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Search of human proteins with 38683807
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
(2603 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 5134 0.0
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 3129 0.0
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 2855 0.0
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 2833 0.0
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 917 0.0
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 887 0.0
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 256 3e-67
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 249 2e-65
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 249 2e-65
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 249 2e-65
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 232 3e-60
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 228 8e-59
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 228 8e-59
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 228 8e-59
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 228 8e-59
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 228 8e-59
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 184 8e-46
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 175 6e-43
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 172 4e-42
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 167 1e-40
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 167 1e-40
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 166 3e-40
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 164 1e-39
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 164 1e-39
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 160 1e-38
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 160 1e-38
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 157 1e-37
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 157 1e-37
gi|67906195 ankyrin repeat and sterile alpha motif domain contai... 145 4e-34
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 142 4e-33
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 5134 bits (13318), Expect = 0.0
Identities = 2603/2603 (100%), Positives = 2603/2603 (100%)
Query: 1 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL 60
MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
Sbjct: 1 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL 60
Query: 61 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE 120
LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
Sbjct: 61 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE 120
Query: 121 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE 180
DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
Sbjct: 121 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE 180
Query: 181 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE 240
AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
Sbjct: 181 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE 240
Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
Query: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
Query: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
Query: 541 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA
Sbjct: 541 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
Query: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
Query: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP
Sbjct: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
Query: 721 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAAS 780
NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAAS
Sbjct: 721 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAAS 780
Query: 781 KQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHA 840
KQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHA
Sbjct: 781 KQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHA 840
Query: 841 DQLTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQ 900
DQLTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQ
Sbjct: 841 DQLTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQ 900
Query: 901 QQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFAPIQPLAMPQ 960
QQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFAPIQPLAMPQ
Sbjct: 901 QQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFAPIQPLAMPQ 960
Query: 961 ALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLN 1020
ALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLN
Sbjct: 961 ALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLN 1020
Query: 1021 DTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTE 1080
DTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTE
Sbjct: 1021 DTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTE 1080
Query: 1081 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 1140
SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA
Sbjct: 1081 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 1140
Query: 1141 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1200
DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK
Sbjct: 1141 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1200
Query: 1201 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1260
ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC
Sbjct: 1201 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1260
Query: 1261 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320
FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR
Sbjct: 1261 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320
Query: 1321 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1380
DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD
Sbjct: 1321 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1380
Query: 1381 AADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMES 1440
AADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMES
Sbjct: 1381 AADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMES 1440
Query: 1441 IVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLE 1500
IVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLE
Sbjct: 1441 IVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLE 1500
Query: 1501 EIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNN 1560
EIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNN
Sbjct: 1501 EIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNN 1560
Query: 1561 TITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRIS 1620
TITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRIS
Sbjct: 1561 TITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRIS 1620
Query: 1621 SCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETIS 1680
SCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETIS
Sbjct: 1621 SCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETIS 1680
Query: 1681 EGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRV 1740
EGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRV
Sbjct: 1681 EGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRV 1740
Query: 1741 IGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEI 1800
IGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEI
Sbjct: 1741 IGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEI 1800
Query: 1801 DELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSA 1860
DELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSA
Sbjct: 1801 DELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSA 1860
Query: 1861 STHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPA 1920
STHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPA
Sbjct: 1861 STHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPA 1920
Query: 1921 QSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTV 1980
QSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTV
Sbjct: 1921 QSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTV 1980
Query: 1981 PGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPV 2040
PGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPV
Sbjct: 1981 PGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPV 2040
Query: 2041 SSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSG 2100
SSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSG
Sbjct: 2041 SSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSG 2100
Query: 2101 SSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMP 2160
SSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMP
Sbjct: 2101 SSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMP 2160
Query: 2161 QTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQL 2220
QTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQL
Sbjct: 2161 QTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQL 2220
Query: 2221 PSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTP 2280
PSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTP
Sbjct: 2221 PSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTP 2280
Query: 2281 ESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLG 2340
ESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLG
Sbjct: 2281 ESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLG 2340
Query: 2341 NFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAP 2400
NFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAP
Sbjct: 2341 NFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAP 2400
Query: 2401 SPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIW 2460
SPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIW
Sbjct: 2401 SPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIW 2460
Query: 2461 SFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPA 2520
SFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPA
Sbjct: 2461 SFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPA 2520
Query: 2521 GYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENN 2580
GYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENN
Sbjct: 2521 GYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENN 2580
Query: 2581 GPQTVWTGPWAPHMNSVHMNQLG 2603
GPQTVWTGPWAPHMNSVHMNQLG
Sbjct: 2581 GPQTVWTGPWAPHMNSVHMNQLG 2603
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 3129 bits (8113), Expect = 0.0
Identities = 1578/1589 (99%), Positives = 1579/1589 (99%)
Query: 1015 PAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAID 1074
P + TL AVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAID
Sbjct: 764 PPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAID 823
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI
Sbjct: 824 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 883
Query: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG
Sbjct: 884 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 943
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT
Sbjct: 944 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1003
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP
Sbjct: 1004 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1063
Query: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ
Sbjct: 1064 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1123
Query: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1434
AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC
Sbjct: 1124 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1183
Query: 1435 HLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEE 1494
HLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEE
Sbjct: 1184 HLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEE 1243
Query: 1495 QRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGS 1554
QRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGS
Sbjct: 1244 QRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGS 1303
Query: 1555 HGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDS 1614
HGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDS
Sbjct: 1304 HGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDS 1363
Query: 1615 DNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIK 1674
DNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIK
Sbjct: 1364 DNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIK 1423
Query: 1675 LSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPS 1734
LSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPS
Sbjct: 1424 LSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPS 1483
Query: 1735 TVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIK 1794
TVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIK
Sbjct: 1484 TVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIK 1543
Query: 1795 DPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTV 1854
DPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTV
Sbjct: 1544 DPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTV 1603
Query: 1855 PAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFG 1914
PAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFG
Sbjct: 1604 PAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFG 1663
Query: 1915 GTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTS 1974
GTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTS
Sbjct: 1664 GTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTS 1723
Query: 1975 SSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTA 2034
SSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTA
Sbjct: 1724 SSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTA 1783
Query: 2035 KEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPN 2094
KEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPN
Sbjct: 1784 KEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPN 1843
Query: 2095 SSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP 2154
SSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP
Sbjct: 1844 SSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP 1903
Query: 2155 VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSV 2214
VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSV
Sbjct: 1904 VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSV 1963
Query: 2215 PSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVV 2274
PSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVV
Sbjct: 1964 PSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVV 2023
Query: 2275 SSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTP 2334
SSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTP
Sbjct: 2024 SSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTP 2083
Query: 2335 SSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVS 2394
SSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVS
Sbjct: 2084 SSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVS 2143
Query: 2395 SGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSV 2454
SGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSV
Sbjct: 2144 SGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSV 2203
Query: 2455 GHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTF 2514
GHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTF
Sbjct: 2204 GHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTF 2263
Query: 2515 HQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVS 2574
HQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVS
Sbjct: 2264 HQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVS 2323
Query: 2575 SSTENNGPQTVWTGPWAPHMNSVHMNQLG 2603
SSTENNGPQTVWTGPWAPHMNSVHMNQLG
Sbjct: 2324 SSTENNGPQTVWTGPWAPHMNSVHMNQLG 2352
Score = 1539 bits (3984), Expect = 0.0
Identities = 783/793 (98%), Positives = 787/793 (99%), Gaps = 1/793 (0%)
Query: 1 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL 60
MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
Sbjct: 1 MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL 60
Query: 61 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE 120
LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
Sbjct: 61 LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE 120
Query: 121 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE 180
DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
Sbjct: 121 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE 180
Query: 181 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE 240
AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
Sbjct: 181 AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE 240
Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
Query: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
Query: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
Query: 541 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA
Sbjct: 541 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
Query: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
Query: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP
Sbjct: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
Query: 721 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAAS 780
NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKA S
Sbjct: 721 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS 780
Query: 781 KQKSS-SHLPANS 792
+ S+ S+ P +S
Sbjct: 781 GRASAMSNTPTHS 793
Score = 227 bits (578), Expect = 1e-58
Identities = 145/365 (39%), Positives = 204/365 (55%), Gaps = 38/365 (10%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
D++AQ+ S +TALT ACAGG+ ++V+ LLE GASIE ++ G TPL+ A +AGHV V
Sbjct: 326 DVNAQS-STGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVAR 384
Query: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
+LL+NGA I S K++ L+LAC G E+V LL GA++EH+ +T L A
Sbjct: 385 LLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD 444
Query: 1194 GYVNIIKILLNAGAEINS-------------------------RTGSKL------GISPL 1222
G+V + ++LL++GA++N G+ L G +PL
Sbjct: 445 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL 504
Query: 1223 MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1282
M AA GH V LLL G++INAQ E + TALTLAC G EV L+ A++E
Sbjct: 505 MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC 564
Query: 1283 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1342
TPLMEAA G+ E+ + LL GA+V+A ++ DTALT A + GH ++L+
Sbjct: 565 S---TPLMEAAQEGHLELVKYLLAAGANVHA--TTATGDTALTYACENGHTDVADVLLQA 619
Query: 1343 GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD-AADNRKITPLMAAFRKGHVKV 1401
GA ++ ++ G TPL AA GH+ VQ L+ GA+V+ N T L A GH+ V
Sbjct: 620 GADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAV 679
Query: 1402 VRYLV 1406
V L+
Sbjct: 680 VELLL 684
Score = 218 bits (555), Expect = 6e-56
Identities = 132/336 (39%), Positives = 193/336 (57%), Gaps = 10/336 (2%)
Query: 326 DVNAQS-STGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVAR 384
D++AQ+ S +TALT ACAGG+ ++V+ LLE GASIE ++ G TPL+ A +AGHV V
Sbjct: 823 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
Query: 385 LLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD 444
+LL+NGA I S K++ L+LAC G E+V LL GA++EH+ +T L A
Sbjct: 883 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942
Query: 445 GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGASLE-EVNDEGY 501
G+V + ++LL++GA++N S SPL LAA GH LL++ G+ + ++
Sbjct: 943 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1002
Query: 502 TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561
T L A +G E+V+LLL + AN+ + +T T L A GG+ EV L+ GAD+
Sbjct: 1003 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061
Query: 562 L-----GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616
T L AA +GH + + L+ GA++ G+T L A GH DV +L
Sbjct: 1062 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
Query: 617 LQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
+QAGAD++ TPLM A R GHV V++L+ +
Sbjct: 1122 VQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
Score = 203 bits (517), Expect = 2e-51
Identities = 177/563 (31%), Positives = 254/563 (45%), Gaps = 92/563 (16%)
Query: 209 SCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEG- 267
+C AAL R S L EA EG V LL +G ++N TEE
Sbjct: 475 ACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQ 534
Query: 268 ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADV 327
E+ L LAC G+ E+A L+ A++E G TPLM AA GH+++VK LLA A+V
Sbjct: 535 ETALTLACCGGFLEVADFLIKAGADIE----LGCSTPLMEAAQEGHLELVKYLLAAGANV 590
Query: 328 NAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHV------- 380
+A ++TG+TALTYAC G+ DV VLL++GA +E +E G TPLM+A AGHV
Sbjct: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650
Query: 381 ---------------------------EVARLLLENGAGINTHSNEFKESALTLACYKGH 413
V LLL +GA TH + + L A GH
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGAD-PTHRLKDGSTMLIEAAKGGH 709
Query: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473
+V +LL+ + T L D + R+ + + V P + + P +
