BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|40255133 hypothetical protein LOC222256 [Homo sapiens] (885 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|40255133 hypothetical protein LOC222256 [Homo sapiens] 1779 0.0 gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 149 1e-35 gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 139 2e-32 gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 130 4e-30 gi|203097724 cadherin-like 29 [Homo sapiens] 127 3e-29 gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 124 3e-28 gi|11056063 protocadherin gamma subfamily A, 7 isoform 1 precurs... 124 5e-28 gi|14196477 protocadherin gamma subfamily A, 7 isoform 2 precurs... 124 5e-28 gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 122 1e-27 gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 122 1e-27 gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 122 1e-27 gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 122 1e-27 gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 122 1e-27 gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 122 1e-27 gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 122 1e-27 gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 122 1e-27 gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 122 1e-27 gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 122 1e-27 gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 122 1e-27 gi|16933557 dachsous 1 precursor [Homo sapiens] 122 1e-27 gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi... 120 4e-27 gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 119 1e-26 gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 119 1e-26 gi|9256614 protocadherin beta 3 precursor [Homo sapiens] 118 2e-26 gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens] 118 2e-26 gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 117 4e-26 gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 115 1e-25 gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precur... 115 2e-25 gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precur... 115 2e-25 gi|14196455 protocadherin gamma subfamily A, 11 isoform 3 precur... 115 2e-25 >gi|40255133 hypothetical protein LOC222256 [Homo sapiens] Length = 885 Score = 1779 bits (4609), Expect = 0.0 Identities = 885/885 (100%), Positives = 885/885 (100%) Query: 1 MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP 60 MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP Sbjct: 1 MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP 60 Query: 61 QIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT 120 QIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT Sbjct: 61 QIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT 120 Query: 121 VQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS 180 VQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS Sbjct: 121 VQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS 180 Query: 181 FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPT 240 FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPT Sbjct: 181 FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPT 240 Query: 241 RVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDR 300 RVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDR Sbjct: 241 RVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDR 300 Query: 301 DAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAK 360 DAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAK Sbjct: 301 DAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAK 360 Query: 361 GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN 420 GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN Sbjct: 361 GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN 420 Query: 421 LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV 480 LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV Sbjct: 421 LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV 480 Query: 481 GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQ 540 GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQ Sbjct: 481 GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQ 540 Query: 541 ATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR 600 ATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR Sbjct: 541 ATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR 600 Query: 601 SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSD 660 SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSD Sbjct: 601 SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSD 660 Query: 661 RKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGS 720 RKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGS Sbjct: 661 RKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGS 720 Query: 721 ILLLGLLVYLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGE 780 ILLLGLLVYLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGE Sbjct: 721 ILLLGLLVYLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGE 780 Query: 781 AIDPVTGETYEFNSKTGARKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEE 840 AIDPVTGETYEFNSKTGARKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEE Sbjct: 781 AIDPVTGETYEFNSKTGARKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEE 840 Query: 841 DELSGKAWAEDAGLGSRNEGGKLGNPKNRNPAFMNRAYPKPHPGK 885 DELSGKAWAEDAGLGSRNEGGKLGNPKNRNPAFMNRAYPKPHPGK Sbjct: 841 DELSGKAWAEDAGLGSRNEGGKLGNPKNRNPAFMNRAYPKPHPGK 885 >gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] Length = 4588 Score = 149 bits (376), Expect = 1e-35 Identities = 148/526 (28%), Positives = 249/526 (47%), Gaps = 44/526 (8%) Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPG-FIYQVEAFDPEDTSRNIPLSYFLI 175 ++ V+V D N+ P + L I E PG I Q+ A D D N ++Y L+ Sbjct: 3008 IVEVKVLDANDNSPVCEKTLYSDT---IPEDVLPGKLIMQISATDA-DIRSNAEITYTLL 3063 Query: 176 -SPPKSFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEV 233 S + F+++ + G L ++T LD E +HL+V D GG + + + ++ND Sbjct: 3064 GSGAEKFKLNPDTGELKTSTPLDREE-QAVYHLLVRATDGGGRFCQASIVLTLEDVNDNA 3122 Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYS-ITTVSKYFMINQLTGTI 292 P F++ TV E PGT++ + A D D G +LYS I + F IN+L+G I Sbjct: 3123 PEFSADPYAITVFENTEPGTLLTRVQATDA-DAGLNRKILYSLIDSADGQFSINELSGII 3181 Query: 293 QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352 Q+ + +DR EL+ T+SL+ + + P I ++ D+NDNP + + Sbjct: 3182 QLEKPLDR---ELQAVYTLSLKAVDQGLPRRLTATGTVIVSVL-DINDNPPVFEYREYGA 3237 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412 V E GT +L + + D EA N +++ SG G +F D + +G + +I + Sbjct: 3238 TVSEDILVGTEVLQV--YAASRDIEA-NAEITYSIISGNEHG-KFSID-SKTGAVFIIEN 3292 Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472 LDYE + ++Y + ++ D P + V + + N+ +F + +Y +SE Sbjct: 3293 LDYE------SSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISE 3346 Query: 473 RRPARTRVGQVRATDKDLPQSS-LLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531 V V A D D P +S + YSI G + F I+P GE+++ +D ET Sbjct: 3347 DAVLEQSVITVMADDADGPSNSHIHYSIIDGNQG----SSFTIDPVRGEVKVTKLLDRET 3402 Query: 532 TPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF 588 Y L +QA++N ++ TV +++ + ND P+ + +Y + + + VG ++ Sbjct: 3403 ISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSV--L 3460 Query: 589 KLTCTDLDSSPRS--FRYSIGPGNVNNHFTFSPNAGSNVTRLLLTS 632 +L TD DSS F ++I GN F +P +LLTS Sbjct: 3461 QLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQG------VLLTS 3500 Score = 117 bits (293), Expect = 5e-26 Identities = 144/606 (23%), Positives = 255/606 (42%), Gaps = 67/606 (11%) Query: 89 MEQLDFETGPNIFDLQIYVKDE---VGVTDLQVLTVQVTDVNE---PPQFQGNLAEGLHL 142 ++QLDFE +++L + KD+ V ++ + V+V DVNE PP F + +G Sbjct: 986 VQQLDFEK-KQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGT-- 1042 Query: 143 YIVERANPGFIYQVEAFDPEDTSRNIPLSYFLI--SPPKSFRMSAN-GTLFSTTELDFEA 199 + E A G + + ED R+ + Y + S F++ G + ++ LD E+ Sbjct: 1043 -VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101 Query: 200 GHRSFHLIVEVRDSGGLKAST--ELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVAN 257 + L V D G + S+ E+ + + ++ND P+ + P ++E V Sbjct: 1102 TSH-YWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQ 1160 Query: 258 ITAEDPDDEGFPSHLLYSITTVSK--YFMINQLTGTIQVAQR-IDRDAGELRQNPTISLE 314 I A DPD L+Y IT+ + +F I+ TG I R +DR+ Q LE Sbjct: 1161 IEAFDPDSSS-NDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDRE-----QQDEHILE 1214 Query: 315 VLVKDRPYGGQENRIQITFIVEDVNDN-PATCQKFTFSIMVPERTA----KGTLLLDLNK 369 V V D + ++ + D NDN P QKF + I +PER + L Sbjct: 1215 VTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKF-YKIRLPEREKPDRERNARREPLYH 1273 Query: 370 FCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTV 429 D E PN ++++ G G F++ G + +A +Y + Sbjct: 1274 VIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG-----------VVSSKRFSAAGEYDI 1322 Query: 430 I-IQVQDVAPPYYKNNVYVYI--LTSPENEF-PLIFDRPSYVFDVSERRPARTRVGQVRA 485 + I+ D P + ++I ++ P+ P+ F+ + F V E P +G + Sbjct: 1323 LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV 1382 Query: 486 TDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNE 545 +P L+ TGG Y + F ++ TG + + +D E Y L ++AT+ Sbjct: 1383 EPPGIP----LWFDITGG---NYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGT 1435 Query: 546 DTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR---SF 602 T V + +++ ND +P + + Y + +P D T I +++ D D + + Sbjct: 1436 TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEI--LQISAVDQDEKNKLIYTL 1493 Query: 603 RYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRK 662 + S P ++ F P GS L + + D+ + + + L V V D ++ R Sbjct: 1494 QSSRDPLSLKK-FRLDPATGS----LYTSEKLDH----EAVHQHTLTVMVRDQDVPVKRN 1544 Query: 663 KAEALV 668 A +V Sbjct: 1545 FARIVV 1550 Score = 115 bits (287), Expect = 2e-25 Identities = 130/543 (23%), Positives = 225/543 (41%), Gaps = 38/543 (6%) Query: 57 PGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDL 116 P F I+N + F+++ SG V++T D E FD+ + V +E + + Sbjct: 2011 PLFYHILNPD---RRFKISRTSG----VLSTTGTPFDREQ-QEAFDVVVEVTEEHKPSAV 2062 Query: 117 QVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANP--GFIYQVEAFDPEDTSRNIPLSYFL 174 + V+V + E + L Y V + + G + + D+ RN + Y+L Sbjct: 2063 AHVVVKV--IVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYL 2120 Query: 175 ISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVP 234 + F++ G + + + + ++ + + V +D G S E+ V I +N +P Sbjct: 2121 KEHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMP 2180 Query: 235 RFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FMINQLTGTI 292 F P + E + + V ++ A P EG + YSIT + F IN TG I Sbjct: 2181 VFEKPFYSAEIAESIQVHSPVVHVQANSP--EGL--KVFYSITDGDPFSQFTINFNTGVI 2236 Query: 293 QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352 V +D +A +P L + D G + + IV+D+NDNP + ++++ Sbjct: 2237 NVIAPLDFEA-----HPAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAV 2290 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412 + E + GT ++ + D DSE PN ++ M + +G I L+ Sbjct: 2291 TLSEASVIGTSVVQVR--ATDSDSE-PNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRT 2347 Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472 LDYE ++T+ ++ D P ++V V + + N+ P +F++ Y +SE Sbjct: 2348 LDYEQ------SRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401 Query: 473 RRPARTRVGQVRATDKDLPQ-SSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531 P V V+A D D L YSI +G F I+ TG + L Sbjct: 2402 HAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKH----FVIDSATGIITLSNLHRHAL 2457 Query: 532 TPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLT 591 P Y L + ++ SS V V ++ N P N Y + L + + T + K T Sbjct: 2458 KPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTT 2517 Query: 592 CTD 594 D Sbjct: 2518 DGD 2520 Score = 113 bits (282), Expect = 9e-25 Identities = 115/456 (25%), Positives = 204/456 (44%), Gaps = 41/456 (8%) Query: 187 GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVL 246 GT+ LD E +++L VE D G T++ + +++ ND P+F++ + Sbjct: 1409 GTIIVAKPLDAEQ-KSNYNLTVEATD-GTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIP 1466 Query: 247 EELSPGTIVANITAEDPDDEGFPSHLLYSITTVS-----KYFMINQLTGTIQVAQRIDRD 301 E+ +P T + I+A D D++ + L+Y++ + K F ++ TG++ ++++D + Sbjct: 1467 EDTAPETEILQISAVDQDEK---NKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHE 1523 Query: 302 AGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361 A + Q+ +L V+V+D+ + N +I V D ND+ ++ V E A G Sbjct: 1524 A--VHQH---TLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVG 1578 Query: 362 TLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNL 421 +++L + D + N +++ SG G+ F+ DP G I +LD N + Sbjct: 1579 SVVLQVTAL---DKDKGKNAEVLYSIESG-NIGNSFMIDPV-LGSIKTAKELDRSNQA-- 1631 Query: 422 AAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVG 481 +Y ++++ D P V I + + F Y ++SE + VG Sbjct: 1632 ----EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVG 1687 Query: 482 QVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA 541 V A QSS++Y I G + F INP +G + +D ET PIY L IQ Sbjct: 1688 MVTAHS----QSSVVYEIKDGNTG----DAFDINPHSGTIITQKALDFETLPIYTLIIQG 1739 Query: 542 TNNEDTS-SVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI---QNFKLTCTDLDS 597 TN S + TV V++ +END P+ Y + + + + +N L D+ Sbjct: 1740 TNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADA 1799 Query: 598 SPRS---FRYSIGPGNVNNHFTFSPNAGSNVTRLLL 630 S Y I +V+ +F + G+ T L L Sbjct: 1800 DKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSL 1835 Score = 100 bits (250), Expect = 5e-21 Identities = 110/437 (25%), Positives = 186/437 (42%), Gaps = 40/437 (9%) Query: 163 DTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEAGHRSFHLIVEVRDSG--GLK 217 D N ++Y +IS + + S + G +F LD+E+ H ++L VE D G L Sbjct: 3258 DIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHE-YYLTVEATDGGTPSLS 3316 Query: 218 ASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSIT 277 + VN+ ++ND P F+ T + E+ V + A+D D SH+ YSI Sbjct: 3317 DVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPS-NSHIHYSII 3375 Query: 278 TVSK--YFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFI- 334 ++ F I+ + G ++V + +DR+ TIS L G R+ T + Sbjct: 3376 DGNQGSSFTIDPVRGEVKVTKLLDRE--------TISGYTLTVQASDNGSPPRVNTTTVN 3427 Query: 335 --VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVG 392 V DVNDN + +S+++ E G +L L D+DS F FT+ +G Sbjct: 3428 IDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQL--VVTDEDSSHNGPPFFFTIVTG-N 3484 Query: 393 SGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTS 452 F +P G VL+ + + Y + ++V D P + Y+ I Sbjct: 3485 DEKAFEVNPQG----VLLTSSAIKRKEK----DHYLLQVKVADNGKPQLSSLTYIDIRVI 3536 Query: 453 PENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVF 512 E+ +P S + +G++ ATD+D+ +L YS+ Q N+F Sbjct: 3537 EESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQDV-YDTLTYSLDP-----QMDNLF 3590 Query: 513 WINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYF 572 ++ G+L K+D Y+L + T+ + T+ +TV+I + E T F Sbjct: 3591 SVSSTGGKLIAHKKLDIGQ---YLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTIAIRF 3647 Query: 573 LALPVDLKVGTNIQNFK 589 L + VG +NF+ Sbjct: 3648 ANLTPEEFVGDYWRNFQ 3664 Score = 87.4 bits (215), Expect = 5e-17 Identities = 136/568 (23%), Positives = 231/568 (40%), Gaps = 80/568 (14%) Query: 119 LTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGF----------IYQVE--AFDPEDTS- 165 LT+Q D PPQF + ++ +P F +Y+ E F P +T Sbjct: 334 LTLQAKDKGTPPQFSS-------VKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPV 386 Query: 166 ---RNIP----LSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKA 218 + IP L Y S P + S N + L+ ++ H +EV S KA Sbjct: 387 VMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS-DRKA 445 Query: 219 STELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITT 278 ST++ V ++ N P FT E + GT V +++A DP DEG ++ YSI Sbjct: 446 STKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDP-DEGENGYVTYSIAN 504 Query: 279 VSKY-FMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVED 337 ++ F I+ TG + ++ +D + + + T+ + PY +E + T + + Sbjct: 505 LNHVPFAIDHFTGAVSTSENLDYEL--MPRVYTLRIRASDWGLPY-RREVEVLATITLNN 561 Query: 338 VNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDD------DSEAPN--NRFNFTMPS 389 +NDN +K +P G + ++ D+ EA N + F+ S Sbjct: 562 LNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNS 621 Query: 390 GVGSGSRFLQDPAG------SGKIVLIGDLDYENPSNL---AAGNKYTVIIQVQD--VAP 438 GV S R L D G S +I ++ P + A + V +Q ++ VA Sbjct: 622 GVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAK 681 Query: 439 PYYKNNVYVYILTSPENEFPLIFDRPSY-------------VFDVSERRPARTRVGQVRA 485 + + L + + FD S V E +P + V + + Sbjct: 682 MLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNS 741 Query: 486 TDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN- 543 TD D L+Y++S G + F I+ +TG L++++ +D ETT Y L I + Sbjct: 742 TDLDTGFNGKLVYAVSGGNED----SCFMIDMETGMLKILSPLDRETTDKYTLNITVYDL 797 Query: 544 --NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS 601 + + + V +++ ND P SYF+ + D +V + I ++ TD D P Sbjct: 798 GIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEI--IQVEATDKDLGPNG 855 Query: 602 -FRYSIGPGNVNNHFTFSPNAGSNVTRL 628 YSI V + TFS ++ + V + Sbjct: 856 HVTYSI----VTDTDTFSIDSVTGVVNI 879 Score = 87.0 bits (214), Expect = 7e-17 Identities = 142/626 (22%), Positives = 245/626 (39%), Gaps = 74/626 (11%) Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90 ++E +PP T V + P + S P F +N+ +G + + Sbjct: 376 ISEFAPPNTPV------VMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQ 429 Query: 91 QLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANP 150 Q F+L++ D T + V + + PP+F + V Sbjct: 430 QAAH------FELEVTTSDRKASTKVLVKVLGAN--SNPPEFTQTAYKAAFDENVPIGTT 481 Query: 151 GFIYQVEAFDPEDTSRN-IPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 + + A DP++ + S ++ G + ++ LD+E R + L + Sbjct: 482 --VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIR 539 Query: 210 VRDSGGLKASTELQV----NIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDD 265 D GL E++V + NLND P F T+ +L G + ++A D D+ Sbjct: 540 ASD-WGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598 Query: 266 EGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQ 325 + + + + +F +N +G + + + + G + SL + D Sbjct: 599 LQLVQYQIEAGNELD-FFSLNPNSGVLSLKRSLMDGLGA--KVSFHSLRITATDGENFAT 655 Query: 326 ENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLL---DLNKFCFDDDS-EAPNN 381 I IT N C++ + M+ E+ + L ++ FD S A Sbjct: 656 PLYINITVAASHKLVN-LQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIP 714 Query: 382 RFNFTMPSG--------VGSGSRFLQ----DPAGSGKIVLI----------------GDL 413 +F T+P+G VGS F+ D +GK+V G L Sbjct: 715 QFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGML 774 Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473 +P + +KYT+ I V D+ P ++++ N+ P F + SY +VSE Sbjct: 775 KILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSED 834 Query: 474 RPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532 + + + QV ATDKDL P + YSI T + F I+ TG + + +D E Sbjct: 835 KEVHSEIIQVEATDKDLGPNGHVTYSIVTD------TDTFSIDSVTGVVNIARPLDRELQ 888 Query: 533 PIYILRIQATNN-----EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQN 587 + L+I+A + + S+V V V++ + ND P P +Y + + DL GT I Sbjct: 889 HEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW 948 Query: 588 FKLTCTDLDSSPRSFRYSI---GPGN 610 + DL S + RYS+ G GN Sbjct: 949 LEAHDPDLGQSGQ-VRYSLLDHGEGN 973 Score = 83.2 bits (204), Expect = 1e-15 Identities = 139/626 (22%), Positives = 258/626 (41%), Gaps = 84/626 (13%) Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLT------------EAFRVNWLS 78 +A+N+ P + ++SV+LS ++S I F +V ++ + +AF +N S Sbjct: 1659 IADNASPKFTSKEYSVELSETVS--IGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHS 1716 Query: 79 GTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE------PPQF 132 GT ++T + LDFET P I+ L I + G++ + V + D N+ ++ Sbjct: 1717 GT---IIT--QKALDFETLP-IYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY 1770 Query: 133 QGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRM---SANGTL 189 G ++E + V + + A D + S N L Y ++ P S+ G + Sbjct: 1771 TGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVEPSVHTYFAIDSSTGAI 1829 Query: 190 FSTTELDFEAGHRSFHLIVEVRDSGGLKASTE----LQVNIVNLNDEVPRFTSPTRVYTV 245 + LD+E FH V+V D G + E + V+++++ND P F P ++ Sbjct: 1830 HTVLSLDYEETS-IFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASL 1888 Query: 246 LEELSPGTIVANITAEDPDDEGFPSHLLYSIT--TVSKYFMINQLTGTIQVAQRIDRDAG 303 L G V + A D D F S L+YSIT + + F ++ TG + V ++ Sbjct: 1889 LLPTYKGVKVITVNATDADSSAF-SQLIYSITEGNIGEKFSMDYKTGALTV-----QNTT 1942 Query: 304 ELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFT---FSIMVPERTAK 360 +LR L V D + G +T + +V ++ + KFT +S +V E + + Sbjct: 1943 QLRSR--YELTVRASDGRFAG------LTSVKINVKESKESHLKFTQDVYSAVVKENSTE 1994 Query: 361 GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN 420 L + A N N + + + R + SG + G P + Sbjct: 1995 AETLAVIT---------AIGNPINEPLFYHILNPDRRFKISRTSGVLSTTG-----TPFD 2040 Query: 421 LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV 480 + V+++V + P +V V ++ +N+ +F Y V + Sbjct: 2041 REQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVI 2100 Query: 481 GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET-TPIYILRI 539 V A D+D ++ ++ ++ F I P GE+ L + + +T Y++ + Sbjct: 2101 RYVTAVDRDSGRNGEVHYYLK-----EHHEHFQIGP-LGEISLKKQFELDTLNKEYLVTV 2154 Query: 540 QATNNEDTS-SVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSS 598 A + + + S V V I N P+ Y + ++V + + + + +S Sbjct: 2155 VAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQA------NS 2208 Query: 599 PRSFR--YSIGPGNVNNHFTFSPNAG 622 P + YSI G+ + FT + N G Sbjct: 2209 PEGLKVFYSITDGDPFSQFTINFNTG 2234 Score = 81.6 bits (200), Expect = 3e-15 Identities = 123/558 (22%), Positives = 226/558 (40%), Gaps = 55/558 (9%) Query: 89 MEQLDFET-GPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVE 146 +E+LD ET + +++ KD G + V +TD N+ PQF+ E + I Sbjct: 2551 LEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYE---VNIGS 2607 Query: 147 RANPGF-IYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN----GTLFSTTELDFEAGH 201 A G + +V A D ++ S N ++Y + + +S + + + +T E + Sbjct: 2608 SAAKGTSVVKVLASDADEGS-NADITYAIEADSESVKENLEINKLSGVITTKESLIGLEN 2666 Query: 202 RSFHLIVEVRDSGGLKASTELQVNIVNLNDEV--PRFTSPTRVYTVLEELSPGTIVANIT 259 F V D+G + + V + L E+ P+F+ P +TV E++ GT + I Sbjct: 2667 EFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIR 2726 Query: 260 AEDPDDEGFPSHLLYSI-------TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTIS 312 AE +LYS+ + + F+I++ +G +++ + +D + + Q +I Sbjct: 2727 AEHSGT------VLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQF-SIL 2779 Query: 313 LEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCF 372 D + ++ V+D NDN + + + E G+ ++ + Sbjct: 2780 ARCTQDDHEMVAS---VDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRA--- 2833 Query: 373 DDDSEAPNNRFNFTMPSGVGSGSRFLQDPA---GSGKIVLIGDLDYENPSNLAAGNKYTV 429 D N + +++ ++ A +G I + +LD+E N Y + Sbjct: 2834 SDADSGTNGQVMYSLDQS--QSVEVIESFAINMETGWITTLKELDHEKRDN------YQI 2885 Query: 430 IIQVQDVAPPYYKNNVYVYILTSPE-NEFPLIFDRPSYVFDVSERRPARTRVGQVRATDK 488 + D ++ + +T + N+ P F Y VSE P + + TD Sbjct: 2886 KVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDA 2945 Query: 489 DLPQSS--LLYSISTGGASLQYPNVFWINPKTGELQLVTK--VDCETTPIYILRIQATNN 544 D + + + Y I TGG L F + E ++ K +D E Y+L I AT+ Sbjct: 2946 DSEEINRQVTYFI-TGGDPL---GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG 3001 Query: 545 EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRY 604 +S V V +L+ ND P+C Y +P D+ G I T D+ S+ Sbjct: 3002 TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYT 3061 Query: 605 SIGPGNVNNHFTFSPNAG 622 +G G F +P+ G Sbjct: 3062 LLGSG--AEKFKLNPDTG 3077 Score = 77.4 bits (189), Expect = 5e-14 Identities = 121/523 (23%), Positives = 223/523 (42%), Gaps = 59/523 (11%) Query: 204 FHLIVEVRDSG-GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAED 262 + LIV+ + ++A T+++V +++ ND P F+ + ++ E + T +A ++A D Sbjct: 116 YTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATD 175 Query: 263 PDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRP- 321 D G YS + F I+ +G I + R+D + +E+L DR Sbjct: 176 A-DIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLD-----YLETKLYEMEILAADRGM 229 Query: 322 --YG--GQENRIQITFIVEDVNDNPATCQKFTFSIMVPER-TAKGTLLLDLNKFCFDDDS 376 YG G + ++T +E N+ T S +R A + +D D D Sbjct: 230 KLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTVD------DCDQ 283 Query: 377 EAPNNRFNFTMPSG-VGSGSRFLQDPAGSG--KIVLIGDLDYENPSNLAAGNKYTVIIQV 433 A + + ++ +G + R ++ GS K+ IG +D+++ Y + +Q Sbjct: 284 GANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHP-----FGYNLTLQA 338 Query: 434 QDVAPPYYKNNVYVYILTSPE-NEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQ 492 +D P ++V V +TSP+ P+ F++ Y ++SE P T V V+A +P Sbjct: 339 KDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA----IPA 394 Query: 493 SSLLYSI--STGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSV 550 S L + ST G + F +N TG + ++ V + + ++ T ++ +S Sbjct: 395 YSHLRYVFKSTPGKA-----KFSLNYNTGLISILEPVKRQQAAHF--ELEVTTSDRKAST 447 Query: 551 TVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSF-RYSIGPG 609 V V +L N P T +Y A ++ +GT + + L+ D D + YSI Sbjct: 448 KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS--LSAVDPDEGENGYVTYSI--A 503 Query: 610 NVN------NHFTFSPNAGSNVTRLLLTSRFDYA-----GGFDKIWDYKLLVYVTDDNLM 658 N+N +HFT + + N+ L+ + G + ++L +T +NL Sbjct: 504 NLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLN 563 Query: 659 SDRKKAEALVETGTVTLSIKVIPHPTTI--ITTTPRPRVTYQV 699 + E + GT+ + V TT+ I V YQ+ Sbjct: 564 DNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQI 606 Score = 45.4 bits (106), Expect = 2e-04 Identities = 49/189 (25%), Positives = 81/189 (42%), Gaps = 17/189 (8%) Query: 458 PLIFDRPSYVFDVSERRPARTRVGQVRATDKDL--PQSSLLYSISTGGASLQYPNVFWIN 515 PL F Y V E A+T VG + P + Y I +G + + +I Sbjct: 31 PLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL 90 Query: 516 PKTGELQLVTK------VDCETTPIYILRIQAT--NNEDTSSVTVTVNILEENDEKPICT 567 L++ TK ++ E Y L ++A N + V V +L+ ND +P+ + Sbjct: 91 GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFS 150 Query: 568 PNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTR 627 P SY ++LP + + T+I T D+ ++ F YS + + F P +G Sbjct: 151 PTSYSVSLPENTAIRTSIARVSATDADIGTN-GEFYYSF--KDRTDMFAIHPTSGV---- 203 Query: 628 LLLTSRFDY 636 ++LT R DY Sbjct: 204 IVLTGRLDY 212 >gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] Length = 4981 Score = 139 bits (349), Expect = 2e-32 Identities = 148/549 (26%), Positives = 248/549 (45%), Gaps = 51/549 (9%) Query: 92 LDFETGPNIFDLQIY-VKDEVGVTDLQVLTVQVT--DVNE-PPQFQGNLAEGLHLYIVER 147 LD E G ++ + +Y ++ Q V++T D+N+ PP F ++ L L + E Sbjct: 1696 LDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDM---LDLTVEEN 1752 Query: 148 ANPGF-IYQVEAFDPEDTSRNIPLSYFLIS-PPKSFRMSA-NGTLFSTTELDFEAGHRSF 204 G I Q+ A D D N ++Y +IS SFR+ +G L +T LD E RS Sbjct: 1753 IGDGSKIMQLTAMDA-DEGANALVTYTIISGADDSFRIDPESGDLIATRRLDRE--RRSK 1809 Query: 205 HLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPD 264 + ++ D G + + + + ++ND P+F+ P + + E+ PG++VA I A D D Sbjct: 1810 YSLLVRADDGLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATD-D 1868 Query: 265 DEGFPSHLLYSITTVSK--YFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPY 322 D G + Y + + F +N +TG + + +D E++Q ++ V+ Sbjct: 1869 DSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDY---EVQQYYILT----VRAEDG 1921 Query: 323 GGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNR 382 GGQ I++ F + DVNDNP ++S + E G+ +L N D + N++ Sbjct: 1922 GGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFN---VTDADDGINSQ 1978 Query: 383 FNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQD---VAPP 439 +++ SG G +F D +G + ++ LD E+ S Y +++QV D + Sbjct: 1979 LTYSIASGDSLG-QFTVDK--NGVLKVLKALDRESQS------FYNLVVQVHDLPQIPAS 2029 Query: 440 YYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL-PQSSLLYS 498 + + V I+ N+ P F P + + E P T V + +ATD D P S + Y+ Sbjct: 2030 RFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATDPDSGPNSYIEYT 2088 Query: 499 ISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNED---TSSVTVTVN 555 + N F I GE++L ++D E Y L + AT+ +SS V V Sbjct: 2089 LLN-----PLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVM 2143 Query: 556 ILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR-SFRYSIGPGNVNNH 614 +L+ ND PI Y + + + GT+I ++ D D RY I GN N Sbjct: 2144 VLDINDNNPIFAQALYKVEINENTLTGTDI--IQVFAADGDEGTNGQVRYGIVNGNTNQE 2201 Query: 615 FTFSPNAGS 623 F G+ Sbjct: 2202 FRIDSVTGA 2210 Score = 137 bits (345), Expect = 4e-32 Identities = 163/623 (26%), Positives = 265/623 (42%), Gaps = 67/623 (10%) Query: 30 NVAENSPPGTSV-----HKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEV 84 ++ EN P GTSV H ++ LS I + P F ++ + GT + Sbjct: 1428 SIVENIPIGTSVISVTAHDPDADINGQLSYTI------IQQMPRGNHFTIDEVKGTIYTN 1481 Query: 85 VTTGMEQLDFETGPNIFDLQIYVKDEVGVTD-----LQVLTVQVTDVNEP-PQF--QGNL 136 ++D E N+F+L + D+ + L+ +T+ VTD+N+ P F Q L Sbjct: 1482 A-----EIDREFA-NLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNAL 1535 Query: 137 AEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS-PPKSFRMSA-NGTLFSTTE 194 A I + + A DP D N + Y +I+ +F + +G L + Sbjct: 1536 AADPSAVI-----GSVLTTIMAADP-DEGANGEIEYEIINGDTDTFIVDRYSGDLRVASA 1589 Query: 195 LDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSP-GT 253 L ++LIV D G + + ++ I+ + P FT P + T+L+E P GT Sbjct: 1590 L--VPSQLIYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQP-KYITILKEGEPIGT 1646 Query: 254 IVANITAEDPDDEGFP-SHLLYSI----TTVSKYFMINQLTGTIQVAQRIDRDAGELRQN 308 V +I A P P + + S+ TV + F I + TG IQ A +DR+ G Sbjct: 1647 NVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLY- 1705 Query: 309 PTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLN 368 + + + K + + R ++ ++D+NDNP + V E G+ ++ L Sbjct: 1706 -LVDVYAIEKSTAF-PRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLT 1763 Query: 369 KFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYT 428 D E N +T+ SG R DP SG ++ LD E S KY+ Sbjct: 1764 AM---DADEGANALVTYTIISGADDSFRI--DPE-SGDLIATRRLDRERRS------KYS 1811 Query: 429 VIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDK 488 ++++ D +++ + I S N+ F RP Y FD+ E + V + ATD Sbjct: 1812 LLVRADD---GLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDD 1868 Query: 489 DL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN-NED 546 D + Y ++ +F++NP TG L +D E YIL ++A + Sbjct: 1869 DSGVNGEITYIVNEDDED----GIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQ 1924 Query: 547 TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSI 606 +++ V NIL+ ND PI + NSY +L +L VG+ + F +T D D YSI Sbjct: 1925 FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDAD-DGINSQLTYSI 1983 Query: 607 GPGNVNNHFTFSPNAGSNVTRLL 629 G+ FT N V + L Sbjct: 1984 ASGDSLGQFTVDKNGVLKVLKAL 2006 Score = 129 bits (324), Expect = 1e-29 Identities = 152/617 (24%), Positives = 255/617 (41%), Gaps = 50/617 (8%) Query: 69 TEAFRVNWLSGTYFEVVTTGMEQLDFETGPNI----FDLQIYVKDEVGVTDLQVLTVQVT 124 +E FR+N +G F + + + NI F + + + + +T+ + Sbjct: 2915 SEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIV 2974 Query: 125 DVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLISPPK--S 180 D N+ PQF L + + G + +V A D +D N + YF+ + Sbjct: 2975 DSNDNAPQF---LKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGK 3031 Query: 181 FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDEVPRFTS 