Search of human proteins with 38683816

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
         (2352 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...  4657   0.0  
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...  3129   0.0  
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...  1518   0.0  
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                   1496   0.0  
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   917   0.0  
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   887   0.0  
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       308   4e-83
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        308   5e-83
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        308   5e-83
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        303   2e-81
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       296   2e-79
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        295   3e-79
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        295   3e-79
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        295   3e-79
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        295   3e-79
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   278   5e-74
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  259   2e-68
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   256   2e-67
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   246   1e-64
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   209   3e-53
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   206   3e-52
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   184   7e-46
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...   172   3e-42
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    167   1e-40
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   160   1e-38
gi|116534990 ankyrin-like protein 1 [Homo sapiens]                    160   1e-38
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...   157   9e-38
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...   157   9e-38
gi|67906195 ankyrin repeat and sterile alpha motif domain contai...   145   3e-34
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]            142   4e-33

>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score = 4657 bits (12080), Expect = 0.0
 Identities = 2352/2352 (100%), Positives = 2352/2352 (100%)

Query: 1    MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL 60
            MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
Sbjct: 1    MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL 60

Query: 61   LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE 120
            LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
Sbjct: 61   LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE 120

Query: 121  DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE 180
            DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
Sbjct: 121  DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE 180

Query: 181  AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE 240
            AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
Sbjct: 181  AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE 240

Query: 241  ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
            ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
Sbjct: 241  ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300

Query: 301  DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
            DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI
Sbjct: 301  DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360

Query: 361  EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
            EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL
Sbjct: 361  EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420

Query: 421  LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
            LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV
Sbjct: 421  LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480

Query: 481  ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
            ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL
Sbjct: 481  ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540

Query: 541  ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
            ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA
Sbjct: 541  ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600

Query: 601  LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
            LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT
Sbjct: 601  LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660

Query: 661  ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
            ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP
Sbjct: 661  ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720

Query: 721  NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS 780
            NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS
Sbjct: 721  NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS 780

Query: 781  GRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC 840
            GRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC
Sbjct: 781  GRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC 840

Query: 841  AGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD 900
            AGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD
Sbjct: 841  AGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD 900

Query: 901  TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 960
            TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS
Sbjct: 901  TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 960

Query: 961  RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1020
            RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL
Sbjct: 961  RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1020

Query: 1021 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1080
            LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG
Sbjct: 1021 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1080

Query: 1081 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM 1140
            HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM
Sbjct: 1081 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM 1140

Query: 1141 AAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAE 1200
            AAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAE
Sbjct: 1141 AAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAE 1200

Query: 1201 ANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFE 1260
            ANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFE
Sbjct: 1201 ANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFE 1260

Query: 1261 LQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKN 1320
            LQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKN
Sbjct: 1261 LQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKN 1320

Query: 1321 RKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNS 1380
            RKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNS
Sbjct: 1321 RKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNS 1380

Query: 1381 SRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLSTCT 1440
            SRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLSTCT
Sbjct: 1381 SRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLSTCT 1440

Query: 1441 KSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAI 1500
            KSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAI
Sbjct: 1441 KSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAI 1500

Query: 1501 REFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKS 1560
            REFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKS
Sbjct: 1501 REFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKS 1560

Query: 1561 SSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVN 1620
            SSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVN
Sbjct: 1561 SSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVN 1620

Query: 1621 NVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRP 1680
            NVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRP
Sbjct: 1621 NVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRP 1680

Query: 1681 LSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSS 1740
            LSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSS
Sbjct: 1681 LSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSS 1740

Query: 1741 PSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ 1800
            PSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ
Sbjct: 1741 PSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ 1800

Query: 1801 PGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQP 1860
            PGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQP
Sbjct: 1801 PGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQP 1860

Query: 1861 PGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTP 1920
            PGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTP
Sbjct: 1861 PGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTP 1920

Query: 1921 KMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSACQ 1980
            KMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSACQ
Sbjct: 1921 KMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSACQ 1980

Query: 1981 NSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYL 2040
            NSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYL
Sbjct: 1981 NSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYL 2040

Query: 2041 PNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQM 2100
            PNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQM
Sbjct: 2041 PNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQM 2100

Query: 2101 YGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPLGS 2160
            YGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPLGS
Sbjct: 2101 YGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPLGS 2160

Query: 2161 EKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDK 2220
            EKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDK
Sbjct: 2161 EKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDK 2220

Query: 2221 VDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGM 2280
            VDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGM
Sbjct: 2221 VDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGM 2280

Query: 2281 PFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGPWA 2340
            PFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGPWA
Sbjct: 2281 PFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGPWA 2340

Query: 2341 PHMNSVHMNQLG 2352
            PHMNSVHMNQLG
Sbjct: 2341 PHMNSVHMNQLG 2352


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
          Length = 2603

 Score = 3129 bits (8113), Expect = 0.0
 Identities = 1578/1589 (99%), Positives = 1579/1589 (99%)

Query: 764  PPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAID 823
            P   +  TL     AVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAID
Sbjct: 1015 PAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAID 1074

Query: 824  IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 883
            IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI
Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134

Query: 884  LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 943
            LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG
Sbjct: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194

Query: 944  YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1003
            YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT
Sbjct: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254

Query: 1004 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1063
            ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP
Sbjct: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314

Query: 1064 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1123
            PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ
Sbjct: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374

Query: 1124 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1183
            AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC
Sbjct: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1434

Query: 1184 HLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEE 1243
            HLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEE
Sbjct: 1435 HLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEE 1494

Query: 1244 QRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGS 1303
            QRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGS
Sbjct: 1495 QRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGS 1554

Query: 1304 HGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDS 1363
            HGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDS
Sbjct: 1555 HGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDS 1614

Query: 1364 DNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIK 1423
            DNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIK
Sbjct: 1615 DNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIK 1674

Query: 1424 LSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPS 1483
            LSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPS
Sbjct: 1675 LSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPS 1734

Query: 1484 TVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIK 1543
            TVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIK
Sbjct: 1735 TVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIK 1794

Query: 1544 DPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTV 1603
            DPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTV
Sbjct: 1795 DPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTV 1854

Query: 1604 PAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFG 1663
            PAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFG
Sbjct: 1855 PAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFG 1914

Query: 1664 GTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTS 1723
            GTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTS
Sbjct: 1915 GTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTS 1974

Query: 1724 SSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTA 1783
            SSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTA
Sbjct: 1975 SSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTA 2034

Query: 1784 KEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPN 1843
            KEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPN
Sbjct: 2035 KEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPN 2094

Query: 1844 SSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP 1903
            SSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP
Sbjct: 2095 SSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP 2154

Query: 1904 VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSV 1963
            VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSV
Sbjct: 2155 VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSV 2214

Query: 1964 PSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVV 2023
            PSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVV
Sbjct: 2215 PSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVV 2274

Query: 2024 SSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTP 2083
            SSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTP
Sbjct: 2275 SSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTP 2334

Query: 2084 SSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVS 2143
            SSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVS
Sbjct: 2335 SSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVS 2394

Query: 2144 SGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSV 2203
            SGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSV
Sbjct: 2395 SGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSV 2454

Query: 2204 GHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTF 2263
            GHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTF
Sbjct: 2455 GHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTF 2514

Query: 2264 HQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVS 2323
            HQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVS
Sbjct: 2515 HQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVS 2574

Query: 2324 SSTENNGPQTVWTGPWAPHMNSVHMNQLG 2352
            SSTENNGPQTVWTGPWAPHMNSVHMNQLG
Sbjct: 2575 SSTENNGPQTVWTGPWAPHMNSVHMNQLG 2603



 Score = 1539 bits (3984), Expect = 0.0
 Identities = 783/793 (98%), Positives = 787/793 (99%), Gaps = 1/793 (0%)

Query: 1   MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL 60
           MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
Sbjct: 1   MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL 60

Query: 61  LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE 120
           LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
Sbjct: 61  LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE 120

Query: 121 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE 180
           DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
Sbjct: 121 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE 180

Query: 181 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE 240
           AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
Sbjct: 181 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE 240

Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
           ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300

Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
           DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360

Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
           EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420

Query: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
           LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480

Query: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
           ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540

Query: 541 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
           ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA
Sbjct: 541 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600

Query: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
           LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660

Query: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
           ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP
Sbjct: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720

Query: 721 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS 780
           NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKA S
Sbjct: 721 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAAS 780

Query: 781 GRASAMSNTPTHS 793
            + S+ S+ P +S
Sbjct: 781 KQKSS-SHLPANS 792



 Score =  227 bits (578), Expect = 1e-58
 Identities = 145/365 (39%), Positives = 204/365 (55%), Gaps = 38/365 (10%)

Query: 823  DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
            D++AQ+ S  +TALT ACAGG+ ++V+ LLE GASIE  ++ G TPL+ A +AGHV V  
Sbjct: 326  DVNAQS-STGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVAR 384

Query: 883  ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942
            +LL+NGA I   S   K++ L+LAC  G  E+V  LL  GA++EH+    +T L  A   
Sbjct: 385  LLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD 444

Query: 943  GYVNIIKILLNAGAEINS-------------------------RTGSKL------GISPL 971
            G+V + ++LL++GA++N                            G+ L      G +PL
Sbjct: 445  GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL 504

Query: 972  MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1031
            M AA  GH   V LLL  G++INAQ E  + TALTLAC  G  EV   L+   A++E   
Sbjct: 505  MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC 564

Query: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1091
                TPLMEAA  G+ E+ + LL  GA+V+A    ++ DTALT A + GH    ++L+  
Sbjct: 565  S---TPLMEAAQEGHLELVKYLLAAGANVHA--TTATGDTALTYACENGHTDVADVLLQA 619

Query: 1092 GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD-AADNRKITPLMAAFRKGHVKV 1150
            GA ++  ++ G TPL  AA  GH+  VQ L+  GA+V+    N   T L  A   GH+ V
Sbjct: 620  GADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAV 679

Query: 1151 VRYLV 1155
            V  L+
Sbjct: 680  VELLL 684



 Score =  218 bits (555), Expect = 6e-56
 Identities = 202/688 (29%), Positives = 312/688 (45%), Gaps = 84/688 (12%)

Query: 634  LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693
            L +A   G V  V+ L+ +G +VN  T   + ++L LAC+ G+  + ++LLA  A+   R
Sbjct: 238  LAEACSEGDVNAVRKLLIEGRSVNEHTEEGE-SLLCLACSAGYYELAQVLLAMHANVEDR 296

Query: 694  -LKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQAL 752
             +K   T L+ AA GGH  +V  LL +                    D+N        AL
Sbjct: 297  GIKGDITPLMAAANGGHVKIVKLLLAH------------------KADVNAQSSTGNTAL 338

Query: 753  PMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISP 812
                     D     + +   I +   +G    M        A S    +          
Sbjct: 339  TYACAGGYVDVVKVLLESGASIEDHNENGHTPLME-------AGSAGHVEV--------- 382

Query: 813  SAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILA 872
             A L +     I+  +    ++ALTLAC  GH E+V+ LLE GA  EH+  +  T L+ A
Sbjct: 383  -ARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEA 441

Query: 873  ATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD 932
               GHV V  +LLD+GA +   ++ + ++PL+LA  GG  E+  LL+ RGA+ E  N   
Sbjct: 442  CMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500

Query: 933  YTPLSLAASGGYVNIIKILLNAGAEINSRTGS---------------------------- 964
            YTPL  AA  G+  ++ +LL  GA IN++T                              
Sbjct: 501  YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI 560

Query: 965  KLGIS-PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR 1023
            +LG S PLM AA  GH   VK LL  G++++A   T  +TALT AC  G T+V  +LL  
Sbjct: 561  ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATG-DTALTYACENGHTDVADVLLQA 619

Query: 1024 KANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYK 1083
             A++EH ++ G TPLM+AA  G+    + L+ KGA+VN     +   T L++A   GH  
Sbjct: 620  GADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDH-TVLSLACAGGHLA 678

Query: 1084 FCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAA---DNRKITPLM 1140
              ELL+  GA    R K G+T L  AA GGH  VV  L+    ++ +A   D  ++TP  
Sbjct: 679  VVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPS 738

Query: 1141 AAFRKGHVKVVRYL-----VKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKD 1195
                +     V+ L      +E ++ P++      I      +     HL   S    +D
Sbjct: 739  HDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHLPANS----QD 794

Query: 1196 RQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQ--RRKLEEIEA 1253
             Q    N++   ++EE    KL E  +R+  A ++  + +       +Q  + K+EE+  
Sbjct: 795  VQGYITNQSPESIVEEAQ-GKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELNK 853

Query: 1254 KNKENFELQAAQEKEKLKVEDEPEVLTE 1281
              +E  + +    +E  KVE E ++ T+
Sbjct: 854  TREEQIQKKQKILEELQKVERELQLKTQ 881



 Score =  218 bits (555), Expect = 6e-56
 Identities = 132/336 (39%), Positives = 193/336 (57%), Gaps = 10/336 (2%)

Query: 326  DVNAQS-STGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVAR 384
            D++AQ+ S  +TALT ACAGG+ ++V+ LLE GASIE  ++ G TPL+ A +AGHV V  
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 385  LLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD 444
            +LL+NGA I   S   K++ L+LAC  G  E+V  LL  GA++EH+    +T L  A   
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193

Query: 445  GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGASLE-EVNDEGY 501
            G+V + ++LL++GA++N    S    SPL LAA  GH     LL++ G+ +  ++     
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253

Query: 502  TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561
            T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG+ EV   L+  GAD+ 
Sbjct: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312

Query: 562  L-----GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616
                     T L  AA +GH +  + L+  GA++      G+T L  A   GH DV  +L
Sbjct: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372

Query: 617  LQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
            +QAGAD++       TPLM A R GHV  V++L+ +
Sbjct: 1373 VQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408



 Score =  202 bits (515), Expect = 2e-51
 Identities = 124/332 (37%), Positives = 192/332 (57%), Gaps = 5/332 (1%)

Query: 826  AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885
            A    + + +L  AC+ G    V+ LL  G S+    ++G + L LA +AG+  + ++LL
Sbjct: 228  ANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287

Query: 886  DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 945
               A++E +  +   TPL  A +GG  ++V+LLLA  A+   ++ +  T L+ A +GGYV
Sbjct: 288  AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYV 347

Query: 946  NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1005
            +++K+LL +GA I     ++ G +PLM A   GH    +LLL+ G+ IN      + +AL
Sbjct: 348  DVVKVLLESGASIEDH--NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESAL 405

Query: 1006 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1065
            TLAC++G  E+V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P  
Sbjct: 406  TLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP-- 463

Query: 1066 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1125
              S ++ LT+AA  GH +   LLI RGA ++  N +G TPL  AA  GH ++V LL+  G
Sbjct: 464  ADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523

Query: 1126 ADVDA-ADNRKITPLMAAFRKGHVKVVRYLVK 1156
            A+++A  +  + T L  A   G ++V  +L+K
Sbjct: 524  ANINAQTEETQETALTLACCGGFLEVADFLIK 555



 Score =  202 bits (515), Expect = 2e-51
 Identities = 124/332 (37%), Positives = 192/332 (57%), Gaps = 5/332 (1%)

Query: 228  ANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287
            A    + + +L  AC+ G    V+ LL  G S+    ++G + L LA +AG+  + ++LL
Sbjct: 1077 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 1136

Query: 288  AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYV 347
               A++E +  +   TPL  A +GG  ++V+LLLA  A+   ++ +  T L+ A +GGYV
Sbjct: 1137 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 1196

Query: 348  DVVKVLLESGASIEDH--NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESAL 405
            +++K+LL +GA I     ++ G +PLM A   GH    +LLL+ G+ IN      + +AL
Sbjct: 1197 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1256

Query: 406  TLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP-- 463
            TLAC++G  E+V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P  
Sbjct: 1257 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316

Query: 464  ADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523
              S ++ LT+AA  GH +   LLI RGA ++  N +G TPL  AA  GH ++V LL+  G
Sbjct: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376

Query: 524  ANINAQTEETQETALTLACCGGFLEVADFLIK 555
            A+++A  +  + T L  A   G ++V  +L+K
Sbjct: 1377 ADVDA-ADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score =  190 bits (482), Expect = 2e-47
 Identities = 132/334 (39%), Positives = 181/334 (54%), Gaps = 11/334 (3%)

Query: 360  IEDHNENGH-TPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVR 418
            I+   E+ H T L  A + GH E+ + LLE GA I  H ++   + L LA   GH+ +V 
Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIE-HRDKKGFTPLILAATAGHVGVVE 1133

Query: 419  FLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 477
             LL+ GAD E +++    T L  AC  G  EV  LLL  GA       S  +PL+LAA G
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193

Query: 478  GHVELAALLIERGASLEEVNDE--GYTPLMEAAREGHEEMVALLLGQGANINAQTEETQE 535
            G+V +  +L+  GA +        G +PLM AA  GH   V LLL  G++INAQ E  + 
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253

Query: 536  TALTLACCGGFLEVADFLIKAGADIELGCST---PLMEAAQEGHLELVKYLLAAGANVHA 592
            TALTLAC  G  EV   L+   A++E    T   PLMEAA  G+ E+ + LL  GA+V+A
Sbjct: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1313

Query: 593  --TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650
                ++ DTALT A + GH    ++L+  GA ++  ++ G TPL  AA  GH+  VQ L+
Sbjct: 1314 PPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373

Query: 651  SKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
              GA+V+    N   T L  A   GH+ VV  L+
Sbjct: 1374 QAGADVD-AADNRKITPLMAAFRKGHVKVVRYLV 1406



 Score =  176 bits (446), Expect = 2e-43
 Identities = 122/341 (35%), Positives = 183/341 (53%), Gaps = 16/341 (4%)

Query: 655  NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
            +++  T +N  T L+LACAGGH  +V+ LL  GA   HR K G T LI AA  GH  VV 
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 715  YLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPI 774
             LLD  N        + T+ TP    L+ A     Q +  ++  +  +K   NV+   P+
Sbjct: 1134 ILLD--NGADIEAQSERTKDTP----LSLACSGGRQEVVELLLARGANKEHRNVSDYTPL 1187

Query: 775  RNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPII-------SPSAMLPIYPAIDIDAQ 827
               A  G  + +          +         SP++       + +  L +    DI+AQ
Sbjct: 1188 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 1247

Query: 828  TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 887
             E+N +TALTLAC  G  E+V  LL+R A++EHR K G TPL+ AA+ G+  V  +LLD 
Sbjct: 1248 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1307

Query: 888  GADIEAQS-ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVN 946
            GAD+ A     ++DT L++A   G  +  ELL+ RGA+ + RN    TPL LAA+GG+++
Sbjct: 1308 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD 1367

Query: 947  IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLL 987
            ++++L+ AGA++++    K  I+PLM A   GH   V+ L+
Sbjct: 1368 VVQLLVQAGADVDAADNRK--ITPLMAAFRKGHVKVVRYLV 1406



 Score =  166 bits (421), Expect = 2e-40
 Identities = 125/343 (36%), Positives = 173/343 (50%), Gaps = 45/343 (13%)

Query: 426  DQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484
            D + +T+  H TAL  AC  GH E+ + LL+ GA +        +PL LAA  GHV +  
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 485  LLIERGASLEEVNDEGY-TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACC 543
            +L++ GA +E  ++    TPL  A   G +E+V LLL +GAN       +  T L+LA  
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGAN-KEHRNVSDYTPLSLAAS 1192

Query: 544  GGFLEVADFLIKAGADI------ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
            GG++ +   L+ AGA+I      +LG S PLM AA  GH   VK LL  G++++A   T 
Sbjct: 1193 GGYVNIIKILLNAGAEINSRTGSKLGIS-PLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1251

Query: 598  -DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANV 656
             +TALT AC  G T+V  +LL   A++EH ++ G TPLM+AA  G+    + L+ KGA+V
Sbjct: 1252 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311

Query: 657  N-------RTTA---------------------------NNDHTVLSLACAGGHLAVVEL 682
            N       R TA                              +T L LA  GGHL VV+L
Sbjct: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371

Query: 683  LLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLS 725
            L+  GAD         T L+ A + GH  VV YL+   N   S
Sbjct: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS 1414



 Score =  157 bits (398), Expect = 9e-38
 Identities = 105/300 (35%), Positives = 153/300 (51%), Gaps = 36/300 (12%)

Query: 889  ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 948
            A+  A + ++ +  L+ ACS G    V  LL  G +         + L LA S GY  + 
Sbjct: 224  AESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELA 283

Query: 949  KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1008
            ++LL   A +  R G K  I+PLM AA  GH   VKLLL   +D+NAQ  T  NTALT A
Sbjct: 284  QVLLAMHANVEDR-GIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTG-NTALTYA 341

Query: 1009 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1068
            C  G  +VV +LL+  A++E   + G TPLMEA S G+ EV R+LL+ GA +N       
Sbjct: 342  CAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS-NEF 400

Query: 1069 RDTALTIAADKGHYKF---------------------------------CELLIGRGAHI 1095
            +++ALT+A  KGH +                                    LL+  GA +
Sbjct: 401  KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 460

Query: 1096 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155
            ++      +PL LAA GGH+++  LL++ GA ++  ++   TPLM A R+GH ++V  L+
Sbjct: 461  NMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520



 Score =  156 bits (395), Expect = 2e-37
 Identities = 100/268 (37%), Positives = 147/268 (54%), Gaps = 3/268 (1%)

Query: 224  AESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELA 283
            A+  A + ++ +  L+ ACS G    V  LL  G +         + L LA S GY  + 
Sbjct: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199

Query: 284  QVLLAMHANVEDR-GIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTG-NTALTYA 341
            ++LL   A +  R G K  I+PLM AA  GH   VKLLL   +D+NAQ  T  NTALT A
Sbjct: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1259

Query: 342  CAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS-NEF 400
            C  G  +VV +LL+  A++E   + G TPLMEA S G+ EV R+LL+ GA +N       
Sbjct: 1260 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1319

Query: 401  KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 460
            +++ALT+A  KGH +    L+  GA  + +  + +T L  A   GH++V +LL+ +GA V
Sbjct: 1320 RDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADV 1379

Query: 461  NMPADSFESPLTLAACGGHVELAALLIE 488
            +   +   +PL  A   GHV++   L++
Sbjct: 1380 DAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score =  150 bits (379), Expect = 1e-35
 Identities = 130/402 (32%), Positives = 187/402 (46%), Gaps = 76/402 (18%)

Query: 525  NINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLL 584
            +I+AQTE   +TALTLAC GG                              H ELV+ LL
Sbjct: 1074 DIDAQTESNHDTALTLACAGG------------------------------HEELVQTLL 1103

Query: 585  AAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR-TPLMKAARAGHV 643
              GA++      G T L  A   GH  V ++LL  GAD+E +SE  + TPL  A   G  
Sbjct: 1104 ERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQ 1163

Query: 644  CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRL--KDGSTML 701
              V+ L+++GAN       +D+T LSLA +GG++ ++++LL  GA+   R   K G + L
Sbjct: 1164 EVVELLLARGANKEHRNV-SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPL 1222

Query: 702  IEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEP 761
            + AA  GHT+ V  LLD  +++ +              + NR                  
Sbjct: 1223 MLAAMNGHTAAVKLLLDMGSDINA------------QIETNR------------------ 1252

Query: 762  DKPPANVATTLPI---RNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPI 818
                 N A TL     R + VS      +N   H     ++ P     S   +    + +
Sbjct: 1253 -----NTALTLACFQGRTEVVSLLLDRKANV-EHRAKTGLT-PLMEAASGGYAEVGRVLL 1305

Query: 819  YPAIDIDA-QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH 877
                D++A    S+ DTALT+A   GH +  + L+ RGA I+ R+KKG TPL LAA  GH
Sbjct: 1306 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGH 1365

Query: 878  VGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL 919
            + VV++L+  GAD++A   R K TPL  A   G  +VV  L+
Sbjct: 1366 LDVVQLLVQAGADVDAADNR-KITPLMAAFRKGHVKVVRYLV 1406



 Score =  134 bits (338), Expect = 8e-31
 Identities = 90/234 (38%), Positives = 124/234 (52%), Gaps = 7/234 (2%)

Query: 502  TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561
            T L  A   GHEE+V  LL +GA+I  + ++   T L LA   G + V + L+  GADIE
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHR-DKKGFTPLILAATAGHVGVVEILLDNGADIE 1143

Query: 562  LGCS----TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL 617
                    TPL  A   G  E+V+ LLA GAN      +  T L+ A   G+ ++  +LL
Sbjct: 1144 AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203

Query: 618  QAGADLEHE--SEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGG 675
             AGA++     S+ G +PLM AA  GH   V+ L+  G+++N     N +T L+LAC  G
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263

Query: 676  HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPP 729
               VV LLL   A+  HR K G T L+EAA GG+  V   LLD   ++ + P P
Sbjct: 1264 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1317



 Score = 91.7 bits (226), Expect = 8e-18
 Identities = 59/175 (33%), Positives = 91/175 (52%), Gaps = 1/175 (0%)

Query: 982  AVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEA 1041
            A   L  M ++  A    + N +L  AC +G    V  LL    +V    + G + L  A
Sbjct: 215  AAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLA 274

Query: 1042 ASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKK 1101
             S GY E+ +VLL   A+V    +     T L  AA+ GH K  +LL+   A ++ ++  
Sbjct: 275  CSAGYYELAQVLLAMHANVEDRGIKGD-ITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333

Query: 1102 GNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
            GNT L  A  GG++DVV++L+++GA ++  +    TPLM A   GHV+V R L++
Sbjct: 334  GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLE 388



 Score = 91.7 bits (226), Expect = 8e-18
 Identities = 59/175 (33%), Positives = 91/175 (52%), Gaps = 1/175 (0%)

Query: 215  AAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLA 274
            A   L  M ++  A    + N +L  AC +G    V  LL    +V    + G + L  A
Sbjct: 1233 AVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEA 1292

Query: 275  CSAGYYELAQVLLAMHANVEDRGIKGD-ITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
             S GY E+ +VLL   A+V    +     T L  AA+ GH K  +LL+   A ++ ++  
Sbjct: 1293 ASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKK 1352

Query: 334  GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLE 388
            GNT L  A  GG++DVV++L+++GA ++  +    TPLM A   GHV+V R L++
Sbjct: 1353 GNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 2542

 Score = 1518 bits (3930), Expect = 0.0
 Identities = 869/1638 (53%), Positives = 1080/1638 (65%), Gaps = 97/1638 (5%)

Query: 745  PRVPVQALPMVVPPQEPD-----KPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASIS 799
            P++ +      +  QEPD      P   +  TL     AVS R    SN+ + +      
Sbjct: 964  PQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTP 1023

Query: 800  QPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIE 859
            +  + T S + S S M P+YP++DIDA TESNHDTALTLACAGGHEELV  L+ R A IE
Sbjct: 1024 ESCSQTTSNVASQS-MPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIE 1082

Query: 860  HRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL 919
            HRDKKGFTPLILAATAGHVGVVEILLD G DIEAQSERTKDTPLSLACSGGRQEVV+LLL
Sbjct: 1083 HRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLL 1142

Query: 920  ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 979
            ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH
Sbjct: 1143 ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1202

Query: 980  TAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLM 1039
              AVKLLLDMGSDINAQIETNRNTALTLACFQGR EVVSLLLDRKANVEHRAKTGLTPLM
Sbjct: 1203 VPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262

Query: 1040 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRN 1099
            EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI RGAHIDVRN
Sbjct: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322

Query: 1100 KKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1159
            KKGNTPLWLA+NGGH DVVQLLVQAGADVDAADNRKITPLM+AFRKGHVKVV+YLVKEVN
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 1382

Query: 1160 QFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLRE 1219
            QFPSD ECMRYIATITDKE+LKKCH C+E+IV+AKD+QAAEANKNASILL+ELDLEK RE
Sbjct: 1383 QFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSRE 1442

Query: 1220 ESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEA-KNKENFELQAAQEKEKLKVEDEPEV 1278
            ESR+ ALAAKREKRKEKR+KKKEEQ+RK EE E  K KEN EL   +++E+   + E EV
Sbjct: 1443 ESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQEV 1502

Query: 1279 LTEPPSATTTTTIGISATWTTLAGSHG-KRNNTITTTSSKRKNRKNKI--TPENVQIIFD 1335
              EPPSATTTTTIGISAT  T     G KR N +TT S+ RKN+KNK   TP    +I  
Sbjct: 1503 PIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILP 1562

Query: 1336 D---PLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVV 1392
            +    L    +   K+NGE +      + DSDN+  + C+ ESS+   S++ +       
Sbjct: 1563 EQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELN------F 1616

Query: 1393 TTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNG 1452
               V+S K PS+L+   +E+  + + K   +L     E T NSLST  K+   PLSSPN 
Sbjct: 1617 VMDVNSSKYPSLLLHSQEEKTSTATSKTQTRLE---GEVTPNSLSTSYKTVSLPLSSPNI 1673

Query: 1453 KLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDK 1512
            KL + SPKRGQKREEGWKEVVRRSKK+SVP++V+SR++GRGGCNI AI++ TGAHID+DK
Sbjct: 1674 KLNLTSPKRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDK 1733

Query: 1513 QKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLK----SSSANSKIG 1568
            QKDK G+R+ITIRGGTESTR A QLINALI+DP KE+++LIPKN ++    + S ++   
Sbjct: 1734 QKDKNGERMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFS 1793

Query: 1569 SSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPV 1628
            S   TT A++ +   +   T+    TSQ  T  T         +K  KN   NVR  FPV
Sbjct: 1794 SGVGTTAASSKNAFPLGAPTLV---TSQATTLSTF-----QPANKLNKNVPTNVRSSFPV 1845

Query: 1629 SLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATN 1688
            SLPLAYP P F  ALLAAQT QQIR PRLPM  FGGTF P+ +TWGPFPVRP++P    +
Sbjct: 1846 SLPLAYPHPHF--ALLAAQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNS 1903

Query: 1689 SPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLF 1748
            SPK +   R  NQN +     SAG  T+S   T SS  +         + +  SVR+QLF
Sbjct: 1904 SPKHNNTSRLPNQNGTVLPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLF 1963

Query: 1749 VTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNS 1808
              V KTS    T +++  S  ++ P+ ++ P+ + +      +P++  P +       + 
Sbjct: 1964 ACVPKTS-PPATVISSVTSTCSSLPSVSSAPITSGQ------APTTFLPASTSQAQLSSQ 2016

Query: 1809 PLDCGSASP---NKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAH-SNQQQPPGSV 1864
             ++  SA P    KV++  +  A       T N+   ++S++ G+   H S+   P  S 
Sbjct: 2017 KMESFSAVPPTKEKVSTQDQPMANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSN 2076

Query: 1865 SQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP--------VTYPMPQTPMGCP 1916
            +QE   P   S + P  +     P A++S P  +  T+P         T  +PQ  +  P
Sbjct: 2077 TQEEAQPSSVSDLSPMSM-----PFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAP 2131

Query: 1917 QPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHI--KRPHSVPSSVQLPSTLS 1974
            + + +M+       P G+      +A++     ++   N +    P   P++VQL S ++
Sbjct: 2132 RVSHRMQ-------PRGSFYSMVPNATIHQDPQSIFVTNPVTLTPPQGPPAAVQLSSAVN 2184

Query: 1975 TQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLS 2034
              +  Q  ++PANK + P F     F  FS+LF++S   A+  WG   +SS+   ++  +
Sbjct: 2185 IMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSSQVPANQGWGDGPLSSRVATDASFT 2244

Query: 2035 GKSSYLPNSDPLH----QSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGN 2090
             +S++L NS   H      D SKAPGFRPP QR + SP G+ ++D    S + SS  L +
Sbjct: 2245 VQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVSTSPVGLPSIDPSGSSPSSSSAPLAS 2304

Query: 2091 FASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPS 2150
            F S I G +++  G    G P   +FNRQHFSP     P +SASN S++           
Sbjct: 2305 F-SGIPGTRVFLQGPAPVGTP---SFNRQHFSP----HPWTSASNSSTS----------- 2345

Query: 2151 PAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWS 2210
             AP +  LG  K  + SQDRK+P PIGTER ARIRQ G+ A +  G++    VGHSGIWS
Sbjct: 2346 -APPT--LGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGIWS 2402

Query: 2211 FEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAG 2270
            F     ++    W    MGN  +H+ +SDP  FSQHQ MERD +G+V PS  FHQ + +G
Sbjct: 2403 FGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMASG 2462

Query: 2271 YMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNG 2330
            ++DF K  G+P S+YG  +IP    + D  GGP+FNG H  DP+WN +IK++ +STE   
Sbjct: 2463 FVDFSK--GLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD 2520

Query: 2331 PQTVWTGPWAPHMNSVHM 2348
             Q +W G WAPH+ ++H+
Sbjct: 2521 AQQIWPGTWAPHIGNMHL 2538



 Score = 1158 bits (2995), Expect = 0.0
 Identities = 591/701 (84%), Positives = 633/701 (90%), Gaps = 23/701 (3%)

Query: 78  RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122
           RT R    +  +S   +SGGGG G G GGG               GGG  ++ S+E+E  
Sbjct: 42  RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99

Query: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182
                 VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153

Query: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
           GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 154 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 213

Query: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302
           S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 214 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273

Query: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
           TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL  GA+IED
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333

Query: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
           HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
           AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453

Query: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
           AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513

Query: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
           CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 514 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573

Query: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662
           YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH+CTVQFLISKGANVNR TAN
Sbjct: 574 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633

Query: 663 NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722
           NDHTV+SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT+VV YLLDYPNN
Sbjct: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693

Query: 723 LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDK 763
           +LS P  DV+QL PPS D ++ PRVP   L MVVPPQEPD+
Sbjct: 694 VLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDR 734



 Score =  223 bits (568), Expect = 2e-57
 Identities = 141/365 (38%), Positives = 205/365 (56%), Gaps = 38/365 (10%)

Query: 823  DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
            D+++Q+ + + TALT ACAGG  ++V+ LL  GA+IE  ++ G TPL+ AA+AGHV V  
Sbjct: 297  DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355

Query: 883  ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942
            +LLD+GA I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A   
Sbjct: 356  VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415

Query: 943  GYVNIIKILLNAGAEINS-------------------------RTGSKL------GISPL 971
            G+V + ++LL++GA++N                            G+ L      G +PL
Sbjct: 416  GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 475

Query: 972  MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1031
            M AA  GH   V LLL  G++INAQ E  + TALTLAC  G +EV   L+   A++E   
Sbjct: 476  MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC 535

Query: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1091
                TPLMEA+  G+ E+ + LL  GA+V+A    ++ DTALT A + GH    ++L+  
Sbjct: 536  S---TPLMEASQEGHLELVKYLLASGANVHA--TTATGDTALTYACENGHTDVADVLLQA 590

Query: 1092 GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD-AADNRKITPLMAAFRKGHVKV 1150
            GA ++  ++ G TPL  AA  GHL  VQ L+  GA+V+ A  N   T +  A   GH+ V
Sbjct: 591  GADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAV 650

Query: 1151 VRYLV 1155
            V  L+
Sbjct: 651  VELLL 655



 Score =  207 bits (527), Expect = 1e-52
 Identities = 155/484 (32%), Positives = 241/484 (49%), Gaps = 55/484 (11%)

Query: 118  EEEDDDDEEEEVSEVESF-ILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLE 176
            ++ D DDE++     E    +    L +P    +S L  +GT +  +L+ V    Q   +
Sbjct: 905  KDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGT-NSLELQKVSGNQQIVGQ 963

Query: 177  ALLEAAGIGK---LSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQS 233
              +   G  +   +   DG   A P        +++  LD+  AA++      + ++ Q+
Sbjct: 964  PQIAITGHDQGLLVQEPDGLMVATP------AQTLTDTLDDLIAAVSTRVPTGSNSSSQT 1017

Query: 234  DNRSLAEACSEGDVNAVRKLL---IEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 289
                  E+CS+   N   + +        ++ HTE   ++ L LAC+ G+ EL  VL+A 
Sbjct: 1018 TECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIAR 1077

Query: 290  HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSS-TGNTALTYACAGG--- 345
             A +E R  KG  TPL+ AA  GHV +V++LL    D+ AQS  T +T L+ AC+GG   
Sbjct: 1078 DAKIEHRDKKG-FTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 1136

Query: 346  ------------------------------YVDVVKVLLESGASIEDH--NENGHTPLME 373
                                          YV+++K+LL +GA I     ++ G +PLM 
Sbjct: 1137 VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML 1196

Query: 374  AGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDE 433
            A   GHV   +LLL+ G+ IN      + +ALTLAC++G  E+V  LL+  A+ EH+   
Sbjct: 1197 AAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKT 1256

Query: 434  MHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLTLAACGGHVELAALLIERGA 491
              T LMEA   G+ EV R+LLD GA VN P    S ++ LT+AA  GH +   LLI RGA
Sbjct: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316

Query: 492  SLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVAD 551
             ++  N +G TPL  A+  GH ++V LL+  GA+++A  +  + T L  A   G ++V  
Sbjct: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA-ADNRKITPLMSAFRKGHVKVVQ 1375

Query: 552  FLIK 555
            +L+K
Sbjct: 1376 YLVK 1379



 Score =  207 bits (527), Expect = 1e-52
 Identities = 128/336 (38%), Positives = 188/336 (55%), Gaps = 10/336 (2%)

Query: 326  DVNAQS-STGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVAR 384
            D++A + S  +TALT ACAGG+ ++V VL+   A IE  ++ G TPL+ A +AGHV V  
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 385  LLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD 444
            +LL+ G  I   S   K++ L+LAC  G  E+V  LL  GA++EH+    +T L  A   
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 445  GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGASLE-EVNDEGY 501
            G+V + ++LL++GA++N    S    SPL LAA  GHV    LL++ G+ +  ++     
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 502  TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561
            T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG+ EV   L+  GAD+ 
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284

Query: 562  L-----GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616
                     T L  AA +GH +  + L+  GA++      G+T L  A   GH DV  +L
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344

Query: 617  LQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
            +QAGAD++       TPLM A R GHV  VQ+L+ +
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  207 bits (526), Expect = 1e-52
 Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)

Query: 835  ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 894
            +L  AC+ G    V+ LL+ G S+    ++G + L LA +AG+  + ++LL   A++E +
Sbjct: 208  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 895  SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 954
              +   TPL  A SGG  ++V+LLL   A+   ++ +  T L+ A +GG+V+I+K+LLN 
Sbjct: 268  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 955  GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1014
            GA I     ++ G +PLM AA  GH    ++LLD G+ IN      + +ALTLAC++G  
Sbjct: 328  GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385

Query: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1074
            ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++ LT
Sbjct: 386  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 443

Query: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1134
            +AA  GH +   LLI RGA+++  N +G TPL  AA  GH ++V LL+  GA+++A    
Sbjct: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 1135 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1155
                                             TPLM A ++GH+++V+YL+
Sbjct: 504  TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555



 Score =  189 bits (481), Expect = 2e-47
 Identities = 192/692 (27%), Positives = 301/692 (43%), Gaps = 97/692 (14%)

Query: 654  ANVNRTTANNDHTV-------LSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 706
            A + R  A N H         L+ AC+ G +  V  LL  G       ++G ++L  A  
Sbjct: 188  AALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACS 247

Query: 707  GGHTSVVCYLLDYPNNLLS-APPPDVTQLTPPSH----DLNRAPRVPVQALPMVVPPQEP 761
             G+  +   LL    N+       D+T L   S     D+       V+ L +       
Sbjct: 248  AGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDI-------VKLLLLHDADVNS 300

Query: 762  DKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPA 821
                 N A T       V      ++        A+I        +P++  ++   +  A
Sbjct: 301  QSATGNTALTYACAGGFVDIVKVLLNE------GANIEDHNENGHTPLMEAASAGHVEVA 354

Query: 822  ---IDIDA--QTESNH--DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAAT 874
               +D  A   T SN   ++ALTLAC  GH ++V+ LLE GA  EH+  +  T L+ A  
Sbjct: 355  RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414

Query: 875  AGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYT 934
             GHV V  +LLD+GA +   ++ + ++PL+LA  GG  E+  LL+ RGAN E  N   YT
Sbjct: 415  DGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473

Query: 935  PLSLAASGGYVNIIKILLNAGAEINSRTGS----------------------------KL 966
            PL  AA  G+  ++ +LL  GA IN++T                              +L
Sbjct: 474  PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 533

Query: 967  GIS-PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKA 1025
            G S PLM A+  GH   VK LL  G++++A   T  +TALT AC  G T+V  +LL   A
Sbjct: 534  GCSTPLMEASQEGHLELVKYLLASGANVHATTATG-DTALTYACENGHTDVADVLLQAGA 592

Query: 1026 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1085
            ++EH ++ G TPLM+AA  G+    + L+ KGA+VN     +   T +++A   GH    
Sbjct: 593  DLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVV 651

Query: 1086 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFR- 1144
            ELL+  GA    R K G+T L  AA GGH +VV  L+    +V +     ++ L    + 
Sbjct: 652  ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQD 711

Query: 1145 -------KGHVKVVRYLVKEVNQFPSD------------SECMRYIATITDKEMLKKCH- 1184
                     H   +    +E ++   +            S+       + D+++L   H 
Sbjct: 712  QSQVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHP 771

Query: 1185 -LCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEE 1243
               +E IV+  + +  E  +  S       +EK + +S  L       K K +  KK  E
Sbjct: 772  YQPLECIVEETEGKLNELGQRISA------IEKAQLKSLELIQGEPLNKDKIEELKKNRE 825

Query: 1244 QRRKLEEIEAKNKENFELQAAQEKEKLKVEDE 1275
                 E+++ K K   ELQ  + + ++K + +
Sbjct: 826  -----EQVQKKKKILKELQKVERQLQMKTQQQ 852



 Score =  183 bits (465), Expect = 2e-45
 Identities = 128/334 (38%), Positives = 179/334 (53%), Gaps = 11/334 (3%)

Query: 360  IEDHNENGH-TPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVR 418
            I+ H E+ H T L  A + GH E+  +L+   A I  H ++   + L LA   GH+ +V 
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIE-HRDKKGFTPLILAATAGHVGVVE 1105

Query: 419  FLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 477
             LL+ G D E +++    T L  AC  G  EV  LLL  GA       S  +PL+LAA G
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 478  GHVELAALLIERGASLEEVNDE--GYTPLMEAAREGHEEMVALLLGQGANINAQTEETQE 535
            G+V +  +L+  GA +        G +PLM AA  GH   V LLL  G++INAQ E  + 
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 536  TALTLACCGGFLEVADFLIKAGADIELGCST---PLMEAAQEGHLELVKYLLAAGANVHA 592
            TALTLAC  G  EV   L+   A++E    T   PLMEAA  G+ E+ + LL  GA+V+A
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1285

Query: 593  --TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650
                ++ DTALT A + GH    ++L+  GA ++  ++ G TPL  A+  GH   VQ L+
Sbjct: 1286 PPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1345

Query: 651  SKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
              GA+V+    N   T L  A   GH+ VV+ L+
Sbjct: 1346 QAGADVD-AADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score =  175 bits (443), Expect = 5e-43
 Identities = 129/360 (35%), Positives = 192/360 (53%), Gaps = 20/360 (5%)

Query: 655  NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
            +++  T +N  T L+LACAGGH  +V +L+A  A   HR K G T LI AA  GH  VV 
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 715  YLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPI 774
             LLD   ++      + T+ TP    L+ A     Q +  ++  +  +K   NV+   P+
Sbjct: 1106 ILLDKGGDI--EAQSERTKDTP----LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1159

Query: 775  RNKAVSG---------RASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDID 825
               A  G          A A  N+ T S    IS       +  + P+  L +    DI+
Sbjct: 1160 SLAASGGYVNIIKILLNAGAEINSRTGS-KLGISPLMLAAMNGHV-PAVKLLLDMGSDIN 1217

Query: 826  AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885
            AQ E+N +TALTLAC  G  E+V  LL+R A++EHR K G TPL+ AA+ G+  V  +LL
Sbjct: 1218 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1277

Query: 886  DNGADIEAQS-ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGY 944
            D GAD+ A     ++DT L++A   G  +  ELL+ RGA+ + RN    TPL LA++GG+
Sbjct: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337

Query: 945  VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTA 1004
             +++++L+ AGA++++    K  I+PLM A   GH   V+ L+   +   + IE  R  A
Sbjct: 1338 FDVVQLLVQAGADVDAADNRK--ITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIA 1395



 Score =  154 bits (388), Expect = 1e-36
 Identities = 114/333 (34%), Positives = 161/333 (48%), Gaps = 11/333 (3%)

Query: 593  TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
            T +  DTALT AC  GH ++  VL+   A +EH  + G TPL+ AA AGHV  V+ L+ K
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110

Query: 653  GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
            G ++   +     T LSLAC+GG   VV+LLLA GA+  HR     T L  AA GG+ ++
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170

Query: 713  VCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTL 772
            +  LL+    + S     +         +N         L M        +   N A TL
Sbjct: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230

Query: 773  PIRNKAVSGRASAMS-----NTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDA- 826
                    GRA  +S            A +   P     S   +    + +    D++A 
Sbjct: 1231 ----ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286

Query: 827  QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886
               S+ DTALT+A   GH +  + L+ RGA I+ R+KKG TPL LA+  GH  VV++L+ 
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346

Query: 887  NGADIEAQSERTKDTPLSLACSGGRQEVVELLL 919
             GAD++A   R K TPL  A   G  +VV+ L+
Sbjct: 1347 AGADVDAADNR-KITPLMSAFRKGHVKVVQYLV 1378



 Score =  131 bits (330), Expect = 7e-30
 Identities = 88/234 (37%), Positives = 123/234 (52%), Gaps = 7/234 (2%)

Query: 502  TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561
            T L  A   GHEE+V++L+ + A I  + ++   T L LA   G + V + L+  G DIE
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHR-DKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 562  LGCS----TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL 617
                    TPL  A   G  E+V  LLA GAN      +  T L+ A   G+ ++  +LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175

Query: 618  QAGADLEHE--SEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGG 675
             AGA++     S+ G +PLM AA  GHV  V+ L+  G+++N     N +T L+LAC  G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235

Query: 676  HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPP 729
               VV LLL   A+  HR K G T L+EAA GG+  V   LLD   ++ + P P
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1289



 Score = 72.0 bits (175), Expect = 6e-12
 Identities = 53/165 (32%), Positives = 82/165 (49%), Gaps = 6/165 (3%)

Query: 995  AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVL 1053
            A  E  R    +++C     E  + L   KA   H A +     L EA S G     R L
Sbjct: 167  ADPEVLRRLTSSVSC--ALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKL 224

Query: 1054 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN-TPLWLAANG 1112
            LD+G  VN        ++ L +A   G+Y+  ++L+   A+++ R  KG+ TPL  A++G
Sbjct: 225  LDEGRSVNEHT--EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG 282

Query: 1113 GHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
            G+LD+V+LL+   ADV++      T L  A   G V +V+ L+ E
Sbjct: 283  GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 31/146 (21%), Positives = 55/146 (37%), Gaps = 18/146 (12%)

Query: 71   HHKAKRNRTCRPPSSSE----------SSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE 120
            + K K+N+T   P ++           +   +D +   G   GGG GG   S N    + 
Sbjct: 1542 NRKNKKNKTKETPPTAHLILPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDC 1601

Query: 121  DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE 180
            + +      S+  +F++D +  + P L   S+   + TA          +TQ RLE  + 
Sbjct: 1602 NSESSSGGKSQELNFVMDVNSSKYPSLLLHSQEEKTSTATS--------KTQTRLEGEVT 1653

Query: 181  AAGIGKLSTADGKAFADPEVLRRLTS 206
               +           + P +   LTS
Sbjct: 1654 PNSLSTSYKTVSLPLSSPNIKLNLTS 1679


