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Search of human proteins with 40217820
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40217820 slit and trk like 3 protein [Homo sapiens]
(977 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40217820 slit and trk like 3 protein [Homo sapiens] 2005 0.0
gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens] 694 0.0
gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens] 652 0.0
gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens] 652 0.0
gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens] 652 0.0
gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens] 652 0.0
gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens] 652 0.0
gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens] 652 0.0
gi|221136961 SLIT and NTRK-like family, member 2 [Homo sapiens] 652 0.0
gi|221136957 SLIT and NTRK-like family, member 2 [Homo sapiens] 652 0.0
gi|33504581 SLIT and NTRK-like family, member 2 [Homo sapiens] 652 0.0
gi|27436867 slit and trk like 4 protein [Homo sapiens] 587 e-167
gi|40217825 slit and trk like 6 [Homo sapiens] 530 e-150
gi|40217817 slit and trk like 1 protein [Homo sapiens] 489 e-138
gi|194440719 chondroadherin-like [Homo sapiens] 115 3e-25
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 107 5e-23
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 107 5e-23
gi|198041768 synleurin [Homo sapiens] 103 8e-22
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 101 3e-21
gi|11321571 slit homolog 3 [Homo sapiens] 100 9e-21
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho... 97 6e-20
gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 97 7e-20
gi|4759146 slit homolog 2 [Homo sapiens] 97 1e-19
gi|109150416 peroxidasin [Homo sapiens] 96 2e-19
gi|188528675 slit homolog 1 [Homo sapiens] 96 2e-19
gi|31542244 leucine rich repeat and fibronectin type III domain ... 95 3e-19
gi|191252816 extracellular leucine-rich repeat and fibronectin t... 93 1e-18
gi|116268101 leucine rich repeat containing 62 [Homo sapiens] 93 1e-18
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 92 2e-18
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho... 92 3e-18
>gi|40217820 slit and trk like 3 protein [Homo sapiens]
Length = 977
Score = 2005 bits (5194), Expect = 0.0
Identities = 977/977 (100%), Positives = 977/977 (100%)
Query: 1 MKPSIAEMLHRGRMLWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIH 60
MKPSIAEMLHRGRMLWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIH
Sbjct: 1 MKPSIAEMLHRGRMLWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIH 60
Query: 61 CDSKGFTNISQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGA 120
CDSKGFTNISQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGA
Sbjct: 61 CDSKGFTNISQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGA 120
Query: 121 FNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLIL 180
FNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLIL
Sbjct: 121 FNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLIL 180
Query: 181 NDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEI 240
NDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEI
Sbjct: 181 NDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEI 240
Query: 241 VQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSS 300
VQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSS
Sbjct: 241 VQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSS 300
Query: 301 SKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPI 360
SKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPI
Sbjct: 301 SKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPI 360
Query: 361 APYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLI 420
APYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLI
Sbjct: 361 APYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLI 420
Query: 421 QKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQ 480
QKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQ
Sbjct: 421 QKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQ 480
Query: 481 SLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFL 540
SLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFL
Sbjct: 481 SLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFL 540
Query: 541 YLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHR 600
YLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHR
Sbjct: 541 YLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHR 600
Query: 601 DVRTIELEVLCPEMLHVAPAGESPAQPGDSHLIGAPTSASPYEFSPPGGPVPLSVLILSL 660
DVRTIELEVLCPEMLHVAPAGESPAQPGDSHLIGAPTSASPYEFSPPGGPVPLSVLILSL
Sbjct: 601 DVRTIELEVLCPEMLHVAPAGESPAQPGDSHLIGAPTSASPYEFSPPGGPVPLSVLILSL 660
Query: 661 LVLFFSAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDGGGGGGGSG 720
LVLFFSAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDGGGGGGGSG
Sbjct: 661 LVLFFSAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDGGGGGGGSG 720
Query: 721 GGGRPTLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSAERGGP 780
GGGRPTLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSAERGGP
Sbjct: 721 GGGRPTLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSAERGGP 780
Query: 781 GTQPPGMGEALLGSEQFAETPKENHSNYRTLLEKEKEWALAVSSSQLNTIVTVNHHHPHH 840
GTQPPGMGEALLGSEQFAETPKENHSNYRTLLEKEKEWALAVSSSQLNTIVTVNHHHPHH
Sbjct: 781 GTQPPGMGEALLGSEQFAETPKENHSNYRTLLEKEKEWALAVSSSQLNTIVTVNHHHPHH 840
Query: 841 PAVGGVSGVVGGTGGDLAGFRHHEKNGGVVLFPPGGGCGSGSMLLDRERPQPAPCTVGFV 900
PAVGGVSGVVGGTGGDLAGFRHHEKNGGVVLFPPGGGCGSGSMLLDRERPQPAPCTVGFV
Sbjct: 841 PAVGGVSGVVGGTGGDLAGFRHHEKNGGVVLFPPGGGCGSGSMLLDRERPQPAPCTVGFV 900
Query: 901 DCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQTQKSDYLELRAKL 960
DCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQTQKSDYLELRAKL
Sbjct: 901 DCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQTQKSDYLELRAKL 960
Query: 961 QTKPDYLEVLEKTTYRF 977
QTKPDYLEVLEKTTYRF
Sbjct: 961 QTKPDYLEVLEKTTYRF 977
>gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]
Length = 958
Score = 694 bits (1791), Expect = 0.0
Identities = 417/1012 (41%), Positives = 582/1012 (57%), Gaps = 108/1012 (10%)
Query: 4 SIAEMLHRGRMLWIILLSTIALGWTTPIPLIEDSEEID---EPCFDPCYCEVKESLFHIH 60
++ + LHR W +L T+A T+ + + +E ID E C + C CE K+ + +
Sbjct: 9 TLEQDLHRKMHSW--MLQTLAFAVTSLV--LSCAETIDYYGEICDNACPCEEKDGILTVS 64
Query: 61 CDSKGFTNISQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGA 120
C+++G ++S+I+ + L L N + +LY N F++ A ++LG+N +QDI+TGA
Sbjct: 65 CENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGA 124
Query: 121 FNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLIL 180
F+GL+ L+RL+L+ NKL++ R+DTFLGLE+LEYLQ DYN I IE AF L L+VLIL
Sbjct: 125 FHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLIL 184
Query: 181 NDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEI 240
NDNL+ LP NLF+ V LTHLDLRGNRLK+L Y G+L H+ + ++ELQLEENPWNC+CE+
Sbjct: 185 NDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDK-VVELQLEENPWNCSCEL 243
Query: 241 VQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTELCP--LLSDSEVEASLGIPHS 298
+ LK WL+ I Y+ALVGD+ CETPF HG+DL E+ K ELCP L+SD E+ P +
Sbjct: 244 ISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMR-----PQT 298
Query: 299 SSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPG---P 355
S T P+S+ S T+SS YK K PK T+QP PR TS+
Sbjct: 299 PLSTTGYLHTTPASVNSVA--TSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYS 356
Query: 356 NQPPIAPYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYL 415
N P YQT+ P+P+ CPT C+CNL I+DLGL VNC+ER +I+EL P+P N KK+YL
Sbjct: 357 NYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYL 416
Query: 416 SSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGM 475
+ N I + R+DF + LDLLHLGNNRIS +QD AF +L NL+ L+LNGN IE+L+P +
Sbjct: 417 TENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPEL 476
Query: 476 FRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLR 535
F GLQSL YL+ ++N+IREIQ F +PNL+LLFLNNNLL+ +P+ F+G +L RLNLR
Sbjct: 477 FYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLR 536
Query: 536 KNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPE 595
N+F LPV+GVL+ L +++QIDL++NPWDCTCD+V K W+E + +V +V+C++P+
Sbjct: 537 SNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPK 596
Query: 596 NLTHRDVRTIELEVLCPEMLHVAPAGESPAQPGDSHLIGAPTSA-------SPYEFSPPG 648
D+R+I+ E+LCP+ V + +P+ A T A +P G
Sbjct: 597 KFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGG 656
Query: 649 GP--VPLSVLILSLLVLFFSAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCH 706
G VPLSVLILSLL++F +VFVAAGLF V++RR+K + D++ MQ +
Sbjct: 657 GASSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNS-DVSSFNMQ-Y 714
Query: 707 RLFEDGGGGGGGSGGGGRPTL-----SSPEKAPPVGHVYEYIPHPVTQMCNNPIY----- 756
++ GGGGG+GG + + P+ P GHVYEYIPHP+ MC NPIY
Sbjct: 715 SVY----GGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSREG 770
Query: 757 ------KPREEEEVAVSS-----AQEAGSAERGGPGTQPPGMGEALLGSEQFAETPKENH 805
K E +V SS Q+ P QPP + G E+ E+
Sbjct: 771 NSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEEERRESHHLRS 830
Query: 806 SNYR-TLLEKEKEWALAVSSSQ--LNTIVTVNHHHPHHPAVGGVSGVVGGTGGDLAGFRH 862
Y + +E ++ V + I+ + H PA G L +
Sbjct: 831 PAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPA-----------GNSLPEYPK 879
Query: 863 HEKNGGVVLFPPGGGCGSGSMLLDRERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQY 922
+ F P D RP ++HP
Sbjct: 880 FPCSPAAYTFSPN---------YDLRRPHQ---------------------YLHPGA--- 906
Query: 923 PDLQQDARLKETLLFSAGKGFTDHQTQKSDYLELRAKLQTKPDYLEVLEKTT 974
D+RL+E +L+S + +++YLEL+AKL +PDYLEVLEK T
Sbjct: 907 ----GDSRLREPVLYSPPSAVFV-EPNRNEYLELKAKLNVEPDYLEVLEKQT 953
>gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 652 bits (1682), Expect = 0.0
Identities = 358/815 (43%), Positives = 492/815 (60%), Gaps = 66/815 (8%)
Query: 15 LWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITE 74
+W + + T+A I E + + C C CE KE++ +I+C++KGFT +S +
Sbjct: 5 VWFLSVLTVA-----GILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQP 59
Query: 75 FWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHE 134
R ++L+L N + +LY N F++ +NAV+++LGNN LQ+I+TGAF+GLK LKRL+L+
Sbjct: 60 PQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNN 119
Query: 135 NKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFK 194
NKL++ R DTFLGLESLEYLQADYN I IE+GAF L+KL+VLILNDNL+ LP+N+F+
Sbjct: 120 NKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR 179
Query: 195 AVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTA 254
V LTHLDLRGNRLKV+ + G+L+HIG +ME+QLEENPWNCTC+++ LK+WL+ I T
Sbjct: 180 FVLLTHLDLRGNRLKVMPFAGVLEHIG-GIMEIQLEENPWNCTCDLLPLKAWLDTI--TV 236
Query: 255 LVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSML 314
VG+I CETPF HGKD+ ++ + +LCP S S+ +S H+ + + PT
Sbjct: 237 FVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASD--SSQRGSHADTHVQRLSPTM----- 289
Query: 315 SSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQP-------PIAPYQTRP 367
N PT+ P+ RPP P PI YQT+
Sbjct: 290 ---------------NPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKS 334
Query: 368 PIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSD 427
P+P+ CP+ C C +D GL VNC+ER F NIS+L P+P + KKLYL+ N +Q +Y++D
Sbjct: 335 PVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKND 394
Query: 428 FWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYF 487
+SSLDLLHLGNNRI+ +Q+GAF NL +L+ L+LNGN +E L P MF GLQSL YLY
Sbjct: 395 LLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYL 454
Query: 488 EFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGV 547
E+NVI+EI+P F + NL+LLFLNNNLLR+LP + F GT+L RLNLR N+F +LPV GV
Sbjct: 455 EYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGV 514
Query: 548 LEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIEL 607
L+ L A +QIDL ENPWDCTCD++ K W E +S ++ +V C SP ++ +
Sbjct: 515 LDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGR 574
Query: 608 EVLCPEMLHVAPAGESPAQPGDSHLIGAP--TSASPYEFSPPGGPVPLSVLILSLLVLFF 665
E +CP+ +P +H P S SP + VPLSVLIL LLV+F
Sbjct: 575 EAICPD----SPNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFI 630
Query: 666 SAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDGGGGGGGSGGGGRP 725
+V AGLF +VL +RRK +P + +D++ Q+Q G
Sbjct: 631 LSVCFGAGLFVFVL-KRRKGVPSVPRNTNNLDVSSFQLQY-----------------GSY 672
Query: 726 TLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSAERGGPGTQPP 785
+ +K GHVY YIP PV QMC NPIY +E + VA + S + P
Sbjct: 673 NTETHDKTD--GHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQEFSYSNLEEKKEEP 730
Query: 786 GMGEALLGSEQFAE---TPKENHSNYRTLLEKEKE 817
+ + + E TP+E Y+ + E+ KE
Sbjct: 731 ATPAYTISATELLEKQATPREPELLYQNIAERVKE 765
Score = 35.4 bits (80), Expect = 0.26
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 888 ERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQ 947
ER + P + G V + T+PK + P + QD R+ +T+L+ + Q
Sbjct: 761 ERVKELP-SAGLVHYNFCTLPKRQ----FAPSYESRRQNQD-RINKTVLYGTPRKCFVGQ 814
Query: 948 TQKSDYLELRAKLQTKPDYLEVLEKTT 974
++ + L L+AK Q++PDYLEVLEK T
Sbjct: 815 SKPNHPL-LQAKPQSEPDYLEVLEKQT 840
>gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 652 bits (1682), Expect = 0.0
Identities = 358/815 (43%), Positives = 492/815 (60%), Gaps = 66/815 (8%)
Query: 15 LWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITE 74
+W + + T+A I E + + C C CE KE++ +I+C++KGFT +S +
Sbjct: 5 VWFLSVLTVA-----GILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQP 59
Query: 75 FWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHE 134
R ++L+L N + +LY N F++ +NAV+++LGNN LQ+I+TGAF+GLK LKRL+L+
Sbjct: 60 PQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNN 119
Query: 135 NKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFK 194
NKL++ R DTFLGLESLEYLQADYN I IE+GAF L+KL+VLILNDNL+ LP+N+F+
Sbjct: 120 NKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR 179
Query: 195 AVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTA 254
V LTHLDLRGNRLKV+ + G+L+HIG +ME+QLEENPWNCTC+++ LK+WL+ I T
Sbjct: 180 FVLLTHLDLRGNRLKVMPFAGVLEHIG-GIMEIQLEENPWNCTCDLLPLKAWLDTI--TV 236
Query: 255 LVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSML 314
VG+I CETPF HGKD+ ++ + +LCP S S+ +S H+ + + PT
Sbjct: 237 FVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASD--SSQRGSHADTHVQRLSPTM----- 289
Query: 315 SSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQP-------PIAPYQTRP 367
N PT+ P+ RPP P PI YQT+
Sbjct: 290 ---------------NPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKS 334
Query: 368 PIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSD 427
P+P+ CP+ C C +D GL VNC+ER F NIS+L P+P + KKLYL+ N +Q +Y++D
Sbjct: 335 PVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKND 394
Query: 428 FWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYF 487
+SSLDLLHLGNNRI+ +Q+GAF NL +L+ L+LNGN +E L P MF GLQSL YLY
Sbjct: 395 LLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYL 454
Query: 488 EFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGV 547
E+NVI+EI+P F + NL+LLFLNNNLLR+LP + F GT+L RLNLR N+F +LPV GV
Sbjct: 455 EYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGV 514
Query: 548 LEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIEL 607
L+ L A +QIDL ENPWDCTCD++ K W E +S ++ +V C SP ++ +
Sbjct: 515 LDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGR 574
Query: 608 EVLCPEMLHVAPAGESPAQPGDSHLIGAP--TSASPYEFSPPGGPVPLSVLILSLLVLFF 665
E +CP+ +P +H P S SP + VPLSVLIL LLV+F
Sbjct: 575 EAICPD----SPNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFI 630
Query: 666 SAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDGGGGGGGSGGGGRP 725
+V AGLF +VL +RRK +P + +D++ Q+Q G
Sbjct: 631 LSVCFGAGLFVFVL-KRRKGVPSVPRNTNNLDVSSFQLQY-----------------GSY 672
Query: 726 TLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSAERGGPGTQPP 785
+ +K GHVY YIP PV QMC NPIY +E + VA + S + P
Sbjct: 673 NTETHDKTD--GHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQEFSYSNLEEKKEEP 730
Query: 786 GMGEALLGSEQFAE---TPKENHSNYRTLLEKEKE 817
+ + + E TP+E Y+ + E+ KE
Sbjct: 731 ATPAYTISATELLEKQATPREPELLYQNIAERVKE 765
Score = 35.4 bits (80), Expect = 0.26
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 888 ERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQ 947
