAGNR+
Sbjct: 148 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 207
Query: 135 EILPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLAN 192
+ P L LDLS N + ++ F L +L+ LYL+ N + ++ PG F L
Sbjct: 208 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 267
Query: 193 T-----------------------LLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIK 228
L VL+L+ N I+++ P+ FK L L+ L+L N+I+
Sbjct: 268 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
Query: 229 NVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLM 288
+ +F+GLG L+ L + N + ++ GAF GL+N+ ++ L N L + + GL
Sbjct: 328 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 387
Query: 289 LQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVS 348
L LHL + + RI P + L L L N L +++ S GL+ L L + +N+++
Sbjct: 388 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 447
Query: 349 YIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTG 408
++ F+GL L+ L L N ++ D A L + L + NR+ ++
Sbjct: 448 HLPHRLFQGLGKLEYLLLSRNRLAELPAD---ALGPLQRAFWLDVSHNRLEALPNSLLAP 504
Query: 409 LDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN--NFQS 466
L L +L L +N++ + Q L++L L + C C LK L + +N
Sbjct: 505 LGRLRYLSLRNNSLRTFT----PQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPR 560
Query: 467 FVNASC 472
FV A C
Sbjct: 561 FVQAIC 566
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 162 bits (409), Expect = 2e-39
Identities = 141/474 (29%), Positives = 217/474 (45%), Gaps = 43/474 (9%)
Query: 8 ARAAGLGLLLCAVLGRAGRSDSGGR-GELGQPSGVAAERPCPTTCRCLGD------LLDC 60
A L LLL + + RS G G G+ G A CP C C D + C
Sbjct: 43 AGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPA----CPAACVCSYDDDADELSVFC 98
Query: 61 SRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPV 119
S + L RLP+ +P L L N LS + ++ +L SL + L +L ++ P
Sbjct: 99 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 158
Query: 120 SANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ------------------ 161
N+ L L N++ + +L +L LS+N +S L+
Sbjct: 159 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 218
Query: 162 -------TAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF- 212
AF L L+ L L NR+ ++P F LA L L L+RN + AI +F
Sbjct: 219 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE-LRELDLSRNALRAIKANVFV 277
Query: 213 KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDH 272
+LP+LQ L L+RN I V F GL AL+ L + N V L++ F GL + +L+L H
Sbjct: 278 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 337
Query: 273 NNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFL 332
N + + L L+EL L N I +++ ++E +L L L N L + +FL
Sbjct: 338 NAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFL 397
Query: 333 GLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLI 392
GL+ + +++ N + + + FRGL L +L L+ + + F+GL LRRL
Sbjct: 398 GLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG---RIRPHTFTGLSGLRRLF 454
Query: 393 LQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
L+ N + I +++ GL L LDL+ N + L F + KL+ L L+ + L
Sbjct: 455 LKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 508
Score = 143 bits (360), Expect = 1e-33
Identities = 122/426 (28%), Positives = 200/426 (46%), Gaps = 36/426 (8%)
Query: 76 VARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIV 134
+A L LS+NRLS ++ L SL ++ L N L +P+ ++ L LAGNR+
Sbjct: 186 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 245
Query: 135 EILPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLAN 192
+ P L LDLS N + ++ F L +L+ LYL+ N + ++ PG F L
Sbjct: 246 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 305
Query: 193 T-----------------------LLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIK 228
L VL+L+ N I+++ P+ FK L L+ L+L N+I+
Sbjct: 306 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 365
Query: 229 NVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLM 288
+ +F+GLG L+ L + N + ++ GAF GL+N+ ++ L N L + + GL
Sbjct: 366 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 425
Query: 289 LQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVS 348
L LHL + + RI P + L L L N L +++ S GL+ L L + +N+++
Sbjct: 426 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 485
Query: 349 YIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTG 408
++ F+GL L+ L L N ++ D A L + L + NR+ ++
Sbjct: 486 HLPHRLFQGLGKLEYLLLSRNRLAELPAD---ALGPLQRAFWLDVSHNRLEALPNSLLAP 542
Query: 409 LDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN--NFQS 466
L L +L L +N++ + Q L++L L + C C LK L + +N
Sbjct: 543 LGRLRYLSLRNNSLRTFT----PQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPR 598
Query: 467 FVNASC 472
FV A C
Sbjct: 599 FVQAIC 604
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 155 bits (391), Expect = 3e-37
Identities = 158/499 (31%), Positives = 240/499 (48%), Gaps = 37/499 (7%)
Query: 128 LAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQ--LKYLYLNSNRVTSMEPG 185
L G+R +E +P L E LDLS N + LQ + L+ L L+ N+++++EPG
Sbjct: 45 LCGHRQLEAVPGGLP--LDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPG 102
Query: 186 YFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSL 244
F L +LL L+L NR+ + P +F L L L+L N+I F LG+L+ L
Sbjct: 103 AFHGL-QSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKL 161
Query: 245 KMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISP 304
++ N + + GAF GL+ + L L+ NL+ + L L L L L + I R+
Sbjct: 162 EVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPA 221
Query: 305 DAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 363
A +L EL++ + L LD S +GL+L ++L I +S + A LS L+
Sbjct: 222 GALRGLGQLKELEIHLWPSLEALDPGSLVGLNL-SSLAITRCNLSSVPFQALYHLSFLRV 280
Query: 364 LDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIM 423
LDL N IS S L +L+ L L G + SI AF GL A LD++DNA+
Sbjct: 281 LDLSQNPISAIPARR---LSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQ 337
Query: 424 SLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 483
+L+ AF KL L L+ + L CDC+L WL + +F +CA P ++G+S+
Sbjct: 338 TLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDF-GMSPPACAGPHHVQGKSL 396
Query: 484 FAVS----PDGFVCDDFPKPQITVQ--PETQSAIKGSNLSFICSAASSSDSPMTFAWKKD 537
S P F C KP + + P A +G + F CS D T +W +
Sbjct: 397 KEFSDILPPGHFTC----KPALIRKSGPRWVIAEEGGHAVFSCS--GDGDPAPTVSWMRP 450
Query: 538 NELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKL 597
H A + +R V+E T L +R V+ G Y CV+SN G+ S++ L
Sbjct: 451 ----HGAWLGRAGRVR-----VLEDGT-LEIRSVQLRDRGAYVCVVSNVAGND-SLRTWL 499
Query: 598 TVNML--PSFTKTPMDLTI 614
V + P+ T + ++T+
Sbjct: 500 EVIQVEPPNGTLSDPNITV 518
Score = 112 bits (279), Expect = 3e-24
Identities = 103/333 (30%), Positives = 155/333 (46%), Gaps = 9/333 (2%)
Query: 47 CPTTCRCLGD--LLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVK 104
CP C C + C ++L +P LP LDLS NRL ++ +S L L+E+
Sbjct: 31 CPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELD 90
Query: 105 LNNNELETI-PNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNI-SELQT 162
L+ N+L T+ P ++ L L GNR+ + P +L LDL N I L
Sbjct: 91 LSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDG 150
Query: 163 AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPP-KMFKLPQLQHL 220
AF L L+ L + N + + PG F LA L L L R +S +P + +LP L L
Sbjct: 151 AFGELGSLQKLEVGDNHLVFVAPGAFAGLAK-LSTLTLERCNLSTVPGLALARLPALVAL 209
Query: 221 ELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD-GAFWGLSNMEILQLDHNNLTEIT 279
L I + +GLG LK L++ + +D G+ GL N+ L + NL+ +
Sbjct: 210 RLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGL-NLSSLAITRCNLSSVP 268
Query: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 339
LY L L+ L LSQN I+ I +L EL L+ L+ + +F GL+ +
Sbjct: 269 FQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHL 328
Query: 340 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEIS 372
L + +N + + + AF L TL L N ++
Sbjct: 329 LDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361
Score = 94.4 bits (233), Expect = 6e-19
Identities = 125/478 (26%), Positives = 185/478 (38%), Gaps = 57/478 (11%)
Query: 266 EILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSR 325
E+L L N L + +G L L +LQEL LS N ++ + P A+ Q L L L N L
Sbjct: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122
Query: 326 LDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGL 385
+ F GLS L L + N++ D AF L SL+ L++ +N + + GAF+GL
Sbjct: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAP---GAFAGL 179
Query: 386 DKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLH----- 440
KL L L+ + ++ A L AL L L + I L A + +L++L
Sbjct: 180 AKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWP 239
Query: 441 ------------LNTSSL-LCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVS 487
LN SSL + C L +P FQ+ + S L I A+
Sbjct: 240 SLEALDPGSLVGLNLSSLAITRCNLSSVP-------FQALYHLSFLRVLDLSQNPISAIP 292
Query: 488 PDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEM- 546
P + +Q + + G+ L+ I + A + DN L E
Sbjct: 293 ARRL------SPLVRLQ---ELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETA 343
Query: 547 ----ENYAHLRAQGGEVM---EYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV 599
+ LR G + +LRLR C +H S+K +
Sbjct: 344 FPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGK-SLKEFSDI 402
Query: 600 NMLPSFT--------KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERR 651
FT P + G A C+ G PAP ++W + G R R
Sbjct: 403 LPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL--GRAGR 460
Query: 652 MHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVT 709
+ V+ ED I V++ D G Y C N AG+ S L V++ L D +T
Sbjct: 461 VRVL-EDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNIT 517
Score = 39.7 bits (91), Expect = 0.016
Identities = 25/95 (26%), Positives = 36/95 (37%), Gaps = 4/95 (4%)
Query: 710 KGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEM 769
+G AV C G P P ++W + + + L I + D G Y C +
Sbjct: 427 EGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVV 486
Query: 770 SNTLGTERGNVRLSVI----PTPTCDSPQMTAPSL 800
SN G + L VI P T P +T P +
Sbjct: 487 SNVAGNDSLRTWLEVIQVEPPNGTLSDPNITVPGI 521
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 153 bits (387), Expect = 8e-37
Identities = 154/525 (29%), Positives = 232/525 (44%), Gaps = 56/525 (10%)
Query: 101 REVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 160
+ V + L IP P+ I L L+ NR+ + PE + LE +DLS N I+
Sbjct: 39 KSVSCHRRRLIAIPEGIPIETKI--LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIA-- 94
Query: 161 QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQH 219
++EPG F+NL N L L+L NR+ +P +F L L
Sbjct: 95 --------------------NVEPGAFNNLFN-LRSLRLKGNRLKLVPLGVFTGLSNLTK 133
Query: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279
L+++ NKI + FQ L LKSL++ N + + AF GL ++E L L+ NLT +
Sbjct: 134 LDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVP 193
Query: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTF-NHLSRLDDSSFLGLSLLN 338
L L L LHL IN + A++ L L++ + L + +S GL+L
Sbjct: 194 TEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNL-T 252
Query: 339 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 398
+L + N +S + AF+ L L L+L N IS TIE G FS L +L+ L + G ++
Sbjct: 253 SLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPIS-TIEA--GMFSDLIRLQELHIVGAQL 309
Query: 399 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 458
R+I +F GL L L++S N + +L+ N FS + L+ L +N + L CDC+L W+ Q
Sbjct: 310 RTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQR 369
Query: 459 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDG----FVCDDFPKPQITVQPETQSAI-KG 513
F CA P ++ RS F C KP+I + + +G
Sbjct: 370 QPTLQFGG-QQPMCAGPDTIRERSFKDFHSTALSFYFTC---KKPKIREKKLQHLLVDEG 425
Query: 514 SNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEF 573
+ CSA D +W + A + G L +R +
Sbjct: 426 QTVQLECSA--DGDPQPVISWVTPRRRFITTKSNGRATVLGDG--------TLEIRFAQD 475
Query: 574 ASEGKYQCVISNHFGSSYSVKAKLTVNMLPS-----FTKTPMDLT 613
G Y C+ SN G+ + A LTV S +TPM +T
Sbjct: 476 QDSGMYVCIASNAAGND-TFTASLTVKGFASDRFLYANRTPMYMT 519
Score = 98.6 bits (244), Expect = 3e-20
Identities = 89/340 (26%), Positives = 151/340 (44%), Gaps = 23/340 (6%)
Query: 47 CPTTCRCLGD--LLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVK 104
CP C C + C R+RL +PE +P LDLS NRL + L E+
Sbjct: 28 CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEID 87
Query: 105 LNNNELETI-PNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTA 163
L++N + + P N+ L L GNR+ + +L LD+S N I
Sbjct: 88 LSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKI------ 141
Query: 164 FPALQLKYLYLNSNRVTSMEPG-----YFDNLANTLLV----LKLNRNRISAIPPK-MFK 213
+ L Y++ + + + S+E G Y + A + L+ L L + ++A+P + +
Sbjct: 142 --VILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSH 199
Query: 214 LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD-GAFWGLSNMEILQLDH 272
L L L L I N+ F+ L LK L++ + +M + +GL N+ L + +
Sbjct: 200 LRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGL-NLTSLSVTN 258
Query: 273 NNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFL 332
NL+ + L+ L L+LS N I+ I + +L EL + L ++ SF
Sbjct: 259 TNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQ 318
Query: 333 GLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEIS 372
GL L L++ N + + + F +L+ L + NN ++
Sbjct: 319 GLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLA 358
Score = 42.0 bits (97), Expect = 0.003
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 1/82 (1%)
Query: 612 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 671
L + G +LEC+A G P P I+W R V+ D I + +D
Sbjct: 420 LLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLG-DGTLEIRFAQDQDS 478
Query: 672 GVYSCTAQNSAGSISANATLTV 693
G+Y C A N+AG+ + A+LTV
Sbjct: 479 GMYVCIASNAAGNDTFTASLTV 500
Score = 41.2 bits (95), Expect = 0.006
Identities = 24/79 (30%), Positives = 37/79 (46%), Gaps = 2/79 (2%)
Query: 708 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAA--GNQLLIIVDSDVSDAGKY 765
V +G+T L+C A G P P ++W + T+ + A G+ L I + D+G Y
Sbjct: 422 VDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMY 481
Query: 766 TCEMSNTLGTERGNVRLSV 784
C SN G + L+V
Sbjct: 482 VCIASNAAGNDTFTASLTV 500
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 149 bits (375), Expect = 2e-35
Identities = 148/514 (28%), Positives = 234/514 (45%), Gaps = 47/514 (9%)
Query: 101 REVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 160
R V L +P+ + A LL L+ NRI + P L +LE LDLS N I+ +
Sbjct: 36 RAVACTRRRLTAVPD--GIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHV 93
Query: 161 QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQH 219
EPG F NL L VL+L N++ IPP +F +L L
Sbjct: 94 ----------------------EPGAFANLPR-LRVLRLRGNQLKLIPPGVFTRLDNLTL 130
Query: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279
L+L+ NK+ + TFQ L +L+ L++ N + + AF GL +E L L+ NLT ++
Sbjct: 131 LDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALS 190
Query: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSLLN 338
L L L L L AI + + L L++ + L + S GL+L
Sbjct: 191 GESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNL-T 249
Query: 339 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 398
+L + + ++ + A R + L L+L +N IS G+F L +LR L L G +
Sbjct: 250 SLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTV---PRGSFRDLVRLRELHLAGALL 306
Query: 399 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 458
+ +AF GL + L+LS+N + +L+ + F + L+ L ++ + L CDC+L W+ Q
Sbjct: 307 AVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQR 366
Query: 459 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDF--PKPQITVQP-ETQSAIKGSN 515
NF + A CA P ++G ++ + PD + + F KP+I + + +A G +
Sbjct: 367 RKTLNFDGRLPA-CATPAEVRGDALRNL-PDSVLFEYFVCRKPKIRERRLQRVTATAGED 424
Query: 516 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 575
+ F+C A + T AW A A + G L +++
Sbjct: 425 VRFLCRA--EGEPAPTVAWVTPQHRPVTATSAGRARVLPGG--------TLEIQDARPQD 474
Query: 576 EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP 609
G Y CV SN G + + A LTV P+ +TP
Sbjct: 475 SGTYTCVASN-AGGNDTYFATLTVRPEPAANRTP 507
Score = 107 bits (267), Expect = 6e-23
Identities = 90/338 (26%), Positives = 169/338 (50%), Gaps = 35/338 (10%)
Query: 47 CPTTCRCLGDL--LDCSRKRLARLPEPLPS------------------------WVARLD 80