238 F++ + S +++F + V +D G L + + + + N P F+ Sbjct: 3032 FKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQ 3091 Query: 239 PTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSK--YFMINQLTGTIQVAQ 296 T+ E S G+IV ++A D D + YSI++ ++ F IN TG + +A+ Sbjct: 3092 SHMSATIPESHSIGSIVRTVSARDRD-AAMNGLIKYSISSGNEEGIFAINSSTGILTLAK 3150 Query: 297 RIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPE 356 +D EL Q +++ + D + + +T V DVNDN + V E Sbjct: 3151 ALDY---ELCQKHEMTISAI--DGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLE 3205 Query: 357 RTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYE 416 GT ++ LN D N +T+ S F+ DP +G I G LD+E Sbjct: 3206 NAPSGTTVIHLNA---TDADSGTNAVIAYTVQSS--DSDLFVIDP-NTGVITTQGFLDFE 3259 Query: 417 NPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPA 476 + Y + ++ +V + V I NE+ F Y F++SE P Sbjct: 3260 TKQS------YHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPK 3313 Query: 477 RTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYI 536 T VG+V A+D+DL ++ + G + + F IN KTG++ + +D E Sbjct: 3314 GTIVGEVFASDRDLGTDGEVHYLIFGNSRKKG---FQINKKTGQIYVSGILDREKEERVS 3370 Query: 537 LRIQATN-----NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLT 591 L++ A N D VTV V +L+ ND PI T N Y + + + +GT++ Sbjct: 3371 LKVLAKNFGSIRGADIDEVTVNVTVLDANDP-PIFTLNIYSVQISEGVPIGTHVTFVSAF 3429 Query: 592 CTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVY 651 +D S F Y IG GN N F+ +P G ++ +T+ D + + Y L V Sbjct: 3430 DSDSIPSWSRFSYFIGSGNENGAFSINPQTG----QITVTAELDR----ETLPIYNLSVL 3481 Query: 652 VTDDNLMSDRKKAEALV 668 D S A LV Sbjct: 3482 AVDSGTPSATGSASLLV 3498 Score = 119 bits (297), Expect = 2e-26 Identities = 147/602 (24%), Positives = 249/602 (41%), Gaps = 49/602 (8%) Query: 48 LSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYV 107 +SAS + ++ + F +N ++G E+ F + L++ Sbjct: 815 VSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSF------YQLKVVA 868 Query: 108 KDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSR 166 VT ++ + V D+N+ E ++ +VE G I+Q +A DP++ Sbjct: 869 SGGT-VTGDTMVNITVKDLNDNSPHFLQAIESVN--VVENWQAGHSIFQAKAVDPDEGVN 925 Query: 167 NIPLSYFLISPPKSFRMSA-NGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVN 225 + L +P F ++ NGT+ LD AG ++ L +S L V Sbjct: 926 GMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHAGSYQIEILASDMGVPQLSSSVILTVY 985 Query: 226 IVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSIT--TVSKYF 283 + ++ND P F + T+ E + + A D D G + Y+I F Sbjct: 986 VHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDS-GANGEIAYTIAEGNTGDAF 1044 Query: 284 MINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPA 343 I G + + +DR+ + L V+ DR + +T I+EDVNDN Sbjct: 1045 GIFP-DGQLYIKSELDRELQD-----RYVLMVVASDRAVEPLSATVNVTVILEDVNDNRP 1098 Query: 344 TCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNN--RFNFTMPSGVGSGSRFLQDP 401 ++ E G+ + K D PN R++F M + Sbjct: 1099 LFNSTNYTFYFEEEQRAGSFV---GKVSAVDKDFGPNGEVRYSFEMVQPD------FELH 1149 Query: 402 AGSGKIVLIGDLDYENPSNL--AAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPL 459 A SG+I D E+ A +TVI Q + P K+ V++ N+ Sbjct: 1150 AISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPL-KDQATVHVYMKDINDNAP 1208 Query: 460 IFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKT 518 F + Y +SE T+V +V A+D D + L+ YSI G Q F I+ + Sbjct: 1209 KFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQ----FAIDSTS 1264 Query: 519 GELQLVTKVDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLAL 575 G++ L+ K+D E TP Y L IQA ++ S+ T+ ++IL+END P ++ F+ + Sbjct: 1265 GQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDV 1324 Query: 576 PVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRF 634 ++++G + + +T TD DS + YSI N + F+ SPN GS + L + Sbjct: 1325 LENMRIGELVSS--VTATDSDSGDNADLYYSITGTNNHGTFSISPNTGS----IFLAKKL 1378 Query: 635 DY 636 D+ Sbjct: 1379 DF 1380 Score = 112 bits (281), Expect = 1e-24 Identities = 152/611 (24%), Positives = 251/611 (41%), Gaps = 64/611 (10%) Query: 79 GTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT--DVNEPPQFQGNL 136 G + +V+ G LD E P + L + V+D+ L V VT D+N+ P G+ Sbjct: 197 GAFLHLVSKG--GLDREVTPQ-YQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGS- 252 Query: 137 AEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTE- 194 + E A G + QV A D D N + Y L F+M L + E Sbjct: 253 -SHYQAGVPEDAVVGSSVLQVAAADA-DEGTNADIRYRLQDEGTPFQMDPETGLITVREP 310 Query: 195 LDFEAGHRSFHLIVEVRDSG--GLKASTELQVNIVNLNDEVP-----RFTSPTRVYTVLE 247 LDFEA R + L V+ D G L E + ++++ND P F + +R +V E Sbjct: 311 LDFEA-RRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDE 369 Query: 248 ELSPGTIVANITAEDPDDEGFPSHLLYSIT--TVSKYFMINQLT----GTIQVAQRIDRD 301 GT+VA +T D D ++ I ++F + I+VA +DR+ Sbjct: 370 NAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRE 429 Query: 302 AGELRQNPTISLEVLVKDRPYGG--------QENRIQITFIVEDVNDNPATCQKFTFSIM 353 + P+ +L V V D YG + + + V D+ND+P + + + Sbjct: 430 -----RIPSYNLTVSVSDN-YGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVN 483 Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413 + E G+ + ++ D N +++ SG G G + + +G G L Sbjct: 484 LSEEAPPGSYVSGISA---TDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGL 540 Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473 D E S + + + Q V P + V +L +E P+ Y V E Sbjct: 541 DRELASQIVLN----ISARDQGVHPKVSYAQLVVTLL-DVNDEKPVFSQPEGYDVSVVEN 595 Query: 474 RPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532 P T + +RATD DL + + +S+ + F ++P +G L ++ +D E Sbjct: 596 APTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRS---FRLDPVSGRLSTISSLDREEQ 652 Query: 533 PIYILRIQATN---NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK 589 Y L + AT+ +S + V++L+ ND P+ P YF + + G+ I Sbjct: 653 AFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVS 712 Query: 590 LTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLL 649 T DL ++ + +YSI G+ + F + +G TR+ L A Y+L Sbjct: 713 ATDPDLGTN-GTVKYSISAGD-RSRFQVNAQSGVISTRMALDREEKTA--------YQLQ 762 Query: 650 VYVTD-DNLMS 659 + TD NL S Sbjct: 763 IVATDGGNLQS 773 Score = 112 bits (280), Expect = 2e-24 Identities = 157/624 (25%), Positives = 259/624 (41%), Gaps = 78/624 (12%) Query: 62 IVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGV--TDLQVL 119 IVN N E FR++ ++G T + LD E P + L + D TD + Sbjct: 2193 IVNGNTNQE-FRIDSVTGAI-----TVAKPLDREKTPT-YHLTVQATDRGSTPRTDTSTV 2245 Query: 120 TVQVTDVN------EPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYF 173 ++ + D+N E + N+ E L P I QV A D +D N LSY Sbjct: 2246 SIVLLDINDFVPVFELSPYSVNVPENLGTL------PRTILQVVARD-DDRGSNSKLSYV 2298 Query: 174 LI--SPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNL 229 L + +F +SA+G L T LD E R F L++ DSG L + + V + ++ Sbjct: 2299 LFGGNEDNAFTLSASGELGVTQSLDRETKER-FVLMITATDSGSPALTGTGTINVIVDDV 2357 Query: 230 NDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLT 289 ND VP F S T+ E+ GT V + A D D + + I + F IN T Sbjct: 2358 NDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADAS---KNAVIRIIGGNSQFTINPST 2414 Query: 290 GTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQE---NRIQITFIVEDVNDNPATCQ 346 G I + +DR E + N T L V+ D G E + + V DVNDNP Q Sbjct: 2415 GQIITSALLDR---ETKDNYT--LVVVCSDA--GSPEPLSSSTSVLVTVTDVNDNPPRFQ 2467 Query: 347 KFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGK 406 + +P T G+ + + D PN+ ++++ SG S +F DP G Sbjct: 2468 HHPYVTHIPSPTLPGSFVFAVT---VTDADIGPNSELHYSL-SGRNS-EKFHIDPL-RGA 2521 Query: 407 IVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSY 466 I+ G L+ ++ T + V+D ++ V + + +FP + + Sbjct: 2522 IMAAGPLN--------GASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAK-EQ 2572 Query: 467 VFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTK 526 F E +P + V + T L + Y I++G N F I+ TG++ + Sbjct: 2573 TFMFPENQPVSSLVTTI--TGSSLRGEPMSYYIASGNLG----NTFQIDQLTGQVSISQP 2626 Query: 527 VDCETTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGT 583 +D E Y++ I+A + +S + + +L+ ND PI + + + +L + Sbjct: 2627 LDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENL---S 2683 Query: 584 NIQNFKLTCTDLDSSPR-SFRYSIGPGNVNNHFTFSPNAG----------SNVTRLLLTS 632 + ++ D DS P Y I GN+ N F+ + G V+ +LT Sbjct: 2684 PRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTI 2743 Query: 633 RFDYAGGFDKIWDYKLLVYVTDDN 656 + G + K+++ + D+N Sbjct: 2744 KSSDKGSPSQSTSVKVMINILDEN 2767 Score = 111 bits (277), Expect = 3e-24 Identities = 172/668 (25%), Positives = 280/668 (41%), Gaps = 88/668 (13%) Query: 31 VAENSPPGTSVHKFSVK-LSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGM 89 + E++P GT V + AS + VI +I+ N F +N +G +++T+ + Sbjct: 2373 IPEDAPTGTDVLLVNASDADASKNAVI----RIIGGN---SQFTINPSTG---QIITSAL 2422 Query: 90 EQLDFETGPNIFDLQIYVKDEVGVTDLQVLT---VQVTDVNE-PPQFQGNLAEGLHLYIV 145 LD ET N + L + D L T V VTDVN+ PP+FQ H Y+ Sbjct: 2423 --LDRETKDN-YTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQH------HPYVT 2473 Query: 146 ERANP----GFIYQVEAFDPEDTSRNIPLSY---------FLISPPKSFRMSANGTLFST 192 +P F++ V D D N L Y F I P + M+A G L Sbjct: 2474 HIPSPTLPGSFVFAVTVTDA-DIGPNSELHYSLSGRNSEKFHIDPLRGAIMAA-GPLNGA 2531 Query: 193 TELDFEAGHRSFHLIVEVRDSGGLKA--STELQVNIVNLNDEVPRFTSPTRVYTVLEELS 250 +E+ F V V+D G ST + V VN D P+ + + + E Sbjct: 2532 SEVTFS---------VHVKDGGSFPKTDSTTVTVRFVNKAD-FPKVRAKEQTFMFPENQP 2581 Query: 251 PGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPT 310 ++V IT G P + + F I+QLTG + ++Q +D E Q Sbjct: 2582 VSSLVTTITGSSL--RGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDF---EKIQKYV 2636 Query: 311 ISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKF 370 + +E P ++ IT + DVNDN ++ F + E + +L Sbjct: 2637 VWIEARDGGFPPFSSYEKLDITVL--DVNDNAPIFKEDPFISEILENLSPRKIL---TVS 2691 Query: 371 CFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVI 430 D DS PN + ++ + +G S + +G+I + LD E S+ Y + Sbjct: 2692 AMDKDS-GPNGQLDYEIVNGNMENSFSINH--ATGEIRSVRPLDREKVSH------YVLT 2742 Query: 431 IQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL 490 I+ D P +V V I EN+ F + + V E P V +V +D+D+ Sbjct: 2743 IKSSDKGSPSQSTSVKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDI 2801 Query: 491 PQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSS 549 +++ YSI ASL F INP TG++ + ++ E T Y +R+ A ++ T S Sbjct: 2802 GINAISRYSIMD--ASLP----FTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVS 2855 Query: 550 VTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPG 609 VT+ + + ND P + SY+L P ++G+ + T D S+ + F + Sbjct: 2856 TDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFI---K 2912 Query: 610 NVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE 669 + + +F + G + +L ++ GF + + VT SDR K + E Sbjct: 2913 SQSEYFRINATTGEIFNKQIL--KYQNVTGFSNVNINRHSFIVTS----SDRGKPSLISE 2966 Query: 670 TGTVTLSI 677 T TVT++I Sbjct: 2967 T-TVTINI 2973 Score = 105 bits (262), Expect = 2e-22 Identities = 122/505 (24%), Positives = 218/505 (43%), Gaps = 59/505 (11%) Query: 119 LTVQVTDVNE------PPQFQGNLAEGLHLYIVERANPG--FIYQVEAFDPEDTSRNIPL 170 + V + D+N+ P Q+ ++ E PG +I V A DP D N + Sbjct: 675 INVSLLDINDNSPVFYPVQYFAHIKEN---------EPGGSYITTVSATDP-DLGTNGTV 724 Query: 171 SYFLISPPKS-FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTE--LQVNIV 227 Y + + +S F+++A + ST ++ L + D G L++ + + + ++ Sbjct: 725 KYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVL 784 Query: 228 NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSK--YFMI 285 + D P F+ + V E ++ G V +++A D S++ Y ITT + F I Sbjct: 785 DTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMD---LNSNISYLITTGDQKGMFAI 841 Query: 286 NQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATC 345 NQ+TG + A IDR+ Q L+V+ G + + IT V+D+NDN Sbjct: 842 NQVTGQLTTANVIDREEQSFYQ-----LKVVASGGTVTG-DTMVNIT--VKDLNDNSPHF 893 Query: 346 QKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSG 405 + S+ V E G + D E N +++ + +G Sbjct: 894 LQAIESVNVVENWQAGHSIFQAKAV---DPDEGVNGMVLYSLKQ---NPKNLFAINEKNG 947 Query: 406 KIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPS 465 I L+G LD S Y + I D+ P ++V + + N+ +FD+ S Sbjct: 948 TISLLGPLDVHAGS-------YQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLS 1000 Query: 466 YVFDVSERRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLV 524 Y +SE P +R +V+A+DKD + Y+I+ G + F I P G+L + Sbjct: 1001 YEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTG----DAFGIFP-DGQLYIK 1055 Query: 525 TKVDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKV 581 +++D E Y+L + A++ +++V VTV + + ND +P+ +Y + + Sbjct: 1056 SELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRA 1115 Query: 582 GTNIQNFKLTCTDLDSSPR-SFRYS 605 G+ + K++ D D P RYS Sbjct: 1116 GSFVG--KVSAVDKDFGPNGEVRYS 1138 Score = 95.5 bits (236), Expect = 2e-19 Identities = 122/533 (22%), Positives = 231/533 (43%), Gaps = 49/533 (9%) Query: 72 FRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDE---VGVTDLQVLTVQVTDVNE 128 F ++ +SG E L G +F + D+ + D + V + D+N+ Sbjct: 1146 FELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDIND 1205 Query: 129 -PPQFQGNLAEGLHLYIVERA-NPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN 186 P+F L + I E A N + +V A D ++ + + + Y +I + + + + Sbjct: 1206 NAPKF---LKDFYQATISESAANLTQVLRVSASDVDEGNNGL-IHYSIIKGNEERQFAID 1261 Query: 187 GTLFSTT---ELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDEVPRFTSPTR 241 T T +LD+EA ++ L+++ DSG L ++ L ++I++ ND P F T Sbjct: 1262 STSGQVTLIGKLDYEATP-AYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTL 1320 Query: 242 VYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FMINQLTGTIQVAQRID 299 VLE + G +V+++TA D D G + L YSIT + + F I+ TG+I +A+++D Sbjct: 1321 FVDVLENMRIGELVSSVTATD-SDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLD 1379 Query: 300 RDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTA 359 + L L + KD+ + + + + V D NDNP + + E Sbjct: 1380 FETQSL-----YKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIP 1434 Query: 360 KGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPS 419 GT ++ + D D++ N + ++T+ + G+ F D G I ++D E Sbjct: 1435 IGTSVISVT--AHDPDADI-NGQLSYTIIQQMPRGNHFTIDEV-KGTIYTNAEIDRE--- 1487 Query: 420 NLAAGNKYTVIIQVQDVAPP-----YYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERR 474 N + + ++ D A P Y NV + ++T + P+ + + D S Sbjct: 1488 ---FANLFELTVKANDQAVPIETRRYALKNVTI-LVTDLNDNVPMFISQNALAADPS--A 1541 Query: 475 PARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTP 533 + + + A D D + Y I G + F ++ +G+L++ + + + Sbjct: 1542 VIGSVLTTIMAADPDEGANGEIEYEIINGDT-----DTFIVDRYSGDLRVASAL-VPSQL 1595 Query: 534 IYILRIQATN-NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI 585 IY L + AT+ + T + I+ + + P+ T Y L +GTN+ Sbjct: 1596 IYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNV 1648 Score = 94.0 bits (232), Expect = 6e-19 Identities = 122/483 (25%), Positives = 201/483 (41%), Gaps = 43/483 (8%) Query: 119 LTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176 +T+ VTD+N+ P+F +L E G + QV A DP++ S N + YF+ S Sbjct: 2858 VTIFVTDINDNAPRFSRT---SYYLDCPELTEIGSKVTQVFATDPDEGS-NGQVFYFIKS 2913 Query: 177 PPKSFRMSAN-GTLFSTTELDFE---------AGHRSFHLIVEVRDSGGLKASTELQVNI 226 + FR++A G +F+ L ++ SF + R L + T + +NI Sbjct: 2914 QSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINI 2973 Query: 227 VNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FM 284 V+ ND P+F V + + GT + +TA D D G S + Y I+ + F Sbjct: 2974 VDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFK 3033 Query: 285 INQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPAT 344 ++ TG I VA + D L QN I++ K P + + IT + E+ P Sbjct: 3034 LDNDTGWISVASSLISD---LNQNFFITVTAKDKGNPPLSSQATVHIT-VTEENYHTPEF 3089 Query: 345 CQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGS 404 Q S +PE + G+++ ++ D A N +++ SG G + + + Sbjct: 3090 SQSH-MSATIPESHSIGSIVRTVSA---RDRDAAMNGLIKYSISSGNEEGIFAIN--SST 3143 Query: 405 GKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP 464 G + L LDYE K+ + I D V + N+ +F Sbjct: 3144 GILTLAKALDYE------LCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSD 3197 Query: 465 SYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQL 523 Y V E P+ T V + ATD D ++++ Y++ + + L F I+P TG + Sbjct: 3198 DYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDL-----FVIDPNTGVITT 3252 Query: 524 VTKVDCETTPIYILRIQATN---NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLK 580 +D ET Y L ++A N E S TV + + N+ P Y+ + Sbjct: 3253 QGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAP 3312 Query: 581 VGT 583 GT Sbjct: 3313 KGT 3315 Score = 87.8 bits (216), Expect = 4e-17 Identities = 105/433 (24%), Positives = 177/433 (40%), Gaps = 50/433 (11%) Query: 239 PTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRI 298 P +V+ VLEE PGT+V I GF Y ++ F IN TG + I Sbjct: 45 PRQVFQVLEEQPPGTLVGTIQTR----PGF----TYRLSESHALFAINSSTGALYTTSTI 96 Query: 299 DRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERT 358 DR E + I+L VL Y ++ +V D+NDN + + E + Sbjct: 97 DR---ESLPSDVINLVVLSSAPTY-----PTEVRVLVRDLNDNAPVFPDPSIVVTFKEDS 148 Query: 359 AKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQD----PAGSG---KIVLIG 411 + G ++ D S ++R ++ + G +G RF D P+G G +V G Sbjct: 149 SSGRQVILDTATDSDIGSNGVDHR-SYRIIRGNEAG-RFRLDITLNPSGEGAFLHLVSKG 206 Query: 412 DLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVS 471 LD E +Y ++++V+D P + + V + N+ P +F Y V Sbjct: 207 GLDRE------VTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVP 260 Query: 472 ERRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCE 530 E + V QV A D D + + Y + G Q ++P+TG + + +D E Sbjct: 261 EDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQ------MDPETGLITVREPLDFE 314 Query: 531 TTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPIC-----TPNSYFLALPVDLKVG 582 Y L +QA + T + +L+ ND P+ S + ++ + +VG Sbjct: 315 ARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVG 374 Query: 583 TNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDK 642 T + +T D ++ + I GN HF + N++ + + S D ++ Sbjct: 375 TVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDR----ER 430 Query: 643 IWDYKLLVYVTDD 655 I Y L V V+D+ Sbjct: 431 IPSYNLTVSVSDN 443 Score = 84.0 bits (206), Expect = 6e-16 Identities = 110/465 (23%), Positives = 187/465 (40%), Gaps = 45/465 (9%) Query: 184 SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVY 243 S+ G L++T+ +D E+ +V + S TE++V + +LND P F P+ V Sbjct: 85 SSTGALYTTSTIDRESLPSDVINLVVL--SSAPTYPTEVRVLVRDLNDNAPVFPDPSIVV 142 Query: 244 TVLEELSPGTIVANITAEDPD-DEGFPSHLLYSITTVSK--YFMIN---QLTGTIQVAQR 297 T E+ S G V TA D D H Y I ++ F ++ +G Sbjct: 143 TFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHL 202 Query: 298 IDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPER 357 + + + P L V V+D+ + +Q+ V+D+NDNP + VPE Sbjct: 203 VSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPED 262 Query: 358 TAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYEN 417 G+ +L + D E N + + G+ F DP +G I + LD+E Sbjct: 263 AVVGSSVLQV---AAADADEGTNADIRYRLQD---EGTPFQMDPE-TGLITVREPLDFE- 314 Query: 418 PSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYI-LTSPENEFPLI----FDRPSYVFDVSE 472 A +Y++ +Q D P I L + P++ F S V E Sbjct: 315 -----ARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDE 369 Query: 473 RRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWIN----PKTGELQLVTKVD 528 T V + TD D P ++ S+ G + Q F + P +++ + +D Sbjct: 370 NAQVGTVVALLTVTDADSPAANGNISVQILGGNEQ--RHFEVQSSKVPNLSLIKVASALD 427 Query: 529 CETTPIYILRIQATNN----------EDTSSVTVTVNILEENDEKPICTPNSYFLALPVD 578 E P Y L + ++N +S ++ + + + ND P+ + Y + L + Sbjct: 428 RERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEE 487 Query: 579 LKVGTNIQNFKLTCTDLDSS-PRSFRYSIGPGNVNNHFTFSPNAG 622 G+ + ++ TD DS + RYSI GN F S ++G Sbjct: 488 APPGSYVSG--ISATDGDSGLNANLRYSIVSGNGLGWFHISEHSG 530 Score = 67.4 bits (163), Expect = 6e-11 Identities = 89/308 (28%), Positives = 137/308 (44%), Gaps = 37/308 (12%) Query: 62 IVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKD--EVGVTDLQVL 119 ++ N + F++N +G ++ +G+ LD E + L++ K+ + D+ + Sbjct: 3336 LIFGNSRKKGFQINKKTG---QIYVSGI--LDREKEERV-SLKVLAKNFGSIRGADIDEV 3389 Query: 120 TVQVT--DVNEPPQFQGNLAEGLHLYIVERANPG-FIYQVEAFDPEDTSRNIPLSYFLIS 176 TV VT D N+PP F N+ + I E G + V AFD + SYF+ S Sbjct: 3390 TVNVTVLDANDPPIFTLNIYS---VQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGS 3446 Query: 177 PPKSFRMSAN---GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKA--STELQVNIVNLND 231 ++ S N G + T ELD E ++L V DSG A S L V + ++ND Sbjct: 3447 GNENGAFSINPQTGQITVTAELDRET-LPIYNLSVLAVDSGTPSATGSASLLVTLEDIND 3505 Query: 232 EVPRFTSPTRVYTVLEELSPGTIVANITAEDPD---DEGFPSHLLYSITTVSKYFMINQL 288 P T V+E PGT+V + + DPD ++G ++ L S + YF ++ Sbjct: 3506 NGPMLTVSEG--EVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLS-T 3562 Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDR--PYGGQENRIQITFIVEDVNDNPATCQ 346 G + + IDR+ Q L V+ KD P + IT I D NDNP+ Q Sbjct: 3563 AGVLSTTREIDRE-----QIADFYLSVVTKDSGVPQMSSTGTVHITVI--DQNDNPS--Q 3613 Query: 347 KFTFSIMV 354 T I V Sbjct: 3614 SRTVEIFV 3621 Score = 58.9 bits (141), Expect = 2e-08 Identities = 65/242 (26%), Positives = 111/242 (45%), Gaps = 20/242 (8%) Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90 ++E P GT V S S S+ P F + S AF +N +G ++ T Sbjct: 3413 ISEGVPIGTHVTFVSAFDSDSI-PSWSRFSYFIGSGNENGAFSINPQTG---QITVTA-- 3466 Query: 91 QLDFETGPNIFDLQIYVKDE--VGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERA 148 +LD ET P I++L + D T L V + D+N+ ++EG ++E Sbjct: 3467 ELDRETLP-IYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPML-TVSEG---EVMENK 3521 Query: 149 NPG-FIYQVEAFDPEDTSRNIPLSYFLIS--PPKS-FRMSANGTLFSTTELDFEAGHRSF 204 PG + +++ DP+ P +Y+L+S P S F +S G L +T E+D E F Sbjct: 3522 RPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQ-IADF 3580 Query: 205 HLIVEVRDSG--GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAED 262 +L V +DSG + ++ + + +++ ND + + L PG I+ ++ +D Sbjct: 3581 YLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQD 3640 Query: 263 PD 264 PD Sbjct: 3641 PD 3642 >gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] Length = 3354 Score = 130 bits (328), Expect = 4e-30 Identities = 163/617 (26%), Positives = 258/617 (41%), Gaps = 61/617 (9%) Query: 23 ILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYF 82 I LP + N+ E+SPPGT+V + P G + S F ++++SG Sbjct: 237 INLPYSTNIYEHSPPGTTVRIITAIDQDKGRP--RGIGYTIVSGNTNSIFALDYISGVLT 294 Query: 83 EVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT---VQVTDVNE-PPQFQGNLAE 138 E + G + + D+ +D V T + V D+N+ P+F + Sbjct: 295 LNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFN---SS 351 Query: 139 GLHLYIVERANPGFIYQVEAFDPEDTSRNIPL------------SYFLISPPKSFRMSAN 186 + I E A GF + D N+ L S+ I P S + A+ Sbjct: 352 EYSVAITELAQVGFALPL-FIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKAD 410 Query: 187 GTLFSTTELDFEAGHR-SFHLIV--EVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVY 243 + LD+E R F L V D G ++++ ++N ND P F+ P Sbjct: 411 IRIRVAIPLDYETVDRYDFDLFANESVPDHVGY---AKVKITLINENDNRPIFSQPLYNI 467 Query: 244 TVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAG 303 ++ E ++ GT V + A D +D G + Y + F +++ TG I + R+D Sbjct: 468 SLYENVTVGTSVLTVLATD-NDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDY--- 523 Query: 304 ELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTL 363 EL Q T+++ R GG+E ++ V DVNDN T QK + + E T Sbjct: 524 ELIQRFTLTIIA----RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ 579 Query: 364 LLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRF-LQDPAGSGKIVLIGDLDYENPSNLA 422 L+ L D+ PNN+ +++ S GS F + G G I + LDYE SN Sbjct: 580 LVRLRA---TDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISN-- 634 Query: 423 AGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQ 482 G Y + + D P + V V I EN+ P F +P+Y V E A V Sbjct: 635 -GLIY-LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLF 692 Query: 483 VRATD----KDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILR 538 + ATD ++ Q S++Y SL+ F IN ++GE+ + +D ET YIL Sbjct: 693 LNATDLDRSREYGQESIIY-------SLEGSTQFRINARSGEITTTSLLDRETKSEYILI 745 Query: 539 IQAT-----NNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCT 593 ++A +N+ T TV + +L+ ND P Y++ L +++ Sbjct: 746 VRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP 805 Query: 594 DLDSSPRSFRYSIGPGN 610 DL + + YSI P N Sbjct: 806 DLGEN-GTLVYSIQPPN 821 Score = 125 bits (315), Expect = 1e-28 Identities = 162/630 (25%), Positives = 262/630 (41%), Gaps = 64/630 (10%) Query: 28 TGNVAENSPPGTSVHKFSV---KLSASLSPVIPGFPQIVNSNPLT----EAFRVNWLSGT 80 T +V E++ PGT + + L+ L I G +++ L +AF VN +G+ Sbjct: 2180 TVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239 Query: 81 YFEVVTTGMEQL-DFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAE 138 E + +E ++ D + + LTV V DVN+ PQF+ Sbjct: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFK---PF 2296 Query: 139 GLHLY---IVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS--PPKSFRM--SANGTLF 190 G+ Y I+E A PG + V A DP D N ++Y L+ PP ++ S+ G + Sbjct: 2297 GITYYMERILEGATPGTTLIAVAAVDP-DKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVI 2355 Query: 191 STTELDFEAGHRSFHLIVEVRDSGGLKASTELQV--NIVNLNDEVPRFTSPTRVYTVLEE 248 + +D+E H + V D+G + E+ V IV++ND P F P+ V E+ Sbjct: 2356 ANRTVDYEEVHW-LNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFED 2414 Query: 249 LSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQN 308 + GTI+ +TA D D F + + YS+ F IN TG I V +DR+ + Sbjct: 2415 VPVGTIILTVTATDADSGNF-ALIEYSLGDGESKFAINPTTGDIYVLSSLDRE-----KK 2468 Query: 309 PTISLEVLVKDRP----YGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLL 364 L L KD P +EN +Q+ V DVND K FS V E GT + Sbjct: 2469 DHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSV 2528 Query: 365 LDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAG 424 + + D E PN +++ G G SG + + P L + Sbjct: 2529 ITMMA---TDQDEGPNGELTYSLE---GPGVEAFHVDMDSGLVTT------QRP--LQSY 2574 Query: 425 NKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP--SYVFDVSERRPARTRVGQ 482 K+++ + D P + + N+ +F RP + + E P R+ V + Sbjct: 2575 EKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE 2634 Query: 483 VRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA 541 V ATDKD ++ YS + + F I+P +G +Q ++D E+ +Y L + A Sbjct: 2635 VYATDKDEGLNGAVRYSFLKTAGNRDW-EFFIIDPISGLIQTAQRLDRESQAVYSLILVA 2693 Query: 542 TN------NEDTSSVTVTVNILEEND----EKPICTPNSYFLALPVDLKVGTNIQNFKLT 591 ++ E + V + +++N+ P +P L +P GT + N Sbjct: 2694 SDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNV-TG 2752 Query: 592 CTDLDSSPRSF-RYSIGPGNVNNHFTFSPN 620 D D P + Y I GN +F P+ Sbjct: 2753 AVDADEGPNAIVYYFIAAGNEEKNFHLQPD 2782 Score = 117 bits (294), Expect = 4e-26 Identities = 161/606 (26%), Positives = 248/606 (40%), Gaps = 81/606 (13%) Query: 98 PNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGF-IYQ 155 P I +L + +D + L + + D N+ P F L ++++E PGF + Q Sbjct: 2034 PPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS---PATLTVHLLENCPPGFSVLQ 2090 Query: 156 VEAFDPEDTSRNIPLSY---------FLISPPKSFRMSANGTLFSTTELDFEAGHRSFHL 206 V A D ED+ N L Y FLI N T+ + S+ L Sbjct: 2091 VTATD-EDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQ-------ESYRL 2142 Query: 207 IVEVRDSGGLKASTELQVNIV--NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPD 264 V D G + S V I+ ++ND P F +P + +VLE PGT++ANITA D D Sbjct: 2143 TVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD 2202 Query: 265 DEGFPSHLLYSITTVSK------------YFMINQLTGTIQVAQRIDRDAGELRQNPTIS 312 P + + V+K F +N TG++ V ++R EL ++ Sbjct: 2203 LN--PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNR---ELVATYEVT 2257 Query: 313 LEVL--VKDRPYGG-QENRIQITFIVEDVNDNPATCQKFTFSI---MVPERTAKGTLLLD 366 L V+ D P ++T V DVNDN + F + + E GT L+ Sbjct: 2258 LSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIA 2317 Query: 367 LNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNK 426 + D + N +T+ V G L+D + +GK++ +DYE L Sbjct: 2318 VAAV---DPDKGLNGLVTYTLLDLVPPGYVQLED-SSAGKVIANRTVDYEEVHWL----- 2368 Query: 427 YTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRAT 486 ++ D P + VY+ N+ IFD+PSY V E P T + V AT Sbjct: 2369 -NFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTAT 2427 Query: 487 DKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA---- 541 D D +L+ YS+ G + F INP TG++ +++ +D E YIL A Sbjct: 2428 DADSGNFALIEYSLGDGESK------FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 2481 Query: 542 ---TNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSS 598 +N +SV V + +L+ ND +P + + ++ + GT++ + TD D Sbjct: 2482 GDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSV--ITMMATDQDEG 2539 Query: 599 PR-SFRYSI-GPGNVNNHFTFSPNAGSNVTRLLLTSRFDYA-----GGFDKIW-DYKLLV 650 P YS+ GPG H + L +F GG +W LLV Sbjct: 2540 PNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLV 2599 Query: 651 YVTDDN 656 V D N Sbjct: 2600 EVIDVN 2605 Score = 114 bits (284), Expect = 5e-25 Identities = 166/666 (24%), Positives = 262/666 (39%), Gaps = 69/666 (10%) Query: 29 GNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEV---- 84 G + EN P T + V+L A+ P QI S AF G+YF++ Sbjct: 568 GALRENEPSVTQL----VRLRATDEDSPPN-NQITYSIVSASAF------GSYFDISLYE 616 Query: 85 ---VTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQV---LTVQVTDVNE-PPQFQGNLA 137 V + LD+E N + + G L +T++V D N+ PP F Sbjct: 617 GYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFS---K 673 Query: 138 EGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS--FRMSANGTLFSTTEL 195 + +VE G D SR + S S FR++A +TT L Sbjct: 674 PAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSL 733 Query: 196 DFEAGHRSFHLIVEVRDSG-GLKASTEL---QVNIVNLNDEVPRFTSPTRVYTVLEELSP 251 + LIV D G G T + + ++++ND P + ++E P Sbjct: 734 LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793 Query: 252 GTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQR-IDR---DAGELRQ 307 + V + A DPD G L+YSI +K++ +N TG I+ +DR D E Sbjct: 794 DSDVTTVVAVDPD-LGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAEL 852 Query: 308 NPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDL 367 I + V RP + + + D+NDN T Q F V E G + + Sbjct: 853 MRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQV 912 Query: 368 NKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKY 427 D E N ++ MP G+ + + SG +V +LD E + +Y Sbjct: 913 VAIDLD---EGLNGLVSYRMPVGMPRMDFLIN--SSSGVVVTTTELDRERIA------EY 961 Query: 428 TVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATD 487 + + D P + + I N+ F Y VSE P RV + TD Sbjct: 962 QLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTD 1021 Query: 488 KDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--- 544 D+ ++ L TGG F + + ++ V +D ETT Y+L ++A +N Sbjct: 1022 NDVGLNAELSYFITGG---NVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPV 1078 Query: 545 --EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSF 602 T + TV V +L+ ND +PI +SY ++P D+ G +I K T D R + Sbjct: 1079 GKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVW 1138 Query: 603 RYSIGPGNVNNHFTFSPNAG------------SNVTRLLLTSRFDYAGGFDKIWDYKLLV 650 Y I GN N+F + G N + +L+ +++ G + +++V Sbjct: 1139 -YRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRS-SVRVIV 1196 Query: 651 YVTDDN 656 YV D N Sbjct: 1197 YVEDIN 1202 Score = 112 bits (279), Expect = 2e-24 Identities = 169/702 (24%), Positives = 288/702 (41%), Gaps = 106/702 (15%) Query: 30 NVAENSPP-GTSVHKFSVKLSASLSPVIPGFPQIVNSNP---LTEAFRVNWLSGT--YFE 83 ++ +N+P +S + ++ A + +P F Q+V+ + L F V + +F Sbjct: 340 DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFI 399 Query: 84 VVTTGME-----------QLDFETGPNIFDLQIY----VKDEVGVTDLQVLTVQVTDVNE 128 + T ++ LD+ET +D ++ V D VG +++ + D Sbjct: 400 ISPTSVQGKADIRIRVAIPLDYETVDR-YDFDLFANESVPDHVGYAKVKITLINEND--N 456 Query: 129 PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN-G 187 P F L ++ + E G D +SYF P F + + G Sbjct: 457 RPIFSQPL---YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 513 Query: 188 TLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLE 247 + LD+E R F L + RD GG + + +++N++++ND VP F V + E Sbjct: 514 LIMLIARLDYELIQR-FTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRE 572 Query: 248 ELSPGTIVANITAEDPDDEGFPSHLLYSITTVS---KYFMIN--QLTGTIQVAQRIDRDA 302 T + + A D +D + + YSI + S YF I+ + G I V++ +D Sbjct: 573 NEPSVTQLVRLRATD-EDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDY-- 629 Query: 303 GELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGT 362 E N I L V+ D + + +T V D NDNP T K + + V E G Sbjct: 630 -EQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGA 688 Query: 363 LLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLA 422 +L LN D E +++ GS + A SG+I LD E S Sbjct: 689 TVLFLNATDLDRSREYGQESIIYSL-----EGSTQFRINARSGEITTTSLLDRETKS--- 740 Query: 423 AGNKYTVIIQVQDVAPPYYKN----NVYVYILTSPENEFPLIFDRPSYVFDVSERRPART 478 +Y +I++ D + + V + +L +N P D P Y+ ++ E P + Sbjct: 741 ---EYILIVRAVDGGVGHNQKTGIATVNITLLDINDNH-PTWKDAPYYI-NLVEMTPPDS 795 Query: 479 RVGQVRATDKDLPQS-SLLYSI-----------STGGASLQYPNVFWINPKTGELQLVTK 526 V V A D DL ++ +L+YSI +TG + + NP E +L+ K Sbjct: 796 DVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK 855 Query: 527 V-----DCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKV 581 + DC P+ + TSS TV VN+L+ ND P + + + Sbjct: 856 IVVSVTDCGRPPL----------KATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905 Query: 582 GTNIQNFKLTCTDLDSSPR---SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAG 638 G +I +++ DLD S+R +G ++ F N+ S V ++ T+ D Sbjct: 906 GVSI--YQVVAIDLDEGLNGLVSYRMPVGMPRMD----FLINSSSGV--VVTTTELDR-- 955 Query: 639 GFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVI 680 ++I +Y+L V +D A ++ T TL+I V+ Sbjct: 956 --ERIAEYQLRVVASD---------AGTPTKSSTSTLTIHVL 986 Score = 88.2 bits (217), Expect = 3e-17 Identities = 127/540 (23%), Positives = 221/540 (40%), Gaps = 66/540 (12%) Query: 185 ANGTLFSTTELDFEAGHRSFHLIVEVRDSGGL--KASTELQVNIVNLNDEVPRFTSPTRV 242 + G + + LD+E S+ + V D + + + ++N DE +F++ + Sbjct: 1261 STGLIITVNYLDYET-KTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYE 1319 Query: 243 YTVLEELSPGTIVANITAEDPDDEGFPSHLL--YSITTVSKYFMINQLTGTIQVAQRIDR 300 +LE L+ GT + + A D+ ++ Y+ T F I+ +TG I V +DR Sbjct: 1320 AAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDR 1379 Query: 301 DAGELRQNPTISLEVLVKDRPYGGQ--ENRIQITFIVEDVNDNPATCQKFTFS----IMV 354 + G+ +L V+ D GG ++ +++ V D NDN +F F+ + + Sbjct: 1380 EKGDF-----YTLTVVADD---GGPKVDSTVKVYITVLDENDNSP---RFDFTSDSAVSI 1428 Query: 355 PERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVL----I 410 PE G + + + D N + F++ SG + AG+ +IV I Sbjct: 1429 PEDCPVGQRVATVKAW---DPDAGSNGQVVFSLASG---------NIAGAFEIVTTNDSI 1476 Query: 411 GDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP-SYVFD 469 G++ P + + Y + + D P K + + + N+ P + + P Y Sbjct: 1477 GEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVS 1536 Query: 470 VSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQL-VTKV 527 V+E T V QVRATD+D+ +S+L Y I+ G + F ++ +GE+ Sbjct: 1537 VNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDM----AFRMDRISGEIATRPAPP 1592 Query: 528 DCETTPIYILRIQATNNEDTSSVTVT----VNILEENDEKPICTPNSYFLALPVDLKVGT 583 D E Y L + +E T +++ T V I++END P+ Y + L Sbjct: 1593 DRERQSFYHL-VATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDT-L 1650 Query: 584 NIQNFKLTCTDLDSSPR-SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDK 642 N + DLD P + Y+I GN+ N F + G + DY + Sbjct: 1651 NTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV----ITAAKELDYEISHGR 1706 Query: 643 IWDYKLLVYVTDD-NLMSDR--KKAEALVETGTVTLSIKVIPH----PTTIITTTPRPRV 695 Y L+V TD ++S R LV + ++ P P + P PRV Sbjct: 1707 ---YTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRV 1763 Score = 85.5 bits (210), Expect = 2e-16 Identities = 137/551 (24%), Positives = 232/551 (42%), Gaps = 51/551 (9%) Query: 71 AFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE-- 128 AFR++ +SG + T D E + + L V+DE T V VT V+E Sbjct: 1575 AFRMDRISGE----IATRPAPPDRER-QSFYHLVATVEDEGTPTLSATTHVYVTIVDEND 1629 Query: 129 -PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPP--KSFRMSA 185 P FQ E L + N I ++A D D N ++Y +++ +FR+ Sbjct: 1630 NAPMFQQPHYEVLLDEGPDTLNTSLI-TIQALDL-DEGPNGTVTYAIVAGNIVNTFRIDR 1687 Query: 186 N-GTLFSTTELDFEAGHRSFHLIVEVRD-----SGGLKASTELQVNIVNLNDEVPRFTSP 239 + G + + ELD+E H + LIV D S L ++T + VN+ ++ND VP F Sbjct: 1688 HMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRD 1747 Query: 240 TRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FMINQLTGTIQVAQR 297 + E PG V A D D G + YSI F+I+ + G ++V + Sbjct: 1748 YEGPFEVTEGQPGPRVWTFLAHD-RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKD 1806 Query: 298 IDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPER 357 ++ D + +L + +DR + + + V D+NDN +I + E Sbjct: 1807 VELDRETI---AFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISEN 1863 Query: 358 TAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYEN 417 + + + + D DS N R F + +G + F+ A +G + + LD E Sbjct: 1864 SPVSSFVAHV--LASDADSGC-NARLTFNITAGNRERAFFIN--ATTGIVTVNRPLDRER 1918 Query: 418 PSNLAAGNKYTVIIQVQD-VAPPYYKNNVY--VYILTSPENEFPLIFDRPSYVFDVSERR 474 +Y + I V+D P Y + I S EN+ +F + +Y +V E Sbjct: 1919 IP------EYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENS 1972 Query: 475 PARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKV----DCE 530 PA T + + L +Y++ T +F IN TG + + + V + Sbjct: 1973 PAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAF 2032 Query: 531 TTPIYILRIQATNNED----TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586 + PI L + A ED S+ + + IL++ND +P +P + + L + G ++ Sbjct: 2033 SPPILELLLLA---EDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV- 2088 Query: 587 NFKLTCTDLDS 597 ++T TD DS Sbjct: 2089 -LQVTATDEDS 2098 Score = 80.9 bits (198), Expect = 5e-15 Identities = 107/411 (26%), Positives = 180/411 (43%), Gaps = 45/411 (10%) Query: 243 YTVLEELSP-GTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRD 301 Y ++ E +P G+ V + A+D D++ P S S++F + TG + + Q +DR+ Sbjct: 39 YLLISEDTPVGSSVTQLLAQDMDND--PLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRE 96 Query: 302 AGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361 ++E V D + G R ++ V DVNDN T +S+ +PE T G Sbjct: 97 T-----KSEFTVEFSVSD--HQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVG 148 Query: 362 TLLLDLNKFCFDDDSEAPNN-RFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN 420 T + +N D D A + ++F P S+F + G + +I +LDYE Sbjct: 149 TPIFIVN--ATDPDLGAGGSVLYSFQPP------SQFFAIDSARGIVTVIRELDYET--- 197 Query: 421 LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV 480 + TV QD P I+T ++ P+ + P Y ++ E P T V Sbjct: 198 -TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP-YSTNIYEHSPPGTTV 255 Query: 481 GQVRATDKDLPQ-SSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIY---- 535 + A D+D + + Y+I +G + ++F ++ +G L L +D E P+Y Sbjct: 256 RIITAIDQDKGRPRGIGYTIVSGNTN----SIFALDYISGVLTLNGLLDRE-NPLYSHGF 310 Query: 536 ILRIQATNNED-----TSSVTVTVNIL--EENDEKPICTPNSYFLALPVDLKVGTNIQNF 588 IL ++ T D ++VT T NIL + ND P + Y +A+ +VG + F Sbjct: 311 ILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF 370 Query: 589 -KLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNA--GSNVTRLLLTSRFDY 636 ++ D + S GN ++HF SP + G R+ + DY Sbjct: 371 IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDY 421 Score = 80.5 bits (197), Expect = 6e-15 Identities = 124/551 (22%), Positives = 221/551 (40%), Gaps = 46/551 (8%) Query: 180 SFRMSANGTLFSTTELDFEAGHRSFH-LIVEV--RDSGGLKASTELQVNIVNLNDEVPRF 236 +FR+ + L + S H LIVE D G +++S + V + ++NDE P F Sbjct: 1149 NFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVF 1208 Query: 237 TSPTRVYTVLEE---LSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293 T L E + IV T D D G ++ + ++ F I++ TG I Sbjct: 1209 TQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRI--LSGAEGKFEIDESTGLII 1266 Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIM 353 +D E + + +++ + P+ + IT + E D ++ Sbjct: 1267 TVNYLDY---ETKTSYMMNVSATDQAPPFNQGFCSVYITLLNE--LDEAVQFSNASYEAA 1321 Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413 + E A GT ++ + + D+ ++ + F + + + F D A +G I + G + Sbjct: 1322 ILENLALGTEIVRVQAYSIDNLNQI---TYRFNAYTSTQAKALFKID-AITGVITVQGLV 1377 Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPS-YVFDVSE 472 D E G+ YT+ + V D P + V VYI EN+ FD S + E Sbjct: 1378 DREK------GDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPE 1430 Query: 473 RRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531 P RV V+A D D +++S+++G + + + N GE+ + +D E Sbjct: 1431 DCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAF-EIVTTNDSIGEVFVARPLDREE 1489 Query: 532 TPIYILRIQATNN---EDTSSVTVTVNILEENDEKPIC-TPNSYFLALPVDLKVGTNIQN 587 YIL++ A++ + V IL+ ND P+ +P Y +++ ++ GT + Sbjct: 1490 LDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQ 1549 Query: 588 FKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTR-------------LLLTSRF 634 + T D+ + Y I GN + F +G TR L+ T Sbjct: 1550 VRATDRDIGIN-SVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVED 1608 Query: 635 DYAGGFDKIWD-YKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPHPTTIITTTPRP 693 + Y +V D+ M + E L++ G TL+ +I + P Sbjct: 1609 EGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNG 1668 Query: 694 RVTYQVLRKNV 704 VTY ++ N+ Sbjct: 1669 TVTYAIVAGNI 1679 Score = 72.4 bits (176), Expect = 2e-12 Identities = 121/566 (21%), Positives = 220/566 (38%), Gaps = 91/566 (16%) Query: 187 GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVL 246 G ++ LD E F + V D G+ + ++ + + ++ND P F + + Sbjct: 85 GVVWLRQPLDRET-KSEFTVEFSVSDHQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIP 142 Query: 247 EELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELR 306 E GT + + A DP D G +LYS S++F I+ G + V + +D + + Sbjct: 143 ENTPVGTPIFIVNATDP-DLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAY 201 Query: 307 QNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLD 366 Q T++ K RP N + I+ DV D +S + E + GT + Sbjct: 202 Q-LTVNATDQDKTRPLSTLAN---LAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRI 257 Query: 367 LNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYEN--------- 417 + D D P +T+ SG + S F D SG + L G LD EN Sbjct: 258 IT--AIDQDKGRPRG-IGYTIVSG-NTNSIFALDYI-SGVLTLNGLLDRENPLYSHGFIL 312 Query: 418 ------------PSNLAAGNKYTV-IIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP 464 PS+ + + +I + D AP + + V I + F L P Sbjct: 313 TVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL----P 368 Query: 465 SYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGE---- 520 ++ QV D++L +S+ G S + F I+P + + Sbjct: 369 LFI--------------QVVDKDENLGLNSMFEVYLVGNNS----HHFIISPTSVQGKAD 410 Query: 521 --LQLVTKVDCETTPIYILRIQATNN--EDTSSVTVTVNILEENDEKPICTPNSYFLALP 576 +++ +D ET Y + A + + V + ++ END +PI + Y ++L Sbjct: 411 IRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLY 470 Query: 577 VDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGS---NVTRLLLTSR 633 ++ VGT++ LT D+ +F G V+ F+ P+ S + ++L +R Sbjct: 471 ENVTVGTSV----LTVLATDNDAGTF------GEVSYFFSDDPDRFSLDKDTGLIMLIAR 520 Query: 634 FDY--------------AGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKV 679 DY GG + ++ V +DN+ + +K A ++ Sbjct: 521 LDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQL 580 Query: 680 IPHPTTIITTTPRPRVTYQVLRKNVY 705 + T + P ++TY ++ + + Sbjct: 581 VRLRATDEDSPPNNQITYSIVSASAF 606 Score = 67.0 bits (162), Expect = 7e-11 Identities = 99/415 (23%), Positives = 179/415 (43%), Gaps = 63/415 (15%) Query: 119 LTVQVTDVNE------PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSY 172 + +QV DVN+ PQF ++ E E A I + +D N L+Y Sbjct: 2495 VVIQVLDVNDCRPQFSKPQFSTSVYEN------EPAGTSVITMMAT--DQDEGPNGELTY 2546 Query: 173 FLISPP-KSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNL 229 L P ++F + + L TT+ ++ + F L V D G L +T L V ++++ Sbjct: 2547 SLEGPGVEAFHVDMDSGLV-TTQRPLQS-YEKFSLTVVATDGGEPPLWGTTMLLVEVIDV 2604 Query: 230 NDEVPRFTSPTR--VYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS-----KY 282 ND P F P + + EE+ + V + A D D EG + YS + ++ Sbjct: 2605 NDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKD-EGLNGAVRYSFLKTAGNRDWEF 2663 Query: 283 FMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDN- 341 F+I+ ++G IQ AQR+DR++ + ++ + L + PY E + +ED++DN Sbjct: 2664 FIIDPISGLIQTAQRLDRESQAVYSLILVASD-LGQPVPY---ETMQPLQVALEDIDDNE 2719 Query: 342 ------PATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGS 395 P ++ + VPE + +GTL+ ++ D E PN + + +G + Sbjct: 2720 PLFVRPPKGSPQYQL-LTVPEHSPRGTLVGNVTGAV--DADEGPNAIVYYFIAAGNEEKN 2776 Query: 396 RFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV---QDVAPPYYKNNVY------ 446 LQ G ++++ DLD E + ++ I++ + PP + Sbjct: 2777 FHLQP---DGCLLVLRDLDREREA------IFSFIVKASSNRSWTPPRGPSPTLDLVADL 2827 Query: 447 ----VYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLY 497 V ++ N+ P F + Y V+ + + QV A D D+ +SL++ Sbjct: 2828 TLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882 Score = 58.2 bits (139), Expect = 3e-08 Identities = 139/596 (23%), Positives = 224/596 (37%), Gaps = 113/596 (18%) Query: 80 TYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEG 139 T ++V G QL+ + + + +EV + TV+ +D PP+ + Sbjct: 2334 TLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNF---TVRASDNGSPPR-AAEIPVY 2389 Query: 140 LHLYIVERANPGF---IYQVEAFDP--------------EDTSRNIPLSYFLISPPKSFR 182 L + + NP F YQ F+ D+ + Y L F Sbjct: 2390 LEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFA 2449 Query: 183 MS-ANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKAST------ELQVNIVNLNDEVPR 235 ++ G ++ + LD E + L +D+ G AS ++ + ++++ND P+ Sbjct: 2450 INPTTGDIYVLSSLDREKKDH-YILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQ 2508 Query: 236 FTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVA 295 F+ P +V E GT V + A D DEG L YS L G A Sbjct: 2509 FSKPQFSTSVYENEPAGTSVITMMATD-QDEGPNGELTYS------------LEGPGVEA 2555 Query: 296 QRIDRDAG------ELRQNPTISLEVLVKDRPYGGQENRIQITFI---VEDVNDNPATCQ 346 +D D+G L+ SL V+ D GG+ T + V DVNDN Sbjct: 2556 FHVDMDSGLVTTQRPLQSYEKFSLTVVATD---GGEPPLWGTTMLLVEVIDVNDNRP--- 2609 Query: 347 KFTFSIMVPERTAKGTLL-----LDLNKFCFD----DDSEAPNN--RFNFTMPSGVGSGS 395 V R GT+L + L ++ D E N R++F +G Sbjct: 2610 -------VFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWE 2662 Query: 396 RFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY-YKNNVYVYILTSPE 454 F+ DP SG I LD E+ + Y++I+ D+ P Y+ + + Sbjct: 2663 FFIIDPI-SGLIQTAQRLDRESQA------VYSLILVASDLGQPVPYETMQPLQVALEDI 2715 Query: 455 NEFPLIFDRPS------YVFDVSERRPARTRVGQVR-ATDKDL-PQSSLLYSISTGGASL 506 ++ +F RP + V E P T VG V A D D P + + Y I+ G Sbjct: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEK 2775 Query: 507 QYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNE----------------DTSSV 550 F + P G L ++ +D E I+ ++A++N D + Sbjct: 2776 N----FHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQ 2830 Query: 551 TVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSI 606 V V + + ND+ P T Y + D KVG+ + D+ ++ F YSI Sbjct: 2831 EVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF-YSI 2885 >gi|203097724 cadherin-like 29 [Homo sapiens] Length = 788 Score = 127 bits (320), Expect = 3e-29 Identities = 200/852 (23%), Positives = 329/852 (38%), Gaps = 120/852 (14%) Query: 5 IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSA-SLSPVIPGFPQIV 63 ++LL LL + L LP NV+E+ PGT + S S+ + +P + +++ Sbjct: 1 MVLLRLLVFLFAPVVSDLCSLPCFINVSESQGPGTVLQFLSFNCSSYTPTPTL----ELL 56 Query: 64 NSNPLTEAFRVNWLS---GTYFEVVTTGME-------------QLDFETGPNIFDLQIYV 107 N P T F L+ GTY +T QL F G ++ + + V Sbjct: 57 NVQPPTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSV 116 Query: 108 KDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIY---QVEAFDPEDT 164 + ++ +Q + E Q + G LY + PG Q+ +D Sbjct: 117 DVQRDLSHIQCAGQFASPAGEMIQVPETVTPGARLYTL--LLPGLELHGAQMSIISAQD- 173 Query: 165 SRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQV 224 L +F P F ++ G L + ++ + F L + V + V Sbjct: 174 -----LPHF----PGPFSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIV 224 Query: 225 NIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTV--SKY 282 ++ + F + T+ E L+PG+ V + A D L Y I + S Sbjct: 225 KVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD-------LRYEILSPVPSPL 277 Query: 283 FMINQLTGTIQVAQRID--RDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVND 340 F I + G ++ ++ R +G L+V ++ ++ +T V+ VN Sbjct: 278 FSIGRADGVVRTTTPLELARTSG----TAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNL 333 Query: 341 NPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQD 400 P C +PE GT+L L C D DS + S S L D Sbjct: 334 WPPRCLPALLVSQIPETAPVGTVLNTLT--CEDPDSVGATLDYKLWFRSSSNPASLCLYD 391 Query: 401 PAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEF-PL 459 + + LD + P A ++ I V D P V V ++ +P NEF P Sbjct: 392 RV----LEVNATLDCDTPG---ACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPA 444 Query: 460 IFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTG 519 R F V E T +G V TD D P ++ Y S G P F ++ +G Sbjct: 445 CAPR---TFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGG------PTTFAVDRLSG 495 Query: 520 ELQLVTKVDCETTPIYILRI--------QATNNEDTSSVTVTVNILEENDEKPICTPNSY 571 E+ L+ +D E +Y L + Q N+ + S T+T+ + + ND P C P Sbjct: 496 EVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPP-- 553 Query: 572 FLALPVDLKVGTNIQNFKLTCTDLDSSPRS--FRYSIGPGNVNNHFTFSPNAGSNVTRLL 629 F L + +G +++ K++C + P+ + YSI GN N F + Sbjct: 554 FQELTIYAPLGRSVEVTKMSC-QIPQEPQRLIYSYSIVGGNSQNRFILQG--------AI 604 Query: 630 LTSRFDYAGGF--DKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPH-PTTI 686 L G F ++ Y+LL+ V D + T T+ + ++P +T+ Sbjct: 605 LVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLST-------TATIIVHLVPRRASTV 657 Query: 687 ITTTPRPRVTYQVLRKNV------YSPSAWYVPFVITLGSILLLGL---LVYLVVLLAKA 737 T+T R V + V + P W+V + G++LLL L L L+ LA+ Sbjct: 658 ATSTHRTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALLLLALGWLLGRLLQGLAQL 717 Query: 738 IHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTI--------FDGEAIDPVTGET 789 + P K + + +G + E + ++M+ FDG A D TG Sbjct: 718 LQ--APSKPAQALLLNSIQGTEGSIEGFLEAPKMEMSQAPSSVMSLHFDGRAQDSRTGRD 775 Query: 790 YEFNSKTGARKW 801 Y FN+ TGAR+W Sbjct: 776 YLFNTHTGARRW 787 >gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] Length = 790 Score = 124 bits (312), Expect = 3e-28 Identities = 122/464 (26%), Positives = 201/464 (43%), Gaps = 31/464 (6%) Query: 187 GTLFSTTELDFEAG-HRSFHL-IVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYT 244 G + ST LD E H H ++ R + L+ +E + + ++ND P+FT + T Sbjct: 108 GDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVT 167 Query: 245 VLEELSPGTIVANITAEDPDDE--GFPSHLLYSITTVSKYFMINQLTGTIQVA-QRIDRD 301 V E GT V +TA D DD G + ++YSI YF ++ TG I+ A +DR+ Sbjct: 168 VPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDRE 227 Query: 302 AGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361 A R++ ++ ++ GG + + DVNDNP + + + VPE G Sbjct: 228 A---REHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQVG 284 Query: 362 TLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNL 421 + + K +D N +++ +G G G + + K G L + P N Sbjct: 285 SA---VGKIKANDADTGSNADMTYSIINGDGMGIFSI----STDKETREGILSLKKPLNY 337 Query: 422 AAGNKYTVIIQVQDVAPPY-------YKNNVYVYILTSPENEFPLIFDRPSYVFDVSERR 474 YT+ I+ + + +K+ + I+ +E PL F PSY+ +V E Sbjct: 338 EKKKSYTLNIEGANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPL-FSMPSYLMEVYENA 396 Query: 475 PARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPI 534 T VG V A D D S + Y I+ +++ F I+ TG ++ +D E TP Sbjct: 397 KIGTVVGTVLAQDPDSTNSLVRYFIN---YNVEDDRFFNIDANTGTIRTTKVLDREETPW 453 Query: 535 YILRIQAT---NNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLT 591 Y + + A+ N + S VTV + +L+ ND P Y + + + K G I T Sbjct: 454 YNITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELA-REYDIIVCENSKPGQVIHTISAT 512 Query: 592 CTDLDSSPRSFRYSIGPG-NVNNHFTFSPNAGSNVTRLLLTSRF 634 D ++ F + + VN +FT N + + L RF Sbjct: 513 DKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRF 556 Score = 44.7 bits (104), Expect = 4e-04 Identities = 43/157 (27%), Positives = 71/157 (45%), Gaps = 12/157 (7%) Query: 115 DLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIY-QVEAFDPEDTSRNIPLSYF 173 D +L + V DV+EPP F + + E A G + V A DP+ T N + YF Sbjct: 366 DATMLKIIVGDVDEPPLFS---MPSYLMEVYENAKIGTVVGTVLAQDPDST--NSLVRYF 420 Query: 174 L---ISPPKSFRMSAN-GTLFSTTELD-FEAGHRSFHLIVEVRDSGGLKASTELQVNIVN 228 + + + F + AN GT+ +T LD E + + D+ L + + + +++ Sbjct: 421 INYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDLLSHVTVGIRVLD 480 Query: 229 LNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDD 265 +ND P + V E PG ++ I+A D DD Sbjct: 481 VNDNPPELAREYDI-IVCENSKPGQVIHTISATDKDD 516 Score = 39.3 bits (90), Expect = 0.016 Identities = 36/145 (24%), Positives = 60/145 (41%), Gaps = 16/145 (11%) Query: 486 TDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA---- 541 ++ D S+ Y ++ GA +F I+ TG++ +D E Y+L QA Sbjct: 79 SNSDKGDGSVKYILTGEGAG----TIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRR 134 Query: 542 TNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLD----S 597 TN + + + ND P T Y + +P +GT++ ++T TD D Sbjct: 135 TNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDMGTSV--LQVTATDADDPTYG 192 Query: 598 SPRSFRYSIGPGNVNNHFTFSPNAG 622 + YSI G +F+ P G Sbjct: 193 NSARVVYSILQG--QPYFSVDPKTG 215 >gi|11056063 protocadherin gamma subfamily A, 7 isoform 1 precursor [Homo sapiens] Length = 932 Score = 124 bits (310), Expect = 5e-28 Identities = 136/540 (25%), Positives = 235/540 (43%), Gaps = 57/540 (10%) Query: 69 TEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE 128 T+ F +N SG+ E++ ++ + + I ++D++ +L + V++ D+N+ Sbjct: 72 TQLFALNQRSGSLVTAGRIDREEICAQSARCLVNFNILMEDKM---NLYPIDVEIIDIND 128 Query: 129 P-PQFQGNLAEGLHLYIVERANPGFIYQV-EAFDPEDTSRNIPLSYFLISPPKSFRMSAN 186 P+F L E +++ I+E PG + + EA DP D N SY L SP + F ++ Sbjct: 129 NVPRF---LTEEINVKIMENTAPGVRFPLSEAGDP-DVGTNSLQSYQL-SPNRHFSLAVQ 183 Query: 187 G--------TLFSTTELDFEAGHRSFHLIVEVRDSGGLKAST--ELQVNIVNLNDEVPRF 236 L LD E R HL++ D G S+ +QV +V++ND P F Sbjct: 184 SGDDETKYPELVLERVLDREE-ERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVF 242 Query: 237 TSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS----KYFMINQLTGTI 292 + P TV E + GT + + A D DEG + YS ++ K F +N LTG I Sbjct: 243 SLPQYQVTVPENVPVGTRLLTVHAIDL-DEGVNGEVTYSFRKITPKLPKMFHLNSLTGEI 301 Query: 293 QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352 + +D + + +EV +D P G + ++ V DVNDN + S Sbjct: 302 STLEGLDYE-----ETAFYEMEVQAQDGP--GSLTKAKVLITVLDVNDNAPEVTMTSLSS 354 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412 +PE T GT++ F D N T+P + + + ++V + Sbjct: 355 SIPEDTPLGTVIA---LFYLQDRDSGKNGEVTCTIPENL--PFKLEKSIDNYYRLVTTKN 409 Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472 LD E S Y + ++ D P ++++ + N+ P F SY ++E Sbjct: 410 LDRETLS------LYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAE 463 Query: 473 RRPARTRVGQVRATDKDLPQSS-LLYSISTG---GASLQYPNVFWINPKTGELQLVTKVD 528 P + V A D D ++ + YS++ GA + + IN TG L + D Sbjct: 464 NNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVS--SYVSINSDTGVLYALQSFD 521 Query: 529 CETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI 585 E LR+ A ++ D +S++++++ +L++ND P + ALP D G + Sbjct: 522 YEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDN----PPEILYPALPTDGSTGMEL 577 Score = 82.8 bits (203), Expect = 1e-15 Identities = 94/391 (24%), Positives = 158/391 (40%), Gaps = 50/391 (12%) Query: 242 VYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTV-----SKYFMINQLTGTIQVAQ 296 +Y+V EE G+ V +I A+D E P L + ++ F +NQ +G++ A Sbjct: 32 LYSVSEETDKGSFVGDI-AKDLGLE--PRELAERGVRIISRGRTQLFALNQRSGSLVTAG 88 Query: 297 RIDRDAGELRQ-NPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVP 355 RIDR+ + ++ +L++D+ N I + D+NDN ++ + Sbjct: 89 RIDREEICAQSARCLVNFNILMEDKM-----NLYPIDVEIIDINDNVPRFLTEEINVKIM 143 Query: 356 ERTAKGTLLL-------DLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408 E TA G D+ +PN F+ + SG D ++V Sbjct: 144 ENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSG--------DDETKYPELV 195 Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468 L LD E + +++ D P + ++ + N+ +F P Y Sbjct: 196 LERVLDREEE------RVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV 249 Query: 469 DVSERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKV 527 V E P TR+ V A D D + YS L P +F +N TGE+ + + Sbjct: 250 TVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKL--PKMFHLNSLTGEISTLEGL 307 Query: 528 DCETTPIYILRIQATNNEDT-SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI- 585 D E T Y + +QA + + + V + +L+ ND P T S ++P D +GT I Sbjct: 308 DYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIA 367 Query: 586 ----------QNFKLTCTDLDSSPRSFRYSI 606 +N ++TCT ++ P SI Sbjct: 368 LFYLQDRDSGKNGEVTCTIPENLPFKLEKSI 398 >gi|14196477 protocadherin gamma subfamily A, 7 isoform 2 precursor [Homo sapiens] Length = 817 Score = 124 bits (310), Expect = 5e-28 Identities = 136/540 (25%), Positives = 235/540 (43%), Gaps = 57/540 (10%) Query: 69 TEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE 128 T+ F +N SG+ E++ ++ + + I ++D++ +L + V++ D+N+ Sbjct: 72 TQLFALNQRSGSLVTAGRIDREEICAQSARCLVNFNILMEDKM---NLYPIDVEIIDIND 128 Query: 129 P-PQFQGNLAEGLHLYIVERANPGFIYQV-EAFDPEDTSRNIPLSYFLISPPKSFRMSAN 186 P+F L E +++ I+E PG + + EA DP D N SY L SP + F ++ Sbjct: 129 NVPRF---LTEEINVKIMENTAPGVRFPLSEAGDP-DVGTNSLQSYQL-SPNRHFSLAVQ 183 Query: 187 G--------TLFSTTELDFEAGHRSFHLIVEVRDSGGLKAST--ELQVNIVNLNDEVPRF 236 L LD E R HL++ D G S+ +QV +V++ND P F Sbjct: 184 SGDDETKYPELVLERVLDREE-ERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVF 242 Query: 237 TSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS----KYFMINQLTGTI 292 + P TV E + GT + + A D DEG + YS ++ K F +N LTG I Sbjct: 243 SLPQYQVTVPENVPVGTRLLTVHAIDL-DEGVNGEVTYSFRKITPKLPKMFHLNSLTGEI 301 Query: 293 QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352 + +D + + +EV +D P G + ++ V DVNDN + S Sbjct: 302 STLEGLDYE-----ETAFYEMEVQAQDGP--GSLTKAKVLITVLDVNDNAPEVTMTSLSS 354 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412 +PE T GT++ F D N T+P + + + ++V + Sbjct: 355 SIPEDTPLGTVIA---LFYLQDRDSGKNGEVTCTIPENL--PFKLEKSIDNYYRLVTTKN 409 Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472 LD E S Y + ++ D P ++++ + N+ P F SY ++E Sbjct: 410 LDRETLS------LYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAE 463 Query: 473 RRPARTRVGQVRATDKDLPQSS-LLYSISTG---GASLQYPNVFWINPKTGELQLVTKVD 528 P + V A D D ++ + YS++ GA + + IN TG L + D Sbjct: 464 NNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVS--SYVSINSDTGVLYALQSFD 521 Query: 529 CETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI 585 E LR+ A ++ D +S++++++ +L++ND P + ALP D G + Sbjct: 522 YEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDN----PPEILYPALPTDGSTGMEL 577 Score = 82.8 bits (203), Expect = 1e-15 Identities = 94/391 (24%), Positives = 158/391 (40%), Gaps = 50/391 (12%) Query: 242 VYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTV-----SKYFMINQLTGTIQVAQ 296 +Y+V EE G+ V +I A+D E P L + ++ F +NQ +G++ A Sbjct: 32 LYSVSEETDKGSFVGDI-AKDLGLE--PRELAERGVRIISRGRTQLFALNQRSGSLVTAG 88 Query: 297 RIDRDAGELRQ-NPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVP 355 RIDR+ + ++ +L++D+ N I + D+NDN ++ + Sbjct: 89 RIDREEICAQSARCLVNFNILMEDKM-----NLYPIDVEIIDINDNVPRFLTEEINVKIM 143 Query: 356 ERTAKGTLLL-------DLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408 E TA G D+ +PN F+ + SG D ++V Sbjct: 144 ENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSG--------DDETKYPELV 195 Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468 L LD E + +++ D P + ++ + N+ +F P Y Sbjct: 196 LERVLDREEE------RVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV 249 Query: 469 DVSERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKV 527 V E P TR+ V A D D + YS L P +F +N TGE+ + + Sbjct: 250 TVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKL--PKMFHLNSLTGEISTLEGL 307 Query: 528 DCETTPIYILRIQATNNEDT-SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI- 585 D E T Y + +QA + + + V + +L+ ND P T S ++P D +GT I Sbjct: 308 DYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIA 367 Query: 586 ----------QNFKLTCTDLDSSPRSFRYSI 606 +N ++TCT ++ P SI Sbjct: 368 LFYLQDRDSGKNGEVTCTIPENLPFKLEKSI 398 >gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens] Length = 1955 Score = 122 bits (306), Expect = 1e-27 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%) Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77 T A+N+PP S+ +++ + P FPQ++ S ++EA RV + Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641 Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117 S TY F + TTG+ + LD E+ + T Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701 Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176 + + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L + Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758 Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233 FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D Sbjct: 759 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816 Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293 P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG + Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875 Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352 + + +D +A Q +I+ V D YG I +T IV+D+ND P K + Sbjct: 876 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402 MV KGT + + + +D++ P + F P+ + + Sbjct: 934 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983 Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462 SG+++ +L+ E P+ + + +++ D P ++ V IL E P Sbjct: 984 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037 Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522 VSE T VG + A + S++YSI +G + F IN TG + Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090 Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572 + +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150 Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630 + D ++ T++ K T D + S ++R I P F G T +L Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210 Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687 R Y +K V TDD KA+ LV + + + V P T++ Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260 Score = 111 bits (278), Expect = 3e-24 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%) Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 PG +Y + PED R F P++ +S L DF H+ F L+++ Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366 Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260 G L A L + I++ N++ P FT P+ +LE G ++ N+T+ Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426 Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314 +D +D P L+ + + F + Q +T + + Q +DR+ + T + Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480 Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373 + D G QE+ I I V D NDN T + ++ + V G ++ L D Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537 Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433 + S T