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score = 1496 bits (3872), Expect = 0.0
 Identities = 864/1631 (52%), Positives = 1070/1631 (65%), Gaps = 97/1631 (5%)

Query: 745  PRVPVQALPMVVPPQEPD-----KPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASIS 799
            P++ +      +  QEPD      P   +  TL     AVS R    SN+ + +      
Sbjct: 964  PQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTP 1023

Query: 800  QPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIE 859
            +  + T S + S S M P+YP++DIDA TESNHDTALTLACAGGHEELV  L+ R A IE
Sbjct: 1024 ESCSQTTSNVASQS-MPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIE 1082

Query: 860  HRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL 919
            HRDKKGFTPLILAATAGHVGVVEILLD G DIEAQSERTKDTPLSLACSGGRQEVV+LLL
Sbjct: 1083 HRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLL 1142

Query: 920  ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 979
            ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH
Sbjct: 1143 ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1202

Query: 980  TAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLM 1039
              AVKLLLDMGSDINAQIETNRNTALTLACFQGR EVVSLLLDRKANVEHRAKTGLTPLM
Sbjct: 1203 VPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262

Query: 1040 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRN 1099
            EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI RGAHIDVRN
Sbjct: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322

Query: 1100 KKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1159
            KKGNTPLWLA+NGGH DVVQLLVQAGADVDAADNRKITPLM+AFRKGHVKVV+YLVKEVN
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 1382

Query: 1160 QFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLRE 1219
            QFPSD ECMRYIATITDKE+LKKCH C+E+IV+AKD+QAAEANKNASILL+ELDLEK RE
Sbjct: 1383 QFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSRE 1442

Query: 1220 ESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEA-KNKENFELQAAQEKEKLKVEDEPEV 1278
            ESR+ ALAAKREKRKEKR+KKKEEQ+RK EE E  K KEN EL   +++E+   + E EV
Sbjct: 1443 ESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQEV 1502

Query: 1279 LTEPPSATTTTTIGISATWTTLAGSHG-KRNNTITTTSSKRKNRKNKI--TPENVQIIFD 1335
              EPPSATTTTTIGISAT  T     G KR N +TT S+ RKN+KNK   TP    +I  
Sbjct: 1503 PIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILP 1562

Query: 1336 D---PLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVV 1392
            +    L    +   K+NGE +      + DSDN+  + C+ ESS+   S++ +       
Sbjct: 1563 EQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELN------F 1616

Query: 1393 TTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNG 1452
               V+S K PS+L+   +E+  + + K   +L     E T NSLST  K+   PLSSPN 
Sbjct: 1617 VMDVNSSKYPSLLLHSQEEKTSTATSKTQTRLE---GEVTPNSLSTSYKTVSLPLSSPNI 1673

Query: 1453 KLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDK 1512
            KL + SPKRGQKREEGWKEVVRRSKK+SVP++V+SR++GRGGCNI AI++ TGAHID+DK
Sbjct: 1674 KLNLTSPKRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDK 1733

Query: 1513 QKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLK----SSSANSKIG 1568
            QKDK G+R+ITIRGGTESTR A QLINALI+DP KE+++LIPKN ++    + S ++   
Sbjct: 1734 QKDKNGERMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFS 1793

Query: 1569 SSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPV 1628
            S   TT A++ +   +   T+    TSQ  T  T         +K  KN   NVR  FPV
Sbjct: 1794 SGVGTTAASSKNAFPLGAPTLV---TSQATTLSTF-----QPANKLNKNVPTNVRSSFPV 1845

Query: 1629 SLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATN 1688
            SLPLAYP P F  ALLAAQT QQIR PRLPM  FGGTF P+ +TWGPFPVRP++P    +
Sbjct: 1846 SLPLAYPHPHF--ALLAAQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNS 1903

Query: 1689 SPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLF 1748
            SPK +   R  NQN +     SAG  T+S   T SS  +         + +  SVR+QLF
Sbjct: 1904 SPKHNNTSRLPNQNGTVLPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLF 1963

Query: 1749 VTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNS 1808
              V KTS    T +++  S  ++ P+ ++ P+ + +      +P++  P +       + 
Sbjct: 1964 ACVPKTS-PPATVISSVTSTCSSLPSVSSAPITSGQ------APTTFLPASTSQAQLSSQ 2016

Query: 1809 PLDCGSASP---NKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAH-SNQQQPPGSV 1864
             ++  SA P    KV++  +  A       T N+   ++S++ G+   H S+   P  S 
Sbjct: 2017 KMESFSAVPPTKEKVSTQDQPMANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSN 2076

Query: 1865 SQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP--------VTYPMPQTPMGCP 1916
            +QE   P   S + P  +     P A++S P  +  T+P         T  +PQ  +  P
Sbjct: 2077 TQEEAQPSSVSDLSPMSM-----PFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAP 2131

Query: 1917 QPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHI--KRPHSVPSSVQLPSTLS 1974
            + + +M+       P G+      +A++     ++   N +    P   P++VQL S ++
Sbjct: 2132 RVSHRMQ-------PRGSFYSMVPNATIHQDPQSIFVTNPVTLTPPQGPPAAVQLSSAVN 2184

Query: 1975 TQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLS 2034
              +  Q  ++PANK + P F     F  FS+LF++S   A+  WG   +SS+   ++  +
Sbjct: 2185 IMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSSQVPANQGWGDGPLSSRVATDASFT 2244

Query: 2035 GKSSYLPNSDPLH----QSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGN 2090
             +S++L NS   H      D SKAPGFRPP QR + SP G+ ++D    S + SS  L +
Sbjct: 2245 VQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVSTSPVGLPSIDPSGSSPSSSSAPLAS 2304

Query: 2091 FASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPS 2150
            F S I G +++  G    G P   +FNRQHFSP     P +SASN S++           
Sbjct: 2305 F-SGIPGTRVFLQGPAPVGTP---SFNRQHFSP----HPWTSASNSSTS----------- 2345

Query: 2151 PAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWS 2210
             AP +  LG  K  + SQDRK+P PIGTER ARIRQ G+ A +  G++    VGHSGIWS
Sbjct: 2346 -APPT--LGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGIWS 2402

Query: 2211 FEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAG 2270
            F     ++    W    MGN  +H+ +SDP  FSQHQ MERD +G+V PS  FHQ + +G
Sbjct: 2403 FGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMASG 2462

Query: 2271 YMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNG 2330
            ++DF K  G+P S+YG  +IP    + D  GGP+FNG H  DP+WN +IK++ +STE   
Sbjct: 2463 FVDFSK--GLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD 2520

Query: 2331 PQTVWTGPWAP 2341
             Q     P  P
Sbjct: 2521 AQQASLLPSVP 2531



 Score = 1158 bits (2995), Expect = 0.0
 Identities = 591/701 (84%), Positives = 633/701 (90%), Gaps = 23/701 (3%)

Query: 78  RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122
           RT R    +  +S   +SGGGG G G GGG               GGG  ++ S+E+E  
Sbjct: 42  RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99

Query: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182
                 VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153

Query: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
           GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 154 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 213

Query: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302
           S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 214 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273

Query: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
           TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL  GA+IED
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333

Query: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
           HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
           AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453

Query: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
           AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513

Query: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
           CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 514 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573

Query: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662
           YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH+CTVQFLISKGANVNR TAN
Sbjct: 574 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633

Query: 663 NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722
           NDHTV+SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT+VV YLLDYPNN
Sbjct: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693

Query: 723 LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDK 763
           +LS P  DV+QL PPS D ++ PRVP   L MVVPPQEPD+
Sbjct: 694 VLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDR 734



 Score =  223 bits (568), Expect = 2e-57
 Identities = 141/365 (38%), Positives = 205/365 (56%), Gaps = 38/365 (10%)

Query: 823  DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
            D+++Q+ + + TALT ACAGG  ++V+ LL  GA+IE  ++ G TPL+ AA+AGHV V  
Sbjct: 297  DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355

Query: 883  ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942
            +LLD+GA I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A   
Sbjct: 356  VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415

Query: 943  GYVNIIKILLNAGAEINS-------------------------RTGSKL------GISPL 971
            G+V + ++LL++GA++N                            G+ L      G +PL
Sbjct: 416  GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 475

Query: 972  MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1031
            M AA  GH   V LLL  G++INAQ E  + TALTLAC  G +EV   L+   A++E   
Sbjct: 476  MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC 535

Query: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1091
                TPLMEA+  G+ E+ + LL  GA+V+A    ++ DTALT A + GH    ++L+  
Sbjct: 536  S---TPLMEASQEGHLELVKYLLASGANVHA--TTATGDTALTYACENGHTDVADVLLQA 590

Query: 1092 GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD-AADNRKITPLMAAFRKGHVKV 1150
            GA ++  ++ G TPL  AA  GHL  VQ L+  GA+V+ A  N   T +  A   GH+ V
Sbjct: 591  GADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAV 650

Query: 1151 VRYLV 1155
            V  L+
Sbjct: 651  VELLL 655



 Score =  207 bits (527), Expect = 1e-52
 Identities = 155/484 (32%), Positives = 241/484 (49%), Gaps = 55/484 (11%)

Query: 118  EEEDDDDEEEEVSEVESF-ILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLE 176
            ++ D DDE++     E    +    L +P    +S L  +GT +  +L+ V    Q   +
Sbjct: 905  KDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGT-NSLELQKVSGNQQIVGQ 963

Query: 177  ALLEAAGIGK---LSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQS 233
              +   G  +   +   DG   A P        +++  LD+  AA++      + ++ Q+
Sbjct: 964  PQIAITGHDQGLLVQEPDGLMVATP------AQTLTDTLDDLIAAVSTRVPTGSNSSSQT 1017

Query: 234  DNRSLAEACSEGDVNAVRKLL---IEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 289
                  E+CS+   N   + +        ++ HTE   ++ L LAC+ G+ EL  VL+A 
Sbjct: 1018 TECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIAR 1077

Query: 290  HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSS-TGNTALTYACAGG--- 345
             A +E R  KG  TPL+ AA  GHV +V++LL    D+ AQS  T +T L+ AC+GG   
Sbjct: 1078 DAKIEHRDKKG-FTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 1136

Query: 346  ------------------------------YVDVVKVLLESGASIEDH--NENGHTPLME 373
                                          YV+++K+LL +GA I     ++ G +PLM 
Sbjct: 1137 VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML 1196

Query: 374  AGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDE 433
            A   GHV   +LLL+ G+ IN      + +ALTLAC++G  E+V  LL+  A+ EH+   
Sbjct: 1197 AAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKT 1256

Query: 434  MHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLTLAACGGHVELAALLIERGA 491
              T LMEA   G+ EV R+LLD GA VN P    S ++ LT+AA  GH +   LLI RGA
Sbjct: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316

Query: 492  SLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVAD 551
             ++  N +G TPL  A+  GH ++V LL+  GA+++A  +  + T L  A   G ++V  
Sbjct: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA-ADNRKITPLMSAFRKGHVKVVQ 1375

Query: 552  FLIK 555
            +L+K
Sbjct: 1376 YLVK 1379



 Score =  207 bits (527), Expect = 1e-52
 Identities = 128/336 (38%), Positives = 188/336 (55%), Gaps = 10/336 (2%)

Query: 326  DVNAQS-STGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVAR 384
            D++A + S  +TALT ACAGG+ ++V VL+   A IE  ++ G TPL+ A +AGHV V  
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 385  LLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD 444
            +LL+ G  I   S   K++ L+LAC  G  E+V  LL  GA++EH+    +T L  A   
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 445  GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGASLE-EVNDEGY 501
            G+V + ++LL++GA++N    S    SPL LAA  GHV    LL++ G+ +  ++     
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 502  TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561
            T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG+ EV   L+  GAD+ 
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284

Query: 562  L-----GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616
                     T L  AA +GH +  + L+  GA++      G+T L  A   GH DV  +L
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344

Query: 617  LQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
            +QAGAD++       TPLM A R GHV  VQ+L+ +
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  207 bits (526), Expect = 1e-52
 Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)

Query: 835  ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 894
            +L  AC+ G    V+ LL+ G S+    ++G + L LA +AG+  + ++LL   A++E +
Sbjct: 208  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 895  SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 954
              +   TPL  A SGG  ++V+LLL   A+   ++ +  T L+ A +GG+V+I+K+LLN 
Sbjct: 268  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 955  GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1014
            GA I     ++ G +PLM AA  GH    ++LLD G+ IN      + +ALTLAC++G  
Sbjct: 328  GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385

Query: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1074
            ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++ LT
Sbjct: 386  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 443

Query: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1134
            +AA  GH +   LLI RGA+++  N +G TPL  AA  GH ++V LL+  GA+++A    
Sbjct: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 1135 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1155
                                             TPLM A ++GH+++V+YL+
Sbjct: 504  TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555



 Score =  189 bits (481), Expect = 2e-47
 Identities = 192/692 (27%), Positives = 301/692 (43%), Gaps = 97/692 (14%)

Query: 654  ANVNRTTANNDHTV-------LSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 706
            A + R  A N H         L+ AC+ G +  V  LL  G       ++G ++L  A  
Sbjct: 188  AALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACS 247

Query: 707  GGHTSVVCYLLDYPNNLLS-APPPDVTQLTPPSH----DLNRAPRVPVQALPMVVPPQEP 761
             G+  +   LL    N+       D+T L   S     D+       V+ L +       
Sbjct: 248  AGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDI-------VKLLLLHDADVNS 300

Query: 762  DKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPA 821
                 N A T       V      ++        A+I        +P++  ++   +  A
Sbjct: 301  QSATGNTALTYACAGGFVDIVKVLLNE------GANIEDHNENGHTPLMEAASAGHVEVA 354

Query: 822  ---IDIDA--QTESNH--DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAAT 874
               +D  A   T SN   ++ALTLAC  GH ++V+ LLE GA  EH+  +  T L+ A  
Sbjct: 355  RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414

Query: 875  AGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYT 934
             GHV V  +LLD+GA +   ++ + ++PL+LA  GG  E+  LL+ RGAN E  N   YT
Sbjct: 415  DGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473

Query: 935  PLSLAASGGYVNIIKILLNAGAEINSRTGS----------------------------KL 966
            PL  AA  G+  ++ +LL  GA IN++T                              +L
Sbjct: 474  PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 533

Query: 967  GIS-PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKA 1025
            G S PLM A+  GH   VK LL  G++++A   T  +TALT AC  G T+V  +LL   A
Sbjct: 534  GCSTPLMEASQEGHLELVKYLLASGANVHATTATG-DTALTYACENGHTDVADVLLQAGA 592

Query: 1026 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1085
            ++EH ++ G TPLM+AA  G+    + L+ KGA+VN     +   T +++A   GH    
Sbjct: 593  DLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVV 651

Query: 1086 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFR- 1144
            ELL+  GA    R K G+T L  AA GGH +VV  L+    +V +     ++ L    + 
Sbjct: 652  ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQD 711

Query: 1145 -------KGHVKVVRYLVKEVNQFPSD------------SECMRYIATITDKEMLKKCH- 1184
                     H   +    +E ++   +            S+       + D+++L   H 
Sbjct: 712  QSQVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHP 771

Query: 1185 -LCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEE 1243
               +E IV+  + +  E  +  S       +EK + +S  L       K K +  KK  E
Sbjct: 772  YQPLECIVEETEGKLNELGQRISA------IEKAQLKSLELIQGEPLNKDKIEELKKNRE 825

Query: 1244 QRRKLEEIEAKNKENFELQAAQEKEKLKVEDE 1275
                 E+++ K K   ELQ  + + ++K + +
Sbjct: 826  -----EQVQKKKKILKELQKVERQLQMKTQQQ 852



 Score =  183 bits (465), Expect = 2e-45
 Identities = 128/334 (38%), Positives = 179/334 (53%), Gaps = 11/334 (3%)

Query: 360  IEDHNENGH-TPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVR 418
            I+ H E+ H T L  A + GH E+  +L+   A I  H ++   + L LA   GH+ +V 
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIE-HRDKKGFTPLILAATAGHVGVVE 1105

Query: 419  FLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 477
             LL+ G D E +++    T L  AC  G  EV  LLL  GA       S  +PL+LAA G
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 478  GHVELAALLIERGASLEEVNDE--GYTPLMEAAREGHEEMVALLLGQGANINAQTEETQE 535
            G+V +  +L+  GA +        G +PLM AA  GH   V LLL  G++INAQ E  + 
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 536  TALTLACCGGFLEVADFLIKAGADIELGCST---PLMEAAQEGHLELVKYLLAAGANVHA 592
            TALTLAC  G  EV   L+   A++E    T   PLMEAA  G+ E+ + LL  GA+V+A
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1285

Query: 593  --TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650
                ++ DTALT A + GH    ++L+  GA ++  ++ G TPL  A+  GH   VQ L+
Sbjct: 1286 PPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1345

Query: 651  SKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
              GA+V+    N   T L  A   GH+ VV+ L+
Sbjct: 1346 QAGADVD-AADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score =  175 bits (443), Expect = 5e-43
 Identities = 129/360 (35%), Positives = 192/360 (53%), Gaps = 20/360 (5%)

Query: 655  NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
            +++  T +N  T L+LACAGGH  +V +L+A  A   HR K G T LI AA  GH  VV 
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 715  YLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPI 774
             LLD   ++      + T+ TP    L+ A     Q +  ++  +  +K   NV+   P+
Sbjct: 1106 ILLDKGGDI--EAQSERTKDTP----LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1159

Query: 775  RNKAVSG---------RASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDID 825
               A  G          A A  N+ T S    IS       +  + P+  L +    DI+
Sbjct: 1160 SLAASGGYVNIIKILLNAGAEINSRTGS-KLGISPLMLAAMNGHV-PAVKLLLDMGSDIN 1217

Query: 826  AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885
            AQ E+N +TALTLAC  G  E+V  LL+R A++EHR K G TPL+ AA+ G+  V  +LL
Sbjct: 1218 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1277

Query: 886  DNGADIEAQS-ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGY 944
            D GAD+ A     ++DT L++A   G  +  ELL+ RGA+ + RN    TPL LA++GG+
Sbjct: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337

Query: 945  VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTA 1004
             +++++L+ AGA++++    K  I+PLM A   GH   V+ L+   +   + IE  R  A
Sbjct: 1338 FDVVQLLVQAGADVDAADNRK--ITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIA 1395



 Score =  154 bits (388), Expect = 1e-36
 Identities = 114/333 (34%), Positives = 161/333 (48%), Gaps = 11/333 (3%)

Query: 593  TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
            T +  DTALT AC  GH ++  VL+   A +EH  + G TPL+ AA AGHV  V+ L+ K
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110

Query: 653  GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
            G ++   +     T LSLAC+GG   VV+LLLA GA+  HR     T L  AA GG+ ++
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170

Query: 713  VCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTL 772
            +  LL+    + S     +         +N         L M        +   N A TL
Sbjct: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230

Query: 773  PIRNKAVSGRASAMS-----NTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDA- 826
                    GRA  +S            A +   P     S   +    + +    D++A 
Sbjct: 1231 ----ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286

Query: 827  QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886
               S+ DTALT+A   GH +  + L+ RGA I+ R+KKG TPL LA+  GH  VV++L+ 
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346

Query: 887  NGADIEAQSERTKDTPLSLACSGGRQEVVELLL 919
             GAD++A   R K TPL  A   G  +VV+ L+
Sbjct: 1347 AGADVDAADNR-KITPLMSAFRKGHVKVVQYLV 1378



 Score =  131 bits (330), Expect = 7e-30
 Identities = 88/234 (37%), Positives = 123/234 (52%), Gaps = 7/234 (2%)

Query: 502  TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561
            T L  A   GHEE+V++L+ + A I  + ++   T L LA   G + V + L+  G DIE
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHR-DKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 562  LGCS----TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL 617
                    TPL  A   G  E+V  LLA GAN      +  T L+ A   G+ ++  +LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175

Query: 618  QAGADLEHE--SEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGG 675
             AGA++     S+ G +PLM AA  GHV  V+ L+  G+++N     N +T L+LAC  G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235

Query: 676  HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPP 729
               VV LLL   A+  HR K G T L+EAA GG+  V   LLD   ++ + P P
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1289



 Score = 72.0 bits (175), Expect = 6e-12
 Identities = 53/165 (32%), Positives = 82/165 (49%), Gaps = 6/165 (3%)

Query: 995  AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVL 1053
            A  E  R    +++C     E  + L   KA   H A +     L EA S G     R L
Sbjct: 167  ADPEVLRRLTSSVSC--ALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKL 224

Query: 1054 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN-TPLWLAANG 1112
            LD+G  VN        ++ L +A   G+Y+  ++L+   A+++ R  KG+ TPL  A++G
Sbjct: 225  LDEGRSVNEHT--EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG 282

Query: 1113 GHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
            G+LD+V+LL+   ADV++      T L  A   G V +V+ L+ E
Sbjct: 283  GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 31/146 (21%), Positives = 55/146 (37%), Gaps = 18/146 (12%)

Query: 71   HHKAKRNRTCRPPSSSE----------SSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE 120
            + K K+N+T   P ++           +   +D +   G   GGG GG   S N    + 
Sbjct: 1542 NRKNKKNKTKETPPTAHLILPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDC 1601

Query: 121  DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE 180
            + +      S+  +F++D +  + P L   S+   + TA          +TQ RLE  + 
Sbjct: 1602 NSESSSGGKSQELNFVMDVNSSKYPSLLLHSQEEKTSTATS--------KTQTRLEGEVT 1653

Query: 181  AAGIGKLSTADGKAFADPEVLRRLTS 206
               +           + P +   LTS
Sbjct: 1654 PNSLSTSYKTVSLPLSSPNIKLNLTS 1679


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  917 bits (2370), Expect = 0.0
 Identities = 479/586 (81%), Positives = 516/586 (88%), Gaps = 24/586 (4%)

Query: 78  RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122
           RT R    +  +S   +SGGGG G G GGG               GGG  ++ S+E+E  
Sbjct: 42  RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99

Query: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182
                 VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153

Query: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
           GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 154 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 213

Query: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302
           S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 214 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273

Query: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
           TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL  GA+IED
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333

Query: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
           HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
           AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453

Query: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
           AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513

Query: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
           CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 514 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573

Query: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648
           YACENGHTDVADVLLQAGADL+ + E  +T L     A H   V F
Sbjct: 574 YACENGHTDVADVLLQAGADLD-KQEDMKTILEGIDPAKHQVRVAF 618



 Score =  246 bits (628), Expect = 2e-64
 Identities = 150/370 (40%), Positives = 219/370 (59%), Gaps = 10/370 (2%)

Query: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK 430
           L EA S G V   R LL+ G  +N H+ E  ES L LAC  G+ E+ + LL   A+ E +
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 431 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
            ++   T LM A   G++++ +LLL   A VN  + +  + LT A  GG V++  +L+  
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 490 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV 549
           GA++E+ N+ G+TPLMEAA  GH E+  +LL  GA IN  + E +E+ALTLAC  G L++
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387

Query: 550 ADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACE 606
             FL++AGAD E       T LMEA  +GH+E+ + LL +GA V+    + ++ LT A  
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447

Query: 607 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666
            GH ++A +L++ GA+LE  ++ G TPLM+AAR GH   V  L+++GAN+N  T     T
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 507

Query: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTSVVCYLLDYPNNLLS 725
            L+LAC GG   V + L+  GAD    ++ G ST L+EA++ GH  +V YLL    N+ +
Sbjct: 508 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 563

Query: 726 APPPDVTQLT 735
                 T LT
Sbjct: 564 TTATGDTALT 573



 Score =  207 bits (526), Expect = 1e-52
 Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)

Query: 835  ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 894
            +L  AC+ G    V+ LL+ G S+    ++G + L LA +AG+  + ++LL   A++E +
Sbjct: 208  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 895  SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 954
              +   TPL  A SGG  ++V+LLL   A+   ++ +  T L+ A +GG+V+I+K+LLN 
Sbjct: 268  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 955  GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1014
            GA I     ++ G +PLM AA  GH    ++LLD G+ IN      + +ALTLAC++G  
Sbjct: 328  GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385

Query: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1074
            ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++ LT
Sbjct: 386  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 443

Query: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1134
            +AA  GH +   LLI RGA+++  N +G TPL  AA  GH ++V LL+  GA+++A    
Sbjct: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 1135 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1155
                                             TPLM A ++GH+++V+YL+
Sbjct: 504  TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555



 Score =  198 bits (503), Expect = 6e-50
 Identities = 118/314 (37%), Positives = 182/314 (57%), Gaps = 10/314 (3%)

Query: 823  DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
            D+++Q+ + + TALT ACAGG  ++V+ LL  GA+IE  ++ G TPL+ AA+AGHV V  
Sbjct: 297  DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355

Query: 883  ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942
            +LLD+GA I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A   
Sbjct: 356  VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415

Query: 943  GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1002
            G+V + ++LL++GA++N    S    SPL LAA  GH     LL++ G+++  ++     
Sbjct: 416  GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEGY 472

Query: 1003 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061
            T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG++EV   L+  GAD+ 
Sbjct: 473  TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 532

Query: 1062 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
                     T L  A+ +GH +  + L+  GA++      G+T L  A   GH DV  +L
Sbjct: 533  L-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587

Query: 1122 VQAGADVDAADNRK 1135
            +QAGAD+D  ++ K
Sbjct: 588  LQAGADLDKQEDMK 601



 Score =  173 bits (439), Expect = 2e-42
 Identities = 118/324 (36%), Positives = 179/324 (55%), Gaps = 9/324 (2%)

Query: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
            T L  A +GG+ ++V+ LL   A +  +   G T L  A   G V +V++LL+ GA+IE 
Sbjct: 274  TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333

Query: 894  QSERTKDTPLSLACSGGRQEVVELLLARGAN-KEHRNVSDYTPLSLAASGGYVNIIKILL 952
             +E    TPL  A S G  EV  +LL  GA    H N    + L+LA   G++++++ LL
Sbjct: 334  HNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 953  NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012
             AGA+   +T      + LM A M+GH    +LLLD G+ +N   + +  + LTLA   G
Sbjct: 393  EAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGG 449

Query: 1013 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1072
              E+ +LL++R AN+E     G TPLMEAA  G+ E+  +LL +GA++NA     +++TA
Sbjct: 450  HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQETA 508

Query: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1132
            LT+A   G  +  + LI  GA I++     +TPL  A+  GHL++V+ L+ +GA+V A  
Sbjct: 509  LTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATT 565

Query: 1133 NRKITPLMAAFRKGHVKVVRYLVK 1156
                T L  A   GH  V   L++
Sbjct: 566  ATGDTALTYACENGHTDVADVLLQ 589



 Score =  156 bits (394), Expect = 3e-37
 Identities = 103/288 (35%), Positives = 150/288 (52%), Gaps = 36/288 (12%)

Query: 903  LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 962
            L+ ACS G    V  LL  G +         + L LA S GY  + ++LL   A +  R 
Sbjct: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR- 267

Query: 963  GSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLD 1022
            G+K  I+PLM A+  G+   VKLLL   +D+N+Q  T  NTALT AC  G  ++V +LL+
Sbjct: 268  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATG-NTALTYACAGGFVDIVKVLLN 326

Query: 1023 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1082
              AN+E   + G TPLMEAAS G+ EV RVLLD GA +N       +++ALT+A  KGH 
Sbjct: 327  EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKGHL 385

Query: 1083 ---------------------------------KFCELLIGRGAHIDVRNKKGNTPLWLA 1109
                                             +   LL+  GA +++      +PL LA
Sbjct: 386  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 445

Query: 1110 ANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
            A GGH+++  LL++ GA+++  ++   TPLM A R+GH ++V  L+ +
Sbjct: 446  ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493



 Score =  114 bits (284), Expect = 1e-24
 Identities = 121/434 (27%), Positives = 169/434 (38%), Gaps = 84/434 (19%)

Query: 504 LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG 563
           L EA  +G    V  LL +G ++N  TEE  E+ L LAC  G+ E+A             
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELA------------- 254

Query: 564 CSTPLMEAAQEGHLELVKYLLAAGANVHATTATGD-TALTYACENGHTDVADVLLQAGAD 622
                            + LLA  ANV      GD T L  A   G+ D+  +LL   AD
Sbjct: 255 -----------------QVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 297

Query: 623 LEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVEL 682
           +  +S  G T L  A   G V  V+ L+++GAN+     N  HT L  A + GH+ V  +
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG-HTPLMEAASAGHVEVARV 356

Query: 683 LLAHGAD-PTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDL 741
           LL HGA   TH  +   + L  A   GH  +V +LL+   +         T L     D 
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416

Query: 742 N-RAPRVPVQALPMVVPPQEPDKPPANVAT--------TLPIRNKAVSGRASAMSNTPTH 792
           +    R+ + +   V  P +  + P  +A          L I   A     +    TP  
Sbjct: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476

Query: 793 SIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGG--------- 843
             A    +               L +    +I+AQTE   +TALTLAC GG         
Sbjct: 477 EAAREGHEEMVA-----------LLLAQGANINAQTEETQETALTLACCGGFSEVADFLI 525

Query: 844 ---------------------HEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
                                H ELV+ LL  GA++      G T L  A   GH  V +
Sbjct: 526 KAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 585

Query: 883 ILLDNGADIEAQSE 896
           +LL  GAD++ Q +
Sbjct: 586 VLLQAGADLDKQED 599



 Score = 72.4 bits (176), Expect = 5e-12
 Identities = 60/204 (29%), Positives = 87/204 (42%), Gaps = 5/204 (2%)

Query: 522 QGANINAQTEETQET--ALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLEL 579
           +GA++     ETQ    AL  A   G L  AD    A  ++    ++ +  A  E    L
Sbjct: 131 EGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAAL 190

Query: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
            +       N H        +L  AC +G  +    LL  G  +   +E G + L  A  
Sbjct: 191 TRM---KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACS 247

Query: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
           AG+    Q L++  ANV       D T L  A +GG+L +V+LLL H AD   +   G+T
Sbjct: 248 AGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNT 307

Query: 700 MLIEAAKGGHTSVVCYLLDYPNNL 723
            L  A  GG   +V  LL+   N+
Sbjct: 308 ALTYACAGGFVDIVKVLLNEGANI 331


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  887 bits (2293), Expect = 0.0
 Identities = 468/586 (79%), Positives = 505/586 (86%), Gaps = 35/586 (5%)

Query: 78  RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122
           RT R    +  +S   +SGGGG G G GGG               GGG  ++ S+E+E  
Sbjct: 42  RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99

Query: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182
                 VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153

Query: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
                      AFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 154 -----------AFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 202

Query: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302
           S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 203 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 262

Query: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
           TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL  GA+IED
Sbjct: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322

Query: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
           HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382

Query: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
           AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 442

Query: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
           AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 443 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 502

Query: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
           CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 503 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 562

Query: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648
           YACENGHTDVADVLLQAGADL+ + E  +T L     A H   V F
Sbjct: 563 YACENGHTDVADVLLQAGADLD-KQEDMKTILEGIDPAKHQVRVAF 607



 Score =  246 bits (628), Expect = 2e-64
 Identities = 150/370 (40%), Positives = 219/370 (59%), Gaps = 10/370 (2%)

Query: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK 430
           L EA S G V   R LL+ G  +N H+ E  ES L LAC  G+ E+ + LL   A+ E +
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 256

Query: 431 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
            ++   T LM A   G++++ +LLL   A VN  + +  + LT A  GG V++  +L+  
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316

Query: 490 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV 549
           GA++E+ N+ G+TPLMEAA  GH E+  +LL  GA IN  + E +E+ALTLAC  G L++
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376

Query: 550 ADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACE 606
             FL++AGAD E       T LMEA  +GH+E+ + LL +GA V+    + ++ LT A  
Sbjct: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436

Query: 607 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666
            GH ++A +L++ GA+LE  ++ G TPLM+AAR GH   V  L+++GAN+N  T     T
Sbjct: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496

Query: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTSVVCYLLDYPNNLLS 725
            L+LAC GG   V + L+  GAD    ++ G ST L+EA++ GH  +V YLL    N+ +
Sbjct: 497 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 552

Query: 726 APPPDVTQLT 735
                 T LT
Sbjct: 553 TTATGDTALT 562



 Score =  207 bits (526), Expect = 1e-52
 Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)

Query: 835  ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 894
            +L  AC+ G    V+ LL+ G S+    ++G + L LA +AG+  + ++LL   A++E +
Sbjct: 197  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256

Query: 895  SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 954
              +   TPL  A SGG  ++V+LLL   A+   ++ +  T L+ A +GG+V+I+K+LLN 
Sbjct: 257  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316

Query: 955  GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1014
            GA I     ++ G +PLM AA  GH    ++LLD G+ IN      + +ALTLAC++G  
Sbjct: 317  GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374

Query: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1074
            ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++ LT
Sbjct: 375  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 432

Query: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1134
            +AA  GH +   LLI RGA+++  N +G TPL  AA  GH ++V LL+  GA+++A    
Sbjct: 433  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492

Query: 1135 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1155
                                             TPLM A ++GH+++V+YL+
Sbjct: 493  TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 544



 Score =  198 bits (503), Expect = 6e-50
 Identities = 118/314 (37%), Positives = 182/314 (57%), Gaps = 10/314 (3%)

Query: 823  DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
            D+++Q+ + + TALT ACAGG  ++V+ LL  GA+IE  ++ G TPL+ AA+AGHV V  
Sbjct: 286  DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 344

Query: 883  ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942
            +LLD+GA I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A   
Sbjct: 345  VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 404

Query: 943  GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1002
            G+V + ++LL++GA++N    S    SPL LAA  GH     LL++ G+++  ++     
Sbjct: 405  GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEGY 461

Query: 1003 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061
            T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG++EV   L+  GAD+ 
Sbjct: 462  TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 521

Query: 1062 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
                     T L  A+ +GH +  + L+  GA++      G+T L  A   GH DV  +L
Sbjct: 522  L-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 576

Query: 1122 VQAGADVDAADNRK 1135
            +QAGAD+D  ++ K
Sbjct: 577  LQAGADLDKQEDMK 590



 Score =  173 bits (439), Expect = 2e-42
 Identities = 118/324 (36%), Positives = 179/324 (55%), Gaps = 9/324 (2%)

Query: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
            T L  A +GG+ ++V+ LL   A +  +   G T L  A   G V +V++LL+ GA+IE 
Sbjct: 263  TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322

Query: 894  QSERTKDTPLSLACSGGRQEVVELLLARGAN-KEHRNVSDYTPLSLAASGGYVNIIKILL 952
             +E    TPL  A S G  EV  +LL  GA    H N    + L+LA   G++++++ LL
Sbjct: 323  HNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 381

Query: 953  NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012
             AGA+   +T      + LM A M+GH    +LLLD G+ +N   + +  + LTLA   G
Sbjct: 382  EAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGG 438

Query: 1013 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1072
              E+ +LL++R AN+E     G TPLMEAA  G+ E+  +LL +GA++NA     +++TA
Sbjct: 439  HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQETA 497

Query: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1132
            LT+A   G  +  + LI  GA I++     +TPL  A+  GHL++V+ L+ +GA+V A  
Sbjct: 498  LTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATT 554

Query: 1133 NRKITPLMAAFRKGHVKVVRYLVK 1156
                T L  A   GH  V   L++
Sbjct: 555  ATGDTALTYACENGHTDVADVLLQ 578



 Score =  167 bits (422), Expect = 1e-40
 Identities = 108/286 (37%), Positives = 146/286 (51%), Gaps = 22/286 (7%)

Query: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV 496
           AL+EA      EV R L  S                  +C      AAL   +  +    
Sbjct: 148 ALLEAAAFADPEVLRRLTSS-----------------VSCALDEAAAALTRMKAENSHNA 190

Query: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556
                  L EA  +G    V  LL +G ++N  TEE  E+ L LAC  G+ E+A  L+  
Sbjct: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 249

Query: 557 GADIE----LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDV 612
            A++E     G  TPLM A+  G+L++VK LL   A+V++ +ATG+TALTYAC  G  D+
Sbjct: 250 HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDI 309

Query: 613 ADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC 672
             VLL  GA++E  +E G TPLM+AA AGHV   + L+  GA +N  +     + L+LAC
Sbjct: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369

Query: 673 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
             GHL +V  LL  GAD  H+  +  T L+EA   GH  V   LLD
Sbjct: 370 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415



 Score =  156 bits (394), Expect = 3e-37
 Identities = 103/288 (35%), Positives = 150/288 (52%), Gaps = 36/288 (12%)

Query: 903  LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 962
            L+ ACS G    V  LL  G +         + L LA S GY  + ++LL   A +  R 
Sbjct: 198  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR- 256

Query: 963  GSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLD 1022
            G+K  I+PLM A+  G+   VKLLL   +D+N+Q  T  NTALT AC  G  ++V +LL+
Sbjct: 257  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATG-NTALTYACAGGFVDIVKVLLN 315

Query: 1023 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1082
              AN+E   + G TPLMEAAS G+ EV RVLLD GA +N       +++ALT+A  KGH 
Sbjct: 316  EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKGHL 374

Query: 1083 ---------------------------------KFCELLIGRGAHIDVRNKKGNTPLWLA 1109
                                             +   LL+  GA +++      +PL LA
Sbjct: 375  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 434

Query: 1110 ANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
            A GGH+++  LL++ GA+++  ++   TPLM A R+GH ++V  L+ +
Sbjct: 435  ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 44/135 (32%), Positives = 62/135 (45%)

Query: 589 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648
           N H        +L  AC +G  +    LL  G  +   +E G + L  A  AG+    Q 
Sbjct: 186 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245

Query: 649 LISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 708
           L++  ANV       D T L  A +GG+L +V+LLL H AD   +   G+T L  A  GG
Sbjct: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305

Query: 709 HTSVVCYLLDYPNNL 723
              +V  LL+   N+
Sbjct: 306 FVDIVKVLLNEGANI 320


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  308 bits (789), Expect = 4e-83
 Identities = 263/826 (31%), Positives = 393/826 (47%), Gaps = 58/826 (7%)

Query: 219  LTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAG 278
            +T M  +S +NA      S   A   G+++ V + L  G  +N   + G + L LA   G
Sbjct: 1    MTTMLQKSDSNA------SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEG 54

Query: 279  YYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTAL 338
            +  L Q LL   ++V+    KG+ T L  A+  G  ++VK+L+   A++NAQS  G T L
Sbjct: 55   HVGLVQELLGRGSSVDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113

Query: 339  TYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN 398
              A    ++DVVK LLE+GA+     E+G TPL  A   GH +   +LLEN         
Sbjct: 114  YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT-----KG 168

Query: 399  EFKESALTLACYKGHLEMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVA 450
            + +  AL +A  K   +    LL  +  AD + K      T+   T L  A   G+V VA
Sbjct: 169  KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228

Query: 451  RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAARE 510
             LLL+ GA V+  A +  +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR 
Sbjct: 229  TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288

Query: 511  GHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA---DIELGCSTP 567
            GH+++V LLL +GA + A+T+    + L +A  G  +E    L++  A   D+ L   T 
Sbjct: 289  GHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347

Query: 568  LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 627
            L  AA  GH  + K LL   AN +A    G T L  AC+     V ++L++ GA ++  +
Sbjct: 348  LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407

Query: 628  EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687
            E G TP+  AA  GH+  V  L+  GA+ + T    + T L +A   G + VV  LL +G
Sbjct: 408  ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAARAGQVEVVRCLLRNG 466

Query: 688  ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRV 747
            A    R ++  T L  A++ G T +V  LL +    ++ P    T    P H   R  +V
Sbjct: 467  ALVDARAREEQTPLHIASRLGKTEIVQLLLQH----MAHPDAATTNGYTPLHISAREGQV 522

Query: 748  PVQALPM-------------VVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSI 794
             V ++ +               P     K  +     L ++ +A +  A     TP H +
Sbjct: 523  DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH-V 581

Query: 795  AASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLER 854
            AA     +           A+L +       A T  N  T L +A      ++  TLL  
Sbjct: 582  AAHYDNQKV----------ALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNY 630

Query: 855  GASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEV 914
            GA      K+G TPL LA+  GH  +V +LLD GA+I   S ++  T L LA    +  V
Sbjct: 631  GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNV 689

Query: 915  VELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA 974
             ++L   GA+++      YTPL +A   G V ++  LL  GA +N++T  K G +PL  A
Sbjct: 690  ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT--KNGYTPLHQA 747

Query: 975  AMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1020
            A  GHT  + +LL  G+  NA    N NTAL +A   G   VV  L
Sbjct: 748  AQQGHTHIINVLLQHGAKPNA-TTANGNTALAIAKRLGYISVVDTL 792



 Score =  284 bits (726), Expect = 8e-76
 Identities = 286/1001 (28%), Positives = 452/1001 (45%), Gaps = 79/1001 (7%)

Query: 408  ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
            A   G+L+ V   L+ G D          AL  A  +GHV + + LL  G+ V+      
Sbjct: 17   AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76

Query: 468  ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
             + L +A+  G  E+  +L++ GA++   +  G+TPL  AA+E H ++V  LL  GAN +
Sbjct: 77   NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136

Query: 528  AQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLME-AAQEGHLELVKYLLAA 586
              TE+   T L +A   G  +    L++   D +     P +  AA++   +    LL  
Sbjct: 137  TATEDGF-TPLAVALQQGHNQAVAILLEN--DTKGKVRLPALHIAARKDDTKSAALLLQN 193

Query: 587  GAN--------VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 638
              N        V+ TT +G T L  A   G+ +VA +LL  GA ++  +  G TPL  A+
Sbjct: 194  DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 253

Query: 639  RAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGS 698
            + G+   V+ L+ +G  ++  T +   T L  A   GH  VVELLL  GA    R K+G 
Sbjct: 254  KRGNTNMVKLLLDRGGQIDAKTRDG-LTPLHCAARSGHDQVVELLLERGAPLLARTKNGL 312

Query: 699  TMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPP 758
            + L  AA+G H   V +LL +      AP  DVT       D   A  V           
Sbjct: 313  SPLHMAAQGDHVECVKHLLQH-----KAPVDDVTL------DYLTALHVAAHC------- 354

Query: 759  QEPDKPPANVATTLPIRNKAVSGRASAMSN-TPTHSIAASISQPQTPTPSPIISPSAMLP 817
                    +   T  + +K  +  A A++  TP H IA   ++         I    +L 
Sbjct: 355  -------GHYRVTKLLLDKRANPNARALNGFTPLH-IACKKNR---------IKVMELLV 397

Query: 818  IYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH 877
             Y A  I A TES   T + +A   GH  +V  LL+ GAS +  + +G T L +AA AG 
Sbjct: 398  KYGA-SIQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 455

Query: 878  VGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLS 937
            V VV  LL NGA ++A++ R + TPL +A   G+ E+V+LLL   A+ +    + YTPL 
Sbjct: 456  VEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 514

Query: 938  LAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI 997
            ++A  G V++  +LL AGA  +  T  K G +PL +AA  G     KLLL   +  ++  
Sbjct: 515  ISAREGQVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 572

Query: 998  ETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG 1057
            + N  T L +A      +V  LLL++ A+    AK G TPL  AA     ++   LL+ G
Sbjct: 573  K-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYG 631

Query: 1058 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDV 1117
            A+ N   V     T L +A+ +GH     LL+ +GA+I +  K G T L LAA    ++V
Sbjct: 632  AETNI--VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 689

Query: 1118 VQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDK 1177
              +L + GAD DA      TPL+ A   G+VK+V +L+K+      +++       +   
Sbjct: 690  ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV--NAKTKNGYTPLHQA 747

Query: 1178 EMLKKCHLCMESIVQAKDRQAAEANKNASILLEE-------LDLEKLREESRRLALAAKR 1230
                  H+    +       A  AN N ++ + +       +D  K+  E          
Sbjct: 748  AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT 807

Query: 1231 EKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTT 1290
            EK       K        E ++  ++E  +       E L+ ED  E L +    ++   
Sbjct: 808  EKH------KLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKE-LGDDSLPSSQFL 860

Query: 1291 IGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNG 1350
             G++    +L G    R++++ + SS R +  +  +      + DD + I   Q   +  
Sbjct: 861  DGMNYLRYSLEGG---RSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAK 917

Query: 1351 ESKSSSTSESGDS---DNMRISSCSDESSNSNSSRKSDNHS 1388
            E++ +S   S  +   DN+ +SS    S  ++   + DN S
Sbjct: 918  EAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSS 958



 Score =  199 bits (506), Expect = 3e-50
 Identities = 160/483 (33%), Positives = 241/483 (49%), Gaps = 16/483 (3%)

Query: 193 KAFADPEVLRRLTS---SVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA 249
           KA  D   L  LT+   +  C        L   RA   A A  +    L  AC +  +  
Sbjct: 334 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 392

Query: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309
           +  L+  G S+   TE G + + +A   G+  +  +LL   A+ +   I+G+ T L  AA
Sbjct: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAA 451

Query: 310 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT 369
             G V++V+ LL + A V+A++    T L  A   G  ++V++LL+  A  +    NG+T
Sbjct: 452 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 511

Query: 370 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKE--SALTLACYKGHLEMVRFLLEAGADQ 427
           PL  +   G V+VA +LLE GA    HS   K+  + L +A   G L++ + LL+  A  
Sbjct: 512 PLHISAREGQVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 568

Query: 428 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 487
           +       T L  A    + +VA LLL+ GA  +  A +  +PL +AA    +++A+ L+
Sbjct: 569 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 628

Query: 488 ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
             GA    V  +G TPL  A++EGH +MV LLL +GANI+  T+    T+L LA     +
Sbjct: 629 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKV 687

Query: 548 EVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604
            VAD L K GAD +       TPL+ A   G++++V +LL  GANV+A T  G T L  A
Sbjct: 688 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 747

Query: 605 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL--ISKGANVNRTTAN 662
            + GHT + +VLLQ GA     +  G T L  A R G++  V  L  +++      TT  
Sbjct: 748 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT 807

Query: 663 NDH 665
             H
Sbjct: 808 EKH 810



 Score =  163 bits (412), Expect = 2e-39
 Identities = 112/354 (31%), Positives = 193/354 (54%), Gaps = 20/354 (5%)

Query: 829  ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 888
            +S+ + +   A   G+ + V   L+ G  I   ++ G   L LAA  GHVG+V+ LL  G
Sbjct: 7    KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66

Query: 889  ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 948
            + +++ +++  +T L +A   G+ EVV++L+  GAN   ++ + +TPL +AA   +++++
Sbjct: 67   SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125

Query: 949  KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1008
            K LL  GA  N  T ++ G +PL +A   GH  AV +LL+  +D   ++   R  AL +A
Sbjct: 126  KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 178

Query: 1009 CFQGRTEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1060
              +  T+  +LLL    N + ++K        +G TPL  AA  G   V  +LL++GA V
Sbjct: 179  ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238

Query: 1061 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120
            +      +  T L +A+ +G+    +LL+ RG  ID + + G TPL  AA  GH  VV+L
Sbjct: 239  DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296

Query: 1121 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATI 1174
            L++ GA + A     ++PL  A +  HV+ V++L++  ++ P D   + Y+  +
Sbjct: 297  LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 348



 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 53/180 (29%), Positives = 92/180 (51%), Gaps = 10/180 (5%)

Query: 1039 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1098
            + AA  G  +     L  G D+N      +   AL +AA +GH    + L+GRG+ +D  
Sbjct: 15   LRAARAGNLDKVVEYLKGGIDINT--CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72

Query: 1099 NKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE- 1157
             KKGNT L +A+  G  +VV++LV+ GA+++A      TPL  A ++ H+ VV+YL++  
Sbjct: 73   TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132

Query: 1158 VNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAA-------EANKNASILLE 1210
             NQ  +  +    +A    +   +   + +E+  + K R  A       +  K+A++LL+
Sbjct: 133  ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192