ER + P + G V + T+PK + P + QD R+ +T+L+ + Q
Sbjct: 761 ERVKELP-SAGLVHYNFCTLPKRQ----FAPSYESRRQNQD-RINKTVLYGTPRKCFVGQ 814
Query: 948 TQKSDYLELRAKLQTKPDYLEVLEKTT 974
++ + L L+AK Q++PDYLEVLEK T
Sbjct: 815 SKPNHPL-LQAKPQSEPDYLEVLEKQT 840
>gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 652 bits (1682), Expect = 0.0
Identities = 358/815 (43%), Positives = 492/815 (60%), Gaps = 66/815 (8%)
Query: 15 LWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITE 74
+W + + T+A I E + + C C CE KE++ +I+C++KGFT +S +
Sbjct: 5 VWFLSVLTVA-----GILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQP 59
Query: 75 FWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHE 134
R ++L+L N + +LY N F++ +NAV+++LGNN LQ+I+TGAF+GLK LKRL+L+
Sbjct: 60 PQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNN 119
Query: 135 NKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFK 194
NKL++ R DTFLGLESLEYLQADYN I IE+GAF L+KL+VLILNDNL+ LP+N+F+
Sbjct: 120 NKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR 179
Query: 195 AVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTA 254
V LTHLDLRGNRLKV+ + G+L+HIG +ME+QLEENPWNCTC+++ LK+WL+ I T
Sbjct: 180 FVLLTHLDLRGNRLKVMPFAGVLEHIG-GIMEIQLEENPWNCTCDLLPLKAWLDTI--TV 236
Query: 255 LVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSML 314
VG+I CETPF HGKD+ ++ + +LCP S S+ +S H+ + + PT
Sbjct: 237 FVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASD--SSQRGSHADTHVQRLSPTM----- 289
Query: 315 SSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQP-------PIAPYQTRP 367
N PT+ P+ RPP P PI YQT+
Sbjct: 290 ---------------NPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKS 334
Query: 368 PIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSD 427
P+P+ CP+ C C +D GL VNC+ER F NIS+L P+P + KKLYL+ N +Q +Y++D
Sbjct: 335 PVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKND 394
Query: 428 FWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYF 487
+SSLDLLHLGNNRI+ +Q+GAF NL +L+ L+LNGN +E L P MF GLQSL YLY
Sbjct: 395 LLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYL 454
Query: 488 EFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGV 547
E+NVI+EI+P F + NL+LLFLNNNLLR+LP + F GT+L RLNLR N+F +LPV GV
Sbjct: 455 EYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGV 514
Query: 548 LEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIEL 607
L+ L A +QIDL ENPWDCTCD++ K W E +S ++ +V C SP ++ +
Sbjct: 515 LDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGR 574
Query: 608 EVLCPEMLHVAPAGESPAQPGDSHLIGAP--TSASPYEFSPPGGPVPLSVLILSLLVLFF 665
E +CP+ +P +H P S SP + VPLSVLIL LLV+F
Sbjct: 575 EAICPD----SPNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFI 630
Query: 666 SAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDGGGGGGGSGGGGRP 725
+V AGLF +VL +RRK +P + +D++ Q+Q G
Sbjct: 631 LSVCFGAGLFVFVL-KRRKGVPSVPRNTNNLDVSSFQLQY-----------------GSY 672
Query: 726 TLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSAERGGPGTQPP 785
+ +K GHVY YIP PV QMC NPIY +E + VA + S + P
Sbjct: 673 NTETHDKTD--GHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQEFSYSNLEEKKEEP 730
Query: 786 GMGEALLGSEQFAE---TPKENHSNYRTLLEKEKE 817
+ + + E TP+E Y+ + E+ KE
Sbjct: 731 ATPAYTISATELLEKQATPREPELLYQNIAERVKE 765
Score = 35.4 bits (80), Expect = 0.26
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 888 ERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQ 947
ER + P + G V + T+PK + P + QD R+ +T+L+ + Q
Sbjct: 761 ERVKELP-SAGLVHYNFCTLPKRQ----FAPSYESRRQNQD-RINKTVLYGTPRKCFVGQ 814
Query: 948 TQKSDYLELRAKLQTKPDYLEVLEKTT 974
++ + L L+AK Q++PDYLEVLEK T
Sbjct: 815 SKPNHPL-LQAKPQSEPDYLEVLEKQT 840
>gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 652 bits (1682), Expect = 0.0
Identities = 358/815 (43%), Positives = 492/815 (60%), Gaps = 66/815 (8%)
Query: 15 LWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITE 74
+W + + T+A I E + + C C CE KE++ +I+C++KGFT +S +
Sbjct: 5 VWFLSVLTVA-----GILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQP 59
Query: 75 FWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHE 134
R ++L+L N + +LY N F++ +NAV+++LGNN LQ+I+TGAF+GLK LKRL+L+
Sbjct: 60 PQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNN 119
Query: 135 NKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFK 194
NKL++ R DTFLGLESLEYLQADYN I IE+GAF L+KL+VLILNDNL+ LP+N+F+
Sbjct: 120 NKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR 179
Query: 195 AVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTA 254
V LTHLDLRGNRLKV+ + G+L+HIG +ME+QLEENPWNCTC+++ LK+WL+ I T
Sbjct: 180 FVLLTHLDLRGNRLKVMPFAGVLEHIG-GIMEIQLEENPWNCTCDLLPLKAWLDTI--TV 236
Query: 255 LVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSML 314
VG+I CETPF HGKD+ ++ + +LCP S S+ +S H+ + + PT
Sbjct: 237 FVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASD--SSQRGSHADTHVQRLSPTM----- 289
Query: 315 SSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQP-------PIAPYQTRP 367
N PT+ P+ RPP P PI YQT+
Sbjct: 290 ---------------NPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKS 334
Query: 368 PIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSD 427
P+P+ CP+ C C +D GL VNC+ER F NIS+L P+P + KKLYL+ N +Q +Y++D
Sbjct: 335 PVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKND 394
Query: 428 FWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYF 487
+SSLDLLHLGNNRI+ +Q+GAF NL +L+ L+LNGN +E L P MF GLQSL YLY
Sbjct: 395 LLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYL 454
Query: 488 EFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGV 547
E+NVI+EI+P F + NL+LLFLNNNLLR+LP + F GT+L RLNLR N+F +LPV GV
Sbjct: 455 EYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGV 514
Query: 548 LEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIEL 607
L+ L A +QIDL ENPWDCTCD++ K W E +S ++ +V C SP ++ +
Sbjct: 515 LDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGR 574
Query: 608 EVLCPEMLHVAPAGESPAQPGDSHLIGAP--TSASPYEFSPPGGPVPLSVLILSLLVLFF 665
E +CP+ +P +H P S SP + VPLSVLIL LLV+F
Sbjct: 575 EAICPD----SPNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFI 630
Query: 666 SAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDGGGGGGGSGGGGRP 725
+V AGLF +VL +RRK +P + +D++ Q+Q G
Sbjct: 631 LSVCFGAGLFVFVL-KRRKGVPSVPRNTNNLDVSSFQLQY-----------------GSY 672
Query: 726 TLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSAERGGPGTQPP 785
+ +K GHVY YIP PV QMC NPIY +E + VA + S + P
Sbjct: 673 NTETHDKTD--GHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQEFSYSNLEEKKEEP 730
Query: 786 GMGEALLGSEQFAE---TPKENHSNYRTLLEKEKE 817
+ + + E TP+E Y+ + E+ KE
Sbjct: 731 ATPAYTISATELLEKQATPREPELLYQNIAERVKE 765
Score = 35.4 bits (80), Expect = 0.26
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 888 ERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQ 947
ER + P + G V + T+PK + P + QD R+ +T+L+ + Q
Sbjct: 761 ERVKELP-SAGLVHYNFCTLPKRQ----FAPSYESRRQNQD-RINKTVLYGTPRKCFVGQ 814
Query: 948 TQKSDYLELRAKLQTKPDYLEVLEKTT 974
++ + L L+AK Q++PDYLEVLEK T
Sbjct: 815 SKPNHPL-LQAKPQSEPDYLEVLEKQT 840
>gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 652 bits (1682), Expect = 0.0
Identities = 358/815 (43%), Positives = 492/815 (60%), Gaps = 66/815 (8%)
Query: 15 LWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITE 74
+W + + T+A I E + + C C CE KE++ +I+C++KGFT +S +
Sbjct: 5 VWFLSVLTVA-----GILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQP 59
Query: 75 FWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHE 134
R ++L+L N + +LY N F++ +NAV+++LGNN LQ+I+TGAF+GLK LKRL+L+
Sbjct: 60 PQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNN 119
Query: 135 NKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFK 194
NKL++ R DTFLGLESLEYLQADYN I IE+GAF L+KL+VLILNDNL+ LP+N+F+
Sbjct: 120 NKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR 179
Query: 195 AVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTA 254
V LTHLDLRGNRLKV+ + G+L+HIG +ME+QLEENPWNCTC+++ LK+WL+ I T
Sbjct: 180 FVLLTHLDLRGNRLKVMPFAGVLEHIG-GIMEIQLEENPWNCTCDLLPLKAWLDTI--TV 236
Query: 255 LVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSML 314
VG+I CETPF HGKD+ ++ + +LCP S S+ +S H+ + + PT
Sbjct: 237 FVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASD--SSQRGSHADTHVQRLSPTM----- 289
Query: 315 SSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQP-------PIAPYQTRP 367
N PT+ P+ RPP P PI YQT+
Sbjct: 290 ---------------NPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKS 334
Query: 368 PIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSD 427
P+P+ CP+ C C +D GL VNC+ER F NIS+L P+P + KKLYL+ N +Q +Y++D
Sbjct: 335 PVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKND 394
Query: 428 FWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYF 487
+SSLDLLHLGNNRI+ +Q+GAF NL +L+ L+LNGN +E L P MF GLQSL YLY
Sbjct: 395 LLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYL 454
Query: 488 EFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGV 547
E+NVI+EI+P F + NL+LLFLNNNLLR+LP + F GT+L RLNLR N+F +LPV GV
Sbjct: 455 EYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGV 514
Query: 548 LEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIEL 607
L+ L A +QIDL ENPWDCTCD++ K W E +S ++ +V C SP ++ +
Sbjct: 515 LDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGR 574
Query: 608 EVLCPEMLHVAPAGESPAQPGDSHLIGAP--TSASPYEFSPPGGPVPLSVLILSLLVLFF 665
E +CP+ +P +H P S SP + VPLSVLIL LLV+F
Sbjct: 575 EAICPD----SPNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFI 630
Query: 666 SAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDGGGGGGGSGGGGRP 725
+V AGLF +VL +RRK +P + +D++ Q+Q G
Sbjct: 631 LSVCFGAGLFVFVL-KRRKGVPSVPRNTNNLDVSSFQLQY-----------------GSY 672
Query: 726 TLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSAERGGPGTQPP 785
+ +K GHVY YIP PV QMC NPIY +E + VA + S + P
Sbjct: 673 NTETHDKTD--GHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQEFSYSNLEEKKEEP 730
Query: 786 GMGEALLGSEQFAE---TPKENHSNYRTLLEKEKE 817
+ + + E TP+E Y+ + E+ KE
Sbjct: 731 ATPAYTISATELLEKQATPREPELLYQNIAERVKE 765
Score = 35.4 bits (80), Expect = 0.26
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 888 ERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQ 947
ER + P + G V + T+PK + P + QD R+ +T+L+ + Q
Sbjct: 761 ERVKELP-SAGLVHYNFCTLPKRQ----FAPSYESRRQNQD-RINKTVLYGTPRKCFVGQ 814
Query: 948 TQKSDYLELRAKLQTKPDYLEVLEKTT 974
++ + L L+AK Q++PDYLEVLEK T
Sbjct: 815 SKPNHPL-LQAKPQSEPDYLEVLEKQT 840
>gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 652 bits (1682), Expect = 0.0
Identities = 358/815 (43%), Positives = 492/815 (60%), Gaps = 66/815 (8%)
Query: 15 LWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITE 74
+W + + T+A I E + + C C CE KE++ +I+C++KGFT +S +
Sbjct: 5 VWFLSVLTVA-----GILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQP 59
Query: 75 FWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHE 134
R ++L+L N + +LY N F++ +NAV+++LGNN LQ+I+TGAF+GLK LKRL+L+
Sbjct: 60 PQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNN 119
Query: 135 NKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFK 194
NKL++ R DTFLGLESLEYLQADYN I IE+GAF L+KL+VLILNDNL+ LP+N+F+
Sbjct: 120 NKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR 179
Query: 195 AVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTA 254
V LTHLDLRGNRLKV+ + G+L+HIG +ME+QLEENPWNCTC+++ LK+WL+ I T
Sbjct: 180 FVLLTHLDLRGNRLKVMPFAGVLEHIG-GIMEIQLEENPWNCTCDLLPLKAWLDTI--TV 236
Query: 255 LVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSML 314
VG+I CETPF HGKD+ ++ + +LCP S S+ +S H+ + + PT
Sbjct: 237 FVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASD--SSQRGSHADTHVQRLSPTM----- 289
Query: 315 SSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQP-------PIAPYQTRP 367
N PT+ P+ RPP P PI YQT+
Sbjct: 290 ---------------NPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKS 334
Query: 368 PIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSD 427
P+P+ CP+ C C +D GL VNC+ER F NIS+L P+P + KKLYL+ N +Q +Y++D
Sbjct: 335 PVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKND 394
Query: 428 FWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYF 487
+SSLDLLHLGNNRI+ +Q+GAF NL +L+ L+LNGN +E L P MF GLQSL YLY
Sbjct: 395 LLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYL 454
Query: 488 EFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGV 547
E+NVI+EI+P F + NL+LLFLNNNLLR+LP + F GT+L RLNLR N+F +LPV GV
Sbjct: 455 EYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGV 514
Query: 548 LEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIEL 607
L+ L A +QIDL ENPWDCTCD++ K W E +S ++ +V C SP ++ +
Sbjct: 515 LDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGR 574
Query: 608 EVLCPEMLHVAPAGESPAQPGDSHLIGAP--TSASPYEFSPPGGPVPLSVLILSLLVLFF 665
E +CP+ +P +H P S SP + VPLSVLIL LLV+F
Sbjct: 575 EAICPD----SPNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFI 630
Query: 666 SAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDGGGGGGGSGGGGRP 725
+V AGLF +VL +RRK +P + +D++ Q+Q G
Sbjct: 631 LSVCFGAGLFVFVL-KRRKGVPSVPRNTNNLDVSSFQLQY-----------------GSY 672
Query: 726 TLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSAERGGPGTQPP 785
+ +K GHVY YIP PV QMC NPIY +E + VA + S + P
Sbjct: 673 NTETHDKTD--GHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQEFSYSNLEEKKEEP 730
Query: 786 GMGEALLGSEQFAE---TPKENHSNYRTLLEKEKE 817
+ + + E TP+E Y+ + E+ KE
Sbjct: 731 ATPAYTISATELLEKQATPREPELLYQNIAERVKE 765
Score = 35.4 bits (80), Expect = 0.26
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 888 ERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQ 947
ER + P + G V + T+PK + P + QD R+ +T+L+ + Q
Sbjct: 761 ERVKELP-SAGLVHYNFCTLPKRQ----FAPSYESRRQNQD-RINKTVLYGTPRKCFVGQ 814
Query: 948 TQKSDYLELRAKLQTKPDYLEVLEKTT 974
++ + L L+AK Q++PDYLEVLEK T
Sbjct: 815 SKPNHPL-LQAKPQSEPDYLEVLEKQT 840
>gi|221136961 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 652 bits (1682), Expect = 0.0
Identities = 358/815 (43%), Positives = 492/815 (60%), Gaps = 66/815 (8%)
Query: 15 LWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITE 74
+W + + T+A I E + + C C CE KE++ +I+C++KGFT +S +
Sbjct: 5 VWFLSVLTVA-----GILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQP 59
Query: 75 FWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHE 134
R ++L+L N + +LY N F++ +NAV+++LGNN LQ+I+TGAF+GLK LKRL+L+
Sbjct: 60 PQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNN 119
Query: 135 NKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFK 194
NKL++ R DTFLGLESLEYLQADYN I IE+GAF L+KL+VLILNDNL+ LP+N+F+
Sbjct: 120 NKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR 179
Query: 195 AVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTA 254
V LTHLDLRGNRLKV+ + G+L+HIG +ME+QLEENPWNCTC+++ LK+WL+ I T
Sbjct: 180 FVLLTHLDLRGNRLKVMPFAGVLEHIG-GIMEIQLEENPWNCTCDLLPLKAWLDTI--TV 236
Query: 255 LVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSML 314
VG+I CETPF HGKD+ ++ + +LCP S S+ +S H+ + + PT
Sbjct: 237 FVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASD--SSQRGSHADTHVQRLSPTM----- 289
Query: 315 SSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQP-------PIAPYQTRP 367
N PT+ P+ RPP P PI YQT+
Sbjct: 290 ---------------NPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKS 334
Query: 368 PIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSD 427
P+P+ CP+ C C +D GL VNC+ER F NIS+L P+P + KKLYL+ N +Q +Y++D
Sbjct: 335 PVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKND 394
Query: 428 FWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYF 487
+SSLDLLHLGNNRI+ +Q+GAF NL +L+ L+LNGN +E L P MF GLQSL YLY
Sbjct: 395 LLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYL 454
Query: 488 EFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGV 547
E+NVI+EI+P F + NL+LLFLNNNLLR+LP + F GT+L RLNLR N+F +LPV GV
Sbjct: 455 EYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGV 514
Query: 548 LEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIEL 607
L+ L A +QIDL ENPWDCTCD++ K W E +S ++ +V C SP ++ +
Sbjct: 515 LDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGR 574
Query: 608 EVLCPEMLHVAPAGESPAQPGDSHLIGAP--TSASPYEFSPPGGPVPLSVLILSLLVLFF 665
E +CP+ +P +H P S SP + VPLSVLIL LLV+F
Sbjct: 575 EAICPD----SPNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFI 630