CP C C + C+R+RL +P+ +P+ + LD
Sbjct: 25 CPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELD 84
Query: 81 LSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILPE 139
LS N ++ ++ + ++L LR ++L N+L+ I P + N+TLL L+ N++V +L
Sbjct: 85 LSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDY 144
Query: 140 HLKEFQSLETLDLSSNNISEL-QTAFPA-LQLKYLYLNSNRVTSMEPGYFDNLANTLLVL 197
++ SL L++ N++ + + AF L L+ L L +T++ +L +L L
Sbjct: 145 TFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHL-RSLGAL 203
Query: 198 KLNRNRISAIPPKMF-KLPQLQHLEL-NRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 255
+L I+++ + F +LP L HLE+ N ++ V + +GL L SL + +T +
Sbjct: 204 RLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLN-LTSLSVTHTNITAVP 262
Query: 256 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 315
A +++ L L HN ++ + +G L+ L+ELHL+ + + P A+ +++
Sbjct: 263 AAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRL 322
Query: 316 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADC 353
L+L+ N LS L++S+F ++ L TL + N ++ DC
Sbjct: 323 LNLSNNLLSTLEESTFHSVNTLETLRVDGNPLA--CDC 358
Score = 52.4 bits (124), Expect = 2e-06
Identities = 31/87 (35%), Positives = 41/87 (47%), Gaps = 1/87 (1%)
Query: 612 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 671
+T AG R C A G PAP +AW A R V+P I D + +D
Sbjct: 417 VTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLP-GGTLEIQDARPQDS 475
Query: 672 GVYSCTAQNSAGSISANATLTVLETPS 698
G Y+C A N+ G+ + ATLTV P+
Sbjct: 476 GTYTCVASNAGGNDTYFATLTVRPEPA 502
Score = 40.0 bits (92), Expect = 0.012
Identities = 30/88 (34%), Positives = 37/88 (42%), Gaps = 4/88 (4%)
Query: 707 TVTKGETAVLQCIAGGSPPPKLNW-TKDDSPLVVTE--RHFFAAGNQLLIIVDSDVSDAG 763
T T GE C A G P P + W T P+ T R G L I D+ D+G
Sbjct: 418 TATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEI-QDARPQDSG 476
Query: 764 KYTCEMSNTLGTERGNVRLSVIPTPTCD 791
YTC SN G + L+V P P +
Sbjct: 477 TYTCVASNAGGNDTYFATLTVRPEPAAN 504
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 147 bits (370), Expect = 7e-35
Identities = 139/456 (30%), Positives = 215/456 (47%), Gaps = 35/456 (7%)
Query: 2 SAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLL--- 58
S P LRA L LCA L + R+ G P CP C C D +
Sbjct: 3 SPPGLRA------LWLCAALCASRRAG-------GAPQPGPGPTACPAPCHCQEDGIMLS 49
Query: 59 -DCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLG 117
DCS L+ +P L A LDLS N L+ ++ HL+ L E++L+ N L IP
Sbjct: 50 ADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQA 109
Query: 118 PVSA-NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LKYLYL 174
++ +L L N++ I E L E SL++L L +N IS + + +F L L++L+L
Sbjct: 110 FSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWL 169
Query: 175 NSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGL 233
+ N +T + +NL L + L NRIS IP F+ L L L L+ N+I+++
Sbjct: 170 DDNALTEIPVRALNNLP-ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 228
Query: 234 TFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELH 293
+F+GL L++L + N + + A L ++ L +NN+ I + G +LQ +H
Sbjct: 229 SFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 287
Query: 294 LSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSF---LGLSLLNTLHIGNNRVSYI 350
N I + A+++ KL L L +D F G + L L + + +
Sbjct: 288 FYDNPIQFVGRSAFQYLPKLHTLSLN----GAMDIQEFPDLKGTTSLEILTLTRAGIRLL 343
Query: 351 ADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLD 410
+ L L+ L+L +N+I E++ + KL + LQ NRI I F+ L
Sbjct: 344 PSGMCQQLPRLRVLELSHNQI----EELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLS 398
Query: 411 ALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
+L+ LDLS NAI S+ AFS + L +L L + L
Sbjct: 399 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL 434
Score = 58.5 bits (140), Expect = 3e-08
Identities = 67/247 (27%), Positives = 110/247 (44%), Gaps = 32/247 (12%)
Query: 79 LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP----------NLGPVSANITLL-- 126
L L +NR+ + S L +L + LN N+L+ P LG + NI +
Sbjct: 215 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPE 274
Query: 127 -SLAGNRIVEILPEH--------LKEFQSLETLD-LSSNNISELQTAFPALQ----LKYL 172
+ GN +++ + + FQ L L LS N ++Q FP L+ L+ L
Sbjct: 275 KAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE-FPDLKGTTSLEIL 333
Query: 173 YLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDG 232
L + + G L L VL+L+ N+I +P + + +L+ + L N+I +
Sbjct: 334 TLTRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGA 391
Query: 233 LTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQ-- 290
TF L +L++L + N + + AF L ++ L L N LT + L GL+ L+
Sbjct: 392 DTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLK 451
Query: 291 -ELHLSQ 296
L LSQ
Sbjct: 452 GNLALSQ 458
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 145 bits (366), Expect = 2e-34
Identities = 141/466 (30%), Positives = 225/466 (48%), Gaps = 43/466 (9%)
Query: 150 LDLSSNNISELQ----TAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRIS 205
LDL N I L +FP L+ L LN N V+++EPG F+NL N L L L NR+
Sbjct: 76 LDLGKNRIKTLNQDEFASFP--HLEELELNENIVSAVEPGAFNNLFN-LRTLGLRSNRLK 132
Query: 206 AIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSN 264
IP +F L L L+++ NKI + FQ L LKSL++ N + + AF GL++
Sbjct: 133 LIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNS 192
Query: 265 MEILQLDHNNLTEITK---GWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLT-F 320
+E L L+ NLT I L+GL++L+ HL+ NAI S ++ +L L+++ +
Sbjct: 193 LEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYS---FKRLYRLKVLEISHW 249
Query: 321 NHLSRLDDSSFLGLSL--LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDM 378
+L + + GL+L L+ H V Y+A R L L+ L+L N IS TIE
Sbjct: 250 PYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLA---VRHLVYLRFLNLSYNPIS-TIE-- 303
Query: 379 NGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQ 438
L +L+ + L G ++ + AF GL+ L L++S N + +L+ + F + L+
Sbjct: 304 GSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLET 363
Query: 439 LHLNTSSLLCDCQLKWL--PQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDF 496
L L+++ L CDC+L W+ +W N Q +CA P+ ++G+ F PD + + F
Sbjct: 364 LILDSNPLACDCRLLWVFRRRWRLNFNRQ---QPTCATPEFVQGKE-FKDFPDVLLPNYF 419
Query: 497 PKPQITVQPETQSAI---KGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLR 553
+ ++ + +G + F+C A D P W + L A+ +
Sbjct: 420 TCRRARIRDRKAQQVFVDEGHTVQFVCRA--DGDPPPAILWLSPRKHLVSAKSNGRLTVF 477
Query: 554 AQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV 599
G L +R + G Y C+ +N G + S+ A L V
Sbjct: 478 PDG--------TLEVRYAQVQDNGTYLCIAAN-AGGNDSMPAHLHV 514
Score = 100 bits (249), Expect = 8e-21
Identities = 91/333 (27%), Positives = 152/333 (45%), Gaps = 9/333 (2%)
Query: 47 CPTTCRCLGD--LLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVK 104
CP C C + C RKR +PE +P+ LDL NR+ + + L E++
Sbjct: 42 CPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELE 101
Query: 105 LNNNELETI-PNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNI-SELQT 162
LN N + + P N+ L L NR+ I +L LD+S N I L
Sbjct: 102 LNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDY 161
Query: 163 AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK-MFKLPQLQHL 220
F L LK L + N + + F L N+L L L + +++IP + + L L L
Sbjct: 162 MFQDLYNLKSLEVGDNDLVYISHRAFSGL-NSLEQLTLEKCNLTSIPTEALSHLHGLIVL 220
Query: 221 ELNRNKIKNVDGLTFQGLGALKSLKMQR-NGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279
L I + +F+ L LK L++ + + +GL N+ L + H NLT +
Sbjct: 221 RLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGL-NLTSLSITHCNLTAVP 279
Query: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 339
+ L+ L+ L+LS N I+ I +L E+ L L+ ++ +F GL+ L
Sbjct: 280 YLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRV 339
Query: 340 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEIS 372
L++ N+++ + + F + +L+TL L +N ++
Sbjct: 340 LNVSGNQLTTLEESVFHSVGNLETLILDSNPLA 372
Score = 76.6 bits (187), Expect = 1e-13
Identities = 105/470 (22%), Positives = 176/470 (37%), Gaps = 73/470 (15%)
Query: 267 ILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRL 326
+L L N + + + L+EL L++N ++ + P A+ L L L N L +
Sbjct: 75 LLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLI 134
Query: 327 DDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLD 386
F GLS L L I N++ + D F+ L +LK+L++ +N++ + + AFSGL+
Sbjct: 135 PLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYI---SHRAFSGLN 191
Query: 387 KLRRLILQGNRIRSITKKAFT---GLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLH--- 440
L +L L+ + SI +A + GL L L+ NAI ++K L+ H
Sbjct: 192 SLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPY 251
Query: 441 -----------LNTSSL-LCDCQLKWLPQWVAEN-----------NFQSFVNASCAHPQL 477
LN +SL + C L +P + N S + S H L
Sbjct: 252 LDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELL 311
Query: 478 ------LKGRSIFAVSPDGF-------VCDDFPKPQITVQPETQSAIKGSNLSFICSAAS 524
L G + V P F V + T++ ++ + S
Sbjct: 312 RLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371
Query: 525 SSDSPMTFAWKKDNELLHDAEMENYAHLR-AQGGEVMEYTTILRLREVEFASEGKYQCVI 583
+ D + + +++ L + + A QG E ++ +L +
Sbjct: 372 ACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVL----------------L 415
Query: 584 SNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTD 643
N+F T + + + G + C A G P P I W
Sbjct: 416 PNYF----------TCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHL 465
Query: 644 FPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTV 693
A R+ V P D + +++D G Y C A N+ G+ S A L V
Sbjct: 466 VSAKSNGRLTVFP-DGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV 514
Score = 36.2 bits (82), Expect = 0.18
Identities = 18/58 (31%), Positives = 34/58 (58%)
Query: 389 RRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
R L L NRI+++ + F LE L+L++N + +++ AF+ + L+ L L ++ L
Sbjct: 74 RLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRL 131
Score = 32.3 bits (72), Expect = 2.6
Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 6/81 (7%)
Query: 708 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERH----FFAAGNQLLIIVDSDVSDAG 763
V +G T C A G PPP + W LV + + F G L + + V D G
Sbjct: 436 VDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGT--LEVRYAQVQDNG 493
Query: 764 KYTCEMSNTLGTERGNVRLSV 784
Y C +N G + L V
Sbjct: 494 TYLCIAANAGGNDSMPAHLHV 514
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 145 bits (365), Expect = 3e-34
Identities = 124/453 (27%), Positives = 206/453 (45%), Gaps = 31/453 (6%)
Query: 45 RPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVK 104
+PCP C C + CS + LA +P +P + + F++ S +
Sbjct: 20 QPCPMGCDCFVQEVFCSDEELATVPLDIPPYT-------KNIIFVETSFTT--------- 63
Query: 105 LNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT-A 163
L + PNL T + ++ + P+ LE L+++ ++ L T
Sbjct: 64 LETRAFGSNPNL-------TKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNI 116
Query: 164 FPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLE 221
F L L L LN N + ++ G F +LA L L L N++ A+P ++F+ L L+ L
Sbjct: 117 FSNLTSLGKLTLNFNMLEALPEGLFQHLA-ALESLHLQGNQLQALPRRLFQPLTHLKTLN 175
Query: 222 LNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKG 281
L +N + + F L +L++LK+ N ++ L G F L +++ L LD NN++E+
Sbjct: 176 LAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQ 235
Query: 282 WLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLH 341
L L+ L L +NAI + + L+ L L +N L L F L L
Sbjct: 236 VFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLS 295
Query: 342 IGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSI 401
+ +N++ +A+ F LS+L++L L N I+ G F L++L +L L N + ++
Sbjct: 296 LTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPA---GIFRDLEELVKLYLGSNNLTAL 352
Query: 402 TKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAE 461
F L LE L LS N + +L F L L L+ + CDC L +L W+ +
Sbjct: 353 HPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQ 412
Query: 462 NNFQSF-VNASCAHPQLLKGRSIFAVSPDGFVC 493
+ + CA P LKG+ + A++ VC
Sbjct: 413 YTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVC 445
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 140 bits (353), Expect = 7e-33
Identities = 127/456 (27%), Positives = 212/456 (46%), Gaps = 27/456 (5%)
Query: 14 GLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCL-GDLLDCSRKRLARLPE-P 71
G LLCAVLG A PCP C+C+ D CS +AR+
Sbjct: 4 GTLLCAVLGLLR----------------AQPFPCPPACKCVFRDAAQCSGGDVARISALG 47
Query: 72 LPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAG 130
LP+ + + L +++ S S + L+ + ++++ + + P + L L+
Sbjct: 48 LPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSR 107
Query: 131 NRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFD 188
N+I + L + LE L L N + + Q F L L+ L LN N++ + F
Sbjct: 108 NKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFT 167
Query: 189 NLANTLLVLKLNRNRISAIPPKMFKLP-QLQHLELNRNKIKNVDGLTFQGLGALKSLKMQ 247
NL N L +L L+ N ++ +P + +L+ L L+ N++ ++D LGAL L+
Sbjct: 168 NLEN-LKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFH 226
Query: 248 RNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAW 307
RN + + GAF L N+ L L N+L + L L L +N + + +
Sbjct: 227 RNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLF 286
Query: 308 EFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIG-NNRVSYIADCAFRGLSSLKTLDL 366
L EL L L L ++F LS L L + + R+S + AF+GL L+ L L
Sbjct: 287 GEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLAL 346
Query: 367 KNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQ 426
+N ++ + D G GL KLR++ L+ NR+R++ + F L +LE + L N + +L
Sbjct: 347 HSNGLT-ALPD--GLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLP 403
Query: 427 GNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN 462
G+ F + +L ++ L +S CDC L W+ ++
Sbjct: 404 GDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQH 439
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 139 bits (350), Expect = 1e-32
Identities = 138/463 (29%), Positives = 206/463 (44%), Gaps = 71/463 (15%)
Query: 13 LGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDL-LDCSRKRLARLPEP 71
LGLL LG G + PSG AA C C C GD +DCS K L +PE
Sbjct: 5 LGLLCFLALGLLGSAG---------PSG-AAPPLCAAPCSCDGDRRVDCSGKGLTAVPEG 54
Query: 72 LPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGN 131
L ++ LD+S N ++ + + + L E L LAGN
Sbjct: 55 LSAFTQALDISMNNITQLPEDAFKNFPFLEE-----------------------LQLAGN 91
Query: 132 RIVEILPEHLKEFQSLETLDLSSNNI----SELQTAFPALQLKYLYLNSNRVTSMEPGYF 187
+ I P+ L + L+ L L +N + SE ALQ L L++N +TS+ F
Sbjct: 92 DLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQS--LRLDANHITSVPEDSF 149
Query: 188 DNLANTLLVLKLNRNRISAIPPK-MFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKM 246
+ L L L L+ N ++ +P + LP LQ L L NKI ++ F L +L L +
Sbjct: 150 EGLVQ-LRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHL 208
Query: 247 QRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDA 306
N + L F GL N+E L L++NNL E + + L L+EL N+I+ I A
Sbjct: 209 HNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQA-IKALPSLKELGFHSNSISVIPDGA 267
Query: 307 WEFCQKLSELDLTFNHLSRLDDSSFLGLS------------------LLNTLHIGN---- 344
++ L + L N LS + +S+F LS L T+H+ +
Sbjct: 268 FDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLT 327
Query: 345 -NRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITK 403
++S I + + L+TLDL N I D+ +F+G L + LQ N+I I +
Sbjct: 328 GTKISSIPNNLCQEQKMLRTLDLSYNNI----RDLP-SFNGCHALEEISLQRNQIYQIKE 382
Query: 404 KAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
F GL +L LDLS N I + AF+ + + L ++ + L
Sbjct: 383 GTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNEL 425
Score = 112 bits (281), Expect = 2e-24
Identities = 75/252 (29%), Positives = 120/252 (47%), Gaps = 5/252 (1%)
Query: 197 LKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 255
L ++ N I+ +P FK P L+ L+L N + + GL LK L +Q N + +
Sbjct: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121
Query: 256 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 315
A GLS ++ L+LD N++T + + GL+ L+ L L N++ + L
Sbjct: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQA 181
Query: 316 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI 375
L L N +S + D +F LS L LH+ NN++ ++ F GL +L+TLDL N +