Sbjct: 710 TSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLN-RAPRVPVQALPMVVPPQEPDKPPANV 768
Query: 474 A--------ACGGHVELAALLIERG--ASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523
A A G + AS+ + +P++ + L +
Sbjct: 769 ATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPS-------AMLPIYPA 821
Query: 524 ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYL 583
+I+AQTE +TALTLAC GG H ELV+ L
Sbjct: 822 IDIDAQTESNHDTALTLACAGG------------------------------HEELVQTL 851
Query: 584 LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR-TPLMKAARAGH 642
L GA++ G T L A GH V ++LL GAD+E +SE + TPL A G
Sbjct: 852 LERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGR 911
Query: 643 VCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRL--KDGSTM 700
V+ L+++GAN +D+T LSLA +GG++ ++++LL GA+ R K G +
Sbjct: 912 QEVVELLLARGANKEHRNV-SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISP 970
Query: 701 LIEAAKGGHTSVVCYLLDYPNNL 723
L+ AA GHT+ V LLD +++
Sbjct: 971 LMLAAMNGHTAAVKLLLDMGSDI 993
Score = 202 bits (515), Expect = 3e-51
Identities = 124/332 (37%), Positives = 192/332 (57%), Gaps = 5/332 (1%)
Query: 1077 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 1136
A + + +L AC+ G V+ LL G S+ ++G + L LA +AG+ + ++LL
Sbjct: 228 ANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287
Query: 1137 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 1196
A++E + + TPL A +GG ++V+LLLA A+ ++ + T L+ A +GGYV
Sbjct: 288 AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYV 347
Query: 1197 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1256
+++K+LL +GA I ++ G +PLM A GH +LLL+ G+ IN + +AL
Sbjct: 348 DVVKVLLESGASIEDH--NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESAL 405
Query: 1257 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316
TLAC++G E+V LL+ A+ EH+ T LMEA G+ EV R+LLD GA VN P
Sbjct: 406 TLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP-- 463
Query: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376
S ++ LT+AA GH + LLI RGA ++ N +G TPL AA GH ++V LL+ G
Sbjct: 464 ADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523
Query: 1377 ADVDA-ADNRKITPLMAAFRKGHVKVVRYLVK 1407
A+++A + + T L A G ++V +L+K
Sbjct: 524 ANINAQTEETQETALTLACCGGFLEVADFLIK 555
Score = 202 bits (515), Expect = 3e-51
Identities = 124/332 (37%), Positives = 192/332 (57%), Gaps = 5/332 (1%)
Query: 228 ANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287
A + + +L AC+ G V+ LL G S+ ++G + L LA +AG+ + ++LL
Sbjct: 826 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885
Query: 288 AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYV 347
A++E + + TPL A +GG ++V+LLLA A+ ++ + T L+ A +GGYV
Sbjct: 886 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 945
Query: 348 DVVKVLLESGASIEDH--NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESAL 405
+++K+LL +GA I ++ G +PLM A GH +LLL+ G+ IN + +AL
Sbjct: 946 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1005
Query: 406 TLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP-- 463
TLAC++G E+V LL+ A+ EH+ T LMEA G+ EV R+LLD GA VN P
Sbjct: 1006 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1065
Query: 464 ADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523
S ++ LT+AA GH + LLI RGA ++ N +G TPL AA GH ++V LL+ G
Sbjct: 1066 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1125
Query: 524 ANINAQTEETQETALTLACCGGFLEVADFLIK 555
A+++A + + T L A G ++V +L+K
Sbjct: 1126 ADVDA-ADNRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 197 bits (501), Expect = 1e-49
Identities = 152/461 (32%), Positives = 236/461 (51%), Gaps = 49/461 (10%)
Query: 994 QLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQ 1053
+ AG+G+ T G A P + L + A+ A+A++ S A+ Q
Sbjct: 180 EAAGIGK---LSTADGKAFADP-EVLRRLTSSVSCALDEAAAALTRMRAES-TANAGQSD 234
Query: 1054 TPTPSPIISPSAMLPIYPAIDIDAQTESNH----DTALTLACAGGHEELVQTLLERGASI 1109
+ + S + + + I+ ++ + H ++ L LAC+ G+ EL Q LL A++
Sbjct: 235 NRSLAEACSEGDVNAVRKLL-IEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 293
Query: 1110 EHRDKKG-FTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVEL 1168
E R KG TPL+ AA GHV +V++LL + AD+ AQS T +T L+ AC+GG +VV++
Sbjct: 294 EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSS-TGNTALTYACAGGYVDVVKV 352
Query: 1169 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTG----SKLGIS---- 1220
LL GA+ E N + +TPL A S G+V + ++LL GA IN+ + S L ++
Sbjct: 353 LLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKG 412
Query: 1221 ------------------------PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1256
LM A M+GH +LLLD G+ +N ++ + L
Sbjct: 413 HLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP-L 471
Query: 1257 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316
TLA G E+ +LL++R A++E G TPLMEAA G+ E+ +LL +GA++NA
Sbjct: 472 TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ-T 530
Query: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376
+++TALT+A G + + LI GA I++ +TPL AA GHL++V+ L+ AG
Sbjct: 531 EETQETALTLACCGGFLEVADFLIKAGADIELGC---STPLMEAAQEGHLELVKYLLAAG 587
Query: 1377 ADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSE 1417
A+V A T L A GH V L++ +SE
Sbjct: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 628
Score = 191 bits (485), Expect = 8e-48
Identities = 160/503 (31%), Positives = 239/503 (47%), Gaps = 50/503 (9%)
Query: 226 STANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQV 285
+TAN +D+ L+ AC+ G + V LL G ++G ++L A G+ +
Sbjct: 659 TTAN---NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCY 715
Query: 286 LLAMHANVEDRGIKGDITPLMAAANGGH------VKIVKLLL------------------ 321
LL N+ D+T L ++ + V+ + +++
Sbjct: 716 LLDYPNNLLSAP-PPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPI 774
Query: 322 ---AHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGA--------SIEDHNENGH-T 369
A +A S+T ++ + + ++ A I+ E+ H T
Sbjct: 775 RNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDT 834
Query: 370 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEH 429
L A + GH E+ + LLE GA I H ++ + L LA GH+ +V LL+ GAD E
Sbjct: 835 ALTLACAGGHEELVQTLLERGASIE-HRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Query: 430 KTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 488
+++ T L AC G EV LLL GA S +PL+LAA GG+V + +L+
Sbjct: 894 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 953
Query: 489 RGASLEEVNDE--GYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGF 546
GA + G +PLM AA GH V LLL G++INAQ E + TALTLAC G
Sbjct: 954 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1013
Query: 547 LEVADFLIKAGADIELGCST---PLMEAAQEGHLELVKYLLAAGANVHA--TTATGDTAL 601
EV L+ A++E T PLMEAA G+ E+ + LL GA+V+A ++ DTAL
Sbjct: 1014 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1073
Query: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661
T A + GH ++L+ GA ++ ++ G TPL AA GH+ VQ L+ GA+V+
Sbjct: 1074 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD-AAD 1132
Query: 662 NNDHTVLSLACAGGHLAVVELLL 684
N T L A GH+ VV L+
Sbjct: 1133 NRKITPLMAAFRKGHVKVVRYLV 1155
Score = 186 bits (471), Expect = 3e-46
Identities = 152/471 (32%), Positives = 235/471 (49%), Gaps = 27/471 (5%)
Query: 426 DQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484
D + +T+ H TAL AC GH E+ + LL+ GA + +PL LAA GHV +
Sbjct: 823 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
Query: 485 LLIERGASLEEVNDEGY-TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACC 543
+L++ GA +E ++ TPL A G +E+V LLL +GAN + T L+LA
Sbjct: 883 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGAN-KEHRNVSDYTPLSLAAS 941
Query: 544 GGFLEVADFLIKAGADI------ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
GG++ + L+ AGA+I +LG S PLM AA GH VK LL G++++A T
Sbjct: 942 GGYVNIIKILLNAGAEINSRTGSKLGIS-PLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1000
Query: 598 -DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANV 656
+TALT AC G T+V +LL A++EH ++ G TPLM+AA G+ + L+ KGA+V
Sbjct: 1001 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1060
Query: 657 NRTTANNDH-TVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCY 715
N + T L++A GH ELL+ GA R K G+T L AA GGH VV
Sbjct: 1061 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120
Query: 716 LLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIR 775
L+ ++ +A D ++TP + V+ L +E ++ P++ I
Sbjct: 1121 LVQAGADVDAA---DNRKITPLMAAFRKGHVKVVRYL-----VKEVNQFPSDSECMRYIA 1172
Query: 776 NKAASKQKSSSHLPANS----QDVQGYITNQSPESIVEEAQ-GKLTELEQRIKEAIEKNA 830
+ HL S +D Q N++ ++EE KL E +R+ A ++
Sbjct: 1173 TITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREK 1232
Query: 831 QLQSLELAHADQLTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQ 881
+ + +Q + K+EE+ +E + + +E KVE E ++ T+
Sbjct: 1233 RKEKRRKKKEEQ--RRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTE 1281
Score = 176 bits (446), Expect = 3e-43
Identities = 122/341 (35%), Positives = 183/341 (53%), Gaps = 16/341 (4%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
+++ T +N T L+LACAGGH +V+ LL GA HR K G T LI AA GH VV
Sbjct: 655 NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
Query: 1134 ILLD--NGADIEAQSERTKDTP----LSLACSGGRQEVVELLLARGANKEHRNVSDYTPL 1187
LLD N + T+ TP L+ A Q + ++ + +K NV+ P+
Sbjct: 715 YLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPI 774
Query: 1188 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 1247
A G + + + SP++ + + L + DI+AQ
Sbjct: 775 RNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPII-------SPSAMLPIYPAIDIDAQ 827
Query: 1248 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1307
E+N +TALTLAC G E+V LL+R A++EHR K G TPL+ AA+ G+ V +LLD
Sbjct: 828 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 887
Query: 1308 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD 1367
GAD+ A ++DT L++A G + ELL+ RGA+ + RN TPL LAA+GG+++
Sbjct: 888 GADIEAQS-ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVN 946
Query: 1368 VVQLLVQAGADVDAADNRK--ITPLMAAFRKGHVKVVRYLV 1406
++++L+ AGA++++ K I+PLM A GH V+ L+
Sbjct: 947 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLL 987
Score = 164 bits (416), Expect = 8e-40
Identities = 103/265 (38%), Positives = 144/265 (54%), Gaps = 34/265 (12%)
Query: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 1143
++ LTLA GGH EL L+ERGAS+E + +G+TPL+ AA GH +V +LL GA+I
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Query: 1144 AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203
AQ+E T++T L+LAC GG EV + L+ GA+ E + TPL AA G++ ++K LL
Sbjct: 528 AQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPLMEAAQEGHLELVKYLL 584
Query: 1204 NAGAEINSRTG-------------------------------SKLGISPLMLAAMNGHTA 1232
AGA +++ T S+ G +PLM AA GH
Sbjct: 585 AAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644
Query: 1233 AVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEA 1292
V+ L+ G+++N N +T L+LAC G VV LLL A+ HR K G T L+EA
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 704
Query: 1293 ASGGYAEVGRVLLDKGADVNAPPVP 1317
A GG+ V LLD ++ + P P
Sbjct: 705 AKGGHTSVVCYLLDYPNNLLSAPPP 729
Score = 160 bits (404), Expect = 2e-38
Identities = 117/331 (35%), Positives = 164/331 (49%), Gaps = 7/331 (2%)
Query: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
T + DTALT AC GH ++ LL+ GA +EH + G TPL+ AA AGHV V+ L+
Sbjct: 593 TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Query: 1139 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNI 1198
GA++ + T LSLAC+GG VVELLLA GA+ HR T L AA GG+ ++
Sbjct: 653 GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
Query: 1199 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL 1258
+ LL+ + S + +N L M + N A TL
Sbjct: 713 VCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTL 772
Query: 1259 ACFQGRTEVVSLLLDRKANV-EHRAKTGLT-PLMEAASGGYAEVGRVLLDKGADVNAPPV 1316
R + VS +N H ++ P S + + + D++A
Sbjct: 773 PI---RNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDA-QT 828
Query: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376
S+ DTALT+A GH + + L+ RGA I+ R+KKG TPL LAA GH+ VV++L+ G
Sbjct: 829 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 888
Query: 1377 ADVDAADNR-KITPLMAAFRKGHVKVVRYLV 1406
AD++A R K TPL A G +VV L+
Sbjct: 889 ADIEAQSERTKDTPLSLACSGGRQEVVELLL 919
Score = 156 bits (395), Expect = 2e-37
Identities = 100/268 (37%), Positives = 147/268 (54%), Gaps = 3/268 (1%)
Query: 224 AESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELA 283
A+ A + ++ + L+ ACS G V LL G + + L LA S GY +
Sbjct: 889 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 948
Query: 284 QVLLAMHANVEDR-GIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTG-NTALTYA 341
++LL A + R G K I+PLM AA GH VKLLL +D+NAQ T NTALT A
Sbjct: 949 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1008
Query: 342 CAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS-NEF 400
C G +VV +LL+ A++E + G TPLMEA S G+ EV R+LL+ GA +N
Sbjct: 1009 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1068
Query: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 460
+++ALT+A KGH + L+ GA + + + +T L A GH++V +LL+ +GA V
Sbjct: 1069 RDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADV 1128
Query: 461 NMPADSFESPLTLAACGGHVELAALLIE 488
+ + +PL A GHV++ L++
Sbjct: 1129 DAADNRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 91.7 bits (226), Expect = 9e-18
Identities = 59/175 (33%), Positives = 91/175 (52%), Gaps = 1/175 (0%)
Query: 215 AAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLA 274
A L M ++ A + N +L AC +G V LL +V + G + L A
Sbjct: 982 AVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEA 1041
Query: 275 CSAGYYELAQVLLAMHANVEDRGIKGD-ITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
S GY E+ +VLL A+V + T L AA+ GH K +LL+ A ++ ++
Sbjct: 1042 ASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKK 1101
Query: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLE 388
GNT L A GG++DVV++L+++GA ++ + TPLM A GHV+V R L++
Sbjct: 1102 GNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 2855 bits (7402), Expect = 0.0
Identities = 1584/2576 (61%), Positives = 1867/2576 (72%), Gaps = 133/2576 (5%)
Query: 78 RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122
RT R + +S +SGGGG G G GGG GGG ++ S+E+E
Sbjct: 42 RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
Query: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182
VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
Query: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 154 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 213
Query: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302
S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 214 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273
Query: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL GA+IED
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
Query: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 514 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
Query: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662
YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH+CTVQFLISKGANVNR TAN
Sbjct: 574 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633
Query: 663 NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722
NDHTV+SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT+VV YLLDYPNN
Sbjct: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693
Query: 723 LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQ 782
+LS P DV+QL PPS D ++ PRVP L MVVPPQEPD+ + L K SKQ
Sbjct: 694 VLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQ 753
Query: 783 KSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQ 842
KSSS A+ + + Q E IVEE +GKL EL QRI AIEK AQL+SLEL +
Sbjct: 754 KSSSLQVADQDLLPSFHPYQPLECIVEETEGKLNELGQRI-SAIEK-AQLKSLELIQGEP 811
Query: 843 LTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQ 902
L K+KIEEL K REEQ+QKK+KIL+ELQKVER+LQ+KTQQQ K+YLE K Q+ + Q
Sbjct: 812 LNKDKIEELKKNREEQVQKKKKILKELQKVERQLQMKTQQQFTKEYLETKGQKDTVSLHQ 871
Query: 903 QQSCQHLGLLTPVGVGE-QLSEGDYARLQQVDPVLLK----DEPQQ---TAAQMGFAPIQ 954
Q C H G+ P G G+ L E ++ L QVD +L K D+ QQ +A Q+ F P+Q
Sbjct: 872 Q--CSHRGVF-PEGEGDGSLPEDHFSELPQVDTILFKDNDVDDEQQSPPSAEQIDFVPVQ 928
Query: 955 PLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLA--GLGQGILTETQQGLMV 1012
PL+ PQ + L N ELQ V Q ++GQ Q+A G QG+L + GLMV
Sbjct: 929 PLSSPQC--NFSSDLGSNG-TNSLELQKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMV 985
Query: 1013 ASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPA 1072
A+PAQTL DTLDD++AAVS R SN+ + + + + T S + S S M P+YP+
Sbjct: 986 ATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQS-MPPVYPS 1044
Query: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132
+DIDA TESNHDTALTLACAGGHEELV L+ R A IEHRDKKGFTPLILAATAGHVGVV
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
Query: 1133 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 1192
EILLD G DIEAQSERTKDTPLSLACSGGRQEVV+LLLARGANKEHRNVSDYTPLSLAAS
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
Query: 1193 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1252
GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH AVKLLLDMGSDINAQIETNR
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
Query: 1253 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312
NTALTLACFQGR EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Query: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372
APPVPSSRDTALTIAADKGHYKFCELLI RGAHIDVRNKKGNTPLWLA+NGGH DVVQLL
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 1373 VQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLK 1432
VQAGADVDAADNRKITPLM+AFRKGHVKVV+YLVKEVNQFPSD ECMRYIATITDKE+LK
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404
Query: 1433 KCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKK 1492
KCH C+E+IV+AKD+QAAEANKNASILL+ELDLEK REESR+ ALAAKREKRKEKR+KKK
Sbjct: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKK 1464
Query: 1493 EEQRRKLEEIEA-KNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTL 1551
EEQ+RK EE E K KEN EL +++E+ + E EV EPPSATTTTTIGISAT T
Sbjct: 1465 EEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATF 1524
Query: 1552 AGSHG-KRNNTITTTSSKRKNRKNKI--TPENVQIIFDD---PLPISYSQPEKVNGESKS 1605
G KR N +TT S+ RKN+KNK TP +I + L + K+NGE +
Sbjct: 1525 TNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILPEQHMSLAQQKADKNKINGEPRG 1584
Query: 1606 SSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERK 1665
+ DSDN+ + C+ ESS+ S++ + V+S K PS+L+ +E+
Sbjct: 1585 GGAGGNSDSDNLDSTDCNSESSSGGKSQELN------FVMDVNSSKYPSLLLHSQEEKTS 1638
Query: 1666 SVSGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVR 1725
+ + K +L E T NSLST K+ PLSSPN KL + SPKRGQKREEGWKEVVR
Sbjct: 1639 TATSKTQTRLE---GEVTPNSLSTSYKTVSLPLSSPNIKLNLTSPKRGQKREEGWKEVVR 1695
Query: 1726 RSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQA 1785
RSKK+SVP++V+SR++GRGGCNI AI++ TGAHID+DKQKDK G+R+ITIRGGTESTR A
Sbjct: 1696 RSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGERMITIRGGTESTRYA 1755
Query: 1786 TQLINALIKDPDKEIDELIPKNRLK----SSSANSKIGSSAPTTTAANTSLMGIKMTTVA 1841
QLINALI+DP KE+++LIPKN ++ + S ++ S TT A++ + + T+
Sbjct: 1756 VQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTAASSKNAFPLGAPTLV 1815
Query: 1842 LSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQ 1901
TSQ T T +K KN NVR FPVSLPLAYP P F ALLAAQT Q
Sbjct: 1816 ---TSQATTLSTF-----QPANKLNKNVPTNVRSSFPVSLPLAYPHPHF--ALLAAQTMQ 1865
Query: 1902 QIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNS 1961
QIR PRLPM FGGTF P+ +TWGPFPVRP++P +SPK + R NQN + S
Sbjct: 1866 QIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTVLPSES 1925
Query: 1962 AGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNN 2021
AG T+S T SS + + + SVR+QLF V KTS T +++ S +
Sbjct: 1926 AGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTS-PPATVISSVTSTCS 1984
Query: 2022 TAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASP---NKVASSSEQE 2078
+ P+ ++ P+ + + +P++ P + + ++ SA P KV++ +
Sbjct: 1985 SLPSVSSAPITSGQ------APTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPM 2038
Query: 2079 AGSPPVVETTNTRPPNSSSSSGSSSAH-SNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTV 2137
A T N+ ++S++ G+ H S+ P S +QE P S + P +
Sbjct: 2039 ANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSM---- 2094
Query: 2138 PPLATSSAPVAVPSTAP--------VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPH 2189
P A++S P + T+P T +PQ + P+ + +M+ P G+
Sbjct: 2095 -PFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQ-------PRGSFYSM 2146
Query: 2190 KNSASVQNSSVAVLSVNHI--KRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSA 2247
+A++ ++ N + P P++VQL S ++ + Q ++PANK + P F
Sbjct: 2147 VPNATIHQDPQSIFVTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGP 2206