Query: 666 SAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDGGGGGGGSGGGGRP 725
+V AGLF +VL +RRK +P + +D++ Q+Q G
Sbjct: 631 LSVCFGAGLFVFVL-KRRKGVPSVPRNTNNLDVSSFQLQY-----------------GSY 672
Query: 726 TLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSAERGGPGTQPP 785
+ +K GHVY YIP PV QMC NPIY +E + VA + S + P
Sbjct: 673 NTETHDKTD--GHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQEFSYSNLEEKKEEP 730
Query: 786 GMGEALLGSEQFAE---TPKENHSNYRTLLEKEKE 817
+ + + E TP+E Y+ + E+ KE
Sbjct: 731 ATPAYTISATELLEKQATPREPELLYQNIAERVKE 765
Score = 35.4 bits (80), Expect = 0.26
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 888 ERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQ 947
ER + P + G V + T+PK + P + QD R+ +T+L+ + Q
Sbjct: 761 ERVKELP-SAGLVHYNFCTLPKRQ----FAPSYESRRQNQD-RINKTVLYGTPRKCFVGQ 814
Query: 948 TQKSDYLELRAKLQTKPDYLEVLEKTT 974
++ + L L+AK Q++PDYLEVLEK T
Sbjct: 815 SKPNHPL-LQAKPQSEPDYLEVLEKQT 840
>gi|221136957 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 652 bits (1682), Expect = 0.0
Identities = 358/815 (43%), Positives = 492/815 (60%), Gaps = 66/815 (8%)
Query: 15 LWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITE 74
+W + + T+A I E + + C C CE KE++ +I+C++KGFT +S +
Sbjct: 5 VWFLSVLTVA-----GILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQP 59
Query: 75 FWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHE 134
R ++L+L N + +LY N F++ +NAV+++LGNN LQ+I+TGAF+GLK LKRL+L+
Sbjct: 60 PQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNN 119
Query: 135 NKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFK 194
NKL++ R DTFLGLESLEYLQADYN I IE+GAF L+KL+VLILNDNL+ LP+N+F+
Sbjct: 120 NKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR 179
Query: 195 AVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTA 254
V LTHLDLRGNRLKV+ + G+L+HIG +ME+QLEENPWNCTC+++ LK+WL+ I T
Sbjct: 180 FVLLTHLDLRGNRLKVMPFAGVLEHIG-GIMEIQLEENPWNCTCDLLPLKAWLDTI--TV 236
Query: 255 LVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSML 314
VG+I CETPF HGKD+ ++ + +LCP S S+ +S H+ + + PT
Sbjct: 237 FVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASD--SSQRGSHADTHVQRLSPTM----- 289
Query: 315 SSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQP-------PIAPYQTRP 367
N PT+ P+ RPP P PI YQT+
Sbjct: 290 ---------------NPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKS 334
Query: 368 PIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSD 427
P+P+ CP+ C C +D GL VNC+ER F NIS+L P+P + KKLYL+ N +Q +Y++D
Sbjct: 335 PVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKND 394
Query: 428 FWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYF 487
+SSLDLLHLGNNRI+ +Q+GAF NL +L+ L+LNGN +E L P MF GLQSL YLY
Sbjct: 395 LLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYL 454
Query: 488 EFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGV 547
E+NVI+EI+P F + NL+LLFLNNNLLR+LP + F GT+L RLNLR N+F +LPV GV
Sbjct: 455 EYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGV 514
Query: 548 LEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIEL 607
L+ L A +QIDL ENPWDCTCD++ K W E +S ++ +V C SP ++ +
Sbjct: 515 LDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGR 574
Query: 608 EVLCPEMLHVAPAGESPAQPGDSHLIGAP--TSASPYEFSPPGGPVPLSVLILSLLVLFF 665
E +CP+ +P +H P S SP + VPLSVLIL LLV+F
Sbjct: 575 EAICPD----SPNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFI 630
Query: 666 SAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDGGGGGGGSGGGGRP 725
+V AGLF +VL +RRK +P + +D++ Q+Q G
Sbjct: 631 LSVCFGAGLFVFVL-KRRKGVPSVPRNTNNLDVSSFQLQY-----------------GSY 672
Query: 726 TLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSAERGGPGTQPP 785
+ +K GHVY YIP PV QMC NPIY +E + VA + S + P
Sbjct: 673 NTETHDKTD--GHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQEFSYSNLEEKKEEP 730
Query: 786 GMGEALLGSEQFAE---TPKENHSNYRTLLEKEKE 817
+ + + E TP+E Y+ + E+ KE
Sbjct: 731 ATPAYTISATELLEKQATPREPELLYQNIAERVKE 765
Score = 35.4 bits (80), Expect = 0.26
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 888 ERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQ 947
ER + P + G V + T+PK + P + QD R+ +T+L+ + Q
Sbjct: 761 ERVKELP-SAGLVHYNFCTLPKRQ----FAPSYESRRQNQD-RINKTVLYGTPRKCFVGQ 814
Query: 948 TQKSDYLELRAKLQTKPDYLEVLEKTT 974
++ + L L+AK Q++PDYLEVLEK T
Sbjct: 815 SKPNHPL-LQAKPQSEPDYLEVLEKQT 840
>gi|33504581 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 652 bits (1682), Expect = 0.0
Identities = 358/815 (43%), Positives = 492/815 (60%), Gaps = 66/815 (8%)
Query: 15 LWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITE 74
+W + + T+A I E + + C C CE KE++ +I+C++KGFT +S +
Sbjct: 5 VWFLSVLTVA-----GILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQP 59
Query: 75 FWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHE 134
R ++L+L N + +LY N F++ +NAV+++LGNN LQ+I+TGAF+GLK LKRL+L+
Sbjct: 60 PQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNN 119
Query: 135 NKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFK 194
NKL++ R DTFLGLESLEYLQADYN I IE+GAF L+KL+VLILNDNL+ LP+N+F+
Sbjct: 120 NKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR 179
Query: 195 AVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTA 254
V LTHLDLRGNRLKV+ + G+L+HIG +ME+QLEENPWNCTC+++ LK+WL+ I T
Sbjct: 180 FVLLTHLDLRGNRLKVMPFAGVLEHIG-GIMEIQLEENPWNCTCDLLPLKAWLDTI--TV 236
Query: 255 LVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSML 314
VG+I CETPF HGKD+ ++ + +LCP S S+ +S H+ + + PT
Sbjct: 237 FVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASD--SSQRGSHADTHVQRLSPTM----- 289
Query: 315 SSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQP-------PIAPYQTRP 367
N PT+ P+ RPP P PI YQT+
Sbjct: 290 ---------------NPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKS 334
Query: 368 PIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSD 427
P+P+ CP+ C C +D GL VNC+ER F NIS+L P+P + KKLYL+ N +Q +Y++D
Sbjct: 335 PVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKND 394
Query: 428 FWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYF 487
+SSLDLLHLGNNRI+ +Q+GAF NL +L+ L+LNGN +E L P MF GLQSL YLY
Sbjct: 395 LLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYL 454
Query: 488 EFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGV 547
E+NVI+EI+P F + NL+LLFLNNNLLR+LP + F GT+L RLNLR N+F +LPV GV
Sbjct: 455 EYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGV 514
Query: 548 LEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIEL 607
L+ L A +QIDL ENPWDCTCD++ K W E +S ++ +V C SP ++ +
Sbjct: 515 LDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGR 574
Query: 608 EVLCPEMLHVAPAGESPAQPGDSHLIGAP--TSASPYEFSPPGGPVPLSVLILSLLVLFF 665
E +CP+ +P +H P S SP + VPLSVLIL LLV+F
Sbjct: 575 EAICPD----SPNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFI 630
Query: 666 SAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDGGGGGGGSGGGGRP 725
+V AGLF +VL +RRK +P + +D++ Q+Q G
Sbjct: 631 LSVCFGAGLFVFVL-KRRKGVPSVPRNTNNLDVSSFQLQY-----------------GSY 672
Query: 726 TLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSAERGGPGTQPP 785
+ +K GHVY YIP PV QMC NPIY +E + VA + S + P
Sbjct: 673 NTETHDKTD--GHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQEFSYSNLEEKKEEP 730
Query: 786 GMGEALLGSEQFAE---TPKENHSNYRTLLEKEKE 817
+ + + E TP+E Y+ + E+ KE
Sbjct: 731 ATPAYTISATELLEKQATPREPELLYQNIAERVKE 765
Score = 35.4 bits (80), Expect = 0.26
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 888 ERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQ 947
ER + P + G V + T+PK + P + QD R+ +T+L+ + Q
Sbjct: 761 ERVKELP-SAGLVHYNFCTLPKRQ----FAPSYESRRQNQD-RINKTVLYGTPRKCFVGQ 814
Query: 948 TQKSDYLELRAKLQTKPDYLEVLEKTT 974
++ + L L+AK Q++PDYLEVLEK T
Sbjct: 815 SKPNHPL-LQAKPQSEPDYLEVLEKQT 840
>gi|27436867 slit and trk like 4 protein [Homo sapiens]
Length = 837
Score = 587 bits (1512), Expect = e-167
Identities = 312/675 (46%), Positives = 436/675 (64%), Gaps = 34/675 (5%)
Query: 15 LWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITE 74
LW+ L+ + + T DS+ E C + C C E++ +++C+ +Q+
Sbjct: 3 LWLFLILSALISSTNA-----DSDISVEIC-NVCSCVSVENVLYVNCEKVSVYRPNQLKP 56
Query: 75 FWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHE 134
WS + L Q N + LY N+FL+ ++AVS++LGNN LQ+I+ GAF GL LK+L+L+
Sbjct: 57 PWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNN 116
Query: 135 NKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFK 194
N+L + R DTFLG+E+LEYLQADYN+IK IE GAF L KL+VLILNDNLI LP N+F+
Sbjct: 117 NELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR 176
Query: 195 AVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTA 254
SLTHLD+RGNR++ L Y G+L+HIGR ++ELQLE+NPWNC+C+++ LK+WLE +PY
Sbjct: 177 FASLTHLDIRGNRIQKLPYIGVLEHIGR-VVELQLEDNPWNCSCDLLPLKAWLENMPYNI 235
Query: 255 LVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSML 314
+G+ CETP +G+ L+E K ELCP+ + S+ + + P S EN + T
Sbjct: 236 YIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPP---SQLENGYTTPNG--- 289
Query: 315 SSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGP-----NQPPIAPYQTRPPI 369
H T +S+ ++ K PK T PS + G N I YQTR P
Sbjct: 290 ---HTTQTSL-HRLVTKPPKTTN-------PSKISGIVAGKALSNRNLSQIVSYQTRVPP 338
Query: 370 PIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFW 429
CP C C H +DLGL+VNC+E+ ++SEL+P+PLNAKKL+++ N I+ + SDF
Sbjct: 339 LTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFT 398
Query: 430 NFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEF 489
+F LDLLHLG+N+I+ ++ F NL NL+ L+LNGN IE+L P +F GL +L YLY E+
Sbjct: 399 DFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEY 458
Query: 490 NVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLE 549
N+I+EI F MPNL+LL+LNNNLL++LP F+G LARLNLR N F+YLPV+GVL+
Sbjct: 459 NLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLD 518
Query: 550 HLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIELEV 609
L ++ QIDL NPWDCTCDLV K W+E +S VV ++ C +P + ++++++ E+
Sbjct: 519 QLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEI 578
Query: 610 LCPEMLHVAPAGESPAQPGDSHLIGAPTSASPYEFSPPGGPVPLSVLILSLLVLFFSAVF 669
LCP++L+ A + P I T P SPPGGPVPLS+LILS+LV+ VF
Sbjct: 579 LCPKLLNKPSAPFTSPAPA----ITFTTPLGPIR-SPPGGPVPLSILILSILVVLILTVF 633
Query: 670 VAAGLFAYVLRRRRK 684
VA L +VLRR +K
Sbjct: 634 VAFCLLVFVLRRNKK 648
Score = 47.8 bits (112), Expect = 5e-05
Identities = 24/55 (43%), Positives = 37/55 (67%), Gaps = 1/55 (1%)
Query: 920 MQYPDLQQDARLKETLLFSAGKGFTDHQTQKSDYLELRAKLQTKPDYLEVLEKTT 974
++YP+ Q D + K++L+ Q +KS+Y EL+AKLQ+ PDYL+VLE+ T
Sbjct: 779 IRYPEKQPDKKSKKSLIGGNHSKIVVEQ-RKSEYFELKAKLQSSPDYLQVLEEQT 832
>gi|40217825 slit and trk like 6 [Homo sapiens]
Length = 841
Score = 530 bits (1366), Expect = e-150
Identities = 306/831 (36%), Positives = 465/831 (55%), Gaps = 96/831 (11%)
Query: 15 LWI-----ILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNI 69
LWI LL+ I+L TP+ S C C CE K+ I+C++KG +
Sbjct: 3 LWIHLFYSSLLACISLHSQTPVLSSRGS------CDSLCNCEEKDGTMLINCEAKGIKMV 56
Query: 70 SQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKR 129
S+I+ SRPF+L L N + L+TN F L NA+SI+LG N + DI+ GAFNGL +LK+
Sbjct: 57 SEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQ 116
Query: 130 LYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLP 189
L+++ N L++ + DTF GLE+LE+LQAD N I IE AF L++L+VLILNDN I LP
Sbjct: 117 LHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLP 176
Query: 190 TNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLER 249
N+F+ V LTHLDLRGN+L+ L Y G L+HIGR +++LQLE+N W C C+++QLK+WLE
Sbjct: 177 PNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGR-ILDLQLEDNKWACNCDLLQLKTWLEN 235
Query: 250 IPYTALVGDITCETPFHFHGKDLREIRKTELCPLL----SDSEVEASLGIPHSSSSKENA 305
+P +++GD+ C +P F G L ++K +CP + SL + +SS ++
Sbjct: 236 MPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSR 295
Query: 306 WPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPIAPYQT 365
TK +S+L PTK P + PY T
Sbjct: 296 MSTKTTSILKL------------------PTKAPG-------------------LIPYIT 318
Query: 366 RPPIPI---ICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQK 422
+P + CP C C + ++ GL ++C+ER ++S+L P P N +KL L+ N+I
Sbjct: 319 KPSTQLPGPYCPIPCNCKV-LSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHS 377
Query: 423 IYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSL 482
+ +SD + +L++LHLGNNRI +++G+F+NL L+ L+LNGN + KL+ GMF GL +L
Sbjct: 378 LMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNL 437
Query: 483 HYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYL 542
YLY E+N I+EI P F+ MP LK+L+LNNNLL+ LP F+G L ++NL+ N F +L
Sbjct: 438 EYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHL 497
Query: 543 PVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDV 602
PV+ +L+ L+ + QIDL +NPWDC+CDLV +QWI+ +S +V D+LC SP +L +++
Sbjct: 498 PVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKEL 557
Query: 603 RTIELEVLCPEMLHVAPAGESPAQPGDSHLIGAPTSASPYEFSPP-----GGPVPLSVLI 657
+ + E+LCP +++ +P+ P + + T A+ + VPLSVLI
Sbjct: 558 KALNSEILCPGLVN------NPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLI 611
Query: 658 LSLLVLFFSAVFVAAGLFAYVLRRRRKKLPFRSKR--QEGVDLTGIQMQCHRLFEDGGGG 715
L LL++F + VF AAG+ VL RRR+ ++ K+ ++ D + + +Q
Sbjct: 612 LGLLIMFITIVFCAAGIVVLVLHRRRR---YKKKQVDEQMRDNSPVHLQYSMY------- 661
Query: 716 GGGSGGGGRPTLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSA 775
G T + P +++ P+ + +P + P+ EE + +E A
Sbjct: 662 -------GHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDA 714
Query: 776 ERGGPGTQPPGMGEALLGSEQFAETPKEN---------HSNYRTLLEKEKE 817
+ L GS +T ++ S YR +LEKE+E
Sbjct: 715 KHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERE 765
Score = 48.9 bits (115), Expect = 2e-05
Identities = 24/53 (45%), Positives = 35/53 (66%), Gaps = 1/53 (1%)
Query: 922 YPDLQQDARLKETLLFSAGKGFTDHQTQKSDYLELRAKLQTKPDYLEVLEKTT 974
YP ++ +L ETL++S + QT K++Y EL+A L +PDYLEVLE+ T
Sbjct: 790 YPGAHEELKLMETLMYSRPRKVLVEQT-KNEYFELKANLHAEPDYLEVLEQQT 841
>gi|40217817 slit and trk like 1 protein [Homo sapiens]
Length = 696
Score = 489 bits (1260), Expect = e-138
Identities = 274/705 (38%), Positives = 419/705 (59%), Gaps = 35/705 (4%)
Query: 14 MLWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQIT 73
+LWI+LL T + E+I C C E H+ C+ KGFT++ + T
Sbjct: 2 LLWILLLETSLCFAAGNVTGDVCKEKI-------CSCNEIEGDLHVDCEKKGFTSLQRFT 54
Query: 74 EFWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLH 133
S+ + L+L NS+ +L+ N F + NAVS+++ NN L +I GAF GL+++KRL+++
Sbjct: 55 APTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHIN 114
Query: 134 ENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLF 193
NK+ FR TFLGL+ LEYLQAD+N+++ I+ GAF++L+KL VLILNDNLI LP N+F
Sbjct: 115 NNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVF 174
Query: 194 KAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYT 253
+ V +THLDLRGNRLK L Y +L+ I + E+ LE+NPW+CTC+++ LK WLE IP
Sbjct: 175 QYVPITHLDLRGNRLKTLPYEEVLEQI-PGIAEILLEDNPWDCTCDLLSLKEWLENIPKN 233
Query: 254 ALVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSM 313
AL+G + CE P GKDL E + +LCPL + V++SL P ++E + P
Sbjct: 234 ALIGRVVCEAPTRLQGKDLNETTEQDLCPL--KNRVDSSLPAP---PAQEETFAPGP--- 285
Query: 314 LSSVHFTASSVEYKSSNKQPK-PTKQP---RTPRPPSTSQALYPGPNQPPIAPYQTRPPI 369
L + T ++ + P TK P + P+ + A N+P +
Sbjct: 286 LPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKP------LANSL 339
Query: 370 PIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFW 429
P CP GC+C+ HI GL +NC R +++++L P+ N ++L+L N I I +S F
Sbjct: 340 P--CPGGCSCD-HIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFV 396
Query: 430 NFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEF 489
++ +L LL LGNN I+ V++ F NL +L+ L+++ N ++ L+ F GLQ+L YL E+
Sbjct: 397 DYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEY 456
Query: 490 NVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLE 549
N I+ I P F+ MP L++L LNNNLLR+LP D FAG SL++L+L NYF+YLPVAGVL+
Sbjct: 457 NAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLD 516
Query: 550 HLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIELEV 609
L +I+QIDL+ NPW+C+C +VPFKQW E + S ++ D+ C +P N +D + +
Sbjct: 517 QLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDE 576
Query: 610 LCPEM-LHVAPAGESPAQPGDSHLIGAPTSASPYEFSPPGGPVPLSVLILSLLVLFFSAV 668
+CP++ ++P S ++ + L T ++ Y + V +SVL+ LL++F ++