Sbjct: 182 LTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLG--- 238
Query: 376 EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK 435
+ A L L+ L N I I AF G L + L DN + + +AF +
Sbjct: 239 -EFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSD 297
Query: 436 LQQLHLNTSSLL 447
L L + +S++
Sbjct: 298 LHSLVIRGASMV 309
Score = 90.1 bits (222), Expect = 1e-17
Identities = 76/272 (27%), Positives = 121/272 (44%), Gaps = 17/272 (6%)
Query: 218 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 277
Q L+++ N I + F+ L+ L++ N ++ + A GL +++L L +N L
Sbjct: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKT 119
Query: 278 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL 337
+ + GL LQ L L N I + D++E +L L L N L+ + L L
Sbjct: 120 VPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179
Query: 338 NTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNR 397
L + N++S I D AF LSSL L L NN+I + F GLD L L L N
Sbjct: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQH---CFDGLDNLETLDLNYNN 236
Query: 398 IRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQ 457
+ +A L +L+ L N+I + AF L+ +HL + L
Sbjct: 237 LGEF-PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPL----------S 285
Query: 458 WVAENNFQSFVNASCAHPQLLKGRSIFAVSPD 489
+V + +F N S H +++G S+ P+
Sbjct: 286 FVGNS---AFHNLSDLHSLVIRGASMVQQFPN 314
Score = 86.7 bits (213), Expect = 1e-16
Identities = 85/334 (25%), Positives = 147/334 (44%), Gaps = 47/334 (14%)
Query: 81 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIVEILPE 139
L N L+ + +S+L +L+ + L N++ +IP+ + +++ +L L N+I +
Sbjct: 160 LDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQH 219
Query: 140 HLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLL-VL 197
+LETLDL+ NN+ E A AL LK L +SN ++ + G FD N LL +
Sbjct: 220 CFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDG--NPLLRTI 277
Query: 198 KLNRNRISAIP------------------------PKMFKLPQLQHLELNRNKIKNVDGL 233
L N +S + P + L+ L L KI ++
Sbjct: 278 HLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNN 337
Query: 234 TFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELH 293
Q L++L + N + L +F G +E + L N + +I +G GL+ L+ L
Sbjct: 338 LCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILD 395
Query: 294 LSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL---------------N 338
LS+N I+ I A+ ++ LD++FN L+ GL+ L +
Sbjct: 396 LSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKD 455
Query: 339 TLHIGNNRVSYIAD-CAFRGLSSLKTLDLKNNEI 371
+++ + V Y CAF G S L+ ++N +
Sbjct: 456 FVNLRSLSVPYAYQCCAFWGCDSYANLNTEDNSL 489
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 138 bits (348), Expect = 3e-32
Identities = 105/353 (29%), Positives = 174/353 (49%), Gaps = 33/353 (9%)
Query: 157 ISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLP 215
+S + FP + +LYL N ++ + L ++L+ L L+ + I + PK F +L
Sbjct: 51 LSSIPKNFPESTV-FLYLTGNNISYINESELTGL-HSLVALYLDNSNILYVYPKAFVQLR 108
Query: 216 QLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNL 275
L L LN N IK +D F+GL L++L +Q N V+ + G F L +++ L L N L
Sbjct: 109 HLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRL 168
Query: 276 TEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLS 335
T + G G++ L+ L LS N I RIS ++ + L+ L L N+L+++ ++F L
Sbjct: 169 TVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLK 228
Query: 336 LLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQG 395
L L + +N + I AF+GL++L+ L LKN+ I D FSG++ L+ LIL
Sbjct: 229 SLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRD---GFSGINNLKHLILSH 285
Query: 396 NRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQM---------------------- 433
N + ++ F+ L L +L L N I+S+ + F M
Sbjct: 286 NDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVL 345
Query: 434 ---KKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 483
L L N++ C+C+L L W+A + +N C +P ++GR++
Sbjct: 346 KPLSSLIHLQANSNPWECNCKLLGLRDWLASSAIT--LNIYCQNPPSMRGRAL 396
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 133 bits (335), Expect = 8e-31
Identities = 107/378 (28%), Positives = 171/378 (45%), Gaps = 35/378 (9%)
Query: 244 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 303
L +Q NG+ + F L ++EILQL N + +I G GL L L L N + +
Sbjct: 91 LNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVP 150
Query: 304 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGN-NRVSYIADCAFRGLSSLK 362
A+E+ KL EL L N + + +F + L L +G R+ YI++ AF GL +L+
Sbjct: 151 TQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLR 210
Query: 363 TL--------DLKNNEISWTIEDMN-----------GAFSGLDKLRRLILQGNRIRSITK 403
L D+ N +E++ G+F GL LR+L L ++ +I +
Sbjct: 211 YLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIER 270
Query: 404 KAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN- 462
AF L +LE L+LS N +MSL + F+ + +L+++HLN + C+C + WL W+ E
Sbjct: 271 NAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETV 330
Query: 463 NFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSA 522
+ A C P LKGR I + F C P I P + +G C
Sbjct: 331 PSNTTCCARCHAPAGLKGRYIGELDQSHFTC---YAPVIVEPPTDLNVTEGMAAELKCRT 387
Query: 523 ASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCV 582
+S S N L + + + R + + + T L V G+Y C+
Sbjct: 388 GTSMTSV--------NWLTPNGTLMTHGSYRVRISVLHDGT--LNFTNVTVQDTGQYTCM 437
Query: 583 ISNHFGSSYSVKAKLTVN 600
++N G++ + A L V+
Sbjct: 438 VTNSAGNT-TASATLNVS 454
Score = 86.3 bits (212), Expect = 2e-16
Identities = 79/283 (27%), Positives = 130/283 (45%), Gaps = 18/283 (6%)
Query: 22 GRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDL--LDCSRKRLARLPEPLPSWVARL 79
G A S +GG G P + CP C C + C+R+ LA +P +P L
Sbjct: 40 GVAVTSAAGG----GSPPATS----CPVACSCSNQASRVICTRRDLAEVPASIPVNTRYL 91
Query: 80 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA--NITLLSLAGNRIVEIL 137
+L N + I+ + HL+ L ++L+ N + I +G + ++ L L NR+ +
Sbjct: 92 NLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKI-EVGAFNGLPSLNTLELFDNRLTTVP 150
Query: 138 PEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNS-NRVTSMEPGYFDNLANTL 194
+ + L L L +N I + + AF + L+ L L R+ + F+ L N L
Sbjct: 151 TQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN-L 209
Query: 195 LVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 254
L L + IP + L +L+ LEL+ N++ + +FQGL +L+ L + V +
Sbjct: 210 RYLNLGMCNLKDIP-NLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATI 268
Query: 255 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQN 297
AF L ++E L L HNNL + L L+ +HL+ N
Sbjct: 269 ERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/91 (30%), Positives = 40/91 (43%), Gaps = 1/91 (1%)
Query: 603 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 662
P + P DL + G A L+C G + W GT R + D
Sbjct: 364 PVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422
Query: 663 IVDVKIEDIGVYSCTAQNSAGSISANATLTV 693
+V ++D G Y+C NSAG+ +A+ATL V
Sbjct: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
Score = 37.4 bits (85), Expect = 0.080
Identities = 25/91 (27%), Positives = 40/91 (43%), Gaps = 4/91 (4%)
Query: 697 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERH---FFAAGNQLLI 753
P + P D VT+G A L+C G S +NW + L+ + + L
Sbjct: 364 PVIVEPPTDLNVTEGMAAELKCRTGTSMT-SVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422
Query: 754 IVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 784
+ V D G+YTC ++N+ G + L+V
Sbjct: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 131 bits (330), Expect = 3e-30
Identities = 115/396 (29%), Positives = 185/396 (46%), Gaps = 20/396 (5%)
Query: 128 LAGNRIVEILPE--HLKEFQSLETLDLSSNNISELQTAFPAL---QLKYLYLNSNRVTSM 182
L NR + ++P+ L + T L N I+ + TAF QL+ L L N++ S+
Sbjct: 40 LCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNI-TAFDFHRLGQLRRLDLQYNQIRSL 98
Query: 183 EPGYFDNLANTLLVLKLNRNRISAIPP-KMFKLPQLQHLELNRNKIKNVDGLTFQGLGAL 241
P F+ L+ L L L N + A+ P + L +L+ L N N+I + +F+GL +L
Sbjct: 99 HPKTFEKLSR-LEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESL 157
Query: 242 KSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINR 301
L++ N + L D F L N+ L L+ N + + K L L+ L+LS N +
Sbjct: 158 VKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQP 217
Query: 302 ISPDAWEFC--QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLS 359
A F + LS L L+ N+L L F L L L + N+++++A AF GL
Sbjct: 218 SLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLE 277
Query: 360 SLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSD 419
+L+ L L+ N +S + L L L L GN + ++ F L L L L +
Sbjct: 278 ALRELRLEGNRLS---QLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRN 334
Query: 420 NAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQS---FVNASCAHPQ 476
NA+ +L G+ F+ L +L L+ + CDC+L+ L +W+ + + Q V C HP
Sbjct: 335 NALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPP 394
Query: 477 LLKGRSIFAVS----PDGFVCDDFPKPQITVQPETQ 508
L+G+ + + +G D P +T Q
Sbjct: 395 ALRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQ 430
Score = 104 bits (260), Expect = 4e-22
Identities = 102/345 (29%), Positives = 154/345 (44%), Gaps = 14/345 (4%)
Query: 43 AERPCPTTCRCLGDL-LDCSRKRLARLPE----PLPSWVARLDLSHNRLSFIKASSMSHL 97
AE CP C C L C+ + L +P+ P P V L N ++ I A L
Sbjct: 23 AEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRL 82
Query: 98 QSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNN 156
LR + L N++ ++ P + + L L N + + P L + L L + N
Sbjct: 83 GQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNE 142
Query: 157 ISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-K 213
IS L +F L+ L L L+ N + ++ F L N LL L L NRI + F +
Sbjct: 143 ISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGN-LLYLHLESNRIRFLGKNAFAQ 201
Query: 214 LPQLQHLELNRNKIKNV--DGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLD 271
L +L+ L L+ N+++ TF L +L SL + N + L F L + +L L
Sbjct: 202 LGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLR 261
Query: 272 HNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSF 331
N LT + +GL L+EL L N ++++ E L LDL+ N LS L ++F
Sbjct: 262 GNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATF 321
Query: 332 LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIE 376
L L L + NN +S ++ F +L LDL N WT +
Sbjct: 322 GHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN--GWTCD 364
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 129 bits (324), Expect = 2e-29
Identities = 127/488 (26%), Positives = 207/488 (42%), Gaps = 70/488 (14%)
Query: 43 AERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLS-------------------- 82
A + CP C C G +DC L +P +P RLDL+
Sbjct: 24 APQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRV 83
Query: 83 ----HNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPV-SANITLLSLAGNRIVEIL 137
N++S I+ + L+ L ++LN N L+ P L + +A + L L+ N+I I
Sbjct: 84 LQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIP 143
Query: 138 PEHLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLL 195
+ + ++ L L N IS ++ AF AL+ L+ L LN+N +T + F+++ L
Sbjct: 144 RKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPK-LR 202
Query: 196 VLKLNRNRISA------IPPKMFKLPQL----QHLELNRNKIKNVDGLTFQGLGALKSLK 245
+L+ N + + + + P++ Q + + + NV + +
Sbjct: 203 TFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQS 262
Query: 246 MQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPD 305
+ L A SN I+ LTEI + E+ L QN I I P
Sbjct: 263 FMAPSCSVLHCPAACTCSN-NIVDCRGKGLTEIPTNLPE---TITEIRLEQNTIKVIPPG 318
Query: 306 AWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLD 365
A+ +KL +DL+ NN++S +A AF+GL SL +L
Sbjct: 319 AFSPYKKLRRIDLS------------------------NNQISELAPDAFQGLRSLNSLV 354
Query: 366 LKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSL 425
L N+I+ E F GL L+ L+L N+I + AF L L L L DN + ++
Sbjct: 355 LYGNKIT---ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTI 411
Query: 426 QGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFA 485
FS ++ +Q +HL + +CDC LKWL ++ N ++ A C P+ L + I
Sbjct: 412 AKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIET-SGARCTSPRRLANKRIGQ 470
Query: 486 VSPDGFVC 493
+ F C
Sbjct: 471 IKSKKFRC 478
Score = 115 bits (288), Expect = 2e-25
Identities = 105/393 (26%), Positives = 170/393 (43%), Gaps = 36/393 (9%)
Query: 131 NRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDN 189
N+ + +PEH+ ++ + L+ + + E F L QL+ + ++N++T +E G F+
Sbjct: 521 NQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEG 580
Query: 190 LANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR 248
+ +L L NR+ + KMFK L L+ L L N+I V +F GL +++ L +
Sbjct: 581 ASGVNEIL-LTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYD 639
Query: 249 NGVTKLMDGAFWGLSNMEILQLDHNNLT-EITKGWLYGLL----------------MLQE 291
N +T + GAF L ++ L L N WL L L+E
Sbjct: 640 NQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKE 699
Query: 292 LHLSQNAINRISPDAWE---FCQKLSELDLTFNHLSRLDDSSFLGLSLL--------NTL 340
+ + AI + D C LS L + S GL +L L
Sbjct: 700 IPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTEL 759
Query: 341 HIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRS 400
++ N+ + + L +DL NN IS N +FS + +L LIL NR+R
Sbjct: 760 YLDGNQFTLVPK-ELSNYKHLTLIDLSNNRISTL---SNQSFSNMTQLLTLILSYNRLRC 815
Query: 401 ITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVA 460
I + F GL +L L L N I + AF+ + L L + + L CDC ++WL WV
Sbjct: 816 IPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWV- 874
Query: 461 ENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVC 493
++ ++ A CA P + + + F C
Sbjct: 875 KSEYKEPGIARCAGPGEMADKLLLTTPSKKFTC 907
Score = 58.5 bits (140), Expect = 3e-08
Identities = 44/135 (32%), Positives = 71/135 (52%), Gaps = 6/135 (4%)
Query: 47 CPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLN 106
CPT C CL ++ CS K L LP+ +P V L L N+ + + +S+ + L + L+
Sbjct: 727 CPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLV-PKELSNYKHLTLIDLS 785
Query: 107 NNELETIPN--LGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL-QTA 163
NN + T+ N ++ +TL+ L+ NR+ I P +SL L L N+IS + + A
Sbjct: 786 NNRISTLSNQSFSNMTQLLTLI-LSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGA 844
Query: 164 FPALQ-LKYLYLNSN 177
F L L +L + +N
Sbjct: 845 FNDLSALSHLAIGAN 859
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 126 bits (317), Expect = 1e-28
Identities = 121/428 (28%), Positives = 191/428 (44%), Gaps = 33/428 (7%)
Query: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279
L L+ N+I+ + +F+ L L+ L++ RN + + GAF GL+N+ L+L N LT I
Sbjct: 81 LNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIP 140
Query: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSLLN 338
G L L+EL L N I I A+ L LDL LS + + +F GLS L
Sbjct: 141 NGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLR 200
Query: 339 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 398
L++ + I + L L LDL N +S G+F GL L++L + ++I
Sbjct: 201 YLNLAMCNLREIPN--LTPLIKLDELDLSGNHLS---AIRPGSFQGLMHLQKLWMIQSQI 255
Query: 399 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 458
+ I + AF L +L ++L+ N + L + F+ + L+++HL+ + C+C + WL W
Sbjct: 256 QVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWW 315
Query: 459 VAE-NNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLS 517
+ + + A C P LKGR I + + F C P I P + +G
Sbjct: 316 IKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC---YAPVIVEPPADLNVTEGMAAE 372
Query: 518 FICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEG 577
C A++S S +++ + H A A L L V G
Sbjct: 373 LKCRASTSLTS-VSWITPNGTVMTHGAYKVRIAVLS---------DGTLNFTNVTVQDTG 422
Query: 578 KYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDL--TIRAGAM------ARLECAAVGH 629
Y C++SN G++ A T+N+ + T TP T+ M AR VG
Sbjct: 423 MYTCMVSNSVGNT---TASATLNVTAA-TTTPFSYFSTVTVETMEPSQDEARTTDNNVG- 477
Query: 630 PAPQIAWQ 637
P P + W+
Sbjct: 478 PTPVVDWE 485
Score = 92.0 bits (227), Expect = 3e-18
Identities = 78/269 (28%), Positives = 130/269 (48%), Gaps = 10/269 (3%)
Query: 39 SGVAAERPCPTTCRCLGDL--LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSH 96
+G+ + CP+ C C + C RK L +P+ + + L+L N++ IK +S H
Sbjct: 39 AGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKH 98
Query: 97 LQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSS 154
L+ L ++L+ N + TI +G + AN+ L L NR+ I L+ L L +
