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Search of human proteins with 40255133
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40255133 hypothetical protein LOC222256 [Homo sapiens]
(885 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40255133 hypothetical protein LOC222256 [Homo sapiens] 1779 0.0
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 149 1e-35
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 139 2e-32
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 130 4e-30
gi|203097724 cadherin-like 29 [Homo sapiens] 127 3e-29
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 124 3e-28
gi|11056063 protocadherin gamma subfamily A, 7 isoform 1 precurs... 124 5e-28
gi|14196477 protocadherin gamma subfamily A, 7 isoform 2 precurs... 124 5e-28
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 122 1e-27
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 122 1e-27
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 122 1e-27
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 122 1e-27
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 122 1e-27
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 122 1e-27
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 122 1e-27
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 122 1e-27
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 122 1e-27
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 122 1e-27
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 122 1e-27
gi|16933557 dachsous 1 precursor [Homo sapiens] 122 1e-27
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi... 120 4e-27
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 119 1e-26
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 119 1e-26
gi|9256614 protocadherin beta 3 precursor [Homo sapiens] 118 2e-26
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens] 118 2e-26
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 117 4e-26
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 115 1e-25
gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precur... 115 2e-25
gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precur... 115 2e-25
gi|14196455 protocadherin gamma subfamily A, 11 isoform 3 precur... 115 2e-25
>gi|40255133 hypothetical protein LOC222256 [Homo sapiens]
Length = 885
Score = 1779 bits (4609), Expect = 0.0
Identities = 885/885 (100%), Positives = 885/885 (100%)
Query: 1 MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP 60
MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP
Sbjct: 1 MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP 60
Query: 61 QIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT 120
QIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT
Sbjct: 61 QIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT 120
Query: 121 VQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS 180
VQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS
Sbjct: 121 VQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS 180
Query: 181 FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPT 240
FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPT
Sbjct: 181 FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPT 240
Query: 241 RVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDR 300
RVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDR
Sbjct: 241 RVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDR 300
Query: 301 DAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAK 360
DAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAK
Sbjct: 301 DAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAK 360
Query: 361 GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN 420
GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN
Sbjct: 361 GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN 420
Query: 421 LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV 480
LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV
Sbjct: 421 LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV 480
Query: 481 GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQ 540
GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQ
Sbjct: 481 GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQ 540
Query: 541 ATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR 600
ATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR
Sbjct: 541 ATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR 600
Query: 601 SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSD 660
SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSD
Sbjct: 601 SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSD 660
Query: 661 RKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGS 720
RKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGS
Sbjct: 661 RKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGS 720
Query: 721 ILLLGLLVYLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGE 780
ILLLGLLVYLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGE
Sbjct: 721 ILLLGLLVYLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGE 780
Query: 781 AIDPVTGETYEFNSKTGARKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEE 840
AIDPVTGETYEFNSKTGARKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEE
Sbjct: 781 AIDPVTGETYEFNSKTGARKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEE 840
Query: 841 DELSGKAWAEDAGLGSRNEGGKLGNPKNRNPAFMNRAYPKPHPGK 885
DELSGKAWAEDAGLGSRNEGGKLGNPKNRNPAFMNRAYPKPHPGK
Sbjct: 841 DELSGKAWAEDAGLGSRNEGGKLGNPKNRNPAFMNRAYPKPHPGK 885
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 149 bits (376), Expect = 1e-35
Identities = 148/526 (28%), Positives = 249/526 (47%), Gaps = 44/526 (8%)
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPG-FIYQVEAFDPEDTSRNIPLSYFLI 175
++ V+V D N+ P + L I E PG I Q+ A D D N ++Y L+
Sbjct: 3008 IVEVKVLDANDNSPVCEKTLYSDT---IPEDVLPGKLIMQISATDA-DIRSNAEITYTLL 3063
Query: 176 -SPPKSFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEV 233
S + F+++ + G L ++T LD E +HL+V D GG + + + ++ND
Sbjct: 3064 GSGAEKFKLNPDTGELKTSTPLDREE-QAVYHLLVRATDGGGRFCQASIVLTLEDVNDNA 3122
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYS-ITTVSKYFMINQLTGTI 292
P F++ TV E PGT++ + A D D G +LYS I + F IN+L+G I
Sbjct: 3123 PEFSADPYAITVFENTEPGTLLTRVQATDA-DAGLNRKILYSLIDSADGQFSINELSGII 3181
Query: 293 QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352
Q+ + +DR EL+ T+SL+ + + P I ++ D+NDNP + +
Sbjct: 3182 QLEKPLDR---ELQAVYTLSLKAVDQGLPRRLTATGTVIVSVL-DINDNPPVFEYREYGA 3237
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412
V E GT +L + + D EA N +++ SG G +F D + +G + +I +
Sbjct: 3238 TVSEDILVGTEVLQV--YAASRDIEA-NAEITYSIISGNEHG-KFSID-SKTGAVFIIEN 3292
Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472
LDYE + ++Y + ++ D P + V + + N+ +F + +Y +SE
Sbjct: 3293 LDYE------SSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISE 3346
Query: 473 RRPARTRVGQVRATDKDLPQSS-LLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531
V V A D D P +S + YSI G + F I+P GE+++ +D ET
Sbjct: 3347 DAVLEQSVITVMADDADGPSNSHIHYSIIDGNQG----SSFTIDPVRGEVKVTKLLDRET 3402
Query: 532 TPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF 588
Y L +QA++N ++ TV +++ + ND P+ + +Y + + + VG ++
Sbjct: 3403 ISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSV--L 3460
Query: 589 KLTCTDLDSSPRS--FRYSIGPGNVNNHFTFSPNAGSNVTRLLLTS 632
+L TD DSS F ++I GN F +P +LLTS
Sbjct: 3461 QLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQG------VLLTS 3500
Score = 117 bits (293), Expect = 5e-26
Identities = 144/606 (23%), Positives = 255/606 (42%), Gaps = 67/606 (11%)
Query: 89 MEQLDFETGPNIFDLQIYVKDE---VGVTDLQVLTVQVTDVNE---PPQFQGNLAEGLHL 142
++QLDFE +++L + KD+ V ++ + V+V DVNE PP F + +G
Sbjct: 986 VQQLDFEK-KQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGT-- 1042
Query: 143 YIVERANPGFIYQVEAFDPEDTSRNIPLSYFLI--SPPKSFRMSAN-GTLFSTTELDFEA 199
+ E A G + + ED R+ + Y + S F++ G + ++ LD E+
Sbjct: 1043 -VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
Query: 200 GHRSFHLIVEVRDSGGLKAST--ELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVAN 257
+ L V D G + S+ E+ + + ++ND P+ + P ++E V
Sbjct: 1102 TSH-YWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQ 1160
Query: 258 ITAEDPDDEGFPSHLLYSITTVSK--YFMINQLTGTIQVAQR-IDRDAGELRQNPTISLE 314
I A DPD L+Y IT+ + +F I+ TG I R +DR+ Q LE
Sbjct: 1161 IEAFDPDSSS-NDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDRE-----QQDEHILE 1214
Query: 315 VLVKDRPYGGQENRIQITFIVEDVNDN-PATCQKFTFSIMVPERTA----KGTLLLDLNK 369
V V D + ++ + D NDN P QKF + I +PER + L
Sbjct: 1215 VTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKF-YKIRLPEREKPDRERNARREPLYH 1273
Query: 370 FCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTV 429
D E PN ++++ G G F++ G + +A +Y +
Sbjct: 1274 VIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG-----------VVSSKRFSAAGEYDI 1322
Query: 430 I-IQVQDVAPPYYKNNVYVYI--LTSPENEF-PLIFDRPSYVFDVSERRPARTRVGQVRA 485
+ I+ D P + ++I ++ P+ P+ F+ + F V E P +G +
Sbjct: 1323 LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV 1382
Query: 486 TDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNE 545
+P L+ TGG Y + F ++ TG + + +D E Y L ++AT+
Sbjct: 1383 EPPGIP----LWFDITGG---NYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGT 1435
Query: 546 DTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR---SF 602
T V + +++ ND +P + + Y + +P D T I +++ D D + +
Sbjct: 1436 TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEI--LQISAVDQDEKNKLIYTL 1493
Query: 603 RYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRK 662
+ S P ++ F P GS L + + D+ + + + L V V D ++ R
Sbjct: 1494 QSSRDPLSLKK-FRLDPATGS----LYTSEKLDH----EAVHQHTLTVMVRDQDVPVKRN 1544
Query: 663 KAEALV 668
A +V
Sbjct: 1545 FARIVV 1550
Score = 115 bits (287), Expect = 2e-25
Identities = 130/543 (23%), Positives = 225/543 (41%), Gaps = 38/543 (6%)
Query: 57 PGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDL 116
P F I+N + F+++ SG V++T D E FD+ + V +E + +
Sbjct: 2011 PLFYHILNPD---RRFKISRTSG----VLSTTGTPFDREQ-QEAFDVVVEVTEEHKPSAV 2062
Query: 117 QVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANP--GFIYQVEAFDPEDTSRNIPLSYFL 174
+ V+V + E + L Y V + + G + + D+ RN + Y+L
Sbjct: 2063 AHVVVKV--IVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYL 2120
Query: 175 ISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVP 234
+ F++ G + + + + ++ + + V +D G S E+ V I +N +P
Sbjct: 2121 KEHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMP 2180
Query: 235 RFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FMINQLTGTI 292
F P + E + + V ++ A P EG + YSIT + F IN TG I
Sbjct: 2181 VFEKPFYSAEIAESIQVHSPVVHVQANSP--EGL--KVFYSITDGDPFSQFTINFNTGVI 2236
Query: 293 QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352
V +D +A +P L + D G + + IV+D+NDNP + ++++
Sbjct: 2237 NVIAPLDFEA-----HPAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAV 2290
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412
+ E + GT ++ + D DSE PN ++ M + +G I L+
Sbjct: 2291 TLSEASVIGTSVVQVR--ATDSDSE-PNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRT 2347
Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472
LDYE ++T+ ++ D P ++V V + + N+ P +F++ Y +SE
Sbjct: 2348 LDYEQ------SRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401
Query: 473 RRPARTRVGQVRATDKDLPQ-SSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531
P V V+A D D L YSI +G F I+ TG + L
Sbjct: 2402 HAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKH----FVIDSATGIITLSNLHRHAL 2457
Query: 532 TPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLT 591
P Y L + ++ SS V V ++ N P N Y + L + + T + K T
Sbjct: 2458 KPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTT 2517
Query: 592 CTD 594
D
Sbjct: 2518 DGD 2520
Score = 113 bits (282), Expect = 9e-25
Identities = 115/456 (25%), Positives = 204/456 (44%), Gaps = 41/456 (8%)
Query: 187 GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVL 246
GT+ LD E +++L VE D G T++ + +++ ND P+F++ +
Sbjct: 1409 GTIIVAKPLDAEQ-KSNYNLTVEATD-GTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIP 1466
Query: 247 EELSPGTIVANITAEDPDDEGFPSHLLYSITTVS-----KYFMINQLTGTIQVAQRIDRD 301
E+ +P T + I+A D D++ + L+Y++ + K F ++ TG++ ++++D +
Sbjct: 1467 EDTAPETEILQISAVDQDEK---NKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHE 1523
Query: 302 AGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361
A + Q+ +L V+V+D+ + N +I V D ND+ ++ V E A G
Sbjct: 1524 A--VHQH---TLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVG 1578
Query: 362 TLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNL 421
+++L + D + N +++ SG G+ F+ DP G I +LD N +
Sbjct: 1579 SVVLQVTAL---DKDKGKNAEVLYSIESG-NIGNSFMIDPV-LGSIKTAKELDRSNQA-- 1631
Query: 422 AAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVG 481
+Y ++++ D P V I + + F Y ++SE + VG
Sbjct: 1632 ----EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVG 1687
Query: 482 QVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA 541
V A QSS++Y I G + F INP +G + +D ET PIY L IQ
Sbjct: 1688 MVTAHS----QSSVVYEIKDGNTG----DAFDINPHSGTIITQKALDFETLPIYTLIIQG 1739
Query: 542 TNNEDTS-SVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI---QNFKLTCTDLDS 597
TN S + TV V++ +END P+ Y + + + + +N L D+
Sbjct: 1740 TNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADA 1799
Query: 598 SPRS---FRYSIGPGNVNNHFTFSPNAGSNVTRLLL 630
S Y I +V+ +F + G+ T L L
Sbjct: 1800 DKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSL 1835
Score = 100 bits (250), Expect = 5e-21
Identities = 110/437 (25%), Positives = 186/437 (42%), Gaps = 40/437 (9%)
Query: 163 DTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEAGHRSFHLIVEVRDSG--GLK 217
D N ++Y +IS + + S + G +F LD+E+ H ++L VE D G L
Sbjct: 3258 DIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHE-YYLTVEATDGGTPSLS 3316
Query: 218 ASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSIT 277
+ VN+ ++ND P F+ T + E+ V + A+D D SH+ YSI
Sbjct: 3317 DVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPS-NSHIHYSII 3375
Query: 278 TVSK--YFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFI- 334
++ F I+ + G ++V + +DR+ TIS L G R+ T +
Sbjct: 3376 DGNQGSSFTIDPVRGEVKVTKLLDRE--------TISGYTLTVQASDNGSPPRVNTTTVN 3427
Query: 335 --VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVG 392
V DVNDN + +S+++ E G +L L D+DS F FT+ +G
Sbjct: 3428 IDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQL--VVTDEDSSHNGPPFFFTIVTG-N 3484
Query: 393 SGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTS 452
F +P G VL+ + + Y + ++V D P + Y+ I
Sbjct: 3485 DEKAFEVNPQG----VLLTSSAIKRKEK----DHYLLQVKVADNGKPQLSSLTYIDIRVI 3536
Query: 453 PENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVF 512
E+ +P S + +G++ ATD+D+ +L YS+ Q N+F
Sbjct: 3537 EESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQDV-YDTLTYSLDP-----QMDNLF 3590
Query: 513 WINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYF 572
++ G+L K+D Y+L + T+ + T+ +TV+I + E T F
Sbjct: 3591 SVSSTGGKLIAHKKLDIGQ---YLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTIAIRF 3647
Query: 573 LALPVDLKVGTNIQNFK 589
L + VG +NF+
Sbjct: 3648 ANLTPEEFVGDYWRNFQ 3664
Score = 87.4 bits (215), Expect = 5e-17
Identities = 136/568 (23%), Positives = 231/568 (40%), Gaps = 80/568 (14%)
Query: 119 LTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGF----------IYQVE--AFDPEDTS- 165
LT+Q D PPQF + ++ +P F +Y+ E F P +T
Sbjct: 334 LTLQAKDKGTPPQFSS-------VKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPV 386
Query: 166 ---RNIP----LSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKA 218
+ IP L Y S P + S N + L+ ++ H +EV S KA
Sbjct: 387 VMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS-DRKA 445
Query: 219 STELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITT 278
ST++ V ++ N P FT E + GT V +++A DP DEG ++ YSI
Sbjct: 446 STKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDP-DEGENGYVTYSIAN 504
Query: 279 VSKY-FMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVED 337
++ F I+ TG + ++ +D + + + T+ + PY +E + T + +
Sbjct: 505 LNHVPFAIDHFTGAVSTSENLDYEL--MPRVYTLRIRASDWGLPY-RREVEVLATITLNN 561
Query: 338 VNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDD------DSEAPN--NRFNFTMPS 389
+NDN +K +P G + ++ D+ EA N + F+ S
Sbjct: 562 LNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNS 621
Query: 390 GVGSGSRFLQDPAG------SGKIVLIGDLDYENPSNL---AAGNKYTVIIQVQD--VAP 438
GV S R L D G S +I ++ P + A + V +Q ++ VA
Sbjct: 622 GVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAK 681
Query: 439 PYYKNNVYVYILTSPENEFPLIFDRPSY-------------VFDVSERRPARTRVGQVRA 485
+ + L + + FD S V E +P + V + +
Sbjct: 682 MLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNS 741
Query: 486 TDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN- 543
TD D L+Y++S G + F I+ +TG L++++ +D ETT Y L I +
Sbjct: 742 TDLDTGFNGKLVYAVSGGNED----SCFMIDMETGMLKILSPLDRETTDKYTLNITVYDL 797
Query: 544 --NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS 601
+ + + V +++ ND P SYF+ + D +V + I ++ TD D P
Sbjct: 798 GIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEI--IQVEATDKDLGPNG 855
Query: 602 -FRYSIGPGNVNNHFTFSPNAGSNVTRL 628
YSI V + TFS ++ + V +
Sbjct: 856 HVTYSI----VTDTDTFSIDSVTGVVNI 879
Score = 87.0 bits (214), Expect = 7e-17
Identities = 142/626 (22%), Positives = 245/626 (39%), Gaps = 74/626 (11%)
Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90
++E +PP T V + P + S P F +N+ +G + +
Sbjct: 376 ISEFAPPNTPV------VMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQ 429
Query: 91 QLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANP 150
Q F+L++ D T + V + + PP+F + V
Sbjct: 430 QAAH------FELEVTTSDRKASTKVLVKVLGAN--SNPPEFTQTAYKAAFDENVPIGTT 481
Query: 151 GFIYQVEAFDPEDTSRN-IPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
+ + A DP++ + S ++ G + ++ LD+E R + L +
Sbjct: 482 --VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIR 539
Query: 210 VRDSGGLKASTELQV----NIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDD 265
D GL E++V + NLND P F T+ +L G + ++A D D+
Sbjct: 540 ASD-WGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598
Query: 266 EGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQ 325
+ + + + +F +N +G + + + + G + SL + D
Sbjct: 599 LQLVQYQIEAGNELD-FFSLNPNSGVLSLKRSLMDGLGA--KVSFHSLRITATDGENFAT 655
Query: 326 ENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLL---DLNKFCFDDDS-EAPNN 381
I IT N C++ + M+ E+ + L ++ FD S A
Sbjct: 656 PLYINITVAASHKLVN-LQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIP 714
Query: 382 RFNFTMPSG--------VGSGSRFLQ----DPAGSGKIVLI----------------GDL 413
+F T+P+G VGS F+ D +GK+V G L
Sbjct: 715 QFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGML 774
Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473
+P + +KYT+ I V D+ P ++++ N+ P F + SY +VSE
Sbjct: 775 KILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSED 834
Query: 474 RPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532
+ + + QV ATDKDL P + YSI T + F I+ TG + + +D E
Sbjct: 835 KEVHSEIIQVEATDKDLGPNGHVTYSIVTD------TDTFSIDSVTGVVNIARPLDRELQ 888
Query: 533 PIYILRIQATNN-----EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQN 587
+ L+I+A + + S+V V V++ + ND P P +Y + + DL GT I
Sbjct: 889 HEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW 948
Query: 588 FKLTCTDLDSSPRSFRYSI---GPGN 610
+ DL S + RYS+ G GN
Sbjct: 949 LEAHDPDLGQSGQ-VRYSLLDHGEGN 973
Score = 83.2 bits (204), Expect = 1e-15
Identities = 139/626 (22%), Positives = 258/626 (41%), Gaps = 84/626 (13%)
Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLT------------EAFRVNWLS 78
+A+N+ P + ++SV+LS ++S I F +V ++ + +AF +N S
Sbjct: 1659 IADNASPKFTSKEYSVELSETVS--IGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHS 1716
Query: 79 GTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE------PPQF 132
GT ++T + LDFET P I+ L I + G++ + V + D N+ ++
Sbjct: 1717 GT---IIT--QKALDFETLP-IYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY 1770
Query: 133 QGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRM---SANGTL 189
G ++E + V + + A D + S N L Y ++ P S+ G +
Sbjct: 1771 TGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVEPSVHTYFAIDSSTGAI 1829
Query: 190 FSTTELDFEAGHRSFHLIVEVRDSGGLKASTE----LQVNIVNLNDEVPRFTSPTRVYTV 245
+ LD+E FH V+V D G + E + V+++++ND P F P ++
Sbjct: 1830 HTVLSLDYEETS-IFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASL 1888
Query: 246 LEELSPGTIVANITAEDPDDEGFPSHLLYSIT--TVSKYFMINQLTGTIQVAQRIDRDAG 303
L G V + A D D F S L+YSIT + + F ++ TG + V ++
Sbjct: 1889 LLPTYKGVKVITVNATDADSSAF-SQLIYSITEGNIGEKFSMDYKTGALTV-----QNTT 1942
Query: 304 ELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFT---FSIMVPERTAK 360
+LR L V D + G +T + +V ++ + KFT +S +V E + +
Sbjct: 1943 QLRSR--YELTVRASDGRFAG------LTSVKINVKESKESHLKFTQDVYSAVVKENSTE 1994
Query: 361 GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN 420
L + A N N + + + R + SG + G P +
Sbjct: 1995 AETLAVIT---------AIGNPINEPLFYHILNPDRRFKISRTSGVLSTTG-----TPFD 2040
Query: 421 LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV 480
+ V+++V + P +V V ++ +N+ +F Y V +
Sbjct: 2041 REQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVI 2100
Query: 481 GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET-TPIYILRI 539
V A D+D ++ ++ ++ F I P GE+ L + + +T Y++ +
Sbjct: 2101 RYVTAVDRDSGRNGEVHYYLK-----EHHEHFQIGP-LGEISLKKQFELDTLNKEYLVTV 2154
Query: 540 QATNNEDTS-SVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSS 598
A + + + S V V I N P+ Y + ++V + + + + +S
Sbjct: 2155 VAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQA------NS 2208
Query: 599 PRSFR--YSIGPGNVNNHFTFSPNAG 622
P + YSI G+ + FT + N G
Sbjct: 2209 PEGLKVFYSITDGDPFSQFTINFNTG 2234
Score = 81.6 bits (200), Expect = 3e-15
Identities = 123/558 (22%), Positives = 226/558 (40%), Gaps = 55/558 (9%)
Query: 89 MEQLDFET-GPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVE 146
+E+LD ET + +++ KD G + V +TD N+ PQF+ E + I
Sbjct: 2551 LEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYE---VNIGS 2607
Query: 147 RANPGF-IYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN----GTLFSTTELDFEAGH 201
A G + +V A D ++ S N ++Y + + +S + + + +T E +
Sbjct: 2608 SAAKGTSVVKVLASDADEGS-NADITYAIEADSESVKENLEINKLSGVITTKESLIGLEN 2666
Query: 202 RSFHLIVEVRDSGGLKASTELQVNIVNLNDEV--PRFTSPTRVYTVLEELSPGTIVANIT 259
F V D+G + + V + L E+ P+F+ P +TV E++ GT + I
Sbjct: 2667 EFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIR 2726
Query: 260 AEDPDDEGFPSHLLYSI-------TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTIS 312
AE +LYS+ + + F+I++ +G +++ + +D + + Q +I
Sbjct: 2727 AEHSGT------VLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQF-SIL 2779
Query: 313 LEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCF 372
D + ++ V+D NDN + + + E G+ ++ +
Sbjct: 2780 ARCTQDDHEMVAS---VDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRA--- 2833
Query: 373 DDDSEAPNNRFNFTMPSGVGSGSRFLQDPA---GSGKIVLIGDLDYENPSNLAAGNKYTV 429
D N + +++ ++ A +G I + +LD+E N Y +
Sbjct: 2834 SDADSGTNGQVMYSLDQS--QSVEVIESFAINMETGWITTLKELDHEKRDN------YQI 2885
Query: 430 IIQVQDVAPPYYKNNVYVYILTSPE-NEFPLIFDRPSYVFDVSERRPARTRVGQVRATDK 488
+ D ++ + +T + N+ P F Y VSE P + + TD
Sbjct: 2886 KVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDA 2945
Query: 489 DLPQSS--LLYSISTGGASLQYPNVFWINPKTGELQLVTK--VDCETTPIYILRIQATNN 544
D + + + Y I TGG L F + E ++ K +D E Y+L I AT+
Sbjct: 2946 DSEEINRQVTYFI-TGGDPL---GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG 3001
Query: 545 EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRY 604
+S V V +L+ ND P+C Y +P D+ G I T D+ S+
Sbjct: 3002 TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYT 3061
Query: 605 SIGPGNVNNHFTFSPNAG 622
+G G F +P+ G
Sbjct: 3062 LLGSG--AEKFKLNPDTG 3077
Score = 77.4 bits (189), Expect = 5e-14
Identities = 121/523 (23%), Positives = 223/523 (42%), Gaps = 59/523 (11%)
Query: 204 FHLIVEVRDSG-GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAED 262
+ LIV+ + ++A T+++V +++ ND P F+ + ++ E + T +A ++A D
Sbjct: 116 YTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATD 175
Query: 263 PDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRP- 321
D G YS + F I+ +G I + R+D + +E+L DR
Sbjct: 176 A-DIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLD-----YLETKLYEMEILAADRGM 229
Query: 322 --YG--GQENRIQITFIVEDVNDNPATCQKFTFSIMVPER-TAKGTLLLDLNKFCFDDDS 376
YG G + ++T +E N+ T S +R A + +D D D
Sbjct: 230 KLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTVD------DCDQ 283
Query: 377 EAPNNRFNFTMPSG-VGSGSRFLQDPAGSG--KIVLIGDLDYENPSNLAAGNKYTVIIQV 433
A + + ++ +G + R ++ GS K+ IG +D+++ Y + +Q
Sbjct: 284 GANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHP-----FGYNLTLQA 338
Query: 434 QDVAPPYYKNNVYVYILTSPE-NEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQ 492
+D P ++V V +TSP+ P+ F++ Y ++SE P T V V+A +P
Sbjct: 339 KDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA----IPA 394
Query: 493 SSLLYSI--STGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSV 550
S L + ST G + F +N TG + ++ V + + ++ T ++ +S
Sbjct: 395 YSHLRYVFKSTPGKA-----KFSLNYNTGLISILEPVKRQQAAHF--ELEVTTSDRKAST 447
Query: 551 TVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSF-RYSIGPG 609
V V +L N P T +Y A ++ +GT + + L+ D D + YSI
Sbjct: 448 KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS--LSAVDPDEGENGYVTYSI--A 503
Query: 610 NVN------NHFTFSPNAGSNVTRLLLTSRFDYA-----GGFDKIWDYKLLVYVTDDNLM 658
N+N +HFT + + N+ L+ + G + ++L +T +NL
Sbjct: 504 NLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLN 563
Query: 659 SDRKKAEALVETGTVTLSIKVIPHPTTI--ITTTPRPRVTYQV 699
+ E + GT+ + V TT+ I V YQ+
Sbjct: 564 DNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQI 606
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/189 (25%), Positives = 81/189 (42%), Gaps = 17/189 (8%)
Query: 458 PLIFDRPSYVFDVSERRPARTRVGQVRATDKDL--PQSSLLYSISTGGASLQYPNVFWIN 515
PL F Y V E A+T VG + P + Y I +G + + +I
Sbjct: 31 PLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL 90
Query: 516 PKTGELQLVTK------VDCETTPIYILRIQAT--NNEDTSSVTVTVNILEENDEKPICT 567
L++ TK ++ E Y L ++A N + V V +L+ ND +P+ +
Sbjct: 91 GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFS 150
Query: 568 PNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTR 627
P SY ++LP + + T+I T D+ ++ F YS + + F P +G
Sbjct: 151 PTSYSVSLPENTAIRTSIARVSATDADIGTN-GEFYYSF--KDRTDMFAIHPTSGV---- 203
Query: 628 LLLTSRFDY 636
++LT R DY
Sbjct: 204 IVLTGRLDY 212
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 139 bits (349), Expect = 2e-32
Identities = 148/549 (26%), Positives = 248/549 (45%), Gaps = 51/549 (9%)
Query: 92 LDFETGPNIFDLQIY-VKDEVGVTDLQVLTVQVT--DVNE-PPQFQGNLAEGLHLYIVER 147
LD E G ++ + +Y ++ Q V++T D+N+ PP F ++ L L + E
Sbjct: 1696 LDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDM---LDLTVEEN 1752
Query: 148 ANPGF-IYQVEAFDPEDTSRNIPLSYFLIS-PPKSFRMSA-NGTLFSTTELDFEAGHRSF 204
G I Q+ A D D N ++Y +IS SFR+ +G L +T LD E RS
Sbjct: 1753 IGDGSKIMQLTAMDA-DEGANALVTYTIISGADDSFRIDPESGDLIATRRLDRE--RRSK 1809
Query: 205 HLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPD 264
+ ++ D G + + + + ++ND P+F+ P + + E+ PG++VA I A D D
Sbjct: 1810 YSLLVRADDGLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATD-D 1868
Query: 265 DEGFPSHLLYSITTVSK--YFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPY 322
D G + Y + + F +N +TG + + +D E++Q ++ V+
Sbjct: 1869 DSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDY---EVQQYYILT----VRAEDG 1921
Query: 323 GGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNR 382
GGQ I++ F + DVNDNP ++S + E G+ +L N D + N++
Sbjct: 1922 GGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFN---VTDADDGINSQ 1978
Query: 383 FNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQD---VAPP 439
+++ SG G +F D +G + ++ LD E+ S Y +++QV D +
Sbjct: 1979 LTYSIASGDSLG-QFTVDK--NGVLKVLKALDRESQS------FYNLVVQVHDLPQIPAS 2029
Query: 440 YYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL-PQSSLLYS 498
+ + V I+ N+ P F P + + E P T V + +ATD D P S + Y+
Sbjct: 2030 RFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATDPDSGPNSYIEYT 2088
Query: 499 ISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNED---TSSVTVTVN 555
+ N F I GE++L ++D E Y L + AT+ +SS V V
Sbjct: 2089 LLN-----PLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVM 2143
Query: 556 ILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR-SFRYSIGPGNVNNH 614
+L+ ND PI Y + + + GT+I ++ D D RY I GN N
Sbjct: 2144 VLDINDNNPIFAQALYKVEINENTLTGTDI--IQVFAADGDEGTNGQVRYGIVNGNTNQE 2201
Query: 615 FTFSPNAGS 623
F G+
Sbjct: 2202 FRIDSVTGA 2210
Score = 137 bits (345), Expect = 4e-32
Identities = 163/623 (26%), Positives = 265/623 (42%), Gaps = 67/623 (10%)
Query: 30 NVAENSPPGTSV-----HKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEV 84
++ EN P GTSV H ++ LS I + P F ++ + GT +
Sbjct: 1428 SIVENIPIGTSVISVTAHDPDADINGQLSYTI------IQQMPRGNHFTIDEVKGTIYTN 1481
Query: 85 VTTGMEQLDFETGPNIFDLQIYVKDEVGVTD-----LQVLTVQVTDVNEP-PQF--QGNL 136
++D E N+F+L + D+ + L+ +T+ VTD+N+ P F Q L
Sbjct: 1482 A-----EIDREFA-NLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNAL 1535
Query: 137 AEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS-PPKSFRMSA-NGTLFSTTE 194
A I + + A DP D N + Y +I+ +F + +G L +
Sbjct: 1536 AADPSAVI-----GSVLTTIMAADP-DEGANGEIEYEIINGDTDTFIVDRYSGDLRVASA 1589
Query: 195 LDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSP-GT 253
L ++LIV D G + + ++ I+ + P FT P + T+L+E P GT
Sbjct: 1590 L--VPSQLIYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQP-KYITILKEGEPIGT 1646
Query: 254 IVANITAEDPDDEGFP-SHLLYSI----TTVSKYFMINQLTGTIQVAQRIDRDAGELRQN 308
V +I A P P + + S+ TV + F I + TG IQ A +DR+ G
Sbjct: 1647 NVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLY- 1705
Query: 309 PTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLN 368
+ + + K + + R ++ ++D+NDNP + V E G+ ++ L
Sbjct: 1706 -LVDVYAIEKSTAF-PRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLT 1763
Query: 369 KFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYT 428
D E N +T+ SG R DP SG ++ LD E S KY+
Sbjct: 1764 AM---DADEGANALVTYTIISGADDSFRI--DPE-SGDLIATRRLDRERRS------KYS 1811
Query: 429 VIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDK 488
++++ D +++ + I S N+ F RP Y FD+ E + V + ATD
Sbjct: 1812 LLVRADD---GLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDD 1868
Query: 489 DL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN-NED 546
D + Y ++ +F++NP TG L +D E YIL ++A +
Sbjct: 1869 DSGVNGEITYIVNEDDED----GIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQ 1924
Query: 547 TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSI 606
+++ V NIL+ ND PI + NSY +L +L VG+ + F +T D D YSI
Sbjct: 1925 FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDAD-DGINSQLTYSI 1983