Query: 2248 PLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLH----QSDTS 2303
F FS+LF++S A+ WG +SS+ ++ + +S++L NS H D S
Sbjct: 2207 ATLFNHFSSLFDSSQVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNS 2266
Query: 2304 KAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPA 2363
KAPGFRPP QR + SP G+ ++D S + SS L +F S I G +++ G G P
Sbjct: 2267 KAPGFRPPSQRVSTSPVGLPSIDPSGSSPSSSSAPLASF-SGIPGTRVFLQGPAPVGTP- 2324
Query: 2364 AANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKV 2423
+FNRQHFSP P +SASN S++ AP + LG K + SQDRK+
Sbjct: 2325 --SFNRQHFSP----HPWTSASNSSTS------------APPT--LGQPKGVSASQDRKI 2364
Query: 2424 PVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGNPM 2483
P PIGTER ARIRQ G+ A + G++ VGHSGIWSF ++ W MGN
Sbjct: 2365 PPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGIWSFGVNAVSEGLSGWSQSVMGNHP 2424
Query: 2484 IHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPP 2543
+H+ +SDP FSQHQ MERD +G+V PS FHQ + +G++DF K G+P S+YG +IP
Sbjct: 2425 MHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMASGFVDFSK--GLPISMYGGTIIPS 2482
Query: 2544 VAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGPWAPHMNSVHM 2599
+ D GGP+FNG H DP+WN +IK++ +STE Q +W G WAPH+ ++H+
Sbjct: 2483 HPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTDAQQIWPGTWAPHIGNMHL 2538
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 2833 bits (7344), Expect = 0.0
Identities = 1579/2569 (61%), Positives = 1857/2569 (72%), Gaps = 133/2569 (5%)
Query: 78 RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122
RT R + +S +SGGGG G G GGG GGG ++ S+E+E
Sbjct: 42 RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
Query: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182
VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
Query: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 154 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 213
Query: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302
S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 214 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273
Query: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL GA+IED
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
Query: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 514 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
Query: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662
YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH+CTVQFLISKGANVNR TAN
Sbjct: 574 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633
Query: 663 NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722
NDHTV+SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT+VV YLLDYPNN
Sbjct: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693
Query: 723 LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQ 782
+LS P DV+QL PPS D ++ PRVP L MVVPPQEPD+ + L K SKQ
Sbjct: 694 VLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQ 753
Query: 783 KSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQ 842
KSSS A+ + + Q E IVEE +GKL EL QRI AIEK AQL+SLEL +
Sbjct: 754 KSSSLQVADQDLLPSFHPYQPLECIVEETEGKLNELGQRI-SAIEK-AQLKSLELIQGEP 811
Query: 843 LTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQ 902
L K+KIEEL K REEQ+QKK+KIL+ELQKVER+LQ+KTQQQ K+YLE K Q+ + Q
Sbjct: 812 LNKDKIEELKKNREEQVQKKKKILKELQKVERQLQMKTQQQFTKEYLETKGQKDTVSLHQ 871
Query: 903 QQSCQHLGLLTPVGVGE-QLSEGDYARLQQVDPVLLK----DEPQQ---TAAQMGFAPIQ 954
Q C H G+ P G G+ L E ++ L QVD +L K D+ QQ +A Q+ F P+Q
Sbjct: 872 Q--CSHRGVF-PEGEGDGSLPEDHFSELPQVDTILFKDNDVDDEQQSPPSAEQIDFVPVQ 928
Query: 955 PLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLA--GLGQGILTETQQGLMV 1012
PL+ PQ + L N ELQ V Q ++GQ Q+A G QG+L + GLMV
Sbjct: 929 PLSSPQC--NFSSDLGSNG-TNSLELQKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMV 985
Query: 1013 ASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPA 1072
A+PAQTL DTLDD++AAVS R SN+ + + + + T S + S S M P+YP+
Sbjct: 986 ATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQS-MPPVYPS 1044
Query: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132
+DIDA TESNHDTALTLACAGGHEELV L+ R A IEHRDKKGFTPLILAATAGHVGVV
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
Query: 1133 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 1192
EILLD G DIEAQSERTKDTPLSLACSGGRQEVV+LLLARGANKEHRNVSDYTPLSLAAS
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
Query: 1193 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1252
GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH AVKLLLDMGSDINAQIETNR
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
Query: 1253 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312
NTALTLACFQGR EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Query: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372
APPVPSSRDTALTIAADKGHYKFCELLI RGAHIDVRNKKGNTPLWLA+NGGH DVVQLL
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 1373 VQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLK 1432
VQAGADVDAADNRKITPLM+AFRKGHVKVV+YLVKEVNQFPSD ECMRYIATITDKE+LK
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404
Query: 1433 KCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKK 1492
KCH C+E+IV+AKD+QAAEANKNASILL+ELDLEK REESR+ ALAAKREKRKEKR+KKK
Sbjct: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKK 1464
Query: 1493 EEQRRKLEEIEA-KNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTL 1551
EEQ+RK EE E K KEN EL +++E+ + E EV EPPSATTTTTIGISAT T
Sbjct: 1465 EEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATF 1524
Query: 1552 AGSHG-KRNNTITTTSSKRKNRKNKI--TPENVQIIFDD---PLPISYSQPEKVNGESKS 1605
G KR N +TT S+ RKN+KNK TP +I + L + K+NGE +
Sbjct: 1525 TNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILPEQHMSLAQQKADKNKINGEPRG 1584
Query: 1606 SSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERK 1665
+ DSDN+ + C+ ESS+ S++ + V+S K PS+L+ +E+
Sbjct: 1585 GGAGGNSDSDNLDSTDCNSESSSGGKSQELN------FVMDVNSSKYPSLLLHSQEEKTS 1638
Query: 1666 SVSGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVR 1725
+ + K +L E T NSLST K+ PLSSPN KL + SPKRGQKREEGWKEVVR
Sbjct: 1639 TATSKTQTRLE---GEVTPNSLSTSYKTVSLPLSSPNIKLNLTSPKRGQKREEGWKEVVR 1695
Query: 1726 RSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQA 1785
RSKK+SVP++V+SR++GRGGCNI AI++ TGAHID+DKQKDK G+R+ITIRGGTESTR A
Sbjct: 1696 RSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGERMITIRGGTESTRYA 1755
Query: 1786 TQLINALIKDPDKEIDELIPKNRLK----SSSANSKIGSSAPTTTAANTSLMGIKMTTVA 1841
QLINALI+DP KE+++LIPKN ++ + S ++ S TT A++ + + T+
Sbjct: 1756 VQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTAASSKNAFPLGAPTLV 1815
Query: 1842 LSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQ 1901
TSQ T T +K KN NVR FPVSLPLAYP P F ALLAAQT Q
Sbjct: 1816 ---TSQATTLSTF-----QPANKLNKNVPTNVRSSFPVSLPLAYPHPHF--ALLAAQTMQ 1865
Query: 1902 QIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNS 1961
QIR PRLPM FGGTF P+ +TWGPFPVRP++P +SPK + R NQN + S
Sbjct: 1866 QIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTVLPSES 1925
Query: 1962 AGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNN 2021
AG T+S T SS + + + SVR+QLF V KTS T +++ S +
Sbjct: 1926 AGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTS-PPATVISSVTSTCS 1984
Query: 2022 TAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASP---NKVASSSEQE 2078
+ P+ ++ P+ + + +P++ P + + ++ SA P KV++ +
Sbjct: 1985 SLPSVSSAPITSGQ------APTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPM 2038
Query: 2079 AGSPPVVETTNTRPPNSSSSSGSSSAH-SNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTV 2137
A T N+ ++S++ G+ H S+ P S +QE P S + P +
Sbjct: 2039 ANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSM---- 2094
Query: 2138 PPLATSSAPVAVPSTAP--------VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPH 2189
P A++S P + T+P T +PQ + P+ + +M+ P G+
Sbjct: 2095 -PFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQ-------PRGSFYSM 2146
Query: 2190 KNSASVQNSSVAVLSVNHI--KRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSA 2247
+A++ ++ N + P P++VQL S ++ + Q ++PANK + P F
Sbjct: 2147 VPNATIHQDPQSIFVTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGP 2206
Query: 2248 PLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLH----QSDTS 2303
F FS+LF++S A+ WG +SS+ ++ + +S++L NS H D S
Sbjct: 2207 ATLFNHFSSLFDSSQVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNS 2266
Query: 2304 KAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPA 2363
KAPGFRPP QR + SP G+ ++D S + SS L +F S I G +++ G G P
Sbjct: 2267 KAPGFRPPSQRVSTSPVGLPSIDPSGSSPSSSSAPLASF-SGIPGTRVFLQGPAPVGTP- 2324
Query: 2364 AANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKV 2423
+FNRQHFSP P +SASN S++ AP + LG K + SQDRK+
Sbjct: 2325 --SFNRQHFSP----HPWTSASNSSTS------------APPT--LGQPKGVSASQDRKI 2364
Query: 2424 PVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGNPM 2483
P PIGTER ARIRQ G+ A + G++ VGHSGIWSF ++ W MGN
Sbjct: 2365 PPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGIWSFGVNAVSEGLSGWSQSVMGNHP 2424
Query: 2484 IHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPP 2543
+H+ +SDP FSQHQ MERD +G+V PS FHQ + +G++DF K G+P S+YG +IP
Sbjct: 2425 MHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMASGFVDFSK--GLPISMYGGTIIPS 2482
Query: 2544 VAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGPWAP 2592
+ D GGP+FNG H DP+WN +IK++ +STE Q P P
Sbjct: 2483 HPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTDAQQASLLPSVP 2531
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 917 bits (2370), Expect = 0.0
Identities = 479/586 (81%), Positives = 516/586 (88%), Gaps = 24/586 (4%)
Query: 78 RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122
RT R + +S +SGGGG G G GGG GGG ++ S+E+E
Sbjct: 42 RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
Query: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182
VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
Query: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 154 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 213
Query: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302
S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 214 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273
Query: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL GA+IED
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
Query: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 514 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
Query: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648
YACENGHTDVADVLLQAGADL+ + E +T L A H V F
Sbjct: 574 YACENGHTDVADVLLQAGADLD-KQEDMKTILEGIDPAKHQVRVAF 618
Score = 246 bits (628), Expect = 2e-64
Identities = 150/370 (40%), Positives = 219/370 (59%), Gaps = 10/370 (2%)
Query: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK 430
L EA S G V R LL+ G +N H+ E ES L LAC G+ E+ + LL A+ E +
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 431 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
++ T LM A G++++ +LLL A VN + + + LT A GG V++ +L+
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Query: 490 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV 549
GA++E+ N+ G+TPLMEAA GH E+ +LL GA IN + E +E+ALTLAC G L++
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
Query: 550 ADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACE 606
FL++AGAD E T LMEA +GH+E+ + LL +GA V+ + ++ LT A
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
Query: 607 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666
GH ++A +L++ GA+LE ++ G TPLM+AAR GH V L+++GAN+N T T
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 507
Query: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTSVVCYLLDYPNNLLS 725
L+LAC GG V + L+ GAD ++ G ST L+EA++ GH +V YLL N+ +
Sbjct: 508 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 563
Query: 726 APPPDVTQLT 735
T LT
Sbjct: 564 TTATGDTALT 573
Score = 207 bits (526), Expect = 1e-52
Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)
Query: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145
+L AC+ G V+ LL+ G S+ ++G + L LA +AG+ + ++LL A++E +
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205
+ TPL A SGG ++V+LLL A+ ++ + T L+ A +GG+V+I+K+LLN
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Query: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265
GA I ++ G +PLM AA GH ++LLD G+ IN + +ALTLAC++G
Sbjct: 328 GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385
Query: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1325
++V LL+ A+ EH+ T LMEA G+ EV R+LLD GA VN P S ++ LT
Sbjct: 386 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 443
Query: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1385
+AA GH + LLI RGA+++ N +G TPL AA GH ++V LL+ GA+++A
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
Query: 1386 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1406
TPLM A ++GH+++V+YL+
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555
Score = 198 bits (503), Expect = 7e-50
Identities = 118/314 (37%), Positives = 182/314 (57%), Gaps = 10/314 (3%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
D+++Q+ + + TALT ACAGG ++V+ LL GA+IE ++ G TPL+ AA+AGHV V
Sbjct: 297 DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355
Query: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
+LLD+GA I S K++ L+LAC G ++V LL GA++EH+ +T L A
Sbjct: 356 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
Query: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253
G+V + ++LL++GA++N S SPL LAA GH LL++ G+++ ++
Sbjct: 416 GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEGY 472
Query: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312
T L A +G E+V+LLL + AN+ + +T T L A GG++EV L+ GAD+
Sbjct: 473 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 532
Query: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372
T L A+ +GH + + L+ GA++ G+T L A GH DV +L
Sbjct: 533 L-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Query: 1373 VQAGADVDAADNRK 1386
+QAGAD+D ++ K
Sbjct: 588 LQAGADLDKQEDMK 601
Score = 173 bits (439), Expect = 2e-42
Identities = 118/324 (36%), Positives = 179/324 (55%), Gaps = 9/324 (2%)
Query: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
T L A +GG+ ++V+ LL A + + G T L A G V +V++LL+ GA+IE
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGAN-KEHRNVSDYTPLSLAASGGYVNIIKILL 1203
+E TPL A S G EV +LL GA H N + L+LA G++++++ LL
Sbjct: 334 HNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
Query: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263
AGA+ +T + LM A M+GH +LLLD G+ +N + + + LTLA G
Sbjct: 393 EAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGG 449
Query: 1264 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1323
E+ +LL++R AN+E G TPLMEAA G+ E+ +LL +GA++NA +++TA
Sbjct: 450 HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQETA 508
Query: 1324 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1383
LT+A G + + LI GA I++ +TPL A+ GHL++V+ L+ +GA+V A
Sbjct: 509 LTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATT 565
Query: 1384 NRKITPLMAAFRKGHVKVVRYLVK 1407
T L A GH V L++
Sbjct: 566 ATGDTALTYACENGHTDVADVLLQ 589
Score = 156 bits (394), Expect = 3e-37
Identities = 103/288 (35%), Positives = 150/288 (52%), Gaps = 36/288 (12%)
Query: 1154 LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1213
L+ ACS G V LL G + + L LA S GY + ++LL A + R
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR- 267
Query: 1214 GSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLD 1273
G+K I+PLM A+ G+ VKLLL +D+N+Q T NTALT AC G ++V +LL+
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATG-NTALTYACAGGFVDIVKVLLN 326
Query: 1274 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1333
AN+E + G TPLMEAAS G+ EV RVLLD GA +N +++ALT+A KGH
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKGHL 385
Query: 1334 ---------------------------------KFCELLIGRGAHIDVRNKKGNTPLWLA 1360
+ LL+ GA +++ +PL LA
Sbjct: 386 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 445
Query: 1361 ANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
A GGH+++ LL++ GA+++ ++ TPLM A R+GH ++V L+ +
Sbjct: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Score = 72.4 bits (176), Expect = 5e-12
Identities = 60/204 (29%), Positives = 87/204 (42%), Gaps = 5/204 (2%)
Query: 522 QGANINAQTEETQET--ALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLEL 579
+GA++ ETQ AL A G L AD A ++ ++ + A E L
Sbjct: 131 EGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAAL 190
Query: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
+ N H +L AC +G + LL G + +E G + L A
Sbjct: 191 TRM---KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACS 247
Query: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
AG+ Q L++ ANV D T L A +GG+L +V+LLL H AD + G+T
Sbjct: 248 AGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNT 307
Query: 700 MLIEAAKGGHTSVVCYLLDYPNNL 723
L A GG +V LL+ N+
Sbjct: 308 ALTYACAGGFVDIVKVLLNEGANI 331
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 887 bits (2293), Expect = 0.0
Identities = 468/586 (79%), Positives = 505/586 (86%), Gaps = 35/586 (5%)
Query: 78 RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122
RT R + +S +SGGGG G G GGG GGG ++ S+E+E
Sbjct: 42 RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
Query: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182
VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
Query: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
AFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 154 -----------AFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 202
Query: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302
S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 203 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 262
Query: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL GA+IED
Sbjct: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
Query: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
Query: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 442
Query: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 443 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 502
Query: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 503 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 562
Query: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648
YACENGHTDVADVLLQAGADL+ + E +T L A H V F
Sbjct: 563 YACENGHTDVADVLLQAGADLD-KQEDMKTILEGIDPAKHQVRVAF 607
Score = 246 bits (628), Expect = 2e-64
Identities = 150/370 (40%), Positives = 219/370 (59%), Gaps = 10/370 (2%)
Query: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK 430
L EA S G V R LL+ G +N H+ E ES L LAC G+ E+ + LL A+ E +
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 256
Query: 431 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
++ T LM A G++++ +LLL A VN + + + LT A GG V++ +L+
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
Query: 490 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV 549
GA++E+ N+ G+TPLMEAA GH E+ +LL GA IN + E +E+ALTLAC G L++
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
Query: 550 ADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACE 606
FL++AGAD E T LMEA +GH+E+ + LL +GA V+ + ++ LT A
Sbjct: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
Query: 607 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666
GH ++A +L++ GA+LE ++ G TPLM+AAR GH V L+++GAN+N T T
Sbjct: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
Query: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTSVVCYLLDYPNNLLS 725
L+LAC GG V + L+ GAD ++ G ST L+EA++ GH +V YLL N+ +
Sbjct: 497 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 552
Query: 726 APPPDVTQLT 735
T LT
Sbjct: 553 TTATGDTALT 562
Score = 207 bits (526), Expect = 1e-52
Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)
Query: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145
+L AC+ G V+ LL+ G S+ ++G + L LA +AG+ + ++LL A++E +
Sbjct: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
Query: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205
+ TPL A SGG ++V+LLL A+ ++ + T L+ A +GG+V+I+K+LLN
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
Query: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265
GA I ++ G +PLM AA GH ++LLD G+ IN + +ALTLAC++G
Sbjct: 317 GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374
Query: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1325
++V LL+ A+ EH+ T LMEA G+ EV R+LLD GA VN P S ++ LT
Sbjct: 375 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 432
Query: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1385
+AA GH + LLI RGA+++ N +G TPL AA GH ++V LL+ GA+++A
Sbjct: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
Query: 1386 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1406
TPLM A ++GH+++V+YL+