Sbjct: 577 ICPQLYARISPTLTSHSK-NSTGLAETGTHSNSYLDT---SRVSISVLVPGLLLVFVTSA 632
Query: 669 FVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDGG 713
F G+ ++L R RK+ R ++ +Q C + G
Sbjct: 633 FTVVGMLVFIL-RNRKRSKRRDANSSASEINSLQTVCDSSYWHNG 676
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 115 bits (287), Expect = 3e-25
Identities = 149/611 (24%), Positives = 227/611 (37%), Gaps = 123/611 (20%)
Query: 81 KLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVF 140
+L L+ N++ +L +F L ++NL +NAL + AF GL ++ L L N L V
Sbjct: 138 RLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVL 197
Query: 141 RNDTFLGLESLEYLQADYNVIKRIESGAF---RNLSKL---------------------R 176
+ GL +L L +N ++ + R L++L R
Sbjct: 198 APEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLR 257
Query: 177 VLILNDNLIPMLPTNLFKAVSLTH-LDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWN 235
L+L+ + L F H LDLRGN+L L L G+ L L+L+ NP
Sbjct: 258 ELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTL---PPLQGPGQ-LRRLRLQGNPLW 313
Query: 236 CTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTEL-CPLLSDSEVE---- 290
C C+ L WL R + D C+ P G+ L +R +L CP + E E
Sbjct: 314 CGCQARPLLEWLAR---ARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEE 370
Query: 291 -------ASLGIPHSSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPR 343
A P +E A P + + SS E P+
Sbjct: 371 RAVAGPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGF------- 423
Query: 344 PPSTSQALYPGPNQPPIAPYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISEL 403
PS +Q L N P P P + G +LH+ G+ + + L
Sbjct: 424 -PSDTQLLDLRRNHFPSVPRAAFPGL------GHLVSLHLQHCGIA-ELEAGALAGLGRL 475
Query: 404 LPRPLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFL 463
+ LYLS N + + + L L+L NR V A LP+L SL L
Sbjct: 476 I-------YLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHL 528
Query: 464 NGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDA 523
N +++L PG ++L ++Y N I E+ A L+ L L+ N LR +PT A
Sbjct: 529 QDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGA 588
Query: 524 F---------------------------------------------------AGTSLARL 532
G L L
Sbjct: 589 LEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSL 648
Query: 533 NLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCR 592
+L+KN LP L L+ + IDL+ NP+ C C L+P +W ++ +++ C
Sbjct: 649 HLQKNQLRALP---ALPSLSQLELIDLSSNPFHCDCQLLPLHRW---LTGLNLRVGATCA 702
Query: 593 SPENLTHRDVR 603
+P N + V+
Sbjct: 703 TPPNARGQRVK 713
Score = 64.7 bits (156), Expect = 4e-10
Identities = 58/216 (26%), Positives = 86/216 (39%), Gaps = 32/216 (14%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFS 432
CP C C+ + V C+ + + + +P ++L L NL++ I + F
Sbjct: 33 CPQACICD----NSRRHVACRYQNLTEVPDAIPEL--TQRLDLQGNLLKVIPAAAFQGVP 86
Query: 433 SLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
L L L + + V +GAF L L L L N + +L GL SL L E N +
Sbjct: 87 HLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNAL 146
Query: 493 REIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAG-------------------------T 527
E++P F + L L L +N L LP AF G
Sbjct: 147 EELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLP 206
Query: 528 SLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENP 563
+L RL+L N LP VL + +++L NP
Sbjct: 207 ALRRLSLHHNELQALP-GPVLSQARGLARLELGHNP 241
Score = 64.3 bits (155), Expect = 5e-10
Identities = 55/207 (26%), Positives = 94/207 (45%), Gaps = 11/207 (5%)
Query: 80 FKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDV 139
F L+LQ N++ +L + L N + ++ GA + L++L+L N+L
Sbjct: 524 FSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLRE 583
Query: 140 FRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSK-LRVLILNDNLIPMLPTNLFKAV-- 196
GL +L LQ N ++ + GAF+ + + L+ L LN + + + F +
Sbjct: 584 VPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGP 643
Query: 197 SLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALV 256
L L L+ N+L+ L L L + L NP++C C+++ L WL + V
Sbjct: 644 GLQSLHLQKNQLRALPALPSLS----QLELIDLSSNPFHCDCQLLPLHRWLTGL--NLRV 697
Query: 257 GDITCETPFHFHGKDLREIRKT-ELCP 282
G TC TP + G+ ++ E CP
Sbjct: 698 G-ATCATPPNARGQRVKAAAAVFEDCP 723
Score = 58.5 bits (140), Expect = 3e-08
Identities = 45/139 (32%), Positives = 70/139 (50%), Gaps = 3/139 (2%)
Query: 96 SFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQ 155
+F L + +NL +N L+++ A +GL L+RL L N L+ R TF L +L L
Sbjct: 105 AFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLN 164
Query: 156 ADYNVIKRIESGAFRNLSKLRVLILNDNLIPML-PTNLFKAVSLTHLDLRGNRLKVLFYR 214
+N + + + AF+ L ++R L L+ N + +L P L +L L L N L+ L
Sbjct: 165 LAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQAL--P 222
Query: 215 GMLDHIGRSLMELQLEENP 233
G + R L L+L NP
Sbjct: 223 GPVLSQARGLARLELGHNP 241
Score = 58.5 bits (140), Expect = 3e-08
Identities = 69/244 (28%), Positives = 102/244 (41%), Gaps = 25/244 (10%)
Query: 43 PCFDPCYCEVKESLFHIHCDSKGFTNISQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNN 102
PC C C V ES H C+ G + + F S L L+RN + +F L +
Sbjct: 395 PCPRACVC-VPESR-HSSCEGCGLQAVPR--GFPSDTQLLDLRRNHFPSVPRAAFPGLGH 450
Query: 103 AVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIK 162
VS++L + + +++ GA GL L LYL +N+L G L YL + N
Sbjct: 451 LVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFL 510
Query: 163 RIESGAFRNLSKLRVLILNDNLIPML-PTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIG 221
++ A R L L L L DN + L P +L + +L + L GNR+ + L +G
Sbjct: 511 QVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEV----SLGALG 566
Query: 222 --RSLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTE 279
R L +L L+ N L +P AL G + G LR +R
Sbjct: 567 PARELEKLHLDRNQ-------------LREVPTGALEG-LPALLELQLSGNPLRALRDGA 612
Query: 280 LCPL 283
P+
Sbjct: 613 FQPV 616
Score = 52.8 bits (125), Expect = 2e-06
Identities = 48/170 (28%), Positives = 74/170 (43%), Gaps = 7/170 (4%)
Query: 44 CFDPCYCEVKESLFHIHCDSKGFTNISQ-ITEFWSRPFKLYLQRNSMRKLYTNSFLHLNN 102
C C C+ S H+ C + T + I E R L LQ N ++ + +F + +
Sbjct: 33 CPQACICD--NSRRHVACRYQNLTEVPDAIPELTQR---LDLQGNLLKVIPAAAFQGVPH 87
Query: 103 AVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIK 162
++L + ++ + GAF GL L L L N L + GL SL L+ + N ++
Sbjct: 88 LTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALE 147
Query: 163 RIESGAFRNLSKLRVLILNDNLIPMLPTNLFKA-VSLTHLDLRGNRLKVL 211
+ G F L L L L N + LP F+ + + L L N L VL
Sbjct: 148 ELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVL 197
Score = 40.8 bits (94), Expect = 0.006
Identities = 61/281 (21%), Positives = 94/281 (33%), Gaps = 69/281 (24%)
Query: 398 NNISELLPRPLNA----KKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFI 453
N + EL P A L L+ N + + F + L L +N +S + A
Sbjct: 144 NALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALA 203
Query: 454 NLPNLKSLFLNGNDIEKL------------------TPGMFRG------LQSLHYLYFEF 489
LP L+ L L+ N+++ L P + G L L L +
Sbjct: 204 GLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDG 263
Query: 490 NVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLE 549
++ + P AF+ P L L L N L TLP L+
Sbjct: 264 GALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--------------------------LQ 297
Query: 550 HLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIELEV 609
+ ++ L NP C C P +W ++ V D C+ P R +R L+
Sbjct: 298 GPGQLRRLRLQGNPLWCGCQARPLLEW---LARARVRSDGACQGP-----RRLRGEALDA 349
Query: 610 LCPEMLHVAPAGESPAQPGDSHLIGAPTSASPYEFSPPGGP 650
L P L + + + P +PP GP
Sbjct: 350 LRPWDLRCPGDAAQEEEELEERAVAGPR-------APPRGP 383
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 107 bits (267), Expect = 5e-23
Identities = 72/237 (30%), Positives = 118/237 (49%), Gaps = 10/237 (4%)
Query: 398 NNISELLPRPL----NAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFI 453
N+IS+L P +L L N ++++ F +L L L +N IS + D F
Sbjct: 261 NHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFS 320
Query: 454 NLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNN 513
NL L+ L L+ N I ++PG F GL L L N ++++ F ++ NL+ + L N
Sbjct: 321 NLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQN 380
Query: 514 NLLRTLPTDAFAGTS-LARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVP 572
N LR LP + FA + L + L+ N LP+ G+ +HL + ++ L +NPW C D++P
Sbjct: 381 NRLRQLPGNIFANVNGLMAIQLQNNQLENLPL-GIFDHLGKLCELRLYDNPWRCDSDILP 439
Query: 573 FKQWIETISSVSVVGDV--LCRSPENLTHRDVRTIELEVLCPEMLHVAPAGESPAQP 627
+ W+ ++ + D +C SP N+ + + I + V P +HV P P
Sbjct: 440 LRNWL-LLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPS-VHVPEVPSYPETP 494
Score = 95.9 bits (237), Expect = 2e-19
Identities = 68/191 (35%), Positives = 96/191 (50%), Gaps = 9/191 (4%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFS 432
CP+ CTC+ V C G ++ P P NA L + + I ++ S F N S
Sbjct: 31 CPSECTCSR-----ASQVECT--GARIVAVPTPLPWNAMSLQILNTHITELNESPFLNIS 83
Query: 433 SLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
+L L + N +S + GAF NL +L+ L L N ++ L G+F+GL SL L N +
Sbjct: 84 ALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQL 143
Query: 493 REIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAG-TSLARLNLRKNYFLYLPVAGVLEHL 551
+IQPA FS NLK L L+ N L +P AF L +LNL KN ++ V +HL
Sbjct: 144 LQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHIS-PRVFQHL 202
Query: 552 NAIVQIDLNEN 562
+ + L EN
Sbjct: 203 GNLQVLRLYEN 213
Score = 94.4 bits (233), Expect = 5e-19
Identities = 76/277 (27%), Positives = 125/277 (45%), Gaps = 41/277 (14%)
Query: 81 KLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVF 140
+LYL N + +L + F+ L + L N+L+++ G F + L+ L+L++N +
Sbjct: 255 RLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSL 314
Query: 141 RNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAV-SLT 199
++ F L L+ L N I I GAF L++LR L L+ N + L N+F+ + +L
Sbjct: 315 PDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQ 374
Query: 200 HLDLRGNRLKVL-----------------------FYRGMLDHIGRSLMELQLEENPWNC 236
++ L+ NRL+ L G+ DH+G+ L EL+L +NPW C
Sbjct: 375 NISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGK-LCELRLYDNPWRC 433
Query: 237 TCEIVQLKSW-LERIPYTALVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGI 295
+I+ L++W L P C +P + G+ L I P S+ +
Sbjct: 434 DSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVP---------SVHV 484
Query: 296 PHSSSSKENAW-PTKPS-----SMLSSVHFTASSVEY 326
P S E W P PS S+ S+ T+ +Y
Sbjct: 485 PEVPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDY 521
Score = 66.6 bits (161), Expect = 1e-10
Identities = 47/132 (35%), Positives = 65/132 (49%), Gaps = 1/132 (0%)
Query: 81 KLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVF 140
+L L N + + +F HL +NLG N+L I F L L+ L L+EN+L
Sbjct: 159 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 218
Query: 141 RNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAV-SLT 199
TF GL +L+ L N I + G F N L+ L L++N I LP ++F + L
Sbjct: 219 PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLN 278
Query: 200 HLDLRGNRLKVL 211
L L GN LK L
Sbjct: 279 RLTLFGNSLKEL 290
Score = 65.5 bits (158), Expect = 2e-10
Identities = 49/152 (32%), Positives = 71/152 (46%), Gaps = 2/152 (1%)
Query: 412 KLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKL 471
KL L N + I F + +L +L L NR++ + G F L NL+ L L N I L
Sbjct: 183 KLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLL 242
Query: 472 TPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAG-TSLA 530
+PG+F +L LY N I ++ P+ F +P L L L N L+ L F +L
Sbjct: 243 SPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLR 302
Query: 531 RLNLRKNYFLYLPVAGVLEHLNAIVQIDLNEN 562
L L N+ LP V +L + + L+ N
Sbjct: 303 ELWLYDNHISSLP-DNVFSNLRQLQVLILSRN 333
Score = 65.1 bits (157), Expect = 3e-10
Identities = 50/152 (32%), Positives = 76/152 (50%), Gaps = 3/152 (1%)
Query: 82 LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141
L + + +L + FL+++ +++ + N L I GAF L L+ L L NKL V
Sbjct: 64 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 123
Query: 142 NDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLF-KAVSLTH 200
F GL+SLE L N + +I+ F S L+ L L+ N + +P F V LT
Sbjct: 124 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTK 183
Query: 201 LDLRGNRLKVLFYRGMLDHIGRSLMELQLEEN 232
L+L N L + R + H+G +L L+L EN
Sbjct: 184 LNLGKNSLTHISPR-VFQHLG-NLQVLRLYEN 213
Score = 63.9 bits (154), Expect = 7e-10
Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 6/152 (3%)
Query: 398 NNISELLPRPL-----NAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAF 452
NN ++LP L + + L LSSN + +I + F S+L L L N + Y+ DGAF
Sbjct: 116 NNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAF 175
Query: 453 INLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLN 512
+L L L L N + ++P +F+ L +L L N + +I F + NL+ L L
Sbjct: 176 DHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQ 235
Query: 513 NNLLRTLPTDAFAGT-SLARLNLRKNYFLYLP 543
N + L F +L RL L N+ LP
Sbjct: 236 QNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 267
Score = 61.2 bits (147), Expect = 4e-09
Identities = 45/145 (31%), Positives = 69/145 (47%), Gaps = 5/145 (3%)
Query: 398 NNISELLPRPL----NAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFI 453
N +S + P + + L L++N +Q + F SL+ L L +N++ +Q F
Sbjct: 93 NELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFS 152
Query: 454 NLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNN 513
NLK L L+GN +E + G F L L L N + I P F + NL++L L
Sbjct: 153 QCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYE 212
Query: 514 NLLRTLPTDAFAG-TSLARLNLRKN 537
N L +P F G +L L L++N
Sbjct: 213 NRLTDIPMGTFDGLVNLQELALQQN 237
Score = 58.9 bits (141), Expect = 2e-08
Identities = 47/149 (31%), Positives = 71/149 (47%), Gaps = 3/149 (2%)
Query: 409 NAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDI 468
N K+L L N ++ I F + L L+LG N ++++ F +L NL+ L L N +
Sbjct: 156 NLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 215
Query: 469 EKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAG-T 527
+ G F GL +L L + N I + P F NL+ L+L+NN + LP F
Sbjct: 216 TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLP 275
Query: 528 SLARLNLRKNYF--LYLPVAGVLEHLNAI 554
L RL L N L L + G + +L +
Sbjct: 276 QLNRLTLFGNSLKELSLGIFGPMPNLREL 304
Score = 53.1 bits (126), Expect = 1e-06
Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
Query: 102 NAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVI 161
NA+S+ + N + ++ F + L L + +N+L F L SL YL N +
Sbjct: 60 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 119
Query: 162 KRIESGAFRNLSKLRVLILNDN-LIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHI 220
+ + G F+ L L L+L+ N L+ + P + + +L L L GN L+ + G DH+
Sbjct: 120 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYI-PDGAFDHL 178
Query: 221 GRSLMELQLEEN 232
L +L L +N
Sbjct: 179 -VGLTKLNLGKN 189
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 107 bits (267), Expect = 5e-23
Identities = 72/237 (30%), Positives = 118/237 (49%), Gaps = 10/237 (4%)
Query: 398 NNISELLPRPL----NAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFI 453
N+IS+L P +L L N ++++ F +L L L +N IS + D F
Sbjct: 255 NHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFS 314
Query: 454 NLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNN 513
NL L+ L L+ N I ++PG F GL L L N ++++ F ++ NL+ + L N
Sbjct: 315 NLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQN 374
Query: 514 NLLRTLPTDAFAGTS-LARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVP 572
N LR LP + FA + L + L+ N LP+ G+ +HL + ++ L +NPW C D++P
Sbjct: 375 NRLRQLPGNIFANVNGLMAIQLQNNQLENLPL-GIFDHLGKLCELRLYDNPWRCDSDILP 433
Query: 573 FKQWIETISSVSVVGDV--LCRSPENLTHRDVRTIELEVLCPEMLHVAPAGESPAQP 627
+ W+ ++ + D +C SP N+ + + I + V P +HV P P
Sbjct: 434 LRNWL-LLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPS-VHVPEVPSYPETP 488
Score = 95.9 bits (237), Expect = 2e-19
Identities = 68/191 (35%), Positives = 96/191 (50%), Gaps = 9/191 (4%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFS 432
CP+ CTC+ V C G ++ P P NA L + + I ++ S F N S
Sbjct: 25 CPSECTCSR-----ASQVECT--GARIVAVPTPLPWNAMSLQILNTHITELNESPFLNIS 77
Query: 433 SLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
+L L + N +S + GAF NL +L+ L L N ++ L G+F+GL SL L N +
Sbjct: 78 ALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQL 137
Query: 493 REIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAG-TSLARLNLRKNYFLYLPVAGVLEHL 551