Query: 607 GPGNVNNHFTFSPNAGSNVTRLL 629
G+ FT N V + L
Sbjct: 1984 ASGDSLGQFTVDKNGVLKVLKAL 2006
Score = 129 bits (324), Expect = 1e-29
Identities = 152/617 (24%), Positives = 255/617 (41%), Gaps = 50/617 (8%)
Query: 69 TEAFRVNWLSGTYFEVVTTGMEQLDFETGPNI----FDLQIYVKDEVGVTDLQVLTVQVT 124
+E FR+N +G F + + + NI F + + + + +T+ +
Sbjct: 2915 SEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIV 2974
Query: 125 DVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLISPPK--S 180
D N+ PQF L + + G + +V A D +D N + YF+ +
Sbjct: 2975 DSNDNAPQF---LKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGK 3031
Query: 181 FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDEVPRFTS 238
F++ + S +++F + V +D G L + + + + N P F+
Sbjct: 3032 FKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQ 3091
Query: 239 PTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSK--YFMINQLTGTIQVAQ 296
T+ E S G+IV ++A D D + YSI++ ++ F IN TG + +A+
Sbjct: 3092 SHMSATIPESHSIGSIVRTVSARDRD-AAMNGLIKYSISSGNEEGIFAINSSTGILTLAK 3150
Query: 297 RIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPE 356
+D EL Q +++ + D + + +T V DVNDN + V E
Sbjct: 3151 ALDY---ELCQKHEMTISAI--DGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLE 3205
Query: 357 RTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYE 416
GT ++ LN D N +T+ S F+ DP +G I G LD+E
Sbjct: 3206 NAPSGTTVIHLNA---TDADSGTNAVIAYTVQSS--DSDLFVIDP-NTGVITTQGFLDFE 3259
Query: 417 NPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPA 476
+ Y + ++ +V + V I NE+ F Y F++SE P
Sbjct: 3260 TKQS------YHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPK 3313
Query: 477 RTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYI 536
T VG+V A+D+DL ++ + G + + F IN KTG++ + +D E
Sbjct: 3314 GTIVGEVFASDRDLGTDGEVHYLIFGNSRKKG---FQINKKTGQIYVSGILDREKEERVS 3370
Query: 537 LRIQATN-----NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLT 591
L++ A N D VTV V +L+ ND PI T N Y + + + +GT++
Sbjct: 3371 LKVLAKNFGSIRGADIDEVTVNVTVLDANDP-PIFTLNIYSVQISEGVPIGTHVTFVSAF 3429
Query: 592 CTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVY 651
+D S F Y IG GN N F+ +P G ++ +T+ D + + Y L V
Sbjct: 3430 DSDSIPSWSRFSYFIGSGNENGAFSINPQTG----QITVTAELDR----ETLPIYNLSVL 3481
Query: 652 VTDDNLMSDRKKAEALV 668
D S A LV
Sbjct: 3482 AVDSGTPSATGSASLLV 3498
Score = 119 bits (297), Expect = 2e-26
Identities = 147/602 (24%), Positives = 249/602 (41%), Gaps = 49/602 (8%)
Query: 48 LSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYV 107
+SAS + ++ + F +N ++G E+ F + L++
Sbjct: 815 VSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSF------YQLKVVA 868
Query: 108 KDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSR 166
VT ++ + V D+N+ E ++ +VE G I+Q +A DP++
Sbjct: 869 SGGT-VTGDTMVNITVKDLNDNSPHFLQAIESVN--VVENWQAGHSIFQAKAVDPDEGVN 925
Query: 167 NIPLSYFLISPPKSFRMSA-NGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVN 225
+ L +P F ++ NGT+ LD AG ++ L +S L V
Sbjct: 926 GMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHAGSYQIEILASDMGVPQLSSSVILTVY 985
Query: 226 IVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSIT--TVSKYF 283
+ ++ND P F + T+ E + + A D D G + Y+I F
Sbjct: 986 VHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDS-GANGEIAYTIAEGNTGDAF 1044
Query: 284 MINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPA 343
I G + + +DR+ + L V+ DR + +T I+EDVNDN
Sbjct: 1045 GIFP-DGQLYIKSELDRELQD-----RYVLMVVASDRAVEPLSATVNVTVILEDVNDNRP 1098
Query: 344 TCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNN--RFNFTMPSGVGSGSRFLQDP 401
++ E G+ + K D PN R++F M +
Sbjct: 1099 LFNSTNYTFYFEEEQRAGSFV---GKVSAVDKDFGPNGEVRYSFEMVQPD------FELH 1149
Query: 402 AGSGKIVLIGDLDYENPSNL--AAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPL 459
A SG+I D E+ A +TVI Q + P K+ V++ N+
Sbjct: 1150 AISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPL-KDQATVHVYMKDINDNAP 1208
Query: 460 IFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKT 518
F + Y +SE T+V +V A+D D + L+ YSI G Q F I+ +
Sbjct: 1209 KFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQ----FAIDSTS 1264
Query: 519 GELQLVTKVDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLAL 575
G++ L+ K+D E TP Y L IQA ++ S+ T+ ++IL+END P ++ F+ +
Sbjct: 1265 GQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDV 1324
Query: 576 PVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRF 634
++++G + + +T TD DS + YSI N + F+ SPN GS + L +
Sbjct: 1325 LENMRIGELVSS--VTATDSDSGDNADLYYSITGTNNHGTFSISPNTGS----IFLAKKL 1378
Query: 635 DY 636
D+
Sbjct: 1379 DF 1380
Score = 112 bits (281), Expect = 1e-24
Identities = 152/611 (24%), Positives = 251/611 (41%), Gaps = 64/611 (10%)
Query: 79 GTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT--DVNEPPQFQGNL 136
G + +V+ G LD E P + L + V+D+ L V VT D+N+ P G+
Sbjct: 197 GAFLHLVSKG--GLDREVTPQ-YQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGS- 252
Query: 137 AEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTE- 194
+ E A G + QV A D D N + Y L F+M L + E
Sbjct: 253 -SHYQAGVPEDAVVGSSVLQVAAADA-DEGTNADIRYRLQDEGTPFQMDPETGLITVREP 310
Query: 195 LDFEAGHRSFHLIVEVRDSG--GLKASTELQVNIVNLNDEVP-----RFTSPTRVYTVLE 247
LDFEA R + L V+ D G L E + ++++ND P F + +R +V E
Sbjct: 311 LDFEA-RRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDE 369
Query: 248 ELSPGTIVANITAEDPDDEGFPSHLLYSIT--TVSKYFMINQLT----GTIQVAQRIDRD 301
GT+VA +T D D ++ I ++F + I+VA +DR+
Sbjct: 370 NAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRE 429
Query: 302 AGELRQNPTISLEVLVKDRPYGG--------QENRIQITFIVEDVNDNPATCQKFTFSIM 353
+ P+ +L V V D YG + + + V D+ND+P + + +
Sbjct: 430 -----RIPSYNLTVSVSDN-YGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVN 483
Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413
+ E G+ + ++ D N +++ SG G G + + +G G L
Sbjct: 484 LSEEAPPGSYVSGISA---TDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGL 540
Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473
D E S + + + Q V P + V +L +E P+ Y V E
Sbjct: 541 DRELASQIVLN----ISARDQGVHPKVSYAQLVVTLL-DVNDEKPVFSQPEGYDVSVVEN 595
Query: 474 RPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532
P T + +RATD DL + + +S+ + F ++P +G L ++ +D E
Sbjct: 596 APTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRS---FRLDPVSGRLSTISSLDREEQ 652
Query: 533 PIYILRIQATN---NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK 589
Y L + AT+ +S + V++L+ ND P+ P YF + + G+ I
Sbjct: 653 AFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVS 712
Query: 590 LTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLL 649
T DL ++ + +YSI G+ + F + +G TR+ L A Y+L
Sbjct: 713 ATDPDLGTN-GTVKYSISAGD-RSRFQVNAQSGVISTRMALDREEKTA--------YQLQ 762
Query: 650 VYVTD-DNLMS 659
+ TD NL S
Sbjct: 763 IVATDGGNLQS 773
Score = 112 bits (280), Expect = 2e-24
Identities = 157/624 (25%), Positives = 259/624 (41%), Gaps = 78/624 (12%)
Query: 62 IVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGV--TDLQVL 119
IVN N E FR++ ++G T + LD E P + L + D TD +
Sbjct: 2193 IVNGNTNQE-FRIDSVTGAI-----TVAKPLDREKTPT-YHLTVQATDRGSTPRTDTSTV 2245
Query: 120 TVQVTDVN------EPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYF 173
++ + D+N E + N+ E L P I QV A D +D N LSY
Sbjct: 2246 SIVLLDINDFVPVFELSPYSVNVPENLGTL------PRTILQVVARD-DDRGSNSKLSYV 2298
Query: 174 LI--SPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNL 229
L + +F +SA+G L T LD E R F L++ DSG L + + V + ++
Sbjct: 2299 LFGGNEDNAFTLSASGELGVTQSLDRETKER-FVLMITATDSGSPALTGTGTINVIVDDV 2357
Query: 230 NDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLT 289
ND VP F S T+ E+ GT V + A D D + + I + F IN T
Sbjct: 2358 NDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADAS---KNAVIRIIGGNSQFTINPST 2414
Query: 290 GTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQE---NRIQITFIVEDVNDNPATCQ 346
G I + +DR E + N T L V+ D G E + + V DVNDNP Q
Sbjct: 2415 GQIITSALLDR---ETKDNYT--LVVVCSDA--GSPEPLSSSTSVLVTVTDVNDNPPRFQ 2467
Query: 347 KFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGK 406
+ +P T G+ + + D PN+ ++++ SG S +F DP G
Sbjct: 2468 HHPYVTHIPSPTLPGSFVFAVT---VTDADIGPNSELHYSL-SGRNS-EKFHIDPL-RGA 2521
Query: 407 IVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSY 466
I+ G L+ ++ T + V+D ++ V + + +FP + +
Sbjct: 2522 IMAAGPLN--------GASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAK-EQ 2572
Query: 467 VFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTK 526
F E +P + V + T L + Y I++G N F I+ TG++ +
Sbjct: 2573 TFMFPENQPVSSLVTTI--TGSSLRGEPMSYYIASGNLG----NTFQIDQLTGQVSISQP 2626
Query: 527 VDCETTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGT 583
+D E Y++ I+A + +S + + +L+ ND PI + + + +L +
Sbjct: 2627 LDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENL---S 2683
Query: 584 NIQNFKLTCTDLDSSPR-SFRYSIGPGNVNNHFTFSPNAG----------SNVTRLLLTS 632
+ ++ D DS P Y I GN+ N F+ + G V+ +LT
Sbjct: 2684 PRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTI 2743
Query: 633 RFDYAGGFDKIWDYKLLVYVTDDN 656
+ G + K+++ + D+N
Sbjct: 2744 KSSDKGSPSQSTSVKVMINILDEN 2767
Score = 111 bits (277), Expect = 3e-24
Identities = 172/668 (25%), Positives = 280/668 (41%), Gaps = 88/668 (13%)
Query: 31 VAENSPPGTSVHKFSVK-LSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGM 89
+ E++P GT V + AS + VI +I+ N F +N +G +++T+ +
Sbjct: 2373 IPEDAPTGTDVLLVNASDADASKNAVI----RIIGGN---SQFTINPSTG---QIITSAL 2422
Query: 90 EQLDFETGPNIFDLQIYVKDEVGVTDLQVLT---VQVTDVNE-PPQFQGNLAEGLHLYIV 145
LD ET N + L + D L T V VTDVN+ PP+FQ H Y+
Sbjct: 2423 --LDRETKDN-YTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQH------HPYVT 2473
Query: 146 ERANP----GFIYQVEAFDPEDTSRNIPLSY---------FLISPPKSFRMSANGTLFST 192
+P F++ V D D N L Y F I P + M+A G L
Sbjct: 2474 HIPSPTLPGSFVFAVTVTDA-DIGPNSELHYSLSGRNSEKFHIDPLRGAIMAA-GPLNGA 2531
Query: 193 TELDFEAGHRSFHLIVEVRDSGGLKA--STELQVNIVNLNDEVPRFTSPTRVYTVLEELS 250
+E+ F V V+D G ST + V VN D P+ + + + E
Sbjct: 2532 SEVTFS---------VHVKDGGSFPKTDSTTVTVRFVNKAD-FPKVRAKEQTFMFPENQP 2581
Query: 251 PGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPT 310
++V IT G P + + F I+QLTG + ++Q +D E Q
Sbjct: 2582 VSSLVTTITGSSL--RGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDF---EKIQKYV 2636
Query: 311 ISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKF 370
+ +E P ++ IT + DVNDN ++ F + E + +L
Sbjct: 2637 VWIEARDGGFPPFSSYEKLDITVL--DVNDNAPIFKEDPFISEILENLSPRKIL---TVS 2691
Query: 371 CFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVI 430
D DS PN + ++ + +G S + +G+I + LD E S+ Y +
Sbjct: 2692 AMDKDS-GPNGQLDYEIVNGNMENSFSINH--ATGEIRSVRPLDREKVSH------YVLT 2742
Query: 431 IQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL 490
I+ D P +V V I EN+ F + + V E P V +V +D+D+
Sbjct: 2743 IKSSDKGSPSQSTSVKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDI 2801
Query: 491 PQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSS 549
+++ YSI ASL F INP TG++ + ++ E T Y +R+ A ++ T S
Sbjct: 2802 GINAISRYSIMD--ASLP----FTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVS 2855
Query: 550 VTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPG 609
VT+ + + ND P + SY+L P ++G+ + T D S+ + F +
Sbjct: 2856 TDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFI---K 2912
Query: 610 NVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE 669
+ + +F + G + +L ++ GF + + VT SDR K + E
Sbjct: 2913 SQSEYFRINATTGEIFNKQIL--KYQNVTGFSNVNINRHSFIVTS----SDRGKPSLISE 2966
Query: 670 TGTVTLSI 677
T TVT++I
Sbjct: 2967 T-TVTINI 2973
Score = 105 bits (262), Expect = 2e-22
Identities = 122/505 (24%), Positives = 218/505 (43%), Gaps = 59/505 (11%)
Query: 119 LTVQVTDVNE------PPQFQGNLAEGLHLYIVERANPG--FIYQVEAFDPEDTSRNIPL 170
+ V + D+N+ P Q+ ++ E PG +I V A DP D N +
Sbjct: 675 INVSLLDINDNSPVFYPVQYFAHIKEN---------EPGGSYITTVSATDP-DLGTNGTV 724
Query: 171 SYFLISPPKS-FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTE--LQVNIV 227
Y + + +S F+++A + ST ++ L + D G L++ + + + ++
Sbjct: 725 KYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVL 784
Query: 228 NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSK--YFMI 285
+ D P F+ + V E ++ G V +++A D S++ Y ITT + F I
Sbjct: 785 DTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMD---LNSNISYLITTGDQKGMFAI 841
Query: 286 NQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATC 345
NQ+TG + A IDR+ Q L+V+ G + + IT V+D+NDN
Sbjct: 842 NQVTGQLTTANVIDREEQSFYQ-----LKVVASGGTVTG-DTMVNIT--VKDLNDNSPHF 893
Query: 346 QKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSG 405
+ S+ V E G + D E N +++ + +G
Sbjct: 894 LQAIESVNVVENWQAGHSIFQAKAV---DPDEGVNGMVLYSLKQ---NPKNLFAINEKNG 947
Query: 406 KIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPS 465
I L+G LD S Y + I D+ P ++V + + N+ +FD+ S
Sbjct: 948 TISLLGPLDVHAGS-------YQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLS 1000
Query: 466 YVFDVSERRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLV 524
Y +SE P +R +V+A+DKD + Y+I+ G + F I P G+L +
Sbjct: 1001 YEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTG----DAFGIFP-DGQLYIK 1055
Query: 525 TKVDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKV 581
+++D E Y+L + A++ +++V VTV + + ND +P+ +Y + +
Sbjct: 1056 SELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRA 1115
Query: 582 GTNIQNFKLTCTDLDSSPR-SFRYS 605
G+ + K++ D D P RYS
Sbjct: 1116 GSFVG--KVSAVDKDFGPNGEVRYS 1138
Score = 95.5 bits (236), Expect = 2e-19
Identities = 122/533 (22%), Positives = 231/533 (43%), Gaps = 49/533 (9%)
Query: 72 FRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDE---VGVTDLQVLTVQVTDVNE 128
F ++ +SG E L G +F + D+ + D + V + D+N+
Sbjct: 1146 FELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDIND 1205
Query: 129 -PPQFQGNLAEGLHLYIVERA-NPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN 186
P+F L + I E A N + +V A D ++ + + + Y +I + + + +
Sbjct: 1206 NAPKF---LKDFYQATISESAANLTQVLRVSASDVDEGNNGL-IHYSIIKGNEERQFAID 1261
Query: 187 GTLFSTT---ELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDEVPRFTSPTR 241
T T +LD+EA ++ L+++ DSG L ++ L ++I++ ND P F T
Sbjct: 1262 STSGQVTLIGKLDYEATP-AYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTL 1320
Query: 242 VYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FMINQLTGTIQVAQRID 299
VLE + G +V+++TA D D G + L YSIT + + F I+ TG+I +A+++D
Sbjct: 1321 FVDVLENMRIGELVSSVTATD-SDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLD 1379
Query: 300 RDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTA 359
+ L L + KD+ + + + + V D NDNP + + E
Sbjct: 1380 FETQSL-----YKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIP 1434
Query: 360 KGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPS 419
GT ++ + D D++ N + ++T+ + G+ F D G I ++D E
Sbjct: 1435 IGTSVISVT--AHDPDADI-NGQLSYTIIQQMPRGNHFTIDEV-KGTIYTNAEIDRE--- 1487
Query: 420 NLAAGNKYTVIIQVQDVAPP-----YYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERR 474
N + + ++ D A P Y NV + ++T + P+ + + D S
Sbjct: 1488 ---FANLFELTVKANDQAVPIETRRYALKNVTI-LVTDLNDNVPMFISQNALAADPS--A 1541
Query: 475 PARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTP 533
+ + + A D D + Y I G + F ++ +G+L++ + + +
Sbjct: 1542 VIGSVLTTIMAADPDEGANGEIEYEIINGDT-----DTFIVDRYSGDLRVASAL-VPSQL 1595
Query: 534 IYILRIQATN-NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI 585
IY L + AT+ + T + I+ + + P+ T Y L +GTN+
Sbjct: 1596 IYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNV 1648
Score = 94.0 bits (232), Expect = 6e-19
Identities = 122/483 (25%), Positives = 201/483 (41%), Gaps = 43/483 (8%)
Query: 119 LTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176
+T+ VTD+N+ P+F +L E G + QV A DP++ S N + YF+ S
Sbjct: 2858 VTIFVTDINDNAPRFSRT---SYYLDCPELTEIGSKVTQVFATDPDEGS-NGQVFYFIKS 2913
Query: 177 PPKSFRMSAN-GTLFSTTELDFE---------AGHRSFHLIVEVRDSGGLKASTELQVNI 226
+ FR++A G +F+ L ++ SF + R L + T + +NI
Sbjct: 2914 QSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINI 2973
Query: 227 VNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FM 284
V+ ND P+F V + + GT + +TA D D G S + Y I+ + F
Sbjct: 2974 VDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFK 3033
Query: 285 INQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPAT 344
++ TG I VA + D L QN I++ K P + + IT + E+ P
Sbjct: 3034 LDNDTGWISVASSLISD---LNQNFFITVTAKDKGNPPLSSQATVHIT-VTEENYHTPEF 3089
Query: 345 CQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGS 404
Q S +PE + G+++ ++ D A N +++ SG G + + +
Sbjct: 3090 SQSH-MSATIPESHSIGSIVRTVSA---RDRDAAMNGLIKYSISSGNEEGIFAIN--SST 3143
Query: 405 GKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP 464
G + L LDYE K+ + I D V + N+ +F
Sbjct: 3144 GILTLAKALDYE------LCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSD 3197
Query: 465 SYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQL 523
Y V E P+ T V + ATD D ++++ Y++ + + L F I+P TG +
Sbjct: 3198 DYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDL-----FVIDPNTGVITT 3252
Query: 524 VTKVDCETTPIYILRIQATN---NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLK 580
+D ET Y L ++A N E S TV + + N+ P Y+ +
Sbjct: 3253 QGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAP 3312
Query: 581 VGT 583
GT
Sbjct: 3313 KGT 3315
Score = 87.8 bits (216), Expect = 4e-17
Identities = 105/433 (24%), Positives = 177/433 (40%), Gaps = 50/433 (11%)
Query: 239 PTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRI 298
P +V+ VLEE PGT+V I GF Y ++ F IN TG + I
Sbjct: 45 PRQVFQVLEEQPPGTLVGTIQTR----PGF----TYRLSESHALFAINSSTGALYTTSTI 96
Query: 299 DRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERT 358
DR E + I+L VL Y ++ +V D+NDN + + E +
Sbjct: 97 DR---ESLPSDVINLVVLSSAPTY-----PTEVRVLVRDLNDNAPVFPDPSIVVTFKEDS 148
Query: 359 AKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQD----PAGSG---KIVLIG 411
+ G ++ D S ++R ++ + G +G RF D P+G G +V G
Sbjct: 149 SSGRQVILDTATDSDIGSNGVDHR-SYRIIRGNEAG-RFRLDITLNPSGEGAFLHLVSKG 206
Query: 412 DLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVS 471
LD E +Y ++++V+D P + + V + N+ P +F Y V
Sbjct: 207 GLDRE------VTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVP 260
Query: 472 ERRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCE 530
E + V QV A D D + + Y + G Q ++P+TG + + +D E
Sbjct: 261 EDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQ------MDPETGLITVREPLDFE 314
Query: 531 TTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPIC-----TPNSYFLALPVDLKVG 582
Y L +QA + T + +L+ ND P+ S + ++ + +VG
Sbjct: 315 ARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVG 374
Query: 583 TNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDK 642
T + +T D ++ + I GN HF + N++ + + S D ++
Sbjct: 375 TVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDR----ER 430
Query: 643 IWDYKLLVYVTDD 655
I Y L V V+D+
Sbjct: 431 IPSYNLTVSVSDN 443
Score = 84.0 bits (206), Expect = 6e-16
Identities = 110/465 (23%), Positives = 187/465 (40%), Gaps = 45/465 (9%)
Query: 184 SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVY 243
S+ G L++T+ +D E+ +V + S TE++V + +LND P F P+ V
Sbjct: 85 SSTGALYTTSTIDRESLPSDVINLVVL--SSAPTYPTEVRVLVRDLNDNAPVFPDPSIVV 142
Query: 244 TVLEELSPGTIVANITAEDPD-DEGFPSHLLYSITTVSK--YFMIN---QLTGTIQVAQR 297
T E+ S G V TA D D H Y I ++ F ++ +G
Sbjct: 143 TFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHL 202
Query: 298 IDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPER 357
+ + + P L V V+D+ + +Q+ V+D+NDNP + VPE
Sbjct: 203 VSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPED 262
Query: 358 TAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYEN 417
G+ +L + D E N + + G+ F DP +G I + LD+E
Sbjct: 263 AVVGSSVLQV---AAADADEGTNADIRYRLQD---EGTPFQMDPE-TGLITVREPLDFE- 314
Query: 418 PSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYI-LTSPENEFPLI----FDRPSYVFDVSE 472
A +Y++ +Q D P I L + P++ F S V E
Sbjct: 315 -----ARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDE 369
Query: 473 RRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWIN----PKTGELQLVTKVD 528
T V + TD D P ++ S+ G + Q F + P +++ + +D
Sbjct: 370 NAQVGTVVALLTVTDADSPAANGNISVQILGGNEQ--RHFEVQSSKVPNLSLIKVASALD 427
Query: 529 CETTPIYILRIQATNN----------EDTSSVTVTVNILEENDEKPICTPNSYFLALPVD 578
E P Y L + ++N +S ++ + + + ND P+ + Y + L +
Sbjct: 428 RERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEE 487
Query: 579 LKVGTNIQNFKLTCTDLDSS-PRSFRYSIGPGNVNNHFTFSPNAG 622
G+ + ++ TD DS + RYSI GN F S ++G
Sbjct: 488 APPGSYVSG--ISATDGDSGLNANLRYSIVSGNGLGWFHISEHSG 530
Score = 67.4 bits (163), Expect = 6e-11
Identities = 89/308 (28%), Positives = 137/308 (44%), Gaps = 37/308 (12%)
Query: 62 IVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKD--EVGVTDLQVL 119
++ N + F++N +G ++ +G+ LD E + L++ K+ + D+ +
Sbjct: 3336 LIFGNSRKKGFQINKKTG---QIYVSGI--LDREKEERV-SLKVLAKNFGSIRGADIDEV 3389
Query: 120 TVQVT--DVNEPPQFQGNLAEGLHLYIVERANPG-FIYQVEAFDPEDTSRNIPLSYFLIS 176
TV VT D N+PP F N+ + I E G + V AFD + SYF+ S
Sbjct: 3390 TVNVTVLDANDPPIFTLNIYS---VQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGS 3446
Query: 177 PPKSFRMSAN---GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKA--STELQVNIVNLND 231
++ S N G + T ELD E ++L V DSG A S L V + ++ND
Sbjct: 3447 GNENGAFSINPQTGQITVTAELDRET-LPIYNLSVLAVDSGTPSATGSASLLVTLEDIND 3505
Query: 232 EVPRFTSPTRVYTVLEELSPGTIVANITAEDPD---DEGFPSHLLYSITTVSKYFMINQL 288
P T V+E PGT+V + + DPD ++G ++ L S + YF ++
Sbjct: 3506 NGPMLTVSEG--EVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLS-T 3562
Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDR--PYGGQENRIQITFIVEDVNDNPATCQ 346
G + + IDR+ Q L V+ KD P + IT I D NDNP+ Q
Sbjct: 3563 AGVLSTTREIDRE-----QIADFYLSVVTKDSGVPQMSSTGTVHITVI--DQNDNPS--Q 3613
Query: 347 KFTFSIMV 354
T I V
Sbjct: 3614 SRTVEIFV 3621
Score = 58.9 bits (141), Expect = 2e-08
Identities = 65/242 (26%), Positives = 111/242 (45%), Gaps = 20/242 (8%)
Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90
++E P GT V S S S+ P F + S AF +N +G ++ T
Sbjct: 3413 ISEGVPIGTHVTFVSAFDSDSI-PSWSRFSYFIGSGNENGAFSINPQTG---QITVTA-- 3466
Query: 91 QLDFETGPNIFDLQIYVKDE--VGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERA 148
+LD ET P I++L + D T L V + D+N+ ++EG ++E
Sbjct: 3467 ELDRETLP-IYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPML-TVSEG---EVMENK 3521
Query: 149 NPG-FIYQVEAFDPEDTSRNIPLSYFLIS--PPKS-FRMSANGTLFSTTELDFEAGHRSF 204
PG + +++ DP+ P +Y+L+S P S F +S G L +T E+D E F
Sbjct: 3522 RPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQ-IADF 3580
Query: 205 HLIVEVRDSG--GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAED 262
+L V +DSG + ++ + + +++ ND + + L PG I+ ++ +D
Sbjct: 3581 YLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQD 3640
Query: 263 PD 264
PD
Sbjct: 3641 PD 3642
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 130 bits (328), Expect = 4e-30
Identities = 163/617 (26%), Positives = 258/617 (41%), Gaps = 61/617 (9%)
Query: 23 ILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYF 82
I LP + N+ E+SPPGT+V + P G + S F ++++SG
Sbjct: 237 INLPYSTNIYEHSPPGTTVRIITAIDQDKGRP--RGIGYTIVSGNTNSIFALDYISGVLT 294
Query: 83 EVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT---VQVTDVNE-PPQFQGNLAE 138
E + G + + D+ +D V T + V D+N+ P+F +
Sbjct: 295 LNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFN---SS 351
Query: 139 GLHLYIVERANPGFIYQVEAFDPEDTSRNIPL------------SYFLISPPKSFRMSAN 186
+ I E A GF + D N+ L S+ I P S + A+
Sbjct: 352 EYSVAITELAQVGFALPL-FIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKAD 410
Query: 187 GTLFSTTELDFEAGHR-SFHLIV--EVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVY 243
+ LD+E R F L V D G ++++ ++N ND P F+ P
Sbjct: 411 IRIRVAIPLDYETVDRYDFDLFANESVPDHVGY---AKVKITLINENDNRPIFSQPLYNI 467
Query: 244 TVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAG 303
++ E ++ GT V + A D +D G + Y + F +++ TG I + R+D
Sbjct: 468 SLYENVTVGTSVLTVLATD-NDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDY--- 523
Query: 304 ELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTL 363
EL Q T+++ R GG+E ++ V DVNDN T QK + + E T
Sbjct: 524 ELIQRFTLTIIA----RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ 579
Query: 364 LLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRF-LQDPAGSGKIVLIGDLDYENPSNLA 422
L+ L D+ PNN+ +++ S GS F + G G I + LDYE SN
Sbjct: 580 LVRLRA---TDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISN-- 634
Query: 423 AGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQ 482
G Y + + D P + V V I EN+ P F +P+Y V E A V
Sbjct: 635 -GLIY-LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLF 692
Query: 483 VRATD----KDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILR 538
+ ATD ++ Q S++Y SL+ F IN ++GE+ + +D ET YIL
Sbjct: 693 LNATDLDRSREYGQESIIY-------SLEGSTQFRINARSGEITTTSLLDRETKSEYILI 745
Query: 539 IQAT-----NNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCT 593
++A +N+ T TV + +L+ ND P Y++ L +++
Sbjct: 746 VRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP 805
Query: 594 DLDSSPRSFRYSIGPGN 610
DL + + YSI P N
Sbjct: 806 DLGEN-GTLVYSIQPPN 821
Score = 125 bits (315), Expect = 1e-28
Identities = 162/630 (25%), Positives = 262/630 (41%), Gaps = 64/630 (10%)
Query: 28 TGNVAENSPPGTSVHKFSV---KLSASLSPVIPGFPQIVNSNPLT----EAFRVNWLSGT 80
T +V E++ PGT + + L+ L I G +++ L +AF VN +G+
Sbjct: 2180 TVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239
Query: 81 YFEVVTTGMEQL-DFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAE 138
E + +E ++ D + + LTV V DVN+ PQF+
Sbjct: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFK---PF 2296
Query: 139 GLHLY---IVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS--PPKSFRM--SANGTLF 190
G+ Y I+E A PG + V A DP D N ++Y L+ PP ++ S+ G +
Sbjct: 2297 GITYYMERILEGATPGTTLIAVAAVDP-DKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVI 2355
Query: 191 STTELDFEAGHRSFHLIVEVRDSGGLKASTELQV--NIVNLNDEVPRFTSPTRVYTVLEE 248
+ +D+E H + V D+G + E+ V IV++ND P F P+ V E+
Sbjct: 2356 ANRTVDYEEVHW-LNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFED 2414
Query: 249 LSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQN 308
+ GTI+ +TA D D F + + YS+ F IN TG I V +DR+ +
Sbjct: 2415 VPVGTIILTVTATDADSGNF-ALIEYSLGDGESKFAINPTTGDIYVLSSLDRE-----KK 2468
Query: 309 PTISLEVLVKDRP----YGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLL 364
L L KD P +EN +Q+ V DVND K FS V E GT +
Sbjct: 2469 DHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSV 2528
Query: 365 LDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAG 424
+ + D E PN +++ G G SG + + P L +
Sbjct: 2529 ITMMA---TDQDEGPNGELTYSLE---GPGVEAFHVDMDSGLVTT------QRP--LQSY 2574
Query: 425 NKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP--SYVFDVSERRPARTRVGQ 482
K+++ + D P + + N+ +F RP + + E P R+ V +
Sbjct: 2575 EKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE 2634
Query: 483 VRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA 541
V ATDKD ++ YS + + F I+P +G +Q ++D E+ +Y L + A
Sbjct: 2635 VYATDKDEGLNGAVRYSFLKTAGNRDW-EFFIIDPISGLIQTAQRLDRESQAVYSLILVA 2693
Query: 542 TN------NEDTSSVTVTVNILEEND----EKPICTPNSYFLALPVDLKVGTNIQNFKLT 591
++ E + V + +++N+ P +P L +P GT + N
Sbjct: 2694 SDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNV-TG 2752
Query: 592 CTDLDSSPRSF-RYSIGPGNVNNHFTFSPN 620
D D P + Y I GN +F P+
Sbjct: 2753 AVDADEGPNAIVYYFIAAGNEEKNFHLQPD 2782
Score = 117 bits (294), Expect = 4e-26
Identities = 161/606 (26%), Positives = 248/606 (40%), Gaps = 81/606 (13%)
Query: 98 PNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGF-IYQ 155
P I +L + +D + L + + D N+ P F L ++++E PGF + Q
Sbjct: 2034 PPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS---PATLTVHLLENCPPGFSVLQ 2090
Query: 156 VEAFDPEDTSRNIPLSY---------FLISPPKSFRMSANGTLFSTTELDFEAGHRSFHL 206
V A D ED+ N L Y FLI N T+ + S+ L
Sbjct: 2091 VTATD-EDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQ-------ESYRL 2142
Query: 207 IVEVRDSGGLKASTELQVNIV--NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPD 264
V D G + S V I+ ++ND P F +P + +VLE PGT++ANITA D D
Sbjct: 2143 TVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD 2202
Query: 265 DEGFPSHLLYSITTVSK------------YFMINQLTGTIQVAQRIDRDAGELRQNPTIS 312
P + + V+K F +N TG++ V ++R EL ++
Sbjct: 2203 LN--PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNR---ELVATYEVT 2257
Query: 313 LEVL--VKDRPYGG-QENRIQITFIVEDVNDNPATCQKFTFSI---MVPERTAKGTLLLD 366
L V+ D P ++T V DVNDN + F + + E GT L+
Sbjct: 2258 LSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIA 2317
Query: 367 LNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNK 426
+ D + N +T+ V G L+D + +GK++ +DYE L
Sbjct: 2318 VAAV---DPDKGLNGLVTYTLLDLVPPGYVQLED-SSAGKVIANRTVDYEEVHWL----- 2368
Query: 427 YTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRAT 486
++ D P + VY+ N+ IFD+PSY V E P T + V AT
Sbjct: 2369 -NFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTAT 2427
Query: 487 DKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA---- 541
D D +L+ YS+ G + F INP TG++ +++ +D E YIL A
Sbjct: 2428 DADSGNFALIEYSLGDGESK------FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 2481
Query: 542 ---TNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSS 598
+N +SV V + +L+ ND +P + + ++ + GT++ + TD D
Sbjct: 2482 GDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSV--ITMMATDQDEG 2539
Query: 599 PR-SFRYSI-GPGNVNNHFTFSPNAGSNVTRLLLTSRFDYA-----GGFDKIW-DYKLLV 650
P YS+ GPG H + L +F GG +W LLV
Sbjct: 2540 PNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLV 2599
Query: 651 YVTDDN 656
V D N
Sbjct: 2600 EVIDVN 2605
Score = 114 bits (284), Expect = 5e-25
Identities = 166/666 (24%), Positives = 262/666 (39%), Gaps = 69/666 (10%)
Query: 29 GNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEV---- 84
G + EN P T + V+L A+ P QI S AF G+YF++
Sbjct: 568 GALRENEPSVTQL----VRLRATDEDSPPN-NQITYSIVSASAF------GSYFDISLYE 616
Query: 85 ---VTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQV---LTVQVTDVNE-PPQFQGNLA 137
V + LD+E N + + G L +T++V D N+ PP F
Sbjct: 617 GYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFS---K 673
Query: 138 EGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS--FRMSANGTLFSTTEL 195
+ +VE G D SR + S S FR++A +TT L
Sbjct: 674 PAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSL 733
Query: 196 DFEAGHRSFHLIVEVRDSG-GLKASTEL---QVNIVNLNDEVPRFTSPTRVYTVLEELSP 251
+ LIV D G G T + + ++++ND P + ++E P
Sbjct: 734 LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793
Query: 252 GTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQR-IDR---DAGELRQ 307
+ V + A DPD G L+YSI +K++ +N TG I+ +DR D E
Sbjct: 794 DSDVTTVVAVDPD-LGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAEL 852
Query: 308 NPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDL 367
I + V RP + + + D+NDN T Q F V E G + +
Sbjct: 853 MRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQV 912
Query: 368 NKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKY 427
D E N ++ MP G+ + + SG +V +LD E + +Y
Sbjct: 913 VAIDLD---EGLNGLVSYRMPVGMPRMDFLIN--SSSGVVVTTTELDRERIA------EY 961