 Score = 32.0 bits (71), Expect = 7.4
 Identities = 16/59 (27%), Positives = 30/59 (50%)

Query: 1097 VRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155
            ++    N     AA  G+LD V   ++ G D++  +   +  L  A ++GHV +V+ L+
Sbjct: 5    LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL 63


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  308 bits (788), Expect = 5e-83
 Identities = 259/810 (31%), Positives = 386/810 (47%), Gaps = 52/810 (6%)

Query: 235  NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 294
            N S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+
Sbjct: 32   NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91

Query: 295  DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354
                KG+ T L  A+  G  ++VK+L+   A++NAQS  G T L  A    ++DVVK LL
Sbjct: 92   SATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150

Query: 355  ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414
            E+GA+     E+G TPL  A   GH +   +LLEN         + +  AL +A  K   
Sbjct: 151  ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT-----KGKVRLPALHIAARKDDT 205

Query: 415  EMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466
            +    LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +
Sbjct: 206  KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265

Query: 467  FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526
              +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA +
Sbjct: 266  GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325

Query: 527  NAQTEETQETALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYL 583
             A+T+    + L +A  G  +E    L++  A   D+ L   T L  AA  GH  + K L
Sbjct: 326  LARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384

Query: 584  LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHV 643
            L   AN +A    G T L  AC+     V ++L++ GA ++  +E G TP+  AA  GH+
Sbjct: 385  LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444

Query: 644  CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703
              V  L+  GA+ + T    + T L +A   G + VV  LL +GA    R ++  T L  
Sbjct: 445  NIVLLLLQNGASPDVTNIRGE-TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503

Query: 704  AAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPM--------- 754
            A++ G T +V  LL +    ++ P    T    P H   R  +V V ++ +         
Sbjct: 504  ASRLGKTEIVQLLLQH----MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 559

Query: 755  ----VVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPII 810
                  P     K  +     L ++ +A +  A     TP H +AA     +        
Sbjct: 560  TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH-VAAHYDNQKV------- 611

Query: 811  SPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLI 870
               A+L +       A T  N  T L +A      ++  TLL  GA      K+G TPL 
Sbjct: 612  ---ALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 667

Query: 871  LAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930
            LA+  GH  +V +LLD GA+I   S ++  T L LA    +  V ++L   GA+++    
Sbjct: 668  LASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 726

Query: 931  SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 990
              YTPL +A   G V ++  LL  GA +N++T  K G +PL  AA  GHT  + +LL  G
Sbjct: 727  LGYTPLIVACHYGNVKMVNFLLKQGANVNAKT--KNGYTPLHQAAQQGHTHIINVLLQHG 784

Query: 991  SDINAQIETNRNTALTLACFQGRTEVVSLL 1020
            +  NA    N NTAL +A   G   VV  L
Sbjct: 785  AKPNA-TTANGNTALAIAKRLGYISVVDTL 813



 Score =  283 bits (724), Expect = 1e-75
 Identities = 244/808 (30%), Positives = 377/808 (46%), Gaps = 37/808 (4%)

Query: 330  QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389
            + S  N +   A   G +D V   L+ G  I   N+NG   L  A   GHV + + LL  
Sbjct: 27   KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 390  GAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 449
            G+ +++ + +   +AL +A   G  E+V+ L++ GA+   ++    T L  A  + H++V
Sbjct: 87   GSSVDSATKK-GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 145

Query: 450  ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLME-AA 508
             + LL++GA  +   +   +PL +A   GH +  A+L+E      +   +   P +  AA
Sbjct: 146  VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAA 200

Query: 509  REGHEEMVALLLGQGANINAQ-------TEETQETALTLACCGGFLEVADFLIKAGADIE 561
            R+   +  ALLL    N + Q       T E+  T L +A   G + VA  L+  GA ++
Sbjct: 201  RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260

Query: 562  LGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
                   TPL  A++ G+  +VK LL  G  + A T  G T L  A  +GH  V ++LL+
Sbjct: 261  FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320

Query: 619  AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLA 678
             GA L   ++ G +PL  AA+  HV  V+ L+   A V+  T +   T L +A   GH  
Sbjct: 321  RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYR 379

Query: 679  VVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPS 738
            V +LLL   A+P  R  +G T L  A K     V+  L+ Y  ++ +     +T    P 
Sbjct: 380  VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLT----PI 435

Query: 739  HDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASI 798
            H       + +  L ++     PD    N+     +   A +G+   +     +      
Sbjct: 436  HVAAFMGHLNI-VLLLLQNGASPD--VTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 492

Query: 799  SQPQTPTPSPIISPSAMLPIYPAI-----DIDAQTESNHDTALTLACAGGHEELVQTLLE 853
               +  TP  I S      I   +       DA T +N  T L ++   G  ++   LLE
Sbjct: 493  RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISAREGQVDVASVLLE 551

Query: 854  RGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQE 913
             GA+     KKGFTPL +AA  G + V ++LL   A  ++  +    TPL +A     Q+
Sbjct: 552  AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQK 610

Query: 914  VVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML 973
            V  LLL +GA+      + YTPL +AA    + I   LLN GAE N  T  K G++PL L
Sbjct: 611  VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT--KQGVTPLHL 668

Query: 974  AAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKT 1033
            A+  GHT  V LLLD G++I+   ++   T+L LA  + +  V  +L    A+ +   K 
Sbjct: 669  ASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKVNVADILTKHGADQDAHTKL 727

Query: 1034 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1093
            G TPL+ A   G  ++   LL +GA+VNA     +  T L  AA +GH     +L+  GA
Sbjct: 728  GYTPLIVACHYGNVKMVNFLLKQGANVNAK--TKNGYTPLHQAAQQGHTHIINVLLQHGA 785

Query: 1094 HIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
              +     GNT L +A   G++ VV  L
Sbjct: 786  KPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  282 bits (722), Expect = 2e-75
 Identities = 258/810 (31%), Positives = 373/810 (46%), Gaps = 87/810 (10%)

Query: 232 QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 291
           Q+   +L  A  EG V  V++LL  G SV+  T++G + L +A  AG  E+ +VL+   A
Sbjct: 62  QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA 121

Query: 292 NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351
           N+  +   G  TPL  AA   H+ +VK LL + A+ +  +  G T L  A   G+   V 
Sbjct: 122 NINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180

Query: 352 VLLESGAS------------------------IEDHN-------------ENGHTPLMEA 374
           +LLE+                             DHN             E+G TPL  A
Sbjct: 181 ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240

Query: 375 GSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDE 433
              G+V VA LLL  GA ++ T  N    + L +A  +G+  MV+ LL+ G   + KT +
Sbjct: 241 AHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298

Query: 434 MHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASL 493
             T L  A   GH +V  LLL+ GA +     +  SPL +AA G HVE    L++  A +
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 358

Query: 494 EEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFL 553
           ++V  +  T L  AA  GH  +  LLL + AN NA+      T L +AC    ++V + L
Sbjct: 359 DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKVMELL 417

Query: 554 IKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHT 610
           +K GA I+       TP+  AA  GHL +V  LL  GA+   T   G+TAL  A   G  
Sbjct: 418 VKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQV 477

Query: 611 DVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSL 670
           +V   LL+ GA ++  +   +TPL  A+R G    VQ L+   A+ +  T N  +T L +
Sbjct: 478 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG-YTPLHI 536

Query: 671 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPD 730
           +   G + V  +LL  GA  +   K G T L  AAK G   V   LL       SA    
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596

Query: 731 VTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSN-T 789
           +T L   +H  N+                            L +  K  S  A+A +  T
Sbjct: 597 LTPLHVAAHYDNQ-------------------------KVALLLLEKGASPHATAKNGYT 631

Query: 790 PTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQ 849
           P H IAA  +Q Q    S +++  A   I     +         T L LA   GH ++V 
Sbjct: 632 PLH-IAAKKNQMQ--IASTLLNYGAETNIVTKQGV---------TPLHLASQEGHTDMVT 679

Query: 850 TLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSG 909
            LL++GA+I    K G T L LAA    V V +IL  +GAD +A + +   TPL +AC  
Sbjct: 680 LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT-KLGYTPLIVACHY 738

Query: 910 GRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS 969
           G  ++V  LL +GAN   +  + YTPL  AA  G+ +II +LL  GA+ N+ T +  G +
Sbjct: 739 GNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTAN--GNT 796

Query: 970 PLMLAAMNGHTAAVKLLLDMGSDINAQIET 999
            L +A   G+ + V  L  +  ++     T
Sbjct: 797 ALAIAKRLGYISVVDTLKVVTEEVTTTTTT 826



 Score =  280 bits (716), Expect = 1e-74
 Identities = 279/976 (28%), Positives = 442/976 (45%), Gaps = 76/976 (7%)

Query: 408  ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
            A   G+L+ V   L+ G D          AL  A  +GHV + + LL  G+ V+      
Sbjct: 38   AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 468  ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
             + L +A+  G  E+  +L++ GA++   +  G+TPL  AA+E H ++V  LL  GAN +
Sbjct: 98   NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 528  AQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLME-AAQEGHLELVKYLLAA 586
              TE+   T L +A   G  +    L++   D +     P +  AA++   +    LL  
Sbjct: 158  TATEDGF-TPLAVALQQGHNQAVAILLEN--DTKGKVRLPALHIAARKDDTKSAALLLQN 214

Query: 587  GAN--------VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 638
              N        V+ TT +G T L  A   G+ +VA +LL  GA ++  +  G TPL  A+
Sbjct: 215  DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274

Query: 639  RAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGS 698
            + G+   V+ L+ +G  ++  T +   T L  A   GH  VVELLL  GA    R K+G 
Sbjct: 275  KRGNTNMVKLLLDRGGQIDAKTRDG-LTPLHCAARSGHDQVVELLLERGAPLLARTKNGL 333

Query: 699  TMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPP 758
            + L  AA+G H   V +LL +      AP  DVT       D   A  V           
Sbjct: 334  SPLHMAAQGDHVECVKHLLQH-----KAPVDDVTL------DYLTALHVAAHC------- 375

Query: 759  QEPDKPPANVATTLPIRNKAVSGRASAMSN-TPTHSIAASISQPQTPTPSPIISPSAMLP 817
                    +   T  + +K  +  A A++  TP H IA   ++         I    +L 
Sbjct: 376  -------GHYRVTKLLLDKRANPNARALNGFTPLH-IACKKNR---------IKVMELLV 418

Query: 818  IYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH 877
             Y A  I A TES   T + +A   GH  +V  LL+ GAS +  + +G T L +AA AG 
Sbjct: 419  KYGA-SIQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 476

Query: 878  VGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLS 937
            V VV  LL NGA ++A++ R + TPL +A   G+ E+V+LLL   A+ +    + YTPL 
Sbjct: 477  VEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535

Query: 938  LAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI 997
            ++A  G V++  +LL AGA  +  T  K G +PL +AA  G     KLLL   +  ++  
Sbjct: 536  ISAREGQVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 593

Query: 998  ETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG 1057
            + N  T L +A      +V  LLL++ A+    AK G TPL  AA     ++   LL+ G
Sbjct: 594  K-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYG 652

Query: 1058 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDV 1117
            A+ N   V     T L +A+ +GH     LL+ +GA+I +  K G T L LAA    ++V
Sbjct: 653  AETNI--VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710

Query: 1118 VQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDK 1177
              +L + GAD DA      TPL+ A   G+VK+V +L+K+      +++       +   
Sbjct: 711  ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV--NAKTKNGYTPLHQA 768

Query: 1178 EMLKKCHLCMESIVQAKDRQAAEANKNASILLEE-------LDLEKLREESRRLALAAKR 1230
                  H+    +       A  AN N ++ + +       +D  K+  E          
Sbjct: 769  AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT 828

Query: 1231 EKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTT 1290
            EK       K        E ++  ++E  +       E L+ ED  E L +    ++   
Sbjct: 829  EKH------KLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKE-LGDDSLPSSQFL 881

Query: 1291 IGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNG 1350
             G++    +L G    R++++ + SS R +  +  +      + DD + I   Q   +  
Sbjct: 882  DGMNYLRYSLEGG---RSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAK 938

Query: 1351 ESKSSSTSESGDSDNM 1366
            E++ +S   S  ++N+
Sbjct: 939  EAERNSYRLSWGTENL 954



 Score =  199 bits (506), Expect = 3e-50
 Identities = 160/483 (33%), Positives = 241/483 (49%), Gaps = 16/483 (3%)

Query: 193 KAFADPEVLRRLTS---SVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA 249
           KA  D   L  LT+   +  C        L   RA   A A  +    L  AC +  +  
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413

Query: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309
           +  L+  G S+   TE G + + +A   G+  +  +LL   A+ +   I+G+ T L  AA
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAA 472

Query: 310 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT 369
             G V++V+ LL + A V+A++    T L  A   G  ++V++LL+  A  +    NG+T
Sbjct: 473 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 532

Query: 370 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKE--SALTLACYKGHLEMVRFLLEAGADQ 427
           PL  +   G V+VA +LLE GA    HS   K+  + L +A   G L++ + LL+  A  
Sbjct: 533 PLHISAREGQVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589

Query: 428 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 487
           +       T L  A    + +VA LLL+ GA  +  A +  +PL +AA    +++A+ L+
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649

Query: 488 ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
             GA    V  +G TPL  A++EGH +MV LLL +GANI+  T+    T+L LA     +
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKV 708

Query: 548 EVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604
            VAD L K GAD +       TPL+ A   G++++V +LL  GANV+A T  G T L  A
Sbjct: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768

Query: 605 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL--ISKGANVNRTTAN 662
            + GHT + +VLLQ GA     +  G T L  A R G++  V  L  +++      TT  
Sbjct: 769 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT 828

Query: 663 NDH 665
             H
Sbjct: 829 EKH 831



 Score =  163 bits (412), Expect = 2e-39
 Identities = 112/354 (31%), Positives = 193/354 (54%), Gaps = 20/354 (5%)

Query: 829  ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 888
            +S+ + +   A   G+ + V   L+ G  I   ++ G   L LAA  GHVG+V+ LL  G
Sbjct: 28   KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87

Query: 889  ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 948
            + +++ +++  +T L +A   G+ EVV++L+  GAN   ++ + +TPL +AA   +++++
Sbjct: 88   SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 949  KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1008
            K LL  GA  N  T ++ G +PL +A   GH  AV +LL+  +D   ++   R  AL +A
Sbjct: 147  KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 199

Query: 1009 CFQGRTEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1060
              +  T+  +LLL    N + ++K        +G TPL  AA  G   V  +LL++GA V
Sbjct: 200  ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259

Query: 1061 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120
            +      +  T L +A+ +G+    +LL+ RG  ID + + G TPL  AA  GH  VV+L
Sbjct: 260  DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317

Query: 1121 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATI 1174
            L++ GA + A     ++PL  A +  HV+ V++L++  ++ P D   + Y+  +
Sbjct: 318  LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 369



 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 53/180 (29%), Positives = 92/180 (51%), Gaps = 10/180 (5%)

Query: 1039 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1098
            + AA  G  +     L  G D+N      +   AL +AA +GH    + L+GRG+ +D  
Sbjct: 36   LRAARAGNLDKVVEYLKGGIDINT--CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 1099 NKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE- 1157
             KKGNT L +A+  G  +VV++LV+ GA+++A      TPL  A ++ H+ VV+YL++  
Sbjct: 94   TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153

Query: 1158 VNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAA-------EANKNASILLE 1210
             NQ  +  +    +A    +   +   + +E+  + K R  A       +  K+A++LL+
Sbjct: 154  ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 36/95 (37%), Positives = 49/95 (51%), Gaps = 2/95 (2%)

Query: 1064 PVPSSRDTALTIAADKGHY-KFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1122
            P  S  + +   AA  G+  K  E L G G  I+  N+ G   L LAA  GH+ +VQ L+
Sbjct: 26   PKKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELL 84

Query: 1123 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
              G+ VD+A  +  T L  A   G  +VV+ LVKE
Sbjct: 85   GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  308 bits (788), Expect = 5e-83
 Identities = 259/810 (31%), Positives = 386/810 (47%), Gaps = 52/810 (6%)

Query: 235  NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 294
            N S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+
Sbjct: 32   NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91

Query: 295  DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354
                KG+ T L  A+  G  ++VK+L+   A++NAQS  G T L  A    ++DVVK LL
Sbjct: 92   SATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150

Query: 355  ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414
            E+GA+     E+G TPL  A   GH +   +LLEN         + +  AL +A  K   
Sbjct: 151  ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT-----KGKVRLPALHIAARKDDT 205

Query: 415  EMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466
            +    LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +
Sbjct: 206  KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265

Query: 467  FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526
              +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA +
Sbjct: 266  GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325

Query: 527  NAQTEETQETALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYL 583
             A+T+    + L +A  G  +E    L++  A   D+ L   T L  AA  GH  + K L
Sbjct: 326  LARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384

Query: 584  LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHV 643
            L   AN +A    G T L  AC+     V ++L++ GA ++  +E G TP+  AA  GH+
Sbjct: 385  LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444

Query: 644  CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703
              V  L+  GA+ + T    + T L +A   G + VV  LL +GA    R ++  T L  
Sbjct: 445  NIVLLLLQNGASPDVTNIRGE-TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503

Query: 704  AAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPM--------- 754
            A++ G T +V  LL +    ++ P    T    P H   R  +V V ++ +         
Sbjct: 504  ASRLGKTEIVQLLLQH----MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 559

Query: 755  ----VVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPII 810
                  P     K  +     L ++ +A +  A     TP H +AA     +        
Sbjct: 560  TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH-VAAHYDNQKV------- 611

Query: 811  SPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLI 870
               A+L +       A T  N  T L +A      ++  TLL  GA      K+G TPL 
Sbjct: 612  ---ALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 667

Query: 871  LAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930
            LA+  GH  +V +LLD GA+I   S ++  T L LA    +  V ++L   GA+++    
Sbjct: 668  LASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 726

Query: 931  SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 990
              YTPL +A   G V ++  LL  GA +N++T  K G +PL  AA  GHT  + +LL  G
Sbjct: 727  LGYTPLIVACHYGNVKMVNFLLKQGANVNAKT--KNGYTPLHQAAQQGHTHIINVLLQHG 784

Query: 991  SDINAQIETNRNTALTLACFQGRTEVVSLL 1020
            +  NA    N NTAL +A   G   VV  L
Sbjct: 785  AKPNA-TTANGNTALAIAKRLGYISVVDTL 813



 Score =  283 bits (724), Expect = 1e-75
 Identities = 244/808 (30%), Positives = 377/808 (46%), Gaps = 37/808 (4%)

Query: 330  QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389
            + S  N +   A   G +D V   L+ G  I   N+NG   L  A   GHV + + LL  
Sbjct: 27   KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 390  GAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 449
            G+ +++ + +   +AL +A   G  E+V+ L++ GA+   ++    T L  A  + H++V
Sbjct: 87   GSSVDSATKK-GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 145

Query: 450  ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLME-AA 508
             + LL++GA  +   +   +PL +A   GH +  A+L+E      +   +   P +  AA
Sbjct: 146  VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAA 200

Query: 509  REGHEEMVALLLGQGANINAQ-------TEETQETALTLACCGGFLEVADFLIKAGADIE 561
            R+   +  ALLL    N + Q       T E+  T L +A   G + VA  L+  GA ++
Sbjct: 201  RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260

Query: 562  LGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
                   TPL  A++ G+  +VK LL  G  + A T  G T L  A  +GH  V ++LL+
Sbjct: 261  FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320

Query: 619  AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLA 678
             GA L   ++ G +PL  AA+  HV  V+ L+   A V+  T +   T L +A   GH  
Sbjct: 321  RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYR 379

Query: 679  VVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPS 738
            V +LLL   A+P  R  +G T L  A K     V+  L+ Y  ++ +     +T    P 
Sbjct: 380  VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLT----PI 435

Query: 739  HDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASI 798
            H       + +  L ++     PD    N+     +   A +G+   +     +      
Sbjct: 436  HVAAFMGHLNI-VLLLLQNGASPD--VTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 492

Query: 799  SQPQTPTPSPIISPSAMLPIYPAI-----DIDAQTESNHDTALTLACAGGHEELVQTLLE 853
               +  TP  I S      I   +       DA T +N  T L ++   G  ++   LLE
Sbjct: 493  RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISAREGQVDVASVLLE 551

Query: 854  RGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQE 913
             GA+     KKGFTPL +AA  G + V ++LL   A  ++  +    TPL +A     Q+
Sbjct: 552  AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQK 610

Query: 914  VVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML 973
            V  LLL +GA+      + YTPL +AA    + I   LLN GAE N  T  K G++PL L
Sbjct: 611  VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT--KQGVTPLHL 668

Query: 974  AAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKT 1033
            A+  GHT  V LLLD G++I+   ++   T+L LA  + +  V  +L    A+ +   K 
Sbjct: 669  ASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKVNVADILTKHGADQDAHTKL 727

Query: 1034 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1093
            G TPL+ A   G  ++   LL +GA+VNA     +  T L  AA +GH     +L+  GA
Sbjct: 728  GYTPLIVACHYGNVKMVNFLLKQGANVNAK--TKNGYTPLHQAAQQGHTHIINVLLQHGA 785

Query: 1094 HIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
              +     GNT L +A   G++ VV  L
Sbjct: 786  KPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  282 bits (722), Expect = 2e-75
 Identities = 258/810 (31%), Positives = 373/810 (46%), Gaps = 87/810 (10%)

Query: 232 QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 291
           Q+   +L  A  EG V  V++LL  G SV+  T++G + L +A  AG  E+ +VL+   A
Sbjct: 62  QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA 121

Query: 292 NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351
           N+  +   G  TPL  AA   H+ +VK LL + A+ +  +  G T L  A   G+   V 
Sbjct: 122 NINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180

Query: 352 VLLESGAS------------------------IEDHN-------------ENGHTPLMEA 374
           +LLE+                             DHN             E+G TPL  A
Sbjct: 181 ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240

Query: 375 GSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDE 433
              G+V VA LLL  GA ++ T  N    + L +A  +G+  MV+ LL+ G   + KT +
Sbjct: 241 AHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298

Query: 434 MHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASL 493
             T L  A   GH +V  LLL+ GA +     +  SPL +AA G HVE    L++  A +
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 358

Query: 494 EEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFL 553
           ++V  +  T L  AA  GH  +  LLL + AN NA+      T L +AC    ++V + L
Sbjct: 359 DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKVMELL 417

Query: 554 IKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHT 610
           +K GA I+       TP+  AA  GHL +V  LL  GA+   T   G+TAL  A   G  
Sbjct: 418 VKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQV 477

Query: 611 DVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSL 670
           +V   LL+ GA ++  +   +TPL  A+R G    VQ L+   A+ +  T N  +T L +
Sbjct: 478 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG-YTPLHI 536

Query: 671 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPD 730
           +   G + V  +LL  GA  +   K G T L  AAK G   V   LL       SA    
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596

Query: 731 VTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSN-T 789
           +T L   +H  N+                            L +  K  S  A+A +  T
Sbjct: 597 LTPLHVAAHYDNQ-------------------------KVALLLLEKGASPHATAKNGYT 631

Query: 790 PTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQ 849
           P H IAA  +Q Q    S +++  A   I     +         T L LA   GH ++V 
Sbjct: 632 PLH-IAAKKNQMQ--IASTLLNYGAETNIVTKQGV---------TPLHLASQEGHTDMVT 679

Query: 850 TLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSG 909
            LL++GA+I    K G T L LAA    V V +IL  +GAD +A + +   TPL +AC  
Sbjct: 680 LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT-KLGYTPLIVACHY 738

Query: 910 GRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS 969
           G  ++V  LL +GAN   +  + YTPL  AA  G+ +II +LL  GA+ N+ T +  G +
Sbjct: 739 GNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTAN--GNT 796

Query: 970 PLMLAAMNGHTAAVKLLLDMGSDINAQIET 999
            L +A   G+ + V  L  +  ++     T
Sbjct: 797 ALAIAKRLGYISVVDTLKVVTEEVTTTTTT 826



 Score =  280 bits (716), Expect = 1e-74
 Identities = 279/976 (28%), Positives = 442/976 (45%), Gaps = 76/976 (7%)

Query: 408  ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
            A   G+L+ V   L+ G D          AL  A  +GHV + + LL  G+ V+      
Sbjct: 38   AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 468  ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
             + L +A+  G  E+  +L++ GA++   +  G+TPL  AA+E H ++V  LL  GAN +
Sbjct: 98   NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 528  AQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLME-AAQEGHLELVKYLLAA 586
              TE+   T L +A   G  +    L++   D +     P +  AA++   +    LL  
Sbjct: 158  TATEDGF-TPLAVALQQGHNQAVAILLEN--DTKGKVRLPALHIAARKDDTKSAALLLQN 214

Query: 587  GAN--------VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 638
              N        V+ TT +G T L  A   G+ +VA +LL  GA ++  +  G TPL  A+
Sbjct: 215  DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274

Query: 639  RAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGS 698
            + G+   V+ L+ +G  ++  T +   T L  A   GH  VVELLL  GA    R K+G 
Sbjct: 275  KRGNTNMVKLLLDRGGQIDAKTRDG-LTPLHCAARSGHDQVVELLLERGAPLLARTKNGL 333

Query: 699  TMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPP 758
            + L  AA+G H   V +LL +      AP  DVT       D   A  V           
Sbjct: 334  SPLHMAAQGDHVECVKHLLQH-----KAPVDDVTL------DYLTALHVAAHC------- 375

Query: 759  QEPDKPPANVATTLPIRNKAVSGRASAMSN-TPTHSIAASISQPQTPTPSPIISPSAMLP 817
                    +   T  + +K  +  A A++  TP H IA   ++         I    +L 
Sbjct: 376  -------GHYRVTKLLLDKRANPNARALNGFTPLH-IACKKNR---------IKVMELLV 418

Query: 818  IYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH 877
             Y A  I A TES   T + +A   GH  +V  LL+ GAS +  + +G T L +AA AG 
Sbjct: 419  KYGA-SIQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 476

Query: 878  VGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLS 937
            V VV  LL NGA ++A++ R + TPL +A   G+ E+V+LLL   A+ +    + YTPL 
Sbjct: 477  VEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535

Query: 938  LAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI 997
            ++A  G V++  +LL AGA  +  T  K G +PL +AA  G     KLLL   +  ++  
Sbjct: 536  ISAREGQVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 593

Query: 998  ETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG 1057
            + N  T L +A      +V  LLL++ A+    AK G TPL  AA     ++   LL+ G
Sbjct: 594  K-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYG 652

Query: 1058 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDV 1117
            A+ N   V     T L +A+ +GH     LL+ +GA+I +  K G T L LAA    ++V
Sbjct: 653  AETNI--VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710

Query: 1118 VQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDK 1177
              +L + GAD DA      TPL+ A   G+VK+V +L+K+      +++       +   
Sbjct: 711  ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV--NAKTKNGYTPLHQA 768

Query: 1178 EMLKKCHLCMESIVQAKDRQAAEANKNASILLEE-------LDLEKLREESRRLALAAKR 1230
                  H+    +       A  AN N ++ + +       +D  K+  E          
Sbjct: 769  AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT 828

Query: 1231 EKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTT 1290
            EK       K        E ++  ++E  +       E L+ ED  E L +    ++   
Sbjct: 829  EKH------KLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKE-LGDDSLPSSQFL 881

Query: 1291 IGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNG 1350
             G++    +L G    R++++ + SS R +  +  +      + DD + I   Q   +  
Sbjct: 882  DGMNYLRYSLEGG---RSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAK 938

Query: 1351 ESKSSSTSESGDSDNM 1366
            E++ +S   S  ++N+
Sbjct: 939  EAERNSYRLSWGTENL 954



 Score =  199 bits (506), Expect = 3e-50
 Identities = 160/483 (33%), Positives = 241/483 (49%), Gaps = 16/483 (3%)

Query: 193 KAFADPEVLRRLTS---SVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA 249
           KA  D   L  LT+   +  C        L   RA   A A  +    L  AC +  +  
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413

Query: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309
           +  L+  G S+   TE G + + +A   G+  +  +LL   A+ +   I+G+ T L  AA
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAA 472

Query: 310 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT 369
             G V++V+ LL + A V+A++    T L  A   G  ++V++LL+  A  +    NG+T
Sbjct: 473 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 532

Query: 370 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKE--SALTLACYKGHLEMVRFLLEAGADQ 427
           PL  +   G V+VA +LLE GA    HS   K+  + L +A   G L++ + LL+  A  
Sbjct: 533 PLHISAREGQVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589

Query: 428 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 487
           +       T L  A    + +VA LLL+ GA  +  A +  +PL +AA    +++A+ L+
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649

Query: 488 ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
             GA    V  +G TPL  A++EGH +MV LLL +GANI+  T+    T+L LA     +
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKV 708

Query: 548 EVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604
            VAD L K GAD +       TPL+ A   G++++V +LL  GANV+A T  G T L  A
Sbjct: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768

Query: 605 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL--ISKGANVNRTTAN 662
            + GHT + +VLLQ GA     +  G T L  A R G++  V  L  +++      TT  
Sbjct: 769 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT 828

Query: 663 NDH 665
             H
Sbjct: 829 EKH 831



 Score =  163 bits (412), Expect = 2e-39
 Identities = 112/354 (31%), Positives = 193/354 (54%), Gaps = 20/354 (5%)

Query: 829  ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 888
            +S+ + +   A   G+ + V   L+ G  I   ++ G   L LAA  GHVG+V+ LL  G
Sbjct: 28   KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87

Query: 889  ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 948
            + +++ +++  +T L +A   G+ EVV++L+  GAN   ++ + +TPL +AA   +++++
Sbjct: 88   SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 949  KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1008
            K LL  GA  N  T ++ G +PL +A   GH  AV +LL+  +D   ++   R  AL +A
Sbjct: 147  KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 199

Query: 1009 CFQGRTEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1060
              +  T+  +LLL    N + ++K        +G TPL  AA  G   V  +LL++GA V
Sbjct: 200  ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259

Query: 1061 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120
            +      +  T L +A+ +G+    +LL+ RG  ID + + G TPL  AA  GH  VV+L
Sbjct: 260  DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317

Query: 1121 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATI 1174
            L++ GA + A     ++PL  A +  HV+ V++L++  ++ P D   + Y+  +
Sbjct: 318  LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 369



 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 53/180 (29%), Positives = 92/180 (51%), Gaps = 10/180 (5%)

Query: 1039 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1098
            + AA  G  +     L  G D+N      +   AL +AA +GH    + L+GRG+ +D  
Sbjct: 36   LRAARAGNLDKVVEYLKGGIDINT--CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 1099 NKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE- 1157
             KKGNT L +A+  G  +VV++LV+ GA+++A      TPL  A ++ H+ VV+YL++  
Sbjct: 94   TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153

Query: 1158 VNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAA-------EANKNASILLE 1210
             NQ  +  +    +A    +   +   + +E+  + K R  A       +  K+A++LL+
Sbjct: 154  ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 36/95 (37%), Positives = 49/95 (51%), Gaps = 2/95 (2%)

Query: 1064 PVPSSRDTALTIAADKGHY-KFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1122
            P  S  + +   AA  G+  K  E L G G  I+  N+ G   L LAA  GH+ +VQ L+
Sbjct: 26   PKKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELL 84

Query: 1123 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
              G+ VD+A  +  T L  A   G  +VV+ LVKE
Sbjct: 85   GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 57/238 (23%), Positives = 97/238 (40%), Gaps = 18/238 (7%)

Query: 1233 RKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIG 1292
            +K  RRK KE+Q++K E ++A + E  EL+    +E L   ++P +  EP      T+  
Sbjct: 1701 KKPVRRKLKEKQKQKEEGLQA-SAEKAELKKGSSEESL--GEDPGLAPEPLPTVKATSPL 1757

Query: 1293 ISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGES 1352
            I     T  GS   +   +       +  ++K+ P  V+   D P   ++ +P      S
Sbjct: 1758 IE---ETPIGSIKDKVKALQKRVEDEQKGRSKL-PIRVKGKEDVPKKTTH-RPHPAASPS 1812

Query: 1353 KSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEE 1412
              S     G       S  ++  S  +SS K++ H P  V+ +  ++K   V  +   E 
Sbjct: 1813 LKSERHAPGSP-----SPKTERHSTLSSSAKTERHPP--VSPSSKTEKHSPVSPSAKTER 1865

Query: 1413 RKSVSGKASIKLSETISEGTS---NSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREE 1467
                S  +  +    +S  T    +S  + TK+   P  SP+GK     P     R E
Sbjct: 1866 HSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTE 1923



 Score = 38.5 bits (88), Expect = 0.079
 Identities = 43/151 (28%), Positives = 59/151 (39%), Gaps = 20/151 (13%)

Query: 1779 PMPTAKEHYPVSSPSSPSPPAQPGGVS----RNSPLDCGSASPN--KVASSSEQEAGSP- 1831
            P  T    +P +SPS  S    PG  S    R+S L   + +     V+ SS+ E  SP 
Sbjct: 1798 PKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPV 1857

Query: 1832 -PVVETTNTRPPNSSS-----SSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMT 1885
             P  +T    P +SSS     S  S S  + +  P  S   E  PP     V P      
Sbjct: 1858 SPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPP-----VSPSGKTDK 1912

Query: 1886 VPPLATSSAPVAVPSTAP--VTYPMPQTPMG 1914
             PP++ S      P  +P      +P +P G
Sbjct: 1913 RPPVSPSGRTEKHPPVSPGRTEKRLPVSPSG 1943



 Score = 35.4 bits (80), Expect = 0.67
 Identities = 45/204 (22%), Positives = 75/204 (36%), Gaps = 33/204 (16%)

Query: 1719 TTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATY 1778
            TT     A++    S   +P SPS + +   T+  +S+A T      + ++ T   +   
Sbjct: 1801 TTHRPHPAASPSLKSERHAPGSPSPKTERHSTL--SSSAKTERHPPVSPSSKTEKHSPVS 1858

Query: 1779 PMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVET-- 1836
            P    + H P SS S            ++SP+   + +      SS +    PPV  +  
Sbjct: 1859 PSAKTERHSPASSSSK---------TEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGK 1909

Query: 1837 TNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPV 1896
            T+ RPP   S SG +  H               PP+   +    E R+ V P   +    
Sbjct: 1910 TDKRPP--VSPSGRTEKH---------------PPVSPGRT---EKRLPVSPSGRTDKHQ 1949

Query: 1897 AVPSTAPVTYPMPQTPMGCPQPTP 1920
             V +       +P +P G  +  P
Sbjct: 1950 PVSTAGKTEKHLPVSPSGKTEKQP 1973


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  303 bits (775), Expect = 2e-81
 Identities = 259/844 (30%), Positives = 397/844 (47%), Gaps = 47/844 (5%)

Query: 372  MEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKT 431
            + A  AGH+E A   ++NG  IN   N+   +AL LA  +GH+E+V  LL+  A+ +  T
Sbjct: 46   LRAARAGHLEKALDYIKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAAT 104

Query: 432  DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491
             + +TAL  A + G  EV ++L+ +GA VN  + +  +PL +AA   H+E+   L++ GA
Sbjct: 105  KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164

Query: 492  SLEEVNDEGYTPLMEAAREGHEEMVALLLGQ---------GANINAQTEETQETALTLAC 542
            S     ++G+TPL  A ++GH+++V+LLL             +I A+ ++T+  AL L  
Sbjct: 165  SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN 224

Query: 543  CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
                   AD   K+G        TPL  AA  G++ +   LL   A V  T     T L 
Sbjct: 225  DNN----ADVESKSG-------FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH 273

Query: 603  YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662
             A + G+ ++  +LL  GA ++ ++  G TPL   AR+GH   V+ L+ + A +   T  
Sbjct: 274  VASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT-K 332

Query: 663  NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722
            N  + L +A  G HL  V+LLL H         D  T L  AA  GH  V   LLD   N
Sbjct: 333  NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392

Query: 723  LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGR 782
                P         P H   +  R+ V  L +              +   PI   A  G 
Sbjct: 393  ----PNAKALNGFTPLHIACKKNRIKVMELLL---KHGASIQAVTESGLTPIHVAAFMGH 445

Query: 783  ASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDID-AQTES---NHDTALTL 838
             + +S    H  + + +  +  T   + + S    +   +  D AQ E+   +  T L +
Sbjct: 446  VNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHI 505

Query: 839  ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 898
            +   G  ++VQ LL++GAS       G+TPL L+A  GH  V   LLD+GA +   +++ 
Sbjct: 506  SARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKK- 564

Query: 899  KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 958
              TPL +A   G+ EV  LLL + A+ +    S  TPL +AA      +  +LL+ GA  
Sbjct: 565  GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGA-- 622

Query: 959  NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS 1018
            +    +K G +PL +AA          LL+ G+D NA +      ++ LA  +G  ++VS
Sbjct: 623  SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA-VTRQGIASVHLAAQEGHVDMVS 681

Query: 1019 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1078
            LLL R ANV    K+GLTPL  AA      V  VL+++GA V+A        T L +   
Sbjct: 682  LLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQ--TKMGYTPLHVGCH 739

Query: 1079 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP 1138
             G+ K    L+   A ++ + K G TPL  AA  GH  ++ +L+Q  A  +       T 
Sbjct: 740  YGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTA 799

Query: 1139 LMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQA 1198
            L  A R G++ VV  L K V +     E M    T+T+K  +      M  ++   D + 
Sbjct: 800  LGIARRLGYISVVDTL-KIVTE-----ETMT-TTTVTEKHKMNVPE-TMNEVLDMSDDEV 851

Query: 1199 AEAN 1202
             +AN
Sbjct: 852  RKAN 855



 Score =  288 bits (738), Expect = 3e-77
 Identities = 258/832 (31%), Positives = 391/832 (46%), Gaps = 48/832 (5%)

Query: 235  NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 294
            NR L E  +E +    RK     R   + ++   S L  A  AG+ E A   +    ++ 
Sbjct: 11   NRDL-EINAEEEPEKKRKHRKRSRDRKKKSDANASYL-RAARAGHLEKALDYIKNGVDIN 68

Query: 295  DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354
                 G +  L  A+  GHV++V  LL  +A+V+A +  GNTAL  A   G  +VVKVL+
Sbjct: 69   ICNQNG-LNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLV 127

Query: 355  ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414
             +GA++   ++NG TPL  A    H+EV + LL+NGA   + + E   + L +A  +GH 
Sbjct: 128  TNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLAVALQQGHD 186

Query: 415  EMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 474
            ++V  LLE     + +   +H A  +       + A LLL +    ++ + S  +PL +A
Sbjct: 187  QVVSLLLENDTKGKVRLPALHIAARK----DDTKAAALLLQNDNNADVESKSGFTPLHIA 242

Query: 475  ACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQ 534
            A  G++ +A LL+ R A+++       TPL  A++ G+  MV LLL +GA I+A+T +  
Sbjct: 243  AHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD-- 300

Query: 535  ETALTLACCG---GFLEVADFLIKAGADI----ELGCSTPLMEAAQEGHLELVKYLLAAG 587
               LT   CG   G  +V + L+   A I    + G S PL  A Q  HL  V+ LL   
Sbjct: 301  --GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS-PLHMATQGDHLNCVQLLLQHN 357

Query: 588  ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQ 647
              V   T    TAL  A   GH  VA VLL   A+   ++  G TPL  A +   +  ++
Sbjct: 358  VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVME 417

Query: 648  FLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 707
             L+  GA++   T  +  T + +A   GH+ +V  L+ HGA P      G T L  AA+ 
Sbjct: 418  LLLKHGASIQAVT-ESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARS 476

Query: 708  GHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPV--QALPMVVPPQEPDKPP 765
            G   VV YL+     + +    D T    P H   R  +  +  Q L     P       
Sbjct: 477  GQAEVVRYLVQDGAQVEAKAKDDQT----PLHISARLGKADIVQQLLQQGASP------- 525

Query: 766  ANVATT---LPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIIS-----PSAMLP 817
             N ATT    P+   A  G     +    H  + SI+  +  TP  + +       A L 
Sbjct: 526  -NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL 584

Query: 818  IYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH 877
            +  +   DA  +S   T L +A    ++++   LL++GAS     K G+TPL +AA    
Sbjct: 585  LQKSASPDAAGKSGL-TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQ 643

Query: 878  VGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLS 937
            + +   LL+ GAD  A + R     + LA   G  ++V LLL R AN    N S  TPL 
Sbjct: 644  MDIATTLLEYGADANAVT-RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLH 702

Query: 938  LAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI 997
            LAA    VN+ ++L+N GA ++++T  K+G +PL +    G+   V  LL   + +NA+ 
Sbjct: 703  LAAQEDRVNVAEVLVNQGAHVDAQT--KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT 760

Query: 998  ETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1049
            + N  T L  A  QG T ++++LL   A+       G T L  A   GY  V
Sbjct: 761  K-NGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISV 811



 Score =  280 bits (716), Expect = 1e-74
 Identities = 259/843 (30%), Positives = 388/843 (46%), Gaps = 91/843 (10%)

Query: 232  QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 291
            Q+   +L  A  EG V  V +LL    +V+  T++G + L +A  AG  E+ +VL+   A
Sbjct: 72   QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGA 131

Query: 292  NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351
            NV  +   G  TPL  AA   H+++VK LL + A  +  +  G T L  A   G+  VV 
Sbjct: 132  NVNAQSQNG-FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190

Query: 352  VLLES---------------------GASIEDHNEN--------GHTPLMEAGSAGHVEV 382
            +LLE+                      A++   N+N        G TPL  A   G++ V
Sbjct: 191  LLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINV 250

Query: 383  ARLLLENGAGIN-THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEA 441
            A LLL   A ++ T  N+   + L +A  +G+  MV+ LL+ GA  + KT +  T L   
Sbjct: 251  ATLLLNRAAAVDFTARNDI--TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG 308

Query: 442  CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGY 501
               GH +V  +LLD  A +     +  SPL +A  G H+    LL++    +++V ++  
Sbjct: 309  ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL 368

Query: 502  TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561
            T L  AA  GH ++  +LL + AN NA+      T L +AC    ++V + L+K GA I+
Sbjct: 369  TALHVAAHCGHYKVAKVLLDKKANPNAKA-LNGFTPLHIACKKNRIKVMELLLKHGASIQ 427

Query: 562  LGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
                   TP+  AA  GH+ +V  L+  GA+ + T   G+TAL  A  +G  +V   L+Q
Sbjct: 428  AVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQ 487

Query: 619  AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLA 678
             GA +E +++  +TPL  +AR G    VQ L+ +GA+ N  T +  +T L L+   GH  
Sbjct: 488  DGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG-YTPLHLSAREGHED 546

Query: 679  VVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPS 738
            V   LL HGA  +   K G T L  AAK G   V   LL    +  +A    +T L   +
Sbjct: 547  VAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAA 606

Query: 739  HDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSN-TPTHSIAAS 797
            H  N+                            L + ++  S  A+A +  TP H IAA 
Sbjct: 607  HYDNQ-------------------------KVALLLLDQGASPHAAAKNGYTPLH-IAAK 640

Query: 798  ISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGAS 857
             +Q    T          L  Y A D +A T      ++ LA   GH ++V  LL R A+
Sbjct: 641  KNQMDIAT---------TLLEYGA-DANAVTRQG-IASVHLAAQEGHVDMVSLLLGRNAN 689

Query: 858  IEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVEL 917
            +   +K G TPL LAA    V V E+L++ GA ++AQ+ +   TPL + C  G  ++V  
Sbjct: 690  VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT-KMGYTPLHVGCHYGNIKIVNF 748

Query: 918  LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 977
            LL   A    +  + YTPL  AA  G+ +II +LL   A  N  T +  G + L +A   
Sbjct: 749  LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVN--GNTALGIARRL 806

Query: 978  GHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLD------RKANVEHRA 1031
            G+ + V  L  +        ET   T +T        E ++ +LD      RKAN     
Sbjct: 807  GYISVVDTLKIVTE------ETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEML 860

Query: 1032 KTG 1034
              G
Sbjct: 861  SDG 863



 Score = 40.8 bits (94), Expect = 0.016
 Identities = 110/508 (21%), Positives = 193/508 (37%), Gaps = 76/508 (14%)

Query: 1697 RHSNQNSSGSQVNSAGSLTSSPTTTTSSSA-STVPGTSTNGSPSSPSVRRQLFVTVVKTS 1755
            R+S     G    S G+  S PTT +     ST P  S   +P          +TV   +
Sbjct: 1468 RYSYLTEPGMIERSTGATRSLPTTYSYKPFFSTRPYQSWTTAP----------ITVPGPA 1517

Query: 1756 NATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSA 1815
             +  T++++++SN            P+A     + S S+PSP     G S  S +   S 
Sbjct: 1518 KSGFTSLSSSSSNT-----------PSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISD 1566

Query: 1816 SPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQS 1875
              + + S       S P+    +  P N   SSG+ +      + P      P   L  +
Sbjct: 1567 VASPIRSFRTM---SSPIKTVVSQSPYNIQVSSGTLA------RAPAVTEATPLKGLASN 1617

Query: 1876 QVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTT 1935
                          ++ ++PV    +      +  TP   P+    M + ++      T+
Sbjct: 1618 ST-----------FSSRTSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITS 1666

Query: 1936 A------PHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSACQNSVHPANKP 1989
            A      P K+  S   S+V V+S   I    S+ S V+     +  +    S+ P   P
Sbjct: 1667 AAPLISSPLKSVVSPVKSAVDVISSAKITMASSLSSPVKQMPGHAEVALVNGSISPLKYP 1726

Query: 1990 IAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQS 2049
                 S+ L  G  +T       S+      SVVS+ +     +   ++ +P S PL +S
Sbjct: 1727 ----SSSTLINGCKATATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFS-PL-RS 1780

Query: 2050 DTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYG-----PG 2104
              S AP     L+ P+ S +   ++ S   + T S T      S+I    +Y      P 
Sbjct: 1781 YVSAAPSAFQSLRTPSAS-ALYTSLGSSISATTSSVT------SSIITVPVYSVVNVLPE 1833

Query: 2105 APLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSP-----APSSVPLG 2159
              L   P + +F +   S  +LL+P  + + ++  Q   S   +P       APS++ L 
Sbjct: 1834 PALKKLPDSNSFTK---SAAALLSPIKTLTTETHPQPHFSRTSSPVKSSLFLAPSALKLS 1890

Query: 2160 SEKPSNVSQDRKVPVPIGTERSARIRQT 2187
            +  PS++S  +++   +   +   +R T
Sbjct: 1891 T--PSSLSSSQEILKDVAEMKEDLMRMT 1916



 Score = 36.2 bits (82), Expect = 0.39
 Identities = 49/229 (21%), Positives = 75/229 (32%), Gaps = 36/229 (15%)

Query: 1683 PARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSA---STVP--------- 1730
            P +AT SPK    P H + N+  S++        +   TTSS     S +P         
Sbjct: 3866 PIKAT-SPKDTFPPNHMS-NTKASKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHRDNI 3923

Query: 1731 -------GTSTNGSPSSPSVR----------RQLFVTVVKTSNATTTTVTTTASNNNTAP 1773
                    T   G P     +          R   VT   T+  TTTT TTT + + T  
Sbjct: 3924 IAVRKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVTTTTTTATTTTTTTTTTTTSCTVK 3983

Query: 1774 TNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSR-----NSPLDCGSASPNKVASSSEQEA 1828
               +      K         S         +S       S L     S ++  S SE   
Sbjct: 3984 VRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETSR 4043

Query: 1829 GSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQV 1877
            G  P V T + R   + ++   S +     +   S    P+ P +++ +
Sbjct: 4044 GGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDI 4092



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 19/61 (31%), Positives = 31/61 (50%), Gaps = 2/61 (3%)