+IQPA FS NLK L L+ N L +P AF L +LNL KN ++ V +HL
Sbjct: 138 LQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHIS-PRVFQHL 196
Query: 552 NAIVQIDLNEN 562
+ + L EN
Sbjct: 197 GNLQVLRLYEN 207
Score = 94.4 bits (233), Expect = 5e-19
Identities = 76/277 (27%), Positives = 125/277 (45%), Gaps = 41/277 (14%)
Query: 81 KLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVF 140
+LYL N + +L + F+ L + L N+L+++ G F + L+ L+L++N +
Sbjct: 249 RLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSL 308
Query: 141 RNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAV-SLT 199
++ F L L+ L N I I GAF L++LR L L+ N + L N+F+ + +L
Sbjct: 309 PDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQ 368
Query: 200 HLDLRGNRLKVL-----------------------FYRGMLDHIGRSLMELQLEENPWNC 236
++ L+ NRL+ L G+ DH+G+ L EL+L +NPW C
Sbjct: 369 NISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGK-LCELRLYDNPWRC 427
Query: 237 TCEIVQLKSW-LERIPYTALVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGI 295
+I+ L++W L P C +P + G+ L I P S+ +
Sbjct: 428 DSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVP---------SVHV 478
Query: 296 PHSSSSKENAW-PTKPS-----SMLSSVHFTASSVEY 326
P S E W P PS S+ S+ T+ +Y
Sbjct: 479 PEVPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDY 515
Score = 66.6 bits (161), Expect = 1e-10
Identities = 47/132 (35%), Positives = 65/132 (49%), Gaps = 1/132 (0%)
Query: 81 KLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVF 140
+L L N + + +F HL +NLG N+L I F L L+ L L+EN+L
Sbjct: 153 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 212
Query: 141 RNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAV-SLT 199
TF GL +L+ L N I + G F N L+ L L++N I LP ++F + L
Sbjct: 213 PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLN 272
Query: 200 HLDLRGNRLKVL 211
L L GN LK L
Sbjct: 273 RLTLFGNSLKEL 284
Score = 65.5 bits (158), Expect = 2e-10
Identities = 49/152 (32%), Positives = 71/152 (46%), Gaps = 2/152 (1%)
Query: 412 KLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKL 471
KL L N + I F + +L +L L NR++ + G F L NL+ L L N I L
Sbjct: 177 KLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLL 236
Query: 472 TPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAG-TSLA 530
+PG+F +L LY N I ++ P+ F +P L L L N L+ L F +L
Sbjct: 237 SPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLR 296
Query: 531 RLNLRKNYFLYLPVAGVLEHLNAIVQIDLNEN 562
L L N+ LP V +L + + L+ N
Sbjct: 297 ELWLYDNHISSLP-DNVFSNLRQLQVLILSRN 327
Score = 65.1 bits (157), Expect = 3e-10
Identities = 50/152 (32%), Positives = 76/152 (50%), Gaps = 3/152 (1%)
Query: 82 LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141
L + + +L + FL+++ +++ + N L I GAF L L+ L L NKL V
Sbjct: 58 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 117
Query: 142 NDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLF-KAVSLTH 200
F GL+SLE L N + +I+ F S L+ L L+ N + +P F V LT
Sbjct: 118 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTK 177
Query: 201 LDLRGNRLKVLFYRGMLDHIGRSLMELQLEEN 232
L+L N L + R + H+G +L L+L EN
Sbjct: 178 LNLGKNSLTHISPR-VFQHLG-NLQVLRLYEN 207
Score = 63.9 bits (154), Expect = 7e-10
Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 6/152 (3%)
Query: 398 NNISELLPRPL-----NAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAF 452
NN ++LP L + + L LSSN + +I + F S+L L L N + Y+ DGAF
Sbjct: 110 NNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAF 169
Query: 453 INLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLN 512
+L L L L N + ++P +F+ L +L L N + +I F + NL+ L L
Sbjct: 170 DHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQ 229
Query: 513 NNLLRTLPTDAFAGT-SLARLNLRKNYFLYLP 543
N + L F +L RL L N+ LP
Sbjct: 230 QNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 261
Score = 61.2 bits (147), Expect = 4e-09
Identities = 45/145 (31%), Positives = 69/145 (47%), Gaps = 5/145 (3%)
Query: 398 NNISELLPRPL----NAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFI 453
N +S + P + + L L++N +Q + F SL+ L L +N++ +Q F
Sbjct: 87 NELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFS 146
Query: 454 NLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNN 513
NLK L L+GN +E + G F L L L N + I P F + NL++L L
Sbjct: 147 QCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYE 206
Query: 514 NLLRTLPTDAFAG-TSLARLNLRKN 537
N L +P F G +L L L++N
Sbjct: 207 NRLTDIPMGTFDGLVNLQELALQQN 231
Score = 58.9 bits (141), Expect = 2e-08
Identities = 47/149 (31%), Positives = 71/149 (47%), Gaps = 3/149 (2%)
Query: 409 NAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDI 468
N K+L L N ++ I F + L L+LG N ++++ F +L NL+ L L N +
Sbjct: 150 NLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 209
Query: 469 EKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAG-T 527
+ G F GL +L L + N I + P F NL+ L+L+NN + LP F
Sbjct: 210 TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLP 269
Query: 528 SLARLNLRKNYF--LYLPVAGVLEHLNAI 554
L RL L N L L + G + +L +
Sbjct: 270 QLNRLTLFGNSLKELSLGIFGPMPNLREL 298
Score = 53.1 bits (126), Expect = 1e-06
Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
Query: 102 NAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVI 161
NA+S+ + N + ++ F + L L + +N+L F L SL YL N +
Sbjct: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 113
Query: 162 KRIESGAFRNLSKLRVLILNDN-LIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHI 220
+ + G F+ L L L+L+ N L+ + P + + +L L L GN L+ + G DH+
Sbjct: 114 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYI-PDGAFDHL 172
Query: 221 GRSLMELQLEEN 232
L +L L +N
Sbjct: 173 -VGLTKLNLGKN 183
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 103 bits (257), Expect = 8e-22
Identities = 73/245 (29%), Positives = 119/245 (48%), Gaps = 30/245 (12%)
Query: 413 LYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLT 472
L LS+N I +I S F + +L L+LG+N ++ V AF L +L+ L L+ N IE +
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
Query: 473 PGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFA------- 525
P F+GL +L YL + + IR + FS + NLK L L++N L L +D F+
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
Query: 526 -------------------GTSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDC 566
G SL LNL N L VL+ L++++ + N NPW+C
Sbjct: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALH-PRVLKPLSSLIHLQANSNPWEC 363
Query: 567 TCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIELEVLCPEMLHVAPAGESPAQ 626
C L+ + W ++S ++ ++ C++P ++ R +R I + ++V+ A
Sbjct: 364 NCKLLGLRDW---LASSAITLNIYCQNPPSMRGRALRYINITNCVTSSINVSRAWAVVKS 420
Query: 627 PGDSH 631
P H
Sbjct: 421 PHIHH 425
Score = 91.3 bits (225), Expect = 4e-18
Identities = 63/222 (28%), Positives = 105/222 (47%), Gaps = 29/222 (13%)
Query: 82 LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141
L L N++ ++ + F HL N + LG+N L + + AF LK L+RL L N ++ +
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
Query: 142 NDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAV-SLTH 200
F GL +LEYL + I+ + F ++ L+ LIL+ N + L ++ F + +L +
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
Query: 201 LDLRGNRLKVLFYRGMLDHIG------------------------RSLMELQLEENPWNC 236
L L NR+ + +++G SL+ LQ NPW C
Sbjct: 305 LKLDRNRI-ISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWEC 363
Query: 237 TCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKT 278
C+++ L+ WL +A+ +I C+ P G+ LR I T
Sbjct: 364 NCKLLGLRDWLAS---SAITLNIYCQNPPSMRGRALRYINIT 402
Score = 90.9 bits (224), Expect = 5e-18
Identities = 59/177 (33%), Positives = 93/177 (52%), Gaps = 4/177 (2%)
Query: 387 GLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISY 446
G +NC+ G ++I + P + LYL+ N I I S+ SL L+L N+ I Y
Sbjct: 41 GRQINCRNLGLSSIPKNFPE--STVFLYLTGNNISYINESELTGLHSLVALYLDNSNILY 98
Query: 447 VQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNL 506
V AF+ L +L LFLN N I++L PG+F+GL +L LY ++N + + F+ + ++
Sbjct: 99 VYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSV 158
Query: 507 KLLFLNNNLLRTLPTDAFAG-TSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNEN 562
+ L L N L L + F G +L L+L N L + +G +HL + + L N
Sbjct: 159 QYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESG-FQHLENLACLYLGSN 214
Score = 64.7 bits (156), Expect = 4e-10
Identities = 41/131 (31%), Positives = 66/131 (50%), Gaps = 1/131 (0%)
Query: 82 LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141
L+L N +++L F L N ++ L N + + G FN L ++ L L N+L V
Sbjct: 113 LFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLG 172
Query: 142 NDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAV-SLTH 200
+ TF+G+ +L L N I RI F++L L L L N + +P+N F+ + SL
Sbjct: 173 SGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRR 232
Query: 201 LDLRGNRLKVL 211
L L N ++ +
Sbjct: 233 LSLSHNPIEAI 243
Score = 61.2 bits (147), Expect = 4e-09
Identities = 42/126 (33%), Positives = 68/126 (53%), Gaps = 1/126 (0%)
Query: 413 LYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLT 472
L+L++N I+++ F +L L+L N++S+V G F +L +++ L L N + L
Sbjct: 113 LFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLG 172
Query: 473 PGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAF-AGTSLAR 531
G F G+ +L L N I I + F + NL L+L +N L +P++AF SL R
Sbjct: 173 SGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRR 232
Query: 532 LNLRKN 537
L+L N
Sbjct: 233 LSLSHN 238
Score = 54.7 bits (130), Expect = 4e-07
Identities = 37/111 (33%), Positives = 55/111 (49%), Gaps = 1/111 (0%)
Query: 102 NAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVI 161
+ V + L N + I GL L LYL + + F+ L L +L + N I
Sbjct: 61 STVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFI 120
Query: 162 KRIESGAFRNLSKLRVLILNDNLIPMLPTNLFK-AVSLTHLDLRGNRLKVL 211
KR++ G F+ L LR L L N + +P +F VS+ +L+L+ NRL VL
Sbjct: 121 KRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVL 171
Score = 51.2 bits (121), Expect = 5e-06
Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 1/129 (0%)
Query: 82 LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141
LYLQ N + + F L + +NL N L + +G F G+ L+ L L N +
Sbjct: 137 LYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRIS 196
Query: 142 NDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAV-SLTH 200
F LE+L L N + ++ S AF L LR L L+ N I + FK + +L +
Sbjct: 197 ESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEY 256
Query: 201 LDLRGNRLK 209
L L+ +R++
Sbjct: 257 LLLKNSRIR 265
>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
Length = 420
Score = 101 bits (252), Expect = 3e-21
Identities = 70/234 (29%), Positives = 114/234 (48%), Gaps = 28/234 (11%)
Query: 75 FWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNA-LQDIQTGAFNGLKILKRLYLH 133
F S L+L N++ +Y +F HL ++LG+N L+ ++ F GL+ L+ L+L+
Sbjct: 80 FGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLY 139
Query: 134 ENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLF 193
+L + F GL SL+YL N + ++ F +L+ L L L+ N + +L ++F
Sbjct: 140 RCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVF 199
Query: 194 KAV-SLTHLDLRGNRLK----------------VLFYRGMLDHIGRSLME------LQLE 230
+ + SL L L GNRL+ LF + G +L + L+L
Sbjct: 200 RGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLN 259
Query: 231 ENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTEL--CP 282
NPW C C L +W +R ++ D+TC TP G+DLR +R+ + CP
Sbjct: 260 ANPWACDCRARPLWAWFQRARVSS--SDVTCATPPERQGRDLRALREADFQACP 311
Score = 101 bits (251), Expect = 4e-21
Identities = 93/316 (29%), Positives = 128/316 (40%), Gaps = 53/316 (16%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLP----------------RP----LNAKK 412
CP CTC TV+C+ F+++ LP RP N
Sbjct: 31 CPMLCTCY----SSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLT 86
Query: 413 LYLSSNLIQKIYRSDFWNFSSLDLLHLGNNR-ISYVQDGAFINLPNLKSLFLNGNDIEKL 471
L+L SN + IY F + +L+ L LG+NR + ++ F L L+SL L + L
Sbjct: 87 LWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSL 146
Query: 472 TPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGT-SLA 530
+FRGL SL YLY + N + +Q F+ + NL LFL+ N LR L F G SL
Sbjct: 147 PGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLD 206
Query: 531 RLNLRKN----------------YFLYL------PVAG-VLEHLNAIVQIDLNENPWDCT 567
RL L N LYL + G L L ++ + LN NPW C
Sbjct: 207 RLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACD 266
Query: 568 CDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIELE--VLCPEMLHVAPAGESPA 625
C P W + S DV C +P RD+R + CP P +
Sbjct: 267 CRARPLWAWFQRARVSS--SDVTCATPPERQGRDLRALREADFQACPPAAPTRPGSRARG 324
Query: 626 QPGDSHLIGAPTSASP 641
+HL G + +P
Sbjct: 325 NSSSNHLYGVAEAGAP 340
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 100 bits (248), Expect = 9e-21
Identities = 108/417 (25%), Positives = 167/417 (40%), Gaps = 51/417 (12%)
Query: 81 KLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVF 140
+L L RN++ ++ F L N ++L +N + I+ GAF LK L+RL L++NKL V
Sbjct: 65 RLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVL 124
Query: 141 RNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAV-SLT 199
F L L N I+ I AFR ++ ++ L L++N I + F+A+ L
Sbjct: 125 PELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLE 184
Query: 200 HLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDI 259
L L N + + +H+ + + L+L N C C + L WL + VG
Sbjct: 185 ILTLNNNNISRILVTS-FNHMPK-IRTLRLHSNHLYCDCHLAWLSDWLRQ---RRTVGQF 239
Query: 260 T-CETPFHFHGKDLREIRKTE-LCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSMLSSV 317
T C P H G ++ +++K E +CP PHS NA S S
Sbjct: 240 TLCMAPVHLRGFNVADVQKKEYVCP------------APHSEPPSCNA---NSISCPSPC 284
Query: 318 HFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPIAPYQTRPPIPIICPTGC 377
+ + V+ + P P Q Y+ I I
Sbjct: 285 TCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDI------ 338
Query: 378 TCNLHINDLGLTVNCKERGFNNISELLPRPLNAKK----LYLSSNLIQKIYRSDFWNFSS 433
N IS++ P K L L N I +I + F S
Sbjct: 339 ------------------SKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVS 380
Query: 434 LDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFN 490
L LL L N+I+ ++ F +L NL L L N ++ ++ G+F LQS+ L+ N
Sbjct: 381 LQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQN 437
Score = 99.4 bits (246), Expect = 1e-20
Identities = 82/275 (29%), Positives = 128/275 (46%), Gaps = 18/275 (6%)
Query: 368 PIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSD 427
P + CPT CTC+ +V+C G + +PR NA++L L N I +I + D
Sbjct: 29 PPAVACPTKCTCS------AASVDCHGLGLRAVPRGIPR--NAERLDLDRNNITRITKMD 80
Query: 428 FWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYF 487
F +L +LHL +N++S ++ GAF +L L+ L LN N ++ L +F+ L L
Sbjct: 81 FAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDL 140
Query: 488 EFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAF-AGTSLARLNLRKNYFLYLPVAG 546
N I+ I AF + ++K L L+NN + + AF A L L L N + V
Sbjct: 141 SENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTS 200
Query: 547 VLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIE 606
H+ I + L+ N C C L W+ +V LC +P +L +V ++
Sbjct: 201 -FNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQF--TLCMAPVHLRGFNVADVQ 257
Query: 607 -LEVLCPEMLHVAPAGESPAQPGDSHLIGAPTSAS 640
E +CP AP E P+ +S +P + S
Sbjct: 258 KKEYVCP-----APHSEPPSCNANSISCPSPCTCS 287
Score = 82.8 bits (203), Expect = 1e-15
Identities = 66/236 (27%), Positives = 104/236 (44%), Gaps = 34/236 (14%)
Query: 371 IICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWN 430
I CP+ CTC+ +I V+C+ +G I LP + ++ L N I+ I F
Sbjct: 278 ISCPSPCTCSNNI------VDCRGKGLMEIPANLPEGI--VEIRLEQNSIKAIPAGAFTQ 329
Query: 431 FSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFN 490
+ L + + N+IS + AF L +L SL L GN I ++ G+F GL SL L N
Sbjct: 330 YKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNAN 389
Query: 491 VIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEH 550
I ++ F + NL LL L +N L+T+ FA
Sbjct: 390 KINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAP------------------------ 425
Query: 551 LNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIE 606
L +I + L +NP+ C C L +++ + + G C SP L ++ + I+
Sbjct: 426 LQSIQTLHLAQNPFVCDCHLKWLADYLQD-NPIETSG-ARCSSPRRLANKRISQIK 479
Score = 82.0 bits (201), Expect = 2e-15
Identities = 113/477 (23%), Positives = 187/477 (39%), Gaps = 93/477 (19%)
