Guide to the Human Genome
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Search of human proteins with 40255133

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40255133 hypothetical protein LOC222256 [Homo sapiens]
         (885 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40255133 hypothetical protein LOC222256 [Homo sapiens]            1779   0.0  
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]           149   1e-35
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]            139   2e-32
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]      130   4e-30
gi|203097724 cadherin-like 29 [Homo sapiens]                          127   3e-29
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]           124   3e-28
gi|11056063 protocadherin gamma subfamily A, 7 isoform 1 precurs...   124   5e-28
gi|14196477 protocadherin gamma subfamily A, 7 isoform 2 precurs...   124   5e-28
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi...   122   1e-27
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap...   122   1e-27
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi...   122   1e-27
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi...   122   1e-27
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi...   122   1e-27
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi...   122   1e-27
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi...   122   1e-27
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi...   122   1e-27
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi...   122   1e-27
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi...   122   1e-27
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi...   122   1e-27
gi|16933557 dachsous 1 precursor [Homo sapiens]                       122   1e-27
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi...   120   4e-27
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]            119   1e-26
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]           119   1e-26
gi|9256614 protocadherin beta 3 precursor [Homo sapiens]              118   2e-26
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]           118   2e-26
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ...   117   4e-26
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]          115   1e-25
gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precur...   115   2e-25
gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precur...   115   2e-25
gi|14196455 protocadherin gamma subfamily A, 11 isoform 3 precur...   115   2e-25

>gi|40255133 hypothetical protein LOC222256 [Homo sapiens]
          Length = 885

 Score = 1779 bits (4609), Expect = 0.0
 Identities = 885/885 (100%), Positives = 885/885 (100%)

Query: 1   MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP 60
           MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP
Sbjct: 1   MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP 60

Query: 61  QIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT 120
           QIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT
Sbjct: 61  QIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT 120

Query: 121 VQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS 180
           VQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS
Sbjct: 121 VQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS 180

Query: 181 FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPT 240
           FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPT
Sbjct: 181 FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPT 240

Query: 241 RVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDR 300
           RVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDR
Sbjct: 241 RVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDR 300

Query: 301 DAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAK 360
           DAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAK
Sbjct: 301 DAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAK 360

Query: 361 GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN 420
           GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN
Sbjct: 361 GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN 420

Query: 421 LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV 480
           LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV
Sbjct: 421 LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV 480

Query: 481 GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQ 540
           GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQ
Sbjct: 481 GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQ 540

Query: 541 ATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR 600
           ATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR
Sbjct: 541 ATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR 600

Query: 601 SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSD 660
           SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSD
Sbjct: 601 SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSD 660

Query: 661 RKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGS 720
           RKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGS
Sbjct: 661 RKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGS 720

Query: 721 ILLLGLLVYLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGE 780
           ILLLGLLVYLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGE
Sbjct: 721 ILLLGLLVYLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGE 780

Query: 781 AIDPVTGETYEFNSKTGARKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEE 840
           AIDPVTGETYEFNSKTGARKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEE
Sbjct: 781 AIDPVTGETYEFNSKTGARKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEE 840

Query: 841 DELSGKAWAEDAGLGSRNEGGKLGNPKNRNPAFMNRAYPKPHPGK 885
           DELSGKAWAEDAGLGSRNEGGKLGNPKNRNPAFMNRAYPKPHPGK
Sbjct: 841 DELSGKAWAEDAGLGSRNEGGKLGNPKNRNPAFMNRAYPKPHPGK 885


>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
          Length = 4588

 Score =  149 bits (376), Expect = 1e-35
 Identities = 148/526 (28%), Positives = 249/526 (47%), Gaps = 44/526 (8%)

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPG-FIYQVEAFDPEDTSRNIPLSYFLI 175
            ++ V+V D N+  P  +  L       I E   PG  I Q+ A D  D   N  ++Y L+
Sbjct: 3008 IVEVKVLDANDNSPVCEKTLYSDT---IPEDVLPGKLIMQISATDA-DIRSNAEITYTLL 3063

Query: 176  -SPPKSFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEV 233
             S  + F+++ + G L ++T LD E     +HL+V   D GG      + + + ++ND  
Sbjct: 3064 GSGAEKFKLNPDTGELKTSTPLDREE-QAVYHLLVRATDGGGRFCQASIVLTLEDVNDNA 3122

Query: 234  PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYS-ITTVSKYFMINQLTGTI 292
            P F++     TV E   PGT++  + A D  D G    +LYS I +    F IN+L+G I
Sbjct: 3123 PEFSADPYAITVFENTEPGTLLTRVQATDA-DAGLNRKILYSLIDSADGQFSINELSGII 3181

Query: 293  QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352
            Q+ + +DR   EL+   T+SL+ + +  P         I  ++ D+NDNP   +   +  
Sbjct: 3182 QLEKPLDR---ELQAVYTLSLKAVDQGLPRRLTATGTVIVSVL-DINDNPPVFEYREYGA 3237

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412
             V E    GT +L +  +    D EA N    +++ SG   G +F  D + +G + +I +
Sbjct: 3238 TVSEDILVGTEVLQV--YAASRDIEA-NAEITYSIISGNEHG-KFSID-SKTGAVFIIEN 3292

Query: 413  LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472
            LDYE      + ++Y + ++  D   P   +   V +  +  N+   +F + +Y   +SE
Sbjct: 3293 LDYE------SSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISE 3346

Query: 473  RRPARTRVGQVRATDKDLPQSS-LLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531
                   V  V A D D P +S + YSI  G       + F I+P  GE+++   +D ET
Sbjct: 3347 DAVLEQSVITVMADDADGPSNSHIHYSIIDGNQG----SSFTIDPVRGEVKVTKLLDRET 3402

Query: 532  TPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF 588
               Y L +QA++N      ++ TV +++ + ND  P+ +  +Y + +  +  VG ++   
Sbjct: 3403 ISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSV--L 3460

Query: 589  KLTCTDLDSSPRS--FRYSIGPGNVNNHFTFSPNAGSNVTRLLLTS 632
            +L  TD DSS     F ++I  GN    F  +P        +LLTS
Sbjct: 3461 QLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQG------VLLTS 3500



 Score =  117 bits (293), Expect = 5e-26
 Identities = 144/606 (23%), Positives = 255/606 (42%), Gaps = 67/606 (11%)

Query: 89   MEQLDFETGPNIFDLQIYVKDE---VGVTDLQVLTVQVTDVNE---PPQFQGNLAEGLHL 142
            ++QLDFE    +++L +  KD+   V ++    + V+V DVNE   PP F   + +G   
Sbjct: 986  VQQLDFEK-KQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGT-- 1042

Query: 143  YIVERANPGFIYQVEAFDPEDTSRNIPLSYFLI--SPPKSFRMSAN-GTLFSTTELDFEA 199
             + E A  G +    +   ED  R+  + Y +   S    F++    G + ++  LD E+
Sbjct: 1043 -VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101

Query: 200  GHRSFHLIVEVRDSGGLKAST--ELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVAN 257
                + L V   D G +  S+  E+ + + ++ND  P+ + P     ++E       V  
Sbjct: 1102 TSH-YWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQ 1160

Query: 258  ITAEDPDDEGFPSHLLYSITTVSK--YFMINQLTGTIQVAQR-IDRDAGELRQNPTISLE 314
            I A DPD       L+Y IT+ +   +F I+  TG I    R +DR+     Q     LE
Sbjct: 1161 IEAFDPDSSS-NDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDRE-----QQDEHILE 1214

Query: 315  VLVKDRPYGGQENRIQITFIVEDVNDN-PATCQKFTFSIMVPERTA----KGTLLLDLNK 369
            V V D     +    ++   + D NDN P   QKF + I +PER      +      L  
Sbjct: 1215 VTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKF-YKIRLPEREKPDRERNARREPLYH 1273

Query: 370  FCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTV 429
                D  E PN   ++++  G   G  F++   G             +    +A  +Y +
Sbjct: 1274 VIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG-----------VVSSKRFSAAGEYDI 1322

Query: 430  I-IQVQDVAPPYYKNNVYVYI--LTSPENEF-PLIFDRPSYVFDVSERRPARTRVGQVRA 485
            + I+  D   P   +   ++I  ++ P+    P+ F+   + F V E  P    +G +  
Sbjct: 1323 LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV 1382

Query: 486  TDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNE 545
                +P    L+   TGG    Y + F ++  TG + +   +D E    Y L ++AT+  
Sbjct: 1383 EPPGIP----LWFDITGG---NYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGT 1435

Query: 546  DTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR---SF 602
             T    V + +++ ND +P  + + Y + +P D    T I   +++  D D   +   + 
Sbjct: 1436 TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEI--LQISAVDQDEKNKLIYTL 1493

Query: 603  RYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRK 662
            + S  P ++   F   P  GS    L  + + D+    + +  + L V V D ++   R 
Sbjct: 1494 QSSRDPLSLKK-FRLDPATGS----LYTSEKLDH----EAVHQHTLTVMVRDQDVPVKRN 1544

Query: 663  KAEALV 668
             A  +V
Sbjct: 1545 FARIVV 1550



 Score =  115 bits (287), Expect = 2e-25
 Identities = 130/543 (23%), Positives = 225/543 (41%), Gaps = 38/543 (6%)

Query: 57   PGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDL 116
            P F  I+N +     F+++  SG    V++T     D E     FD+ + V +E   + +
Sbjct: 2011 PLFYHILNPD---RRFKISRTSG----VLSTTGTPFDREQ-QEAFDVVVEVTEEHKPSAV 2062

Query: 117  QVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANP--GFIYQVEAFDPEDTSRNIPLSYFL 174
              + V+V  + E       +   L  Y V + +   G + +       D+ RN  + Y+L
Sbjct: 2063 AHVVVKV--IVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYL 2120

Query: 175  ISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVP 234
                + F++   G +    + + +  ++ + + V  +D G    S E+ V I  +N  +P
Sbjct: 2121 KEHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMP 2180

Query: 235  RFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FMINQLTGTI 292
             F  P     + E +   + V ++ A  P  EG    + YSIT    +  F IN  TG I
Sbjct: 2181 VFEKPFYSAEIAESIQVHSPVVHVQANSP--EGL--KVFYSITDGDPFSQFTINFNTGVI 2236

Query: 293  QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352
             V   +D +A     +P   L +   D    G    + +  IV+D+NDNP    + ++++
Sbjct: 2237 NVIAPLDFEA-----HPAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAV 2290

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412
             + E +  GT ++ +     D DSE PN   ++ M              + +G I L+  
Sbjct: 2291 TLSEASVIGTSVVQVR--ATDSDSE-PNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRT 2347

Query: 413  LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472
            LDYE         ++T+ ++  D   P   ++V V +  +  N+ P +F++  Y   +SE
Sbjct: 2348 LDYEQ------SRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401

Query: 473  RRPARTRVGQVRATDKDLPQ-SSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531
              P    V  V+A D D      L YSI +G         F I+  TG + L        
Sbjct: 2402 HAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKH----FVIDSATGIITLSNLHRHAL 2457

Query: 532  TPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLT 591
             P Y L +  ++    SS  V V ++  N   P    N Y + L  +  + T +   K T
Sbjct: 2458 KPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTT 2517

Query: 592  CTD 594
              D
Sbjct: 2518 DGD 2520



 Score =  113 bits (282), Expect = 9e-25
 Identities = 115/456 (25%), Positives = 204/456 (44%), Gaps = 41/456 (8%)

Query: 187  GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVL 246
            GT+     LD E    +++L VE  D G     T++ + +++ ND  P+F++      + 
Sbjct: 1409 GTIIVAKPLDAEQ-KSNYNLTVEATD-GTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIP 1466

Query: 247  EELSPGTIVANITAEDPDDEGFPSHLLYSITTVS-----KYFMINQLTGTIQVAQRIDRD 301
            E+ +P T +  I+A D D++   + L+Y++ +       K F ++  TG++  ++++D +
Sbjct: 1467 EDTAPETEILQISAVDQDEK---NKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHE 1523

Query: 302  AGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361
            A  + Q+   +L V+V+D+    + N  +I   V D ND+       ++   V E  A G
Sbjct: 1524 A--VHQH---TLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVG 1578

Query: 362  TLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNL 421
            +++L +      D  +  N    +++ SG   G+ F+ DP   G I    +LD  N +  
Sbjct: 1579 SVVLQVTAL---DKDKGKNAEVLYSIESG-NIGNSFMIDPV-LGSIKTAKELDRSNQA-- 1631

Query: 422  AAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVG 481
                +Y ++++  D   P       V I  +  +     F    Y  ++SE     + VG
Sbjct: 1632 ----EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVG 1687

Query: 482  QVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA 541
             V A      QSS++Y I  G       + F INP +G +     +D ET PIY L IQ 
Sbjct: 1688 MVTAHS----QSSVVYEIKDGNTG----DAFDINPHSGTIITQKALDFETLPIYTLIIQG 1739

Query: 542  TNNEDTS-SVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI---QNFKLTCTDLDS 597
            TN    S + TV V++ +END  P+     Y   +     + + +   +N  L     D+
Sbjct: 1740 TNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADA 1799

Query: 598  SPRS---FRYSIGPGNVNNHFTFSPNAGSNVTRLLL 630
               S     Y I   +V+ +F    + G+  T L L
Sbjct: 1800 DKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSL 1835



 Score =  100 bits (250), Expect = 5e-21
 Identities = 110/437 (25%), Positives = 186/437 (42%), Gaps = 40/437 (9%)

Query: 163  DTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEAGHRSFHLIVEVRDSG--GLK 217
            D   N  ++Y +IS  +  + S +   G +F    LD+E+ H  ++L VE  D G   L 
Sbjct: 3258 DIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHE-YYLTVEATDGGTPSLS 3316

Query: 218  ASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSIT 277
                + VN+ ++ND  P F+  T    + E+      V  + A+D D     SH+ YSI 
Sbjct: 3317 DVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPS-NSHIHYSII 3375

Query: 278  TVSK--YFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFI- 334
              ++   F I+ + G ++V + +DR+        TIS   L       G   R+  T + 
Sbjct: 3376 DGNQGSSFTIDPVRGEVKVTKLLDRE--------TISGYTLTVQASDNGSPPRVNTTTVN 3427

Query: 335  --VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVG 392
              V DVNDN     +  +S+++ E    G  +L L     D+DS      F FT+ +G  
Sbjct: 3428 IDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQL--VVTDEDSSHNGPPFFFTIVTG-N 3484

Query: 393  SGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTS 452
                F  +P G    VL+     +        + Y + ++V D   P   +  Y+ I   
Sbjct: 3485 DEKAFEVNPQG----VLLTSSAIKRKEK----DHYLLQVKVADNGKPQLSSLTYIDIRVI 3536

Query: 453  PENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVF 512
             E+ +P            S    +   +G++ ATD+D+   +L YS+       Q  N+F
Sbjct: 3537 EESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQDV-YDTLTYSLDP-----QMDNLF 3590

Query: 513  WINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYF 572
             ++   G+L    K+D      Y+L +  T+ + T+   +TV+I +   E    T    F
Sbjct: 3591 SVSSTGGKLIAHKKLDIGQ---YLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTIAIRF 3647

Query: 573  LALPVDLKVGTNIQNFK 589
              L  +  VG   +NF+
Sbjct: 3648 ANLTPEEFVGDYWRNFQ 3664



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 136/568 (23%), Positives = 231/568 (40%), Gaps = 80/568 (14%)

Query: 119 LTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGF----------IYQVE--AFDPEDTS- 165
           LT+Q  D   PPQF         + ++   +P F          +Y+ E   F P +T  
Sbjct: 334 LTLQAKDKGTPPQFSS-------VKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPV 386

Query: 166 ---RNIP----LSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKA 218
              + IP    L Y   S P   + S N      + L+     ++ H  +EV  S   KA
Sbjct: 387 VMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS-DRKA 445

Query: 219 STELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITT 278
           ST++ V ++  N   P FT         E +  GT V +++A DP DEG   ++ YSI  
Sbjct: 446 STKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDP-DEGENGYVTYSIAN 504

Query: 279 VSKY-FMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVED 337
           ++   F I+  TG +  ++ +D +   + +  T+ +       PY  +E  +  T  + +
Sbjct: 505 LNHVPFAIDHFTGAVSTSENLDYEL--MPRVYTLRIRASDWGLPY-RREVEVLATITLNN 561

Query: 338 VNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDD------DSEAPN--NRFNFTMPS 389
           +NDN    +K      +P     G  +  ++    D+        EA N  + F+    S
Sbjct: 562 LNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNS 621

Query: 390 GVGSGSRFLQDPAG------SGKIVLIGDLDYENPSNL---AAGNKYTVIIQVQD--VAP 438
           GV S  R L D  G      S +I      ++  P  +    A +   V +Q ++  VA 
Sbjct: 622 GVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAK 681

Query: 439 PYYKNNVYVYILTSPENEFPLIFDRPSY-------------VFDVSERRPARTRVGQVRA 485
              +  +    L +      + FD  S                 V E +P  + V  + +
Sbjct: 682 MLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNS 741

Query: 486 TDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN- 543
           TD D      L+Y++S G       + F I+ +TG L++++ +D ETT  Y L I   + 
Sbjct: 742 TDLDTGFNGKLVYAVSGGNED----SCFMIDMETGMLKILSPLDRETTDKYTLNITVYDL 797

Query: 544 --NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS 601
              +  +   + V +++ ND  P     SYF+ +  D +V + I   ++  TD D  P  
Sbjct: 798 GIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEI--IQVEATDKDLGPNG 855

Query: 602 -FRYSIGPGNVNNHFTFSPNAGSNVTRL 628
              YSI    V +  TFS ++ + V  +
Sbjct: 856 HVTYSI----VTDTDTFSIDSVTGVVNI 879



 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 142/626 (22%), Positives = 245/626 (39%), Gaps = 74/626 (11%)

Query: 31  VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90
           ++E +PP T V      +     P       +  S P    F +N+ +G    +     +
Sbjct: 376 ISEFAPPNTPV------VMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQ 429

Query: 91  QLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANP 150
           Q         F+L++   D    T + V  +     + PP+F     +      V     
Sbjct: 430 QAAH------FELEVTTSDRKASTKVLVKVLGAN--SNPPEFTQTAYKAAFDENVPIGTT 481

Query: 151 GFIYQVEAFDPEDTSRN-IPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
             +  + A DP++     +  S   ++          G + ++  LD+E   R + L + 
Sbjct: 482 --VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIR 539

Query: 210 VRDSGGLKASTELQV----NIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDD 265
             D  GL    E++V     + NLND  P F       T+  +L  G  +  ++A D D+
Sbjct: 540 ASD-WGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598

Query: 266 EGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQ 325
                + + +   +  +F +N  +G + + + +    G   +    SL +   D      
Sbjct: 599 LQLVQYQIEAGNELD-FFSLNPNSGVLSLKRSLMDGLGA--KVSFHSLRITATDGENFAT 655

Query: 326 ENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLL---DLNKFCFDDDS-EAPNN 381
              I IT        N   C++   + M+ E+  +   L    ++    FD  S  A   
Sbjct: 656 PLYINITVAASHKLVN-LQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIP 714

Query: 382 RFNFTMPSG--------VGSGSRFLQ----DPAGSGKIVLI----------------GDL 413
           +F  T+P+G        VGS   F+     D   +GK+V                  G L
Sbjct: 715 QFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGML 774

Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473
              +P +    +KYT+ I V D+  P       ++++    N+ P  F + SY  +VSE 
Sbjct: 775 KILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSED 834

Query: 474 RPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532
           +   + + QV ATDKDL P   + YSI T        + F I+  TG + +   +D E  
Sbjct: 835 KEVHSEIIQVEATDKDLGPNGHVTYSIVTD------TDTFSIDSVTGVVNIARPLDRELQ 888

Query: 533 PIYILRIQATNN-----EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQN 587
             + L+I+A +      +  S+V V V++ + ND  P   P +Y + +  DL  GT I  
Sbjct: 889 HEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW 948

Query: 588 FKLTCTDLDSSPRSFRYSI---GPGN 610
            +    DL  S +  RYS+   G GN
Sbjct: 949 LEAHDPDLGQSGQ-VRYSLLDHGEGN 973



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 139/626 (22%), Positives = 258/626 (41%), Gaps = 84/626 (13%)

Query: 31   VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLT------------EAFRVNWLS 78
            +A+N+ P  +  ++SV+LS ++S  I  F  +V ++  +            +AF +N  S
Sbjct: 1659 IADNASPKFTSKEYSVELSETVS--IGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHS 1716

Query: 79   GTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE------PPQF 132
            GT   ++T   + LDFET P I+ L I   +  G++    + V + D N+        ++
Sbjct: 1717 GT---IIT--QKALDFETLP-IYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY 1770

Query: 133  QGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRM---SANGTL 189
             G ++E   +  V   +      + A D +  S N  L Y ++ P         S+ G +
Sbjct: 1771 TGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVEPSVHTYFAIDSSTGAI 1829

Query: 190  FSTTELDFEAGHRSFHLIVEVRDSGGLKASTE----LQVNIVNLNDEVPRFTSPTRVYTV 245
             +   LD+E     FH  V+V D G  +   E    + V+++++ND  P F  P    ++
Sbjct: 1830 HTVLSLDYEETS-IFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASL 1888

Query: 246  LEELSPGTIVANITAEDPDDEGFPSHLLYSIT--TVSKYFMINQLTGTIQVAQRIDRDAG 303
            L     G  V  + A D D   F S L+YSIT   + + F ++  TG + V     ++  
Sbjct: 1889 LLPTYKGVKVITVNATDADSSAF-SQLIYSITEGNIGEKFSMDYKTGALTV-----QNTT 1942

Query: 304  ELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFT---FSIMVPERTAK 360
            +LR      L V   D  + G      +T +  +V ++  +  KFT   +S +V E + +
Sbjct: 1943 QLRSR--YELTVRASDGRFAG------LTSVKINVKESKESHLKFTQDVYSAVVKENSTE 1994

Query: 361  GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN 420
               L  +          A  N  N  +   + +  R  +    SG +   G      P +
Sbjct: 1995 AETLAVIT---------AIGNPINEPLFYHILNPDRRFKISRTSGVLSTTG-----TPFD 2040

Query: 421  LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV 480
                  + V+++V +   P    +V V ++   +N+   +F    Y   V         +
Sbjct: 2041 REQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVI 2100

Query: 481  GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET-TPIYILRI 539
              V A D+D  ++  ++         ++   F I P  GE+ L  + + +T    Y++ +
Sbjct: 2101 RYVTAVDRDSGRNGEVHYYLK-----EHHEHFQIGP-LGEISLKKQFELDTLNKEYLVTV 2154

Query: 540  QATNNEDTS-SVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSS 598
             A +  + + S  V V I   N   P+     Y   +   ++V + + + +       +S
Sbjct: 2155 VAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQA------NS 2208

Query: 599  PRSFR--YSIGPGNVNNHFTFSPNAG 622
            P   +  YSI  G+  + FT + N G
Sbjct: 2209 PEGLKVFYSITDGDPFSQFTINFNTG 2234



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 123/558 (22%), Positives = 226/558 (40%), Gaps = 55/558 (9%)

Query: 89   MEQLDFET-GPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVE 146
            +E+LD ET    +  +++  KD  G      + V +TD N+  PQF+    E   + I  
Sbjct: 2551 LEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYE---VNIGS 2607

Query: 147  RANPGF-IYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN----GTLFSTTELDFEAGH 201
             A  G  + +V A D ++ S N  ++Y + +  +S + +        + +T E      +
Sbjct: 2608 SAAKGTSVVKVLASDADEGS-NADITYAIEADSESVKENLEINKLSGVITTKESLIGLEN 2666

Query: 202  RSFHLIVEVRDSGGLKASTELQVNIVNLNDEV--PRFTSPTRVYTVLEELSPGTIVANIT 259
              F   V   D+G     + + V +  L  E+  P+F+ P   +TV E++  GT +  I 
Sbjct: 2667 EFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIR 2726

Query: 260  AEDPDDEGFPSHLLYSI-------TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTIS 312
            AE          +LYS+       +   + F+I++ +G +++ + +D +  +  Q  +I 
Sbjct: 2727 AEHSGT------VLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQF-SIL 2779

Query: 313  LEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCF 372
                  D         + ++  V+D NDN    +   +   + E    G+ ++ +     
Sbjct: 2780 ARCTQDDHEMVAS---VDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRA--- 2833

Query: 373  DDDSEAPNNRFNFTMPSGVGSGSRFLQDPA---GSGKIVLIGDLDYENPSNLAAGNKYTV 429
             D     N +  +++          ++  A    +G I  + +LD+E   N      Y +
Sbjct: 2834 SDADSGTNGQVMYSLDQS--QSVEVIESFAINMETGWITTLKELDHEKRDN------YQI 2885

Query: 430  IIQVQDVAPPYYKNNVYVYILTSPE-NEFPLIFDRPSYVFDVSERRPARTRVGQVRATDK 488
             +   D       ++  +  +T  + N+ P  F    Y   VSE  P    +  +  TD 
Sbjct: 2886 KVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDA 2945

Query: 489  DLPQSS--LLYSISTGGASLQYPNVFWINPKTGELQLVTK--VDCETTPIYILRIQATNN 544
            D  + +  + Y I TGG  L     F +     E ++  K  +D E    Y+L I AT+ 
Sbjct: 2946 DSEEINRQVTYFI-TGGDPL---GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG 3001

Query: 545  EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRY 604
              +S   V V +L+ ND  P+C    Y   +P D+  G  I     T  D+ S+      
Sbjct: 3002 TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYT 3061

Query: 605  SIGPGNVNNHFTFSPNAG 622
             +G G     F  +P+ G
Sbjct: 3062 LLGSG--AEKFKLNPDTG 3077



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 121/523 (23%), Positives = 223/523 (42%), Gaps = 59/523 (11%)

Query: 204 FHLIVEVRDSG-GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAED 262
           + LIV+  +    ++A T+++V +++ ND  P F+  +   ++ E  +  T +A ++A D
Sbjct: 116 YTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATD 175

Query: 263 PDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRP- 321
             D G      YS    +  F I+  +G I +  R+D       +     +E+L  DR  
Sbjct: 176 A-DIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLD-----YLETKLYEMEILAADRGM 229

Query: 322 --YG--GQENRIQITFIVEDVNDNPATCQKFTFSIMVPER-TAKGTLLLDLNKFCFDDDS 376
             YG  G  +  ++T  +E  N+        T S    +R  A   + +D      D D 
Sbjct: 230 KLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTVD------DCDQ 283

Query: 377 EAPNNRFNFTMPSG-VGSGSRFLQDPAGSG--KIVLIGDLDYENPSNLAAGNKYTVIIQV 433
            A  +  + ++ +G +    R ++   GS   K+  IG +D+++         Y + +Q 
Sbjct: 284 GANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHP-----FGYNLTLQA 338

Query: 434 QDVAPPYYKNNVYVYILTSPE-NEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQ 492
           +D   P   ++V V  +TSP+    P+ F++  Y  ++SE  P  T V  V+A    +P 
Sbjct: 339 KDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA----IPA 394

Query: 493 SSLLYSI--STGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSV 550
            S L  +  ST G +      F +N  TG + ++  V  +    +   ++ T ++  +S 
Sbjct: 395 YSHLRYVFKSTPGKA-----KFSLNYNTGLISILEPVKRQQAAHF--ELEVTTSDRKAST 447

Query: 551 TVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSF-RYSIGPG 609
            V V +L  N   P  T  +Y  A   ++ +GT + +  L+  D D     +  YSI   
Sbjct: 448 KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS--LSAVDPDEGENGYVTYSI--A 503

Query: 610 NVN------NHFTFSPNAGSNVTRLLLTSRFDYA-----GGFDKIWDYKLLVYVTDDNLM 658
           N+N      +HFT + +   N+   L+   +         G     + ++L  +T +NL 
Sbjct: 504 NLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLN 563

Query: 659 SDRKKAEALVETGTVTLSIKVIPHPTTI--ITTTPRPRVTYQV 699
            +    E +   GT+   + V    TT+  I       V YQ+
Sbjct: 564 DNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQI 606



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 49/189 (25%), Positives = 81/189 (42%), Gaps = 17/189 (8%)

Query: 458 PLIFDRPSYVFDVSERRPARTRVGQVRATDKDL--PQSSLLYSISTGGASLQYPNVFWIN 515
           PL F    Y   V E   A+T VG        +  P   + Y I +G +   +    +I 
Sbjct: 31  PLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL 90

Query: 516 PKTGELQLVTK------VDCETTPIYILRIQAT--NNEDTSSVTVTVNILEENDEKPICT 567
                L++ TK      ++ E    Y L ++A   N    +   V V +L+ ND +P+ +
Sbjct: 91  GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFS 150

Query: 568 PNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTR 627
           P SY ++LP +  + T+I     T  D+ ++   F YS    +  + F   P +G     
Sbjct: 151 PTSYSVSLPENTAIRTSIARVSATDADIGTN-GEFYYSF--KDRTDMFAIHPTSGV---- 203

Query: 628 LLLTSRFDY 636
           ++LT R DY
Sbjct: 204 IVLTGRLDY 212


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score =  139 bits (349), Expect = 2e-32
 Identities = 148/549 (26%), Positives = 248/549 (45%), Gaps = 51/549 (9%)

Query: 92   LDFETGPNIFDLQIY-VKDEVGVTDLQVLTVQVT--DVNE-PPQFQGNLAEGLHLYIVER 147
            LD E G  ++ + +Y ++        Q   V++T  D+N+ PP F  ++   L L + E 
Sbjct: 1696 LDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDM---LDLTVEEN 1752

Query: 148  ANPGF-IYQVEAFDPEDTSRNIPLSYFLIS-PPKSFRMSA-NGTLFSTTELDFEAGHRSF 204
               G  I Q+ A D  D   N  ++Y +IS    SFR+   +G L +T  LD E   RS 
Sbjct: 1753 IGDGSKIMQLTAMDA-DEGANALVTYTIISGADDSFRIDPESGDLIATRRLDRE--RRSK 1809

Query: 205  HLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPD 264
            + ++   D G   +   + + + ++ND  P+F+ P   + + E+  PG++VA I A D D
Sbjct: 1810 YSLLVRADDGLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATD-D 1868

Query: 265  DEGFPSHLLYSITTVSK--YFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPY 322
            D G    + Y +    +   F +N +TG   + + +D    E++Q   ++    V+    
Sbjct: 1869 DSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDY---EVQQYYILT----VRAEDG 1921

Query: 323  GGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNR 382
            GGQ   I++ F + DVNDNP      ++S  + E    G+ +L  N     D  +  N++
Sbjct: 1922 GGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFN---VTDADDGINSQ 1978

Query: 383  FNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQD---VAPP 439
              +++ SG   G +F  D   +G + ++  LD E+ S       Y +++QV D   +   
Sbjct: 1979 LTYSIASGDSLG-QFTVDK--NGVLKVLKALDRESQS------FYNLVVQVHDLPQIPAS 2029

Query: 440  YYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL-PQSSLLYS 498
             + +   V I+    N+ P  F  P   + + E  P  T V + +ATD D  P S + Y+
Sbjct: 2030 RFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATDPDSGPNSYIEYT 2088

Query: 499  ISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNED---TSSVTVTVN 555
            +          N F I    GE++L  ++D E    Y L + AT+      +SS  V V 
Sbjct: 2089 LLN-----PLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVM 2143

Query: 556  ILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR-SFRYSIGPGNVNNH 614
            +L+ ND  PI     Y + +  +   GT+I   ++   D D       RY I  GN N  
Sbjct: 2144 VLDINDNNPIFAQALYKVEINENTLTGTDI--IQVFAADGDEGTNGQVRYGIVNGNTNQE 2201

Query: 615  FTFSPNAGS 623
            F      G+
Sbjct: 2202 FRIDSVTGA 2210



 Score =  137 bits (345), Expect = 4e-32
 Identities = 163/623 (26%), Positives = 265/623 (42%), Gaps = 67/623 (10%)

Query: 30   NVAENSPPGTSV-----HKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEV 84
            ++ EN P GTSV     H     ++  LS  I      +   P    F ++ + GT +  
Sbjct: 1428 SIVENIPIGTSVISVTAHDPDADINGQLSYTI------IQQMPRGNHFTIDEVKGTIYTN 1481

Query: 85   VTTGMEQLDFETGPNIFDLQIYVKDEVGVTD-----LQVLTVQVTDVNEP-PQF--QGNL 136
                  ++D E   N+F+L +   D+    +     L+ +T+ VTD+N+  P F  Q  L
Sbjct: 1482 A-----EIDREFA-NLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNAL 1535

Query: 137  AEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS-PPKSFRMSA-NGTLFSTTE 194
            A      I        +  + A DP D   N  + Y +I+    +F +   +G L   + 
Sbjct: 1536 AADPSAVI-----GSVLTTIMAADP-DEGANGEIEYEIINGDTDTFIVDRYSGDLRVASA 1589

Query: 195  LDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSP-GT 253
            L        ++LIV   D G  +  +  ++ I+    + P FT P +  T+L+E  P GT
Sbjct: 1590 L--VPSQLIYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQP-KYITILKEGEPIGT 1646

Query: 254  IVANITAEDPDDEGFP-SHLLYSI----TTVSKYFMINQLTGTIQVAQRIDRDAGELRQN 308
             V +I A  P     P  + + S+     TV + F I + TG IQ A  +DR+ G     
Sbjct: 1647 NVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLY- 1705

Query: 309  PTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLN 368
              + +  + K   +  +  R ++   ++D+NDNP         + V E    G+ ++ L 
Sbjct: 1706 -LVDVYAIEKSTAF-PRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLT 1763

Query: 369  KFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYT 428
                 D  E  N    +T+ SG     R   DP  SG ++    LD E  S      KY+
Sbjct: 1764 AM---DADEGANALVTYTIISGADDSFRI--DPE-SGDLIATRRLDRERRS------KYS 1811

Query: 429  VIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDK 488
            ++++  D       +++ + I  S  N+    F RP Y FD+ E     + V  + ATD 
Sbjct: 1812 LLVRADD---GLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDD 1868

Query: 489  DL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN-NED 546
            D      + Y ++          +F++NP TG   L   +D E    YIL ++A +    
Sbjct: 1869 DSGVNGEITYIVNEDDED----GIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQ 1924

Query: 547  TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSI 606
             +++ V  NIL+ ND  PI + NSY  +L  +L VG+ +  F +T  D D       YSI
Sbjct: 1925 FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDAD-DGINSQLTYSI 1983

Query: 607  GPGNVNNHFTFSPNAGSNVTRLL 629
              G+    FT   N    V + L
Sbjct: 1984 ASGDSLGQFTVDKNGVLKVLKAL 2006



 Score =  129 bits (324), Expect = 1e-29
 Identities = 152/617 (24%), Positives = 255/617 (41%), Gaps = 50/617 (8%)

Query: 69   TEAFRVNWLSGTYFEVVTTGMEQLDFETGPNI----FDLQIYVKDEVGVTDLQVLTVQVT 124
            +E FR+N  +G  F       + +   +  NI    F +    + +  +     +T+ + 
Sbjct: 2915 SEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIV 2974

Query: 125  DVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLISPPK--S 180
            D N+  PQF   L       + +    G  + +V A D +D   N  + YF+ +      
Sbjct: 2975 DSNDNAPQF---LKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGK 3031

Query: 181  FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDEVPRFTS 238
            F++  +    S         +++F + V  +D G   L +   + + +   N   P F+ 
Sbjct: 3032 FKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQ 3091

Query: 239  PTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSK--YFMINQLTGTIQVAQ 296
                 T+ E  S G+IV  ++A D D       + YSI++ ++   F IN  TG + +A+
Sbjct: 3092 SHMSATIPESHSIGSIVRTVSARDRD-AAMNGLIKYSISSGNEEGIFAINSSTGILTLAK 3150

Query: 297  RIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPE 356
             +D    EL Q   +++  +  D  +  +     +T  V DVNDN        +   V E
Sbjct: 3151 ALDY---ELCQKHEMTISAI--DGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLE 3205