VG+ F+ + +G I + ++ + G Y + +Q Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585 Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489 D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++ Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644 Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547 S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698 Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603 S+ TV + + + ND P+ P LP +L V N ++ TD D+ Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753 Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663 YS+ GN NN F + N GS T + L ++ DY LV V D + R Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800 Query: 664 AEALVETGTVTLSIKVI 680 T+TL+IKV+ Sbjct: 801 -------STLTLAIKVL 810 >gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens] Length = 1932 Score = 122 bits (306), Expect = 1e-27 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%) Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77 T A+N+PP S+ +++ + P FPQ++ S ++EA RV + Sbjct: 560 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 619 Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117 S TY F + TTG+ + LD E+ + T Sbjct: 620 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 679 Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176 + + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L + Sbjct: 680 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 736 Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233 FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D Sbjct: 737 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 794 Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293 P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG + Sbjct: 795 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 853 Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352 + + +D +A Q +I+ V D YG I +T IV+D+ND P K + Sbjct: 854 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 911 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402 MV KGT + + + +D++ P + F P+ + + Sbjct: 912 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 961 Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462 SG+++ +L+ E P+ + + +++ D P ++ V IL E P Sbjct: 962 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1015 Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522 VSE T VG + A + S++YSI +G + F IN TG + Sbjct: 1016 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1068 Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572 + +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y Sbjct: 1069 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1128 Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630 + D ++ T++ K T D + S ++R I P F G T +L Sbjct: 1129 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1188 Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687 R Y +K V TDD KA+ LV + + + V P T++ Sbjct: 1189 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238 Score = 111 bits (278), Expect = 3e-24 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%) Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 PG +Y + PED R F P++ +S L DF H+ F L+++ Sbjct: 298 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 344 Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260 G L A L + I++ N++ P FT P+ +LE G ++ N+T+ Sbjct: 345 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 404 Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314 +D +D P L+ + + F + Q +T + + Q +DR+ + T + Sbjct: 405 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 458 Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373 + D G QE+ I I V D NDN T + ++ + V G ++ L D Sbjct: 459 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515 Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433 + S T VG+ F+ + +G I + ++ + G Y + +Q Sbjct: 516 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 563 Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489 D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++ Sbjct: 564 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 622 Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547 S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T Sbjct: 623 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 676 Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603 S+ TV + + + ND P+ P LP +L V N ++ TD D+ Sbjct: 677 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 731 Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663 YS+ GN NN F + N GS T + L ++ DY LV V D + R Sbjct: 732 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 778 Query: 664 AEALVETGTVTLSIKVI 680 T+TL+IKV+ Sbjct: 779 -------STLTLAIKVL 788 >gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens] Length = 1677 Score = 122 bits (306), Expect = 1e-27 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%) Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77 T A+N+PP S+ +++ + P FPQ++ S ++EA RV + Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641 Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117 S TY F + TTG+ + LD E+ + T Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701 Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176 + + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L + Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758 Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233 FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D Sbjct: 759 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816 Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293 P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG + Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875 Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352 + + +D +A Q +I+ V D YG I +T IV+D+ND P K + Sbjct: 876 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402 MV KGT + + + +D++ P + F P+ + + Sbjct: 934 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983 Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462 SG+++ +L+ E P+ + + +++ D P ++ V IL E P Sbjct: 984 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037 Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522 VSE T VG + A + S++YSI +G + F IN TG + Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090 Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572 + +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150 Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630 + D ++ T++ K T D + S ++R I P F G T +L Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210 Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687 R Y +K V TDD KA+ LV + + + V P T++ Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260 Score = 111 bits (278), Expect = 3e-24 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%) Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 PG +Y + PED R F P++ +S L DF H+ F L+++ Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366 Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260 G L A L + I++ N++ P FT P+ +LE G ++ N+T+ Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426 Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314 +D +D P L+ + + F + Q +T + + Q +DR+ + T + Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480 Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373 + D G QE+ I I V D NDN T + ++ + V G ++ L D Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537 Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433 + S T VG+ F+ + +G I + ++ + G Y + +Q Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585 Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489 D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++ Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644 Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547 S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698 Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603 S+ TV + + + ND P+ P LP +L V N ++ TD D+ Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753 Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663 YS+ GN NN F + N GS T + L ++ DY LV V D + R Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800 Query: 664 AEALVETGTVTLSIKVI 680 T+TL+IKV+ Sbjct: 801 -------STLTLAIKVL 810 >gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens] Length = 1682 Score = 122 bits (306), Expect = 1e-27 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%) Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77 T A+N+PP S+ +++ + P FPQ++ S ++EA RV + Sbjct: 587 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 646 Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117 S TY F + TTG+ + LD E+ + T Sbjct: 647 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 706 Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176 + + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L + Sbjct: 707 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 763 Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233 FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D Sbjct: 764 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 821 Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293 P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG + Sbjct: 822 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 880 Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352 + + +D +A Q +I+ V D YG I +T IV+D+ND P K + Sbjct: 881 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 938 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402 MV KGT + + + +D++ P + F P+ + + Sbjct: 939 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 988 Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462 SG+++ +L+ E P+ + + +++ D P ++ V IL E P Sbjct: 989 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1042 Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522 VSE T VG + A + S++YSI +G + F IN TG + Sbjct: 1043 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1095 Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572 + +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y Sbjct: 1096 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1155 Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630 + D ++ T++ K T D + S ++R I P F G T +L Sbjct: 1156 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1215 Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687 R Y +K V TDD KA+ LV + + + V P T++ Sbjct: 1216 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1265 Score = 111 bits (278), Expect = 3e-24 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%) Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 PG +Y + PED R F P++ +S L DF H+ F L+++ Sbjct: 325 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 371 Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260 G L A L + I++ N++ P FT P+ +LE G ++ N+T+ Sbjct: 372 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 431 Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314 +D +D P L+ + + F + Q +T + + Q +DR+ + T + Sbjct: 432 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 485 Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373 + D G QE+ I I V D NDN T + ++ + V G ++ L D Sbjct: 486 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 542 Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433 + S T VG+ F+ + +G I + ++ + G Y + +Q Sbjct: 543 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 590 Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489 D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++ Sbjct: 591 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 649 Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547 S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T Sbjct: 650 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 703 Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603 S+ TV + + + ND P+ P LP +L V N ++ TD D+ Sbjct: 704 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 758 Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663 YS+ GN NN F + N GS T + L ++ DY LV V D + R Sbjct: 759 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 805 Query: 664 AEALVETGTVTLSIKVI 680 T+TL+IKV+ Sbjct: 806 -------STLTLAIKVL 815 >gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens] Length = 1539 Score = 122 bits (306), Expect = 1e-27 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%) Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77 T A+N+PP S+ +++ + P FPQ++ S ++EA RV + Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641 Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117 S TY F + TTG+ + LD E+ + T Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701 Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176 + + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L + Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758 Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233 FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D Sbjct: 759 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816 Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293 P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG + Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875 Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352 + + +D +A Q +I+ V D YG I +T IV+D+ND P K + Sbjct: 876 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402 MV KGT + + + +D++ P + F P+ + + Sbjct: 934 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983 Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462 SG+++ +L+ E P+ + + +++ D P ++ V IL E P Sbjct: 984 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037 Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522 VSE T VG + A + S++YSI +G + F IN TG + Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090 Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572 + +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150 Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630 + D ++ T++ K T D + S ++R I P F G T +L Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210 Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687 R Y +K V TDD KA+ LV + + + V P T++ Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260 Score = 111 bits (278), Expect = 3e-24 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%) Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 PG +Y + PED R F P++ +S L DF H+ F L+++ Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366 Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260 G L A L + I++ N++ P FT P+ +LE G ++ N+T+ Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426 Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314 +D +D P L+ + + F + Q +T + + Q +DR+ + T + Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480 Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373 + D G QE+ I I V D NDN T + ++ + V G ++ L D Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537 Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433 + S T VG+ F+ + +G I + ++ + G Y + +Q Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585 Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489 D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++ Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644 Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547 S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698 Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603 S+ TV + + + ND P+ P LP +L V N ++ TD D+ Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753 Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663 YS+ GN NN F + N GS T + L ++ DY LV V D + R Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800 Query: 664 AEALVETGTVTLSIKVI 680 T+TL+IKV+ Sbjct: 801 -------STLTLAIKVL 810 >gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens] Length = 1790 Score = 122 bits (306), Expect = 1e-27 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%) Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77 T A+N+PP S+ +++ + P FPQ++ S ++EA RV + Sbjct: 594 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 653 Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117 S TY F + TTG+ + LD E+ + T Sbjct: 654 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 713 Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176 + + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L + Sbjct: 714 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 770 Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233 FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D Sbjct: 771 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 828 Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293 P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG + Sbjct: 829 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 887 Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352 + + +D +A Q +I+ V D YG I +T IV+D+ND P K + Sbjct: 888 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 945 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402 MV KGT + + + +D++ P + F P+ + + Sbjct: 946 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 995 Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462 SG+++ +L+ E P+ + + +++ D P ++ V IL E P Sbjct: 996 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1049 Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522 VSE T VG + A + S++YSI +G + F IN TG + Sbjct: 1050 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1102 Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572 + +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y Sbjct: 1103 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1162 Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630 + D ++ T++ K T D + S ++R I P F G T +L Sbjct: 1163 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1222 Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687 R Y +K V TDD KA+ LV + + + V P T++ Sbjct: 1223 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1272 Score = 111 bits (277), Expect = 3e-24 Identities = 146/563 (25%), Positives = 233/563 (41%), Gaps = 97/563 (17%) Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 PG +Y + PED R F P++ +S L DF H+ F L+++ Sbjct: 325 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 371 Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVAN---------I 258 G L A L + I++ N++ P FT P+ +LE G +++ I Sbjct: 372 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 431 Query: 259 TAEDPDDEGFPS--------HLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQN 308 A D D E P L + + F + Q +T + + Q +DR+ + Sbjct: 432 VALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQ 486 Query: 309 PTISLEVLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDL 367 T + + D G QE+ I I V D NDN T + ++ + V G ++ L Sbjct: 487 QTYTFSITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 543 Query: 368 NKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKY 427 D+ S T VG+ F+ + +G I + ++ + G Y Sbjct: 544 TAVDADEGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTY 591 Query: 428 TVIIQVQDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQV 483 + +Q D APP + N VY+ +L P N+ P F + Y ++SE + + Sbjct: 592 ALTVQAADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 650 Query: 484 RATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN 543 +ATD++ S+ Y+I G VF ++ TG L L +D E+T YIL I A++ Sbjct: 651 QATDRE--GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASD 704 Query: 544 N--EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSS 598 + TS+ TV + + + ND P+ P LP +L V N ++ TD D+ Sbjct: 705 GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAG 759 Query: 599 PR-SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNL 657 YS+ GN NN F + N GS T + L ++ DY LV V D Sbjct: 760 INGQVHYSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGA 807 Query: 658 MSDRKKAEALVETGTVTLSIKVI 680 + R T+TL+IKV+ Sbjct: 808 VHPRH--------STLTLAIKVL 822 >gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens] Length = 1935 Score = 122 bits (306), Expect = 1e-27 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%) Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77 T A+N+PP S+ +++ + P FPQ++ S ++EA RV + Sbjct: 560 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 619 Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117 S TY F + TTG+ + LD E+ + T Sbjct: 620 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 679 Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176 + + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L + Sbjct: 680 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 736 Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233 FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D Sbjct: 737 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 794 Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293 P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG + Sbjct: 795 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 853 Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352 + + +D +A Q +I+ V D YG I +T IV+D+ND P K + Sbjct: 854 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 911 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402 MV KGT + + + +D++ P + F P+ + + Sbjct: 912 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 961 Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462 SG+++ +L+ E P+ + + +++ D P ++ V IL E P Sbjct: 962 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1015 Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522 VSE T VG + A + S++YSI +G + F IN TG + Sbjct: 1016 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1068 Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572 + +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y Sbjct: 1069 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1128 Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630 + D ++ T++ K T D + S ++R I P F G T +L Sbjct: 1129 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1188 Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687 R Y +K V TDD KA+ LV + + + V P T++ Sbjct: 1189 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238 Score = 111 bits (278), Expect = 3e-24 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%) Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 PG +Y + PED R F P++ +S L DF H+ F L+++ Sbjct: 298 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 344 Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260 G L A L + I++ N++ P FT P+ +LE G ++ N+T+ Sbjct: 345 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 404 Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314 +D +D P L+ + + F + Q +T + + Q +DR+ + T + Sbjct: 405 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 458 Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373 + D G QE+ I I V D NDN T + ++ + V G ++ L D Sbjct: 459 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515 Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433 + S T VG+ F+ + +G I + ++ + G Y + +Q Sbjct: 516 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 563 Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489 D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++ Sbjct: 564 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 622 Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547 S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T Sbjct: 623 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 676 Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603 S+ TV + + + ND P+ P LP +L V N ++ TD D+ Sbjct: 677 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 731 Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663 YS+ GN NN F + N GS T + L ++ DY LV V D + R Sbjct: 732 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 778 Query: 664 AEALVETGTVTLSIKVI 680 T+TL+IKV+ Sbjct: 779 -------STLTLAIKVL 788 >gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens] Length = 1915 Score = 122 bits (306), Expect = 1e-27 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%) Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77 T A+N+PP S+ +++ + P FPQ++ S ++EA RV + Sbjct: 545 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 604 Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117 S TY F + TTG+ + LD E+ + T Sbjct: 605 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 664 Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176 + + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L + Sbjct: 665 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 721 Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233 FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D Sbjct: 722 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 779 Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293 P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG + Sbjct: 780 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 838 Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352 + + +D +A Q +I+ V D YG I +T IV+D+ND P K + Sbjct: 839 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 896 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402 MV KGT + + + +D++ P + F P+ + + Sbjct: 897 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 946 Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462 SG+++ +L+ E P+ + + +++ D P ++ V IL E P Sbjct: 947 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1000 Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522 VSE T VG + A + S++YSI +G + F IN TG + Sbjct: 1001 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1053 Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572 + +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y Sbjct: 1054 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1113 Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630 + D ++ T++ K T D + S ++R I P F G T +L Sbjct: 1114 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1173 Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687 R Y +K V TDD KA+ LV + + + V P T++ Sbjct: 1174 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223 Score = 111 bits (278), Expect = 3e-24 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%) Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 PG +Y + PED R F P++ +S L DF H+ F L+++ Sbjct: 283 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 329 Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260 G L A L + I++ N++ P FT P+ +LE G ++ N+T+ Sbjct: 330 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 389 Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314 +D +D P L+ + + F + Q +T + + Q +DR+ + T + Sbjct: 390 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 443 Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373 + D G QE+ I I V D NDN T + ++ + V G ++ L D Sbjct: 444 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 500 Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433 + S T VG+ F+ + +G I + ++ + G Y + +Q Sbjct: 501 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 548 Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489 D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++ Sbjct: 549 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 607 Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547 S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T Sbjct: 608 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 661 Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603 S+ TV + + + ND P+ P LP +L V N ++ TD D+ Sbjct: 662 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 716 Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663 YS+ GN NN F + N GS T + L ++ DY LV V D + R Sbjct: 717 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 763 Query: 664 AEALVETGTVTLSIKVI 680 T+TL+IKV+ Sbjct: 764 -------STLTLAIKVL 773 >gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens] Length = 1952 Score = 122 bits (306), Expect = 1e-27 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%) Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77 T A+N+PP S+ +++ + P FPQ++ S ++EA RV + Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641 Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117 S TY F + TTG+ + LD E+ + T Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701 Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176 + + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L + Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758 Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233 FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D Sbjct: 759 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816 Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293 P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG + Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875 Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352 + + +D +A Q +I+ V D YG I +T IV+D+ND P K + Sbjct: 876 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402 MV KGT + + + +D++ P + F P+ + + Sbjct: 934 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983 Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462 SG+++ +L+ E P+ + + +++ D P ++ V IL E P Sbjct: 984 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037 Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522 VSE T VG + A + S++YSI +G + F IN TG + Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090 Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572 + +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150 Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630 + D ++ T++ K T D + S ++R I P F G T +L Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210 Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687 R Y +K V TDD KA+ LV + + + V P T++ Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260 Score = 111 bits (278), Expect = 3e-24 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%) Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 PG +Y + PED R F P++ +S L DF H+ F L+++ Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366 Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260 G L A L + I++ N++ P FT P+ +LE G ++ N+T+ Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426 Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314 +D +D P L+ + + F + Q +T + + Q +DR+ + T + Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480 Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373 + D G QE+ I I V D NDN T + ++ + V G ++ L D Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537 Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433 + S T VG+ F+ + +G I + ++ + G Y + +Q Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585 Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489 D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++ Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644 Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547 S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698 Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603 S+ TV + + + ND P+ P LP +L V N ++ TD D+ Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753 Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663 YS+ GN NN F + N GS T + L ++ DY LV V D + R Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800 Query: 664 