Query: 149 ESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAV-SLTHLDLRGNR 207
E + ++ + N IK I +GAF KL+ + ++ N I + + F+ + SLT L L GN+
Sbjct: 307 EGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNK 366
Query: 208 LKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHF 267
+ + +G+ D + SL L L N N C V L+ + +L D +T
Sbjct: 367 ITEIA-KGLFDGLV-SLQLLLLNANKIN--CLRVNTFQDLQNLNLLSLY-DNKLQTISKG 421
Query: 268 HGKDLREIRKTEL--------CPL------LSDSEVEASLGIPHSSSSKENAWPTKPSSM 313
L+ I+ L C L L D+ +E S + S K S
Sbjct: 422 LFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETS----GARCSSPRRLANKRISQ 477
Query: 314 LSSVHFTAS-SVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPIAPYQTRPPIPII 372
+ S F S S +Y+S + + + ++
Sbjct: 478 IKSKKFRCSGSEDYRSR---------------------------------FSSECFMDLV 504
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSD-FWNF 431
CP C C G V+C + I LP + L L+ N + + + F
Sbjct: 505 CPEKCRCE------GTIVDCSNQKLVRIPSHLPEYVT--DLRLNDNEVSVLEATGIFKKL 556
Query: 432 SSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNV 491
+L ++L NN+I V++GAF +++ L L GN +E + +FRGL
Sbjct: 557 PNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLS----------- 605
Query: 492 IREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHL 551
LK L L +NL+ + D FAG S RL + + G L
Sbjct: 606 -------------GLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTL 652
Query: 552 NAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIELE 608
++ I+L NP++C C L +W+ VS G+ C+ P L ++ + ++
Sbjct: 653 VSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVS--GNPRCQKPFFLKEIPIQDVAIQ 707
Score = 80.1 bits (196), Expect = 9e-15
Identities = 105/432 (24%), Positives = 164/432 (37%), Gaps = 76/432 (17%)
Query: 40 IDEPCFDPCYCEVKESLFHIHCDSKGFTNI-SQITEFWSRPFKLYLQRNSMRKLY-TNSF 97
+D C + C CE + C ++ I S + E+ + L L N + L T F
Sbjct: 501 MDLVCPEKCRCEGTI----VDCSNQKLVRIPSHLPEYVT---DLRLNDNEVSVLEATGIF 553
Query: 98 LHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQAD 157
L N INL NN +++++ GAF+G ++ L L N+L+ F GL L+ L
Sbjct: 554 KKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLR 613
Query: 158 YNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGML 217
N+I + + F LS +R+L L DN I + F +
Sbjct: 614 SNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLV-------------------- 653
Query: 218 DHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRK 277
SL + L NP+NC C + L WL + + G+ C+ PF ++++
Sbjct: 654 -----SLSTINLLSNPFNCNCHLAWLGKWLRK--RRIVSGNPRCQKPFFLKEIPIQDVAI 706
Query: 278 TEL-CPLLSDSEVEASLGIPHSSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPT 336
+ C +S + S P + E + SNK +
Sbjct: 707 QDFTCDGNEESSCQLSPRCPEQCTCMETV--------------------VRCSNKGLRAL 746
Query: 337 KQPRTPRPPSTSQALYPGPNQPPIAPYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERG 396
PR P LY N P + + +L N + + N
Sbjct: 747 --PR--GMPKDVTELYLEGNHLTAVPRELSALRHL-----TLIDLSNNSISMLTNYT--- 794
Query: 397 FNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLP 456
F+N+S L L LS N ++ I F SL +L L N IS V +G+F +L
Sbjct: 795 FSNMSHL-------STLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLT 847
Query: 457 NLKSLFLNGNDI 468
+L L L N +
Sbjct: 848 SLSHLALGTNPL 859
Score = 72.0 bits (175), Expect = 3e-12
Identities = 58/233 (24%), Positives = 92/233 (39%), Gaps = 33/233 (14%)
Query: 44 CFDPCYCEVKESLFHIHCDSKGFTNISQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNA 103
C PC C S + C KG I ++ L++NS++ + +F
Sbjct: 280 CPSPCTC----SNNIVDCRGKGLMEIP--ANLPEGIVEIRLEQNSIKAIPAGAFTQYKKL 333
Query: 104 VSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKR 163
I++ N + DI AF GLK L L L+ NK+ F GL SL+ L + N I
Sbjct: 334 KRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINC 393
Query: 164 IESGAFRNLSKLRVLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRS 223
+ F++L L +L L DN + + LF + +S
Sbjct: 394 LRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPL-------------------------QS 428
Query: 224 LMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIR 276
+ L L +NP+ C C + L +L+ P C +P K + +I+
Sbjct: 429 IQTLHLAQNPFVCDCHLKWLADYLQDNPIE--TSGARCSSPRRLANKRISQIK 479
Score = 58.2 bits (139), Expect = 4e-08
Identities = 41/144 (28%), Positives = 66/144 (45%), Gaps = 9/144 (6%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFS 432
CP CTC + V C +G + +P+ + +LYL N + + R +
Sbjct: 725 CPEQCTC------METVVRCSNKGLRALPRGMPKDVT--ELYLEGNHLTAVPR-ELSALR 775
Query: 433 SLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
L L+ L NN IS + + F N+ +L +L L+ N + + F GL+SL L N I
Sbjct: 776 HLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDI 835
Query: 493 REIQPAAFSLMPNLKLLFLNNNLL 516
+ +F+ + +L L L N L
Sbjct: 836 SSVPEGSFNDLTSLSHLALGTNPL 859
Score = 53.9 bits (128), Expect = 7e-07
Identities = 43/145 (29%), Positives = 63/145 (43%), Gaps = 5/145 (3%)
Query: 457 NLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLL 516
++ L+L GN + + P L+ L + N I + FS M +L L L+ N L
Sbjct: 753 DVTELYLEGNHLTAV-PRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRL 811
Query: 517 RTLPTDAFAGT-SLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQ 575
R +P AF G SL L L N +P G L ++ + L NP C C L +
Sbjct: 812 RCIPVHAFNGLRSLRVLTLHGNDISSVP-EGSFNDLTSLSHLALGTNPLHCDCSLRWLSE 870
Query: 576 WIETISSVSVVGDVLCRSPENLTHR 600
W++ + G C SPE + R
Sbjct: 871 WVK--AGYKEPGIARCSSPEPMADR 893
Score = 46.6 bits (109), Expect = 1e-04
Identities = 37/125 (29%), Positives = 56/125 (44%), Gaps = 4/125 (3%)
Query: 125 KILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNL 184
K + LYL N L + L L + N I + + F N+S L LIL+ N
Sbjct: 752 KDVTELYLEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNR 810
Query: 185 IPMLPTNLFKAV-SLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQL 243
+ +P + F + SL L L GN + + G + + SL L L NP +C C + L
Sbjct: 811 LRCIPVHAFNGLRSLRVLTLHGNDISSV-PEGSFNDL-TSLSHLALGTNPLHCDCSLRWL 868
Query: 244 KSWLE 248
W++
Sbjct: 869 SEWVK 873
Score = 46.2 bits (108), Expect = 1e-04
Identities = 41/154 (26%), Positives = 66/154 (42%), Gaps = 17/154 (11%)
Query: 35 EDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQ-----ITEFWSRPFKLYLQRNSM 89
E S ++ C + C C E++ + C +KG + + +TE LYL+ N +
Sbjct: 716 ESSCQLSPRCPEQCTC--METV--VRCSNKGLRALPRGMPKDVTE-------LYLEGNHL 764
Query: 90 RKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLE 149
+ L + I+L NN++ + F+ + L L L N+L F GL
Sbjct: 765 TAV-PRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLR 823
Query: 150 SLEYLQADYNVIKRIESGAFRNLSKLRVLILNDN 183
SL L N I + G+F +L+ L L L N
Sbjct: 824 SLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTN 857
>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
sapiens]
Length = 345
Score = 97.4 bits (241), Expect = 6e-20
Identities = 82/260 (31%), Positives = 126/260 (48%), Gaps = 34/260 (13%)
Query: 44 CFDPCYCEVKESLFHIHCDSKGFTNISQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNA 103
C D CYC+ S + C +G I +R L+LQ N + L +F +
Sbjct: 21 CPDKCYCQ--SSTNFVDCSQQGLAEIPSHLPPQTRT--LHLQDNQIHHLPAFAFRSVPWL 76
Query: 104 VSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKR 163
+++NL NN+L ++ GAF+GL+ L+ L L +N L
Sbjct: 77 MTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSL------------------------LS 112
Query: 164 IESGAFRNLSKLRVLILNDNLIPMLPTNLFKA-VSLTHLDLRGNRLKVLFYRGMLDHIGR 222
+ES F +L +LR L L+ N I LPT+L + +LT L ++ N+L+ L R +L+ +
Sbjct: 113 LESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQL-DRALLESM-P 170
Query: 223 SLMELQLEENPWNCTCEIVQLKSWLERIPYT-ALVGDITCETPFHFHGKDLREI--RKTE 279
S+ L L++N W C C ++ LK WLE+ Y L I CE+P + GKDL I +
Sbjct: 171 SVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQ 230
Query: 280 LCPLLSDSEVEASLGIPHSS 299
CPL + V + P S+
Sbjct: 231 PCPLPAPDPVSSQAQWPGSA 250
Score = 89.7 bits (221), Expect = 1e-17
Identities = 72/262 (27%), Positives = 113/262 (43%), Gaps = 34/262 (12%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFS 432
CP C C N V+C ++G I LP
Sbjct: 21 CPDKCYCQSSTN----FVDCSQQGLAEIPSHLPPQTRT---------------------- 54
Query: 433 SLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
LHL +N+I ++ AF ++P L +L L+ N + L PG F GLQ L L N +
Sbjct: 55 ----LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSL 110
Query: 493 REIQPAAFSLMPNLKLLFLNNNLLRTLPTD-AFAGTSLARLNLRKNYFLYLPVAGVLEHL 551
++ F +P L+ L L++N + LPT +L L +++N L A +LE +
Sbjct: 111 LSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRA-LLESM 169
Query: 552 NAIVQIDLNENPWDCTCDLVPFKQWIET-ISSVSVVGDVLCRSPENLTHRDVRTIELEVL 610
++ + L +N W C C L+ K W+E + + ++C SP+ +D+ I E+
Sbjct: 170 PSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELY 229
Query: 611 CPEMLHVAPAGESPAQ-PGDSH 631
P L S AQ PG +H
Sbjct: 230 QPCPLPAPDPVSSQAQWPGSAH 251
>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
Length = 473
Score = 97.1 bits (240), Expect = 7e-20
Identities = 88/319 (27%), Positives = 135/319 (42%), Gaps = 57/319 (17%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGF------------------NNISELLPRPLNAKK-- 412
CP C C N+ +T +C ++G N IS + A +
Sbjct: 27 CPGACVC---YNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNL 83
Query: 413 --LYLSSNLIQKIYRSDFWNFSSLDLLHLGNN-RISYVQDGAFINLPNLKSLFLNGNDIE 469
L+L SN++ +I + F + L+ L L +N ++ V F L L +L L+ ++
Sbjct: 84 TILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQ 143
Query: 470 KLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGT-S 528
+L PG+FRGL +L YLY + N ++ + F + NL LFL+ N + ++P AF G S
Sbjct: 144 ELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHS 203
Query: 529 LARLNLRKN----------------YFLYLPVAGV-------LEHLNAIVQIDLNENPWD 565
L RL L +N LYL + L L A+ + LN+NPW
Sbjct: 204 LDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWV 263
Query: 566 CTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIELEVLCPEMLHVAPAGESPA 625
C C P W++ S +V C P+ L RD++ + L + VA P
Sbjct: 264 CDCRARPLWAWLQKFRGSS--SEVPCSLPQRLAGRDLKRLAANDL--QGCAVATGPYHPI 319
Query: 626 QPG---DSHLIGAPTSASP 641
G D +G P P
Sbjct: 320 WTGRATDEEPLGLPKCCQP 338
Score = 84.7 bits (208), Expect = 4e-16
Identities = 63/221 (28%), Positives = 104/221 (47%), Gaps = 13/221 (5%)
Query: 62 DSKGFTNISQITEFWSRPFKLYLQRNS-MRKLYTNSFLHLNNAVSINLGNNALQDIQTGA 120
D+ FT ++ + + L L N+ +R + +F L +++L LQ++ G
Sbjct: 97 DAAAFTGLALLEQ-------LDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGL 149
Query: 121 FNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLIL 180
F GL L+ LYL +N L +DTF L +L +L N I + AFR L L L+L
Sbjct: 150 FRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLL 209
Query: 181 NDNLIPMLPTNLFKAVS-LTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCE 239
+ N + + + F+ + L L L N L L + R+L L+L +NPW C C
Sbjct: 210 HQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPL--RALQYLRLNDNPWVCDCR 267
Query: 240 IVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTEL 280
L +WL++ + ++ C P G+DL+ + +L
Sbjct: 268 ARPLWAWLQK--FRGSSSEVPCSLPQRLAGRDLKRLAANDL 306
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 96.7 bits (239), Expect = 1e-19
Identities = 115/440 (26%), Positives = 165/440 (37%), Gaps = 109/440 (24%)
Query: 81 KLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVF 140
+L L N++ ++ F L + + L N + I+ GAF LK L+RL L+ N L +F
Sbjct: 59 RLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLF 118
Query: 141 RNDTFLGLESL------------------------EYLQADYNVIKRIESGAFRNLSKLR 176
FLG L + LQ DYN I IE GAFR L L
Sbjct: 119 PELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLE 178
Query: 177 VLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNC 236
VL LN+N I L S H+ L +L N C
Sbjct: 179 VLTLNNNNITRL-----SVASFNHMP--------------------KLRTFRLHSNNLYC 213
Query: 237 TCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIP 296
C + L WL + P L C P H G ++ E++K E S + S +
Sbjct: 214 DCHLAWLSDWLRQRPRVGLY--TQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVL 271
Query: 297 HSSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRT----PRPPSTSQALY 352
H P++ S + V+ + PT P T +T + +
Sbjct: 272 HC-----------PAACTCSNNI----VDCRGKGLTEIPTNLPETITEIRLEQNTIKVIP 316
Query: 353 PGPNQPPIAPYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLP------R 406
PG +PY+ I + N ISEL P R
Sbjct: 317 PG----AFSPYKKLRRIDL------------------------SNNQISELAPDAFQGLR 348
Query: 407 PLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGN 466
LN+ LY N I ++ +S F SL LL L N+I+ ++ AF +L NL L L N
Sbjct: 349 SLNSLVLY--GNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDN 406
Query: 467 DIEKLTPGMF---RGLQSLH 483
++ + G F R +Q++H
Sbjct: 407 KLQTIAKGTFSPLRAIQTMH 426
Score = 87.0 bits (214), Expect = 8e-17
Identities = 109/472 (23%), Positives = 190/472 (40%), Gaps = 75/472 (15%)
Query: 149 ESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAV-SLTHLDLRGNR 207
E++ ++ + N IK I GAF KLR + L++N I L + F+ + SL L L GN+
Sbjct: 300 ETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNK 359
Query: 208 LKVL---FYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETP 264
+ L + G+ SL L L N NC V L + +L D +T
Sbjct: 360 ITELPKSLFEGLF-----SLQLLLLNANKINCLR--VDAFQDLHNLNLLSLY-DNKLQTI 411
Query: 265 FHFHGKDLREIRKTELC--PLLSDSEVEASLGIPHSSSSKEN-AWPTKPSSMLSSVHFTA 321
LR I+ L P + D ++ H++ + + A T P + +
Sbjct: 412 AKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQI 471
Query: 322 SSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPIAPYQTRPP----IPIICPTGC 377
S +++ S K+ Q PG Y+++ + CP C
Sbjct: 472 KSKKFRCSAKE----------------QYFIPGTED-----YRSKLSGDCFADLACPEKC 510
Query: 378 TCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSD-FWNFSSLDL 436
C G TV+C + N I E +P+ +L L++N + + F L
Sbjct: 511 RCE------GTTVDCSNQKLNKIPEHIPQ--YTAELRLNNNEFTVLEATGIFKKLPQLRK 562
Query: 437 LHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQ 496
++ NN+I+ +++GAF + + L N +E + MF+GL+S
Sbjct: 563 INFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLES--------------- 607
Query: 497 PAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLNAIVQ 556
LK L L +N + + D+F G S RL + + G + L+++
Sbjct: 608 ---------LKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLST 658
Query: 557 IDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIELE 608
++L NP++C C L +W+ V G+ C+ P L ++ + ++
Sbjct: 659 LNLLANPFNCNCYLAWLGEWLR--KKRIVTGNPRCQKPYFLKEIPIQDVAIQ 708
Score = 86.7 bits (213), Expect = 1e-16
Identities = 69/238 (28%), Positives = 106/238 (44%), Gaps = 12/238 (5%)
Query: 370 PIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFW 429
P CP C+C+ G TV+C ++ +PR N ++L L+ N I +I ++DF
Sbjct: 25 PQACPAQCSCS------GSTVDCHGLALRSVPRNIPR--NTERLDLNGNNITRITKTDFA 76
Query: 430 NFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEF 489
L +L L N+IS ++ GAF +L L+ L LN N ++ +F G L+ L
Sbjct: 77 GLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSE 136
Query: 490 NVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAF-AGTSLARLNLRKNYFLYLPVAGVL 548
N I+ I AF ++K L L+ N + + AF A L L L N L VA
Sbjct: 137 NQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVAS-F 195
Query: 549 EHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIE 606
H+ + L+ N C C L W+ V + C P +L +V ++
Sbjct: 196 NHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLY--TQCMGPSHLRGHNVAEVQ 251
Score = 86.3 bits (212), Expect = 1e-16
Identities = 69/234 (29%), Positives = 102/234 (43%), Gaps = 34/234 (14%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFS 432
CP CTC+ +I V+C+ +G I LP + ++ L N I+ I F +
Sbjct: 273 CPAACTCSNNI------VDCRGKGLTEIPTNLPETIT--EIRLEQNTIKVIPPGAFSPYK 324
Query: 433 SLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
L + L NN+IS + AF L +L SL L GN I +L +F GL SL L N I
Sbjct: 325 KLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKI 384
Query: 493 REIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLN 552
++ AF + NL LL L +N L+T+ G L
Sbjct: 385 NCLRVDAFQDLHNLNLLSLYDNKLQTI------------------------AKGTFSPLR 420
Query: 553 AIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIE 606
AI + L +NP+ C C L ++ T + + G C SP L ++ + I+
Sbjct: 421 AIQTMHLAQNPFICDCHLKWLADYLHT-NPIETSG-ARCTSPRRLANKRIGQIK 472
Score = 84.7 bits (208), Expect = 4e-16
Identities = 109/433 (25%), Positives = 167/433 (38%), Gaps = 79/433 (18%)
Query: 41 DEPCFDPCYCEVKESLFHIHCDSKGFTNISQITEFWSRPFKLYLQRNSMRKLY-TNSFLH 99
D C + C CE + C ++ I + ++ +L L N L T F