Query: 357  RTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYE 416
                GT ++ LN     D     N    +T+ S       F+ DP  +G I   G LD+E
Sbjct: 3206 NAPSGTTVIHLNA---TDADSGTNAVIAYTVQSS--DSDLFVIDP-NTGVITTQGFLDFE 3259

Query: 417  NPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPA 476
               +      Y + ++  +V      +   V I     NE+   F    Y F++SE  P 
Sbjct: 3260 TKQS------YHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPK 3313

Query: 477  RTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYI 536
             T VG+V A+D+DL     ++ +  G +  +    F IN KTG++ +   +D E      
Sbjct: 3314 GTIVGEVFASDRDLGTDGEVHYLIFGNSRKKG---FQINKKTGQIYVSGILDREKEERVS 3370

Query: 537  LRIQATN-----NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLT 591
            L++ A N       D   VTV V +L+ ND  PI T N Y + +   + +GT++      
Sbjct: 3371 LKVLAKNFGSIRGADIDEVTVNVTVLDANDP-PIFTLNIYSVQISEGVPIGTHVTFVSAF 3429

Query: 592  CTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVY 651
             +D   S   F Y IG GN N  F+ +P  G    ++ +T+  D     + +  Y L V 
Sbjct: 3430 DSDSIPSWSRFSYFIGSGNENGAFSINPQTG----QITVTAELDR----ETLPIYNLSVL 3481

Query: 652  VTDDNLMSDRKKAEALV 668
              D    S    A  LV
Sbjct: 3482 AVDSGTPSATGSASLLV 3498



 Score =  119 bits (297), Expect = 2e-26
 Identities = 147/602 (24%), Positives = 249/602 (41%), Gaps = 49/602 (8%)

Query: 48   LSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYV 107
            +SAS   +      ++ +      F +N ++G          E+  F      + L++  
Sbjct: 815  VSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSF------YQLKVVA 868

Query: 108  KDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSR 166
                 VT   ++ + V D+N+         E ++  +VE    G  I+Q +A DP++   
Sbjct: 869  SGGT-VTGDTMVNITVKDLNDNSPHFLQAIESVN--VVENWQAGHSIFQAKAVDPDEGVN 925

Query: 167  NIPLSYFLISPPKSFRMSA-NGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVN 225
             + L     +P   F ++  NGT+     LD  AG     ++        L +S  L V 
Sbjct: 926  GMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHAGSYQIEILASDMGVPQLSSSVILTVY 985

Query: 226  IVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSIT--TVSKYF 283
            + ++ND  P F   +   T+ E     +    + A D D  G    + Y+I        F
Sbjct: 986  VHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDS-GANGEIAYTIAEGNTGDAF 1044

Query: 284  MINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPA 343
             I    G + +   +DR+  +        L V+  DR        + +T I+EDVNDN  
Sbjct: 1045 GIFP-DGQLYIKSELDRELQD-----RYVLMVVASDRAVEPLSATVNVTVILEDVNDNRP 1098

Query: 344  TCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNN--RFNFTMPSGVGSGSRFLQDP 401
                  ++    E    G+ +    K    D    PN   R++F M           +  
Sbjct: 1099 LFNSTNYTFYFEEEQRAGSFV---GKVSAVDKDFGPNGEVRYSFEMVQPD------FELH 1149

Query: 402  AGSGKIVLIGDLDYENPSNL--AAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPL 459
            A SG+I      D E+       A   +TVI   Q +  P  K+   V++     N+   
Sbjct: 1150 AISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPL-KDQATVHVYMKDINDNAP 1208

Query: 460  IFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKT 518
             F +  Y   +SE     T+V +V A+D D   + L+ YSI  G    Q    F I+  +
Sbjct: 1209 KFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQ----FAIDSTS 1264

Query: 519  GELQLVTKVDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLAL 575
            G++ L+ K+D E TP Y L IQA ++      S+ T+ ++IL+END  P    ++ F+ +
Sbjct: 1265 GQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDV 1324

Query: 576  PVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRF 634
              ++++G  + +  +T TD DS   +   YSI   N +  F+ SPN GS    + L  + 
Sbjct: 1325 LENMRIGELVSS--VTATDSDSGDNADLYYSITGTNNHGTFSISPNTGS----IFLAKKL 1378

Query: 635  DY 636
            D+
Sbjct: 1379 DF 1380



 Score =  112 bits (281), Expect = 1e-24
 Identities = 152/611 (24%), Positives = 251/611 (41%), Gaps = 64/611 (10%)

Query: 79  GTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT--DVNEPPQFQGNL 136
           G +  +V+ G   LD E  P  + L + V+D+        L V VT  D+N+ P   G+ 
Sbjct: 197 GAFLHLVSKG--GLDREVTPQ-YQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGS- 252

Query: 137 AEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTE- 194
                  + E A  G  + QV A D  D   N  + Y L      F+M     L +  E 
Sbjct: 253 -SHYQAGVPEDAVVGSSVLQVAAADA-DEGTNADIRYRLQDEGTPFQMDPETGLITVREP 310

Query: 195 LDFEAGHRSFHLIVEVRDSG--GLKASTELQVNIVNLNDEVP-----RFTSPTRVYTVLE 247
           LDFEA  R + L V+  D G   L    E  + ++++ND  P      F + +R  +V E
Sbjct: 311 LDFEA-RRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDE 369

Query: 248 ELSPGTIVANITAEDPDDEGFPSHLLYSIT--TVSKYFMINQLT----GTIQVAQRIDRD 301
               GT+VA +T  D D      ++   I      ++F +          I+VA  +DR+
Sbjct: 370 NAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRE 429

Query: 302 AGELRQNPTISLEVLVKDRPYGG--------QENRIQITFIVEDVNDNPATCQKFTFSIM 353
                + P+ +L V V D  YG         + +   +   V D+ND+P    +  + + 
Sbjct: 430 -----RIPSYNLTVSVSDN-YGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVN 483

Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413
           + E    G+ +  ++     D     N    +++ SG G G   + + +G       G L
Sbjct: 484 LSEEAPPGSYVSGISA---TDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGL 540

Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473
           D E  S +       +  + Q V P      + V +L    +E P+      Y   V E 
Sbjct: 541 DRELASQIVLN----ISARDQGVHPKVSYAQLVVTLL-DVNDEKPVFSQPEGYDVSVVEN 595

Query: 474 RPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532
            P  T +  +RATD DL  +  + +S+       +    F ++P +G L  ++ +D E  
Sbjct: 596 APTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRS---FRLDPVSGRLSTISSLDREEQ 652

Query: 533 PIYILRIQATN---NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK 589
             Y L + AT+      +S   + V++L+ ND  P+  P  YF  +  +   G+ I    
Sbjct: 653 AFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVS 712

Query: 590 LTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLL 649
            T  DL ++  + +YSI  G+  + F  +  +G   TR+ L      A        Y+L 
Sbjct: 713 ATDPDLGTN-GTVKYSISAGD-RSRFQVNAQSGVISTRMALDREEKTA--------YQLQ 762

Query: 650 VYVTD-DNLMS 659
           +  TD  NL S
Sbjct: 763 IVATDGGNLQS 773



 Score =  112 bits (280), Expect = 2e-24
 Identities = 157/624 (25%), Positives = 259/624 (41%), Gaps = 78/624 (12%)

Query: 62   IVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGV--TDLQVL 119
            IVN N   E FR++ ++G       T  + LD E  P  + L +   D      TD   +
Sbjct: 2193 IVNGNTNQE-FRIDSVTGAI-----TVAKPLDREKTPT-YHLTVQATDRGSTPRTDTSTV 2245

Query: 120  TVQVTDVN------EPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYF 173
            ++ + D+N      E   +  N+ E L         P  I QV A D +D   N  LSY 
Sbjct: 2246 SIVLLDINDFVPVFELSPYSVNVPENLGTL------PRTILQVVARD-DDRGSNSKLSYV 2298

Query: 174  LI--SPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNL 229
            L   +   +F +SA+G L  T  LD E   R F L++   DSG   L  +  + V + ++
Sbjct: 2299 LFGGNEDNAFTLSASGELGVTQSLDRETKER-FVLMITATDSGSPALTGTGTINVIVDDV 2357

Query: 230  NDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLT 289
            ND VP F S     T+ E+   GT V  + A D D      + +  I   +  F IN  T
Sbjct: 2358 NDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADAS---KNAVIRIIGGNSQFTINPST 2414

Query: 290  GTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQE---NRIQITFIVEDVNDNPATCQ 346
            G I  +  +DR   E + N T  L V+  D   G  E   +   +   V DVNDNP   Q
Sbjct: 2415 GQIITSALLDR---ETKDNYT--LVVVCSDA--GSPEPLSSSTSVLVTVTDVNDNPPRFQ 2467

Query: 347  KFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGK 406
               +   +P  T  G+ +  +      D    PN+  ++++ SG  S  +F  DP   G 
Sbjct: 2468 HHPYVTHIPSPTLPGSFVFAVT---VTDADIGPNSELHYSL-SGRNS-EKFHIDPL-RGA 2521

Query: 407  IVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSY 466
            I+  G L+          ++ T  + V+D       ++  V +    + +FP +  +   
Sbjct: 2522 IMAAGPLN--------GASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAK-EQ 2572

Query: 467  VFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTK 526
             F   E +P  + V  +  T   L    + Y I++G       N F I+  TG++ +   
Sbjct: 2573 TFMFPENQPVSSLVTTI--TGSSLRGEPMSYYIASGNLG----NTFQIDQLTGQVSISQP 2626

Query: 527  VDCETTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGT 583
            +D E    Y++ I+A +      +S   + + +L+ ND  PI   + +   +  +L   +
Sbjct: 2627 LDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENL---S 2683

Query: 584  NIQNFKLTCTDLDSSPR-SFRYSIGPGNVNNHFTFSPNAG----------SNVTRLLLTS 632
              +   ++  D DS P     Y I  GN+ N F+ +   G            V+  +LT 
Sbjct: 2684 PRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTI 2743

Query: 633  RFDYAGGFDKIWDYKLLVYVTDDN 656
            +    G   +    K+++ + D+N
Sbjct: 2744 KSSDKGSPSQSTSVKVMINILDEN 2767



 Score =  111 bits (277), Expect = 3e-24
 Identities = 172/668 (25%), Positives = 280/668 (41%), Gaps = 88/668 (13%)

Query: 31   VAENSPPGTSVHKFSVK-LSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGM 89
            + E++P GT V   +     AS + VI    +I+  N     F +N  +G   +++T+ +
Sbjct: 2373 IPEDAPTGTDVLLVNASDADASKNAVI----RIIGGN---SQFTINPSTG---QIITSAL 2422

Query: 90   EQLDFETGPNIFDLQIYVKDEVGVTDLQVLT---VQVTDVNE-PPQFQGNLAEGLHLYIV 145
              LD ET  N + L +   D      L   T   V VTDVN+ PP+FQ       H Y+ 
Sbjct: 2423 --LDRETKDN-YTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQH------HPYVT 2473

Query: 146  ERANP----GFIYQVEAFDPEDTSRNIPLSY---------FLISPPKSFRMSANGTLFST 192
               +P     F++ V   D  D   N  L Y         F I P +   M+A G L   
Sbjct: 2474 HIPSPTLPGSFVFAVTVTDA-DIGPNSELHYSLSGRNSEKFHIDPLRGAIMAA-GPLNGA 2531

Query: 193  TELDFEAGHRSFHLIVEVRDSGGLKA--STELQVNIVNLNDEVPRFTSPTRVYTVLEELS 250
            +E+ F          V V+D G      ST + V  VN  D  P+  +  + +   E   
Sbjct: 2532 SEVTFS---------VHVKDGGSFPKTDSTTVTVRFVNKAD-FPKVRAKEQTFMFPENQP 2581

Query: 251  PGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPT 310
              ++V  IT       G P     +   +   F I+QLTG + ++Q +D    E  Q   
Sbjct: 2582 VSSLVTTITGSSL--RGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDF---EKIQKYV 2636

Query: 311  ISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKF 370
            + +E      P      ++ IT +  DVNDN    ++  F   + E  +   +L      
Sbjct: 2637 VWIEARDGGFPPFSSYEKLDITVL--DVNDNAPIFKEDPFISEILENLSPRKIL---TVS 2691

Query: 371  CFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVI 430
              D DS  PN + ++ + +G    S  +     +G+I  +  LD E  S+      Y + 
Sbjct: 2692 AMDKDS-GPNGQLDYEIVNGNMENSFSINH--ATGEIRSVRPLDREKVSH------YVLT 2742

Query: 431  IQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL 490
            I+  D   P    +V V I    EN+    F +  +   V E  P    V +V  +D+D+
Sbjct: 2743 IKSSDKGSPSQSTSVKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDI 2801

Query: 491  PQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSS 549
              +++  YSI    ASL     F INP TG++ +   ++ E T  Y +R+ A ++  T S
Sbjct: 2802 GINAISRYSIMD--ASLP----FTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVS 2855

Query: 550  VTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPG 609
              VT+ + + ND  P  +  SY+L  P   ++G+ +     T  D  S+ + F +     
Sbjct: 2856 TDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFI---K 2912

Query: 610  NVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE 669
            + + +F  +   G    + +L  ++    GF  +   +    VT     SDR K   + E
Sbjct: 2913 SQSEYFRINATTGEIFNKQIL--KYQNVTGFSNVNINRHSFIVTS----SDRGKPSLISE 2966

Query: 670  TGTVTLSI 677
            T TVT++I
Sbjct: 2967 T-TVTINI 2973



 Score =  105 bits (262), Expect = 2e-22
 Identities = 122/505 (24%), Positives = 218/505 (43%), Gaps = 59/505 (11%)

Query: 119  LTVQVTDVNE------PPQFQGNLAEGLHLYIVERANPG--FIYQVEAFDPEDTSRNIPL 170
            + V + D+N+      P Q+  ++ E           PG  +I  V A DP D   N  +
Sbjct: 675  INVSLLDINDNSPVFYPVQYFAHIKEN---------EPGGSYITTVSATDP-DLGTNGTV 724

Query: 171  SYFLISPPKS-FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTE--LQVNIV 227
             Y + +  +S F+++A   + ST          ++ L +   D G L++  +  + + ++
Sbjct: 725  KYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVL 784

Query: 228  NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSK--YFMI 285
            +  D  P F+     + V E ++ G  V +++A   D     S++ Y ITT  +   F I
Sbjct: 785  DTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMD---LNSNISYLITTGDQKGMFAI 841

Query: 286  NQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATC 345
            NQ+TG +  A  IDR+     Q     L+V+       G +  + IT  V+D+NDN    
Sbjct: 842  NQVTGQLTTANVIDREEQSFYQ-----LKVVASGGTVTG-DTMVNIT--VKDLNDNSPHF 893

Query: 346  QKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSG 405
             +   S+ V E    G  +         D  E  N    +++     +          +G
Sbjct: 894  LQAIESVNVVENWQAGHSIFQAKAV---DPDEGVNGMVLYSLKQ---NPKNLFAINEKNG 947

Query: 406  KIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPS 465
             I L+G LD    S       Y + I   D+  P   ++V + +     N+   +FD+ S
Sbjct: 948  TISLLGPLDVHAGS-------YQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLS 1000

Query: 466  YVFDVSERRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLV 524
            Y   +SE  P  +R  +V+A+DKD      + Y+I+ G       + F I P  G+L + 
Sbjct: 1001 YEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTG----DAFGIFP-DGQLYIK 1055

Query: 525  TKVDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKV 581
            +++D E    Y+L + A++      +++V VTV + + ND +P+    +Y      + + 
Sbjct: 1056 SELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRA 1115

Query: 582  GTNIQNFKLTCTDLDSSPR-SFRYS 605
            G+ +   K++  D D  P    RYS
Sbjct: 1116 GSFVG--KVSAVDKDFGPNGEVRYS 1138



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 122/533 (22%), Positives = 231/533 (43%), Gaps = 49/533 (9%)

Query: 72   FRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDE---VGVTDLQVLTVQVTDVNE 128
            F ++ +SG          E L    G  +F   +   D+     + D   + V + D+N+
Sbjct: 1146 FELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDIND 1205

Query: 129  -PPQFQGNLAEGLHLYIVERA-NPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN 186
              P+F   L +     I E A N   + +V A D ++ +  + + Y +I   +  + + +
Sbjct: 1206 NAPKF---LKDFYQATISESAANLTQVLRVSASDVDEGNNGL-IHYSIIKGNEERQFAID 1261

Query: 187  GTLFSTT---ELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDEVPRFTSPTR 241
             T    T   +LD+EA   ++ L+++  DSG   L ++  L ++I++ ND  P F   T 
Sbjct: 1262 STSGQVTLIGKLDYEATP-AYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTL 1320

Query: 242  VYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FMINQLTGTIQVAQRID 299
               VLE +  G +V+++TA D  D G  + L YSIT  + +  F I+  TG+I +A+++D
Sbjct: 1321 FVDVLENMRIGELVSSVTATD-SDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLD 1379

Query: 300  RDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTA 359
             +   L       L +  KD+    + + + +   V D NDNP +         + E   
Sbjct: 1380 FETQSL-----YKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIP 1434

Query: 360  KGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPS 419
             GT ++ +     D D++  N + ++T+   +  G+ F  D    G I    ++D E   
Sbjct: 1435 IGTSVISVT--AHDPDADI-NGQLSYTIIQQMPRGNHFTIDEV-KGTIYTNAEIDRE--- 1487

Query: 420  NLAAGNKYTVIIQVQDVAPP-----YYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERR 474
                 N + + ++  D A P     Y   NV + ++T   +  P+   + +   D S   
Sbjct: 1488 ---FANLFELTVKANDQAVPIETRRYALKNVTI-LVTDLNDNVPMFISQNALAADPS--A 1541

Query: 475  PARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTP 533
               + +  + A D D      + Y I  G       + F ++  +G+L++ + +   +  
Sbjct: 1542 VIGSVLTTIMAADPDEGANGEIEYEIINGDT-----DTFIVDRYSGDLRVASAL-VPSQL 1595

Query: 534  IYILRIQATN-NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI 585
            IY L + AT+   +    T  + I+ +  + P+ T   Y   L     +GTN+
Sbjct: 1596 IYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNV 1648



 Score = 94.0 bits (232), Expect = 6e-19
 Identities = 122/483 (25%), Positives = 201/483 (41%), Gaps = 43/483 (8%)

Query: 119  LTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176
            +T+ VTD+N+  P+F        +L   E    G  + QV A DP++ S N  + YF+ S
Sbjct: 2858 VTIFVTDINDNAPRFSRT---SYYLDCPELTEIGSKVTQVFATDPDEGS-NGQVFYFIKS 2913

Query: 177  PPKSFRMSAN-GTLFSTTELDFE---------AGHRSFHLIVEVRDSGGLKASTELQVNI 226
              + FR++A  G +F+   L ++             SF +    R    L + T + +NI
Sbjct: 2914 QSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINI 2973

Query: 227  VNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FM 284
            V+ ND  P+F        V + +  GT +  +TA D  D G  S + Y I+  +    F 
Sbjct: 2974 VDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFK 3033

Query: 285  INQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPAT 344
            ++  TG I VA  +  D   L QN  I++    K  P    +  + IT + E+    P  
Sbjct: 3034 LDNDTGWISVASSLISD---LNQNFFITVTAKDKGNPPLSSQATVHIT-VTEENYHTPEF 3089

Query: 345  CQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGS 404
             Q    S  +PE  + G+++  ++     D   A N    +++ SG   G   +   + +
Sbjct: 3090 SQSH-MSATIPESHSIGSIVRTVSA---RDRDAAMNGLIKYSISSGNEEGIFAIN--SST 3143

Query: 405  GKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP 464
            G + L   LDYE         K+ + I   D           V +     N+   +F   
Sbjct: 3144 GILTLAKALDYE------LCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSD 3197

Query: 465  SYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQL 523
             Y   V E  P+ T V  + ATD D   ++++ Y++ +  + L     F I+P TG +  
Sbjct: 3198 DYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDL-----FVIDPNTGVITT 3252

Query: 524  VTKVDCETTPIYILRIQATN---NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLK 580
               +D ET   Y L ++A N    E  S  TV + +   N+  P      Y+  +     
Sbjct: 3253 QGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAP 3312

Query: 581  VGT 583
             GT
Sbjct: 3313 KGT 3315



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 105/433 (24%), Positives = 177/433 (40%), Gaps = 50/433 (11%)

Query: 239 PTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRI 298
           P +V+ VLEE  PGT+V  I        GF     Y ++     F IN  TG +     I
Sbjct: 45  PRQVFQVLEEQPPGTLVGTIQTR----PGF----TYRLSESHALFAINSSTGALYTTSTI 96

Query: 299 DRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERT 358
           DR   E   +  I+L VL     Y       ++  +V D+NDN       +  +   E +
Sbjct: 97  DR---ESLPSDVINLVVLSSAPTY-----PTEVRVLVRDLNDNAPVFPDPSIVVTFKEDS 148

Query: 359 AKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQD----PAGSG---KIVLIG 411
           + G  ++       D  S   ++R ++ +  G  +G RF  D    P+G G    +V  G
Sbjct: 149 SSGRQVILDTATDSDIGSNGVDHR-SYRIIRGNEAG-RFRLDITLNPSGEGAFLHLVSKG 206

Query: 412 DLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVS 471
            LD E         +Y ++++V+D   P  +  + V +     N+ P +F    Y   V 
Sbjct: 207 GLDRE------VTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVP 260

Query: 472 ERRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCE 530
           E     + V QV A D D    + + Y +   G   Q      ++P+TG + +   +D E
Sbjct: 261 EDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQ------MDPETGLITVREPLDFE 314

Query: 531 TTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPIC-----TPNSYFLALPVDLKVG 582
               Y L +QA +      T      + +L+ ND  P+         S + ++  + +VG
Sbjct: 315 ARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVG 374

Query: 583 TNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDK 642
           T +    +T  D  ++  +    I  GN   HF    +   N++ + + S  D     ++
Sbjct: 375 TVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDR----ER 430

Query: 643 IWDYKLLVYVTDD 655
           I  Y L V V+D+
Sbjct: 431 IPSYNLTVSVSDN 443



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 110/465 (23%), Positives = 187/465 (40%), Gaps = 45/465 (9%)

Query: 184 SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVY 243
           S+ G L++T+ +D E+       +V +  S      TE++V + +LND  P F  P+ V 
Sbjct: 85  SSTGALYTTSTIDRESLPSDVINLVVL--SSAPTYPTEVRVLVRDLNDNAPVFPDPSIVV 142

Query: 244 TVLEELSPGTIVANITAEDPD-DEGFPSHLLYSITTVSK--YFMIN---QLTGTIQVAQR 297
           T  E+ S G  V   TA D D       H  Y I   ++   F ++     +G       
Sbjct: 143 TFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHL 202

Query: 298 IDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPER 357
           + +   +    P   L V V+D+    +   +Q+   V+D+NDNP       +   VPE 
Sbjct: 203 VSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPED 262

Query: 358 TAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYEN 417
              G+ +L +      D  E  N    + +      G+ F  DP  +G I +   LD+E 
Sbjct: 263 AVVGSSVLQV---AAADADEGTNADIRYRLQD---EGTPFQMDPE-TGLITVREPLDFE- 314

Query: 418 PSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYI-LTSPENEFPLI----FDRPSYVFDVSE 472
                A  +Y++ +Q  D   P         I L    +  P++    F   S    V E
Sbjct: 315 -----ARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDE 369

Query: 473 RRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWIN----PKTGELQLVTKVD 528
                T V  +  TD D P ++   S+   G + Q    F +     P    +++ + +D
Sbjct: 370 NAQVGTVVALLTVTDADSPAANGNISVQILGGNEQ--RHFEVQSSKVPNLSLIKVASALD 427

Query: 529 CETTPIYILRIQATNN----------EDTSSVTVTVNILEENDEKPICTPNSYFLALPVD 578
            E  P Y L +  ++N            +S  ++ + + + ND  P+ +   Y + L  +
Sbjct: 428 RERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEE 487

Query: 579 LKVGTNIQNFKLTCTDLDSS-PRSFRYSIGPGNVNNHFTFSPNAG 622
              G+ +    ++ TD DS    + RYSI  GN    F  S ++G
Sbjct: 488 APPGSYVSG--ISATDGDSGLNANLRYSIVSGNGLGWFHISEHSG 530



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 89/308 (28%), Positives = 137/308 (44%), Gaps = 37/308 (12%)

Query: 62   IVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKD--EVGVTDLQVL 119
            ++  N   + F++N  +G   ++  +G+  LD E    +  L++  K+   +   D+  +
Sbjct: 3336 LIFGNSRKKGFQINKKTG---QIYVSGI--LDREKEERV-SLKVLAKNFGSIRGADIDEV 3389

Query: 120  TVQVT--DVNEPPQFQGNLAEGLHLYIVERANPG-FIYQVEAFDPEDTSRNIPLSYFLIS 176
            TV VT  D N+PP F  N+     + I E    G  +  V AFD +        SYF+ S
Sbjct: 3390 TVNVTVLDANDPPIFTLNIYS---VQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGS 3446

Query: 177  PPKSFRMSAN---GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKA--STELQVNIVNLND 231
              ++   S N   G +  T ELD E     ++L V   DSG   A  S  L V + ++ND
Sbjct: 3447 GNENGAFSINPQTGQITVTAELDRET-LPIYNLSVLAVDSGTPSATGSASLLVTLEDIND 3505

Query: 232  EVPRFTSPTRVYTVLEELSPGTIVANITAEDPD---DEGFPSHLLYSITTVSKYFMINQL 288
              P  T       V+E   PGT+V  + + DPD   ++G  ++ L S    + YF ++  
Sbjct: 3506 NGPMLTVSEG--EVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLS-T 3562

Query: 289  TGTIQVAQRIDRDAGELRQNPTISLEVLVKDR--PYGGQENRIQITFIVEDVNDNPATCQ 346
             G +   + IDR+     Q     L V+ KD   P       + IT I  D NDNP+  Q
Sbjct: 3563 AGVLSTTREIDRE-----QIADFYLSVVTKDSGVPQMSSTGTVHITVI--DQNDNPS--Q 3613

Query: 347  KFTFSIMV 354
              T  I V
Sbjct: 3614 SRTVEIFV 3621



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 65/242 (26%), Positives = 111/242 (45%), Gaps = 20/242 (8%)

Query: 31   VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90
            ++E  P GT V   S   S S+ P    F   + S     AF +N  +G   ++  T   
Sbjct: 3413 ISEGVPIGTHVTFVSAFDSDSI-PSWSRFSYFIGSGNENGAFSINPQTG---QITVTA-- 3466

Query: 91   QLDFETGPNIFDLQIYVKDE--VGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERA 148
            +LD ET P I++L +   D      T    L V + D+N+       ++EG    ++E  
Sbjct: 3467 ELDRETLP-IYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPML-TVSEG---EVMENK 3521

Query: 149  NPG-FIYQVEAFDPEDTSRNIPLSYFLIS--PPKS-FRMSANGTLFSTTELDFEAGHRSF 204
             PG  +  +++ DP+      P +Y+L+S  P  S F +S  G L +T E+D E     F
Sbjct: 3522 RPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQ-IADF 3580

Query: 205  HLIVEVRDSG--GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAED 262
            +L V  +DSG   + ++  + + +++ ND   +  +          L PG I+ ++  +D
Sbjct: 3581 YLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQD 3640

Query: 263  PD 264
            PD
Sbjct: 3641 PD 3642


>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
          Length = 3354

 Score =  130 bits (328), Expect = 4e-30
 Identities = 163/617 (26%), Positives = 258/617 (41%), Gaps = 61/617 (9%)

Query: 23  ILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYF 82
           I LP + N+ E+SPPGT+V   +        P   G    + S      F ++++SG   
Sbjct: 237 INLPYSTNIYEHSPPGTTVRIITAIDQDKGRP--RGIGYTIVSGNTNSIFALDYISGVLT 294

Query: 83  EVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT---VQVTDVNE-PPQFQGNLAE 138
                  E   +  G  +      + D+   +D  V T   + V D+N+  P+F    + 
Sbjct: 295 LNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFN---SS 351

Query: 139 GLHLYIVERANPGFIYQVEAFDPEDTSRNIPL------------SYFLISPPKSFRMSAN 186
              + I E A  GF   +      D   N+ L            S+  I  P S +  A+
Sbjct: 352 EYSVAITELAQVGFALPL-FIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKAD 410

Query: 187 GTLFSTTELDFEAGHR-SFHLIV--EVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVY 243
             +     LD+E   R  F L     V D  G     ++++ ++N ND  P F+ P    
Sbjct: 411 IRIRVAIPLDYETVDRYDFDLFANESVPDHVGY---AKVKITLINENDNRPIFSQPLYNI 467

Query: 244 TVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAG 303
           ++ E ++ GT V  + A D +D G    + Y  +     F +++ TG I +  R+D    
Sbjct: 468 SLYENVTVGTSVLTVLATD-NDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDY--- 523

Query: 304 ELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTL 363
           EL Q  T+++      R  GG+E   ++   V DVNDN  T QK  +   + E     T 
Sbjct: 524 ELIQRFTLTIIA----RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ 579

Query: 364 LLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRF-LQDPAGSGKIVLIGDLDYENPSNLA 422
           L+ L      D+   PNN+  +++ S    GS F +    G G I +   LDYE  SN  
Sbjct: 580 LVRLRA---TDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISN-- 634

Query: 423 AGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQ 482
            G  Y + +   D   P   + V V I    EN+ P  F +P+Y   V E   A   V  
Sbjct: 635 -GLIY-LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLF 692

Query: 483 VRATD----KDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILR 538
           + ATD    ++  Q S++Y       SL+    F IN ++GE+   + +D ET   YIL 
Sbjct: 693 LNATDLDRSREYGQESIIY-------SLEGSTQFRINARSGEITTTSLLDRETKSEYILI 745

Query: 539 IQAT-----NNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCT 593
           ++A      +N+ T   TV + +L+ ND  P      Y++ L       +++        
Sbjct: 746 VRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP 805

Query: 594 DLDSSPRSFRYSIGPGN 610
           DL  +  +  YSI P N
Sbjct: 806 DLGEN-GTLVYSIQPPN 821



 Score =  125 bits (315), Expect = 1e-28
 Identities = 162/630 (25%), Positives = 262/630 (41%), Gaps = 64/630 (10%)

Query: 28   TGNVAENSPPGTSVHKFSV---KLSASLSPVIPGFPQIVNSNPLT----EAFRVNWLSGT 80
            T +V E++ PGT +   +     L+  L   I G     +++ L     +AF VN  +G+
Sbjct: 2180 TVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239

Query: 81   YFEVVTTGMEQL-DFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAE 138
                     E +  +E   ++ D    + +         LTV V DVN+  PQF+     
Sbjct: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFK---PF 2296

Query: 139  GLHLY---IVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS--PPKSFRM--SANGTLF 190
            G+  Y   I+E A PG  +  V A DP D   N  ++Y L+   PP   ++  S+ G + 
Sbjct: 2297 GITYYMERILEGATPGTTLIAVAAVDP-DKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVI 2355

Query: 191  STTELDFEAGHRSFHLIVEVRDSGGLKASTELQV--NIVNLNDEVPRFTSPTRVYTVLEE 248
            +   +D+E  H   +  V   D+G    + E+ V   IV++ND  P F  P+    V E+
Sbjct: 2356 ANRTVDYEEVHW-LNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFED 2414

Query: 249  LSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQN 308
            +  GTI+  +TA D D   F + + YS+      F IN  TG I V   +DR+     + 
Sbjct: 2415 VPVGTIILTVTATDADSGNF-ALIEYSLGDGESKFAINPTTGDIYVLSSLDRE-----KK 2468

Query: 309  PTISLEVLVKDRP----YGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLL 364
                L  L KD P       +EN +Q+   V DVND      K  FS  V E    GT +
Sbjct: 2469 DHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSV 2528

Query: 365  LDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAG 424
            + +      D  E PN    +++    G G         SG +        + P  L + 
Sbjct: 2529 ITMMA---TDQDEGPNGELTYSLE---GPGVEAFHVDMDSGLVTT------QRP--LQSY 2574

Query: 425  NKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP--SYVFDVSERRPARTRVGQ 482
             K+++ +   D   P       + +     N+   +F RP    +  + E  P R+ V +
Sbjct: 2575 EKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE 2634

Query: 483  VRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA 541
            V ATDKD     ++ YS      +  +   F I+P +G +Q   ++D E+  +Y L + A
Sbjct: 2635 VYATDKDEGLNGAVRYSFLKTAGNRDW-EFFIIDPISGLIQTAQRLDRESQAVYSLILVA 2693

Query: 542  TN------NEDTSSVTVTVNILEEND----EKPICTPNSYFLALPVDLKVGTNIQNFKLT 591
            ++       E    + V +  +++N+      P  +P    L +P     GT + N    
Sbjct: 2694 SDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNV-TG 2752

Query: 592  CTDLDSSPRSF-RYSIGPGNVNNHFTFSPN 620
              D D  P +   Y I  GN   +F   P+
Sbjct: 2753 AVDADEGPNAIVYYFIAAGNEEKNFHLQPD 2782



 Score =  117 bits (294), Expect = 4e-26
 Identities = 161/606 (26%), Positives = 248/606 (40%), Gaps = 81/606 (13%)

Query: 98   PNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGF-IYQ 155
            P I +L +  +D   +     L + + D N+  P F       L ++++E   PGF + Q
Sbjct: 2034 PPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS---PATLTVHLLENCPPGFSVLQ 2090

Query: 156  VEAFDPEDTSRNIPLSY---------FLISPPKSFRMSANGTLFSTTELDFEAGHRSFHL 206
            V A D ED+  N  L Y         FLI          N T+    +        S+ L
Sbjct: 2091 VTATD-EDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQ-------ESYRL 2142

Query: 207  IVEVRDSGGLKASTELQVNIV--NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPD 264
             V   D G +  S    V I+  ++ND  P F +P +  +VLE   PGT++ANITA D D
Sbjct: 2143 TVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD 2202

Query: 265  DEGFPSHLLYSITTVSK------------YFMINQLTGTIQVAQRIDRDAGELRQNPTIS 312
                P    + +  V+K             F +N  TG++ V   ++R   EL     ++
Sbjct: 2203 LN--PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNR---ELVATYEVT 2257

Query: 313  LEVL--VKDRPYGG-QENRIQITFIVEDVNDNPATCQKFTFSI---MVPERTAKGTLLLD 366
            L V+    D P         ++T  V DVNDN    + F  +     + E    GT L+ 
Sbjct: 2258 LSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIA 2317

Query: 367  LNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNK 426
            +      D  +  N    +T+   V  G   L+D + +GK++    +DYE    L     
Sbjct: 2318 VAAV---DPDKGLNGLVTYTLLDLVPPGYVQLED-SSAGKVIANRTVDYEEVHWL----- 2368

Query: 427  YTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRAT 486
                ++  D   P     + VY+     N+   IFD+PSY   V E  P  T +  V AT
Sbjct: 2369 -NFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTAT 2427

Query: 487  DKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA---- 541
            D D    +L+ YS+  G +       F INP TG++ +++ +D E    YIL   A    
Sbjct: 2428 DADSGNFALIEYSLGDGESK------FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 2481

Query: 542  ---TNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSS 598
                +N   +SV V + +L+ ND +P  +   +  ++  +   GT++    +  TD D  
Sbjct: 2482 GDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSV--ITMMATDQDEG 2539

Query: 599  PR-SFRYSI-GPGNVNNHFTFSPNAGSNVTRLLLTSRFDYA-----GGFDKIW-DYKLLV 650
            P     YS+ GPG    H        +    L    +F        GG   +W    LLV
Sbjct: 2540 PNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLV 2599

Query: 651  YVTDDN 656
             V D N
Sbjct: 2600 EVIDVN 2605



 Score =  114 bits (284), Expect = 5e-25
 Identities = 166/666 (24%), Positives = 262/666 (39%), Gaps = 69/666 (10%)

Query: 29   GNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEV---- 84
            G + EN P  T +    V+L A+     P   QI  S     AF      G+YF++    
Sbjct: 568  GALRENEPSVTQL----VRLRATDEDSPPN-NQITYSIVSASAF------GSYFDISLYE 616