Sbjct: 99 LRHLEILQLSRNHIRTI-EIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRN 157
Query: 155 NNISELQT-AFPAL-QLKYLYLNS-NRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKM 211
N I + + AF + L+ L L R++ + G F+ L+N L L L + IP +
Sbjct: 158 NPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSN-LRYLNLAMCNLREIP-NL 215
Query: 212 FKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLD 271
L +L L+L+ N + + +FQGL L+ L M ++ + + AF L ++ + L
Sbjct: 216 TPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLA 275
Query: 272 HNNLTEITKGWLYGLLMLQELHLSQNAIN 300
HNNLT + L L+ +HL N N
Sbjct: 276 HNNLTLLPHDLFTPLHHLERIHLHHNPWN 304
Score = 48.9 bits (115), Expect = 3e-05
Identities = 33/132 (25%), Positives = 54/132 (40%), Gaps = 5/132 (3%)
Query: 603 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 662
P + P DL + G A L+C A ++W GT + + D
Sbjct: 354 PVIVEPPADLNVTEGMAAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLN 412
Query: 663 IVDVKIEDIGVYSCTAQNSAGSISANATLTV---LETP-SFLRPLLDRTVTKGETAVLQC 718
+V ++D G+Y+C NS G+ +A+ATL V TP S+ + T+ +
Sbjct: 413 FTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTT 472
Query: 719 IAGGSPPPKLNW 730
P P ++W
Sbjct: 473 DNNVGPTPVVDW 484
Score = 35.8 bits (81), Expect = 0.23
Identities = 25/96 (26%), Positives = 41/96 (42%), Gaps = 4/96 (4%)
Query: 697 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERH---FFAAGNQLLI 753
P + P D VT+G A L+C A S ++W + ++ + + L
Sbjct: 354 PVIVEPPADLNVTEGMAAELKCRASTSLT-SVSWITPNGTVMTHGAYKVRIAVLSDGTLN 412
Query: 754 IVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 789
+ V D G YTC +SN++G + L+V T
Sbjct: 413 FTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATT 448
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 124 bits (312), Expect = 4e-28
Identities = 81/252 (32%), Positives = 118/252 (46%), Gaps = 23/252 (9%)
Query: 531 TFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSS 590
T +WKKD L D + + +GG++M + + GKY CV +N G
Sbjct: 162 TISWKKDGSPLDDKD----ERITIRGGKLM-------ITYTRKSDAGKYVCVGTNMVGER 210
Query: 591 YSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARER 650
S A+LTV PSF K P +L + A +C A G P P + W+KD G + P +R
Sbjct: 211 ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR-- 267
Query: 651 RMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTK 710
+ + +D I V D+G Y+C A+N G A+ATLTV E P F+ D+ V
Sbjct: 268 --YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL 325
Query: 711 GETAVLQCIAGGSPPPKLNWTKDDSPLVV-------TERHFFAAGNQLLIIVDSDVSDAG 763
G T QC A G+P P + W ++ S ++ + F + L I + SD G
Sbjct: 326 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 385
Query: 764 KYTCEMSNTLGT 775
Y C+ N G+
Sbjct: 386 YYICQTLNVAGS 397
Score = 111 bits (278), Expect = 3e-24
Identities = 86/298 (28%), Positives = 124/298 (41%), Gaps = 13/298 (4%)
Query: 494 DDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLR 553
+DFP P+I P KG + C A T W K E + + + +H
Sbjct: 25 EDFP-PRIVEHPSDLIVSKGEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRM 81
Query: 554 AQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML-PSFTKTPMDL 612
+ + I+ R+ EG Y CV N+ G + S A L V +L F + P D+
Sbjct: 82 LLPSGSLFFLRIVHGRKSR-PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 140
Query: 613 TIRAGAMARLECAAV-GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 671
+ G A +EC GHP P I+W+KDG ++ + I + D
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDA 196
Query: 672 GVYSCTAQNSAGSISAN-ATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNW 730
G Y C N G + A LTVLE PSF++ + VT ++A +C A G P P + W
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 731 TKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788
KDD L + + + L I D G YTC N +G + L+V P
Sbjct: 257 RKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312
Score = 109 bits (272), Expect = 2e-23
Identities = 90/321 (28%), Positives = 131/321 (40%), Gaps = 35/321 (10%)
Query: 498 KPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGG 557
+P +P + + F C A D T W+KD D E+ +
Sbjct: 222 RPSFVKRPSNLAVTVDDSAEFKCEARG--DPVPTVRWRKD-----DGELPKSRY------ 268
Query: 558 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAG 617
E+ + T L++R+V G Y CV N G + A LTV P F P D + G
Sbjct: 269 EIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKA-EASATLTVQEPPHFVVKPRDQVVALG 326
Query: 618 AMARLECAAVGHPAPQIAWQKDGGTDF-----PAARERRMHVMPEDDVFFIVDVKIEDIG 672
+C A G+P P I W+++G + P R V D+ I +V+ D+G
Sbjct: 327 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVG 385
Query: 673 VYSCTAQNSAGSISANATLTVLET------PSFLRPLLDRTVTKGETAVLQCIAGGSPPP 726
Y C N AGSI A L V + P + +++TV T VL C+A GSP P
Sbjct: 386 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 445
Query: 727 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV-- 784
+ W KD + + N +L I + + D G+YTC S G + + V
Sbjct: 446 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 505
Query: 785 ------IPTPTCDSPQMTAPS 799
P PT + +APS
Sbjct: 506 FGVPVQPPRPTDPNLIPSAPS 526
Score = 96.3 bits (238), Expect = 1e-19
Identities = 75/212 (35%), Positives = 102/212 (48%), Gaps = 14/212 (6%)
Query: 603 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDG---GTDFPAARERRMHVMPEDD 659
P + P DL + G A L C A G P P I W K G TD R RM ++P
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 87
Query: 660 VFFIVDV----KIEDIGVYSCTAQNSAG-SISANATLTV-LETPSFLRPLLDRTVTKGET 713
+FF+ V D GVY C A+N G ++S NA+L V + F + D V GE
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
Query: 714 AVLQC-IAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 772
AV++C G P P ++W KD SPL + G +L+I + SDAGKY C +N
Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITY-TRKSDAGKYVCVGTNM 206
Query: 773 LGTERGNV-RLSVIPTPT-CDSPQMTAPSLDD 802
+G V L+V+ P+ P A ++DD
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDD 238
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 124 bits (312), Expect = 4e-28
Identities = 81/252 (32%), Positives = 118/252 (46%), Gaps = 23/252 (9%)
Query: 531 TFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSS 590
T +WKKD L D + + +GG++M + + GKY CV +N G
Sbjct: 201 TISWKKDGSPLDDKD----ERITIRGGKLM-------ITYTRKSDAGKYVCVGTNMVGER 249
Query: 591 YSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARER 650
S A+LTV PSF K P +L + A +C A G P P + W+KD G + P +R
Sbjct: 250 ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR-- 306
Query: 651 RMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTK 710
+ + +D I V D+G Y+C A+N G A+ATLTV E P F+ D+ V
Sbjct: 307 --YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL 364
Query: 711 GETAVLQCIAGGSPPPKLNWTKDDSPLVV-------TERHFFAAGNQLLIIVDSDVSDAG 763
G T QC A G+P P + W ++ S ++ + F + L I + SD G
Sbjct: 365 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 424
Query: 764 KYTCEMSNTLGT 775
Y C+ N G+
Sbjct: 425 YYICQTLNVAGS 436
Score = 111 bits (278), Expect = 3e-24
Identities = 86/298 (28%), Positives = 124/298 (41%), Gaps = 13/298 (4%)
Query: 494 DDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLR 553
+DFP P+I P KG + C A T W K E + + + +H
Sbjct: 64 EDFP-PRIVEHPSDLIVSKGEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRM 120
Query: 554 AQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML-PSFTKTPMDL 612
+ + I+ R+ EG Y CV N+ G + S A L V +L F + P D+
Sbjct: 121 LLPSGSLFFLRIVHGRKSR-PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 179
Query: 613 TIRAGAMARLECAAV-GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 671
+ G A +EC GHP P I+W+KDG ++ + I + D
Sbjct: 180 MVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDA 235
Query: 672 GVYSCTAQNSAGSISAN-ATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNW 730
G Y C N G + A LTVLE PSF++ + VT ++A +C A G P P + W
Sbjct: 236 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 295
Query: 731 TKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788
KDD L + + + L I D G YTC N +G + L+V P
Sbjct: 296 RKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 351
Score = 109 bits (272), Expect = 2e-23
Identities = 90/321 (28%), Positives = 131/321 (40%), Gaps = 35/321 (10%)
Query: 498 KPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGG 557
+P +P + + F C A D T W+KD D E+ +
Sbjct: 261 RPSFVKRPSNLAVTVDDSAEFKCEARG--DPVPTVRWRKD-----DGELPKSRY------ 307
Query: 558 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAG 617
E+ + T L++R+V G Y CV N G + A LTV P F P D + G
Sbjct: 308 EIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKA-EASATLTVQEPPHFVVKPRDQVVALG 365
Query: 618 AMARLECAAVGHPAPQIAWQKDGGTDF-----PAARERRMHVMPEDDVFFIVDVKIEDIG 672
+C A G+P P I W+++G + P R V D+ I +V+ D+G
Sbjct: 366 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVG 424
Query: 673 VYSCTAQNSAGSISANATLTVLET------PSFLRPLLDRTVTKGETAVLQCIAGGSPPP 726
Y C N AGSI A L V + P + +++TV T VL C+A GSP P
Sbjct: 425 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 484
Query: 727 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV-- 784
+ W KD + + N +L I + + D G+YTC S G + + V
Sbjct: 485 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 544
Query: 785 ------IPTPTCDSPQMTAPS 799
P PT + +APS
Sbjct: 545 FGVPVQPPRPTDPNLIPSAPS 565
Score = 96.3 bits (238), Expect = 1e-19
Identities = 75/212 (35%), Positives = 102/212 (48%), Gaps = 14/212 (6%)
Query: 603 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDG---GTDFPAARERRMHVMPEDD 659
P + P DL + G A L C A G P P I W K G TD R RM ++P
Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 126
Query: 660 VFFIVDV----KIEDIGVYSCTAQNSAG-SISANATLTV-LETPSFLRPLLDRTVTKGET 713
+FF+ V D GVY C A+N G ++S NA+L V + F + D V GE
Sbjct: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186
Query: 714 AVLQC-IAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 772
AV++C G P P ++W KD SPL + G +L+I + SDAGKY C +N
Sbjct: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITY-TRKSDAGKYVCVGTNM 245
Query: 773 LGTERGNV-RLSVIPTPT-CDSPQMTAPSLDD 802
+G V L+V+ P+ P A ++DD
Sbjct: 246 VGERESEVAELTVLERPSFVKRPSNLAVTVDD 277
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 123 bits (309), Expect = 9e-28
Identities = 87/292 (29%), Positives = 130/292 (44%), Gaps = 17/292 (5%)
Query: 497 PKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQG 556
P P I V P + G C S+ D +T W++++ D + A +R
Sbjct: 519 PPPVIQV-PNNVTVTPGERAVLTCLIISAVDYNLT--WQRNDR---DVRLAEPARIRTLA 572
Query: 557 GEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRA 616
+E L+ V+F G+Y C++S+ GSS + LTV P T P + +
Sbjct: 573 NLSLE------LKSVKFNDAGEYHCMVSSEGGSS-AASVFLTVQEPPKVTVMPKNQSFTG 625
Query: 617 GAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 676
G+ + C+A G+P P+IAW + + R R M D FI + +D G+Y C
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYR----MTSDGTLFIKNAAPKDAGIYGC 681
Query: 677 TAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSP 736
A NSAG+ N+TL +E P + + V G+ V++C G PPP++ W K D
Sbjct: 682 LASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLE 741
Query: 737 LVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788
L + LL I ++ DAG YTC N G G + L V P
Sbjct: 742 LRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPP 793
Score = 120 bits (301), Expect = 7e-27
Identities = 82/288 (28%), Positives = 128/288 (44%), Gaps = 19/288 (6%)
Query: 506 ETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTI 565
E + I + +S C +++ P T W KD L ++ L GG V
Sbjct: 2785 EAKDVIINNPISLYCE--TNAAPPPTLTWYKDGHPLTSSDKV----LILPGGRV------ 2832
Query: 566 LRLREVEFASEGKYQCVISNHFGSS---YSVKAKLTVNMLPSFTKTPMDLTIRAGAMARL 622
L++ + G+Y CV N G Y V+ + + + + P ++T+ A +
Sbjct: 2833 LQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALI 2892
Query: 623 ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 682
EC + G PAP+ +WQKDG P + + + I++ +I DIG Y C A+N+A
Sbjct: 2893 ECLSSGSPAPRNSWQKDGQ---PLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTA 2949
Query: 683 GSISANATLTVLETPSFLRPLLDR-TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTE 741
GS L V PS + P + TV L C G PPP L+W K++ P+ +
Sbjct: 2950 GSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNT 3009
Query: 742 RHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 789
G + L I+ + VSD G+YTC N G + L+V P+
Sbjct: 3010 NTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057
Score = 120 bits (300), Expect = 9e-27
Identities = 80/283 (28%), Positives = 132/283 (46%), Gaps = 21/283 (7%)
Query: 512 KGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREV 571
+G ++S C P T W KD L ++A+G E+++ IL+L+ +
Sbjct: 2306 RGKSISLECEVQGIP--PPTVTWMKDGHPL----------IKAKGVEILDEGHILQLKNI 2353
Query: 572 EFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT---KTPMDLTIRAGAMARLECAAVG 628
+ G+Y CV N G + K L+V+ PS ++P ++++ L C A G
Sbjct: 2354 HVSDTGRYVCVAVNVAGMT-DKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASG 2412
Query: 629 HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 688
P P I W KDG +P + + ++ + ++ +ED G Y+C +N+AG
Sbjct: 2413 IPLPSITWFKDG---WPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKI 2469
Query: 689 ATLTVLETPSFL--RPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFA 746
L+VL P + L D V + ++ L C G+P P++ W KD PL E H
Sbjct: 2470 FGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHII 2529
Query: 747 AGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 789
+G + L I + V G+YTC S+ G + + L+V +PT
Sbjct: 2530 SGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPT 2572
Score = 113 bits (282), Expect = 1e-24
Identities = 87/331 (26%), Positives = 145/331 (43%), Gaps = 24/331 (7%)
Query: 505 PETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTT 564
PE + ++ + + ++ P T AW K+++ +EN L + ++ +
Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHK-----RIENSDSLEVR---ILSGGS 3207
Query: 565 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT--KTPMDLTIRAGAMARL 622
L++ + + G Y C+ SN G + L++ + PS + P D+++ G L
Sbjct: 3208 KLQIARSQHSDSGNYTCIASNMEGKAQKYYF-LSIQVPPSVAGAEIPSDVSVLLGENVEL 3266
Query: 623 ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 682
C A G P P I W KDG + R+ V I D G Y+C A N A
Sbjct: 3267 VCNANGIPTPLIQWLKDG-KPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPA 3325
Query: 683 GSISANATLTVLETPSFL--RPLLDRTVTKGETAV-LQCIAGGSPPPKLNWTKDDSPLVV 739
G L V TP+ + ++ +T +T++ ++C A G+PPP++NW K+ PL +
Sbjct: 3326 GEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPL 3385
Query: 740 TERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPS 799
+ A Q++ IV + VSD YTC SN G + + L V P D+ T
Sbjct: 3386 SSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEI 3445
Query: 800 LDDDGWATVGVVIIAVVCCVVGT---SLVWV 827
G +T ++ C GT S+ W+
Sbjct: 3446 TVLKGSST------SMACITDGTPAPSMAWL 3470
Score = 112 bits (281), Expect = 2e-24
Identities = 78/280 (27%), Positives = 130/280 (46%), Gaps = 30/280 (10%)
Query: 531 TFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSS 590
+ +W KD + L + +++ ++ A G L+++E + + G+Y CV SN G
Sbjct: 2705 SLSWYKDGQPL---KSDDHVNIAANGHT-------LQIKEAQISDTGRYTCVASNIAGED 2754
Query: 591 YSVKAKLTVNMLPSFTKT----PMDLTIRAGAMA--------RLECAAVGHPAPQIAWQK 638
+ + + + PSF K M T R G L C P P + W K
Sbjct: 2755 -ELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYK 2813
Query: 639 DGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPS 698
DG P ++ ++P V I K+ED G Y+C A N AG S + VL P
Sbjct: 2814 DG---HPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPI 2870
Query: 699 FLRPLLDR----TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLII 754
D TV ++A+++C++ GSP P+ +W KD PL+ + H F + ++L I
Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQI 2930
Query: 755 VDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQ 794
+++ ++D G+Y C NT G+ + L+V P+ P+
Sbjct: 2931 LNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK 2970
Score = 111 bits (277), Expect = 4e-24
Identities = 77/278 (27%), Positives = 125/278 (44%), Gaps = 16/278 (5%)
Query: 520 CSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKY 579
C AA + +T W KDN LL + + + R Q I+ + + + G Y
Sbjct: 1942 CKAAGNPVPVIT--WYKDNRLLSGSTSMTFLN-RGQ---------IIDIESAQISDAGIY 1989
Query: 580 QCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKD 639