Sbjct: 493 TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 544
Score = 198 bits (503), Expect = 7e-50
Identities = 118/314 (37%), Positives = 182/314 (57%), Gaps = 10/314 (3%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
D+++Q+ + + TALT ACAGG ++V+ LL GA+IE ++ G TPL+ AA+AGHV V
Sbjct: 286 DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 344
Query: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
+LLD+GA I S K++ L+LAC G ++V LL GA++EH+ +T L A
Sbjct: 345 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 404
Query: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253
G+V + ++LL++GA++N S SPL LAA GH LL++ G+++ ++
Sbjct: 405 GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEGY 461
Query: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312
T L A +G E+V+LLL + AN+ + +T T L A GG++EV L+ GAD+
Sbjct: 462 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 521
Query: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372
T L A+ +GH + + L+ GA++ G+T L A GH DV +L
Sbjct: 522 L-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 576
Query: 1373 VQAGADVDAADNRK 1386
+QAGAD+D ++ K
Sbjct: 577 LQAGADLDKQEDMK 590
Score = 173 bits (439), Expect = 2e-42
Identities = 118/324 (36%), Positives = 179/324 (55%), Gaps = 9/324 (2%)
Query: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
T L A +GG+ ++V+ LL A + + G T L A G V +V++LL+ GA+IE
Sbjct: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
Query: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGAN-KEHRNVSDYTPLSLAASGGYVNIIKILL 1203
+E TPL A S G EV +LL GA H N + L+LA G++++++ LL
Sbjct: 323 HNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 381
Query: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263
AGA+ +T + LM A M+GH +LLLD G+ +N + + + LTLA G
Sbjct: 382 EAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGG 438
Query: 1264 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1323
E+ +LL++R AN+E G TPLMEAA G+ E+ +LL +GA++NA +++TA
Sbjct: 439 HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQETA 497
Query: 1324 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1383
LT+A G + + LI GA I++ +TPL A+ GHL++V+ L+ +GA+V A
Sbjct: 498 LTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATT 554
Query: 1384 NRKITPLMAAFRKGHVKVVRYLVK 1407
T L A GH V L++
Sbjct: 555 ATGDTALTYACENGHTDVADVLLQ 578
Score = 167 bits (422), Expect = 2e-40
Identities = 108/286 (37%), Positives = 146/286 (51%), Gaps = 22/286 (7%)
Query: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV 496
AL+EA EV R L S +C AAL + +
Sbjct: 148 ALLEAAAFADPEVLRRLTSS-----------------VSCALDEAAAALTRMKAENSHNA 190
Query: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556
L EA +G V LL +G ++N TEE E+ L LAC G+ E+A L+
Sbjct: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 249
Query: 557 GADIE----LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDV 612
A++E G TPLM A+ G+L++VK LL A+V++ +ATG+TALTYAC G D+
Sbjct: 250 HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDI 309
Query: 613 ADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC 672
VLL GA++E +E G TPLM+AA AGHV + L+ GA +N + + L+LAC
Sbjct: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369
Query: 673 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
GHL +V LL GAD H+ + T L+EA GH V LLD
Sbjct: 370 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415
Score = 156 bits (394), Expect = 3e-37
Identities = 103/288 (35%), Positives = 150/288 (52%), Gaps = 36/288 (12%)
Query: 1154 LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1213
L+ ACS G V LL G + + L LA S GY + ++LL A + R
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR- 256
Query: 1214 GSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLD 1273
G+K I+PLM A+ G+ VKLLL +D+N+Q T NTALT AC G ++V +LL+
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATG-NTALTYACAGGFVDIVKVLLN 315
Query: 1274 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1333
AN+E + G TPLMEAAS G+ EV RVLLD GA +N +++ALT+A KGH
Sbjct: 316 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKGHL 374
Query: 1334 ---------------------------------KFCELLIGRGAHIDVRNKKGNTPLWLA 1360
+ LL+ GA +++ +PL LA
Sbjct: 375 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 434
Query: 1361 ANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
A GGH+++ LL++ GA+++ ++ TPLM A R+GH ++V L+ +
Sbjct: 435 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
Score = 68.9 bits (167), Expect = 6e-11
Identities = 44/135 (32%), Positives = 62/135 (45%)
Query: 589 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648
N H +L AC +G + LL G + +E G + L A AG+ Q
Sbjct: 186 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
Query: 649 LISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 708
L++ ANV D T L A +GG+L +V+LLL H AD + G+T L A GG
Sbjct: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
Query: 709 HTSVVCYLLDYPNNL 723
+V LL+ N+
Sbjct: 306 FVDIVKVLLNEGANI 320
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 256 bits (653), Expect = 3e-67
Identities = 209/691 (30%), Positives = 315/691 (45%), Gaps = 97/691 (14%)
Query: 131 EVESFILD--QDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLS 188
E + F L +L+ E A ++ +GT L T+ P+ Q L+ L++A ++
Sbjct: 451 EAQEFALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA--HVN 508
Query: 189 TADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSL-AEACSEGDV 247
+ D R + V AL+ + T + ++ N S+ R+L A A G +
Sbjct: 509 SEDD----------RTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSL 558
Query: 248 NAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR----------- 296
+ V L+ G + G + L LA G+ ++ L+ AN+
Sbjct: 559 DVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSA 618
Query: 297 ---------------GIKGDI------TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGN 335
G+K D T L AAA GGH IV LL H A+VN + G
Sbjct: 619 AWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR 678
Query: 336 TALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAG-----SAGHVEVARLLLENG 390
TAL A G+ ++V+ LL+ GA + + +G T L A S GH V LL++ G
Sbjct: 679 TALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRG 738
Query: 391 AGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH---- 446
A ++ H ++ + L +A Y+GH+++V LLE GAD +H + T L+ A GH
Sbjct: 739 AEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVV 797
Query: 447 -----------------------------VEVARLLLDSGAQVNMPADSFESPLTLAACG 477
VEV R LLD G N D+ +PL +AA
Sbjct: 798 NTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFE 857
Query: 478 GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETA 537
GH + LIE+GA E++++G P + A++EGH + V +LL +NI+ + + + A
Sbjct: 858 GHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRN-A 916
Query: 538 LTLACCGGFLEVADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATT 594
L +A G ++ + L GAD+ + L A E L + +Y L GANV A+
Sbjct: 917 LRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASD 976
Query: 595 ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGA 654
A G TAL +C GH ++ VL+ AD+ R+ L AA GHV VQ LI GA
Sbjct: 977 AEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGA 1036
Query: 655 NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
V+ T N T L +A GH+ VV++LL HGADP H + G T + AAK GH+ ++
Sbjct: 1037 VVDHT-CNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIK 1095
Query: 715 YLLDYPNNLLSAPPPDVTQLTPPSHDLNRAP 745
L Y + L+ P P H + + P
Sbjct: 1096 LLEKYGASSLNGCSPS------PVHTMEQKP 1120
Score = 190 bits (483), Expect = 1e-47
Identities = 118/334 (35%), Positives = 189/334 (56%), Gaps = 7/334 (2%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
D+D +T + AL + + GH +V L++RGA ++H DK G TPL++AA GHV VV+
Sbjct: 707 DVDGRTALSV-AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVD 765
Query: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
+LL+ GAD++ ++ TPL A S G VV LL GA + + T LS+A++
Sbjct: 766 LLLEGGADVD-HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQ 824
Query: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253
G V +++ LL+ G + N R + G +PL +AA GH + L++ G+ N +I+ +
Sbjct: 825 GNVEVVRTLLDRGLDENHRDDA--GWTPLHMAAFEGHRLICEALIEQGARTN-EIDNDGR 881
Query: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1313
LA +G + V +LL+ K+N++ R G L AA G+ ++ +L GADVN
Sbjct: 882 IPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 941
Query: 1314 PPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373
R T L I A + E + GA+++ + +G T L ++ GH+++VQ+L+
Sbjct: 942 KDA-DGRPT-LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLI 999
Query: 1374 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
ADV+AADN K + L +A +GHVKVV+ L++
Sbjct: 1000 AYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE 1033
Score = 184 bits (466), Expect = 1e-45
Identities = 122/355 (34%), Positives = 190/355 (53%), Gaps = 13/355 (3%)
Query: 1069 IYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH 1128
+Y + +D +++ TAL A GGHE++V LL+ GA + D +G T LI AA GH
Sbjct: 631 LYAGVKVDC-ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGH 689
Query: 1129 VGVVEILLDNGADIEAQSERTKDTPLSLA-----CSGGRQEVVELLLARGANKEHRNVSD 1183
+VE LLD+GA++ + + T LS+A S G VV LL+ RGA +H +
Sbjct: 690 REIVEHLLDHGAEVNHEDVDGR-TALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDG 748
Query: 1184 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSD 1243
TPL +AA G+V+++ +LL GA+++ + G +PL+ AA GH + V LL G+
Sbjct: 749 MTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN--GRTPLLAAASMGHASVVNTLLFWGAA 806
Query: 1244 INAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1303
+++ I++ T L++A QG EVV LLDR + HR G TPL AA G+ +
Sbjct: 807 VDS-IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEA 865
Query: 1304 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANG 1363
L+++GA N + + +A+ +GHY ++L+ ++ID R G L +AA
Sbjct: 866 LIEQGARTN--EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALE 923
Query: 1364 GHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE-VNQFPSDSE 1417
GH D+V+LL GADV+ D L + + + Y ++ N SD+E
Sbjct: 924 GHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAE 978
Score = 176 bits (445), Expect = 4e-43
Identities = 119/314 (37%), Positives = 163/314 (51%), Gaps = 9/314 (2%)
Query: 1096 EELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLS 1155
+E++Q L++ GA + D + T I+ + LLDNGA + Q + T L+
Sbjct: 494 QEVLQLLVKAGAHVNSEDDR--TSCIVRQALEREDSIRTLLDNGASVN-QCDSNGRTLLA 550
Query: 1156 LACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGS 1215
A G +VV LL++RGA+ E + +TPL+LAA G+ ++ L+ GA IN
Sbjct: 551 NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
Query: 1216 KLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRK 1275
G + L AA GHT V LL G ++ + + TAL A + G ++V LL
Sbjct: 611 --GWTALRSAAWGGHTEVVSALLYAGVKVDCA-DADSRTALRAAAWGGHEDIVLNLLQHG 667
Query: 1276 ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD---TALTIAADKGH 1332
A V G T L+ AA G+ E+ LLD GA+VN V AL + A KGH
Sbjct: 668 AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727
Query: 1333 YKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMA 1392
LLI RGA +D +K G TPL +AA GH+DVV LL++ GADVD DN TPL+A
Sbjct: 728 ASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787
Query: 1393 AFRKGHVKVVRYLV 1406
A GH VV L+
Sbjct: 788 AASMGHASVVNTLL 801
Score = 176 bits (445), Expect = 4e-43
Identities = 125/356 (35%), Positives = 184/356 (51%), Gaps = 39/356 (10%)
Query: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
T L +A GH ++V LLE GA ++H D G TPL+ AA+ GH VV LL GA +++
Sbjct: 750 TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809
Query: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204
+ T LS+A + G EVV LL RG ++ HR+ + +TPL +AA G+ I + L+
Sbjct: 810 IDSEGR-TVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIE 868
Query: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264
GA N G P +LA+ GH V++LL+ S+I+ + RN AL +A +G
Sbjct: 869 QGARTNEIDND--GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRN-ALRVAALEGH 925
Query: 1265 TEVVSLL---------------------------------LDRKANVEHRAKTGLTPLME 1291
++V LL L+ ANVE G T L
Sbjct: 926 RDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHV 985
Query: 1292 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNK 1351
+ G+ E+ +VL+ ADVNA + + +AL AA +GH K +LLI GA +D
Sbjct: 986 SCWQGHMEMVQVLIAYHADVNA--ADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCN 1043
Query: 1352 KGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
+G T L +AA GH+DVVQ+L++ GAD + AD T + A + GH ++++ L K
Sbjct: 1044 QGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEK 1099
Score = 175 bits (444), Expect = 5e-43
Identities = 123/336 (36%), Positives = 180/336 (53%), Gaps = 11/336 (3%)
Query: 1078 QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 1137
Q +SN T L A G ++V L+ RGA +E D G TPL LAA GH VV L+
Sbjct: 540 QCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIG 599
Query: 1138 NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVN 1197
GA+I +++ T L A GG EVV LL G + + T L AA GG+ +
Sbjct: 600 CGANIN-HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHED 658
Query: 1198 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALT 1257
I+ LL GAE+N G + L+ AA GH V+ LLD G+++N + + + TAL+
Sbjct: 659 IVLNLLQHGAEVNKADNE--GRTALIAAAYMGHREIVEHLLDHGAEVNHE-DVDGRTALS 715
Query: 1258 LACF-----QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312
+A +G VVSLL+DR A V+H K G+TPL+ AA G+ +V +LL+ GADV+
Sbjct: 716 VAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD 775
Query: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372
++ T L AA GH L+ GA +D + +G T L +A+ G+++VV+ L
Sbjct: 776 --HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
Query: 1373 VQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
+ G D + D+ TPL A +GH + L+++
Sbjct: 834 LDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869
Score = 159 bits (401), Expect = 4e-38
Identities = 118/380 (31%), Positives = 182/380 (47%), Gaps = 9/380 (2%)
Query: 225 ESTANAGQSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYE 281
E A+ +DN L A S G + V LL G +V+ EG ++L +A + G E
Sbjct: 769 EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVE 828
Query: 282 LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
+ + LL + R G TPL AA GH I + L+ A N + G A
Sbjct: 829 VVRTLLDRGLDENHRDDAG-WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILA 887
Query: 342 CAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401
G+ D V++LLE+ ++I+ +G L A GH ++ LL +GA +N + +
Sbjct: 888 SQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGR 947
Query: 402 ESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 461
+ LA + L M + LE GA+ E E TAL +C GH+E+ ++L+ A VN
Sbjct: 948 PTLYILAL-ENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVN 1006
Query: 462 MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG 521
+ S L AA GHV++ LLIE GA ++ ++G T L AA+EGH ++V +LL
Sbjct: 1007 AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLE 1066
Query: 522 QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVK 581
GA+ N ++ TA+ +A G ++ L K GA GCS + ++ L+ +
Sbjct: 1067 HGADPN-HADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLS 1125
Query: 582 ---YLLAAGANVHATTATGD 598
L +N +T GD
Sbjct: 1126 SKVQSLTIKSNSSGSTGGGD 1145
Score = 141 bits (356), Expect = 7e-33
Identities = 94/298 (31%), Positives = 159/298 (53%), Gaps = 6/298 (2%)
Query: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139
+S T L++A A G+ E+V+TLL+RG HRD G+TPL +AA GH + E L++ G
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
Query: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199
A + + P LA G + V++LL +N + R L +AA G+ +I+
Sbjct: 871 ARTN-EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 929
Query: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1259
++L + GA++N + G L + A+ + L+ G+++ A R TAL ++
Sbjct: 930 ELLFSHGADVNCKDAD--GRPTLYILALENQLTMAEYFLENGANVEASDAEGR-TALHVS 986
Query: 1260 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1319
C+QG E+V +L+ A+V + L AA G+ +V ++L++ GA V+ +
Sbjct: 987 CWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH--TCNQ 1044
Query: 1320 RDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1377
TAL IAA +GH ++L+ GA + ++ G T + +AA GH +++LL + GA
Sbjct: 1045 GATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
Score = 86.7 bits (213), Expect = 3e-16
Identities = 65/181 (35%), Positives = 95/181 (52%), Gaps = 8/181 (4%)
Query: 1234 VKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAA 1293
++LL+ G+ +N+ E +R + + + R + + LLD A+V G T L AA
Sbjct: 497 LQLLVKAGAHVNS--EDDRTSCIVRQALE-REDSIRTLLDNGASVNQCDSNGRTLLANAA 553
Query: 1294 SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKG 1353
G +V +L+ +GAD+ T LT+AA +GH K LIG GA+I+ ++ G
Sbjct: 554 YSGSLDVVNLLVSRGADLEIEDAHGH--TPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
Query: 1354 NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK---EVN 1410
T L AA GGH +VV L+ AG VD AD T L AA GH +V L++ EVN
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
Query: 1411 Q 1411
+
Sbjct: 672 K 672
Score = 40.4 bits (93), Expect = 0.023
Identities = 51/196 (26%), Positives = 81/196 (41%), Gaps = 13/196 (6%)
Query: 1931 PLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSS-ASTVPGTSTNGSP 1989
P P A +SP Q SS S + S SS TT+S++ A TVP S +
Sbjct: 1154 PNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHNLS 1213
Query: 1990 SSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPP 2049
+ +++ + S + + V+ +++ T ++ P+++ + PS S
Sbjct: 1214 FTEQIQQHS----LPRSRSRQSIVSPSST---TQSLGQSHNSPSSEFEWSQVKPSLKSTK 1266
Query: 2050 AQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQ 2109
A GG S NS GSA S+S Q P V+E T+ + S +A +Q
Sbjct: 1267 ASKGGKSENS-AKSGSAGKKAKQSNSSQ----PKVLEYEMTQFDRRGPIAKSGTAAPPKQ 1321
Query: 2110 QPPGSVSQEPRPPLQQ 2125
P S + P QQ
Sbjct: 1322 MPAESQCKIMIPSAQQ 1337
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 249 bits (637), Expect = 2e-65
Identities = 166/475 (34%), Positives = 267/475 (56%), Gaps = 8/475 (1%)
Query: 243 SEGD-VNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
++GD V V+ LL V++ T + + L +A G+Y + ++LL AN R + G
Sbjct: 319 AQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG- 377
Query: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
TPL A +K+++LL+ + A + A + +G T + A G++++V +LL++GAS +
Sbjct: 378 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 437
Query: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
N G T L A AG VEV R LL NGA ++ + E +++ L +A G E+V+ LL
Sbjct: 438 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLL 496
Query: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481
+ A + T +T L + +G V+VA +LL++GA ++ +PL +AA G ++
Sbjct: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 556
Query: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
+A LL++R A+ + G TPL AA ++++ LLL +GA+ +A T + T L +A
Sbjct: 557 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIA 615
Query: 542 CCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
+++A L+ GA+ + TPL A+QEGH ++V LL GAN+H +T +G
Sbjct: 616 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 675
Query: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
T+L A + +VAD+L + GAD + ++ G TPL+ A G+V V FL+ +GANVN
Sbjct: 676 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 735
Query: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
T N +T L A GH ++ +LL HGA P +G+T L A + G+ SVV
Sbjct: 736 KT-KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789
Score = 221 bits (564), Expect = 6e-57
Identities = 178/545 (32%), Positives = 271/545 (49%), Gaps = 29/545 (5%)
Query: 219 LTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAG 278
+T M +S +NA S A G+++ V + L G +N + G + L LA G
Sbjct: 1 MTTMLQKSDSNA------SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEG 54
Query: 279 YYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTAL 338
+ L Q LL ++V+ KG+ T L A+ G ++VK+L+ A++NAQS G T L
Sbjct: 55 HVGLVQELLGRGSSVDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113
Query: 339 TYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN 398
A ++DVVK LLE+GA+ E+G TPL A GH + +LLEN
Sbjct: 114 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT-----KG 168
Query: 399 EFKESALTLACYKGHLEMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVA 450
+ + AL +A K + LL + AD + K T+ T L A G+V VA
Sbjct: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228
Query: 451 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAARE 510
LLL+ GA V+ A + +PL +A+ G+ + LL++RG ++ +G TPL AAR
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288
Query: 511 GHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA---DIELGCSTP 567
GH+++V LLL +GA + A+T+ + L +A G +E L++ A D+ L T
Sbjct: 289 GHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347