Query: 428 TVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATD 487
+ + D P + + I N+ F Y VSE P RV + TD
Sbjct: 962 QLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTD 1021
Query: 488 KDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--- 544
D+ ++ L TGG F + + ++ V +D ETT Y+L ++A +N
Sbjct: 1022 NDVGLNAELSYFITGG---NVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPV 1078
Query: 545 --EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSF 602
T + TV V +L+ ND +PI +SY ++P D+ G +I K T D R +
Sbjct: 1079 GKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVW 1138
Query: 603 RYSIGPGNVNNHFTFSPNAG------------SNVTRLLLTSRFDYAGGFDKIWDYKLLV 650
Y I GN N+F + G N + +L+ +++ G + +++V
Sbjct: 1139 -YRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRS-SVRVIV 1196
Query: 651 YVTDDN 656
YV D N
Sbjct: 1197 YVEDIN 1202
Score = 112 bits (279), Expect = 2e-24
Identities = 169/702 (24%), Positives = 288/702 (41%), Gaps = 106/702 (15%)
Query: 30 NVAENSPP-GTSVHKFSVKLSASLSPVIPGFPQIVNSNP---LTEAFRVNWLSGT--YFE 83
++ +N+P +S + ++ A + +P F Q+V+ + L F V + +F
Sbjct: 340 DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFI 399
Query: 84 VVTTGME-----------QLDFETGPNIFDLQIY----VKDEVGVTDLQVLTVQVTDVNE 128
+ T ++ LD+ET +D ++ V D VG +++ + D
Sbjct: 400 ISPTSVQGKADIRIRVAIPLDYETVDR-YDFDLFANESVPDHVGYAKVKITLINEND--N 456
Query: 129 PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN-G 187
P F L ++ + E G D +SYF P F + + G
Sbjct: 457 RPIFSQPL---YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 513
Query: 188 TLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLE 247
+ LD+E R F L + RD GG + + +++N++++ND VP F V + E
Sbjct: 514 LIMLIARLDYELIQR-FTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRE 572
Query: 248 ELSPGTIVANITAEDPDDEGFPSHLLYSITTVS---KYFMIN--QLTGTIQVAQRIDRDA 302
T + + A D +D + + YSI + S YF I+ + G I V++ +D
Sbjct: 573 NEPSVTQLVRLRATD-EDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDY-- 629
Query: 303 GELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGT 362
E N I L V+ D + + +T V D NDNP T K + + V E G
Sbjct: 630 -EQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGA 688
Query: 363 LLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLA 422
+L LN D E +++ GS + A SG+I LD E S
Sbjct: 689 TVLFLNATDLDRSREYGQESIIYSL-----EGSTQFRINARSGEITTTSLLDRETKS--- 740
Query: 423 AGNKYTVIIQVQDVAPPYYKN----NVYVYILTSPENEFPLIFDRPSYVFDVSERRPART 478
+Y +I++ D + + V + +L +N P D P Y+ ++ E P +
Sbjct: 741 ---EYILIVRAVDGGVGHNQKTGIATVNITLLDINDNH-PTWKDAPYYI-NLVEMTPPDS 795
Query: 479 RVGQVRATDKDLPQS-SLLYSI-----------STGGASLQYPNVFWINPKTGELQLVTK 526
V V A D DL ++ +L+YSI +TG + + NP E +L+ K
Sbjct: 796 DVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK 855
Query: 527 V-----DCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKV 581
+ DC P+ + TSS TV VN+L+ ND P + + +
Sbjct: 856 IVVSVTDCGRPPL----------KATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905
Query: 582 GTNIQNFKLTCTDLDSSPR---SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAG 638
G +I +++ DLD S+R +G ++ F N+ S V ++ T+ D
Sbjct: 906 GVSI--YQVVAIDLDEGLNGLVSYRMPVGMPRMD----FLINSSSGV--VVTTTELDR-- 955
Query: 639 GFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVI 680
++I +Y+L V +D A ++ T TL+I V+
Sbjct: 956 --ERIAEYQLRVVASD---------AGTPTKSSTSTLTIHVL 986
Score = 88.2 bits (217), Expect = 3e-17
Identities = 127/540 (23%), Positives = 221/540 (40%), Gaps = 66/540 (12%)
Query: 185 ANGTLFSTTELDFEAGHRSFHLIVEVRDSGGL--KASTELQVNIVNLNDEVPRFTSPTRV 242
+ G + + LD+E S+ + V D + + + ++N DE +F++ +
Sbjct: 1261 STGLIITVNYLDYET-KTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYE 1319
Query: 243 YTVLEELSPGTIVANITAEDPDDEGFPSHLL--YSITTVSKYFMINQLTGTIQVAQRIDR 300
+LE L+ GT + + A D+ ++ Y+ T F I+ +TG I V +DR
Sbjct: 1320 AAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDR 1379
Query: 301 DAGELRQNPTISLEVLVKDRPYGGQ--ENRIQITFIVEDVNDNPATCQKFTFS----IMV 354
+ G+ +L V+ D GG ++ +++ V D NDN +F F+ + +
Sbjct: 1380 EKGDF-----YTLTVVADD---GGPKVDSTVKVYITVLDENDNSP---RFDFTSDSAVSI 1428
Query: 355 PERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVL----I 410
PE G + + + D N + F++ SG + AG+ +IV I
Sbjct: 1429 PEDCPVGQRVATVKAW---DPDAGSNGQVVFSLASG---------NIAGAFEIVTTNDSI 1476
Query: 411 GDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP-SYVFD 469
G++ P + + Y + + D P K + + + N+ P + + P Y
Sbjct: 1477 GEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVS 1536
Query: 470 VSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQL-VTKV 527
V+E T V QVRATD+D+ +S+L Y I+ G + F ++ +GE+
Sbjct: 1537 VNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDM----AFRMDRISGEIATRPAPP 1592
Query: 528 DCETTPIYILRIQATNNEDTSSVTVT----VNILEENDEKPICTPNSYFLALPVDLKVGT 583
D E Y L + +E T +++ T V I++END P+ Y + L
Sbjct: 1593 DRERQSFYHL-VATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDT-L 1650
Query: 584 NIQNFKLTCTDLDSSPR-SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDK 642
N + DLD P + Y+I GN+ N F + G + DY +
Sbjct: 1651 NTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV----ITAAKELDYEISHGR 1706
Query: 643 IWDYKLLVYVTDD-NLMSDR--KKAEALVETGTVTLSIKVIPH----PTTIITTTPRPRV 695
Y L+V TD ++S R LV + ++ P P + P PRV
Sbjct: 1707 ---YTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRV 1763
Score = 85.5 bits (210), Expect = 2e-16
Identities = 137/551 (24%), Positives = 232/551 (42%), Gaps = 51/551 (9%)
Query: 71 AFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE-- 128
AFR++ +SG + T D E + + L V+DE T V VT V+E
Sbjct: 1575 AFRMDRISGE----IATRPAPPDRER-QSFYHLVATVEDEGTPTLSATTHVYVTIVDEND 1629
Query: 129 -PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPP--KSFRMSA 185
P FQ E L + N I ++A D D N ++Y +++ +FR+
Sbjct: 1630 NAPMFQQPHYEVLLDEGPDTLNTSLI-TIQALDL-DEGPNGTVTYAIVAGNIVNTFRIDR 1687
Query: 186 N-GTLFSTTELDFEAGHRSFHLIVEVRD-----SGGLKASTELQVNIVNLNDEVPRFTSP 239
+ G + + ELD+E H + LIV D S L ++T + VN+ ++ND VP F
Sbjct: 1688 HMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRD 1747
Query: 240 TRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FMINQLTGTIQVAQR 297
+ E PG V A D D G + YSI F+I+ + G ++V +
Sbjct: 1748 YEGPFEVTEGQPGPRVWTFLAHD-RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKD 1806
Query: 298 IDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPER 357
++ D + +L + +DR + + + V D+NDN +I + E
Sbjct: 1807 VELDRETI---AFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISEN 1863
Query: 358 TAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYEN 417
+ + + + D DS N R F + +G + F+ A +G + + LD E
Sbjct: 1864 SPVSSFVAHV--LASDADSGC-NARLTFNITAGNRERAFFIN--ATTGIVTVNRPLDRER 1918
Query: 418 PSNLAAGNKYTVIIQVQD-VAPPYYKNNVY--VYILTSPENEFPLIFDRPSYVFDVSERR 474
+Y + I V+D P Y + I S EN+ +F + +Y +V E
Sbjct: 1919 IP------EYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENS 1972
Query: 475 PARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKV----DCE 530
PA T + + L +Y++ T +F IN TG + + + V +
Sbjct: 1973 PAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAF 2032
Query: 531 TTPIYILRIQATNNED----TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586
+ PI L + A ED S+ + + IL++ND +P +P + + L + G ++
Sbjct: 2033 SPPILELLLLA---EDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV- 2088
Query: 587 NFKLTCTDLDS 597
++T TD DS
Sbjct: 2089 -LQVTATDEDS 2098
Score = 80.9 bits (198), Expect = 5e-15
Identities = 107/411 (26%), Positives = 180/411 (43%), Gaps = 45/411 (10%)
Query: 243 YTVLEELSP-GTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRD 301
Y ++ E +P G+ V + A+D D++ P S S++F + TG + + Q +DR+
Sbjct: 39 YLLISEDTPVGSSVTQLLAQDMDND--PLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRE 96
Query: 302 AGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361
++E V D + G R ++ V DVNDN T +S+ +PE T G
Sbjct: 97 T-----KSEFTVEFSVSD--HQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVG 148
Query: 362 TLLLDLNKFCFDDDSEAPNN-RFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN 420
T + +N D D A + ++F P S+F + G + +I +LDYE
Sbjct: 149 TPIFIVN--ATDPDLGAGGSVLYSFQPP------SQFFAIDSARGIVTVIRELDYET--- 197
Query: 421 LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV 480
+ TV QD P I+T ++ P+ + P Y ++ E P T V
Sbjct: 198 -TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP-YSTNIYEHSPPGTTV 255
Query: 481 GQVRATDKDLPQ-SSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIY---- 535
+ A D+D + + Y+I +G + ++F ++ +G L L +D E P+Y
Sbjct: 256 RIITAIDQDKGRPRGIGYTIVSGNTN----SIFALDYISGVLTLNGLLDRE-NPLYSHGF 310
Query: 536 ILRIQATNNED-----TSSVTVTVNIL--EENDEKPICTPNSYFLALPVDLKVGTNIQNF 588
IL ++ T D ++VT T NIL + ND P + Y +A+ +VG + F
Sbjct: 311 ILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF 370
Query: 589 -KLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNA--GSNVTRLLLTSRFDY 636
++ D + S GN ++HF SP + G R+ + DY
Sbjct: 371 IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDY 421
Score = 80.5 bits (197), Expect = 6e-15
Identities = 124/551 (22%), Positives = 221/551 (40%), Gaps = 46/551 (8%)
Query: 180 SFRMSANGTLFSTTELDFEAGHRSFH-LIVEV--RDSGGLKASTELQVNIVNLNDEVPRF 236
+FR+ + L + S H LIVE D G +++S + V + ++NDE P F
Sbjct: 1149 NFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVF 1208
Query: 237 TSPTRVYTVLEE---LSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
T L E + IV T D D G ++ + ++ F I++ TG I
Sbjct: 1209 TQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRI--LSGAEGKFEIDESTGLII 1266
Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIM 353
+D E + + +++ + P+ + IT + E D ++
Sbjct: 1267 TVNYLDY---ETKTSYMMNVSATDQAPPFNQGFCSVYITLLNE--LDEAVQFSNASYEAA 1321
Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413
+ E A GT ++ + + D+ ++ + F + + + F D A +G I + G +
Sbjct: 1322 ILENLALGTEIVRVQAYSIDNLNQI---TYRFNAYTSTQAKALFKID-AITGVITVQGLV 1377
Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPS-YVFDVSE 472
D E G+ YT+ + V D P + V VYI EN+ FD S + E
Sbjct: 1378 DREK------GDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPE 1430
Query: 473 RRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531
P RV V+A D D +++S+++G + + + N GE+ + +D E
Sbjct: 1431 DCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAF-EIVTTNDSIGEVFVARPLDREE 1489
Query: 532 TPIYILRIQATNN---EDTSSVTVTVNILEENDEKPIC-TPNSYFLALPVDLKVGTNIQN 587
YIL++ A++ + V IL+ ND P+ +P Y +++ ++ GT +
Sbjct: 1490 LDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQ 1549
Query: 588 FKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTR-------------LLLTSRF 634
+ T D+ + Y I GN + F +G TR L+ T
Sbjct: 1550 VRATDRDIGIN-SVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVED 1608
Query: 635 DYAGGFDKIWD-YKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPHPTTIITTTPRP 693
+ Y +V D+ M + E L++ G TL+ +I + P
Sbjct: 1609 EGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNG 1668
Query: 694 RVTYQVLRKNV 704
VTY ++ N+
Sbjct: 1669 TVTYAIVAGNI 1679
Score = 72.4 bits (176), Expect = 2e-12
Identities = 121/566 (21%), Positives = 220/566 (38%), Gaps = 91/566 (16%)
Query: 187 GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVL 246
G ++ LD E F + V D G+ + ++ + + ++ND P F + +
Sbjct: 85 GVVWLRQPLDRET-KSEFTVEFSVSDHQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIP 142
Query: 247 EELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELR 306
E GT + + A DP D G +LYS S++F I+ G + V + +D + +
Sbjct: 143 ENTPVGTPIFIVNATDP-DLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAY 201
Query: 307 QNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLD 366
Q T++ K RP N + I+ DV D +S + E + GT +
Sbjct: 202 Q-LTVNATDQDKTRPLSTLAN---LAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRI 257
Query: 367 LNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYEN--------- 417
+ D D P +T+ SG + S F D SG + L G LD EN
Sbjct: 258 IT--AIDQDKGRPRG-IGYTIVSG-NTNSIFALDYI-SGVLTLNGLLDRENPLYSHGFIL 312
Query: 418 ------------PSNLAAGNKYTV-IIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP 464
PS+ + + +I + D AP + + V I + F L P
Sbjct: 313 TVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL----P 368
Query: 465 SYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGE---- 520
++ QV D++L +S+ G S + F I+P + +
Sbjct: 369 LFI--------------QVVDKDENLGLNSMFEVYLVGNNS----HHFIISPTSVQGKAD 410
Query: 521 --LQLVTKVDCETTPIYILRIQATNN--EDTSSVTVTVNILEENDEKPICTPNSYFLALP 576
+++ +D ET Y + A + + V + ++ END +PI + Y ++L
Sbjct: 411 IRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLY 470
Query: 577 VDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGS---NVTRLLLTSR 633
++ VGT++ LT D+ +F G V+ F+ P+ S + ++L +R
Sbjct: 471 ENVTVGTSV----LTVLATDNDAGTF------GEVSYFFSDDPDRFSLDKDTGLIMLIAR 520
Query: 634 FDY--------------AGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKV 679
DY GG + ++ V +DN+ + +K A ++
Sbjct: 521 LDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQL 580
Query: 680 IPHPTTIITTTPRPRVTYQVLRKNVY 705
+ T + P ++TY ++ + +
Sbjct: 581 VRLRATDEDSPPNNQITYSIVSASAF 606
Score = 67.0 bits (162), Expect = 7e-11
Identities = 99/415 (23%), Positives = 179/415 (43%), Gaps = 63/415 (15%)
Query: 119 LTVQVTDVNE------PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSY 172
+ +QV DVN+ PQF ++ E E A I + +D N L+Y
Sbjct: 2495 VVIQVLDVNDCRPQFSKPQFSTSVYEN------EPAGTSVITMMAT--DQDEGPNGELTY 2546
Query: 173 FLISPP-KSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNL 229
L P ++F + + L TT+ ++ + F L V D G L +T L V ++++
Sbjct: 2547 SLEGPGVEAFHVDMDSGLV-TTQRPLQS-YEKFSLTVVATDGGEPPLWGTTMLLVEVIDV 2604
Query: 230 NDEVPRFTSPTR--VYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS-----KY 282
ND P F P + + EE+ + V + A D D EG + YS + ++
Sbjct: 2605 NDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKD-EGLNGAVRYSFLKTAGNRDWEF 2663
Query: 283 FMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDN- 341
F+I+ ++G IQ AQR+DR++ + ++ + L + PY E + +ED++DN
Sbjct: 2664 FIIDPISGLIQTAQRLDRESQAVYSLILVASD-LGQPVPY---ETMQPLQVALEDIDDNE 2719
Query: 342 ------PATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGS 395
P ++ + VPE + +GTL+ ++ D E PN + + +G +
Sbjct: 2720 PLFVRPPKGSPQYQL-LTVPEHSPRGTLVGNVTGAV--DADEGPNAIVYYFIAAGNEEKN 2776
Query: 396 RFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV---QDVAPPYYKNNVY------ 446
LQ G ++++ DLD E + ++ I++ + PP +
Sbjct: 2777 FHLQP---DGCLLVLRDLDREREA------IFSFIVKASSNRSWTPPRGPSPTLDLVADL 2827
Query: 447 ----VYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLY 497
V ++ N+ P F + Y V+ + + QV A D D+ +SL++
Sbjct: 2828 TLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882
Score = 58.2 bits (139), Expect = 3e-08
Identities = 139/596 (23%), Positives = 224/596 (37%), Gaps = 113/596 (18%)
Query: 80 TYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEG 139
T ++V G QL+ + + + +EV + TV+ +D PP+ +
Sbjct: 2334 TLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNF---TVRASDNGSPPR-AAEIPVY 2389
Query: 140 LHLYIVERANPGF---IYQVEAFDP--------------EDTSRNIPLSYFLISPPKSFR 182
L + + NP F YQ F+ D+ + Y L F
Sbjct: 2390 LEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFA 2449
Query: 183 MS-ANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKAST------ELQVNIVNLNDEVPR 235
++ G ++ + LD E + L +D+ G AS ++ + ++++ND P+
Sbjct: 2450 INPTTGDIYVLSSLDREKKDH-YILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQ 2508
Query: 236 FTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVA 295
F+ P +V E GT V + A D DEG L YS L G A
Sbjct: 2509 FSKPQFSTSVYENEPAGTSVITMMATD-QDEGPNGELTYS------------LEGPGVEA 2555
Query: 296 QRIDRDAG------ELRQNPTISLEVLVKDRPYGGQENRIQITFI---VEDVNDNPATCQ 346
+D D+G L+ SL V+ D GG+ T + V DVNDN
Sbjct: 2556 FHVDMDSGLVTTQRPLQSYEKFSLTVVATD---GGEPPLWGTTMLLVEVIDVNDNRP--- 2609
Query: 347 KFTFSIMVPERTAKGTLL-----LDLNKFCFD----DDSEAPNN--RFNFTMPSGVGSGS 395
V R GT+L + L ++ D E N R++F +G
Sbjct: 2610 -------VFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWE 2662
Query: 396 RFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY-YKNNVYVYILTSPE 454
F+ DP SG I LD E+ + Y++I+ D+ P Y+ + +
Sbjct: 2663 FFIIDPI-SGLIQTAQRLDRESQA------VYSLILVASDLGQPVPYETMQPLQVALEDI 2715
Query: 455 NEFPLIFDRPS------YVFDVSERRPARTRVGQVR-ATDKDL-PQSSLLYSISTGGASL 506
++ +F RP + V E P T VG V A D D P + + Y I+ G
Sbjct: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEK 2775
Query: 507 QYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNE----------------DTSSV 550
F + P G L ++ +D E I+ ++A++N D +
Sbjct: 2776 N----FHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQ 2830
Query: 551 TVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSI 606
V V + + ND+ P T Y + D KVG+ + D+ ++ F YSI
Sbjct: 2831 EVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF-YSI 2885
>gi|203097724 cadherin-like 29 [Homo sapiens]
Length = 788
Score = 127 bits (320), Expect = 3e-29
Identities = 200/852 (23%), Positives = 329/852 (38%), Gaps = 120/852 (14%)
Query: 5 IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSA-SLSPVIPGFPQIV 63
++LL LL + L LP NV+E+ PGT + S S+ + +P + +++
Sbjct: 1 MVLLRLLVFLFAPVVSDLCSLPCFINVSESQGPGTVLQFLSFNCSSYTPTPTL----ELL 56
Query: 64 NSNPLTEAFRVNWLS---GTYFEVVTTGME-------------QLDFETGPNIFDLQIYV 107
N P T F L+ GTY +T QL F G ++ + + V
Sbjct: 57 NVQPPTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSV 116
Query: 108 KDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIY---QVEAFDPEDT 164
+ ++ +Q + E Q + G LY + PG Q+ +D
Sbjct: 117 DVQRDLSHIQCAGQFASPAGEMIQVPETVTPGARLYTL--LLPGLELHGAQMSIISAQD- 173
Query: 165 SRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQV 224
L +F P F ++ G L + ++ + F L + V + V
Sbjct: 174 -----LPHF----PGPFSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIV 224
Query: 225 NIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTV--SKY 282
++ + F + T+ E L+PG+ V + A D L Y I + S
Sbjct: 225 KVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD-------LRYEILSPVPSPL 277
Query: 283 FMINQLTGTIQVAQRID--RDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVND 340
F I + G ++ ++ R +G L+V ++ ++ +T V+ VN
Sbjct: 278 FSIGRADGVVRTTTPLELARTSG----TAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNL 333
Query: 341 NPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQD 400
P C +PE GT+L L C D DS + S S L D
Sbjct: 334 WPPRCLPALLVSQIPETAPVGTVLNTLT--CEDPDSVGATLDYKLWFRSSSNPASLCLYD 391
Query: 401 PAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEF-PL 459
+ + LD + P A ++ I V D P V V ++ +P NEF P
Sbjct: 392 RV----LEVNATLDCDTPG---ACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPA 444
Query: 460 IFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTG 519
R F V E T +G V TD D P ++ Y S G P F ++ +G
Sbjct: 445 CAPR---TFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGG------PTTFAVDRLSG 495
Query: 520 ELQLVTKVDCETTPIYILRI--------QATNNEDTSSVTVTVNILEENDEKPICTPNSY 571
E+ L+ +D E +Y L + Q N+ + S T+T+ + + ND P C P
Sbjct: 496 EVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPP-- 553
Query: 572 FLALPVDLKVGTNIQNFKLTCTDLDSSPRS--FRYSIGPGNVNNHFTFSPNAGSNVTRLL 629
F L + +G +++ K++C + P+ + YSI GN N F +
Sbjct: 554 FQELTIYAPLGRSVEVTKMSC-QIPQEPQRLIYSYSIVGGNSQNRFILQG--------AI 604
Query: 630 LTSRFDYAGGF--DKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPH-PTTI 686
L G F ++ Y+LL+ V D + T T+ + ++P +T+
Sbjct: 605 LVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLST-------TATIIVHLVPRRASTV 657
Query: 687 ITTTPRPRVTYQVLRKNV------YSPSAWYVPFVITLGSILLLGL---LVYLVVLLAKA 737
T+T R V + V + P W+V + G++LLL L L L+ LA+
Sbjct: 658 ATSTHRTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALLLLALGWLLGRLLQGLAQL 717
Query: 738 IHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTI--------FDGEAIDPVTGET 789
+ P K + + +G + E + ++M+ FDG A D TG
Sbjct: 718 LQ--APSKPAQALLLNSIQGTEGSIEGFLEAPKMEMSQAPSSVMSLHFDGRAQDSRTGRD 775
Query: 790 YEFNSKTGARKW 801
Y FN+ TGAR+W
Sbjct: 776 YLFNTHTGARRW 787
>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 124 bits (312), Expect = 3e-28
Identities = 122/464 (26%), Positives = 201/464 (43%), Gaps = 31/464 (6%)
Query: 187 GTLFSTTELDFEAG-HRSFHL-IVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYT 244
G + ST LD E H H ++ R + L+ +E + + ++ND P+FT + T
Sbjct: 108 GDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVT 167
Query: 245 VLEELSPGTIVANITAEDPDDE--GFPSHLLYSITTVSKYFMINQLTGTIQVA-QRIDRD 301
V E GT V +TA D DD G + ++YSI YF ++ TG I+ A +DR+
Sbjct: 168 VPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDRE 227
Query: 302 AGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361
A R++ ++ ++ GG + + DVNDNP + + + VPE G
Sbjct: 228 A---REHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQVG 284
Query: 362 TLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNL 421
+ + K +D N +++ +G G G + + K G L + P N
Sbjct: 285 SA---VGKIKANDADTGSNADMTYSIINGDGMGIFSI----STDKETREGILSLKKPLNY 337
Query: 422 AAGNKYTVIIQVQDVAPPY-------YKNNVYVYILTSPENEFPLIFDRPSYVFDVSERR 474
YT+ I+ + + +K+ + I+ +E PL F PSY+ +V E
Sbjct: 338 EKKKSYTLNIEGANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPL-FSMPSYLMEVYENA 396
Query: 475 PARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPI 534
T VG V A D D S + Y I+ +++ F I+ TG ++ +D E TP
Sbjct: 397 KIGTVVGTVLAQDPDSTNSLVRYFIN---YNVEDDRFFNIDANTGTIRTTKVLDREETPW 453
Query: 535 YILRIQAT---NNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLT 591
Y + + A+ N + S VTV + +L+ ND P Y + + + K G I T
Sbjct: 454 YNITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELA-REYDIIVCENSKPGQVIHTISAT 512
Query: 592 CTDLDSSPRSFRYSIGPG-NVNNHFTFSPNAGSNVTRLLLTSRF 634
D ++ F + + VN +FT N + + L RF
Sbjct: 513 DKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRF 556
Score = 44.7 bits (104), Expect = 4e-04
Identities = 43/157 (27%), Positives = 71/157 (45%), Gaps = 12/157 (7%)
Query: 115 DLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIY-QVEAFDPEDTSRNIPLSYF 173
D +L + V DV+EPP F + + E A G + V A DP+ T N + YF
Sbjct: 366 DATMLKIIVGDVDEPPLFS---MPSYLMEVYENAKIGTVVGTVLAQDPDST--NSLVRYF 420
Query: 174 L---ISPPKSFRMSAN-GTLFSTTELD-FEAGHRSFHLIVEVRDSGGLKASTELQVNIVN 228
+ + + F + AN GT+ +T LD E + + D+ L + + + +++
Sbjct: 421 INYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDLLSHVTVGIRVLD 480
Query: 229 LNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDD 265
+ND P + V E PG ++ I+A D DD
Sbjct: 481 VNDNPPELAREYDI-IVCENSKPGQVIHTISATDKDD 516
Score = 39.3 bits (90), Expect = 0.016
Identities = 36/145 (24%), Positives = 60/145 (41%), Gaps = 16/145 (11%)
Query: 486 TDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA---- 541
++ D S+ Y ++ GA +F I+ TG++ +D E Y+L QA
Sbjct: 79 SNSDKGDGSVKYILTGEGAG----TIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRR 134
Query: 542 TNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLD----S 597
TN + + + ND P T Y + +P +GT++ ++T TD D
Sbjct: 135 TNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDMGTSV--LQVTATDADDPTYG 192
Query: 598 SPRSFRYSIGPGNVNNHFTFSPNAG 622
+ YSI G +F+ P G
Sbjct: 193 NSARVVYSILQG--QPYFSVDPKTG 215
>gi|11056063 protocadherin gamma subfamily A, 7 isoform 1 precursor
[Homo sapiens]
Length = 932
Score = 124 bits (310), Expect = 5e-28
Identities = 136/540 (25%), Positives = 235/540 (43%), Gaps = 57/540 (10%)
Query: 69 TEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE 128
T+ F +N SG+ E++ ++ + + I ++D++ +L + V++ D+N+
Sbjct: 72 TQLFALNQRSGSLVTAGRIDREEICAQSARCLVNFNILMEDKM---NLYPIDVEIIDIND 128
Query: 129 P-PQFQGNLAEGLHLYIVERANPGFIYQV-EAFDPEDTSRNIPLSYFLISPPKSFRMSAN 186
P+F L E +++ I+E PG + + EA DP D N SY L SP + F ++
Sbjct: 129 NVPRF---LTEEINVKIMENTAPGVRFPLSEAGDP-DVGTNSLQSYQL-SPNRHFSLAVQ 183
Query: 187 G--------TLFSTTELDFEAGHRSFHLIVEVRDSGGLKAST--ELQVNIVNLNDEVPRF 236
L LD E R HL++ D G S+ +QV +V++ND P F
Sbjct: 184 SGDDETKYPELVLERVLDREE-ERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVF 242
Query: 237 TSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS----KYFMINQLTGTI 292
+ P TV E + GT + + A D DEG + YS ++ K F +N LTG I
Sbjct: 243 SLPQYQVTVPENVPVGTRLLTVHAIDL-DEGVNGEVTYSFRKITPKLPKMFHLNSLTGEI 301
Query: 293 QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352
+ +D + + +EV +D P G + ++ V DVNDN + S
Sbjct: 302 STLEGLDYE-----ETAFYEMEVQAQDGP--GSLTKAKVLITVLDVNDNAPEVTMTSLSS 354
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412
+PE T GT++ F D N T+P + + + ++V +
Sbjct: 355 SIPEDTPLGTVIA---LFYLQDRDSGKNGEVTCTIPENL--PFKLEKSIDNYYRLVTTKN 409
Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472
LD E S Y + ++ D P ++++ + N+ P F SY ++E
Sbjct: 410 LDRETLS------LYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAE 463
Query: 473 RRPARTRVGQVRATDKDLPQSS-LLYSISTG---GASLQYPNVFWINPKTGELQLVTKVD 528
P + V A D D ++ + YS++ GA + + IN TG L + D
Sbjct: 464 NNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVS--SYVSINSDTGVLYALQSFD 521
Query: 529 CETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI 585
E LR+ A ++ D +S++++++ +L++ND P + ALP D G +
Sbjct: 522 YEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDN----PPEILYPALPTDGSTGMEL 577
Score = 82.8 bits (203), Expect = 1e-15
Identities = 94/391 (24%), Positives = 158/391 (40%), Gaps = 50/391 (12%)
Query: 242 VYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTV-----SKYFMINQLTGTIQVAQ 296
+Y+V EE G+ V +I A+D E P L + ++ F +NQ +G++ A
Sbjct: 32 LYSVSEETDKGSFVGDI-AKDLGLE--PRELAERGVRIISRGRTQLFALNQRSGSLVTAG 88
Query: 297 RIDRDAGELRQ-NPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVP 355
RIDR+ + ++ +L++D+ N I + D+NDN ++ +
Sbjct: 89 RIDREEICAQSARCLVNFNILMEDKM-----NLYPIDVEIIDINDNVPRFLTEEINVKIM 143
Query: 356 ERTAKGTLLL-------DLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408
E TA G D+ +PN F+ + SG D ++V
Sbjct: 144 ENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSG--------DDETKYPELV 195
Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468
L LD E + +++ D P + ++ + N+ +F P Y
Sbjct: 196 LERVLDREEE------RVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV 249
Query: 469 DVSERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKV 527
V E P TR+ V A D D + YS L P +F +N TGE+ + +
Sbjct: 250 TVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKL--PKMFHLNSLTGEISTLEGL 307
Query: 528 DCETTPIYILRIQATNNEDT-SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI- 585
D E T Y + +QA + + + V + +L+ ND P T S ++P D +GT I
Sbjct: 308 DYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIA 367
Query: 586 ----------QNFKLTCTDLDSSPRSFRYSI 606
+N ++TCT ++ P SI
Sbjct: 368 LFYLQDRDSGKNGEVTCTIPENLPFKLEKSI 398
>gi|14196477 protocadherin gamma subfamily A, 7 isoform 2 precursor
[Homo sapiens]
Length = 817
Score = 124 bits (310), Expect = 5e-28
Identities = 136/540 (25%), Positives = 235/540 (43%), Gaps = 57/540 (10%)
Query: 69 TEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE 128
T+ F +N SG+ E++ ++ + + I ++D++ +L + V++ D+N+
Sbjct: 72 TQLFALNQRSGSLVTAGRIDREEICAQSARCLVNFNILMEDKM---NLYPIDVEIIDIND 128
Query: 129 P-PQFQGNLAEGLHLYIVERANPGFIYQV-EAFDPEDTSRNIPLSYFLISPPKSFRMSAN 186
P+F L E +++ I+E PG + + EA DP D N SY L SP + F ++
Sbjct: 129 NVPRF---LTEEINVKIMENTAPGVRFPLSEAGDP-DVGTNSLQSYQL-SPNRHFSLAVQ 183
Query: 187 G--------TLFSTTELDFEAGHRSFHLIVEVRDSGGLKAST--ELQVNIVNLNDEVPRF 236
L LD E R HL++ D G S+ +QV +V++ND P F
Sbjct: 184 SGDDETKYPELVLERVLDREE-ERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVF 242
Query: 237 TSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS----KYFMINQLTGTI 292
+ P TV E + GT + + A D DEG + YS ++ K F +N LTG I
Sbjct: 243 SLPQYQVTVPENVPVGTRLLTVHAIDL-DEGVNGEVTYSFRKITPKLPKMFHLNSLTGEI 301
Query: 293 QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352
+ +D + + +EV +D P G + ++ V DVNDN + S
Sbjct: 302 STLEGLDYE-----ETAFYEMEVQAQDGP--GSLTKAKVLITVLDVNDNAPEVTMTSLSS 354
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412
+PE T GT++ F D N T+P + + + ++V +
Sbjct: 355 SIPEDTPLGTVIA---LFYLQDRDSGKNGEVTCTIPENL--PFKLEKSIDNYYRLVTTKN 409
Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472
LD E S Y + ++ D P ++++ + N+ P F SY ++E
Sbjct: 410 LDRETLS------LYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAE 463
Query: 473 RRPARTRVGQVRATDKDLPQSS-LLYSISTG---GASLQYPNVFWINPKTGELQLVTKVD 528
P + V A D D ++ + YS++ GA + + IN TG L + D
Sbjct: 464 NNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVS--SYVSINSDTGVLYALQSFD 521
Query: 529 CETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI 585
E LR+ A ++ D +S++++++ +L++ND P + ALP D G +
Sbjct: 522 YEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDN----PPEILYPALPTDGSTGMEL 577
Score = 82.8 bits (203), Expect = 1e-15
Identities = 94/391 (24%), Positives = 158/391 (40%), Gaps = 50/391 (12%)
Query: 242 VYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTV-----SKYFMINQLTGTIQVAQ 296
+Y+V EE G+ V +I A+D E P L + ++ F +NQ +G++ A
Sbjct: 32 LYSVSEETDKGSFVGDI-AKDLGLE--PRELAERGVRIISRGRTQLFALNQRSGSLVTAG 88
Query: 297 RIDRDAGELRQ-NPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVP 355
RIDR+ + ++ +L++D+ N I + D+NDN ++ +
Sbjct: 89 RIDREEICAQSARCLVNFNILMEDKM-----NLYPIDVEIIDINDNVPRFLTEEINVKIM 143
Query: 356 ERTAKGTLLL-------DLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408
E TA G D+ +PN F+ + SG D ++V
Sbjct: 144 ENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSG--------DDETKYPELV 195
Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468
L LD E + +++ D P + ++ + N+ +F P Y
Sbjct: 196 LERVLDREEE------RVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV 249
Query: 469 DVSERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKV 527
V E P TR+ V A D D + YS L P +F +N TGE+ + +
Sbjct: 250 TVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKL--PKMFHLNSLTGEISTLEGL 307
Query: 528 DCETTPIYILRIQATNNEDT-SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI- 585
D E T Y + +QA + + + V + +L+ ND P T S ++P D +GT I
Sbjct: 308 DYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIA 367
Query: 586 ----------QNFKLTCTDLDSSPRSFRYSI 606
+N ++TCT ++ P SI
Sbjct: 368 LFYLQDRDSGKNGEVTCTIPENLPFKLEKSI 398
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 122 bits (306), Expect = 1e-27
Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)
Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
T A+N+PP S+ +++ + P FPQ++ S ++EA RV +
Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
S TY F + TTG+ + LD E+ + T
Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
+ + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L +
Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758
Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D
Sbjct: 759 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG +
Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875
Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
+ + +D +A Q +I+ V D YG I +T IV+D+ND P K +
Sbjct: 876 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
MV KGT + + + +D++ P + F P+ + +