+CV N G++ + L V++ PS + + + + RLEC A G PAP + W KD
Sbjct: 1990 KCVAINSAGAT-ELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKD 2048
Query: 640 GGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSF 699
G ++ + V+ + + +I D G Y+C A N+AG + L V P+
Sbjct: 2049 GSP--VSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNI 2106
Query: 700 LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDV 759
+ + +V + L C + PPP L W KD PL+ + +L I D+ V
Sbjct: 2107 MGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQV 2166
Query: 760 SDAGKYTCEMSNTLGTERGNVRLSV-IPTPTCDSPQMT 796
D G+YTCE +N G N +++ +P S ++T
Sbjct: 2167 QDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELT 2204
Score = 109 bits (273), Expect = 1e-23
Identities = 78/289 (26%), Positives = 125/289 (43%), Gaps = 19/289 (6%)
Query: 505 PETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTT 564
P S + G N+ +C+A + +P+ W KD + + E E + A G + Y
Sbjct: 3253 PSDVSVLLGENVELVCNA-NGIPTPL-IQWLKDGKPIASGETERI-RVSANGSTLNIYGA 3309
Query: 565 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD---LTIRAGAMAR 621
+ + GKY CV +N G + L V + P+ + L
Sbjct: 3310 LT-------SDTGKYTCVATNPAGEEDRI-FNLNVYVTPTIRGNKDEAEKLMTLVDTSIN 3361
Query: 622 LECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNS 681
+EC A G P PQI W K+G P + ++ V IV ++ D+ VY+C A N
Sbjct: 3362 IECRATGTPPPQINWLKNG---LPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNR 3418
Query: 682 AGSISANATLTVLETPSFLRPL--LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVV 739
AG + + L V P+ + + TV KG + + CI G+P P + W +D PL +
Sbjct: 3419 AGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGL 3478
Query: 740 TERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788
+ +L ++ ++ D+GKYTC SN G + L V+ P
Sbjct: 3479 DAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPP 3527
Score = 103 bits (258), Expect = 7e-22
Identities = 85/291 (29%), Positives = 122/291 (41%), Gaps = 17/291 (5%)
Query: 499 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 558
P I QP I + + C A + +T W+K+ ++ + N+A L + G
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFIT--WQKEGINVNTSG-RNHAVLPSGG-- 4042
Query: 559 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 618
L++ G Y CV N G++ K KL V + P + + I
Sbjct: 4043 -------LQISRAVREDAGTYMCVAQNPAGTALG-KIKLNVQVPPVISPHLKEYVIAVDK 4094
Query: 619 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 678
L C A G P P I W KDG + R+R + I V+ D G Y+C A
Sbjct: 4095 PITLSCEADGLPPPDITWHKDGRAIVESIRQRVL----SSGSLQIAFVQPGDAGHYTCMA 4150
Query: 679 QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLV 738
N AGS S + LTV P TV + A+L C+A G P P +NW KD+ L
Sbjct: 4151 ANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLA 4210
Query: 739 VTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 789
+ A LI+ + + D+G YTC +N G + V L+V PT
Sbjct: 4211 NLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPT 4261
Score = 103 bits (256), Expect = 1e-21
Identities = 73/281 (25%), Positives = 117/281 (41%), Gaps = 12/281 (4%)
Query: 508 QSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILR 567
QS + N S + + W+KD +L N+A ++E L
Sbjct: 3720 QSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAG----NHARY-----SILE-NGFLH 3769
Query: 568 LREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAV 627
++ G+Y C+ +N G+ + L V++ PS P ++T+ L C A
Sbjct: 3770 IQSAHVTDTGRYLCMATNAAGTDRR-RIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEAT 3828
Query: 628 GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISA 687
G P P I W+K+G + + + + I+ ++D Y CT N AG
Sbjct: 3829 GIPKPSINWRKNGHL-LNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKR 3887
Query: 688 NATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAA 747
LTV PS D VTK AV+ C A G P P ++WTK+ L+ +
Sbjct: 3888 TVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRIL 3947
Query: 748 GNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788
+ + I+ + ++ AG+YTC N G+ +V L V P
Sbjct: 3948 SSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPP 3988
Score = 102 bits (254), Expect = 2e-21
Identities = 78/287 (27%), Positives = 118/287 (41%), Gaps = 20/287 (6%)
Query: 506 ETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTI 565
E S I + L C A+ MT W KD L + GGEV
Sbjct: 3536 EEISVIVNNPLELTCIASGIPAPKMT--WMKDGRPLPQTDQVQ----TLGGGEV------ 3583
Query: 566 LRLREVEFASEGKYQCVISNHFGSS---YSVKAKLTVNMLPSFTKTPMDLTIRAGAMARL 622
LR+ + G+Y C+ S+ G Y V+ + N+ + T P D+T+ L
Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNI--AGTDEPRDITVLRNRQVTL 3641
Query: 623 ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 682
EC + P P I W ++G R+ ++ I + + D Y+C A N A
Sbjct: 3642 ECKSDAVPPPVITWLRNGER---LQATPRVRILSGGRYLQINNADLGDTANYTCVASNIA 3698
Query: 683 GSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTER 742
G + LTV P+ + ++ VL+CIA G P P++ W KD + L
Sbjct: 3699 GKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHA 3758
Query: 743 HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 789
+ N L I + V+D G+Y C +N GT+R + L V P+
Sbjct: 3759 RYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPS 3805
Score = 102 bits (254), Expect = 2e-21
Identities = 78/256 (30%), Positives = 107/256 (41%), Gaps = 18/256 (7%)
Query: 534 WKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSV 593
WKKDN LL + G E L L V G Y CV +N G
Sbjct: 4202 WKKDNVLLANL----------LGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHT 4251
Query: 594 KAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMH 653
LTV++LP+FT+ P D+++ G RL C A G P P++ W + PA
Sbjct: 4252 -VSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNI-IPA----HFD 4305
Query: 654 VMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTK-GE 712
+ I V ED G Y CTA+NS G + A + V E P F + G
Sbjct: 4306 SVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGG 4365
Query: 713 TAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 772
A+L C G P P + W + + ++ R GN L I + DAG YTC +N
Sbjct: 4366 NAILNCEVKGDPTPTIQWNRKGVDIEISHR-IRQLGNGSLAIYGTVNEDAGDYTCVATNE 4424
Query: 773 LGTERGNVRLSVIPTP 788
G ++ L++ P
Sbjct: 4425 AGVVERSMSLTLQSPP 4440
Score = 102 bits (253), Expect = 3e-21
Identities = 77/285 (27%), Positives = 119/285 (41%), Gaps = 19/285 (6%)
Query: 515 NLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFA 574
N S + SS +W+KD + L +E+ H G IL++ +
Sbjct: 2887 NKSALIECLSSGSPAPRNSWQKDGQPL----LEDDHHKFLSNGR------ILQILNTQIT 2936
Query: 575 SEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD-LTIRAGAMARLECAAVGHPAPQ 633
G+Y CV N GS+ L V++ PS + LT+ L C G P P
Sbjct: 2937 DIGRYVCVAENTAGSAKKY-FNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPD 2995
Query: 634 IAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTV 693
++W K+ + P ++P I+ K+ D G Y+C A N AG +LTV
Sbjct: 2996 LSWLKN---EQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV 3052
Query: 694 LETPSFL----RPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGN 749
PS L V +G + L+C + PPP + W K+ + + A
Sbjct: 3053 YVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG 3112
Query: 750 QLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQ 794
Q+L I ++VSD G+Y C N G + N L+V P+ + P+
Sbjct: 3113 QMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPE 3157
Score = 101 bits (252), Expect = 3e-21
Identities = 69/210 (32%), Positives = 101/210 (48%), Gaps = 8/210 (3%)
Query: 566 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 625
L++ V+ G Y C+ +N GSS S KLTV++ P T T+ + A L C
Sbjct: 4133 LQIAFVQPGDAGHYTCMAANVAGSS-STSTKLTVHVPPRIRSTEGHYTVNENSQAILPCV 4191
Query: 626 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 685
A G P P I W+KD + A + + +V +ED G Y+C A N+AG
Sbjct: 4192 ADGIPTPAINWKKD---NVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGED 4248
Query: 686 SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 745
+ +LTV P+F D ++ KGE L C A G P PKL WT +++ + HF
Sbjct: 4249 THTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNN---IIPAHFD 4305
Query: 746 AA-GNQLLIIVDSDVSDAGKYTCEMSNTLG 774
+ G+ L+I D+G Y C N++G
Sbjct: 4306 SVNGHSELVIERVSKEDSGTYVCTAENSVG 4335
Score = 98.2 bits (243), Expect = 4e-20
Identities = 63/245 (25%), Positives = 107/245 (43%), Gaps = 9/245 (3%)
Query: 558 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT--KTPMDLTIR 615
E+++ +L L+ +G+YQC +SN G + KLT+ + PS D+++
Sbjct: 1502 ELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQ-AKDIKLTIYIPPSIKGGNVTTDISVL 1560
Query: 616 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 675
++ +LEC G P P I W KDG P + + + I ++ D Y+
Sbjct: 1561 INSLIKLECETRGLPMPAITWYKDGQ---PIMSSSQALYIDKGQYLHIPRAQVSDSATYT 1617
Query: 676 CTAQNSAGSISANATLTVLETPSF---LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTK 732
C N AG+ + + V P L L++ V + L+C A G+P P L W K
Sbjct: 1618 CHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLK 1677
Query: 733 DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 792
D P+ + AG + L I+ + D G+Y C ++ G + + V+ P +
Sbjct: 1678 DGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEG 1737
Query: 793 PQMTA 797
T+
Sbjct: 1738 GDETS 1742
Score = 97.4 bits (241), Expect = 7e-20
Identities = 77/297 (25%), Positives = 122/297 (41%), Gaps = 21/297 (7%)
Query: 499 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 558
P I + + S + + +C S + P T W KD L L+ G
Sbjct: 2104 PNIMGEEQNVSVLISQAVELLCQ--SDAIPPPTLTWLKDGHPL----------LKKPGLS 2151
Query: 559 VMEYTTILRLREVEFASEGKYQCVISNHFGSS---YSVKAKLTVNMLPSFTKTPMDLTIR 615
+ E ++L++ + + G+Y C +N G + Y+V + N+ S T LT+
Sbjct: 2152 ISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELT--QLTVI 2209
Query: 616 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 675
G + L C + G P P + W+K G + R + ++ I + D +YS
Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGR-VRILSGGRQLQISIAEKSDAALYS 2268
Query: 676 CTAQNSAGSISANATLTVLETPSFLRPLLDRT---VTKGETAVLQCIAGGSPPPKLNWTK 732
C A N AG+ L V P+ T VT+G++ L+C G PPP + W K
Sbjct: 2269 CVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMK 2328
Query: 733 DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 789
D PL+ + +L + + VSD G+Y C N G LSV P+
Sbjct: 2329 DGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPS 2385
Score = 96.7 bits (239), Expect = 1e-19
Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 23/303 (7%)
Query: 505 PETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTT 564
PE S ++ +++S C A+ +T W KD + N + + G
Sbjct: 2393 PENISVVEKNSVSLTCEASGIPLPSIT--WFKDG---WPVSLSNSVRILSGG-------R 2440
Query: 565 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT--KTPMDLTIRAGAMARL 622
+LRL + G+Y CV+ N G + L+V + P T D+ ++ L
Sbjct: 2441 MLRLMQTTMEDAGQYTCVVRNAAGEERKIFG-LSVLVPPHIVGENTLEDVKVKEKQSVTL 2499
Query: 623 ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 682
C G+P P+I W KDG P + H++ I +V++ G Y+C A + A
Sbjct: 2500 TCEVTGNPVPEITWHKDGQ---PLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPA 2556
Query: 683 GSISANATLTVLETPSFLRPLLDR-----TVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 737
G S + +L V +P+ D TV L C A PP + W KD +PL
Sbjct: 2557 GHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPL 2616
Query: 738 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTA 797
G + L I+++ +AG+Y+C +N G + + V P + +
Sbjct: 2617 ESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWG 2676
Query: 798 PSL 800
P L
Sbjct: 2677 PGL 2679
Score = 96.7 bits (239), Expect = 1e-19
Identities = 78/297 (26%), Positives = 119/297 (40%), Gaps = 15/297 (5%)
Query: 499 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 558
P I P + I + C A + W+K+ LL+ + +N L + G
Sbjct: 3804 PSIAPGPTNMTVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSL 3861
Query: 559 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 618
V+ ++ Y+C ++N G LTV + PS P D + A
Sbjct: 3862 VIISPSV--------DDTATYECTVTNGAGDDKRT-VDLTVQVPPSIADEPTDFLVTKHA 3912
Query: 619 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 678
A + C A G P P I W K+G P R+ I+ ++ G Y+C A
Sbjct: 3913 PAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRIL---SSGAIEILATQLNHAGRYTCVA 3969
Query: 679 QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLV 738
+N+AGS + TL V E P + V +L C A G+P P + W K+ +
Sbjct: 3970 RNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVN 4029
Query: 739 VTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM 795
+ R+ + L I + DAG Y C N GT G ++L+V P SP +
Sbjct: 4030 TSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNV-QVPPVISPHL 4085
Score = 95.5 bits (236), Expect = 2e-19
Identities = 78/318 (24%), Positives = 138/318 (43%), Gaps = 25/318 (7%)
Query: 482 SIFAVSPDGFVCDDFPKPQIT---VQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDN 538
++ + F D + P I P + + +L+ C AA + +T W KD
Sbjct: 1622 NVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILT--WLKDG 1679
Query: 539 ELLHDAEMENYAHLRAQ-GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKL 597
++ ++R + GG+ +E I+ +E++ G+Y CV ++ G +K ++
Sbjct: 1680 -----VPVKANDNIRIEAGGKKLE---IMSAQEID---RGQYICVATSVAGEK-EIKYEV 1727
Query: 598 TVNMLPSFT--KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVM 655
V + P+ + + L+C G P P I W KDG ++
Sbjct: 1728 DVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQL---IDERDGFKIL 1784
Query: 656 PEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRP-LLDRTVTKGETA 714
I ++ + G+Y C A N+AG +TV P+ L +R V K +
Sbjct: 1785 LNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPV 1844
Query: 715 VLQCIAGGSPPPKLNWTKDDSPLVVTERHF-FAAGNQLLIIVDSDVSDAGKYTCEMSNTL 773
LQCIA G P P + W KDD P+ + + + ++L I + + DAG+YTC +N
Sbjct: 1845 ALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAA 1904
Query: 774 GTERGNVRLSVIPTPTCD 791
G + +++L V P+ +
Sbjct: 1905 GETQQHIQLHVHEPPSLE 1922
Score = 95.5 bits (236), Expect = 2e-19
Identities = 72/266 (27%), Positives = 121/266 (45%), Gaps = 20/266 (7%)
Query: 529 PMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFG 588
P T W KD +L+ + + G +++ L + + + ++ G Y+C+ +N G
Sbjct: 1763 PPTIMWLKDGQLIDERD----------GFKILLNGRKLVIAQAQVSNTGLYRCMAANTAG 1812
Query: 589 SSYSVKAKLTVNMLPSFTKTPMD--LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPA 646
+ + ++TV++ P+ + + + ++ +A L+C A G P P I W KD D P
Sbjct: 1813 D-HKKEFEVTVHVPPTIKSSGLSERVVVKYKPVA-LQCIANGIPNPSITWLKD---DQPV 1867
Query: 647 -ARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSF--LRPL 703
+ + + V I +ED G Y+C A N+AG + L V E PS +
Sbjct: 1868 NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKM 1927
Query: 704 LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAG 763
L+ TV L+C A G+P P + W KD+ L + F Q++ I + +SDAG
Sbjct: 1928 LNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAG 1987
Query: 764 KYTCEMSNTLGTERGNVRLSVIPTPT 789
Y C N+ G L V P+
Sbjct: 1988 IYKCVAINSAGATELFYSLQVHVAPS 2013
Score = 94.0 bits (232), Expect = 7e-19
Identities = 79/307 (25%), Positives = 122/307 (39%), Gaps = 36/307 (11%)
Query: 499 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLH------DAEMENYAHL 552
P I + S I+G ++ C A S + + W K EL+ A + ++
Sbjct: 981 PTIQHGQQILSTIEGIPVTLPCKA--SGNPKPSVIWSKKGELISTSSAKFSAGADGSLYV 1038
Query: 553 RAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF------- 605
+ GGE G+Y C +N G + K +LTV + P
Sbjct: 1039 VSPGGE----------------ESGEYVCTATNTAGYAKR-KVQLTVYVRPRVFGDQRGL 1081
Query: 606 -TKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIV 664
P+++++ AG L C P P I W K+ P + H I
Sbjct: 1082 SQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPR---HTFLPSGSMKIT 1138
Query: 665 DVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSP 724
+ + D G+Y C A N AG+++ L V P R V G+ + C A G+P
Sbjct: 1139 ETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTP 1198
Query: 725 PPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 784
P + W+K S ++V H + + L I + SDAG YTC +N GT+ + L V
Sbjct: 1199 LPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHV 1258
Query: 785 IPTPTCD 791
PT +
Sbjct: 1259 QEPPTVE 1265
Score = 93.6 bits (231), Expect = 9e-19
Identities = 72/269 (26%), Positives = 113/269 (42%), Gaps = 27/269 (10%)
Query: 534 WKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSV 593
W KD + L + E AH GG ++ T V+ G+Y C+ S+ G S