Query: 85   ---VTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQV---LTVQVTDVNE-PPQFQGNLA 137
               V +    LD+E   N       +  + G   L     +T++V D N+ PP F     
Sbjct: 617  GYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFS---K 673

Query: 138  EGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS--FRMSANGTLFSTTEL 195
                + +VE    G           D SR       + S   S  FR++A     +TT L
Sbjct: 674  PAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSL 733

Query: 196  DFEAGHRSFHLIVEVRDSG-GLKASTEL---QVNIVNLNDEVPRFTSPTRVYTVLEELSP 251
                    + LIV   D G G    T +    + ++++ND  P +        ++E   P
Sbjct: 734  LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793

Query: 252  GTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQR-IDR---DAGELRQ 307
             + V  + A DPD  G    L+YSI   +K++ +N  TG I+     +DR   D  E   
Sbjct: 794  DSDVTTVVAVDPD-LGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAEL 852

Query: 308  NPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDL 367
               I + V    RP     +   +   + D+NDN  T Q   F   V E    G  +  +
Sbjct: 853  MRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQV 912

Query: 368  NKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKY 427
                 D   E  N   ++ MP G+      +   + SG +V   +LD E  +      +Y
Sbjct: 913  VAIDLD---EGLNGLVSYRMPVGMPRMDFLIN--SSSGVVVTTTELDRERIA------EY 961

Query: 428  TVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATD 487
             + +   D   P   +   + I     N+    F    Y   VSE  P   RV  +  TD
Sbjct: 962  QLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTD 1021

Query: 488  KDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--- 544
             D+  ++ L    TGG        F +  +   ++ V  +D ETT  Y+L ++A +N   
Sbjct: 1022 NDVGLNAELSYFITGG---NVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPV 1078

Query: 545  --EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSF 602
                T + TV V +L+ ND +PI   +SY  ++P D+  G +I   K T  D     R +
Sbjct: 1079 GKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVW 1138

Query: 603  RYSIGPGNVNNHFTFSPNAG------------SNVTRLLLTSRFDYAGGFDKIWDYKLLV 650
             Y I  GN  N+F    + G             N + +L+   +++  G  +    +++V
Sbjct: 1139 -YRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRS-SVRVIV 1196

Query: 651  YVTDDN 656
            YV D N
Sbjct: 1197 YVEDIN 1202



 Score =  112 bits (279), Expect = 2e-24
 Identities = 169/702 (24%), Positives = 288/702 (41%), Gaps = 106/702 (15%)

Query: 30  NVAENSPP-GTSVHKFSVKLSASLSPVIPGFPQIVNSNP---LTEAFRVNWLSGT--YFE 83
           ++ +N+P   +S +  ++   A +   +P F Q+V+ +    L   F V  +     +F 
Sbjct: 340 DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFI 399

Query: 84  VVTTGME-----------QLDFETGPNIFDLQIY----VKDEVGVTDLQVLTVQVTDVNE 128
           +  T ++            LD+ET    +D  ++    V D VG   +++  +   D   
Sbjct: 400 ISPTSVQGKADIRIRVAIPLDYETVDR-YDFDLFANESVPDHVGYAKVKITLINEND--N 456

Query: 129 PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN-G 187
            P F   L    ++ + E    G           D      +SYF    P  F +  + G
Sbjct: 457 RPIFSQPL---YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 513

Query: 188 TLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLE 247
            +     LD+E   R F L +  RD GG + +  +++N++++ND VP F     V  + E
Sbjct: 514 LIMLIARLDYELIQR-FTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRE 572

Query: 248 ELSPGTIVANITAEDPDDEGFPSHLLYSITTVS---KYFMIN--QLTGTIQVAQRIDRDA 302
                T +  + A D +D    + + YSI + S    YF I+  +  G I V++ +D   
Sbjct: 573 NEPSVTQLVRLRATD-EDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDY-- 629

Query: 303 GELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGT 362
            E   N  I L V+  D       + + +T  V D NDNP T  K  + + V E    G 
Sbjct: 630 -EQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGA 688

Query: 363 LLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLA 422
            +L LN    D   E       +++      GS   +  A SG+I     LD E  S   
Sbjct: 689 TVLFLNATDLDRSREYGQESIIYSL-----EGSTQFRINARSGEITTTSLLDRETKS--- 740

Query: 423 AGNKYTVIIQVQDVAPPYYKN----NVYVYILTSPENEFPLIFDRPSYVFDVSERRPART 478
              +Y +I++  D    + +      V + +L   +N  P   D P Y+ ++ E  P  +
Sbjct: 741 ---EYILIVRAVDGGVGHNQKTGIATVNITLLDINDNH-PTWKDAPYYI-NLVEMTPPDS 795

Query: 479 RVGQVRATDKDLPQS-SLLYSI-----------STGGASLQYPNVFWINPKTGELQLVTK 526
            V  V A D DL ++ +L+YSI           +TG     +  +   NP   E +L+ K
Sbjct: 796 DVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK 855

Query: 527 V-----DCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKV 581
           +     DC   P+          + TSS TV VN+L+ ND  P      +   +   +  
Sbjct: 856 IVVSVTDCGRPPL----------KATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905

Query: 582 GTNIQNFKLTCTDLDSSPR---SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAG 638
           G +I  +++   DLD       S+R  +G   ++    F  N+ S V  ++ T+  D   
Sbjct: 906 GVSI--YQVVAIDLDEGLNGLVSYRMPVGMPRMD----FLINSSSGV--VVTTTELDR-- 955

Query: 639 GFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVI 680
             ++I +Y+L V  +D         A    ++ T TL+I V+
Sbjct: 956 --ERIAEYQLRVVASD---------AGTPTKSSTSTLTIHVL 986



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 127/540 (23%), Positives = 221/540 (40%), Gaps = 66/540 (12%)

Query: 185  ANGTLFSTTELDFEAGHRSFHLIVEVRDSGGL--KASTELQVNIVNLNDEVPRFTSPTRV 242
            + G + +   LD+E    S+ + V   D      +    + + ++N  DE  +F++ +  
Sbjct: 1261 STGLIITVNYLDYET-KTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYE 1319

Query: 243  YTVLEELSPGTIVANITAEDPDDEGFPSHLL--YSITTVSKYFMINQLTGTIQVAQRIDR 300
              +LE L+ GT +  + A   D+    ++    Y+ T     F I+ +TG I V   +DR
Sbjct: 1320 AAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDR 1379

Query: 301  DAGELRQNPTISLEVLVKDRPYGGQ--ENRIQITFIVEDVNDNPATCQKFTFS----IMV 354
            + G+       +L V+  D   GG   ++ +++   V D NDN     +F F+    + +
Sbjct: 1380 EKGDF-----YTLTVVADD---GGPKVDSTVKVYITVLDENDNSP---RFDFTSDSAVSI 1428

Query: 355  PERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVL----I 410
            PE    G  +  +  +   D     N +  F++ SG         + AG+ +IV     I
Sbjct: 1429 PEDCPVGQRVATVKAW---DPDAGSNGQVVFSLASG---------NIAGAFEIVTTNDSI 1476

Query: 411  GDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP-SYVFD 469
            G++    P +    + Y + +   D   P  K +  + +     N+ P + + P  Y   
Sbjct: 1477 GEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVS 1536

Query: 470  VSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQL-VTKV 527
            V+E     T V QVRATD+D+  +S+L Y I+ G   +     F ++  +GE+       
Sbjct: 1537 VNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDM----AFRMDRISGEIATRPAPP 1592

Query: 528  DCETTPIYILRIQATNNEDTSSVTVT----VNILEENDEKPICTPNSYFLALPVDLKVGT 583
            D E    Y L +    +E T +++ T    V I++END  P+     Y + L        
Sbjct: 1593 DRERQSFYHL-VATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDT-L 1650

Query: 584  NIQNFKLTCTDLDSSPR-SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDK 642
            N     +   DLD  P  +  Y+I  GN+ N F    + G     +      DY     +
Sbjct: 1651 NTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV----ITAAKELDYEISHGR 1706

Query: 643  IWDYKLLVYVTDD-NLMSDR--KKAEALVETGTVTLSIKVIPH----PTTIITTTPRPRV 695
               Y L+V  TD   ++S R       LV    +  ++   P     P  +    P PRV
Sbjct: 1707 ---YTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRV 1763



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 137/551 (24%), Positives = 232/551 (42%), Gaps = 51/551 (9%)

Query: 71   AFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE-- 128
            AFR++ +SG     + T     D E   + + L   V+DE   T      V VT V+E  
Sbjct: 1575 AFRMDRISGE----IATRPAPPDRER-QSFYHLVATVEDEGTPTLSATTHVYVTIVDEND 1629

Query: 129  -PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPP--KSFRMSA 185
              P FQ    E L     +  N   I  ++A D  D   N  ++Y +++     +FR+  
Sbjct: 1630 NAPMFQQPHYEVLLDEGPDTLNTSLI-TIQALDL-DEGPNGTVTYAIVAGNIVNTFRIDR 1687

Query: 186  N-GTLFSTTELDFEAGHRSFHLIVEVRD-----SGGLKASTELQVNIVNLNDEVPRFTSP 239
            + G + +  ELD+E  H  + LIV   D     S  L ++T + VN+ ++ND VP F   
Sbjct: 1688 HMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRD 1747

Query: 240  TRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FMINQLTGTIQVAQR 297
                  + E  PG  V    A D  D G    + YSI        F+I+ + G ++V + 
Sbjct: 1748 YEGPFEVTEGQPGPRVWTFLAHD-RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKD 1806

Query: 298  IDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPER 357
            ++ D   +      +L +  +DR      + + +   V D+NDN         +I + E 
Sbjct: 1807 VELDRETI---AFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISEN 1863

Query: 358  TAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYEN 417
            +   + +  +     D DS   N R  F + +G    + F+   A +G + +   LD E 
Sbjct: 1864 SPVSSFVAHV--LASDADSGC-NARLTFNITAGNRERAFFIN--ATTGIVTVNRPLDRER 1918

Query: 418  PSNLAAGNKYTVIIQVQD-VAPPYYKNNVY--VYILTSPENEFPLIFDRPSYVFDVSERR 474
                    +Y + I V+D    P      Y  + I  S EN+   +F + +Y  +V E  
Sbjct: 1919 IP------EYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENS 1972

Query: 475  PARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKV----DCE 530
            PA T +  +      L     +Y++ T         +F IN  TG + + + V    +  
Sbjct: 1973 PAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAF 2032

Query: 531  TTPIYILRIQATNNED----TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586
            + PI  L + A   ED     S+  + + IL++ND +P  +P +  + L  +   G ++ 
Sbjct: 2033 SPPILELLLLA---EDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV- 2088

Query: 587  NFKLTCTDLDS 597
              ++T TD DS
Sbjct: 2089 -LQVTATDEDS 2098



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 107/411 (26%), Positives = 180/411 (43%), Gaps = 45/411 (10%)

Query: 243 YTVLEELSP-GTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRD 301
           Y ++ E +P G+ V  + A+D D++  P     S    S++F +   TG + + Q +DR+
Sbjct: 39  YLLISEDTPVGSSVTQLLAQDMDND--PLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRE 96

Query: 302 AGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361
                     ++E  V D  + G   R ++   V DVNDN  T     +S+ +PE T  G
Sbjct: 97  T-----KSEFTVEFSVSD--HQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVG 148

Query: 362 TLLLDLNKFCFDDDSEAPNN-RFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN 420
           T +  +N    D D  A  +  ++F  P      S+F    +  G + +I +LDYE    
Sbjct: 149 TPIFIVN--ATDPDLGAGGSVLYSFQPP------SQFFAIDSARGIVTVIRELDYET--- 197

Query: 421 LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV 480
                + TV    QD   P         I+T  ++  P+  + P Y  ++ E  P  T V
Sbjct: 198 -TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP-YSTNIYEHSPPGTTV 255

Query: 481 GQVRATDKDLPQ-SSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIY---- 535
             + A D+D  +   + Y+I +G  +    ++F ++  +G L L   +D E  P+Y    
Sbjct: 256 RIITAIDQDKGRPRGIGYTIVSGNTN----SIFALDYISGVLTLNGLLDRE-NPLYSHGF 310

Query: 536 ILRIQATNNED-----TSSVTVTVNIL--EENDEKPICTPNSYFLALPVDLKVGTNIQNF 588
           IL ++ T   D      ++VT T NIL  + ND  P    + Y +A+    +VG  +  F
Sbjct: 311 ILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF 370

Query: 589 -KLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNA--GSNVTRLLLTSRFDY 636
            ++   D +    S       GN ++HF  SP +  G    R+ +    DY
Sbjct: 371 IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDY 421



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 124/551 (22%), Positives = 221/551 (40%), Gaps = 46/551 (8%)

Query: 180  SFRMSANGTLFSTTELDFEAGHRSFH-LIVEV--RDSGGLKASTELQVNIVNLNDEVPRF 236
            +FR+  +  L        +    S H LIVE    D G +++S  + V + ++NDE P F
Sbjct: 1149 NFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVF 1208

Query: 237  TSPTRVYTVLEE---LSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
            T        L E   +    IV   T  D  D G  ++ +  ++     F I++ TG I 
Sbjct: 1209 TQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRI--LSGAEGKFEIDESTGLII 1266

Query: 294  VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIM 353
                +D    E + +  +++    +  P+      + IT + E   D        ++   
Sbjct: 1267 TVNYLDY---ETKTSYMMNVSATDQAPPFNQGFCSVYITLLNE--LDEAVQFSNASYEAA 1321

Query: 354  VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413
            + E  A GT ++ +  +  D+ ++     + F   +   + + F  D A +G I + G +
Sbjct: 1322 ILENLALGTEIVRVQAYSIDNLNQI---TYRFNAYTSTQAKALFKID-AITGVITVQGLV 1377

Query: 414  DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPS-YVFDVSE 472
            D E       G+ YT+ + V D   P   + V VYI    EN+    FD  S     + E
Sbjct: 1378 DREK------GDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPE 1430

Query: 473  RRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531
              P   RV  V+A D D      +++S+++G  +  +  +   N   GE+ +   +D E 
Sbjct: 1431 DCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAF-EIVTTNDSIGEVFVARPLDREE 1489

Query: 532  TPIYILRIQATNN---EDTSSVTVTVNILEENDEKPIC-TPNSYFLALPVDLKVGTNIQN 587
               YIL++ A++           + V IL+ ND  P+  +P  Y +++  ++  GT +  
Sbjct: 1490 LDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQ 1549

Query: 588  FKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTR-------------LLLTSRF 634
             + T  D+  +     Y I  GN +  F     +G   TR             L+ T   
Sbjct: 1550 VRATDRDIGIN-SVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVED 1608

Query: 635  DYAGGFDKIWD-YKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPHPTTIITTTPRP 693
            +           Y  +V   D+  M  +   E L++ G  TL+  +I      +   P  
Sbjct: 1609 EGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNG 1668

Query: 694  RVTYQVLRKNV 704
             VTY ++  N+
Sbjct: 1669 TVTYAIVAGNI 1679



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 121/566 (21%), Positives = 220/566 (38%), Gaps = 91/566 (16%)

Query: 187 GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVL 246
           G ++    LD E     F +   V D  G+  + ++ + + ++ND  P F +      + 
Sbjct: 85  GVVWLRQPLDRET-KSEFTVEFSVSDHQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIP 142

Query: 247 EELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELR 306
           E    GT +  + A DP D G    +LYS    S++F I+   G + V + +D +  +  
Sbjct: 143 ENTPVGTPIFIVNATDP-DLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAY 201

Query: 307 QNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLD 366
           Q  T++     K RP     N   +  I+ DV D         +S  + E +  GT +  
Sbjct: 202 Q-LTVNATDQDKTRPLSTLAN---LAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRI 257

Query: 367 LNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYEN--------- 417
           +     D D   P     +T+ SG  + S F  D   SG + L G LD EN         
Sbjct: 258 IT--AIDQDKGRPRG-IGYTIVSG-NTNSIFALDYI-SGVLTLNGLLDRENPLYSHGFIL 312

Query: 418 ------------PSNLAAGNKYTV-IIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP 464
                       PS+      + + +I + D AP +  +   V I    +  F L    P
Sbjct: 313 TVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL----P 368

Query: 465 SYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGE---- 520
            ++              QV   D++L  +S+      G  S    + F I+P + +    
Sbjct: 369 LFI--------------QVVDKDENLGLNSMFEVYLVGNNS----HHFIISPTSVQGKAD 410

Query: 521 --LQLVTKVDCETTPIYILRIQATNN--EDTSSVTVTVNILEENDEKPICTPNSYFLALP 576
             +++   +D ET   Y   + A  +  +      V + ++ END +PI +   Y ++L 
Sbjct: 411 IRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLY 470

Query: 577 VDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGS---NVTRLLLTSR 633
            ++ VGT++    LT    D+   +F      G V+  F+  P+  S   +   ++L +R
Sbjct: 471 ENVTVGTSV----LTVLATDNDAGTF------GEVSYFFSDDPDRFSLDKDTGLIMLIAR 520

Query: 634 FDY--------------AGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKV 679
            DY               GG +     ++ V   +DN+ + +K A             ++
Sbjct: 521 LDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQL 580

Query: 680 IPHPTTIITTTPRPRVTYQVLRKNVY 705
           +    T   + P  ++TY ++  + +
Sbjct: 581 VRLRATDEDSPPNNQITYSIVSASAF 606



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 99/415 (23%), Positives = 179/415 (43%), Gaps = 63/415 (15%)

Query: 119  LTVQVTDVNE------PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSY 172
            + +QV DVN+       PQF  ++ E       E A    I  +     +D   N  L+Y
Sbjct: 2495 VVIQVLDVNDCRPQFSKPQFSTSVYEN------EPAGTSVITMMAT--DQDEGPNGELTY 2546

Query: 173  FLISPP-KSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNL 229
             L  P  ++F +  +  L  TT+   ++ +  F L V   D G   L  +T L V ++++
Sbjct: 2547 SLEGPGVEAFHVDMDSGLV-TTQRPLQS-YEKFSLTVVATDGGEPPLWGTTMLLVEVIDV 2604

Query: 230  NDEVPRFTSPTR--VYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS-----KY 282
            ND  P F  P    +  + EE+   + V  + A D D EG    + YS    +     ++
Sbjct: 2605 NDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKD-EGLNGAVRYSFLKTAGNRDWEF 2663

Query: 283  FMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDN- 341
            F+I+ ++G IQ AQR+DR++  +     ++ + L +  PY   E    +   +ED++DN 
Sbjct: 2664 FIIDPISGLIQTAQRLDRESQAVYSLILVASD-LGQPVPY---ETMQPLQVALEDIDDNE 2719

Query: 342  ------PATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGS 395
                  P    ++   + VPE + +GTL+ ++      D  E PN    + + +G    +
Sbjct: 2720 PLFVRPPKGSPQYQL-LTVPEHSPRGTLVGNVTGAV--DADEGPNAIVYYFIAAGNEEKN 2776

Query: 396  RFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV---QDVAPPYYKNNVY------ 446
              LQ     G ++++ DLD E  +       ++ I++    +   PP   +         
Sbjct: 2777 FHLQP---DGCLLVLRDLDREREA------IFSFIVKASSNRSWTPPRGPSPTLDLVADL 2827

Query: 447  ----VYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLY 497
                V ++    N+ P  F +  Y   V+      + + QV A D D+  +SL++
Sbjct: 2828 TLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 139/596 (23%), Positives = 224/596 (37%), Gaps = 113/596 (18%)

Query: 80   TYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEG 139
            T  ++V  G  QL+  +   +   +    +EV   +    TV+ +D   PP+    +   
Sbjct: 2334 TLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNF---TVRASDNGSPPR-AAEIPVY 2389

Query: 140  LHLYIVERANPGF---IYQVEAFDP--------------EDTSRNIPLSYFLISPPKSFR 182
            L +  +   NP F    YQ   F+                D+     + Y L      F 
Sbjct: 2390 LEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFA 2449

Query: 183  MS-ANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKAST------ELQVNIVNLNDEVPR 235
            ++   G ++  + LD E     + L    +D+ G  AS       ++ + ++++ND  P+
Sbjct: 2450 INPTTGDIYVLSSLDREKKDH-YILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQ 2508

Query: 236  FTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVA 295
            F+ P    +V E    GT V  + A D  DEG    L YS            L G    A
Sbjct: 2509 FSKPQFSTSVYENEPAGTSVITMMATD-QDEGPNGELTYS------------LEGPGVEA 2555

Query: 296  QRIDRDAG------ELRQNPTISLEVLVKDRPYGGQENRIQITFI---VEDVNDNPATCQ 346
              +D D+G       L+     SL V+  D   GG+      T +   V DVNDN     
Sbjct: 2556 FHVDMDSGLVTTQRPLQSYEKFSLTVVATD---GGEPPLWGTTMLLVEVIDVNDNRP--- 2609

Query: 347  KFTFSIMVPERTAKGTLL-----LDLNKFCFD----DDSEAPNN--RFNFTMPSGVGSGS 395
                   V  R   GT+L     + L    ++    D  E  N   R++F   +G     
Sbjct: 2610 -------VFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWE 2662

Query: 396  RFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY-YKNNVYVYILTSPE 454
             F+ DP  SG I     LD E+ +       Y++I+   D+  P  Y+    + +     
Sbjct: 2663 FFIIDPI-SGLIQTAQRLDRESQA------VYSLILVASDLGQPVPYETMQPLQVALEDI 2715

Query: 455  NEFPLIFDRPS------YVFDVSERRPARTRVGQVR-ATDKDL-PQSSLLYSISTGGASL 506
            ++   +F RP        +  V E  P  T VG V  A D D  P + + Y I+ G    
Sbjct: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEK 2775

Query: 507  QYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNE----------------DTSSV 550
                 F + P  G L ++  +D E   I+   ++A++N                 D +  
Sbjct: 2776 N----FHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQ 2830

Query: 551  TVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSI 606
             V V + + ND+ P  T   Y   +  D KVG+ +        D+ ++   F YSI
Sbjct: 2831 EVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF-YSI 2885


>gi|203097724 cadherin-like 29 [Homo sapiens]
          Length = 788

 Score =  127 bits (320), Expect = 3e-29
 Identities = 200/852 (23%), Positives = 329/852 (38%), Gaps = 120/852 (14%)

Query: 5   IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSA-SLSPVIPGFPQIV 63
           ++LL LL  +       L  LP   NV+E+  PGT +   S   S+ + +P +    +++
Sbjct: 1   MVLLRLLVFLFAPVVSDLCSLPCFINVSESQGPGTVLQFLSFNCSSYTPTPTL----ELL 56

Query: 64  NSNPLTEAFRVNWLS---GTYFEVVTTGME-------------QLDFETGPNIFDLQIYV 107
           N  P T  F    L+   GTY   +T                 QL F  G ++ +  + V
Sbjct: 57  NVQPPTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLSV 116

Query: 108 KDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIY---QVEAFDPEDT 164
             +  ++ +Q      +   E  Q    +  G  LY +    PG      Q+     +D 
Sbjct: 117 DVQRDLSHIQCAGQFASPAGEMIQVPETVTPGARLYTL--LLPGLELHGAQMSIISAQD- 173

Query: 165 SRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQV 224
                L +F    P  F ++  G L + ++       + F L + V           + V
Sbjct: 174 -----LPHF----PGPFSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSCQGMVIV 224

Query: 225 NIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTV--SKY 282
            ++ +      F    +  T+ E L+PG+ V  + A   D       L Y I +   S  
Sbjct: 225 KVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVD-------LRYEILSPVPSPL 277

Query: 283 FMINQLTGTIQVAQRID--RDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVND 340
           F I +  G ++    ++  R +G         L+V   ++       ++ +T  V+ VN 
Sbjct: 278 FSIGRADGVVRTTTPLELARTSG----TAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNL 333

Query: 341 NPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQD 400
            P  C        +PE    GT+L  L   C D DS      +     S     S  L D
Sbjct: 334 WPPRCLPALLVSQIPETAPVGTVLNTLT--CEDPDSVGATLDYKLWFRSSSNPASLCLYD 391

Query: 401 PAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEF-PL 459
                 + +   LD + P    A  ++   I V D   P     V V ++ +P NEF P 
Sbjct: 392 RV----LEVNATLDCDTPG---ACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPA 444

Query: 460 IFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTG 519
              R    F V E     T +G V  TD D P  ++ Y  S G      P  F ++  +G
Sbjct: 445 CAPR---TFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGG------PTTFAVDRLSG 495

Query: 520 ELQLVTKVDCETTPIYILRI--------QATNNEDTSSVTVTVNILEENDEKPICTPNSY 571
           E+ L+  +D E   +Y L +        Q  N+  + S T+T+ + + ND  P C P   
Sbjct: 496 EVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPP-- 553

Query: 572 FLALPVDLKVGTNIQNFKLTCTDLDSSPRS--FRYSIGPGNVNNHFTFSPNAGSNVTRLL 629
           F  L +   +G +++  K++C  +   P+   + YSI  GN  N F             +
Sbjct: 554 FQELTIYAPLGRSVEVTKMSC-QIPQEPQRLIYSYSIVGGNSQNRFILQG--------AI 604

Query: 630 LTSRFDYAGGF--DKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPH-PTTI 686
           L       G F  ++   Y+LL+ V D    +            T T+ + ++P   +T+
Sbjct: 605 LVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLST-------TATIIVHLVPRRASTV 657

Query: 687 ITTTPRPRVTYQVLRKNV------YSPSAWYVPFVITLGSILLLGL---LVYLVVLLAKA 737
            T+T R  V   +    V      + P  W+V  +   G++LLL L   L  L+  LA+ 
Sbjct: 658 ATSTHRTTVPSTMTPMLVTDTEAFWQPQPWFVVVLTATGALLLLALGWLLGRLLQGLAQL 717

Query: 738 IHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTI--------FDGEAIDPVTGET 789
           +    P K  +     + +G   + E  +    ++M+          FDG A D  TG  
Sbjct: 718 LQ--APSKPAQALLLNSIQGTEGSIEGFLEAPKMEMSQAPSSVMSLHFDGRAQDSRTGRD 775

Query: 790 YEFNSKTGARKW 801
           Y FN+ TGAR+W
Sbjct: 776 YLFNTHTGARRW 787


>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
          Length = 790

 Score =  124 bits (312), Expect = 3e-28
 Identities = 122/464 (26%), Positives = 201/464 (43%), Gaps = 31/464 (6%)

Query: 187 GTLFSTTELDFEAG-HRSFHL-IVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYT 244
           G + ST  LD E   H   H   ++ R +  L+  +E  + + ++ND  P+FT    + T
Sbjct: 108 GDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVT 167

Query: 245 VLEELSPGTIVANITAEDPDDE--GFPSHLLYSITTVSKYFMINQLTGTIQVA-QRIDRD 301
           V E    GT V  +TA D DD   G  + ++YSI     YF ++  TG I+ A   +DR+
Sbjct: 168 VPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDRE 227

Query: 302 AGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361
           A   R++ ++ ++        GG      +   + DVNDNP    +  + + VPE    G
Sbjct: 228 A---REHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQVG 284

Query: 362 TLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNL 421
           +    + K   +D     N    +++ +G G G   +     + K    G L  + P N 
Sbjct: 285 SA---VGKIKANDADTGSNADMTYSIINGDGMGIFSI----STDKETREGILSLKKPLNY 337

Query: 422 AAGNKYTVIIQVQDVAPPY-------YKNNVYVYILTSPENEFPLIFDRPSYVFDVSERR 474
                YT+ I+  +    +       +K+   + I+    +E PL F  PSY+ +V E  
Sbjct: 338 EKKKSYTLNIEGANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPL-FSMPSYLMEVYENA 396

Query: 475 PARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPI 534
              T VG V A D D   S + Y I+    +++    F I+  TG ++    +D E TP 
Sbjct: 397 KIGTVVGTVLAQDPDSTNSLVRYFIN---YNVEDDRFFNIDANTGTIRTTKVLDREETPW 453

Query: 535 YILRIQAT---NNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLT 591
           Y + + A+   N +  S VTV + +L+ ND  P      Y + +  + K G  I     T
Sbjct: 454 YNITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELA-REYDIIVCENSKPGQVIHTISAT 512

Query: 592 CTDLDSSPRSFRYSIGPG-NVNNHFTFSPNAGSNVTRLLLTSRF 634
             D  ++   F + +     VN +FT   N  +  + L    RF
Sbjct: 513 DKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRF 556



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 43/157 (27%), Positives = 71/157 (45%), Gaps = 12/157 (7%)

Query: 115 DLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIY-QVEAFDPEDTSRNIPLSYF 173
           D  +L + V DV+EPP F         + + E A  G +   V A DP+ T  N  + YF
Sbjct: 366 DATMLKIIVGDVDEPPLFS---MPSYLMEVYENAKIGTVVGTVLAQDPDST--NSLVRYF 420

Query: 174 L---ISPPKSFRMSAN-GTLFSTTELD-FEAGHRSFHLIVEVRDSGGLKASTELQVNIVN 228
           +   +   + F + AN GT+ +T  LD  E    +  +     D+  L +   + + +++
Sbjct: 421 INYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDLLSHVTVGIRVLD 480

Query: 229 LNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDD 265
           +ND  P       +  V E   PG ++  I+A D DD
Sbjct: 481 VNDNPPELAREYDI-IVCENSKPGQVIHTISATDKDD 516



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 36/145 (24%), Positives = 60/145 (41%), Gaps = 16/145 (11%)

Query: 486 TDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA---- 541
           ++ D    S+ Y ++  GA      +F I+  TG++     +D E    Y+L  QA    
Sbjct: 79  SNSDKGDGSVKYILTGEGAG----TIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRR 134

Query: 542 TNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLD----S 597
           TN          + + + ND  P  T   Y + +P    +GT++   ++T TD D     
Sbjct: 135 TNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDMGTSV--LQVTATDADDPTYG 192

Query: 598 SPRSFRYSIGPGNVNNHFTFSPNAG 622
           +     YSI  G    +F+  P  G
Sbjct: 193 NSARVVYSILQG--QPYFSVDPKTG 215


>gi|11056063 protocadherin gamma subfamily A, 7 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  124 bits (310), Expect = 5e-28
 Identities = 136/540 (25%), Positives = 235/540 (43%), Gaps = 57/540 (10%)

Query: 69  TEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE 128
           T+ F +N  SG+         E++  ++   + +  I ++D++   +L  + V++ D+N+
Sbjct: 72  TQLFALNQRSGSLVTAGRIDREEICAQSARCLVNFNILMEDKM---NLYPIDVEIIDIND 128

Query: 129 P-PQFQGNLAEGLHLYIVERANPGFIYQV-EAFDPEDTSRNIPLSYFLISPPKSFRMSAN 186
             P+F   L E +++ I+E   PG  + + EA DP D   N   SY L SP + F ++  
Sbjct: 129 NVPRF---LTEEINVKIMENTAPGVRFPLSEAGDP-DVGTNSLQSYQL-SPNRHFSLAVQ 183

Query: 187 G--------TLFSTTELDFEAGHRSFHLIVEVRDSGGLKAST--ELQVNIVNLNDEVPRF 236
                     L     LD E   R  HL++   D G    S+   +QV +V++ND  P F
Sbjct: 184 SGDDETKYPELVLERVLDREE-ERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVF 242

Query: 237 TSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS----KYFMINQLTGTI 292
           + P    TV E +  GT +  + A D  DEG    + YS   ++    K F +N LTG I
Sbjct: 243 SLPQYQVTVPENVPVGTRLLTVHAIDL-DEGVNGEVTYSFRKITPKLPKMFHLNSLTGEI 301

Query: 293 QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352
              + +D +     +     +EV  +D P  G   + ++   V DVNDN       + S 
Sbjct: 302 STLEGLDYE-----ETAFYEMEVQAQDGP--GSLTKAKVLITVLDVNDNAPEVTMTSLSS 354

Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412
            +PE T  GT++     F   D     N     T+P  +    +  +      ++V   +
Sbjct: 355 SIPEDTPLGTVIA---LFYLQDRDSGKNGEVTCTIPENL--PFKLEKSIDNYYRLVTTKN 409

Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472
           LD E  S       Y + ++  D   P      ++++  +  N+ P  F   SY   ++E
Sbjct: 410 LDRETLS------LYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAE 463

Query: 473 RRPARTRVGQVRATDKDLPQSS-LLYSISTG---GASLQYPNVFWINPKTGELQLVTKVD 528
             P    +  V A D D   ++ + YS++     GA +   +   IN  TG L  +   D
Sbjct: 464 NNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVS--SYVSINSDTGVLYALQSFD 521

Query: 529 CETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI 585
            E      LR+ A ++ D   +S++++++ +L++ND      P   + ALP D   G  +
Sbjct: 522 YEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDN----PPEILYPALPTDGSTGMEL 577



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 94/391 (24%), Positives = 158/391 (40%), Gaps = 50/391 (12%)

Query: 242 VYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTV-----SKYFMINQLTGTIQVAQ 296
           +Y+V EE   G+ V +I A+D   E  P  L      +     ++ F +NQ +G++  A 
Sbjct: 32  LYSVSEETDKGSFVGDI-AKDLGLE--PRELAERGVRIISRGRTQLFALNQRSGSLVTAG 88

Query: 297 RIDRDAGELRQ-NPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVP 355
           RIDR+    +     ++  +L++D+      N   I   + D+NDN         ++ + 
Sbjct: 89  RIDREEICAQSARCLVNFNILMEDKM-----NLYPIDVEIIDINDNVPRFLTEEINVKIM 143

Query: 356 ERTAKGTLLL-------DLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408
           E TA G           D+          +PN  F+  + SG         D     ++V
Sbjct: 144 ENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSG--------DDETKYPELV 195

Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468
           L   LD E          + +++   D   P   +  ++ +     N+   +F  P Y  
Sbjct: 196 LERVLDREEE------RVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV 249

Query: 469 DVSERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKV 527
            V E  P  TR+  V A D D      + YS       L  P +F +N  TGE+  +  +
Sbjct: 250 TVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKL--PKMFHLNSLTGEISTLEGL 307

Query: 528 DCETTPIYILRIQATNNEDT-SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI- 585
           D E T  Y + +QA +   + +   V + +L+ ND  P  T  S   ++P D  +GT I 
Sbjct: 308 DYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIA 367

Query: 586 ----------QNFKLTCTDLDSSPRSFRYSI 606
                     +N ++TCT  ++ P     SI
Sbjct: 368 LFYLQDRDSGKNGEVTCTIPENLPFKLEKSI 398


>gi|14196477 protocadherin gamma subfamily A, 7 isoform 2 precursor
           [Homo sapiens]
          Length = 817

 Score =  124 bits (310), Expect = 5e-28
 Identities = 136/540 (25%), Positives = 235/540 (43%), Gaps = 57/540 (10%)

Query: 69  TEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE 128
           T+ F +N  SG+         E++  ++   + +  I ++D++   +L  + V++ D+N+
Sbjct: 72  TQLFALNQRSGSLVTAGRIDREEICAQSARCLVNFNILMEDKM---NLYPIDVEIIDIND 128

Query: 129 P-PQFQGNLAEGLHLYIVERANPGFIYQV-EAFDPEDTSRNIPLSYFLISPPKSFRMSAN 186
             P+F   L E +++ I+E   PG  + + EA DP D   N   SY L SP + F ++  
Sbjct: 129 NVPRF---LTEEINVKIMENTAPGVRFPLSEAGDP-DVGTNSLQSYQL-SPNRHFSLAVQ 183

Query: 187 G--------TLFSTTELDFEAGHRSFHLIVEVRDSGGLKAST--ELQVNIVNLNDEVPRF 236
                     L     LD E   R  HL++   D G    S+   +QV +V++ND  P F
Sbjct: 184 SGDDETKYPELVLERVLDREE-ERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVF 242

Query: 237 TSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS----KYFMINQLTGTI 292
           + P    TV E +  GT +  + A D  DEG    + YS   ++    K F +N LTG I
Sbjct: 243 SLPQYQVTVPENVPVGTRLLTVHAIDL-DEGVNGEVTYSFRKITPKLPKMFHLNSLTGEI 301