Sbjct: 503 DLACPEKCRCEGTT----VDCSNQKLNKIPEHIPQYTA--ELRLNNNEFTVLEATGIFKK 556
Query: 100 LNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYN 159
L IN NN + DI+ GAF G + + L N+L+ ++ F GLESL+ L N
Sbjct: 557 LPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSN 616
Query: 160 VIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDH 219
I + + +F LS +R+L L DN I + F +
Sbjct: 617 RITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTL----------------------- 653
Query: 220 IGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTE 279
SL L L NP+NC C + L WL + + G+ C+ P+ L+EI +
Sbjct: 654 --HSLSTLNLLANPFNCNCYLAWLGEWLRK--KRIVTGNPRCQKPYF-----LKEIPIQD 704
Query: 280 LCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQP 339
++ + G +S S + PT+ T + SNK K +
Sbjct: 705 ----VAIQDFTCDDGNDDNSCSPLSRCPTE---------CTCLDTVVRCSNKGLKVLPK- 750
Query: 340 RTPRPPSTSQALYPGPNQPPIAPYQTRPPIPIICPTGCTCNLHINDLGLTVN----CKER 395
P LY NQ + P + + H+ + L+ N +
Sbjct: 751 ---GIPRDVTELYLDGNQFTLVPKE------------LSNYKHLTLIDLSNNRISTLSNQ 795
Query: 396 GFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINL 455
F+N+++LL L LS N ++ I F SL LL L N IS V +GAF +L
Sbjct: 796 SFSNMTQLL-------TLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDL 848
Query: 456 PNLKSLFLNGNDI 468
L L + N +
Sbjct: 849 SALSHLAIGANPL 861
Score = 68.2 bits (165), Expect = 4e-11
Identities = 54/230 (23%), Positives = 93/230 (40%), Gaps = 31/230 (13%)
Query: 47 PCYCEVKESLFHIHCDSKGFTNISQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSI 106
P C ++ + C KG T I T ++ L++N+++ + +F I
Sbjct: 274 PAACTCSNNI--VDCRGKGLTEIP--TNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRI 329
Query: 107 NLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIES 166
+L NN + ++ AF GL+ L L L+ NK+ F GL SL+ L + N I +
Sbjct: 330 DLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRV 389
Query: 167 GAFRNLSKLRVLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLME 226
AF++L L +L L DN + + F + R++
Sbjct: 390 DAFQDLHNLNLLSLYDNKLQTIAKGTFSPL-------------------------RAIQT 424
Query: 227 LQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIR 276
+ L +NP+ C C + L +L P C +P K + +I+
Sbjct: 425 MHLAQNPFICDCHLKWLADYLHTNPIE--TSGARCTSPRRLANKRIGQIK 472
Score = 67.8 bits (164), Expect = 5e-11
Identities = 46/144 (31%), Positives = 70/144 (48%), Gaps = 9/144 (6%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFS 432
CPT CTC L V C +G + + +PR + +LYL N + + + N+
Sbjct: 727 CPTECTC------LDTVVRCSNKGLKVLPKGIPRDVT--ELYLDGNQFTLVPK-ELSNYK 777
Query: 433 SLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
L L+ L NNRIS + + +F N+ L +L L+ N + + P F GL+SL L N I
Sbjct: 778 HLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDI 837
Query: 493 REIQPAAFSLMPNLKLLFLNNNLL 516
+ AF+ + L L + N L
Sbjct: 838 SVVPEGAFNDLSALSHLAIGANPL 861
Score = 48.9 bits (115), Expect = 2e-05
Identities = 39/145 (26%), Positives = 61/145 (42%), Gaps = 5/145 (3%)
Query: 457 NLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLL 516
++ L+L+GN L P + L + N I + +FS M L L L+ N L
Sbjct: 755 DVTELYLDGNQFT-LVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRL 813
Query: 517 RTLPTDAFAG-TSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQ 575
R +P F G SL L+L N +P G L+A+ + + NP C C++
Sbjct: 814 RCIPPRTFDGLKSLRLLSLHGNDISVVP-EGAFNDLSALSHLAIGANPLYCDCNMQWLSD 872
Query: 576 WIETISSVSVVGDVLCRSPENLTHR 600
W++ S G C P + +
Sbjct: 873 WVK--SEYKEPGIARCAGPGEMADK 895
Score = 43.9 bits (102), Expect = 7e-04
Identities = 36/135 (26%), Positives = 62/135 (45%), Gaps = 12/135 (8%)
Query: 123 GLKILKR--------LYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSK 174
GLK+L + LYL N+ + + + L + N I + + +F N+++
Sbjct: 744 GLKVLPKGIPRDVTELYLDGNQFTLVPKE-LSNYKHLTLIDLSNNRISTLSNQSFSNMTQ 802
Query: 175 LRVLILNDNLIPMLPTNLFKAV-SLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENP 233
L LIL+ N + +P F + SL L L GN + V+ G + + +L L + NP
Sbjct: 803 LLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV-PEGAFNDLS-ALSHLAIGANP 860
Query: 234 WNCTCEIVQLKSWLE 248
C C + L W++
Sbjct: 861 LYCDCNMQWLSDWVK 875
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 95.9 bits (237), Expect = 2e-19
Identities = 69/239 (28%), Positives = 105/239 (43%), Gaps = 34/239 (14%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFS 432
CP+ C C TV C + + P+ L L N I++I F
Sbjct: 36 CPSRCLC------FRTTVRCMHLLLEAVPAVAPQ---TSILDLRFNRIREIQPGAFRRLR 86
Query: 433 SLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
+L+ L L NN+I + GAF +L NLK L+L N+I+ + F+GL SL LY FN I
Sbjct: 87 NLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQI 146
Query: 493 REIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLN 552
+ P +F +P L+ LFL+NN + L V G HL
Sbjct: 147 ETLDPDSFQHLPKLERLFLHNNRITHL------------------------VPGTFNHLE 182
Query: 553 AIVQIDLNENPWDCTCDLVPFKQWIETIS-SVSVVGDVLCRSPENLTHRDVRTIELEVL 610
++ ++ L+ N C C+++ ++T + S + +C P + R V TI E L
Sbjct: 183 SMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEEL 241
Score = 82.0 bits (201), Expect = 2e-15
Identities = 60/200 (30%), Positives = 95/200 (47%), Gaps = 26/200 (13%)
Query: 82 LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141
L L+ N +R++ +F L N ++ L NN ++ I +GAF L+ LK LYL++N++
Sbjct: 67 LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126
Query: 142 NDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAVSLTHL 201
F GL SLE L +N I+ ++ +F++L KL L L++N I THL
Sbjct: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRI-------------THL 173
Query: 202 DLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTA-LVGDIT 260
G +H+ S+ L+L+ N +C CEI+ L L+ +
Sbjct: 174 -----------VPGTFNHL-ESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAI 221
Query: 261 CETPFHFHGKDLREIRKTEL 280
CE P G+ + I EL
Sbjct: 222 CEYPRRIQGRSVATITPEEL 241
Score = 39.3 bits (90), Expect = 0.018
Identities = 22/57 (38%), Positives = 30/57 (52%)
Query: 81 KLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKL 137
+LYL N + L +SF HL + L NN + + G FN L+ +KRL L N L
Sbjct: 138 QLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTL 194
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 95.9 bits (237), Expect = 2e-19
Identities = 111/445 (24%), Positives = 176/445 (39%), Gaps = 67/445 (15%)
Query: 47 PCYCEVKESLFHIHCDSKGFTNI-SQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNAVS 105
P C + + C KG T I + + E + ++ L+ N ++ + +F
Sbjct: 283 PAMCTCSNGI--VDCRGKGLTAIPANLPETMT---EIRLELNGIKSIPPGAFSPYRKLRR 337
Query: 106 INLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIE 165
I+L NN + +I AF GL+ L L L+ NK+ F GL +L+ L + N I I
Sbjct: 338 IDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIR 397
Query: 166 SGAFRNLSKLRVLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLM 225
AF++L L +L L DN I L F ++ R++
Sbjct: 398 PDAFQDLQNLSLLSLYDNKIQSLAKGTFTSL-------------------------RAIQ 432
Query: 226 ELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTELCPLLS 285
L L +NP+ C C + L +L P C +P K + +I+ +
Sbjct: 433 TLHLAQNPFICDCNLKWLADFLRTNPIE--TSGARCASPRRLANKRIGQIKSKKF----- 485
Query: 286 DSEVEASLGIPHSSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPP 345
+ IP + + N+ A+ VE S K TK P R P
Sbjct: 486 RCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSL----KLTKIPE--RIP 539
Query: 346 STSQALYPGPNQPPIAPYQTRPPIPIICPTGCTCNL-HINDLGLTVNCKERGFNNISEL- 403
++ L N+ I I+ TG L H+ + L+ N +SE+
Sbjct: 540 QSTAELRLNNNE-----------ISILEATGMFKKLTHLKKINLS-------NNKVSEIE 581
Query: 404 ---LPRPLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKS 460
+ +L+L++N ++ I F L L L NNRIS + + +F L N++
Sbjct: 582 DGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRL 641
Query: 461 LFLNGNDIEKLTPGMFRGLQSLHYL 485
L L N I ++PG F LQSL L
Sbjct: 642 LSLYDNQITTVSPGAFDTLQSLSTL 666
Score = 95.1 bits (235), Expect = 3e-19
Identities = 71/235 (30%), Positives = 109/235 (46%), Gaps = 12/235 (5%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFS 432
CP CTC G TV+C G I + +PR N ++L L+ N I +I+++DF
Sbjct: 34 CPALCTCT------GTTVDCHGTGLQAIPKNIPR--NTERLELNGNNITRIHKNDFAGLK 85
Query: 433 SLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
L +L L N+I V+ GAF ++ L+ L LN N + L +F+ Q+L L N I
Sbjct: 86 QLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAI 145
Query: 493 REIQPAAFSLMPNLKLLFLNNNLLRTLPTDAF-AGTSLARLNLRKNYFLYLPVAGVLEHL 551
+ I AF +LK L L+ N + + AF A L L L N +PV+ H+
Sbjct: 146 QAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSS-FNHM 204
Query: 552 NAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIE 606
+ L+ N C C L QW+ ++ + C P +L +V ++
Sbjct: 205 PKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLF--TQCSGPASLRGLNVAEVQ 257
Score = 87.4 bits (215), Expect = 6e-17
Identities = 116/474 (24%), Positives = 178/474 (37%), Gaps = 113/474 (23%)
Query: 81 KLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDV- 139
+L L N++ +++ N F L + L N + ++ GAF+ +K L+RL L+ N+L +
Sbjct: 65 RLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHML 124
Query: 140 ----FRND-------------------TFLGLESLEYLQADYNVIKRIESGAFRNLSKLR 176
F+N+ F G L+ LQ D N I IE GAFR L L
Sbjct: 125 PELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLE 184
Query: 177 VLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNC 236
VL LN+N I +P + F +H+ + L +L N C
Sbjct: 185 VLTLNNNNITTIPVSSF------------------------NHMPK-LRTFRLHSNHLFC 219
Query: 237 TCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIP 296
C + L WL + P L C P G ++ E++K+E
Sbjct: 220 DCHLAWLSQWLRQRPTIGLF--TQCSGPASLRGLNVAEVQKSEF---------------- 261
Query: 297 HSSSSKENAWPTKPSSMLSSVHFTA------SSVEYKSSNKQPKPTKQPRTPRPPSTS-- 348
S S + P+ LSS A V+ + P P T
Sbjct: 262 --SCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELN 319
Query: 349 --QALYPGPNQPPIAPYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPR 406
+++ PG +PY+ I +L N + +G +++ L+
Sbjct: 320 GIKSIPPG----AFSPYRKLRRI----------DLSNNQIAEIAPDAFQGLRSLNSLV-- 363
Query: 407 PLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGN 466
L N I + R F +L LL L N+I+ ++ AF +L NL L L N
Sbjct: 364 --------LYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDN 415
Query: 467 DIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLL--FLNNNLLRT 518
I+ L G F L+++ L+ N F NLK L FL N + T
Sbjct: 416 KIQSLAKGTFTSLRAIQTLHLAQN--------PFICDCNLKWLADFLRTNPIET 461
Score = 87.0 bits (214), Expect = 8e-17
Identities = 109/431 (25%), Positives = 164/431 (38%), Gaps = 75/431 (17%)
Query: 41 DEPCFDPCYCEVKESLFHIHCDSKGFTNISQITEFWSRPFKLYLQRNSMRKLY-TNSFLH 99
D C C CE + C S T I + +L L N + L T F
Sbjct: 510 DVVCPHKCRCEANV----VECSSLKLTKIPE--RIPQSTAELRLNNNEISILEATGMFKK 563
Query: 100 LNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYN 159
L + INL NN + +I+ GAF G + L+L N+L+ R+ F GL+ L L N
Sbjct: 564 LTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNN 623
Query: 160 VIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDH 219
I I + +F L +R+L L DN I + F +
Sbjct: 624 RISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTL----------------------- 660
Query: 220 IGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTE 279
+SL L L NP+NC C++ L WL + + G+ C+ P L+++ +
Sbjct: 661 --QSLSTLNLLANPFNCNCQLAWLGGWLRK--RKIVTGNPRCQNPDFLRQIPLQDVAFPD 716
Query: 280 LCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQP 339
+ E +P +E A L +V + SNK + +
Sbjct: 717 ---FRCEEGQEEGGCLPRPQCPQECA-------CLDTV--------VRCSNKHLRALPK- 757
Query: 340 RTPRPPSTSQALYPGPNQPPIAPYQ--TRPPIPIICPTGCTCNLHINDLGLTVNCKERGF 397
P LY NQ + P Q T + ++ +L N + N F
Sbjct: 758 ---GIPKNVTELYLDGNQFTLVPGQLSTFKYLQLV-------DLSNNKISSLSN---SSF 804
Query: 398 NNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPN 457
N+S+L L LS N +Q I F SL LL L N IS +Q+G F ++ +
Sbjct: 805 TNMSQL-------TTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTS 857
Query: 458 LKSLFLNGNDI 468
L L + N +
Sbjct: 858 LSHLAIGANPL 868
Score = 85.1 bits (209), Expect = 3e-16
Identities = 70/234 (29%), Positives = 103/234 (44%), Gaps = 34/234 (14%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFS 432
CP CTC+ I V+C+ +G I LP + +L L N I+ I F +
Sbjct: 282 CPAMCTCSNGI------VDCRGKGLTAIPANLPETMTEIRLEL--NGIKSIPPGAFSPYR 333
Query: 433 SLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
L + L NN+I+ + AF L +L SL L GN I L G+F GL +L L N I
Sbjct: 334 KLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKI 393
Query: 493 REIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLN 552
I+P AF + NL LL L +N +++L F L
Sbjct: 394 NCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTS------------------------LR 429
Query: 553 AIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIE 606
AI + L +NP+ C C+L ++ T + + G C SP L ++ + I+
Sbjct: 430 AIQTLHLAQNPFICDCNLKWLADFLRT-NPIETSG-ARCASPRRLANKRIGQIK 481
Score = 84.3 bits (207), Expect = 5e-16
Identities = 60/228 (26%), Positives = 103/228 (45%), Gaps = 35/228 (15%)
Query: 371 IICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSD-FW 429
++CP C C ++ V C I E +P+ + +L L++N I + + F
Sbjct: 511 VVCPHKCRCEANV------VECSSLKLTKIPERIPQ--STAELRLNNNEISILEATGMFK 562
Query: 430 NFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEF 489
+ L ++L NN++S ++DGAF ++ L L N +E + GMFRGL L L
Sbjct: 563 KLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRN 622
Query: 490 NVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLE 549
N I I +F+ + N++LL L +N + T+ AF +
Sbjct: 623 NRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAF------------------------D 658
Query: 550 HLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENL 597
L ++ ++L NP++C C L W+ V G+ C++P+ L
Sbjct: 659 TLQSLSTLNLLANPFNCNCQLAWLGGWLR--KRKIVTGNPRCQNPDFL 704
Score = 61.6 bits (148), Expect = 3e-09
Identities = 42/144 (29%), Positives = 67/144 (46%), Gaps = 9/144 (6%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFS 432
CP C C L V C + + + +P+ N +LYL N + F
Sbjct: 734 CPQECAC------LDTVVRCSNKHLRALPKGIPK--NVTELYLDGNQFTLV-PGQLSTFK 784
Query: 433 SLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
L L+ L NN+IS + + +F N+ L +L L+ N ++ + P F+GL+SL L N I
Sbjct: 785 YLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDI 844
Query: 493 REIQPAAFSLMPNLKLLFLNNNLL 516
+Q F+ + +L L + N L
Sbjct: 845 STLQEGIFADVTSLSHLAIGANPL 868
Score = 55.5 bits (132), Expect = 2e-07
Identities = 40/113 (35%), Positives = 60/113 (53%), Gaps = 9/113 (7%)
Query: 128 KRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPM 187
+RL L+ N + + F GL+ L LQ N I +E GAF ++ +L L LN N + M
Sbjct: 64 ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHM 123
Query: 188 LPTNLFK-AVSLTHLDLRGNRLKVL---FYRGMLDHIGRSLMELQLEENPWNC 236
LP LF+ +L+ LDL N ++ + +RG D L LQL++N +C
Sbjct: 124 LPELLFQNNQALSRLDLSENAIQAIPRKAFRGATD-----LKNLQLDKNQISC 171
Score = 52.4 bits (124), Expect = 2e-06
Identities = 39/142 (27%), Positives = 63/142 (44%), Gaps = 5/142 (3%)
Query: 457 NLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLL 516
N+ L+L+GN L PG + L + N I + ++F+ M L L L+ N L
Sbjct: 762 NVTELYLDGNQFT-LVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNAL 820
Query: 517 RTLPTDAFAGT-SLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQ 575
+ +P AF G SL L+L N L G+ + ++ + + NP C C L
Sbjct: 821 QCIPPLAFQGLRSLRLLSLHGNDISTLQ-EGIFADVTSLSHLAIGANPLYCDCHLRWLSS 879
Query: 576 WIETISSVSVVGDVLCRSPENL 597
W++T G C P+++
Sbjct: 880 WVKT--GYKEPGIARCAGPQDM 899
Score = 49.7 bits (117), Expect = 1e-05
Identities = 39/128 (30%), Positives = 61/128 (47%), Gaps = 10/128 (7%)
Query: 125 KILKRLYLHENKLDVFRNDTFLGLESLEYLQA---DYNVIKRIESGAFRNLSKLRVLILN 181
K + LYL N+ + L + +YLQ N I + + +F N+S+L LIL+
Sbjct: 761 KNVTELYLDGNQFTLVPGQ----LSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILS 816
Query: 182 DNLIPMLPTNLFKAV-SLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEI 240
N + +P F+ + SL L L GN + L G+ + SL L + NP C C +
Sbjct: 817 YNALQCIPPLAFQGLRSLRLLSLHGNDISTL-QEGIFADV-TSLSHLAIGANPLYCDCHL 874
Query: 241 VQLKSWLE 248
L SW++
Sbjct: 875 RWLSSWVK 882
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 95.1 bits (235), Expect = 3e-19
Identities = 67/192 (34%), Positives = 96/192 (50%), Gaps = 6/192 (3%)
Query: 372 ICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNF 431
ICP C C I L C ++G + + R +L L+ N + I R DF N
Sbjct: 19 ICPKRCVCQ--ILSPNLATLCAKKGLLFVPPNIDR--RTVELRLADNFVTNIKRKDFANM 74