Sbjct: 2513 WHKDGQPLQEDE----AHHIISGGRFLQITN------VQVPHTGRYTCLASSPAGHK-SR 2561
Query: 594 KAKLTVNMLPSFTKT-----PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAAR 648
L V + P+ P D+T+ + L C A +P I W KDG P
Sbjct: 2562 SFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGT---PLES 2618
Query: 649 ERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLL---- 704
R + ++P I++ + ++ G YSC A N AG + + + V P + L
Sbjct: 2619 NRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPG 2678
Query: 705 ----DRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS 760
+ + T L+C A P L+W KD PL + AA L I ++ +S
Sbjct: 2679 LSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQIS 2738
Query: 761 DAGKYTCEMSNTLGTERGNVRLSVIPTPT 789
D G+YTC SN G + + +++ P+
Sbjct: 2739 DTGRYTCVASNIAGEDELDFDVNIQVPPS 2767
Score = 93.2 bits (230), Expect = 1e-18
Identities = 67/218 (30%), Positives = 93/218 (42%), Gaps = 5/218 (2%)
Query: 577 GKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 636
G+Y CV N GS++ L V+ P P +L + L C A G P+P I W
Sbjct: 3963 GRYTCVARNAAGSAHR-HVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITW 4021
Query: 637 QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLET 696
QK+G + R V+P + V+ ED G Y C AQN AG+ L V
Sbjct: 4022 QKEGINVNTSGRNHA--VLPSGGLQISRAVR-EDAGTYMCVAQNPAGTALGKIKLNVQVP 4078
Query: 697 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVD 756
P L + + + L C A G PPP + W KD +V + R + L I
Sbjct: 4079 PVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAF- 4137
Query: 757 SDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQ 794
DAG YTC +N G+ + +L+V P S +
Sbjct: 4138 VQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTE 4175
Score = 89.7 bits (221), Expect = 1e-17
Identities = 63/228 (27%), Positives = 98/228 (42%), Gaps = 7/228 (3%)
Query: 565 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLTIRAGAMARL 622
IL+L G+Y C N G+S + V + P+ T P ++++ L
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQKY-FNIDVLVPPTIIGTNFPNEVSVVLNRDVAL 1473
Query: 623 ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 682
EC G P P I W KDG F + + ++ V + + + D G Y CT N+A
Sbjct: 1474 ECQVKGTPFPDIHWFKDGKPLFLG--DPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAA 1531
Query: 683 GSISANATLTVLETPSFL--RPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVT 740
G + + LT+ PS D +V L+C G P P + W KD P++ +
Sbjct: 1532 GKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSS 1591
Query: 741 ERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788
+ + Q L I + VSD+ YTC ++N GT + + V P
Sbjct: 1592 SQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPP 1639
Score = 89.4 bits (220), Expect = 2e-17
Identities = 65/244 (26%), Positives = 104/244 (42%), Gaps = 12/244 (4%)
Query: 565 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLEC 624
+L+++E + G Y CV N G + K L V P F + P D+++ G+ L C
Sbjct: 756 LLKIQETQDLDAGDYTCVAINEAGRATG-KITLDVGSPPVFIQEPADVSMEIGSNVTLPC 814
Query: 625 AAVGHPAPQIAWQK-DGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAG 683
G+P P I W++ D F FI+++ D G Y C A+N G
Sbjct: 815 YVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFG 874
Query: 684 SISANATLTVLETPSFLRPLLD-----RTVTKGETAVLQC-IAGGSPPPKLNWTKDDSPL 737
I + T+TV + PL+ V +G+ L C + G+P P+ W K+ S +
Sbjct: 875 KIQSETTVTVT---GLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKN-SAM 930
Query: 738 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTA 797
++ + + L I + D G+YTC SN GT + V PT Q
Sbjct: 931 LLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQIL 990
Query: 798 PSLD 801
+++
Sbjct: 991 STIE 994
Score = 89.0 bits (219), Expect = 2e-17
Identities = 71/290 (24%), Positives = 119/290 (41%), Gaps = 21/290 (7%)
Query: 499 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 558
P++TV P+ QS GS +S +CSA + AW ++ + + ++ + G
Sbjct: 612 PKVTVMPKNQSFTGGSEVSIMCSATGYPKPKI--AWTVNDMFI----VGSHRYRMTSDGT 665
Query: 559 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 618
+ ++ G Y C+ SN G+ + L P +L + G
Sbjct: 666 LF-------IKNAAPKDAGIYGCLASNSAGTDKQ-NSTLRYIEAPKLMVVQSELLVALGD 717
Query: 619 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 678
+ +EC G P PQ+ W K D + + P + I + + D G Y+C A
Sbjct: 718 ITVMECKTSGIPPPQVKWFKG---DLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVA 774
Query: 679 QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLV 738
N AG + TL V P F++ D ++ G L C G P P + W + D+ +
Sbjct: 775 INEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPI 834
Query: 739 VTERHFFAAGNQL----LIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 784
+ ++ +QL L I++ SD G Y CE N G + ++V
Sbjct: 835 FSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV 884
Score = 79.3 bits (194), Expect = 2e-14
Identities = 74/306 (24%), Positives = 125/306 (40%), Gaps = 23/306 (7%)
Query: 490 GFVCDDFPKPQITVQ-PETQSAIKGSNLSFICSAASSSDSPMTFAWKK-DNELLHDA--E 545
G + D P + +Q P S GSN++ C + T W++ DN +
Sbjct: 783 GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEP--TIKWRRLDNMPIFSRPFS 840
Query: 546 MENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML--P 603
+ + + LR T L + + + +G Y C N FG S + +TV L P
Sbjct: 841 VSSISQLR---------TGALFILNLWASDKGTYICEAENQFGKIQS-ETTVTVTGLVAP 890
Query: 604 SFTKTPMDLTIRAGAMARLECAAV-GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 662
+P + G L C + G+P P+ W K+ + + D
Sbjct: 891 LIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAM----LLQNPYITVRSDGSLH 946
Query: 663 IVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGG 722
I V+++D G Y+C A N AG+ + ++ V P+ + +G L C A G
Sbjct: 947 IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASG 1006
Query: 723 SPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRL 782
+P P + W+K + + F A + L +V ++G+Y C +NT G + V+L
Sbjct: 1007 NPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQL 1066
Query: 783 SVIPTP 788
+V P
Sbjct: 1067 TVYVRP 1072
Score = 76.3 bits (186), Expect = 2e-13
Identities = 72/300 (24%), Positives = 113/300 (37%), Gaps = 33/300 (11%)
Query: 510 AIKGSNL---------SFICSAASSSDSPM-TFAWKKDNELLHDAEMENYAHLRAQGGEV 559
+IKG N+ S I + PM W KD + + + Y
Sbjct: 1547 SIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALY---------- 1596
Query: 560 MEYTTILRLREVEFASEGKYQCVISNHFGS---SYSVKAKLTVNMLPSFTKTPMDLTIRA 616
++ L + + + Y C ++N G+ S+ V + M+ TP++ +
Sbjct: 1597 IDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPP-MIEGNLATPLNKQVVI 1655
Query: 617 GAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 676
LEC A G+P+P + W KDG P + + I+ + D G Y C
Sbjct: 1656 AHSLTLECKAAGNPSPILTWLKDG---VPVKANDNIRIEAGGKKLEIMSAQEIDRGQYIC 1712
Query: 677 TAQNSAGSISANATLTVLETPSFLRPLLDRT----VTKGETAVLQCIAGGSPPPKLNWTK 732
A + AG + VL P+ D T V L C GSPPP + W K
Sbjct: 1713 VATSVAGEKEIKYEVDVLVPPAIEGG--DETSYFIVMVNNLLELDCHVTGSPPPTIMWLK 1770
Query: 733 DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 792
D + + + L+I + VS+ G Y C +NT G + ++V PT S
Sbjct: 1771 DGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKS 1830
Score = 74.7 bits (182), Expect = 5e-13
Identities = 68/278 (24%), Positives = 103/278 (37%), Gaps = 21/278 (7%)
Query: 499 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 558
P T P S KG L C A +T W +N ++ AH + G
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLT--WTFNNNIIP-------AHFDSVNGH 4310
Query: 559 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKT-PMDLTIRAG 617
+ L + V G Y C N G ++ + V P F P + G
Sbjct: 4311 -----SELVIERVSKEDSGTYVCTAENSVGFVKAI-GFVYVKEPPVFKGDYPSNWIEPLG 4364
Query: 618 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 677
A L C G P P I W + G + R R++ + I ED G Y+C
Sbjct: 4365 GNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLG----NGSLAIYGTVNEDAGDYTCV 4420
Query: 678 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 737
A N AG + + +LT+ P ++ + G +L C A G P P + W++ +
Sbjct: 4421 ATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSI 4480
Query: 738 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGT 775
+R N L I D+ D ++ C N +G+
Sbjct: 4481 SWDDR-VNVLSNNSLYIADAQKEDTSEFECVARNLMGS 4517
Score = 67.0 bits (162), Expect = 9e-11
Identities = 70/298 (23%), Positives = 117/298 (39%), Gaps = 22/298 (7%)
Query: 499 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 558
P+I P+ G + C+A + +T++ K + +L D E H+ G
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWS-KGGSTMLVDGEH----HVSNPDGT 1225
Query: 559 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT--KTPMDLTIR- 615
L + + + G Y CV +N G+ + L V P+ + P + T +
Sbjct: 1226 -------LSIDQATPSDAGIYTCVATNIAGTD-ETEITLHVQEPPTVEDLEPPYNTTFQE 1277
Query: 616 --AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGV 673
A C A G P P I W +G RE + ++ + + I V D G
Sbjct: 1278 RVANQRIEFPCPAKGTPKPTIKWLHNGRE--LTGREPGISILEDGTLLVIASVTPYDNGE 1335
Query: 674 YSCTAQNSAGSISANATLTVLETPSFL--RPLLDRTVTKGETAVLQCIAGGSPPPKLNWT 731
Y C A N AG+ L V P + + +V + L C G+P P + W
Sbjct: 1336 YICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY 1395
Query: 732 KDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 789
KD+ + + ++L + + DAG+Y+C+ N GT + + V+ PT
Sbjct: 1396 KDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPT 1453
Score = 60.1 bits (144), Expect = 1e-08
Identities = 55/216 (25%), Positives = 92/216 (42%), Gaps = 17/216 (7%)
Query: 663 IVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGG 722
I V + D G Y C A +SAG+ A V E P ++ + TVT GE AVL C+
Sbjct: 486 IAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIIS 545
Query: 723 SPPPKLNWTKDDSPLVVTE-RHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVR 781
+ L W ++D + + E N L + +DAG+Y C +S+ G+ +V
Sbjct: 546 AVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVF 605
Query: 782 LSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVG---TSLVWVV-----IIYHT 833
L+V + P++T + + G ++++C G + W V + H
Sbjct: 606 LTV-----QEPPKVTVMPKNQ---SFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHR 657
Query: 834 RRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQD 869
R D ++ + A I L+S D+Q+
Sbjct: 658 YRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQN 693
Score = 58.5 bits (140), Expect = 3e-08
Identities = 35/117 (29%), Positives = 54/117 (46%), Gaps = 5/117 (4%)
Query: 577 GKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 636
G Y CV +N G LT+ P T P++ I AG L C A G P P I W
Sbjct: 4415 GDYTCVATNEAGV-VERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITW 4473
Query: 637 QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTV 693
+ G + + + R++V+ + ++ I D + ED + C A+N GS+ + V
Sbjct: 4474 SRQGHS---ISWDDRVNVLSNNSLY-IADAQKEDTSEFECVARNLMGSVLVRVPVIV 4526
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 123 bits (309), Expect = 9e-28
Identities = 113/378 (29%), Positives = 186/378 (49%), Gaps = 18/378 (4%)
Query: 76 VARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA-NITLLSLAGNRIV 134
++ DLS N L+ ++ HL+ L E++L+ N L IP ++ +L L N++
Sbjct: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75
Query: 135 EILPEHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LKYLYLNSNRVTSMEPGYFDNLAN 192
I E L E SL++L L +N IS + + +F L L++L+L+ N +T + +NL
Sbjct: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP- 134
Query: 193 TLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGV 251
L + L NRIS IP F+ L L L L+ N+I+++ +F+GL L++L + N +
Sbjct: 135 ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 194
Query: 252 TKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ 311
+ A L ++ L +NN+ I + G +LQ +H N I + A+++
Sbjct: 195 QEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLP 253
Query: 312 KLSELDLTFNHLSRLDDSSF---LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKN 368
KL L L +D F G + L L + + + + L L+ L+L +
Sbjct: 254 KLHTLSLN----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSH 309
Query: 369 NEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN 428
N+I E++ + KL + LQ NRI I F+ L +L+ LDLS NAI S+
Sbjct: 310 NQI----EELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 364
Query: 429 AFSQMKKLQQLHLNTSSL 446
AFS + L +L L + L
Sbjct: 365 AFSTLHSLVKLDLTDNQL 382
Score = 85.9 bits (211), Expect = 2e-16
Identities = 81/300 (27%), Positives = 140/300 (46%), Gaps = 12/300 (4%)
Query: 74 SWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNR 132
S + L L N L+ I ++++L +L+ + L N + IP+ + ++ +L L NR
Sbjct: 110 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR 169
Query: 133 IVEILPEHLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLA 191
I + + +LETLDL+ N + E A L +L+ L ++N + ++ F +
Sbjct: 170 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAF--MG 227
Query: 192 NTLL-VLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRN 249
N LL + N I + F+ LP+L L LN + + +G +L+ L + R
Sbjct: 228 NPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRA 286
Query: 250 GVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEF 309
G+ L G L + +L+L HN + E+ L+ L+E+ L N I I D +
Sbjct: 287 GIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQ 344
Query: 310 CQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 369
L LDL++N + + +F L L L + +N+++ + GL L L LK N
Sbjct: 345 LSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGN 401
Score = 73.6 bits (179), Expect = 1e-12
Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 3/160 (1%)
Query: 287 LMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNR 346
+++ LS N + + P + + L EL L+ NHLS + +F GL L L + NN+
Sbjct: 14 IIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 73
Query: 347 VSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAF 406
+ I A L SL++L L N IS E +F GL LR L L N + I +A
Sbjct: 74 LGGIPAEALWELPSLQSLRLDANLISLVPE---RSFEGLSSLRHLWLDDNALTEIPVRAL 130
Query: 407 TGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
L AL+ + L+ N I + AF + L LHL+ + +
Sbjct: 131 NNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRI 170
Score = 58.5 bits (140), Expect = 3e-08
Identities = 67/247 (27%), Positives = 110/247 (44%), Gaps = 32/247 (12%)
Query: 79 LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP----------NLGPVSANITLL-- 126
L L +NR+ + S L +L + LN N+L+ P LG + NI +
Sbjct: 163 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPE 222
Query: 127 -SLAGNRIVEILPEH--------LKEFQSLETLD-LSSNNISELQTAFPALQ----LKYL 172
+ GN +++ + + FQ L L LS N ++Q FP L+ L+ L
Sbjct: 223 KAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE-FPDLKGTTSLEIL 281
Query: 173 YLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDG 232
L + + G L L VL+L+ N+I +P + + +L+ + L N+I +
Sbjct: 282 TLTRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGA 339
Query: 233 LTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQ-- 290
TF L +L++L + N + + AF L ++ L L N LT + L GL+ L+
Sbjct: 340 DTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLK 399
Query: 291 -ELHLSQ 296
L LSQ
Sbjct: 400 GNLALSQ 406
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 121 bits (304), Expect = 3e-27
Identities = 104/375 (27%), Positives = 171/375 (45%), Gaps = 21/375 (5%)
Query: 218 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 277
++L L N I+ + TF+ L L+ L++ RN + ++ GAF GL+++ L+L N LT
Sbjct: 78 RYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTV 137
Query: 278 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSL 336
I G L L+EL L N I I A+ L LDL L + + +F GL
Sbjct: 138 IPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFN 197
Query: 337 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN 396
L L++G + + + L L+ L++ N E G+F GL L++L + +
Sbjct: 198 LKYLNLGMCNIKDMPNLT--PLVGLEELEMSGNHFP---EIRPGSFHGLSSLKKLWVMNS 252
Query: 397 RIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLP 456
++ I + AF GL +L L+L+ N + SL + F+ ++ L +LHL+ + CDC + WL
Sbjct: 253 QVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLA 312
Query: 457 QWVAEN-NFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSN 515
W+ E S C P ++GR + V F C P I P + +G
Sbjct: 313 WWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCS---APFIMDAPRDLNISEGRM 369
Query: 516 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 575
C S + W LL + + ++A + + + T L V +
Sbjct: 370 AELKCRTPPMS----SVKW-----LLPNGTVLSHASRHPRISVLNDGT--LNFSHVLLSD 418