Query: 293 QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352
              + +D +     +     +EV  +D P  G   + ++   V DVNDN       + S 
Sbjct: 302 STLEGLDYE-----ETAFYEMEVQAQDGP--GSLTKAKVLITVLDVNDNAPEVTMTSLSS 354

Query: 353 MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412
            +PE T  GT++     F   D     N     T+P  +    +  +      ++V   +
Sbjct: 355 SIPEDTPLGTVIA---LFYLQDRDSGKNGEVTCTIPENL--PFKLEKSIDNYYRLVTTKN 409

Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472
           LD E  S       Y + ++  D   P      ++++  +  N+ P  F   SY   ++E
Sbjct: 410 LDRETLS------LYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAE 463

Query: 473 RRPARTRVGQVRATDKDLPQSS-LLYSISTG---GASLQYPNVFWINPKTGELQLVTKVD 528
             P    +  V A D D   ++ + YS++     GA +   +   IN  TG L  +   D
Sbjct: 464 NNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVS--SYVSINSDTGVLYALQSFD 521

Query: 529 CETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI 585
            E      LR+ A ++ D   +S++++++ +L++ND      P   + ALP D   G  +
Sbjct: 522 YEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDN----PPEILYPALPTDGSTGMEL 577



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 94/391 (24%), Positives = 158/391 (40%), Gaps = 50/391 (12%)

Query: 242 VYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTV-----SKYFMINQLTGTIQVAQ 296
           +Y+V EE   G+ V +I A+D   E  P  L      +     ++ F +NQ +G++  A 
Sbjct: 32  LYSVSEETDKGSFVGDI-AKDLGLE--PRELAERGVRIISRGRTQLFALNQRSGSLVTAG 88

Query: 297 RIDRDAGELRQ-NPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVP 355
           RIDR+    +     ++  +L++D+      N   I   + D+NDN         ++ + 
Sbjct: 89  RIDREEICAQSARCLVNFNILMEDKM-----NLYPIDVEIIDINDNVPRFLTEEINVKIM 143

Query: 356 ERTAKGTLLL-------DLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408
           E TA G           D+          +PN  F+  + SG         D     ++V
Sbjct: 144 ENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSG--------DDETKYPELV 195

Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468
           L   LD E          + +++   D   P   +  ++ +     N+   +F  P Y  
Sbjct: 196 LERVLDREEE------RVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV 249

Query: 469 DVSERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKV 527
            V E  P  TR+  V A D D      + YS       L  P +F +N  TGE+  +  +
Sbjct: 250 TVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKL--PKMFHLNSLTGEISTLEGL 307

Query: 528 DCETTPIYILRIQATNNEDT-SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI- 585
           D E T  Y + +QA +   + +   V + +L+ ND  P  T  S   ++P D  +GT I 
Sbjct: 308 DYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIA 367

Query: 586 ----------QNFKLTCTDLDSSPRSFRYSI 606
                     +N ++TCT  ++ P     SI
Sbjct: 368 LFYLQDRDSGKNGEVTCTIPENLPFKLEKSI 398


>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
          Length = 1955

 Score =  122 bits (306), Expect = 1e-27
 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)

Query: 28   TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
            T   A+N+PP     S+    +++    +   P FPQ++ S  ++EA RV  +       
Sbjct: 582  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641

Query: 78   -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
                 S TY          F +  TTG+    + LD E+      +          T   
Sbjct: 642  DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
             + + VTDVN+  P F   L   L   +VE     F+ QV+A DP D   N  + Y L +
Sbjct: 702  TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758

Query: 177  PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
                FR+++NG++++  +L+ E   R ++ +V V   G +    ++  L + +++++D  
Sbjct: 759  FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816

Query: 234  PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
            P FT+ T    V E L  GT +  I A+D D     S+ + S   V  +F ++  TG + 
Sbjct: 817  PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875

Query: 294  VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
            + + +D +A    Q  +I+  V   D  YG     I  +T IV+D+ND P    K  +  
Sbjct: 876  LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
            MV     KGT +  +    + +D++ P           +   F  P+ +       +   
Sbjct: 934  MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983

Query: 403  GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
             SG+++   +L+ E P+ +     + +++   D   P   ++  V IL     E P    
Sbjct: 984  DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037

Query: 463  RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
                   VSE     T VG + A   +    S++YSI +G       + F IN  TG + 
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090

Query: 523  LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
            +   +D ET   Y+LR+QA + E           +++  V + I +EN+  P+     Y 
Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150

Query: 573  LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
              +  D ++ T++   K T  D  + S  ++R  I P       F      G   T +L 
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210

Query: 631  -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
               R  Y         +K  V  TDD       KA+ LV     + + + V   P T++
Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260



 Score =  111 bits (278), Expect = 3e-24
 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)

Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
           PG +Y +    PED  R      F    P++  +S    L      DF   H+ F L+++
Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366

Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
                G  L A   L + I++ N++ P FT P+    +LE    G  ++   N+T+    
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426

Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
               +D +D   P   L+ +   +  F + Q  +T  + + Q +DR+     +  T +  
Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480

Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
           +   D   G QE+   I  I V D NDN  T  + ++ + V      G  ++ L     D
Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537

Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
           + S         T    VG+   F+ +   +G I +   ++      +  G  Y + +Q 
Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585

Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
            D APP  + N    VY+ +L  P N+ P  F +  Y  ++SE       +  ++ATD++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644

Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
               S+ Y+I  G        VF ++  TG L L   +D E+T  YIL I A++   + T
Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698

Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
           S+ TV + + + ND  P+  P      LP +L V     N    ++  TD D+       
Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753

Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
           YS+  GN NN F  + N GS  T + L           ++ DY  LV V  D  +  R  
Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800

Query: 664 AEALVETGTVTLSIKVI 680
                   T+TL+IKV+
Sbjct: 801 -------STLTLAIKVL 810


>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
          Length = 1932

 Score =  122 bits (306), Expect = 1e-27
 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)

Query: 28   TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
            T   A+N+PP     S+    +++    +   P FPQ++ S  ++EA RV  +       
Sbjct: 560  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 619

Query: 78   -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
                 S TY          F +  TTG+    + LD E+      +          T   
Sbjct: 620  DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 679

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
             + + VTDVN+  P F   L   L   +VE     F+ QV+A DP D   N  + Y L +
Sbjct: 680  TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 736

Query: 177  PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
                FR+++NG++++  +L+ E   R ++ +V V   G +    ++  L + +++++D  
Sbjct: 737  FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 794

Query: 234  PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
            P FT+ T    V E L  GT +  I A+D D     S+ + S   V  +F ++  TG + 
Sbjct: 795  PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 853

Query: 294  VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
            + + +D +A    Q  +I+  V   D  YG     I  +T IV+D+ND P    K  +  
Sbjct: 854  LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 911

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
            MV     KGT +  +    + +D++ P           +   F  P+ +       +   
Sbjct: 912  MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 961

Query: 403  GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
             SG+++   +L+ E P+ +     + +++   D   P   ++  V IL     E P    
Sbjct: 962  DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1015

Query: 463  RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
                   VSE     T VG + A   +    S++YSI +G       + F IN  TG + 
Sbjct: 1016 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1068

Query: 523  LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
            +   +D ET   Y+LR+QA + E           +++  V + I +EN+  P+     Y 
Sbjct: 1069 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1128

Query: 573  LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
              +  D ++ T++   K T  D  + S  ++R  I P       F      G   T +L 
Sbjct: 1129 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1188

Query: 631  -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
               R  Y         +K  V  TDD       KA+ LV     + + + V   P T++
Sbjct: 1189 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238



 Score =  111 bits (278), Expect = 3e-24
 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)

Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
           PG +Y +    PED  R      F    P++  +S    L      DF   H+ F L+++
Sbjct: 298 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 344

Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
                G  L A   L + I++ N++ P FT P+    +LE    G  ++   N+T+    
Sbjct: 345 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 404

Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
               +D +D   P   L+ +   +  F + Q  +T  + + Q +DR+     +  T +  
Sbjct: 405 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 458

Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
           +   D   G QE+   I  I V D NDN  T  + ++ + V      G  ++ L     D
Sbjct: 459 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515

Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
           + S         T    VG+   F+ +   +G I +   ++      +  G  Y + +Q 
Sbjct: 516 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 563

Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
            D APP  + N    VY+ +L  P N+ P  F +  Y  ++SE       +  ++ATD++
Sbjct: 564 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 622

Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
               S+ Y+I  G        VF ++  TG L L   +D E+T  YIL I A++   + T
Sbjct: 623 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 676

Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
           S+ TV + + + ND  P+  P      LP +L V     N    ++  TD D+       
Sbjct: 677 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 731

Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
           YS+  GN NN F  + N GS  T + L           ++ DY  LV V  D  +  R  
Sbjct: 732 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 778

Query: 664 AEALVETGTVTLSIKVI 680
                   T+TL+IKV+
Sbjct: 779 -------STLTLAIKVL 788


>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
          Length = 1677

 Score =  122 bits (306), Expect = 1e-27
 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)

Query: 28   TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
            T   A+N+PP     S+    +++    +   P FPQ++ S  ++EA RV  +       
Sbjct: 582  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641

Query: 78   -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
                 S TY          F +  TTG+    + LD E+      +          T   
Sbjct: 642  DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
             + + VTDVN+  P F   L   L   +VE     F+ QV+A DP D   N  + Y L +
Sbjct: 702  TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758

Query: 177  PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
                FR+++NG++++  +L+ E   R ++ +V V   G +    ++  L + +++++D  
Sbjct: 759  FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816

Query: 234  PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
            P FT+ T    V E L  GT +  I A+D D     S+ + S   V  +F ++  TG + 
Sbjct: 817  PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875

Query: 294  VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
            + + +D +A    Q  +I+  V   D  YG     I  +T IV+D+ND P    K  +  
Sbjct: 876  LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
            MV     KGT +  +    + +D++ P           +   F  P+ +       +   
Sbjct: 934  MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983

Query: 403  GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
             SG+++   +L+ E P+ +     + +++   D   P   ++  V IL     E P    
Sbjct: 984  DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037

Query: 463  RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
                   VSE     T VG + A   +    S++YSI +G       + F IN  TG + 
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090

Query: 523  LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
            +   +D ET   Y+LR+QA + E           +++  V + I +EN+  P+     Y 
Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150

Query: 573  LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
              +  D ++ T++   K T  D  + S  ++R  I P       F      G   T +L 
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210

Query: 631  -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
               R  Y         +K  V  TDD       KA+ LV     + + + V   P T++
Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260



 Score =  111 bits (278), Expect = 3e-24
 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)

Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
           PG +Y +    PED  R      F    P++  +S    L      DF   H+ F L+++
Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366

Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
                G  L A   L + I++ N++ P FT P+    +LE    G  ++   N+T+    
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426

Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
               +D +D   P   L+ +   +  F + Q  +T  + + Q +DR+     +  T +  
Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480

Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
           +   D   G QE+   I  I V D NDN  T  + ++ + V      G  ++ L     D
Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537

Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
           + S         T    VG+   F+ +   +G I +   ++      +  G  Y + +Q 
Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585

Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
            D APP  + N    VY+ +L  P N+ P  F +  Y  ++SE       +  ++ATD++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644

Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
               S+ Y+I  G        VF ++  TG L L   +D E+T  YIL I A++   + T
Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698

Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
           S+ TV + + + ND  P+  P      LP +L V     N    ++  TD D+       
Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753

Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
           YS+  GN NN F  + N GS  T + L           ++ DY  LV V  D  +  R  
Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800

Query: 664 AEALVETGTVTLSIKVI 680
                   T+TL+IKV+
Sbjct: 801 -------STLTLAIKVL 810


>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
          Length = 1682

 Score =  122 bits (306), Expect = 1e-27
 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)

Query: 28   TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
            T   A+N+PP     S+    +++    +   P FPQ++ S  ++EA RV  +       
Sbjct: 587  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 646

Query: 78   -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
                 S TY          F +  TTG+    + LD E+      +          T   
Sbjct: 647  DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 706

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
             + + VTDVN+  P F   L   L   +VE     F+ QV+A DP D   N  + Y L +
Sbjct: 707  TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 763

Query: 177  PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
                FR+++NG++++  +L+ E   R ++ +V V   G +    ++  L + +++++D  
Sbjct: 764  FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 821

Query: 234  PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
            P FT+ T    V E L  GT +  I A+D D     S+ + S   V  +F ++  TG + 
Sbjct: 822  PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 880

Query: 294  VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
            + + +D +A    Q  +I+  V   D  YG     I  +T IV+D+ND P    K  +  
Sbjct: 881  LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 938

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
            MV     KGT +  +    + +D++ P           +   F  P+ +       +   
Sbjct: 939  MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 988

Query: 403  GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
             SG+++   +L+ E P+ +     + +++   D   P   ++  V IL     E P    
Sbjct: 989  DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1042

Query: 463  RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
                   VSE     T VG + A   +    S++YSI +G       + F IN  TG + 
Sbjct: 1043 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1095

Query: 523  LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
            +   +D ET   Y+LR+QA + E           +++  V + I +EN+  P+     Y 
Sbjct: 1096 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1155

Query: 573  LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
              +  D ++ T++   K T  D  + S  ++R  I P       F      G   T +L 
Sbjct: 1156 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1215

Query: 631  -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
               R  Y         +K  V  TDD       KA+ LV     + + + V   P T++
Sbjct: 1216 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1265



 Score =  111 bits (278), Expect = 3e-24
 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)

Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
           PG +Y +    PED  R      F    P++  +S    L      DF   H+ F L+++
Sbjct: 325 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 371

Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
                G  L A   L + I++ N++ P FT P+    +LE    G  ++   N+T+    
Sbjct: 372 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 431

Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
               +D +D   P   L+ +   +  F + Q  +T  + + Q +DR+     +  T +  
Sbjct: 432 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 485

Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
           +   D   G QE+   I  I V D NDN  T  + ++ + V      G  ++ L     D
Sbjct: 486 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 542

Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
           + S         T    VG+   F+ +   +G I +   ++      +  G  Y + +Q 
Sbjct: 543 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 590

Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
            D APP  + N    VY+ +L  P N+ P  F +  Y  ++SE       +  ++ATD++
Sbjct: 591 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 649

Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
               S+ Y+I  G        VF ++  TG L L   +D E+T  YIL I A++   + T
Sbjct: 650 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 703

Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
           S+ TV + + + ND  P+  P      LP +L V     N    ++  TD D+       
Sbjct: 704 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 758

Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
           YS+  GN NN F  + N GS  T + L           ++ DY  LV V  D  +  R  
Sbjct: 759 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 805

Query: 664 AEALVETGTVTLSIKVI 680
                   T+TL+IKV+
Sbjct: 806 -------STLTLAIKVL 815


>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
          Length = 1539

 Score =  122 bits (306), Expect = 1e-27
 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)

Query: 28   TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
            T   A+N+PP     S+    +++    +   P FPQ++ S  ++EA RV  +       
Sbjct: 582  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641

Query: 78   -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
                 S TY          F +  TTG+    + LD E+      +          T   
Sbjct: 642  DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
             + + VTDVN+  P F   L   L   +VE     F+ QV+A DP D   N  + Y L +
Sbjct: 702  TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758

Query: 177  PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
                FR+++NG++++  +L+ E   R ++ +V V   G +    ++  L + +++++D  
Sbjct: 759  FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816

Query: 234  PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
            P FT+ T    V E L  GT +  I A+D D     S+ + S   V  +F ++  TG + 
Sbjct: 817  PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875

Query: 294  VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
            + + +D +A    Q  +I+  V   D  YG     I  +T IV+D+ND P    K  +  
Sbjct: 876  LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
            MV     KGT +  +    + +D++ P           +   F  P+ +       +   
Sbjct: 934  MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983

Query: 403  GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
             SG+++   +L+ E P+ +     + +++   D   P   ++  V IL     E P    
Sbjct: 984  DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037

Query: 463  RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
                   VSE     T VG + A   +    S++YSI +G       + F IN  TG + 
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090

Query: 523  LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
            +   +D ET   Y+LR+QA + E           +++  V + I +EN+  P+     Y 
Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150

Query: 573  LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
              +  D ++ T++   K T  D  + S  ++R  I P       F      G   T +L 
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210

Query: 631  -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
               R  Y         +K  V  TDD       KA+ LV     + + + V   P T++
Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260



 Score =  111 bits (278), Expect = 3e-24
 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)

Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
           PG +Y +    PED  R      F    P++  +S    L      DF   H+ F L+++
Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366

Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
                G  L A   L + I++ N++ P FT P+    +LE    G  ++   N+T+    
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426

Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
               +D +D   P   L+ +   +  F + Q  +T  + + Q +DR+     +  T +  
Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480

Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
           +   D   G QE+   I  I V D NDN  T  + ++ + V      G  ++ L     D
Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537

Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
           + S         T    VG+   F+ +   +G I +   ++      +  G  Y + +Q 
Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585

Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
            D APP  + N    VY+ +L  P N+ P  F +  Y  ++SE       +  ++ATD++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644

Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
               S+ Y+I  G        VF ++  TG L L   +D E+T  YIL I A++   + T
Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698

Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
           S+ TV + + + ND  P+  P      LP +L V     N    ++  TD D+       
Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753

Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
           YS+  GN NN F  + N GS  T + L           ++ DY  LV V  D  +  R  
Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800

Query: 664 AEALVETGTVTLSIKVI 680
                   T+TL+IKV+
Sbjct: 801 -------STLTLAIKVL 810


>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
          Length = 1790

 Score =  122 bits (306), Expect = 1e-27
 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)

Query: 28   TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
            T   A+N+PP     S+    +++    +   P FPQ++ S  ++EA RV  +       
Sbjct: 594  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 653

Query: 78   -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
                 S TY          F +  TTG+    + LD E+      +          T   
Sbjct: 654  DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 713

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
             + + VTDVN+  P F   L   L   +VE     F+ QV+A DP D   N  + Y L +
Sbjct: 714  TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 770

Query: 177  PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
                FR+++NG++++  +L+ E   R ++ +V V   G +    ++  L + +++++D  
Sbjct: 771  FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 828

Query: 234  PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
            P FT+ T    V E L  GT +  I A+D D     S+ + S   V  +F ++  TG + 
Sbjct: 829  PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 887

Query: 294  VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
            + + +D +A    Q  +I+  V   D  YG     I  +T IV+D+ND P    K  +  
Sbjct: 888  LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 945

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
            MV     KGT +  +    + +D++ P           +   F  P+ +       +   
Sbjct: 946  MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 995

Query: 403  GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
             SG+++   +L+ E P+ +     + +++   D   P   ++  V IL     E P    
Sbjct: 996  DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1049

Query: 463  RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
                   VSE     T VG + A   +    S++YSI +G       + F IN  TG + 
Sbjct: 1050 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1102

Query: 523  LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
            +   +D ET   Y+LR+QA + E           +++  V + I +EN+  P+     Y 
Sbjct: 1103 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1162

Query: 573  LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
              +  D ++ T++   K T  D  + S  ++R  I P       F      G   T +L 
Sbjct: 1163 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1222

Query: 631  -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
               R  Y         +K  V  TDD       KA+ LV     + + + V   P T++
Sbjct: 1223 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1272



 Score =  111 bits (277), Expect = 3e-24
 Identities = 146/563 (25%), Positives = 233/563 (41%), Gaps = 97/563 (17%)

Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
           PG +Y +    PED  R      F    P++  +S    L      DF   H+ F L+++
Sbjct: 325 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 371

Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVAN---------I 258
                G  L A   L + I++ N++ P FT P+    +LE    G  +++         I
Sbjct: 372 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 431

Query: 259 TAEDPDDEGFPS--------HLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQN 308
            A D D E  P          L   +   +  F + Q  +T  + + Q +DR+     + 
Sbjct: 432 VALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQ 486

Query: 309 PTISLEVLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDL 367
            T +  +   D   G QE+   I  I V D NDN  T  + ++ + V      G  ++ L
Sbjct: 487 QTYTFSITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 543

Query: 368 NKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKY 427
                D+ S         T    VG+   F+ +   +G I +   ++      +  G  Y
Sbjct: 544 TAVDADEGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTY 591

Query: 428 TVIIQVQDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQV 483
            + +Q  D APP  + N    VY+ +L  P N+ P  F +  Y  ++SE       +  +
Sbjct: 592 ALTVQAADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 650

Query: 484 RATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN 543
           +ATD++    S+ Y+I  G        VF ++  TG L L   +D E+T  YIL I A++
Sbjct: 651 QATDRE--GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASD 704

Query: 544 N--EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSS 598
              + TS+ TV + + + ND  P+  P      LP +L V     N    ++  TD D+ 
Sbjct: 705 GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAG 759

Query: 599 PR-SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNL 657
                 YS+  GN NN F  + N GS  T + L           ++ DY  LV V  D  
Sbjct: 760 INGQVHYSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGA 807

Query: 658 MSDRKKAEALVETGTVTLSIKVI 680
           +  R          T+TL+IKV+
Sbjct: 808 VHPRH--------STLTLAIKVL 822


>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
          Length = 1935

 Score =  122 bits (306), Expect = 1e-27
 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)

Query: 28   TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
            T   A+N+PP     S+    +++    +   P FPQ++ S  ++EA RV  +       
Sbjct: 560  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 619

Query: 78   -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
                 S TY          F +  TTG+    + LD E+      +          T   
Sbjct: 620  DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 679

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
             + + VTDVN+  P F   L   L   +VE     F+ QV+A DP D   N  + Y L +
Sbjct: 680  TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 736

Query: 177  PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
                FR+++NG++++  +L+ E   R ++ +V V   G +    ++  L + +++++D  
Sbjct: 737  FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 794

Query: 234  PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
            P FT+ T    V E L  GT +  I A+D D     S+ + S   V  +F ++  TG + 
Sbjct: 795  PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 853

Query: 294  VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
            + + +D +A    Q  +I+  V   D  YG     I  +T IV+D+ND P    K  +  
Sbjct: 854  LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 911

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
            MV     KGT +  +    + +D++ P           +   F  P+ +       +   
Sbjct: 912  MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 961

Query: 403  GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
             SG+++   +L+ E P+ +     + +++   D   P   ++  V IL     E P    
Sbjct: 962  DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1015

Query: 463  RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
                   VSE     T VG + A   +    S++YSI +G       + F IN  TG + 
Sbjct: 1016 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1068

Query: 523  LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
            +   +D ET   Y+LR+QA + E           +++  V + I +EN+  P+     Y 
Sbjct: 1069 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1128

Query: 573  LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
              +  D ++ T++   K T  D  + S  ++R  I P       F      G   T +L 
Sbjct: 1129 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1188

Query: 631  -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
               R  Y         +K  V  TDD       KA+ LV     + + + V   P T++
Sbjct: 1189 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238



 Score =  111 bits (278), Expect = 3e-24
 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)

Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
           PG +Y +    PED  R      F    P++  +S    L      DF   H+ F L+++
Sbjct: 298 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 344

Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
                G  L A   L + I++ N++ P FT P+    +LE    G  ++   N+T+    
Sbjct: 345 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 404

Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
               +D +D   P   L+ +   +  F + Q  +T  + + Q +DR+     +  T +  
Sbjct: 405 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 458

Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
           +   D   G QE+   I  I V D NDN  T  + ++ + V      G  ++ L     D
Sbjct: 459 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515

Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
           + S         T    VG+   F+ +   +G I +   ++      +  G  Y + +Q 
Sbjct: 516 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 563

Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
            D APP  + N    VY+ +L  P N+ P  F +  Y  ++SE       +  ++ATD++
Sbjct: 564 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 622

Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
               S+ Y+I  G        VF ++  TG L L   +D E+T  YIL I A++   + T
Sbjct: 623 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 676

Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
           S+ TV + + + ND  P+  P      LP +L V     N    ++  TD D+       
Sbjct: 677 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 731

Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
           YS+  GN NN F  + N GS  T + L           ++ DY  LV V  D  +  R  
Sbjct: 732 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 778

Query: 664 AEALVETGTVTLSIKVI 680
                   T+TL+IKV+
Sbjct: 779 -------STLTLAIKVL 788


>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
          Length = 1915

 Score =  122 bits (306), Expect = 1e-27
 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)

Query: 28   TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
            T   A+N+PP     S+    +++    +   P FPQ++ S  ++EA RV  +       
Sbjct: 545  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 604

Query: 78   -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
                 S TY          F +  TTG+    + LD E+      +          T   
Sbjct: 605  DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 664

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
             + + VTDVN+  P F   L   L   +VE     F+ QV+A DP D   N  + Y L +
Sbjct: 665  TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 721

Query: 177  PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
                FR+++NG++++  +L+ E   R ++ +V V   G +    ++  L + +++++D  
Sbjct: 722  FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 779

Query: 234  PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
            P FT+ T    V E L  GT +  I A+D D     S+ + S   V  +F ++  TG + 
Sbjct: 780  PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 838

Query: 294  VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
            + + +D +A    Q  +I+  V   D  YG     I  +T IV+D+ND P    K  +  
Sbjct: 839  LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 896

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
            MV     KGT +  +    + +D++ P           +   F  P+ +       +   
Sbjct: 897  MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 946

Query: 403  GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
             SG+++   +L+ E P+ +     + +++   D   P   ++  V IL     E P    
Sbjct: 947  DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1000

Query: 463  RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
                   VSE     T VG + A   +    S++YSI +G       + F IN  TG + 
Sbjct: 1001 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1053

Query: 523  LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
            +   +D ET   Y+LR+QA + E           +++  V + I +EN+  P+     Y 
Sbjct: 1054 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1113

Query: 573  LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
              +  D ++ T++   K T  D  + S  ++R  I P       F      G   T +L 
Sbjct: 1114 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1173

Query: 631  -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
               R  Y         +K  V  TDD       KA+ LV     + + + V   P T++
Sbjct: 1174 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223



 Score =  111 bits (278), Expect = 3e-24
 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)

Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
           PG +Y +    PED  R      F    P++  +S    L      DF   H+ F L+++
Sbjct: 283 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 329

Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
                G  L A   L + I++ N++ P FT P+    +LE    G  ++   N+T+    
Sbjct: 330 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 389

Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
               +D +D   P   L+ +   +  F + Q  +T  + + Q +DR+     +  T +  
Sbjct: 390 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 443

Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
           +   D   G QE+   I  I V D NDN  T  + ++ + V      G  ++ L     D
Sbjct: 444 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 500

Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
           + S         T    VG+   F+ +   +G I +   ++      +  G  Y + +Q 
Sbjct: 501 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 548

Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
            D APP  + N    VY+ +L  P N+ P  F +  Y  ++SE       +  ++ATD++
Sbjct: 549 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 607

Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
               S+ Y+I  G        VF ++  TG L L   +D E+T  YIL I A++   + T
Sbjct: 608 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 661

Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
           S+ TV + + + ND  P+  P      LP +L V     N    ++  TD D+       
Sbjct: 662 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 716

Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
           YS+  GN NN F  + N GS  T + L           ++ DY  LV V  D  +  R  
Sbjct: 717 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 763

Query: 664 AEALVETGTVTLSIKVI 680
                   T+TL+IKV+
Sbjct: 764 -------STLTLAIKVL 773


>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
          Length = 1952

 Score =  122 bits (306), Expect = 1e-27
 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)

Query: 28   TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
            T   A+N+PP     S+    +++    +   P FPQ++ S  ++EA RV  +       
Sbjct: 582  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641

Query: 78   -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
                 S TY          F +  TTG+    + LD E+      +          T   
Sbjct: 642  DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
             + + VTDVN+  P F   L   L   +VE     F+ QV+A DP D   N  + Y L +
Sbjct: 702  TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758

Query: 177  PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
                FR+++NG++++  +L+ E   R ++ +V V   G +    ++  L + +++++D  
Sbjct: 759  FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816

Query: 234  PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
            P FT+ T    V E L  GT +  I A+D D     S+ + S   V  +F ++  TG + 
Sbjct: 817  PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875

Query: 294  VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
            + + +D +A    Q  +I+  V   D  YG     I  +T IV+D+ND P    K  +  
Sbjct: 876  LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
            MV     KGT +  +    + +D++ P           +   F  P+ +       +   
Sbjct: 934  MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983

Query: 403  GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
             SG+++   +L+ E P+ +     + +++   D   P   ++  V IL     E P    
Sbjct: 984  DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037

Query: 463  RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
                   VSE     T VG + A   +    S++YSI +G       + F IN  TG + 
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090

Query: 523  LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
            +   +D ET   Y+LR+QA + E           +++  V + I +EN+  P+     Y 
Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150

Query: 573  LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
              +  D ++ T++   K T  D  + S  ++R  I P       F      G   T +L 
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210

Query: 631  -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
               R  Y         +K  V  TDD       KA+ LV     + + + V   P T++
Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260



 Score =  111 bits (278), Expect = 3e-24
 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)

Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
           PG +Y +    PED  R      F    P++  +S    L      DF   H+ F L+++
Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366

Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
                G  L A   L + I++ N++ P FT P+    +LE    G  ++   N+T+    
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426

Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
               +D +D   P   L+ +   +  F + Q  +T  + + Q +DR+     +  T +  
Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480

Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
           +   D   G QE+   I  I V D NDN  T  + ++ + V      G  ++ L     D
Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537

Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
           + S         T    VG+   F+ +   +G I +   ++      +  G  Y + +Q 
Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585

Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
            D APP  + N    VY+ +L  P N+ P  F +  Y  ++SE       +  ++ATD++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644

Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
               S+ Y+I  G        VF ++  TG L L   +D E+T  YIL I A++   + T
Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698

Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
           S+ TV + + + ND  P+  P      LP +L V     N    ++  TD D+       
Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753

Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
           YS+  GN NN F  + N GS  T + L           ++ DY  LV V  D  +  R  
Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800

Query: 664 AEALVETGTVTLSIKVI 680
                   T+TL+IKV+
Sbjct: 801 -------STLTLAIKVL 810


>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
          Length = 1957

 Score =  122 bits (306), Expect = 1e-27
 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)

Query: 28   TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
            T   A+N+PP     S+    +++    +   P FPQ++ S  ++EA RV  +       
Sbjct: 582  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641

Query: 78   -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
                 S TY          F +  TTG+    + LD E+      +          T   
Sbjct: 642  DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
             + + VTDVN+  P F   L   L   +VE     F+ QV+A DP D   N  + Y L +
Sbjct: 702  TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 758

Query: 177  PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
                FR+++NG++++  +L+ E   R ++ +V V   G +    ++  L + +++++D  
Sbjct: 759  FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816

Query: 234  PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
            P FT+ T    V E L  GT +  I A+D D     S+ + S   V  +F ++  TG + 
Sbjct: 817  PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 875

Query: 294  VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
            + + +D +A    Q  +I+  V   D  YG     I  +T IV+D+ND P    K  +  
Sbjct: 876  LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
            MV     KGT +  +    + +D++ P           +   F  P+ +       +   
Sbjct: 934  MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 983

Query: 403  GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
             SG+++   +L+ E P+ +     + +++   D   P   ++  V IL     E P    
Sbjct: 984  DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1037

Query: 463  RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
                   VSE     T VG + A   +    S++YSI +G       + F IN  TG + 
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1090

Query: 523  LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
            +   +D ET   Y+LR+QA + E           +++  V + I +EN+  P+     Y 
Sbjct: 1091 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1150

Query: 573  LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
              +  D ++ T++   K T  D  + S  ++R  I P       F      G   T +L 
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1210

Query: 631  -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
               R  Y         +K  V  TDD       KA+ LV     + + + V   P T++
Sbjct: 1211 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260



 Score =  111 bits (278), Expect = 3e-24
 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)

Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
           PG +Y +    PED  R      F    P++  +S    L      DF   H+ F L+++
Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366

Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
                G  L A   L + I++ N++ P FT P+    +LE    G  ++   N+T+    
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426

Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
               +D +D   P   L+ +   +  F + Q  +T  + + Q +DR+     +  T +  
Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480

Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
           +   D   G QE+   I  I V D NDN  T  + ++ + V      G  ++ L     D
Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537

Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
           + S         T    VG+   F+ +   +G I +   ++      +  G  Y + +Q 
Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585

Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
            D APP  + N    VY+ +L  P N+ P  F +  Y  ++SE       +  ++ATD++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644

Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
               S+ Y+I  G        VF ++  TG L L   +D E+T  YIL I A++   + T
Sbjct: 645 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 698

Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
           S+ TV + + + ND  P+  P      LP +L V     N    ++  TD D+       
Sbjct: 699 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753

Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
           YS+  GN NN F  + N GS  T + L           ++ DY  LV V  D  +  R  
Sbjct: 754 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 800

Query: 664 AEALVETGTVTLSIKVI 680
                   T+TL+IKV+
Sbjct: 801 -------STLTLAIKVL 810


>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
          Length = 1962

 Score =  122 bits (306), Expect = 1e-27
 Identities = 175/719 (24%), Positives = 298/719 (41%), Gaps = 99/719 (13%)

Query: 28   TGNVAENSPPG---TSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWL------- 77
            T   A+N+PP     S+    +++    +   P FPQ++ S  ++EA RV  +       
Sbjct: 587  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 646

Query: 78   -----SGTY----------FEVV-TTGM----EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
                 S TY          F +  TTG+    + LD E+      +          T   
Sbjct: 647  DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 706

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLIS 176
             + + VTDVN+  P F   L   L   +VE     F+ QV+A DP D   N  + Y L +
Sbjct: 707  TVNIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGN 763

Query: 177  PPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEV 233
                FR+++NG++++  +L+ E   R ++ +V V   G +    ++  L + +++++D  
Sbjct: 764  FNNLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 821

Query: 234  PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQ 293
            P FT+ T    V E L  GT +  I A+D D     S+ + S   V  +F ++  TG + 
Sbjct: 822  PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELS 880

Query: 294  VAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSI 352
            + + +D +A    Q  +I+  V   D  YG     I  +T IV+D+ND P    K  +  
Sbjct: 881  LLRSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 938

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPA 402
            MV     KGT +  +    + +D++ P           +   F  P+ +       +   
Sbjct: 939  MVAPDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEE 988

Query: 403  GSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFD 462
             SG+++   +L+ E P+ +     + +++   D   P   ++  V IL     E P    
Sbjct: 989  DSGRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 1042

Query: 463  RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
                   VSE     T VG + A   +    S++YSI +G       + F IN  TG + 
Sbjct: 1043 EEYRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIY 1095

Query: 523  LVTKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYF 572
            +   +D ET   Y+LR+QA + E           +++  V + I +EN+  P+     Y 
Sbjct: 1096 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1155

Query: 573  LALPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL 630
              +  D ++ T++   K T  D  + S  ++R  I P       F      G   T +L 
Sbjct: 1156 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1215

Query: 631  -TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
               R  Y         +K  V  TDD       KA+ LV     + + + V   P T++
Sbjct: 1216 HNMRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1265



 Score =  111 bits (278), Expect = 3e-24
 Identities = 145/557 (26%), Positives = 236/557 (42%), Gaps = 92/557 (16%)

Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
           PG +Y +    PED  R      F    P++  +S    L      DF   H+ F L+++
Sbjct: 325 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 371

Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
                G  L A   L + I++ N++ P FT P+    +LE    G  ++   N+T+    
Sbjct: 372 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 431

Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
               +D +D   P   L+ +   +  F + Q  +T  + + Q +DR+     +  T +  
Sbjct: 432 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 485

Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
           +   D   G QE+   I  I V D NDN  T  + ++ + V      G  ++ L     D
Sbjct: 486 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 542

Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
           + S         T    VG+   F+ +   +G I +   ++      +  G  Y + +Q 
Sbjct: 543 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 590

Query: 434 QDVAPPYYKNN----VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD 489
            D APP  + N    VY+ +L  P N+ P  F +  Y  ++SE       +  ++ATD++
Sbjct: 591 ADNAPPAERRNSICTVYIEVLP-PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 649

Query: 490 LPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN--EDT 547
               S+ Y+I  G        VF ++  TG L L   +D E+T  YIL I A++   + T
Sbjct: 650 --GDSITYAIENGDPQ----RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT 703

Query: 548 SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF---KLTCTDLDSSPR-SFR 603
           S+ TV + + + ND  P+  P      LP +L V     N    ++  TD D+       
Sbjct: 704 STATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 758

Query: 604 YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKK 663
           YS+  GN NN F  + N GS  T + L           ++ DY  LV V  D  +  R  
Sbjct: 759 YSL--GNFNNLFRITSN-GSIYTAVKLNR---------EVRDYYELVVVATDGAVHPRH- 805