Sbjct: 934 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983
Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
SG+++ +L+ E P+ + + +++ D P ++ V IL E P
Sbjct: 984 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037
Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
VSE T VG + A + S++YSI +G + F IN TG +
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090
Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
+ +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y
Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150
Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
+ D ++ T++ K T D + S ++R I P F G T +L
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210
Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
R Y +K V TDD KA+ LV + + + V P T++
Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Score = 111 bits (278), Expect = 3e-24
Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)
Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
PG +Y + PED R F P++ +S L DF H+ F L+++
Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366
Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
G L A L + I++ N++ P FT P+ +LE G ++ N+T+
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
+D +D P L+ + + F + Q +T + + Q +DR+ + T +
Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480
Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
+ D G QE+ I I V D NDN T + ++ + V G ++ L D
Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
+ S T VG+ F+ + +G I + ++ + G Y + +Q
Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585
Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T
Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698
Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
S+ TV + + + ND P+ P LP +L V N ++ TD D+
Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753
Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
YS+ GN NN F + N GS T + L ++ DY LV V D + R
Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800
Query: 664 AEALVETGTVTLSIKVI 680
T+TL+IKV+
Sbjct: 801 -------STLTLAIKVL 810
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 122 bits (306), Expect = 1e-27
Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)
Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
T A+N+PP S+ +++ + P FPQ++ S ++EA RV +
Sbjct: 560 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 619
Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
S TY F + TTG+ + LD E+ + T
Sbjct: 620 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 679
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
+ + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L +
Sbjct: 680 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 736
Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D
Sbjct: 737 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 794
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG +
Sbjct: 795 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 853
Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
+ + +D +A Q +I+ V D YG I +T IV+D+ND P K +
Sbjct: 854 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 911
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
MV KGT + + + +D++ P + F P+ + +
Sbjct: 912 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 961
Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
SG+++ +L+ E P+ + + +++ D P ++ V IL E P
Sbjct: 962 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1015
Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
VSE T VG + A + S++YSI +G + F IN TG +
Sbjct: 1016 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1068
Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
+ +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y
Sbjct: 1069 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1128
Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
+ D ++ T++ K T D + S ++R I P F G T +L
Sbjct: 1129 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1188
Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
R Y +K V TDD KA+ LV + + + V P T++
Sbjct: 1189 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
Score = 111 bits (278), Expect = 3e-24
Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)
Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
PG +Y + PED R F P++ +S L DF H+ F L+++
Sbjct: 298 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 344
Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
G L A L + I++ N++ P FT P+ +LE G ++ N+T+
Sbjct: 345 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 404
Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
+D +D P L+ + + F + Q +T + + Q +DR+ + T +
Sbjct: 405 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 458
Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
+ D G QE+ I I V D NDN T + ++ + V G ++ L D
Sbjct: 459 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515
Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
+ S T VG+ F+ + +G I + ++ + G Y + +Q
Sbjct: 516 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 563
Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++
Sbjct: 564 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 622
Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T
Sbjct: 623 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 676
Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
S+ TV + + + ND P+ P LP +L V N ++ TD D+
Sbjct: 677 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 731
Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
YS+ GN NN F + N GS T + L ++ DY LV V D + R
Sbjct: 732 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 778
Query: 664 AEALVETGTVTLSIKVI 680
T+TL+IKV+
Sbjct: 779 -------STLTLAIKVL 788
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 122 bits (306), Expect = 1e-27
Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)
Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
T A+N+PP S+ +++ + P FPQ++ S ++EA RV +
Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
S TY F + TTG+ + LD E+ + T
Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
+ + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L +
Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758
Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D
Sbjct: 759 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG +
Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875
Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
+ + +D +A Q +I+ V D YG I +T IV+D+ND P K +
Sbjct: 876 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
MV KGT + + + +D++ P + F P+ + +
Sbjct: 934 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983
Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
SG+++ +L+ E P+ + + +++ D P ++ V IL E P
Sbjct: 984 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037
Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
VSE T VG + A + S++YSI +G + F IN TG +
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090
Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
+ +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y
Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150
Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
+ D ++ T++ K T D + S ++R I P F G T +L
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210
Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
R Y +K V TDD KA+ LV + + + V P T++
Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Score = 111 bits (278), Expect = 3e-24
Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)
Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
PG +Y + PED R F P++ +S L DF H+ F L+++
Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366
Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
G L A L + I++ N++ P FT P+ +LE G ++ N+T+
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
+D +D P L+ + + F + Q +T + + Q +DR+ + T +
Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480
Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
+ D G QE+ I I V D NDN T + ++ + V G ++ L D
Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
+ S T VG+ F+ + +G I + ++ + G Y + +Q
Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585
Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T
Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698
Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
S+ TV + + + ND P+ P LP +L V N ++ TD D+
Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753
Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
YS+ GN NN F + N GS T + L ++ DY LV V D + R
Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800
Query: 664 AEALVETGTVTLSIKVI 680
T+TL+IKV+
Sbjct: 801 -------STLTLAIKVL 810
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 122 bits (306), Expect = 1e-27
Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)
Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
T A+N+PP S+ +++ + P FPQ++ S ++EA RV +
Sbjct: 587 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 646
Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
S TY F + TTG+ + LD E+ + T
Sbjct: 647 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 706
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
+ + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L +
Sbjct: 707 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 763
Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D
Sbjct: 764 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 821
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG +
Sbjct: 822 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 880
Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
+ + +D +A Q +I+ V D YG I +T IV+D+ND P K +
Sbjct: 881 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 938
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
MV KGT + + + +D++ P + F P+ + +
Sbjct: 939 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 988
Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
SG+++ +L+ E P+ + + +++ D P ++ V IL E P
Sbjct: 989 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1042
Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
VSE T VG + A + S++YSI +G + F IN TG +
Sbjct: 1043 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1095
Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
+ +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y
Sbjct: 1096 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1155
Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
+ D ++ T++ K T D + S ++R I P F G T +L
Sbjct: 1156 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1215
Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
R Y +K V TDD KA+ LV + + + V P T++
Sbjct: 1216 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1265
Score = 111 bits (278), Expect = 3e-24
Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)
Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
PG +Y + PED R F P++ +S L DF H+ F L+++
Sbjct: 325 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 371
Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
G L A L + I++ N++ P FT P+ +LE G ++ N+T+
Sbjct: 372 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 431
Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
+D +D P L+ + + F + Q +T + + Q +DR+ + T +
Sbjct: 432 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 485
Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
+ D G QE+ I I V D NDN T + ++ + V G ++ L D
Sbjct: 486 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 542
Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
+ S T VG+ F+ + +G I + ++ + G Y + +Q
Sbjct: 543 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 590
Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++
Sbjct: 591 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 649
Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T
Sbjct: 650 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 703
Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
S+ TV + + + ND P+ P LP +L V N ++ TD D+
Sbjct: 704 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 758
Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
YS+ GN NN F + N GS T + L ++ DY LV V D + R
Sbjct: 759 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 805
Query: 664 AEALVETGTVTLSIKVI 680
T+TL+IKV+
Sbjct: 806 -------STLTLAIKVL 815
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
Length = 1539
Score = 122 bits (306), Expect = 1e-27
Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)
Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
T A+N+PP S+ +++ + P FPQ++ S ++EA RV +
Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
S TY F + TTG+ + LD E+ + T
Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
+ + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L +
Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758
Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D
Sbjct: 759 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG +
Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875
Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
+ + +D +A Q +I+ V D YG I +T IV+D+ND P K +
Sbjct: 876 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
MV KGT + + + +D++ P + F P+ + +
Sbjct: 934 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983
Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
SG+++ +L+ E P+ + + +++ D P ++ V IL E P
Sbjct: 984 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037
Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
VSE T VG + A + S++YSI +G + F IN TG +
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090
Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
+ +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y
Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150
Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
+ D ++ T++ K T D + S ++R I P F G T +L
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210
Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
R Y +K V TDD KA+ LV + + + V P T++
Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Score = 111 bits (278), Expect = 3e-24
Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)
Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
PG +Y + PED R F P++ +S L DF H+ F L+++
Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366
Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
G L A L + I++ N++ P FT P+ +LE G ++ N+T+
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
+D +D P L+ + + F + Q +T + + Q +DR+ + T +
Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480
Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
+ D G QE+ I I V D NDN T + ++ + V G ++ L D
Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
+ S T VG+ F+ + +G I + ++ + G Y + +Q
Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585
Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T
Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698
Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
S+ TV + + + ND P+ P LP +L V N ++ TD D+
Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753
Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
YS+ GN NN F + N GS T + L ++ DY LV V D + R
Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800
Query: 664 AEALVETGTVTLSIKVI 680
T+TL+IKV+
Sbjct: 801 -------STLTLAIKVL 810
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 122 bits (306), Expect = 1e-27
Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)
Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
T A+N+PP S+ +++ + P FPQ++ S ++EA RV +
Sbjct: 594 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 653
Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
S TY F + TTG+ + LD E+ + T
Sbjct: 654 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 713
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
+ + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L +
Sbjct: 714 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 770
Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D
Sbjct: 771 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 828
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG +
Sbjct: 829 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 887
Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
+ + +D +A Q +I+ V D YG I +T IV+D+ND P K +
Sbjct: 888 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 945
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
MV KGT + + + +D++ P + F P+ + +
Sbjct: 946 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 995
Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
SG+++ +L+ E P+ + + +++ D P ++ V IL E P
Sbjct: 996 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1049
Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
VSE T VG + A + S++YSI +G + F IN TG +
Sbjct: 1050 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1102
Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
+ +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y
Sbjct: 1103 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1162
Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
+ D ++ T++ K T D + S ++R I P F G T +L
Sbjct: 1163 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1222
Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
R Y +K V TDD KA+ LV + + + V P T++
Sbjct: 1223 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1272
Score = 111 bits (277), Expect = 3e-24
Identities = 146/563 (25%), Positives = 233/563 (41%), Gaps = 97/563 (17%)
Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
PG +Y + PED R F P++ +S L DF H+ F L+++
Sbjct: 325 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 371
Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVAN---------I 258
G L A L + I++ N++ P FT P+ +LE G +++ I
Sbjct: 372 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 431
Query: 259 TAEDPDDEGFPS--------HLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQN 308
A D D E P L + + F + Q +T + + Q +DR+ +
Sbjct: 432 VALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQ 486
Query: 309 PTISLEVLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDL 367
T + + D G QE+ I I V D NDN T + ++ + V G ++ L
Sbjct: 487 QTYTFSITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 543
Query: 368 NKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKY 427
D+ S T VG+ F+ + +G I + ++ + G Y
Sbjct: 544 TAVDADEGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTY 591
Query: 428 TVIIQVQDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQV 483
+ +Q D APP + N VY+ +L P N+ P F + Y ++SE + +
Sbjct: 592 ALTVQAADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 650
Query: 484 RATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN 543
+ATD++ S+ Y+I G VF ++ TG L L +D E+T YIL I A++
Sbjct: 651 QATDRE--GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASD 704
Query: 544 N--EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSS 598
+ TS+ TV + + + ND P+ P LP +L V N ++ TD D+
Sbjct: 705 GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAG 759
Query: 599 PR-SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNL 657
YS+ GN NN F + N GS T + L ++ DY LV V D
Sbjct: 760 INGQVHYSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGA 807
Query: 658 MSDRKKAEALVETGTVTLSIKVI 680
+ R T+TL+IKV+
Sbjct: 808 VHPRH--------STLTLAIKVL 822
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 122 bits (306), Expect = 1e-27
Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)
Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
T A+N+PP S+ +++ + P FPQ++ S ++EA RV +
Sbjct: 560 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 619
Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
S TY F + TTG+ + LD E+ + T
Sbjct: 620 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 679
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
+ + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L +
Sbjct: 680 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 736
Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D
Sbjct: 737 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 794
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG +
Sbjct: 795 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 853
Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
+ + +D +A Q +I+ V D YG I +T IV+D+ND P K +
Sbjct: 854 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 911
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
MV KGT + + + +D++ P + F P+ + +
Sbjct: 912 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 961
Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
SG+++ +L+ E P+ + + +++ D P ++ V IL E P
Sbjct: 962 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1015
Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
VSE T VG + A + S++YSI +G + F IN TG +
Sbjct: 1016 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1068
Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
+ +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y
Sbjct: 1069 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1128
Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
+ D ++ T++ K T D + S ++R I P F G T +L
Sbjct: 1129 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1188
Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
R Y +K V TDD KA+ LV + + + V P T++
Sbjct: 1189 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
Score = 111 bits (278), Expect = 3e-24
Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)
Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
PG +Y + PED R F P++ +S L DF H+ F L+++
Sbjct: 298 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 344
Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
G L A L + I++ N++ P FT P+ +LE G ++ N+T+
Sbjct: 345 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 404
Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
+D +D P L+ + + F + Q +T + + Q +DR+ + T +
Sbjct: 405 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 458
Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
+ D G QE+ I I V D NDN T + ++ + V G ++ L D
Sbjct: 459 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515
Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
+ S T VG+ F+ + +G I + ++ + G Y + +Q
Sbjct: 516 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 563
Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++
Sbjct: 564 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 622
Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T
Sbjct: 623 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 676
Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
S+ TV + + + ND P+ P LP +L V N ++ TD D+
Sbjct: 677 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 731
Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
YS+ GN NN F + N GS T + L ++ DY LV V D + R
Sbjct: 732 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 778
Query: 664 AEALVETGTVTLSIKVI 680
T+TL+IKV+
Sbjct: 779 -------STLTLAIKVL 788
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 122 bits (306), Expect = 1e-27
Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)
Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
T A+N+PP S+ +++ + P FPQ++ S ++EA RV +
Sbjct: 545 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 604
Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
S TY F + TTG+ + LD E+ + T
Sbjct: 605 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 664
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
+ + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L +
Sbjct: 665 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 721
Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D
Sbjct: 722 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 779
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG +
Sbjct: 780 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 838
Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
+ + +D +A Q +I+ V D YG I +T IV+D+ND P K +
Sbjct: 839 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 896
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
MV KGT + + + +D++ P + F P+ + +
Sbjct: 897 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 946
Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
SG+++ +L+ E P+ + + +++ D P ++ V IL E P
Sbjct: 947 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1000
Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
VSE T VG + A + S++YSI +G + F IN TG +
Sbjct: 1001 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1053
Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
+ +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y
Sbjct: 1054 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1113
Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
+ D ++ T++ K T D + S ++R I P F G T +L
Sbjct: 1114 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1173
Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
R Y +K V TDD KA+ LV + + + V P T++
Sbjct: 1174 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223
Score = 111 bits (278), Expect = 3e-24
Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)
Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
PG +Y + PED R F P++ +S L DF H+ F L+++
Sbjct: 283 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 329
Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
G L A L + I++ N++ P FT P+ +LE G ++ N+T+
Sbjct: 330 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 389
Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
+D +D P L+ + + F + Q +T + + Q +DR+ + T +
Sbjct: 390 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 443
Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
+ D G QE+ I I V D NDN T + ++ + V G ++ L D
Sbjct: 444 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 500
Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
+ S T VG+ F+ + +G I + ++ + G Y + +Q
Sbjct: 501 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 548
Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++
Sbjct: 549 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 607
Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T
Sbjct: 608 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 661
Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
S+ TV + + + ND P+ P LP +L V N ++ TD D+
Sbjct: 662 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 716
Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
YS+ GN NN F + N GS T + L ++ DY LV V D + R
Sbjct: 717 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 763
Query: 664 AEALVETGTVTLSIKVI 680
T+TL+IKV+
Sbjct: 764 -------STLTLAIKVL 773
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 122 bits (306), Expect = 1e-27
Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)
Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
T A+N+PP S+ +++ + P FPQ++ S ++EA RV +
Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
S TY F + TTG+ + LD E+ + T
Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
+ + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L +
Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758
Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D
Sbjct: 759 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG +
Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875
Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
+ + +D +A Q +I+ V D YG I +T IV+D+ND P K +
Sbjct: 876 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
MV KGT + + + +D++ P + F P+ + +
Sbjct: 934 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983
Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
SG+++ +L+ E P+ + + +++ D P ++ V IL E P
Sbjct: 984 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037
Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
VSE T VG + A + S++YSI +G + F IN TG +
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090
Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
+ +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y
Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150
Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
+ D ++ T++ K T D + S ++R I P F G T +L
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210
Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
R Y +K V TDD KA+ LV + + + V P T++
Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Score = 111 bits (278), Expect = 3e-24
Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)
Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
PG +Y + PED R F P++ +S L DF H+ F L+++
Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366
Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
G L A L + I++ N++ P FT P+ +LE G ++ N+T+
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
+D +D P L+ + + F + Q +T + + Q +DR+ + T +
Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480
Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
+ D G QE+ I I V D NDN T + ++ + V G ++ L D
Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
+ S T VG+ F+ + +G I + ++ + G Y + +Q
Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585
Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T
Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698
Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
S+ TV + + + ND P+ P LP +L V N ++ TD D+
Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753
Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
YS+ GN NN F + N GS T + L ++ DY LV V D + R
Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800
Query: 664 AEALVETGTVTLSIKVI 680
T+TL+IKV+
Sbjct: 801 -------STLTLAIKVL 810
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
Length = 1957
Score = 122 bits (306), Expect = 1e-27
Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)
Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
T A+N+PP S+ +++ + P FPQ++ S ++EA RV +
Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
S TY F + TTG+ + LD E+ + T
Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
+ + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L +
Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758
Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D
Sbjct: 759 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG +
Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875
Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
+ + +D +A Q +I+ V D YG I +T IV+D+ND P K +
Sbjct: 876 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
MV KGT + + + +D++ P + F P+ + +
Sbjct: 934 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983
Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
SG+++ +L+ E P+ + + +++ D P ++ V IL E P
Sbjct: 984 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037
Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
VSE T VG + A + S++YSI +G + F IN TG +
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090
Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
+ +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y
Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150
Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
+ D ++ T++ K T D + S ++R I P F G T +L
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210
Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
R Y +K V TDD KA+ LV + + + V P T++
Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Score = 111 bits (278), Expect = 3e-24
Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)
Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
PG +Y + PED R F P++ +S L DF H+ F L+++
Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366
Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
G L A L + I++ N++ P FT P+ +LE G ++ N+T+
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
+D +D P L+ + + F + Q +T + + Q +DR+ + T +
Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480
Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
+ D G QE+ I I V D NDN T + ++ + V G ++ L D
Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
+ S T VG+ F+ + +G I + ++ + G Y + +Q
Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585
Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T
Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698
Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
S+ TV + + + ND P+ P LP +L V N ++ TD D+
Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753
Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
YS+ GN NN F + N GS T + L ++ DY LV V D + R
Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800
Query: 664 AEALVETGTVTLSIKVI 680
T+TL+IKV+
Sbjct: 801 -------STLTLAIKVL 810
>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
Length = 1962
Score = 122 bits (306), Expect = 1e-27
Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)
Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
T A+N+PP S+ +++ + P FPQ++ S ++EA RV +
Sbjct: 587 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 646
Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
S TY F + TTG+ + LD E+ + T
Sbjct: 647 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 706
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
+ + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L +
Sbjct: 707 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 763
Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D
Sbjct: 764 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 821
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG +
Sbjct: 822 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 880
Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
+ + +D +A Q +I+ V D YG I +T IV+D+ND P K +
Sbjct: 881 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 938
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
MV KGT + + + +D++ P + F P+ + +
Sbjct: 939 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 988
Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
SG+++ +L+ E P+ + + +++ D P ++ V IL E P
Sbjct: 989 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1042
Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
VSE T VG + A + S++YSI +G + F IN TG +
Sbjct: 1043 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1095
Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
+ +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y
Sbjct: 1096 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1155
Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
+ D ++ T++ K T D + S ++R I P F G T +L
Sbjct: 1156 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1215
Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
R Y +K V TDD KA+ LV + + + V P T++
Sbjct: 1216 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1265
Score = 111 bits (278), Expect = 3e-24
Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)
Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
PG +Y + PED R F P++ +S L DF H+ F L+++
Sbjct: 325 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 371
Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
G L A L + I++ N++ P FT P+ +LE G ++ N+T+
Sbjct: 372 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 431
Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
+D +D P L+ + + F + Q +T + + Q +DR+ + T +
Sbjct: 432 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 485
Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
+ D G QE+ I I V D NDN T + ++ + V G ++ L D
Sbjct: 486 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 542
Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
+ S T VG+ F+ + +G I + ++ + G Y + +Q
Sbjct: 543 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 590
Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++
Sbjct: 591 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 649
Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T
Sbjct: 650 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 703
Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
S+ TV + + + ND P+ P LP +L V N ++ TD D+
Sbjct: 704 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 758
Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
YS+ GN NN F + N GS T + L ++ DY LV V D + R
Sbjct: 759 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 805
Query: 664 AEALVETGTVTLSIKVI 680
T+TL+IKV+
Sbjct: 806 -------STLTLAIKVL 815
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 122 bits (306), Expect = 1e-27
Identities = 161/653 (24%), Positives = 269/653 (41%), Gaps = 81/653 (12%)
Query: 5 IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVN 64
+I++ L G G AT + EN+PPGT + V P
Sbjct: 2053 VIIVGLQGEAERGPRFPRASSEAT--IRENAPPGTPI-------------VSPRAVHAGG 2097
Query: 65 SN-PLTEAFRVNWLSGTYFEVVTTGM------EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
+N P+T + GT+ +TG E LDFE P + + + G
Sbjct: 2098 TNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRL--RLVLQAESGGAFAFT 2155
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVE-RANPGFIYQVEAFDPEDTSRNIPLSYFLI 175
VLT+ + D N+ P+F L ++ E R G + QVEA D + S +SY L
Sbjct: 2156 VLTLTLQDANDNAPRF---LRPHYVAFLPESRPLEGPLLQVEADDLDQGSGG-QISYSLA 2211
Query: 176 SPPKSFRM----SANGTLFSTTELDFEA-GHRSFHLIVEVRDSGGLKASTELQVNIVNLN 230
+ + + GT+ +T LD E L+ R S L S L V +++ N
Sbjct: 2212 ASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTN 2271
Query: 231 DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTG 290
D P P + V E+ G+ +A +T D D ++L S + F + + G
Sbjct: 2272 DNRPTIPQPWEL-RVSEDALLGSEIAQVTGNDVDSGPVLWYVL-SPSGPQDPFSVGRYGG 2329
Query: 291 TIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTF 350
+ + +D Q L++L D P+ G+ N +T +VEDVNDN + +
Sbjct: 2330 RVSLTGPLD-----FEQCDRYQLQLLAHDGPHEGRAN---LTVLVEDVNDNAPAFSQSLY 2381
Query: 351 SIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLI 410
+M+ E T G+ +L ++ D DS A N ++ + S F DP ++
Sbjct: 2382 QVMLLEHTPPGSAILSVS--ATDRDSGA-NGHISYHLAS---PADGFSVDPNNGTLFTIV 2435
Query: 411 GDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDV 470
G + + + A V+++ +D P V++ +N+ F Y V
Sbjct: 2436 GTVALGHDGSGAV----DVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAV 2491
Query: 471 SERRPARTRVGQVRATDKDLPQS--SLLYSISTGGASLQYPNVFWINPKTGE-------- 520
+E P + + + ATD D +S ++ YSI +G + VF + P+ E
Sbjct: 2492 TEDLPPGSTLLTLEATDADGSRSHAAVDYSIISG----NWGRVFQLEPRLAEAGESAGPG 2547
Query: 521 ------LQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNSY 571
L L+ +D E+ Y L + A + +S V VTV +L+ ND P+ T SY
Sbjct: 2548 PRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASY 2607
Query: 572 FLALPVDLKVGTNIQNFKLTCTDLDSSPRSF-RYSIGPGNVNNHFTFSPNAGS 623
+ +P D VG + + +D D P R+++ G+ + F ++G+
Sbjct: 2608 RVTVPEDTPVGAEL--LHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGT 2658
Score = 121 bits (304), Expect = 3e-27
Identities = 149/543 (27%), Positives = 232/543 (42%), Gaps = 57/543 (10%)
Query: 119 LTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176
LTV V DVN+ P F +L + + ++E PG I V A D D+ N +SY L S
Sbjct: 2362 LTVLVEDVNDNAPAFSQSLYQ---VMLLEHTPPGSAILSVSATD-RDSGANGHISYHLAS 2417
Query: 177 PPKSFRMSAN-GTLFS---TTELDFEAGHRSFHLIVEVRDSG--GLKASTELQVNIVNLN 230
P F + N GTLF+ T L + G + +++E RD G G A + V + + N
Sbjct: 2418 PADGFSVDPNNGTLFTIVGTVALGHD-GSGAVDVVLEARDHGAPGRAARATVHVQLQDQN 2476
Query: 231 DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS--KYFMIN-- 286
D P FT V E+L PG+ + + A D D + + YSI + + + F +
Sbjct: 2477 DHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPR 2536
Query: 287 ------------QLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFI 334
+ G + + + +D ++ L Q +L V DR Q + + +T
Sbjct: 2537 LAEAGESAGPGPRALGCLVLLEPLDFES--LTQ---YNLTVAAADRGQPPQSSVVPVTVT 2591
Query: 335 VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSG 394
V DVNDNP + ++ + VPE T G LL + D P+ FT+ SG SG
Sbjct: 2592 VLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEA---SDADPGPHGLVRFTVSSGDPSG 2648
Query: 395 SRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPE 454
L + SG + L LD E + ++ +++Q D A ++ V I
Sbjct: 2649 LFELDE--SSGTLRLAHALDCETQA------RHQLVVQAADPAGAHFA-LAPVTIEVQDV 2699
Query: 455 NEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQ-SSLLYSISTGGASLQYPNVFW 513
N+ F V+E +P T V + A D D L YS+ G + F
Sbjct: 2700 NDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFA 2759
Query: 514 INPKTGELQLVTKVDCETTPIYILRIQATNNEDTS-SVTVTVNILEENDEKPICTPNSYF 572
+N TGEL+ D E T + L + A + + S SVTV+V + E++ P+ ++
Sbjct: 2760 LNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFH 2819
Query: 573 LALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTS 632
+P + G ++ + + T D + YS+ T SP G N T L
Sbjct: 2820 FQVPEGARRGHSLGHVQATDED-GGADGLVLYSLA--------TSSPYFGINQTTGALYL 2870
Query: 633 RFD 635
R D
Sbjct: 2871 RVD 2873
Score = 108 bits (269), Expect = 3e-23
Identities = 167/672 (24%), Positives = 263/672 (39%), Gaps = 87/672 (12%)
Query: 33 ENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQL 92
EN+PPGTS+ + L A+ P + Q+ +E+F ++ +G V T + L
Sbjct: 1660 ENNPPGTSL----LTLRAT-DPDVGANGQVTYGGVSSESFSLDPDTG-----VLTTLRAL 1709
Query: 93 DFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGF 152
D E I +L +Y +D L +TV+V +E + L L + E +P
Sbjct: 1710 DREEQEEI-NLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT 1768
Query: 153 IYQVEAFDPEDTSRNIPLSYFLIS--PPKSFRMS-ANGTLFSTTELDFEAGHRSFHLIVE 209
+ + A DP D N L Y ++ P +F + A+G + LD E +F L +E
Sbjct: 1769 LTMLRASDP-DVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREV-EPAFQLRIE 1826
Query: 210 VRDSG--GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEG 267
RD G L A+ L V +++ ND P F P V E++ GT++ + A DP D G
Sbjct: 1827 ARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDP-DAG 1885
Query: 268 FPSHLLYSI-TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQ- 325
H+ Y + + F++ +G ++ A +DR+ Q P+ + V D G
Sbjct: 1886 ANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDRE-----QCPSYTFSVSAVDGAAAGPL 1940
Query: 326 ENRIQITFIVEDVNDNPATCQKFTFSIMVPE-RTAKGTLLLDLNKFCFDDDSEAPN---- 380
+ +T V DVND+ T + +P + T L L +D N
Sbjct: 1941 STTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASIL 2000
Query: 381 NRFNFTMPSGVGSGS-----RFLQDPAGSG---KIVLIGDLDYENPSNLAAGNKYTVIIQ 432
R T P G S R + P G +++ I D P+ A G +I+
Sbjct: 2001 YRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATG---VIIVG 2057
Query: 433 VQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQ 492
+Q E E F R S + E P T + RA
Sbjct: 2058 LQG------------------EAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTN 2099
Query: 493 SSLLYSISTGGASLQYPNVFWINPKTGELQL--VTKVDCETTPIYILRIQATNNEDTSSV 550
+ YSI +G F I P TG + + +D E +P L +QA + +
Sbjct: 2100 GPITYSILSGNEK----GTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT 2155
Query: 551 TVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLD-SSPRSFRYSIGPG 609
+T+ + + ND P Y LP + + ++ DLD S YS+
Sbjct: 2156 VLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPL--LQVEADDLDQGSGGQISYSLAAS 2213
Query: 610 N-VNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALV 668
F P G+ T +L +IW LV LM+ + + ALV
Sbjct: 2214 QPARGLFHVDPTTGTITTTAILDR---------EIWAETRLV------LMATDRGSPALV 2258
Query: 669 ETGTVTLSIKVI 680
G+ TL++ VI
Sbjct: 2259 --GSATLTVMVI 2268
Score = 106 bits (264), Expect = 1e-22
Identities = 142/560 (25%), Positives = 225/560 (40%), Gaps = 52/560 (9%)
Query: 33 ENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQL 92
EN PG +++ F + P +++ P A R++ +G + L
Sbjct: 1447 ENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-----SAPRGL 1501
Query: 93 DFETGPNIFDLQIYVKDEVGVTDLQVLTVQ----VTDVNE-PPQFQGNLAEGLHLYIVER 147
D ET P + L + + V VTD N+ P F A + + E
Sbjct: 1502 DRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF----ASPSRVRLPED 1557
Query: 148 ANPG-FIYQVEAFDPEDTSRNIPLSYFLISPPKS-FRM-SANGTLFSTTELDFEAGHRSF 204
PG V A DP D +SY L S FR+ S+ G L LD E R+
Sbjct: 1558 QPPGPAALHVVARDP-DLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDRE--QRAE 1614
Query: 205 HLIVEVRDSGGL---KASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAE 261
H++ V G A+ L V++ ++NDE P F + E PGT + + A
Sbjct: 1615 HVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRAT 1674
Query: 262 DPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRP 321
DP D G + Y + S+ F ++ TG + + +DR+ E I+L V +DR
Sbjct: 1675 DP-DVGANGQVTYGGVS-SESFSLDPDTGVLTTLRALDREEQE-----EINLTVYAQDRG 1727
Query: 322 YGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNN 381
Q + + VED ND+ T S+ VPE TL + D N
Sbjct: 1728 SPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM----LRASDPDVGANG 1783
Query: 382 RFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYY 441
+ + + G SG+ F+ D A SG+ + LD E + + I+ +D P
Sbjct: 1784 QLQYRILDGDPSGA-FVLDLA-SGEFGTMRPLDRE------VEPAFQLRIEARDGGQPAL 1835
Query: 442 KNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL-PQSSLLYSIS 500
+ + + N+ F P+Y +V E PA T + Q++A D D + Y +
Sbjct: 1836 SATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLG 1895
Query: 501 TGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNED----TSSVTVTVNI 556
G A F + P +GEL+ +D E P Y + A + +++V+VT+ +
Sbjct: 1896 AGTA-----GAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITV 1950
Query: 557 LEENDEKPICTPNSYFLALP 576
+ ND P + L LP
Sbjct: 1951 RDVNDHAPTFPTSPLRLRLP 1970
Score = 87.0 bits (214), Expect = 7e-17
Identities = 136/622 (21%), Positives = 253/622 (40%), Gaps = 64/622 (10%)
Query: 31 VAENSPPGTSVHK-FSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGM 89
VAEN PPGTSV + F+ + + + Q ++ + ++AFR++ +G + T
Sbjct: 1114 VAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSED--SKAFRIHPQTGEVTTLQTLDR 1171
Query: 90 EQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT--DVNEPP----QFQGNLAEGLHLY 143
EQ + + L + V+D TV V D+N+ Q G GL +
Sbjct: 1172 EQ------QSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQ 1225
Query: 144 IVERANPG-FIYQVEAFDPEDTSRNIPLSYFLISP-PKSFRMSANGTLFSTTELDFEAGH 201
+ +R PG + ++A DP D N + Y L P + F + + T A
Sbjct: 1226 VPDRVPPGTLVTTLQAKDP-DEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAER 1284
Query: 202 RSFHLIVEVRDSGGLKASTELQVNI------------VNLNDEVPRFTSP-TRVYTVLEE 248
+ L + D G S LQ+ + +L + P P T E
Sbjct: 1285 PHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEG 1344
Query: 249 LSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQN 308
L PG+++ ++ A +P G ++ L F ++ +G + +A+ +D +AG +
Sbjct: 1345 LRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRA 1404
Query: 309 PTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLN 368
T+ E P G +++ V+D N++ + ++ +PE G L
Sbjct: 1405 LTVRAE-----GPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFR 1459
Query: 369 KFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYT 428
D D PN+ + + D A +G + LD E L
Sbjct: 1460 --ASDADGPGPNSDVRYRLLRQEPPVPALRLD-ARTGALSAPRGLDRETTPAL------L 1510
Query: 429 VIIQVQD---VAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRA 485
++++ D A V + + EN+ +F PS V + E +P V A
Sbjct: 1511 LLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRV-RLPEDQPPGPAALHVVA 1569
Query: 486 TDKDLPQSS-LLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN 544
D DL +++ + Y +++GG F ++ TG L +V +D E ++L + A+++
Sbjct: 1570 RDPDLGEAARVSYRLASGG-----DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDH 1624
Query: 545 ED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS 601
+++ +TV++ + NDE P Y + L + GT++ + T D+ ++ +
Sbjct: 1625 GSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQ- 1683
Query: 602 FRYSIGPGNVNNH-FTFSPNAG 622
+ G V++ F+ P+ G
Sbjct: 1684 ----VTYGGVSSESFSLDPDTG 1701
Score = 84.3 bits (207), Expect = 4e-16
Identities = 142/634 (22%), Positives = 237/634 (37%), Gaps = 70/634 (11%)
Query: 68 LTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQ---VLTVQVT 124
L +W S + T LD+E P I V + G+ L ++V +
Sbjct: 512 LAPGAHTHWFSIDPTSGIITTAASLDYELEPQ--PQLIVVATDGGLPPLASSATVSVALQ 569
Query: 125 DVNE-PPQFQGNLAEGLHLYIVERANPGFIY-QVEAFDPEDTSRNIPLSYFLI------- 175
DVN+ PQFQ + + E PG + QV A D + + LSY L
Sbjct: 570 DVNDNEPQFQRTF---YNASLPEGTQPGTCFLQVTATDADSGPFGL-LSYSLGAGLGSSG 625
Query: 176 SPPKSFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVP 234
SPP FR+ A+ G + +T LD + G SF V D GGLK+ ++V + + ND P
Sbjct: 626 SPP--FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPP 683
Query: 235 RFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSK--YFMINQLTGTI 292
+F ++ + PGT V + A DP D+G L Y I + F +++ +G +
Sbjct: 684 QFYPREYAASISAQSPPGTAVLRLRAHDP-DQGSHGRLSYHILAGNSPPLFTLDEQSGLL 742
Query: 293 QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352
VA + R R N + LE+ +D E ++ + P ++ +
Sbjct: 743 TVAWPLAR-----RANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVF 797
Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412
VPE A GT + + P T+ G A SG + +
Sbjct: 798 SVPEDVAPGTSVGIVQA------HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRP 851
Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472
LD E G + ++ PP + V +L N+ F P +
Sbjct: 852 LDRE-----LLGPVLELEVRAGSGVPPAFA-VARVRVLLDDVNDNSPAFPAPEDTVLLPP 905
Query: 473 RRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531
T + +RA D D S + +++ GG F ++P TG ++L+ +
Sbjct: 906 NTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGG-----GAFTVDPTTGHVRLMRPLGPSG 960
Query: 532 TPIYILRIQATNNEDTSSVT-----VTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586
P + L ++A + + V V + P +Y + LP GT +
Sbjct: 961 GPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQV- 1019
Query: 587 NFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDY 646
++ D P Y + ++ F P +G R L +++
Sbjct: 1020 -LQVQAQAPDGGP--ITYHLAAEGASSPFGLEPQSGWLWVRAALDRE------AQELYIL 1070
Query: 647 KLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVI 680
K++ KAE +TGT T+ + ++
Sbjct: 1071 KVMAV--------SGSKAELGQQTGTATVRVSIL 1096
Score = 83.2 bits (204), Expect = 1e-15
Identities = 115/485 (23%), Positives = 188/485 (38%), Gaps = 58/485 (11%)
Query: 153 IYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSA---NGTLFSTTELDFEAGHRSFHLIVE 209
+ QV+A P+ P++Y L + S +G L+ LD EA ++
Sbjct: 1019 VLQVQAQAPDGG----PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMA 1074
Query: 210 VRDS----GGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDD 265
V S G + ++V+I+N N+ PR + V E PGT V + A D D
Sbjct: 1075 VSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDS 1134
Query: 266 --EGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYG 323
G ++ L ++ SK F I+ TG + Q +DR+ Q + L V V+D
Sbjct: 1135 GPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDRE-----QQSSYQLLVQVQDGGSP 1189
Query: 324 GQENRIQITFIVEDVNDNPATCQKFT------FSIMVPERTAKGTLLLDLNKFCFDDDSE 377
+ + V D+NDN T + + I VP+R GTL+ L D E
Sbjct: 1190 PRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQA---KDPDE 1246
Query: 378 APNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVA 437
N +T+ G GS SG+++ P A Y + + D
Sbjct: 1247 GENGTILYTL---TGPGSELFSLHPHSGELLTAA------PLIRAERPHYVLTLSAHDQG 1297
Query: 438 PPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD-LPQSSLL 496
P ++ + + P + + P D++ER PA + T + L SLL
Sbjct: 1298 SPPRSASLQLLVQVLPSAR---LAEPPP---DLAERDPAAPVPVVLTVTAAEGLRPGSLL 1351
Query: 497 YSIS----TGGASLQYPNV--------FWINPKTGELQLVTKVDCETTPIY---ILRIQA 541
S++ G +L Y V F ++ +G L L +D E P + +R +
Sbjct: 1352 GSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEG 1411
Query: 542 TNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS 601
+ V V + +EN+ P + LALP + + G + F+ + D
Sbjct: 1412 PGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSD 1471
Query: 602 FRYSI 606
RY +
Sbjct: 1472 VRYRL 1476
Score = 82.4 bits (202), Expect = 2e-15
Identities = 163/640 (25%), Positives = 246/640 (38%), Gaps = 81/640 (12%)
Query: 5 IILLALLGAM---SGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQ 61
++LL LLGA + G+A L L + E P GT + S L A + + F
Sbjct: 27 LLLLLLLGAGVPGAWGQAGSLDL-----QIDEEQPAGTLIGDISAGLPAGTAAPLMYFIS 81
Query: 62 IVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTV 121
+ + ++ SG EQ D + D V +TV
Sbjct: 82 AQEGSGVGTDLAIDEHSGVVRTARVLDREQRDR------YRFTAVTPDGATVE----VTV 131
Query: 122 QVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPP-- 178
+V D+N+ P F A L + E G Y +E D R Y L
Sbjct: 132 RVADINDHAPAFPQARAA---LQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAG 188
Query: 179 KSFRMSA----NGT----LFSTTELDFEAGHRSFHLI-VEVRDSGG--LKASTELQVNIV 227
++FR+ +GT L T ELD E +RS +++ +E D G +A L V ++
Sbjct: 189 ETFRLETRPGPDGTPVPELVVTGELDRE--NRSHYMLQLEAYDGGSPPRRAQALLDVTLL 246
Query: 228 NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY----F 283
++ND P F V E L+PG+ V + A D D G + Y I F
Sbjct: 247 DINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDA-DAGVNGAVTYEINRRQSEGDGPF 305
Query: 284 MINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPA 343
I+ TG +Q+ + +D Q L V +D + +T V D NDN
Sbjct: 306 SIDAHTGLLQLERPLD-----FEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQP 360
Query: 344 TCQKFTFSI----MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQ 399
+ S V E G L+ ++ DD A N ++ G G + Q
Sbjct: 361 SMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFA---HVNVSLEGGEGHFALSTQ 417
Query: 400 DPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDV-APPYYKNNVYVYILTSPENEFP 458
D + + LD E + Y + + D +PP +V +T + P
Sbjct: 418 DSV-IYLVCVARRLDREE------RDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAP 470
Query: 459 LIFDRPSYVFDVSERRPARTRVGQ--VRATDKDLPQSS---LLYSISTGGASLQYPNVFW 513
FDR Y E P G VR T +D Q + + YS++ G + + F
Sbjct: 471 -AFDRQLY---RPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGA----HTHWFS 522
Query: 514 INPKTGELQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNS 570
I+P +G + +D E P L + AT+ SS TV+V + + ND +P
Sbjct: 523 IDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTF 582
Query: 571 YFLALPVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGPG 609
Y +LP + GT ++T TD DS P YS+G G
Sbjct: 583 YNASLPEGTQPGTCF--LQVTATDADSGPFGLLSYSLGAG 620
Score = 60.8 bits (146), Expect = 5e-09
Identities = 59/195 (30%), Positives = 89/195 (45%), Gaps = 15/195 (7%)
Query: 116 LQVLTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFL 174
L +T++V DVN+ P F NL L + E PG + D L Y L
Sbjct: 2689 LAPVTIEVQDVNDHGPAFPLNL---LSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSL 2745
Query: 175 ISPP------KSFRM-SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIV 227
+ ++F + S+ G L + D+E SF L+V D+G L AS + V +
Sbjct: 2746 LEAGPGPEGREAFALNSSTGELRARVPFDYEHTE-SFRLLVGAADAGNLSASVTVSVLVT 2804
Query: 228 NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQ 287
++ P F +P + V E G + ++ A D +D G +LYS+ T S YF INQ
Sbjct: 2805 GEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATD-EDGGADGLVLYSLATSSPYFGINQ 2863
Query: 288 LTGTIQVAQRIDRDA 302
TG + + R+D A
Sbjct: 2864 TTGALYL--RVDSRA 2876
Score = 47.0 bits (110), Expect = 8e-05
Identities = 73/288 (25%), Positives = 112/288 (38%), Gaps = 30/288 (10%)
Query: 89 MEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT--DVNE-PPQFQGNLAEGLHLYIV 145
+E LDFE+ ++L + D V+ V VT DVN+ PP F + +
Sbjct: 2557 LEPLDFESLTQ-YNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFT---RASYRVTVP 2612
Query: 146 ERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS---PPKSFRMS-ANGTLFSTTELDFEAG 200
E G + VEA D + L F +S P F + ++GTL LD E
Sbjct: 2613 EDTPVGAELLHVEASDADPGPHG--LVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQ 2670
Query: 201 HRSFHLIVEVRDSGGLK-ASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANIT 259
R L+V+ D G A + + + ++ND P F +V E PGT+V +
Sbjct: 2671 ARH-QLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLH 2729
Query: 260 AEDPDDEGFPSHLLYSITTVS------KYFMINQLTGTIQVAQRIDRDAGELRQNPTISL 313
A D D F L YS+ + F +N TG ++ D + E S
Sbjct: 2730 AIDGDAGAF-GRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTE-------SF 2781
Query: 314 EVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361
+LV G + ++ +V ++ F VPE +G
Sbjct: 2782 RLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRG 2829
Score = 45.1 bits (105), Expect = 3e-04
Identities = 92/432 (21%), Positives = 161/432 (37%), Gaps = 55/432 (12%)
Query: 218 ASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDE--GFPSHLLYS 275
A+ E+ V + ++ND P F V E + GT A D D G + L S
Sbjct: 125 ATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYAL-S 183
Query: 276 ITTVSKYFMINQLTGT-------IQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENR 328
+ F + G + V +DR E R + + LE P +
Sbjct: 184 GDGAGETFRLETRPGPDGTPVPELVVTGELDR---ENRSHYMLQLEAYDGGSPPRRAQAL 240
Query: 329 IQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAP-NNRFNFTM 387
+ +T + D+ND+ + + +V E A G+ +L + F D++A N + +
Sbjct: 241 LDVTLL--DINDHAPAFNQSRYHAVVSESLAPGSPVLQV----FASDADAGVNGAVTYEI 294
Query: 388 PSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQD--VAPPYYKNNV 445
G A +G + L LD+E + +++Q +D P V
Sbjct: 295 NRRQSEGDGPFSIDAHTGLLQLERPLDFEQR------RVHELVVQARDGGAHPELGSAFV 348
Query: 446 YVYILTSPENE--FPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGG 503
V++ + +N+ +IF VSE P V ++ +D D + + GG
Sbjct: 349 TVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGG 408
Query: 504 ASLQYPNVFWINPKTGELQLVT---KVDCETTPIYILRIQATNNEDT---SSVTVTVNIL 557
F ++ + + LV ++D E Y LR+ AT++ + +++
Sbjct: 409 EGH-----FALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVT 463
Query: 558 EENDEKPICTPNSYF------LALPVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGPGN 610
+ ND P Y +ALP V ++T D D YS+ PG
Sbjct: 464 DVNDNAPAFDRQLYRPEPLPEVALPGSFVV-------RVTARDPDQGTNGQVTYSLAPGA 516
Query: 611 VNNHFTFSPNAG 622
+ F+ P +G
Sbjct: 517 HTHWFSIDPTSG 528
>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
Length = 1886
Score = 120 bits (302), Expect = 4e-27
Identities = 173/717 (24%), Positives = 293/717 (40%), Gaps = 85/717 (11%)
Query: 3 EAIILLALLGAMSG--GEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP 60
+++I L + A G GE + IL+ A G+ F + + L + PG
Sbjct: 526 DSVIQLTAVDADEGSNGEITYEILVGAQGD-------------FIINKTTGLITIAPGVE 572
Query: 61 QIVNSN-PLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVL 119
IV LT N + T + LD E+ + T +
Sbjct: 573 MIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV 632
Query: 120 TVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPP 178
+ VTDVN+ P F L L +VE F+ QV+A DP D N + Y L +
Sbjct: 633 NIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGNFN 689
Query: 179 KSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEVPR 235
FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D P
Sbjct: 690 NLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV 747
Query: 236 FTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVA 295
FT+ T V E L GT + I A+D D S+ + S V +F ++ TG + +
Sbjct: 748 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELSLL 806
Query: 296 QRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSIMV 354
+ +D +A Q +I+ V D YG I +T IV+D+ND P K + MV
Sbjct: 807 RSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 864
Query: 355 PERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPAGS 404
KGT + + + +D++ P + F P+ + + S
Sbjct: 865 APDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEEDS 914
Query: 405 GKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP 464
G+++ +L+ E P+ + + +++ D P ++ V IL E P
Sbjct: 915 GRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEE 968
Query: 465 SYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLV 524
VSE T VG + A + S++YSI +G + F IN TG + +
Sbjct: 969 YRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIYVN 1021
Query: 525 TKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYFLA 574
+D ET Y+LR+QA + E +++ V + I +EN+ P+ Y
Sbjct: 1022 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1081
Query: 575 LPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL-T 631
+ D ++ T++ K T D + S ++R I P F G T +L
Sbjct: 1082 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHN 1141
Query: 632 SRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
R Y +K V TDD KA+ LV + + + V P T++
Sbjct: 1142 MRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189
Score = 84.3 bits (207), Expect = 4e-16
Identities = 129/560 (23%), Positives = 220/560 (39%), Gaps = 105/560 (18%)
Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
PG +Y + PED R F P++ +S L DF H+ F L+++
Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366
Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
G L A L + I++ N++ P FT P+ +LE G ++ N+T+
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
+D +D P L+ + + F + Q +T + + Q +DR+ + T +
Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480
Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
+ D G QE+ I I V D NDN T + ++ + V G ++ L D
Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
+ S T VG+ F+ + +G I + ++ + G Y + +Q
Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585
Query: 434 QDVAPPYYKN---------------NVYVYILTSPE------------------NEFPLI 460
D APP ++ + Y+ I+T+ + N+ +
Sbjct: 586 ADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 645
Query: 461 FD--RPSYVFDVSERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPK 517
FD P + V E A VGQV+ATD D + YS+ + N+F I
Sbjct: 646 FDPYLPRNLSVVEEE--ANAFVGQVKATDPDAGINGQVHYSLG------NFNNLFRIT-S 696
Query: 518 TGELQLVTKVDCETTPIYILRIQATN---NEDTSSVTVTVNILEENDEKPICTPNSYFLA 574
G + K++ E Y L + AT+ + S++T+ + +L+ +D P+ T ++Y +
Sbjct: 697 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 756
Query: 575 LPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRF 634
+ +L GT I + DL + + Y I V + F P G L L
Sbjct: 757 VEENLPAGTTILQIEAKDVDLGA---NVSYRIRSPEVKHFFALHPFTG----ELSLLRSL 809
Query: 635 DYAGGFDKIWDYKLLVYVTD 654
DY D+ LV D
Sbjct: 810 DYEAFPDQEASITFLVEAFD 829