Query: 1098 RNKKG--NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155
            R KK   N     AA  GHL+     ++ G D++  +   +  L  A ++GHV+VV  L+
Sbjct: 35   RKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELL 94

Query: 1156 K 1156
            +
Sbjct: 95   Q 95



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 85/416 (20%), Positives = 149/416 (35%), Gaps = 53/416 (12%)

Query: 1417 SGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRS 1476
            SG  S+  S + +   S   S  + S PSP+ S  G  T +S K          +V    
Sbjct: 1519 SGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVK-------SISDVASPI 1571

Query: 1477 KKVSVPSTVISRVIGRGGCNINAIREFTG---AHIDIDKQKDKTGDRIITIRGGTESTRQ 1533
            +     S+ I  V+ +   NI           A  +    K    +   + R    +T  
Sbjct: 1572 RSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNSTFSSRTSPVTTAG 1631

Query: 1534 ATQLINALIKDPDKEIDELIPKNRLKSSSAN----SKIGSSAPTTTAANTSLMGIKMTTV 1589
            +    +++   P        PK+ +   S++    S I S+AP  ++   S++    + V
Sbjct: 1632 SLLERSSITMTPPAS-----PKSNINMYSSSLPFKSIITSAAPLISSPLKSVVSPVKSAV 1686

Query: 1590 ALSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPVSL------PLAYPPPQ-FAHA 1642
             + S+++   A             ++ +PV  +     V+L      PL YP      + 
Sbjct: 1687 DVISSAKITMA------------SSLSSPVKQMPGHAEVALVNGSISPLKYPSSSTLING 1734

Query: 1643 LLAAQTFQQ--IRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSN 1700
              A  T Q+          +         +  +      P SP R+  S  P    +   
Sbjct: 1735 CKATATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFSPLRSYVSAAPSAF-QSLR 1793

Query: 1701 QNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTT 1760
              S+ +   S GS  S+ T++ +SS  TVP  S       P++++      +  SN+ T 
Sbjct: 1794 TPSASALYTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKK------LPDSNSFTK 1847

Query: 1761 TVTTTASNNNTAPTNATYPMPTAKEHYP-VSSPSSPSPPAQPGGVSRNSPLDCGSA 1815
            +     S   T  T  T+P P    H+   SSP   S    P  +  ++P    S+
Sbjct: 1848 SAAALLSPIKTL-TTETHPQP----HFSRTSSPVKSSLFLAPSALKLSTPSSLSSS 1898



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 49/185 (26%), Positives = 72/185 (38%), Gaps = 31/185 (16%)

Query: 1262 QAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNR 1321
            Q   + EK K +  P  L     +T  TT   +AT TT          T TTTS   K R
Sbjct: 3933 QKQGQPEKGKAKQLPSKLPVKVRSTCVTTTTTTATTTTTT-------TTTTTTSCTVKVR 3985

Query: 1322 KNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDE----SSN 1377
            K+++          +    S    + ++GE+       S +   M+ S  SDE    S N
Sbjct: 3986 KSQL---------KEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQ-SELSDEEESTSRN 4035

Query: 1378 SNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLS 1437
            ++ S  S    P+V T +   KK  +  +       KS S KA    SE  S   +   S
Sbjct: 4036 TSLSETSRGGQPSVTTKSARDKKTEAAPL-------KSKSEKAG---SEKRSSRRTGPQS 4085

Query: 1438 TCTKS 1442
             C ++
Sbjct: 4086 PCERT 4090


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  296 bits (757), Expect = 2e-79
 Identities = 294/1012 (29%), Positives = 439/1012 (43%), Gaps = 121/1012 (11%)

Query: 295  DRGIKGDI-TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
            DR  K D  T  + AA  G++      L +  D+N  +  G   L  A   G+V +V  L
Sbjct: 38   DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97

Query: 354  LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGH 413
            L     +E   + G+T L  A  AG  EV R L+  GA +N  S +   + L +A  + H
Sbjct: 98   LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENH 156

Query: 414  LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPL 471
            LE+V+FLLE GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L
Sbjct: 157  LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------L 210

Query: 472  TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTE 531
             +AA       AA+L++   + + ++  G+TPL  AA   +  +  LLL +GA++N  T 
Sbjct: 211  HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TP 269

Query: 532  ETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGA 588
            +   T L +A   G + +   L+  GA IE       TPL  AA+ GH+ + + LL  GA
Sbjct: 270  QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329

Query: 589  NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648
             + A T  G + +  A +  H D   +LLQ  A+++  +    TPL  AA  GH    + 
Sbjct: 330  PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 389

Query: 649  LISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 708
            L+ KGA  N + A N  T L +AC   H+ V+ELLL  GA      + G T L  A+  G
Sbjct: 390  LLDKGAKPN-SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 448

Query: 709  HTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANV 768
            H  +V  LL       ++P     ++  P H   RA    V                   
Sbjct: 449  HLPIVKNLLQRG----ASPNVSNVKVETPLHMAARAGHTEV------------------- 485

Query: 769  ATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQT 828
                 ++NKA     +    TP H  AA I            +    L +    + +  T
Sbjct: 486  -AKYLLQNKAKVNAKAKDDQTPLH-CAARIGH----------TNMVKLLLENNANPNLAT 533

Query: 829  ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 888
             + H T L +A   GH E V  LLE+ AS     KKGFTPL +AA  G V V E+LL+  
Sbjct: 534  TAGH-TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 592

Query: 889  ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 948
            A   A  +    TPL +A      ++V+LLL RG +      + YTPL +AA    V + 
Sbjct: 593  AHPNAAGKNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 651

Query: 949  KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1008
            + LL  G   N+   S  G++PL LAA  GH   V LLL   ++ N   ++   T L L 
Sbjct: 652  RSLLQYGGSANAE--SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHLV 708

Query: 1009 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1068
              +G   V  +L+     V+   + G TPL  A+  G  ++ + LL   ADVNA      
Sbjct: 709  AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA------ 762

Query: 1069 RDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADV 1128
                                         + K G +PL  AA  GH D+V LL++ GA  
Sbjct: 763  -----------------------------KTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 793

Query: 1129 DAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCME 1188
            +   +   TPL  A R G++ V   L K V    S          ++DK  +       E
Sbjct: 794  NEVSSDGTTPLAIAKRLGYISVTDVL-KVVTDETS-------FVLVSDKHRMS----FPE 841

Query: 1189 SIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKL 1248
            ++ +  D    E   + +I+ EEL   K          A +R+ R     K+  +   KL
Sbjct: 842  TVDEILDVSEDEGTAHITIMGEELISFK----------AERRDSRDVDEEKELLDFVPKL 891

Query: 1249 EE---------IEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTI 1291
            ++         I     E   +++ ++++  K  DE  ++   P+  T+  I
Sbjct: 892  DQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNI 943



 Score =  293 bits (750), Expect = 1e-78
 Identities = 265/859 (30%), Positives = 406/859 (47%), Gaps = 67/859 (7%)

Query: 237  SLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 296
            S   A   G+++     L  G  +N   + G + L LA   G+ ++   LL     +E  
Sbjct: 48   SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 107

Query: 297  GIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
              KG+ T L  AA  G  ++V+ L+ + A+VNAQS  G T L  A    +++VVK LLE+
Sbjct: 108  TKKGN-TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166

Query: 357  GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416
            GA+     E+G TPL  A   GH  V   L+  G        + +  AL +A        
Sbjct: 167  GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRT 221

Query: 417  VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 476
               LL+   + +  +    T L  A    ++ VA+LLL+ GA VN    +  +PL +A+ 
Sbjct: 222  AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 281

Query: 477  GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQET 536
             G+V +  LL++RGA +E    +  TPL  AAR GH  +  +LL  GA I A+T+    +
Sbjct: 282  RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-S 340

Query: 537  ALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHAT 593
             + +A  G  L+    L++  A   DI L   TPL  AA  GH  + K LL  GA  ++ 
Sbjct: 341  PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 400

Query: 594  TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653
               G T L  AC+  H  V ++LL+ GA ++  +E G TPL  A+  GH+  V+ L+ +G
Sbjct: 401  ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 460

Query: 654  ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
            A+ N +    + T L +A   GH  V + LL + A    + KD  T L  AA+ GHT++V
Sbjct: 461  ASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 519

Query: 714  CYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLP 773
              LL+   N      P++   T   H             P+ +  +E      +V T L 
Sbjct: 520  KLLLENNAN------PNLA--TTAGH------------TPLHIAARE-----GHVETVLA 554

Query: 774  IRNKAVSGRASAMSN-TPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTES-- 830
            +  K  S         TP H +AA   +         +  + +L     ++ DA   +  
Sbjct: 555  LLEKEASQACMTKKGFTPLH-VAAKYGK---------VRVAELL-----LERDAHPNAAG 599

Query: 831  -NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
             N  T L +A    + ++V+ LL RG S       G+TPL +AA    V V   LL  G 
Sbjct: 600  KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659

Query: 890  DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949
               A+S +   TPL LA   G  E+V LLL++ AN    N S  TPL L A  G+V +  
Sbjct: 660  SANAESVQGV-TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVAD 718

Query: 950  ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009
            +L+  G  +++ T  ++G +PL +A+  G+   VK LL   +D+NA+ +    + L  A 
Sbjct: 719  VLIKHGVMVDATT--RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSPLHQAA 775

Query: 1010 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY---AEVGRVLLDKG-----ADVN 1061
             QG T++V+LLL   A+    +  G TPL  A   GY    +V +V+ D+      +D +
Sbjct: 776  QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH 835

Query: 1062 APPVPSSRDTALTIAADKG 1080
                P + D  L ++ D+G
Sbjct: 836  RMSFPETVDEILDVSEDEG 854



 Score =  281 bits (718), Expect = 7e-75
 Identities = 250/817 (30%), Positives = 377/817 (46%), Gaps = 81/817 (9%)

Query: 204 LTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEH 263
           L ++ S  LD+A   L      +T N  Q+    L  A  EG V  V +LL +   +   
Sbjct: 50  LRAARSGNLDKALDHLRNGVDINTCN--QNGLNGLHLASKEGHVKMVVELLHKEIILETT 107

Query: 264 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323
           T++G + L +A  AG  E+ + L+   ANV  +  KG  TPL  AA   H+++VK LL +
Sbjct: 108 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQENHLEVVKFLLEN 166

Query: 324 KADVNAQSSTGNTALTYACAGGYVDVV-----------------------------KVLL 354
            A+ N  +  G T L  A   G+ +VV                              VLL
Sbjct: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 226

Query: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGH 413
           ++  + +  ++ G TPL  A    ++ VA+LLL  GA +N T  N    + L +A  +G+
Sbjct: 227 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--TPLHIASRRGN 284

Query: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473
           + MVR LL+ GA  E KT +  T L  A  +GHV ++ +LLD GA +     +  SP+ +
Sbjct: 285 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 344

Query: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533
           AA G H++   LL++  A ++++  +  TPL  AA  GH  +  +LL +GA  N++    
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LN 403

Query: 534 QETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANV 590
             T L +AC    + V + L+K GA I+       TPL  A+  GHL +VK LL  GA+ 
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463

Query: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650
           + +    +T L  A   GHT+VA  LLQ  A +  +++  +TPL  AAR GH   V+ L+
Sbjct: 464 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 523

Query: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710
              AN N  T    HT L +A   GH+  V  LL   A      K G T L  AAK G  
Sbjct: 524 ENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 582

Query: 711 SVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-PQEPDKPPANVA 769
            V   LL+   +  +A    +T L    H  N      +  + +++P    P  P  N  
Sbjct: 583 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRGGSPHSPAWNGY 636

Query: 770 TTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTE 829
           T  P+   A   +     +   +  +A+    Q  TP                       
Sbjct: 637 T--PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP----------------------- 671

Query: 830 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
                 L LA   GH E+V  LL + A+    +K G TPL L A  GHV V ++L+ +G 
Sbjct: 672 ------LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 725

Query: 890 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949
            ++A + R   TPL +A   G  ++V+ LL   A+   +    Y+PL  AA  G+ +I+ 
Sbjct: 726 MVDA-TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVT 784

Query: 950 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986
           +LL  GA  N  +    G +PL +A   G+ +   +L
Sbjct: 785 LLLKNGASPNEVSSD--GTTPLAIAKRLGYISVTDVL 819


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  295 bits (756), Expect = 3e-79
 Identities = 287/994 (28%), Positives = 428/994 (43%), Gaps = 110/994 (11%)

Query: 303  TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
            T  + AA  G++      L +  D+N  +  G   L  A   G+V +V  LL     +E 
Sbjct: 14   TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 363  HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
              + G+T L  A  AG  EV R L+  GA +N  S +   + L +A  + HLE+V+FLLE
Sbjct: 74   TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132

Query: 423  AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 480
             GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 133  NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186

Query: 481  ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
              AA+L++   + + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 187  RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245

Query: 541  ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
            A   G + +   L+  GA IE       TPL  AA+ GH+ + + LL  GA + A T  G
Sbjct: 246  ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 598  DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
             + +  A +  H D   +LLQ  A+++  +    TPL  AA  GH    + L+ KGA  N
Sbjct: 306  LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 658  RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
             + A N  T L +AC   H+ V+ELLL  GA      + G T L  A+  GH  +V  LL
Sbjct: 366  -SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 718  DYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNK 777
                   ++P     ++  P H   RA    V                        ++NK
Sbjct: 425  QRG----ASPNVSNVKVETPLHMAARAGHTEV--------------------AKYLLQNK 460

Query: 778  AVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALT 837
            A     +    TP H  AA I            +    L +    + +  T + H T L 
Sbjct: 461  AKVNAKAKDDQTPLH-CAARIGH----------TNMVKLLLENNANPNLATTAGH-TPLH 508

Query: 838  LACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 897
            +A   GH E V  LLE+ AS     KKGFTPL +AA  G V V E+LL+  A   A  + 
Sbjct: 509  IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568

Query: 898  TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 957
               TPL +A      ++V+LLL RG +      + YTPL +AA    V + + LL  G  
Sbjct: 569  GL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627

Query: 958  INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1017
             N+   S  G++PL LAA  GH   V LLL   ++ N   ++   T L L   +G   V 
Sbjct: 628  ANAE--SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVA 684

Query: 1018 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAA 1077
             +L+     V+   + G TPL  A+  G  ++ + LL   ADVNA               
Sbjct: 685  DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA--------------- 729

Query: 1078 DKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKIT 1137
                                + K G +PL  AA  GH D+V LL++ GA  +   +   T
Sbjct: 730  --------------------KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769

Query: 1138 PLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQ 1197
            PL  A R G++ V   L K V    S          ++DK  +       E++ +  D  
Sbjct: 770  PLAIAKRLGYISVTDVL-KVVTDETS-------FVLVSDKHRMS----FPETVDEILDVS 817

Query: 1198 AAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKE 1257
              E  +  S   E  D   + EE   L    K ++  E            +  I     E
Sbjct: 818  EDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVES---------PAIPRIPCAMPE 868

Query: 1258 NFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTI 1291
               +++ ++++  K  DE  ++   P+  T+  I
Sbjct: 869  TVVIRSEEQEQASKEYDEDSLIPSSPATETSDNI 902



 Score =  281 bits (718), Expect = 7e-75
 Identities = 250/828 (30%), Positives = 376/828 (45%), Gaps = 95/828 (11%)

Query: 209 SCALDEAAAALTRMRAESTAN----------------AGQSDNRSLAEACSEGDVNAVRK 252
           S    EA AA + +RA  + N                  Q+    L  A  EG V  V +
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 253 LLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
           LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG  TPL  AA   
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQEN 122

Query: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVV---------------------- 350
           H+++VK LL + A+ N  +  G T L  A   G+ +VV                      
Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182

Query: 351 -------KVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKE 402
                   VLL++  + +  ++ G TPL  A    ++ VA+LLL  GA +N T  N    
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI-- 240

Query: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
           + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++ +LLD GA +  
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
              +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  GH  +  +LL +
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLEL 579
           GA  N++      T L +AC    + V + L+K GA I+       TPL  A+  GHL +
Sbjct: 361 GAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
           VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A +  +++  +TPL  AAR
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
            GH   V+ L+   AN N  T    HT L +A   GH+  V  LL   A      K G T
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538

Query: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-P 758
            L  AAK G   V   LL+   +  +A    +T L    H  N      +  + +++P  
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRG 592

Query: 759 QEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPI 818
             P  P  N  T  P+   A   +     +   +  +A+    Q  TP            
Sbjct: 593 GSPHSPAWNGYT--PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP------------ 638

Query: 819 YPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHV 878
                            L LA   GH E+V  LL + A+    +K G TPL L A  GHV
Sbjct: 639 -----------------LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 879 GVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 938
            V ++L+ +G  ++A + R   TPL +A   G  ++V+ LL   A+   +    Y+PL  
Sbjct: 682 PVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740

Query: 939 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986
           AA  G+ +I+ +LL  GA  N  +    G +PL +A   G+ +   +L
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSD--GTTPLAIAKRLGYISVTDVL 786



 Score =  225 bits (574), Expect = 3e-58
 Identities = 189/604 (31%), Positives = 292/604 (48%), Gaps = 32/604 (5%)

Query: 561  ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
            E   +T  + AA+ G+L+     L  G +++     G   L  A + GH  +   LL   
Sbjct: 9    EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 621  ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680
              LE  ++ G T L  AA AG    V+ L++ GANVN   +    T L +A    HL VV
Sbjct: 69   IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127

Query: 681  ELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY-PNNLLSAPPPDVTQLTPPSH 739
            + LL +GA+     +DG T L  A + GH +VV +L++Y     +  P   +       +
Sbjct: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA----ARN 183

Query: 740  DLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKA--VSGRASAMSNTPTHSIAAS 797
            D  R   V +Q  P      +    P ++A      N A  +  R ++++ TP + I   
Sbjct: 184  DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--- 240

Query: 798  ISQPQTPTPSPIISPSA-MLPIYPAIDIDAQTESNHDTALT-LACA--GGHEELVQTLLE 853
                   TP  I S    ++ +   +D  AQ E+     LT L CA   GH  + + LL+
Sbjct: 241  -------TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293

Query: 854  RGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD--TPLSLACSGGR 911
             GA I+ + K G +P+ +AA   H+  V +LL   A+I+   + T D  TPL +A   G 
Sbjct: 294  HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID---DITLDHLTPLHVAAHCGH 350

Query: 912  QEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPL 971
              V ++LL +GA    R ++ +TPL +A    +V ++++LL  GA I++ T S  G++PL
Sbjct: 351  HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES--GLTPL 408

Query: 972  MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1031
             +A+  GH   VK LL  G+  N        T L +A   G TEV   LL  KA V  +A
Sbjct: 409  HVASFMGHLPIVKNLLQRGASPNVS-NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1091
            K   TPL  AA  G+  + ++LL+  A+ N     ++  T L IAA +GH +    L+ +
Sbjct: 468  KDDQTPLHCAARIGHTNMVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 1092 GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVV 1151
             A      KKG TPL +AA  G + V +LL++  A  +AA    +TPL  A    ++ +V
Sbjct: 526  EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585

Query: 1152 RYLV 1155
            + L+
Sbjct: 586  KLLL 589



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 2/131 (1%)

Query: 1026 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1085
            +V  R     T  + AA  G  +     L  G D+N      +    L +A+ +GH K  
Sbjct: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61

Query: 1086 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1145
              L+ +   ++   KKGNT L +AA  G  +VV+ LV  GA+V+A   +  TPL  A ++
Sbjct: 62   VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121

Query: 1146 GHVKVVRYLVK 1156
             H++VV++L++
Sbjct: 122  NHLEVVKFLLE 132


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  295 bits (756), Expect = 3e-79
 Identities = 287/994 (28%), Positives = 428/994 (43%), Gaps = 110/994 (11%)

Query: 303  TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
            T  + AA  G++      L +  D+N  +  G   L  A   G+V +V  LL     +E 
Sbjct: 14   TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 363  HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
              + G+T L  A  AG  EV R L+  GA +N  S +   + L +A  + HLE+V+FLLE
Sbjct: 74   TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132

Query: 423  AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 480
             GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 133  NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186

Query: 481  ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
              AA+L++   + + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 187  RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245

Query: 541  ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
            A   G + +   L+  GA IE       TPL  AA+ GH+ + + LL  GA + A T  G
Sbjct: 246  ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 598  DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
             + +  A +  H D   +LLQ  A+++  +    TPL  AA  GH    + L+ KGA  N
Sbjct: 306  LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 658  RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
             + A N  T L +AC   H+ V+ELLL  GA      + G T L  A+  GH  +V  LL
Sbjct: 366  -SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 718  DYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNK 777
                   ++P     ++  P H   RA    V                        ++NK
Sbjct: 425  QRG----ASPNVSNVKVETPLHMAARAGHTEV--------------------AKYLLQNK 460

Query: 778  AVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALT 837
            A     +    TP H  AA I            +    L +    + +  T + H T L 
Sbjct: 461  AKVNAKAKDDQTPLH-CAARIGH----------TNMVKLLLENNANPNLATTAGH-TPLH 508

Query: 838  LACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 897
            +A   GH E V  LLE+ AS     KKGFTPL +AA  G V V E+LL+  A   A  + 
Sbjct: 509  IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568

Query: 898  TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 957
               TPL +A      ++V+LLL RG +      + YTPL +AA    V + + LL  G  
Sbjct: 569  GL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627

Query: 958  INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1017
             N+   S  G++PL LAA  GH   V LLL   ++ N   ++   T L L   +G   V 
Sbjct: 628  ANAE--SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVA 684

Query: 1018 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAA 1077
             +L+     V+   + G TPL  A+  G  ++ + LL   ADVNA               
Sbjct: 685  DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA--------------- 729

Query: 1078 DKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKIT 1137
                                + K G +PL  AA  GH D+V LL++ GA  +   +   T
Sbjct: 730  --------------------KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769

Query: 1138 PLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQ 1197
            PL  A R G++ V   L K V    S          ++DK  +       E++ +  D  
Sbjct: 770  PLAIAKRLGYISVTDVL-KVVTDETS-------FVLVSDKHRMS----FPETVDEILDVS 817

Query: 1198 AAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKE 1257
              E  +  S   E  D   + EE   L    K ++  E            +  I     E
Sbjct: 818  EDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVES---------PAIPRIPCAMPE 868

Query: 1258 NFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTI 1291
               +++ ++++  K  DE  ++   P+  T+  I
Sbjct: 869  TVVIRSEEQEQASKEYDEDSLIPSSPATETSDNI 902



 Score =  281 bits (718), Expect = 7e-75
 Identities = 250/828 (30%), Positives = 376/828 (45%), Gaps = 95/828 (11%)

Query: 209 SCALDEAAAALTRMRAESTAN----------------AGQSDNRSLAEACSEGDVNAVRK 252
           S    EA AA + +RA  + N                  Q+    L  A  EG V  V +
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 253 LLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
           LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG  TPL  AA   
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQEN 122

Query: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVV---------------------- 350
           H+++VK LL + A+ N  +  G T L  A   G+ +VV                      
Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182

Query: 351 -------KVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKE 402
                   VLL++  + +  ++ G TPL  A    ++ VA+LLL  GA +N T  N    
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI-- 240

Query: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
           + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++ +LLD GA +  
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
              +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  GH  +  +LL +
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLEL 579
           GA  N++      T L +AC    + V + L+K GA I+       TPL  A+  GHL +
Sbjct: 361 GAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
           VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A +  +++  +TPL  AAR
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
            GH   V+ L+   AN N  T    HT L +A   GH+  V  LL   A      K G T
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538

Query: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-P 758
            L  AAK G   V   LL+   +  +A    +T L    H  N      +  + +++P  
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRG 592

Query: 759 QEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPI 818
             P  P  N  T  P+   A   +     +   +  +A+    Q  TP            
Sbjct: 593 GSPHSPAWNGYT--PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP------------ 638

Query: 819 YPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHV 878
                            L LA   GH E+V  LL + A+    +K G TPL L A  GHV
Sbjct: 639 -----------------LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 879 GVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 938
            V ++L+ +G  ++A + R   TPL +A   G  ++V+ LL   A+   +    Y+PL  
Sbjct: 682 PVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740

Query: 939 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986
           AA  G+ +I+ +LL  GA  N  +    G +PL +A   G+ +   +L
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSD--GTTPLAIAKRLGYISVTDVL 786



 Score =  225 bits (574), Expect = 3e-58
 Identities = 189/604 (31%), Positives = 292/604 (48%), Gaps = 32/604 (5%)

Query: 561  ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
            E   +T  + AA+ G+L+     L  G +++     G   L  A + GH  +   LL   
Sbjct: 9    EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 621  ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680
              LE  ++ G T L  AA AG    V+ L++ GANVN   +    T L +A    HL VV
Sbjct: 69   IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127

Query: 681  ELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY-PNNLLSAPPPDVTQLTPPSH 739
            + LL +GA+     +DG T L  A + GH +VV +L++Y     +  P   +       +
Sbjct: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA----ARN 183

Query: 740  DLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKA--VSGRASAMSNTPTHSIAAS 797
            D  R   V +Q  P      +    P ++A      N A  +  R ++++ TP + I   
Sbjct: 184  DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--- 240

Query: 798  ISQPQTPTPSPIISPSA-MLPIYPAIDIDAQTESNHDTALT-LACA--GGHEELVQTLLE 853
                   TP  I S    ++ +   +D  AQ E+     LT L CA   GH  + + LL+
Sbjct: 241  -------TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293

Query: 854  RGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD--TPLSLACSGGR 911
             GA I+ + K G +P+ +AA   H+  V +LL   A+I+   + T D  TPL +A   G 
Sbjct: 294  HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID---DITLDHLTPLHVAAHCGH 350

Query: 912  QEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPL 971
              V ++LL +GA    R ++ +TPL +A    +V ++++LL  GA I++ T S  G++PL
Sbjct: 351  HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES--GLTPL 408

Query: 972  MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1031
             +A+  GH   VK LL  G+  N        T L +A   G TEV   LL  KA V  +A
Sbjct: 409  HVASFMGHLPIVKNLLQRGASPNVS-NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1091
            K   TPL  AA  G+  + ++LL+  A+ N     ++  T L IAA +GH +    L+ +
Sbjct: 468  KDDQTPLHCAARIGHTNMVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 1092 GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVV 1151
             A      KKG TPL +AA  G + V +LL++  A  +AA    +TPL  A    ++ +V
Sbjct: 526  EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585

Query: 1152 RYLV 1155
            + L+
Sbjct: 586  KLLL 589



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 2/131 (1%)

Query: 1026 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1085
            +V  R     T  + AA  G  +     L  G D+N      +    L +A+ +GH K  
Sbjct: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61

Query: 1086 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1145
              L+ +   ++   KKGNT L +AA  G  +VV+ LV  GA+V+A   +  TPL  A ++
Sbjct: 62   VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121

Query: 1146 GHVKVVRYLVK 1156
             H++VV++L++
Sbjct: 122  NHLEVVKFLLE 132


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  295 bits (756), Expect = 3e-79
 Identities = 287/994 (28%), Positives = 428/994 (43%), Gaps = 110/994 (11%)

Query: 303  TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
            T  + AA  G++      L +  D+N  +  G   L  A   G+V +V  LL     +E 
Sbjct: 14   TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 363  HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
              + G+T L  A  AG  EV R L+  GA +N  S +   + L +A  + HLE+V+FLLE
Sbjct: 74   TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132

Query: 423  AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 480
             GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 133  NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186

Query: 481  ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
              AA+L++   + + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 187  RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245

Query: 541  ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
            A   G + +   L+  GA IE       TPL  AA+ GH+ + + LL  GA + A T  G
Sbjct: 246  ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 598  DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
             + +  A +  H D   +LLQ  A+++  +    TPL  AA  GH    + L+ KGA  N
Sbjct: 306  LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 658  RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
             + A N  T L +AC   H+ V+ELLL  GA      + G T L  A+  GH  +V  LL
Sbjct: 366  -SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 718  DYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNK 777
                   ++P     ++  P H   RA    V                        ++NK
Sbjct: 425  QRG----ASPNVSNVKVETPLHMAARAGHTEV--------------------AKYLLQNK 460

Query: 778  AVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALT 837
            A     +    TP H  AA I            +    L +    + +  T + H T L 
Sbjct: 461  AKVNAKAKDDQTPLH-CAARIGH----------TNMVKLLLENNANPNLATTAGH-TPLH 508

Query: 838  LACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 897
            +A   GH E V  LLE+ AS     KKGFTPL +AA  G V V E+LL+  A   A  + 
Sbjct: 509  IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568

Query: 898  TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 957
               TPL +A      ++V+LLL RG +      + YTPL +AA    V + + LL  G  
Sbjct: 569  GL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627

Query: 958  INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1017
             N+   S  G++PL LAA  GH   V LLL   ++ N   ++   T L L   +G   V 
Sbjct: 628  ANAE--SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVA 684

Query: 1018 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAA 1077
             +L+     V+   + G TPL  A+  G  ++ + LL   ADVNA               
Sbjct: 685  DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA--------------- 729

Query: 1078 DKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKIT 1137
                                + K G +PL  AA  GH D+V LL++ GA  +   +   T
Sbjct: 730  --------------------KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769

Query: 1138 PLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQ 1197
            PL  A R G++ V   L K V    S          ++DK  +       E++ +  D  
Sbjct: 770  PLAIAKRLGYISVTDVL-KVVTDETS-------FVLVSDKHRMS----FPETVDEILDVS 817

Query: 1198 AAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKE 1257
              E  +  S   E  D   + EE   L    K ++  E            +  I     E
Sbjct: 818  EDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVES---------PAIPRIPCAMPE 868

Query: 1258 NFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTI 1291
               +++ ++++  K  DE  ++   P+  T+  I
Sbjct: 869  TVVIRSEEQEQASKEYDEDSLIPSSPATETSDNI 902



 Score =  281 bits (718), Expect = 7e-75
 Identities = 250/828 (30%), Positives = 376/828 (45%), Gaps = 95/828 (11%)

Query: 209 SCALDEAAAALTRMRAESTAN----------------AGQSDNRSLAEACSEGDVNAVRK 252
           S    EA AA + +RA  + N                  Q+    L  A  EG V  V +
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 253 LLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
           LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG  TPL  AA   
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQEN 122

Query: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVV---------------------- 350
           H+++VK LL + A+ N  +  G T L  A   G+ +VV                      
Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182

Query: 351 -------KVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKE 402
                   VLL++  + +  ++ G TPL  A    ++ VA+LLL  GA +N T  N    
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI-- 240

Query: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
           + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++ +LLD GA +  
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
              +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  GH  +  +LL +
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLEL 579
           GA  N++      T L +AC    + V + L+K GA I+       TPL  A+  GHL +
Sbjct: 361 GAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
           VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A +  +++  +TPL  AAR
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
            GH   V+ L+   AN N  T    HT L +A   GH+  V  LL   A      K G T
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538

Query: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-P 758
            L  AAK G   V   LL+   +  +A    +T L    H  N      +  + +++P  
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRG 592

Query: 759 QEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPI 818
             P  P  N  T  P+   A   +     +   +  +A+    Q  TP            
Sbjct: 593 GSPHSPAWNGYT--PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP------------ 638

Query: 819 YPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHV 878
                            L LA   GH E+V  LL + A+    +K G TPL L A  GHV
Sbjct: 639 -----------------LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 879 GVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 938
            V ++L+ +G  ++A + R   TPL +A   G  ++V+ LL   A+   +    Y+PL  
Sbjct: 682 PVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740

Query: 939 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986
           AA  G+ +I+ +LL  GA  N  +    G +PL +A   G+ +   +L
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSD--GTTPLAIAKRLGYISVTDVL 786



 Score =  225 bits (574), Expect = 3e-58
 Identities = 189/604 (31%), Positives = 292/604 (48%), Gaps = 32/604 (5%)

Query: 561  ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
            E   +T  + AA+ G+L+     L  G +++     G   L  A + GH  +   LL   
Sbjct: 9    EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 621  ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680
              LE  ++ G T L  AA AG    V+ L++ GANVN   +    T L +A    HL VV
Sbjct: 69   IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127

Query: 681  ELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY-PNNLLSAPPPDVTQLTPPSH 739
            + LL +GA+     +DG T L  A + GH +VV +L++Y     +  P   +       +
Sbjct: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA----ARN 183

Query: 740  DLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKA--VSGRASAMSNTPTHSIAAS 797
            D  R   V +Q  P      +    P ++A      N A  +  R ++++ TP + I   
Sbjct: 184  DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--- 240

Query: 798  ISQPQTPTPSPIISPSA-MLPIYPAIDIDAQTESNHDTALT-LACA--GGHEELVQTLLE 853
                   TP  I S    ++ +   +D  AQ E+     LT L CA   GH  + + LL+
Sbjct: 241  -------TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293

Query: 854  RGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD--TPLSLACSGGR 911
             GA I+ + K G +P+ +AA   H+  V +LL   A+I+   + T D  TPL +A   G 
Sbjct: 294  HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID---DITLDHLTPLHVAAHCGH 350

Query: 912  QEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPL 971
              V ++LL +GA    R ++ +TPL +A    +V ++++LL  GA I++ T S  G++PL
Sbjct: 351  HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES--GLTPL 408

Query: 972  MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1031
             +A+  GH   VK LL  G+  N        T L +A   G TEV   LL  KA V  +A
Sbjct: 409  HVASFMGHLPIVKNLLQRGASPNVS-NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1091
            K   TPL  AA  G+  + ++LL+  A+ N     ++  T L IAA +GH +    L+ +
Sbjct: 468  KDDQTPLHCAARIGHTNMVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 1092 GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVV 1151
             A      KKG TPL +AA  G + V +LL++  A  +AA    +TPL  A    ++ +V
Sbjct: 526  EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585

Query: 1152 RYLV 1155
            + L+
Sbjct: 586  KLLL 589



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 2/131 (1%)

Query: 1026 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1085
            +V  R     T  + AA  G  +     L  G D+N      +    L +A+ +GH K  
Sbjct: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61

Query: 1086 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1145
              L+ +   ++   KKGNT L +AA  G  +VV+ LV  GA+V+A   +  TPL  A ++
Sbjct: 62   VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121

Query: 1146 GHVKVVRYLVK 1156
             H++VV++L++
Sbjct: 122  NHLEVVKFLLE 132


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  295 bits (756), Expect = 3e-79
 Identities = 287/994 (28%), Positives = 428/994 (43%), Gaps = 110/994 (11%)

Query: 303  TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
            T  + AA  G++      L +  D+N  +  G   L  A   G+V +V  LL     +E 
Sbjct: 14   TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 363  HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
              + G+T L  A  AG  EV R L+  GA +N  S +   + L +A  + HLE+V+FLLE
Sbjct: 74   TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132

Query: 423  AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 480
             GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 133  NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186

Query: 481  ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
              AA+L++   + + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 187  RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245

Query: 541  ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
            A   G + +   L+  GA IE       TPL  AA+ GH+ + + LL  GA + A T  G
Sbjct: 246  ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 598  DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
             + +  A +  H D   +LLQ  A+++  +    TPL  AA  GH    + L+ KGA  N
Sbjct: 306  LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 658  RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
             + A N  T L +AC   H+ V+ELLL  GA      + G T L  A+  GH  +V  LL
Sbjct: 366  -SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 718  DYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNK 777
                   ++P     ++  P H   RA    V                        ++NK
Sbjct: 425  QRG----ASPNVSNVKVETPLHMAARAGHTEV--------------------AKYLLQNK 460

Query: 778  AVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALT 837
            A     +    TP H  AA I            +    L +    + +  T + H T L 
Sbjct: 461  AKVNAKAKDDQTPLH-CAARIGH----------TNMVKLLLENNANPNLATTAGH-TPLH 508

Query: 838  LACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 897
            +A   GH E V  LLE+ AS     KKGFTPL +AA  G V V E+LL+  A   A  + 
Sbjct: 509  IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568

Query: 898  TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 957
               TPL +A      ++V+LLL RG +      + YTPL +AA    V + + LL  G  
Sbjct: 569  GL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627

Query: 958  INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1017
             N+   S  G++PL LAA  GH   V LLL   ++ N   ++   T L L   +G   V 
Sbjct: 628  ANAE--SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVA 684

Query: 1018 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAA 1077
             +L+     V+   + G TPL  A+  G  ++ + LL   ADVNA               
Sbjct: 685  DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA--------------- 729

Query: 1078 DKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKIT 1137
                                + K G +PL  AA  GH D+V LL++ GA  +   +   T
Sbjct: 730  --------------------KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769

Query: 1138 PLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQ 1197
            PL  A R G++ V   L K V    S          ++DK  +       E++ +  D  
Sbjct: 770  PLAIAKRLGYISVTDVL-KVVTDETS-------FVLVSDKHRMS----FPETVDEILDVS 817

Query: 1198 AAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKE 1257
              E  +  S   E  D   + EE   L    K ++  E            +  I     E
Sbjct: 818  EDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVES---------PAIPRIPCAMPE 868

Query: 1258 NFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTI 1291
               +++ ++++  K  DE  ++   P+  T+  I
Sbjct: 869  TVVIRSEEQEQASKEYDEDSLIPSSPATETSDNI 902



 Score =  281 bits (718), Expect = 7e-75
 Identities = 250/828 (30%), Positives = 376/828 (45%), Gaps = 95/828 (11%)

Query: 209 SCALDEAAAALTRMRAESTAN----------------AGQSDNRSLAEACSEGDVNAVRK 252
           S    EA AA + +RA  + N                  Q+    L  A  EG V  V +
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 253 LLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
           LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG  TPL  AA   
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQEN 122

Query: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVV---------------------- 350
           H+++VK LL + A+ N  +  G T L  A   G+ +VV                      
Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182

Query: 351 -------KVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKE 402
                   VLL++  + +  ++ G TPL  A    ++ VA+LLL  GA +N T  N    
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI-- 240

Query: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
           + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++ +LLD GA +  
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
              +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  GH  +  +LL +
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLEL 579
           GA  N++      T L +AC    + V + L+K GA I+       TPL  A+  GHL +
Sbjct: 361 GAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
           VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A +  +++  +TPL  AAR
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
            GH   V+ L+   AN N  T    HT L +A   GH+  V  LL   A      K G T
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538

Query: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-P 758
            L  AAK G   V   LL+   +  +A    +T L    H  N      +  + +++P  
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRG 592

Query: 759 QEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPI 818
             P  P  N  T  P+   A   +     +   +  +A+    Q  TP            
Sbjct: 593 GSPHSPAWNGYT--PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP------------ 638

Query: 819 YPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHV 878
                            L LA   GH E+V  LL + A+    +K G TPL L A  GHV
Sbjct: 639 -----------------LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 879 GVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 938
            V ++L+ +G  ++A + R   TPL +A   G  ++V+ LL   A+   +    Y+PL  
Sbjct: 682 PVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740

Query: 939 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986
           AA  G+ +I+ +LL  GA  N  +    G +PL +A   G+ +   +L
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSD--GTTPLAIAKRLGYISVTDVL 786



 Score =  225 bits (574), Expect = 3e-58
 Identities = 189/604 (31%), Positives = 292/604 (48%), Gaps = 32/604 (5%)

Query: 561  ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
            E   +T  + AA+ G+L+     L  G +++     G   L  A + GH  +   LL   
Sbjct: 9    EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 621  ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680
              LE  ++ G T L  AA AG    V+ L++ GANVN   +    T L +A    HL VV
Sbjct: 69   IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127

Query: 681  ELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY-PNNLLSAPPPDVTQLTPPSH 739
            + LL +GA+     +DG T L  A + GH +VV +L++Y     +  P   +       +
Sbjct: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA----ARN 183

Query: 740  DLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKA--VSGRASAMSNTPTHSIAAS 797
            D  R   V +Q  P      +    P ++A      N A  +  R ++++ TP + I   
Sbjct: 184  DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--- 240

Query: 798  ISQPQTPTPSPIISPSA-MLPIYPAIDIDAQTESNHDTALT-LACA--GGHEELVQTLLE 853
                   TP  I S    ++ +   +D  AQ E+     LT L CA   GH  + + LL+
Sbjct: 241  -------TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293

Query: 854  RGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD--TPLSLACSGGR 911
             GA I+ + K G +P+ +AA   H+  V +LL   A+I+   + T D  TPL +A   G 
Sbjct: 294  HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID---DITLDHLTPLHVAAHCGH 350

Query: 912  QEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPL 971
              V ++LL +GA    R ++ +TPL +A    +V ++++LL  GA I++ T S  G++PL
Sbjct: 351  HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES--GLTPL 408

Query: 972  MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1031
             +A+  GH   VK LL  G+  N        T L +A   G TEV   LL  KA V  +A
Sbjct: 409  HVASFMGHLPIVKNLLQRGASPNVS-NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1091
            K   TPL  AA  G+  + ++LL+  A+ N     ++  T L IAA +GH +    L+ +
Sbjct: 468  KDDQTPLHCAARIGHTNMVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 1092 GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVV 1151
             A      KKG TPL +AA  G + V +LL++  A  +AA    +TPL  A    ++ +V
Sbjct: 526  EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585

Query: 1152 RYLV 1155
            + L+
Sbjct: 586  KLLL 589



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 2/131 (1%)

Query: 1026 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1085
            +V  R     T  + AA  G  +     L  G D+N      +    L +A+ +GH K  
Sbjct: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61

Query: 1086 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1145
              L+ +   ++   KKGNT L +AA  G  +VV+ LV  GA+V+A   +  TPL  A ++
Sbjct: 62   VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121

Query: 1146 GHVKVVRYLVK 1156
             H++VV++L++
Sbjct: 122  NHLEVVKFLLE 132


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  278 bits (711), Expect = 5e-74
 Identities = 262/960 (27%), Positives = 412/960 (42%), Gaps = 111/960 (11%)

Query: 234  DNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 293
            D  SL +A   GD + VR L+ +   VN    E  + L  A   G  E+ ++L+   A V
Sbjct: 8    DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67

Query: 294  EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
              +  K  +TPL  A      + V++LL H ADVNA+     T L  A A   V   + L
Sbjct: 68   NAKDSKW-LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126

Query: 354  LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGH 413
            +   +++   +  G T L  A  +GH E+ +LLL  GA IN    + +  A+  A Y GH
Sbjct: 127  VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGH 185

Query: 414  LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473
            +E+V+ L+  GA+   K  + +T L  A   G + V + LLD G  +N P     +PL +
Sbjct: 186  IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245

Query: 474  AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM-VALLLGQGANINAQTEE 532
            A   G   +   LI+ GA + + N++G+TPL  AA   H  + + LL+G GA++N ++++
Sbjct: 246  ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305

Query: 533  TQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHA 592
             +                               TPL   A  G     + ++ +GA +  
Sbjct: 306  GK-------------------------------TPLHMTALHGRFSRSQTIIQSGAVIDC 334

Query: 593  TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
                G+T L  A   GH  + + L+ +GAD       G  PL  AA +G     + L+S 
Sbjct: 335  EDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSS 394

Query: 653  GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
            G +++ T  +   T L  A AGG+L  + LLL  GAD   + K G + L  AA   +   
Sbjct: 395  GFDID-TPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQC 453

Query: 713  VCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTL 772
            +  L+    ++               +DL+     P+          + D          
Sbjct: 454  LFALVGSGASV---------------NDLDERGCTPLH----YAATSDTD----GKCLEY 490

Query: 773  PIRNKAVSGRASAMSNTPTHSIAA-----SISQPQTPTPSPIISPSAMLPIYPAIDIDAQ 827
             +RN A  G          H  AA      +    + TP  ++  ++   +    D  A 
Sbjct: 491  LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550

Query: 828  TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 887
                H     LA   GH + ++ L++    ++ R+  G TPL LAA  GHV  V++L++ 
Sbjct: 551  ISPLH-----LAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQ 605

Query: 888  GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD---YTPLSLAASGGY 944
            GA I  +    K TP+  A + G  E + LL+     +   ++ D    TPL L+   G+
Sbjct: 606  GASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGH 665

Query: 945  VNIIKILLNAGAEINSRT-------------------------GSKL------GISPLML 973
             + +  LLN GA ++++                          G+K       G +P+ L
Sbjct: 666  TDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHL 725

Query: 974  AAMNGHTAAVKLLLDMGSDINAQIETNRN---TALTLACFQGRTEVVSLLLDRKANVEHR 1030
            +A  GH   +  LL   + ++A   T  N   TAL  AC+ G    V LLL+++   +  
Sbjct: 726  SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQKT 784

Query: 1031 AKTGLTPLMEAASGGYAEVGRVLLDK-GAD-VNAPPVPSSRDTALTIAADKGHYKFCELL 1088
                 +PL  A          +L+D  GA  VNA    S   T L  AA   H +  +LL
Sbjct: 785  EGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNA--TDSKGRTPLHAAAFTDHVECLQLL 842

Query: 1089 IGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV-QAGADVDAADNRKITPLMAAFRKGH 1147
            +   A ++  +  G TPL +AA  G  + V++LV  A A++   DN K T L  A  KGH
Sbjct: 843  LSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH 902



 Score =  272 bits (695), Expect = 3e-72
 Identities = 271/931 (29%), Positives = 412/931 (44%), Gaps = 51/931 (5%)

Query: 245  GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITP 304
            GD   +  L++ G  VN    +  + L  A ++   E  QVLL   A+V  R  K   TP
Sbjct: 52   GDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARD-KNWQTP 110

Query: 305  LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
            L  AA    VK  + L+   ++VN     G TAL +A   G+ ++VK+LL  GA+I   +
Sbjct: 111  LHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFD 170

Query: 365  ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
            +     +  A   GH+EV +LL+ +GA + T  ++   + L  A   G + +V++LL+ G
Sbjct: 171  KKDRRAIHWAAYMGHIEVVKLLVSHGAEV-TCKDKKSYTPLHAAASSGMISVVKYLLDLG 229

Query: 425  ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA- 483
             D        +T L  AC +G   V   L+D GA VN   +   +PL  AA   H  L  
Sbjct: 230  VDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCL 289

Query: 484  ALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACC 543
             LL+  GA +   + +G TPL   A  G       ++  GA I+ + ++   T L +A  
Sbjct: 290  ELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE-DKNGNTPLHIAAR 348

Query: 544  GGFLEVADFLIKAGADIE---LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
             G   + + LI +GAD     +    PL  AA  G  +  + LL++G ++      G T 
Sbjct: 349  YGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTC 408

Query: 601  LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
            L  A   G+ +  ++LL  GAD   + + GR+PL  AA   +   +  L+  GA+VN   
Sbjct: 409  LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD 468

Query: 661  ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
                  +   A +      +E LL + A+P  R K G   +  +A  GH   +C  L   
Sbjct: 469  ERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHR--LCLQL--- 523

Query: 721  NNLLSAPPPDVTQLTPPSHDL----NRAPRVPV---------QALPMVVPPQEPDKPPAN 767
              + S  P DV   T  +  L    NRA   P+         QAL ++V     D    N
Sbjct: 524  --IASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLV-QSLLDLDVRN 580

Query: 768  VATTLPIRNKAVSGRASAMS---NTPTHSIAASISQPQTPTPSPIIS-PSAMLPIY---- 819
             +   P+   A  G    +    N     +       +TP  +   +  S  L +     
Sbjct: 581  SSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNA 640

Query: 820  -PAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHV 878
             P   +D Q + N  T L L+   GH + V +LL +GA+++ +DK G T L   A  GH 
Sbjct: 641  EPQNAVDIQ-DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHE 699

Query: 879  GVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL----ARGANKEHRNVSDYT 934
              V+ LL +GA    +  R + TP+ L+ + G   V+  LL    +  AN    +   YT
Sbjct: 700  ECVDALLQHGAKCLLRDSRGR-TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYT 758