Query: 664 AEALVETGTVTLSIKVI 680
                   T+TL+IKV+
Sbjct: 806 -------STLTLAIKVL 815


>gi|16933557 dachsous 1 precursor [Homo sapiens]
          Length = 3298

 Score =  122 bits (306), Expect = 1e-27
 Identities = 161/653 (24%), Positives = 269/653 (41%), Gaps = 81/653 (12%)

Query: 5    IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVN 64
            +I++ L G    G         AT  + EN+PPGT +             V P       
Sbjct: 2053 VIIVGLQGEAERGPRFPRASSEAT--IRENAPPGTPI-------------VSPRAVHAGG 2097

Query: 65   SN-PLTEAFRVNWLSGTYFEVVTTGM------EQLDFETGPNIFDLQIYVKDEVGVTDLQ 117
            +N P+T +       GT+    +TG       E LDFE  P +    +   +  G     
Sbjct: 2098 TNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRL--RLVLQAESGGAFAFT 2155

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVE-RANPGFIYQVEAFDPEDTSRNIPLSYFLI 175
            VLT+ + D N+  P+F   L      ++ E R   G + QVEA D +  S    +SY L 
Sbjct: 2156 VLTLTLQDANDNAPRF---LRPHYVAFLPESRPLEGPLLQVEADDLDQGSGG-QISYSLA 2211

Query: 176  SPPKSFRM----SANGTLFSTTELDFEA-GHRSFHLIVEVRDSGGLKASTELQVNIVNLN 230
            +   +  +       GT+ +T  LD E        L+   R S  L  S  L V +++ N
Sbjct: 2212 ASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTN 2271

Query: 231  DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTG 290
            D  P    P  +  V E+   G+ +A +T  D D      ++L S +     F + +  G
Sbjct: 2272 DNRPTIPQPWEL-RVSEDALLGSEIAQVTGNDVDSGPVLWYVL-SPSGPQDPFSVGRYGG 2329

Query: 291  TIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTF 350
             + +   +D       Q     L++L  D P+ G+ N   +T +VEDVNDN     +  +
Sbjct: 2330 RVSLTGPLD-----FEQCDRYQLQLLAHDGPHEGRAN---LTVLVEDVNDNAPAFSQSLY 2381

Query: 351  SIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLI 410
             +M+ E T  G+ +L ++    D DS A N   ++ + S       F  DP       ++
Sbjct: 2382 QVMLLEHTPPGSAILSVS--ATDRDSGA-NGHISYHLAS---PADGFSVDPNNGTLFTIV 2435

Query: 411  GDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDV 470
            G +   +  + A      V+++ +D   P       V++    +N+    F    Y   V
Sbjct: 2436 GTVALGHDGSGAV----DVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAV 2491

Query: 471  SERRPARTRVGQVRATDKDLPQS--SLLYSISTGGASLQYPNVFWINPKTGE-------- 520
            +E  P  + +  + ATD D  +S  ++ YSI +G     +  VF + P+  E        
Sbjct: 2492 TEDLPPGSTLLTLEATDADGSRSHAAVDYSIISG----NWGRVFQLEPRLAEAGESAGPG 2547

Query: 521  ------LQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNSY 571
                  L L+  +D E+   Y L + A +      +S V VTV +L+ ND  P+ T  SY
Sbjct: 2548 PRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASY 2607

Query: 572  FLALPVDLKVGTNIQNFKLTCTDLDSSPRSF-RYSIGPGNVNNHFTFSPNAGS 623
             + +P D  VG  +    +  +D D  P    R+++  G+ +  F    ++G+
Sbjct: 2608 RVTVPEDTPVGAEL--LHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGT 2658



 Score =  121 bits (304), Expect = 3e-27
 Identities = 149/543 (27%), Positives = 232/543 (42%), Gaps = 57/543 (10%)

Query: 119  LTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176
            LTV V DVN+  P F  +L +   + ++E   PG  I  V A D  D+  N  +SY L S
Sbjct: 2362 LTVLVEDVNDNAPAFSQSLYQ---VMLLEHTPPGSAILSVSATD-RDSGANGHISYHLAS 2417

Query: 177  PPKSFRMSAN-GTLFS---TTELDFEAGHRSFHLIVEVRDSG--GLKASTELQVNIVNLN 230
            P   F +  N GTLF+   T  L  + G  +  +++E RD G  G  A   + V + + N
Sbjct: 2418 PADGFSVDPNNGTLFTIVGTVALGHD-GSGAVDVVLEARDHGAPGRAARATVHVQLQDQN 2476

Query: 231  DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS--KYFMIN-- 286
            D  P FT       V E+L PG+ +  + A D D     + + YSI + +  + F +   
Sbjct: 2477 DHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPR 2536

Query: 287  ------------QLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFI 334
                        +  G + + + +D ++  L Q    +L V   DR    Q + + +T  
Sbjct: 2537 LAEAGESAGPGPRALGCLVLLEPLDFES--LTQ---YNLTVAAADRGQPPQSSVVPVTVT 2591

Query: 335  VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSG 394
            V DVNDNP    + ++ + VPE T  G  LL +      D    P+    FT+ SG  SG
Sbjct: 2592 VLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEA---SDADPGPHGLVRFTVSSGDPSG 2648

Query: 395  SRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPE 454
               L +   SG + L   LD E  +      ++ +++Q  D A  ++     V I     
Sbjct: 2649 LFELDE--SSGTLRLAHALDCETQA------RHQLVVQAADPAGAHFA-LAPVTIEVQDV 2699

Query: 455  NEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQ-SSLLYSISTGGASLQYPNVFW 513
            N+    F        V+E +P  T V  + A D D      L YS+   G   +    F 
Sbjct: 2700 NDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFA 2759

Query: 514  INPKTGELQLVTKVDCETTPIYILRIQATNNEDTS-SVTVTVNILEENDEKPICTPNSYF 572
            +N  TGEL+     D E T  + L + A +  + S SVTV+V +  E++  P+    ++ 
Sbjct: 2760 LNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFH 2819

Query: 573  LALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTS 632
              +P   + G ++ + + T  D   +     YS+         T SP  G N T   L  
Sbjct: 2820 FQVPEGARRGHSLGHVQATDED-GGADGLVLYSLA--------TSSPYFGINQTTGALYL 2870

Query: 633  RFD 635
            R D
Sbjct: 2871 RVD 2873



 Score =  108 bits (269), Expect = 3e-23
 Identities = 167/672 (24%), Positives = 263/672 (39%), Gaps = 87/672 (12%)

Query: 33   ENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQL 92
            EN+PPGTS+    + L A+  P +    Q+      +E+F ++  +G     V T +  L
Sbjct: 1660 ENNPPGTSL----LTLRAT-DPDVGANGQVTYGGVSSESFSLDPDTG-----VLTTLRAL 1709

Query: 93   DFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGF 152
            D E    I +L +Y +D      L  +TV+V   +E        +  L L + E  +P  
Sbjct: 1710 DREEQEEI-NLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT 1768

Query: 153  IYQVEAFDPEDTSRNIPLSYFLIS--PPKSFRMS-ANGTLFSTTELDFEAGHRSFHLIVE 209
            +  + A DP D   N  L Y ++   P  +F +  A+G   +   LD E    +F L +E
Sbjct: 1769 LTMLRASDP-DVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREV-EPAFQLRIE 1826

Query: 210  VRDSG--GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEG 267
             RD G   L A+  L V +++ ND  P F  P     V E++  GT++  + A DP D G
Sbjct: 1827 ARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDP-DAG 1885

Query: 268  FPSHLLYSI-TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQ- 325
               H+ Y +    +  F++   +G ++ A  +DR+     Q P+ +  V   D    G  
Sbjct: 1886 ANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDRE-----QCPSYTFSVSAVDGAAAGPL 1940

Query: 326  ENRIQITFIVEDVNDNPATCQKFTFSIMVPE-RTAKGTLLLDLNKFCFDDDSEAPN---- 380
               + +T  V DVND+  T       + +P    +  T  L L     +D     N    
Sbjct: 1941 STTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASIL 2000

Query: 381  NRFNFTMPSGVGSGS-----RFLQDPAGSG---KIVLIGDLDYENPSNLAAGNKYTVIIQ 432
             R   T P G    S     R  + P   G   +++ I   D   P+  A G    +I+ 
Sbjct: 2001 YRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATG---VIIVG 2057

Query: 433  VQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQ 492
            +Q                   E E    F R S    + E  P  T +   RA       
Sbjct: 2058 LQG------------------EAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTN 2099

Query: 493  SSLLYSISTGGASLQYPNVFWINPKTGELQL--VTKVDCETTPIYILRIQATNNEDTSSV 550
              + YSI +G         F I P TG + +     +D E +P   L +QA +    +  
Sbjct: 2100 GPITYSILSGNEK----GTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT 2155

Query: 551  TVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLD-SSPRSFRYSIGPG 609
             +T+ + + ND  P      Y   LP    +   +   ++   DLD  S     YS+   
Sbjct: 2156 VLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPL--LQVEADDLDQGSGGQISYSLAAS 2213

Query: 610  N-VNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALV 668
                  F   P  G+  T  +L           +IW    LV      LM+  + + ALV
Sbjct: 2214 QPARGLFHVDPTTGTITTTAILDR---------EIWAETRLV------LMATDRGSPALV 2258

Query: 669  ETGTVTLSIKVI 680
              G+ TL++ VI
Sbjct: 2259 --GSATLTVMVI 2268



 Score =  106 bits (264), Expect = 1e-22
 Identities = 142/560 (25%), Positives = 225/560 (40%), Gaps = 52/560 (9%)

Query: 33   ENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQL 92
            EN  PG +++ F    +    P      +++   P   A R++  +G       +    L
Sbjct: 1447 ENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-----SAPRGL 1501

Query: 93   DFETGPNIFDLQIYVKDEVGVTDLQVLTVQ----VTDVNE-PPQFQGNLAEGLHLYIVER 147
            D ET P +  L          +  +   V     VTD N+  P F    A    + + E 
Sbjct: 1502 DRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF----ASPSRVRLPED 1557

Query: 148  ANPG-FIYQVEAFDPEDTSRNIPLSYFLISPPKS-FRM-SANGTLFSTTELDFEAGHRSF 204
              PG     V A DP D      +SY L S     FR+ S+ G L     LD E   R+ 
Sbjct: 1558 QPPGPAALHVVARDP-DLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDRE--QRAE 1614

Query: 205  HLIVEVRDSGGL---KASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAE 261
            H++  V    G     A+  L V++ ++NDE P F        + E   PGT +  + A 
Sbjct: 1615 HVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRAT 1674

Query: 262  DPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRP 321
            DP D G    + Y   + S+ F ++  TG +   + +DR+  E      I+L V  +DR 
Sbjct: 1675 DP-DVGANGQVTYGGVS-SESFSLDPDTGVLTTLRALDREEQE-----EINLTVYAQDRG 1727

Query: 322  YGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNN 381
               Q   + +   VED ND+  T      S+ VPE     TL +        D     N 
Sbjct: 1728 SPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM----LRASDPDVGANG 1783

Query: 382  RFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYY 441
            +  + +  G  SG+ F+ D A SG+   +  LD E          + + I+ +D   P  
Sbjct: 1784 QLQYRILDGDPSGA-FVLDLA-SGEFGTMRPLDRE------VEPAFQLRIEARDGGQPAL 1835

Query: 442  KNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL-PQSSLLYSIS 500
               + + +     N+    F  P+Y  +V E  PA T + Q++A D D      + Y + 
Sbjct: 1836 SATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLG 1895

Query: 501  TGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNED----TSSVTVTVNI 556
             G A       F + P +GEL+    +D E  P Y   + A +       +++V+VT+ +
Sbjct: 1896 AGTA-----GAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITV 1950

Query: 557  LEENDEKPICTPNSYFLALP 576
             + ND  P    +   L LP
Sbjct: 1951 RDVNDHAPTFPTSPLRLRLP 1970



 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 136/622 (21%), Positives = 253/622 (40%), Gaps = 64/622 (10%)

Query: 31   VAENSPPGTSVHK-FSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGM 89
            VAEN PPGTSV + F+    +  +  +    Q ++ +  ++AFR++  +G    + T   
Sbjct: 1114 VAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSED--SKAFRIHPQTGEVTTLQTLDR 1171

Query: 90   EQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT--DVNEPP----QFQGNLAEGLHLY 143
            EQ       + + L + V+D          TV V   D+N+      Q  G    GL + 
Sbjct: 1172 EQ------QSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQ 1225

Query: 144  IVERANPG-FIYQVEAFDPEDTSRNIPLSYFLISP-PKSFRMSANGTLFSTTELDFEAGH 201
            + +R  PG  +  ++A DP D   N  + Y L  P  + F +  +     T      A  
Sbjct: 1226 VPDRVPPGTLVTTLQAKDP-DEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAER 1284

Query: 202  RSFHLIVEVRDSGGLKASTELQVNI------------VNLNDEVPRFTSP-TRVYTVLEE 248
              + L +   D G    S  LQ+ +             +L +  P    P     T  E 
Sbjct: 1285 PHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEG 1344

Query: 249  LSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQN 308
            L PG+++ ++ A +P   G  ++ L         F ++  +G + +A+ +D +AG   + 
Sbjct: 1345 LRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRA 1404

Query: 309  PTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLN 368
             T+  E      P G     +++   V+D N++     +   ++ +PE    G  L    
Sbjct: 1405 LTVRAE-----GPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFR 1459

Query: 369  KFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYT 428
                D D   PN+   + +            D A +G +     LD E    L       
Sbjct: 1460 --ASDADGPGPNSDVRYRLLRQEPPVPALRLD-ARTGALSAPRGLDRETTPAL------L 1510

Query: 429  VIIQVQD---VAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRA 485
            ++++  D    A       V   +  + EN+   +F  PS V  + E +P       V A
Sbjct: 1511 LLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRV-RLPEDQPPGPAALHVVA 1569

Query: 486  TDKDLPQSS-LLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN 544
             D DL +++ + Y +++GG        F ++  TG L +V  +D E    ++L + A+++
Sbjct: 1570 RDPDLGEAARVSYRLASGG-----DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDH 1624

Query: 545  ED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS 601
                 +++  +TV++ + NDE P      Y + L  +   GT++   + T  D+ ++ + 
Sbjct: 1625 GSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQ- 1683

Query: 602  FRYSIGPGNVNNH-FTFSPNAG 622
                +  G V++  F+  P+ G
Sbjct: 1684 ----VTYGGVSSESFSLDPDTG 1701



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 142/634 (22%), Positives = 237/634 (37%), Gaps = 70/634 (11%)

Query: 68   LTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQ---VLTVQVT 124
            L      +W S      + T    LD+E  P      I V  + G+  L     ++V + 
Sbjct: 512  LAPGAHTHWFSIDPTSGIITTAASLDYELEPQ--PQLIVVATDGGLPPLASSATVSVALQ 569

Query: 125  DVNE-PPQFQGNLAEGLHLYIVERANPGFIY-QVEAFDPEDTSRNIPLSYFLI------- 175
            DVN+  PQFQ       +  + E   PG  + QV A D +     + LSY L        
Sbjct: 570  DVNDNEPQFQRTF---YNASLPEGTQPGTCFLQVTATDADSGPFGL-LSYSLGAGLGSSG 625

Query: 176  SPPKSFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVP 234
            SPP  FR+ A+ G + +T  LD + G  SF   V   D GGLK+   ++V + + ND  P
Sbjct: 626  SPP--FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPP 683

Query: 235  RFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSK--YFMINQLTGTI 292
            +F       ++  +  PGT V  + A DP D+G    L Y I   +    F +++ +G +
Sbjct: 684  QFYPREYAASISAQSPPGTAVLRLRAHDP-DQGSHGRLSYHILAGNSPPLFTLDEQSGLL 742

Query: 293  QVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSI 352
             VA  + R     R N  + LE+  +D      E   ++   +      P   ++  +  
Sbjct: 743  TVAWPLAR-----RANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVF 797

Query: 353  MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGD 412
             VPE  A GT +  +           P      T+    G         A SG +  +  
Sbjct: 798  SVPEDVAPGTSVGIVQA------HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRP 851

Query: 413  LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472
            LD E       G    + ++     PP +     V +L    N+    F  P     +  
Sbjct: 852  LDRE-----LLGPVLELEVRAGSGVPPAFA-VARVRVLLDDVNDNSPAFPAPEDTVLLPP 905

Query: 473  RRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531
                 T +  +RA D D    S + +++  GG        F ++P TG ++L+  +    
Sbjct: 906  NTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGG-----GAFTVDPTTGHVRLMRPLGPSG 960

Query: 532  TPIYILRIQATNNEDTSSVT-----VTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586
             P + L ++A +       +     V V  +      P     +Y + LP     GT + 
Sbjct: 961  GPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQV- 1019

Query: 587  NFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDY 646
              ++     D  P    Y +     ++ F   P +G    R  L           +++  
Sbjct: 1020 -LQVQAQAPDGGP--ITYHLAAEGASSPFGLEPQSGWLWVRAALDRE------AQELYIL 1070

Query: 647  KLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVI 680
            K++             KAE   +TGT T+ + ++
Sbjct: 1071 KVMAV--------SGSKAELGQQTGTATVRVSIL 1096



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 115/485 (23%), Positives = 188/485 (38%), Gaps = 58/485 (11%)

Query: 153  IYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSA---NGTLFSTTELDFEAGHRSFHLIVE 209
            + QV+A  P+      P++Y L +   S        +G L+    LD EA       ++ 
Sbjct: 1019 VLQVQAQAPDGG----PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMA 1074

Query: 210  VRDS----GGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDD 265
            V  S    G    +  ++V+I+N N+  PR +       V E   PGT V  + A D D 
Sbjct: 1075 VSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDS 1134

Query: 266  --EGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYG 323
               G  ++ L  ++  SK F I+  TG +   Q +DR+     Q  +  L V V+D    
Sbjct: 1135 GPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDRE-----QQSSYQLLVQVQDGGSP 1189

Query: 324  GQENRIQITFIVEDVNDNPATCQKFT------FSIMVPERTAKGTLLLDLNKFCFDDDSE 377
             +     +   V D+NDN  T  + +        I VP+R   GTL+  L      D  E
Sbjct: 1190 PRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQA---KDPDE 1246

Query: 378  APNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVA 437
              N    +T+    G GS        SG+++         P   A    Y + +   D  
Sbjct: 1247 GENGTILYTL---TGPGSELFSLHPHSGELLTAA------PLIRAERPHYVLTLSAHDQG 1297

Query: 438  PPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKD-LPQSSLL 496
             P    ++ + +   P      + + P    D++ER PA      +  T  + L   SLL
Sbjct: 1298 SPPRSASLQLLVQVLPSAR---LAEPPP---DLAERDPAAPVPVVLTVTAAEGLRPGSLL 1351

Query: 497  YSIS----TGGASLQYPNV--------FWINPKTGELQLVTKVDCETTPIY---ILRIQA 541
             S++     G  +L Y  V        F ++  +G L L   +D E  P +    +R + 
Sbjct: 1352 GSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEG 1411

Query: 542  TNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS 601
                    + V V + +EN+  P    +   LALP + + G  +  F+ +  D       
Sbjct: 1412 PGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSD 1471

Query: 602  FRYSI 606
             RY +
Sbjct: 1472 VRYRL 1476



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 163/640 (25%), Positives = 246/640 (38%), Gaps = 81/640 (12%)

Query: 5   IILLALLGAM---SGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQ 61
           ++LL LLGA    + G+A  L L      + E  P GT +   S  L A  +  +  F  
Sbjct: 27  LLLLLLLGAGVPGAWGQAGSLDL-----QIDEEQPAGTLIGDISAGLPAGTAAPLMYFIS 81

Query: 62  IVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTV 121
               + +     ++  SG          EQ D       +       D   V     +TV
Sbjct: 82  AQEGSGVGTDLAIDEHSGVVRTARVLDREQRDR------YRFTAVTPDGATVE----VTV 131

Query: 122 QVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPP-- 178
           +V D+N+  P F    A    L + E    G  Y +E     D  R     Y L      
Sbjct: 132 RVADINDHAPAFPQARAA---LQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAG 188

Query: 179 KSFRMSA----NGT----LFSTTELDFEAGHRSFHLI-VEVRDSGG--LKASTELQVNIV 227
           ++FR+      +GT    L  T ELD E  +RS +++ +E  D G    +A   L V ++
Sbjct: 189 ETFRLETRPGPDGTPVPELVVTGELDRE--NRSHYMLQLEAYDGGSPPRRAQALLDVTLL 246

Query: 228 NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY----F 283
           ++ND  P F        V E L+PG+ V  + A D  D G    + Y I          F
Sbjct: 247 DINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDA-DAGVNGAVTYEINRRQSEGDGPF 305

Query: 284 MINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPA 343
            I+  TG +Q+ + +D       Q     L V  +D     +     +T  V D NDN  
Sbjct: 306 SIDAHTGLLQLERPLD-----FEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQP 360

Query: 344 TCQKFTFSI----MVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQ 399
           +      S      V E    G L+  ++    DD   A     N ++  G G  +   Q
Sbjct: 361 SMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFA---HVNVSLEGGEGHFALSTQ 417

Query: 400 DPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDV-APPYYKNNVYVYILTSPENEFP 458
           D      + +   LD E        + Y + +   D  +PP      +V  +T   +  P
Sbjct: 418 DSV-IYLVCVARRLDREE------RDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAP 470

Query: 459 LIFDRPSYVFDVSERRPARTRVGQ--VRATDKDLPQSS---LLYSISTGGASLQYPNVFW 513
             FDR  Y     E  P     G   VR T +D  Q +   + YS++ G     + + F 
Sbjct: 471 -AFDRQLY---RPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGA----HTHWFS 522

Query: 514 INPKTGELQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNS 570
           I+P +G +     +D E  P   L + AT+       SS TV+V + + ND +P      
Sbjct: 523 IDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTF 582

Query: 571 YFLALPVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGPG 609
           Y  +LP   + GT     ++T TD DS P     YS+G G
Sbjct: 583 YNASLPEGTQPGTCF--LQVTATDADSGPFGLLSYSLGAG 620



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 59/195 (30%), Positives = 89/195 (45%), Gaps = 15/195 (7%)

Query: 116  LQVLTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFL 174
            L  +T++V DVN+  P F  NL   L   + E   PG +         D      L Y L
Sbjct: 2689 LAPVTIEVQDVNDHGPAFPLNL---LSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSL 2745

Query: 175  ISPP------KSFRM-SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIV 227
            +         ++F + S+ G L +    D+E    SF L+V   D+G L AS  + V + 
Sbjct: 2746 LEAGPGPEGREAFALNSSTGELRARVPFDYEHTE-SFRLLVGAADAGNLSASVTVSVLVT 2804

Query: 228  NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQ 287
              ++  P F +P   + V E    G  + ++ A D +D G    +LYS+ T S YF INQ
Sbjct: 2805 GEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATD-EDGGADGLVLYSLATSSPYFGINQ 2863

Query: 288  LTGTIQVAQRIDRDA 302
             TG + +  R+D  A
Sbjct: 2864 TTGALYL--RVDSRA 2876



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 73/288 (25%), Positives = 112/288 (38%), Gaps = 30/288 (10%)

Query: 89   MEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT--DVNE-PPQFQGNLAEGLHLYIV 145
            +E LDFE+    ++L +   D        V+ V VT  DVN+ PP F         + + 
Sbjct: 2557 LEPLDFESLTQ-YNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFT---RASYRVTVP 2612

Query: 146  ERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS---PPKSFRMS-ANGTLFSTTELDFEAG 200
            E    G  +  VEA D +       L  F +S   P   F +  ++GTL     LD E  
Sbjct: 2613 EDTPVGAELLHVEASDADPGPHG--LVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQ 2670

Query: 201  HRSFHLIVEVRDSGGLK-ASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANIT 259
             R   L+V+  D  G   A   + + + ++ND  P F       +V E   PGT+V  + 
Sbjct: 2671 ARH-QLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLH 2729

Query: 260  AEDPDDEGFPSHLLYSITTVS------KYFMINQLTGTIQVAQRIDRDAGELRQNPTISL 313
            A D D   F   L YS+          + F +N  TG ++     D +  E       S 
Sbjct: 2730 AIDGDAGAF-GRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTE-------SF 2781

Query: 314  EVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361
             +LV     G     + ++ +V   ++         F   VPE   +G
Sbjct: 2782 RLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRG 2829



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 92/432 (21%), Positives = 161/432 (37%), Gaps = 55/432 (12%)

Query: 218 ASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDE--GFPSHLLYS 275
           A+ E+ V + ++ND  P F        V E  + GT      A D D    G   + L S
Sbjct: 125 ATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYAL-S 183

Query: 276 ITTVSKYFMINQLTGT-------IQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENR 328
                + F +    G        + V   +DR   E R +  + LE      P    +  
Sbjct: 184 GDGAGETFRLETRPGPDGTPVPELVVTGELDR---ENRSHYMLQLEAYDGGSPPRRAQAL 240

Query: 329 IQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAP-NNRFNFTM 387
           + +T +  D+ND+     +  +  +V E  A G+ +L +    F  D++A  N    + +
Sbjct: 241 LDVTLL--DINDHAPAFNQSRYHAVVSESLAPGSPVLQV----FASDADAGVNGAVTYEI 294

Query: 388 PSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQD--VAPPYYKNNV 445
                 G       A +G + L   LD+E          + +++Q +D    P      V
Sbjct: 295 NRRQSEGDGPFSIDAHTGLLQLERPLDFEQR------RVHELVVQARDGGAHPELGSAFV 348

Query: 446 YVYILTSPENE--FPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGG 503
            V++  + +N+    +IF        VSE  P    V ++  +D D    + +     GG
Sbjct: 349 TVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGG 408

Query: 504 ASLQYPNVFWINPKTGELQLVT---KVDCETTPIYILRIQATNNEDT---SSVTVTVNIL 557
                   F ++ +   + LV    ++D E    Y LR+ AT++      +     +++ 
Sbjct: 409 EGH-----FALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVT 463

Query: 558 EENDEKPICTPNSYF------LALPVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGPGN 610
           + ND  P      Y       +ALP    V       ++T  D D        YS+ PG 
Sbjct: 464 DVNDNAPAFDRQLYRPEPLPEVALPGSFVV-------RVTARDPDQGTNGQVTYSLAPGA 516

Query: 611 VNNHFTFSPNAG 622
             + F+  P +G
Sbjct: 517 HTHWFSIDPTSG 528


>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
          Length = 1886

 Score =  120 bits (302), Expect = 4e-27
 Identities = 173/717 (24%), Positives = 293/717 (40%), Gaps = 85/717 (11%)

Query: 3    EAIILLALLGAMSG--GEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP 60
            +++I L  + A  G  GE  + IL+ A G+             F +  +  L  + PG  
Sbjct: 526  DSVIQLTAVDADEGSNGEITYEILVGAQGD-------------FIINKTTGLITIAPGVE 572

Query: 61   QIVNSN-PLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVL 119
             IV     LT     N         + T  + LD E+      +          T    +
Sbjct: 573  MIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV 632

Query: 120  TVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPP 178
             + VTDVN+  P F   L   L   +VE     F+ QV+A DP D   N  + Y L +  
Sbjct: 633  NIVVTDVNDNAPVFDPYLPRNLS--VVEEEANAFVGQVKATDP-DAGINGQVHYSLGNFN 689

Query: 179  KSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLK---ASTELQVNIVNLNDEVPR 235
              FR+++NG++++  +L+ E   R ++ +V V   G +    ++  L + +++++D  P 
Sbjct: 690  NLFRITSNGSIYTAVKLNREV--RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV 747

Query: 236  FTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVA 295
            FT+ T    V E L  GT +  I A+D D     S+ + S   V  +F ++  TG + + 
Sbjct: 748  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS-PEVKHFFALHPFTGELSLL 806

Query: 296  QRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ-ITFIVEDVNDNPATCQKFTFSIMV 354
            + +D +A    Q  +I+  V   D  YG     I  +T IV+D+ND P    K  +  MV
Sbjct: 807  RSLDYEAFP-DQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 864

Query: 355  PERTAKGTLLLDLNKFCFDDDSEAPN----------NRFNFTMPSGVGSGSRFLQDPAGS 404
                 KGT +  +    + +D++ P           +   F  P+ +       +    S
Sbjct: 865  APDAVKGTPITTV----YAEDADPPGLPASRVRYRVDDVQFPYPASI------FEVEEDS 914

Query: 405  GKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRP 464
            G+++   +L+ E P+ +     + +++   D   P   ++  V IL     E P      
Sbjct: 915  GRVITRVNLN-EEPTTI-----FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEE 968

Query: 465  SYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLV 524
                 VSE     T VG + A   +    S++YSI +G       + F IN  TG + + 
Sbjct: 969  YRPPPVSELATKGTMVGVISAAAIN---QSIVYSIVSGNEE----DTFGINNITGVIYVN 1021

Query: 525  TKVDCETTPIYILRIQATNNE----------DTSSVTVTVNILEENDEKPICTPNSYFLA 574
              +D ET   Y+LR+QA + E           +++  V + I +EN+  P+     Y   
Sbjct: 1022 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1081

Query: 575  LPVDLKVGTNIQNFKLTCTDLDS-SPRSFRYSIGPGNVNNH-FTFSPNAGSNVTRLLL-T 631
            +  D ++ T++   K T  D  + S  ++R  I P       F      G   T +L   
Sbjct: 1082 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHN 1141

Query: 632  SRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVE-TGTVTLSIKVIPHPTTII 687
             R  Y         +K  V  TDD       KA+ LV     + + + V   P T++
Sbjct: 1142 MRRSY---------FKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 129/560 (23%), Positives = 220/560 (39%), Gaps = 105/560 (18%)

Query: 150 PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
           PG +Y +    PED  R      F    P++  +S    L      DF   H+ F L+++
Sbjct: 320 PGILYSILVGTPEDYPR------FFHMHPRTAELS----LLEPVNRDF---HQKFDLVIK 366

Query: 210 VRDSGG--LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVA---NITA---- 260
                G  L A   L + I++ N++ P FT P+    +LE    G  ++   N+T+    
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426

Query: 261 ----EDPDDEGFPSHLLYSITTVSKYFMINQ--LTGTIQVAQRIDRDAGELRQNPTISLE 314
               +D +D   P   L+ +   +  F + Q  +T  + + Q +DR+     +  T +  
Sbjct: 427 VALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE-----EQQTYTFS 480

Query: 315 VLVKDRPYGGQENRIQITFI-VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
           +   D   G QE+   I  I V D NDN  T  + ++ + V      G  ++ L     D
Sbjct: 481 ITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537

Query: 374 DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
           + S         T    VG+   F+ +   +G I +   ++      +  G  Y + +Q 
Sbjct: 538 EGSNG-----EITYEILVGAQGDFIINKT-TGLITIAPGVE------MIVGRTYALTVQA 585

Query: 434 QDVAPPYYKN---------------NVYVYILTSPE------------------NEFPLI 460
            D APP  ++               + Y+ I+T+ +                  N+   +
Sbjct: 586 ADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 645

Query: 461 FD--RPSYVFDVSERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPK 517
           FD   P  +  V E   A   VGQV+ATD D      + YS+        + N+F I   
Sbjct: 646 FDPYLPRNLSVVEEE--ANAFVGQVKATDPDAGINGQVHYSLG------NFNNLFRIT-S 696

Query: 518 TGELQLVTKVDCETTPIYILRIQATN---NEDTSSVTVTVNILEENDEKPICTPNSYFLA 574
            G +    K++ E    Y L + AT+   +   S++T+ + +L+ +D  P+ T ++Y + 
Sbjct: 697 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 756

Query: 575 LPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRF 634
           +  +L  GT I   +    DL +   +  Y I    V + F   P  G     L L    
Sbjct: 757 VEENLPAGTTILQIEAKDVDLGA---NVSYRIRSPEVKHFFALHPFTG----ELSLLRSL 809

Query: 635 DYAGGFDKIWDYKLLVYVTD 654
           DY    D+      LV   D
Sbjct: 810 DYEAFPDQEASITFLVEAFD 829



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 154/693 (22%), Positives = 254/693 (36%), Gaps = 113/693 (16%)

Query: 101  FDLQIYVKDEVG--VTDLQVLTVQVTDVNEP------PQFQGNLAEGLHL--YIVERANP 150
            FDL I  + + G  +     L +++ D N        P +QG + E   +   I +  N 
Sbjct: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420

Query: 151  GFIYQVEAFDPE-DTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVE 209
                ++ A D + + +++  L  FL      F ++  G     T L              
Sbjct: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480

Query: 210  VRDSGGLKASTELQVNI--VNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEG 267
            +    G++ S  + VNI  ++ ND  P F   +    V  ++ PG  V  +TA D  DEG
Sbjct: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA-DEG 539

Query: 268  FPSHLLYSITTVSK-YFMINQLTGTIQVAQRI---------------------DRDAGEL 305
                + Y I   ++  F+IN+ TG I +A  +                     +R  G L
Sbjct: 540  SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGIL 599

Query: 306  RQNPTISLE-----VLV----KDRPYGGQENRIQITFIVEDVNDN-PATCQKFTFSIMVP 355
                 +  E     +L+      RP G     + I  +V DVNDN P        ++ V 
Sbjct: 600  TLGKALDRESTDRYILIITASDGRPDGTSTATVNI--VVTDVNDNAPVFDPYLPRNLSVV 657

Query: 356  ERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDY 415
            E  A        N F     +  P+   N  +   +G+ +          +I   G +  
Sbjct: 658  EEEA--------NAFVGQVKATDPDAGINGQVHYSLGNFNNLF-------RITSNGSIYT 702

Query: 416  ENPSNLAAGNKYTVIIQVQD--VAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473
                N    + Y +++   D  V P +    + + +L   +N    +F   +Y   V E 
Sbjct: 703  AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS--PVFTNSTYTVLVEEN 760

Query: 474  RPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTP 533
             PA T + Q+ A D DL  +++ Y I     S +  + F ++P TGEL L+  +D E  P
Sbjct: 761  LPAGTTILQIEAKDVDL-GANVSYRI----RSPEVKHFFALHPFTGELSLLRSLDYEAFP 815

Query: 534  -------IYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586
                     +              TVTV + + ND  P+ +   Y   +  D   GT I 
Sbjct: 816  DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 875

Query: 587  NFKLTCTDLDSSPRS-FRYSIG------PGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGG 639
                   D    P S  RY +       P ++   F    ++G  +TR+ L         
Sbjct: 876  TVYAEDADPPGLPASRVRYRVDDVQFPYPASI---FEVEEDSGRVITRVNLNE------- 925

Query: 640  FDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQV 699
             +    +KL+V   DD            V + + T+ I V+ HP  I      PR T + 
Sbjct: 926  -EPTTIFKLVVVAFDDG---------EPVMSSSATVKILVL-HPGEI------PRFTQEE 968

Query: 700  LRKNVYSPSAWYVPFVITLGSILLLGLLVYLVV 732
             R    S  A     V  + +  +   +VY +V
Sbjct: 969  YRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1001



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 72/294 (24%), Positives = 114/294 (38%), Gaps = 45/294 (15%)

Query: 330 QITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD----DDSEAPNNRFNF 385
           ++  +V D NDN  T +  ++   V E T  GT +     F  D    D  + PN +  +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDGPNGQIEY 189

Query: 386 TM---PSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYK 442
            +   P    S   F      +G IVL   L+YE+ +      +Y VIIQ  D A    +
Sbjct: 190 VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKT------RYFVIIQANDRAQNLNE 243

Query: 443 NNVYVYILT----SPENEFPLIFD----------RP-SYVFDVSERR-----------PA 476
                  LT      ++  P+             RP +Y   + E R           P 
Sbjct: 244 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 303

Query: 477 RTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYI 536
              + Q R       +  +LYSI  G     YP  F ++P+T EL L+  V+ +    + 
Sbjct: 304 IQAIDQDRNIQPPSDRPGILYSILVGTPE-DYPRFFHMHPRTAELSLLEPVNRDFHQKFD 362