Score = 66.6 bits (161), Expect = 1e-10
Identities = 154/693 (22%), Positives = 254/693 (36%), Gaps = 113/693 (16%)
Query: 101 FDLQIYVKDEVG--VTDLQVLTVQVTDVNEP------PQFQGNLAEGLHL--YIVERANP 150
FDL I + + G + L +++ D N P +QG + E + I + N
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 151 GFIYQVEAFDPE-DTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
++ A D + + +++ L FL F ++ G T L
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 210 VRDSGGLKASTELQVNI--VNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEG 267
+ G++ S + VNI ++ ND P F + V ++ PG V +TA D DEG
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA-DEG 539
Query: 268 FPSHLLYSITTVSK-YFMINQLTGTIQVAQRI---------------------DRDAGEL 305
+ Y I ++ F+IN+ TG I +A + +R G L
Sbjct: 540 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGIL 599
Query: 306 RQNPTISLE-----VLV----KDRPYGGQENRIQITFIVEDVNDN-PATCQKFTFSIMVP 355
+ E +L+ RP G + I +V DVNDN P ++ V
Sbjct: 600 TLGKALDRESTDRYILIITASDGRPDGTSTATVNI--VVTDVNDNAPVFDPYLPRNLSVV 657
Query: 356 ERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDY 415
E A N F + P+ N + +G+ + +I G +
Sbjct: 658 EEEA--------NAFVGQVKATDPDAGINGQVHYSLGNFNNLF-------RITSNGSIYT 702
Query: 416 ENPSNLAAGNKYTVIIQVQD--VAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473
N + Y +++ D V P + + + +L +N +F +Y V E
Sbjct: 703 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS--PVFTNSTYTVLVEEN 760
Query: 474 RPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTP 533
PA T + Q+ A D DL +++ Y I S + + F ++P TGEL L+ +D E P
Sbjct: 761 LPAGTTILQIEAKDVDL-GANVSYRI----RSPEVKHFFALHPFTGELSLLRSLDYEAFP 815
Query: 534 -------IYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586
+ TVTV + + ND P+ + Y + D GT I
Sbjct: 816 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 875
Query: 587 NFKLTCTDLDSSPRS-FRYSIG------PGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGG 639
D P S RY + P ++ F ++G +TR+ L
Sbjct: 876 TVYAEDADPPGLPASRVRYRVDDVQFPYPASI---FEVEEDSGRVITRVNLNE------- 925
Query: 640 FDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQV 699
+ +KL+V DD V + + T+ I V+ HP I PR T +
Sbjct: 926 -EPTTIFKLVVVAFDDG---------EPVMSSSATVKILVL-HPGEI------PRFTQEE 968
Query: 700 LRKNVYSPSAWYVPFVITLGSILLLGLLVYLVV 732
R S A V + + + +VY +V
Sbjct: 969 YRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1001
Score = 50.4 bits (119), Expect = 7e-06
Identities = 72/294 (24%), Positives = 114/294 (38%), Gaps = 45/294 (15%)
Query: 330 QITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD----DDSEAPNNRFNF 385
++ +V D NDN T + ++ V E T GT + F D D + PN + +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDGPNGQIEY 189
Query: 386 TM---PSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYK 442
+ P S F +G IVL L+YE+ + +Y VIIQ D A +
Sbjct: 190 VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKT------RYFVIIQANDRAQNLNE 243
Query: 443 NNVYVYILT----SPENEFPLIFD----------RP-SYVFDVSERR-----------PA 476
LT ++ P+ RP +Y + E R P
Sbjct: 244 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 303
Query: 477 RTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYI 536
+ Q R + +LYSI G YP F ++P+T EL L+ V+ + +
Sbjct: 304 IQAIDQDRNIQPPSDRPGILYSILVGTPE-DYPRFFHMHPRTAELSLLEPVNRDFHQKFD 362
Query: 537 LRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQN 587
L I+A + + + + IL+EN++ P T SY + VG I +
Sbjct: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISD 416
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 119 bits (298), Expect = 1e-26
Identities = 153/600 (25%), Positives = 254/600 (42%), Gaps = 38/600 (6%)
Query: 29 GNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTG 88
GNV E+ PPG V S + I NP F + + + V
Sbjct: 2931 GNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGR-FALGLVQSEWKVYVKRP 2989
Query: 89 MEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERA 148
+++ + +I+ L I D + VT V V V+DVN+ +A L +
Sbjct: 2990 LDREE----QDIYFLNITATDGLFVTQAMV-EVSVSDVNDNSPVCDQVAYTALLPEDIPS 3044
Query: 149 NPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS--FRMSANGTLFSTTELDFEAGHRSFHL 206
N I +V A D D N + Y L S F +G L + LD E + L
Sbjct: 3045 NK-IILKVSAKDA-DIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRER-IPVYSL 3101
Query: 207 IVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDE 266
+ + D GG + + + + ++ND P F+S V E + ++ + A DPD
Sbjct: 3102 MAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDI- 3160
Query: 267 GFPSHLLYSIT-TVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQ 325
G ++YS+ + F I+ +G I + Q +DR+ Q + ++ V D+ G
Sbjct: 3161 GINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDRE-----QQSSYNISVRATDQSPGQS 3215
Query: 326 ENRIQ-ITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFN 384
+ + +T V D+NDNP ++ + + VPE T+ GT +L + F D N
Sbjct: 3216 LSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAV--FATSKDI-GTNAEIT 3272
Query: 385 FTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNN 444
+ + SG G +F +P +G I + LDYE ++ ++++ +D P
Sbjct: 3273 YLIRSGNEQG-KFKINPK-TGGISVSEVLDYE------LCKRFYLVVEAKDGGTPALSAV 3324
Query: 445 VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL-PQSSLLYSISTGG 503
V I + N+ P F + Y +SE V + A D D P + +SI G
Sbjct: 3325 ATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGD 3384
Query: 504 ASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEEN 560
N F ++P G +++ K+D E Y L +QA ++ +S+ TV ++I + N
Sbjct: 3385 RD----NEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVN 3440
Query: 561 DEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPN 620
D P+ TP +Y + + VGT+I +T D + F +SI GN F P+
Sbjct: 3441 DNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH 3500
Score = 118 bits (296), Expect = 2e-26
Identities = 112/447 (25%), Positives = 204/447 (45%), Gaps = 37/447 (8%)
Query: 187 GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVL 246
GT+ LD E +++ VEV D + A T++ + +++ ND P F+ P T+
Sbjct: 1413 GTIVIAKPLDAEQ-RSIYNMSVEVTDGTNV-AVTQVFIKVLDNNDNGPEFSQPNYDVTIS 1470
Query: 247 EELSPGTIVANITAEDPDDEGFPSHLLY-SITTVS-KYFMINQLTGTIQVAQRIDRDAGE 304
E++ P T + I A D D++ S+ ++ SI ++S + F I+ TG + A+R+D +A +
Sbjct: 1471 EDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQD 1530
Query: 305 LRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLL 364
L ++V+D+ + + N ++ VED ND+ + V E A G+ +
Sbjct: 1531 KH-----ILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAV 1585
Query: 365 LDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAG 424
L + D + N +T+ +G +G+ F +P ++G + ++
Sbjct: 1586 LQVTAL---DKDKGENAELIYTIEAG-NTGNMFKIEP-------VLGIITICKEPDMTTM 1634
Query: 425 NKYTVIIQVQDV-APPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQV 483
++ + I+V D +PP + +T +N P F Y +V+E T V +
Sbjct: 1635 GQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPK-FIHKDYQAEVNENVDIGTSVILI 1693
Query: 484 RATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN 543
A + QS+L+Y + G + +F INP +G + +D E T Y L IQATN
Sbjct: 1694 SA----ISQSTLIYEVKDGDIN----GIFTINPYSGVITTQKALDYERTSSYQLIIQATN 1745
Query: 544 NED-TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK-----LTCTDLDS 597
S+ TV + I++END P+ + Y +L + + +++ + TD DS
Sbjct: 1746 MAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADS 1805
Query: 598 SPRSFR-YSIGPGNVNNHFTFSPNAGS 623
+ + Y I FT + G+
Sbjct: 1806 NRNALLVYQIVESTAKKFFTVDSSTGA 1832
Score = 116 bits (290), Expect = 1e-25
Identities = 134/523 (25%), Positives = 213/523 (40%), Gaps = 48/523 (9%)
Query: 90 EQLDFETGPNIFDLQIYVKDE---VGVTDLQVLTVQVTDVNE---PPQFQGNLAEGLHLY 143
++LD+E ++L + KD+ V ++ + + V+V DVNE P F G
Sbjct: 996 KELDYEK-QQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGS--- 1051
Query: 144 IVERANPGF-IYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEA 199
+ E + G + QV A D ED+ R+ + Y + R S + G + + LD E
Sbjct: 1052 VKENSRIGTSVLQVTARD-EDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRET 1110
Query: 200 GHRSFHLIVEVRDSG--GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVAN 257
S+ L V D G L ++ E+ + + ++ND P + P V+E V
Sbjct: 1111 -MGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQ 1169
Query: 258 ITAEDPDDEGFPSHLLYSITTVS--KYFMINQLTGTIQVAQR-IDRDAGELRQNPTISLE 314
I AEDPD L Y IT+ + +F IN TG I R +DR+ Q LE
Sbjct: 1170 IQAEDPDSSS-NEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDRE-----QQAEHFLE 1223
Query: 315 VLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDD 374
V V D +++ I + V D NDN + + I +PER K F FD
Sbjct: 1224 VTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDR 1283
Query: 375 DSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQ 434
D E PN ++++ G G F+ G + AG+ + I+
Sbjct: 1284 D-EGPNAEISYSIVDGNDDGKFFIDPKTGM----------VSSRKQFTAGSYDILTIKAV 1332
Query: 435 DVAPPYYKNNVYVYI---LTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLP 491
D P + ++I P + PL FD P Y F V E VG V + P
Sbjct: 1333 DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTP 1392
Query: 492 QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVT 551
L+ GG + + F G + + +D E IY + ++ T+ + +
Sbjct: 1393 ----LWFDIVGG---NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQ 1445
Query: 552 VTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTD 594
V + +L+ ND P + +Y + + D+ T I + T D
Sbjct: 1446 VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRD 1488
Score = 108 bits (270), Expect = 2e-23
Identities = 117/484 (24%), Positives = 209/484 (43%), Gaps = 35/484 (7%)
Query: 118 VLTVQVTDVNEPPQFQGNLAEGLHLYIVER--ANPG-FIYQVEAFDPEDTSRNIPLSYFL 174
V+ V + D+N+ + GL Y + A PG IYQV A D +D N ++Y L
Sbjct: 2069 VVRVNIEDIND----NSPVFVGLPYYAAVQVDAEPGTLIYQVTAID-KDKGPNGEVTYVL 2123
Query: 175 ISPPKSFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEV 233
F ++ N G + + + + + + + +D G ST +++ I +N +
Sbjct: 2124 QDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKAM 2183
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS--KYFMINQLTGT 291
P F P +V E++ T + +I A P+ +G ++Y I K F I+ TG
Sbjct: 2184 PVFDKPFYTASVNEDIRMNTPILSINATSPEGQG----IIYIIIDGDPFKQFNIDFDTGV 2239
Query: 292 IQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFS 351
++V +D + L + D G + + + +V DVNDNP + T++
Sbjct: 2240 LKVVSPLDYEV-----TSAYKLTIRASDALTGARAE-VTVDLLVNDVNDNPPIFDQPTYN 2293
Query: 352 IMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIG 411
+ E + GT +L + D DSE N ++ + + + + + SG I+
Sbjct: 2294 TTLSEASLIGTPVLQV--VSIDADSEN-NKMVHYQIVQDTYNSTDYFHIDSSSGLILTAR 2350
Query: 412 DLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVS 471
LD+E + T+ ++ D P + V V+I S N+ P +F++ Y VS
Sbjct: 2351 MLDHELVQHC------TLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVS 2404
Query: 472 ERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCE 530
E P V V+A+D D L YSI +G F ++ K+G + L
Sbjct: 2405 ELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTS----FLMDSKSGVITLSNHRKQR 2460
Query: 531 TTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKL 590
P+Y L + ++ TS+ V + +L N P + ++Y + ++ GT + + +
Sbjct: 2461 MEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRA 2520
Query: 591 TCTD 594
T D
Sbjct: 2521 TDGD 2524
Score = 95.5 bits (236), Expect = 2e-19
Identities = 115/463 (24%), Positives = 195/463 (42%), Gaps = 50/463 (10%)
Query: 185 ANGTLFSTTELDFEAG-----------HRSFHLI-VEVRDSGGLKASTE--LQVNIVNLN 230
++G S +D E G H +L+ + + D G + S+ L +N+ + N
Sbjct: 766 SDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDAN 825
Query: 231 DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTG 290
D P F + +LE GT + + A D D G + YS+ T ++ F IN TG
Sbjct: 826 DNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD-LGSNGEVTYSVLTDTQQFAINSSTG 884
Query: 291 TIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQE--NRIQITFIVEDVNDNPATCQKF 348
+ VA ++DR++ SL++ +D+ GQ+ + + + ++DVND
Sbjct: 885 IVYVADQLDRES-----KANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPS 939
Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408
++S+ V E GT++ L D + +++ + RF D A SG I
Sbjct: 940 SYSVKVLEDLPVGTVIAWLET---HDPDLGLGGQVRYSLVNDY--NGRFEIDKA-SGAIR 993
Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNN---VYVYILTSPENEFPLIFDRPS 465
L +LDYE Y + ++ +D P ++ V V ++ EN F +
Sbjct: 994 LSKELDYEKQ------QFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFA 1047
Query: 466 YVFDVSERRPARTRVGQVRATDKDLPQ-SSLLYSISTGGASLQYPNVFWINPKTGELQLV 524
V V E T V QV A D+D + + YSI G F I+ ++G +
Sbjct: 1048 VVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGL----GRFSIDDESGVITAA 1103
Query: 525 TKVDCETTPIYILRIQATNNEDT---SSVTVTVNILEENDEKPICTPNSYFLALPVDLKV 581
+D ET Y L + AT+ S++ V + + + ND P+ + Y+ PV ++
Sbjct: 1104 DILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY---PVVMEN 1160
Query: 582 G-TNIQNFKLTCTDLDSSP-RSFRYSIGPGNVNNHFTFSPNAG 622
++ ++ D DSS Y I GN N F + G
Sbjct: 1161 SPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTG 1203
Score = 92.8 bits (229), Expect = 1e-18
Identities = 120/483 (24%), Positives = 205/483 (42%), Gaps = 37/483 (7%)
Query: 125 DVNE-PPQFQGNLAEGLHLYIVER-ANPGFIYQVEAFDPEDTSRNIPLSYFLI-SPPKSF 181
DVN+ PP F ++ + + E A + +V+A DP D N + Y L S F
Sbjct: 3123 DVNDNPPVFS---SDHYNTCVYENTATKALLTRVQAVDP-DIGINRKVVYSLADSAGGVF 3178
Query: 182 RM-SANGTLFSTTELDFEAGHRSFHLIVEVRDSG---GLKASTELQVNIVNLNDEVPRFT 237
+ S++G + LD E S+++ V D L + T + + ++++ND P F
Sbjct: 3179 SIDSSSGIIILEQPLDREQ-QSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFE 3237
Query: 238 SPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FMINQLTGTIQVA 295
+ TV E+ SPGT V + A D G + + Y I + ++ F IN TG I V+
Sbjct: 3238 RRDYLVTVPEDTSPGTQVLAVFATSKDI-GTNAEITYLIRSGNEQGKFKINPKTGGISVS 3296
Query: 296 QRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVP 355
+ +D + + L V KD + + DVNDNP + +S ++
Sbjct: 3297 EVLDYELCK-----RFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVIS 3351
Query: 356 ERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDY 415
E G ++ L +D PN + +F++ +G + F DP G + + LD
Sbjct: 3352 EDALVGDSVILL---IAEDVDSQPNGQIHFSIVNG-DRDNEFTVDPV-LGLVKVKKKLDR 3406
Query: 416 ENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRP 475
E S Y++++Q D P + V I S N+ +F +Y + E +P
Sbjct: 3407 ERVSG------YSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKP 3460
Query: 476 ARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIY 535
T + Q+ TD+D + +S S + + F ++P G L+ + Y
Sbjct: 3461 VGTSILQLVVTDRDSFHNGPPFSFSILSGNEE--EEFVLDPH-GILRSAVVFQHTESLEY 3517
Query: 536 ILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTC 592
+L +QA ++ + S + V ++EE+ KP P F+ D G I T
Sbjct: 3518 VLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATD 3577
Query: 593 TDL 595
D+
Sbjct: 3578 QDM 3580
Score = 85.9 bits (211), Expect = 2e-16
Identities = 133/595 (22%), Positives = 241/595 (40%), Gaps = 92/595 (15%)
Query: 62 IVNSNPLTEAFRVN---WLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQV 118
IV +PL + F WL+ E +Q+D+E+ P ++L + KD+
Sbjct: 303 IVAGDPLDQFFLAKEGKWLN----EYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSA 358
Query: 119 LTV----QVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLS--- 171
L T P +F+ + + + I E + PG + + PE LS
Sbjct: 359 LKAVYIGNPTRDTVPIRFEKEVYD---VSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGE 415
Query: 172 ---YFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVN 228
YF I+P ++A + + + G LKA ++ ++I +
Sbjct: 416 DAVYFKINPRSGLIVTAR---------PLNTVKKEVYKLEVTNKEGDLKA--QVTISIED 464
Query: 229 LNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY-FMINQ 287
ND P F P V E + GT V ++A D D+G ++ YSI +++ F+INQ
Sbjct: 465 ANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASD-KDKGENGYITYSIASLNLLPFVINQ 523
Query: 288 LTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGG---QENRIQITFIVEDVNDNPAT 344
TG I + +D +P I +V+ +G E+ + +T + +VNDN
Sbjct: 524 FTGVISTTEELD-----FESSPEI-YRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPL 577
Query: 345 CQKFTFSIMVP-------ERTAKGTLLLD--------------LNKFCFDDDSEAPNNRF 383
+K ++ TA + +D L F + DS +
Sbjct: 578 FEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKK 637
Query: 384 NFTMPSGVGSGS----------RFLQDPAGSGKIVLIGDLDYEN----PSNLAAGNKYTV 429
+ T SG+ +G+ L DP VL G + ++ + +A +
Sbjct: 638 SLT-NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKL 696
Query: 430 IIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDR--PSYVFDVSERRPARTRVGQVRATD 487
+I+ + ++ + + + + FD+ PS V V E P + +++A D
Sbjct: 697 LIKAKANGKLNLEDGFLDFYSINRQGPY---FDKSFPSDV-AVKEDLPVGANILKIKAYD 752
Query: 488 KDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRI---QATN 543
D +L++IS G + F I+ +TG+L+++ +D E T +Y+L I N
Sbjct: 753 ADSGFNGKVLFTISDGNTD----SCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGN 808
Query: 544 NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSS 598
+ +S +T+N+ + ND P+ +SY + + +GT I + DL S+
Sbjct: 809 PQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
Score = 85.5 bits (210), Expect = 2e-16
Identities = 114/474 (24%), Positives = 190/474 (40%), Gaps = 54/474 (11%)
Query: 167 NIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRS-FHLIVEV-RDSGGLK-ASTELQ 223
N PL Y +++P F++ + + TT + F+ + + L+VE R+ L+ A ++
Sbjct: 2012 NEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVR 2071
Query: 224 VNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYF 283
VNI ++ND P F V + PGT++ +TA D D+G + Y + +F
Sbjct: 2072 VNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAID-KDKGPNGEVTYVLQDDYGHF 2130
Query: 284 MINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPA 343
IN +G + + + + D + TI L KD +++ + VN
Sbjct: 2131 EINPNSGNVILKEAFNSDLSNIEYGVTI----LAKDGGKPSLSTSVELPITI--VNKAMP 2184
Query: 344 TCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVG------SGSRF 397
K ++ V E T +L +N T P G G G F
Sbjct: 2185 VFDKPFYTASVNEDIRMNTPILSINA----------------TSPEGQGIIYIIIDGDPF 2228
Query: 398 LQ--DPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPEN 455
Q +G + ++ LDYE S Y + I+ D A + V V +L + N
Sbjct: 2229 KQFNIDFDTGVLKVVSPLDYEVTS------AYKLTIRASD-ALTGARAEVTVDLLVNDVN 2281
Query: 456 EFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWI 514
+ P IFD+P+Y +SE T V QV + D D + ++ Y I + + F I
Sbjct: 2282 DNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD--TYNSTDYFHI 2339
Query: 515 NPKTGELQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTP--- 568
+ +G + +D E L++++ ++ +S V V + I + ND P+
Sbjct: 2340 DSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIY 2399
Query: 569 NSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAG 622
SY L T +Q +D D YSI GN F +G
Sbjct: 2400 ESYVSELAPRGHFVTCVQASDADSSDFD----RLEYSILSGNDRTSFLMDSKSG 2449
Score = 82.8 bits (203), Expect = 1e-15
Identities = 141/613 (23%), Positives = 243/613 (39%), Gaps = 97/613 (15%)
Query: 83 EVVTTGMEQLDFETGPNIFDLQIYVK--DEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEG 139
+V+TT E+LD E P D+ I+V+ D G T + V V D N+ PQF
Sbjct: 2551 QVITT--ERLDREN-PLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMT----- 2602
Query: 140 LHLYIVERANPG---FIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELD 196
+ RA+ G + QV+A DP+D + N ++Y L S A+ ++ E+D
Sbjct: 2603 VEYRASVRADVGRGHLVTQVQAIDPDDGA-NSRITYSLYS-------EASVSVADLLEID 2654
Query: 197 FEAG------------HRSFHLIVEVRDSGGLKASTELQVNIVNLNDE--VPRFTSPTRV 242
+ G + V+ D G + + V I L E +P FT
Sbjct: 2655 PDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYS 2714
Query: 243 YTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSK--------YFMINQLTGTIQV 294
+T+ E+ + G+ V + PS ++ T + F+I Q TGTI++
Sbjct: 2715 FTIAEDTAIGSTVDTLRI-------LPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKL 2767
Query: 295 AQRIDRD---AGELRQNPTISLEVLVKDRPYGGQENRIQITFIVE------DVNDNPATC 345
+R+DR+ A + TI L+ ++ I F V+ D+NDN
Sbjct: 2768 DKRLDRETSPAFHFKVAATIPLD-------------KVDIVFTVDVDIKVLDLNDNKPVF 2814
Query: 346 QKFTFSIMVPERTAKGTLLLDLNKFCFD--DDSEAPNNRFNFTMPSGVGSGSRFLQDPAG 403
+ ++ ++ E GT L + D + + + + + P V +
Sbjct: 2815 ETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNI---DSN 2871
Query: 404 SGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY-YKNNVYVYILTSPENEFPLIFD 462
+G I + DLD+E +T + D+ + + V + + N+ +F
Sbjct: 2872 TGWISTLKDLDHETDPT------FTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFA 2925
Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
+ Y +V E P V + D+D + S G + + + ++
Sbjct: 2926 QEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVY 2985
Query: 523 LVTKVDCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVG 582
+ +D E IY L I AT+ + V V++ + ND P+C +Y LP D +
Sbjct: 2986 VKRPLDREEQDIYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPED--IP 3043
Query: 583 TNIQNFKLTCTDLDSSPRSF-RYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFD 641
+N K++ D D + RYS+ G+ N+ F P +G T LL +
Sbjct: 3044 SNKIILKVSAKDADIGSNGYIRYSL-YGSGNSEFFLDPESGELKTLALLDR--------E 3094
Query: 642 KIWDYKLLVYVTD 654
+I Y L+ TD
Sbjct: 3095 RIPVYSLMAKATD 3107
Score = 77.8 bits (190), Expect = 4e-14
Identities = 136/580 (23%), Positives = 227/580 (39%), Gaps = 67/580 (11%)
Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90
V EN GTSV S ++L V + F +N SG V T +
Sbjct: 1680 VNENVDIGTSVILISAISQSTLI-------YEVKDGDINGIFTINPYSG-----VITTQK 1727
Query: 91 QLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPP------QFQGNLAEGLHLYI 144
LD+E + + L I + G+ + +Q+ D N+ Q+ G+L+E +
Sbjct: 1728 ALDYERTSS-YQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINS 1786
Query: 145 VERANPGFIYQVEAFDPEDTSRNIPLSYFLI-SPPKSFRM--SANGTLFSTTELDFEAGH 201
+ R+ + A D D++RN L Y ++ S K F S+ G + + LD E
Sbjct: 1787 IVRSLDNSPLVIRATDA-DSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHET-I 1844
Query: 202 RSFHLIVEVRDSGG--LKASTELQVNI--VNLNDEVPRFTSPTRVYTVLEELSPGTIVAN 257
FH V VRDSG L A + ++VNI ++ND P FT +L G V
Sbjct: 1845 AHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLK 1904
Query: 258 ITAEDPDDEGFPSHLLYSITTVS-KYFMINQLTGTIQVAQRIDRDAGELRQNPTISLE-- 314
++A DPD E P L YS+ S +F+I+ +G + + +N +S +
Sbjct: 1905 VSATDPDSE-VPPELTYSLMEGSLDHFLIDSNSGVLTI------------KNNNLSKDHY 1951
Query: 315 VLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDD 374
+L+ G + +T +V++ D+ + +S + E T + +N
Sbjct: 1952 MLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVN------ 2005
Query: 375 DSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQ 434
A NR N + + + + + SG I G P + Y ++++
Sbjct: 2006 ---AVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTG-----VPFDREEQELYELVVEAS 2057
Query: 435 DVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL-PQS 493
V V + N+ +F Y V T + QV A DKD P
Sbjct: 2058 RELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNG 2117
Query: 494 SLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPI-YILRIQATNNEDTS-SVT 551
+ Y + F INP +G + L + + + I Y + I A + S S +
Sbjct: 2118 EVTYVLQDDYGH------FEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTS 2171
Query: 552 VTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLT 591
V + I N P+ Y ++ D+++ T I + T
Sbjct: 2172 VELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211
Score = 52.4 bits (124), Expect = 2e-06
Identities = 131/598 (21%), Positives = 228/598 (38%), Gaps = 75/598 (12%)
Query: 105 IYVKDEVGVTDLQVLT---VQVTDVNE------PPQFQGNLAEGLHLYIVERANPGFIYQ 155
+ VK V DL+ T +QV D+N+ P + +AE L + Q
Sbjct: 127 LIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS-------VAQ 179
Query: 156 VEAFDPEDTSRNIPLSYFLISPPKSFRMS-ANGTLFSTTELDFEAGHRSFHLIVEVRDSG 214
V A D D N Y+ + F + +G + + L+++ +R + L + D G
Sbjct: 180 VTATDA-DIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNR-YDLEILAVDRG 237
Query: 215 -------GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEG 267
G+ ++ +L V+I +N+ P T V LE+ +V +D +
Sbjct: 238 MKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGE 297
Query: 268 FPSHLLYSITTVSKYFMINQLTGT----IQVAQRIDRDAGELRQNPTISLEVLVKDRPYG 323
S + + + ++F+ + I+ ++ID ++ N T+ KD+
Sbjct: 298 IESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ----AKDKGSP 353
Query: 324 GQENRIQITFIVEDVNDN-PATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNR 382
+ + ++ +I D P +K + + + E + G ++ + D E
Sbjct: 354 QKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVE----- 408
Query: 383 FNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYK 442
G + + + SG IV P N Y + +V
Sbjct: 409 ----YKLSPGEDAVYFKINPRSGLIVTA------RPLNTVKKEVYKL-----EVTNKEGD 453
Query: 443 NNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSIST 501
V I N+ F +P Y V+E P T V V A+DKD ++ + YSI
Sbjct: 454 LKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI-- 511
Query: 502 GGASLQYPNVFWINPKTGELQLVTKVDCETTP-IYILRIQATN----NEDTSSVTVTVNI 556
ASL F IN TG + ++D E++P IY ++A++ S V VT+ I
Sbjct: 512 --ASLNLLP-FVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRI 568
Query: 557 LEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFT 616
ND P+ + + D VG +I ++ D+D +Y I GN F
Sbjct: 569 GNVNDNSPLFEKVACQGVISYDFPVGGHIT--AVSAIDIDEL-ELVKYKIISGNELGFFY 625
Query: 617 FSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVT 674
+P++G + LT+ G F L + TD ++D V G V+
Sbjct: 626 LNPDSGVLQLKKSLTNSGIKNGNF------ALRITATDGENLADPMSINISVLHGKVS 677
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 119 bits (298), Expect = 1e-26
Identities = 126/459 (27%), Positives = 199/459 (43%), Gaps = 42/459 (9%)
Query: 187 GTLFSTTELDFEAGHRSFHLI-VEVRDSGGLKASTE--LQVNIVNLNDEVPRFTSPTRVY 243
G L LD+EA +F+++ V V D G + S+ L VN+ + ND PRF
Sbjct: 770 GLLTVAAPLDYEA--TNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQL 827
Query: 244 TVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAG 303
T+ E+ GT +A +T +D D E + Y++ + ++ F ++ LTG + V +DR++
Sbjct: 828 TISEDTEVGTTIAELTTKDADSED-NGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRES- 885
Query: 304 ELRQNPTISLEVLVKDRPYGGQE--NRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361
P L+V +D+P G + + + +EDVNDN C + VPE G
Sbjct: 886 ----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPG 941
Query: 362 TLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNL 421
T+L L+ D P + + G R +G ++L +LD+E +
Sbjct: 942 TVLTFLDA---SDPDLGPAGEVRYVLMDGAHGTFRV---DLMTGALILERELDFERRAG- 994
Query: 422 AAGNKYTVIIQVQDVAPPYYKN---NVYVYILTSPENEFPLIFDRPSYVFDVSERRPART 478
Y + + D P + +V V +L EN P F + V E P+ T
Sbjct: 995 -----YNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGT 1049
Query: 479 RVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILR 538
+V V A D D L G L F IN TG +Q + +D E Y L
Sbjct: 1050 QVIVVAAQDDDSGLDGELQYFLRAGTGLA---AFSINQDTGMIQTLAPLDREFASYYWLT 1106
Query: 539 IQATNNEDT--SSVT-VTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDL 595
+ A + SSVT V + + + ND P + ++ ++ D VGT++ +L D
Sbjct: 1107 VLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSV--LQLDAWDP 1164
Query: 596 DSSPR-SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSR 633
DSS + ++I GN F P VT LL T++
Sbjct: 1165 DSSSKGKLTFNITSGNYMGFFMIHP-----VTGLLSTAQ 1198
Score = 108 bits (269), Expect = 3e-23
Identities = 134/513 (26%), Positives = 219/513 (42%), Gaps = 48/513 (9%)
Query: 123 VTDVNE-PPQFQGNLAEGLHLYIVERANPG-FIYQVEAFDPEDTSRNIPLSYFLISP-PK 179
V DVN+ PQ L G + E PG FI +V A D DT N ++Y L P
Sbjct: 3001 VLDVNDNSPQCSQLLYTGK---VHEDVFPGHFILKVSATDL-DTDTNAQITYSLHGPGAH 3056
Query: 180 SFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTS 238
F++ + G L + T LD E F+L+ + D GG ++ +++ ++ND PRF
Sbjct: 3057 EFKLDPHTGELTTLTALDRERKD-VFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFP 3115
Query: 239 PTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI-TTVSKYFMINQLTGTIQVAQR 297
V + + T VA + A DP D+G + ++YS+ + +F I+ TG I++ +
Sbjct: 3116 SHCAVAVFDNTTVKTPVAVVFARDP-DQGANAQVVYSLPDSAEGHFSIDATTGVIRLEK- 3173
Query: 298 IDRDAGELRQNPTISLEVLVKDRPYGGQ---ENRIQITFIVEDVNDNPATCQKFTFSIMV 354
L+ P LE+ V+ G +T V + D S+ V
Sbjct: 3174 ------PLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQV 3227
Query: 355 PERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLD 414
PE GT +L L + + + + SG G RF D A +G + + LD
Sbjct: 3228 PEDAPPGTEVLQLATL-----TRPGAEKTGYRVVSGNEQG-RFRLD-ARTGILYVNASLD 3280
Query: 415 YENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERR 474
+E KY + I+ + + V + + NE F + Y V E
Sbjct: 3281 FE------TSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENA 3334
Query: 475 PARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTP 533
+ V ATD+D P S + YS+ GG L + F I+PK GELQ+ +D E
Sbjct: 3335 LVGDVILTVSATDEDGPLNSDITYSL-IGGNQLGH---FTIHPKKGELQVAKALDREQAS 3390
Query: 534 IYILRIQATN------NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQN 587
Y L+++AT+ +EDT + + + + ND P +Y + + +G+ +
Sbjct: 3391 SYSLKLRATDSGQPPLHEDTD---IAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQ 3447
Query: 588 FKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPN 620
L+ D + + + I GN + F +P+
Sbjct: 3448 LILSDPDSPENGPPYSFRITKGNNGSAFRVTPD 3480
Score = 107 bits (268), Expect = 4e-23
Identities = 134/519 (25%), Positives = 218/519 (42%), Gaps = 38/519 (7%)
Query: 92 LDFE-TGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVERAN 149
LD+E T I ++ +Y + ++LTV V D N+ P+F G L I E
Sbjct: 778 LDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPG---GYQLTISEDTE 834
Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSA-NGTLFSTTELDFEAGHRSFHLIV 208
G D+ N + Y L+SP + F + G L T LD E+ R + L V
Sbjct: 835 VGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEPR-YILKV 893
Query: 209 EVRDSGG----LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPD 264
E RD L + T+L + + ++ND P+ + V E+L PGT++ + A DPD
Sbjct: 894 EARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPD 953
Query: 265 DEGFPSHLLYSITTVSK-YFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYG 323
G + Y + + F ++ +TG + + + +D E R +SL RP
Sbjct: 954 -LGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDF---ERRAGYNLSLWASDGGRPLA 1009
Query: 324 GQENRIQITFIVEDVNDN--PATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNN 381
+ + IV DVN+N P F V E + GT ++ + DD +
Sbjct: 1010 -RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVV---AAQDDDSGLDG 1065
Query: 382 RFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYY 441
+ + +G G + + +G I + LD E S Y + + D
Sbjct: 1066 ELQYFLRAGTGLAAFSINQD--TGMIQTLAPLDREFASY------YWLTVLAVDRGSVPL 1117
Query: 442 KNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLP-QSSLLYSIS 500
+ VYI + N+ P + + + E P T V Q+ A D D + L ++I+
Sbjct: 1118 SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNIT 1177
Query: 501 TGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNED---TSSVTVTVNIL 557
+G Y F I+P TG L ++D E +IL + +N + S+ V V IL
Sbjct: 1178 SGN----YMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGIL 1233
Query: 558 EENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLD 596
+ ND PI + + + LP L + ++L +DLD
Sbjct: 1234 DVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLD 1272
Score = 105 bits (262), Expect = 2e-22
Identities = 149/616 (24%), Positives = 249/616 (40%), Gaps = 61/616 (9%)
Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90
V E+ PPGT V F L P G + V + FRV+ ++G
Sbjct: 934 VPEDLPPGT-VLTFLDASDPDLGPA--GEVRYVLMDGAHGTFRVDLMTGALILE-----R 985
Query: 91 QLDFETGPNIFDLQIYVKD---EVGVTDLQVLTVQVTDVNE---PPQFQGNLAEGLHLYI 144
+LDFE ++L ++ D + L + V V DVNE PP F + +G +
Sbjct: 986 ELDFERRAG-YNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQG---QV 1041
Query: 145 VERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEAGH 201
E + G V A +D+ + L YFL + S N G + + LD E
Sbjct: 1042 QENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFAS 1101
Query: 202 RSFHLIVEV-RDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITA 260
+ ++ V R S L + TE+ + + + ND P+ + ++ E+ GT V + A
Sbjct: 1102 YYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDA 1161
Query: 261 EDPDDEGFPSHLLYSITTVSK--YFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVK 318
DPD L ++IT+ + +FMI+ +TG + AQ++DR+ + LEV V
Sbjct: 1162 WDPDSSS-KGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEH-----ILEVTVL 1215
Query: 319 DRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEA 378
D ++ ++ + DVNDNP F++ +PER + + + D E
Sbjct: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSP-VSPGPVYRLVASDLDEG 1274
Query: 379 PNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAP 438
N R +++ S +G + + S AG + I+ D
Sbjct: 1275 LNGRVTYSIED---SDEEAFSIDLVTGVV--------SSSSTFTAGEYNILTIKATDSGQ 1323
Query: 439 PYYKNNVYVYILTSP---ENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSL 495
P +V ++I P + PL FD Y F V E P VG + +
Sbjct: 1324 PPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGR---PGLF 1380
Query: 496 LYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVTVTVN 555
++IS G + F I TG + + +D Y L ++ T+ T + V +
Sbjct: 1381 WFNISGGDKDMD----FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIF 1436
Query: 556 ILEE-NDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSI----GPGN 610
++ N +P Y + +P D G ++ ++ D D +S Y+I PG+
Sbjct: 1437 MIANINHHRPQFLETRYEVRVPQDTVPG--VELLRVQAIDQDKG-KSLIYTIHGSQDPGS 1493
Query: 611 VNNHFTFSPNAGSNVT 626
+ F P++G VT
Sbjct: 1494 A-SLFQLDPSSGVLVT 1508
Score = 105 bits (262), Expect = 2e-22
Identities = 149/611 (24%), Positives = 245/611 (40%), Gaps = 124/611 (20%)
Query: 121 VQVTDVNE-PPQFQG-----NLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFL 174
V V DVN+ PP F +++EGL + Q+ A D +D+ RN +SY +
Sbjct: 2260 VLVEDVNDNPPTFSQLVYTTSISEGLPAQTP-------VIQLLASD-QDSGRNRDVSYQI 2311
Query: 175 ISP----PKSFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIV 227
+ K F+++ + G + + ELD+EA + FH+ V D G L T + VN+
Sbjct: 2312 VEDGSDVSKFFQINGSTGEMSTVQELDYEA-QQHFHVKVRAMDKGDPPLTGETLVVVNVS 2370
Query: 228 NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITT--VSKYFMI 285
++ND P F P V E + G +V + A DPD S L Y I + ++F I
Sbjct: 2371 DINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRD-TSRLEYLILSGNQDRHFFI 2429
Query: 286 NQLTGTIQVAQ------------RIDRDAG-----------------------------E 304
N +G I + R+ G E
Sbjct: 2430 NSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQHLYEAE 2489
Query: 305 LRQNPTIS---LEVLVKDR---PYGGQENRIQITFIVEDVNDNP----ATCQKF------ 348
L +N + +++L D+ PYG + I E + NP AT QK
Sbjct: 2490 LAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLDRENST 2549
Query: 349 --TFSIMVPERTAKGTLLLDLNKFCFDDDSEAP----NNRFNFTMPSGVGSGSRFLQDPA 402
+I V R G + K D+++ P + + ++ S V S +Q A
Sbjct: 2550 ERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLA 2609
Query: 403 GSGKIVLIGDLDYE-NPSNLAAG----NKYTVIIQVQDV------------------APP 439
D+ Y NP +L N T +++V+D PP
Sbjct: 2610 YDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPP 2669
Query: 440 YYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSI 499
++ + V V + P+ F P Y F E P + +G V+A Q ++YS+
Sbjct: 2670 HWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAV---AAQDPVIYSL 2726
Query: 500 STGGA-SLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA---TNNEDTSSVTVTVN 555
G VF ++P TG +++ +D E+T +Y + + A N + S V+V +
Sbjct: 2727 VRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQ 2786
Query: 556 ILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDS---SPRSFRYSIGPG-NV 611
+ + ND +P+ + Y L ++ VGT++ ++T D D+ S+R S PG NV
Sbjct: 2787 VGDVNDNRPVFEADPYKAVLTENMPVGTSV--IQVTAIDKDTGRDGQVSYRLSADPGSNV 2844
Query: 612 NNHFTFSPNAG 622
+ F +G
Sbjct: 2845 HELFAIDSESG 2855
Score = 102 bits (254), Expect = 2e-21
Identities = 152/656 (23%), Positives = 264/656 (40%), Gaps = 83/656 (12%)
Query: 34 NSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLD 93
++PP S F+V+L LSPV PG + ++ L E L+G VT +E D
Sbjct: 1237 DNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEG-----LNGR----VTYSIEDSD 1287
Query: 94 FET-GPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGF 152
E ++ + + +LT++ TD +PP + + LH+ + P
Sbjct: 1288 EEAFSIDLVTGVVSSSSTFTAGEYNILTIKATDSGQPPL---SASVRLHIEWIPWPRPSS 1344
Query: 153 I----------YQVEAFDPEDTSRNI-------PLSYFLIS---PPKSFRMS-ANGTLFS 191
I + V DP + + L +F IS F + G++
Sbjct: 1345 IPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVI 1404
Query: 192 TTELDFEAGHRSFHLIVEVRDSGGLKASTELQV-NIVNLNDEVPRFTSPTRVYTVLEELS 250
LD +++L VEV D G +T++ + I N+N P+F V ++
Sbjct: 1405 ARPLDTRR-RSNYNLTVEVTD-GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTV 1462
Query: 251 PGTIVANITAEDPDDEGFPSHLLYSI-----TTVSKYFMINQLTGTIQVAQRIDRDAGEL 305
PG + + A D D L+Y+I + F ++ +G + ++D +G
Sbjct: 1463 PGVELLRVQAIDQDKG---KSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPS 1519
Query: 306 RQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLL 365
+ +L V+V+D+ + N + +T VED N +P + + VP+ A GT LL
Sbjct: 1520 QH----TLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELL 1575
Query: 366 DLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGN 425
+ D N ++++ G G F A G I L LD N +
Sbjct: 1576 QVRAM---DADRGVNAEVHYSLLKGNSEG--FFNINALLGIITLAQKLDQANHA------ 1624
Query: 426 KYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRA 485
+T+ ++ +D P + + V I P + IF + Y ++ E P + + V A
Sbjct: 1625 PHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA 1684
Query: 486 TDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNE 545
+ S + Y + G VF +N +G + K+D E Y L+I+ +N
Sbjct: 1685 ----MSPSEVTYELREGNKD----GVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMA 1736
Query: 546 DT-SSVTVTVNILEENDEKPICTPNSYF----LALPV-DLKVGTNIQNFKLTCTDLDSSP 599
+ V V V+I++END P+ +++ A P+ + + N F + +D D
Sbjct: 1737 GAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEA 1796
Query: 600 RSFR-YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTD 654
S Y I F P+ G+ L + S DY + + ++ VYV D
Sbjct: 1797 NSLLVYKILEPEALKFFKIDPSMGT----LTIVSEMDY----ESMPSFQFCVYVHD 1844
Score = 101 bits (251), Expect = 3e-21
Identities = 122/511 (23%), Positives = 215/511 (42%), Gaps = 56/511 (10%)
Query: 167 NIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFH-LIVEVRDSGGLKASTE--LQ 223
N LSYFL++ F M + + T + F+ + H L VEVRD+ + + ++
Sbjct: 1998 NDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVR 2057
Query: 224 VNIVNLNDEVPRFTSPTRVYTVLEE-LSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY 282
V+I ++ND P+F YT++++ PG ++ ++A D +D G + Y Y
Sbjct: 2058 VSIEDVNDNPPKFKH-LPYYTIIQDGTEPGDVLFQVSATD-EDLGTNGAVTYEFAEDYTY 2115
Query: 283 FMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNP 342
F I+ G I + + D A L+V+ +D ++ ++ V + NP
Sbjct: 2116 FRIDPYLGDISLKKPFDYQALN-----KYHLKVIARDGGTPSLQSEEEVLVTVRN-KSNP 2169
Query: 343 ATCQKFTFSIMVPERTAKGTLLLDLN-------KFCFDDDSEAPNNRFNFTMPSGVGSGS 395
+ + + VPE T +L + ++ E P F +GV
Sbjct: 2170 LFQSPY-YKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGV---- 2224
Query: 396 RFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPEN 455
+ + G LDYE+ + K+ ++ D A + + V +L N
Sbjct: 2225 -----------LTVTGPLDYESKT------KHVFTVRATDTALGSF-SEATVEVLVEDVN 2266
Query: 456 EFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQS-SLLYSISTGGASLQYPNVFWI 514
+ P F + Y +SE PA+T V Q+ A+D+D ++ + Y I G+ + F I
Sbjct: 2267 DNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVS--KFFQI 2324
Query: 515 NPKTGELQLVTKVDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSY 571
N TGE+ V ++D E + ++++A + D T V VN+ + ND P Y
Sbjct: 2325 NGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQY 2384
Query: 572 FLALPVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAG----SNVT 626
+ G + K+ D DS S Y I GN + HF + ++G N+
Sbjct: 2385 EANVSELATCGHLV--LKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLC 2442
Query: 627 RLLLTSRFDY-AGGFDKIWDYKLLVYVTDDN 656
+ L S ++ G D ++ + VY+ N
Sbjct: 2443 KKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
Score = 92.0 bits (227), Expect = 2e-18
Identities = 142/614 (23%), Positives = 257/614 (41%), Gaps = 55/614 (8%)
Query: 26 PATGNVAENSPPGTSVHKFSV--KLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFE 83
P + EN P GTSV + + K + V SN + E F ++ SG
Sbjct: 2801 PYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSN-VHELFAIDSESGWI-- 2857
Query: 84 VVTTGMEQLDFETGPNI-FDLQIYVKDE-VGVTDLQVLTVQVTDVNE-PPQFQGNLAEGL 140
T +++LD ET F + Y + + ++ ++ V +TD N+ P+F G
Sbjct: 2858 ---TTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGS 2914
Query: 141 HLYIVERANPG-FIYQVEAFDPEDTSRNIPLSYFLIS--PPKSFRMSANGT---LFSTTE 194
+VE + PG + ++ D + + +N ++ ++ P F +S G + S
Sbjct: 2915 ---VVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKT 2971
Query: 195 LDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTI 254
LD E H + +L+ G +AS +++ ++++ND P+ + V E++ PG
Sbjct: 2972 LDRE--HTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHF 3029
Query: 255 VANITAEDPDDEGFPSHLLYSITTVSKY-FMINQLTGTIQVAQRIDRDAGELRQNPTISL 313
+ ++A D D + + + YS+ + F ++ TG + +DR+ ++
Sbjct: 3030 ILKVSATDLDTDT-NAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDV-------F 3081
Query: 314 EVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
++ K GG+ + IT VEDVNDN ++ V + T T + + F D
Sbjct: 3082 NLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVV--FARD 3139
Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
D A N + +++P S A +G I L E P + + ++
Sbjct: 3140 PDQGA-NAQVVYSLPD---SAEGHFSIDATTGVIRL------EKPLQVRPQAPLELTVRA 3189
Query: 434 QDVAPPYYKNNV-YVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQ 492
D+ P + + V + ++ +F + V E P T V Q+ + +
Sbjct: 3190 SDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE 3249
Query: 493 SSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSS--- 549
+ Y + +G + F ++ +TG L + +D ET+P Y L I+ + +S
Sbjct: 3250 KTG-YRVVSGNEQGR----FRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
Query: 550 VTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGP 608
TV VNI + N+ +P + Y + + VG I ++ TD D S YS+
Sbjct: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVI--LTVSATDEDGPLNSDITYSLIG 3362
Query: 609 GNVNNHFTFSPNAG 622
GN HFT P G
Sbjct: 3363 GNQLGHFTIHPKKG 3376
Score = 86.3 bits (212), Expect = 1e-16
Identities = 158/713 (22%), Positives = 276/713 (38%), Gaps = 114/713 (15%)
Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90
++E SPPG+ V + ++P P ++ + F++N +G + TT +
Sbjct: 371 LSEFSPPGSRV------VMVRVTPAFPNLQYVLKPSSENVGFKLNARTGL---ITTTKL- 420
Query: 91 QLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDV----NEPPQFQGNLAEGLHLYIVE 146
+DF + Q++++ G Q TV V D+ N P F + +G + E
Sbjct: 421 -MDFHDRAHY---QLHIRTSPG----QASTVVVIDIVDCNNHAPLFNRSSYDGT---LDE 469
Query: 147 RANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEAGHRS 203
PG D N ++Y I+ PK+ S + G + ++ +D+E R
Sbjct: 470 NIPPGTSVLAVTATDRDHGENGYVTYS-IAGPKALPFSIDPYLGIISTSKPMDYELMKRI 528
Query: 204 FHLIVEVRDSGG---LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITA 260
+ V D G + + + + NLND P F ++ ++ G + ++A
Sbjct: 529 YTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSA 588
Query: 261 EDPDDEGFPSHLLYSITTVS--KYFMINQLTGTIQVAQR-IDRDAGELRQNPTISLEVLV 317
D D+ +L Y I + + +YF +N +G I + + I+ AG Q + SL++
Sbjct: 589 IDVDE---LQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAG---QPTSYSLKITA 642
Query: 318 KDRPYGGQENRIQITFIVEDVNDNPATCQK------FTFSIM-----------VPERTAK 360
D + IT + + + P TC K FT +I+ E T+
Sbjct: 643 SDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSL 702
Query: 361 GTLLLDLNKFCFDDD---------------------SEAPNNRFNFTMPSGVGSGSR--F 397
T ++ F+D + P+ FN + + G+
Sbjct: 703 STYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGC 762
Query: 398 LQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEF 457
+G + + LDYE A N Y + + V D+ P + + + N+
Sbjct: 763 FDIELETGLLTVAAPLDYE------ATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDN 816
Query: 458 PLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSS-LLYSISTGGASLQYPNVFWINP 516
F Y +SE T + ++ D D + + Y++ L F ++P
Sbjct: 817 APRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTL------LSPTEKFSLHP 870
Query: 517 KTGELQLVTKVDCETTPIYILRIQA----TNNEDTSSVTVTVNILEE-NDEKPICTPNSY 571
TGEL + +D E+ P YIL+++A + SVT + LE+ ND P C
Sbjct: 871 LTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHN 930
Query: 572 FLALPVDLKVGTNIQNFKLTCTDLDSSPR-SFRYSIGPGNVNNHFTFSPNAGSNVTRLLL 630
L +P DL GT + F L +D D P RY + G H TF + + L+L
Sbjct: 931 RLKVPEDLPPGT-VLTF-LDASDPDLGPAGEVRYVLMDG---AHGTFRVDLMTGA--LIL 983
Query: 631 TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPHP 683
D F++ Y L ++ +D R+ L + L + HP
Sbjct: 984 ERELD----FERRAGYNLSLWASDGGRPLARR---TLCHVEVIVLDVNENLHP 1029
Score = 79.0 bits (193), Expect = 2e-14
Identities = 124/581 (21%), Positives = 243/581 (41%), Gaps = 60/581 (10%)
Query: 74 VNWLSGTYFEVVTTG----MEQLDFETGPN-IFDLQIYVKDEVGVTDLQVLTVQVTDVNE 128
+N L+ F + G +++LD E + +++ +D G + + +TD N+
Sbjct: 2521 INKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDEND 2580
Query: 129 -PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFR--MSA 185
PPQF+ + V + +P + QV A+D D +N ++Y ++P + +
Sbjct: 2581 NPPQFKASEYTVSIQSNVSKDSP--VIQVLAYDA-DEGQNADVTYS-VNPEDLVKDVIEI 2636
Query: 186 NGTLFSTTELDFEAG--HRSFHLIVEVRDSGG--LKASTELQVNIVNLNDEVPRFTSPTR 241
N D G +++ ++ +D G + +++ +V +P+F+ P
Sbjct: 2637 NPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLY 2696
Query: 242 VYTVLEELSPGT---IVANITAEDPDDEGFPSHLLYSI-------TTVSKYFMINQLTGT 291
++ E+L G+ IV + A+DP ++YS+ + F ++ TG
Sbjct: 2697 TFSAPEDLPEGSEIGIVKAVAAQDP--------VIYSLVRGTTPESNKDGVFSLDPDTGV 2748
Query: 292 IQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFS 351
I+V + +D ++ +L Q ++V+ + + + V DVNDN + +
Sbjct: 2749 IKVRKPMDHESTKLYQ-----IDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYK 2803
Query: 352 IMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFL-QDPAGSGKIVLI 410
++ E GT ++ + D + + ++ + + GS L + SG I +
Sbjct: 2804 AVLTENMPVGTSVIQVTAI---DKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTL 2860
Query: 411 GDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDV 470
+LD E + ++ + V + + EN+ F Y V
Sbjct: 2861 QELDCETCQTY-----HFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSV 2915
Query: 471 SERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTK--V 527
E V ++ D D+ Q+ + T G L F I+ E ++ ++ +
Sbjct: 2916 VENSEPGELVATLKTLDADISEQNRQVTCYITEGDPL---GQFGISQVGDEWRISSRKTL 2972
Query: 528 DCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQN 587
D E T Y+LR+ A++ + +SVTV + +L+ ND P C+ Y + D+ G I
Sbjct: 2973 DREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFI-- 3030
Query: 588 FKLTCTDLDSSPRS-FRYSI-GPGNVNNHFTFSPNAGSNVT 626
K++ TDLD+ + YS+ GPG + F P+ G T
Sbjct: 3031 LKVSATDLDTDTNAQITYSLHGPG--AHEFKLDPHTGELTT 3069
Score = 70.1 bits (170), Expect = 9e-12
Identities = 143/619 (23%), Positives = 256/619 (41%), Gaps = 72/619 (11%)
Query: 29 GNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTG 88
G V ENSP GT V V S + + + AF +N +G +
Sbjct: 1039 GQVQENSPSGTQV--IVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTG-----MIQT 1091
Query: 89 MEQLDFETGPNIFDLQIYV-KDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVE 146
+ LD E + + V + V ++ + + ++VTD N+ PPQ + + I E
Sbjct: 1092 LAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAV---FYPSIQE 1148
Query: 147 RANPG-FIYQVEAFDPEDTSR-----NIP----LSYFLISPPKSFRMSANGTLFSTTELD 196
A G + Q++A+DP+ +S+ NI + +F+I P G L + +LD
Sbjct: 1149 DAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHP-------VTGLLSTAQQLD 1201
Query: 197 FEAGHRSFHLI-VEVRDSG--GLKASTELQVNIVNLNDEVPRFTSP---TRVYTVLEELS 250
E ++ H++ V V D+G LK+++ + V I+++ND P F+ R+ L +S
Sbjct: 1202 RE--NKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVS 1259
Query: 251 PGTIVANITAEDPDDEGFPSHLLYSI-TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNP 309
PG + + ++ DEG + YSI + + F I+ +TG + + AGE
Sbjct: 1260 PGPVYRLVASD--LDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTF--TAGEYN--- 1312
Query: 310 TISLEVLVKDRPYGGQENRIQITFIV-EDVNDNPATCQKFTFSIMVPERTAKGTLLLDLN 368
++++ +P R+ I +I + P + +S V E +N
Sbjct: 1313 ILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETD-------PVN 1365
Query: 369 KFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYT 428
E F F + G ++ GS IV+ LD SN Y
Sbjct: 1366 HMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGS--IVIARPLDTRRRSN------YN 1417
Query: 429 VIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDK 488
+ ++V D V+++++ + + P F Y V + + +V+A D+
Sbjct: 1418 LTVEVTD-GSRTIATQVHIFMIANINHHRPQ-FLETRYEVRVPQDTVPGVELLRVQAIDQ 1475
Query: 489 DLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPI-YILRIQATNNE-- 545
D SL+Y+I G ++F ++P +G L V K+D + P + L + + E
Sbjct: 1476 D-KGKSLIYTIH-GSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIP 1533
Query: 546 -DTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS-FR 603
+ V VT+++ + N P T Y ++P + GT + ++ D D +
Sbjct: 1534 IKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTEL--LQVRAMDADRGVNAEVH 1591
Query: 604 YSIGPGNVNNHFTFSPNAG 622
YS+ GN F + G
Sbjct: 1592 YSLLKGNSEGFFNINALLG 1610
Score = 68.9 bits (167), Expect = 2e-11
Identities = 91/410 (22%), Positives = 174/410 (42%), Gaps = 27/410 (6%)
Query: 203 SFHLIVEVRDSG-GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAE 261
S+ LI++ + L+A T + V+I++ ND P F+ P+ T+ E++ + + +TA
Sbjct: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTAT 173
Query: 262 DPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRP 321
D D G + Y+ T S+ F I+ +G + VA +++ + ++++ + K
Sbjct: 174 DA-DLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISE 232
Query: 322 YGGQENRIQITFIVED-VNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPN 380
G + + VE + PA + T T+L+D N + +S
Sbjct: 233 GNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVE-- 290
Query: 381 NRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY 440
+ G + ++ A S + L+ D L + + + +Q + + PY
Sbjct: 291 -----VVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYL---HGFNLSLQARSGSGPY 342
Query: 441 YKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSIS 500
+ + + + L P L F++ Y +SE P +RV VR T P + S
Sbjct: 343 FYSQIRGFHL-PPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA-FPNLQYVLKPS 400
Query: 501 TGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVTVTVNILEEN 560
+ F +N +TG + +D Y L I+ + + +S V ++I++ N
Sbjct: 401 SENVG------FKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQ--ASTVVVIDIVDCN 452
Query: 561 DEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSF-RYSI-GP 608
+ P+ +SY L ++ GT++ +T TD D + YSI GP
Sbjct: 453 NHAPLFNRSSYDGTLDENIPPGTSV--LAVTATDRDHGENGYVTYSIAGP 500
Score = 61.2 bits (147), Expect = 4e-09
Identities = 66/241 (27%), Positives = 103/241 (42%), Gaps = 20/241 (8%)
Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90
V E++PPGT V ++L+ P V S FR++ +G + +
Sbjct: 3227 VPEDAPPGTEV----LQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILYVNAS---- 3278
Query: 91 QLDFETGPNIF-DLQIYVKDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVERA 148
LDFET P F ++ K ++D+ + V +TDVNE PQF + ++E A
Sbjct: 3279 -LDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFP---QDPYSTRVLENA 3334
Query: 149 NPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEAGHRSFH 205
G + + ED N ++Y LI + + + G L LD E S+
Sbjct: 3335 LVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQA-SSYS 3393
Query: 206 LIVEVRDSG--GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDP 263
L + DSG L T++ + + ++ND PRF TV E G+ V + DP
Sbjct: 3394 LKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDP 3453
Query: 264 D 264
D
Sbjct: 3454 D 3454
Score = 57.0 bits (136), Expect = 8e-08
Identities = 115/539 (21%), Positives = 206/539 (38%), Gaps = 88/539 (16%)
Query: 80 TYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE------PPQFQ 133
+Y +++T ++LD E + + L+I + G ++ V + D N+ F
Sbjct: 1707 SYSGLIST-QKKLDHEKISS-YQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFV 1764
Query: 134 GNLAEGLHLY--IVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPP--KSFRMSAN-GT 188
G ++E LY I+++ N F+ D E S L Y ++ P K F++ + GT
Sbjct: 1765 GQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSL---LVYKILEPEALKFFKIDPSMGT 1821
Query: 189 LFSTTELDFEAGHRSFHLIVEVRDSGG----LKASTELQVNIVNLNDEVPRFTSPTRVYT 244
L +E+D+E+ SF V V D G ++ +++ ++ND PRF+
Sbjct: 1822 LTIVSEMDYES-MPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVA 1880
Query: 245 VLEELSPGTIVANITAEDPDDEGFPSHLLYSITT--VSKYFMINQLTGTIQVAQRIDRDA 302
++ + PG + + A D D E + YSI T + I+ +TG+I V
Sbjct: 1881 IVGPIHPGMELLMVRASDEDSE-----VNYSIKTGNADEAVTIHPVTGSISVL------- 1928
Query: 303 GELRQNPTI-----SLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPER 357
NP L + D Y ++ + + V D + + V E
Sbjct: 1929 -----NPAFLGLSRKLTIRASDGLY---QDTALVKISLTQVLDKSLQFDQDVYWAAVKEN 1980
Query: 358 TAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIG---DLD 414
L+ L A N N T+ + +G+ +G + G D +
Sbjct: 1981 LQDRKALVILG---------AQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDRE 2031
Query: 415 YENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERR 474
++ LA ++V+D P V + N+ P F Y + +
Sbjct: 2032 QQDTHELA--------VEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGT 2083
Query: 475 PARTRVGQVRATDKDLPQSSLLYSISTGGASLQYP---NVFWINPKTGELQLVTKVDCET 531
+ QV ATD+DL + G + ++ F I+P G++ L D +
Sbjct: 2084 EPGDVLFQVSATDEDLG--------TNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQA 2135
Query: 532 TPIYILRIQATNN-----EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI 585
Y L++ A + + V VTV N P+ Y + +P ++ + T I
Sbjct: 2136 LNKYHLKVIARDGGTPSLQSEEEVLVTV----RNKSNPLFQSPYYKVRVPENITLYTPI 2190
Score = 40.0 bits (92), Expect = 0.010
Identities = 32/111 (28%), Positives = 55/111 (49%), Gaps = 10/111 (9%)
Query: 420 NLAAGNKYTVIIQVQDVAPPYYK-NNVYVYILTSPENEFPLIFDRPSYVFDVSERRPART 478
N + YT+IIQ + V V+IL +N+ +F PSY +SE P ++
Sbjct: 108 NREVRDSYTLIIQATEKTLELEALTRVVVHILD--QNDLKPLFSPPSYRVTISEDMPLKS 165
Query: 479 RVGQVRATDKDLPQSS-LLYSISTGGASLQYPNVFWINPKTGELQLVTKVD 528
+ +V ATD DL Q++ Y+ +T +F I+P +G + + K++
Sbjct: 166 PICKVTATDADLGQNAEFYYAFNTRS------EMFAIHPTSGVVTVAGKLN 210
>gi|9256614 protocadherin beta 3 precursor [Homo sapiens]
Length = 796
Score = 118 bits (296), Expect = 2e-26
Identities = 141/613 (23%), Positives = 244/613 (39%), Gaps = 69/613 (11%)
Query: 2 QEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQ 61
Q ++ + L G+++G E+ +VAE G + + L + + Q
Sbjct: 13 QVLLLFVFLGGSLAGSESRRY-------SVAEEKEKGFLIANLAKDLGLRVEELAARGAQ 65
Query: 62 IVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTV 121
+V+ + F+++ +G E+L T P I QI +++ + ++ +
Sbjct: 66 VVSKGN-KQHFQLSHQTGDLLLNEKLDREELCGPTEPCILHFQILLQNPLQFVTNELRII 124
Query: 122 QVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSF 181
V D + P F+ + HL I+E PG + + + D RN L + I+P F
Sbjct: 125 DVND-HSPVFFENEM----HLKILESTLPGTVIPLGNAEDLDVGRN-SLQNYTITPNSHF 178
Query: 182 ----RMSANGTLFSTTELDFEAGHRS---FHLIVEVRDSGGLKASTELQVNI--VNLNDE 232
R +G + LD L + D G S Q+NI +++ND
Sbjct: 179 HVLTRSRRDGRKYPELVLDKALDREEQPELSLTLTALDGGSPPRSGTAQINIQVLDINDN 238
Query: 233 VPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPS---HLLYSITTVSKYFMINQLT 289
P F P VLE +++ ++A D D F + ++ + K F +N +T
Sbjct: 239 APEFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHASEEIRKTFQLNPIT 298
Query: 290 GTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFT 349
G +Q+ + ++ +A S EV ++ + GG + + V DVNDNP +
Sbjct: 299 GDMQLVKYLNFEAIN-------SYEVDIEAKDGGGLSGKSTVIVQVVDVNDNPPELTLSS 351
Query: 350 FSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVL 409
+ +PE + + L + F D N R ++ + + F P+ L
Sbjct: 352 VNSPIPENSGETVLAV----FSVSDLDSGDNGRVMCSIENNLP----FFLKPSVENFYTL 403
Query: 410 I--GDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYV 467
+ G LD E S +Y + I + D+ P K + +L S N+ F + SY
Sbjct: 404 VSEGALDRETRS------EYNITITITDLGTPRLKTKYNITVLVSDVNDNAPAFTQISYT 457
Query: 468 FDVSERRPARTRVGQVRATDKDL-PQSSLLYS-ISTGGASLQYPNVFWINPKTGELQLVT 525
V E +G V ATD+D + + YS + L ++ IN G L +
Sbjct: 458 LFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALR 517
Query: 526 KVDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVG 582
+D E + R+ AT+ +S V V +L+ ND NS F+ P
Sbjct: 518 SLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDAND-------NSPFVLYP------ 564
Query: 583 TNIQNFKLTCTDL 595
+QN CT+L
Sbjct: 565 --LQNGSAPCTEL 575
>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
Length = 799
Score = 118 bits (296), Expect = 2e-26
Identities = 157/634 (24%), Positives = 262/634 (41%), Gaps = 78/634 (12%)
Query: 208 VEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDE- 266
V+ S L+ +E + + ++ND P F + TV E GT V N+TA D DD
Sbjct: 139 VDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPV 198
Query: 267 -GFPSHLLYSITTVSKYFMINQLTGTIQVA-QRIDRDAGELRQNPTISLEVLVKDRPYGG 324
G + L+YSI YF I T I+ A +DR+A ++ + ++ GG
Sbjct: 199 YGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREA---KEEYLVVIQAKDMGGHSGG 255
Query: 325 QENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFN 384
+T + DVNDNP + + VPE GT + + +D N + +
Sbjct: 256 LSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTA---IGRVKANDQDIGENAQSS 312
Query: 385 FTMPSGVGSGSRFLQDPAGS--GKIVLIGDLDYENPSNLAAGNKYTVIIQVQDV--APPY 440
+ + G G+ + A + G I L LD+E + YT+ ++ +V P +
Sbjct: 313 YDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKS------YTLKVEAANVHIDPRF 366
Query: 441 -----YKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSL 495
+K+ V I+ +E P +F P+Y+ +V E + +GQV A D D+ S +
Sbjct: 367 SGRGPFKDTATVKIVVEDADE-PPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPI 425
Query: 496 LYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQAT---NNEDTSSVTV 552
+SI F IN G++ L T +D E + + + I AT N+ S V V
Sbjct: 426 RFSID---RHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPV 482
Query: 553 TVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVN 612
+ +L+ ND P + Y L + K G IQ D + F YS+ P VN
Sbjct: 483 AIKVLDVNDNAPEFA-SEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVN 541
Query: 613 N-HFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETG 671
N +FT N ++++ L + F+ K Y L + ++D L T
Sbjct: 542 NPNFTIKKNEDNSLSILAKHNGFNR----QKQEVYLLPIIISDSG-------NPPLSSTS 590
Query: 672 TVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLG---SILLLGLLV 728
T+T+ + + + + + A+ +P +++G +IL +L+
Sbjct: 591 TLTIRVCGCSNDGVVQSC----------------NVEAYVLPIGLSMGALIAILACIILL 634
Query: 729 YLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGEAIDPVTGE 788
++V+L + RH EPL K + E +++ + D EA D T +
Sbjct: 635 LVIVVLFVTLRRH-------KNEPLIIKDDEDVRE-NIIRYDDEGGGEEDTEAFDIATLQ 686
Query: 789 TYE-FNSKTGARKWKDPLTQMPKWKESSHQGAAP 821
+ N + K L MP+ QG AP
Sbjct: 687 NPDGINGFLPRKDIKPDLQFMPR------QGLAP 714
Score = 71.2 bits (173), Expect = 4e-12
Identities = 88/380 (23%), Positives = 159/380 (41%), Gaps = 38/380 (10%)
Query: 245 VLEELS-PGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAG 303
VLEE S P I+ D D + S F IN +TG I +R+DR
Sbjct: 70 VLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDR--- 126
Query: 304 ELRQNPTISLEVL--VKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361
E + T++ + + +P E + V+D+NDN + VPE + G
Sbjct: 127 EEKAEYTLTAQAVDWETSKPL---EPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILG 183
Query: 362 TLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNL 421
T + ++ DD + + +++ G F +P + + ++D E
Sbjct: 184 TSVTNVTATDADDPVYGNSAKLVYSILEG---QPYFSIEPETAIIKTALPNMDRE----- 235
Query: 422 AAGNKYTVIIQVQDVA--PPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTR 479
A +Y V+IQ +D+ + + + N+ P F + Y F V E T
Sbjct: 236 -AKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTA 294
Query: 480 VGQVRATDKDLPQSS-LLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILR 538
+G+V+A D+D+ +++ Y I G + + + G ++L +D ET Y L+
Sbjct: 295 IGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLK 354
Query: 539 IQATN------------NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586
++A N +DT++V + ++E+ DE P+ + +Y L + + + + I
Sbjct: 355 VEAANVHIDPRFSGRGPFKDTATVKI---VVEDADEPPVFSSPTYLLEVHENAALNSVIG 411
Query: 587 NFKLTCTDLDSSPRSFRYSI 606
D+ SSP R+SI
Sbjct: 412 QVTARDPDITSSP--IRFSI 429
Score = 65.5 bits (158), Expect = 2e-10
Identities = 73/251 (29%), Positives = 114/251 (45%), Gaps = 34/251 (13%)
Query: 112 GVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPG-FIYQVEAFDPEDTSRNIP 169
G++ LTV +TDVN+ PP+F +L H + E G I +V+A D +D N
Sbjct: 255 GLSGTTTLTVTLTDVNDNPPKFAQSL---YHFSVPEDVVLGTAIGRVKAND-QDIGENAQ 310
Query: 170 LSYFLISPP-------KSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRD---------S 213
SY +I S + +G + LDFE +S+ L VE +
Sbjct: 311 SSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFET-KKSYTLKVEAANVHIDPRFSGR 369
Query: 214 GGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLL 273
G K + +++ +V DE P F+SPT + V E + +++ +TA DPD P +
Sbjct: 370 GPFKDTATVKI-VVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSP--IR 426
Query: 274 YSI---TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ 330
+SI T + + F IN G I +A +DR+ I+ E+ Q +R+
Sbjct: 427 FSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEI-----RNHSQISRVP 481
Query: 331 ITFIVEDVNDN 341
+ V DVNDN
Sbjct: 482 VAIKVLDVNDN 492
Score = 57.4 bits (137), Expect = 6e-08
Identities = 108/496 (21%), Positives = 204/496 (41%), Gaps = 56/496 (11%)
Query: 121 VQVTDVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDT--SRNIPLSYFLIS 176
++V D+N+ P+F L H + E + G + V A D +D + L Y ++
Sbjct: 155 IKVQDINDNAPEF---LNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILE 211
Query: 177 PPKSFRMSANGTLFSTT--ELDFEAGHRSFHLIVEVRD----SGGLKASTELQVNIVNLN 230
F + + T +D EA + ++++ +D SGGL +T L V + ++N
Sbjct: 212 GQPYFSIEPETAIIKTALPNMDREA-KEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVN 270
Query: 231 DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPD-DEGFPSH---------LLYSITTVS 280
D P+F ++V E++ GT + + A D D E S L+ IT+ +
Sbjct: 271 DNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDA 330
Query: 281 KYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEV--LVKDRPYGGQ---ENRIQITFIV 335