Query: 576 EGKYQCVISNHFGSS 590
G Y C+++N G+S
Sbjct: 419 TGVYTCMVTNVAGNS 433
Score = 88.2 bits (217), Expect = 4e-17
Identities = 77/266 (28%), Positives = 124/266 (46%), Gaps = 10/266 (3%)
Query: 42 AAERPCPTTCRCLGDL--LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQS 99
A + CP+ C C + C+R+ L+ +P+ +PS L+L N + I+A + HL
Sbjct: 41 AGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHH 100
Query: 100 LREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNI 157
L ++L N + I +G + A++ L L N + I + L L L +N I
Sbjct: 101 LEVLQLGRNSIRQI-EVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPI 159
Query: 158 SELQT-AFPAL-QLKYLYLNS-NRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKL 214
+ + AF + L L L ++ + G F+ L N L L L I +P + L
Sbjct: 160 ESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFN-LKYLNLGMCNIKDMP-NLTPL 217
Query: 215 PQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNN 274
L+ LE++ N + +F GL +LK L + + V+ + AF GL+++ L L HNN
Sbjct: 218 VGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNN 277
Query: 275 LTEITKGWLYGLLMLQELHLSQNAIN 300
L+ + L L ELHL N N
Sbjct: 278 LSSLPHDLFTPLRYLVELHLHHNPWN 303
Score = 52.4 bits (124), Expect = 2e-06
Identities = 71/272 (26%), Positives = 107/272 (39%), Gaps = 47/272 (17%)
Query: 603 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFP-AARERRMHVMPEDDVF 661
P P DL I G MA L+C P + W GT A+R R+ V+ + +
Sbjct: 353 PFIMDAPRDLNISEGRMAELKCRTP--PMSSVKWLLPNGTVLSHASRHPRISVLNDGTLN 410
Query: 662 FIVDVKIEDIGVYSCTAQNSAGSISANATLTV----LETPSFLRPLLDRTVTKGETAVLQ 717
F V + D GVY+C N AG+ +A+A L V L T ++ TVT T +
Sbjct: 411 FS-HVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNY---SFFTTVTVETTEI-- 464
Query: 718 CIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTER 777
SP + T+ P+ T + A YT + + T R
Sbjct: 465 -----SPE---DTTRKYKPVPTTSTGYQPA-----------------YTTSTTVLIQTTR 499
Query: 778 GNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRN 837
+++V T T D Q SLD+ T +II V + +++ Y R+R+
Sbjct: 500 VPKQVAVPATDTTDKMQ---TSLDEVMKTT--KIIIGCFVAVTLLAAAMLIVFYKLRKRH 554
Query: 838 EDCSITNTDET----NLPADIPSYLSSQGTLA 865
+ S T + DIP+ S+ T A
Sbjct: 555 QQRSTVTAARTVEIIQVDEDIPAATSAAATAA 586
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 121 bits (303), Expect = 4e-27
Identities = 120/410 (29%), Positives = 194/410 (47%), Gaps = 35/410 (8%)
Query: 45 RPCPTTCRCLGD-----LLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQS 99
R CPT C C D +DCS L+ LP L + + LDLS N +S + + + L+
Sbjct: 32 RGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRF 91
Query: 100 LREVKLNNNELETIPNLGPVSA--NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNI 157
L E++L N L IP G + ++ +L L N++ + E L+ +SL++L L +N+I
Sbjct: 92 LEELRLAGNALTYIPK-GAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHI 150
Query: 158 SELQ-TAFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KL 214
S + + F L L++L+L+ N +T + F +L+ L + L N+I IP F L
Sbjct: 151 SYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLS-ALQAMTLALNKIHHIPDYAFGNL 209
Query: 215 PQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNN 274
L L L+ N+I ++ F GL +L++L + N + + A LSN++ L NN
Sbjct: 210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPT-AIRTLSNLKELGFHSNN 268
Query: 275 LTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFL-G 333
+ I + G L +H N I + A++ +L L T N S++ + L G
Sbjct: 269 IRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTL--TLNGASQITEFPDLTG 326
Query: 334 LSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEI----SWTI-------------- 375
+ L +L + ++S + L +L+ LDL N + S+++
Sbjct: 327 TANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEI 386
Query: 376 -EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMS 424
E F L LR L L N+I I AF+ L +L LDLS N + S
Sbjct: 387 YEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSS 436
Score = 118 bits (295), Expect = 4e-26
Identities = 96/348 (27%), Positives = 164/348 (47%), Gaps = 31/348 (8%)
Query: 119 VSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNS 176
+S + L L+ N I ++LP L + LE L L+ N ++ + + AF L LK L L +
Sbjct: 64 LSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQN 123
Query: 177 NRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTF 235
N++ + NL +L L+L+ N IS +PP F L L+HL L+ N + + F
Sbjct: 124 NQLRHVPTEALQNL-RSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAF 182
Query: 236 QGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLS 295
+ L AL+++ + N + + D AF LS++ +L L +N + + K GL L+ L L+
Sbjct: 183 RSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLN 242
Query: 296 QNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAF 355
N ++ P A L EL N++ + + +F+G L T+H +N + ++ AF
Sbjct: 243 YNNLDEF-PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAF 301
Query: 356 RGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKK----------- 404
+ L L+TL L D+ G + L L L G +I S+ +
Sbjct: 302 QHLPELRTLTLNGASQITEFPDLTGTAN----LESLTLTGAQISSLPQTVCNQLPNLQVL 357
Query: 405 -----------AFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHL 441
+F+ L+ +DL N I ++ + F Q+ L+ L+L
Sbjct: 358 DLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNL 405
Score = 117 bits (293), Expect = 6e-26
Identities = 96/316 (30%), Positives = 144/316 (45%), Gaps = 25/316 (7%)
Query: 189 NLANTLLVLKLNRNRISAIPPKMFKLPQLQHLE---LNRNKIKNVDGLTFQGLGALKSLK 245
NL+ L L+ N IS + P LP L+ LE L N + + F GL +LK L
Sbjct: 63 NLSVFTSYLDLSMNNISQLLPN--PLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLM 120
Query: 246 MQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPD 305
+Q N + + A L +++ L+LD N+++ + GL L+ L L NA+ I
Sbjct: 121 LQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQ 180
Query: 306 AWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLD 365
A+ L + L N + + D +F LS L LH+ NNR+ + F GL SL+TLD
Sbjct: 181 AFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLD 240
Query: 366 LKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSL 425
L N +++ A L L+ L N IRSI +KAF G +L + DN I +
Sbjct: 241 LNYN----NLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFV 296
Query: 426 QGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFA 485
+AF + +L+ L LN +S Q+ P N +S L G I +
Sbjct: 297 GRSAFQHLPELRTLTLNGAS-----QITEFPDLTGTANLESLT---------LTGAQISS 342
Query: 486 VSPDGFVCDDFPKPQI 501
+ VC+ P Q+
Sbjct: 343 LPQT--VCNQLPNLQV 356
Score = 109 bits (273), Expect = 1e-23
Identities = 100/336 (29%), Positives = 154/336 (45%), Gaps = 35/336 (10%)
Query: 137 LPEHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTL 194
LP +L F S LDLS NNIS+L P+L+ L+ L L N +T + G F L + L
Sbjct: 60 LPSNLSVFTSY--LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYS-L 116
Query: 195 LVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK 253
VL L N++ +P + + L LQ L L+ N I V F GL +L+ L + N +T+
Sbjct: 117 KVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTE 176
Query: 254 LMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKL 313
+ AF LS ++ + L N + I L L LHL N I+ + ++ L
Sbjct: 177 IPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSL 236
Query: 314 SELDLTFNHLSR-----------------------LDDSSFLGLSLLNTLHIGNNRVSYI 350
LDL +N+L + + +F+G L T+H +N + ++
Sbjct: 237 ETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFV 296
Query: 351 ADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLD 410
AF+ L L+TL L D+ G + L L L G +I S+ + L
Sbjct: 297 GRSAFQHLPELRTLTLNGASQITEFPDLTGTAN----LESLTLTGAQISSLPQTVCNQLP 352
Query: 411 ALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
L+ LDLS N + L +FS +KLQ++ L + +
Sbjct: 353 NLQVLDLSYNLLEDLP--SFSVCQKLQKIDLRHNEI 386
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 120 bits (302), Expect = 6e-27
Identities = 86/291 (29%), Positives = 129/291 (44%), Gaps = 15/291 (5%)
Query: 499 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 558
P I P ++ ++ ++++ C A S P +W K ++ + G
Sbjct: 695 PNIEPGPVNKAVLENASVTLECLA--SGVPPPDVSWFKGHQPVSSW----------MGVT 742
Query: 559 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-MDLTIRAG 617
V +LR+ + + + G Y+CV SN GS+ ++ L VN+ P T P + +
Sbjct: 743 VSVDGRVLRIEQAQLSDAGSYRCVASNVAGST-ELRYGLRVNVPPRITLPPSLPGPVLVN 801
Query: 618 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 677
RL C A G P+P + W KDG PA + V P V + + D G YSC
Sbjct: 802 TPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG-LQVFPGGRVLTLASARASDSGRYSCV 860
Query: 678 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 737
A ++ G + L V PS L L+ +V E+ L+C + PPP L+W KD PL
Sbjct: 861 AVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPL 920
Query: 738 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788
+A LL + +DV DAG YTCE N G + L+V P
Sbjct: 921 EPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAP 971
Score = 114 bits (285), Expect = 5e-25
Identities = 77/269 (28%), Positives = 120/269 (44%), Gaps = 18/269 (6%)
Query: 533 AWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS 592
+W+KD + L E H+ A G +L L + + A EG Y C SN G+S S
Sbjct: 1004 SWRKDGQPL-PGEGAGLQHVSAVG-------RLLYLGQAQLAQEGTYTCECSNVVGNS-S 1054
Query: 593 VKAKLTVNMLPSFT---KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARE 649
+L V++ P + P +++ +A LEC A G P P + W++DG P E
Sbjct: 1055 QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ---PVGAE 1111
Query: 650 RRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSF---LRPLLDR 706
+ + + + + G YSC A+N AG L+VL P L PL +
Sbjct: 1112 LGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI 1171
Query: 707 TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYT 766
T L C A G PPP + W + + P+ E + AG +L + + D+G Y+
Sbjct: 1172 TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYS 1231
Query: 767 CEMSNTLGTERGNVRLSVIPTPTCDSPQM 795
C SN G R N + V+ P+ ++ +
Sbjct: 1232 CLASNEAGEARRNFSVEVLVPPSIENEDL 1260
Score = 106 bits (265), Expect = 1e-22
Identities = 83/292 (28%), Positives = 133/292 (45%), Gaps = 22/292 (7%)
Query: 504 QPETQ-SAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEY 562
+P TQ S ++ + C+A P T W++D + + AE+ G ++
Sbjct: 1072 EPPTQVSVVQDGVATLECNATGKP--PPTVTWERDGQPV-GAEL---------GLQLQNQ 1119
Query: 563 TTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAM--- 619
L + + A G+Y CV N G + K +L+V + P LT A+
Sbjct: 1120 GQSLHVERAQAAHTGRYSCVAENLAGRAER-KFELSVLVPPELIGDLDPLTNITAALHSP 1178
Query: 620 ARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQ 679
L C A+G P P I W + + P + +++ + + + +D G+YSC A
Sbjct: 1179 LTLLCEAMGIPPPAIRWFRG---EEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS 1235
Query: 680 NSAGSISANATLTVLETPSFLRPLLDRT--VTKGETAVLQCIAGGSPPPKLNWTKDDSPL 737
N AG N ++ VL PS L+ V G+TA L C G P PKL W KD PL
Sbjct: 1236 NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 1295
Query: 738 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 789
+ H + LL ++ +++S AG Y+C +N +G + + +LSV+ PT
Sbjct: 1296 ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT 1347
Score = 106 bits (265), Expect = 1e-22
Identities = 71/242 (29%), Positives = 111/242 (45%), Gaps = 9/242 (3%)
Query: 558 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD-LTIRA 616
+V+E +L++ E A Y CV N GS+ + L V + P ++ +T
Sbjct: 1702 QVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT-LRVQVPPRIAGLDLEQVTAIL 1760
Query: 617 GAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 676
+ L C HP P++ W KD + + ++P + ++ D G+Y+C
Sbjct: 1761 NSSVSLPCDVHAHPNPEVTWYKDSQA---LSLGEEVFLLPGTHTLQLGRARLSDSGMYTC 1817
Query: 677 TAQNSAGSISANATLTVLETPSFLR----PLLDRTVTKGETAVLQCIAGGSPPPKLNWTK 732
A N+AG L+VL P+F + P V G+ AVL C P P + W K
Sbjct: 1818 EALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK 1877
Query: 733 DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 792
D PLV+ +R G Q L I ++ VSD G Y+C++SN G L+V PT ++
Sbjct: 1878 DGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFEN 1937
Query: 793 PQ 794
P+
Sbjct: 1938 PK 1939
Score = 106 bits (264), Expect = 1e-22
Identities = 69/234 (29%), Positives = 107/234 (45%), Gaps = 15/234 (6%)
Query: 565 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML--PSFTKTPMDLTIRA--GAMA 620
+L++ + + G Y C+ SN G + + +V +L PS ++ I+ G A
Sbjct: 1216 MLKMTQTQEQDSGLYSCLASNEAGEA---RRNFSVEVLVPPSIENEDLEEVIKVLDGQTA 1272
Query: 621 RLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQN 680
L C GHP P++ W KDG P AR H+ P+ + ++ + G YSC A N
Sbjct: 1273 HLMCNVTGHPQPKLTWFKDGR---PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1329
Query: 681 SAGSISANATLTVLETPSFLRPLLDR-----TVTKGETAVLQCIAGGSPPPKLNWTKDDS 735
+ G + + L+VL P+ L D TVT L C A P P + W KD +
Sbjct: 1330 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1389
Query: 736 PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 789
P + G L I+++ DAG+YTC ++N LG N + V+ P+
Sbjct: 1390 PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 1443
Score = 105 bits (261), Expect = 3e-22
Identities = 122/478 (25%), Positives = 184/478 (38%), Gaps = 75/478 (15%)
Query: 446 LLCDCQLKWLPQ--WVAENNFQSFVNASCAHPQLLKGR-----SIFAVSPDGFVCDDF-- 496
LLCD Q P W + + + + ++L+ R + A SP G + F
Sbjct: 2324 LLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRV 2383
Query: 497 --PKPQITVQPETQSAIKG---SNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAH 551
P V P + G L CS + +T W +D +L + AH
Sbjct: 2384 RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT--WHRDGIVLQED-----AH 2436
Query: 552 LRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD 611
+ E L+L+ + A G Y C N GS+ SV ++ ++ +P+ P
Sbjct: 2437 T-----QFPERGRFLQLQALSTADSGDYSCTARNAAGST-SVAFRVEIHTVPTIRSGPPA 2490
Query: 612 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 671
+ + A L C A G PAP ++W+KD P R R ++PE + I V +D
Sbjct: 2491 VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDP--RSPRFEILPEGSLR-IQPVLAQDA 2547
Query: 672 GVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWT 731
G Y C A NSAGS L VLE P+ + T+T A+L C A GSP P + W
Sbjct: 2548 GHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWW 2607
Query: 732 KDDSPL--VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 789
KD L + + + + L++ D+ ++ C +SN +G +++V PT
Sbjct: 2608 KDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2667
Query: 790 CDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETN 849
DD TV ++ V+ C T
Sbjct: 2668 I---------ADDQTDFTVTMMAPVVLTC---------------------------HSTG 2691
Query: 850 LPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSS 907
+PA S+ + L R GY S SG+ G LP H TC NS+
Sbjct: 2692 IPAPTVSWSKAGAQLGARGSGYRVSPSGALE-------IGQALPIHAGRYTCSARNSA 2742
Score = 104 bits (260), Expect = 4e-22
Identities = 67/209 (32%), Positives = 97/209 (46%), Gaps = 6/209 (2%)
Query: 566 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 625
LR+ G Y C+ N GS+ K +L V + P DL+ G+ A L C
Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGSAMG-KTRLVVQVPPVIENGLPDLSTTEGSHAFLPCK 2869
Query: 626 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 685
A G P P I W KDG + E + + P ++ + +++ +D G Y+CTA+N+ G
Sbjct: 2870 ARGSPEPNITWDKDGQP--VSGAEGKFTIQPSGELL-VKNLEGQDAGTYTCTAENAVGRA 2926
Query: 686 SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 745
LT+L P F DR++ G+ L+C A GSP P++ WT +D P VTE
Sbjct: 2927 RRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP--VTEGVSE 2984
Query: 746 AAGNQLLIIVDSDVSDAGKYTCEMSNTLG 774
G L D+G Y C N +G
Sbjct: 2985 QDGGSTLQRAAVSREDSGTYVCWAENRVG 3013
Score = 104 bits (259), Expect = 5e-22
Identities = 71/212 (33%), Positives = 92/212 (43%), Gaps = 5/212 (2%)
Query: 577 GKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 636
G+Y C N G ++ LTV P P + A L C A G P P I W
Sbjct: 2732 GRYTCSARNSAGVAHK-HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW 2790
Query: 637 QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLET 696
QK+G A V+P + I ED G Y C A+NSAGS L V
Sbjct: 2791 QKEG---LNVATGVSTQVLPGGQLR-IAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVP 2846
Query: 697 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVD 756
P L D + T+G A L C A GSP P + W KD P+ E F + L++ +
Sbjct: 2847 PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKN 2906
Query: 757 SDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788