Query: 935  PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD-MGSDI 993
             L  A   G+   +++LL    E+  +T      SPL  A +N +  A ++L+D +G+ I
Sbjct: 759  ALHWACYNGHETCVELLLE--QEVFQKTEGN-AFSPLHCAVINDNEGAAEMLIDTLGASI 815

Query: 994  NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1053
                ++   T L  A F    E + LLL   A V     TG TPLM AA  G      +L
Sbjct: 816  VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875

Query: 1054 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH---IDVRNKKGNTPLWLAA 1110
            +   A        +S++TAL +A  KGH     L++ +      I+  N    TPL +AA
Sbjct: 876  V-SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAA 934

Query: 1111 NGGHLDVVQLLVQAGADVDAADNRKITPLMA 1141
              G   VVQ L+  GA V A D    TP +A
Sbjct: 935  RNGLTMVVQELLGKGASVLAVDENGYTPALA 965



 Score =  229 bits (583), Expect = 3e-59
 Identities = 260/967 (26%), Positives = 399/967 (41%), Gaps = 126/967 (13%)

Query: 148  ETASKLLLSGTADGA-DLRTVDPETQARLEALLEAAGIGKLSTAD----GKAFADPEVLR 202
            E    L+LSG    A D + + P  +A      EA  +    +AD     K +  P  + 
Sbjct: 55   EIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIA 114

Query: 203  RLTSSVSCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVN 261
                +V CA  EA   L      S  N      R+ L  A   G    V+ LL  G ++N
Sbjct: 115  AANKAVKCA--EALVPLL-----SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167

Query: 262  EHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL 321
               ++    +  A   G+ E+ ++L++  A V  +  K   TPL AAA+ G + +VK LL
Sbjct: 168  AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD-KKSYTPLHAAASSGMISVVKYLL 226

Query: 322  AHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVE 381
                D+N  ++ GNT L  AC  G   VV  L++ GA +   NE G TPL  A ++ H  
Sbjct: 227  DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGA 286

Query: 382  VA-RLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
            +   LL+ NGA +N  S + K + L +    G     + ++++GA  + +    +T L  
Sbjct: 287  LCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345

Query: 441  ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500
            A   GH  +   L+ SGA           PL LAA  G  +    L+  G  ++  +D G
Sbjct: 346  AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405

Query: 501  YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI 560
             T L  AA  G+ E + LLL  GA+ N + ++   + L  A      +    L+ +GA +
Sbjct: 406  RTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQCLFALVGSGASV 464

Query: 561  ----ELGCSTPLMEAAQEGHLELVKYLLAAGAN-----------VHATTATGD------- 598
                E GC+     A  +   + ++YLL   AN           VH + A G        
Sbjct: 465  NDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI 524

Query: 599  ---------------------------TALTYACENGHTDVADVLLQAGADLEHESEGGR 631
                                       + L  A  +GH    +VL+Q+  DL+  +  GR
Sbjct: 525  ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR 584

Query: 632  TPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPT 691
            TPL  AA  GHV  V  LI++GA++         T +  A   GH   + LL+ + A+P 
Sbjct: 585  TPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGN-AEPQ 643

Query: 692  HRLK----DGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRV 747
            + +     +G T L+ +   GHT  V  LL+   N+ +      T L             
Sbjct: 644  NAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTAL------------- 690

Query: 748  PVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPS 807
                                          AV+G    +     H     +   +  TP 
Sbjct: 691  ---------------------------HRGAVTGHEECVDALLQHGAKCLLRDSRGRTPI 723

Query: 808  PIISP-------SAMLPIYPAIDIDAQTESNHD-TALTLACAGGHEELVQTLLERGASIE 859
             + +         A+L    ++D +  T  NH  TAL  AC  GHE  V+ LLE+    +
Sbjct: 724  HLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQ 782

Query: 860  HRDKKGFTPLILAATAGHVGVVEILLDN-GADIEAQSERTKDTPLSLACSGGRQEVVELL 918
              +   F+PL  A    + G  E+L+D  GA I   ++    TPL  A      E ++LL
Sbjct: 783  KTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLL 842

Query: 919  LARGANKEHRNVSDYTPLSLAASGGYVNIIKILL-NAGAEINSRTGSKLGISPLMLAAMN 977
            L+  A     + +  TPL +AA  G  N +++L+ +A AE+  +  SK   + L LA   
Sbjct: 843  LSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK--NTALHLACSK 900

Query: 978  GHTAAVKLLLDMGSDINAQIETNR--NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGL 1035
            GH  +  L+L+  +D N    TN    T L +A   G T VV  LL + A+V    + G 
Sbjct: 901  GHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY 960

Query: 1036 TPLMEAA 1042
            TP +  A
Sbjct: 961  TPALACA 967



 Score =  194 bits (494), Expect = 7e-49
 Identities = 214/779 (27%), Positives = 321/779 (41%), Gaps = 50/779 (6%)

Query: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
           L  A S G ++ V+ LL  G  +NE    G + L +AC  G   +   L+   A V  + 
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269

Query: 298 IKGDITPLMAAANGGHVKI-VKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
            KG  TPL  AA   H  + ++LL+ + ADVN +S  G T L      G     + +++S
Sbjct: 270 EKG-FTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQS 328

Query: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416
           GA I+  ++NG+TPL  A   GH  +   L+ +GA             L LA   G  + 
Sbjct: 329 GAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFPLHLAALSGFSDC 387

Query: 417 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 476
            R LL +G D +   D   T L  A   G++E   LLL++GA  N       SPL  AA 
Sbjct: 388 CRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAA 447

Query: 477 GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHE-EMVALLLGQGANINAQTEETQE 535
             + +    L+  GAS+ ++++ G TPL  AA    + + +  LL   AN   + ++   
Sbjct: 448 NCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYN 507

Query: 536 TALTLACCGGFLEVADFLIKAGADIELGCS--------------TPLMEAAQEGHLELVK 581
                A  G  L +     +   D+ +  S              +PL  AA  GH + ++
Sbjct: 508 AVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALE 567

Query: 582 YLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGAD-LEHESEGGRTPLMKAARA 640
            L+ +  ++    ++G T L  A   GH +  DVL+  GA  L  +    RTP+  AA  
Sbjct: 568 VLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATN 627

Query: 641 GHVCTVQFLISKGANVNRTTAN--NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGS 698
           GH   ++ LI      N       N  T L L+   GH   V  LL  GA+   + K G 
Sbjct: 628 GHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGR 687

Query: 699 TMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPP 758
           T L   A  GH   V  LL +    L       T    P H       + V    +    
Sbjct: 688 TALHRGAVTGHEECVDALLQHGAKCLLRDSRGRT----PIHLSAACGHIGVLGALL---- 739

Query: 759 QEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQ---------TPTPSPI 809
           Q      AN AT     N   +    A  N     +   + Q           +P    +
Sbjct: 740 QSAASMDANPATA---DNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAV 796

Query: 810 ISPSA----MLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKG 865
           I+ +     ML       I   T+S   T L  A    H E +Q LL   A +   D  G
Sbjct: 797 INDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTG 856

Query: 866 FTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANK 925
            TPL++AA  G    VE+L+ + +      + +K+T L LACS G +    L+L +  ++
Sbjct: 857 KTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDR 916

Query: 926 EHRNVSD---YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTA 981
              N ++    TPL +AA  G   +++ LL  GA +      + G +P +  A N   A
Sbjct: 917 NLINATNAALQTPLHVAARNGLTMVVQELLGKGASV--LAVDENGYTPALACAPNKDVA 973



 Score =  148 bits (373), Expect = 7e-35
 Identities = 169/651 (25%), Positives = 274/651 (42%), Gaps = 98/651 (15%)

Query: 558  ADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL 617
            A ++L     L++A   G  + V+ L+    +V+       T L  A   G  ++ ++L+
Sbjct: 2    AFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI 61

Query: 618  QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677
             +GA +  +     TPL +A  +     VQ L+   A+VN     N  T L +A A   +
Sbjct: 62   LSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN-ARDKNWQTPLHIAAANKAV 120

Query: 678  AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPP 737
               E L+   ++     + G T L  AA  GH  +V  LL    N+ +    D       
Sbjct: 121  KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD------- 173

Query: 738  SHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAAS 797
                 RA                             I   A  G    +    +H    +
Sbjct: 174  ----RRA-----------------------------IHWAAYMGHIEVVKLLVSHGAEVT 200

Query: 798  ISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNH-----DTALTLACAGGHEELVQTLL 852
                ++ TP    + S M+ +   + +D   + N      +T L +AC  G + +V  L+
Sbjct: 201  CKDKKSYTPLHAAASSGMISVVKYL-LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELI 259

Query: 853  ERGASIEHRDKKGFTPLILAATAGHVGV-VEILLDNGADIEAQSERTKDTPLSLACSGGR 911
            + GA +  +++KGFTPL  AA + H  + +E+L+ NGAD+  +S+  K TPL +    GR
Sbjct: 260  DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGR 318

Query: 912  QEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPL 971
                + ++  GA  +  + +  TPL +AA  G+  +I  L+ +GA+   R     G+ PL
Sbjct: 319  FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKR--GIHGMFPL 376

Query: 972  MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1031
             LAA++G +   + LL  G DI+   +  R T L  A   G  E ++LLL+  A+   + 
Sbjct: 377  HLAALSGFSDCCRKLLSSGFDIDTPDDFGR-TCLHAAAAGGNLECLNLLLNTGADFNKKD 435

Query: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGADVN------APPV-------------------- 1065
            K G +PL  AA+    +    L+  GA VN        P+                    
Sbjct: 436  KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRND 495

Query: 1066 --PSSRD----TALTIAADKGHYKFCELLIGRGAHIDV-------------RNKKGNTPL 1106
              P  RD     A+  +A  GH + C  LI     +DV              N+   +PL
Sbjct: 496  ANPGIRDKQGYNAVHYSAAYGH-RLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPL 554

Query: 1107 WLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
             LAA  GH   +++LVQ+  D+D  ++   TPL  A  KGHV+ V  L+ +
Sbjct: 555  HLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQ 605



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 32/122 (26%), Positives = 60/122 (49%), Gaps = 3/122 (2%)

Query: 1088 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1147
            LI +   ++ ++ +  TPL  AA  G  ++++LL+ +GA V+A D++ +TPL  A     
Sbjct: 27   LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86

Query: 1148 VKVVRYLVK---EVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKN 1204
             + V+ L+K   +VN    + +   +IA         +  + + S V   DR    A  +
Sbjct: 87   EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146

Query: 1205 AS 1206
            A+
Sbjct: 147  AA 148


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  259 bits (663), Expect = 2e-68
 Identities = 279/1040 (26%), Positives = 440/1040 (42%), Gaps = 134/1040 (12%)

Query: 233  SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 292
            +D   L +A    DV  VR LL +  ++N   +E  + L  A   G   + Q+LL   AN
Sbjct: 7    TDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGAN 66

Query: 293  VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352
            V  +     +TPL  AA   + K++ LLLAH ADVNA+     T L  A A       + 
Sbjct: 67   VNAKDTLW-LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEA 125

Query: 353  LLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKG 412
            L    +S+   + +G + L  A  +GH+E   LLL  GA +N    + ++  L  A + G
Sbjct: 126  LAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLG 184

Query: 413  HLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 472
            HLE+++ L+  GAD   K  + +  L  A   G +EV + LL  GA+++ P     + L 
Sbjct: 185  HLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALH 244

Query: 473  LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM-VALLLGQGANINAQTE 531
            +A   G   +A  L+  GA++ + ND+G+TPL  AA   +  + + LL+  GA++N Q++
Sbjct: 245  IACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSK 304

Query: 532  ETQETALTLACCGGFLEVADFLIKAGADIELGC---STPLMEAAQEGHLELV-------- 580
            E + + L +A   G    +  LI+ G++I+      +TPL  AA+ GH  L+        
Sbjct: 305  EGK-SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363

Query: 581  -------------------------------------------KYLLAAGANVHATTATG 597
                                                       +++L+AG +++     G
Sbjct: 364  DTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLG 423

Query: 598  DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
             T L  A   G+ +  ++LL +GADL    + GRTPL  AA  G       L++ GA VN
Sbjct: 424  RTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVN 483

Query: 658  RT-----------TANNDHTVLSLACAGGHLA----------------VVELLLAHGADP 690
                          A++ +          H A                 +E LL +GADP
Sbjct: 484  EADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADP 543

Query: 691  THRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQ 750
            + R + G T +  AA  G+   +  LL+   N L     DV    P S     A     +
Sbjct: 544  SLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLE----DVESTIPVSPLHLAAYNGHCE 599

Query: 751  ALPMVVPPQEPDKPPANVATTLPIRNK---------AVSGRASAMSNTPTHSIAASISQP 801
            AL          K  A     L +R+             G    +     H  +A I + 
Sbjct: 600  AL----------KTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKER 649

Query: 802  QTP-TPSPIISPSA-------MLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLE 853
            +   TP    + S        ++      DI    ++   T L LA   GH + V  LLE
Sbjct: 650  KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLE 709

Query: 854  RGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQE 913
            +G++ +  D +G T L   A  G    +  LLD+ A +  +  + + TP+ LA + G   
Sbjct: 710  KGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGR-TPIHLASACGHTA 768

Query: 914  VVELLLARGANKEHRNV----SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS 969
            V+  LL    + +  +     S Y+P+  A+  G+ + +++LL   +  +   G+    +
Sbjct: 769  VLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNP--FT 825

Query: 970  PLMLAAMNGHTAAVKLLLD-MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1028
            PL  A +N   +  ++LL  +G+ I    +    T L  A F      + +LL  +A V 
Sbjct: 826  PLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN 885

Query: 1029 HRAKTGLTPLMEAASGGYAEVGRVLLDKG-ADVNAPPVPSSRDTALTIAADKGHYKFCEL 1087
                TG T LM AA  G       LL +G AD+    +  +++TAL +A  KGH K C L
Sbjct: 886  ATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTV--LDENKNTALHLACSKGHEK-CAL 942

Query: 1088 LIGRGAH----IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMA-A 1142
            +I         I+  N     PL +AA  G   VVQ L+  GA V A D    TP +A A
Sbjct: 943  MILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002

Query: 1143 FRKGHVKVVRYLVKEVNQFP 1162
              K     +  ++  +  FP
Sbjct: 1003 PNKDVADCLALILSTMKPFP 1022



 Score =  181 bits (458), Expect = 1e-44
 Identities = 233/855 (27%), Positives = 350/855 (40%), Gaps = 97/855 (11%)

Query: 228  ANAGQSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQ 284
            A+ G  D +    L  A + G +  V+ LL  G  ++E    G + L +AC  G   +A 
Sbjct: 197  ADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAI 256

Query: 285  VLLAMHANVEDRGIKGDITPL-MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACA 343
             L+   ANV     KG  TPL +AA +      ++LL+ + ADVN QS  G + L  A  
Sbjct: 257  ELVNAGANVNQPNDKG-FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAI 315

Query: 344  GGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKES 403
             G     ++L+++G+ I+  ++ G+TPL  A   GH  +   L+ NGA            
Sbjct: 316  HGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD-TARRGIHDMF 374

Query: 404  ALTLACYKGHLEMVRFLLEAG--------ADQEH---------KTDEM-HTALMEACMDG 445
             L LA   G  +  R LL +G           EH           D +  T L  A   G
Sbjct: 375  PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434

Query: 446  HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLM 505
            +VE   LLL SGA +        +PL  AA  G  + A  L+  GA + E + +G +PL 
Sbjct: 435  NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494

Query: 506  EAA-------REGH-------EE--------------MVALLLGQGANINAQTEETQETA 537
             AA        E H       EE               +  LL  GA+ + +  +   TA
Sbjct: 495  YAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGY-TA 553

Query: 538  LTLACCGGFLEVADFLIKAG----ADIELGCS-TPLMEAAQEGHLELVKYLLAAGANVHA 592
            +  A   G  +  + L++       D+E     +PL  AA  GH E +K L     N+  
Sbjct: 554  VHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDV 613

Query: 593  TTATGDTALTYACENGHTDVADVLLQAGAD-LEHESEGGRTPLMKAARAGHVCTVQFLIS 651
                G TAL  A E G T+  +VL   GA  L  E +   TPL  AA +GH  ++  LI 
Sbjct: 614  RDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLID 673

Query: 652  KGANVNRTTANNDH--TVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH 709
             G   + T   + +  T L LA   GH+  V LLL  G+        G T L   A  G 
Sbjct: 674  SGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGC 733

Query: 710  TSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVA 769
               +  LLD+   +L     D    TP            ++ L       +P     + +
Sbjct: 734  EDCLAALLDHDAFVLCR---DFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYS 790

Query: 770  TTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTE 829
               P+   + +G    +     HS            P   +  +   P++ A+ I+ Q  
Sbjct: 791  GYSPMHWASYTGHEDCLELLLEHS------------PFSYLEGNPFTPLHCAV-INNQDS 837

Query: 830  SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
            +   T + L   G               +  RD KG TPL  AA A +V  + +LL + A
Sbjct: 838  T---TEMLLGALG------------AKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQA 882

Query: 890  DIEAQSERTKDTPLSLACSGGRQEVVELLLARG-ANKEHRNVSDYTPLSLAASGGYVNII 948
            ++ A ++ T  T L  A   G+   VE LL RG A+    + +  T L LA S G+    
Sbjct: 883  EVNA-TDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCA 941

Query: 949  KILLNAGAEIN--SRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALT 1006
             ++L    ++   + T S L + PL +AA NG  + V+ LL  G+ + A  E     AL 
Sbjct: 942  LMILAETQDLGLINATNSALQM-PLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALA 1000

Query: 1007 LACFQGRTEVVSLLL 1021
             A  +   + ++L+L
Sbjct: 1001 CAPNKDVADCLALIL 1015



 Score =  105 bits (261), Expect = 7e-22
 Identities = 120/418 (28%), Positives = 172/418 (41%), Gaps = 36/418 (8%)

Query: 224  AESTANAGQSDNR---SLAEACSEGDVNAVRKLLIEGRS--VNEHTEEGESLLCLACSAG 278
            AE+  N    D++   +L  A   G    V  L   G S  + E   +   L   A S G
Sbjct: 605  AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS-G 663

Query: 279  YYELAQVLLAMHANVEDRGIKGDIT---------PLMAAANGGHVKIVKLLLAHKADVNA 329
            + +   +L+       D G + DIT         PLM A   GHV  V LLL   +  +A
Sbjct: 664  HTDSLHLLI-------DSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADA 716

Query: 330  QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389
                G TAL      G  D +  LL+  A +   +  G TP+  A + GH  V R LL+ 
Sbjct: 717  ADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQA 776

Query: 390  GAG---INTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH 446
                  ++   +    S +  A Y GH + +  LLE  +   +      T L  A ++  
Sbjct: 777  ALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQ 835

Query: 447  VEVARLLLDS-GAQ-VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL 504
                 +LL + GA+ VN       +PL  AA   +V    +L++  A +   +  G T L
Sbjct: 836  DSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 895

Query: 505  MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC 564
            M AA  G    V  LL +G       +E + TAL LAC  G  + A  ++    D+ L  
Sbjct: 896  MTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLIN 955

Query: 565  ST------PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616
            +T      PL  AA+ G   +V+ LL+ GA V A    G T       N   DVAD L
Sbjct: 956  ATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN--KDVADCL 1011



 Score = 93.2 bits (230), Expect = 3e-18
 Identities = 87/273 (31%), Positives = 134/273 (49%), Gaps = 15/273 (5%)

Query: 898  TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY---TPLSLAASGGYVNIIKILLNA 954
            T   PL  A      E V  LL++   KE+ NV D    TPL  AA  G V I+++LL +
Sbjct: 7    TDQPPLVQAIFSRDVEEVRSLLSQ---KENINVLDQERRTPLHAAAYVGDVPILQLLLMS 63

Query: 955  GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1014
            GA +N++    L ++PL  AA + +   + LLL   +D+NA+ +    T L +A     T
Sbjct: 64   GANVNAK--DTLWLTPLHRAAASRNEKVLGLLLAHSADVNAR-DKLWQTPLHVAAANRAT 120

Query: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1074
            +    L    +++    ++G + L  A   G+ E   +LL+KGA +N           L 
Sbjct: 121  KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV--CDKKERQPLH 178

Query: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1134
             AA  GH +  +LL+ RGA +  +++KG   L  AA  G ++VV+ L++ GA++D  +  
Sbjct: 179  WAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAF 238

Query: 1135 KITPLMAAFRKGHVKVVRYLVK---EVNQFPSD 1164
              T L  A   G   V   LV     VNQ P+D
Sbjct: 239  GNTALHIACYLGQDAVAIELVNAGANVNQ-PND 270



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 74/228 (32%), Positives = 113/228 (49%), Gaps = 5/228 (2%)

Query: 929  NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD 988
            +++D  PL  A     V  ++ LL+    IN     +   +PL  AA  G    ++LLL 
Sbjct: 5    SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERR--TPLHAAAYVGDVPILQLLLM 62

Query: 989  MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1048
             G+++NA+ +T   T L  A      +V+ LLL   A+V  R K   TPL  AA+    +
Sbjct: 63   SGANVNAK-DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATK 121

Query: 1049 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWL 1108
                L    + +N      S  +AL  A   GH +   LL+ +GA ++V +KK   PL  
Sbjct: 122  CAEALAPLLSSLNV--ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHW 179

Query: 1109 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
            AA  GHL+V++LLV  GAD+   D +    L  A   G ++VV+YL++
Sbjct: 180  AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 58/177 (32%), Positives = 83/177 (46%), Gaps = 4/177 (2%)

Query: 293  VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352
            V  R  KG  TPL AAA   +V  +++LL H+A+VNA   TG TAL  A   G    V+ 
Sbjct: 851  VNSRDAKGR-TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909

Query: 353  LLESG-ASIEDHNENGHTPLMEAGSAGHVEVARLLLEN--GAGINTHSNEFKESALTLAC 409
            LL  G A +   +EN +T L  A S GH + A ++L      G+   +N   +  L +A 
Sbjct: 910  LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969

Query: 410  YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466
              G   +V+ LL  GA      +E HT  +    +  V     L+ S  +   P D+
Sbjct: 970  RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  256 bits (653), Expect = 2e-67
 Identities = 209/691 (30%), Positives = 315/691 (45%), Gaps = 97/691 (14%)

Query: 131  EVESFILD--QDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLS 188
            E + F L     +L+    E A  ++ +GT     L T+ P+ Q  L+ L++A     ++
Sbjct: 451  EAQEFALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA--HVN 508

Query: 189  TADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSL-AEACSEGDV 247
            + D           R +  V  AL+   +  T +   ++ N   S+ R+L A A   G +
Sbjct: 509  SEDD----------RTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSL 558

Query: 248  NAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR----------- 296
            + V  L+  G  +      G + L LA   G+ ++   L+   AN+              
Sbjct: 559  DVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSA 618

Query: 297  ---------------GIKGDI------TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGN 335
                           G+K D       T L AAA GGH  IV  LL H A+VN   + G 
Sbjct: 619  AWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR 678

Query: 336  TALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAG-----SAGHVEVARLLLENG 390
            TAL  A   G+ ++V+ LL+ GA +   + +G T L  A      S GH  V  LL++ G
Sbjct: 679  TALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRG 738

Query: 391  AGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH---- 446
            A ++ H ++   + L +A Y+GH+++V  LLE GAD +H  +   T L+ A   GH    
Sbjct: 739  AEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVV 797

Query: 447  -----------------------------VEVARLLLDSGAQVNMPADSFESPLTLAACG 477
                                         VEV R LLD G   N   D+  +PL +AA  
Sbjct: 798  NTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFE 857

Query: 478  GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETA 537
            GH  +   LIE+GA   E++++G  P + A++EGH + V +LL   +NI+ +  + +  A
Sbjct: 858  GHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRN-A 916

Query: 538  LTLACCGGFLEVADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATT 594
            L +A   G  ++ + L   GAD+   +      L   A E  L + +Y L  GANV A+ 
Sbjct: 917  LRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASD 976

Query: 595  ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGA 654
            A G TAL  +C  GH ++  VL+   AD+       R+ L  AA  GHV  VQ LI  GA
Sbjct: 977  AEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGA 1036

Query: 655  NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
             V+ T  N   T L +A   GH+ VV++LL HGADP H  + G T +  AAK GH+ ++ 
Sbjct: 1037 VVDHT-CNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIK 1095

Query: 715  YLLDYPNNLLSAPPPDVTQLTPPSHDLNRAP 745
             L  Y  + L+   P       P H + + P
Sbjct: 1096 LLEKYGASSLNGCSPS------PVHTMEQKP 1120



 Score =  246 bits (628), Expect = 2e-64
 Identities = 210/644 (32%), Positives = 309/644 (47%), Gaps = 74/644 (11%)

Query: 548  EVADFLIKAGADI--ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYAC 605
            EV   L+KAGA +  E   ++ ++  A E   + ++ LL  GA+V+   + G T L  A 
Sbjct: 495  EVLQLLVKAGAHVNSEDDRTSCIVRQALERE-DSIRTLLDNGASVNQCDSNGRTLLANAA 553

Query: 606  ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDH 665
             +G  DV ++L+  GADLE E   G TPL  AAR GH   V  LI  GAN+N T  +   
Sbjct: 554  YSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG-W 612

Query: 666  TVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLS 725
            T L  A  GGH  VV  LL  G        D  T L  AA GGH  +V  LL +   +  
Sbjct: 613  TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672

Query: 726  APPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASA 785
            A     T L   ++      R  V+ L               +     + ++ V GR +A
Sbjct: 673  ADNEGRTALIAAAY---MGHREIVEHL---------------LDHGAEVNHEDVDGR-TA 713

Query: 786  MSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHE 845
            +S        A++  P +   + ++S    L I    ++D   + +  T L +A   GH 
Sbjct: 714  LS-------VAALCVPASKGHASVVS----LLIDRGAEVD-HCDKDGMTPLLVAAYEGHV 761

Query: 846  ELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSL 905
            ++V  LLE GA ++H D  G TPL+ AA+ GH  VV  LL  GA +++     + T LS+
Sbjct: 762  DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-TVLSI 820

Query: 906  ACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSK 965
            A + G  EVV  LL RG ++ HR+ + +TPL +AA  G+  I + L+  GA  N      
Sbjct: 821  ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND- 879

Query: 966  LGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL----- 1020
             G  P +LA+  GH   V++LL+  S+I+ +    RN AL +A  +G  ++V LL     
Sbjct: 880  -GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRN-ALRVAALEGHRDIVELLFSHGA 937

Query: 1021 ----------------------------LDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1052
                                        L+  ANVE     G T L  +   G+ E+ +V
Sbjct: 938  DVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQV 997

Query: 1053 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANG 1112
            L+   ADVNA    + + +AL  AA +GH K  +LLI  GA +D    +G T L +AA  
Sbjct: 998  LIAYHADVNA--ADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQE 1055

Query: 1113 GHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
            GH+DVVQ+L++ GAD + AD    T +  A + GH ++++ L K
Sbjct: 1056 GHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEK 1099



 Score =  244 bits (624), Expect = 6e-64
 Identities = 201/654 (30%), Positives = 312/654 (47%), Gaps = 54/654 (8%)

Query: 481  ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
            E+  LL++ GA +   +D     + +A     E+ +  LL  GA++N Q +    T L  
Sbjct: 495  EVLQLLVKAGAHVNSEDDRTSCIVRQALER--EDSIRTLLDNGASVN-QCDSNGRTLLAN 551

Query: 541  ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
            A   G L+V + L+  GAD+E+  +   TPL  AA++GH ++V  L+  GAN++ T   G
Sbjct: 552  AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611

Query: 598  DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
             TAL  A   GHT+V   LL AG  ++      RT L  AA  GH   V  L+  GA VN
Sbjct: 612  WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671

Query: 658  RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA-----KGGHTSV 712
            +   N   T L  A   GH  +VE LL HGA+  H   DG T L  AA       GH SV
Sbjct: 672  KAD-NEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASV 730

Query: 713  VCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTL 772
            V  L+D    +       +T L   +++      V V  L ++    + D    N  T  
Sbjct: 731  VSLLIDRGAEVDHCDKDGMTPLLVAAYE----GHVDVVDL-LLEGGADVDHTDNNGRT-- 783

Query: 773  PIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNH 832
            P+   A  G AS ++                           +L    A+D     +S  
Sbjct: 784  PLLAAASMGHASVVNT--------------------------LLFWGAAVD---SIDSEG 814

Query: 833  DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 892
             T L++A A G+ E+V+TLL+RG    HRD  G+TPL +AA  GH  + E L++ GA   
Sbjct: 815  RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874

Query: 893  AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 952
             + +     P  LA   G  + V++LL   +N + R       L +AA  G+ +I+++L 
Sbjct: 875  -EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLF 933

Query: 953  NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012
            + GA++N +     G   L + A+       +  L+ G+++ A     R TAL ++C+QG
Sbjct: 934  SHGADVNCKDAD--GRPTLYILALENQLTMAEYFLENGANVEASDAEGR-TALHVSCWQG 990

Query: 1013 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1072
              E+V +L+   A+V        + L  AA  G+ +V ++L++ GA V+     +   TA
Sbjct: 991  HMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH--TCNQGATA 1048

Query: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1126
            L IAA +GH    ++L+  GA  +  ++ G T + +AA  GH  +++LL + GA
Sbjct: 1049 LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102



 Score =  176 bits (445), Expect = 3e-43
 Identities = 119/314 (37%), Positives = 163/314 (51%), Gaps = 9/314 (2%)

Query: 845  EELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLS 904
            +E++Q L++ GA +   D +  T  I+         +  LLDNGA +  Q +    T L+
Sbjct: 494  QEVLQLLVKAGAHVNSEDDR--TSCIVRQALEREDSIRTLLDNGASVN-QCDSNGRTLLA 550

Query: 905  LACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGS 964
             A   G  +VV LL++RGA+ E  +   +TPL+LAA  G+  ++  L+  GA IN     
Sbjct: 551  NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610

Query: 965  KLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRK 1024
              G + L  AA  GHT  V  LL  G  ++   + +  TAL  A + G  ++V  LL   
Sbjct: 611  --GWTALRSAAWGGHTEVVSALLYAGVKVDCA-DADSRTALRAAAWGGHEDIVLNLLQHG 667

Query: 1025 ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD---TALTIAADKGH 1081
            A V      G T L+ AA  G+ E+   LLD GA+VN   V         AL + A KGH
Sbjct: 668  AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727

Query: 1082 YKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMA 1141
                 LLI RGA +D  +K G TPL +AA  GH+DVV LL++ GADVD  DN   TPL+A
Sbjct: 728  ASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787

Query: 1142 AFRKGHVKVVRYLV 1155
            A   GH  VV  L+
Sbjct: 788  AASMGHASVVNTLL 801



 Score =  175 bits (444), Expect = 4e-43
 Identities = 123/336 (36%), Positives = 180/336 (53%), Gaps = 11/336 (3%)

Query: 827  QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886
            Q +SN  T L  A   G  ++V  L+ RGA +E  D  G TPL LAA  GH  VV  L+ 
Sbjct: 540  QCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIG 599

Query: 887  NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVN 946
             GA+I   +++   T L  A  GG  EVV  LL  G   +  +    T L  AA GG+ +
Sbjct: 600  CGANIN-HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHED 658

Query: 947  IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALT 1006
            I+  LL  GAE+N       G + L+ AA  GH   V+ LLD G+++N + + +  TAL+
Sbjct: 659  IVLNLLQHGAEVNKADNE--GRTALIAAAYMGHREIVEHLLDHGAEVNHE-DVDGRTALS 715

Query: 1007 LACF-----QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061
            +A       +G   VVSLL+DR A V+H  K G+TPL+ AA  G+ +V  +LL+ GADV+
Sbjct: 716  VAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD 775

Query: 1062 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
                 ++  T L  AA  GH      L+  GA +D  + +G T L +A+  G+++VV+ L
Sbjct: 776  H--TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833

Query: 1122 VQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
            +  G D +  D+   TPL  A  +GH  +   L+++
Sbjct: 834  LDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869



 Score =  159 bits (401), Expect = 4e-38
 Identities = 118/380 (31%), Positives = 182/380 (47%), Gaps = 9/380 (2%)

Query: 225  ESTANAGQSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYE 281
            E  A+   +DN     L  A S G  + V  LL  G +V+    EG ++L +A + G  E
Sbjct: 769  EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVE 828

Query: 282  LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
            + + LL    +   R   G  TPL  AA  GH  I + L+   A  N   + G      A
Sbjct: 829  VVRTLLDRGLDENHRDDAG-WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILA 887

Query: 342  CAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401
               G+ D V++LLE+ ++I+    +G   L  A   GH ++  LL  +GA +N    + +
Sbjct: 888  SQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGR 947

Query: 402  ESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 461
             +   LA  +  L M  + LE GA+ E    E  TAL  +C  GH+E+ ++L+   A VN
Sbjct: 948  PTLYILAL-ENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVN 1006

Query: 462  MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG 521
               +   S L  AA  GHV++  LLIE GA ++   ++G T L  AA+EGH ++V +LL 
Sbjct: 1007 AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLE 1066

Query: 522  QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVK 581
             GA+ N   ++   TA+ +A   G  ++   L K GA    GCS   +   ++  L+ + 
Sbjct: 1067 HGADPN-HADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLS 1125

Query: 582  ---YLLAAGANVHATTATGD 598
                 L   +N   +T  GD
Sbjct: 1126 SKVQSLTIKSNSSGSTGGGD 1145



 Score = 40.4 bits (93), Expect = 0.021
 Identities = 51/196 (26%), Positives = 81/196 (41%), Gaps = 13/196 (6%)

Query: 1680 PLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSS-ASTVPGTSTNGSP 1738
            P  P  A +SP          Q SS S  +   S  SS  TT+S++ A TVP  S +   
Sbjct: 1154 PNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHNLS 1213

Query: 1739 SSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPP 1798
             +  +++      +  S +  + V+ +++   T     ++  P+++  +    PS  S  
Sbjct: 1214 FTEQIQQHS----LPRSRSRQSIVSPSST---TQSLGQSHNSPSSEFEWSQVKPSLKSTK 1266

Query: 1799 AQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQ 1858
            A  GG S NS    GSA      S+S Q    P V+E   T+       + S +A   +Q
Sbjct: 1267 ASKGGKSENS-AKSGSAGKKAKQSNSSQ----PKVLEYEMTQFDRRGPIAKSGTAAPPKQ 1321

Query: 1859 QPPGSVSQEPRPPLQQ 1874
             P  S  +   P  QQ
Sbjct: 1322 MPAESQCKIMIPSAQQ 1337


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  246 bits (629), Expect = 1e-64
 Identities = 254/907 (28%), Positives = 394/907 (43%), Gaps = 58/907 (6%)

Query: 226  STANAGQSDNRSLA---EACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYEL 282
            S A     DN  L     A +     AV+ L+     VN   +  ++ L +A +    + 
Sbjct: 38   SGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKC 97

Query: 283  AQVLLAM--HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340
            A+V++ +    NV DRG +   T L  AA  GHV++V LLLA  A++NA       AL +
Sbjct: 98   AEVIIPLLSSVNVSDRGGR---TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHW 154

Query: 341  ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400
            A   G++DVV +L+  GA +   ++ G+TPL  A S G + V + LL  G  I+   N +
Sbjct: 155  AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVY 213

Query: 401  KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQ 459
              +AL +ACY G   +V  L++ GA+     +   T L  A    H  +   LL+++GA 
Sbjct: 214  GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD 273

Query: 460  VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALL 519
            VN+ +   +SPL + A  G    +  LI+ G  ++ V+ +G TPL  AAR GHE ++  L
Sbjct: 274  VNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTL 333

Query: 520  LGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGH 576
               GA+  A+        L LA      +    L+ +G +I+       T L  AA  G+
Sbjct: 334  RTSGAD-TAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGN 392

Query: 577  LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
            +E +K L ++GA+ H     G T L YA  N H    + L+  GA++    + GRT L  
Sbjct: 393  VECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHY 452

Query: 637  AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLA------VVELLLAHGADP 690
            AA            +   + N+T   N H           L        +E LL + A+P
Sbjct: 453  AA------------ASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANP 500

Query: 691  THRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSH-----DLNRAP 745
            + R K+G   +  AA  GH   +  LL+  N+         T+   P H       ++A 
Sbjct: 501  SIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK--SPLHLAAYNGHHQAL 558

Query: 746  RVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPT 805
             V +Q+L  +    E  +   ++A       K  +    A+ N             +TP 
Sbjct: 559  EVLLQSLVDLDIRDEKGRTALDLAAF-----KGHTECVEALINPGASIFVKDNVTKRTPL 613

Query: 806  PSPIISPSAM-----LPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEH 860
             + +I+   +     L I    +     ++   T L LA A GH + V  LLE+ A+++ 
Sbjct: 614  HASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDT 673

Query: 861  RDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLA 920
             D  G T L      GH   V++LL+    I  +  R + TPL  A + G    +  LL 
Sbjct: 674  VDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGR-TPLHYAAARGHATWLSELLQ 732

Query: 921  RGANKE---HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 977
               ++E    ++   YTPL  A   G  N I++LL          G+    +PL  A +N
Sbjct: 733  MALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC-FRKFIGNP--FTPLHCAIIN 789

Query: 978  GHTAAVKLLLD-MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLT 1036
             H     LLL  + S I +  +    T L  A F    E + LLL   A V     +G T
Sbjct: 790  DHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKT 849

Query: 1037 PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHID 1096
             LM AA  G A    +L++  A  +        +T L +A  KGH K   L++ +     
Sbjct: 850  ALMMAAENGQAGAVDILVN-SAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDES 908

Query: 1097 VRNKKGN 1103
            + N+K N
Sbjct: 909  LINEKNN 915



 Score =  224 bits (570), Expect = 1e-57
 Identities = 258/959 (26%), Positives = 410/959 (42%), Gaps = 108/959 (11%)

Query: 320  LLAHKA-DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAG 378
            +L HK  DVN   S   T L  A   G  +++++L+ SGA +   +    TPL  A ++ 
Sbjct: 1    MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 379  HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL 438
              E  ++L+++ A +N     + ++ L +A     ++    ++   +          TAL
Sbjct: 61   SEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119

Query: 439  MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND 498
              A ++GHVE+  LLL  GA +N         L  AA  GH+++ ALLI  GA +   + 
Sbjct: 120  HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179

Query: 499  EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 558
            +GYTPL  AA  G   +V  LL  G  I+ +      TAL +AC  G   V + LI  GA
Sbjct: 180  KGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGA 238

Query: 559  DIELGCS---TPLMEAAQEGHLEL-VKYLLAAGANVHATTATGDTALTYACENGHTDVAD 614
            ++    +   TPL  AA   H  L ++ L+  GA+V+  +  G + L     +G    + 
Sbjct: 239  NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298

Query: 615  VLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAG 674
             L+Q G +++   + G TPL  AAR GH   +  L + GA+  +   ++    L LA   
Sbjct: 299  TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP-LHLAALN 357

Query: 675  GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQL 734
             H      LL+ G +     K G T L  AA GG+   +         LL +   D    
Sbjct: 358  AHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECI--------KLLQSSGADF--- 406

Query: 735  TPPSHDLNRAPRVPV---------QALPMVVPPQEPDKPPANVATTLPIRNKAVS-GRAS 784
                H  ++  R P+           +  +V         ANV  T      A+    AS
Sbjct: 407  ----HKKDKCGRTPLHYAAANCHFHCIETLV------TTGANVNETDDWGRTALHYAAAS 456

Query: 785  AMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQ---TESNHDTALTLACA 841
             M    T    A  +  +      +    A L +   +  DA     +     ++  A A
Sbjct: 457  DMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAA 516

Query: 842  GGHEELVQTLLERGASIEHRDKKGFT--PLILAATAGHVGVVEILLDNGADIEAQSERTK 899
             GH + ++ LLER  S       G T  PL LAA  GH   +E+LL +  D++ + E+ +
Sbjct: 517  YGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGR 576

Query: 900  DTPLSLACSGGRQEVVELLLARGANKEHR-NVSDYTPLSLAASGGYVNIIKILLNAGAEI 958
             T L LA   G  E VE L+  GA+   + NV+  TPL  +   G+   +++LL      
Sbjct: 577  -TALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNP 635

Query: 959  NS-RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1017
             +       G +PLMLA   GH  AV LLL+  ++++  ++    TAL      G  E V
Sbjct: 636  EAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDT-VDILGCTALHRGIMTGHEECV 694

Query: 1018 SLLLDRKANVEHRAKTGLTPLMEAASGGYA----EVGRVLLDK----------------- 1056
             +LL+++ ++  +   G TPL  AA+ G+A    E+ ++ L +                 
Sbjct: 695  QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754

Query: 1057 --GADVNAPPVPSSRD----------TALTIAADKGHYKFCELLIGR--GAHIDVRNKKG 1102
                + N   V   +           T L  A    H     LL+G    + +  R+ KG
Sbjct: 755  CYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKG 814

Query: 1103 NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFP 1162
             TPL  AA   H++ +QLL++  A V+A DN   T LM A   G    V  L   VN   
Sbjct: 815  RTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL---VNSAQ 871

Query: 1163 SDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREES 1221
            +D        T+ DK++    HL             ++ ++  ++L+    L+K+++ES
Sbjct: 872  AD-------LTVKDKDLNTPLHLA-----------CSKGHEKCALLI----LDKIQDES 908



 Score =  194 bits (494), Expect = 7e-49
 Identities = 244/922 (26%), Positives = 363/922 (39%), Gaps = 140/922 (15%)

Query: 114 NNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGA-DLRTVDPETQ 172
           + +E+    D E+     V +F+ D + +E         L+LSG    A D   + P  +
Sbjct: 4   HKTEDVNTLDSEKRTPLHVAAFLGDAEIIE--------LLILSGARVNAKDNMWLTPLHR 55

Query: 173 ARLEALLEAAGIGKLSTAD----GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTA 228
           A      EA  +    +AD     K +  P  +     +V CA  E    L      S+ 
Sbjct: 56  AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCA--EVIIPLL-----SSV 108

Query: 229 NAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287
           N      R+ L  A   G V  V  LL +G ++N   ++    L  A   G+ ++  +L+
Sbjct: 109 NVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLI 168

Query: 288 AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYV 347
              A V  +  KG  TPL AAA+ G + +VK LL    +++  +  GNTAL  AC  G  
Sbjct: 169 NHGAEVTCKDKKG-YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQD 227

Query: 348 DVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVA-RLLLENGAGINTHSNEFKE---- 402
            VV  L++ GA++   N NG TPL  A ++ H  +   LL+ NGA +N  S + K     
Sbjct: 228 AVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHM 287

Query: 403 ----------------------------SALTLACYKGHLEMVRFLLEAGADQEHKTDEM 434
                                       + L +A   GH  ++  L  +GAD        
Sbjct: 288 TAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHS 347

Query: 435 HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLE 494
              L  A ++ H +  R LL SG +++ P     + L  AA GG+VE   LL   GA   
Sbjct: 348 MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407

Query: 495 EVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGF-------- 546
           + +  G TPL  AA   H   +  L+  GAN+N +T++   TAL  A             
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILG 466

Query: 547 --------LEVA------------DFLIKAGADIELGCS---TPLMEAAQEGHLELVKYL 583
                   LE A            +FL++  A+  +        +  AA  GH + ++ L
Sbjct: 467 NAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELL 526

Query: 584 LAAGANVHATTATGDTA--LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 641
           L    +    + +G T   L  A  NGH    +VLLQ+  DL+   E GRT L  AA  G
Sbjct: 527 LERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKG 586

Query: 642 HVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP-THRLKD--GS 698
           H   V+ LI+ GA++         T L  +   GH   + LLL    +P    +KD  G 
Sbjct: 587 HTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQ 646

Query: 699 TMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPP 758
           T L+ A   GH   V  LL+   N+ +    D+   T     L+R      +    ++  
Sbjct: 647 TPLMLAVAYGHIDAVSLLLEKEANVDTV---DILGCTA----LHRGIMTGHEECVQMLLE 699

Query: 759 QEPDKPPANVATTLPIRNKAVSGRASAMSN-------------------TPTH------- 792
           QE      +     P+   A  G A+ +S                    TP H       
Sbjct: 700 QEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGN 759

Query: 793 -----------SIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHD----TALT 837
                           I  P TP    II+            ID+   S  D    T L 
Sbjct: 760 ENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLR 819

Query: 838 LACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 897
            A    H E +Q LL   A +   D  G T L++AA  G  G V+IL+++        ++
Sbjct: 820 AAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDK 879

Query: 898 TKDTPLSLACSGGRQEVVELLL 919
             +TPL LACS G ++   L+L
Sbjct: 880 DLNTPLHLACSKGHEKCALLIL 901



 Score =  137 bits (345), Expect = 1e-31
 Identities = 154/572 (26%), Positives = 232/572 (40%), Gaps = 77/572 (13%)

Query: 221 RMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYY 280
           R     TA  G      L  A      +  RKLL  G  ++   + G + L  A + G  
Sbjct: 334 RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNV 393

Query: 281 ELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340
           E  ++L +  A+   +   G  TPL  AA   H   ++ L+   A+VN     G TAL Y
Sbjct: 394 ECIKLLQSSGADFHKKDKCGR-TPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHY 452

Query: 341 ACA----------GGYVD------------------VVKVLLESGASIEDHNENGHTPLM 372
           A A          G   D                   ++ LL++ A+    ++ G+  + 
Sbjct: 453 AAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIH 512

Query: 373 EAGSAGHVEVARLLLEN-GAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKT 431
            A + GH +   LLLE   +G     +   +S L LA Y GH + +  LL++  D + + 
Sbjct: 513 YAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRD 572

Query: 432 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHVELAALLIERG 490
           ++  TAL  A   GH E    L++ GA + +  + +  +PL  +   GH     LL+E  
Sbjct: 573 EKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIA 632

Query: 491 ASLEEVN---DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
            + E V+    +G TPLM A   GH + V+LLL + AN++   +    TAL      G  
Sbjct: 633 DNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDT-VDILGCTALHRGIMTGHE 691

Query: 548 EVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTAT---GDTAL 601
           E    L++    I    S   TPL  AA  GH   +  LL    +          G T L
Sbjct: 692 ECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPL 751

Query: 602 TYACENGHTDVADVLLQA----------------------------------GADLEHES 627
            +AC NG+ +  +VLL+                                    + +    
Sbjct: 752 HWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRD 811

Query: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL-AH 686
           + GRTPL  AA A HV  +Q L+   A VN    N+  T L +A   G    V++L+ + 
Sbjct: 812 DKGRTPLRAAAFADHVECLQLLLRHSAPVN-AVDNSGKTALMMAAENGQAGAVDILVNSA 870

Query: 687 GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
            AD T + KD +T L  A   GH      +LD
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILD 902



 Score = 52.0 bits (123), Expect = 7e-06
 Identities = 68/268 (25%), Positives = 100/268 (37%), Gaps = 72/268 (26%)

Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
           A + G ++AV  LL +  +V+     G + L      G+ E  Q+LL    ++  +  +G
Sbjct: 652 AVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRG 711

Query: 301 DITPLMAAANGGHVKIVKLLLA---HKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
             TPL  AA  GH   +  LL     + D   + + G T L +AC  G  + ++VLLE  
Sbjct: 712 R-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQK 770

Query: 358 ---------------ASIEDH-------------------NENGHTPLMEAGSAGHVEVA 383
                          A I DH                   ++ G TPL  A  A HVE  
Sbjct: 771 CFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECL 830

Query: 384 RLLLENGAGINTHSNEFK---------------------------------ESALTLACY 410
           +LLL + A +N   N  K                                  + L LAC 
Sbjct: 831 QLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACS 890