Query: 537 LRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQN 587
           L I+A  +      +   + + IL+EN++ P  T  SY   +     VG  I +
Sbjct: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISD 416


>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
          Length = 4557

 Score =  119 bits (298), Expect = 1e-26
 Identities = 153/600 (25%), Positives = 254/600 (42%), Gaps = 38/600 (6%)

Query: 29   GNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTG 88
            GNV E+ PPG  V   S     +          I   NP    F +  +   +   V   
Sbjct: 2931 GNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGR-FALGLVQSEWKVYVKRP 2989

Query: 89   MEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERA 148
            +++ +     +I+ L I   D + VT   V  V V+DVN+       +A    L     +
Sbjct: 2990 LDREE----QDIYFLNITATDGLFVTQAMV-EVSVSDVNDNSPVCDQVAYTALLPEDIPS 3044

Query: 149  NPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS--FRMSANGTLFSTTELDFEAGHRSFHL 206
            N   I +V A D  D   N  + Y L     S  F    +G L +   LD E     + L
Sbjct: 3045 NK-IILKVSAKDA-DIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRER-IPVYSL 3101

Query: 207  IVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDE 266
            + +  D GG    + + + + ++ND  P F+S      V E  +   ++  + A DPD  
Sbjct: 3102 MAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDI- 3160

Query: 267  GFPSHLLYSIT-TVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQ 325
            G    ++YS+  +    F I+  +G I + Q +DR+     Q  + ++ V   D+  G  
Sbjct: 3161 GINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDRE-----QQSSYNISVRATDQSPGQS 3215

Query: 326  ENRIQ-ITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFN 384
             + +  +T  V D+NDNP   ++  + + VPE T+ GT +L +  F    D    N    
Sbjct: 3216 LSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAV--FATSKDI-GTNAEIT 3272

Query: 385  FTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNN 444
            + + SG   G +F  +P  +G I +   LDYE         ++ ++++ +D   P     
Sbjct: 3273 YLIRSGNEQG-KFKINPK-TGGISVSEVLDYE------LCKRFYLVVEAKDGGTPALSAV 3324

Query: 445  VYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL-PQSSLLYSISTGG 503
              V I  +  N+ P  F +  Y   +SE       V  + A D D  P   + +SI  G 
Sbjct: 3325 ATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGD 3384

Query: 504  ASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEEN 560
                  N F ++P  G +++  K+D E    Y L +QA ++     +S+ TV ++I + N
Sbjct: 3385 RD----NEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVN 3440

Query: 561  DEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPN 620
            D  P+ TP +Y   +  +  VGT+I    +T  D   +   F +SI  GN    F   P+
Sbjct: 3441 DNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH 3500



 Score =  118 bits (296), Expect = 2e-26
 Identities = 112/447 (25%), Positives = 204/447 (45%), Gaps = 37/447 (8%)

Query: 187  GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVL 246
            GT+     LD E     +++ VEV D   + A T++ + +++ ND  P F+ P    T+ 
Sbjct: 1413 GTIVIAKPLDAEQ-RSIYNMSVEVTDGTNV-AVTQVFIKVLDNNDNGPEFSQPNYDVTIS 1470

Query: 247  EELSPGTIVANITAEDPDDEGFPSHLLY-SITTVS-KYFMINQLTGTIQVAQRIDRDAGE 304
            E++ P T +  I A D D++   S+ ++ SI ++S + F I+  TG +  A+R+D +A +
Sbjct: 1471 EDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQD 1530

Query: 305  LRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLL 364
                    L ++V+D+ +  + N  ++   VED ND+        +   V E  A G+ +
Sbjct: 1531 KH-----ILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAV 1585

Query: 365  LDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAG 424
            L +      D  +  N    +T+ +G  +G+ F  +P       ++G +      ++   
Sbjct: 1586 LQVTAL---DKDKGENAELIYTIEAG-NTGNMFKIEP-------VLGIITICKEPDMTTM 1634

Query: 425  NKYTVIIQVQDV-APPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQV 483
             ++ + I+V D  +PP     +    +T  +N  P  F    Y  +V+E     T V  +
Sbjct: 1635 GQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPK-FIHKDYQAEVNENVDIGTSVILI 1693

Query: 484  RATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN 543
             A    + QS+L+Y +  G  +     +F INP +G +     +D E T  Y L IQATN
Sbjct: 1694 SA----ISQSTLIYEVKDGDIN----GIFTINPYSGVITTQKALDYERTSSYQLIIQATN 1745

Query: 544  NED-TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK-----LTCTDLDS 597
                 S+ TV + I++END  P+   + Y  +L     + + +++       +  TD DS
Sbjct: 1746 MAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADS 1805

Query: 598  SPRSFR-YSIGPGNVNNHFTFSPNAGS 623
            +  +   Y I        FT   + G+
Sbjct: 1806 NRNALLVYQIVESTAKKFFTVDSSTGA 1832



 Score =  116 bits (290), Expect = 1e-25
 Identities = 134/523 (25%), Positives = 213/523 (40%), Gaps = 48/523 (9%)

Query: 90   EQLDFETGPNIFDLQIYVKDE---VGVTDLQVLTVQVTDVNE---PPQFQGNLAEGLHLY 143
            ++LD+E     ++L +  KD+   V ++ +  + V+V DVNE    P F      G    
Sbjct: 996  KELDYEK-QQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGS--- 1051

Query: 144  IVERANPGF-IYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEA 199
            + E +  G  + QV A D ED+ R+  + Y +       R S +   G + +   LD E 
Sbjct: 1052 VKENSRIGTSVLQVTARD-EDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRET 1110

Query: 200  GHRSFHLIVEVRDSG--GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVAN 257
               S+ L V   D G   L ++ E+ + + ++ND  P  + P     V+E       V  
Sbjct: 1111 -MGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQ 1169

Query: 258  ITAEDPDDEGFPSHLLYSITTVS--KYFMINQLTGTIQVAQR-IDRDAGELRQNPTISLE 314
            I AEDPD       L Y IT+ +   +F IN  TG I    R +DR+     Q     LE
Sbjct: 1170 IQAEDPDSSS-NEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDRE-----QQAEHFLE 1223

Query: 315  VLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDD 374
            V V D     +++ I +   V D NDN     +  + I +PER  K         F FD 
Sbjct: 1224 VTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDR 1283

Query: 375  DSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQ 434
            D E PN   ++++  G   G  F+    G             +     AG+   + I+  
Sbjct: 1284 D-EGPNAEISYSIVDGNDDGKFFIDPKTGM----------VSSRKQFTAGSYDILTIKAV 1332

Query: 435  DVAPPYYKNNVYVYI---LTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLP 491
            D   P   +   ++I      P +  PL FD P Y F V E       VG V     + P
Sbjct: 1333 DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTP 1392

Query: 492  QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVT 551
                L+    GG    + + F      G + +   +D E   IY + ++ T+  + +   
Sbjct: 1393 ----LWFDIVGG---NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQ 1445

Query: 552  VTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTD 594
            V + +L+ ND  P  +  +Y + +  D+   T I   + T  D
Sbjct: 1446 VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRD 1488



 Score =  108 bits (270), Expect = 2e-23
 Identities = 117/484 (24%), Positives = 209/484 (43%), Gaps = 35/484 (7%)

Query: 118  VLTVQVTDVNEPPQFQGNLAEGLHLYIVER--ANPG-FIYQVEAFDPEDTSRNIPLSYFL 174
            V+ V + D+N+       +  GL  Y   +  A PG  IYQV A D +D   N  ++Y L
Sbjct: 2069 VVRVNIEDIND----NSPVFVGLPYYAAVQVDAEPGTLIYQVTAID-KDKGPNGEVTYVL 2123

Query: 175  ISPPKSFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEV 233
                  F ++ N G +      + +  +  + + +  +D G    ST +++ I  +N  +
Sbjct: 2124 QDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKAM 2183

Query: 234  PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVS--KYFMINQLTGT 291
            P F  P    +V E++   T + +I A  P+ +G    ++Y I      K F I+  TG 
Sbjct: 2184 PVFDKPFYTASVNEDIRMNTPILSINATSPEGQG----IIYIIIDGDPFKQFNIDFDTGV 2239

Query: 292  IQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFS 351
            ++V   +D +           L +   D   G +   + +  +V DVNDNP    + T++
Sbjct: 2240 LKVVSPLDYEV-----TSAYKLTIRASDALTGARAE-VTVDLLVNDVNDNPPIFDQPTYN 2293

Query: 352  IMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIG 411
              + E +  GT +L +     D DSE  N   ++ +     + + +    + SG I+   
Sbjct: 2294 TTLSEASLIGTPVLQV--VSIDADSEN-NKMVHYQIVQDTYNSTDYFHIDSSSGLILTAR 2350

Query: 412  DLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVS 471
             LD+E   +       T+ ++  D   P   + V V+I  S  N+ P +F++  Y   VS
Sbjct: 2351 MLDHELVQHC------TLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVS 2404

Query: 472  ERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCE 530
            E  P    V  V+A+D D      L YSI +G         F ++ K+G + L       
Sbjct: 2405 ELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTS----FLMDSKSGVITLSNHRKQR 2460

Query: 531  TTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKL 590
              P+Y L +  ++   TS+  V + +L  N   P  + ++Y   +  ++  GT + + + 
Sbjct: 2461 MEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRA 2520

Query: 591  TCTD 594
            T  D
Sbjct: 2521 TDGD 2524



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 115/463 (24%), Positives = 195/463 (42%), Gaps = 50/463 (10%)

Query: 185  ANGTLFSTTELDFEAG-----------HRSFHLI-VEVRDSGGLKASTE--LQVNIVNLN 230
            ++G   S   +D E G           H   +L+ + + D G  + S+   L +N+ + N
Sbjct: 766  SDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDAN 825

Query: 231  DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTG 290
            D  P F   +    +LE    GT +  + A D D  G    + YS+ T ++ F IN  TG
Sbjct: 826  DNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD-LGSNGEVTYSVLTDTQQFAINSSTG 884

Query: 291  TIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQE--NRIQITFIVEDVNDNPATCQKF 348
             + VA ++DR++         SL++  +D+   GQ+  + + +   ++DVND        
Sbjct: 885  IVYVADQLDRES-----KANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPS 939

Query: 349  TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408
            ++S+ V E    GT++  L      D       +  +++ +      RF  D A SG I 
Sbjct: 940  SYSVKVLEDLPVGTVIAWLET---HDPDLGLGGQVRYSLVNDY--NGRFEIDKA-SGAIR 993

Query: 409  LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNN---VYVYILTSPENEFPLIFDRPS 465
            L  +LDYE          Y + ++ +D   P   ++   V V ++   EN     F   +
Sbjct: 994  LSKELDYEKQ------QFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFA 1047

Query: 466  YVFDVSERRPARTRVGQVRATDKDLPQ-SSLLYSISTGGASLQYPNVFWINPKTGELQLV 524
             V  V E     T V QV A D+D  +   + YSI  G         F I+ ++G +   
Sbjct: 1048 VVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGL----GRFSIDDESGVITAA 1103

Query: 525  TKVDCETTPIYILRIQATNNEDT---SSVTVTVNILEENDEKPICTPNSYFLALPVDLKV 581
              +D ET   Y L + AT+       S++ V + + + ND  P+ +   Y+   PV ++ 
Sbjct: 1104 DILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY---PVVMEN 1160

Query: 582  G-TNIQNFKLTCTDLDSSP-RSFRYSIGPGNVNNHFTFSPNAG 622
               ++   ++   D DSS      Y I  GN  N F  +   G
Sbjct: 1161 SPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTG 1203



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 120/483 (24%), Positives = 205/483 (42%), Gaps = 37/483 (7%)

Query: 125  DVNE-PPQFQGNLAEGLHLYIVER-ANPGFIYQVEAFDPEDTSRNIPLSYFLI-SPPKSF 181
            DVN+ PP F    ++  +  + E  A    + +V+A DP D   N  + Y L  S    F
Sbjct: 3123 DVNDNPPVFS---SDHYNTCVYENTATKALLTRVQAVDP-DIGINRKVVYSLADSAGGVF 3178

Query: 182  RM-SANGTLFSTTELDFEAGHRSFHLIVEVRDSG---GLKASTELQVNIVNLNDEVPRFT 237
             + S++G +     LD E    S+++ V   D      L + T + + ++++ND  P F 
Sbjct: 3179 SIDSSSGIIILEQPLDREQ-QSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFE 3237

Query: 238  SPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY--FMINQLTGTIQVA 295
                + TV E+ SPGT V  + A   D  G  + + Y I + ++   F IN  TG I V+
Sbjct: 3238 RRDYLVTVPEDTSPGTQVLAVFATSKDI-GTNAEITYLIRSGNEQGKFKINPKTGGISVS 3296

Query: 296  QRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVP 355
            + +D +  +        L V  KD           +   + DVNDNP    +  +S ++ 
Sbjct: 3297 EVLDYELCK-----RFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVIS 3351

Query: 356  ERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDY 415
            E    G  ++ L     +D    PN + +F++ +G    + F  DP   G + +   LD 
Sbjct: 3352 EDALVGDSVILL---IAEDVDSQPNGQIHFSIVNG-DRDNEFTVDPV-LGLVKVKKKLDR 3406

Query: 416  ENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRP 475
            E  S       Y++++Q  D   P   +   V I  S  N+   +F   +Y   + E +P
Sbjct: 3407 ERVSG------YSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKP 3460

Query: 476  ARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIY 535
              T + Q+  TD+D   +   +S S    + +    F ++P  G L+         +  Y
Sbjct: 3461 VGTSILQLVVTDRDSFHNGPPFSFSILSGNEE--EEFVLDPH-GILRSAVVFQHTESLEY 3517

Query: 536  ILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTC 592
            +L +QA ++   +  S   + V ++EE+  KP   P   F+    D   G  I     T 
Sbjct: 3518 VLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATD 3577

Query: 593  TDL 595
             D+
Sbjct: 3578 QDM 3580



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 133/595 (22%), Positives = 241/595 (40%), Gaps = 92/595 (15%)

Query: 62  IVNSNPLTEAFRVN---WLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQV 118
           IV  +PL + F      WL+    E      +Q+D+E+ P  ++L +  KD+        
Sbjct: 303 IVAGDPLDQFFLAKEGKWLN----EYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSA 358

Query: 119 LTV----QVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLS--- 171
           L        T    P +F+  + +   + I E + PG +  +    PE       LS   
Sbjct: 359 LKAVYIGNPTRDTVPIRFEKEVYD---VSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGE 415

Query: 172 ---YFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVN 228
              YF I+P     ++A                +  + +      G LKA  ++ ++I +
Sbjct: 416 DAVYFKINPRSGLIVTAR---------PLNTVKKEVYKLEVTNKEGDLKA--QVTISIED 464

Query: 229 LNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY-FMINQ 287
            ND  P F  P     V E +  GT V  ++A D  D+G   ++ YSI +++   F+INQ
Sbjct: 465 ANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASD-KDKGENGYITYSIASLNLLPFVINQ 523

Query: 288 LTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGG---QENRIQITFIVEDVNDNPAT 344
            TG I   + +D        +P I    +V+   +G     E+ + +T  + +VNDN   
Sbjct: 524 FTGVISTTEELD-----FESSPEI-YRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPL 577

Query: 345 CQKFTFSIMVP-------ERTAKGTLLLD--------------LNKFCFDDDSEAPNNRF 383
            +K     ++          TA   + +D              L  F  + DS     + 
Sbjct: 578 FEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKK 637

Query: 384 NFTMPSGVGSGS----------RFLQDPAGSGKIVLIGDLDYEN----PSNLAAGNKYTV 429
           + T  SG+ +G+            L DP      VL G +  ++     + +A      +
Sbjct: 638 SLT-NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKL 696

Query: 430 IIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDR--PSYVFDVSERRPARTRVGQVRATD 487
           +I+ +       ++    +   + +  +   FD+  PS V  V E  P    + +++A D
Sbjct: 697 LIKAKANGKLNLEDGFLDFYSINRQGPY---FDKSFPSDV-AVKEDLPVGANILKIKAYD 752

Query: 488 KDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRI---QATN 543
            D      +L++IS G       + F I+ +TG+L+++  +D E T +Y+L I      N
Sbjct: 753 ADSGFNGKVLFTISDGNTD----SCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGN 808

Query: 544 NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSS 598
            + +S   +T+N+ + ND  P+   +SY + +     +GT I   +    DL S+
Sbjct: 809 PQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 114/474 (24%), Positives = 190/474 (40%), Gaps = 54/474 (11%)

Query: 167  NIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRS-FHLIVEV-RDSGGLK-ASTELQ 223
            N PL Y +++P   F++ +   +  TT + F+   +  + L+VE  R+   L+ A   ++
Sbjct: 2012 NEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVR 2071

Query: 224  VNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYF 283
            VNI ++ND  P F        V  +  PGT++  +TA D  D+G    + Y +     +F
Sbjct: 2072 VNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAID-KDKGPNGEVTYVLQDDYGHF 2130

Query: 284  MINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPA 343
             IN  +G + + +  + D   +    TI    L KD         +++   +  VN    
Sbjct: 2131 EINPNSGNVILKEAFNSDLSNIEYGVTI----LAKDGGKPSLSTSVELPITI--VNKAMP 2184

Query: 344  TCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVG------SGSRF 397
               K  ++  V E     T +L +N                 T P G G       G  F
Sbjct: 2185 VFDKPFYTASVNEDIRMNTPILSINA----------------TSPEGQGIIYIIIDGDPF 2228

Query: 398  LQ--DPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPEN 455
             Q      +G + ++  LDYE  S       Y + I+  D A    +  V V +L +  N
Sbjct: 2229 KQFNIDFDTGVLKVVSPLDYEVTS------AYKLTIRASD-ALTGARAEVTVDLLVNDVN 2281

Query: 456  EFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWI 514
            + P IFD+P+Y   +SE     T V QV + D D   + ++ Y I     +    + F I
Sbjct: 2282 DNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD--TYNSTDYFHI 2339

Query: 515  NPKTGELQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTP--- 568
            +  +G +     +D E      L++++ ++     +S V V + I + ND  P+      
Sbjct: 2340 DSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIY 2399

Query: 569  NSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAG 622
             SY   L       T +Q      +D D       YSI  GN    F     +G
Sbjct: 2400 ESYVSELAPRGHFVTCVQASDADSSDFD----RLEYSILSGNDRTSFLMDSKSG 2449



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 141/613 (23%), Positives = 243/613 (39%), Gaps = 97/613 (15%)

Query: 83   EVVTTGMEQLDFETGPNIFDLQIYVK--DEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEG 139
            +V+TT  E+LD E  P   D+ I+V+  D  G T    + V V D N+  PQF       
Sbjct: 2551 QVITT--ERLDREN-PLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMT----- 2602

Query: 140  LHLYIVERANPG---FIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELD 196
            +      RA+ G    + QV+A DP+D + N  ++Y L S        A+ ++    E+D
Sbjct: 2603 VEYRASVRADVGRGHLVTQVQAIDPDDGA-NSRITYSLYS-------EASVSVADLLEID 2654

Query: 197  FEAG------------HRSFHLIVEVRDSGGLKASTELQVNIVNLNDE--VPRFTSPTRV 242
             + G            +      V+  D G     + + V I  L  E  +P FT     
Sbjct: 2655 PDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYS 2714

Query: 243  YTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSK--------YFMINQLTGTIQV 294
            +T+ E+ + G+ V  +          PS  ++  T   +         F+I Q TGTI++
Sbjct: 2715 FTIAEDTAIGSTVDTLRI-------LPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKL 2767

Query: 295  AQRIDRD---AGELRQNPTISLEVLVKDRPYGGQENRIQITFIVE------DVNDNPATC 345
             +R+DR+   A   +   TI L+             ++ I F V+      D+NDN    
Sbjct: 2768 DKRLDRETSPAFHFKVAATIPLD-------------KVDIVFTVDVDIKVLDLNDNKPVF 2814

Query: 346  QKFTFSIMVPERTAKGTLLLDLNKFCFD--DDSEAPNNRFNFTMPSGVGSGSRFLQDPAG 403
            +  ++  ++ E    GT L  +     D   + +   +  + + P  V          + 
Sbjct: 2815 ETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNI---DSN 2871

Query: 404  SGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY-YKNNVYVYILTSPENEFPLIFD 462
            +G I  + DLD+E          +T  +   D+   +   +   V +  +  N+   +F 
Sbjct: 2872 TGWISTLKDLDHETDPT------FTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFA 2925

Query: 463  RPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQ 522
            +  Y  +V E  P    V  +   D+D    +   S    G + +      +     ++ 
Sbjct: 2926 QEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVY 2985

Query: 523  LVTKVDCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVG 582
            +   +D E   IY L I AT+    +   V V++ + ND  P+C   +Y   LP D  + 
Sbjct: 2986 VKRPLDREEQDIYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPED--IP 3043

Query: 583  TNIQNFKLTCTDLDSSPRSF-RYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFD 641
            +N    K++  D D     + RYS+  G+ N+ F   P +G   T  LL          +
Sbjct: 3044 SNKIILKVSAKDADIGSNGYIRYSL-YGSGNSEFFLDPESGELKTLALLDR--------E 3094

Query: 642  KIWDYKLLVYVTD 654
            +I  Y L+   TD
Sbjct: 3095 RIPVYSLMAKATD 3107



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 136/580 (23%), Positives = 227/580 (39%), Gaps = 67/580 (11%)

Query: 31   VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90
            V EN   GTSV   S    ++L          V    +   F +N  SG     V T  +
Sbjct: 1680 VNENVDIGTSVILISAISQSTLI-------YEVKDGDINGIFTINPYSG-----VITTQK 1727

Query: 91   QLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPP------QFQGNLAEGLHLYI 144
             LD+E   + + L I   +  G+     + +Q+ D N+        Q+ G+L+E   +  
Sbjct: 1728 ALDYERTSS-YQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINS 1786

Query: 145  VERANPGFIYQVEAFDPEDTSRNIPLSYFLI-SPPKSFRM--SANGTLFSTTELDFEAGH 201
            + R+       + A D  D++RN  L Y ++ S  K F    S+ G + +   LD E   
Sbjct: 1787 IVRSLDNSPLVIRATDA-DSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHET-I 1844

Query: 202  RSFHLIVEVRDSGG--LKASTELQVNI--VNLNDEVPRFTSPTRVYTVLEELSPGTIVAN 257
              FH  V VRDSG   L A + ++VNI   ++ND  P FT       +L     G  V  
Sbjct: 1845 AHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLK 1904

Query: 258  ITAEDPDDEGFPSHLLYSITTVS-KYFMINQLTGTIQVAQRIDRDAGELRQNPTISLE-- 314
            ++A DPD E  P  L YS+   S  +F+I+  +G + +            +N  +S +  
Sbjct: 1905 VSATDPDSE-VPPELTYSLMEGSLDHFLIDSNSGVLTI------------KNNNLSKDHY 1951

Query: 315  VLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDD 374
            +L+     G   +   +T +V++  D+     +  +S  + E     T +  +N      
Sbjct: 1952 MLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVN------ 2005

Query: 375  DSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQ 434
               A  NR N  +   + +     +  + SG I   G      P +      Y ++++  
Sbjct: 2006 ---AVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTG-----VPFDREEQELYELVVEAS 2057

Query: 435  DVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL-PQS 493
                      V V +     N+   +F    Y   V       T + QV A DKD  P  
Sbjct: 2058 RELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNG 2117

Query: 494  SLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPI-YILRIQATNNEDTS-SVT 551
             + Y +            F INP +G + L    + + + I Y + I A +    S S +
Sbjct: 2118 EVTYVLQDDYGH------FEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTS 2171

Query: 552  VTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLT 591
            V + I   N   P+     Y  ++  D+++ T I +   T
Sbjct: 2172 VELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 131/598 (21%), Positives = 228/598 (38%), Gaps = 75/598 (12%)

Query: 105 IYVKDEVGVTDLQVLT---VQVTDVNE------PPQFQGNLAEGLHLYIVERANPGFIYQ 155
           + VK  V   DL+  T   +QV D+N+      P  +   +AE   L          + Q
Sbjct: 127 LIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS-------VAQ 179

Query: 156 VEAFDPEDTSRNIPLSYFLISPPKSFRMS-ANGTLFSTTELDFEAGHRSFHLIVEVRDSG 214
           V A D  D   N    Y+  +    F +   +G +  +  L+++  +R + L +   D G
Sbjct: 180 VTATDA-DIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNR-YDLEILAVDRG 237

Query: 215 -------GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEG 267
                  G+ ++ +L V+I  +N+  P     T V   LE+     +V     +D  +  
Sbjct: 238 MKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGE 297

Query: 268 FPSHLLYSITTVSKYFMINQLTGT----IQVAQRIDRDAGELRQNPTISLEVLVKDRPYG 323
             S  + +   + ++F+  +        I+  ++ID ++     N T+      KD+   
Sbjct: 298 IESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ----AKDKGSP 353

Query: 324 GQENRIQITFIVEDVNDN-PATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNR 382
            + + ++  +I     D  P   +K  + + + E +  G ++  +       D E     
Sbjct: 354 QKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVE----- 408

Query: 383 FNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYK 442
                    G  + + +    SG IV         P N      Y +     +V      
Sbjct: 409 ----YKLSPGEDAVYFKINPRSGLIVTA------RPLNTVKKEVYKL-----EVTNKEGD 453

Query: 443 NNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSIST 501
               V I     N+    F +P Y   V+E  P  T V  V A+DKD  ++  + YSI  
Sbjct: 454 LKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI-- 511

Query: 502 GGASLQYPNVFWINPKTGELQLVTKVDCETTP-IYILRIQATN----NEDTSSVTVTVNI 556
             ASL     F IN  TG +    ++D E++P IY   ++A++        S V VT+ I
Sbjct: 512 --ASLNLLP-FVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRI 568

Query: 557 LEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFT 616
              ND  P+    +    +  D  VG +I    ++  D+D      +Y I  GN    F 
Sbjct: 569 GNVNDNSPLFEKVACQGVISYDFPVGGHIT--AVSAIDIDEL-ELVKYKIISGNELGFFY 625

Query: 617 FSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVT 674
            +P++G    +  LT+     G F       L +  TD   ++D       V  G V+
Sbjct: 626 LNPDSGVLQLKKSLTNSGIKNGNF------ALRITATDGENLADPMSINISVLHGKVS 677


>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
          Length = 4349

 Score =  119 bits (298), Expect = 1e-26
 Identities = 126/459 (27%), Positives = 199/459 (43%), Gaps = 42/459 (9%)

Query: 187  GTLFSTTELDFEAGHRSFHLI-VEVRDSGGLKASTE--LQVNIVNLNDEVPRFTSPTRVY 243
            G L     LD+EA   +F+++ V V D G  + S+   L VN+ + ND  PRF       
Sbjct: 770  GLLTVAAPLDYEA--TNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQL 827

Query: 244  TVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAG 303
            T+ E+   GT +A +T +D D E     + Y++ + ++ F ++ LTG + V   +DR++ 
Sbjct: 828  TISEDTEVGTTIAELTTKDADSED-NGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRES- 885

Query: 304  ELRQNPTISLEVLVKDRPYGGQE--NRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361
                 P   L+V  +D+P  G +  +   +   +EDVNDN   C      + VPE    G
Sbjct: 886  ----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPG 941

Query: 362  TLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNL 421
            T+L  L+     D    P     + +  G     R       +G ++L  +LD+E  +  
Sbjct: 942  TVLTFLDA---SDPDLGPAGEVRYVLMDGAHGTFRV---DLMTGALILERELDFERRAG- 994

Query: 422  AAGNKYTVIIQVQDVAPPYYKN---NVYVYILTSPENEFPLIFDRPSYVFDVSERRPART 478
                 Y + +   D   P  +    +V V +L   EN  P  F    +   V E  P+ T
Sbjct: 995  -----YNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGT 1049

Query: 479  RVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILR 538
            +V  V A D D      L      G  L     F IN  TG +Q +  +D E    Y L 
Sbjct: 1050 QVIVVAAQDDDSGLDGELQYFLRAGTGLA---AFSINQDTGMIQTLAPLDREFASYYWLT 1106

Query: 539  IQATNNEDT--SSVT-VTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDL 595
            + A +      SSVT V + + + ND  P  +   ++ ++  D  VGT++   +L   D 
Sbjct: 1107 VLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSV--LQLDAWDP 1164

Query: 596  DSSPR-SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSR 633
            DSS +    ++I  GN    F   P     VT LL T++
Sbjct: 1165 DSSSKGKLTFNITSGNYMGFFMIHP-----VTGLLSTAQ 1198



 Score =  108 bits (269), Expect = 3e-23
 Identities = 134/513 (26%), Positives = 219/513 (42%), Gaps = 48/513 (9%)

Query: 123  VTDVNE-PPQFQGNLAEGLHLYIVERANPG-FIYQVEAFDPEDTSRNIPLSYFLISP-PK 179
            V DVN+  PQ    L  G    + E   PG FI +V A D  DT  N  ++Y L  P   
Sbjct: 3001 VLDVNDNSPQCSQLLYTGK---VHEDVFPGHFILKVSATDL-DTDTNAQITYSLHGPGAH 3056

Query: 180  SFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTS 238
             F++  + G L + T LD E     F+L+ +  D GG     ++ +++ ++ND  PRF  
Sbjct: 3057 EFKLDPHTGELTTLTALDRERKD-VFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFP 3115

Query: 239  PTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI-TTVSKYFMINQLTGTIQVAQR 297
                  V +  +  T VA + A DP D+G  + ++YS+  +   +F I+  TG I++ + 
Sbjct: 3116 SHCAVAVFDNTTVKTPVAVVFARDP-DQGANAQVVYSLPDSAEGHFSIDATTGVIRLEK- 3173

Query: 298  IDRDAGELRQNPTISLEVLVKDRPYGGQ---ENRIQITFIVEDVNDNPATCQKFTFSIMV 354
                   L+  P   LE+ V+    G          +T  V  + D          S+ V
Sbjct: 3174 ------PLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQV 3227

Query: 355  PERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLD 414
            PE    GT +L L        +     +  + + SG   G RF  D A +G + +   LD
Sbjct: 3228 PEDAPPGTEVLQLATL-----TRPGAEKTGYRVVSGNEQG-RFRLD-ARTGILYVNASLD 3280

Query: 415  YENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERR 474
            +E         KY + I+    +     +   V +  +  NE    F +  Y   V E  
Sbjct: 3281 FE------TSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENA 3334

Query: 475  PARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTP 533
                 +  V ATD+D P  S + YS+  GG  L +   F I+PK GELQ+   +D E   
Sbjct: 3335 LVGDVILTVSATDEDGPLNSDITYSL-IGGNQLGH---FTIHPKKGELQVAKALDREQAS 3390

Query: 534  IYILRIQATN------NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQN 587
             Y L+++AT+      +EDT    + + + + ND  P     +Y   +  +  +G+ +  
Sbjct: 3391 SYSLKLRATDSGQPPLHEDTD---IAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQ 3447

Query: 588  FKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPN 620
              L+  D   +   + + I  GN  + F  +P+
Sbjct: 3448 LILSDPDSPENGPPYSFRITKGNNGSAFRVTPD 3480



 Score =  107 bits (268), Expect = 4e-23
 Identities = 134/519 (25%), Positives = 218/519 (42%), Gaps = 38/519 (7%)

Query: 92   LDFE-TGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVERAN 149
            LD+E T   I ++ +Y       +  ++LTV V D N+  P+F      G  L I E   
Sbjct: 778  LDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPG---GYQLTISEDTE 834

Query: 150  PGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSA-NGTLFSTTELDFEAGHRSFHLIV 208
             G           D+  N  + Y L+SP + F +    G L  T  LD E+  R + L V
Sbjct: 835  VGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEPR-YILKV 893

Query: 209  EVRDSGG----LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPD 264
            E RD       L + T+L + + ++ND  P+  +      V E+L PGT++  + A DPD
Sbjct: 894  EARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPD 953

Query: 265  DEGFPSHLLYSITTVSK-YFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYG 323
              G    + Y +   +   F ++ +TG + + + +D    E R    +SL      RP  
Sbjct: 954  -LGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDF---ERRAGYNLSLWASDGGRPLA 1009

Query: 324  GQENRIQITFIVEDVNDN--PATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNN 381
             +     +  IV DVN+N  P     F     V E +  GT ++ +      DD    + 
Sbjct: 1010 -RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVV---AAQDDDSGLDG 1065

Query: 382  RFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYY 441
               + + +G G  +  +     +G I  +  LD E  S       Y + +   D      
Sbjct: 1066 ELQYFLRAGTGLAAFSINQD--TGMIQTLAPLDREFASY------YWLTVLAVDRGSVPL 1117

Query: 442  KNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLP-QSSLLYSIS 500
             +   VYI  +  N+ P    +  +   + E  P  T V Q+ A D D   +  L ++I+
Sbjct: 1118 SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNIT 1177

Query: 501  TGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNED---TSSVTVTVNIL 557
            +G     Y   F I+P TG L    ++D E    +IL +   +N +    S+  V V IL
Sbjct: 1178 SGN----YMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGIL 1233

Query: 558  EENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLD 596
            + ND  PI +   + + LP  L   +    ++L  +DLD
Sbjct: 1234 DVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLD 1272



 Score =  105 bits (262), Expect = 2e-22
 Identities = 149/616 (24%), Positives = 249/616 (40%), Gaps = 61/616 (9%)

Query: 31   VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90
            V E+ PPGT V  F       L P   G  + V  +     FRV+ ++G           
Sbjct: 934  VPEDLPPGT-VLTFLDASDPDLGPA--GEVRYVLMDGAHGTFRVDLMTGALILE-----R 985

Query: 91   QLDFETGPNIFDLQIYVKD---EVGVTDLQVLTVQVTDVNE---PPQFQGNLAEGLHLYI 144
            +LDFE     ++L ++  D    +    L  + V V DVNE   PP F   + +G    +
Sbjct: 986  ELDFERRAG-YNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQG---QV 1041

Query: 145  VERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEAGH 201
             E +  G    V A   +D+  +  L YFL +       S N   G + +   LD E   
Sbjct: 1042 QENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFAS 1101

Query: 202  RSFHLIVEV-RDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITA 260
              +  ++ V R S  L + TE+ + + + ND  P+ +      ++ E+   GT V  + A
Sbjct: 1102 YYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDA 1161

Query: 261  EDPDDEGFPSHLLYSITTVSK--YFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVK 318
             DPD       L ++IT+ +   +FMI+ +TG +  AQ++DR+  +        LEV V 
Sbjct: 1162 WDPDSSS-KGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEH-----ILEVTVL 1215

Query: 319  DRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEA 378
            D      ++  ++   + DVNDNP       F++ +PER +       + +    D  E 
Sbjct: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSP-VSPGPVYRLVASDLDEG 1274

Query: 379  PNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAP 438
             N R  +++     S          +G +         + S   AG    + I+  D   
Sbjct: 1275 LNGRVTYSIED---SDEEAFSIDLVTGVV--------SSSSTFTAGEYNILTIKATDSGQ 1323

Query: 439  PYYKNNVYVYILTSP---ENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSL 495
            P    +V ++I   P    +  PL FD   Y F V E  P    VG +    +       
Sbjct: 1324 PPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGR---PGLF 1380

Query: 496  LYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVTVTVN 555
             ++IS G   +     F I   TG + +   +D      Y L ++ T+   T +  V + 
Sbjct: 1381 WFNISGGDKDMD----FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIF 1436

Query: 556  ILEE-NDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSI----GPGN 610
            ++   N  +P      Y + +P D   G  ++  ++   D D   +S  Y+I     PG+
Sbjct: 1437 MIANINHHRPQFLETRYEVRVPQDTVPG--VELLRVQAIDQDKG-KSLIYTIHGSQDPGS 1493

Query: 611  VNNHFTFSPNAGSNVT 626
              + F   P++G  VT
Sbjct: 1494 A-SLFQLDPSSGVLVT 1508



 Score =  105 bits (262), Expect = 2e-22
 Identities = 149/611 (24%), Positives = 245/611 (40%), Gaps = 124/611 (20%)