AEALVETGTVTLSIKVI 680 T+TL+IKV+ Sbjct: 801 -------STLTLAIKVL 810 >gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens] Length = 1957 Score = 122 bits (306), Expect = 1e-27 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%) Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77 T A+N+PP S+ +++ + P FPQ++ S ++EA RV + Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641 Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117 S TY F + TTG+ + LD E+ + T Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701 Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176 + + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L + Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758 Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233 FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D Sbjct: 759 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816 Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293 P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG + Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875 Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352 + + +D +A Q +I+ V D YG I +T IV+D+ND P K + Sbjct: 876 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402 MV KGT + + + +D++ P + F P+ + + Sbjct: 934 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983 Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462 SG+++ +L+ E P+ + + +++ D P ++ V IL E P Sbjct: 984 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037 Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522 VSE T VG + A + S++YSI +G + F IN TG + Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090 Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572 + +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150 Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630 + D ++ T++ K T D + S ++R I P F G T +L Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210 Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687 R Y +K V TDD KA+ LV + + + V P T++ Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260 Score = 111 bits (278), Expect = 3e-24 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%) Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 PG +Y + PED R F P++ +S L DF H+ F L+++ Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366 Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260 G L A L + I++ N++ P FT P+ +LE G ++ N+T+ Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426 Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314 +D +D P L+ + + F + Q +T + + Q +DR+ + T + Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480 Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373 + D G QE+ I I V D NDN T + ++ + V G ++ L D Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537 Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433 + S T VG+ F+ + +G I + ++ + G Y + +Q Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585 Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489 D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++ Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644 Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547 S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698 Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603 S+ TV + + + ND P+ P LP +L V N ++ TD D+ Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753 Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663 YS+ GN NN F + N GS T + L ++ DY LV V D + R Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800 Query: 664 AEALVETGTVTLSIKVI 680 T+TL+IKV+ Sbjct: 801 -------STLTLAIKVL 810 >gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens] Length = 1962 Score = 122 bits (306), Expect = 1e-27 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%) Query: 28 TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77 T A+N+PP S+ +++ + P FPQ++ S ++EA RV + Sbjct: 587 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 646 Query: 78 -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117 S TY F + TTG+ + LD E+ + T Sbjct: 647 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 706 Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176 + + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L + Sbjct: 707 TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 763 Query: 177 PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233 FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D Sbjct: 764 FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 821 Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293 P FT+ T V E L GT + I A+D D S+ + S V +F ++ TG + Sbjct: 822 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 880 Query: 294 VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352 + + +D +A Q +I+ V D YG I +T IV+D+ND P K + Sbjct: 881 LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 938 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402 MV KGT + + + +D++ P + F P+ + + Sbjct: 939 MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 988 Query: 403 GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462 SG+++ +L+ E P+ + + +++ D P ++ V IL E P Sbjct: 989 DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1042 Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522 VSE T VG + A + S++YSI +G + F IN TG + Sbjct: 1043 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1095 Query: 523 LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572 + +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y Sbjct: 1096 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1155 Query: 573 LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630 + D ++ T++ K T D + S ++R I P F G T +L Sbjct: 1156 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1215 Query: 631 -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687 R Y +K V TDD KA+ LV + + + V P T++ Sbjct: 1216 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1265 Score = 111 bits (278), Expect = 3e-24 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%) Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 PG +Y + PED R F P++ +S L DF H+ F L+++ Sbjct: 325 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 371 Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260 G L A L + I++ N++ P FT P+ +LE G ++ N+T+ Sbjct: 372 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 431 Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314 +D +D P L+ + + F + Q +T + + Q +DR+ + T + Sbjct: 432 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 485 Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373 + D G QE+ I I V D NDN T + ++ + V G ++ L D Sbjct: 486 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 542 Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433 + S T VG+ F+ + +G I + ++ + G Y + +Q Sbjct: 543 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 590 Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489 D APP + N VY+ +L P N+ P F + Y ++SE + ++ATD++ Sbjct: 591 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 649 Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547 S+ Y+I G VF ++ TG L L +D E+T YIL I A++ + T Sbjct: 650 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 703 Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603 S+ TV + + + ND P+ P LP +L V N ++ TD D+ Sbjct: 704 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 758 Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663 YS+ GN NN F + N GS T + L ++ DY LV V D + R Sbjct: 759 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 805 Query: 664 AEALVETGTVTLSIKVI 680 T+TL+IKV+ Sbjct: 806 -------STLTLAIKVL 815 >gi|16933557 dachsous 1 precursor [Homo sapiens] Length = 3298 Score = 122 bits (306), Expect = 1e-27 Identities = 161/653 (24%), Positives = 269/653 (41%), Gaps = 81/653 (12%) Query: 5 IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVN 64 +I++ L G G AT + EN+PPGT + V P Sbjct: 2053 VIIVGLQGEAERGPRFPRASSEAT--IRENAPPGTPI-------------VSPRAVHAGG 2097 Query: 65 SN-PLTEAFRVNWLSGTYFEVVTTGM------EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117 +N P+T + GT+ +TG E LDFE P + + + G Sbjct: 2098 TNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRL--RLVLQAESGGAFAFT 2155 Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVE-RANPGFIYQVEAFDPEDTSRNIPLSYFLI 175 VLT+ + D N+ P+F L ++ E R G + QVEA D + S +SY L Sbjct: 2156 VLTLTLQDANDNAPRF---LRPHYVAFLPESRPLEGPLLQVEADDLDQGSGG-QISYSLA 2211 Query: 176 SPPKSFRM----SANGTLFSTTELDFEA-GHRSFHLIVEVRDSGGLKASTELQVNIVNLN 230 + + + GT+ +T LD E L+ R S L S L V +++ N Sbjct: 2212 ASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTN 2271 Query: 231 DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTG 290 D P P + V E+ G+ +A +T D D ++L S + F + + G Sbjct: 2272 DNRPTIPQPWEL-RVSEDALLGSEIAQVTGNDVDSGPVLWYVL-SPSGPQDPFSVGRYGG 2329 Query: 291 TIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTF 350 + + +D Q L++L D P+ G+ N +T +VEDVNDN + + Sbjct: 2330 RVSLTGPLD-----FEQCDRYQLQLLAHDGPHEGRAN---LTVLVEDVNDNAPAFSQSLY 2381 Query: 351 SIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLI 410 +M+ E T G+ +L ++ D DS A N ++ + S F DP ++ Sbjct: 2382 QVMLLEHTPPGSAILSVS--ATDRDSGA-NGHISYHLAS---PADGFSVDPNNGTLFTIV 2435 Query: 411 GDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDV 470 G + + + A V+++ +D P V++ +N+ F Y V Sbjct: 2436 GTVALGHDGSGAV----DVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAV 2491 Query: 471 SERRPARTRVGQVRATDKDLPQS--SLLYSISTGGASLQYPNVFWINPKTGE-------- 520 +E P + + + ATD D +S ++ YSI +G + VF + P+ E Sbjct: 2492 TEDLPPGSTLLTLEATDADGSRSHAAVDYSIISG----NWGRVFQLEPRLAEAGESAGPG 2547 Query: 521 ------LQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNSY 571 L L+ +D E+ Y L + A + +S V VTV +L+ ND P+ T SY Sbjct: 2548 PRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASY 2607 Query: 572 FLALPVDLKVGTNIQNFKLTCTDLDSSPRSF-RYSIGPGNVNNHFTFSPNAGS 623 + +P D VG + + +D D P R+++ G+ + F ++G+ Sbjct: 2608 RVTVPEDTPVGAEL--LHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGT 2658 Score = 121 bits (304), Expect = 3e-27 Identities = 149/543 (27%), Positives = 232/543 (42%), Gaps = 57/543 (10%) Query: 119 LTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176 LTV V DVN+ P F +L + + ++E PG I V A D D+ N +SY L S Sbjct: 2362 LTVLVEDVNDNAPAFSQSLYQ---VMLLEHTPPGSAILSVSATD-RDSGANGHISYHLAS 2417 Query: 177 PPKSFRMSAN-GTLFS---TTELDFEAGHRSFHLIVEVRDSG--GLKASTELQVNIVNLN 230 P F + N GTLF+ T L + G + +++E RD G G A + V + + N Sbjct: 2418 PADGFSVDPNNGTLFTIVGTVALGHD-GSGAVDVVLEARDHGAPGRAARATVHVQLQDQN 2476 Query: 231 DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS--KYFMIN-- 286 D P FT V E+L PG+ + + A D D + + YSI + + + F + Sbjct: 2477 DHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPR 2536 Query: 287 ------------QLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFI 334 + G + + + +D ++ L Q +L V DR Q + + +T Sbjct: 2537 LAEAGESAGPGPRALGCLVLLEPLDFES--LTQ---YNLTVAAADRGQPPQSSVVPVTVT 2591 Query: 335 VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSG 394 V DVNDNP + ++ + VPE T G LL + D P+ FT+ SG SG Sbjct: 2592 VLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEA---SDADPGPHGLVRFTVSSGDPSG 2648 Query: 395 SRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPE 454 L + SG + L LD E + ++ +++Q D A ++ V I Sbjct: 2649 LFELDE--SSGTLRLAHALDCETQA------RHQLVVQAADPAGAHFA-LAPVTIEVQDV 2699 Query: 455 NEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQ-SSLLYSISTGGASLQYPNVFW 513 N+ F V+E +P T V + A D D L YS+ G + F Sbjct: 2700 NDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFA 2759 Query: 514 INPKTGELQLVTKVDCETTPIYILRIQATNNEDTS-SVTVTVNILEENDEKPICTPNSYF 572 +N TGEL+ D E T + L + A + + S SVTV+V + E++ P+ ++ Sbjct: 2760 LNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFH 2819 Query: 573 LALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTS 632 +P + G ++ + + T D + YS+ T SP G N T L Sbjct: 2820 FQVPEGARRGHSLGHVQATDED-GGADGLVLYSLA--------TSSPYFGINQTTGALYL 2870 Query: 633 RFD 635 R D Sbjct: 2871 RVD 2873 Score = 108 bits (269), Expect = 3e-23 Identities = 167/672 (24%), Positives = 263/672 (39%), Gaps = 87/672 (12%) Query: 33 ENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQL 92 EN+PPGTS+ + L A+ P + Q+ +E+F ++ +G V T + L Sbjct: 1660 ENNPPGTSL----LTLRAT-DPDVGANGQVTYGGVSSESFSLDPDTG-----VLTTLRAL 1709 Query: 93 DFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGF 152 D E I +L +Y +D L +TV+V +E + L L + E +P Sbjct: 1710 DREEQEEI-NLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT 1768 Query: 153 IYQVEAFDPEDTSRNIPLSYFLIS--PPKSFRMS-ANGTLFSTTELDFEAGHRSFHLIVE 209 + + A DP D N L Y ++ P +F + A+G + LD E +F L +E Sbjct: 1769 LTMLRASDP-DVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREV-EPAFQLRIE 1826 Query: 210 VRDSG--GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEG 267 RD G L A+ L V +++ ND P F P V E++ GT++ + A DP D G Sbjct: 1827 ARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDP-DAG 1885 Query: 268 FPSHLLYSI-TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQ- 325 H+ Y + + F++ +G ++ A +DR+ Q P+ + V D G Sbjct: 1886 ANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDRE-----QCPSYTFSVSAVDGAAAGPL 1940 Query: 326 ENRIQITFIVEDVNDNPATCQKFTFSIMVPE-RTAKGTLLLDLNKFCFDDDSEAPN---- 380 + +T V DVND+ T + +P + T L L +D N Sbjct: 1941 STTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASIL 2000 Query: 381 NRFNFTMPSGVGSGS-----RFLQDPAGSG---KIVLIGDLDYENPSNLAAGNKYTVIIQ 432 R T P G S R + P G +++ I D P+ A G +I+ Sbjct: 2001 YRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATG---VIIVG 2057 Query: 433 VQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQ 492 +Q E E F R S + E P T + RA Sbjct: 2058 LQG------------------EAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTN 2099 Query: 493 SSLLYSISTGGASLQYPNVFWINPKTGELQL--VTKVDCETTPIYILRIQATNNEDTSSV 550 + YSI +G F I P TG + + +D E +P L +QA + + Sbjct: 2100 GPITYSILSGNEK----GTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT 2155 Query: 551 TVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLD-SSPRSFRYSIGPG 609 +T+ + + ND P Y LP + + ++ DLD S YS+ Sbjct: 2156 VLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPL--LQVEADDLDQGSGGQISYSLAAS 2213 Query: 610 N-VNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALV 668 F P G+ T +L +IW LV LM+ + + ALV Sbjct: 2214 QPARGLFHVDPTTGTITTTAILDR---------EIWAETRLV------LMATDRGSPALV 2258 Query: 669 ETGTVTLSIKVI 680 G+ TL++ VI Sbjct: 2259 --GSATLTVMVI 2268 Score = 106 bits (264), Expect = 1e-22 Identities = 142/560 (25%), Positives = 225/560 (40%), Gaps = 52/560 (9%) Query: 33 ENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQL 92 EN PG +++ F + P +++ P A R++ +G + L Sbjct: 1447 ENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-----SAPRGL 1501 Query: 93 DFETGPNIFDLQIYVKDEVGVTDLQVLTVQ----VTDVNE-PPQFQGNLAEGLHLYIVER 147 D ET P + L + + V VTD N+ P F A + + E Sbjct: 1502 DRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF----ASPSRVRLPED 1557 Query: 148 ANPG-FIYQVEAFDPEDTSRNIPLSYFLISPPKS-FRM-SANGTLFSTTELDFEAGHRSF 204 PG V A DP D +SY L S FR+ S+ G L LD E R+ Sbjct: 1558 QPPGPAALHVVARDP-DLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDRE--QRAE 1614 Query: 205 HLIVEVRDSGGL---KASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAE 261 H++ V G A+ L V++ ++NDE P F + E PGT + + A Sbjct: 1615 HVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRAT 1674 Query: 262 DPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRP 321 DP D G + Y + S+ F ++ TG + + +DR+ E I+L V +DR Sbjct: 1675 DP-DVGANGQVTYGGVS-SESFSLDPDTGVLTTLRALDREEQE-----EINLTVYAQDRG 1727 Query: 322 YGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNN 381 Q + + VED ND+ T S+ VPE TL + D N Sbjct: 1728 SPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM----LRASDPDVGANG 1783 Query: 382 RFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYY 441 + + + G SG+ F+ D A SG+ + LD E + + I+ +D P Sbjct: 1784 QLQYRILDGDPSGA-FVLDLA-SGEFGTMRPLDRE------VEPAFQLRIEARDGGQPAL 1835 Query: 442 KNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL-PQSSLLYSIS 500 + + + N+ F P+Y +V E PA T + Q++A D D + Y + Sbjct: 1836 SATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLG 1895 Query: 501 TGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNED----TSSVTVTVNI 556 G A F + P +GEL+ +D E P Y + A + +++V+VT+ + Sbjct: 1896 AGTA-----GAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITV 1950 Query: 557 LEENDEKPICTPNSYFLALP 576 + ND P + L LP Sbjct: 1951 RDVNDHAPTFPTSPLRLRLP 1970 Score = 87.0 bits (214), Expect = 7e-17 Identities = 136/622 (21%), Positives = 253/622 (40%), Gaps = 64/622 (10%) Query: 31 VAENSPPGTSVHK-FSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGM 89 VAEN PPGTSV + F+ + + + Q ++ + ++AFR++ +G + T Sbjct: 1114 VAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSED--SKAFRIHPQTGEVTTLQTLDR 1171 Query: 90 EQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT--DVNEPP----QFQGNLAEGLHLY 143 EQ + + L + V+D TV V D+N+ Q G GL + Sbjct: 1172 EQ------QSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQ 1225 Query: 144 IVERANPG-FIYQVEAFDPEDTSRNIPLSYFLISP-PKSFRMSANGTLFSTTELDFEAGH 201 + +R PG + ++A DP D N + Y L P + F + + T A Sbjct: 1226 VPDRVPPGTLVTTLQAKDP-DEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAER 1284 Query: 202 RSFHLIVEVRDSGGLKASTELQVNI------------VNLNDEVPRFTSP-TRVYTVLEE 248 + L + D G S LQ+ + +L + P P T E Sbjct: 1285 PHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEG 1344 Query: 249 LSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQN 308 L PG+++ ++ A +P G ++ L F ++ +G + +A+ +D +AG + Sbjct: 1345 LRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRA 1404 Query: 309 PTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLN 368 T+ E P G +++ V+D N++ + ++ +PE G L Sbjct: 1405 LTVRAE-----GPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFR 1459 Query: 369 KFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYT 428 D D PN+ + + D A +G + LD E L Sbjct: 1460 --ASDADGPGPNSDVRYRLLRQEPPVPALRLD-ARTGALSAPRGLDRETTPAL------L 1510 Query: 429 VIIQVQD---VAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRA 485 ++++ D A V + + EN+ +F PS V + E +P V A Sbjct: 1511 LLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRV-RLPEDQPPGPAALHVVA 1569 Query: 486 TDKDLPQSS-LLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN 544 D DL +++ + Y +++GG F ++ TG L +V +D E ++L + A+++ Sbjct: 1570 RDPDLGEAARVSYRLASGG-----DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDH 1624 Query: 545 ED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS 601 +++ +TV++ + NDE P Y + L + GT++ + T D+ ++ + Sbjct: 1625 GSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQ- 1683 Query: 602 FRYSIGPGNVNNH-FTFSPNAG 622 + G V++ F+ P+ G Sbjct: 1684 ----VTYGGVSSESFSLDPDTG 1701 Score = 84.3 bits (207), Expect = 4e-16 Identities = 142/634 (22%), Positives = 237/634 (37%), Gaps = 70/634 (11%) Query: 68 LTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQ---VLTVQVT 124 L +W S + T LD+E P I V + G+ L ++V + Sbjct: 512 LAPGAHTHWFSIDPTSGIITTAASLDYELEPQ--PQLIVVATDGGLPPLASSATVSVALQ 569 Query: 125 DVNE-PPQFQGNLAEGLHLYIVERANPGFIY-QVEAFDPEDTSRNIPLSYFLI------- 175 DVN+ PQFQ + + E PG + QV A D + + LSY L Sbjct: 570 DVNDNEPQFQRTF---YNASLPEGTQPGTCFLQVTATDADSGPFGL-LSYSLGAGLGSSG 625 Query: 176 SPPKSFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVP 234 SPP FR+ A+ G + +T LD + G SF V D GGLK+ ++V + + ND P Sbjct: 626 SPP--FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPP 683 Query: 235 RFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSK--YFMINQLTGTI 292 +F ++ + PGT V + A DP D+G L Y I + F +++ +G + Sbjct: 684 QFYPREYAASISAQSPPGTAVLRLRAHDP-DQGSHGRLSYHILAGNSPPLFTLDEQSGLL 742 Query: 293 QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352 VA + R R N + LE+ +D E ++ + P ++ + Sbjct: 743 TVAWPLAR-----RANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVF 797 Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412 VPE A GT + + P T+ G A SG + + Sbjct: 798 SVPEDVAPGTSVGIVQA------HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRP 851 Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472 LD E G + ++ PP + V +L N+ F P + Sbjct: 852 LDRE-----LLGPVLELEVRAGSGVPPAFA-VARVRVLLDDVNDNSPAFPAPEDTVLLPP 905 Query: 473 RRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531 T + +RA D D S + +++ GG F ++P TG ++L+ + Sbjct: 906 NTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGG-----GAFTVDPTTGHVRLMRPLGPSG 960 Query: 532 TPIYILRIQATNNEDTSSVT-----VTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586 P + L ++A + + V V + P +Y + LP GT + Sbjct: 961 GPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQV- 1019 Query: 587 NFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDY 646 ++ D P Y + ++ F P +G R L +++ Sbjct: 1020 -LQVQAQAPDGGP--ITYHLAAEGASSPFGLEPQSGWLWVRAALDRE------AQELYIL 1070 Query: 647 KLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVI 680 K++ KAE +TGT T+ + ++ Sbjct: 1071 KVMAV--------SGSKAELGQQTGTATVRVSIL 1096 Score = 83.2 bits (204), Expect = 1e-15 Identities = 115/485 (23%), Positives = 188/485 (38%), Gaps = 58/485 (11%) Query: 153 IYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSA---NGTLFSTTELDFEAGHRSFHLIVE 209 + QV+A P+ P++Y L + S +G L+ LD EA ++ Sbjct: 1019 VLQVQAQAPDGG----PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMA 1074 Query: 210 VRDS----GGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDD 265 V S G + ++V+I+N N+ PR + V E PGT V + A D D Sbjct: 1075 VSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDS 1134 Query: 266 --EGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYG 323 G ++ L ++ SK F I+ TG + Q +DR+ Q + L V V+D Sbjct: 1135 GPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDRE-----QQSSYQLLVQVQDGGSP 1189 Query: 324 GQENRIQITFIVEDVNDNPATCQKFT------FSIMVPERTAKGTLLLDLNKFCFDDDSE 377 + + V D+NDN T + + I VP+R GTL+ L D E Sbjct: 1190 PRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQA---KDPDE 1246 Query: 378 APNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVA 437 N +T+ G GS SG+++ P A Y + + D Sbjct: 1247 GENGTILYTL---TGPGSELFSLHPHSGELLTAA------PLIRAERPHYVLTLSAHDQG 1297 Query: 438 PPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD-LPQSSLL 496 P ++ + + P + + P D++ER PA + T + L SLL Sbjct: 1298 SPPRSASLQLLVQVLPSAR---LAEPPP---DLAERDPAAPVPVVLTVTAAEGLRPGSLL 1351 Query: 497 YSIS----TGGASLQYPNV--------FWINPKTGELQLVTKVDCETTPIY---ILRIQA 541 S++ G +L Y V F ++ +G L L +D E P + +R + Sbjct: 1352 GSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEG 1411 Query: 542 TNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS 601 + V V + +EN+ P + LALP + + G + F+ + D Sbjct: 1412 PGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSD 1471 Query: 602 FRYSI 606 RY + Sbjct: 1472 VRYRL 1476 Score = 82.4 bits (202), Expect = 2e-15 Identities = 163/640 (25%), Positives = 246/640 (38%), Gaps = 81/640 (12%) Query: 5 IILLALLGAM---SGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQ 61 ++LL LLGA + G+A L L + E P GT + S L A + + F Sbjct: 27 LLLLLLLGAGVPGAWGQAGSLDL-----QIDEEQPAGTLIGDISAGLPAGTAAPLMYFIS 81 Query: 62 IVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTV 121 + + ++ SG EQ D + D V +TV Sbjct: 82 AQEGSGVGTDLAIDEHSGVVRTARVLDREQRDR------YRFTAVTPDGATVE----VTV 131 Query: 122 QVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPP-- 178 +V D+N+ P F A L + E G Y +E D R Y L Sbjct: 132 RVADINDHAPAFPQARAA---LQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAG 188 Query: 179 KSFRMSA----NGT----LFSTTELDFEAGHRSFHLI-VEVRDSGG--LKASTELQVNIV 227 ++FR+ +GT L T ELD E +RS +++ +E D G +A L V ++ Sbjct: 189 ETFRLETRPGPDGTPVPELVVTGELDRE--NRSHYMLQLEAYDGGSPPRRAQALLDVTLL 246 Query: 228 NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY----F 283 ++ND P F V E L+PG+ V + A D D G + Y I F Sbjct: 247 DINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDA-DAGVNGAVTYEINRRQSEGDGPF 305 Query: 284 MINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPA 343 I+ TG +Q+ + +D Q L V +D + +T V D NDN Sbjct: 306 SIDAHTGLLQLERPLD-----FEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQP 360 Query: 344 TCQKFTFSI----MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQ 399 + S V E G L+ ++ DD A N ++ G G + Q Sbjct: 361 SMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFA---HVNVSLEGGEGHFALSTQ 417 Query: 400 DPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDV-APPYYKNNVYVYILTSPENEFP 458 D + + LD E + Y + + D +PP +V +T + P Sbjct: 418 DSV-IYLVCVARRLDREE------RDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAP 470 Query: 459 LIFDRPSYVFDVSERRPARTRVGQ--VRATDKDLPQSS---LLYSISTGGASLQYPNVFW 513 FDR Y E P G VR T +D Q + + YS++ G + + F Sbjct: 471 -AFDRQLY---RPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGA----HTHWFS 522 Query: 514 INPKTGELQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNS 570 I+P +G + +D E P L + AT+ SS TV+V + + ND +P Sbjct: 523 IDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTF 582 Query: 571 YFLALPVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGPG 609 Y +LP + GT ++T TD DS P YS+G G Sbjct: 583 YNASLPEGTQPGTCF--LQVTATDADSGPFGLLSYSLGAG 620 Score = 60.8 bits (146), Expect = 5e-09 Identities = 59/195 (30%), Positives = 89/195 (45%), Gaps = 15/195 (7%) Query: 116 LQVLTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFL 174 L +T++V DVN+ P F NL L + E PG + D L Y L Sbjct: 2689 LAPVTIEVQDVNDHGPAFPLNL---LSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSL 2745 Query: 175 ISPP------KSFRM-SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIV 227 + ++F + S+ G L + D+E SF L+V D+G L AS + V + Sbjct: 2746 LEAGPGPEGREAFALNSSTGELRARVPFDYEHTE-SFRLLVGAADAGNLSASVTVSVLVT 2804 Query: 228 NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQ 287 ++ P F +P + V E G + ++ A D +D G +LYS+ T S YF INQ Sbjct: 2805 GEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATD-EDGGADGLVLYSLATSSPYFGINQ 2863 Query: 288 LTGTIQVAQRIDRDA 302 TG + + R+D A Sbjct: 2864 TTGALYL--RVDSRA 2876 Score = 47.0 bits (110), Expect = 8e-05 Identities = 73/288 (25%), Positives = 112/288 (38%), Gaps = 30/288 (10%) Query: 89 MEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT--DVNE-PPQFQGNLAEGLHLYIV 145 +E LDFE+ ++L + D V+ V VT DVN+ PP F + + Sbjct: 2557 LEPLDFESLTQ-YNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFT---RASYRVTVP 2612 Query: 146 ERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS---PPKSFRMS-ANGTLFSTTELDFEAG 200 E G + VEA D + L F +S P F + ++GTL LD E Sbjct: 2613 EDTPVGAELLHVEASDADPGPHG--LVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQ 2670 Query: 201 HRSFHLIVEVRDSGGLK-ASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANIT 259 R L+V+ D G A + + + ++ND P F +V E PGT+V + Sbjct: 2671 ARH-QLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLH 2729 Query: 260 AEDPDDEGFPSHLLYSITTVS------KYFMINQLTGTIQVAQRIDRDAGELRQNPTISL 313 A D D F L YS+ + F +N TG ++ D + E S Sbjct: 2730 AIDGDAGAF-GRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTE-------SF 2781 Query: 314 EVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361 +LV G + ++ +V ++ F VPE +G Sbjct: 2782 RLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRG 2829 Score = 45.1 bits (105), Expect = 3e-04 Identities = 92/432 (21%), Positives = 161/432 (37%), Gaps = 55/432 (12%) Query: 218 ASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDE--GFPSHLLYS 275 A+ E+ V + ++ND P F V E + GT A D D G + L S Sbjct: 125 ATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYAL-S 183 Query: 276 ITTVSKYFMINQLTGT-------IQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENR 328 + F + G + V +DR E R + + LE P + Sbjct: 184 GDGAGETFRLETRPGPDGTPVPELVVTGELDR---ENRSHYMLQLEAYDGGSPPRRAQAL 240 Query: 329 IQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAP-NNRFNFTM 387 + +T + D+ND+ + + +V E A G+ +L + F D++A N + + Sbjct: 241 LDVTLL--DINDHAPAFNQSRYHAVVSESLAPGSPVLQV----FASDADAGVNGAVTYEI 294 Query: 388 PSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQD--VAPPYYKNNV 445 G A +G + L LD+E + +++Q +D P V Sbjct: 295 NRRQSEGDGPFSIDAHTGLLQLERPLDFEQR------RVHELVVQARDGGAHPELGSAFV 348 Query: 446 YVYILTSPENE--FPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGG 503 V++ + +N+ +IF VSE P V ++ +D D + + GG Sbjct: 349 TVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGG 408 Query: 504 ASLQYPNVFWINPKTGELQLVT---KVDCETTPIYILRIQATNNEDT---SSVTVTVNIL 557 F ++ + + LV ++D E Y LR+ AT++ + +++ Sbjct: 409 EGH-----FALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVT 463 Query: 558 EENDEKPICTPNSYF------LALPVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGPGN 610 + ND P Y +ALP V ++T D D YS+ PG Sbjct: 464 DVNDNAPAFDRQLYRPEPLPEVALPGSFVV-------RVTARDPDQGTNGQVTYSLAPGA 516 Query: 611 VNNHFTFSPNAG 622 + F+ P +G Sbjct: 517 HTHWFSIDPTSG 528 >gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens] Length = 1886 Score = 120 bits (302), Expect = 4e-27 Identities = 173/717 (24%), Positives = 293/717 (40%), Gaps = 85/717 (11%) Query: 3 EAIILLALLGAMSG--GEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP 60 +++I L + A G GE + IL+ A G+ F + + L + PG Sbjct: 526 DSVIQLTAVDADEGSNGEITYEILVGAQGD-------------FIINKTTGLITIAPGVE 572 Query: 61 QIVNSN-PLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVL 119 IV LT N + T + LD E+ + T + Sbjct: 573 MIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV 632 Query: 120 TVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPP 178 + VTDVN+ P F L L +VE F+ QV+A DP D N + Y L + Sbjct: 633 NIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGNFN 689 Query: 179 KSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEVPR 235 FR+++NG++++ +L+ E R ++ +V V G + ++ L + +++++D P Sbjct: 690 NLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV 747 Query: 236 FTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVA 295 FT+ T V E L GT + I A+D D S+ + S V +F ++ TG + + Sbjct: 748 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELSLL 806 Query: 296 QRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSIMV 354 + +D +A Q +I+ V D YG I +T IV+D+ND P K + MV Sbjct: 807 RSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 864 Query: 355 PERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPAGS 404 KGT + + + +D++ P + F P+ + + S Sbjct: 865 APDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEEDS 914 Query: 405 GKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP 464 G+++ +L+ E P+ + + +++ D P ++ V IL E P Sbjct: 915 GRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEE 968 Query: 465 SYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLV 524 VSE T VG + A + S++YSI +G + F IN TG + + Sbjct: 969 YRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIYVN 1021 Query: 525 TKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYFLA 574 +D ET Y+LR+QA + E +++ V + I +EN+ P+ Y Sbjct: 1022 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1081 Query: 575 LPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL-T 631 + D ++ T++ K T D + S ++R I P F G T +L Sbjct: 1082 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHN 1141 Query: 632 SRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687 R Y +K V TDD KA+ LV + + + V P T++ Sbjct: 1142 MRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189 Score = 84.3 bits (207), Expect = 4e-16 Identities = 129/560 (23%), Positives = 220/560 (39%), Gaps = 105/560 (18%) Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 PG +Y + PED R F P++ +S L DF H+ F L+++ Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366 Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260 G L A L + I++ N++ P FT P+ +LE G ++ N+T+ Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426 Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314 +D +D P L+ + + F + Q +T + + Q +DR+ + T + Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480 Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373 + D G QE+ I I V D NDN T + ++ + V G ++ L D Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537 Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433 + S T VG+ F+ + +G I + ++ + G Y + +Q Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585 Query: 434 QDVAPPYYKN---------------NVYVYILTSPE------------------NEFPLI 460 D APP ++ + Y+ I+T+ + N+ + Sbjct: 586 ADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 645 Query: 461 FD--RPSYVFDVSERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPK 517 FD P + V E A VGQV+ATD D + YS+ + N+F I Sbjct: 646 FDPYLPRNLSVVEEE--ANAFVGQVKATDPDAGINGQVHYSLG------NFNNLFRIT-S 696 Query: 518 TGELQLVTKVDCETTPIYILRIQATN---NEDTSSVTVTVNILEENDEKPICTPNSYFLA 574 G + K++ E Y L + AT+ + S++T+ + +L+ +D P+ T ++Y + Sbjct: 697 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 756 Query: 575 LPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRF 634 + +L GT I + DL + + Y I V + F P G L L Sbjct: 757 VEENLPAGTTILQIEAKDVDLGA---NVSYRIRSPEVKHFFALHPFTG----ELSLLRSL 809 Query: 635 DYAGGFDKIWDYKLLVYVTD 654 DY D+ LV D Sbjct: 810 DYEAFPDQEASITFLVEAFD 829 Score = 66.6 bits (161), Expect = 1e-10 Identities = 154/693 (22%), Positives = 254/693 (36%), Gaps = 113/693 (16%) Query: 101 FDLQIYVKDEVG--VTDLQVLTVQVTDVNEP------PQFQGNLAEGLHL--YIVERANP 150 FDL I + + G + L +++ D N P +QG + E + I + N Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420 Query: 151 GFIYQVEAFDPE-DTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209 ++ A D + + +++ L FL F ++ G T L Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480 Query: 210 VRDSGGLKASTELQVNI--VNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEG 267 + G++ S + VNI ++ ND P F + V ++ PG V +TA D DEG Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA-DEG 539 Query: 268 FPSHLLYSITTVSK-YFMINQLTGTIQVAQRI---------------------DRDAGEL 305 + Y I ++ F+IN+ TG I +A + +R G L Sbjct: 540 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGIL 599 Query: 306 RQNPTISLE-----VLV----KDRPYGGQENRIQITFIVEDVNDN-PATCQKFTFSIMVP 355 + E +L+ RP G + I +V DVNDN P ++ V Sbjct: 600 TLGKALDRESTDRYILIITASDGRPDGTSTATVNI--VVTDVNDNAPVFDPYLPRNLSVV 657 Query: 356 ERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDY 415 E A N F + P+ N + +G+ + +I G + Sbjct: 658 EEEA--------NAFVGQVKATDPDAGINGQVHYSLGNFNNLF-------RITSNGSIYT 702 Query: 416 ENPSNLAAGNKYTVIIQVQD--VAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473 N + Y +++ D V P + + + +L +N +F +Y V E Sbjct: 703 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS--PVFTNSTYTVLVEEN 760 Query: 474 RPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTP 533 PA T + Q+ A D DL +++ Y I S + + F ++P TGEL L+ +D E P Sbjct: 761 LPAGTTILQIEAKDVDL-GANVSYRI----RSPEVKHFFALHPFTGELSLLRSLDYEAFP 815 Query: 534 -------IYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586 + TVTV + + ND P+ + Y + D GT I Sbjct: 816 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 875 Query: 587 NFKLTCTDLDSSPRS-FRYSIG------PGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGG 639 D P S RY + P ++ F ++G +TR+ L Sbjct: 876 TVYAEDADPPGLPASRVRYRVDDVQFPYPASI---FEVEEDSGRVITRVNLNE------- 925 Query: 640 FDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQV 699 + +KL+V DD V + + T+ I V+ HP I PR T + Sbjct: 926 -EPTTIFKLVVVAFDDG---------EPVMSSSATVKILVL-HPGEI------PRFTQEE 968 Query: 700 LRKNVYSPSAWYVPFVITLGSILLLGLLVYLVV 732 R S A V + + + +VY +V Sbjct: 969 YRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1001 Score = 50.4 bits (119), Expect = 7e-06 Identities = 72/294 (24%), Positives = 114/294 (38%), Gaps = 45/294 (15%) Query: 330 QITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD----DDSEAPNNRFNF 385 ++ +V D NDN T + ++ V E T GT + F D D + PN + + Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDGPNGQIEY 189 Query: 386 TM---PSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYK 442 + P S F +G IVL L+YE+ + +Y VIIQ D A + Sbjct: 190 VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKT------RYFVIIQANDRAQNLNE 243 Query: 443 NNVYVYILT----SPENEFPLIFD----------RP-SYVFDVSERR-----------PA 476 LT ++ P+ RP +Y + E R P Sbjct: 244 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 303 Query: 477 RTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYI 536 + Q R + +LYSI G YP F ++P+T EL L+ V+ + + Sbjct: 304 IQAIDQDRNIQPPSDRPGILYSILVGTPE-DYPRFFHMHPRTAELSLLEPVNRDFHQKFD 362 Query: 537 LRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQN 587 L I+A + + + + IL+EN++ P T SY + VG I + Sbjct: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISD 416 >gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] Length = 4557 Score = 119 bits (298), Expect = 1e-26 Identities = 153/600 (25%), Positives = 254/600 (42%), Gaps = 38/600 (6%) Query: 29 GNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTG 88 GNV E+ PPG V S + I NP F + + + V Sbjct: 2931 GNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGR-FALGLVQSEWKVYVKRP 2989 Query: 89 MEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERA 148 +++ + +I+ L I D + VT V V V+DVN+ +A L + Sbjct: 2990 LDREE----QDIYFLNITATDGLFVTQAMV-EVSVSDVNDNSPVCDQVAYTALLPEDIPS 3044 Query: 149 NPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS--FRMSANGTLFSTTELDFEAGHRSFHL 206 N I +V A D D N + Y L S F +G L + LD E + L Sbjct: 3045 NK-IILKVSAKDA-DIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRER-IPVYSL 3101 Query: 207 IVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDE 266 + + D GG + + + + ++ND P F+S V E + ++ + A DPD Sbjct: 3102 MAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDI- 3160 Query: 267 GFPSHLLYSIT-TVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQ 325 G ++YS+ + F I+ +G I + Q +DR+ Q + ++ V D+ G Sbjct: 3161 GINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDRE-----QQSSYNISVRATDQSPGQS 3215 Query: 326 ENRIQ-ITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFN 384 + + +T V D+NDNP ++ + + VPE T+ GT +L + F D N Sbjct: 3216 LSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAV--FATSKDI-GTNAEIT 3272 Query: 385 FTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNN 444 + + SG G +F +P +G I + LDYE ++ ++++ +D P Sbjct: 3273 YLIRSGNEQG-KFKINPK-TGGISVSEVLDYE------LCKRFYLVVEAKDGGTPALSAV 3324 Query: 445 VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL-PQSSLLYSISTGG 503 V I + N+ P F + Y +SE V + A D D P + +SI G Sbjct: 3325 ATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGD 3384 Query: 504 ASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEEN 560 N F ++P G +++ K+D E Y L +QA ++ +S+ TV ++I + N Sbjct: 3385 RD----NEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVN 3440 Query: 561 DEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPN 620 D P+ TP +Y + + VGT+I +T D + F +SI GN F P+ Sbjct: 3441 DNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH 3500 Score = 118 bits (296), Expect = 2e-26 Identities = 112/447 (25%), Positives = 204/447 (45%), Gaps = 37/447 (8%) Query: 187 GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVL 246 GT+ LD E +++ VEV D + A T++ + +++ ND P F+ P T+ Sbjct: 1413 GTIVIAKPLDAEQ-RSIYNMSVEVTDGTNV-AVTQVFIKVLDNNDNGPEFSQPNYDVTIS 1470 Query: 247 EELSPGTIVANITAEDPDDEGFPSHLLY-SITTVS-KYFMINQLTGTIQVAQRIDRDAGE 304 E++ P T + I A D D++ S+ ++ SI ++S + F I+ TG + A+R+D +A + Sbjct: 1471 EDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQD 1530 Query: 305 LRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLL 364 L ++V+D+ + + N ++ VED ND+ + V E A G+ + Sbjct: 1531 KH-----ILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAV 1585 Query: 365 LDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAG 424 L + D + N +T+ +G +G+ F +P ++G + ++ Sbjct: 1586 LQVTAL---DKDKGENAELIYTIEAG-NTGNMFKIEP-------VLGIITICKEPDMTTM 1634 Query: 425 NKYTVIIQVQDV-APPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQV 483 ++ + I+V D +PP + +T +N P F Y +V+E T V + Sbjct: 1635 GQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPK-FIHKDYQAEVNENVDIGTSVILI 1693 Query: 484 RATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN 543 A + QS+L+Y + G + +F INP +G + +D E T Y L IQATN Sbjct: 1694 SA----ISQSTLIYEVKDGDIN----GIFTINPYSGVITTQKALDYERTSSYQLIIQATN 1745 Query: 544 NED-TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK-----LTCTDLDS 597 S+ TV + I++END P+ + Y +L + + +++ + TD DS Sbjct: 1746 MAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADS 1805 Query: 598 SPRSFR-YSIGPGNVNNHFTFSPNAGS 623 + + Y I FT + G+ Sbjct: 1806 NRNALLVYQIVESTAKKFFTVDSSTGA 1832 Score = 116 bits (290), Expect = 1e-25 Identities = 134/523 (25%), Positives = 213/523 (40%), Gaps = 48/523 (9%) Query: 90 EQLDFETGPNIFDLQIYVKDE---VGVTDLQVLTVQVTDVNE---PPQFQGNLAEGLHLY 143 ++LD+E ++L + KD+ V ++ + + V+V DVNE P F G Sbjct: 996 KELDYEK-QQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGS--- 1051 Query: 144 IVERANPGF-IYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEA 199 + E + G + QV A D ED+ R+ + Y + R S + G + + LD E Sbjct: 1052 VKENSRIGTSVLQVTARD-EDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRET 1110 Query: 200 GHRSFHLIVEVRDSG--GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVAN 257 S+ L V D G L ++ E+ + + ++ND P + P V+E V Sbjct: 1111 -MGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQ 1169 Query: 258 ITAEDPDDEGFPSHLLYSITTVS--KYFMINQLTGTIQVAQR-IDRDAGELRQNPTISLE 314 I AEDPD L Y IT+ + +F IN TG I R +DR+ Q LE Sbjct: 1170 IQAEDPDSSS-NEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDRE-----QQAEHFLE 1223 Query: 315 VLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDD 374 V V D +++ I + V D NDN + + I +PER K F FD Sbjct: 1224 VTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDR 1283 Query: 375 DSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQ 434 D E PN ++++ G G F+ G + AG+ + I+ Sbjct: 1284 D-EGPNAEISYSIVDGNDDGKFFIDPKTGM----------VSSRKQFTAGSYDILTIKAV 1332 Query: 435 DVAPPYYKNNVYVYI---LTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLP 491 D P + ++I P + PL FD P Y F V E VG V + P Sbjct: 1333 DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTP 1392 Query: 492 QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVT 551 L+ GG + + F G + + +D E IY + ++ T+ + + Sbjct: 1393 ----LWFDIVGG---NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQ 1445 Query: 552 VTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTD 594 V + +L+ ND P + +Y + + D+ T I + T D Sbjct: 1446 VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRD 1488 Score = 108 bits (270), Expect = 2e-23 Identities = 117/484 (24%), Positives = 209/484 (43%), Gaps = 35/484 (7%) Query: 118 VLTVQVTDVNEPPQFQGNLAEGLHLYIVER--ANPG-FIYQVEAFDPEDTSRNIPLSYFL 174 V+ V + D+N+ + GL Y + A PG IYQV A D +D N ++Y L Sbjct: 2069 VVRVNIEDIND----NSPVFVGLPYYAAVQVDAEPGTLIYQVTAID-KDKGPNGEVTYVL 2123 Query: 175 ISPPKSFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEV 233 F ++ N G + + + + + + + +D G ST +++ I +N + Sbjct: 2124 QDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKAM 2183 Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS--KYFMINQLTGT 291 P F P +V E++ T + +I A P+ +G ++Y I K F I+ TG Sbjct: 2184 PVFDKPFYTASVNEDIRMNTPILSINATSPEGQG----IIYIIIDGDPFKQFNIDFDTGV 2239 Query: 292 IQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFS 351 ++V +D + L + D G + + + +V DVNDNP + T++ Sbjct: 2240 LKVVSPLDYEV-----TSAYKLTIRASDALTGARAE-VTVDLLVNDVNDNPPIFDQPTYN 2293 Query: 352 IMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIG 411 + E + GT +L + D DSE N ++ + + + + + SG I+ Sbjct: 2294 TTLSEASLIGTPVLQV--VSIDADSEN-NKMVHYQIVQDTYNSTDYFHIDSSSGLILTAR 2350 Query: 412 DLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVS 471 LD+E + T+ ++ D P + V V+I S N+ P +F++ Y VS Sbjct: 2351 MLDHELVQHC------TLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVS 2404 Query: 472 ERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCE 530 E P V V+A+D D L YSI +G F ++ K+G + L Sbjct: 2405 ELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTS----FLMDSKSGVITLSNHRKQR 2460 Query: 531 TTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKL 590 P+Y L + ++ TS+ V + +L N P + ++Y + ++ GT + + + Sbjct: 2461 MEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRA 2520 Query: 591 TCTD 594 T D Sbjct: 2521 TDGD 2524 Score = 95.5 bits (236), Expect = 2e-19 Identities = 115/463 (24%), Positives = 195/463 (42%), Gaps = 50/463 (10%) Query: 185 ANGTLFSTTELDFEAG-----------HRSFHLI-VEVRDSGGLKASTE--LQVNIVNLN 230 ++G S +D E G H +L+ + + D G + S+ L +N+ + N Sbjct: 766 SDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDAN 825 Query: 231 DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTG 290 D P F + +LE GT + + A D D G + YS+ T ++ F IN TG Sbjct: 826 DNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD-LGSNGEVTYSVLTDTQQFAINSSTG 884 Query: 291 TIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQE--NRIQITFIVEDVNDNPATCQKF 348 + VA ++DR++ SL++ +D+ GQ+ + + + ++DVND Sbjct: 885 IVYVADQLDRES-----KANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPS 939 Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408 ++S+ V E GT++ L D + +++ + RF D A SG I Sbjct: 940 SYSVKVLEDLPVGTVIAWLET---HDPDLGLGGQVRYSLVNDY--NGRFEIDKA-SGAIR 993 Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNN---VYVYILTSPENEFPLIFDRPS 465 L +LDYE Y + ++ +D P ++ V V ++ EN F + Sbjct: 994 LSKELDYEKQ------QFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFA 1047 Query: 466 YVFDVSERRPARTRVGQVRATDKDLPQ-SSLLYSISTGGASLQYPNVFWINPKTGELQLV 524 V V E T V QV A D+D + + YSI G F I+ ++G + Sbjct: 1048 VVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGL----GRFSIDDESGVITAA 1103 Query: 525 TKVDCETTPIYILRIQATNNEDT---SSVTVTVNILEENDEKPICTPNSYFLALPVDLKV 581 +D ET Y L + AT+ S++ V + + + ND P+ + Y+ PV ++ Sbjct: 1104 DILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY---PVVMEN 1160 Query: 582 G-TNIQNFKLTCTDLDSSP-RSFRYSIGPGNVNNHFTFSPNAG 622 ++ ++ D DSS Y I GN N F + G Sbjct: 1161 SPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTG 1203 Score = 92.8 bits (229), Expect = 1e-18 Identities = 120/483 (24%), Positives = 205/483 (42%), Gaps = 37/483 (7%) Query: 125 DVNE-PPQFQGNLAEGLHLYIVER-ANPGFIYQVEAFDPEDTSRNIPLSYFLI-SPPKSF 181 DVN+ PP F ++ + + E A + +V+A DP D N + Y L S F Sbjct: 3123 DVNDNPPVFS---SDHYNTCVYENTATKALLTRVQAVDP-DIGINRKVVYSLADSAGGVF 3178 Query: 182 RM-SANGTLFSTTELDFEAGHRSFHLIVEVRDSG---GLKASTELQVNIVNLNDEVPRFT 237 + S++G + LD E S+++ V D L + T + + ++++ND P F Sbjct: 3179 SIDSSSGIIILEQPLDREQ-QSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFE 3237 Query: 238 SPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FMINQLTGTIQVA 295 + TV E+ SPGT V + A D G + + Y I + ++ F IN TG I V+ Sbjct: 3238 RRDYLVTVPEDTSPGTQVLAVFATSKDI-GTNAEITYLIRSGNEQGKFKINPKTGGISVS 3296 Query: 296 QRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVP 355 + +D + + L V KD + + DVNDNP + +S ++ Sbjct: 3297 EVLDYELCK-----RFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVIS 3351 Query: 356 ERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDY 415 E G ++ L +D PN + +F++ +G + F DP G + + LD Sbjct: 3352 EDALVGDSVILL---IAEDVDSQPNGQIHFSIVNG-DRDNEFTVDPV-LGLVKVKKKLDR 3406 Query: 416 ENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRP 475 E S Y++++Q D P + V I S N+ +F +Y + E +P Sbjct: 3407 ERVSG------YSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKP 3460 Query: 476 ARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIY 535 T + Q+ TD+D + +S S + + F ++P G L+ + Y Sbjct: 3461 VGTSILQLVVTDRDSFHNGPPFSFSILSGNEE--EEFVLDPH-GILRSAVVFQHTESLEY 3517 Query: 536 ILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTC 592 +L +QA ++ + S + V ++EE+ KP P F+ D G I T Sbjct: 3518 VLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATD 3577 Query: 593 TDL 595 D+ Sbjct: 3578 QDM 3580 Score = 85.9 bits (211), Expect = 2e-16 Identities = 133/595 (22%), Positives = 241/595 (40%), Gaps = 92/595 (15%) Query: 62 IVNSNPLTEAFRVN---WLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQV 118 IV +PL + F WL+ E +Q+D+E+ P ++L + KD+ Sbjct: 303 IVAGDPLDQFFLAKEGKWLN----EYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSA 358 Query: 119 LTV----QVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLS--- 171 L T P +F+ + + + I E + PG + + PE LS Sbjct: 359 LKAVYIGNPTRDTVPIRFEKEVYD---VSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGE 415 Query: 172 ---YFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVN 228 YF I+P ++A + + + G LKA ++ ++I + Sbjct: 416 DAVYFKINPRSGLIVTAR---------PLNTVKKEVYKLEVTNKEGDLKA--QVTISIED 464 Query: 229 LNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY-FMINQ 287 ND P F P V E + GT V ++A D D+G ++ YSI +++ F+INQ Sbjct: 465 ANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASD-KDKGENGYITYSIASLNLLPFVINQ 523 Query: 288 LTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGG---QENRIQITFIVEDVNDNPAT 344 TG I + +D +P I +V+ +G E+ + +T + +VNDN Sbjct: 524 FTGVISTTEELD-----FESSPEI-YRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPL 577 Query: 345 CQKFTFSIMVP-------ERTAKGTLLLD--------------LNKFCFDDDSEAPNNRF 383 +K ++ TA + +D L F + DS + Sbjct: 578 FEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKK 637 Query: 384 NFTMPSGVGSGS----------RFLQDPAGSGKIVLIGDLDYEN----PSNLAAGNKYTV 429 + T SG+ +G+ L DP VL G + ++ + +A + Sbjct: 638 SLT-NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKL 696 Query: 430 IIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDR--PSYVFDVSERRPARTRVGQVRATD 487 +I+ + ++ + + + + FD+ PS V V E P + +++A D Sbjct: 697 LIKAKANGKLNLEDGFLDFYSINRQGPY---FDKSFPSDV-AVKEDLPVGANILKIKAYD 752 Query: 488 KDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRI---QATN 543 D +L++IS G + F I+ +TG+L+++ +D E T +Y+L I N Sbjct: 753 ADSGFNGKVLFTISDGNTD----SCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGN 808 Query: 544 NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSS 598 + +S +T+N+ + ND P+ +SY + + +GT I + DL S+ Sbjct: 809 PQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863 Score = 85.5 bits (210), Expect = 2e-16 Identities = 114/474 (24%), Positives = 190/474 (40%), Gaps = 54/474 (11%) Query: 167 NIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRS-FHLIVEV-RDSGGLK-ASTELQ 223 N PL Y +++P F++ + + TT + F+ + + L+VE R+ L+ A ++ Sbjct: 2012 NEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVR 2071 Query: 224 VNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYF 283 VNI ++ND P F V + PGT++ +TA D D+G + Y + +F Sbjct: 2072 VNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAID-KDKGPNGEVTYVLQDDYGHF 2130 Query: 284 MINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPA 343 IN +G + + + + D + TI L KD +++ + VN Sbjct: 2131 EINPNSGNVILKEAFNSDLSNIEYGVTI----LAKDGGKPSLSTSVELPITI--VNKAMP 2184 Query: 344 TCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVG------SGSRF 397 K ++ V E T +L +N T P G G G F Sbjct: 2185 VFDKPFYTASVNEDIRMNTPILSINA----------------TSPEGQGIIYIIIDGDPF 2228 Query: 398 LQ--DPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPEN 455 Q +G + ++ LDYE S Y + I+ D A + V V +L + N Sbjct: 2229 KQFNIDFDTGVLKVVSPLDYEVTS------AYKLTIRASD-ALTGARAEVTVDLLVNDVN 2281 Query: 456 EFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWI 514 + P IFD+P+Y +SE T V QV + D D + ++ Y I + + F I Sbjct: 2282 DNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD--TYNSTDYFHI 2339 Query: 515 NPKTGELQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTP--- 568 + +G + +D E L++++ ++ +S V V + I + ND P+ Sbjct: 2340 DSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIY 2399 Query: 569 NSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAG 622 SY L T +Q +D D YSI GN F +G Sbjct: 2400 ESYVSELAPRGHFVTCVQASDADSSDFD----RLEYSILSGNDRTSFLMDSKSG 2449 Score = 82.8 bits (203), Expect = 1e-15 Identities = 141/613 (23%), Positives = 243/613 (39%), Gaps = 97/613 (15%) Query: 83 EVVTTGMEQLDFETGPNIFDLQIYVK--DEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEG 139 +V+TT E+LD E P D+ I+V+ D G T + V V D N+ PQF Sbjct: 2551 QVITT--ERLDREN-PLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMT----- 2602 Query: 140 LHLYIVERANPG---FIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELD 196 + RA+ G + QV+A DP+D + N ++Y L S A+ ++ E+D Sbjct: 2603 VEYRASVRADVGRGHLVTQVQAIDPDDGA-NSRITYSLYS-------EASVSVADLLEID 2654 Query: 197 FEAG------------HRSFHLIVEVRDSGGLKASTELQVNIVNLNDE--VPRFTSPTRV 242 + G + V+ D G + + V I L E +P FT Sbjct: 2655 PDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYS 2714 Query: 243 YTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSK--------YFMINQLTGTIQV 294 +T+ E+ + G+ V + PS ++ T + F+I Q TGTI++ Sbjct: 2715 FTIAEDTAIGSTVDTLRI-------LPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKL 2767 Query: 295 AQRIDRD---AGELRQNPTISLEVLVKDRPYGGQENRIQITFIVE------DVNDNPATC 345 +R+DR+ A + TI L+ ++ I F V+ D+NDN Sbjct: 2768 DKRLDRETSPAFHFKVAATIPLD-------------KVDIVFTVDVDIKVLDLNDNKPVF 2814 Query: 346 QKFTFSIMVPERTAKGTLLLDLNKFCFD--DDSEAPNNRFNFTMPSGVGSGSRFLQDPAG 403 + ++ ++ E GT L + D + + + + + P V + Sbjct: 2815 ETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNI---DSN 2871 Query: 404 SGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY-YKNNVYVYILTSPENEFPLIFD 462 +G I + DLD+E +T + D+ + + V + + N+ +F Sbjct: 2872 TGWISTLKDLDHETDPT------FTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFA 2925 Query: 463 RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522 + Y +V E P V + D+D + S G + + + ++ Sbjct: 2926 QEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVY 2985 Query: 523 LVTKVDCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVG 582 + +D E IY L I AT+ + V V++ + ND P+C +Y LP D + Sbjct: 2986 VKRPLDREEQDIYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPED--IP 3043 Query: 583 TNIQNFKLTCTDLDSSPRSF-RYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFD 641 +N K++ D D + RYS+ G+ N+ F P +G T LL + Sbjct: 3044 SNKIILKVSAKDADIGSNGYIRYSL-YGSGNSEFFLDPESGELKTLALLDR--------E 3094 Query: 642 KIWDYKLLVYVTD 654 +I Y L+ TD Sbjct: 3095 RIPVYSLMAKATD 3107 Score = 77.8 bits (190), Expect = 4e-14 Identities = 136/580 (23%), Positives = 227/580 (39%), Gaps = 67/580 (11%) Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90 V EN GTSV S ++L V + F +N SG V T + Sbjct: 1680 VNENVDIGTSVILISAISQSTLI-------YEVKDGDINGIFTINPYSG-----VITTQK 1727 Query: 91 QLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPP------QFQGNLAEGLHLYI 144 LD+E + + L I + G+ + +Q+ D N+ Q+ G+L+E + Sbjct: 1728 ALDYERTSS-YQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINS 1786 Query: 145 VERANPGFIYQVEAFDPEDTSRNIPLSYFLI-SPPKSFRM--SANGTLFSTTELDFEAGH 201 + R+ + A D D++RN L Y ++ S K F S+ G + + LD E Sbjct: 1787 IVRSLDNSPLVIRATDA-DSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHET-I 1844 Query: 202 RSFHLIVEVRDSGG--LKASTELQVNI--VNLNDEVPRFTSPTRVYTVLEELSPGTIVAN 257 FH V VRDSG L A + ++VNI ++ND P FT +L G V Sbjct: 1845 AHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLK 1904 Query: 258 ITAEDPDDEGFPSHLLYSITTVS-KYFMINQLTGTIQVAQRIDRDAGELRQNPTISLE-- 314 ++A DPD E P L YS+ S +F+I+ +G + + +N +S + Sbjct: 1905 VSATDPDSE-VPPELTYSLMEGSLDHFLIDSNSGVLTI------------KNNNLSKDHY 1951 Query: 315 VLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDD 374 +L+ G + +T +V++ D+ + +S + E T + +N Sbjct: 1952 MLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVN------ 2005 Query: 375 DSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQ 434 A NR N + + + + + SG I G P + Y ++++ Sbjct: 2006 ---AVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTG-----VPFDREEQELYELVVEAS 2057 Query: 435 DVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL-PQS 493 V V + N+ +F Y V T + QV A DKD P Sbjct: 2058 RELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNG 2117 Query: 494 SLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPI-YILRIQATNNEDTS-SVT 551 + Y + F INP +G + L + + + I Y + I A + S S + Sbjct: 2118 EVTYVLQDDYGH------FEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTS 2171 Query: 552 VTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLT 591 V + I N P+ Y ++ D+++ T I + T Sbjct: 2172 VELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211 Score = 52.4 bits (124), Expect = 2e-06 Identities = 131/598 (21%), Positives = 228/598 (38%), Gaps = 75/598 (12%) Query: 105 IYVKDEVGVTDLQVLT---VQVTDVNE------PPQFQGNLAEGLHLYIVERANPGFIYQ 155 + VK V DL+ T +QV D+N+ P + +AE L + Q Sbjct: 127 LIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS-------VAQ 179 Query: 156 VEAFDPEDTSRNIPLSYFLISPPKSFRMS-ANGTLFSTTELDFEAGHRSFHLIVEVRDSG 214 V A D D N Y+ + F + +G + + L+++ +R + L + D G Sbjct: 180 VTATDA-DIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNR-YDLEILAVDRG 237 Query: 215 -------GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEG 267 G+ ++ +L V+I +N+ P T V LE+ +V +D + Sbjct: 238 MKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGE 297 Query: 268 FPSHLLYSITTVSKYFMINQLTGT----IQVAQRIDRDAGELRQNPTISLEVLVKDRPYG 323 S + + + ++F+ + I+ ++ID ++ N T+ KD+ Sbjct: 298 IESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ----AKDKGSP 353 Query: 324 GQENRIQITFIVEDVNDN-PATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNR 382 + + ++ +I D P +K + + + E + G ++ + D E Sbjct: 354 QKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVE----- 408 Query: 383 FNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYK 442 G + + + SG IV P N Y + +V Sbjct: 409 ----YKLSPGEDAVYFKINPRSGLIVTA------RPLNTVKKEVYKL-----EVTNKEGD 453 Query: 443 NNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSIST 501 V I N+ F +P Y V+E P T V V A+DKD ++ + YSI Sbjct: 454 LKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI-- 511 Query: 502 GGASLQYPNVFWINPKTGELQLVTKVDCETTP-IYILRIQATN----NEDTSSVTVTVNI 556 ASL F IN TG + ++D E++P IY ++A++ S V VT+ I Sbjct: 512 --ASLNLLP-FVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRI 568 Query: 557 LEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFT 616 ND P+ + + D VG +I ++ D+D +Y I GN F Sbjct: 569 GNVNDNSPLFEKVACQGVISYDFPVGGHIT--AVSAIDIDEL-ELVKYKIISGNELGFFY 625 Query: 617 FSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVT 674 +P++G + LT+ G F L + TD ++D V G V+ Sbjct: 626 LNPDSGVLQLKKSLTNSGIKNGNF------ALRITATDGENLADPMSINISVLHGKVS 677 >gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] Length = 4349 Score = 119 bits (298), Expect = 1e-26 Identities = 126/459 (27%), Positives = 199/459 (43%), Gaps = 42/459 (9%) Query: 187 GTLFSTTELDFEAGHRSFHLI-VEVRDSGGLKASTE--LQVNIVNLNDEVPRFTSPTRVY 243 G L LD+EA +F+++ V V D G + S+ L VN+ + ND PRF Sbjct: 770 GLLTVAAPLDYEA--TNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQL 827 Query: 244 TVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAG 303 T+ E+ GT +A +T +D D E + Y++ + ++ F ++ LTG + V +DR++ Sbjct: 828 TISEDTEVGTTIAELTTKDADSED-NGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRES- 885 Query: 304 ELRQNPTISLEVLVKDRPYGGQE--NRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361 P L+V +D+P G + + + +EDVNDN C + VPE G Sbjct: 886 ----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPG 941 Query: 362 TLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNL 421 T+L L+ D P + + G R +G ++L +LD+E + Sbjct: 942 TVLTFLDA---SDPDLGPAGEVRYVLMDGAHGTFRV---DLMTGALILERELDFERRAG- 994 Query: 422 AAGNKYTVIIQVQDVAPPYYKN---NVYVYILTSPENEFPLIFDRPSYVFDVSERRPART 478 Y + + D P + +V V +L EN P F + V E P+ T Sbjct: 995 -----YNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGT 1049 Query: 479 RVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILR 538 +V V A D D L G L F IN TG +Q + +D E Y L Sbjct: 1050 QVIVVAAQDDDSGLDGELQYFLRAGTGLA---AFSINQDTGMIQTLAPLDREFASYYWLT 1106 Query: 539 IQATNNEDT--SSVT-VTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDL 595 + A + SSVT V + + + ND P + ++ ++ D VGT++ +L D Sbjct: 1107 VLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSV--LQLDAWDP 1164 Query: 596 DSSPR-SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSR 633 DSS + ++I GN F P VT LL T++ Sbjct: 1165 DSSSKGKLTFNITSGNYMGFFMIHP-----VTGLLSTAQ 1198 Score = 108 bits (269), Expect = 3e-23 Identities = 134/513 (26%), Positives = 219/513 (42%), Gaps = 48/513 (9%) Query: 123 VTDVNE-PPQFQGNLAEGLHLYIVERANPG-FIYQVEAFDPEDTSRNIPLSYFLISP-PK 179 V DVN+ PQ L G + E PG FI +V A D DT N ++Y L P Sbjct: 3001 VLDVNDNSPQCSQLLYTGK---VHEDVFPGHFILKVSATDL-DTDTNAQITYSLHGPGAH 3056 Query: 180 SFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTS 238 F++ + G L + T LD E F+L+ + D GG ++ +++ ++ND PRF Sbjct: 3057 EFKLDPHTGELTTLTALDRERKD-VFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFP 3115 Query: 239 PTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI-TTVSKYFMINQLTGTIQVAQR 297 V + + T VA + A DP D+G + ++YS+ + +F I+ TG I++ + Sbjct: 3116 SHCAVAVFDNTTVKTPVAVVFARDP-DQGANAQVVYSLPDSAEGHFSIDATTGVIRLEK- 3173 Query: 298 IDRDAGELRQNPTISLEVLVKDRPYGGQ---ENRIQITFIVEDVNDNPATCQKFTFSIMV 354 L+ P LE+ V+ G +T V + D S+ V Sbjct: 3174 ------PLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQV 3227 Query: 355 PERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLD 414 PE GT +L L + + + + SG G RF D A +G + + LD Sbjct: 3228 PEDAPPGTEVLQLATL-----TRPGAEKTGYRVVSGNEQG-RFRLD-ARTGILYVNASLD 3280 Query: 415 YENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERR 474 +E KY + I+ + + V + + NE F + Y V E Sbjct: 3281 FE------TSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENA 3334 Query: 475 PARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTP 533 + V ATD+D P S + YS+ GG L + F I+PK GELQ+ +D E Sbjct: 3335 LVGDVILTVSATDEDGPLNSDITYSL-IGGNQLGH---FTIHPKKGELQVAKALDREQAS 3390 Query: 534 IYILRIQATN------NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQN 587 Y L+++AT+ +EDT + + + + ND P +Y + + +G+ + Sbjct: 3391 SYSLKLRATDSGQPPLHEDTD---IAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQ 3447 Query: 588 FKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPN 620 L+ D + + + I GN + F +P+ Sbjct: 3448 LILSDPDSPENGPPYSFRITKGNNGSAFRVTPD 3480 Score = 107 bits (268), Expect = 4e-23 Identities = 134/519 (25%), Positives = 218/519 (42%), Gaps = 38/519 (7%) Query: 92 LDFE-TGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVERAN 149 LD+E T I ++ +Y + ++LTV V D N+ P+F G L I E Sbjct: 778 LDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPG---GYQLTISEDTE 834 Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSA-NGTLFSTTELDFEAGHRSFHLIV 208 G D+ N + Y L+SP + F + G L T LD E+ R + L V Sbjct: 835 VGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEPR-YILKV 893 Query: 209 EVRDSGG----LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPD 264 E RD L + T+L + + ++ND P+ + V E+L PGT++ + A DPD Sbjct: 894 EARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPD 953 Query: 265 DEGFPSHLLYSITTVSK-YFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYG 323 G + Y + + F ++ +TG + + + +D E R +SL RP Sbjct: 954 -LGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDF---ERRAGYNLSLWASDGGRPLA 1009 Query: 324 