Query: 411 KGHLEMVRFLLEAGADQEHKTDEMHTAL 438
           KGH +    +L+   D E   +E + AL
Sbjct: 891 KGHEKCALLILDKIQD-ESLINEKNNAL 917


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase [Homo sapiens]
          Length = 1327

 Score =  209 bits (531), Expect = 3e-53
 Identities = 243/860 (28%), Positives = 355/860 (41%), Gaps = 116/860 (13%)

Query: 298  IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTG--NTALTYACAGGYVDVVKVLLE 355
            + G +  L+ A   G V  VK L+   A+VNA+   G  ++ L +A   G  DVV+ LL+
Sbjct: 179  VSGALRELLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQ 237

Query: 356  SGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLE 415
             GA++   ++ G  PL  A                                  C  GH E
Sbjct: 238  MGANVHARDDGGLIPLHNA----------------------------------CSFGHAE 263

Query: 416  MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 475
            +V  LL  GAD   + +  +T L EA + G ++V  +LL  GA  N+     +S L LA 
Sbjct: 264  VVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLAD 323

Query: 476  CGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEE-MVALLLGQGANINAQTEETQ 534
                  L           E   DE    L+EAAR G+EE ++ALL     N +A ++  +
Sbjct: 324  PSAKAVLTG---------EYKKDE----LLEAARSGNEEKLMALLTPLNVNCHA-SDGRK 369

Query: 535  ETALTLACCGGFLEVADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVH 591
             T L LA     + +   L++ GAD+   + G   PL  A   GH E+ + LL  GA V+
Sbjct: 370  STPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVN 429

Query: 592  ATTATGDTALTYACENGHTDVADVLLQAGAD-----------------------LEHESE 628
            A      T L  A      +V  +LL  GAD                       L +E +
Sbjct: 430  AMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFK 489

Query: 629  GGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGH---LAVVELLLA 685
            G    L++AAR   +  V+  ++    +N     +  T L  A A  H     V ELLL 
Sbjct: 490  GHS--LLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLHPKRKQVTELLLR 546

Query: 686  HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAP 745
             GA+   + KD  T L  AA+  H  V+  L  +   + +      T L    H    A 
Sbjct: 547  KGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTAL----HRAALAG 602

Query: 746  RVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPT 805
             +    L ++    +P        T   + N+AV    S  +   T  +   + +     
Sbjct: 603  HLQTCRL-LLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAG 661

Query: 806  PSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKG 865
                +            D+    E  H T L  A       +V+ LL  GA +  +DK G
Sbjct: 662  DLETVKQLCSSQNVNCRDL----EGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGG 717

Query: 866  FTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANK 925
              PL  A + GH  V E+L+ +GA +   ++  K TPL  A + G+ E+ +LLL  GA+ 
Sbjct: 718  LVPLHNACSYGHYEVAELLVRHGASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADP 776

Query: 926  EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKL 985
              +N    TPL L   G     I+ LL              G + L+ AA  G  A V+ 
Sbjct: 777  TKKNRDGNTPLDLVKEGD--TDIQDLLR-------------GDAALLDAAKKGCLARVQK 821

Query: 986  LLDMGSDINAQIETNRN-TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASG 1044
            L     +IN +    RN T L LA      EV   LL+  A+V  + K GL PL  AAS 
Sbjct: 822  LCTP-ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASY 880

Query: 1045 GYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNT 1104
            G+ ++  +L+     VNA        T L  AA KG  + C LL+  GA   ++N++G T
Sbjct: 881  GHVDIAALLIKYNTCVNA--TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQT 938

Query: 1105 PLWLAANGGHLDVVQLLVQA 1124
            PL LA      D+  LL+ A
Sbjct: 939  PLDLATAD---DIRALLIDA 955



 Score =  207 bits (526), Expect = 1e-52
 Identities = 233/791 (29%), Positives = 342/791 (43%), Gaps = 114/791 (14%)

Query: 236 RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEG--ESLLCLACSAGYYELAQVLLAMHANV 293
           R L EAC  GDV+ V++ L++  +VN     G   S L  A   G  ++ + LL M ANV
Sbjct: 184 RELLEACRNGDVSRVKR-LVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242

Query: 294 EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
             R   G + PL  A + GH ++V LLL   AD NA+ +   T L  A   G +DV  VL
Sbjct: 243 HARD-DGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301

Query: 354 LESGASIEDHNENGHT--------------------PLMEAGSAGHVEVARLLLENGAGI 393
           L+ GA     N +G +                     L+EA  +G+ E    LL     +
Sbjct: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALL-TPLNV 360

Query: 394 NTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 452
           N H+++ ++S  L LA     + +V+ LL+ GAD   K       L  AC  GH EV  L
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420

Query: 453 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN-------DEGYTP-- 503
           LL  GA VN       +PL  AA    VE+ +LL+  GA    VN       D   TP  
Sbjct: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480

Query: 504 ------------LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG---GFLE 548
                       L++AARE     V   L     IN +  ++ ETAL  A         +
Sbjct: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLHPKRKQ 539

Query: 549 VADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYAC 605
           V + L++ GA++        TPL  AA+  H ++++ L   GA ++A    G TAL  A 
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599

Query: 606 ENGHTDVADVLLQAGAD---------------------LEHESEGGRTP-----LMKAAR 639
             GH     +LL  G+D                     +  ES   RT      L++A++
Sbjct: 600 LAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASK 659

Query: 640 AGHVCTVQFLISKGANVN-RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGS 698
           AG + TV+ L S   NVN R       T L  A     ++VVE LL HGAD   + K G 
Sbjct: 660 AGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGL 718

Query: 699 TMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPP 758
             L  A   GH  V   L+ +  ++  A   D+ + T P H+     +  +  L ++   
Sbjct: 719 VPLHNACSYGHYEVAELLVRHGASVNVA---DLWKFT-PLHEAAAKGKYEICKL-LLKHG 773

Query: 759 QEPDKPPANVATTLPIRNKA-------VSGRASAMSNTPTHSIAASISQPQTPTPSPIIS 811
            +P K   +  T L +  +        + G A A+ +       A + +  TP       
Sbjct: 774 ADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDA-ALLDAAKKGCLARVQKLCTPE------ 826

Query: 812 PSAMLPIYPAIDIDAQ-TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLI 870
                      +I+ + T+  + T L LA    + E+ + LLE GA +  +DK G  PL 
Sbjct: 827 -----------NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLH 875

Query: 871 LAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930
            AA+ GHV +  +L+     + A +++   TPL  A   GR ++  LLLA GA+   +N 
Sbjct: 876 NAASYGHVDIAALLIKYNTCVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQ 934

Query: 931 SDYTPLSLAAS 941
              TPL LA +
Sbjct: 935 EGQTPLDLATA 945



 Score =  194 bits (494), Expect = 7e-49
 Identities = 212/796 (26%), Positives = 331/796 (41%), Gaps = 136/796 (17%)

Query: 438  LMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLTLAACGGHVELAALLIERGASLEE 495
            L+EAC +G V   + L+D+ A VN    A    SPL  AA  G  ++   L++ GA++  
Sbjct: 186  LLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244

Query: 496  VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK 555
             +D G  PL  A   GH E+V+LLL QGA+ NA+ +    T L  A   G ++V   L++
Sbjct: 245  RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR-DNWNYTPLHEAAIKGKIDVCIVLLQ 303

Query: 556  AGADIE---------LGCSTP--------------LMEAAQEGHLE-LVKYLLAAGANVH 591
             GAD           L  + P              L+EAA+ G+ E L+  L     N H
Sbjct: 304  HGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCH 363

Query: 592  ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651
            A+     T L  A       +  +LLQ GAD+  + +GG  PL  A   GH    + L+ 
Sbjct: 364  ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423

Query: 652  KGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTS 711
             GA VN        T L  A +   + V  LLL+HGADPT     G + +          
Sbjct: 424  HGACVNAMDLWQ-FTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVD--------- 473

Query: 712  VVCYLLDYPNNLLSAPPPDVTQLTP---PSHDLNRAPRVPVQALPMVVPPQEPDKPPANV 768
                          AP P++ +        H L +A R               +   A V
Sbjct: 474  -------------MAPTPELRERLTYEFKGHSLLQAAR---------------EADLAKV 505

Query: 769  ATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQT 828
              TL +  + ++ +      T  H   AS+   +      ++   A +            
Sbjct: 506  KKTLAL--EIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV-----------N 552

Query: 829  ESNHD--TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886
            E N D  T L +A    H ++++ L + GA +   D  G T L  AA AGH+    +LL 
Sbjct: 553  EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLS 612

Query: 887  NGAD-----------------------IEAQSERTKDTP---LSLACSGGRQEVVELLLA 920
             G+D                        E+   RT D     L  + +G  + V +L  +
Sbjct: 613  YGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSS 672

Query: 921  RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHT 980
            +  N         TPL  AA    V++++ LL+ GA+++++   K G+ PL  A   GH 
Sbjct: 673  QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAK--DKGGLVPLHNACSYGHY 730

Query: 981  AAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPL-- 1038
               +LL+  G+ +N   +  + T L  A  +G+ E+  LLL   A+   + + G TPL  
Sbjct: 731  EVAELLVRHGASVNVA-DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789

Query: 1039 ------------------MEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1079
                              ++AA  G  A V ++   +  ++N         T L +AA  
Sbjct: 790  VKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE--NINCRDTQGRNSTPLHLAAGY 847

Query: 1080 GHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1139
             + +  E L+  GA ++ ++K G  PL  AA+ GH+D+  LL++    V+A D    TPL
Sbjct: 848  NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907

Query: 1140 MAAFRKGHVKVVRYLV 1155
              A +KG  ++   L+
Sbjct: 908  HEAAQKGRTQLCALLL 923



 Score =  177 bits (449), Expect = 1e-43
 Identities = 208/747 (27%), Positives = 313/747 (41%), Gaps = 108/747 (14%)

Query: 209 SCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
           +C+   A      +   +  NA  + N + L EA  +G ++    LL  G   N    +G
Sbjct: 256 ACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDG 315

Query: 268 ESLLCLACSA------GYYELAQVLLAMHANVEDR----------------GIKGDITPL 305
           +S L LA  +      G Y+  ++L A  +  E++                G K   TPL
Sbjct: 316 KSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKS--TPL 373

Query: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
             AA    V+IV+LLL H ADV+A+   G   L  AC+ G+ +V ++LL+ GA +   + 
Sbjct: 374 HLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDL 433

Query: 366 NGHTPLMEAGSAGHVEVARLLLENGAG---INTHSN-----------------EFKESAL 405
              TPL EA S   VEV  LLL +GA    +N H                   EFK  +L
Sbjct: 434 WQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSL 493

Query: 406 TLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH---VEVARLLLDSGAQVNM 462
             A  +  L  V+  L        +     TAL  A    H    +V  LLL  GA VN 
Sbjct: 494 LQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNE 553

Query: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
               F +PL +AA   H ++  +L + GA +  ++  G T L  AA  GH +   LLL  
Sbjct: 554 KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSY 613

Query: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG-CSTPLMEAAQEGHLELVK 581
           G++ +  + +      T A  G   E    ++     I        L+EA++ G LE VK
Sbjct: 614 GSDPSIISLQ----GFTAAQMGN--EAVQQILSESTPIRTSDVDYRLLEASKAGDLETVK 667

Query: 582 YLLAAGANVHATTATG--DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
             L +  NV+     G   T L +A       V + LL  GAD+  + +GG  PL  A  
Sbjct: 668 Q-LCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACS 726

Query: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
            GH    + L+  GA+VN        T L  A A G   + +LLL HGADPT + +DG+T
Sbjct: 727 YGHYEVAELLVRHGASVNVADLWK-FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNT 785

Query: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQ 759
            L +  K G T +         +LL             +  L+ A +  +  +  +  P+
Sbjct: 786 PL-DLVKEGDTDI--------QDLLRG----------DAALLDAAKKGCLARVQKLCTPE 826

Query: 760 EPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIY 819
                         I  +   GR    ++TP H +AA  +  +           A   + 
Sbjct: 827 N-------------INCRDTQGR----NSTPLH-LAAGYNNLEV----------AEYLLE 858

Query: 820 PAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVG 879
              D++AQ +      L  A + GH ++   L++    +   DK  FTPL  AA  G   
Sbjct: 859 HGADVNAQDKGGL-IPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQ 917

Query: 880 VVEILLDNGADIEAQSERTKDTPLSLA 906
           +  +LL +GAD   +++  + TPL LA
Sbjct: 918 LCALLLAHGADPTMKNQEGQ-TPLDLA 943



 Score =  169 bits (429), Expect = 2e-41
 Identities = 204/741 (27%), Positives = 310/741 (41%), Gaps = 123/741 (16%)

Query: 504  LMEAAREGHEEMVALLLGQGANINAQTEETQETA-LTLACCGGFLEVADFLIKAGADIEL 562
            L+EA R G    V  L+   AN+NA+    ++++ L  A   G  +V + L++ GA++  
Sbjct: 186  LLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244

Query: 563  ---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQA 619
               G   PL  A   GH E+V  LL  GA+ +A      T L  A   G  DV  VLLQ 
Sbjct: 245  RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304

Query: 620  GADLEHESEGGRTPL--------------------MKAARAGHVCTVQFLISKGANVN-R 658
            GAD    +  G++ L                    ++AAR+G+   +  L++   NVN  
Sbjct: 305  GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP-LNVNCH 363

Query: 659  TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
             +     T L LA     + +V+LLL HGAD   + K G   L  A   GH  V   LL 
Sbjct: 364  ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423

Query: 719  YPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPD------KPPANVATTL 772
            +   + +    D+ Q TP  H+     RV V +L ++    +P       K   ++A T 
Sbjct: 424  HGACVNAM---DLWQFTP-LHEAASKNRVEVCSL-LLSHGADPTLVNCHGKSAVDMAPTP 478

Query: 773  PIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNH 832
             +R +              HS+  +  +         +  +  L I     I+ +   +H
Sbjct: 479  ELRERLTY-------EFKGHSLLQAAREADLAK----VKKTLALEI-----INFKQPQSH 522

Query: 833  DTALTLACAGGH---EELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
            +TAL  A A  H   +++ + LL +GA++  ++K   TPL +AA   H  V+E+L  +GA
Sbjct: 523  ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGA 582

Query: 890  DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949
             + A  +    T L  A   G  +   LLL+ G++    ++  +T    AA  G   + +
Sbjct: 583  KMNAL-DTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQ 637

Query: 950  ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009
            IL  +     S    +L     + A+  G    VK L    +     +E   +T L  A 
Sbjct: 638  ILSESTPIRTSDVDYRL-----LEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAA 692

Query: 1010 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1069
               R  VV  LL   A+V  + K GL PL  A S G+ EV  +L+  GA VN   +   +
Sbjct: 693  GYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADL--WK 750

Query: 1070 DTALTIAADKGHYKFCELLIGRGAHIDVRN------------------------------ 1099
             T L  AA KG Y+ C+LL+  GA    +N                              
Sbjct: 751  FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDA 810

Query: 1100 -KKG-----------------------NTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135
             KKG                       +TPL LAA   +L+V + L++ GADV+A D   
Sbjct: 811  AKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870

Query: 1136 ITPLMAAFRKGHVKVVRYLVK 1156
            + PL  A   GHV +   L+K
Sbjct: 871  LIPLHNAASYGHVDIAALLIK 891



 Score =  154 bits (388), Expect = 1e-36
 Identities = 196/725 (27%), Positives = 291/725 (40%), Gaps = 126/725 (17%)

Query: 521  GQGANINAQTEETQETALTLACCGGFLEVADFLIKAG----ADIELGCSTPLMEAAQEGH 576
            G G  + A +   +E  L  AC  G +     L+ A      D+    S+PL  AA  G 
Sbjct: 171  GPGTGVPAVSGALRE--LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGR 228

Query: 577  LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
             ++V++LL  GANVHA    G   L  AC  GH +V  +LL  GAD         TPL +
Sbjct: 229  KDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHE 288

Query: 637  AARAGHVCTVQFLISKGANVN-RTT-------------------------------ANND 664
            AA  G +     L+  GA+ N R T                               + N+
Sbjct: 289  AAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNE 348

Query: 665  HTVLS---------------------LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703
              +++                     LA     + +V+LLL HGAD   + K G   L  
Sbjct: 349  EKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHN 408

Query: 704  AAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEP-- 761
            A   GH  V   LL +          D+ Q T P H+     RV V +L ++    +P  
Sbjct: 409  ACSYGHYEVTELLLKHG---ACVNAMDLWQFT-PLHEAASKNRVEVCSL-LLSHGADPTL 463

Query: 762  ----DKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAA-SISQPQTPTPSPIISPSAML 816
                 K   ++A T  +R +             T+     S+ Q         +  +  L
Sbjct: 464  VNCHGKSAVDMAPTPELRERL------------TYEFKGHSLLQAAREADLAKVKKTLAL 511

Query: 817  PIYPAIDIDAQTESNHDTALTLACAGGH---EELVQTLLERGASIEHRDKKGFTPLILAA 873
             I     I+ +   +H+TAL  A A  H   +++ + LL +GA++  ++K   TPL +AA
Sbjct: 512  EI-----INFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAA 566

Query: 874  TAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY 933
               H  V+E+L  +GA + A  +    T L  A   G  +   LLL+ G++    ++  +
Sbjct: 567  ERAHNDVMEVLHKHGAKMNA-LDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGF 625

Query: 934  TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 993
            T    AA  G   + +IL  +     S    +     L+ A+  G    VK L    +  
Sbjct: 626  T----AAQMGNEAVQQILSESTPIRTSDVDYR-----LLEASKAGDLETVKQLCSSQNVN 676

Query: 994  NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1053
               +E   +T L  A    R  VV  LL   A+V  + K GL PL  A S G+ EV  +L
Sbjct: 677  CRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELL 736

Query: 1054 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGG 1113
            +  GA VN   +   + T L  AA KG Y+ C+LL+  GA    +N+ GNTPL L    G
Sbjct: 737  VRHGASVNVADL--WKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-G 793

Query: 1114 HLDVVQLLVQAGADVDAA----------------------DNRKITPLMAAFRKGHVKVV 1151
              D+  LL    A +DAA                        R  TPL  A    +++V 
Sbjct: 794  DTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVA 853

Query: 1152 RYLVK 1156
             YL++
Sbjct: 854  EYLLE 858



 Score =  110 bits (274), Expect = 2e-23
 Identities = 117/394 (29%), Positives = 176/394 (44%), Gaps = 27/394 (6%)

Query: 869  LILAATAGHVGVVEILLDNGADIEAQSER-TKDTPLSLACSGGRQEVVELLLARGANKEH 927
            L+ A   G V  V+ L+D  A++ A+     K +PL  A   GR++VVE LL  GAN   
Sbjct: 186  LLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244

Query: 928  RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLL 987
            R+     PL  A S G+  ++ +LL  GA+ N+R       +PL  AA+ G      +LL
Sbjct: 245  RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR--DNWNYTPLHEAAIKGKIDVCIVLL 302

Query: 988  DMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1047
              G+D N +  T+  +AL LA             D  A      +     L+EAA  G  
Sbjct: 303  QHGADPNIR-NTDGKSALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNE 348

Query: 1048 EVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLW 1107
            E    LL    +VN       + T L +AA     +  +LL+  GA +  ++K G  PL 
Sbjct: 349  EKLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLH 407

Query: 1108 LAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSEC 1167
             A + GH +V +LL++ GA V+A D  + TPL  A  K  V+V   L+      P+   C
Sbjct: 408  NACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH-GADPTLVNC 466

Query: 1168 MRYIATITDKEMLKKCHLCME----SIVQAKDRQAAEANKNASILLEELDLEKLREESRR 1223
                A         +  L  E    S++QA  R+A  A    ++ LE ++ +  + +S  
Sbjct: 467  HGKSAVDMAPTPELRERLTYEFKGHSLLQAA-READLAKVKKTLALEIINFK--QPQSHE 523

Query: 1224 LALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKE 1257
             AL         KR++  E   RK   +  KNK+
Sbjct: 524  TALHCAVASLHPKRKQVTELLLRKGANVNEKNKD 557



 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 102/313 (32%), Positives = 134/313 (42%), Gaps = 23/313 (7%)

Query: 830  SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKG--FTPLILAATAGHVGVVEILLDN 887
            S+ D  L  A   G  E V+ L     ++  RD +G   TPL  AA    V VVE LL +
Sbjct: 648  SDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHH 706

Query: 888  GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNI 947
            GAD+ A+ ++    PL  ACS G  EV ELL+  GA+    ++  +TPL  AA+ G   I
Sbjct: 707  GADVHAK-DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEI 765

Query: 948  IKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL 1007
             K+LL  GA+   +  ++ G +PL L                  D + Q     + AL  
Sbjct: 766  CKLLLKHGADPTKK--NRDGNTPLDLVKEG--------------DTDIQDLLRGDAALLD 809

Query: 1008 ACFQG-RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1066
            A  +G    V  L      N         TPL  AA     EV   LL+ GADVNA    
Sbjct: 810  AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869

Query: 1067 SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1126
                  L  AA  GH     LLI     ++  +K   TPL  AA  G   +  LL+  GA
Sbjct: 870  GL--IPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 927

Query: 1127 DVDAADNRKITPL 1139
            D    +    TPL
Sbjct: 928  DPTMKNQEGQTPL 940



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 80/257 (31%), Positives = 116/257 (45%), Gaps = 47/257 (18%)

Query: 926  EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKL 985
            E   VS   PL   A+G            G  + + +G+   +  L+ A  NG  + VK 
Sbjct: 155  EAAGVSSTAPLGPGAAG-----------PGTGVPAVSGA---LRELLEACRNGDVSRVKR 200

Query: 986  LLDMGSDINAQIETNRNTA-LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASG 1044
            L+D  +++NA+    R ++ L  A   GR +VV  LL   ANV  R   GL PL  A S 
Sbjct: 201  LVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSF 259

Query: 1045 GYAEVGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCELLIGRGAHIDVRNK 1100
            G+AEV  +LL +GAD      P++RD    T L  AA KG    C +L+  GA  ++RN 
Sbjct: 260  GHAEVVSLLLCQGAD------PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNT 313

Query: 1101 KGNTPLWL---------------------AANGGHLDVVQLLVQAGADVDAADNRKITPL 1139
             G + L L                     A +G    ++ LL     +  A+D RK TPL
Sbjct: 314  DGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPL 373

Query: 1140 MAAFRKGHVKVVRYLVK 1156
              A     V++V+ L++
Sbjct: 374  HLAAGYNRVRIVQLLLQ 390



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 84/314 (26%), Positives = 127/314 (40%), Gaps = 67/314 (21%)

Query: 205 TSSVSCALDEAAAA-----LTRMRAESTANAGQSDNRS---LAEACSEGDVNAVRKLLIE 256
           TS V   L EA+ A     + ++ +    N    + R    L  A     V+ V  LL  
Sbjct: 647 TSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHH 706

Query: 257 GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKI 316
           G  V+   + G   L  ACS G+YE+A++L+   A+V    +    TPL  AA  G  +I
Sbjct: 707 GADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADL-WKFTPLHEAAAKGKYEI 765

Query: 317 VKLLLAHKAD-------------------------------------------------- 326
            KLLL H AD                                                  
Sbjct: 766 CKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP 825

Query: 327 --VNAQSSTGNTALTYACAGGY--VDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEV 382
             +N + + G  +     A GY  ++V + LLE GA +   ++ G  PL  A S GHV++
Sbjct: 826 ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDI 885

Query: 383 ARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEAC 442
           A LL++    +N  ++++  + L  A  KG  ++   LL  GAD   K  E  T L  A 
Sbjct: 886 AALLIKYNTCVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT 944

Query: 443 MDGHVEVARLLLDS 456
            D   ++  LL+D+
Sbjct: 945 AD---DIRALLIDA 955



 Score = 38.5 bits (88), Expect = 0.079
 Identities = 42/165 (25%), Positives = 61/165 (36%), Gaps = 27/165 (16%)

Query: 1854 HSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPM 1913
            H  Q QP    S  P PP      PPP      P LA  + P +  ++    +  P+  +
Sbjct: 14   HQQQLQPAPGASAPPPPP------PPP----LSPGLAPGTTPASPTASGLAPFASPRHGL 63

Query: 1914 GCPQPTPKMETPAIRP----PPHGTTAPHKNSA-----------SVQNSSVAVLSVNHI- 1957
              P+     + P  RP    P  GT+     S            +V  SS A ++ N   
Sbjct: 64   ALPEGDGSRDPPD-RPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAG 122

Query: 1958 KRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGP 2002
               ++ PSS   P++ S+ S        A  P A   S+  P GP
Sbjct: 123  SGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGP 167



 Score = 37.7 bits (86), Expect = 0.13
 Identities = 27/91 (29%), Positives = 39/91 (42%)

Query: 1788 PVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSS 1847
            P   P SP P       S  S +   +A+P   A S+   AG  P    + +    SSSS
Sbjct: 74   PPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSS 133

Query: 1848 SGSSSAHSNQQQPPGSVSQEPRPPLQQSQVP 1878
            S +SS+ S+   P  S+++ P      S  P
Sbjct: 134  SPTSSSSSSPSSPGSSLAESPEAAGVSSTAP 164



 Score = 32.0 bits (71), Expect = 7.4
 Identities = 33/149 (22%), Positives = 52/149 (34%)

Query: 1681 LSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSS 1740
            L PA   ++P P   P  S   + G+   S  +   +P  +     +   G  +   P  
Sbjct: 18   LQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDR 77

Query: 1741 PSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ 1800
            P     +  T   ++ +T  TV         + ++A    P        +SPSS S P  
Sbjct: 78   PRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTS 137

Query: 1801 PGGVSRNSPLDCGSASPNKVASSSEQEAG 1829
                S +SP    + SP     SS    G
Sbjct: 138  SSSSSPSSPGSSLAESPEAAGVSSTAPLG 166


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  206 bits (523), Expect = 3e-52
 Identities = 226/802 (28%), Positives = 343/802 (42%), Gaps = 112/802 (13%)

Query: 224 AESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGY--YE 281
           A + A A +   R L EAC  GDV  V++ L+    VN     G     L  +AG+   +
Sbjct: 14  ASAAAEAVEPAARELFEACRNGDVERVKR-LVTPEKVNSRDTAGRKSTPLHFAAGFGRKD 72

Query: 282 LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
           + + LL   ANV+ R   G + PL  A + GH ++V LLL H AD NA+ +   T L  A
Sbjct: 73  VVEYLLQNGANVQARD-DGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEA 131

Query: 342 CAGGYVDVVKVLLESGASIEDHNENGHT--------------------PLMEAGSAGHVE 381
              G +DV  VLL+ GA     N +G T                     L+E+  +G+ E
Sbjct: 132 AIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEE 191

Query: 382 VARLLLENGAGINTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
               LL     +N H+++ ++S  L LA     +++V+ LL+ GAD   K       L  
Sbjct: 192 KMMALL-TPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHN 250

Query: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN--- 497
           AC  GH EV  LL+  GA VN       +PL  AA    VE+ +LL+  GA    +N   
Sbjct: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310

Query: 498 ----DEGYTP--------------LMEAAREGHEEMVALLLGQGANINAQTEETQETALT 539
               D   TP              L++AARE     +   L     +N +  +T ETAL 
Sbjct: 311 KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSL-EMVNFKHPQTHETALH 369

Query: 540 LACCGGF---LEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHAT 593
            A    +    ++ + L++ GA+I        TPL  A+++ H ++V+ ++   A V+A 
Sbjct: 370 CAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNAL 429

Query: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRT--------------------- 632
              G T+L  A   GH     +LL  G D    S  G T                     
Sbjct: 430 DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGN 489

Query: 633 -----PLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687
                 L++AA+AG V TV+ L +  +   R       T L  A     ++VVE LL HG
Sbjct: 490 SEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG 549

Query: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRV 747
           AD   + K G   L  A   GH  V   L+ +   +  A   D+ + T P H+     + 
Sbjct: 550 ADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA---DLWKFT-PLHEAAAKGKY 605

Query: 748 PVQALPMVVPPQEPDKPPANVATTLPIRNKA-------VSGRASAMSNTPTHSIAASISQ 800
            +  L ++    +P K   +  T L +           + G A A+ +       A + +
Sbjct: 606 EICKL-LLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDA-ALLDAAKKGCLARVKK 663

Query: 801 PQTPTPSPIISPSAMLPIYPAIDIDAQ-TESNHDTALTLACAGGHEELVQTLLERGASIE 859
             +P                  +++ + T+  H T L LA    + E+ + LL+ GA + 
Sbjct: 664 LSSPD-----------------NVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVN 706

Query: 860 HRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL 919
            +DK G  PL  AA+ GHV V  +L+   A + A +++   TPL  A   GR ++  LLL
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA-TDKWAFTPLHEAAQKGRTQLCALLL 765

Query: 920 ARGANKEHRNVSDYTPLSLAAS 941
           A GA+   +N    TPL L ++
Sbjct: 766 AHGADPTLKNQEGQTPLDLVSA 787



 Score =  172 bits (435), Expect = 5e-42
 Identities = 203/741 (27%), Positives = 305/741 (41%), Gaps = 123/741 (16%)

Query: 504  LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL- 562
            L EA R G  E V  L+      +  T   + T L  A   G  +V ++L++ GA+++  
Sbjct: 28   LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87

Query: 563  --GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
              G   PL  A   GH E+V  LL  GA+ +A      T L  A   G  DV  VLLQ G
Sbjct: 88   DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 147

Query: 621  ADLEHESEGGRTPL--------------------MKAARAGHVCTVQFLISKGANVN-RT 659
            A+    +  GRT L                    +++AR+G+   +  L++   NVN   
Sbjct: 148  AEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHA 206

Query: 660  TANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
            +     T L LA     + +V+LLL HGAD   + K     L  A   GH  V   L+ +
Sbjct: 207  SDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKH 266

Query: 720  PNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAV 779
               + +    D+ Q TP  H+     RV V +L ++    +P        T L   NK  
Sbjct: 267  GACVNAM---DLWQFTP-LHEAASKNRVEVCSL-LLSYGADP--------TLLNCHNK-- 311

Query: 780  SGRASAMSNTPTHSIAASISQP-------QTPTPSPIISPSAMLPIYPAIDIDAQTESNH 832
                SA+   PT  +   ++         Q    + +      L +     ++ +    H
Sbjct: 312  ----SAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM---VNFKHPQTH 364

Query: 833  DTALTLACAGGH---EELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
            +TAL  A A  +   +++ + LL +GA+I  + K+  TPL +A+   H  VVE+++ + A
Sbjct: 365  ETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA 424

Query: 890  DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949
             + A  +    T L  A   G  +   LLL+ G +    ++  +T L +         ++
Sbjct: 425  KVNAL-DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQ 478

Query: 950  ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009
             LL  G  + +    +     L+ AA  G    VK L  + S     IE  ++T L  A 
Sbjct: 479  QLLQEGISLGNSEADR----QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAA 534

Query: 1010 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1069
               R  VV  LL   A+V  + K GL PL  A S G+ EV  +L+  GA VN   +   +
Sbjct: 535  GYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADL--WK 592

Query: 1070 DTALTIAADKGHYKFCELLIGRGAHIDVRN------------------------------ 1099
             T L  AA KG Y+ C+LL+  GA    +N                              
Sbjct: 593  FTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDA 652

Query: 1100 -KKG-----------------------NTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135
             KKG                       +TPL LAA   +L+V + L+Q GADV+A D   
Sbjct: 653  AKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGG 712

Query: 1136 ITPLMAAFRKGHVKVVRYLVK 1156
            + PL  A   GHV V   L+K
Sbjct: 713  LIPLHNAASYGHVDVAALLIK 733



 Score =  167 bits (423), Expect = 1e-40
 Identities = 223/836 (26%), Positives = 338/836 (40%), Gaps = 159/836 (19%)

Query: 209 SCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
           +C+   A      +R  +  NA  + N + L EA  +G ++    LL  G        +G
Sbjct: 98  ACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDG 157

Query: 268 ESLLCLACSA------GYYELAQVLLAMHANVEDR----------------GIKGDITPL 305
            + L LA  +      G Y+  ++L +  +  E++                G K   TPL
Sbjct: 158 RTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKS--TPL 215

Query: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
             AA    VKIV+LLL H ADV+A+       L  AC+ G+ +V ++L++ GA +   + 
Sbjct: 216 HLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDL 275

Query: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLAC-----------YKGH- 413
              TPL EA S   VEV  LLL  GA   T  N   +SA+ LA            +KGH 
Sbjct: 276 WQFTPLHEAASKNRVEVCSLLLSYGAD-PTLLNCHNKSAIDLAPTPQLKERLAYEFKGHS 334

Query: 414 ------------------LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 455
                             LEMV F       Q H+T  +H A          ++  LLL 
Sbjct: 335 LLQAAREADVTRIKKHLSLEMVNF----KHPQTHET-ALHCAAASP-YPKRKQICELLLR 388

Query: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515
            GA +N     F +PL +A+   H ++  ++++  A +  +++ G T L  AA  GH + 
Sbjct: 389 KGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQT 448

Query: 516 VALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAA 572
             LLL  G + N  + +   TAL +       E    L++ G  I LG S     L+EAA
Sbjct: 449 CRLLLSYGCDPNIISLQ-GFTALQMG-----NENVQQLLQEG--ISLGNSEADRQLLEAA 500

Query: 573 QEGHLELVKYLLAA-GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 631
           + G +E VK L      N         T L +A       V + LLQ GAD+  + +GG 
Sbjct: 501 KAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGL 560

Query: 632 TPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPT 691
            PL  A   GH    + L+  GA VN        T L  A A G   + +LLL HGADPT
Sbjct: 561 VPLHNACSYGHYEVAELLVKHGAVVNVADLWK-FTPLHEAAAKGKYEICKLLLQHGADPT 619

Query: 692 HRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQA 751
            + +DG+T L +  K G T +                           DL R     + A
Sbjct: 620 KKNRDGNTPL-DLVKDGDTDI--------------------------QDLLRGDAALLDA 652

Query: 752 -----LPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTP 806
                L  V     PD           +  +   GR S    TP H +AA  +  +    
Sbjct: 653 AKKGCLARVKKLSSPDN----------VNCRDTQGRHS----TPLH-LAAGYNNLEV--- 694

Query: 807 SPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGF 866
                  A   +    D++AQ +      L  A + GH ++   L++  A +   DK  F
Sbjct: 695 -------AEYLLQHGADVNAQDKGGL-IPLHNAASYGHVDVAALLIKYNACVNATDKWAF 746

Query: 867 TPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGG---------------- 910
           TPL  AA  G   +  +LL +GAD   +++  + TPL L  +                  
Sbjct: 747 TPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQ-TPLDLVSADDVSALLTAAMPPSALPS 805

Query: 911 --RQEVVELLLARGANKEHRNVSDYTPLSLAA-------SGGYVNIIKILLNAGAE 957
             + +V+  + + GA  +  +    +P SL+A       SG +  +  ++ ++G E
Sbjct: 806 CYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTE 861



 Score =  162 bits (411), Expect = 3e-39
 Identities = 196/727 (26%), Positives = 296/727 (40%), Gaps = 94/727 (12%)

Query: 502  TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561
            TPL  AA  G +++V  LL  GAN+ A+ ++     L  AC  G  EV + L++ GAD  
Sbjct: 60   TPLHFAAGFGRKDVVEYLLQNGANVQAR-DDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118

Query: 562  LGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVA----- 613
               +   TPL EAA +G +++   LL  GA        G TAL  A  +    +      
Sbjct: 119  ARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKK 178

Query: 614  DVLLQAGADLE---------------HESEGGR-TPLMKAARAGHVCTVQFLISKGANVN 657
            D LL++                    H S+G + TPL  AA    V  VQ L+  GA+V+
Sbjct: 179  DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVH 238

Query: 658  RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
                  D   L  AC+ GH  V ELL+ HGA          T L EAA      V   LL
Sbjct: 239  AKD-KGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297

Query: 718  DYPNN--LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIR 775
             Y  +  LL+        L P +  L        +   ++   +E D        +L + 
Sbjct: 298  SYGADPTLLNCHNKSAIDLAP-TPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM- 355

Query: 776  NKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTA 835
               V+ +      T  H  AAS        P P       L +    +I+ +T+    T 
Sbjct: 356  ---VNFKHPQTHETALHCAAAS--------PYPKRKQICELLLRKGANINEKTKE-FLTP 403

Query: 836  LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD----- 890
            L +A    H ++V+ +++  A +   D  G T L  AA  GH+    +LL  G D     
Sbjct: 404  LHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIIS 463

Query: 891  ---------------------IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRN 929
                                 I   +       L  A +G  + V +L   +  N     
Sbjct: 464  LQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIE 523

Query: 930  VSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDM 989
                TPL  AA    V++++ LL  GA+++++   K G+ PL  A   GH    +LL+  
Sbjct: 524  GRQSTPLHFAAGYNRVSVVEYLLQHGADVHAK--DKGGLVPLHNACSYGHYEVAELLVKH 581

Query: 990  GSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPL----------- 1038
            G+ +N   +  + T L  A  +G+ E+  LLL   A+   + + G TPL           
Sbjct: 582  GAVVNVA-DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQ 640

Query: 1039 ---------MEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1088
                     ++AA  G  A V +  L    +VN         T L +AA   + +  E L
Sbjct: 641  DLLRGDAALLDAAKKGCLARVKK--LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYL 698

Query: 1089 IGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHV 1148
            +  GA ++ ++K G  PL  AA+ GH+DV  LL++  A V+A D    TPL  A +KG  
Sbjct: 699  LQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRT 758

Query: 1149 KVVRYLV 1155
            ++   L+
Sbjct: 759  QLCALLL 765



 Score =  154 bits (390), Expect = 8e-37
 Identities = 195/746 (26%), Positives = 315/746 (42%), Gaps = 111/746 (14%)

Query: 196 ADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLI 255
           ADP +L     S   A+D A     + R      A +    SL +A  E DV  ++K L 
Sbjct: 301 ADPTLLNCHNKS---AIDLAPTPQLKERL-----AYEFKGHSLLQAAREADVTRIKKHLS 352

Query: 256 EGRSVNEHTEEGESLLCLACSAGY---YELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
                 +H +  E+ L  A ++ Y    ++ ++LL   AN+ ++  K  +TPL  A+   
Sbjct: 353 LEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEK-TKEFLTPLHVASEKA 411

Query: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGA-----------SIE 361
           H  +V++++ H+A VNA  + G T+L  A   G++   ++LL  G            +++
Sbjct: 412 HNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQ 471

Query: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAG--------------INTHSNEFKESA-LT 406
             NEN    L E  S G+ E  R LLE                  +N    E ++S  L 
Sbjct: 472 MGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLH 531

Query: 407 LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466
            A     + +V +LL+ GAD   K       L  AC  GH EVA LL+  GA VN+ AD 
Sbjct: 532 FAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV-ADL 590

Query: 467 FE-SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGAN 525
           ++ +PL  AA  G  E+  LL++ GA   + N +G TPL +  ++G  ++  LL G  A 
Sbjct: 591 WKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRGDAAL 649

Query: 526 INAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLA 585
           ++A  +          C     +++        D +   STPL  AA   +LE+ +YLL 
Sbjct: 650 LDAAKK---------GCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQ 700

Query: 586 AGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCT 645
            GA+V+A    G   L  A   GH DVA +L++  A +    +   TPL +AA+ G    
Sbjct: 701 HGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGR--- 757

Query: 646 VQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 705
                                  +  CA        LLLAHGADPT + ++G T L +  
Sbjct: 758 -----------------------TQLCA--------LLLAHGADPTLKNQEGQTPL-DLV 785

Query: 706 KGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPP 765
                S +      P+ L S   P V           R+P     AL     P  P    
Sbjct: 786 SADDVSALLTAAMPPSALPSCYKPQVLNGV-------RSPGATADALSS--GPSSPSS-- 834

Query: 766 ANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAM-LPIYPAIDI 824
            + A++L   + + S  +S +S++ T   A+S+ + + P     I+     L +   +DI
Sbjct: 835 LSAASSLDNLSGSFSELSSVVSSSGTEG-ASSLEKKEVPGVDFSITQFVRNLGLEHLMDI 893

Query: 825 DAQTESNHDTALTLACAGGHEELVQT---------LLERGASIEHRDKKGFTPLILAATA 875
             + +   D  + +    GH+EL +           L +G       ++G  P +   T+
Sbjct: 894 FEREQITLDVLVEM----GHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTS 949

Query: 876 GHVGVVEILLDNGADIEAQSERTKDT 901
           G   ++  L  +  + ++  E  + T
Sbjct: 950 GSGTILIDLSPDDKEFQSVEEEMQST 975



 Score =  118 bits (295), Expect = 8e-26
 Identities = 99/296 (33%), Positives = 136/296 (45%), Gaps = 21/296 (7%)

Query: 829  ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 888
            E    T L  A       +V+ LL+ GA +  +DK G  PL  A + GH  V E+L+ +G
Sbjct: 523  EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582

Query: 889  ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 948
            A +   ++  K TPL  A + G+ E+ +LLL  GA+   +N    TPL L   G     I
Sbjct: 583  AVVNV-ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGD--TDI 639

Query: 949  KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1008
            + LL              G + L+ AA  G  A VK L    +      +   +T L LA
Sbjct: 640  QDLLR-------------GDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLA 686

Query: 1009 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1068
                  EV   LL   A+V  + K GL PL  AAS G+ +V  +L+   A VNA      
Sbjct: 687  AGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA--TDKW 744

Query: 1069 RDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1124
              T L  AA KG  + C LL+  GA   ++N++G TPL L +     DV  LL  A
Sbjct: 745  AFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD---DVSALLTAA 797



 Score =  106 bits (264), Expect = 3e-22
 Identities = 114/375 (30%), Positives = 161/375 (42%), Gaps = 28/375 (7%)

Query: 899  KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 958
            K TPL  A   GR++VVE LL  GAN + R+     PL  A S G+  ++ +LL  GA+ 
Sbjct: 58   KSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADP 117

Query: 959  NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS 1018
            N+R       +PL  AA+ G      +LL  G++      T RNT        GRT +  
Sbjct: 118  NAR--DNWNYTPLHEAAIKGKIDVCIVLLQHGAE-----PTIRNT-------DGRTALD- 162

Query: 1019 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1078
             L D  A      +     L+E+A  G  E    LL    +VN       + T L +AA 
Sbjct: 163  -LADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAG 220

Query: 1079 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP 1138
                K  +LL+  GA +  ++K    PL  A + GH +V +LLV+ GA V+A D  + TP
Sbjct: 221  YNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTP 280

Query: 1139 LMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCME----SIVQ-A 1193
            L  A  K  V+V   L+      P+   C    A         K  L  E    S++Q A
Sbjct: 281  LHEAASKNRVEVCSLLL-SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAA 339

Query: 1194 KDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEA 1253
            ++       K+ S+ +      +  E +   A A+   KRK+      E   RK   I  
Sbjct: 340  READVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ----ICELLLRKGANINE 395

Query: 1254 KNKENF-ELQAAQEK 1267
            K KE    L  A EK
Sbjct: 396  KTKEFLTPLHVASEK 410



 Score = 98.2 bits (243), Expect = 8e-20
 Identities = 96/315 (30%), Positives = 138/315 (43%), Gaps = 16/315 (5%)

Query: 191 DGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAV 250
           +G +  + E  R+L  +      E    L  +++ +  +     +  L  A     V+ V
Sbjct: 483 EGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVV 542

Query: 251 RKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAAN 310
             LL  G  V+   + G   L  ACS G+YE+A+ LL  H  V +       TPL  AA 
Sbjct: 543 EYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE-LLVKHGAVVNVADLWKFTPLHEAAA 601

Query: 311 GGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
            G  +I KLLL H AD   ++  GNT L         D+VK   +    I+D    G   
Sbjct: 602 KGKYEICKLLLQHGADPTKKNRDGNTPL---------DLVK---DGDTDIQD-LLRGDAA 648

Query: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEH 429
           L++A   G +   +  L +   +N    + + S  L LA    +LE+  +LL+ GAD   
Sbjct: 649 LLDAAKKGCLARVK-KLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707

Query: 430 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
           +       L  A   GHV+VA LL+   A VN       +PL  AA  G  +L ALL+  
Sbjct: 708 QDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAH 767

Query: 490 GASLEEVNDEGYTPL 504
           GA     N EG TPL
Sbjct: 768 GADPTLKNQEGQTPL 782



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 107/314 (34%), Positives = 135/314 (42%), Gaps = 25/314 (7%)

Query: 830  SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKG--FTPLILAATAGHVGVVEILLDN 887
            S  D  L  A   G  E V+ L     S+  RD +G   TPL  AA    V VVE LL +
Sbjct: 490  SEADRQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548

Query: 888  GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNI 947
            GAD+ A+ ++    PL  ACS G  EV ELL+  GA     ++  +TPL  AA+ G   I
Sbjct: 549  GADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607

Query: 948  IKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL 1007
             K+LL  GA+   +  ++ G +PL L                  D + Q     + AL  
Sbjct: 608  CKLLLQHGADPTKK--NRDGNTPLDLVK--------------DGDTDIQDLLRGDAALLD 651

Query: 1008 ACFQGRTEVVSLLLDRKANVEHRAKTGL--TPLMEAASGGYAEVGRVLLDKGADVNAPPV 1065
            A  +G    V  L     NV  R   G   TPL  AA     EV   LL  GADVNA   
Sbjct: 652  AAKKGCLARVKKL-SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDK 710

Query: 1066 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1125
                   L  AA  GH     LLI   A ++  +K   TPL  AA  G   +  LL+  G
Sbjct: 711  GGL--IPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 768

Query: 1126 ADVDAADNRKITPL 1139
            AD    +    TPL
Sbjct: 769  ADPTLKNQEGQTPL 782


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  184 bits (468), Expect = 7e-46
 Identities = 133/407 (32%), Positives = 204/407 (50%), Gaps = 6/407 (1%)

Query: 347 VDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT 406
           +  +K LLE    +++ NE G TPLM A   G++E+ + L++NGA  N    +   +AL 
Sbjct: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALI 76

Query: 407 LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466
            A  +GH+ +V  LL+ G + EH+     TALM AC  G  +V  LLL  GA  ++    
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136

Query: 467 FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526
              P+  AA  GH ++  LL++ GA +   +  G TPL+ AAR+GH E V  LL  GA++
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196

Query: 527 NAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYL 583
           + Q      TAL +A  GG+ +    ++K   ++ L     +T LM A++EGH E+V+ L
Sbjct: 197 D-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255

Query: 584 LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHV 643
           L AG  V+    +GDT L  A   GH ++   LLQ  AD++   +  +T L  A   G+ 
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315

Query: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703
             V+ ++    +    T + + T L  A    ++ VVELLL  GA  +   K G T L  
Sbjct: 316 TMVRDILQCNPDTEICTKDGE-TPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI 374

Query: 704 AAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQ 750
           A +G    +   LL  P +      P+    TP + D +    +  Q
Sbjct: 375 AIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQ 421



 Score =  172 bits (436), Expect = 3e-42
 Identities = 120/333 (36%), Positives = 175/333 (52%), Gaps = 7/333 (2%)

Query: 823  DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
            D+D + E    T L +A   G+ E+V+ L++ GA+    D   +T LI A+  GHV +VE
Sbjct: 30   DVDERNECGQ-TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVE 88

Query: 883  ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942
             LL  G ++E   +    T L  AC  GR +VVELLL+ GAN     +    P+  AA  
Sbjct: 89   ELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGR 147