Query: 568 LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 627
L AA GH + K LL AN +A G T L AC+ V ++L++ GA ++ +
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407
Query: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687
E G TP+ AA GH+ V L+ GA+ + T + T L +A G + VV LL +G
Sbjct: 408 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAARAGQVEVVRCLLRNG 466
Query: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRV 747
A R ++ T L A++ G T +V LL + ++ P T P H R +V
Sbjct: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQH----MAHPDAATTNGYTPLHISAREGQV 522
Query: 748 PVQAL 752
V ++
Sbjct: 523 DVASV 527
Score = 217 bits (553), Expect = 1e-55
Identities = 169/489 (34%), Positives = 246/489 (50%), Gaps = 13/489 (2%)
Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
A G+ N V+ LL G ++ T +G + L A +G+ ++ ++LL A + R K
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKN 310
Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
++PL AA G HV+ VK LL HKA V+ + TAL A G+ V K+LL+ A+
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370
Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT---LACYKGHLEMV 417
NG TPL A ++V LL++ GA I ES LT +A + GHL +V
Sbjct: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 426
Query: 418 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 477
LL+ GA + TAL A G VEV R LL +GA V+ A ++PL +A+
Sbjct: 427 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 486
Query: 478 GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETA 537
G E+ LL++ A + GYTPL +AREG ++ ++LL GA + T++ T
Sbjct: 487 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF-TP 545
Query: 538 LTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATT 594
L +A G L+VA L++ A + TPL AA + ++ LL GA+ HAT
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
Query: 595 ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGA 654
G T L A + +A LL GA+ ++ G TPL A++ GH V L+ KGA
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
Query: 655 NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
N++ +T + T L LA + V ++L HGAD K G T LI A G+ +V
Sbjct: 666 NIHMSTKSG-LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 724
Query: 715 YLLDYPNNL 723
+LL N+
Sbjct: 725 FLLKQGANV 733
Score = 215 bits (547), Expect = 5e-55
Identities = 168/518 (32%), Positives = 259/518 (50%), Gaps = 12/518 (2%)
Query: 221 RMRAESTANAGQSDNRSLAEACSEGDVNA-VRKLLIEGRSVNEHTEEGESLLCLACSAGY 279
++R + A + D+ A + D NA V+ ++ VN TE G + L +A G
Sbjct: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM----VNRTTESGFTPLHIAAHYGN 224
Query: 280 YELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALT 339
+A +LL A V+ G ITPL A+ G+ +VKLLL ++A++ G T L
Sbjct: 225 VNVATLLLNRGAAVDFTARNG-ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH 283
Query: 340 YACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE 399
A G+ VV++LLE GA + +NG +PL A HVE + LL++ A ++ + +
Sbjct: 284 CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD 343
Query: 400 FKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ 459
+ +AL +A + GH + + LL+ A+ + T L AC ++V LL+ GA
Sbjct: 344 YL-TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 402
Query: 460 VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALL 519
+ +S +P+ +AA GH+ + LL++ GAS + N G T L AAR G E+V L
Sbjct: 403 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
Query: 520 LGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGH 576
L GA ++A+ E Q T L +A G E+ L++ A + + TPL +A+EG
Sbjct: 463 LRNGALVDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 521
Query: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
+++ LL AGA T G T L A + G DVA +LLQ A + + G TPL
Sbjct: 522 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 581
Query: 637 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD 696
AA + L+ KGA+ + TA N +T L +A + + LL +GA+ K
Sbjct: 582 AAHYDNQKVALLLLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 640
Query: 697 GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQL 734
G T L A++ GHT +V LLD N+ + +T L
Sbjct: 641 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 678
Score = 199 bits (506), Expect = 3e-50
Identities = 160/483 (33%), Positives = 241/483 (49%), Gaps = 16/483 (3%)
Query: 193 KAFADPEVLRRLTS---SVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA 249
KA D L LT+ + C L RA A A + L AC + +
Sbjct: 334 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 392
Query: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309
+ L+ G S+ TE G + + +A G+ + +LL A+ + I+G+ T L AA
Sbjct: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAA 451
Query: 310 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT 369
G V++V+ LL + A V+A++ T L A G ++V++LL+ A + NG+T
Sbjct: 452 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 511
Query: 370 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKE--SALTLACYKGHLEMVRFLLEAGADQ 427
PL + G V+VA +LLE GA HS K+ + L +A G L++ + LL+ A
Sbjct: 512 PLHISAREGQVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 568
Query: 428 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 487
+ T L A + +VA LLL+ GA + A + +PL +AA +++A+ L+
Sbjct: 569 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 628
Query: 488 ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
GA V +G TPL A++EGH +MV LLL +GANI+ T+ T+L LA +
Sbjct: 629 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKV 687
Query: 548 EVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604
VAD L K GAD + TPL+ A G++++V +LL GANV+A T G T L A
Sbjct: 688 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 747
Query: 605 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL--ISKGANVNRTTAN 662
+ GHT + +VLLQ GA + G T L A R G++ V L +++ TT
Sbjct: 748 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT 807
Query: 663 NDH 665
H
Sbjct: 808 EKH 810
Score = 191 bits (486), Expect = 6e-48
Identities = 217/844 (25%), Positives = 354/844 (41%), Gaps = 100/844 (11%)
Query: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGA 425
+ + + A AG+++ L+ G INT N+ +AL LA +GH+ +V+ LL G+
Sbjct: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 67
Query: 426 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 485
+ T + +TAL A + G EV ++L+ GA +N + + +PL +AA H+++
Sbjct: 68 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 127
Query: 486 LIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ---------GANINAQTEETQET 536
L+E GA+ ++G+TPL A ++GH + VA+LL +I A+ ++T+
Sbjct: 128 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 187
Query: 537 ALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTAT 596
AL L + ++ + TPL AA G++ + LL GA V T
Sbjct: 188 ALLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVNVATLLLNRGAAVDFTARN 244
Query: 597 GDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANV 656
G T L A + G+T++ +LL G ++ ++ G TPL AAR+GH V+ L+ +GA +
Sbjct: 245 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 304
Query: 657 NRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716
T N + L +A G H+ V+ LL H A D T L AA GH V L
Sbjct: 305 LART-KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 363
Query: 717 LDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQAL-----PMVVPPQEPDKPPANVA-- 769
LD N P P H + R+ V L + E P +VA
Sbjct: 364 LDKRAN----PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 419
Query: 770 ------TTLPIRNKAAS-----KQKSSSHLPANSQDVQGYITNQSPESIVE-EAQGKLTE 817
L ++N A+ + +++ H+ A + V+ ++V+ A+ + T
Sbjct: 420 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 479
Query: 818 LEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELN-KTREEQIQKKQKILEELQKVEREL 876
L + + QL +AH D T L+ RE Q+ +LE L
Sbjct: 480 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE--AGAAHSL 537
Query: 877 QLK---TQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVD 933
K T + +Y + ++ LQ++ LTP+ V A L
Sbjct: 538 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL---- 593
Query: 934 PVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGPLPPGSIANLTELQGV----IVGQPV 989
+L K A+ G+ P+ A + +A+ L G+ N+ QGV + Q
Sbjct: 594 -LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE- 651
Query: 990 LGQAQLAGL----GQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSI 1045
G + L G I T+ GL +AA + + H
Sbjct: 652 -GHTDMVTLLLDKGANIHMSTKSGLTSLH------------LAAQEDKVNVADILTKH-- 696
Query: 1046 AASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLER 1105
D DA T+ + T L +AC G+ ++V LL++
Sbjct: 697 --------------------------GADQDAHTKLGY-TPLIVACHYGNVKMVNFLLKQ 729
Query: 1106 GASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEV 1165
GA++ + K G+TPL AA GH ++ +LL +GA A + +T L++A G V
Sbjct: 730 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA-TTANGNTALAIAKRLGYISV 788
Query: 1166 VELL 1169
V+ L
Sbjct: 789 VDTL 792
Score = 177 bits (450), Expect = 9e-44
Identities = 165/575 (28%), Positives = 267/575 (46%), Gaps = 29/575 (5%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
I A TES T + +A GH +V LL+ GAS + + +G T L +AA AG V VV
Sbjct: 403 IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461
Query: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
LL NGA ++A++ R + TPL +A G+ E+V+LLL A+ + + YTPL ++A G
Sbjct: 462 LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
V++ +LL AGA + T K G +PL +AA G KLLL + ++ + N T
Sbjct: 521 QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 577
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
L +A +V LLL++ A+ AK G TPL AA ++ LL+ GA+ N
Sbjct: 578 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 636
Query: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
V T L +A+ +GH LL+ +GA+I + K G T L LAA ++V +L +
Sbjct: 637 -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 695
Query: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1434
GAD DA TPL+ A G+VK+V +L+K+ +++ +
Sbjct: 696 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV--NAKTKNGYTPLHQAAQQGHT 753
Query: 1435 HLCMESIVQAKDRQAAEANKNASILLEE-------LDLEKLREESRRLALAAKREKRKEK 1487
H+ + A AN N ++ + + +D K+ E EK
Sbjct: 754 HIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKH--- 810
Query: 1488 RRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISAT 1547
K E ++ ++E + E L+ ED E L + ++ G++
Sbjct: 811 ---KLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKE-LGDDSLPSSQFLDGMNYL 866
Query: 1548 WTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSS 1607
+L G R++++ + SS R + + + + DD + I Q + E++ +S
Sbjct: 867 RYSLEGG---RSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNS 923
Query: 1608 TSESGDS---DNMRISSCSDESSNSNSSRKSDNHS 1639
S + DN+ +SS S ++ + DN S
Sbjct: 924 YRLSWGTENLDNVALSSSPIHSGRASPCLERDNSS 958
Score = 172 bits (436), Expect = 4e-42
Identities = 138/405 (34%), Positives = 195/405 (48%), Gaps = 81/405 (20%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
+D+ T+ + TAL +A G E+V+ L++ GA+I + + GFTPL +AA H+ VV+
Sbjct: 69 VDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 127
Query: 1135 LLDNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGANKEHR------------- 1179
LL+NGA+ QS T+D TPL++A G + V +LL + R
Sbjct: 128 LLENGAN---QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT 184
Query: 1180 ------------------------NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGS 1215
S +TPL +AA G VN+ +LLN GA ++ +
Sbjct: 185 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT--A 242
Query: 1216 KLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRK 1275
+ GI+PL +A+ G+T VKLLLD G I+A+ T L A G +VV LLL+R
Sbjct: 243 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-TPLHCAARSGHDQVVELLLERG 301
Query: 1276 ANVEHRAKTGLTPLMEAASGGYAE---------------------------------VGR 1302
A + R K GL+PL AA G + E V +
Sbjct: 302 APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK 361
Query: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362
+LLDK A+ NA + T L IA K K ELL+ GA I + G TP+ +AA
Sbjct: 362 LLLDKRANPNARALNGF--TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 419
Query: 1363 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
GHL++V LL+Q GA D + R T L A R G V+VVR L++
Sbjct: 420 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 464
Score = 171 bits (433), Expect = 9e-42
Identities = 122/334 (36%), Positives = 185/334 (55%), Gaps = 9/334 (2%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
++ TES T L +A G+ + LL RGA+++ + G TPL +A+ G+ +V++
Sbjct: 205 VNRTTESGF-TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 263
Query: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
LLD G I+A++ R TPL A G +VVELLL RGA R + +PL +AA G
Sbjct: 264 LLDRGGQIDAKT-RDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 322
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
+V +K LL A ++ T L + L +AA GH KLLLD ++ NA+ N T
Sbjct: 323 HVECVKHLLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDKRANPNAR-ALNGFT 379
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
L +AC + R +V+ LL+ A+++ ++GLTP+ AA G+ + +LL GA +P
Sbjct: 380 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA---SP 436
Query: 1315 PVPSSR-DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373
V + R +TAL +AA G + L+ GA +D R ++ TPL +A+ G ++VQLL+
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496
Query: 1374 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Q A DAA TPL + R+G V V L++
Sbjct: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530
Score = 163 bits (412), Expect = 2e-39
Identities = 112/354 (31%), Positives = 193/354 (54%), Gaps = 20/354 (5%)
Query: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139
+S+ + + A G+ + V L+ G I ++ G L LAA GHVG+V+ LL G
Sbjct: 7 KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66
Query: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199
+ +++ +++ +T L +A G+ EVV++L+ GAN ++ + +TPL +AA +++++
Sbjct: 67 SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
Query: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1259
K LL GA N T ++ G +PL +A GH AV +LL+ +D ++ R AL +A
Sbjct: 126 KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 178
Query: 1260 CFQGRTEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1311
+ T+ +LLL N + ++K +G TPL AA G V +LL++GA V
Sbjct: 179 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238
Query: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
+ + T L +A+ +G+ +LL+ RG ID + + G TPL AA GH VV+L
Sbjct: 239 DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
Query: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATI 1425
L++ GA + A ++PL A + HV+ V++L++ ++ P D + Y+ +
Sbjct: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 348
Score = 153 bits (387), Expect = 2e-36
Identities = 115/331 (34%), Positives = 169/331 (51%), Gaps = 10/331 (3%)
Query: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
T N T L +A G+ +V+ LL+RG I+ + + G TPL AA +GH VVE+LL+
Sbjct: 241 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 300
Query: 1139 GADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 1196
GA + A RTK+ +PL +A G E V+ LL A + + T L +AA G+
Sbjct: 301 GAPLLA---RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 357
Query: 1197 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1256
+ K+LL+ A N+R + G +PL +A ++LL+ G+ I A E+ T +
Sbjct: 358 RVTKLLLDKRANPNARALN--GFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPI 414
Query: 1257 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316
+A F G +V LLL A+ + G T L AA G EV R LL GA V+A
Sbjct: 415 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR-- 472
Query: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376
T L IA+ G + +LL+ AH D G TPL ++A G +DV +L++AG
Sbjct: 473 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 532
Query: 1377 ADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
A A + TPL A + G + V + L++
Sbjct: 533 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 563
Score = 76.6 bits (187), Expect = 3e-13
Identities = 53/180 (29%), Positives = 92/180 (51%), Gaps = 10/180 (5%)
Query: 1290 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1349
+ AA G + L G D+N + AL +AA +GH + L+GRG+ +D
Sbjct: 15 LRAARAGNLDKVVEYLKGGIDINT--CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72
Query: 1350 NKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE- 1408
KKGNT L +A+ G +VV++LV+ GA+++A TPL A ++ H+ VV+YL++
Sbjct: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
Query: 1409 VNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAA-------EANKNASILLE 1461
NQ + + +A + + + +E+ + K R A + K+A++LL+
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
Score = 32.0 bits (71), Expect = 8.2
Identities = 16/59 (27%), Positives = 30/59 (50%)
Query: 1348 VRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
++ N AA G+LD V ++ G D++ + + L A ++GHV +V+ L+
Sbjct: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL 63
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 249 bits (637), Expect = 2e-65
Identities = 166/475 (34%), Positives = 267/475 (56%), Gaps = 8/475 (1%)
Query: 243 SEGD-VNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
++GD V V+ LL V++ T + + L +A G+Y + ++LL AN R + G
Sbjct: 340 AQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG- 398
Query: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
TPL A +K+++LL+ + A + A + +G T + A G++++V +LL++GAS +
Sbjct: 399 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
N G T L A AG VEV R LL NGA ++ + E +++ L +A G E+V+ LL
Sbjct: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLL 517
Query: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481
+ A + T +T L + +G V+VA +LL++GA ++ +PL +AA G ++
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 577
Query: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
+A LL++R A+ + G TPL AA ++++ LLL +GA+ +A T + T L +A
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIA 636
Query: 542 CCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
+++A L+ GA+ + TPL A+QEGH ++V LL GAN+H +T +G
Sbjct: 637 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 696
Query: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
T+L A + +VAD+L + GAD + ++ G TPL+ A G+V V FL+ +GANVN
Sbjct: 697 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756
Query: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
T N +T L A GH ++ +LL HGA P +G+T L A + G+ SVV
Sbjct: 757 KT-KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Score = 221 bits (563), Expect = 7e-57
Identities = 174/529 (32%), Positives = 264/529 (49%), Gaps = 23/529 (4%)
Query: 235 NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 294
N S A G+++ V + L G +N + G + L LA G+ L Q LL ++V+
Sbjct: 32 NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91
Query: 295 DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354
KG+ T L A+ G ++VK+L+ A++NAQS G T L A ++DVVK LL
Sbjct: 92 SATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150
Query: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414
E+GA+ E+G TPL A GH + +LLEN + + AL +A K
Sbjct: 151 ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT-----KGKVRLPALHIAARKDDT 205
Query: 415 EMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466
+ LL + AD + K T+ T L A G+V VA LLL+ GA V+ A +
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
Query: 467 FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526
+PL +A+ G+ + LL++RG ++ +G TPL AAR GH+++V LLL +GA +
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Query: 527 NAQTEETQETALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYL 583
A+T+ + L +A G +E L++ A D+ L T L AA GH + K L
Sbjct: 326 LARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Query: 584 LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHV 643
L AN +A G T L AC+ V ++L++ GA ++ +E G TP+ AA GH+
Sbjct: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444
Query: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703
V L+ GA+ + T + T L +A G + VV LL +GA R ++ T L
Sbjct: 445 NIVLLLLQNGASPDVTNIRGE-TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503
Query: 704 AAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQAL 752
A++ G T +V LL + ++ P T P H R +V V ++
Sbjct: 504 ASRLGKTEIVQLLLQH----MAHPDAATTNGYTPLHISAREGQVDVASV 548
Score = 217 bits (553), Expect = 1e-55
Identities = 169/489 (34%), Positives = 246/489 (50%), Gaps = 13/489 (2%)
Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
A G+ N V+ LL G ++ T +G + L A +G+ ++ ++LL A + R K
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKN 331
Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
++PL AA G HV+ VK LL HKA V+ + TAL A G+ V K+LL+ A+
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT---LACYKGHLEMV 417
NG TPL A ++V LL++ GA I ES LT +A + GHL +V
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 447
Query: 418 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 477