+ DAG YTC N +G R V L+++ P
Sbjct: 2907 LEGQDAGTYTCTAENAVGRARRRVHLTILVLP 2938
Score = 93.2 bits (230), Expect = 1e-18
Identities = 83/294 (28%), Positives = 125/294 (42%), Gaps = 25/294 (8%)
Query: 506 ETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTI 565
ET S + GS L C S +P T W KD + + + ++GG
Sbjct: 1941 ETVSQVAGSPLVLTCDV-SGVPAP-TVTWLKDRMPVESSAVHGVV---SRGGR------- 1988
Query: 566 LRLREVEFASEGKYQCVISNHFGSSYS--VKAKLTVNMLPSFTKTPMDLTIRAGAMARLE 623
L+L ++ A G Y CV N + V A L + S + + + G RL+
Sbjct: 1989 LQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS-SGVAREHHVLEGQEVRLD 2047
Query: 624 CAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIV--DVKIEDIGVYSCTAQNS 681
C A G P P +AW KDG P ++ H+ D +V ++ D G Y+C A N
Sbjct: 2048 CEADGQPPPDVAWLKDGS---PLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNP 2104
Query: 682 AGSISANATLTVLETPSFLRPLLDRTVT----KGETAVLQCIAGGSPPPKLNWTKDDSPL 737
AG + T+ VL P+ ++ D + T GE + C GSPP ++W KD PL
Sbjct: 2105 AGEDARLHTVNVLVPPT-IKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL 2163
Query: 738 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCD 791
+++R L I ++DAG +TC ++ G N L V P +
Sbjct: 2164 PLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLE 2217
Score = 92.4 bits (228), Expect = 2e-18
Identities = 69/227 (30%), Positives = 101/227 (44%), Gaps = 7/227 (3%)
Query: 566 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 625
L++ +V+ EG Y C +N G S A L V + P+ P++ + A LEC
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVTLECL 717
Query: 626 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 685
A G P P ++W K P + + V + V I ++ D G Y C A N AGS
Sbjct: 718 ASGVPPPDVSWFKGHQ---PVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 774
Query: 686 SANATLTVLETPSF-LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL--VVTER 742
L V P L P L V L C A G+P P L W KD +P+ T
Sbjct: 775 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG 834
Query: 743 HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 789
G ++L + + SD+G+Y+C + +G +R +V L V P+
Sbjct: 835 LQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 881
Score = 90.9 bits (224), Expect = 6e-18
Identities = 78/272 (28%), Positives = 120/272 (44%), Gaps = 18/272 (6%)
Query: 523 ASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCV 582
AS S P+ WK +L D ++ QG + + L L +++CV
Sbjct: 2596 ASGSPKPLVVWWKDGQKL--DFRLQ-------QGAYRLLPSNALLLTAPGPQDSAQFECV 2646
Query: 583 ISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGT 642
+SN G ++ + ++TV++ P+ D T+ A L C + G PAP ++W K G
Sbjct: 2647 VSNEVGEAHRLY-QVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 2705
Query: 643 DFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRP 702
AR V P + + I G Y+C+A+NSAG + LTV +P ++P
Sbjct: 2706 --LGARGSGYRVSPSGALEIGQALPIH-AGRYTCSARNSAGVAHKHVFLTVQASP-VVKP 2761
Query: 703 L--LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS 760
L + R V + E +L C A G P P + W K+ + G QL I +
Sbjct: 2762 LPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRI-AHASPE 2819
Query: 761 DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 792
DAG Y C N+ G+ G RL V P ++
Sbjct: 2820 DAGNYLCIAKNSAGSAMGKTRLVVQVPPVIEN 2851
Score = 89.7 bits (221), Expect = 1e-17
Identities = 76/294 (25%), Positives = 112/294 (38%), Gaps = 18/294 (6%)
Query: 499 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 558
P I + S + +++ C S + P +W KD L E HL A
Sbjct: 880 PSILGEELNVSVVANESVALECQ--SHAMPPPVLSWWKDGRPL---EPRPGVHLSAD--- 931
Query: 559 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT-KTPMDLTIRAG 617
+L++ + G Y C N G S L V + P F + LT+R G
Sbjct: 932 ----KALLQVDRADVWDAGHYTCEALNQAGRSEK-HYNLNVWVAPVFPLRESHTLTVREG 986
Query: 618 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 677
L C G P P+I+W+KD G P HV + ++ ++ G Y+C
Sbjct: 987 HPTSLSCECRGVPFPKISWRKD-GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 1045
Query: 678 AQNSAGSISANATLTVLETPSFLRPLLDRT---VTKGETAVLQCIAGGSPPPKLNWTKDD 734
N G+ S + L V P P T V + A L+C A G PPP + W +D
Sbjct: 1046 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDG 1105
Query: 735 SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788
P+ Q L + + + G+Y+C N G LSV+ P
Sbjct: 1106 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPP 1159
Score = 86.3 bits (212), Expect = 2e-16
Identities = 74/300 (24%), Positives = 120/300 (40%), Gaps = 43/300 (14%)
Query: 516 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 575
+S IC A + +T W KD A E +++ G T L++ +
Sbjct: 1368 ISLICEALAFPSPNIT--WMKDG-----APFEASRNIQLLPG-----THGLQILNAQKED 1415
Query: 576 EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-------MDLTIRAGAMARLECAAVG 628
G+Y CV++N G + + V + PS +K ++ + + LEC +
Sbjct: 1416 AGQYTCVVTNELGEAVK-NYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWA 1474
Query: 629 HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 688
P P I W KDG P R+ V+ E + I ++ D G Y C A N AG +
Sbjct: 1475 VPPPTIRWYKDGQ---PVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD 1531
Query: 689 ATLTVLETPSFLR--------PLLDRT------------VTKGETAVLQCIAGGSPPPKL 728
+ + P F + +L R + + A L C PPP L
Sbjct: 1532 FNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDL 1591
Query: 729 NWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788
W ++D PL + G ++L I +AG+Y+C+ SN +G + + L V+ P
Sbjct: 1592 TWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPP 1651
Score = 84.3 bits (207), Expect = 6e-16
Identities = 62/223 (27%), Positives = 95/223 (42%), Gaps = 2/223 (0%)
Query: 566 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 625
LR++ V G Y C+ SN GS + L V P+ +P +LT+ A A L C
Sbjct: 2537 LRIQPVLAQDAGHYLCLASNSAGSDRQGR-DLRVLEPPAIAPSPSNLTLTAHTPALLPCE 2595
Query: 626 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 685
A G P P + W KDG ++ ++P + + +D + C N G
Sbjct: 2596 ASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGP-QDSAQFECVVSNEVGEA 2654
Query: 686 SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 745
+TV P+ D TVT VL C + G P P ++W+K + L +
Sbjct: 2655 HRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYR 2714
Query: 746 AAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788
+ + L I + AG+YTC N+ G +V L+V +P
Sbjct: 2715 VSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP 2757
Score = 83.2 bits (204), Expect = 1e-15
Identities = 82/311 (26%), Positives = 121/311 (38%), Gaps = 26/311 (8%)
Query: 485 AVSPDGFVCDDFP-----KPQITVQPET-QSAIKGSNLSFICSAASSSDSPMTFAWKKDN 538
A SP G DF P I ET + A+ +L + A +P W KD
Sbjct: 291 AFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP-NITWFKDG 349
Query: 539 ELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLT 598
LL + Y +GG L+L + + G Y C SN G++ +L
Sbjct: 350 ALLPTSTKVVYT----RGGRQ------LQLGRAQSSDAGVYTCKASNAVGAAEKA-TRLD 398
Query: 599 VNMLPSFTKT---PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVM 655
V + P+ P + AG LEC A GHP+P ++W +G P A +
Sbjct: 399 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG---LPVAESNESRLE 455
Query: 656 PEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFL--RPLLDRTVTKGET 713
+ V + G+YSC A + AG ++ V P L L T G+
Sbjct: 456 TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQP 515
Query: 714 AVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTL 773
L C A GSP P + W ++ P A+ L I ++ +G + C+ +N
Sbjct: 516 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 575
Query: 774 GTERGNVRLSV 784
GT V +SV
Sbjct: 576 GTAGAEVEVSV 586
Score = 83.2 bits (204), Expect = 1e-15
Identities = 83/320 (25%), Positives = 124/320 (38%), Gaps = 40/320 (12%)
Query: 485 AVSPDGFVCDDFPKPQITVQPETQSA--------IKGSNLSFICSAASSSDSPMTFAWKK 536
A SP G +F Q+ V P + ++GS + C A P+ +W K
Sbjct: 2195 AASPAGVADRNFTL-QVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVP-LPLV-SWMK 2251
Query: 537 DNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAK 596
D E L +E QG L+L V G Y CV + G + +
Sbjct: 2252 DGEPLLSQSLE-------QGPS-------LQLEAVGAGDSGTYSCVAVSEAGEARR-HFQ 2296
Query: 597 LTVNMLPSFTKT--PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHV 654
LTV P + P +L++ GA L C A G P P I W KDG R
Sbjct: 2297 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATR 2356
Query: 655 MPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVT--KGE 712
+ +++ D G+Y+C A++ AG+I + + V P+ + P R V
Sbjct: 2357 V----------LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPG 2406
Query: 713 TAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 772
VL+C P PK+ W +D L F + L + +D+G Y+C N
Sbjct: 2407 QLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 2466
Query: 773 LGTERGNVRLSVIPTPTCDS 792
G+ R+ + PT S
Sbjct: 2467 AGSTSVAFRVEIHTVPTIRS 2486
Score = 80.9 bits (198), Expect = 6e-15
Identities = 56/183 (30%), Positives = 79/183 (43%), Gaps = 14/183 (7%)
Query: 616 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 675
AGA L+C G P PQ+ W KD P + V + V I + D G Y
Sbjct: 231 AGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPH--LQVQEDGQVLRITGSHVGDEGRYQ 288
Query: 676 CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQ-------CIAGGSPPPKL 728
C A + AG + + L V P+ + GE AV++ C A G P P +
Sbjct: 289 CVAFSPAGQQARDFQLRVHAPPTIWG-----SNETGEVAVMEDHLVQLLCEARGVPTPNI 343
Query: 729 NWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788
W KD + L + + + G + L + + SDAG YTC+ SN +G RL V P
Sbjct: 344 TWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPP 403
Query: 789 TCD 791
T +
Sbjct: 404 TIE 406
Score = 79.7 bits (195), Expect = 1e-14
Identities = 76/299 (25%), Positives = 108/299 (36%), Gaps = 21/299 (7%)
Query: 499 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 558
P T P +S G L C AA S +P W ++ + + E GG
Sbjct: 2938 PVFTTLPGDRSLRLGDRLWLRC-AARGSPTPR-IGWTVNDRPVTEGVSEQ------DGGS 2989
Query: 559 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR-AG 617
++ + R G Y C N G + +V + V P + G
Sbjct: 2990 TLQRAAVSR------EDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQGEAFSYLVEPVG 3042
Query: 618 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 677
+L+C G P P I W KDG P H + ++ I + +D G Y C
Sbjct: 3043 GSIQLDCVVRGDPVPDIHWIKDG---LPLRGSHLRHQL-QNGSLTIHRTERDDAGRYQCL 3098
Query: 678 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 737
A+N G L + P F D TV G+ L+C A G P P + W + PL
Sbjct: 3099 AENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 3158
Query: 738 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMT 796
+ R + L + + + DAG Y C N LG+ L V P MT
Sbjct: 3159 RAS-RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMT 3216
Score = 74.7 bits (182), Expect = 5e-13
Identities = 67/264 (25%), Positives = 107/264 (40%), Gaps = 27/264 (10%)
Query: 556 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS-VKAKLTVNMLPSFTKTPMDL-- 612
G +V T L + VE G + C +N G++ + V+ + P + P+
Sbjct: 544 GVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYH 603
Query: 613 -------TIRAGAMARLECAAVGHPAPQIA--WQKDGG-----TDFPAARERRMHVMPED 658
+ A + HP P + W G T P A + +P
Sbjct: 604 WGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVA-----YSLPPP 658
Query: 659 DVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQC 718
I V + D G+Y+C A N AG L VL P+ +++ V + + L+C
Sbjct: 659 --LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLEC 716
Query: 719 IAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTE-- 776
+A G PPP ++W K P+ + ++L I + +SDAG Y C SN G+
Sbjct: 717 LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 776
Query: 777 RGNVRLSVIPTPTCDSPQMTAPSL 800
R +R++V P T P + P L
Sbjct: 777 RYGLRVNVPPRITL-PPSLPGPVL 799
Score = 72.4 bits (176), Expect = 2e-12
Identities = 58/228 (25%), Positives = 93/228 (40%), Gaps = 21/228 (9%)
Query: 558 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLTIR 615
+V E +LR+ EG+YQCV + G + +L V+ P+ + ++ +
Sbjct: 266 QVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVM 324
Query: 616 AGAMARLECAAVGHPAPQIAWQKDGG-----TDFPAARERRMHVMPEDDVFFIVDVKIED 670
+ +L C A G P P I W KDG T R R + + D
Sbjct: 325 EDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGR--------AQSSD 376
Query: 671 IGVYSCTAQNSAGSISANATLTVLETPSFL----RPLLDRTVTKGETAVLQCIAGGSPPP 726
GVY+C A N+ G+ L V P+ RP + + V G L+C+A G P P
Sbjct: 377 AGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA-GRPVALECVARGHPSP 435
Query: 727 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLG 774
L+W + P+ + +L + + +G Y+C S+ G
Sbjct: 436 TLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAG 483
Score = 72.0 bits (175), Expect = 3e-12
Identities = 73/296 (24%), Positives = 114/296 (38%), Gaps = 41/296 (13%)
Query: 529 PMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFG 588
P T W KD + + + +V+ +L+++ + + G+Y CV +N G
Sbjct: 1477 PPTIRWYKDGQPVTPSSRL----------QVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 1526
Query: 589 SSYSVKAKLTVNMLPSFTKT----------PMDLTIRAGAM----------ARLECAAVG 628
+ + + P F K + R G A L C
Sbjct: 1527 ED-DQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNA 1585
Query: 629 HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 688
P P + W ++ D P + + V+ V I V+ E+ G YSC A N G +
Sbjct: 1586 IPPPDLTWYRE---DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1642
Query: 689 ATLTVLETPSFL---RPLLDR-TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHF 744
L VL P L L++ TV T LQC A G+P P ++W ++ P + R
Sbjct: 1643 YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQ 1702
Query: 745 FAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT---CDSPQMTA 797
Q+L + ++V+DA Y C N G+ L V P D Q+TA
Sbjct: 1703 VLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 1758
Score = 71.2 bits (173), Expect = 5e-12
Identities = 72/268 (26%), Positives = 99/268 (36%), Gaps = 31/268 (11%)
Query: 552 LRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD 611
L Q G + L L V A G Y+C +N GS+ S +AKL V + PS +
Sbjct: 45 LHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST-SRRAKLVVYVPPSIREDGRK 103
Query: 612 LTIR--AGAMARLECAAVGHPAPQIAWQKDG------------GTDFPAARERRMHVMPE 657
+ AG LEC A G P P+I W KD G D + ++ E
Sbjct: 104 ANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE 163
Query: 658 DDVFFIVDVKIEDIGVYSC----TAQNSAGSISANATLTVLETPSFLRPLLDRTV----- 708
++ G +AQ A + A TP P +V
Sbjct: 164 GQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGA 223
Query: 709 ------TKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHF-FAAGNQLLIIVDSDVSD 761
G LQC G P P++ WTKD P++ H Q+L I S V D
Sbjct: 224 AQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGD 283
Query: 762 AGKYTCEMSNTLGTERGNVRLSVIPTPT 789
G+Y C + G + + +L V PT
Sbjct: 284 EGRYQCVAFSPAGQQARDFQLRVHAPPT 311
Score = 60.5 bits (145), Expect = 9e-09
Identities = 38/112 (33%), Positives = 52/112 (46%), Gaps = 4/112 (3%)
Query: 624 CAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAG 683
C G P PQ+ W+K G + P + + V+ E +F + V D G Y C A N G
Sbjct: 24 CGTHGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGSLF-LASVSPADSGDYECQATNEVG 81
Query: 684 SISANATLTVLETPSFLRPLLDRTVT--KGETAVLQCIAGGSPPPKLNWTKD 733
S S A L V PS V+ G++ L+C A G P P++ W KD
Sbjct: 82 STSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKD 133
Score = 31.2 bits (69), Expect = 5.7
Identities = 18/73 (24%), Positives = 33/73 (45%), Gaps = 1/73 (1%)
Query: 718 CIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQ-LLIIVDSDVSDAGKYTCEMSNTLGTE 776
C G+P P++ W K S + + A + L + +D+G Y C+ +N +G+
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83
Query: 777 RGNVRLSVIPTPT 789
+L V P+
Sbjct: 84 SRRAKLVVYVPPS 96
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,573,311
Number of Sequences: 37866
Number of extensions: 2125184
Number of successful extensions: 14925
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 425
Number of HSP's successfully gapped in prelim test: 263
Number of HSP's that attempted gapping in prelim test: 5610
Number of HSP's gapped (non-prelim): 3911
length of query: 1119
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1006
effective length of database: 13,968,660
effective search space: 14052471960
effective search space used: 14052471960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.