Query: 121  VQVTDVNE-PPQFQG-----NLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFL 174
            V V DVN+ PP F       +++EGL            + Q+ A D +D+ RN  +SY +
Sbjct: 2260 VLVEDVNDNPPTFSQLVYTTSISEGLPAQTP-------VIQLLASD-QDSGRNRDVSYQI 2311

Query: 175  ISP----PKSFRMSAN-GTLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIV 227
            +       K F+++ + G + +  ELD+EA  + FH+ V   D G   L   T + VN+ 
Sbjct: 2312 VEDGSDVSKFFQINGSTGEMSTVQELDYEA-QQHFHVKVRAMDKGDPPLTGETLVVVNVS 2370

Query: 228  NLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITT--VSKYFMI 285
            ++ND  P F  P     V E  + G +V  + A DPD     S L Y I +    ++F I
Sbjct: 2371 DINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRD-TSRLEYLILSGNQDRHFFI 2429

Query: 286  NQLTGTIQVAQ------------RIDRDAG-----------------------------E 304
            N  +G I +              R+    G                             E
Sbjct: 2430 NSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQHLYEAE 2489

Query: 305  LRQNPTIS---LEVLVKDR---PYGGQENRIQITFIVEDVNDNP----ATCQKF------ 348
            L +N  +    +++L  D+   PYG  +  I      E  + NP    AT QK       
Sbjct: 2490 LAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLDRENST 2549

Query: 349  --TFSIMVPERTAKGTLLLDLNKFCFDDDSEAP----NNRFNFTMPSGVGSGSRFLQDPA 402
                +I V  R   G +     K    D+++ P     + +  ++ S V   S  +Q  A
Sbjct: 2550 ERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLA 2609

Query: 403  GSGKIVLIGDLDYE-NPSNLAAG----NKYTVIIQVQDV------------------APP 439
                     D+ Y  NP +L       N  T +++V+D                    PP
Sbjct: 2610 YDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPP 2669

Query: 440  YYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSI 499
            ++ + V V +   P+      F  P Y F   E  P  + +G V+A      Q  ++YS+
Sbjct: 2670 HWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAV---AAQDPVIYSL 2726

Query: 500  STGGA-SLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQA---TNNEDTSSVTVTVN 555
              G         VF ++P TG +++   +D E+T +Y + + A    N +  S V+V + 
Sbjct: 2727 VRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQ 2786

Query: 556  ILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDS---SPRSFRYSIGPG-NV 611
            + + ND +P+   + Y   L  ++ VGT++   ++T  D D+      S+R S  PG NV
Sbjct: 2787 VGDVNDNRPVFEADPYKAVLTENMPVGTSV--IQVTAIDKDTGRDGQVSYRLSADPGSNV 2844

Query: 612  NNHFTFSPNAG 622
            +  F     +G
Sbjct: 2845 HELFAIDSESG 2855



 Score =  102 bits (254), Expect = 2e-21
 Identities = 152/656 (23%), Positives = 264/656 (40%), Gaps = 83/656 (12%)

Query: 34   NSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLD 93
            ++PP  S   F+V+L   LSPV PG    + ++ L E      L+G     VT  +E  D
Sbjct: 1237 DNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEG-----LNGR----VTYSIEDSD 1287

Query: 94   FET-GPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGF 152
             E    ++    +         +  +LT++ TD  +PP    + +  LH+  +    P  
Sbjct: 1288 EEAFSIDLVTGVVSSSSTFTAGEYNILTIKATDSGQPPL---SASVRLHIEWIPWPRPSS 1344

Query: 153  I----------YQVEAFDPEDTSRNI-------PLSYFLIS---PPKSFRMS-ANGTLFS 191
            I          + V   DP +    +        L +F IS       F +    G++  
Sbjct: 1345 IPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVI 1404

Query: 192  TTELDFEAGHRSFHLIVEVRDSGGLKASTELQV-NIVNLNDEVPRFTSPTRVYTVLEELS 250
               LD      +++L VEV D G    +T++ +  I N+N   P+F        V ++  
Sbjct: 1405 ARPLDTRR-RSNYNLTVEVTD-GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTV 1462

Query: 251  PGTIVANITAEDPDDEGFPSHLLYSI-----TTVSKYFMINQLTGTIQVAQRIDRDAGEL 305
            PG  +  + A D D       L+Y+I        +  F ++  +G +    ++D  +G  
Sbjct: 1463 PGVELLRVQAIDQDKG---KSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPS 1519

Query: 306  RQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLL 365
            +     +L V+V+D+    + N + +T  VED N +P    +  +   VP+  A GT LL
Sbjct: 1520 QH----TLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELL 1575

Query: 366  DLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGN 425
             +      D     N   ++++  G   G  F    A  G I L   LD  N +      
Sbjct: 1576 QVRAM---DADRGVNAEVHYSLLKGNSEG--FFNINALLGIITLAQKLDQANHA------ 1624

Query: 426  KYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRA 485
             +T+ ++ +D   P + +   V I   P +    IF +  Y  ++ E  P  + +  V A
Sbjct: 1625 PHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA 1684

Query: 486  TDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNE 545
                +  S + Y +  G        VF +N  +G +    K+D E    Y L+I+ +N  
Sbjct: 1685 ----MSPSEVTYELREGNKD----GVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMA 1736

Query: 546  DT-SSVTVTVNILEENDEKPICTPNSYF----LALPV-DLKVGTNIQNFKLTCTDLDSSP 599
               + V V V+I++END  P+   +++      A P+  + +  N   F +  +D D   
Sbjct: 1737 GAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEA 1796

Query: 600  RSFR-YSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTD 654
             S   Y I        F   P+ G+    L + S  DY    + +  ++  VYV D
Sbjct: 1797 NSLLVYKILEPEALKFFKIDPSMGT----LTIVSEMDY----ESMPSFQFCVYVHD 1844



 Score =  101 bits (251), Expect = 3e-21
 Identities = 122/511 (23%), Positives = 215/511 (42%), Gaps = 56/511 (10%)

Query: 167  NIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFH-LIVEVRDSGGLKASTE--LQ 223
            N  LSYFL++    F M  +  +  T  + F+   +  H L VEVRD+   +   +  ++
Sbjct: 1998 NDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVR 2057

Query: 224  VNIVNLNDEVPRFTSPTRVYTVLEE-LSPGTIVANITAEDPDDEGFPSHLLYSITTVSKY 282
            V+I ++ND  P+F      YT++++   PG ++  ++A D +D G    + Y       Y
Sbjct: 2058 VSIEDVNDNPPKFKH-LPYYTIIQDGTEPGDVLFQVSATD-EDLGTNGAVTYEFAEDYTY 2115

Query: 283  FMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNP 342
            F I+   G I + +  D  A          L+V+ +D      ++  ++   V +   NP
Sbjct: 2116 FRIDPYLGDISLKKPFDYQALN-----KYHLKVIARDGGTPSLQSEEEVLVTVRN-KSNP 2169

Query: 343  ATCQKFTFSIMVPERTAKGTLLLDLN-------KFCFDDDSEAPNNRFNFTMPSGVGSGS 395
                 + + + VPE     T +L          +  ++   E P   F     +GV    
Sbjct: 2170 LFQSPY-YKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGV---- 2224

Query: 396  RFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPEN 455
                       + + G LDYE+ +      K+   ++  D A   + +   V +L    N
Sbjct: 2225 -----------LTVTGPLDYESKT------KHVFTVRATDTALGSF-SEATVEVLVEDVN 2266

Query: 456  EFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQS-SLLYSISTGGASLQYPNVFWI 514
            + P  F +  Y   +SE  PA+T V Q+ A+D+D  ++  + Y I   G+ +     F I
Sbjct: 2267 DNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVS--KFFQI 2324

Query: 515  NPKTGELQLVTKVDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSY 571
            N  TGE+  V ++D E    + ++++A +  D   T    V VN+ + ND  P      Y
Sbjct: 2325 NGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQY 2384

Query: 572  FLALPVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAG----SNVT 626
               +      G  +   K+   D DS   S   Y I  GN + HF  + ++G     N+ 
Sbjct: 2385 EANVSELATCGHLV--LKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLC 2442

Query: 627  RLLLTSRFDY-AGGFDKIWDYKLLVYVTDDN 656
            +  L S ++   G  D ++   + VY+   N
Sbjct: 2443 KKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 142/614 (23%), Positives = 257/614 (41%), Gaps = 55/614 (8%)

Query: 26   PATGNVAENSPPGTSVHKFSV--KLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFE 83
            P    + EN P GTSV + +   K +     V         SN + E F ++  SG    
Sbjct: 2801 PYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSN-VHELFAIDSESGWI-- 2857

Query: 84   VVTTGMEQLDFETGPNI-FDLQIYVKDE-VGVTDLQVLTVQVTDVNE-PPQFQGNLAEGL 140
               T +++LD ET     F +  Y   + + ++   ++ V +TD N+  P+F      G 
Sbjct: 2858 ---TTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGS 2914

Query: 141  HLYIVERANPG-FIYQVEAFDPEDTSRNIPLSYFLIS--PPKSFRMSANGT---LFSTTE 194
               +VE + PG  +  ++  D + + +N  ++ ++    P   F +S  G    + S   
Sbjct: 2915 ---VVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKT 2971

Query: 195  LDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTI 254
            LD E  H + +L+      G  +AS  +++ ++++ND  P+ +       V E++ PG  
Sbjct: 2972 LDRE--HTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHF 3029

Query: 255  VANITAEDPDDEGFPSHLLYSITTVSKY-FMINQLTGTIQVAQRIDRDAGELRQNPTISL 313
            +  ++A D D +   + + YS+     + F ++  TG +     +DR+  ++        
Sbjct: 3030 ILKVSATDLDTDT-NAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDV-------F 3081

Query: 314  EVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFD 373
             ++ K    GG+  +  IT  VEDVNDN         ++ V + T   T +  +  F  D
Sbjct: 3082 NLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVV--FARD 3139

Query: 374  DDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQV 433
             D  A N +  +++P    S        A +G I L      E P  +       + ++ 
Sbjct: 3140 PDQGA-NAQVVYSLPD---SAEGHFSIDATTGVIRL------EKPLQVRPQAPLELTVRA 3189

Query: 434  QDVAPPYYKNNV-YVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQ 492
             D+  P   + +  V +      ++  +F    +   V E  P  T V Q+    +   +
Sbjct: 3190 SDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE 3249

Query: 493  SSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSS--- 549
             +  Y + +G    +    F ++ +TG L +   +D ET+P Y L I+ +    +S    
Sbjct: 3250 KTG-YRVVSGNEQGR----FRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304

Query: 550  VTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS-FRYSIGP 608
             TV VNI + N+ +P    + Y   +  +  VG  I    ++ TD D    S   YS+  
Sbjct: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVI--LTVSATDEDGPLNSDITYSLIG 3362

Query: 609  GNVNNHFTFSPNAG 622
            GN   HFT  P  G
Sbjct: 3363 GNQLGHFTIHPKKG 3376



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 158/713 (22%), Positives = 276/713 (38%), Gaps = 114/713 (15%)

Query: 31   VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90
            ++E SPPG+ V      +   ++P  P    ++  +     F++N  +G    + TT + 
Sbjct: 371  LSEFSPPGSRV------VMVRVTPAFPNLQYVLKPSSENVGFKLNARTGL---ITTTKL- 420

Query: 91   QLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDV----NEPPQFQGNLAEGLHLYIVE 146
             +DF    +    Q++++   G    Q  TV V D+    N  P F  +  +G    + E
Sbjct: 421  -MDFHDRAHY---QLHIRTSPG----QASTVVVIDIVDCNNHAPLFNRSSYDGT---LDE 469

Query: 147  RANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEAGHRS 203
               PG           D   N  ++Y  I+ PK+   S +   G + ++  +D+E   R 
Sbjct: 470  NIPPGTSVLAVTATDRDHGENGYVTYS-IAGPKALPFSIDPYLGIISTSKPMDYELMKRI 528

Query: 204  FHLIVEVRDSGG---LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITA 260
            +   V   D G     +    + + + NLND  P F       ++ ++   G  +  ++A
Sbjct: 529  YTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSA 588

Query: 261  EDPDDEGFPSHLLYSITTVS--KYFMINQLTGTIQVAQR-IDRDAGELRQNPTISLEVLV 317
             D D+     +L Y I + +  +YF +N  +G I + +  I+  AG   Q  + SL++  
Sbjct: 589  IDVDE---LQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAG---QPTSYSLKITA 642

Query: 318  KDRPYGGQENRIQITFIVEDVNDNPATCQK------FTFSIM-----------VPERTAK 360
             D         + IT + +   + P TC K      FT +I+             E T+ 
Sbjct: 643  SDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSL 702

Query: 361  GTLLLDLNKFCFDDD---------------------SEAPNNRFNFTMPSGVGSGSR--F 397
             T  ++     F+D                      +  P+  FN  +   +  G+    
Sbjct: 703  STYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGC 762

Query: 398  LQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEF 457
                  +G + +   LDYE      A N Y + + V D+  P   +   + +     N+ 
Sbjct: 763  FDIELETGLLTVAAPLDYE------ATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDN 816

Query: 458  PLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSS-LLYSISTGGASLQYPNVFWINP 516
               F    Y   +SE     T + ++   D D   +  + Y++      L     F ++P
Sbjct: 817  APRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTL------LSPTEKFSLHP 870

Query: 517  KTGELQLVTKVDCETTPIYILRIQA----TNNEDTSSVTVTVNILEE-NDEKPICTPNSY 571
             TGEL +   +D E+ P YIL+++A    +      SVT  +  LE+ ND  P C     
Sbjct: 871  LTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHN 930

Query: 572  FLALPVDLKVGTNIQNFKLTCTDLDSSPR-SFRYSIGPGNVNNHFTFSPNAGSNVTRLLL 630
             L +P DL  GT +  F L  +D D  P    RY +  G    H TF  +  +    L+L
Sbjct: 931  RLKVPEDLPPGT-VLTF-LDASDPDLGPAGEVRYVLMDG---AHGTFRVDLMTGA--LIL 983

Query: 631  TSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPHP 683
                D    F++   Y L ++ +D      R+    L     + L +    HP
Sbjct: 984  ERELD----FERRAGYNLSLWASDGGRPLARR---TLCHVEVIVLDVNENLHP 1029



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 124/581 (21%), Positives = 243/581 (41%), Gaps = 60/581 (10%)

Query: 74   VNWLSGTYFEVVTTG----MEQLDFETGPN-IFDLQIYVKDEVGVTDLQVLTVQVTDVNE 128
            +N L+   F +   G    +++LD E     +  +++  +D  G      + + +TD N+
Sbjct: 2521 INKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDEND 2580

Query: 129  -PPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFR--MSA 185
             PPQF+ +         V + +P  + QV A+D  D  +N  ++Y  ++P    +  +  
Sbjct: 2581 NPPQFKASEYTVSIQSNVSKDSP--VIQVLAYDA-DEGQNADVTYS-VNPEDLVKDVIEI 2636

Query: 186  NGTLFSTTELDFEAG--HRSFHLIVEVRDSGG--LKASTELQVNIVNLNDEVPRFTSPTR 241
            N         D   G  +++    ++ +D G     +   +++ +V     +P+F+ P  
Sbjct: 2637 NPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLY 2696

Query: 242  VYTVLEELSPGT---IVANITAEDPDDEGFPSHLLYSI-------TTVSKYFMINQLTGT 291
             ++  E+L  G+   IV  + A+DP        ++YS+       +     F ++  TG 
Sbjct: 2697 TFSAPEDLPEGSEIGIVKAVAAQDP--------VIYSLVRGTTPESNKDGVFSLDPDTGV 2748

Query: 292  IQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFS 351
            I+V + +D ++ +L Q     ++V+          + + +   V DVNDN    +   + 
Sbjct: 2749 IKVRKPMDHESTKLYQ-----IDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYK 2803

Query: 352  IMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFL-QDPAGSGKIVLI 410
             ++ E    GT ++ +      D     + + ++ + +  GS    L    + SG I  +
Sbjct: 2804 AVLTENMPVGTSVIQVTAI---DKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTL 2860

Query: 411  GDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDV 470
             +LD E          +  ++           +   V +  + EN+    F    Y   V
Sbjct: 2861 QELDCETCQTY-----HFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSV 2915

Query: 471  SERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPKTGELQLVTK--V 527
             E       V  ++  D D+  Q+  +    T G  L     F I+    E ++ ++  +
Sbjct: 2916 VENSEPGELVATLKTLDADISEQNRQVTCYITEGDPL---GQFGISQVGDEWRISSRKTL 2972

Query: 528  DCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQN 587
            D E T  Y+LR+ A++ +  +SVTV + +L+ ND  P C+   Y   +  D+  G  I  
Sbjct: 2973 DREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFI-- 3030

Query: 588  FKLTCTDLDSSPRS-FRYSI-GPGNVNNHFTFSPNAGSNVT 626
             K++ TDLD+   +   YS+ GPG   + F   P+ G   T
Sbjct: 3031 LKVSATDLDTDTNAQITYSLHGPG--AHEFKLDPHTGELTT 3069



 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 143/619 (23%), Positives = 256/619 (41%), Gaps = 72/619 (11%)

Query: 29   GNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTG 88
            G V ENSP GT V    V      S +       + +     AF +N  +G     +   
Sbjct: 1039 GQVQENSPSGTQV--IVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTG-----MIQT 1091

Query: 89   MEQLDFETGPNIFDLQIYV-KDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVE 146
            +  LD E     +   + V +  V ++ +  + ++VTD N+ PPQ    +    +  I E
Sbjct: 1092 LAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAV---FYPSIQE 1148

Query: 147  RANPG-FIYQVEAFDPEDTSR-----NIP----LSYFLISPPKSFRMSANGTLFSTTELD 196
             A  G  + Q++A+DP+ +S+     NI     + +F+I P         G L +  +LD
Sbjct: 1149 DAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHP-------VTGLLSTAQQLD 1201

Query: 197  FEAGHRSFHLI-VEVRDSG--GLKASTELQVNIVNLNDEVPRFTSP---TRVYTVLEELS 250
             E  ++  H++ V V D+G   LK+++ + V I+++ND  P F+      R+   L  +S
Sbjct: 1202 RE--NKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVS 1259

Query: 251  PGTIVANITAEDPDDEGFPSHLLYSI-TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNP 309
            PG +   + ++   DEG    + YSI  +  + F I+ +TG +  +      AGE     
Sbjct: 1260 PGPVYRLVASD--LDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTF--TAGEYN--- 1312

Query: 310  TISLEVLVKDRPYGGQENRIQITFIV-EDVNDNPATCQKFTFSIMVPERTAKGTLLLDLN 368
             ++++     +P      R+ I +I     +  P    +  +S  V E          +N
Sbjct: 1313 ILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETD-------PVN 1365

Query: 369  KFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYT 428
                    E     F F +  G       ++   GS  IV+   LD    SN      Y 
Sbjct: 1366 HMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGS--IVIARPLDTRRRSN------YN 1417

Query: 429  VIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDK 488
            + ++V D         V+++++ +  +  P  F    Y   V +       + +V+A D+
Sbjct: 1418 LTVEVTD-GSRTIATQVHIFMIANINHHRPQ-FLETRYEVRVPQDTVPGVELLRVQAIDQ 1475

Query: 489  DLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPI-YILRIQATNNE-- 545
            D    SL+Y+I  G       ++F ++P +G L  V K+D  + P  + L +   + E  
Sbjct: 1476 D-KGKSLIYTIH-GSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIP 1533

Query: 546  -DTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRS-FR 603
               + V VT+++ + N   P  T   Y  ++P  +  GT +   ++   D D    +   
Sbjct: 1534 IKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTEL--LQVRAMDADRGVNAEVH 1591

Query: 604  YSIGPGNVNNHFTFSPNAG 622
            YS+  GN    F  +   G
Sbjct: 1592 YSLLKGNSEGFFNINALLG 1610



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 91/410 (22%), Positives = 174/410 (42%), Gaps = 27/410 (6%)

Query: 203 SFHLIVEVRDSG-GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAE 261
           S+ LI++  +    L+A T + V+I++ ND  P F+ P+   T+ E++   + +  +TA 
Sbjct: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTAT 173

Query: 262 DPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRP 321
           D  D G  +   Y+  T S+ F I+  +G + VA +++       +   ++++ + K   
Sbjct: 174 DA-DLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISE 232

Query: 322 YGGQENRIQITFIVED-VNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPN 380
             G  +   +   VE  +   PA            + T   T+L+D N    + +S    
Sbjct: 233 GNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVE-- 290

Query: 381 NRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY 440
                 +    G   + ++  A S +  L+   D      L   + + + +Q +  + PY
Sbjct: 291 -----VVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYL---HGFNLSLQARSGSGPY 342

Query: 441 YKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSIS 500
           + + +  + L  P     L F++  Y   +SE  P  +RV  VR T    P    +   S
Sbjct: 343 FYSQIRGFHL-PPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA-FPNLQYVLKPS 400

Query: 501 TGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVTVTVNILEEN 560
           +          F +N +TG +     +D      Y L I+ +  +  +S  V ++I++ N
Sbjct: 401 SENVG------FKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQ--ASTVVVIDIVDCN 452

Query: 561 DEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSF-RYSI-GP 608
           +  P+   +SY   L  ++  GT++    +T TD D     +  YSI GP
Sbjct: 453 NHAPLFNRSSYDGTLDENIPPGTSV--LAVTATDRDHGENGYVTYSIAGP 500



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 66/241 (27%), Positives = 103/241 (42%), Gaps = 20/241 (8%)

Query: 31   VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGME 90
            V E++PPGT V    ++L+    P        V S      FR++  +G  +   +    
Sbjct: 3227 VPEDAPPGTEV----LQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILYVNAS---- 3278

Query: 91   QLDFETGPNIF-DLQIYVKDEVGVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVERA 148
             LDFET P  F  ++   K    ++D+  + V +TDVNE  PQF     +     ++E A
Sbjct: 3279 -LDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFP---QDPYSTRVLENA 3334

Query: 149  NPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSAN---GTLFSTTELDFEAGHRSFH 205
              G +    +   ED   N  ++Y LI   +    + +   G L     LD E    S+ 
Sbjct: 3335 LVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQA-SSYS 3393

Query: 206  LIVEVRDSG--GLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDP 263
            L +   DSG   L   T++ + + ++ND  PRF       TV E    G+ V  +   DP
Sbjct: 3394 LKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDP 3453

Query: 264  D 264
            D
Sbjct: 3454 D 3454



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 115/539 (21%), Positives = 206/539 (38%), Gaps = 88/539 (16%)

Query: 80   TYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE------PPQFQ 133
            +Y  +++T  ++LD E   + + L+I   +  G     ++ V + D N+         F 
Sbjct: 1707 SYSGLIST-QKKLDHEKISS-YQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFV 1764

Query: 134  GNLAEGLHLY--IVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPP--KSFRMSAN-GT 188
            G ++E   LY  I+++ N  F+      D E  S    L Y ++ P   K F++  + GT
Sbjct: 1765 GQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSL---LVYKILEPEALKFFKIDPSMGT 1821

Query: 189  LFSTTELDFEAGHRSFHLIVEVRDSGG----LKASTELQVNIVNLNDEVPRFTSPTRVYT 244
            L   +E+D+E+   SF   V V D G          ++ +++ ++ND  PRF+       
Sbjct: 1822 LTIVSEMDYES-MPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVA 1880

Query: 245  VLEELSPGTIVANITAEDPDDEGFPSHLLYSITT--VSKYFMINQLTGTIQVAQRIDRDA 302
            ++  + PG  +  + A D D E     + YSI T    +   I+ +TG+I V        
Sbjct: 1881 IVGPIHPGMELLMVRASDEDSE-----VNYSIKTGNADEAVTIHPVTGSISVL------- 1928

Query: 303  GELRQNPTI-----SLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPER 357
                 NP        L +   D  Y   ++   +   +  V D      +  +   V E 
Sbjct: 1929 -----NPAFLGLSRKLTIRASDGLY---QDTALVKISLTQVLDKSLQFDQDVYWAAVKEN 1980

Query: 358  TAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIG---DLD 414
                  L+ L          A  N  N T+   + +G+        +G +   G   D +
Sbjct: 1981 LQDRKALVILG---------AQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDRE 2031

Query: 415  YENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERR 474
             ++   LA        ++V+D   P       V +     N+ P  F    Y   + +  
Sbjct: 2032 QQDTHELA--------VEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGT 2083

Query: 475  PARTRVGQVRATDKDLPQSSLLYSISTGGASLQYP---NVFWINPKTGELQLVTKVDCET 531
                 + QV ATD+DL         + G  + ++      F I+P  G++ L    D + 
Sbjct: 2084 EPGDVLFQVSATDEDLG--------TNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQA 2135

Query: 532  TPIYILRIQATNN-----EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNI 585
               Y L++ A +      +    V VTV     N   P+     Y + +P ++ + T I
Sbjct: 2136 LNKYHLKVIARDGGTPSLQSEEEVLVTV----RNKSNPLFQSPYYKVRVPENITLYTPI 2190



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 32/111 (28%), Positives = 55/111 (49%), Gaps = 10/111 (9%)

Query: 420 NLAAGNKYTVIIQVQDVAPPYYK-NNVYVYILTSPENEFPLIFDRPSYVFDVSERRPART 478
           N    + YT+IIQ  +          V V+IL   +N+   +F  PSY   +SE  P ++
Sbjct: 108 NREVRDSYTLIIQATEKTLELEALTRVVVHILD--QNDLKPLFSPPSYRVTISEDMPLKS 165

Query: 479 RVGQVRATDKDLPQSS-LLYSISTGGASLQYPNVFWINPKTGELQLVTKVD 528
            + +V ATD DL Q++   Y+ +T         +F I+P +G + +  K++
Sbjct: 166 PICKVTATDADLGQNAEFYYAFNTRS------EMFAIHPTSGVVTVAGKLN 210


>gi|9256614 protocadherin beta 3 precursor [Homo sapiens]
          Length = 796

 Score =  118 bits (296), Expect = 2e-26
 Identities = 141/613 (23%), Positives = 244/613 (39%), Gaps = 69/613 (11%)

Query: 2   QEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQ 61
           Q  ++ + L G+++G E+          +VAE    G  +   +  L   +  +     Q
Sbjct: 13  QVLLLFVFLGGSLAGSESRRY-------SVAEEKEKGFLIANLAKDLGLRVEELAARGAQ 65

Query: 62  IVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTV 121
           +V+     + F+++  +G          E+L   T P I   QI +++ +     ++  +
Sbjct: 66  VVSKGN-KQHFQLSHQTGDLLLNEKLDREELCGPTEPCILHFQILLQNPLQFVTNELRII 124

Query: 122 QVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSF 181
            V D + P  F+  +    HL I+E   PG +  +   +  D  RN  L  + I+P   F
Sbjct: 125 DVND-HSPVFFENEM----HLKILESTLPGTVIPLGNAEDLDVGRN-SLQNYTITPNSHF 178

Query: 182 ----RMSANGTLFSTTELDFEAGHRS---FHLIVEVRDSGGLKASTELQVNI--VNLNDE 232
               R   +G  +    LD            L +   D G    S   Q+NI  +++ND 
Sbjct: 179 HVLTRSRRDGRKYPELVLDKALDREEQPELSLTLTALDGGSPPRSGTAQINIQVLDINDN 238

Query: 233 VPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPS---HLLYSITTVSKYFMINQLT 289
            P F  P     VLE     +++  ++A D D   F +      ++   + K F +N +T
Sbjct: 239 APEFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHASEEIRKTFQLNPIT 298

Query: 290 GTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFT 349
           G +Q+ + ++ +A         S EV ++ +  GG   +  +   V DVNDNP      +
Sbjct: 299 GDMQLVKYLNFEAIN-------SYEVDIEAKDGGGLSGKSTVIVQVVDVNDNPPELTLSS 351

Query: 350 FSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVL 409
            +  +PE + +  L +    F   D     N R   ++ + +     F   P+      L
Sbjct: 352 VNSPIPENSGETVLAV----FSVSDLDSGDNGRVMCSIENNLP----FFLKPSVENFYTL 403

Query: 410 I--GDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYV 467
           +  G LD E  S      +Y + I + D+  P  K    + +L S  N+    F + SY 
Sbjct: 404 VSEGALDRETRS------EYNITITITDLGTPRLKTKYNITVLVSDVNDNAPAFTQISYT 457

Query: 468 FDVSERRPARTRVGQVRATDKDL-PQSSLLYS-ISTGGASLQYPNVFWINPKTGELQLVT 525
             V E       +G V ATD+D    + + YS +      L   ++  IN   G L  + 
Sbjct: 458 LFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALR 517

Query: 526 KVDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVG 582
            +D E    +  R+ AT+      +S   V V +L+ ND       NS F+  P      
Sbjct: 518 SLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDAND-------NSPFVLYP------ 564

Query: 583 TNIQNFKLTCTDL 595
             +QN    CT+L
Sbjct: 565 --LQNGSAPCTEL 575


>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
          Length = 799

 Score =  118 bits (296), Expect = 2e-26
 Identities = 157/634 (24%), Positives = 262/634 (41%), Gaps = 78/634 (12%)

Query: 208 VEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDE- 266
           V+   S  L+  +E  + + ++ND  P F +     TV E    GT V N+TA D DD  
Sbjct: 139 VDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPV 198

Query: 267 -GFPSHLLYSITTVSKYFMINQLTGTIQVA-QRIDRDAGELRQNPTISLEVLVKDRPYGG 324
            G  + L+YSI     YF I   T  I+ A   +DR+A   ++   + ++        GG
Sbjct: 199 YGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREA---KEEYLVVIQAKDMGGHSGG 255

Query: 325 QENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFN 384
                 +T  + DVNDNP    +  +   VPE    GT    + +   +D     N + +
Sbjct: 256 LSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTA---IGRVKANDQDIGENAQSS 312

Query: 385 FTMPSGVGSGSRFLQDPAGS--GKIVLIGDLDYENPSNLAAGNKYTVIIQVQDV--APPY 440
           + +  G G+    +   A +  G I L   LD+E   +      YT+ ++  +V   P +
Sbjct: 313 YDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKS------YTLKVEAANVHIDPRF 366

Query: 441 -----YKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSL 495
                +K+   V I+    +E P +F  P+Y+ +V E     + +GQV A D D+  S +
Sbjct: 367 SGRGPFKDTATVKIVVEDADE-PPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPI 425

Query: 496 LYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQAT---NNEDTSSVTV 552
            +SI            F IN   G++ L T +D E +  + + I AT   N+   S V V
Sbjct: 426 RFSID---RHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPV 482

Query: 553 TVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVN 612
            + +L+ ND  P    + Y   L  + K G  IQ       D   +   F YS+ P  VN
Sbjct: 483 AIKVLDVNDNAPEFA-SEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVN 541

Query: 613 N-HFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETG 671
           N +FT   N  ++++ L   + F+      K   Y L + ++D            L  T 
Sbjct: 542 NPNFTIKKNEDNSLSILAKHNGFNR----QKQEVYLLPIIISDSG-------NPPLSSTS 590

Query: 672 TVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLG---SILLLGLLV 728
           T+T+ +    +   + +                 +  A+ +P  +++G   +IL   +L+
Sbjct: 591 TLTIRVCGCSNDGVVQSC----------------NVEAYVLPIGLSMGALIAILACIILL 634

Query: 729 YLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGEAIDPVTGE 788
            ++V+L   + RH         EPL  K +    E +++    +     D EA D  T +
Sbjct: 635 LVIVVLFVTLRRH-------KNEPLIIKDDEDVRE-NIIRYDDEGGGEEDTEAFDIATLQ 686

Query: 789 TYE-FNSKTGARKWKDPLTQMPKWKESSHQGAAP 821
             +  N     +  K  L  MP+      QG AP
Sbjct: 687 NPDGINGFLPRKDIKPDLQFMPR------QGLAP 714



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 88/380 (23%), Positives = 159/380 (41%), Gaps = 38/380 (10%)

Query: 245 VLEELS-PGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAG 303
           VLEE S P  I+      D D        + S       F IN +TG I   +R+DR   
Sbjct: 70  VLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDR--- 126

Query: 304 ELRQNPTISLEVL--VKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKG 361
           E +   T++ + +     +P    E   +    V+D+NDN        +   VPE +  G
Sbjct: 127 EEKAEYTLTAQAVDWETSKPL---EPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILG 183

Query: 362 TLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNL 421
           T + ++     DD     + +  +++  G      F  +P  +     + ++D E     
Sbjct: 184 TSVTNVTATDADDPVYGNSAKLVYSILEG---QPYFSIEPETAIIKTALPNMDRE----- 235

Query: 422 AAGNKYTVIIQVQDVA--PPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTR 479
            A  +Y V+IQ +D+            + +  +  N+ P  F +  Y F V E     T 
Sbjct: 236 -AKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTA 294

Query: 480 VGQVRATDKDLPQSS-LLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILR 538
           +G+V+A D+D+ +++   Y I  G  +  +        + G ++L   +D ET   Y L+
Sbjct: 295 IGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLK 354

Query: 539 IQATN------------NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586
           ++A N             +DT++V +   ++E+ DE P+ +  +Y L +  +  + + I 
Sbjct: 355 VEAANVHIDPRFSGRGPFKDTATVKI---VVEDADEPPVFSSPTYLLEVHENAALNSVIG 411

Query: 587 NFKLTCTDLDSSPRSFRYSI 606
                  D+ SSP   R+SI
Sbjct: 412 QVTARDPDITSSP--IRFSI 429



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 73/251 (29%), Positives = 114/251 (45%), Gaps = 34/251 (13%)

Query: 112 GVTDLQVLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPG-FIYQVEAFDPEDTSRNIP 169
           G++    LTV +TDVN+ PP+F  +L    H  + E    G  I +V+A D +D   N  
Sbjct: 255 GLSGTTTLTVTLTDVNDNPPKFAQSL---YHFSVPEDVVLGTAIGRVKAND-QDIGENAQ 310

Query: 170 LSYFLISPP-------KSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRD---------S 213
            SY +I           S   + +G +     LDFE   +S+ L VE  +          
Sbjct: 311 SSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFET-KKSYTLKVEAANVHIDPRFSGR 369

Query: 214 GGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLL 273
           G  K +  +++ +V   DE P F+SPT +  V E  +  +++  +TA DPD    P  + 
Sbjct: 370 GPFKDTATVKI-VVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSP--IR 426

Query: 274 YSI---TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQ 330
           +SI   T + + F IN   G I +A  +DR+         I+ E+         Q +R+ 
Sbjct: 427 FSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEI-----RNHSQISRVP 481

Query: 331 ITFIVEDVNDN 341
           +   V DVNDN
Sbjct: 482 VAIKVLDVNDN 492



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 108/496 (21%), Positives = 204/496 (41%), Gaps = 56/496 (11%)

Query: 121 VQVTDVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDT--SRNIPLSYFLIS 176
           ++V D+N+  P+F   L    H  + E +  G  +  V A D +D     +  L Y ++ 
Sbjct: 155 IKVQDINDNAPEF---LNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILE 211

Query: 177 PPKSFRMSANGTLFSTT--ELDFEAGHRSFHLIVEVRD----SGGLKASTELQVNIVNLN 230
               F +     +  T    +D EA    + ++++ +D    SGGL  +T L V + ++N
Sbjct: 212 GQPYFSIEPETAIIKTALPNMDREA-KEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVN 270

Query: 231 DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPD-DEGFPSH---------LLYSITTVS 280
           D  P+F      ++V E++  GT +  + A D D  E   S           L+ IT+ +
Sbjct: 271 DNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDA 330

Query: 281 KYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEV--LVKDRPYGGQ---ENRIQITFIV 335
           +        G I++ + +D    E +++ T+ +E   +  D  + G+   ++   +  +V
Sbjct: 331 Q-----AQDGIIRLRKPLD---FETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVV 382

Query: 336 EDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGS 395
           ED  D P      T+ + V E  A  +++  +     D D  +   RF+    + +    
Sbjct: 383 EDA-DEPPVFSSPTYLLEVHENAALNSVIGQVT--ARDPDITSSPIRFSIDRHTDL---E 436