LL+ GA + TAL A G VEV R LL +GA V+ A ++PL +A+
Sbjct: 448 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507
Query: 478 GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETA 537
G E+ LL++ A + GYTPL +AREG ++ ++LL GA + T++ T
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF-TP 566
Query: 538 LTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATT 594
L +A G L+VA L++ A + TPL AA + ++ LL GA+ HAT
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 595 ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGA 654
G T L A + +A LL GA+ ++ G TPL A++ GH V L+ KGA
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
Query: 655 NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
N++ +T + T L LA + V ++L HGAD K G T LI A G+ +V
Sbjct: 687 NIHMSTKSG-LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 745
Query: 715 YLLDYPNNL 723
+LL N+
Sbjct: 746 FLLKQGANV 754
Score = 215 bits (547), Expect = 5e-55
Identities = 168/518 (32%), Positives = 259/518 (50%), Gaps = 12/518 (2%)
Query: 221 RMRAESTANAGQSDNRSLAEACSEGDVNA-VRKLLIEGRSVNEHTEEGESLLCLACSAGY 279
++R + A + D+ A + D NA V+ ++ VN TE G + L +A G
Sbjct: 190 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM----VNRTTESGFTPLHIAAHYGN 245
Query: 280 YELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALT 339
+A +LL A V+ G ITPL A+ G+ +VKLLL ++A++ G T L
Sbjct: 246 VNVATLLLNRGAAVDFTARNG-ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH 304
Query: 340 YACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE 399
A G+ VV++LLE GA + +NG +PL A HVE + LL++ A ++ + +
Sbjct: 305 CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD 364
Query: 400 FKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ 459
+ +AL +A + GH + + LL+ A+ + T L AC ++V LL+ GA
Sbjct: 365 YL-TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423
Query: 460 VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALL 519
+ +S +P+ +AA GH+ + LL++ GAS + N G T L AAR G E+V L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 520 LGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGH 576
L GA ++A+ E Q T L +A G E+ L++ A + + TPL +A+EG
Sbjct: 484 LRNGALVDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 542
Query: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
+++ LL AGA T G T L A + G DVA +LLQ A + + G TPL
Sbjct: 543 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602
Query: 637 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD 696
AA + L+ KGA+ + TA N +T L +A + + LL +GA+ K
Sbjct: 603 AAHYDNQKVALLLLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 661
Query: 697 GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQL 734
G T L A++ GHT +V LLD N+ + +T L
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699
Score = 209 bits (531), Expect = 4e-53
Identities = 192/598 (32%), Positives = 274/598 (45%), Gaps = 51/598 (8%)
Query: 232 QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 291
Q+ +L A EG V V++LL G SV+ T++G + L +A AG E+ +VL+ A
Sbjct: 62 QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA 121
Query: 292 NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351
N+ + G TPL AA H+ +VK LL + A+ + + G T L A G+ V
Sbjct: 122 NINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 352 VLLESGAS------------------------IEDHN-------------ENGHTPLMEA 374
+LLE+ DHN E+G TPL A
Sbjct: 181 ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240
Query: 375 GSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDE 433
G+V VA LLL GA ++ T N + L +A +G+ MV+ LL+ G + KT +
Sbjct: 241 AHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298
Query: 434 MHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASL 493
T L A GH +V LLL+ GA + + SPL +AA G HVE L++ A +
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 358
Query: 494 EEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFL 553
++V + T L AA GH + LLL + AN NA+ T L +AC ++V + L
Sbjct: 359 DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKVMELL 417
Query: 554 IKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHT 610
+K GA I+ TP+ AA GHL +V LL GA+ T G+TAL A G
Sbjct: 418 VKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQV 477
Query: 611 DVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSL 670
+V LL+ GA ++ + +TPL A+R G VQ L+ A+ + T N +T L +
Sbjct: 478 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG-YTPLHI 536
Query: 671 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPD 730
+ G + V +LL GA + K G T L AAK G V LL SA
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596
Query: 731 VTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHL 788
+T L +H N+ AL ++ P N T L I K Q +S+ L
Sbjct: 597 LTPLHVAAHYDNQK-----VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Score = 199 bits (506), Expect = 3e-50
Identities = 160/483 (33%), Positives = 241/483 (49%), Gaps = 16/483 (3%)
Query: 193 KAFADPEVLRRLTS---SVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA 249
KA D L LT+ + C L RA A A + L AC + +
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413
Query: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309
+ L+ G S+ TE G + + +A G+ + +LL A+ + I+G+ T L AA
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAA 472
Query: 310 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT 369
G V++V+ LL + A V+A++ T L A G ++V++LL+ A + NG+T
Sbjct: 473 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 532
Query: 370 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKE--SALTLACYKGHLEMVRFLLEAGADQ 427
PL + G V+VA +LLE GA HS K+ + L +A G L++ + LL+ A
Sbjct: 533 PLHISAREGQVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Query: 428 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 487
+ T L A + +VA LLL+ GA + A + +PL +AA +++A+ L+
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Query: 488 ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
GA V +G TPL A++EGH +MV LLL +GANI+ T+ T+L LA +
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKV 708
Query: 548 EVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604
VAD L K GAD + TPL+ A G++++V +LL GANV+A T G T L A
Sbjct: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
Query: 605 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL--ISKGANVNRTTAN 662
+ GHT + +VLLQ GA + G T L A R G++ V L +++ TT
Sbjct: 769 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT 828
Query: 663 NDH 665
H
Sbjct: 829 EKH 831
Score = 191 bits (486), Expect = 6e-48
Identities = 217/844 (25%), Positives = 354/844 (41%), Gaps = 100/844 (11%)
Query: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGA 425
+ + + A AG+++ L+ G INT N+ +AL LA +GH+ +V+ LL G+
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 426 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 485
+ T + +TAL A + G EV ++L+ GA +N + + +PL +AA H+++
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
Query: 486 LIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ---------GANINAQTEETQET 536
L+E GA+ ++G+TPL A ++GH + VA+LL +I A+ ++T+
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
Query: 537 ALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTAT 596
AL L + ++ + TPL AA G++ + LL GA V T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
Query: 597 GDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANV 656
G T L A + G+T++ +LL G ++ ++ G TPL AAR+GH V+ L+ +GA +
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Query: 657 NRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716
T N + L +A G H+ V+ LL H A D T L AA GH V L
Sbjct: 326 LART-KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Query: 717 LDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQAL-----PMVVPPQEPDKPPANVA-- 769
LD N P P H + R+ V L + E P +VA
Sbjct: 385 LDKRAN----PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 440
Query: 770 ------TTLPIRNKAAS-----KQKSSSHLPANSQDVQGYITNQSPESIVE-EAQGKLTE 817
L ++N A+ + +++ H+ A + V+ ++V+ A+ + T
Sbjct: 441 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 500
Query: 818 LEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELN-KTREEQIQKKQKILEELQKVEREL 876
L + + QL +AH D T L+ RE Q+ +LE L
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE--AGAAHSL 558
Query: 877 QLK---TQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVD 933
K T + +Y + ++ LQ++ LTP+ V A L
Sbjct: 559 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL---- 614
Query: 934 PVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGPLPPGSIANLTELQGV----IVGQPV 989
+L K A+ G+ P+ A + +A+ L G+ N+ QGV + Q
Sbjct: 615 -LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE- 672
Query: 990 LGQAQLAGL----GQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSI 1045
G + L G I T+ GL +AA + + H
Sbjct: 673 -GHTDMVTLLLDKGANIHMSTKSGLTSLH------------LAAQEDKVNVADILTKH-- 717
Query: 1046 AASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLER 1105
D DA T+ + T L +AC G+ ++V LL++
Sbjct: 718 --------------------------GADQDAHTKLGY-TPLIVACHYGNVKMVNFLLKQ 750
Query: 1106 GASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEV 1165
GA++ + K G+TPL AA GH ++ +LL +GA A + +T L++A G V
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA-TTANGNTALAIAKRLGYISV 809
Query: 1166 VELL 1169
V+ L
Sbjct: 810 VDTL 813
Score = 174 bits (440), Expect = 1e-42
Identities = 158/550 (28%), Positives = 257/550 (46%), Gaps = 26/550 (4%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
I A TES T + +A GH +V LL+ GAS + + +G T L +AA AG V VV
Sbjct: 424 IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
LL NGA ++A++ R + TPL +A G+ E+V+LLL A+ + + YTPL ++A G
Sbjct: 483 LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
V++ +LL AGA + T K G +PL +AA G KLLL + ++ + N T
Sbjct: 542 QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 598
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
L +A +V LLL++ A+ AK G TPL AA ++ LL+ GA+ N
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 657
Query: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
V T L +A+ +GH LL+ +GA+I + K G T L LAA ++V +L +
Sbjct: 658 -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716
Query: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1434
GAD DA TPL+ A G+VK+V +L+K+ +++ +
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV--NAKTKNGYTPLHQAAQQGHT 774
Query: 1435 HLCMESIVQAKDRQAAEANKNASILLEE-------LDLEKLREESRRLALAAKREKRKEK 1487
H+ + A AN N ++ + + +D K+ E EK
Sbjct: 775 HIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKH--- 831
Query: 1488 RRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISAT 1547
K E ++ ++E + E L+ ED E L + ++ G++
Sbjct: 832 ---KLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKE-LGDDSLPSSQFLDGMNYL 887
Query: 1548 WTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSS 1607
+L G R++++ + SS R + + + + DD + I Q + E++ +S
Sbjct: 888 RYSLEGG---RSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNS 944
Query: 1608 TSESGDSDNM 1617
S ++N+
Sbjct: 945 YRLSWGTENL 954
Score = 172 bits (436), Expect = 4e-42
Identities = 138/405 (34%), Positives = 195/405 (48%), Gaps = 81/405 (20%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
+D+ T+ + TAL +A G E+V+ L++ GA+I + + GFTPL +AA H+ VV+
Sbjct: 90 VDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
Query: 1135 LLDNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGANKEHR------------- 1179
LL+NGA+ QS T+D TPL++A G + V +LL + R
Sbjct: 149 LLENGAN---QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT 205
Query: 1180 ------------------------NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGS 1215
S +TPL +AA G VN+ +LLN GA ++ +
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT--A 263
Query: 1216 KLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRK 1275
+ GI+PL +A+ G+T VKLLLD G I+A+ T L A G +VV LLL+R
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-TPLHCAARSGHDQVVELLLERG 322
Query: 1276 ANVEHRAKTGLTPLMEAASGGYAE---------------------------------VGR 1302
A + R K GL+PL AA G + E V +
Sbjct: 323 APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK 382
Query: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362
+LLDK A+ NA + T L IA K K ELL+ GA I + G TP+ +AA
Sbjct: 383 LLLDKRANPNARALNGF--TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 440
Query: 1363 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
GHL++V LL+Q GA D + R T L A R G V+VVR L++
Sbjct: 441 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485
Score = 171 bits (433), Expect = 9e-42
Identities = 122/334 (36%), Positives = 185/334 (55%), Gaps = 9/334 (2%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
++ TES T L +A G+ + LL RGA+++ + G TPL +A+ G+ +V++
Sbjct: 226 VNRTTESGF-TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 284
Query: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
LLD G I+A++ R TPL A G +VVELLL RGA R + +PL +AA G
Sbjct: 285 LLDRGGQIDAKT-RDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
+V +K LL A ++ T L + L +AA GH KLLLD ++ NA+ N T
Sbjct: 344 HVECVKHLLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDKRANPNAR-ALNGFT 400
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
L +AC + R +V+ LL+ A+++ ++GLTP+ AA G+ + +LL GA +P
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA---SP 457
Query: 1315 PVPSSR-DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373
V + R +TAL +AA G + L+ GA +D R ++ TPL +A+ G ++VQLL+
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 1374 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Q A DAA TPL + R+G V V L++
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
Score = 163 bits (412), Expect = 2e-39
Identities = 112/354 (31%), Positives = 193/354 (54%), Gaps = 20/354 (5%)
Query: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139
+S+ + + A G+ + V L+ G I ++ G L LAA GHVG+V+ LL G
Sbjct: 28 KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
Query: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199
+ +++ +++ +T L +A G+ EVV++L+ GAN ++ + +TPL +AA +++++
Sbjct: 88 SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1259
K LL GA N T ++ G +PL +A GH AV +LL+ +D ++ R AL +A
Sbjct: 147 KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 199
Query: 1260 CFQGRTEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1311
+ T+ +LLL N + ++K +G TPL AA G V +LL++GA V
Sbjct: 200 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
Query: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
+ + T L +A+ +G+ +LL+ RG ID + + G TPL AA GH VV+L
Sbjct: 260 DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
Query: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATI 1425
L++ GA + A ++PL A + HV+ V++L++ ++ P D + Y+ +
Sbjct: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 369
Score = 153 bits (387), Expect = 2e-36
Identities = 115/331 (34%), Positives = 169/331 (51%), Gaps = 10/331 (3%)
Query: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
T N T L +A G+ +V+ LL+RG I+ + + G TPL AA +GH VVE+LL+
Sbjct: 262 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
Query: 1139 GADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 1196
GA + A RTK+ +PL +A G E V+ LL A + + T L +AA G+
Sbjct: 322 GAPLLA---RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378
Query: 1197 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1256
+ K+LL+ A N+R + G +PL +A ++LL+ G+ I A E+ T +
Sbjct: 379 RVTKLLLDKRANPNARALN--GFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPI 435
Query: 1257 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316
+A F G +V LLL A+ + G T L AA G EV R LL GA V+A
Sbjct: 436 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR-- 493
Query: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376
T L IA+ G + +LL+ AH D G TPL ++A G +DV +L++AG
Sbjct: 494 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
Query: 1377 ADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
A A + TPL A + G + V + L++
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Score = 76.6 bits (187), Expect = 3e-13
Identities = 53/180 (29%), Positives = 92/180 (51%), Gaps = 10/180 (5%)
Query: 1290 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1349
+ AA G + L G D+N + AL +AA +GH + L+GRG+ +D
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINT--CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 1350 NKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE- 1408
KKGNT L +A+ G +VV++LV+ GA+++A TPL A ++ H+ VV+YL++
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 1409 VNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAA-------EANKNASILLE 1461
NQ + + +A + + + +E+ + K R A + K+A++LL+
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Score = 47.8 bits (112), Expect = 1e-04
Identities = 36/95 (37%), Positives = 49/95 (51%), Gaps = 2/95 (2%)
Query: 1315 PVPSSRDTALTIAADKGHY-KFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373
P S + + AA G+ K E L G G I+ N+ G L LAA GH+ +VQ L+
Sbjct: 26 PKKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELL 84
Query: 1374 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
G+ VD+A + T L A G +VV+ LVKE
Sbjct: 85 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 249 bits (637), Expect = 2e-65
Identities = 166/475 (34%), Positives = 267/475 (56%), Gaps = 8/475 (1%)
Query: 243 SEGD-VNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
++GD V V+ LL V++ T + + L +A G+Y + ++LL AN R + G
Sbjct: 340 AQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG- 398
Query: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
TPL A +K+++LL+ + A + A + +G T + A G++++V +LL++GAS +
Sbjct: 399 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
N G T L A AG VEV R LL NGA ++ + E +++ L +A G E+V+ LL
Sbjct: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLL 517
Query: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481
+ A + T +T L + +G V+VA +LL++GA ++ +PL +AA G ++
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 577
Query: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
+A LL++R A+ + G TPL AA ++++ LLL +GA+ +A T + T L +A
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIA 636
Query: 542 CCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
+++A L+ GA+ + TPL A+QEGH ++V LL GAN+H +T +G
Sbjct: 637 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 696
Query: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
T+L A + +VAD+L + GAD + ++ G TPL+ A G+V V FL+ +GANVN
Sbjct: 697 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756
Query: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
T N +T L A GH ++ +LL HGA P +G+T L A + G+ SVV
Sbjct: 757 KT-KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Score = 221 bits (563), Expect = 7e-57
Identities = 174/529 (32%), Positives = 264/529 (49%), Gaps = 23/529 (4%)
Query: 235 NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 294
N S A G+++ V + L G +N + G + L LA G+ L Q LL ++V+
Sbjct: 32 NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91
Query: 295 DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354
KG+ T L A+ G ++VK+L+ A++NAQS G T L A ++DVVK LL
Sbjct: 92 SATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150
Query: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414
E+GA+ E+G TPL A GH + +LLEN + + AL +A K
Sbjct: 151 ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT-----KGKVRLPALHIAARKDDT 205
Query: 415 EMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466
+ LL + AD + K T+ T L A G+V VA LLL+ GA V+ A +
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
Query: 467 FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526
+PL +A+ G+ + LL++RG ++ +G TPL AAR GH+++V LLL +GA +
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Query: 527 NAQTEETQETALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYL 583
A+T+ + L +A G +E L++ A D+ L T L AA GH + K L
Sbjct: 326 LARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Query: 584 LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHV 643
L AN +A G T L AC+ V ++L++ GA ++ +E G TP+ AA GH+
Sbjct: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444
Query: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703
V L+ GA+ + T + T L +A G + VV LL +GA R ++ T L
Sbjct: 445 NIVLLLLQNGASPDVTNIRGE-TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503
Query: 704 AAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQAL 752
A++ G T +V LL + ++ P T P H R +V V ++
Sbjct: 504 ASRLGKTEIVQLLLQH----MAHPDAATTNGYTPLHISAREGQVDVASV 548
Score = 217 bits (553), Expect = 1e-55
Identities = 169/489 (34%), Positives = 246/489 (50%), Gaps = 13/489 (2%)
Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
A G+ N V+ LL G ++ T +G + L A +G+ ++ ++LL A + R K
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKN 331
Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
++PL AA G HV+ VK LL HKA V+ + TAL A G+ V K+LL+ A+
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT---LACYKGHLEMV 417