+ G I++ + +D E +++ T+ +E + D + G+ ++ + +V
Sbjct: 331 Q-----AQDGIIRLRKPLD---FETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVV 382
Query: 336 EDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGS 395
ED D P T+ + V E A +++ + D D + RF+ + +
Sbjct: 383 EDA-DEPPVFSSPTYLLEVHENAALNSVIGQVT--ARDPDITSSPIRFSIDRHTDL---E 436
Query: 396 RFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPEN 455
R A GKI L LD E L+ + T+I ++ + V V I N
Sbjct: 437 RQFNINADDGKITLATPLDRE----LSVWHNITII--ATEIRNHSQISRVPVAIKVLDVN 490
Query: 456 EFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWIN 515
+ F F +P + + V A DKD P++ + S + PN
Sbjct: 491 DNAPEFASEYEAFLCENGKPGQV-IQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKK 549
Query: 516 PKTGELQLVTK---VDCETTPIYILRI---QATNNEDTSSVTVTVNILEENDEKPICTPN 569
+ L ++ K + + +Y+L I + N +S+ T+T+ + +++ + + N
Sbjct: 550 NEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCN 609
Query: 570 SYFLALPVDLKVGTNI 585
LP+ L +G I
Sbjct: 610 VEAYVLPIGLSMGALI 625
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 117 bits (294), Expect = 4e-26
Identities = 137/552 (24%), Positives = 239/552 (43%), Gaps = 46/552 (8%)
Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLI 175
++TVQV D+N+ P F ++ ++E G+ + V+A D D N L Y L
Sbjct: 490 LVTVQVLDINDNAPIF---VSTPFQATVLESVPLGYLVLHVQAIDA-DAGDNARLEYRLA 545
Query: 176 SPPKSFRMSAN-GTLFSTTELDFEAGHRSFHLI-VEVRDSG--GLKASTELQVNIVNLND 231
F + N GT + + + + F+ VE RD G L AS + V ++++ND
Sbjct: 546 GVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVND 605
Query: 232 EVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGT 291
P FT P + E+ + GT V ++A D D ++ + S T +++ + +Q G
Sbjct: 606 NNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGG 665
Query: 292 IQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFS 351
+ V+ + D RQ VL G +++ QI V D N + Q ++
Sbjct: 666 L-VSLALPLDYKLERQ------YVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYT 718
Query: 352 IMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIG 411
+ V E GT ++ ++ D+ N R + M + +F D A +G +
Sbjct: 719 VNVNEDRPAGTTVVLISA---TDEDTGENARITYFMEDSI---PQFRID-ADTGAVTTQA 771
Query: 412 DLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVS 471
+LDYE+ + YT+ I +D P + Y+ IL + N+ F R SY V
Sbjct: 772 ELDYEDQVS------YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825
Query: 472 ERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531
E P T V Q+ ATD+D + ++ GG F + +G ++ + ++D E
Sbjct: 826 EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGD--DGDGDFIVESTSGIVRTLRRLDREN 883
Query: 532 TPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF 588
Y+LR A + + + VTV +L+ ND P+ + + + + + +G +
Sbjct: 884 VAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA-- 941
Query: 589 KLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYK 647
++T TD D + Y I GN+ F +G LT+ D ++ +Y
Sbjct: 942 RVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE------LTALVDL--DYEDRPEYV 993
Query: 648 LLVYVTDDNLMS 659
L++ T L+S
Sbjct: 994 LVIQATSAPLVS 1005
Score = 102 bits (255), Expect = 1e-21
Identities = 97/383 (25%), Positives = 161/383 (42%), Gaps = 23/383 (6%)
Query: 184 SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVY 243
S G + LD++ R + L V D G + + ++ VN+ + N P F S
Sbjct: 662 SGGGLVSLALPLDYKL-ERQYVLAVTASD-GTRQDTAQIVVNVTDANTHRPVFQSSHYTV 719
Query: 244 TVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAG 303
V E+ GT V I+A D +D G + + Y + F I+ TG + +D +
Sbjct: 720 NVNEDRPAGTTVVLISATD-EDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYE-- 776
Query: 304 ELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTL 363
+ +L + +D + + + +V DVNDN + ++ V E T
Sbjct: 777 ---DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTS 833
Query: 364 LLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAA 423
+L ++ D N R +T G F+ + SG + + LD EN +
Sbjct: 834 VLQISA---TDRDSGLNGRVFYTFQGGDDGDGDFIVEST-SGIVRTLRRLDRENVA---- 885
Query: 424 GNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQV 483
+Y + D P + + V + N+ P +F++ + V E P V +V
Sbjct: 886 --QYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARV 943
Query: 484 RATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQAT 542
ATD D + ++Y I G P VF ++ +GEL + +D E P Y+L IQAT
Sbjct: 944 TATDPDEGTNAQIMYQIVEGNI----PEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT 999
Query: 543 NNEDTSSVTVTVNILEENDEKPI 565
+ S TV V +L+ ND P+
Sbjct: 1000 SAPLVSRATVHVRLLDRNDNPPV 1022
Score = 100 bits (248), Expect = 8e-21
Identities = 143/592 (24%), Positives = 235/592 (39%), Gaps = 57/592 (9%)
Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEV-----V 85
V EN P GT V ASL + P + +A + S +F +
Sbjct: 190 VPENQPAGTPV--------ASLRAIDPDEGEAGRLEYTMDAL-FDSRSNQFFSLDPVTGA 240
Query: 86 TTGMEQLDFET-GPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE--PPQFQGNLAEGLHL 142
T E+LD ET ++F + + L LT+ VTD N+ P Q E L
Sbjct: 241 VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLR- 299
Query: 143 YIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLI-----SPPKSFRMSANGTLFSTTELD 196
E G+ + V A D D N + Y L+ SP + F + + T
Sbjct: 300 ---ENLEVGYEVLTVRATDG-DAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
Query: 197 FEAGHRSFHLIVEV----RDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPG 252
S+ L VE RD G + + +++ + ND P+F+ V V E+++PG
Sbjct: 356 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
Query: 253 TIVANITAEDPDDEGFPSHLLYSITT--VSKYFMINQLTGTIQVAQRIDRDAGELRQNPT 310
V +TA D D+G + + YSI + F ++ TG + V +D E + T
Sbjct: 416 APVLRVTASD-RDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDY---ETTKEYT 471
Query: 311 ISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKF 370
+ + RP + + +T V D+NDN F V E G L+L +
Sbjct: 472 LRVRAQDGGRPPLSNVSGL-VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAI 530
Query: 371 CFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVI 430
D N R + + +GVG F + G+G I + +LD E + Y+
Sbjct: 531 ---DADAGDNARLEYRL-AGVGHDFPFTIN-NGTGWISVAAELDREEV------DFYSFG 579
Query: 431 IQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL 490
++ +D P + V + N+ F +P Y ++E T V V A D+D
Sbjct: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD- 638
Query: 491 PQSSLLYSISTGGASLQYPNVFWINPKTGE--LQLVTKVDCETTPIYILRIQATNNEDTS 548
S + Y I++G N F I ++G + L +D + Y+L + A++
Sbjct: 639 AHSVITYQITSGNTR----NRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQD 694
Query: 549 SVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR 600
+ + VN+ + N +P+ + Y + + D GT + T D + R
Sbjct: 695 TAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENAR 746
Score = 96.3 bits (238), Expect = 1e-19
Identities = 101/401 (25%), Positives = 171/401 (42%), Gaps = 31/401 (7%)
Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTV-----SKYFMINQL 288
P+F P+ TV E GT VA++ A DP DEG L Y++ + +++F ++ +
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDP-DEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKF 348
TG + A+ +DR+ T V +D + +T +V D ND+ ++
Sbjct: 238 TGAVTTAEELDRET-----KSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQ 292
Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGV-GSGSRFLQDPAGSGKI 407
+ + E G +L + D PN + + G GS S + SG I
Sbjct: 293 EYKESLRENLEVGYEVLTVRA---TDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVI 349
Query: 408 VLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYV 467
G +D E + + TV Q P V++ +N+ F YV
Sbjct: 350 RTRGPVDREEVESY----QLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYV 405
Query: 468 FDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTK 526
V E V +V A+D+D ++++ YSI +G A Q F+++ +TG L +V+
Sbjct: 406 VQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQ----FYLDAQTGALDVVSP 461
Query: 527 VDCETTPIYILRIQATNNE----DTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVG 582
+D ETT Y LR++A + S VTV +L+ ND PI + + + +G
Sbjct: 462 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521
Query: 583 TNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGS 623
+ + + D + R Y + V + F F+ N G+
Sbjct: 522 YLVLHVQAIDADAGDNAR-LEYRL--AGVGHDFPFTINNGT 559
Score = 73.6 bits (179), Expect = 8e-13
Identities = 96/406 (23%), Positives = 159/406 (39%), Gaps = 45/406 (11%)
Query: 295 AQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMV 354
A R+ + +L Q P + + GG+ R +VN P Q ++ V
Sbjct: 140 APRLRCQSCKLAQAPGLRAGERSPEESLGGRRKR--------NVNTAPQF-QPPSYQATV 190
Query: 355 PERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSR--FLQDPAGSGKIVLIGD 412
PE GT + L D E R +TM + S S F DP +G + +
Sbjct: 191 PENQPAGTPVASLRAI---DPDEGEAGRLEYTMDALFDSRSNQFFSLDPV-TGAVTTAEE 246
Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472
LD E S + + QD P + IL + N+ +F++ Y + E
Sbjct: 247 LDRETKST------HVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRE 300
Query: 473 RRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531
V VRATD D P +++LY + G VF I+P++G ++ VD E
Sbjct: 301 NLEVGYEVLTVRATDGDAPPNANILYRLLEGSGG-SPSEVFEIDPRSGVIRTRGPVDREE 359
Query: 532 TPIYILRIQATN-----NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586
Y L ++A++ +++ V +++ ++ND P + Y + + D+ G +
Sbjct: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV- 418
Query: 587 NFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWD 645
++T +D D + YSI GN F G+ L + S DY + +
Sbjct: 419 -LRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGA----LDVVSPLDY----ETTKE 469
Query: 646 YKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPHPTTIITTTP 691
Y L V D + +G VT+ + I I +TP
Sbjct: 470 YTLRVRAQDGG------RPPLSNVSGLVTVQVLDINDNAPIFVSTP 509
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 115 bits (289), Expect = 1e-25
Identities = 130/554 (23%), Positives = 231/554 (41%), Gaps = 75/554 (13%)
Query: 216 LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDE--GFPSHLL 273
++ +E + I ++ND P+F V TV E GT V +TA D DD G + ++
Sbjct: 145 MEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVV 204
Query: 274 YSITTVSKYFMINQLTGTIQVA-QRIDRDAGELRQNPTISLEVLVKDRPYGGQ----ENR 328
YSI YF ++ TG I+ A +DR+A E EV+++ + GGQ
Sbjct: 205 YSILQGQPYFSVDSKTGVIRTALMNMDREAKEY-------YEVIIQAKDMGGQLGGLAGT 257
Query: 329 IQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMP 388
+ + DVNDNP + + + V E + + + D E N +T+
Sbjct: 258 TTVNITLSDVNDNPPRFPQKHYQMSVLE---SAPISSTVGRVFAKDLDEGINAEMKYTIV 314
Query: 389 SGVGSGSRFLQ-DPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY------- 440
G G+ + + DP +G + + P + + YT ++V+ P
Sbjct: 315 DGDGADAFDISTDPN-----FQVGIITVKKPLSFESKKSYT--LKVEGANPHLEMRFLNL 367
Query: 441 --YKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYS 498
+++ V+I +E P +F+ Y +V E T + + A D D+ +S+ YS
Sbjct: 368 GPFQDTTTVHISVEDVDE-PPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYS 426
Query: 499 ISTGGASLQYPNVFWINPKTGELQLVTKVDCETTP---IYILRIQATNNEDTSSVTVTVN 555
I ++ F+++ TG L +D E I +L ++ N SV VT+
Sbjct: 427 IDRSSDPGRF---FYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIK 483
Query: 556 ILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNN-H 614
+L+ ND P P Y + + K G IQ D + + F YS+ P NN +
Sbjct: 484 VLDVNDNAPE-FPRFYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPN 542
Query: 615 FTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVT 674
FT N + T +LT R + ++ +L+ + ++S TGT+T
Sbjct: 543 FTIRDNQDN--TARILTRRSGFRQQEQSVFHLPILIADSGQPVLS---------STGTLT 591
Query: 675 LSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGSIL-----LLGLLVY 729
+ + +++ SP A+ +P ++ G+++ + LLV
Sbjct: 592 IQVCSCDDDGHVMSC----------------SPEAYMLPVSLSRGALIAILACIFVLLVL 635
Query: 730 LVVLLAKAIHRHCP 743
++++L+ HR P
Sbjct: 636 VLLILSMRRHRKQP 649
Score = 84.0 bits (206), Expect = 6e-16
Identities = 90/341 (26%), Positives = 147/341 (43%), Gaps = 37/341 (10%)
Query: 283 FMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYG-GQENRIQITFIVEDVNDN 341
F I+ TG I QR+DR E R T+ + L DR G E + ++D+NDN
Sbjct: 107 FTIDDTTGDIHAIQRLDR---EERAQYTLRAQAL--DRRTGRPMEPESEFIIKIQDINDN 161
Query: 342 PATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDP 401
+ VPE + GT ++ + DD + + R ++ + G +
Sbjct: 162 EPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYS----ILQGQPYFSVD 217
Query: 402 AGSGKI-VLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY--YKNNVYVYILTSPENEFP 458
+ +G I + ++D E A Y VIIQ +D+ V I S N+ P
Sbjct: 218 SKTGVIRTALMNMDRE------AKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNP 271
Query: 459 LIFDRPSYVFDVSERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPK 517
F + Y V E P + VG+V A D D + + Y+I G + + N +
Sbjct: 272 PRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQ 331
Query: 518 TGELQLVTKVDCETTPIYILRIQATNN------------EDTSSVTVTVNILEENDEKPI 565
G + + + E+ Y L+++ N +DT++V ++V E+ DE P+
Sbjct: 332 VGIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISV---EDVDEPPV 388
Query: 566 CTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSI 606
P YF+ +P D+ +GT IQ ++ D D + S RYSI
Sbjct: 389 FEPGFYFVEVPEDVAIGTTIQ--IISAKDPDVTNNSIRYSI 427
Score = 63.9 bits (154), Expect = 6e-10
Identities = 106/494 (21%), Positives = 204/494 (41%), Gaps = 52/494 (10%)
Query: 121 VQVTDVNE-PPQFQGNLAEGLHLYIVERANP--GFIYQVEAFDPEDTS--RNIPLSYFLI 175
+++ D+N+ P+F +G ++ V +P + QV A D +D + + + Y ++
Sbjct: 153 IKIQDINDNEPKF----LDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSIL 208
Query: 176 SPPKSFRMSANGTLFSTTELDFEAGHRSFH-LIVEVRDSGG----LKASTELQVNIVNLN 230
F + + + T ++ + + ++ +I++ +D GG L +T + + + ++N
Sbjct: 209 QGQPYFSVDSKTGVIRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVN 268
Query: 231 DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSIT--TVSKYFMI--- 285
D PRF +VLE + V + A+D DEG + + Y+I + F I
Sbjct: 269 DNPPRFPQKHYQMSVLESAPISSTVGRVFAKDL-DEGINAEMKYTIVDGDGADAFDISTD 327
Query: 286 -NQLTGTIQVAQRIDRDAGELRQNPTISLE-----VLVKDRPYGGQENRIQITFIVEDVN 339
N G I V + + + E +++ T+ +E + ++ G ++ + VEDV+
Sbjct: 328 PNFQVGIITVKKPL---SFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDVD 384
Query: 340 DNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQ 399
+ P F F + VPE A GT + ++ D + NN +++ G RF
Sbjct: 385 EPPVFEPGFYF-VEVPEDVAIGTTIQIISA----KDPDVTNNSIRYSIDRSSDPG-RFFY 438
Query: 400 DPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPL 459
+G ++ LD E S + + + ++ P +V V I N+
Sbjct: 439 VDITTGALMTARPLDREEFS------WHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAP 492
Query: 460 IFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTG 519
F R Y V E A + V A D+D P++ + S + PN + +
Sbjct: 493 EFPR-FYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDN 551
Query: 520 ELQLVTK--------VDCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSY 571
+++T+ PI I T ++T+ V +++ C+P +Y
Sbjct: 552 TARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDDGHVMSCSPEAY 611
Query: 572 FLALPVDLKVGTNI 585
LPV L G I
Sbjct: 612 M--LPVSLSRGALI 623
Score = 47.8 bits (112), Expect = 5e-05
Identities = 60/261 (22%), Positives = 107/261 (40%), Gaps = 20/261 (7%)
Query: 115 DLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQ-VEAFDPEDTSRNIPLSYF 173
D + + V DV+EPP F+ + + E G Q + A DP+ T+ +I S
Sbjct: 372 DTTTVHISVEDVDEPPVFEPGF---YFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSID 428
Query: 174 LISPPKSFRM--SANGTLFSTTELDFE--AGHRSFHLIVEVRDSGGLKASTELQVNIVNL 229
S P F G L + LD E + H L +E+ + + S + + ++++
Sbjct: 429 RSSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQV-GSVPVTIKVLDV 487
Query: 230 NDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLT 289
ND P F + V E G ++ ++A D DD H YS+ + N
Sbjct: 488 NDNAPEFPRFYEAF-VCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEA----ANNPN 542
Query: 290 GTIQ-----VAQRIDRDAGELRQNPTI-SLEVLVKDRPYGGQENRIQITFIVEDVNDNPA 343
TI+ A+ + R +G +Q ++ L +L+ D + +T V +D+
Sbjct: 543 FTIRDNQDNTARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDDGH 602
Query: 344 TCQKFTFSIMVPERTAKGTLL 364
+ M+P ++G L+
Sbjct: 603 VMSCSPEAYMLPVSLSRGALI 623
>gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precursor
[Homo sapiens]
Length = 837
Score = 115 bits (287), Expect = 2e-25
Identities = 140/602 (23%), Positives = 246/602 (40%), Gaps = 59/602 (9%)
Query: 5 IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVN 64
++L LG + G A + +V E + G+ V S L + +IV
Sbjct: 15 LLLCIFLGTLRGFRARQIRY-----SVPEETEKGSFVGNISKDLGLEPRELAKRGVRIV- 68
Query: 65 SNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT 124
S T+ F VN SG+ E+L ++++ V+D + + ++V + +
Sbjct: 69 SRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDIN 128
Query: 125 DVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMS 184
D P FQ + E + + E A PG + + D N SY L SP F +
Sbjct: 129 D--NAPSFQEDEVE---IKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-SPNNYFSLQ 182
Query: 185 ANG----------TLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDE 232
G L + + + EA H L++ D G K + ++V ++++ND
Sbjct: 183 LRGRTDGAKNPELVLEGSLDREKEAAHL---LLLTALDGGDPIRKGAVPIRVVVLDVNDH 239
Query: 233 VPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI----TTVSKYFMINQL 288
+P FT +V E +S GT V + A DP DEG ++YS + S+ F ++
Sbjct: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDP-DEGINGEVMYSFRNMESKASEIFQLDSQ 298
Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKF 348
TG +QV +D + E+ ++ + GG + V DVNDN
Sbjct: 299 TGEVQVRGSLDFEKYRF-------YEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITIT 351
Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408
+ + E + GT++ LN D N + + +P+ + + + K++
Sbjct: 352 SSINSILENSPPGTVIALLN---VQDQDSGENGQVSCFIPNHL--PFKLEKTYGNYYKLI 406
Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468
LD E Y + + D P +V++ + +N+ P +F SY
Sbjct: 407 TSRVLDRE------LVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA 460
Query: 469 DVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGA-SLQYPNVFWINPKTGELQLVTK 526
+ E P + V A D D Q++L+ YS++ + + IN TG L +
Sbjct: 461 YIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS 520
Query: 527 VDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGT 583
D E LR+ A ++ D +S+V++++ +L++ND P + ALP D G
Sbjct: 521 FDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDN----APEILYPALPTDGSTGV 576
Query: 584 NI 585
+
Sbjct: 577 EL 578
Score = 81.3 bits (199), Expect = 4e-15
Identities = 101/428 (23%), Positives = 182/428 (42%), Gaps = 52/428 (12%)
Query: 119 LTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176
+ V V DVN+ P F ++ + + E + G + V A DP++ + F
Sbjct: 229 IRVVVLDVNDHIPMFTQSV---YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNM 285
Query: 177 PPKSFRM----SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDE 232
K+ + S G + LDFE +R + + ++ +D GGL +T + + +V++ND
Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEK-YRFYEMEIQGQDGGGLFTTTTMLITVVDVNDN 344
Query: 233 VPRFTSPTRVYTVLEELSPGTIVA--NITAEDPDDEG-----FPSHLLYSI-TTVSKYFM 284
P T + + ++LE PGT++A N+ +D + G P+HL + + T Y+
Sbjct: 345 APEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYK 404
Query: 285 INQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPAT 344
+ +T + +DR EL Q+ I+L + P E + + V D NDNP
Sbjct: 405 L--ITSRV-----LDR---ELVQSYNITLTATDQGSPPLSAETHVWLN--VADDNDNPPV 452
Query: 345 CQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSG---SRFLQDP 401
++S +PE +G + + D DS+ N +++ G S ++
Sbjct: 453 FPHSSYSAYIPENNPRGASIFSVT--ALDPDSK-QNALVTYSLTDDTVQGVPLSSYVSIN 509
Query: 402 AGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIF 461
+ +G + + DYE +L + + +D P +NV + + +N+
Sbjct: 510 SNTGVLYALQSFDYEQFRDL------ELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEI 563
Query: 462 DRPSYVFDVS---ERRPARTRVG----QVRATDKDLPQSSLLYSISTGGASLQYPNVFWI 514
P+ D S E P G +V A DKD Q++ L S P +F +
Sbjct: 564 LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWL---SYRLLKASEPGLFAV 620
Query: 515 NPKTGELQ 522
TGE++
Sbjct: 621 GEHTGEVR 628
Score = 41.2 bits (95), Expect = 0.004
Identities = 57/245 (23%), Positives = 93/245 (37%), Gaps = 13/245 (5%)
Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413
VPE T KG+ + +++K + E G F +P SG ++ G +
Sbjct: 36 VPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSR---GKTQLFAVNPR-SGSLITAGRI 91
Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473
D E + + + V+D Y V V I+ +N F VSE
Sbjct: 92 DREELCETVSSCFLNMELLVEDTLKIY---GVEVEIIDINDNAPS--FQEDEVEIKVSEH 146
Query: 474 RPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532
R A D D+ +SL Y +S K EL L +D E
Sbjct: 147 AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKE 206
Query: 533 PIYILRIQATNNEDT---SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK 589
++L + A + D +V + V +L+ ND P+ T + Y +++P ++ GT +
Sbjct: 207 AAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVN 266
Query: 590 LTCTD 594
T D
Sbjct: 267 ATDPD 271
>gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precursor
[Homo sapiens]
Length = 935
Score = 115 bits (287), Expect = 2e-25
Identities = 140/602 (23%), Positives = 246/602 (40%), Gaps = 59/602 (9%)
Query: 5 IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVN 64
++L LG + G A + +V E + G+ V S L + +IV
Sbjct: 15 LLLCIFLGTLRGFRARQIRY-----SVPEETEKGSFVGNISKDLGLEPRELAKRGVRIV- 68
Query: 65 SNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT 124
S T+ F VN SG+ E+L ++++ V+D + + ++V + +
Sbjct: 69 SRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDIN 128
Query: 125 DVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMS 184
D P FQ + E + + E A PG + + D N SY L SP F +
Sbjct: 129 D--NAPSFQEDEVE---IKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-SPNNYFSLQ 182
Query: 185 ANG----------TLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDE 232
G L + + + EA H L++ D G K + ++V ++++ND
Sbjct: 183 LRGRTDGAKNPELVLEGSLDREKEAAHL---LLLTALDGGDPIRKGAVPIRVVVLDVNDH 239
Query: 233 VPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI----TTVSKYFMINQL 288
+P FT +V E +S GT V + A DP DEG ++YS + S+ F ++
Sbjct: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDP-DEGINGEVMYSFRNMESKASEIFQLDSQ 298
Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKF 348
TG +QV +D + E+ ++ + GG + V DVNDN
Sbjct: 299 TGEVQVRGSLDFEKYRF-------YEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITIT 351
Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408
+ + E + GT++ LN D N + + +P+ + + + K++
Sbjct: 352 SSINSILENSPPGTVIALLN---VQDQDSGENGQVSCFIPNHL--PFKLEKTYGNYYKLI 406
Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468
LD E Y + + D P +V++ + +N+ P +F SY
Sbjct: 407 TSRVLDRE------LVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA 460
Query: 469 DVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGA-SLQYPNVFWINPKTGELQLVTK 526
+ E P + V A D D Q++L+ YS++ + + IN TG L +
Sbjct: 461 YIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS 520
Query: 527 VDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGT 583
D E LR+ A ++ D +S+V++++ +L++ND P + ALP D G
Sbjct: 521 FDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDN----APEILYPALPTDGSTGV 576
Query: 584 NI 585
+
Sbjct: 577 EL 578
Score = 81.3 bits (199), Expect = 4e-15
Identities = 101/428 (23%), Positives = 182/428 (42%), Gaps = 52/428 (12%)
Query: 119 LTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176
+ V V DVN+ P F ++ + + E + G + V A DP++ + F
Sbjct: 229 IRVVVLDVNDHIPMFTQSV---YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNM 285
Query: 177 PPKSFRM----SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDE 232
K+ + S G + LDFE +R + + ++ +D GGL +T + + +V++ND
Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEK-YRFYEMEIQGQDGGGLFTTTTMLITVVDVNDN 344
Query: 233 VPRFTSPTRVYTVLEELSPGTIVA--NITAEDPDDEG-----FPSHLLYSI-TTVSKYFM 284
P T + + ++LE PGT++A N+ +D + G P+HL + + T Y+
Sbjct: 345 APEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYK 404
Query: 285 INQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPAT 344
+ +T + +DR EL Q+ I+L + P E + + V D NDNP
Sbjct: 405 L--ITSRV-----LDR---ELVQSYNITLTATDQGSPPLSAETHVWLN--VADDNDNPPV 452
Query: 345 CQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSG---SRFLQDP 401
++S +PE +G + + D DS+ N +++ G S ++
Sbjct: 453 FPHSSYSAYIPENNPRGASIFSVT--ALDPDSK-QNALVTYSLTDDTVQGVPLSSYVSIN 509
Query: 402 AGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIF 461
+ +G + + DYE +L + + +D P +NV + + +N+
Sbjct: 510 SNTGVLYALQSFDYEQFRDL------ELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEI 563
Query: 462 DRPSYVFDVS---ERRPARTRVG----QVRATDKDLPQSSLLYSISTGGASLQYPNVFWI 514
P+ D S E P G +V A DKD Q++ L S P +F +
Sbjct: 564 LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWL---SYRLLKASEPGLFAV 620
Query: 515 NPKTGELQ 522
TGE++
Sbjct: 621 GEHTGEVR 628
Score = 41.2 bits (95), Expect = 0.004
Identities = 57/245 (23%), Positives = 93/245 (37%), Gaps = 13/245 (5%)
Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413
VPE T KG+ + +++K + E G F +P SG ++ G +
Sbjct: 36 VPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSR---GKTQLFAVNPR-SGSLITAGRI 91
Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473
D E + + + V+D Y V V I+ +N F VSE
Sbjct: 92 DREELCETVSSCFLNMELLVEDTLKIY---GVEVEIIDINDNAPS--FQEDEVEIKVSEH 146
Query: 474 RPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532
R A D D+ +SL Y +S K EL L +D E
Sbjct: 147 AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKE 206
Query: 533 PIYILRIQATNNEDT---SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK 589
++L + A + D +V + V +L+ ND P+ T + Y +++P ++ GT +
Sbjct: 207 AAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVN 266
Query: 590 LTCTD 594
T D
Sbjct: 267 ATDPD 271
>gi|14196455 protocadherin gamma subfamily A, 11 isoform 3 precursor
[Homo sapiens]
Length = 750
Score = 115 bits (287), Expect = 2e-25
Identities = 140/602 (23%), Positives = 246/602 (40%), Gaps = 59/602 (9%)
Query: 5 IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVN 64
++L LG + G A + +V E + G+ V S L + +IV
Sbjct: 15 LLLCIFLGTLRGFRARQIRY-----SVPEETEKGSFVGNISKDLGLEPRELAKRGVRIV- 68
Query: 65 SNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT 124
S T+ F VN SG+ E+L ++++ V+D + + ++V + +
Sbjct: 69 SRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDIN 128
Query: 125 DVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMS 184
D P FQ + E + + E A PG + + D N SY L SP F +
Sbjct: 129 D--NAPSFQEDEVE---IKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-SPNNYFSLQ 182
Query: 185 ANG----------TLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDE 232
G L + + + EA H L++ D G K + ++V ++++ND
Sbjct: 183 LRGRTDGAKNPELVLEGSLDREKEAAHL---LLLTALDGGDPIRKGAVPIRVVVLDVNDH 239
Query: 233 VPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI----TTVSKYFMINQL 288
+P FT +V E +S GT V + A DP DEG ++YS + S+ F ++
Sbjct: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDP-DEGINGEVMYSFRNMESKASEIFQLDSQ 298
Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKF 348
TG +QV +D + E+ ++ + GG + V DVNDN
Sbjct: 299 TGEVQVRGSLDFEKYRF-------YEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITIT 351
Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408
+ + E + GT++ LN D N + + +P+ + + + K++
Sbjct: 352 SSINSILENSPPGTVIALLN---VQDQDSGENGQVSCFIPNHL--PFKLEKTYGNYYKLI 406
Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468
LD E Y + + D P +V++ + +N+ P +F SY
Sbjct: 407 TSRVLDRE------LVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA 460
Query: 469 DVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGA-SLQYPNVFWINPKTGELQLVTK 526
+ E P + V A D D Q++L+ YS++ + + IN TG L +
Sbjct: 461 YIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS 520
Query: 527 VDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGT 583
D E LR+ A ++ D +S+V++++ +L++ND P + ALP D G
Sbjct: 521 FDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDN----APEILYPALPTDGSTGV 576
Query: 584 NI 585
+
Sbjct: 577 EL 578
Score = 80.5 bits (197), Expect = 6e-15
Identities = 101/426 (23%), Positives = 180/426 (42%), Gaps = 52/426 (12%)
Query: 119 LTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176
+ V V DVN+ P F ++ + + E + G + V A DP++ + F
Sbjct: 229 IRVVVLDVNDHIPMFTQSV---YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNM 285
Query: 177 PPKSFRM----SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDE 232
K+ + S G + LDFE +R + + ++ +D GGL +T + + +V++ND
Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEK-YRFYEMEIQGQDGGGLFTTTTMLITVVDVNDN 344
Query: 233 VPRFTSPTRVYTVLEELSPGTIVA--NITAEDPDDEG-----FPSHLLYSI-TTVSKYFM 284
P T + + ++LE PGT++A N+ +D + G P+HL + + T Y+
Sbjct: 345 APEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYK 404
Query: 285 INQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPAT 344
+ +T + +DR EL Q+ I+L + P E + + V D NDNP
Sbjct: 405 L--ITSRV-----LDR---ELVQSYNITLTATDQGSPPLSAETHVWLN--VADDNDNPPV 452
Query: 345 CQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSG---SRFLQDP 401
++S +PE +G + + D DS+ N +++ G S ++
Sbjct: 453 FPHSSYSAYIPENNPRGASIFSVT--ALDPDSK-QNALVTYSLTDDTVQGVPLSSYVSIN 509
Query: 402 AGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIF 461
+ +G + + DYE +L + + +D P +NV + + +N+
Sbjct: 510 SNTGVLYALQSFDYEQFRDL------ELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEI 563
Query: 462 DRPSYVFDVS---ERRPARTRVG----QVRATDKDLPQSSLLYSISTGGASLQYPNVFWI 514
P+ D S E P G +V A DKD Q++ L S P +F +
Sbjct: 564 LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWL---SYRLLKASEPGLFAV 620
Query: 515 NPKTGE 520
TGE
Sbjct: 621 GEHTGE 626
Score = 41.2 bits (95), Expect = 0.004
Identities = 57/245 (23%), Positives = 93/245 (37%), Gaps = 13/245 (5%)
Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413
VPE T KG+ + +++K + E G F +P SG ++ G +
Sbjct: 36 VPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSR---GKTQLFAVNPR-SGSLITAGRI 91
Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473
D E + + + V+D Y V V I+ +N F VSE
Sbjct: 92 DREELCETVSSCFLNMELLVEDTLKIY---GVEVEIIDINDNAPS--FQEDEVEIKVSEH 146
Query: 474 RPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532
R A D D+ +SL Y +S K EL L +D E
Sbjct: 147 AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKE 206
Query: 533 PIYILRIQATNNEDT---SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK 589
++L + A + D +V + V +L+ ND P+ T + Y +++P ++ GT +
Sbjct: 207 AAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVN 266
Query: 590 LTCTD 594
T D
Sbjct: 267 ATDPD 271
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,785,776
Number of Sequences: 37866
Number of extensions: 1703753
Number of successful extensions: 6605
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 188
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 3678
Number of HSP's gapped (non-prelim): 843
length of query: 885
length of database: 18,247,518
effective HSP length: 111
effective length of query: 774
effective length of database: 14,044,392
effective search space: 10870359408
effective search space used: 10870359408
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.