Query: 396 RFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPEN 455
           R     A  GKI L   LD E    L+  +  T+I    ++      + V V I     N
Sbjct: 437 RQFNINADDGKITLATPLDRE----LSVWHNITII--ATEIRNHSQISRVPVAIKVLDVN 490

Query: 456 EFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWIN 515
           +    F      F     +P +  +  V A DKD P++   +  S     +  PN     
Sbjct: 491 DNAPEFASEYEAFLCENGKPGQV-IQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKK 549

Query: 516 PKTGELQLVTK---VDCETTPIYILRI---QATNNEDTSSVTVTVNILEENDEKPICTPN 569
            +   L ++ K    + +   +Y+L I    + N   +S+ T+T+ +   +++  + + N
Sbjct: 550 NEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCN 609

Query: 570 SYFLALPVDLKVGTNI 585
                LP+ L +G  I
Sbjct: 610 VEAYVLPIGLSMGALI 625


>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
            sapiens]
          Length = 2923

 Score =  117 bits (294), Expect = 4e-26
 Identities = 137/552 (24%), Positives = 239/552 (43%), Gaps = 46/552 (8%)

Query: 118  VLTVQVTDVNE-PPQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLI 175
            ++TVQV D+N+  P F   ++      ++E    G+ +  V+A D  D   N  L Y L 
Sbjct: 490  LVTVQVLDINDNAPIF---VSTPFQATVLESVPLGYLVLHVQAIDA-DAGDNARLEYRLA 545

Query: 176  SPPKSFRMSAN-GTLFSTTELDFEAGHRSFHLI-VEVRDSG--GLKASTELQVNIVNLND 231
                 F  + N GT + +   + +     F+   VE RD G   L AS  + V ++++ND
Sbjct: 546  GVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVND 605

Query: 232  EVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGT 291
              P FT P     + E+ + GT V  ++A D D     ++ + S  T +++ + +Q  G 
Sbjct: 606  NNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGG 665

Query: 292  IQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFS 351
            + V+  +  D    RQ       VL      G +++  QI   V D N +    Q   ++
Sbjct: 666  L-VSLALPLDYKLERQ------YVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYT 718

Query: 352  IMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIG 411
            + V E    GT ++ ++     D+    N R  + M   +    +F  D A +G +    
Sbjct: 719  VNVNEDRPAGTTVVLISA---TDEDTGENARITYFMEDSI---PQFRID-ADTGAVTTQA 771

Query: 412  DLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVS 471
            +LDYE+  +      YT+ I  +D   P   +  Y+ IL +  N+    F R SY   V 
Sbjct: 772  ELDYEDQVS------YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825

Query: 472  ERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531
            E  P  T V Q+ ATD+D   +  ++    GG        F +   +G ++ + ++D E 
Sbjct: 826  EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGD--DGDGDFIVESTSGIVRTLRRLDREN 883

Query: 532  TPIYILRIQATNN---EDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNF 588
               Y+LR  A +       + + VTV +L+ ND  P+   + + + +  +  +G  +   
Sbjct: 884  VAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA-- 941

Query: 589  KLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYK 647
            ++T TD D    +   Y I  GN+   F     +G       LT+  D    ++   +Y 
Sbjct: 942  RVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE------LTALVDL--DYEDRPEYV 993

Query: 648  LLVYVTDDNLMS 659
            L++  T   L+S
Sbjct: 994  LVIQATSAPLVS 1005



 Score =  102 bits (255), Expect = 1e-21
 Identities = 97/383 (25%), Positives = 161/383 (42%), Gaps = 23/383 (6%)

Query: 184  SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVY 243
            S  G +     LD++   R + L V   D G  + + ++ VN+ + N   P F S     
Sbjct: 662  SGGGLVSLALPLDYKL-ERQYVLAVTASD-GTRQDTAQIVVNVTDANTHRPVFQSSHYTV 719

Query: 244  TVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAG 303
             V E+   GT V  I+A D +D G  + + Y +      F I+  TG +     +D +  
Sbjct: 720  NVNEDRPAGTTVVLISATD-EDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYE-- 776

Query: 304  ELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTL 363
                  + +L +  +D     + +   +  +V DVNDN     + ++   V E     T 
Sbjct: 777  ---DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTS 833

Query: 364  LLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAA 423
            +L ++     D     N R  +T   G      F+ +   SG +  +  LD EN +    
Sbjct: 834  VLQISA---TDRDSGLNGRVFYTFQGGDDGDGDFIVEST-SGIVRTLRRLDRENVA---- 885

Query: 424  GNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQV 483
              +Y +     D   P  +  + V +     N+ P +F++  +   V E  P    V +V
Sbjct: 886  --QYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARV 943

Query: 484  RATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQAT 542
             ATD D    + ++Y I  G      P VF ++  +GEL  +  +D E  P Y+L IQAT
Sbjct: 944  TATDPDEGTNAQIMYQIVEGNI----PEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT 999

Query: 543  NNEDTSSVTVTVNILEENDEKPI 565
            +    S  TV V +L+ ND  P+
Sbjct: 1000 SAPLVSRATVHVRLLDRNDNPPV 1022



 Score =  100 bits (248), Expect = 8e-21
 Identities = 143/592 (24%), Positives = 235/592 (39%), Gaps = 57/592 (9%)

Query: 31  VAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEV-----V 85
           V EN P GT V        ASL  + P   +        +A   +  S  +F +      
Sbjct: 190 VPENQPAGTPV--------ASLRAIDPDEGEAGRLEYTMDAL-FDSRSNQFFSLDPVTGA 240

Query: 86  TTGMEQLDFET-GPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE--PPQFQGNLAEGLHL 142
            T  E+LD ET   ++F +          + L  LT+ VTD N+  P   Q    E L  
Sbjct: 241 VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLR- 299

Query: 143 YIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLI-----SPPKSFRMSANGTLFSTTELD 196
              E    G+ +  V A D  D   N  + Y L+     SP + F +     +  T    
Sbjct: 300 ---ENLEVGYEVLTVRATDG-DAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355

Query: 197 FEAGHRSFHLIVEV----RDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPG 252
                 S+ L VE     RD G    +  + +++ + ND  P+F+    V  V E+++PG
Sbjct: 356 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415

Query: 253 TIVANITAEDPDDEGFPSHLLYSITT--VSKYFMINQLTGTIQVAQRIDRDAGELRQNPT 310
             V  +TA D  D+G  + + YSI +      F ++  TG + V   +D    E  +  T
Sbjct: 416 APVLRVTASD-RDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDY---ETTKEYT 471

Query: 311 ISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKF 370
           + +      RP     + + +T  V D+NDN        F   V E    G L+L +   
Sbjct: 472 LRVRAQDGGRPPLSNVSGL-VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAI 530

Query: 371 CFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVI 430
              D     N R  + + +GVG    F  +  G+G I +  +LD E        + Y+  
Sbjct: 531 ---DADAGDNARLEYRL-AGVGHDFPFTIN-NGTGWISVAAELDREEV------DFYSFG 579

Query: 431 IQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDL 490
           ++ +D   P    +  V +     N+    F +P Y   ++E     T V  V A D+D 
Sbjct: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD- 638

Query: 491 PQSSLLYSISTGGASLQYPNVFWINPKTGE--LQLVTKVDCETTPIYILRIQATNNEDTS 548
             S + Y I++G       N F I  ++G   + L   +D +    Y+L + A++     
Sbjct: 639 AHSVITYQITSGNTR----NRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQD 694

Query: 549 SVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR 600
           +  + VN+ + N  +P+   + Y + +  D   GT +     T  D   + R
Sbjct: 695 TAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENAR 746



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 101/401 (25%), Positives = 171/401 (42%), Gaps = 31/401 (7%)

Query: 234 PRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTV-----SKYFMINQL 288
           P+F  P+   TV E    GT VA++ A DP DEG    L Y++  +     +++F ++ +
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDP-DEGEAGRLEYTMDALFDSRSNQFFSLDPV 237

Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKF 348
           TG +  A+ +DR+        T    V  +D     +     +T +V D ND+    ++ 
Sbjct: 238 TGAVTTAEELDRET-----KSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQ 292

Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGV-GSGSRFLQDPAGSGKI 407
            +   + E    G  +L +      D    PN    + +  G  GS S   +    SG I
Sbjct: 293 EYKESLRENLEVGYEVLTVRA---TDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVI 349

Query: 408 VLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYV 467
              G +D E   +     + TV    Q   P        V++    +N+    F    YV
Sbjct: 350 RTRGPVDREEVESY----QLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYV 405

Query: 468 FDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTK 526
             V E       V +V A+D+D   ++++ YSI +G A  Q    F+++ +TG L +V+ 
Sbjct: 406 VQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQ----FYLDAQTGALDVVSP 461

Query: 527 VDCETTPIYILRIQATNNE----DTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVG 582
           +D ETT  Y LR++A +         S  VTV +L+ ND  PI     +   +   + +G
Sbjct: 462 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521

Query: 583 TNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGS 623
             + + +    D   + R   Y +    V + F F+ N G+
Sbjct: 522 YLVLHVQAIDADAGDNAR-LEYRL--AGVGHDFPFTINNGT 559



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 96/406 (23%), Positives = 159/406 (39%), Gaps = 45/406 (11%)

Query: 295 AQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMV 354
           A R+   + +L Q P +       +   GG+  R        +VN  P   Q  ++   V
Sbjct: 140 APRLRCQSCKLAQAPGLRAGERSPEESLGGRRKR--------NVNTAPQF-QPPSYQATV 190

Query: 355 PERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSR--FLQDPAGSGKIVLIGD 412
           PE    GT +  L      D  E    R  +TM +   S S   F  DP  +G +    +
Sbjct: 191 PENQPAGTPVASLRAI---DPDEGEAGRLEYTMDALFDSRSNQFFSLDPV-TGAVTTAEE 246

Query: 413 LDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSE 472
           LD E  S       +   +  QD   P       + IL +  N+   +F++  Y   + E
Sbjct: 247 LDRETKST------HVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRE 300

Query: 473 RRPARTRVGQVRATDKDL-PQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCET 531
                  V  VRATD D  P +++LY +  G        VF I+P++G ++    VD E 
Sbjct: 301 NLEVGYEVLTVRATDGDAPPNANILYRLLEGSGG-SPSEVFEIDPRSGVIRTRGPVDREE 359

Query: 532 TPIYILRIQATN-----NEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQ 586
              Y L ++A++        +++  V +++ ++ND  P  +   Y + +  D+  G  + 
Sbjct: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV- 418

Query: 587 NFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWD 645
             ++T +D D    +   YSI  GN    F      G+    L + S  DY    +   +
Sbjct: 419 -LRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGA----LDVVSPLDY----ETTKE 469

Query: 646 YKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPHPTTIITTTP 691
           Y L V   D        +      +G VT+ +  I     I  +TP
Sbjct: 470 YTLRVRAQDGG------RPPLSNVSGLVTVQVLDINDNAPIFVSTP 509


>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
          Length = 801

 Score =  115 bits (289), Expect = 1e-25
 Identities = 130/554 (23%), Positives = 231/554 (41%), Gaps = 75/554 (13%)

Query: 216 LKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDE--GFPSHLL 273
           ++  +E  + I ++ND  P+F     V TV E    GT V  +TA D DD   G  + ++
Sbjct: 145 MEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVV 204

Query: 274 YSITTVSKYFMINQLTGTIQVA-QRIDRDAGELRQNPTISLEVLVKDRPYGGQ----ENR 328
           YSI     YF ++  TG I+ A   +DR+A E         EV+++ +  GGQ       
Sbjct: 205 YSILQGQPYFSVDSKTGVIRTALMNMDREAKEY-------YEVIIQAKDMGGQLGGLAGT 257

Query: 329 IQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMP 388
             +   + DVNDNP    +  + + V E      +   + +    D  E  N    +T+ 
Sbjct: 258 TTVNITLSDVNDNPPRFPQKHYQMSVLE---SAPISSTVGRVFAKDLDEGINAEMKYTIV 314

Query: 389 SGVGSGSRFLQ-DPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY------- 440
            G G+ +  +  DP        +G +  + P +  +   YT  ++V+   P         
Sbjct: 315 DGDGADAFDISTDPN-----FQVGIITVKKPLSFESKKSYT--LKVEGANPHLEMRFLNL 367

Query: 441 --YKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYS 498
             +++   V+I     +E P +F+   Y  +V E     T +  + A D D+  +S+ YS
Sbjct: 368 GPFQDTTTVHISVEDVDE-PPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYS 426

Query: 499 ISTGGASLQYPNVFWINPKTGELQLVTKVDCETTP---IYILRIQATNNEDTSSVTVTVN 555
           I       ++   F+++  TG L     +D E      I +L ++  N     SV VT+ 
Sbjct: 427 IDRSSDPGRF---FYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIK 483

Query: 556 ILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNN-H 614
           +L+ ND  P   P  Y   +  + K G  IQ       D   + + F YS+ P   NN +
Sbjct: 484 VLDVNDNAPE-FPRFYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPN 542

Query: 615 FTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVT 674
           FT   N  +  T  +LT R  +      ++   +L+  +   ++S          TGT+T
Sbjct: 543 FTIRDNQDN--TARILTRRSGFRQQEQSVFHLPILIADSGQPVLS---------STGTLT 591

Query: 675 LSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGSIL-----LLGLLVY 729
           + +        +++                 SP A+ +P  ++ G+++     +  LLV 
Sbjct: 592 IQVCSCDDDGHVMSC----------------SPEAYMLPVSLSRGALIAILACIFVLLVL 635

Query: 730 LVVLLAKAIHRHCP 743
           ++++L+   HR  P
Sbjct: 636 VLLILSMRRHRKQP 649



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 90/341 (26%), Positives = 147/341 (43%), Gaps = 37/341 (10%)

Query: 283 FMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYG-GQENRIQITFIVEDVNDN 341
           F I+  TG I   QR+DR   E R   T+  + L  DR  G   E   +    ++D+NDN
Sbjct: 107 FTIDDTTGDIHAIQRLDR---EERAQYTLRAQAL--DRRTGRPMEPESEFIIKIQDINDN 161

Query: 342 PATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDP 401
                   +   VPE +  GT ++ +     DD +   + R  ++    +  G  +    
Sbjct: 162 EPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYS----ILQGQPYFSVD 217

Query: 402 AGSGKI-VLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPY--YKNNVYVYILTSPENEFP 458
           + +G I   + ++D E      A   Y VIIQ +D+            V I  S  N+ P
Sbjct: 218 SKTGVIRTALMNMDRE------AKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNP 271

Query: 459 LIFDRPSYVFDVSERRPARTRVGQVRATDKDLP-QSSLLYSISTGGASLQYPNVFWINPK 517
             F +  Y   V E  P  + VG+V A D D    + + Y+I  G  +  +      N +
Sbjct: 272 PRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQ 331

Query: 518 TGELQLVTKVDCETTPIYILRIQATNN------------EDTSSVTVTVNILEENDEKPI 565
            G + +   +  E+   Y L+++  N             +DT++V ++V   E+ DE P+
Sbjct: 332 VGIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISV---EDVDEPPV 388

Query: 566 CTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSI 606
             P  YF+ +P D+ +GT IQ   ++  D D +  S RYSI
Sbjct: 389 FEPGFYFVEVPEDVAIGTTIQ--IISAKDPDVTNNSIRYSI 427



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 106/494 (21%), Positives = 204/494 (41%), Gaps = 52/494 (10%)

Query: 121 VQVTDVNE-PPQFQGNLAEGLHLYIVERANP--GFIYQVEAFDPEDTS--RNIPLSYFLI 175
           +++ D+N+  P+F     +G ++  V   +P    + QV A D +D +   +  + Y ++
Sbjct: 153 IKIQDINDNEPKF----LDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSIL 208

Query: 176 SPPKSFRMSANGTLFSTTELDFEAGHRSFH-LIVEVRDSGG----LKASTELQVNIVNLN 230
                F + +   +  T  ++ +   + ++ +I++ +D GG    L  +T + + + ++N
Sbjct: 209 QGQPYFSVDSKTGVIRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVN 268

Query: 231 DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSIT--TVSKYFMI--- 285
           D  PRF       +VLE     + V  + A+D  DEG  + + Y+I     +  F I   
Sbjct: 269 DNPPRFPQKHYQMSVLESAPISSTVGRVFAKDL-DEGINAEMKYTIVDGDGADAFDISTD 327

Query: 286 -NQLTGTIQVAQRIDRDAGELRQNPTISLE-----VLVKDRPYGGQENRIQITFIVEDVN 339
            N   G I V + +   + E +++ T+ +E     + ++    G  ++   +   VEDV+
Sbjct: 328 PNFQVGIITVKKPL---SFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDVD 384

Query: 340 DNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQ 399
           + P     F F + VPE  A GT +  ++      D +  NN   +++      G RF  
Sbjct: 385 EPPVFEPGFYF-VEVPEDVAIGTTIQIISA----KDPDVTNNSIRYSIDRSSDPG-RFFY 438

Query: 400 DPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPL 459
               +G ++    LD E  S       + + +   ++  P    +V V I     N+   
Sbjct: 439 VDITTGALMTARPLDREEFS------WHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAP 492

Query: 460 IFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTG 519
            F R  Y   V E   A   +  V A D+D P++   +  S    +   PN    + +  
Sbjct: 493 EFPR-FYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDN 551

Query: 520 ELQLVTK--------VDCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSY 571
             +++T+              PI I          T ++T+ V   +++     C+P +Y
Sbjct: 552 TARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDDGHVMSCSPEAY 611

Query: 572 FLALPVDLKVGTNI 585
              LPV L  G  I
Sbjct: 612 M--LPVSLSRGALI 623



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 60/261 (22%), Positives = 107/261 (40%), Gaps = 20/261 (7%)

Query: 115 DLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQ-VEAFDPEDTSRNIPLSYF 173
           D   + + V DV+EPP F+        + + E    G   Q + A DP+ T+ +I  S  
Sbjct: 372 DTTTVHISVEDVDEPPVFEPGF---YFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSID 428

Query: 174 LISPPKSFRM--SANGTLFSTTELDFE--AGHRSFHLIVEVRDSGGLKASTELQVNIVNL 229
             S P  F       G L +   LD E  + H    L +E+ +   +  S  + + ++++
Sbjct: 429 RSSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQV-GSVPVTIKVLDV 487

Query: 230 NDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLT 289
           ND  P F      + V E    G ++  ++A D DD     H  YS+   +     N   
Sbjct: 488 NDNAPEFPRFYEAF-VCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEA----ANNPN 542

Query: 290 GTIQ-----VAQRIDRDAGELRQNPTI-SLEVLVKDRPYGGQENRIQITFIVEDVNDNPA 343
            TI+      A+ + R +G  +Q  ++  L +L+ D       +   +T  V   +D+  
Sbjct: 543 FTIRDNQDNTARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDDGH 602

Query: 344 TCQKFTFSIMVPERTAKGTLL 364
                  + M+P   ++G L+
Sbjct: 603 VMSCSPEAYMLPVSLSRGALI 623


>gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precursor
           [Homo sapiens]
          Length = 837

 Score =  115 bits (287), Expect = 2e-25
 Identities = 140/602 (23%), Positives = 246/602 (40%), Gaps = 59/602 (9%)

Query: 5   IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVN 64
           ++L   LG + G  A  +       +V E +  G+ V   S  L      +     +IV 
Sbjct: 15  LLLCIFLGTLRGFRARQIRY-----SVPEETEKGSFVGNISKDLGLEPRELAKRGVRIV- 68

Query: 65  SNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT 124
           S   T+ F VN  SG+         E+L         ++++ V+D + +  ++V  + + 
Sbjct: 69  SRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDIN 128

Query: 125 DVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMS 184
           D    P FQ +  E   + + E A PG  + +      D   N   SY L SP   F + 
Sbjct: 129 D--NAPSFQEDEVE---IKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-SPNNYFSLQ 182

Query: 185 ANG----------TLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDE 232
             G           L  + + + EA H    L++   D G    K +  ++V ++++ND 
Sbjct: 183 LRGRTDGAKNPELVLEGSLDREKEAAHL---LLLTALDGGDPIRKGAVPIRVVVLDVNDH 239

Query: 233 VPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI----TTVSKYFMINQL 288
           +P FT      +V E +S GT V  + A DP DEG    ++YS     +  S+ F ++  
Sbjct: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDP-DEGINGEVMYSFRNMESKASEIFQLDSQ 298

Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKF 348
           TG +QV   +D +            E+ ++ +  GG      +   V DVNDN       
Sbjct: 299 TGEVQVRGSLDFEKYRF-------YEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITIT 351

Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408
           +    + E +  GT++  LN     D     N + +  +P+ +    +  +      K++
Sbjct: 352 SSINSILENSPPGTVIALLN---VQDQDSGENGQVSCFIPNHL--PFKLEKTYGNYYKLI 406

Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468
               LD E          Y + +   D   P      +V++  + +N+ P +F   SY  
Sbjct: 407 TSRVLDRE------LVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA 460

Query: 469 DVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGA-SLQYPNVFWINPKTGELQLVTK 526
            + E  P    +  V A D D  Q++L+ YS++      +   +   IN  TG L  +  
Sbjct: 461 YIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS 520

Query: 527 VDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGT 583
            D E      LR+ A ++ D   +S+V++++ +L++ND      P   + ALP D   G 
Sbjct: 521 FDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDN----APEILYPALPTDGSTGV 576

Query: 584 NI 585
            +
Sbjct: 577 EL 578



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 101/428 (23%), Positives = 182/428 (42%), Gaps = 52/428 (12%)

Query: 119 LTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176
           + V V DVN+  P F  ++     + + E  + G  +  V A DP++      +  F   
Sbjct: 229 IRVVVLDVNDHIPMFTQSV---YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNM 285

Query: 177 PPKSFRM----SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDE 232
             K+  +    S  G +     LDFE  +R + + ++ +D GGL  +T + + +V++ND 
Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEK-YRFYEMEIQGQDGGGLFTTTTMLITVVDVNDN 344

Query: 233 VPRFTSPTRVYTVLEELSPGTIVA--NITAEDPDDEG-----FPSHLLYSI-TTVSKYFM 284
            P  T  + + ++LE   PGT++A  N+  +D  + G      P+HL + +  T   Y+ 
Sbjct: 345 APEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYK 404

Query: 285 INQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPAT 344
           +  +T  +     +DR   EL Q+  I+L    +  P    E  + +   V D NDNP  
Sbjct: 405 L--ITSRV-----LDR---ELVQSYNITLTATDQGSPPLSAETHVWLN--VADDNDNPPV 452

Query: 345 CQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSG---SRFLQDP 401
               ++S  +PE   +G  +  +     D DS+  N    +++      G   S ++   
Sbjct: 453 FPHSSYSAYIPENNPRGASIFSVT--ALDPDSK-QNALVTYSLTDDTVQGVPLSSYVSIN 509

Query: 402 AGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIF 461
           + +G +  +   DYE   +L       + +  +D   P   +NV + +    +N+     
Sbjct: 510 SNTGVLYALQSFDYEQFRDL------ELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEI 563

Query: 462 DRPSYVFDVS---ERRPARTRVG----QVRATDKDLPQSSLLYSISTGGASLQYPNVFWI 514
             P+   D S   E  P     G    +V A DKD  Q++ L   S        P +F +
Sbjct: 564 LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWL---SYRLLKASEPGLFAV 620

Query: 515 NPKTGELQ 522
              TGE++
Sbjct: 621 GEHTGEVR 628



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 57/245 (23%), Positives = 93/245 (37%), Gaps = 13/245 (5%)

Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413
           VPE T KG+ + +++K    +  E              G    F  +P  SG ++  G +
Sbjct: 36  VPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSR---GKTQLFAVNPR-SGSLITAGRI 91

Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473
           D E      +     + + V+D    Y    V V I+   +N     F        VSE 
Sbjct: 92  DREELCETVSSCFLNMELLVEDTLKIY---GVEVEIIDINDNAPS--FQEDEVEIKVSEH 146

Query: 474 RPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532
                R     A D D+  +SL  Y +S                K  EL L   +D E  
Sbjct: 147 AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKE 206

Query: 533 PIYILRIQATNNEDT---SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK 589
             ++L + A +  D     +V + V +L+ ND  P+ T + Y +++P ++  GT +    
Sbjct: 207 AAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVN 266

Query: 590 LTCTD 594
            T  D
Sbjct: 267 ATDPD 271


>gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precursor
           [Homo sapiens]
          Length = 935

 Score =  115 bits (287), Expect = 2e-25
 Identities = 140/602 (23%), Positives = 246/602 (40%), Gaps = 59/602 (9%)

Query: 5   IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVN 64
           ++L   LG + G  A  +       +V E +  G+ V   S  L      +     +IV 
Sbjct: 15  LLLCIFLGTLRGFRARQIRY-----SVPEETEKGSFVGNISKDLGLEPRELAKRGVRIV- 68

Query: 65  SNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT 124
           S   T+ F VN  SG+         E+L         ++++ V+D + +  ++V  + + 
Sbjct: 69  SRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDIN 128

Query: 125 DVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMS 184
           D    P FQ +  E   + + E A PG  + +      D   N   SY L SP   F + 
Sbjct: 129 D--NAPSFQEDEVE---IKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-SPNNYFSLQ 182

Query: 185 ANG----------TLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDE 232
             G           L  + + + EA H    L++   D G    K +  ++V ++++ND 
Sbjct: 183 LRGRTDGAKNPELVLEGSLDREKEAAHL---LLLTALDGGDPIRKGAVPIRVVVLDVNDH 239

Query: 233 VPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI----TTVSKYFMINQL 288
           +P FT      +V E +S GT V  + A DP DEG    ++YS     +  S+ F ++  
Sbjct: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDP-DEGINGEVMYSFRNMESKASEIFQLDSQ 298

Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKF 348
           TG +QV   +D +            E+ ++ +  GG      +   V DVNDN       
Sbjct: 299 TGEVQVRGSLDFEKYRF-------YEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITIT 351

Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408
           +    + E +  GT++  LN     D     N + +  +P+ +    +  +      K++
Sbjct: 352 SSINSILENSPPGTVIALLN---VQDQDSGENGQVSCFIPNHL--PFKLEKTYGNYYKLI 406

Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468
               LD E          Y + +   D   P      +V++  + +N+ P +F   SY  
Sbjct: 407 TSRVLDRE------LVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA 460

Query: 469 DVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGA-SLQYPNVFWINPKTGELQLVTK 526
            + E  P    +  V A D D  Q++L+ YS++      +   +   IN  TG L  +  
Sbjct: 461 YIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS 520

Query: 527 VDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGT 583
            D E      LR+ A ++ D   +S+V++++ +L++ND      P   + ALP D   G 
Sbjct: 521 FDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDN----APEILYPALPTDGSTGV 576

Query: 584 NI 585
            +
Sbjct: 577 EL 578



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 101/428 (23%), Positives = 182/428 (42%), Gaps = 52/428 (12%)

Query: 119 LTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176
           + V V DVN+  P F  ++     + + E  + G  +  V A DP++      +  F   
Sbjct: 229 IRVVVLDVNDHIPMFTQSV---YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNM 285

Query: 177 PPKSFRM----SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDE 232
             K+  +    S  G +     LDFE  +R + + ++ +D GGL  +T + + +V++ND 
Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEK-YRFYEMEIQGQDGGGLFTTTTMLITVVDVNDN 344

Query: 233 VPRFTSPTRVYTVLEELSPGTIVA--NITAEDPDDEG-----FPSHLLYSI-TTVSKYFM 284
            P  T  + + ++LE   PGT++A  N+  +D  + G      P+HL + +  T   Y+ 
Sbjct: 345 APEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYK 404

Query: 285 INQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPAT 344
           +  +T  +     +DR   EL Q+  I+L    +  P    E  + +   V D NDNP  
Sbjct: 405 L--ITSRV-----LDR---ELVQSYNITLTATDQGSPPLSAETHVWLN--VADDNDNPPV 452

Query: 345 CQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSG---SRFLQDP 401
               ++S  +PE   +G  +  +     D DS+  N    +++      G   S ++   
Sbjct: 453 FPHSSYSAYIPENNPRGASIFSVT--ALDPDSK-QNALVTYSLTDDTVQGVPLSSYVSIN 509

Query: 402 AGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIF 461
           + +G +  +   DYE   +L       + +  +D   P   +NV + +    +N+     
Sbjct: 510 SNTGVLYALQSFDYEQFRDL------ELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEI 563

Query: 462 DRPSYVFDVS---ERRPARTRVG----QVRATDKDLPQSSLLYSISTGGASLQYPNVFWI 514
             P+   D S   E  P     G    +V A DKD  Q++ L   S        P +F +
Sbjct: 564 LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWL---SYRLLKASEPGLFAV 620

Query: 515 NPKTGELQ 522
              TGE++
Sbjct: 621 GEHTGEVR 628



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 57/245 (23%), Positives = 93/245 (37%), Gaps = 13/245 (5%)

Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413
           VPE T KG+ + +++K    +  E              G    F  +P  SG ++  G +
Sbjct: 36  VPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSR---GKTQLFAVNPR-SGSLITAGRI 91

Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473
           D E      +     + + V+D    Y    V V I+   +N     F        VSE 
Sbjct: 92  DREELCETVSSCFLNMELLVEDTLKIY---GVEVEIIDINDNAPS--FQEDEVEIKVSEH 146

Query: 474 RPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532
                R     A D D+  +SL  Y +S                K  EL L   +D E  
Sbjct: 147 AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKE 206

Query: 533 PIYILRIQATNNEDT---SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK 589
             ++L + A +  D     +V + V +L+ ND  P+ T + Y +++P ++  GT +    
Sbjct: 207 AAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVN 266

Query: 590 LTCTD 594
            T  D
Sbjct: 267 ATDPD 271


>gi|14196455 protocadherin gamma subfamily A, 11 isoform 3 precursor
           [Homo sapiens]
          Length = 750

 Score =  115 bits (287), Expect = 2e-25
 Identities = 140/602 (23%), Positives = 246/602 (40%), Gaps = 59/602 (9%)

Query: 5   IILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVN 64
           ++L   LG + G  A  +       +V E +  G+ V   S  L      +     +IV 
Sbjct: 15  LLLCIFLGTLRGFRARQIRY-----SVPEETEKGSFVGNISKDLGLEPRELAKRGVRIV- 68

Query: 65  SNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVT 124
           S   T+ F VN  SG+         E+L         ++++ V+D + +  ++V  + + 
Sbjct: 69  SRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDIN 128

Query: 125 DVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMS 184
           D    P FQ +  E   + + E A PG  + +      D   N   SY L SP   F + 
Sbjct: 129 D--NAPSFQEDEVE---IKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-SPNNYFSLQ 182

Query: 185 ANG----------TLFSTTELDFEAGHRSFHLIVEVRDSGG--LKASTELQVNIVNLNDE 232
             G           L  + + + EA H    L++   D G    K +  ++V ++++ND 
Sbjct: 183 LRGRTDGAKNPELVLEGSLDREKEAAHL---LLLTALDGGDPIRKGAVPIRVVVLDVNDH 239

Query: 233 VPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI----TTVSKYFMINQL 288
           +P FT      +V E +S GT V  + A DP DEG    ++YS     +  S+ F ++  
Sbjct: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDP-DEGINGEVMYSFRNMESKASEIFQLDSQ 298

Query: 289 TGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKF 348
           TG +QV   +D +            E+ ++ +  GG      +   V DVNDN       
Sbjct: 299 TGEVQVRGSLDFEKYRF-------YEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITIT 351

Query: 349 TFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIV 408
           +    + E +  GT++  LN     D     N + +  +P+ +    +  +      K++
Sbjct: 352 SSINSILENSPPGTVIALLN---VQDQDSGENGQVSCFIPNHL--PFKLEKTYGNYYKLI 406

Query: 409 LIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVF 468
               LD E          Y + +   D   P      +V++  + +N+ P +F   SY  
Sbjct: 407 TSRVLDRE------LVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA 460

Query: 469 DVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGA-SLQYPNVFWINPKTGELQLVTK 526
            + E  P    +  V A D D  Q++L+ YS++      +   +   IN  TG L  +  
Sbjct: 461 YIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS 520

Query: 527 VDCETTPIYILRIQATNNED---TSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGT 583
            D E      LR+ A ++ D   +S+V++++ +L++ND      P   + ALP D   G 
Sbjct: 521 FDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDN----APEILYPALPTDGSTGV 576

Query: 584 NI 585
            +
Sbjct: 577 EL 578



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 101/426 (23%), Positives = 180/426 (42%), Gaps = 52/426 (12%)

Query: 119 LTVQVTDVNEP-PQFQGNLAEGLHLYIVERANPGF-IYQVEAFDPEDTSRNIPLSYFLIS 176
           + V V DVN+  P F  ++     + + E  + G  +  V A DP++      +  F   
Sbjct: 229 IRVVVLDVNDHIPMFTQSV---YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNM 285

Query: 177 PPKSFRM----SANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDE 232
             K+  +    S  G +     LDFE  +R + + ++ +D GGL  +T + + +V++ND 
Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEK-YRFYEMEIQGQDGGGLFTTTTMLITVVDVNDN 344

Query: 233 VPRFTSPTRVYTVLEELSPGTIVA--NITAEDPDDEG-----FPSHLLYSI-TTVSKYFM 284
            P  T  + + ++LE   PGT++A  N+  +D  + G      P+HL + +  T   Y+ 
Sbjct: 345 APEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYK 404

Query: 285 INQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPAT 344
           +  +T  +     +DR   EL Q+  I+L    +  P    E  + +   V D NDNP  
Sbjct: 405 L--ITSRV-----LDR---ELVQSYNITLTATDQGSPPLSAETHVWLN--VADDNDNPPV 452

Query: 345 CQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSG---SRFLQDP 401
               ++S  +PE   +G  +  +     D DS+  N    +++      G   S ++   
Sbjct: 453 FPHSSYSAYIPENNPRGASIFSVT--ALDPDSK-QNALVTYSLTDDTVQGVPLSSYVSIN 509

Query: 402 AGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIF 461
           + +G +  +   DYE   +L       + +  +D   P   +NV + +    +N+     
Sbjct: 510 SNTGVLYALQSFDYEQFRDL------ELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEI 563

Query: 462 DRPSYVFDVS---ERRPARTRVG----QVRATDKDLPQSSLLYSISTGGASLQYPNVFWI 514
             P+   D S   E  P     G    +V A DKD  Q++ L   S        P +F +
Sbjct: 564 LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWL---SYRLLKASEPGLFAV 620

Query: 515 NPKTGE 520
              TGE
Sbjct: 621 GEHTGE 626



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 57/245 (23%), Positives = 93/245 (37%), Gaps = 13/245 (5%)

Query: 354 VPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDL 413
           VPE T KG+ + +++K    +  E              G    F  +P  SG ++  G +
Sbjct: 36  VPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSR---GKTQLFAVNPR-SGSLITAGRI 91

Query: 414 DYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSER 473
           D E      +     + + V+D    Y    V V I+   +N     F        VSE 
Sbjct: 92  DREELCETVSSCFLNMELLVEDTLKIY---GVEVEIIDINDNAPS--FQEDEVEIKVSEH 146

Query: 474 RPARTRVGQVRATDKDLPQSSLL-YSISTGGASLQYPNVFWINPKTGELQLVTKVDCETT 532
                R     A D D+  +SL  Y +S                K  EL L   +D E  
Sbjct: 147 AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKE 206

Query: 533 PIYILRIQATNNEDT---SSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFK 589
             ++L + A +  D     +V + V +L+ ND  P+ T + Y +++P ++  GT +    
Sbjct: 207 AAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVN 266

Query: 590 LTCTD 594
            T  D
Sbjct: 267 ATDPD 271


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.135    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,785,776
Number of Sequences: 37866
Number of extensions: 1703753
Number of successful extensions: 6605
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 188
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 3678
Number of HSP's gapped (non-prelim): 843
length of query: 885
length of database: 18,247,518
effective HSP length: 111
effective length of query: 774
effective length of database: 14,044,392
effective search space: 10870359408
effective search space used: 10870359408
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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