NG TPL A ++V LL++ GA I ES LT +A + GHL +V
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 447
Query: 418 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 477
LL+ GA + TAL A G VEV R LL +GA V+ A ++PL +A+
Sbjct: 448 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507
Query: 478 GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETA 537
G E+ LL++ A + GYTPL +AREG ++ ++LL GA + T++ T
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF-TP 566
Query: 538 LTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATT 594
L +A G L+VA L++ A + TPL AA + ++ LL GA+ HAT
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 595 ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGA 654
G T L A + +A LL GA+ ++ G TPL A++ GH V L+ KGA
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
Query: 655 NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
N++ +T + T L LA + V ++L HGAD K G T LI A G+ +V
Sbjct: 687 NIHMSTKSG-LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 745
Query: 715 YLLDYPNNL 723
+LL N+
Sbjct: 746 FLLKQGANV 754
Score = 215 bits (547), Expect = 5e-55
Identities = 168/518 (32%), Positives = 259/518 (50%), Gaps = 12/518 (2%)
Query: 221 RMRAESTANAGQSDNRSLAEACSEGDVNA-VRKLLIEGRSVNEHTEEGESLLCLACSAGY 279
++R + A + D+ A + D NA V+ ++ VN TE G + L +A G
Sbjct: 190 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM----VNRTTESGFTPLHIAAHYGN 245
Query: 280 YELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALT 339
+A +LL A V+ G ITPL A+ G+ +VKLLL ++A++ G T L
Sbjct: 246 VNVATLLLNRGAAVDFTARNG-ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH 304
Query: 340 YACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE 399
A G+ VV++LLE GA + +NG +PL A HVE + LL++ A ++ + +
Sbjct: 305 CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD 364
Query: 400 FKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ 459
+ +AL +A + GH + + LL+ A+ + T L AC ++V LL+ GA
Sbjct: 365 YL-TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423
Query: 460 VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALL 519
+ +S +P+ +AA GH+ + LL++ GAS + N G T L AAR G E+V L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 520 LGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGH 576
L GA ++A+ E Q T L +A G E+ L++ A + + TPL +A+EG
Sbjct: 484 LRNGALVDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 542
Query: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
+++ LL AGA T G T L A + G DVA +LLQ A + + G TPL
Sbjct: 543 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602
Query: 637 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD 696
AA + L+ KGA+ + TA N +T L +A + + LL +GA+ K
Sbjct: 603 AAHYDNQKVALLLLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 661
Query: 697 GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQL 734
G T L A++ GHT +V LLD N+ + +T L
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699
Score = 209 bits (531), Expect = 4e-53
Identities = 192/598 (32%), Positives = 274/598 (45%), Gaps = 51/598 (8%)
Query: 232 QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 291
Q+ +L A EG V V++LL G SV+ T++G + L +A AG E+ +VL+ A
Sbjct: 62 QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA 121
Query: 292 NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351
N+ + G TPL AA H+ +VK LL + A+ + + G T L A G+ V
Sbjct: 122 NINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 352 VLLESGAS------------------------IEDHN-------------ENGHTPLMEA 374
+LLE+ DHN E+G TPL A
Sbjct: 181 ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240
Query: 375 GSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDE 433
G+V VA LLL GA ++ T N + L +A +G+ MV+ LL+ G + KT +
Sbjct: 241 AHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298
Query: 434 MHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASL 493
T L A GH +V LLL+ GA + + SPL +AA G HVE L++ A +
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 358
Query: 494 EEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFL 553
++V + T L AA GH + LLL + AN NA+ T L +AC ++V + L
Sbjct: 359 DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKVMELL 417
Query: 554 IKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHT 610
+K GA I+ TP+ AA GHL +V LL GA+ T G+TAL A G
Sbjct: 418 VKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQV 477
Query: 611 DVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSL 670
+V LL+ GA ++ + +TPL A+R G VQ L+ A+ + T N +T L +
Sbjct: 478 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG-YTPLHI 536
Query: 671 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPD 730
+ G + V +LL GA + K G T L AAK G V LL SA
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596
Query: 731 VTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHL 788
+T L +H N+ AL ++ P N T L I K Q +S+ L
Sbjct: 597 LTPLHVAAHYDNQK-----VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Score = 199 bits (506), Expect = 3e-50
Identities = 160/483 (33%), Positives = 241/483 (49%), Gaps = 16/483 (3%)
Query: 193 KAFADPEVLRRLTS---SVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA 249
KA D L LT+ + C L RA A A + L AC + +
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413
Query: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309
+ L+ G S+ TE G + + +A G+ + +LL A+ + I+G+ T L AA
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAA 472
Query: 310 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT 369
G V++V+ LL + A V+A++ T L A G ++V++LL+ A + NG+T
Sbjct: 473 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 532
Query: 370 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKE--SALTLACYKGHLEMVRFLLEAGADQ 427
PL + G V+VA +LLE GA HS K+ + L +A G L++ + LL+ A
Sbjct: 533 PLHISAREGQVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Query: 428 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 487
+ T L A + +VA LLL+ GA + A + +PL +AA +++A+ L+
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Query: 488 ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
GA V +G TPL A++EGH +MV LLL +GANI+ T+ T+L LA +
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKV 708
Query: 548 EVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604
VAD L K GAD + TPL+ A G++++V +LL GANV+A T G T L A
Sbjct: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
Query: 605 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL--ISKGANVNRTTAN 662
+ GHT + +VLLQ GA + G T L A R G++ V L +++ TT
Sbjct: 769 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT 828
Query: 663 NDH 665
H
Sbjct: 829 EKH 831
Score = 191 bits (486), Expect = 6e-48
Identities = 217/844 (25%), Positives = 354/844 (41%), Gaps = 100/844 (11%)
Query: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGA 425
+ + + A AG+++ L+ G INT N+ +AL LA +GH+ +V+ LL G+
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 426 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 485
+ T + +TAL A + G EV ++L+ GA +N + + +PL +AA H+++
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
Query: 486 LIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ---------GANINAQTEETQET 536
L+E GA+ ++G+TPL A ++GH + VA+LL +I A+ ++T+
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
Query: 537 ALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTAT 596
AL L + ++ + TPL AA G++ + LL GA V T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
Query: 597 GDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANV 656
G T L A + G+T++ +LL G ++ ++ G TPL AAR+GH V+ L+ +GA +
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Query: 657 NRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716
T N + L +A G H+ V+ LL H A D T L AA GH V L
Sbjct: 326 LART-KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Query: 717 LDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQAL-----PMVVPPQEPDKPPANVA-- 769
LD N P P H + R+ V L + E P +VA
Sbjct: 385 LDKRAN----PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 440
Query: 770 ------TTLPIRNKAAS-----KQKSSSHLPANSQDVQGYITNQSPESIVE-EAQGKLTE 817
L ++N A+ + +++ H+ A + V+ ++V+ A+ + T
Sbjct: 441 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 500
Query: 818 LEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELN-KTREEQIQKKQKILEELQKVEREL 876
L + + QL +AH D T L+ RE Q+ +LE L
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE--AGAAHSL 558
Query: 877 QLK---TQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVD 933
K T + +Y + ++ LQ++ LTP+ V A L
Sbjct: 559 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL---- 614
Query: 934 PVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGPLPPGSIANLTELQGV----IVGQPV 989
+L K A+ G+ P+ A + +A+ L G+ N+ QGV + Q
Sbjct: 615 -LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE- 672
Query: 990 LGQAQLAGL----GQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSI 1045
G + L G I T+ GL +AA + + H
Sbjct: 673 -GHTDMVTLLLDKGANIHMSTKSGLTSLH------------LAAQEDKVNVADILTKH-- 717
Query: 1046 AASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLER 1105
D DA T+ + T L +AC G+ ++V LL++
Sbjct: 718 --------------------------GADQDAHTKLGY-TPLIVACHYGNVKMVNFLLKQ 750
Query: 1106 GASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEV 1165
GA++ + K G+TPL AA GH ++ +LL +GA A + +T L++A G V
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA-TTANGNTALAIAKRLGYISV 809
Query: 1166 VELL 1169
V+ L
Sbjct: 810 VDTL 813
Score = 174 bits (440), Expect = 1e-42
Identities = 158/550 (28%), Positives = 257/550 (46%), Gaps = 26/550 (4%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
I A TES T + +A GH +V LL+ GAS + + +G T L +AA AG V VV
Sbjct: 424 IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
LL NGA ++A++ R + TPL +A G+ E+V+LLL A+ + + YTPL ++A G
Sbjct: 483 LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
V++ +LL AGA + T K G +PL +AA G KLLL + ++ + N T
Sbjct: 542 QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 598
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
L +A +V LLL++ A+ AK G TPL AA ++ LL+ GA+ N
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 657
Query: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
V T L +A+ +GH LL+ +GA+I + K G T L LAA ++V +L +
Sbjct: 658 -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716
Query: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1434
GAD DA TPL+ A G+VK+V +L+K+ +++ +
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV--NAKTKNGYTPLHQAAQQGHT 774
Query: 1435 HLCMESIVQAKDRQAAEANKNASILLEE-------LDLEKLREESRRLALAAKREKRKEK 1487
H+ + A AN N ++ + + +D K+ E EK
Sbjct: 775 HIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKH--- 831
Query: 1488 RRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISAT 1547
K E ++ ++E + E L+ ED E L + ++ G++
Sbjct: 832 ---KLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKE-LGDDSLPSSQFLDGMNYL 887
Query: 1548 WTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSS 1607
+L G R++++ + SS R + + + + DD + I Q + E++ +S
Sbjct: 888 RYSLEGG---RSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNS 944
Query: 1608 TSESGDSDNM 1617
S ++N+
Sbjct: 945 YRLSWGTENL 954
Score = 172 bits (436), Expect = 4e-42
Identities = 138/405 (34%), Positives = 195/405 (48%), Gaps = 81/405 (20%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
+D+ T+ + TAL +A G E+V+ L++ GA+I + + GFTPL +AA H+ VV+
Sbjct: 90 VDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
Query: 1135 LLDNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGANKEHR------------- 1179
LL+NGA+ QS T+D TPL++A G + V +LL + R
Sbjct: 149 LLENGAN---QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT 205
Query: 1180 ------------------------NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGS 1215
S +TPL +AA G VN+ +LLN GA ++ +
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT--A 263
Query: 1216 KLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRK 1275
+ GI+PL +A+ G+T VKLLLD G I+A+ T L A G +VV LLL+R
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-TPLHCAARSGHDQVVELLLERG 322
Query: 1276 ANVEHRAKTGLTPLMEAASGGYAE---------------------------------VGR 1302
A + R K GL+PL AA G + E V +
Sbjct: 323 APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK 382
Query: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362
+LLDK A+ NA + T L IA K K ELL+ GA I + G TP+ +AA
Sbjct: 383 LLLDKRANPNARALNGF--TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 440
Query: 1363 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
GHL++V LL+Q GA D + R T L A R G V+VVR L++
Sbjct: 441 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485
Score = 171 bits (433), Expect = 9e-42
Identities = 122/334 (36%), Positives = 185/334 (55%), Gaps = 9/334 (2%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
++ TES T L +A G+ + LL RGA+++ + G TPL +A+ G+ +V++
Sbjct: 226 VNRTTESGF-TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 284
Query: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
LLD G I+A++ R TPL A G +VVELLL RGA R + +PL +AA G
Sbjct: 285 LLDRGGQIDAKT-RDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
+V +K LL A ++ T L + L +AA GH KLLLD ++ NA+ N T
Sbjct: 344 HVECVKHLLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDKRANPNAR-ALNGFT 400
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
L +AC + R +V+ LL+ A+++ ++GLTP+ AA G+ + +LL GA +P
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA---SP 457
Query: 1315 PVPSSR-DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373
V + R +TAL +AA G + L+ GA +D R ++ TPL +A+ G ++VQLL+
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 1374 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Q A DAA TPL + R+G V V L++
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
Score = 163 bits (412), Expect = 2e-39
Identities = 112/354 (31%), Positives = 193/354 (54%), Gaps = 20/354 (5%)
Query: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139
+S+ + + A G+ + V L+ G I ++ G L LAA GHVG+V+ LL G
Sbjct: 28 KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
Query: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199
+ +++ +++ +T L +A G+ EVV++L+ GAN ++ + +TPL +AA +++++
Sbjct: 88 SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1259
K LL GA N T ++ G +PL +A GH AV +LL+ +D ++ R AL +A
Sbjct: 147 KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 199
Query: 1260 CFQGRTEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1311
+ T+ +LLL N + ++K +G TPL AA G V +LL++GA V
Sbjct: 200 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
Query: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
+ + T L +A+ +G+ +LL+ RG ID + + G TPL AA GH VV+L
Sbjct: 260 DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
Query: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATI 1425
L++ GA + A ++PL A + HV+ V++L++ ++ P D + Y+ +
Sbjct: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 369
Score = 153 bits (387), Expect = 2e-36
Identities = 115/331 (34%), Positives = 169/331 (51%), Gaps = 10/331 (3%)
Query: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
T N T L +A G+ +V+ LL+RG I+ + + G TPL AA +GH VVE+LL+
Sbjct: 262 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
Query: 1139 GADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 1196
GA + A RTK+ +PL +A G E V+ LL A + + T L +AA G+
Sbjct: 322 GAPLLA---RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378
Query: 1197 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1256
+ K+LL+ A N+R + G +PL +A ++LL+ G+ I A E+ T +
Sbjct: 379 RVTKLLLDKRANPNARALN--GFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPI 435
Query: 1257 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316
+A F G +V LLL A+ + G T L AA G EV R LL GA V+A
Sbjct: 436 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR-- 493
Query: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376
T L IA+ G + +LL+ AH D G TPL ++A G +DV +L++AG
Sbjct: 494 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
Query: 1377 ADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
A A + TPL A + G + V + L++
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Score = 76.6 bits (187), Expect = 3e-13
Identities = 53/180 (29%), Positives = 92/180 (51%), Gaps = 10/180 (5%)
Query: 1290 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1349
+ AA G + L G D+N + AL +AA +GH + L+GRG+ +D
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINT--CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 1350 NKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE- 1408
KKGNT L +A+ G +VV++LV+ GA+++A TPL A ++ H+ VV+YL++
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 1409 VNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAA-------EANKNASILLE 1461
NQ + + +A + + + +E+ + K R A + K+A++LL+
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Score = 47.8 bits (112), Expect = 1e-04
Identities = 36/95 (37%), Positives = 49/95 (51%), Gaps = 2/95 (2%)
Query: 1315 PVPSSRDTALTIAADKGHY-KFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373
P S + + AA G+ K E L G G I+ N+ G L LAA GH+ +VQ L+
Sbjct: 26 PKKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELL 84
Query: 1374 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
G+ VD+A + T L A G +VV+ LVKE
Sbjct: 85 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
Score = 42.0 bits (97), Expect = 0.008
Identities = 57/238 (23%), Positives = 97/238 (40%), Gaps = 18/238 (7%)
Query: 1484 RKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIG 1543
+K RRK KE+Q++K E ++A + E EL+ +E L ++P + EP T+
Sbjct: 1701 KKPVRRKLKEKQKQKEEGLQA-SAEKAELKKGSSEESL--GEDPGLAPEPLPTVKATSPL 1757
Query: 1544 ISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGES 1603
I T GS + + + ++K+ P V+ D P ++ +P S
Sbjct: 1758 IE---ETPIGSIKDKVKALQKRVEDEQKGRSKL-PIRVKGKEDVPKKTTH-RPHPAASPS 1812
Query: 1604 KSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEE 1663
S G S ++ S +SS K++ H P V+ + ++K V + E
Sbjct: 1813 LKSERHAPGSP-----SPKTERHSTLSSSAKTERHPP--VSPSSKTEKHSPVSPSAKTER 1865
Query: 1664 RKSVSGKASIKLSETISEGTS---NSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREE 1718
S + + +S T +S + TK+ P SP+GK P R E
Sbjct: 1866 HSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTE 1923
Score = 38.5 bits (88), Expect = 0.087
Identities = 43/151 (28%), Positives = 59/151 (39%), Gaps = 20/151 (13%)
Query: 2030 PMPTAKEHYPVSSPSSPSPPAQPGGVS----RNSPLDCGSASPN--KVASSSEQEAGSP- 2082
P T +P +SPS S PG S R+S L + + V+ SS+ E SP
Sbjct: 1798 PKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPV 1857
Query: 2083 -PVVETTNTRPPNSSS-----SSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMT 2136
P +T P +SSS S S S + + P S E PP V P
Sbjct: 1858 SPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPP-----VSPSGKTDK 1912
Query: 2137 VPPLATSSAPVAVPSTAP--VTYPMPQTPMG 2165
PP++ S P +P +P +P G
Sbjct: 1913 RPPVSPSGRTEKHPPVSPGRTEKRLPVSPSG 1943
Score = 35.4 bits (80), Expect = 0.74
Identities = 45/204 (22%), Positives = 75/204 (36%), Gaps = 33/204 (16%)
Query: 1970 TTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATY 2029
TT A++ S +P SPS + + T+ +S+A T + ++ T +
Sbjct: 1801 TTHRPHPAASPSLKSERHAPGSPSPKTERHSTL--SSSAKTERHPPVSPSSKTEKHSPVS 1858
Query: 2030 PMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVET-- 2087
P + H P SS S ++SP+ + + SS + PPV +
Sbjct: 1859 PSAKTERHSPASSSSK---------TEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGK 1909
Query: 2088 TNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPV 2147
T+ RPP S SG + H PP+ + E R+ V P +
Sbjct: 1910 TDKRPP--VSPSGRTEKH---------------PPVSPGRT---EKRLPVSPSGRTDKHQ 1949
Query: 2148 AVPSTAPVTYPMPQTPMGCPQPTP 2171
V + +P +P G + P
Sbjct: 1950 PVSTAGKTEKHLPVSPSGKTEKQP 1973
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 232 bits (592), Expect = 3e-60
Identities = 165/486 (33%), Positives = 255/486 (52%), Gaps = 12/486 (2%)
Query: 245 GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD-IT 303
G V LL + T+ G S L +A + Q+LL + V+D + D +T
Sbjct: 312 GHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDD--VTNDYLT 369
Query: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH 363
L AA+ GH K+ K+LL KA+ NA++ G T L AC + V+++LL+ GASI+
Sbjct: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
Query: 364 NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA 423
E+G TP+ A GHV + L+ +GA NT +N E+AL +A G E+VR+L++
Sbjct: 430 TESGLTPIHVAAFMGHVNIVSQLMHHGASPNT-TNVRGETALHMAARSGQAEVVRYLVQD 488
Query: 424 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 483
GA E K + T L + G ++ + LL GA N S +PL L+A GH ++A
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
Query: 484 ALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACC 543
A L++ GASL +G+TPL AA+ G E+ LLL + A+ +A ++ T L +A
Sbjct: 549 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA-AGKSGLTPLHVAAH 607