Query: 943  GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1002
            G+ +I+ +LL  GA++N     K G +PL+ AA  GH   VK LL MG+D++ Q   N  
Sbjct: 148  GHADIVHLLLQNGAKVN--CSDKYGTTPLVWAARKGHLECVKHLLAMGADVD-QEGANSM 204

Query: 1003 TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1062
            TAL +A   G T+ V  +L R  NV    K G T LM A+  G+ E+ + LLD G  VN 
Sbjct: 205  TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI 264

Query: 1063 PPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1122
            P    S DT L  A   GH +    L+ + A ID+R +   T L+ A   G+  +V+ ++
Sbjct: 265  P--DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDIL 322

Query: 1123 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155
            Q   D +       TPL+ A +  +++VV  L+
Sbjct: 323  QCNPDTEICTKDGETPLIKATKMRNIEVVELLL 355



 Score =  168 bits (425), Expect = 7e-41
 Identities = 117/380 (30%), Positives = 190/380 (50%), Gaps = 6/380 (1%)

Query: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLM 372
           ++  +K LL    DV+ ++  G T L  A   G +++VK L+++GA+    + +  T L+
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76

Query: 373 EAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD 432
            A   GHV +   LL+ G  +  H +    +AL  ACYKG  ++V  LL  GA+      
Sbjct: 77  SASKEGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135

Query: 433 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAS 492
                ++ A   GH ++  LLL +GA+VN       +PL  AA  GH+E    L+  GA 
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195

Query: 493 LEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADF 552
           +++      T L+ A + G+ + V  +L +  N+N  T++   TAL +A   G  E+   
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQD 254

Query: 553 LIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGH 609
           L+ AG  + +      T L+ A + GH+E+V+ LL   A++        TAL +A E G+
Sbjct: 255 LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGN 314

Query: 610 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLS 669
             +   +LQ   D E  ++ G TPL+KA +  ++  V+ L+ KGA V+      D T L 
Sbjct: 315 ATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGD-TPLH 373

Query: 670 LACAGGHLAVVELLLAHGAD 689
           +A  G    + ELLL +  D
Sbjct: 374 IAIRGRSRKLAELLLRNPKD 393



 Score =  153 bits (387), Expect = 2e-36
 Identities = 108/323 (33%), Positives = 167/323 (51%), Gaps = 6/323 (1%)

Query: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
            TAL  A   GH  +V+ LL+ G ++EHRD  G+T L+ A   G   VVE+LL +GA+  +
Sbjct: 73   TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN-PS 131

Query: 894  QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 953
             +      P+  A   G  ++V LLL  GA     +    TPL  AA  G++  +K LL 
Sbjct: 132  VTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA 191

Query: 954  AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1013
             GA+++    + +  + L++A   G+T +VK +L    ++N   + + NTAL +A  +G 
Sbjct: 192  MGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGH 248

Query: 1014 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1073
            TE+V  LLD    V    ++G T L+ A  GG+ E+ R LL K AD++         TAL
Sbjct: 249  TEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIR--GQDNKTAL 306

Query: 1074 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADN 1133
              A +KG+      ++      ++  K G TPL  A    +++VV+LL+  GA V A D 
Sbjct: 307  YWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDK 366

Query: 1134 RKITPLMAAFRKGHVKVVRYLVK 1156
            +  TPL  A R    K+   L++
Sbjct: 367  KGDTPLHIAIRGRSRKLAELLLR 389



 Score =  152 bits (383), Expect = 5e-36
 Identities = 111/359 (30%), Positives = 183/359 (50%), Gaps = 6/359 (1%)

Query: 284 QVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACA 343
           + LL    +V++R   G  TPLM AA  G+++IVK L+ + A+ N +     TAL  A  
Sbjct: 22  KALLEKCKDVDERNECGQ-TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80

Query: 344 GGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKES 403
            G+V +V+ LL+ G ++E  +  G T LM A   G  +V  LLL +GA  +  +  +   
Sbjct: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV-TGLYSVY 139

Query: 404 ALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP 463
            +  A  +GH ++V  LL+ GA          T L+ A   GH+E  + LL  GA V+  
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199

Query: 464 ADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523
             +  + L +A  GG+ +    +++R  ++   + +G T LM A++EGH E+V  LL  G
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAG 259

Query: 524 ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELV 580
             +N   + + +T L  A  GG +E+   L++  ADI++      T L  A ++G+  +V
Sbjct: 260 TYVNI-PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318

Query: 581 KYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
           + +L    +    T  G+T L  A +  + +V ++LL  GA +    + G TPL  A R
Sbjct: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR 377



 Score =  137 bits (346), Expect = 1e-31
 Identities = 99/335 (29%), Positives = 168/335 (50%), Gaps = 4/335 (1%)

Query: 226 STANAGQSDN-RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQ 284
           +  N    DN  +L  A  EG V+ V +LL  G ++      G + L  AC  G  ++ +
Sbjct: 62  ANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVE 121

Query: 285 VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344
           +LL+  AN    G+   + P++ AA  GH  IV LLL + A VN     G T L +A   
Sbjct: 122 LLLSHGANPSVTGLY-SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARK 180

Query: 345 GYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESA 404
           G+++ VK LL  GA ++    N  T L+ A   G+ +  + +L+    +N  +++   +A
Sbjct: 181 GHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTA 239

Query: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464
           L +A  +GH E+V+ LL+AG           T L+ A   GHVE+ R LL   A +++  
Sbjct: 240 LMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG 299

Query: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524
              ++ L  A   G+  +   +++     E    +G TPL++A +  + E+V LLL +GA
Sbjct: 300 QDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGA 359

Query: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGAD 559
            ++A  ++  +T L +A  G   ++A+ L++   D
Sbjct: 360 KVSA-VDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393



 Score =  137 bits (345), Expect = 1e-31
 Identities = 102/306 (33%), Positives = 158/306 (51%), Gaps = 9/306 (2%)

Query: 413 HLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 472
           ++  ++ LLE   D + + +   T LM A   G++E+ + L+ +GA  N+      + L 
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76

Query: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532
            A+  GHV +   L++ G +LE  +  G+T LM A  +G  ++V LLL  GAN +  T  
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV-TGL 135

Query: 533 TQETALTLACCGGFLEVADFLIKAGADIELGCS-----TPLMEAAQEGHLELVKYLLAAG 587
                +  A   G  ++   L++ GA  ++ CS     TPL+ AA++GHLE VK+LLA G
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGA--KVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193

Query: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQ 647
           A+V    A   TAL  A + G+T     +L+   ++    + G T LM A++ GH   VQ
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253

Query: 648 FLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 707
            L+  G  VN    + D TVL  A  GGH+ +V  LL   AD   R +D  T L  A + 
Sbjct: 254 DLLDAGTYVNIPDRSGD-TVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312

Query: 708 GHTSVV 713
           G+ ++V
Sbjct: 313 GNATMV 318



 Score =  131 bits (329), Expect = 9e-30
 Identities = 105/349 (30%), Positives = 178/349 (51%), Gaps = 17/349 (4%)

Query: 877  HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL 936
            ++  ++ LL+   D++ ++E    TPL +A   G  E+V+ L+  GAN    ++ ++T L
Sbjct: 17   NIPALKALLEKCKDVDERNE-CGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75

Query: 937  SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 996
              A+  G+V+I++ LL  G  +  R     G + LM A   G T  V+LLL  G++ +  
Sbjct: 76   ISASKEGHVHIVEELLKCGVNLEHRDMG--GWTALMWACYKGRTDVVELLLSHGANPSV- 132

Query: 997  IETNRNTALTL--ACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1054
              T   +   +  A  +G  ++V LLL   A V    K G TPL+ AA  G+ E  + LL
Sbjct: 133  --TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL 190

Query: 1055 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGH 1114
              GADV+     S   TAL +A   G+ +  + ++ R  ++++ +K GNT L +A+  GH
Sbjct: 191  AMGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGH 248

Query: 1115 LDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK---EVNQFPSDSECMRYI 1171
             ++VQ L+ AG  V+  D    T L+ A R GHV++VR L++   +++    D++   Y 
Sbjct: 249  TEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYW 308

Query: 1172 A----TITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEK 1216
            A      T    + +C+   E   +  +    +A K  +I + EL L+K
Sbjct: 309  AVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDK 357



 Score =  122 bits (305), Expect = 5e-27
 Identities = 94/270 (34%), Positives = 136/270 (50%), Gaps = 9/270 (3%)

Query: 839  ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 898
            A   GH ++V  LL+ GA +   DK G TPL+ AA  GH+  V+ LL  GAD++ +   +
Sbjct: 144  AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203

Query: 899  KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 958
              T L +A  GG  + V+ +L R  N    +    T L +A+  G+  I++ LL+AG  +
Sbjct: 204  M-TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYV 262

Query: 959  NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS 1018
            N     + G + L+ A   GH   V+ LL   +DI+ + + N+ TAL  A  +G   +V 
Sbjct: 263  N--IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVR 319

Query: 1019 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1078
             +L    + E   K G TPL++A      EV  +LLDKGA V+A  V    DT L IA  
Sbjct: 320  DILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA--VDKKGDTPLHIAIR 377

Query: 1079 KGHYKFCELLIGR---GAHIDVRNKKGNTP 1105
                K  ELL+     G  +   NK G TP
Sbjct: 378  GRSRKLAELLLRNPKDGRLLYRPNKAGETP 407



 Score =  119 bits (298), Expect = 4e-26
 Identities = 121/413 (29%), Positives = 184/413 (44%), Gaps = 52/413 (12%)

Query: 616  LLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGG 675
            LL+   D++  +E G+TPLM AA  G++  V+ LI  GAN N    +N  T L  A   G
Sbjct: 24   LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDN-WTALISASKEG 82

Query: 676  HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLT 735
            H+ +VE LL  G +  HR   G T L+ A   G T VV  LL +  N      P VT L 
Sbjct: 83   HVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN------PSVTGLY 136

Query: 736  PPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIA 795
                                              +  PI   A  G A  +     +   
Sbjct: 137  ----------------------------------SVYPIIWAAGRGHADIVHLLLQNGAK 162

Query: 796  ASISQPQTPTPSPIISPSAMLPIYPAI-----DIDAQTESNHDTALTLACAGGHEELVQT 850
             + S     TP    +    L     +     D+D Q  +N  TAL +A  GG+ + V+ 
Sbjct: 163  VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD-QEGANSMTALIVAVKGGYTQSVKE 221

Query: 851  LLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGG 910
            +L+R  ++   DK G T L++A+  GH  +V+ LLD G  +    +R+ DT L  A  GG
Sbjct: 222  ILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI-PDRSGDTVLIGAVRGG 280

Query: 911  RQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISP 970
              E+V  LL + A+ + R   + T L  A   G   +++ +L    +    T  K G +P
Sbjct: 281  HVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICT--KDGETP 338

Query: 971  LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR 1023
            L+ A    +   V+LLLD G+ ++A ++   +T L +A  +GR+  ++ LL R
Sbjct: 339  LIKATKMRNIEVVELLLDKGAKVSA-VDKKGDTPLHIA-IRGRSRKLAELLLR 389



 Score =  115 bits (289), Expect = 4e-25
 Identities = 117/423 (27%), Positives = 181/423 (42%), Gaps = 40/423 (9%)

Query: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
           S  ++   +E ++  +K LL    +V      G T L  A E G+ ++   L++ GA+  
Sbjct: 6   SQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN 65

Query: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
            E     T L+ A++ GHV  V+ L+  G N+         T L  AC  G   VVELLL
Sbjct: 66  LEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG-WTALMWACYKGRTDVVELLL 124

Query: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRA 744
           +HGA+P+         +I AA  GH  +V  LL    N       D    TP      + 
Sbjct: 125 SHGANPSVTGLYSVYPIIWAAGRGHADIVHLLL---QNGAKVNCSDKYGTTPLVWAARKG 181

Query: 745 PRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTP 804
               V+ L  +    + D+  AN  T L +          A+    T S+   + +    
Sbjct: 182 HLECVKHL--LAMGADVDQEGANSMTALIV----------AVKGGYTQSVKEILKR---- 225

Query: 805 TPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKK 864
                 +P+  L           T+ + +TAL +A   GH E+VQ LL+ G  +   D+ 
Sbjct: 226 ------NPNVNL-----------TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRS 268

Query: 865 GFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGAN 924
           G T LI A   GHV +V  LL   ADI+ + +  K T L  A   G   +V  +L    +
Sbjct: 269 GDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVRDILQCNPD 327

Query: 925 KEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVK 984
            E       TPL  A     + ++++LL+ GA++++    K G +PL +A         +
Sbjct: 328 TEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA--VDKKGDTPLHIAIRGRSRKLAE 385

Query: 985 LLL 987
           LLL
Sbjct: 386 LLL 388



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 2/91 (2%)

Query: 833 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD-- 890
           +T L  A    + E+V+ LL++GA +   DKKG TPL +A       + E+LL N  D  
Sbjct: 336 ETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGR 395

Query: 891 IEAQSERTKDTPLSLACSGGRQEVVELLLAR 921
           +  +  +  +TP ++ CS  +  + ++  AR
Sbjct: 396 LLYRPNKAGETPYNIDCSHQKSILTQIFGAR 426


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score =  172 bits (436), Expect = 3e-42
 Identities = 132/396 (33%), Positives = 199/396 (50%), Gaps = 54/396 (13%)

Query: 313  HVKIVKLLLAHKADVNAQSSTGNTA--LTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
            ++K+ +LL+   A++N ++   N A  L      GY ++V +LLE GA+++  +E+G TP
Sbjct: 862  NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921

Query: 371  LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE-----AGA 425
            L  A +AG++ +  LL +  A ++ H ++  + AL  A  +GHLE+V+FL++     AG 
Sbjct: 922  LGYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980

Query: 426  DQE--HKTDEMHTALMEACMDGHVEVARLLLD---------SGAQVNMPADSF--ESPLT 472
             Q    K+  +  AL+ A   G+ E+   LLD           AQ+N   DS   E+ LT
Sbjct: 981  QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWGETALT 1039

Query: 473  LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532
             AA  G +E+  LL+E+GA++ + N  G  PL    R+GH ++V LLL  GA++N   ++
Sbjct: 1040 AAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQ 1099

Query: 533  TQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHA 592
             +                               TPLM AA EGHL  V +LLA GA++  
Sbjct: 1100 GR-------------------------------TPLMMAASEGHLGTVDFLLAQGASIAL 1128

Query: 593  TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
                G TAL++AC  GH  V   L+  GA  +H  + GRTPL  AA  G    VQFL+  
Sbjct: 1129 MDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 1188

Query: 653  GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
            GA +     +     L  A    + +VV  LL  GA
Sbjct: 1189 GAMIEHVDYSGMRP-LDRAVGCRNTSVVVTLLKKGA 1223



 Score =  150 bits (378), Expect = 2e-35
 Identities = 109/333 (32%), Positives = 170/333 (51%), Gaps = 26/333 (7%)

Query: 410  YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV---EVARLLLDSGAQVNMPADS 466
            Y  ++++ R L+  GA+  ++T+ ++ A +  C+  H+   E+  LLL+ GA V+  ++S
Sbjct: 859  YTPNIKVSRLLILGGANINYRTEVLNNAPI-LCVQSHLGYTEMVALLLEFGANVDASSES 917

Query: 467  FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL------ 520
              +PL  AA  G++ +  LL ++ A ++ ++  G   L+ AA  GH E+V  L+      
Sbjct: 918  GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 977

Query: 521  -GQGANINAQTEETQETALTLACCGGFLEVADFLI----KAGADIE---------LGCST 566
             GQ   +  ++   Q+ AL  A   G+ E+  +L+    K   ++E         L   T
Sbjct: 978  AGQQQGVFKKSHAIQQ-ALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGET 1036

Query: 567  PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 626
             L  AA  G LE+ + LL  GA V      G   L      GH  + D+LL  GAD+   
Sbjct: 1037 ALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMA 1096

Query: 627  SEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAH 686
             + GRTPLM AA  GH+ TV FL+++GA++         T LS AC  GHL+VV  L+ +
Sbjct: 1097 DKQGRTPLMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGHLSVVRSLVDN 1155

Query: 687  GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
            GA   H  K+G T L  AA  G   VV +L+D+
Sbjct: 1156 GAATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 1188



 Score =  147 bits (371), Expect = 1e-34
 Identities = 117/370 (31%), Positives = 172/370 (46%), Gaps = 23/370 (6%)

Query: 246  DVNAVRKLLIEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDIT 303
            ++   R L++ G ++N  TE      +LC+    GY E+  +LL   ANV D   +  +T
Sbjct: 862  NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANV-DASSESGLT 920

Query: 304  PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH 363
            PL  AA  G++ IV LL   +A V+     G  AL +A   G+++VVK L++   ++   
Sbjct: 921  PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980

Query: 364  NEN----GHT---PLMEAGSAGHVEVARLLLE---------NGAGINTHSNEFKESALTL 407
             +      H     L+ A S G+ E+   LL+           A IN+  + + E+ALT 
Sbjct: 981  QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTA 1040

Query: 408  ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
            A  +G LE+ R LLE GA            L      GH ++  LLL  GA VNM     
Sbjct: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100

Query: 468  ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
             +PL +AA  GH+     L+ +GAS+  ++ EG T L  A  +GH  +V  L+  GA  +
Sbjct: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1160

Query: 528  AQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPLMEAAQEGHLELVKYLL 584
               ++   T L LA   G  EV  FL+  GA IE        PL  A    +  +V  LL
Sbjct: 1161 -HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219

Query: 585  AAGANVHATT 594
              GA +   T
Sbjct: 1220 KKGAKIGPAT 1229



 Score =  130 bits (328), Expect = 1e-29
 Identities = 150/503 (29%), Positives = 222/503 (44%), Gaps = 40/503 (7%)

Query: 807  SPIISPSAMLPIYPAIDIDAQTES-NHDTALTLACAGGHEELVQTLLERGASIEHRDKKG 865
            +P I  S +L I    +I+ +TE  N+   L +    G+ E+V  LLE GA+++   + G
Sbjct: 860  TPNIKVSRLL-ILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESG 918

Query: 866  FTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLA----- 920
             TPL  AA AG++ +V +L    A ++   ++     L  A   G  EVV+ L+      
Sbjct: 919  LTPLGYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 977

Query: 921  ----RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG---------AEINSRTGSKLG 967
                +G  K+   +     L  AAS GY  I+  LL+           A+INS   S  G
Sbjct: 978  AGQQQGVFKKSHAIQQ--ALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWG 1034

Query: 968  ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL--ACFQGRTEVVSLLLDRKA 1025
             + L  AA  G     +LLL+ G+   A  + NR  A+ L     QG  ++V LLL   A
Sbjct: 1035 ETALTAAAGRGKLEVCRLLLEQGA---AVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 1091

Query: 1026 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1085
            +V    K G TPLM AAS G+      LL +GA +    +     TAL+ A  KGH    
Sbjct: 1092 DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL--MDKEGLTALSWACLKGHLSVV 1149

Query: 1086 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1145
              L+  GA  D  +K G TPL LAA  G  +VVQ LV  GA ++  D   + PL  A   
Sbjct: 1150 RSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGC 1209

Query: 1146 GHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNA 1205
             +  VV  L+K+  +    +  M    +  D  ++    L  E  +  K  +  EA +  
Sbjct: 1210 RNTSVVVTLLKKGAKIGPATWAM--ATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRY 1267

Query: 1206 SILLEEL-------DLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKEN 1258
               L++        DL+  RE    L L   R +RK       EE   K  E++ K+ E 
Sbjct: 1268 QYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEA 1327

Query: 1259 FELQAAQEKEKLKVEDEPEVLTE 1281
            +  +A  ++   +     E L E
Sbjct: 1328 YYARARAKRSSRQFAAALEDLNE 1350



 Score =  129 bits (324), Expect = 3e-29
 Identities = 112/390 (28%), Positives = 164/390 (42%), Gaps = 63/390 (16%)

Query: 245  GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITP 304
            G    V  LL  G +V+  +E G + L  A +AGY  +  +L    A V+     G    
Sbjct: 896  GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCA- 954

Query: 305  LMAAANGGHVKIVKLLL------------------------------------------- 321
            L+ AA  GH+++VK L+                                           
Sbjct: 955  LVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLP 1014

Query: 322  ------AHKADVNA-QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEA 374
                    +A +N+  S  G TALT A   G ++V ++LLE GA++   N  G  PL   
Sbjct: 1015 EKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFST 1074

Query: 375  GSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEM 434
               GH ++  LLL +GA +N    + + + L +A  +GHL  V FLL  GA       E 
Sbjct: 1075 VRQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEG 1133

Query: 435  HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLE 494
             TAL  AC+ GH+ V R L+D+GA  +    +  +PL LAA  G  E+   L++ GA +E
Sbjct: 1134 LTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1193

Query: 495  EVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT--EETQETALTLACCGGFLEVADF 552
             V+  G  PL  A    +  +V  LL +GA I   T    T +  + +      +E  D 
Sbjct: 1194 HVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDM 1253

Query: 553  LIKAGADIELGCSTPLMEAAQEGHLELVKY 582
              K G          + EAAQ     L K+
Sbjct: 1254 FYKKG---------KVKEAAQRYQYALKKF 1274



 Score =  129 bits (323), Expect = 4e-29
 Identities = 112/359 (31%), Positives = 164/359 (45%), Gaps = 21/359 (5%)

Query: 379  HVEVARLLLENGAGINTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTA 437
            +++V+RLL+  GA IN  +     +  L +  + G+ EMV  LLE GA+ +  ++   T 
Sbjct: 862  NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921

Query: 438  LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE----RGASL 493
            L  A   G++ +  LL    A+V+    + +  L  AA  GH+E+   LI+         
Sbjct: 922  LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981

Query: 494  EEVNDEGYT---PLMEAAREGHEEMVALLLG---------QGANINAQTEETQETALTLA 541
            + V  + +     L+ AA  G+ E+V+ LL          + A IN+      ETALT A
Sbjct: 982  QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041

Query: 542  CCGGFLEVADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
               G LEV   L++ GA +       + PL    ++GH ++V  LL  GA+V+     G 
Sbjct: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101

Query: 599  TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
            T L  A   GH    D LL  GA +    + G T L  A   GH+  V+ L+  GA  + 
Sbjct: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161

Query: 659  TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
               N   T L LA   G   VV+ L+ HGA   H    G   L  A    +TSVV  LL
Sbjct: 1162 ADKNG-RTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219



 Score =  119 bits (298), Expect = 4e-26
 Identities = 115/406 (28%), Positives = 174/406 (42%), Gaps = 57/406 (14%)

Query: 576  HLELVKYLLAAGANVHATTATGDTALTYACEN--GHTDVADVLLQAGADLEHESEGGRTP 633
            ++++ + L+  GAN++  T   + A     ++  G+T++  +LL+ GA+++  SE G TP
Sbjct: 862  NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921

Query: 634  LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA-------- 685
            L  AA AG++  V  L  K A V+    N    ++  A  G HL VV+ L+         
Sbjct: 922  LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRG-HLEVVKFLIQCDWTMAGQ 980

Query: 686  -HGA-DPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNR 743
              G    +H ++     LI AA  G+T +V YLLD P                   D   
Sbjct: 981  QQGVFKKSHAIQQA---LIAAASMGYTEIVSYLLDLPEK-----------------DEEE 1020

Query: 744  APRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQT 803
              R  + +          D      A T      A +GR             A+++QP  
Sbjct: 1021 VERAQINSF---------DSLWGETALT------AAAGRGKLEVCRLLLEQGAAVAQPNR 1065

Query: 804  PTPSPIISPSAM-------LPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGA 856
                P+ S           L +    D++   +    T L +A + GH   V  LL +GA
Sbjct: 1066 RGAVPLFSTVRQGHWQIVDLLLTHGADVN-MADKQGRTPLMMAASEGHLGTVDFLLAQGA 1124

Query: 857  SIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVE 916
            SI   DK+G T L  A   GH+ VV  L+DNGA  +  +++   TPL LA   G  EVV+
Sbjct: 1125 SIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD-HADKNGRTPLDLAAFYGDAEVVQ 1183

Query: 917  LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 962
             L+  GA  EH + S   PL  A      +++  LL  GA+I   T
Sbjct: 1184 FLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPAT 1229



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 56/192 (29%), Positives = 80/192 (41%), Gaps = 11/192 (5%)

Query: 177  ALLEAAGIGKLSTA-----DGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAG 231
            AL  AAG GKL         G A A P   RR    +   + +    +  +     A+  
Sbjct: 1037 ALTAAAGRGKLEVCRLLLEQGAAVAQPN--RRGAVPLFSTVRQGHWQIVDLLLTHGADVN 1094

Query: 232  QSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 288
             +D +    L  A SEG +  V  LL +G S+    +EG + L  AC  G+  + + L+ 
Sbjct: 1095 MADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVD 1154

Query: 289  MHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVD 348
              A   D   K   TPL  AA  G  ++V+ L+ H A +     +G   L  A       
Sbjct: 1155 NGA-ATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTS 1213

Query: 349  VVKVLLESGASI 360
            VV  LL+ GA I
Sbjct: 1214 VVVTLLKKGAKI 1225



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 52/224 (23%), Positives = 78/224 (34%), Gaps = 18/224 (8%)

Query: 1724 SSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTA 1783
            S  S+ P   +    SSP    Q+F     +S  + T  T  +++   +PT+        
Sbjct: 1442 SPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQN------ 1495

Query: 1784 KEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPN 1843
              HY  S P +   PA  GG  R SP   G            +E  SPP           
Sbjct: 1496 -SHYRPSPPHTS--PAHQGGSYRFSPPPVGGQG---------KEYPSPPPSPLRRGPQYR 1543

Query: 1844 SSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP 1903
            +S  + S S + +Q   P    QE        +   P  +M   P      PVAVP    
Sbjct: 1544 ASPPAESMSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGL 1603

Query: 1904 VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNS 1947
               P     +   QP+P + +  + P        H  ++  Q+S
Sbjct: 1604 RLQPAKAQIVRSNQPSPAVHSSTVIPTGAYGQVAHSMASKYQSS 1647


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  167 bits (423), Expect = 1e-40
 Identities = 150/448 (33%), Positives = 221/448 (49%), Gaps = 30/448 (6%)

Query: 154 LLSGTADGADLRTVDPETQARL--EALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCA 211
           LLS    G       PE  +R   E+ L ++G GK              L  ++S  S  
Sbjct: 335 LLSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGKR-------------LSGVSSVDSAF 381

Query: 212 LDEAAAALTRMRAESTANAGQSD--NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGES 269
               + +L+  R  ST++ G +D   + L +A   GD + + K+L + + V+   + G S
Sbjct: 382 SSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKIL-QPQDVDLALDSGAS 440

Query: 270 LLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNA 329
           LL LA  AG  E A+ LL  +AN      +G  TPL  A       +V+LLLA K  VNA
Sbjct: 441 LLHLAVEAGQEECAKWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVNA 499

Query: 330 QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389
           +     TAL +A   G     ++LLE  AS+ + +  G TP+  A   G   + R+LL  
Sbjct: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559

Query: 390 GAGINTHSNEFKESALTL--ACYKGHLEMVRFLL-EAGADQEHKTDEMHTALMEACMDGH 446
           G  ++      K++ L L  A ++GHL +V+ L  + G     +T +  T L  A   GH
Sbjct: 560 GVDVSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616

Query: 447 VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLME 506
             VAR+L+D  + VN+ +   ++PL +AA  GH   A LL+ RGA  E +  +GYT L  
Sbjct: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHL 676

Query: 507 AAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA-DI--ELG 563
           AAR GH   V LL+ + A++ A+    Q TAL LA   G  EV + L+ A   D+  E G
Sbjct: 677 AARNGHLATVKLLVEEKADVLARGPLNQ-TALHLAAAHGHSEVVEELVSADVIDLFDEQG 735

Query: 564 CSTPLMEAAQEGHLELVKYLLAAGANVH 591
            S  L  AAQ  H + V+ LL  GA+++
Sbjct: 736 LSA-LHLAAQGRHAQTVETLLRHGAHIN 762



 Score =  136 bits (342), Expect = 3e-31
 Identities = 113/345 (32%), Positives = 165/345 (47%), Gaps = 9/345 (2%)

Query: 813  SAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILA 872
            S ++ I    D+D   +S   + L LA   G EE  + LL   A+    +++G TPL +A
Sbjct: 420  SKLMKILQPQDVDLALDSGA-SLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMA 478

Query: 873  ATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD 932
                  GVVE+LL     + A+ E  + T L  A   G +    LLL + A+    +   
Sbjct: 479  VERRVRGVVELLLARKISVNAKDE-DQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEG 537

Query: 933  YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDM-GS 991
             TP+ +A   G  NI++ILL  G +++ +   K    PL  AA  GH   VKLL    G 
Sbjct: 538  RTPMHVACQHGQENIVRILLRRGVDVSLQ--GKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595

Query: 992  DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1051
             +NAQ    R T L LA  +G   V  +L+D  ++V   +    TPL  AA  G+    R
Sbjct: 596  SVNAQTLDGR-TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654

Query: 1052 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1111
            +LL +GA   A  + S   TAL +AA  GH    +LL+   A +  R     T L LAA 
Sbjct: 655  LLLHRGAGKEA--MTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAA 712

Query: 1112 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
             GH +VV+ LV A   +D  D + ++ L  A +  H + V  L++
Sbjct: 713  HGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLR 756



 Score =  131 bits (330), Expect = 7e-30
 Identities = 117/344 (34%), Positives = 159/344 (46%), Gaps = 20/344 (5%)

Query: 350 VKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLAC 409
           V + L+SGAS+          L  A  AG  E A+ LL N A  N  SN    + L +A 
Sbjct: 431 VDLALDSGASL----------LHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAV 479

Query: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 469
            +    +V  LL        K ++  TAL  A  +G     RLLL+  A VN       +
Sbjct: 480 ERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRT 539

Query: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ-GANINA 528
           P+ +A   G   +  +L+ RG  +     + + PL  AA +GH  +V LL  Q G ++NA
Sbjct: 540 PMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNA 599

Query: 529 QTEETQETALTLACCGGFLEVADFLIKAGADIELGCS----TPLMEAAQEGHLELVKYLL 584
           QT + + T L LA   G   VA  LI   +D+ + CS    TPL  AA+ GH    + LL
Sbjct: 600 QTLDGR-TPLHLAAQRGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETGHTSTARLLL 657

Query: 585 AAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644
             GA   A T+ G TAL  A  NGH     +L++  AD+       +T L  AA  GH  
Sbjct: 658 HRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSE 717

Query: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
            V+ L+S  A+V         + L LA  G H   VE LL HGA
Sbjct: 718 VVEELVS--ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759



 Score =  126 bits (316), Expect = 3e-28
 Identities = 95/297 (31%), Positives = 148/297 (49%), Gaps = 8/297 (2%)

Query: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
            T L +A       +V+ LL R  S+  +D+  +T L  AA  G      +LL+  A +  
Sbjct: 473  TPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNE 532

Query: 894  QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 953
                 + TP+ +AC  G++ +V +LL RG +   +    + PL  AA  G++ I+K+L  
Sbjct: 533  VDFEGR-TPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK 591

Query: 954  A-GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012
              G  +N++T    G +PL LAA  GH    ++L+D+ SD+N        T L +A   G
Sbjct: 592  QPGVSVNAQTLD--GRTPLHLAAQRGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETG 648

Query: 1013 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1072
             T    LLL R A  E     G T L  AA  G+    ++L+++ ADV A        TA
Sbjct: 649  HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARG--PLNQTA 706

Query: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1129
            L +AA  GH +  E L+     ID+ +++G + L LAA G H   V+ L++ GA ++
Sbjct: 707  LHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score =  118 bits (296), Expect = 6e-26
 Identities = 102/303 (33%), Positives = 150/303 (49%), Gaps = 21/303 (6%)

Query: 822  IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 881
            I ++A+ E    TAL  A   G E   + LLE+ AS+   D +G TP+ +A   G   +V
Sbjct: 495  ISVNAKDEDQW-TALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIV 553

Query: 882  EILLDNGADIEAQSERTKDT--PLSLACSGGRQEVVELLLAR-GANKEHRNVSDYTPLSL 938
             ILL  G D+  Q    KD   PL  A   G   +V+LL  + G +   + +   TPL L
Sbjct: 554  RILLRRGVDVSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610

Query: 939  AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE 998
            AA  G+  + +IL++  +++N    S L  +PL +AA  GHT+  +LLL  G+   A + 
Sbjct: 611  AAQRGHYRVARILIDLCSDVN--VCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA-MT 667

Query: 999  TNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1058
            ++  TAL LA   G    V LL++ KA+V  R     T L  AA+ G++EV   L+   A
Sbjct: 668  SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--SA 725

Query: 1059 DVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVV 1118
            DV          +AL +AA   H +  E L+  GAHI++++        L   GGH    
Sbjct: 726  DV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAA 776

Query: 1119 QLL 1121
             LL
Sbjct: 777  TLL 779



 Score =  118 bits (295), Expect = 8e-26
 Identities = 83/278 (29%), Positives = 138/278 (49%), Gaps = 17/278 (6%)

Query: 881  VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 940
            V++ LD+GA +           L LA   G++E  + LL   AN    N    TPL +A 
Sbjct: 431  VDLALDSGASL-----------LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479

Query: 941  SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1000
                  ++++LL     +N++   +   + L  AA NG  ++ +LLL+  + +N +++  
Sbjct: 480  ERRVRGVVELLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEKNASVN-EVDFE 536

Query: 1001 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-GAD 1059
              T + +AC  G+  +V +LL R  +V  + K    PL  AA  G+  + ++L  + G  
Sbjct: 537  GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596

Query: 1060 VNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQ 1119
            VNA  +     T L +AA +GHY+   +LI   + ++V +    TPL +AA  GH    +
Sbjct: 597  VNAQTLDGR--TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654

Query: 1120 LLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
            LL+  GA  +A  +   T L  A R GH+  V+ LV+E
Sbjct: 655  LLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE 692



 Score =  106 bits (264), Expect = 3e-22
 Identities = 94/308 (30%), Positives = 137/308 (44%), Gaps = 7/308 (2%)

Query: 431 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 490
           TD     L++A + G       +L     V++  DS  S L LA   G  E A  L+   
Sbjct: 403 TDVQKKKLVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461

Query: 491 ASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVA 550
           A+    N  G TPL  A       +V LLL +  ++NA+ E+ Q TAL  A   G     
Sbjct: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED-QWTALHFAAQNGDESST 520

Query: 551 DFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACEN 607
             L++  A   +++    TP+  A Q G   +V+ LL  G +V          L YA   
Sbjct: 521 RLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQ 580

Query: 608 GHTDVADVLL-QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666
           GH  +  +L  Q G  +  ++  GRTPL  AA+ GH    + LI   ++VN   +    T
Sbjct: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVN-VCSLLAQT 639

Query: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSA 726
            L +A   GH +   LLL  GA       DG T L  AA+ GH + V  L++   ++L+ 
Sbjct: 640 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLAR 699

Query: 727 PPPDVTQL 734
            P + T L
Sbjct: 700 GPLNQTAL 707



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 58/176 (32%), Positives = 83/176 (47%), Gaps = 3/176 (1%)

Query: 227 TANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQV 285
           + NA   D R+ L  A   G     R L+     VN  +   ++ L +A   G+   A++
Sbjct: 596 SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARL 655

Query: 286 LLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGG 345
           LL   A  E     G  T L  AA  GH+  VKLL+  KADV A+     TAL  A A G
Sbjct: 656 LLHRGAGKEAMTSDG-YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHG 714

Query: 346 YVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401
           + +VV+ L+ +   I+  +E G + L  A    H +    LL +GA IN  S +F+
Sbjct: 715 HSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQ 769


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  160 bits (406), Expect = 1e-38
 Identities = 132/382 (34%), Positives = 177/382 (46%), Gaps = 6/382 (1%)

Query: 278 GYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTA 337
           G  E  ++LLA   +V+ +   G  TPL+ AA      +  LLLAH AD N     G   
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASG-YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431

Query: 338 LTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 397
           L +A   G     ++LL+ GA ++     G TPL  A       VARLL+   A  N H 
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491

Query: 398 NEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 457
            E K + L +A Y GH+ +V+ L   GA+ + +   + T L  A   G V   + LL SG
Sbjct: 492 AEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550

Query: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517
           A  +    S   PL  AA  G   +  +L+  GASLE    +G+TPL  AA +GH E++ 
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610

Query: 518 LLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD---IELGCSTPLMEAAQE 574
           LL    AN+ A       T L LA   G   V   L++ GAD    E    TPL  A Q 
Sbjct: 611 LLAESHANMGA-LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669

Query: 575 GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 634
                V  LL   ANVHA    G T    A   G+T +  VL++AGA L+ +     TPL
Sbjct: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729

Query: 635 MKAARAGHVCTVQFLISKGANV 656
             A R+     + FL  K  +V
Sbjct: 730 QLALRSRKQGIMSFLEGKEPSV 751



 Score =  151 bits (382), Expect = 6e-36
 Identities = 120/365 (32%), Positives = 172/365 (47%), Gaps = 38/365 (10%)

Query: 822  IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 881
            +D+D QT S + T L +A      +L   LL  GA     D+ G+ PL  AA  G  G  
Sbjct: 386  VDVDCQTASGY-TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTA 444

Query: 882  EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 941
             +LLD+GA ++AQ ER   TPL LA     + V  LL++R A+         TPL +AA 
Sbjct: 445  RLLLDHGACVDAQ-EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAY 503

Query: 942  GGYVNIIKILLNAGAEI-----NSRTGSKL--------------------------GISP 970
             G+V+++K+L + GAE+     N RT   L                          G  P
Sbjct: 504  FGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP 563

Query: 971  LMLAAMNGHTAAVKLLLDMGSDINAQIETNRN-TALTLACFQGRTEVVSLLLDRKANVEH 1029
            L  AA  G     K+LL  G+ +  ++ T++  T L LA ++G  E++ LL +  AN+  
Sbjct: 564  LHTAAARGKYLICKMLLRYGASL--ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA 621

Query: 1030 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1089
                  TPL  AA  G   V   LL  GAD NA     S  T L +A  +  +     L+
Sbjct: 622  LGAVNWTPLHLAARHGEEAVVSALLQCGADPNA--AEQSGWTPLHLAVQRSTFLSVINLL 679

Query: 1090 GRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVK 1149
               A++  RNK G TP  LAA  G+  ++++LV+AGA +D  D    TPL  A R     
Sbjct: 680  EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQG 739

Query: 1150 VVRYL 1154
            ++ +L
Sbjct: 740  IMSFL 744



 Score =  135 bits (340), Expect = 5e-31
 Identities = 108/330 (32%), Positives = 157/330 (47%), Gaps = 7/330 (2%)

Query: 831  NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 890
            N  T L    A G  E V+ LL     ++ +   G+TPL++AA      +  +LL +GAD
Sbjct: 361  NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420

Query: 891  IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 950
                 E     PL  A   G      LLL  GA  + +    +TPL LAA   + N+ ++
Sbjct: 421  ANRVDE-DGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 951  LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACF 1010
            L++  A+ N       G +PL +AA  GH + VKLL   G++++AQ + N  T L LA  
Sbjct: 480  LVSRQADPNLHEAE--GKTPLHVAAYFGHVSLVKLLTSQGAELDAQ-QRNLRTPLHLAVE 536

Query: 1011 QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1070
            +G+   +  LL   A  +   ++G  PL  AA+ G   + ++LL  GA +  P       
Sbjct: 537  RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP--THQGW 594

Query: 1071 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1130
            T L +AA KGH +   LL    A++        TPL LAA  G   VV  L+Q GAD +A
Sbjct: 595  TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654

Query: 1131 ADNRKITPL-MAAFRKGHVKVVRYLVKEVN 1159
            A+    TPL +A  R   + V+  L    N
Sbjct: 655  AEQSGWTPLHLAVQRSTFLSVINLLEHHAN 684



 Score =  128 bits (321), Expect = 8e-29
 Identities = 114/368 (30%), Positives = 169/368 (45%), Gaps = 11/368 (2%)

Query: 364 NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF-----KESALTLACYKGHLEMVR 418
           NE+    LM++ S  +++ A L L +   +     E      K + L     +G +E VR
Sbjct: 321 NEDISQELMDSDSGNYLKRA-LQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVR 379

Query: 419 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 478
            LL    D + +T   +T L+ A  D   ++  LLL  GA  N   +   +PL  AA  G
Sbjct: 380 LLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNG 439

Query: 479 HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538
               A LL++ GA ++    EG+TPL  AA+   E +  LL+ + A+ N   E   +T L
Sbjct: 440 DDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH-EAEGKTPL 498

Query: 539 TLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTA 595
            +A   G + +   L   GA+++       TPL  A + G +  +++LL +GA   A   
Sbjct: 499 HVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQ 558

Query: 596 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGAN 655
           +G   L  A   G   +  +LL+ GA LE  +  G TPL  AA  GH+  +  L    AN
Sbjct: 559 SGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHAN 618

Query: 656 VNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCY 715
           +    A N  T L LA   G  AVV  LL  GADP    + G T L  A +      V  
Sbjct: 619 MGALGAVN-WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN 677

Query: 716 LLDYPNNL 723
           LL++  N+
Sbjct: 678 LLEHHANV 685



 Score =  124 bits (310), Expect = 1e-27
 Identities = 116/357 (32%), Positives = 161/357 (45%), Gaps = 6/357 (1%)

Query: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
           EN  TPL    + G VE  RLLL +   ++  +     + L +A      ++   LL  G
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTAS-GYTPLLIAAQDQQPDLCALLLAHG 418

Query: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484
           AD     ++    L  A  +G    ARLLLD GA V+       +PL LAA      +A 
Sbjct: 419 ADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVAR 478

Query: 485 LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
           LL+ R A       EG TPL  AA  GH  +V LL  QGA ++AQ +    T L LA   
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQ-QRNLRTPLHLAVER 537

Query: 545 GFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601
           G +     L+K+GA    ++     PL  AA  G   + K LL  GA++   T  G T L
Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597

Query: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661
             A   GH ++  +L ++ A++        TPL  AAR G    V  L+  GA+ N    
Sbjct: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN-AAE 656

Query: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
            +  T L LA        V  LL H A+   R K G T    AA  G+T+++  L++
Sbjct: 657 QSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVE 713



 Score =  120 bits (301), Expect = 2e-26
 Identities = 92/289 (31%), Positives = 141/289 (48%), Gaps = 2/289 (0%)

Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
           A   GD    R LL  G  V+    EG + L LA    +  +A++L++  A+      +G
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494

Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
             TPL  AA  GHV +VKLL +  A+++AQ     T L  A   G V  ++ LL+SGA  
Sbjct: 495 K-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553

Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
           +  +++G+ PL  A + G   + ++LL  GA +   +++   + L LA YKGHLE++  L
Sbjct: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ-GWTPLHLAAYKGHLEIIHLL 612

Query: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
            E+ A+         T L  A   G   V   LL  GA  N    S  +PL LA      
Sbjct: 613 AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTF 672

Query: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529
                L+E  A++   N  G+TP   AA +G+  ++ +L+  GA ++ Q
Sbjct: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721



 Score =  102 bits (253), Expect = 6e-21
 Identities = 117/412 (28%), Positives = 174/412 (42%), Gaps = 25/412 (6%)

Query: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
           TPL     +G +E V+ LLA   +V   TA+G T L  A ++   D+  +LL  GAD   
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
             E G  PL  AA+ G   T + L+  GA V+        T L LA       V  LL++
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVD-AQEREGWTPLHLAAQNNFENVARLLVS 482

Query: 686 HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQ--LTPPSHDLNR 743
             ADP     +G T L  AA  GH S+V  L      L      D  Q  L  P H    
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL------DAQQRNLRTPLH--LA 534

Query: 744 APRVPVQALPMVVPPQE-PDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQ 802
             R  V+A+  ++     PD    + +   P+   A  G+         +  +  +   Q
Sbjct: 535 VERGKVRAIQHLLKSGAVPDA--LDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ 592

Query: 803 TPTPSPIISPSAMLPIYPAIDIDAQTESNHD-------TALTLACAGGHEELVQTLLERG 855
             TP  + +    L I   I + A++ +N         T L LA   G E +V  LL+ G
Sbjct: 593 GWTPLHLAAYKGHLEI---IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCG 649

Query: 856 ASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVV 915
           A     ++ G+TPL LA        V  LL++ A++ A++ +   TP  LA   G   ++
Sbjct: 650 ADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN-KVGWTPAHLAALKGNTAIL 708

Query: 916 ELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 967
           ++L+  GA  + ++    TPL LA       I+  L      + +  GSK G
Sbjct: 709 KVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGSKPG 760



 Score = 78.2 bits (191), Expect = 9e-14
 Identities = 57/173 (32%), Positives = 82/173 (47%), Gaps = 2/173 (1%)

Query: 997  IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1056
            I  N+ T L     QG  E V LLL  + +V+ +  +G TPL+ AA     ++  +LL  
Sbjct: 358  IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417

Query: 1057 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD 1116
            GAD N   V       L  AA  G      LL+  GA +D + ++G TPL LAA     +
Sbjct: 418  GADANR--VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475

Query: 1117 VVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMR 1169
            V +LLV   AD +  +    TPL  A   GHV +V+ L  +  +  +    +R
Sbjct: 476  VARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR 528


>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
          Length = 1119

 Score =  160 bits (406), Expect = 1e-38
 Identities = 157/563 (27%), Positives = 250/563 (44%), Gaps = 32/563 (5%)

Query: 185 GKLSTADGKAFAD-PEVLRRLTSSVSCALDEAAAALTRM-RAESTANAGQSDNRSLAEAC 242
           G+     G  + D P+       S+    + +A  L    + +        D   L  A 
Sbjct: 12  GEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAA 71

Query: 243 SEGDVNAVRKLLIEG--RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
           +EG +  + K+  +     ++E  + G + L  A      E  + LL+  AN   R    
Sbjct: 72  AEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNM 131

Query: 301 DITPLMAAANGGHVKIVKLLLAHKA-DVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS 359
            + PL  A  G + +++K+LL H+  DVN +   GNTA+  AC     + +++LL+ GA 
Sbjct: 132 -MAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAK 190

Query: 360 IEDHNENGHTPLMEAGSAGHVEVARLLL----ENGAGINTH---SNEFKESALTLACYKG 412
               N+ G  P+ +A  +G  E   ++L    E+G     H    N  K + L LA   G
Sbjct: 191 PCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNG 250

Query: 413 HLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ----VNMPADSFE 468
            LEM++  L+ GA  +       TA+  A   G  E+ +L++ S +     VN      E
Sbjct: 251 DLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHE 310

Query: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
           + L  A+   H ELA  LI  GA + +++ EG +PL+ A       +V LLL +GA ++ 
Sbjct: 311 TMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDI 370

Query: 529 QTEETQE-TALTLACCGGFLEVADFLIKAGADIEL-------GCSTPLMEAAQEGHLELV 580
           +    +    LT+    G   +    ++     EL       GC TPL  A ++G    V
Sbjct: 371 KDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGC-TPLHYACRQGGPGSV 429

Query: 581 KYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG---GRTPLMKA 637
             LL    ++H+ +    + L +A   G  +    LLQ  +D    +EG   G TPL  A
Sbjct: 430 NNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLA 489

Query: 638 ARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRL-KD 696
           A+ GH   VQ L+ KGA     + +N  T L  A  GG+   ++++L      T RL +D
Sbjct: 490 AKNGHDKVVQLLLKKGALF--LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDED 547

Query: 697 GSTMLIEAAKGGHTSVVCYLLDY 719
           G+T L  AA+ GH   V  LL +
Sbjct: 548 GNTALHFAAREGHAKAVALLLSH 570



 Score =  105 bits (262), Expect = 5e-22
 Identities = 142/571 (24%), Positives = 224/571 (39%), Gaps = 55/571 (9%)