GQENRIQITFIVEDVNDN--PATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNN 381 + + IV DVN+N P F V E + GT ++ + DD + Sbjct: 1010 -RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVV---AAQDDDSGLDG 1065 Query: 382 RFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYY 441 + + +G G + + +G I + LD E S Y + + D Sbjct: 1066 ELQYFLRAGTGLAAFSINQD--TGMIQTLAPLDREFASY------YWLTVLAVDRGSVPL 1117 Query: 442 KNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLP-QSSLLYSIS 500 + VYI + N+ P + + + E P T V Q+ A D D + L ++I+ Sbjct: 1118 SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNIT 1177 Query: 501 TGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNED---TSSVTVTVNIL 557 +G Y F I+P TG L ++D E +IL + +N + S+ V V IL Sbjct: 1178 SGN----YMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGIL 1233 Query: 558 EENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLD 596 + ND PI + + + LP L + ++L +DLD Sbjct: 1234 DVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLD 1272 Score = 105 bits (262), Expect = 2e-22 Identities = 149/616 (24%), Positives = 249/616 (40%), Gaps = 61/616 (9%) Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90 V E+ PPGT V F L P G + V + FRV+ ++G Sbjct: 934 VPEDLPPGT-VLTFLDASDPDLGPA--GEVRYVLMDGAHGTFRVDLMTGALILE-----R 985 Query: 91 QLDFETGPNIFDLQIYVKD---EVGVTDLQVLTVQVTDVNE---PPQFQGNLAEGLHLYI 144 +LDFE ++L ++ D + L + V V DVNE PP F + +G + Sbjct: 986 ELDFERRAG-YNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQG---QV 1041 Query: 145 VERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEAGH 201 E + G V A +D+ + L YFL + S N G + + LD E Sbjct: 1042 QENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFAS 1101 Query: 202 RSFHLIVEV-RDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITA 260 + ++ V R S L + TE+ + + + ND P+ + ++ E+ GT V + A Sbjct: 1102 YYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDA 1161 Query: 261 EDPDDEGFPSHLLYSITTVSK--YFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVK 318 DPD L ++IT+ + +FMI+ +TG + AQ++DR+ + LEV V Sbjct: 1162 WDPDSSS-KGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEH-----ILEVTVL 1215 Query: 319 DRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEA 378 D ++ ++ + DVNDNP F++ +PER + + + D E Sbjct: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSP-VSPGPVYRLVASDLDEG 1274 Query: 379 PNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAP 438 N R +++ S +G + + S AG + I+ D Sbjct: 1275 LNGRVTYSIED---SDEEAFSIDLVTGVV--------SSSSTFTAGEYNILTIKATDSGQ 1323 Query: 439 PYYKNNVYVYILTSP---ENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSL 495 P +V ++I P + PL FD Y F V E P VG + + Sbjct: 1324 PPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGR---PGLF 1380 Query: 496 LYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVTVTVN 555 ++IS G + F I TG + + +D Y L ++ T+ T + V + Sbjct: 1381 WFNISGGDKDMD----FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIF 1436 Query: 556 ILEE-NDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSI----GPGN 610 ++ N +P Y + +P D G ++ ++ D D +S Y+I PG+ Sbjct: 1437 MIANINHHRPQFLETRYEVRVPQDTVPG--VELLRVQAIDQDKG-KSLIYTIHGSQDPGS 1493 Query: 611 VNNHFTFSPNAGSNVT 626 + F P++G VT Sbjct: 1494 A-SLFQLDPSSGVLVT 1508 Score = 105 bits (262), Expect = 2e-22 Identities = 149/611 (24%), Positives = 245/611 (40%), Gaps = 124/611 (20%) Query: 121 VQVTDVNE-PPQFQG-----NLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFL 174 V V DVN+ PP F +++EGL + Q+ A D +D+ RN +SY + Sbjct: 2260 VLVEDVNDNPPTFSQLVYTTSISEGLPAQTP-------VIQLLASD-QDSGRNRDVSYQI 2311 Query: 175 ISP----PKSFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIV 227 + K F+++ + G + + ELD+EA + FH+ V D G L T + VN+ Sbjct: 2312 VEDGSDVSKFFQINGSTGEMSTVQELDYEA-QQHFHVKVRAMDKGDPPLTGETLVVVNVS 2370 Query: 228 NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITT--VSKYFMI 285 ++ND P F P V E + G +V + A DPD S L Y I + ++F I Sbjct: 2371 DINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRD-TSRLEYLILSGNQDRHFFI 2429 Query: 286 NQLTGTIQVAQ------------RIDRDAG-----------------------------E 304 N +G I + R+ G E Sbjct: 2430 NSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQHLYEAE 2489 Query: 305 LRQNPTIS---LEVLVKDR---PYGGQENRIQITFIVEDVNDNP----ATCQKF------ 348 L +N + +++L D+ PYG + I E + NP AT QK Sbjct: 2490 LAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLDRENST 2549 Query: 349 --TFSIMVPERTAKGTLLLDLNKFCFDDDSEAP----NNRFNFTMPSGVGSGSRFLQDPA 402 +I V R G + K D+++ P + + ++ S V S +Q A Sbjct: 2550 ERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLA 2609 Query: 403 GSGKIVLIGDLDYE-NPSNLAAG----NKYTVIIQVQDV------------------APP 439 D+ Y NP +L N T +++V+D PP Sbjct: 2610 YDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPP 2669 Query: 440 YYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSI 499 ++ + V V + P+ F P Y F E P + +G V+A Q ++YS+ Sbjct: 2670 HWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAV---AAQDPVIYSL 2726 Query: 500 STGGA-SLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA---TNNEDTSSVTVTVN 555 G VF ++P TG +++ +D E+T +Y + + A N + S V+V + Sbjct: 2727 VRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQ 2786 Query: 556 ILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDS---SPRSFRYSIGPG-NV 611 + + ND +P+ + Y L ++ VGT++ ++T D D+ S+R S PG NV Sbjct: 2787 VGDVNDNRPVFEADPYKAVLTENMPVGTSV--IQVTAIDKDTGRDGQVSYRLSADPGSNV 2844 Query: 612 NNHFTFSPNAG 622 + F +G Sbjct: 2845 HELFAIDSESG 2855 Score = 102 bits (254), Expect = 2e-21 Identities = 152/656 (23%), Positives = 264/656 (40%), Gaps = 83/656 (12%) Query: 34 NSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLD 93 ++PP S F+V+L LSPV PG + ++ L E L+G VT +E D Sbjct: 1237 DNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEG-----LNGR----VTYSIEDSD 1287 Query: 94 FET-GPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGF 152 E ++ + + +LT++ TD +PP + + LH+ + P Sbjct: 1288 EEAFSIDLVTGVVSSSSTFTAGEYNILTIKATDSGQPPL---SASVRLHIEWIPWPRPSS 1344 Query: 153 I----------YQVEAFDPEDTSRNI-------PLSYFLIS---PPKSFRMS-ANGTLFS 191 I + V DP + + L +F IS F + G++ Sbjct: 1345 IPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVI 1404 Query: 192 TTELDFEAGHRSFHLIVEVRDSGGLKASTELQV-NIVNLNDEVPRFTSPTRVYTVLEELS 250 LD +++L VEV D G +T++ + I N+N P+F V ++ Sbjct: 1405 ARPLDTRR-RSNYNLTVEVTD-GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTV 1462 Query: 251 PGTIVANITAEDPDDEGFPSHLLYSI-----TTVSKYFMINQLTGTIQVAQRIDRDAGEL 305 PG + + A D D L+Y+I + F ++ +G + ++D +G Sbjct: 1463 PGVELLRVQAIDQDKG---KSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPS 1519 Query: 306 RQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLL 365 + +L V+V+D+ + N + +T VED N +P + + VP+ A GT LL Sbjct: 1520 QH----TLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELL 1575 Query: 366 DLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGN 425 + D N ++++ G G F A G I L LD N + Sbjct: 1576 QVRAM---DADRGVNAEVHYSLLKGNSEG--FFNINALLGIITLAQKLDQANHA------ 1624 Query: 426 KYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRA 485 +T+ ++ +D P + + V I P + IF + Y ++ E P + + V A Sbjct: 1625 PHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA 1684 Query: 486 TDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNE 545 + S + Y + G VF +N +G + K+D E Y L+I+ +N Sbjct: 1685 ----MSPSEVTYELREGNKD----GVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMA 1736 Query: 546 DT-SSVTVTVNILEENDEKPICTPNSYF----LALPV-DLKVGTNIQNFKLTCTDLDSSP 599 + V V V+I++END P+ +++ A P+ + + N F + +D D Sbjct: 1737 GAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEA 1796 Query: 600 RSFR-YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTD 654 S Y I F P+ G+ L + S DY + + ++ VYV D Sbjct: 1797 NSLLVYKILEPEALKFFKIDPSMGT----LTIVSEMDY----ESMPSFQFCVYVHD 1844 Score = 101 bits (251), Expect = 3e-21 Identities = 122/511 (23%), Positives = 215/511 (42%), Gaps = 56/511 (10%) Query: 167 NIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFH-LIVEVRDSGGLKASTE--LQ 223 N LSYFL++ F M + + T + F+ + H L VEVRD+ + + ++ Sbjct: 1998 NDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVR 2057 Query: 224 VNIVNLNDEVPRFTSPTRVYTVLEE-LSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY 282 V+I ++ND P+F YT++++ PG ++ ++A D +D G + Y Y Sbjct: 2058 VSIEDVNDNPPKFKH-LPYYTIIQDGTEPGDVLFQVSATD-EDLGTNGAVTYEFAEDYTY 2115 Query: 283 FMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNP 342 F I+ G I + + D A L+V+ +D ++ ++ V + NP Sbjct: 2116 FRIDPYLGDISLKKPFDYQALN-----KYHLKVIARDGGTPSLQSEEEVLVTVRN-KSNP 2169 Query: 343 ATCQKFTFSIMVPERTAKGTLLLDLN-------KFCFDDDSEAPNNRFNFTMPSGVGSGS 395 + + + VPE T +L + ++ E P F +GV Sbjct: 2170 LFQSPY-YKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGV---- 2224 Query: 396 RFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPEN 455 + + G LDYE+ + K+ ++ D A + + V +L N Sbjct: 2225 -----------LTVTGPLDYESKT------KHVFTVRATDTALGSF-SEATVEVLVEDVN 2266 Query: 456 EFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQS-SLLYSISTGGASLQYPNVFWI 514 + P F + Y +SE PA+T V Q+ A+D+D ++ + Y I G+ + F I Sbjct: 2267 DNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVS--KFFQI 2324 Query: 515 NPKTGELQLVTKVDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSY 571 N TGE+ V ++D E + ++++A + D T V VN+ + ND P Y Sbjct: 2325 NGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQY 2384 Query: 572 FLALPVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAG----SNVT 626 + G + K+ D DS S Y I GN + HF + ++G N+ Sbjct: 2385 EANVSELATCGHLV--LKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLC 2442 Query: 627 RLLLTSRFDY-AGGFDKIWDYKLLVYVTDDN 656 + L S ++ G D ++ + VY+ N Sbjct: 2443 KKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473 Score = 92.0 bits (227), Expect = 2e-18 Identities = 142/614 (23%), Positives = 257/614 (41%), Gaps = 55/614 (8%) Query: 26 PATGNVAENSPPGTSVHKFSV--KLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFE 83 P + EN P GTSV + + K + V SN + E F ++ SG Sbjct: 2801 PYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSN-VHELFAIDSESGWI-- 2857 Query: 84 VVTTGMEQLDFETGPNI-FDLQIYVKDE-VGVTDLQVLTVQVTDVNE-PPQFQGNLAEGL 140 T +++LD ET F + Y + + ++ ++ V +TD N+ P+F G Sbjct: 2858 ---TTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGS 2914 Query: 141 HLYIVERANPG-FIYQVEAFDPEDTSRNIPLSYFLIS--PPKSFRMSANGT---LFSTTE 194 +VE + PG + ++ D + + +N ++ ++ P F +S G + S Sbjct: 2915 ---VVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKT 2971 Query: 195 LDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTI 254 LD E H + +L+ G +AS +++ ++++ND P+ + V E++ PG Sbjct: 2972 LDRE--HTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHF 3029 Query: 255 VANITAEDPDDEGFPSHLLYSITTVSKY-FMINQLTGTIQVAQRIDRDAGELRQNPTISL 313 + ++A D D + + + YS+ + F ++ TG + +DR+ ++ Sbjct: 3030 ILKVSATDLDTDT-NAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDV-------F 3081 Query: 314 EVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373 ++ K GG+ + IT VEDVNDN ++ V + T T + + F D Sbjct: 3082 NLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVV--FARD 3139 Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433 D A N + +++P S A +G I L E P + + ++ Sbjct: 3140 PDQGA-NAQVVYSLPD---SAEGHFSIDATTGVIRL------EKPLQVRPQAPLELTVRA 3189 Query: 434 QDVAPPYYKNNV-YVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQ 492 D+ P + + V + ++ +F + V E P T V Q+ + + Sbjct: 3190 SDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE 3249 Query: 493 SSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSS--- 549 + Y + +G + F ++ +TG L + +D ET+P Y L I+ + +S Sbjct: 3250 KTG-YRVVSGNEQGR----FRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304 Query: 550 VTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGP 608 TV VNI + N+ +P + Y + + VG I ++ TD D S YS+ Sbjct: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVI--LTVSATDEDGPLNSDITYSLIG 3362 Query: 609 GNVNNHFTFSPNAG 622 GN HFT P G Sbjct: 3363 GNQLGHFTIHPKKG 3376 Score = 86.3 bits (212), Expect = 1e-16 Identities = 158/713 (22%), Positives = 276/713 (38%), Gaps = 114/713 (15%) Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90 ++E SPPG+ V + ++P P ++ + F++N +G + TT + Sbjct: 371 LSEFSPPGSRV------VMVRVTPAFPNLQYVLKPSSENVGFKLNARTGL---ITTTKL- 420 Query: 91 QLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDV----NEPPQFQGNLAEGLHLYIVE 146 +DF + Q++++ G Q TV V D+ N P F + +G + E Sbjct: 421 -MDFHDRAHY---QLHIRTSPG----QASTVVVIDIVDCNNHAPLFNRSSYDGT---LDE 469 Query: 147 RANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEAGHRS 203 PG D N ++Y I+ PK+ S + G + ++ +D+E R Sbjct: 470 NIPPGTSVLAVTATDRDHGENGYVTYS-IAGPKALPFSIDPYLGIISTSKPMDYELMKRI 528 Query: 204 FHLIVEVRDSGG---LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITA 260 + V D G + + + + NLND P F ++ ++ G + ++A Sbjct: 529 YTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSA 588 Query: 261 EDPDDEGFPSHLLYSITTVS--KYFMINQLTGTIQVAQR-IDRDAGELRQNPTISLEVLV 317 D D+ +L Y I + + +YF +N +G I + + I+ AG Q + SL++ Sbjct: 589 IDVDE---LQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAG---QPTSYSLKITA 642 Query: 318 KDRPYGGQENRIQITFIVEDVNDNPATCQK------FTFSIM-----------VPERTAK 360 D + IT + + + P TC K FT +I+ E T+ Sbjct: 643 SDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSL 702 Query: 361 GTLLLDLNKFCFDDD---------------------SEAPNNRFNFTMPSGVGSGSR--F 397 T ++ F+D + P+ FN + + G+ Sbjct: 703 STYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGC 762 Query: 398 LQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEF 457 +G + + LDYE A N Y + + V D+ P + + + N+ Sbjct: 763 FDIELETGLLTVAAPLDYE------ATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDN 816 Query: 458 PLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSS-LLYSISTGGASLQYPNVFWINP 516 F Y +SE T + ++ D D + + Y++ L F ++P Sbjct: 817 APRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTL------LSPTEKFSLHP 870 Query: 517 KTGELQLVTKVDCETTPIYILRIQA----TNNEDTSSVTVTVNILEE-NDEKPICTPNSY 571 TGEL + +D E+ P YIL+++A + SVT + LE+ ND P C Sbjct: 871 LTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHN 930 Query: 572 FLALPVDLKVGTNIQNFKLTCTDLDSSPR-SFRYSIGPGNVNNHFTFSPNAGSNVTRLLL 630 L +P DL GT + F L +D D P RY + G H TF + + L+L Sbjct: 931 RLKVPEDLPPGT-VLTF-LDASDPDLGPAGEVRYVLMDG---AHGTFRVDLMTGA--LIL 983 Query: 631 TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPHP 683 D F++ Y L ++ +D R+ L + L + HP Sbjct: 984 ERELD----FERRAGYNLSLWASDGGRPLARR---TLCHVEVIVLDVNENLHP 1029 Score = 79.0 bits (193), Expect = 2e-14 Identities = 124/581 (21%), Positives = 243/581 (41%), Gaps = 60/581 (10%) Query: 74 VNWLSGTYFEVVTTG----MEQLDFETGPN-IFDLQIYVKDEVGVTDLQVLTVQVTDVNE 128 +N L+ F + G +++LD E + +++ +D G + + +TD N+ Sbjct: 2521 INKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDEND 2580 Query: 129 -PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFR--MSA 185 PPQF+ + V + +P + QV A+D D +N ++Y ++P + + Sbjct: 2581 NPPQFKASEYTVSIQSNVSKDSP--VIQVLAYDA-DEGQNADVTYS-VNPEDLVKDVIEI 2636 Query: 186 NGTLFSTTELDFEAG--HRSFHLIVEVRDSGG--LKASTELQVNIVNLNDEVPRFTSPTR 241 N D G +++ ++ +D G + +++ +V +P+F+ P Sbjct: 2637 NPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLY 2696 Query: 242 VYTVLEELSPGT---IVANITAEDPDDEGFPSHLLYSI-------TTVSKYFMINQLTGT 291 ++ E+L G+ IV + A+DP ++YS+ + F ++ TG Sbjct: 2697 TFSAPEDLPEGSEIGIVKAVAAQDP--------VIYSLVRGTTPESNKDGVFSLDPDTGV 2748 Query: 292 IQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFS 351 I+V + +D ++ +L Q ++V+ + + + V DVNDN + + Sbjct: 2749 IKVRKPMDHESTKLYQ-----IDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYK 2803 Query: 352 IMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFL-QDPAGSGKIVLI 410 ++ E GT ++ + D + + ++ + + GS L + SG I + Sbjct: 2804 AVLTENMPVGTSVIQVTAI---DKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTL 2860 Query: 411 GDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDV 470 +LD E + ++ + V + + EN+ F Y V Sbjct: 2861 QELDCETCQTY-----HFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSV 2915 Query: 471 SERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTK--V 527 E V ++ D D+ Q+ + T G L F I+ E ++ ++ + Sbjct: 2916 VENSEPGELVATLKTLDADISEQNRQVTCYITEGDPL---GQFGISQVGDEWRISSRKTL 2972 Query: 528 DCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQN 587 D E T Y+LR+ A++ + +SVTV + +L+ ND P C+ Y + D+ G I Sbjct: 2973 DREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFI-- 3030 Query: 588 FKLTCTDLDSSPRS-FRYSI-GPGNVNNHFTFSPNAGSNVT 626 K++ TDLD+ + YS+ GPG + F P+ G T Sbjct: 3031 LKVSATDLDTDTNAQITYSLHGPG--AHEFKLDPHTGELTT 3069 Score = 70.1 bits (170), Expect = 9e-12 Identities = 143/619 (23%), Positives = 256/619 (41%), Gaps = 72/619 (11%) Query: 29 GNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTG 88 G V ENSP GT V V S + + + AF +N +G + Sbjct: 1039 GQVQENSPSGTQV--IVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTG-----MIQT 1091 Query: 89 MEQLDFETGPNIFDLQIYV-KDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVE 146 + LD E + + V + V ++ + + ++VTD N+ PPQ + + I E Sbjct: 1092 LAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAV---FYPSIQE 1148 Query: 147 RANPG-FIYQVEAFDPEDTSR-----NIP----LSYFLISPPKSFRMSANGTLFSTTELD 196 A G + Q++A+DP+ +S+ NI + +F+I P G L + +LD Sbjct: 1149 DAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHP-------VTGLLSTAQQLD 1201 Query: 197 FEAGHRSFHLI-VEVRDSG--GLKASTELQVNIVNLNDEVPRFTSP---TRVYTVLEELS 250 E ++ H++ V V D+G LK+++ + V I+++ND P F+ R+ L +S Sbjct: 1202 RE--NKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVS 1259 Query: 251 PGTIVANITAEDPDDEGFPSHLLYSI-TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNP 309 PG + + ++ DEG + YSI + + F I+ +TG + + AGE Sbjct: 1260 PGPVYRLVASD--LDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTF--TAGEYN--- 1312 Query: 310 TISLEVLVKDRPYGGQENRIQITFIV-EDVNDNPATCQKFTFSIMVPERTAKGTLLLDLN 368 ++++ +P R+ I +I + P + +S V E +N Sbjct: 1313 ILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETD-------PVN 1365 Query: 369 KFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYT 428 E F F + G ++ GS IV+ LD SN Y Sbjct: 1366 HMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGS--IVIARPLDTRRRSN------YN 1417 Query: 429 VIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDK 488 + ++V D V+++++ + + P F Y V + + +V+A D+ Sbjct: 1418 LTVEVTD-GSRTIATQVHIFMIANINHHRPQ-FLETRYEVRVPQDTVPGVELLRVQAIDQ 1475 Query: 489 DLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPI-YILRIQATNNE-- 545 D SL+Y+I G ++F ++P +G L V K+D + P + L + + E Sbjct: 1476 D-KGKSLIYTIH-GSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIP 1533 Query: 546 -DTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS-FR 603 + V VT+++ + N P T Y ++P + GT + ++ D D + Sbjct: 1534 IKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTEL--LQVRAMDADRGVNAEVH 1591 Query: 604 YSIGPGNVNNHFTFSPNAG 622 YS+ GN F + G Sbjct: 1592 YSLLKGNSEGFFNINALLG 1610 Score = 68.9 bits (167), Expect = 2e-11 Identities = 91/410 (22%), Positives = 174/410 (42%), Gaps = 27/410 (6%) Query: 203 SFHLIVEVRDSG-GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAE 261 S+ LI++ + L+A T + V+I++ ND P F+ P+ T+ E++ + + +TA Sbjct: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTAT 173 Query: 262 DPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRP 321 D D G + Y+ T S+ F I+ +G + VA +++ + ++++ + K Sbjct: 174 DA-DLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISE 232 Query: 322 YGGQENRIQITFIVED-VNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPN 380 G + + VE + PA + T T+L+D N + +S Sbjct: 233 GNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVE-- 290 Query: 381 NRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY 440 + G + ++ A S + L+ D L + + + +Q + + PY Sbjct: 291 -----VVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYL---HGFNLSLQARSGSGPY 342 Query: 441 YKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSIS 500 + + + + L P L F++ Y +SE P +RV VR T P + S Sbjct: 343 FYSQIRGFHL-PPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA-FPNLQYVLKPS 400 Query: 501 TGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVTVTVNILEEN 560 + F +N +TG + +D Y L I+ + + +S V ++I++ N Sbjct: 401 SENVG------FKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQ--ASTVVVIDIVDCN 452 Query: 561 DEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSF-RYSI-GP 608 + P+ +SY L ++ GT++ +T TD D + YSI GP Sbjct: 453 NHAPLFNRSSYDGTLDENIPPGTSV--LAVTATDRDHGENGYVTYSIAGP 500 Score = 61.2 bits (147), Expect = 4e-09 Identities = 66/241 (27%), Positives = 103/241 (42%), Gaps = 20/241 (8%) Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90 V E++PPGT V ++L+ P V S FR++ +G + + Sbjct: 3227 VPEDAPPGTEV----LQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILYVNAS---- 3278 Query: 91 QLDFETGPNIF-DLQIYVKDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVERA 148 LDFET P F ++ K ++D+ + V +TDVNE PQF + ++E A Sbjct: 3279 -LDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFP---QDPYSTRVLENA 3334 Query: 149 NPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEAGHRSFH 205 G + + ED N ++Y LI + + + G L LD E S+ Sbjct: 3335 LVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQA-SSYS 3393 Query: 206 LIVEVRDSG--GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDP 263 L + DSG L T++ + + ++ND PRF TV E G+ V + DP Sbjct: 3394 LKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDP 3453 Query: 264 D 264 D Sbjct: 3454 D 3454 Score = 57.0 bits (136), Expect = 8e-08 Identities = 115/539 (21%), Positives = 206/539 (38%), Gaps = 88/539 (16%) Query: 80 TYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE------PPQFQ 133 +Y +++T ++LD E + + L+I + G ++ V + D N+ F Sbjct: 1707 SYSGLIST-QKKLDHEKISS-YQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFV 1764 Query: 134 GNLAEGLHLY--IVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPP--KSFRMSAN-GT 188 G ++E LY I+++ N F+ D E S L Y ++ P K F++ + GT Sbjct: 1765 GQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSL---LVYKILEPEALKFFKIDPSMGT 1821 Query: 189 LFSTTELDFEAGHRSFHLIVEVRDSGG----LKASTELQVNIVNLNDEVPRFTSPTRVYT 244 L +E+D+E+ SF V V D G ++ +++ ++ND PRF+ Sbjct: 1822 LTIVSEMDYES-MPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVA 1880 Query: 245 VLEELSPGTIVANITAEDPDDEGFPSHLLYSITT--VSKYFMINQLTGTIQVAQRIDRDA 302 ++ + PG + + A D D E + YSI T + I+ +TG+I V Sbjct: 1881 IVGPIHPGMELLMVRASDEDSE-----VNYSIKTGNADEAVTIHPVTGSISVL------- 1928 Query: 303 GELRQNPTI-----SLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPER 357 NP L + D Y ++ + + V D + + V E Sbjct: 1929 -----NPAFLGLSRKLTIRASDGLY---QDTALVKISLTQVLDKSLQFDQDVYWAAVKEN 1980 Query: 358 TAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIG---DLD 414 L+ L A N N T+ + +G+ +G + G D + Sbjct: 1981 LQDRKALVILG---------AQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDRE 2031 Query: 415 YENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERR 474 ++ LA ++V+D P V + N+ P F Y + + Sbjct: 2032 QQDTHELA--------VEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGT 2083 Query: 475 PARTRVGQVRATDKDLPQSSLLYSISTGGASLQYP---NVFWINPKTGELQLVTKVDCET 531 + QV ATD+DL + G + ++ F I+P G++ L D + Sbjct: 2084 EPGDVLFQVSATDEDLG--------TNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQA 2135 Query: 532 TPIYILRIQATNN-----EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI 585 Y L++ A + + V VTV N P+ Y + +P ++ + T I Sbjct: 2136 LNKYHLKVIARDGGTPSLQSEEEVLVTV----RNKSNPLFQSPYYKVRVPENITLYTPI 2190 Score = 40.0 bits (92), Expect = 0.010 Identities = 32/111 (28%), Positives = 55/111 (49%), Gaps = 10/111 (9%) Query: 420 NLAAGNKYTVIIQVQDVAPPYYK-NNVYVYILTSPENEFPLIFDRPSYVFDVSERRPART 478 N + YT+IIQ + V V+IL +N+ +F PSY +SE P ++ Sbjct: 108 NREVRDSYTLIIQATEKTLELEALTRVVVHILD--QNDLKPLFSPPSYRVTISEDMPLKS 165 Query: 479 RVGQVRATDKDLPQSS-LLYSISTGGASLQYPNVFWINPKTGELQLVTKVD 528 + +V ATD DL Q++ Y+ +T +F I+P +G + + K++ Sbjct: 166 PICKVTATDADLGQNAEFYYAFNTRS------EMFAIHPTSGVVTVAGKLN 210 >gi|9256614 protocadherin beta 3 precursor [Homo sapiens] Length = 796 Score = 118 bits (296), Expect = 2e-26 Identities = 141/613 (23%), Positives = 244/613 (39%), Gaps = 69/613 (11%) Query: 2 QEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQ 61 Q ++ + L G+++G E+ +VAE G + + L + + Q Sbjct: 13 QVLLLFVFLGGSLAGSESRRY-------SVAEEKEKGFLIANLAKDLGLRVEELAARGAQ 65 Query: 62 IVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTV 121 +V+ + F+++ +G E+L T P I QI +++ + ++ + Sbjct: 66 VVSKGN-KQHFQLSHQTGDLLLNEKLDREELCGPTEPCILHFQILLQNPLQFVTNELRII 124 Query: 122 QVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSF 181 V D + P F+ + HL I+E PG + + + D RN L + I+P F Sbjct: 125 DVND-HSPVFFENEM----HLKILESTLPGTVIPLGNAEDLDVGRN-SLQNYTITPNSHF 178 Query: 182 ----RMSANGTLFSTTELDFEAGHRS---FHLIVEVRDSGGLKASTELQVNI--VNLNDE 232 R +G + LD L + D G S Q+NI +++ND Sbjct: 179 HVLTRSRRDGRKYPELVLDKALDREEQPELSLTLTALDGGSPPRSGTAQINIQVLDINDN 238 Query: 233 VPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPS---HLLYSITTVSKYFMINQLT 289 P F P VLE +++ ++A D D F + ++ + K F +N +T Sbjct: 239 APEFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHASEEIRKTFQLNPIT 298 Query: 290 GTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFT 349 G +Q+ + ++ +A S EV ++ + GG + + V DVNDNP + Sbjct: 299 GDMQLVKYLNFEAIN-------SYEVDIEAKDGGGLSGKSTVIVQVVDVNDNPPELTLSS 351 Query: 350 FSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVL 409 + +PE + + L + F D N R ++ + + F P+ L Sbjct: 352 VNSPIPENSGETVLAV----FSVSDLDSGDNGRVMCSIENNLP----FFLKPSVENFYTL 403 Query: 410 I--GDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYV 467 + G LD E S +Y + I + D+ P K + +L S N+ F + SY Sbjct: 404 VSEGALDRETRS------EYNITITITDLGTPRLKTKYNITVLVSDVNDNAPAFTQISYT 457 Query: 468 FDVSERRPARTRVGQVRATDKDL-PQSSLLYS-ISTGGASLQYPNVFWINPKTGELQLVT 525 V E +G V ATD+D + + YS + L ++ IN G L + Sbjct: 458 LFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALR 517 Query: 526 KVDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVG 582 +D E + R+ AT+ +S V V +L+ ND NS F+ P Sbjct: 518 SLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDAND-------NSPFVLYP------ 564 Query: 583 TNIQNFKLTCTDL 595 +QN CT+L Sbjct: 565 --LQNGSAPCTEL 575 >gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens] Length = 799 Score = 118 bits (296), Expect = 2e-26 Identities = 157/634 (24%), Positives = 262/634 (41%), Gaps = 78/634 (12%) Query: 208 VEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDE- 266 V+ S L+ +E + + ++ND P F + TV E GT V N+TA D DD Sbjct: 139 VDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPV 198 Query: 267 -GFPSHLLYSITTVSKYFMINQLTGTIQVA-QRIDRDAGELRQNPTISLEVLVKDRPYGG 324 G + L+YSI YF I T I+ A +DR+A ++ + ++ GG Sbjct: 199 YGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREA---KEEYLVVIQAKDMGGHSGG 255 Query: 325 QENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFN 384 +T + DVNDNP + + VPE GT + + +D N + + Sbjct: 256 LSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTA---IGRVKANDQDIGENAQSS 312 Query: 385 FTMPSGVGSGSRFLQDPAGS--GKIVLIGDLDYENPSNLAAGNKYTVIIQVQDV--APPY 440 + + G G+ + A + G I L LD+E + YT+ ++ +V P + Sbjct: 313 YDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKS------YTLKVEAANVHIDPRF 366 Query: 441 -----YKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSL 495 +K+ V I+ +E P +F P+Y+ +V E + +GQV A D D+ S + Sbjct: 367 SGRGPFKDTATVKIVVEDADE-PPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPI 425 Query: 496 LYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQAT---NNEDTSSVTV 552 +SI F IN G++ L T +D E + + + I AT N+ S V V Sbjct: 426 RFSID---RHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPV 482 Query: 553 TVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVN 612 + +L+ ND P + Y L + K G IQ D + F YS+ P VN Sbjct: 483 AIKVLDVNDNAPEFA-SEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVN 541 Query: 613 N-HFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETG 671 N +FT N ++++ L + F+ K Y L + ++D L T Sbjct: 542 NPNFTIKKNEDNSLSILAKHNGFNR----QKQEVYLLPIIISDSG-------NPPLSSTS 590 Query: 672 TVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLG---SILLLGLLV 728 T+T+ + + + + + A+ +P +++G +IL +L+ Sbjct: 591 TLTIRVCGCSNDGVVQSC----------------NVEAYVLPIGLSMGALIAILACIILL 634 Query: 729 YLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGEAIDPVTGE 788 ++V+L + RH EPL K + E +++ + D EA D T + Sbjct: 635 LVIVVLFVTLRRH-------KNEPLIIKDDEDVRE-NIIRYDDEGGGEEDTEAFDIATLQ 686 Query: 789 TYE-FNSKTGARKWKDPLTQMPKWKESSHQGAAP 821 + N + K L MP+ QG AP Sbjct: 687 NPDGINGFLPRKDIKPDLQFMPR------QGLAP 714 Score = 71.2 bits (173), Expect = 4e-12 Identities = 88/380 (23%), Positives = 159/380 (41%), Gaps = 38/380 (10%) Query: 245 VLEELS-PGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAG 303 VLEE S P I+ D D + S F IN +TG I +R+DR Sbjct: 70 VLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDR--- 126 Query: 304 ELRQNPTISLEVL--VKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361 E + T++ + + +P E + V+D+NDN + VPE + G Sbjct: 127 EEKAEYTLTAQAVDWETSKPL---EPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILG 183 Query: 362 TLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNL 421 T + ++ DD + + +++ G F +P + + ++D E Sbjct: 184 TSVTNVTATDADDPVYGNSAKLVYSILEG---QPYFSIEPETAIIKTALPNMDRE----- 235 Query: 422 AAGNKYTVIIQVQDVA--PPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTR 479 A +Y V+IQ +D+ + + + N+ P F + Y F V E T Sbjct: 236 -AKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTA 294 Query: 480 VGQVRATDKDLPQSS-LLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILR 538 +G+V+A D+D+ +++ Y I G + + + G ++L +D ET Y L+ Sbjct: 295 IGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLK 354 Query: 539 IQATN------------NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586 ++A N +DT++V + ++E+ DE P+ + +Y L + + + + I Sbjct: 355 VEAANVHIDPRFSGRGPFKDTATVKI---VVEDADEPPVFSSPTYLLEVHENAALNSVIG 411 Query: 587 NFKLTCTDLDSSPRSFRYSI 606 D+ SSP R+SI Sbjct: 412 QVTARDPDITSSP--IRFSI 429 Score = 65.5 bits (158), Expect = 2e-10 Identities = 73/251 (29%), Positives = 114/251 (45%), Gaps = 34/251 (13%) Query: 112 GVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPG-FIYQVEAFDPEDTSRNIP 169 G++ LTV +TDVN+ PP+F +L H + E G I +V+A D +D N Sbjct: 255 GLSGTTTLTVTLTDVNDNPPKFAQSL---YHFSVPEDVVLGTAIGRVKAND-QDIGENAQ 310 Query: 170 LSYFLISPP-------KSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRD---------S 213 SY +I S + +G + LDFE +S+ L VE + Sbjct: 311 SSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFET-KKSYTLKVEAANVHIDPRFSGR 369 Query: 214 GGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLL 273 G K + +++ +V DE P F+SPT + V E + +++ +TA DPD P + Sbjct: 370 GPFKDTATVKI-VVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSP--IR 426 Query: 274 YSI---TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ 330 +SI T + + F IN G I +A +DR+ I+ E+ Q +R+ Sbjct: 427 FSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEI-----RNHSQISRVP 481 Query: 331 ITFIVEDVNDN 341 + V DVNDN Sbjct: 482 VAIKVLDVNDN 492 Score = 57.4 bits (137), Expect = 6e-08 Identities = 108/496 (21%), Positives = 204/496 (41%), Gaps = 56/496 (11%) Query: 121 VQVTDVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDT--SRNIPLSYFLIS 176 ++V D+N+ P+F L H + E + G + V A D +D + L Y ++ Sbjct: 155 IKVQDINDNAPEF---LNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILE 211 Query: 177 PPKSFRMSANGTLFSTT--ELDFEAGHRSFHLIVEVRD----SGGLKASTELQVNIVNLN 230 F + + T +D EA + ++++ +D SGGL +T L V + ++N Sbjct: 212 GQPYFSIEPETAIIKTALPNMDREA-KEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVN 270 Query: 231 DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPD-DEGFPSH---------LLYSITTVS 280 D P+F ++V E++ GT + + A D D E S L+ IT+ + Sbjct: 271 DNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDA 330 Query: 281 KYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEV--LVKDRPYGGQ---ENRIQITFIV 335 + G I++ + +D E +++ T+ +E + D + G+ ++ + +V Sbjct: 331 Q-----AQDGIIRLRKPLD---FETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVV 382 Query: 336 EDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGS 395 ED D P T+ + V E A +++ + D D + RF+ + + Sbjct: 383 EDA-DEPPVFSSPTYLLEVHENAALNSVIGQVT--ARDPDITSSPIRFSIDRHTDL---E 436 Query: 396 RFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPEN 455 R A GKI L LD E L+ + T+I ++ + V V I N Sbjct: 437 RQFNINADDGKITLATPLDRE----LSVWHNITII--ATEIRNHSQISRVPVAIKVLDVN 490 Query: 456 EFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWIN 515 + F F +P + + V A DKD P++ + S + PN Sbjct: 491 DNAPEFASEYEAFLCENGKPGQV-IQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKK 549 Query: 516 PKTGELQLVTK---VDCETTPIYILRI---QATNNEDTSSVTVTVNILEENDEKPICTPN 569 + L ++ K + + +Y+L I + N +S+ T+T+ + +++ + + N Sbjct: 550 NEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCN 609 Query: 570 SYFLALPVDLKVGTNI 585 LP+ L +G I Sbjct: 610 VEAYVLPIGLSMGALI 625 >gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo sapiens] Length = 2923 Score = 117 bits (294), Expect = 4e-26 Identities = 137/552 (24%), Positives = 239/552 (43%), Gaps = 46/552 (8%) Query: 118 VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLI 175 ++TVQV D+N+ P F ++ ++E G+ + V+A D D N L Y L Sbjct: 490 LVTVQVLDINDNAPIF---VSTPFQATVLESVPLGYLVLHVQAIDA-DAGDNARLEYRLA 545 Query: 176 SPPKSFRMSAN-GTLFSTTELDFEAGHRSFHLI-VEVRDSG--GLKASTELQVNIVNLND 231 F + N GT + + + + F+ VE RD G L AS + V ++++ND Sbjct: 546 GVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVND 605 Query: 232 EVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGT 291 P FT P + E+ + GT V ++A D D ++ + S T +++ + +Q G Sbjct: 606 NNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGG 665 Query: 292 IQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFS 351 + V+ + D RQ VL G +++ QI V D N + Q ++ Sbjct: 666 L-VSLALPLDYKLERQ------YVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYT 718 Query: 352 IMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIG 411 + V E GT ++ ++ D+ N R + M + +F D A +G + Sbjct: 719 VNVNEDRPAGTTVVLISA---TDEDTGENARITYFMEDSI---PQFRID-ADTGAVTTQA 771 Query: 412 DLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVS 471 +LDYE+ + YT+ I +D P + Y+ IL + N+ F R SY V Sbjct: 772 ELDYEDQVS------YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825 Query: 472 ERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531 E P T V Q+ ATD+D + ++ GG F + +G ++ + ++D E Sbjct: 826 EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGD--DGDGDFIVESTSGIVRTLRRLDREN 883 Query: 532 TPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF 588 Y+LR A + + + VTV +L+ ND P+ + + + + + +G + Sbjct: 884 VAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA-- 941 Query: 589 KLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYK 647 ++T TD D + Y I GN+ F +G LT+ D ++ +Y Sbjct: 942 RVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE------LTALVDL--DYEDRPEYV 993 Query: 648 LLVYVTDDNLMS 659 L++ T L+S Sbjct: 994 LVIQATSAPLVS 1005 Score = 102 bits (255), Expect = 1e-21 Identities = 97/383 (25%), Positives = 161/383 (42%), Gaps = 23/383 (6%) Query: 184 SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVY 243 S G + LD++ R + L V D G + + ++ VN+ + N P F S Sbjct: 662 SGGGLVSLALPLDYKL-ERQYVLAVTASD-GTRQDTAQIVVNVTDANTHRPVFQSSHYTV 719 Query: 244 TVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAG 303 V E+ GT V I+A D +D G + + Y + F I+ TG + +D + Sbjct: 720 NVNEDRPAGTTVVLISATD-EDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYE-- 776 Query: 304 ELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTL 363 + +L + +D + + + +V DVNDN + ++ V E T Sbjct: 777 ---DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTS 833 Query: 364 LLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAA 423 +L ++ D N R +T G F+ + SG + + LD EN + Sbjct: 834 VLQISA---TDRDSGLNGRVFYTFQGGDDGDGDFIVEST-SGIVRTLRRLDRENVA---- 885 Query: 424 GNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQV 483 +Y + D P + + V + N+ P +F++ + V E P V +V Sbjct: 886 --QYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARV 943 Query: 484 RATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQAT 542 ATD D + ++Y I G P VF ++ +GEL + +D E P Y+L IQAT Sbjct: 944 TATDPDEGTNAQIMYQIVEGNI----PEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT 999 Query: 543 NNEDTSSVTVTVNILEENDEKPI 565 + S TV V +L+ ND P+ Sbjct: 1000 SAPLVSRATVHVRLLDRNDNPPV 1022 Score = 100 bits (248), Expect = 8e-21 Identities = 143/592 (24%), Positives = 235/592 (39%), Gaps = 57/592 (9%) Query: 31 VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEV-----V 85 V EN P GT V ASL + P + +A + S +F + Sbjct: 190 VPENQPAGTPV--------ASLRAIDPDEGEAGRLEYTMDAL-FDSRSNQFFSLDPVTGA 240 Query: 86 TTGMEQLDFET-GPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE--PPQFQGNLAEGLHL 142 T E+LD ET ++F + + L LT+ VTD N+ P Q E L Sbjct: 241 VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLR- 299 Query: 143 YIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLI-----SPPKSFRMSANGTLFSTTELD 196 E G+ + V A D D N + Y L+ SP + F + + T Sbjct: 300 ---ENLEVGYEVLTVRATDG-DAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355 Query: 197 FEAGHRSFHLIVEV----RDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPG 252 S+ L VE RD G + + +++ + ND P+F+ V V E+++PG Sbjct: 356 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415 Query: 253 TIVANITAEDPDDEGFPSHLLYSITT--VSKYFMINQLTGTIQVAQRIDRDAGELRQNPT 310 V +TA D D+G + + YSI + F ++ TG + V +D E + T Sbjct: 416 APVLRVTASD-RDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDY---ETTKEYT 471 Query: 311 ISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKF 370 + + RP + + +T V D+NDN F V E G L+L + Sbjct: 472 LRVRAQDGGRPPLSNVSGL-VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAI 530 Query: 371 CFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVI 430 D N R + + +GVG F + G+G I + +LD E + Y+ Sbjct: 531 ---DADAGDNARLEYRL-AGVGHDFPFTIN-NGTGWISVAAELDREEV------DFYSFG 579 Query: 431 IQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL 490 ++ +D P + V + N+ F +P Y ++E T V V A D+D Sbjct: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD- 638 Query: 491 PQSSLLYSISTGGASLQYPNVFWINPKTGE--LQLVTKVDCETTPIYILRIQATNNEDTS 548 S + Y I++G N F I ++G + L +D + Y+L + A++ Sbjct: 639 AHSVITYQITSGNTR----NRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQD 694 Query: 549 SVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR 600 + + VN+ + N +P+ + Y + + D GT + T D + R Sbjct: 695 TAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENAR 746 Score = 96.3 bits (238), Expect = 1e-19 Identities = 101/401 (25%), Positives = 171/401 (42%), Gaps = 31/401 (7%) Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTV-----SKYFMINQL 288 P+F P+ TV E GT VA++ A DP DEG L Y++ + +++F ++ + Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDP-DEGEAGRLEYTMDALFDSRSNQFFSLDPV 237 Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKF 348 TG + A+ +DR+ T V +D + +T +V D ND+ ++ Sbjct: 238 TGAVTTAEELDRET-----KSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQ 292 Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGV-GSGSRFLQDPAGSGKI 407 + + E G +L + D PN + + G GS S + SG I Sbjct: 293 EYKESLRENLEVGYEVLTVRA---TDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVI 349 Query: 408 VLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYV 467 G +D E + + TV Q P V++ +N+ F YV Sbjct: 350 RTRGPVDREEVESY----QLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYV 405 Query: 468 FDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTK 526 V E V +V A+D+D ++++ YSI +G A Q F+++ +TG L +V+ Sbjct: 406 VQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQ----FYLDAQTGALDVVSP 461 Query: 527 VDCETTPIYILRIQATNNE----DTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVG 582 +D ETT Y LR++A + S VTV +L+ ND PI + + + +G Sbjct: 462 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521 Query: 583 TNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGS 623 + + + D + R Y + V + F F+ N G+ Sbjct: 522 YLVLHVQAIDADAGDNAR-LEYRL--AGVGHDFPFTINNGT 559 Score = 73.6 bits (179), Expect = 8e-13 Identities = 96/406 (23%), Positives = 159/406 (39%), Gaps = 45/406 (11%) Query: 295 AQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMV 354 A R+ + +L Q P + + GG+ R +VN P Q ++ V Sbjct: 140 APRLRCQSCKLAQAPGLRAGERSPEESLGGRRKR--------NVNTAPQF-QPPSYQATV 190 Query: 355 PERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSR--FLQDPAGSGKIVLIGD 412 PE GT + L D E R +TM + S S F DP +G + + Sbjct: 191 PENQPAGTPVASLRAI---DPDEGEAGRLEYTMDALFDSRSNQFFSLDPV-TGAVTTAEE 246 Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472 LD E S + + QD P + IL + N+ +F++ Y + E Sbjct: 247 LDRETKST------HVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRE 300 Query: 473 RRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531 V VRATD D P +++LY + G VF I+P++G ++ VD E Sbjct: 301 NLEVGYEVLTVRATDGDAPPNANILYRLLEGSGG-SPSEVFEIDPRSGVIRTRGPVDREE 359 Query: 532 TPIYILRIQATN-----NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586 Y L ++A++ +++ V +++ ++ND P + Y + + D+ G + Sbjct: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV- 418 Query: 587 NFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWD 645 ++T +D D + YSI GN F G+ L + S DY + + Sbjct: 419 -LRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGA----LDVVSPLDY----ETTKE 469 Query: 646 YKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPHPTTIITTTP 691 Y L V D + +G VT+ + I I +TP Sbjct: 470 YTLRVRAQDGG------RPPLSNVSGLVTVQVLDINDNAPIFVSTP 509 >gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] Length = 801 Score = 115 bits (289), Expect = 1e-25 Identities = 130/554 (23%), Positives = 231/554 (41%), Gaps = 75/554 (13%) Query: 216 LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDE--GFPSHLL 273 ++ +E + I ++ND P+F V TV E GT V +TA D DD G + ++ Sbjct: 145 MEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVV 204 Query: 274 YSITTVSKYFMINQLTGTIQVA-QRIDRDAGELRQNPTISLEVLVKDRPYGGQ----ENR 328 YSI YF ++ TG I+ A +DR+A E EV+++ + GGQ Sbjct: 205 YSILQGQPYFSVDSKTGVIRTALMNMDREAKEY-------YEVIIQAKDMGGQLGGLAGT 257 Query: 329 IQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMP 388 + + DVNDNP + + + V E + + + D E N +T+ Sbjct: 258 TTVNITLSDVNDNPPRFPQKHYQMSVLE---SAPISSTVGRVFAKDLDEGINAEMKYTIV 314 Query: 389 SGVGSGSRFLQ-DPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY------- 440 G G+ + + DP +G + + P + + YT ++V+ P Sbjct: 315 DGDGADAFDISTDPN-----FQVGIITVKKPLSFESKKSYT--LKVEGANPHLEMRFLNL 367 Query: 441 --YKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYS 498 +++ V+I +E P +F+ Y +V E T + + A D D+ +S+ YS Sbjct: 368 GPFQDTTTVHISVEDVDE-PPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYS 426 Query: 499 ISTGGASLQYPNVFWINPKTGELQLVTKVDCETTP---IYILRIQATNNEDTSSVTVTVN 555 I ++ F+++ TG L +D E I +L ++ N SV VT+ Sbjct: 427 IDRSSDPGRF---FYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIK 483 Query: 556 ILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNN-H 614 +L+ ND P P Y + + K G IQ D + + F YS+ P NN + Sbjct: 484 VLDVNDNAPE-FPRFYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPN 542 Query: 615 FTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVT 674 FT N + T +LT R + ++ +L+ + ++S TGT+T Sbjct: 543 FTIRDNQDN--TARILTRRSGFRQQEQSVFHLPILIADSGQPVLS---------STGTLT 591 Query: 675 LSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGSIL-----LLGLLVY 729 + + +++ SP A+ +P ++ G+++ + LLV Sbjct: 592 IQVCSCDDDGHVMSC----------------SPEAYMLPVSLSRGALIAILACIFVLLVL 635 Query: 730 LVVLLAKAIHRHCP 743 ++++L+ HR P Sbjct: 636 VLLILSMRRHRKQP 649 Score = 84.0 bits (206), Expect = 6e-16 Identities = 90/341 (26%), Positives = 147/341 (43%), Gaps = 37/341 (10%) Query: 283 FMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYG-GQENRIQITFIVEDVNDN 341 F I+ TG I QR+DR E R T+ + L DR G E + ++D+NDN Sbjct: 107 FTIDDTTGDIHAIQRLDR---EERAQYTLRAQAL--DRRTGRPMEPESEFIIKIQDINDN 161 Query: 342 PATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDP 401 + VPE + GT ++ + DD + + R ++ + G + Sbjct: 162 EPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYS----ILQGQPYFSVD 217 Query: 402 AGSGKI-VLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY--YKNNVYVYILTSPENEFP 458 + +G I + ++D E A Y VIIQ +D+ V I S N+ P Sbjct: 218 SKTGVIRTALMNMDRE------AKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNP 271 Query: 459 LIFDRPSYVFDVSERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPK 517 F + Y V E P + VG+V A D D + + Y+I G + + N + Sbjct: 272 PRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQ 331 Query: 518 TGELQLVTKVDCETTPIYILRIQATNN------------EDTSSVTVTVNILEENDEKPI 565 G + + + E+ Y L+++ N +DT++V ++V E+ DE P+ Sbjct: 332 VGIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISV---EDVDEPPV 388 Query: 566 CTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSI 606 P YF+ +P D+ +GT IQ ++ D D + S RYSI Sbjct: 389 FEPGFYFVEVPEDVAIGTTIQ--IISAKDPDVTNNSIRYSI 427 Score = 63.9 bits (154), Expect = 6e-10 Identities = 106/494 (21%), Positives = 204/494 (41%), Gaps = 52/494 (10%) Query: 121 VQVTDVNE-PPQFQGNLAEGLHLYIVERANP--GFIYQVEAFDPEDTS--RNIPLSYFLI 175 +++ D+N+ P+F +G ++ V +P + QV A D +D + + + Y ++ Sbjct: 153 IKIQDINDNEPKF----LDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSIL 208 Query: 176 SPPKSFRMSANGTLFSTTELDFEAGHRSFH-LIVEVRDSGG----LKASTELQVNIVNLN 230 F + + + T ++ + + ++ +I++ +D GG L +T + + + ++N Sbjct: 209 QGQPYFSVDSKTGVIRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVN 268 Query: 231 DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSIT--TVSKYFMI--- 285 D PRF +VLE + V + A+D DEG + + Y+I + F I Sbjct: 269 DNPPRFPQKHYQMSVLESAPISSTVGRVFAKDL-DEGINAEMKYTIVDGDGADAFDISTD 327 Query: 286 -NQLTGTIQVAQRIDRDAGELRQNPTISLE-----VLVKDRPYGGQENRIQITFIVEDVN 339 N G I V + + + E +++ T+ +E + ++ G ++ + VEDV+ Sbjct: 328 PNFQVGIITVKKPL---SFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDVD 384 Query: 340 DNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQ 399 + P F F + VPE A GT + ++ D + NN +++ G RF Sbjct: 385 EPPVFEPGFYF-VEVPEDVAIGTTIQIISA----KDPDVTNNSIRYSIDRSSDPG-RFFY 438 Query: 400 DPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPL 459 +G ++ LD E S + + + ++ P +V V I N+ Sbjct: 439 VDITTGALMTARPLDREEFS------WHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAP 492 Query: 460 IFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTG 519 F R Y V E A + V A D+D P++ + S + PN + + Sbjct: 493 EFPR-FYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDN 551 Query: 520 ELQLVTK--------VDCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSY 571 +++T+ PI I T ++T+ V +++ C+P +Y Sbjct: 552 TARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDDGHVMSCSPEAY 611 Query: 572 FLALPVDLKVGTNI 585 LPV L G I Sbjct: 612 M--LPVSLSRGALI 623 Score = 47.8 bits (112), Expect = 5e-05 Identities = 60/261 (22%), Positives = 107/261 (40%), Gaps = 20/261 (7%) Query: 115 DLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQ-VEAFDPEDTSRNIPLSYF 173 D + + V DV+EPP F+ + + E G Q + A DP+ T+ +I S Sbjct: 372 DTTTVHISVEDVDEPPVFEPGF---YFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSID 428 Query: 174 LISPPKSFRM--SANGTLFSTTELDFE--AGHRSFHLIVEVRDSGGLKASTELQVNIVNL 229 S P F G L + LD E + H L +E+ + + S + + ++++ Sbjct: 429 RSSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQV-GSVPVTIKVLDV 487 Query: 230 NDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLT 289 ND P F + V E G ++ ++A D DD H YS+ + N Sbjct: 488 NDNAPEFPRFYEAF-VCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEA----ANNPN 542 Query: 290 GTIQ-----VAQRIDRDAGELRQNPTI-SLEVLVKDRPYGGQENRIQITFIVEDVNDNPA 343 TI+ A+ + R +G +Q ++ L +L+ D + +T V +D+ Sbjct: 543 FTIRDNQDNTARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDDGH 602 Query: 344 TCQKFTFSIMVPERTAKGTLL 364 + M+P ++G L+ Sbjct: 603 VMSCSPEAYMLPVSLSRGALI 623 >gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precursor [Homo sapiens] Length = 837 Score = 115 bits (287), Expect = 2e-25 Identities = 140/602 (23%), Positives = 246/602 (40%), Gaps = 59/602 (9%) Query: 5 IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVN 64 ++L LG + G A + +V E + G+ V S L + +IV Sbjct: 15 LLLCIFLGTLRGFRARQIRY-----SVPEETEKGSFVGNISKDLGLEPRELAKRGVRIV- 68 Query: 65 SNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT 124 S T+ F VN SG+ E+L ++++ V+D + + ++V + + Sbjct: 69 SRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDIN 128 Query: 125 DVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMS 184 D P FQ + E + + E A PG + + D N SY L SP F + Sbjct: 129 D--NAPSFQEDEVE---IKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-SPNNYFSLQ 182 Query: 185 ANG----------TLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDE 232 G L + + + EA H L++ D G K + ++V ++++ND Sbjct: 183 LRGRTDGAKNPELVLEGSLDREKEAAHL---LLLTALDGGDPIRKGAVPIRVVVLDVNDH 239 Query: 233 VPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI----TTVSKYFMINQL 288 +P FT +V E +S GT V + A DP DEG ++YS + S+ F ++ Sbjct: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDP-DEGINGEVMYSFRNMESKASEIFQLDSQ 298 Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKF 348 TG +QV +D + E+ ++ + GG + V DVNDN Sbjct: 299 TGEVQVRGSLDFEKYRF-------YEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITIT 351 Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408 + + E + GT++ LN D N + + +P+ + + + K++ Sbjct: 352 SSINSILENSPPGTVIALLN---VQDQDSGENGQVSCFIPNHL--PFKLEKTYGNYYKLI 406 Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468 LD E Y + + D P +V++ + +N+ P +F SY Sbjct: 407 TSRVLDRE------LVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA 460 Query: 469 DVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGA-SLQYPNVFWINPKTGELQLVTK 526 + E P + V A D D Q++L+ YS++ + + IN TG L + Sbjct: 461 YIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS 520 Query: 527 VDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGT 583 D E LR+ A ++ D +S+V++++ +L++ND P + ALP D G Sbjct: 521 FDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDN----APEILYPALPTDGSTGV 576 Query: 584 NI 585 + Sbjct: 577 EL 578 Score = 81.3 bits (199), Expect = 4e-15 Identities = 101/428 (23%), Positives = 182/428 (42%), Gaps = 52/428 (12%) Query: 119 LTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176 + V V DVN+ P F ++ + + E + G + V A DP++ + F Sbjct: 229 IRVVVLDVNDHIPMFTQSV---YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNM 285 Query: 177 PPKSFRM----SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDE 232 K+ + S G + LDFE +R + + ++ +D GGL +T + + +V++ND Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEK-YRFYEMEIQGQDGGGLFTTTTMLITVVDVNDN 344 Query: 233 VPRFTSPTRVYTVLEELSPGTIVA--NITAEDPDDEG-----FPSHLLYSI-TTVSKYFM 284 P T + + ++LE PGT++A N+ +D + G P+HL + + T Y+ Sbjct: 345 APEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYK 404 Query: 285 INQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPAT 344 + +T + +DR EL Q+ I+L + P E + + V D NDNP Sbjct: 405 L--ITSRV-----LDR---ELVQSYNITLTATDQGSPPLSAETHVWLN--VADDNDNPPV 452 Query: 345 CQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSG---SRFLQDP 401 ++S +PE +G + + D DS+ N +++ G S ++ Sbjct: 453 FPHSSYSAYIPENNPRGASIFSVT--ALDPDSK-QNALVTYSLTDDTVQGVPLSSYVSIN 509 Query: 402 AGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIF 461 + +G + + DYE +L + + +D P +NV + + +N+ Sbjct: 510 SNTGVLYALQSFDYEQFRDL------ELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEI 563 Query: 462 DRPSYVFDVS---ERRPARTRVG----QVRATDKDLPQSSLLYSISTGGASLQYPNVFWI 514 P+ D S E P G +V A DKD Q++ L S P +F + Sbjct: 564 LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWL---SYRLLKASEPGLFAV 620 Query: 515 NPKTGELQ 522 TGE++ Sbjct: 621 GEHTGEVR 628 Score = 41.2 bits (95), Expect = 0.004 Identities = 57/245 (23%), Positives = 93/245 (37%), Gaps = 13/245 (5%) Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413 VPE T KG+ + +++K + E G F +P SG ++ G + Sbjct: 36 VPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSR---GKTQLFAVNPR-SGSLITAGRI 91 Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473 D E + + + V+D Y V V I+ +N F VSE Sbjct: 92 DREELCETVSSCFLNMELLVEDTLKIY---GVEVEIIDINDNAPS--FQEDEVEIKVSEH 146 Query: 474 RPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532 R A D D+ +SL Y +S K EL L +D E Sbjct: 147 AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKE 206 Query: 533 PIYILRIQATNNEDT---SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK 589 ++L + A + D +V + V +L+ ND P+ T + Y +++P ++ GT + Sbjct: 207 AAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVN 266 Query: 590 LTCTD 594 T D Sbjct: 267 ATDPD 271 >gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precursor [Homo sapiens] Length = 935 Score = 115 bits (287), Expect = 2e-25 Identities = 140/602 (23%), Positives = 246/602 (40%), Gaps = 59/602 (9%) Query: 5 IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVN 64 ++L LG + G A + +V E + G+ V S L + +IV Sbjct: 15 LLLCIFLGTLRGFRARQIRY-----SVPEETEKGSFVGNISKDLGLEPRELAKRGVRIV- 68 Query: 65 SNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT 124 S T+ F VN SG+ E+L ++++ V+D + + ++V + + Sbjct: 69 SRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDIN 128 Query: 125 DVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMS 184 D P FQ + E + + E A PG + + D N SY L SP F + Sbjct: 129 D--NAPSFQEDEVE---IKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-SPNNYFSLQ 182 Query: 185 ANG----------TLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDE 232 G L + + + EA H L++ D G K + ++V ++++ND Sbjct: 183 LRGRTDGAKNPELVLEGSLDREKEAAHL---LLLTALDGGDPIRKGAVPIRVVVLDVNDH 239 Query: 233 VPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI----TTVSKYFMINQL 288 +P FT +V E +S GT V + A DP DEG ++YS + S+ F ++ Sbjct: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDP-DEGINGEVMYSFRNMESKASEIFQLDSQ 298 Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKF 348 TG +QV +D + E+ ++ + GG + V DVNDN Sbjct: 299 TGEVQVRGSLDFEKYRF-------YEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITIT 351 Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408 + + E + GT++ LN D N + + +P+ + + + K++ Sbjct: 352 SSINSILENSPPGTVIALLN---VQDQDSGENGQVSCFIPNHL--PFKLEKTYGNYYKLI 406 Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468 LD E Y + + D P +V++ + +N+ P +F SY Sbjct: 407 TSRVLDRE------LVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA 460 Query: 469 DVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGA-SLQYPNVFWINPKTGELQLVTK 526 + E P + V A D D Q++L+ YS++ + + IN TG L + Sbjct: 461 YIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS 520 Query: 527 VDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGT 583 D E LR+ A ++ D +S+V++++ +L++ND P + ALP D G Sbjct: 521 FDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDN----APEILYPALPTDGSTGV 576 Query: 584 NI 585 + Sbjct: 577 EL 578 Score = 81.3 bits (199), Expect = 4e-15 Identities = 101/428 (23%), Positives = 182/428 (42%), Gaps = 52/428 (12%) Query: 119 LTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176 + V V DVN+ P F ++ + + E + G + V A DP++ + F Sbjct: 229 IRVVVLDVNDHIPMFTQSV---YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNM 285 Query: 177 PPKSFRM----SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDE 232 K+ + S G + LDFE +R + + ++ +D GGL +T + + +V++ND Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEK-YRFYEMEIQGQDGGGLFTTTTMLITVVDVNDN 344 Query: 233 VPRFTSPTRVYTVLEELSPGTIVA--NITAEDPDDEG-----FPSHLLYSI-TTVSKYFM 284 P T + + ++LE PGT++A N+ +D + G P+HL + + T Y+ Sbjct: 345 APEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYK 404 Query: 285 INQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPAT 344 + +T + +DR EL Q+ I+L + P E + + V D NDNP Sbjct: 405 L--ITSRV-----LDR---ELVQSYNITLTATDQGSPPLSAETHVWLN--VADDNDNPPV 452 Query: 345 CQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSG---SRFLQDP 401 ++S +PE +G + + D DS+ N +++ G S ++ Sbjct: 453 FPHSSYSAYIPENNPRGASIFSVT--ALDPDSK-QNALVTYSLTDDTVQGVPLSSYVSIN 509 Query: 402 AGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIF 461 + +G + + DYE +L + + +D P +NV + + +N+ Sbjct: 510 SNTGVLYALQSFDYEQFRDL------ELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEI 563 Query: 462 DRPSYVFDVS---ERRPARTRVG----QVRATDKDLPQSSLLYSISTGGASLQYPNVFWI 514 P+ D S E P G +V A DKD Q++ L S P +F + Sbjct: 564 LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWL---SYRLLKASEPGLFAV 620 Query: 515 NPKTGELQ 522 TGE++ Sbjct: 621 GEHTGEVR 628 Score = 41.2 bits (95), Expect = 0.004 Identities = 57/245 (23%), Positives = 93/245 (37%), Gaps = 13/245 (5%) Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413 VPE T KG+ + +++K + E G F +P SG ++ G + Sbjct: 36 VPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSR---GKTQLFAVNPR-SGSLITAGRI 91 Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473 D E + + + V+D Y V V I+ +N F VSE Sbjct: 92 DREELCETVSSCFLNMELLVEDTLKIY---GVEVEIIDINDNAPS--FQEDEVEIKVSEH 146 Query: 474 RPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532 R A D D+ +SL Y +S K EL L +D E Sbjct: 147 AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKE 206 Query: 533 PIYILRIQATNNEDT---SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK 589 ++L + A + D +V + V +L+ ND P+ T + Y +++P ++ GT + Sbjct: 207 AAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVN 266 Query: 590 LTCTD 594 T D Sbjct: 267 ATDPD 271 >gi|14196455 protocadherin gamma subfamily A, 11 isoform 3 precursor [Homo sapiens] Length = 750 Score = 115 bits (287), Expect = 2e-25 Identities = 140/602 (23%), Positives = 246/602 (40%), Gaps = 59/602 (9%) Query: 5 IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVN 64 ++L LG + G A + +V E + G+ V S L + +IV Sbjct: 15 LLLCIFLGTLRGFRARQIRY-----SVPEETEKGSFVGNISKDLGLEPRELAKRGVRIV- 68 Query: 65 SNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT 124 S T+ F VN SG+ E+L ++++ V+D + + ++V + + Sbjct: 69 SRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDIN 128 Query: 125 DVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMS 184 D P FQ + E + + E A PG + + D N SY L SP F + Sbjct: 129 D--NAPSFQEDEVE---IKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-SPNNYFSLQ 182 Query: 185 ANG----------TLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDE 232 G L + + + EA H L++ D G K + ++V ++++ND Sbjct: 183 LRGRTDGAKNPELVLEGSLDREKEAAHL---LLLTALDGGDPIRKGAVPIRVVVLDVNDH 239 Query: 233 VPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI----TTVSKYFMINQL 288 +P FT +V E +S GT V + A DP DEG ++YS + S+ F ++ Sbjct: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDP-DEGINGEVMYSFRNMESKASEIFQLDSQ 298 Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKF 348 TG +QV +D + E+ ++ + GG + V DVNDN Sbjct: 299 TGEVQVRGSLDFEKYRF-------YEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITIT 351 Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408 + + E + GT++ LN D N + + +P+ + + + K++ Sbjct: 352 SSINSILENSPPGTVIALLN---VQDQDSGENGQVSCFIPNHL--PFKLEKTYGNYYKLI 406 Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468 LD E Y + + D P +V++ + +N+ P +F SY Sbjct: 407 TSRVLDRE------LVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA 460 Query: 469 DVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGA-SLQYPNVFWINPKTGELQLVTK 526 + E P + V A D D Q++L+ YS++ + + IN TG L + Sbjct: 461 YIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS 520 Query: 527 VDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGT 583 D E LR+ A ++ D +S+V++++ +L++ND P + ALP D G Sbjct: 521 FDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDN----APEILYPALPTDGSTGV 576 Query: 584 NI 585 + Sbjct: 577 EL 578 Score = 80.5 bits (197), Expect = 6e-15 Identities = 101/426 (23%), Positives = 180/426 (42%), Gaps = 52/426 (12%) Query: 119 LTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176 + V V DVN+ P F ++ + + E + G + V A DP++ + F Sbjct: 229 IRVVVLDVNDHIPMFTQSV---YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNM 285 Query: 177 PPKSFRM----SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDE 232 K+ + S G + LDFE +R + + ++ +D GGL +T + + +V++ND Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEK-YRFYEMEIQGQDGGGLFTTTTMLITVVDVNDN 344 Query: 233 VPRFTSPTRVYTVLEELSPGTIVA--NITAEDPDDEG-----FPSHLLYSI-TTVSKYFM 284 P T + + ++LE PGT++A N+ +D + G P+HL + + T Y+ Sbjct: 345 APEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYK 404 Query: 285 INQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPAT 344 + +T + +DR EL Q+ I+L + P E + + V D NDNP Sbjct: 405 L--ITSRV-----LDR---ELVQSYNITLTATDQGSPPLSAETHVWLN--VADDNDNPPV 452 Query: 345 CQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSG---SRFLQDP 401 ++S +PE +G + + D DS+ N +++ G S ++ Sbjct: 453 FPHSSYSAYIPENNPRGASIFSVT--ALDPDSK-QNALVTYSLTDDTVQGVPLSSYVSIN 509 Query: 402 AGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIF 461 + +G + + DYE +L + + +D P +NV + + +N+ Sbjct: 510 SNTGVLYALQSFDYEQFRDL------ELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEI 563 Query: 462 DRPSYVFDVS---ERRPARTRVG----QVRATDKDLPQSSLLYSISTGGASLQYPNVFWI 514 P+ D S E P G +V A DKD Q++ L S P +F + Sbjct: 564 LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWL---SYRLLKASEPGLFAV 620 Query: 515 NPKTGE 520 TGE Sbjct: 621 GEHTGE 626 Score = 41.2 bits (95), Expect = 0.004 Identities = 57/245 (23%), Positives = 93/245 (37%), Gaps = 13/245 (5%) Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413 VPE T KG+ + +++K + E G F +P SG ++ G + Sbjct: 36 VPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSR---GKTQLFAVNPR-SGSLITAGRI 91 Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473 D E + + + V+D Y V V I+ +N F VSE Sbjct: 92 DREELCETVSSCFLNMELLVEDTLKIY---GVEVEIIDINDNAPS--FQEDEVEIKVSEH 146 Query: 474 RPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532 R A D D+ +SL Y +S K EL L +D E Sbjct: 147 AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKE 206 Query: 533 PIYILRIQATNNEDT---SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK 589 ++L + A + D +V + V +L+ ND P+ T + Y +++P ++ GT + Sbjct: 207 AAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVN 266 Query: 590 LTCTD 594 T D Sbjct: 267 ATDPD 271 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.135 0.396 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 35,785,776 Number of Sequences: 37866 Number of extensions: 1703753 Number of successful extensions: 6605 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 188 Number of HSP's successfully gapped in prelim test: 22 Number of HSP's that attempted gapping in prelim test: 3678 Number of HSP's gapped (non-prelim): 843 length of query: 885 length of database: 18,247,518 effective HSP length: 111 effective length of query: 774 effective length of database: 14,044,392 effective search space: 10870359408 effective search space used: 10870359408 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.