Query: 432 SSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNV 491
+SL L L N IS++ AF +L NL++L LN N + K+T MF GL +LH+L N
Sbjct: 75 TSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQ 134
Query: 492 IREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAG-TSLARLNLRKNYFLYLPVAGVLEH 550
+ I AF + L+ L L+ N L T+P DA SL L+L N +P G H
Sbjct: 135 LTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIP-KGTFSH 193
Query: 551 LNAIVQIDLNEN 562
L+ + ++D+ N
Sbjct: 194 LHKMTRLDVTSN 205
Score = 75.1 bits (183), Expect = 3e-13
Identities = 67/236 (28%), Positives = 110/236 (46%), Gaps = 28/236 (11%)
Query: 64 KGFTNISQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNG 123
K F N++ + + L L RN++ + ++F L N +++L +N L I F+G
Sbjct: 69 KDFANMTSLVD-------LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSG 121
Query: 124 LKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDN 183
L L L L+ N+L + + F + +LE L YN ++ I A + L L L+ N
Sbjct: 122 LSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHN 181
Query: 184 LIPMLPTNLFKAV-SLTHLDLRGNRLK-----VLFYRGML----DHIGRSLMELQLEENP 233
+I +P F + +T LD+ N+L+ LF R + I S L NP
Sbjct: 182 MIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNP 241
Query: 234 WNCTCEIVQLKSWLERIPYTALVGDI-TCETPFHFHGKDLREIRKTE-LC--PLLS 285
+C CE++ WL R+ + D+ TC +P G+ I + E LC PL++
Sbjct: 242 LHCNCELL----WLRRL---SREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLIT 290
Score = 65.1 bits (157), Expect = 3e-10
Identities = 60/219 (27%), Positives = 97/219 (44%), Gaps = 24/219 (10%)
Query: 398 NNISELLPRPL----NAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFI 453
N IS + P N + L+L+SN + KI F S+L L L NN+++ + AF
Sbjct: 85 NTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFD 144
Query: 454 NLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNN 513
++ L+ L L+ N++E + + SLH L + N+I I FS + + L + +
Sbjct: 145 DVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTS 204
Query: 514 NLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPF 573
N L+ LP D + L +G++ + + NP C C+L+
Sbjct: 205 NKLQKLPPDPLFQRAQV-----------LATSGIIS--PSTFALSFGGNPLHCNCELL-- 249
Query: 574 KQWIETISSVSVVGDVLCRSPENLTHRDVRTI-ELEVLC 611
W+ +S + C SP LT R +I E E LC
Sbjct: 250 --WLRRLSREDDL--ETCASPPLLTGRYFWSIPEEEFLC 284
>gi|191252816 extracellular leucine-rich repeat and fibronectin type
III domain containing 1 [Homo sapiens]
Length = 828
Score = 92.8 bits (229), Expect = 1e-18
Identities = 71/249 (28%), Positives = 118/249 (47%), Gaps = 45/249 (18%)
Query: 402 ELLPRPLNAK--KLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLK 459
E +P+ +N+ L L+ N I+ + + F +L L+L N I Y++DGAF NL+
Sbjct: 52 EAIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQ 111
Query: 460 SLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTL 519
L L N + LT GM RGL L YLY + N+I + ++F PN+ + L+ N ++ L
Sbjct: 112 VLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQL 171
Query: 520 PTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIET 579
+ FAG LA+L++ +L NP+ C+C+L+ F +W+
Sbjct: 172 NSGTFAG--LAKLSV----------------------CELYSNPFYCSCELLGFLRWLAA 207
Query: 580 ISSVSVVGD-VLCRSPENLT-----------HRDVRTIELEVLCPEMLHVAPAGESP--- 624
++ + D + C SP + HR + + +L+ +C E + A P
Sbjct: 208 FTNATQTYDRMQCESPPVYSGYYLLGQGRRGHRSILS-KLQSVCTEDSYAAEVVGPPRPA 266
Query: 625 ---AQPGDS 630
+QPG S
Sbjct: 267 SGRSQPGRS 275
Score = 68.6 bits (166), Expect = 3e-11
Identities = 61/264 (23%), Positives = 108/264 (40%), Gaps = 20/264 (7%)
Query: 104 VSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKR 163
V + L N ++ +Q + + L L L +N++ + F G +L+ LQ YN ++
Sbjct: 63 VDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRN 122
Query: 164 IESGAFRNLSKLRVLILNDNLIP-MLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGR 222
+ G R L KL L L NLI ++ ++ ++ ++ ++DL NR++ L G + +
Sbjct: 123 LTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQL-NSGTFAGLAK 181
Query: 223 SLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGD-ITCETPFHFHGKDLREIRKTELC 281
L +L NP+ C+CE++ WL D + CE+P + G L +
Sbjct: 182 -LSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLLGQGRRGHR 240
Query: 282 PLLSDSEVEASLGIPHSSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRT 341
+LS + + S + E P +P+S S + P P P
Sbjct: 241 SILSKLQSVCT----EDSYAAEVVGPPRPASGRS------------QPGRSPPPPPPPEP 284
Query: 342 PRPPSTSQALYPGPNQPPIAPYQT 365
P + G P+ T
Sbjct: 285 SDMPCADDECFSGDGTTPLVALPT 308
Score = 47.4 bits (111), Expect = 7e-05
Identities = 30/102 (29%), Positives = 49/102 (48%)
Query: 82 LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141
L L +N + + +F N + LG N L+++ G GL L+ LYL N ++V
Sbjct: 89 LNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVM 148
Query: 142 NDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDN 183
+F ++ + N I+++ SG F L+KL V L N
Sbjct: 149 ASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCELYSN 190
>gi|116268101 leucine rich repeat containing 62 [Homo sapiens]
Length = 820
Score = 92.8 bits (229), Expect = 1e-18
Identities = 61/196 (31%), Positives = 97/196 (49%), Gaps = 27/196 (13%)
Query: 402 ELLPRPLNAK--KLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLK 459
E +P+ +N+ L L+ N ++ + S F +L L+L N ISY++DGAF+ +L+
Sbjct: 47 ETIPQHINSTVHDLRLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQ 106
Query: 460 SLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTL 519
L L N + LT GM RG+ L +L+ + N+I + P AFS P+L + L++N L L
Sbjct: 107 VLQLGYNKLSNLTEGMLRGMSRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRL 166
Query: 520 PTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIET 579
FA L +++ +L NP++C CDL F W+
Sbjct: 167 DGATFAS------------------------LASLMVCELAGNPFNCECDLFGFLAWLVV 202
Query: 580 ISSVSVVGDVL-CRSP 594
++V+ D L C SP
Sbjct: 203 FNNVTKNYDRLQCESP 218
Score = 81.3 bits (199), Expect = 4e-15
Identities = 57/177 (32%), Positives = 85/177 (48%), Gaps = 5/177 (2%)
Query: 99 HLNNAV-SINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQAD 157
H+N+ V + L N L+ + + N L L L +N++ + FLG SL+ LQ
Sbjct: 52 HINSTVHDLRLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLG 111
Query: 158 YNVIKRIESGAFRNLSKLRVLILNDNLIPML-PTNLFKAVSLTHLDLRGNRLKVLFYRGM 216
YN + + G R +S+L+ L + NLI ++ PT + SL +DL NRL L G
Sbjct: 112 YNKLSNLTEGMLRGMSRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRL--DGA 169
Query: 217 LDHIGRSLMELQLEENPWNCTCEIVQLKSWLERI-PYTALVGDITCETPFHFHGKDL 272
SLM +L NP+NC C++ +WL T + CE+P F G L
Sbjct: 170 TFASLASLMVCELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQCESPREFAGYPL 226
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 92.0 bits (227), Expect = 2e-18
Identities = 75/238 (31%), Positives = 114/238 (47%), Gaps = 11/238 (4%)
Query: 55 SLFHIHCDSKGFTNISQIT-EFWSRPF---KLYLQRNSMRKLYTNSFLHLNNAVSINLGN 110
SL + DS NIS++ + +S+ F +L+LQRN++ L + F L N ++L
Sbjct: 218 SLQELFLDSN---NISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQW 274
Query: 111 NALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFR 170
N L+ + G F L L L N+L+ TF L +L L YN I + +G FR
Sbjct: 275 NMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFR 334
Query: 171 NLSKLRVLILNDNLIPMLPTNLFKAVS-LTHLDLRGNRLKVLFYRGMLDHIGRSLMELQL 229
+L +L L L N + L LF+ +S L L L N+L L G+ D +L L L
Sbjct: 335 DLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTL-PEGIFD-TNYNLFNLAL 392
Query: 230 EENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTEL-CPLLSD 286
NPW C C + L +WL++ L C P + G+ + + + +L CP+ D
Sbjct: 393 HGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVCPVTRD 450
Score = 80.5 bits (197), Expect = 7e-15
Identities = 68/244 (27%), Positives = 102/244 (41%), Gaps = 53/244 (21%)
Query: 398 NNISELLPRPLNA----KKLYLSSNLIQKIYRSDFWNFSSLDLLHLG------------- 440
NNISEL P+ + ++L+L N I + S F + +L L L
Sbjct: 227 NNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFA 286
Query: 441 -----------NNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEF 489
+N++ V +G F +L NL+SL L+ N I L G+FR L+ L LY
Sbjct: 287 HTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGS 346
Query: 490 NVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLE 549
N + + PA F + L+LL L+ N L TLP F NY L+
Sbjct: 347 NNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIF----------DTNYNLF-------- 388
Query: 550 HLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTI-ELE 608
+ L+ NPW C C L W++ + + C P L + V + E +
Sbjct: 389 ------NLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQ 442
Query: 609 VLCP 612
++CP
Sbjct: 443 LVCP 446
Score = 76.6 bits (187), Expect = 1e-13
Identities = 58/170 (34%), Positives = 85/170 (50%), Gaps = 7/170 (4%)
Query: 399 NISELLPRPL-----NAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFI 453
N + LPR L + K L L+ NL+ ++ F +SL L L NN +S + G F
Sbjct: 155 NQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFG 214
Query: 454 NLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNN 513
L +L+ LFL+ N+I +L P +F L L L+ + N I + + F+ + NL L L
Sbjct: 215 KLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQW 274
Query: 514 NLLRTLPTDAFAGT-SLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNEN 562
N+LR LP FA T L L+L N L G HL+ + + L+ N
Sbjct: 275 NMLRVLPAGLFAHTPCLVGLSLTHNQ-LETVAEGTFAHLSNLRSLMLSYN 323
Score = 59.7 bits (143), Expect = 1e-08
Identities = 52/154 (33%), Positives = 72/154 (46%), Gaps = 6/154 (3%)
Query: 82 LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141
L+LQ N ++ L F L + ++NL N L + F+ L L+ L L N L
Sbjct: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP 209
Query: 142 NDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAV-SLTH 200
F L SL+ L D N I + F L L L L N I LP ++F ++ +LT
Sbjct: 210 QGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTF 269
Query: 201 LDLRGNRLKVLFYRGMLDH----IGRSLMELQLE 230
L L+ N L+VL G+ H +G SL QLE
Sbjct: 270 LSLQWNMLRVL-PAGLFAHTPCLVGLSLTHNQLE 302
Score = 55.8 bits (133), Expect = 2e-07
Identities = 46/147 (31%), Positives = 65/147 (44%), Gaps = 4/147 (2%)
Query: 82 LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141
L L +N + +L F L + ++ L NNAL + G F L L+ L+L N +
Sbjct: 174 LNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELP 233
Query: 142 NDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLF-KAVSLTH 200
F L LE L N I + F +L L L L N++ +LP LF L
Sbjct: 234 PQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVG 293
Query: 201 LDLRGNRLKVLFYRGMLDHIG--RSLM 225
L L N+L+ + G H+ RSLM
Sbjct: 294 LSLTHNQLETV-AEGTFAHLSNLRSLM 319
Score = 54.7 bits (130), Expect = 4e-07
Identities = 48/179 (26%), Positives = 76/179 (42%), Gaps = 11/179 (6%)
Query: 366 RPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYR 425
RP P CP GC C + V C + + +P P +++ ++ R
Sbjct: 17 RPAQP--CPMGCDCFVQ------EVFCSDEELATVPLDIP-PYTKNIIFVETSFTTLETR 67
Query: 426 SDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYL 485
+ F + +L + N ++ + AF LP L+ L + G+ L+ +F L SL L
Sbjct: 68 A-FGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKL 126
Query: 486 YFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAG-TSLARLNLRKNYFLYLP 543
FN++ + F + L+ L L N L+ LP F T L LNL +N LP
Sbjct: 127 TLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185
Score = 53.9 bits (128), Expect = 7e-07
Identities = 39/117 (33%), Positives = 57/117 (48%), Gaps = 1/117 (0%)
Query: 428 FWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYF 487
F N +SL L L N + + +G F +L L+SL L GN ++ L +F+ L L L
Sbjct: 117 FSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNL 176
Query: 488 EFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGT-SLARLNLRKNYFLYLP 543
N++ ++ F + +L+ L L+NN L LP F SL L L N LP
Sbjct: 177 AQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELP 233
Score = 52.8 bits (125), Expect = 2e-06
Identities = 38/126 (30%), Positives = 59/126 (46%), Gaps = 1/126 (0%)
Query: 87 NSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFL 146
+S L TN F +L + + L N L+ + G F L L+ L+L N+L F
Sbjct: 107 SSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQ 166
Query: 147 GLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLF-KAVSLTHLDLRG 205
L L+ L N++ ++ F L+ L+ L L++N + LP +F K SL L L
Sbjct: 167 PLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDS 226
Query: 206 NRLKVL 211
N + L
Sbjct: 227 NNISEL 232
Score = 49.3 bits (116), Expect = 2e-05
Identities = 53/207 (25%), Positives = 87/207 (42%), Gaps = 13/207 (6%)
Query: 27 WTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITEFWSRPFKLYLQR 86
WT+ + L ++ PC C C V+E + C + + +++ +
Sbjct: 9 WTSLLLLARPAQ----PCPMGCDCFVQE----VFCSDEELATVPLDIPPYTK--NIIFVE 58
Query: 87 NSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFL 146
S L T +F N + N L + AF GL L+ L + + + F
Sbjct: 59 TSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFS 118
Query: 147 GLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAVS-LTHLDLRG 205
L SL L ++N+++ + G F++L+ L L L N + LP LF+ ++ L L+L
Sbjct: 119 NLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQ 178
Query: 206 NRLKVLFYRGMLDHIGRSLMELQLEEN 232
N L L L H SL L+L N
Sbjct: 179 NLLAQL--PEELFHPLTSLQTLKLSNN 203
>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
sapiens]
Length = 370
Score = 91.7 bits (226), Expect = 3e-18
Identities = 68/205 (33%), Positives = 95/205 (46%), Gaps = 6/205 (2%)
Query: 110 NNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAF 169
NN L + + AF L L+RL L N LD F L +L LQ N I+ ++
Sbjct: 77 NNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLL 136
Query: 170 RNLSKLRVLILNDNLIPMLPTNLFKAV-SLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQ 228
R+ LR L L+ N + LP LF + +L L LR NRL+ L R + + +L LQ
Sbjct: 137 RHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLD-RLTFEPLA-NLQLLQ 194
Query: 229 LEENPWNCTCEIVQLKSWLERIPYT-ALVGDITCETPFHFHGKDLREI--RKTELCPLLS 285
+ +NPW C C + + K W+E Y + + C P GKD+R + C L
Sbjct: 195 VGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQLE 254
Query: 286 DSEVEASLGIPHSSSSKENAWPTKP 310
D A L IP +K + P KP
Sbjct: 255 DENSSAGLDIPGPPCTKASPEPAKP 279
Score = 84.7 bits (208), Expect = 4e-16
Identities = 75/282 (26%), Positives = 110/282 (39%), Gaps = 37/282 (13%)
Query: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFS 432
CP C C+ L V+C G + +P + L L +N + + F N S
Sbjct: 39 CPFSCKCDSR----SLEVDCSGLGLTTVPPDVPAA--TRTLLLLNNKLSALPSWAFANLS 92
Query: 433 SLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
SL L L NN + + F +L NL L L N I L + R L +L N +
Sbjct: 93 SLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGL 152
Query: 493 REIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLN 552
++ P F + L+ L L +N L+ L D LA L L
Sbjct: 153 AQLPPGLFDGLLALRSLSLRSNRLQNL--DRLTFEPLANLQL------------------ 192
Query: 553 AIVQIDLNENPWDCTCDLVPFKQWIETIS-SVSVVGDVLCRSPENLTHRDVRTIELEVLC 611
+ + +NPW+C C+L FK W+E S + + C P+ L +D+R + +
Sbjct: 193 ----LQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPM---- 244
Query: 612 PEMLHVAPAGESPAQPGDSHLIGAP-TSASPYEFSPPGGPVP 652
EM + E + G P T ASP P G P
Sbjct: 245 -EMFNYCSQLEDENSSAGLDIPGPPCTKASPEPAKPKPGAEP 285
Score = 39.3 bits (90), Expect = 0.018
Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 7/94 (7%)
Query: 66 FTNISQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLK 125
F +++ +TE L L+ NS+R L + H ++L N L + G F+GL
Sbjct: 112 FGDLTNLTE-------LQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLL 164
Query: 126 ILKRLYLHENKLDVFRNDTFLGLESLEYLQADYN 159
L+ L L N+L TF L +L+ LQ N
Sbjct: 165 ALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDN 198
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.138 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,258,423
Number of Sequences: 37866
Number of extensions: 2396146
Number of successful extensions: 21632
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 323
Number of HSP's successfully gapped in prelim test: 285
Number of HSP's that attempted gapping in prelim test: 15442
Number of HSP's gapped (non-prelim): 4125
length of query: 977
length of database: 18,247,518
effective HSP length: 112
effective length of query: 865
effective length of database: 14,006,526
effective search space: 12115644990
effective search space used: 12115644990
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.