Query: 571  AAQEGHLELVKYLLAAGAN--VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 628
            AA EG +EL++ +    +   +H     G+T L  A E    +    LL  GA+    + 
Sbjct: 70   AAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNF 129

Query: 629  GGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
                PL  A +  +   ++ L+            N +T + +AC   +   +++LL  GA
Sbjct: 130  NMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGA 189

Query: 689  DPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVP 748
             P    K G   + +AA  G    +  +L +                   H  +R   + 
Sbjct: 190  KPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEE----------------HGYSRQLHIN 233

Query: 749  V----QALPMVVPPQEPDKPPANVATTLPIRNKAVS-GRASAMSNTPTHSIAASISQPQT 803
                 +A P+ +  Q  D     +      +   V  GR +A+    T      +     
Sbjct: 234  FMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVK---- 289

Query: 804  PTPSPIISPSAMLPIYP-AIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRD 862
                       M+  Y  ++DI   T+  H+T L  A    H EL   L+  GA I   D
Sbjct: 290  ----------LMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKID 339

Query: 863  KKGFTPLILAATAGHVGVVEILLDNGADIEAQS-------ERTKDTPLSLACSGGRQEVV 915
             +G +PLILA  +    +V +LL  GA ++ +          T   P  L     R E +
Sbjct: 340  SEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL--KNLRPEFM 397

Query: 916  ELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAA 975
            ++   +    +  N    TPL  A   G    +  LL     I+S++  K   SPL  AA
Sbjct: 398  QMQQIKELVMDEDN-DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKK--SPLHFAA 454

Query: 976  MNGHTAAVKLLLDMGSDINAQIETNRN--TALTLACFQGRTEVVSLLLDRKANVEHRAKT 1033
              G     + LL   SD     E + +  T L LA   G  +VV LLL +K  +      
Sbjct: 455  SYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLL-KKGALFLSDHN 513

Query: 1034 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1093
            G T L  A+ GGY +  +V+LD         +    +TAL  AA +GH K   LL+   A
Sbjct: 514  GWTALHHASMGGYTQTMKVILDTNLKC-TDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572

Query: 1094 HIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1124
             I V NK+  + L LA +    +VV  ++++
Sbjct: 573  DI-VLNKQQASFLHLALHNKRKEVVLTIIRS 602



 Score =  101 bits (251), Expect = 1e-20
 Identities = 98/367 (26%), Positives = 167/367 (45%), Gaps = 35/367 (9%)

Query: 822  IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 881
            ID++ + E N +TA+ +AC   + E +Q LL++GA     +K G  P+  AA +G    +
Sbjct: 156  IDVNLEGE-NGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECM 214

Query: 882  EILLDNGADIEAQSE-------RTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYT 934
            EI+L  G +     +         K TPL LA   G  E++++ L  GA  +       T
Sbjct: 215  EIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCT 274

Query: 935  PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML--AAMNGHTAAVKLLLDMGSD 992
             +  AA+ G   I+K+++++ +       +  G    ML  A++  H      L+ +G+D
Sbjct: 275  AIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGAD 334

Query: 993  INAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA----- 1047
            IN +I++   + L LA       +V+LLL + A V+ +   G   L       Y      
Sbjct: 335  IN-KIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLR 393

Query: 1048 -------EVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNK 1100
                   ++  +++D+  D   P         L  A  +G       L+G    I  ++K
Sbjct: 394  PEFMQMQQIKELVMDEDNDGCTP---------LHYACRQGGPGSVNNLLGFNVSIHSKSK 444

Query: 1101 KGNTPLWLAANGGHLDVVQLLVQAGAD---VDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
               +PL  AA+ G ++  Q L+Q  +D   ++  D   +TPL  A + GH KVV+ L+K+
Sbjct: 445  DKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK 504

Query: 1158 VNQFPSD 1164
               F SD
Sbjct: 505  GALFLSD 511



 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 86/322 (26%), Positives = 144/322 (44%), Gaps = 44/322 (13%)

Query: 821  AIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 880
            ++++  + +   +T L  A      E V+ LL RGA+   R+     PL +A    +  V
Sbjct: 87   SLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEV 146

Query: 881  VEILLDNGA-DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLA 939
            +++LL++   D+  + E   +T + +AC+    E +++LL +GA     N     P+  A
Sbjct: 147  MKVLLEHRTIDVNLEGENG-NTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQA 205

Query: 940  ASGGYVNIIKILLNAGAE--------INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS 991
            A  G    ++I+L  G E        IN     K   +PL LA  NG    +K+ LD G+
Sbjct: 206  AFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA--TPLHLAVQNGDLEMIKMCLDNGA 263

Query: 992  DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1051
             I+  +E  R TA+  A  QG TE+V L++         + +G   ++    G +     
Sbjct: 264  QIDP-VEKGRCTAIHFAATQGATEIVKLMIS--------SYSGSVDIVNTTDGCH----- 309

Query: 1052 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1111
                              +T L  A+   H++  + LI  GA I+  + +G +PL LA  
Sbjct: 310  ------------------ETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351

Query: 1112 GGHLDVVQLLVQAGADVDAADN 1133
                ++V LL+  GA VD  DN
Sbjct: 352  SASWNIVNLLLSKGAQVDIKDN 373



 Score = 86.7 bits (213), Expect = 3e-16
 Identities = 77/301 (25%), Positives = 140/301 (46%), Gaps = 21/301 (6%)

Query: 872  AATAGHVGVVE-ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930
            AA  G + ++E I  D+  ++  + +   +TPL  A    + E V+ LL+RGAN   RN 
Sbjct: 70   AAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNF 129

Query: 931  SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 990
            +   PL +A  G    ++K+LL     I+     + G + +++A    ++ A+++LL  G
Sbjct: 130  NMMAPLHIAVQGMNNEVMKVLLE-HRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKG 188

Query: 991  SDINAQIETNRNTALTL--ACFQGRTEVVSLLL--------DRKANVEHRAKTGLTPLME 1040
            +      ++N+     +  A F G  E + ++L         R+ ++        TPL  
Sbjct: 189  A---KPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHL 245

Query: 1041 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR-GAHIDVRN 1099
            A   G  E+ ++ LD GA ++  PV   R TA+  AA +G  +  +L+I      +D+ N
Sbjct: 246  AVQNGDLEMIKMCLDNGAQID--PVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVN 303

Query: 1100 KKG---NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
                   T L  A+   H ++   L+  GAD++  D+   +PL+ A       +V  L+ 
Sbjct: 304  TTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLS 363

Query: 1157 E 1157
            +
Sbjct: 364  K 364



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 100/437 (22%), Positives = 162/437 (37%), Gaps = 91/437 (20%)

Query: 213 DEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLC 272
           +E    L   R       G++ N ++  AC+  +  A++ LL +G    +  + G   + 
Sbjct: 144 NEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIH 203

Query: 273 LACSAGYYELAQVLLA----------MHANVEDRGIKGDITPLMAAANGGHVKIVKLLLA 322
            A  +G  E  +++L           +H N  + G     TPL  A   G ++++K+ L 
Sbjct: 204 QAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNG---KATPLHLAVQNGDLEMIKMCLD 260

Query: 323 HKADVNAQSSTGNTALTYACAGGYVDVVKVLLES---GASIEDHNENGH-TPLMEAGSAG 378
           + A ++       TA+ +A   G  ++VK+++ S      I +  +  H T L  A    
Sbjct: 261 NGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFD 320

Query: 379 HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKT------- 431
           H E+A  L+  GA IN   +E + S L LA       +V  LL  GA  + K        
Sbjct: 321 HHELADYLISVGADINKIDSEGR-SPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFL 379

Query: 432 ----------------------------DEMH---TALMEACMDGHVEVARLLLDSGAQV 460
                                       DE +   T L  AC  G       LL     +
Sbjct: 380 HLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSI 439

Query: 461 NMPADSFESPLTLAACGGHVELAALLIERGASLEEVND---EGYTPLMEAAREGHEEMVA 517
           +  +   +SPL  AA  G +     L++  +    +N+    G TPL  AA+ GH+++V 
Sbjct: 440 HSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQ 499

Query: 518 LLLGQGA--------------------------------NINAQTEETQETALTLACCGG 545
           LLL +GA                                    + +E   TAL  A   G
Sbjct: 500 LLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREG 559

Query: 546 FLEVADFLIKAGADIEL 562
             +    L+   ADI L
Sbjct: 560 HAKAVALLLSHNADIVL 576



 Score = 71.6 bits (174), Expect = 8e-12
 Identities = 81/345 (23%), Positives = 145/345 (42%), Gaps = 47/345 (13%)

Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
           A   GD+  ++  L  G  ++   +   + +  A + G  E+ +++++ ++   D     
Sbjct: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305

Query: 301 D---ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
           D    T L  A+   H ++   L++  AD+N   S G + L  A A    ++V +LL  G
Sbjct: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365

Query: 358 ASIE--------------------------------------DHNENGHTPLMEAGSAGH 379
           A ++                                      D + +G TPL  A   G 
Sbjct: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGG 425

Query: 380 VEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD-EMH--T 436
                 LL     I++ S + K+S L  A   G +   + LL+  +D     + ++H  T
Sbjct: 426 PGSVNNLLGFNVSIHSKSKD-KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484

Query: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASL-EE 495
            L  A  +GH +V +LLL  GA      + + + L  A+ GG+ +   ++++      + 
Sbjct: 485 PLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTA-LHHASMGGYTQTMKVILDTNLKCTDR 543

Query: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
           ++++G T L  AAREGH + VALLL   A+I    ++     L L
Sbjct: 544 LDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLAL 588


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score =  157 bits (398), Expect = 9e-38
 Identities = 124/393 (31%), Positives = 194/393 (49%), Gaps = 53/393 (13%)

Query: 313  HVKIVKLLLAHKADVNAQSSTGNTA--LTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
            +VK+ +LL+   A+VN ++   N A  L      G+ +VV +LLE GA ++  +ENG T 
Sbjct: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963

Query: 371  LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA----GAD 426
            L  A +AGH+++  LL + G  ++ H ++  + AL  +  +GH +++++LL      G  
Sbjct: 964  LCYAAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022

Query: 427  QE---HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGG 478
            Q     K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G
Sbjct: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082

Query: 479  HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538
             +E+  LL+  GA++   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +    
Sbjct: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR---- 1138

Query: 539  TLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
                                       TPLM AA EGHL  V++LL+ GA + +    G 
Sbjct: 1139 ---------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1171

Query: 599  TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
            +AL++AC  GH  V   L++ GA ++   + GRTPL  AA  G   TV +L+ KGA +  
Sbjct: 1172 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1231

Query: 659  TTANNDHT---VLSLACAGGHLAVVELLLAHGA 688
                 DH+    L  A    + +VV  LL  GA
Sbjct: 1232 V----DHSGMRPLDRAIGCRNTSVVVALLRKGA 1260



 Score =  140 bits (352), Expect = 2e-32
 Identities = 103/325 (31%), Positives = 161/325 (49%), Gaps = 17/325 (5%)

Query: 410  YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 467
            Y  ++++ R L+  GA+  ++T+ ++ A +       GH EV  LLL+ GA ++  +++ 
Sbjct: 901  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960

Query: 468  ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL------G 521
             + L  AA  GH++L  LL ++G  ++ ++ +G   L+ +A  GH +++  LL      G
Sbjct: 961  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020

Query: 522  QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS--------TPLMEAAQ 573
                   +     + ALT A   G   V   L+    + E+  +        T L  AA 
Sbjct: 1021 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1080

Query: 574  EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 633
             G LE+ + LL  GA V  T   G   L  A   GH  +  +LL+ G D+    + GRTP
Sbjct: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140

Query: 634  LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693
            LM AA  GH+ TV+FL+SKGA ++ +      + LS AC  GH AVV+ L+  GA     
Sbjct: 1141 LMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQT 1199

Query: 694  LKDGSTMLIEAAKGGHTSVVCYLLD 718
             K+G T L  AA  G    V YL++
Sbjct: 1200 DKNGRTPLDLAAFYGDAETVLYLVE 1224



 Score =  136 bits (342), Expect = 3e-31
 Identities = 140/530 (26%), Positives = 228/530 (43%), Gaps = 40/530 (7%)

Query: 112  SSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTV-DPE 170
            ++ + + E+  +D ++ +  +  F++ + D        + +  L   ADG +   + +P 
Sbjct: 770  NAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPR 829

Query: 171  TQARLEALLEAAGIGKLSTAD----GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAES 226
                L A + +   GKL+       G       + + L+     +     A       E 
Sbjct: 830  NGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEG 889

Query: 227  TANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTE--EGESLLCLACSAGYYELAQ 284
             + A  +  R+L       +V   R L++ G +VN  TE      +LC+    G+ E+  
Sbjct: 890  LS-AALASLRNLYTP----NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVT 944

Query: 285  VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344
            +LL   A ++     G +T L  AA  GH+K+V LL      V+     G  AL ++   
Sbjct: 945  LLLEFGACLDGTSENG-MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALR 1003

Query: 345  GYVDVVKVLL---------ESGASIEDHNENGHTPLMEAGSAGHVEVARLLL----ENGA 391
            G+ D+++ LL         + G   + H       L  A S GH  V + LL    E+  
Sbjct: 1004 GHGDILQYLLTCEWSPGPPQPGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEV 1061

Query: 392  GINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 451
             +N     + E+ALT A  +G LE+   LL  GA            L  A   GH ++ R
Sbjct: 1062 EVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1121

Query: 452  LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREG 511
            LLL+ G  VN+      +PL +AAC GH+     L+ +GA+L  ++ EG + L  A  +G
Sbjct: 1122 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1181

Query: 512  HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPL 568
            H  +V  L+ +GA I+ QT++   T L LA   G  E   +L++ GA IE        PL
Sbjct: 1182 HRAVVQYLVEEGAAID-QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1240

Query: 569  MEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
              A    +  +V  LL  GA +      G+ A  +A      D+  +LLQ
Sbjct: 1241 DRAIGCRNTSVVVALLRKGAKL------GNAA--WAMATSKPDILIILLQ 1282



 Score =  128 bits (322), Expect = 6e-29
 Identities = 144/524 (27%), Positives = 218/524 (41%), Gaps = 73/524 (13%)

Query: 764  PPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAID 823
            P   V+  L +    V+ R   ++N P   + + +   +  T         +L     +D
Sbjct: 903  PNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVT--------LLLEFGACLD 954

Query: 824  IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 883
                T  N  TAL  A A GH +LV  L ++G  ++H DKKG   L+ +A  GH  +++ 
Sbjct: 955  ---GTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1011

Query: 884  LLD------NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR---NVSDY- 933
            LL              +        L+ A S G   VV+ LL  G  KEH    N +D  
Sbjct: 1012 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTL 1069

Query: 934  ---TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 990
               T L+ AA  G + + ++LL  GA + SRT  + G+ PL  AA               
Sbjct: 1070 WGETALTAAAGRGKLEVCELLLGHGAAV-SRTNRR-GVPPLFCAAR-------------- 1113

Query: 991  SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1050
                                QG  ++V LLL+R  +V    K G TPLM AA  G+    
Sbjct: 1114 --------------------QGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTV 1153

Query: 1051 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAA 1110
              LL KGA +++  +     +AL+ A  KGH    + L+  GA ID  +K G TPL LAA
Sbjct: 1154 EFLLSKGAALSS--LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAA 1211

Query: 1111 NGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRY 1170
              G  + V  LV+ GA ++  D+  + PL  A    +  VV  L+++  +  + +  M  
Sbjct: 1212 FYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAM-- 1269

Query: 1171 IATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESR-------R 1223
              +  D  ++    L  E  V  K  +  EA +     L +   E   E+ R        
Sbjct: 1270 ATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGFGEDMRPFNELRVS 1329

Query: 1224 LALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEK 1267
            L L   R +RK       EE   K  E++ K+ E F  +A  ++
Sbjct: 1330 LYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKR 1373


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score =  157 bits (398), Expect = 9e-38
 Identities = 124/393 (31%), Positives = 194/393 (49%), Gaps = 53/393 (13%)

Query: 313  HVKIVKLLLAHKADVNAQSSTGNTA--LTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
            +VK+ +LL+   A+VN ++   N A  L      G+ +VV +LLE GA ++  +ENG T 
Sbjct: 912  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971

Query: 371  LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA----GAD 426
            L  A +AGH+++  LL + G  ++ H ++  + AL  +  +GH +++++LL      G  
Sbjct: 972  LCYAAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030

Query: 427  QE---HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGG 478
            Q     K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G
Sbjct: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090

Query: 479  HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538
             +E+  LL+  GA++   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +    
Sbjct: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR---- 1146

Query: 539  TLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
                                       TPLM AA EGHL  V++LL+ GA + +    G 
Sbjct: 1147 ---------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1179

Query: 599  TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
            +AL++AC  GH  V   L++ GA ++   + GRTPL  AA  G   TV +L+ KGA +  
Sbjct: 1180 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1239

Query: 659  TTANNDHT---VLSLACAGGHLAVVELLLAHGA 688
                 DH+    L  A    + +VV  LL  GA
Sbjct: 1240 V----DHSGMRPLDRAIGCRNTSVVVALLRKGA 1268



 Score =  140 bits (352), Expect = 2e-32
 Identities = 103/325 (31%), Positives = 161/325 (49%), Gaps = 17/325 (5%)

Query: 410  YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 467
            Y  ++++ R L+  GA+  ++T+ ++ A +       GH EV  LLL+ GA ++  +++ 
Sbjct: 909  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 968

Query: 468  ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL------G 521
             + L  AA  GH++L  LL ++G  ++ ++ +G   L+ +A  GH +++  LL      G
Sbjct: 969  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1028

Query: 522  QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS--------TPLMEAAQ 573
                   +     + ALT A   G   V   L+    + E+  +        T L  AA 
Sbjct: 1029 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1088

Query: 574  EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 633
             G LE+ + LL  GA V  T   G   L  A   GH  +  +LL+ G D+    + GRTP
Sbjct: 1089 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1148

Query: 634  LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693
            LM AA  GH+ TV+FL+SKGA ++ +      + LS AC  GH AVV+ L+  GA     
Sbjct: 1149 LMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQT 1207

Query: 694  LKDGSTMLIEAAKGGHTSVVCYLLD 718
             K+G T L  AA  G    V YL++
Sbjct: 1208 DKNGRTPLDLAAFYGDAETVLYLVE 1232



 Score =  136 bits (342), Expect = 3e-31
 Identities = 140/530 (26%), Positives = 228/530 (43%), Gaps = 40/530 (7%)

Query: 112  SSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTV-DPE 170
            ++ + + E+  +D ++ +  +  F++ + D        + +  L   ADG +   + +P 
Sbjct: 778  NAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPR 837

Query: 171  TQARLEALLEAAGIGKLSTAD----GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAES 226
                L A + +   GKL+       G       + + L+     +     A       E 
Sbjct: 838  NGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEG 897

Query: 227  TANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTE--EGESLLCLACSAGYYELAQ 284
             + A  +  R+L       +V   R L++ G +VN  TE      +LC+    G+ E+  
Sbjct: 898  LS-AALASLRNLYTP----NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVT 952

Query: 285  VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344
            +LL   A ++     G +T L  AA  GH+K+V LL      V+     G  AL ++   
Sbjct: 953  LLLEFGACLDGTSENG-MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALR 1011

Query: 345  GYVDVVKVLL---------ESGASIEDHNENGHTPLMEAGSAGHVEVARLLL----ENGA 391
            G+ D+++ LL         + G   + H       L  A S GH  V + LL    E+  
Sbjct: 1012 GHGDILQYLLTCEWSPGPPQPGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEV 1069

Query: 392  GINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 451
             +N     + E+ALT A  +G LE+   LL  GA            L  A   GH ++ R
Sbjct: 1070 EVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1129

Query: 452  LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREG 511
            LLL+ G  VN+      +PL +AAC GH+     L+ +GA+L  ++ EG + L  A  +G
Sbjct: 1130 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1189

Query: 512  HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPL 568
            H  +V  L+ +GA I+ QT++   T L LA   G  E   +L++ GA IE        PL
Sbjct: 1190 HRAVVQYLVEEGAAID-QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1248

Query: 569  MEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
              A    +  +V  LL  GA +      G+ A  +A      D+  +LLQ
Sbjct: 1249 DRAIGCRNTSVVVALLRKGAKL------GNAA--WAMATSKPDILIILLQ 1290



 Score =  128 bits (322), Expect = 6e-29
 Identities = 144/524 (27%), Positives = 218/524 (41%), Gaps = 73/524 (13%)

Query: 764  PPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAID 823
            P   V+  L +    V+ R   ++N P   + + +   +  T         +L     +D
Sbjct: 911  PNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVT--------LLLEFGACLD 962

Query: 824  IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 883
                T  N  TAL  A A GH +LV  L ++G  ++H DKKG   L+ +A  GH  +++ 
Sbjct: 963  ---GTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1019

Query: 884  LLD------NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR---NVSDY- 933
            LL              +        L+ A S G   VV+ LL  G  KEH    N +D  
Sbjct: 1020 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTL 1077

Query: 934  ---TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 990
               T L+ AA  G + + ++LL  GA + SRT  + G+ PL  AA               
Sbjct: 1078 WGETALTAAAGRGKLEVCELLLGHGAAV-SRTNRR-GVPPLFCAAR-------------- 1121

Query: 991  SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1050
                                QG  ++V LLL+R  +V    K G TPLM AA  G+    
Sbjct: 1122 --------------------QGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTV 1161

Query: 1051 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAA 1110
              LL KGA +++  +     +AL+ A  KGH    + L+  GA ID  +K G TPL LAA
Sbjct: 1162 EFLLSKGAALSS--LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAA 1219

Query: 1111 NGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRY 1170
              G  + V  LV+ GA ++  D+  + PL  A    +  VV  L+++  +  + +  M  
Sbjct: 1220 FYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAM-- 1277

Query: 1171 IATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESR-------R 1223
              +  D  ++    L  E  V  K  +  EA +     L +   E   E+ R        
Sbjct: 1278 ATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGFGEDMRPFNELRVS 1337

Query: 1224 LALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEK 1267
            L L   R +RK       EE   K  E++ K+ E F  +A  ++
Sbjct: 1338 LYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKR 1381



 Score = 32.0 bits (71), Expect = 7.4
 Identities = 66/290 (22%), Positives = 104/290 (35%), Gaps = 47/290 (16%)

Query: 2024 SSQSTPESMLSGK--SSYLPNSDPLHQS-----DTSKAPGFRPPLQRPAPSPSGIVNMDS 2076
            S   TP S  S    SSY+ N     QS           G    L+ P   P G++   S
Sbjct: 1470 SVSPTPRSQPSSSVPSSYIRNLQEGLQSKGRPVSPQSRAGIGKSLREPVAQP-GLLLQPS 1528

Query: 2077 PYGSVTPSSTHLGNFASNISGGQM-------YGPGAPLGGAPAA--ANFNRQHFSPLSLL 2127
                +  +S HLG+  S +  G M         P +P+ G  AA  A    QH       
Sbjct: 1529 KQAQIVKTSQHLGSGQSAVRNGSMKVQISSQNPPPSPMPGRIAATPAGSRTQHLEGTGTF 1588

Query: 2128 TPCSSASNDSSAQSVSSGVRA---------PSPAPSSVPLGSEKPSNVSQDRKVPVPIGT 2178
            T  +   +       S  VR          P P+ +         S+V+ D   P   G 
Sbjct: 1589 TTRAGCGHFGDRLGPSQNVRLQCGENGPAHPLPSKTKTTERLLSHSSVAVDAAPPNQGGL 1648

Query: 2179 ERSARIR---------QTGTSAPSVIGSNLSTSVGHSGIWS--FEGIGGN---QDKVDWC 2224
               + +R          +G+ + S+  S+ ++S+  S  +S  F+  G +   +DKV   
Sbjct: 1649 ATCSDVRHPASLTSSGSSGSPSSSIKMSSSTSSLTSSSSFSDGFKVQGPDTRIKDKV--V 1706

Query: 2225 NPGMGNPMIHRPMSDP--GVFSQHQAMERDSTGIVTPSGTFHQHVPAGYM 2272
                     HRP + P  G+  +    ++ S     PS ++H   P G +
Sbjct: 1707 THVQSGTAEHRPRNTPFMGIMDKTARFQQQSN---PPSRSWHCPAPEGLL 1753


>gi|67906195 ankyrin repeat and sterile alpha motif domain containing
            6 [Homo sapiens]
          Length = 871

 Score =  145 bits (367), Expect = 3e-34
 Identities = 116/338 (34%), Positives = 169/338 (50%), Gaps = 26/338 (7%)

Query: 822  IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 881
            + +D   E+ + TAL  A AGGHE LV+ LL RGAS+  R+  G++ L+ AA  GHV V 
Sbjct: 69   VPVDCSDEAGN-TALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVA 127

Query: 882  EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 941
             +LLD+GAD+ AQ+ R   + L++A  GG   VV+LLL  GA  +H + S    L L  S
Sbjct: 128  HLLLDHGADVNAQN-RLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGS 185

Query: 942  GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1001
                                    L I+ LM A  +GH A V+LL++ G+D N    T  
Sbjct: 186  --------------------RDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVG 225

Query: 1002 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061
             + L LA   GR  V   L+++ AN +H +    T    A    + ++    LD    V 
Sbjct: 226  WSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVR 284

Query: 1062 APPVPSSRDTALTIAADKGHYKFC-ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120
                   R   +  A   G+++   E+     +H+++ N  G TPL LAA  G L +VQL
Sbjct: 285  PKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQL 344

Query: 1121 LVQAGADVDAADN-RKITPLMAAFRKGHVKVVRYLVKE 1157
            LV+  ADVD  D+    T LM A   G+ ++V+YL+ +
Sbjct: 345  LVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQ 382



 Score =  125 bits (313), Expect = 6e-28
 Identities = 122/417 (29%), Positives = 183/417 (43%), Gaps = 25/417 (5%)

Query: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYEL---AQVLLAMHANVE 294
           L  AC +GD    R+LL  G +  E  E G      A  AG       A    A+ A V 
Sbjct: 13  LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVP 70

Query: 295 -DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
            D   +   T L  AA GGH  +V+ LL   A VN+++  G +AL  A   G+V V  +L
Sbjct: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130

Query: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE----------- 402
           L+ GA +   N  G + L  A   GH+ V +LLLE GA ++ H    ++           
Sbjct: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190

Query: 403 --SALTLACYKGHLEMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQ 459
             +AL  A   GH  +VR L+E GAD  H    +  + LM A + G + VA+ L++ GA 
Sbjct: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250

Query: 460 VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTP-LMEAAREGHEEMVAL 518
            +  +   ++   +A    H +L   L        + ++E   P +  A + G+ ++V  
Sbjct: 251 PDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKE 310

Query: 519 LLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS----TPLMEAAQE 574
           +  +  +          T L LA   G L +   L++  AD++   S    T LM+A   
Sbjct: 311 IADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYH 370

Query: 575 GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 631
           G+ E+VKYLL  GA+V      G TA          D   V L A   ++   + GR
Sbjct: 371 GNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKGR 427



 Score =  102 bits (253), Expect = 6e-21
 Identities = 108/388 (27%), Positives = 163/388 (42%), Gaps = 29/388 (7%)

Query: 504 LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG 563
           L+ A  +G  E    LL  GA   A+     E     A        A      GA + + 
Sbjct: 13  LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD 72

Query: 564 CS-----TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
           CS     T L  AA  GH  LV++LL  GA+V++    G +AL  A   GH  VA +LL 
Sbjct: 73  CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132

Query: 619 AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANN-------------DH 665
            GAD+  ++  G + L  A+R GH+  V+ L+  GA V+    +              D 
Sbjct: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDI 192

Query: 666 TVLSLACAGGHLAVVELLLAHGADPTHRLKD-GSTMLIEAAKGGHTSVVCYLLDYPNNLL 724
           T L  A   GH AVV LL+  GADP H  +  G + L+ AA  G   V   L++   N  
Sbjct: 193 TALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPD 252

Query: 725 SAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRAS 784
                + T         +R     +  L  V P  + +K   ++   L + N  +    +
Sbjct: 253 HLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIA 312

Query: 785 AMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAI-----DIDAQTESNHDTALTLA 839
                P+H    ++      TP  + + +  L +   +     D+D Q   +  TAL  A
Sbjct: 313 --DEDPSH---VNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQA 367

Query: 840 CAGGHEELVQTLLERGASIEHRDKKGFT 867
              G++E+V+ LL +GA +  R K G+T
Sbjct: 368 TYHGNKEIVKYLLNQGADVTLRAKNGYT 395



 Score =  101 bits (251), Expect = 1e-20
 Identities = 89/306 (29%), Positives = 137/306 (44%), Gaps = 62/306 (20%)

Query: 823  DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKG--------------FTP 868
            D++AQ      + LT+A  GGH  +V+ LLE GA ++H    G               T 
Sbjct: 136  DVNAQNRLGA-SVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITA 194

Query: 869  LILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR 928
            L+ A   GH  VV +L++ GAD    +     +PL LA   GR  V + L+ +GAN +H 
Sbjct: 195  LMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHL 254

Query: 929  NVSDYTPLSLAASGGYVNIIKIL----------------------LNAG----------- 955
            +V + T   +A    + +++  L                      L  G           
Sbjct: 255  SVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADE 314

Query: 956  --AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1013
              + +N   G   G +PLMLAA+ G  A V+LL++  +D++ Q   +  TAL  A + G 
Sbjct: 315  DPSHVNLVNGD--GATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGN 372

Query: 1014 TEVVSLLLDRKANVEHRAKTGLT--PLMEAASGGYAEVGRVLL--------DKGADVNAP 1063
             E+V  LL++ A+V  RAK G T   L+   +    E+ R+L         DKG   + P
Sbjct: 373  KEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKGRPSHQP 432

Query: 1064 PVPSSR 1069
            P+P S+
Sbjct: 433  PLPHSK 438



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 59/156 (37%), Positives = 75/156 (48%), Gaps = 7/156 (4%)

Query: 1005 LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP- 1063
            L  AC QG TE    LL+  A     A+ G  P   A   G    G      GA V AP 
Sbjct: 13   LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAGAEVAGPGAAAAGA-VGAPV 69

Query: 1064 PVPSSRD---TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120
            PV  S +   TAL  AA  GH      L+ RGA ++ RN  G + L  AA  GH+ V  L
Sbjct: 70   PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129

Query: 1121 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
            L+  GADV+A +    + L  A R GH+ VV+ L++
Sbjct: 130  LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLE 165



 Score = 40.4 bits (93), Expect = 0.021
 Identities = 49/165 (29%), Positives = 68/165 (41%), Gaps = 34/165 (20%)

Query: 1676 FPVRPLSPARATNSPK----PHM--------VPRHSNQ--NSSGSQVNS----------- 1710
            FP  P SPA + NS      PH         V RH  +  N SG  +++           
Sbjct: 615  FPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGSIDNVLSQIAAQRKK 674

Query: 1711 -AGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNN 1769
             AG L   P+   SS     PG+S +  P+SP+         ++TS    +  +TT  + 
Sbjct: 675  AAGLLEQKPSHR-SSPVGPAPGSSPSELPASPAGGSAPVGKKLETSKRPPSGTSTT--SK 731

Query: 1770 NTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ---PGGVSRNSPLD 1811
            +T+PT    P P+ K H   SS SS S   Q    GG S  +  D
Sbjct: 732  STSPT--LTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITD 774



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 71/328 (21%), Positives = 115/328 (35%), Gaps = 44/328 (13%)

Query: 1713 SLTSSPTTTTSSSA--STVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTT---AS 1767
            ++ ++P   TS SA     P T  NG  S+   +    +T +  + A  T + +    A 
Sbjct: 498  TMRAAPQDKTSRSALPDAAPVTKDNGPGSTRGEKEDTLLTTMLRNGAPLTRLPSDKLKAV 557

Query: 1768 NNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQE 1827
                 P ++     + +     +  + P   A P   SR  P+  G      V       
Sbjct: 558  IPPFLPPSSFELWSSDRSRTRHNGKADPMKTALPQRASRGHPVGGGGTDTTPVR------ 611

Query: 1828 AGSPPVVETTNTRPPNSSSSSGS--SSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMT 1885
                PV   +  R P SS++SG+   S HS+       VS+     L +S      V   
Sbjct: 612  ----PVKFPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGSIDNVLSQ 667

Query: 1886 VP-------------PLATSSAPVAVPSTAPVTYPMPQTPMGCPQPT-PKMETPAIRPPP 1931
            +              P   SS     P ++P    +P +P G   P   K+ET   + PP
Sbjct: 668  IAAQRKKAAGLLEQKPSHRSSPVGPAPGSSPSE--LPASPAGGSAPVGKKLETS--KRPP 723

Query: 1932 HGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPST--LSTQSACQNSVHPANKP 1989
             GT+   K       S+   L+ +   + H+  SSV   S+   S  S   +S    ++ 
Sbjct: 724  SGTSTTSK-------STSPTLTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDED 776

Query: 1990 IAPNFSAPLPFGPFSTLFENSPTSAHAF 2017
                    L    +  +FE       AF
Sbjct: 777  ELTGILKKLSLEKYQPIFEEQEVDMEAF 804


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score =  142 bits (358), Expect = 4e-33
 Identities = 116/319 (36%), Positives = 155/319 (48%), Gaps = 21/319 (6%)

Query: 843  GHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 902
            G   LV  LL +GAS+E RD  G TPL LA   GH  +V +LL  GA + A  +R   T 
Sbjct: 52   GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAV-DRAGRTA 110

Query: 903  LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE--INS 960
            L  A   G   V ELLL RGA+   R+ +  TPL  AA+ G+  +   LL A       +
Sbjct: 111  LHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAA 170

Query: 961  RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1020
                  G +    AA  G  A ++LL   G+ ++         AL +A   GR   +  L
Sbjct: 171  EAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG--------ALLVAAAAGRGAALRFL 222

Query: 1021 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----TALTIA 1076
            L R A V+ R   G T L  AA+ G ++   VLL  GAD      P  RD    +AL  A
Sbjct: 223  LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGAD------PGIRDRHGRSALHRA 276

Query: 1077 ADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKI 1136
            A +GH    +LL+ +GA +D R+  G TPL  A+  GH++V   L+  GA VDA    + 
Sbjct: 277  AARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK 336

Query: 1137 TPLMAAFRKGHVKVVRYLV 1155
            TPL  A  +GH   V  L+
Sbjct: 337  TPLHLAAERGHGPTVGLLL 355



 Score =  130 bits (328), Expect = 1e-29
 Identities = 117/319 (36%), Positives = 148/319 (46%), Gaps = 14/319 (4%)

Query: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464
           L  A ++G   +V  LL  GA  E +     T L  A + GH  + RLLL  GA V    
Sbjct: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104

Query: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL---G 521
            +  + L  AA  GH  +A LL++RGAS    +  G TPL  AA  GH  + A LL   G
Sbjct: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164

Query: 522 QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVK 581
            G       +    TA   A  GG L V + L   GA    G    L+ AA  G    ++
Sbjct: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGA----GLDGALLVAAAAGRGAALR 220

Query: 582 YLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 641
           +LLA GA V A    G TAL  A   G +   +VLL  GAD       GR+ L +AA  G
Sbjct: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280

Query: 642 HVCTVQFLISKGANVN-RTTANNDHTVLSLACAGGHLAVVELLLAHGA--DPTHRLKDGS 698
           H+  VQ L+++GA V+ R T     T L  A   GH+ V   LL  GA  D T  L+   
Sbjct: 281 HLLAVQLLVTQGAEVDARDTLG--LTPLHHASREGHVEVAGCLLDRGAQVDATGWLR--K 336

Query: 699 TMLIEAAKGGHTSVVCYLL 717
           T L  AA+ GH   V  LL
Sbjct: 337 TPLHLAAERGHGPTVGLLL 355



 Score =  127 bits (320), Expect = 1e-28
 Identities = 108/295 (36%), Positives = 150/295 (50%), Gaps = 15/295 (5%)

Query: 864  KGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGA 923
            +G+  L+ A   G  G+V  LL  GA +E +    + TPL LA   G   +V LLL RGA
Sbjct: 40   QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGR-TPLHLAVLRGHAPLVRLLLQRGA 98

Query: 924  NKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAV 983
                 + +  T L  AA  G+  + ++LL  GA   +R+G+  G++PL  AA  GHT   
Sbjct: 99   PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGT--GLTPLHWAAALGHTLLA 156

Query: 984  KLLLDMGSD--INAQIETNRN-TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLME 1040
              LL+        A+ E  R  TA   A   GR  V+ LL    A ++         L+ 
Sbjct: 157  ARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLV 209

Query: 1041 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNK 1100
            AA+ G     R LL +GA V+A     +  TAL +AA  G  +  E+L+G GA   +R++
Sbjct: 210  AAAAGRGAALRFLLARGARVDARDGAGA--TALGLAAALGRSQDIEVLLGHGADPGIRDR 267

Query: 1101 KGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155
             G + L  AA  GHL  VQLLV  GA+VDA D   +TPL  A R+GHV+V   L+
Sbjct: 268  HGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322



 Score =  120 bits (300), Expect = 2e-26
 Identities = 104/292 (35%), Positives = 145/292 (49%), Gaps = 25/292 (8%)

Query: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD----NGA 889
            TAL  A   GH  + + LL+RGAS   R   G TPL  AA  GH  +   LL+      A
Sbjct: 109  TALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPA 168

Query: 890  DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949
              EA+  R   T    A +GGR  V+ELL A GA  +         L +AA+ G    ++
Sbjct: 169  AAEAEDARGW-TAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALR 220

Query: 950  ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009
             LL  GA +++R G+  G + L LAA  G +  +++LL  G+D   +    R+ AL  A 
Sbjct: 221  FLLARGARVDARDGA--GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS-ALHRAA 277

Query: 1010 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1069
             +G    V LL+ + A V+ R   GLTPL  A+  G+ EV   LLD+GA V+A      R
Sbjct: 278  ARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDA--TGWLR 335

Query: 1070 DTALTIAADKGHYKFCELLIGRGAHIDVRNK--------KGNTPLWLAANGG 1113
             T L +AA++GH     LL+ RGA   +R +        +G+ P  L   GG
Sbjct: 336  KTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPELGG 387



 Score =  119 bits (299), Expect = 3e-26
 Identities = 103/297 (34%), Positives = 151/297 (50%), Gaps = 17/297 (5%)

Query: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
            T L LA   GH  LV+ LL+RGA +   D+ G T L  AA  GH  V E+LL  GA   A
Sbjct: 76   TPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAA 135

Query: 894  QSERTKDTPLSLACSGGRQEV-VELLLARG---ANKEHRNVSDYTPLSLAASGGYVNIIK 949
            +S  T  TPL  A + G   +   LL A G   A  E  +   +T    AA+GG + +++
Sbjct: 136  RS-GTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLE 194

Query: 950  ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009
            +L   GA ++           L++AA  G  AA++ LL  G+ ++A+ +    TAL LA 
Sbjct: 195  LLAAGGAGLD---------GALLVAAAAGRGAALRFLLARGARVDAR-DGAGATALGLAA 244

Query: 1010 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1069
              GR++ + +LL   A+   R + G + L  AA+ G+    ++L+ +GA+V+A       
Sbjct: 245  ALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGL- 303

Query: 1070 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1126
             T L  A+ +GH +    L+ RGA +D       TPL LAA  GH   V LL+  GA
Sbjct: 304  -TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359



 Score =  111 bits (278), Expect = 7e-24
 Identities = 101/323 (31%), Positives = 144/323 (44%), Gaps = 30/323 (9%)

Query: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
           L +A   G    V +LL +G SV E    G + L LA   G+  L ++LL   A V    
Sbjct: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104

Query: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
             G  T L  AA  GH ++ +LLL   A   A+S TG T L +A A G+  +   LLE+ 
Sbjct: 105 RAGR-TALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAP 163

Query: 358 ----ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN------------------- 394
               A+ E  +  G T    A + G + V  LL   GAG++                   
Sbjct: 164 GPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLL 223

Query: 395 ------THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVE 448
                    +    +AL LA   G  + +  LL  GAD   +     +AL  A   GH+ 
Sbjct: 224 ARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLL 283

Query: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
             +LL+  GA+V+       +PL  A+  GHVE+A  L++RGA ++       TPL  AA
Sbjct: 284 AVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAA 343

Query: 509 REGHEEMVALLLGQGANINAQTE 531
             GH   V LLL +GA+   +T+
Sbjct: 344 ERGHGPTVGLLLSRGASPTLRTQ 366



 Score =  110 bits (275), Expect = 2e-23
 Identities = 112/342 (32%), Positives = 154/342 (45%), Gaps = 17/342 (4%)

Query: 266 EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKA 325
           +G   L  A   G   L   LL   A+VE+R   G  TPL  A   GH  +V+LLL   A
Sbjct: 40  QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGR-TPLHLAVLRGHAPLVRLLLQRGA 98

Query: 326 DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARL 385
            V A    G TAL  A   G+  V ++LL+ GAS    +  G TPL  A + GH  +A  
Sbjct: 99  PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAAR 158

Query: 386 LLENGAGINTHSNEFKE----SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEA 441
           LLE   G    + E ++    +A   A   G L ++  L   GA        +  AL+ A
Sbjct: 159 LLE-APGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAG-------LDGALLVA 210

Query: 442 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGY 501
              G     R LL  GA+V+    +  + L LAA  G  +   +L+  GA     +  G 
Sbjct: 211 AAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGR 270

Query: 502 TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561
           + L  AA  GH   V LL+ QGA ++A+ +    T L  A   G +EVA  L+  GA ++
Sbjct: 271 SALHRAAARGHLLAVQLLVTQGAEVDAR-DTLGLTPLHHASREGHVEVAGCLLDRGAQVD 329

Query: 562 LG---CSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
                  TPL  AA+ GH   V  LL+ GA+    T   + A
Sbjct: 330 ATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVA 371



 Score =  103 bits (256), Expect = 3e-21
 Identities = 100/328 (30%), Positives = 131/328 (39%), Gaps = 16/328 (4%)

Query: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
           L  A   G   +   LL+ GA +E     GRTPL  A   GH   V+ L+ +GA V    
Sbjct: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104

Query: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
                T L  A   GH  V ELLL  GA    R   G T L  AA  GHT +   LL+ P
Sbjct: 105 RAG-RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAP 163

Query: 721 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS 780
               +A   +  +    +H      R+ V  L                     +   A +
Sbjct: 164 GPGPAAAEAEDARGWTAAHWAAAGGRLAVLEL----------LAAGGAGLDGALLVAAAA 213

Query: 781 GRASAMSNTPTHSIAASISQPQTPTP---SPIISPSAMLPIYPAIDIDAQTESNHD-TAL 836
           GR +A+                  T    +  +  S  + +      D      H  +AL
Sbjct: 214 GRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSAL 273

Query: 837 TLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSE 896
             A A GH   VQ L+ +GA ++ RD  G TPL  A+  GHV V   LLD GA ++A   
Sbjct: 274 HRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGW 333

Query: 897 RTKDTPLSLACSGGRQEVVELLLARGAN 924
             K TPL LA   G    V LLL+RGA+
Sbjct: 334 LRK-TPLHLAAERGHGPTVGLLLSRGAS 360



 Score = 95.1 bits (235), Expect = 7e-19
 Identities = 110/361 (30%), Positives = 153/361 (42%), Gaps = 49/361 (13%)

Query: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDH---TVLSLACAGGHLAVVELLLAHGADP 690
           L++A   G    V  L+ +GA+V       DH   T L LA   GH  +V LLL  GA  
Sbjct: 45  LLQAVWRGPAGLVTQLLRQGASVEE----RDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100

Query: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQ 750
               + G T L EAA  GH+ V   LL       SA     T LTP  H         + 
Sbjct: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRG---ASAAARSGTGLTP-LHWAAALGHTLLA 156

Query: 751 ALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPII 810
           A  +  P   P    A  A      + A +G   A+                        
Sbjct: 157 ARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAV------------------------ 192

Query: 811 SPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLI 870
                      +++ A   +  D AL +A A G    ++ LL RGA ++ RD  G T L 
Sbjct: 193 -----------LELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALG 241

Query: 871 LAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930
           LAA  G    +E+LL +GAD     +R   + L  A + G    V+LL+ +GA  + R+ 
Sbjct: 242 LAAALGRSQDIEVLLGHGAD-PGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDT 300

Query: 931 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 990
              TPL  A+  G+V +   LL+ GA++++ TG  L  +PL LAA  GH   V LLL  G
Sbjct: 301 LGLTPLHHASREGHVEVAGCLLDRGAQVDA-TG-WLRKTPLHLAAERGHGPTVGLLLSRG 358

Query: 991 S 991
           +
Sbjct: 359 A 359



 Score = 78.2 bits (191), Expect = 9e-14
 Identities = 72/228 (31%), Positives = 105/228 (46%), Gaps = 16/228 (7%)

Query: 499 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 558
           +G+  L++A   G   +V  LL QGA++  + +    T L LA   G   +   L++ GA
Sbjct: 40  QGWGHLLQAVWRGPAGLVTQLLRQGASVE-ERDHAGRTPLHLAVLRGHAPLVRLLLQRGA 98

Query: 559 DI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADV 615
            +   +    T L EAA  GH  + + LL  GA+  A + TG T L +A   GHT +A  
Sbjct: 99  PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAAR 158

Query: 616 LLQAG----ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671
           LL+A     A  E E   G T    AA  G +  ++ L + GA ++          L +A
Sbjct: 159 LLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA--------LLVA 210

Query: 672 CAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
            A G  A +  LLA GA    R   G+T L  AA  G +  +  LL +
Sbjct: 211 AAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGH 258



 Score = 71.6 bits (174), Expect = 8e-12
 Identities = 70/214 (32%), Positives = 97/214 (45%), Gaps = 13/214 (6%)

Query: 178 LLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRS 237
           LLEA G        G A A+ E  R  T++   A     A L     E  A  G   + +
Sbjct: 159 LLEAPG-------PGPAAAEAEDARGWTAAHWAAAGGRLAVL-----ELLAAGGAGLDGA 206

Query: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
           L  A + G   A+R LL  G  V+     G + L LA + G  +  +VLL   A+   R 
Sbjct: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266

Query: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
             G  + L  AA  GH+  V+LL+   A+V+A+ + G T L +A   G+V+V   LL+ G
Sbjct: 267 RHGR-SALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRG 325

Query: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGA 391
           A ++       TPL  A   GH     LLL  GA
Sbjct: 326 AQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 42/129 (32%), Positives = 61/129 (47%), Gaps = 2/129 (1%)

Query: 1038 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDV 1097
            L++A   G A +   LL +GA V       +  T L +A  +GH     LL+ RGA +  
Sbjct: 45   LLQAVWRGPAGLVTQLLRQGASVEERD--HAGRTPLHLAVLRGHAPLVRLLLQRGAPVGA 102

Query: 1098 RNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
             ++ G T L  AA  GH  V +LL+Q GA   A     +TPL  A   GH  +   L++ 
Sbjct: 103  VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162

Query: 1158 VNQFPSDSE 1166
                P+ +E
Sbjct: 163  PGPGPAAAE 171


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.126    0.359 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,712,044
Number of Sequences: 37866
Number of extensions: 5545042
Number of successful extensions: 102909
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1135
Number of HSP's successfully gapped in prelim test: 2096
Number of HSP's that attempted gapping in prelim test: 38663
Number of HSP's gapped (non-prelim): 34918
length of query: 2352
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2233
effective length of database: 13,741,464
effective search space: 30684689112
effective search space used: 30684689112
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.