Query: 544 GGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
+VA L+ GA TPL AA++ +++ LL GA+ +A T G +
Sbjct: 608 YDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIAS 667
Query: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
+ A + GH D+ +LL A++ ++ G TPL AA+ V + L+++GA+V+ T
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727
Query: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD-- 718
+T L + C G++ +V LL H A + K+G T L +AA+ GHT ++ LL
Sbjct: 728 KMG-YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNN 786
Query: 719 -YPNNL 723
PN L
Sbjct: 787 ASPNEL 792
Score = 229 bits (585), Expect = 2e-59
Identities = 162/510 (31%), Positives = 264/510 (51%), Gaps = 18/510 (3%)
Query: 208 VSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGD-VNAVRKLLIEGRSVNEHTEE 266
V LD AA L++ + + S ++GD +N V+ LL V++ T +
Sbjct: 317 VEMLLDRAAPILSKTK----------NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTND 366
Query: 267 GESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKAD 326
+ L +A G+Y++A+VLL AN + + G TPL A +K+++LLL H A
Sbjct: 367 YLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG-FTPLHIACKKNRIKVMELLLKHGAS 425
Query: 327 VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
+ A + +G T + A G+V++V L+ GAS N G T L A +G EV R L
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Query: 387 LENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH 446
+++GA + + + ++ L ++ G ++V+ LL+ GA T +T L + +GH
Sbjct: 486 VQDGAQVEAKAKD-DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGH 544
Query: 447 VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLME 506
+VA LLD GA +++ +PL +AA G +E+A LL+++ AS + G TPL
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
Query: 507 AAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCST 566
AA ++++ LLL QGA+ +A + T L +A +++A L++ GAD
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGY-TPLHIAAKKNQMDIATTLLEYGADANAVTRQ 663
Query: 567 PLME---AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 623
+ AAQEGH+++V LL ANV+ + +G T L A + +VA+VL+ GA +
Sbjct: 664 GIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV 723
Query: 624 EHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELL 683
+ +++ G TPL G++ V FL+ A VN T N +T L A GH ++ +L
Sbjct: 724 DAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT-KNGYTPLHQAAQQGHTHIINVL 782
Query: 684 LAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
L + A P +G+T L A + G+ SVV
Sbjct: 783 LQNNASPNELTVNGNTALGIARRLGYISVV 812
Score = 215 bits (547), Expect = 5e-55
Identities = 174/541 (32%), Positives = 263/541 (48%), Gaps = 38/541 (7%)
Query: 232 QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 291
Q+ +L A EG V V +LL +V+ T++G + L +A AG E+ +VL+ A
Sbjct: 72 QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGA 131
Query: 292 NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351
NV + G TPL AA H+++VK LL + A + + G T L A G+ VV
Sbjct: 132 NVNAQSQNG-FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190
Query: 352 VLLES---------------------GASIEDHNEN--------GHTPLMEAGSAGHVEV 382
+LLE+ A++ N+N G TPL A G++ V
Sbjct: 191 LLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINV 250
Query: 383 ARLLLENGAGIN-THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEA 441
A LLL A ++ T N+ + L +A +G+ MV+ LL+ GA + KT + T L
Sbjct: 251 ATLLLNRAAAVDFTARNDI--TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG 308
Query: 442 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGY 501
GH +V +LLD A + + SPL +A G H+ LL++ +++V ++
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL 368
Query: 502 TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561
T L AA GH ++ +LL + AN NA+ T L +AC ++V + L+K GA I+
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKA-LNGFTPLHIACKKNRIKVMELLLKHGASIQ 427
Query: 562 LGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
TP+ AA GH+ +V L+ GA+ + T G+TAL A +G +V L+Q
Sbjct: 428 AVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQ 487
Query: 619 AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLA 678
GA +E +++ +TPL +AR G VQ L+ +GA+ N T + +T L L+ GH
Sbjct: 488 DGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG-YTPLHLSAREGHED 546
Query: 679 VVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPS 738
V LL HGA + K G T L AAK G V LL + +A +T L +
Sbjct: 547 VAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAA 606
Query: 739 H 739
H
Sbjct: 607 H 607
Score = 201 bits (512), Expect = 6e-51
Identities = 162/515 (31%), Positives = 246/515 (47%), Gaps = 38/515 (7%)
Query: 235 NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 294
NR L E +E + RK R + ++ S L A AG+ E A + ++
Sbjct: 11 NRDL-EINAEEEPEKKRKHRKRSRDRKKKSDANASYL-RAARAGHLEKALDYIKNGVDIN 68
Query: 295 DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354
G + L A+ GHV++V LL +A+V+A + GNTAL A G +VVKVL+
Sbjct: 69 ICNQNG-LNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLV 127
Query: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414
+GA++ ++NG TPL A H+EV + LL+NGA + + E + L +A +GH
Sbjct: 128 TNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLAVALQQGHD 186
Query: 415 EMVRFLLEAGADQEHKTDEMH-----------------------------TALMEACMDG 445
++V LLE + + +H T L A G
Sbjct: 187 QVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYG 246
Query: 446 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLM 505
++ VA LLL+ A V+ A + +PL +A+ G+ + LL++RGA ++ +G TPL
Sbjct: 247 NINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLH 306
Query: 506 EAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA---DIEL 562
AR GHE++V +LL + A I ++T+ + L +A G L L++ D+
Sbjct: 307 CGARSGHEQVVEMLLDRAAPILSKTKNGL-SPLHMATQGDHLNCVQLLLQHNVPVDDVTN 365
Query: 563 GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 622
T L AA GH ++ K LL AN +A G T L AC+ V ++LL+ GA
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGAS 425
Query: 623 LEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVEL 682
++ +E G TP+ AA GHV V L+ GA+ N T + T L +A G VV
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE-TALHMAARSGQAEVVRY 484
Query: 683 LLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
L+ GA + KD T L +A+ G +V LL
Sbjct: 485 LVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519
Score = 187 bits (476), Expect = 9e-47
Identities = 219/842 (26%), Positives = 360/842 (42%), Gaps = 116/842 (13%)
Query: 372 MEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKT 431
+ A AGH+E A ++NG IN N+ +AL LA +GH+E+V LL+ A+ + T
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAAT 104
Query: 432 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491
+ +TAL A + G EV ++L+ +GA VN + + +PL +AA H+E+ L++ GA
Sbjct: 105 KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
Query: 492 SLEEVNDEGYTPLMEAAREGHEEMVALLLGQ---------GANINAQTEETQETALTLAC 542
S ++G+TPL A ++GH+++V+LLL +I A+ ++T+ AL L
Sbjct: 165 SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN 224
Query: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
AD K+G TPL AA G++ + LL A V T T L
Sbjct: 225 DNN----ADVESKSG-------FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH 273
Query: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662
A + G+ ++ +LL GA ++ ++ G TPL AR+GH V+ L+ + A + T
Sbjct: 274 VASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT-K 332
Query: 663 NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722
N + L +A G HL V+LLL H D T L AA GH V LLD N
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
Query: 723 LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPM-----VVPPQEPDKPPANVATTL----- 772
P P H + R+ V L + + E P +VA +
Sbjct: 393 ----PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
Query: 773 --PIRNKAAS------KQKSSSHLPANS--QDVQGYITNQSPESIVEEAQGKLTELEQRI 822
+ + AS + +++ H+ A S +V Y+ + EA+ K + I
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ---VEAKAKDDQTPLHI 505
Query: 823 KEAIEKNAQLQSL--ELAHADQLTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKT 880
+ K +Q L + A + T L+ + E + + L L + T
Sbjct: 506 SARLGKADIVQQLLQQGASPNAATTSGYTPLHLSARE---GHEDVAAFLLDHGASLSITT 562
Query: 881 QQ-----QLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPV 935
++ + +Y +++ + LQ+ LTP+ V A L +
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALL-----L 617
Query: 936 LLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQL 995
L + AA+ G+ P+ A + +A L G+ AN QG+
Sbjct: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI------------ 665
Query: 996 AGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRAS--AMSN----TPTHSIAASI 1049
+ Q+G + D+++ + GR + +SN TP H A
Sbjct: 666 ----ASVHLAAQEGHV-------------DMVSLLLGRNANVNLSNKSGLTPLHLAA--- 705
Query: 1050 SQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASI 1109
+ + +++ A +DAQT+ + T L + C G+ ++V LL+ A +
Sbjct: 706 QEDRVNVAEVLVNQGA--------HVDAQTKMGY-TPLHVGCHYGNIKIVNFLLQHSAKV 756
Query: 1110 EHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT--KDTPLSLACSGGRQEVVE 1167
+ K G+TPL AA GH ++ +LL N A + +E T +T L +A G VV+
Sbjct: 757 NAKTKNGYTPLHQAAQQGHTHIINVLLQNNA---SPNELTVNGNTALGIARRLGYISVVD 813
Query: 1168 LL 1169
L
Sbjct: 814 TL 815
Score = 187 bits (476), Expect = 9e-47
Identities = 144/471 (30%), Positives = 226/471 (47%), Gaps = 8/471 (1%)
Query: 199 EVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGR 258
+ L L + C + A L +A A A + L AC + + + LL G
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKA-LNGFTPLHIACKKNRIKVMELLLKHGA 424
Query: 259 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVK 318
S+ TE G + + +A G+ + L+ A+ ++G+ T L AA G ++V+
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE-TALHMAARSGQAEVVR 483
Query: 319 LLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAG 378
L+ A V A++ T L + G D+V+ LL+ GAS +G+TPL + G
Sbjct: 484 YLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
Query: 379 HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL 438
H +VA LL++GA ++ + + + L +A G LE+ LL+ A + T L
Sbjct: 544 HEDVAAFLLDHGASLSITTKK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPL 602
Query: 439 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND 498
A + +VA LLLD GA + A + +PL +AA +++A L+E GA V
Sbjct: 603 HVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTR 662
Query: 499 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 558
+G + AA+EGH +MV+LLLG+ AN+N + ++ T L LA + VA+ L+ GA
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNL-SNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
Query: 559 DIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADV 615
++ TPL G++++V +LL A V+A T G T L A + GHT + +V
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781
Query: 616 LLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL-ISKGANVNRTTANNDH 665
LLQ A + G T L A R G++ V L I + TT H
Sbjct: 782 LLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKH 832
Score = 176 bits (447), Expect = 2e-43
Identities = 121/324 (37%), Positives = 177/324 (54%), Gaps = 16/324 (4%)
Query: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145
AL LA GH E+V LL+R A+++ KKG T L +A+ AG VV++L+ NGA++ AQ
Sbjct: 77 ALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
Query: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205
S+ TPL +A EVV+ LL GA++ +TPL++A G+ ++ +LL
Sbjct: 137 SQ-NGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL-- 193
Query: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN-TALTLACFQGR 1264
+ T K+ + L +AA T A LLL +D NA +E+ T L +A G
Sbjct: 194 ----ENDTKGKVRLPALHIAARKDDTKAAALLLQ--NDNNADVESKSGFTPLHIAAHYGN 247
Query: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD--T 1322
V +LLL+R A V+ A+ +TPL A+ G A + ++LLD+GA ++A +RD T
Sbjct: 248 INVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDA----KTRDGLT 303
Query: 1323 ALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAA 1382
L A GH + E+L+ R A I + K G +PL +A G HL+ VQLL+Q VD
Sbjct: 304 PLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDV 363
Query: 1383 DNRKITPLMAAFRKGHVKVVRYLV 1406
N +T L A GH KV + L+
Sbjct: 364 TNDYLTALHVAAHCGHYKVAKVLL 387
Score = 176 bits (446), Expect = 3e-43
Identities = 118/333 (35%), Positives = 179/333 (53%), Gaps = 7/333 (2%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
I A TES T + +A GH +V L+ GAS + +G T L +AA +G VV
Sbjct: 426 IQAVTESGL-TPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
Query: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
L+ +GA +EA++ + TPL ++ G+ ++V+ LL +GA+ S YTPL L+A G
Sbjct: 485 LVQDGAQVEAKA-KDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
+ ++ LL+ GA ++ T K G +PL +AA G LLL + +A ++ T
Sbjct: 544 HEDVAAFLLDHGASLSITT--KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGL-T 600
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
L +A +V LLLD+ A+ AK G TPL AA ++ LL+ GAD NA
Sbjct: 601 PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA- 659
Query: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
V ++ +AA +GH LL+GR A++++ NK G TPL LAA ++V ++LV
Sbjct: 660 -VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVN 718
Query: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
GA VDA TPL G++K+V +L++
Sbjct: 719 QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ 751
Score = 171 bits (433), Expect = 9e-42
Identities = 132/399 (33%), Positives = 193/399 (48%), Gaps = 73/399 (18%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
++DA T+ + TAL +A G E+V+ L+ GA++ + + GFTPL +AA H+ VV+
Sbjct: 99 NVDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVK 157
Query: 1134 ILLDNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGA----------------- 1174
LLDNGA +QS T+D TPL++A G +VV LLL
Sbjct: 158 FLLDNGA---SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDD 214
Query: 1175 ------------NKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPL 1222
N + + S +TPL +AA G +N+ +LLN A ++ ++ I+PL
Sbjct: 215 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT--ARNDITPL 272
Query: 1223 MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1282
+A+ G+ VKLLLD G+ I+A+ T L G +VV +LLDR A + +
Sbjct: 273 HVASKRGNANMVKLLLDRGAKIDAKTRDGL-TPLHCGARSGHEQVVEMLLDRAAPILSKT 331
Query: 1283 KTGLTPLMEAASG---------------------------------GYAEVGRVLLDKGA 1309
K GL+PL A G G+ +V +VLLDK A
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
Query: 1310 DVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVV 1369
+ NA + T L IA K K ELL+ GA I + G TP+ +AA GH+++V
Sbjct: 392 NPNAKALNGF--TPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449
Query: 1370 QLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
L+ GA + + R T L A R G +VVRYLV++
Sbjct: 450 SQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488
Score = 158 bits (399), Expect = 8e-38
Identities = 110/323 (34%), Positives = 165/323 (51%), Gaps = 6/323 (1%)
Query: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145
AL +A + LL+ + + K GFTPL +AA G++ V +LL+ A ++
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
Query: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205
+ R TPL +A G +V+LLL RGA + + TPL A G+ ++++LL+
Sbjct: 265 A-RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDR 323
Query: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265
A I S+T K G+SPL +A H V+LLL ++ + + TAL +A G
Sbjct: 324 AAPILSKT--KNGLSPLHMATQGDHLNCVQLLLQHNVPVD-DVTNDYLTALHVAAHCGHY 380
Query: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1325
+V +LLD+KAN +A G TPL A +V +LL GA + A V S T +
Sbjct: 381 KVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA--VTESGLTPIH 438
Query: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1385
+AA GH L+ GA + N +G T L +AA G +VV+ LVQ GA V+A
Sbjct: 439 VAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKD 498
Query: 1386 KITPLMAAFRKGHVKVVRYLVKE 1408
TPL + R G +V+ L+++
Sbjct: 499 DQTPLHISARLGKADIVQQLLQQ 521
Score = 158 bits (399), Expect = 8e-38
Identities = 132/431 (30%), Positives = 205/431 (47%), Gaps = 18/431 (4%)
Query: 1027 MAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDID-AQTES---N 1082
+AA G + +S H + + + + T + + S + + D AQ E+ +
Sbjct: 439 VAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKD 498
Query: 1083 HDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADI 1142
T L ++ G ++VQ LL++GAS G+TPL L+A GH V LLD+GA +
Sbjct: 499 DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558
Query: 1143 EAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1202
+++ TPL +A G+ EV LLL + A+ + S TPL +AA + +L
Sbjct: 559 SITTKKGF-TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Query: 1203 LNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQ 1262
L+ GA + +K G +PL +AA LL+ G+D NA + ++ LA +
Sbjct: 618 LDQGA--SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA-VTRQGIASVHLAAQE 674
Query: 1263 GRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1322
G ++VSLLL R ANV K+GLTPL AA V VL+++GA V+A T
Sbjct: 675 GHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY--T 732
Query: 1323 ALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAA 1382
L + G+ K L+ A ++ + K G TPL AA GH ++ +L+Q A +
Sbjct: 733 PLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792
Query: 1383 DNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIV 1442
T L A R G++ VV L K V + E M T+T+K + M ++
Sbjct: 793 TVNGNTALGIARRLGYISVVDTL-KIVTE-----ETMT-TTTVTEKHKMNVPE-TMNEVL 844
Query: 1443 QAKDRQAAEAN 1453
D + +AN
Sbjct: 845 DMSDDEVRKAN 855
Score = 129 bits (324), Expect = 4e-29
Identities = 98/284 (34%), Positives = 140/284 (49%), Gaps = 10/284 (3%)
Query: 1123 AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 1182
AA AGH+ + NG DI ++ + L LA G EVV LL R AN +
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNA-LHLASKEGHVEVVSELLQREANVDAATKK 106
Query: 1183 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS 1242
T L +A+ G ++K+L+ GA +N++ S+ G +PL +AA H VK LLD G+
Sbjct: 107 GNTALHIASLAGQAEVVKVLVTNGANVNAQ--SQNGFTPLYMAAQENHLEVVKFLLDNGA 164
Query: 1243 DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1302
+ E T L +A QG +VVSLLL+ + + K L L AA +
Sbjct: 165 SQSLATEDGF-TPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAA 219
Query: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362
+LL D NA S T L IAA G+ LL+ R A +D + TPL +A+
Sbjct: 220 LLLQN--DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASK 277
Query: 1363 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
G+ ++V+LL+ GA +DA +TPL R GH +VV L+
Sbjct: 278 RGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLL 321
Score = 73.9 bits (180), Expect = 2e-12
Identities = 48/159 (30%), Positives = 83/159 (52%), Gaps = 2/159 (1%)
Query: 1249 ETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG 1308
+++ N + A G E + ++ + GL L A+ G+ EV LL +
Sbjct: 38 KSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQRE 97
Query: 1309 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDV 1368
A+V+A +TAL IA+ G + ++L+ GA+++ +++ G TPL++AA HL+V
Sbjct: 98 ANVDA--ATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEV 155
Query: 1369 VQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
V+ L+ GA A TPL A ++GH +VV L++
Sbjct: 156 VKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE 194
Score = 40.8 bits (94), Expect = 0.018
Identities = 110/508 (21%), Positives = 193/508 (37%), Gaps = 76/508 (14%)
Query: 1948 RHSNQNSSGSQVNSAGSLTSSPTTTTSSSA-STVPGTSTNGSPSSPSVRRQLFVTVVKTS 2006
R+S G S G+ S PTT + ST P S +P +TV +
Sbjct: 1468 RYSYLTEPGMIERSTGATRSLPTTYSYKPFFSTRPYQSWTTAP----------ITVPGPA 1517
Query: 2007 NATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSA 2066
+ T++++++SN P+A + S S+PSP G S S + S
Sbjct: 1518 KSGFTSLSSSSSNT-----------PSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISD 1566
Query: 2067 SPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQS 2126
+ + S S P+ + P N SSG+ + + P P L +
Sbjct: 1567 VASPIRSFRTM---SSPIKTVVSQSPYNIQVSSGTLA------RAPAVTEATPLKGLASN 1617
Query: 2127 QVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTT 2186
++ ++PV + + TP P+ M + ++ T+
Sbjct: 1618 ST-----------FSSRTSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITS 1666
Query: 2187 A------PHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSACQNSVHPANKP 2240
A P K+ S S+V V+S I S+ S V+ + + S+ P P
Sbjct: 1667 AAPLISSPLKSVVSPVKSAVDVISSAKITMASSLSSPVKQMPGHAEVALVNGSISPLKYP 1726
Query: 2241 IAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQS 2300
S+ L G +T S+ SVVS+ + + ++ +P S PL +S
Sbjct: 1727 ----SSSTLINGCKATATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFS-PL-RS 1780
Query: 2301 DTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYG-----PG 2355
S AP L+ P+ S + ++ S + T S T S+I +Y P
Sbjct: 1781 YVSAAPSAFQSLRTPSAS-ALYTSLGSSISATTSSVT------SSIITVPVYSVVNVLPE 1833
Query: 2356 APLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSP-----APSSVPLG 2410
L P + +F + S +LL+P + + ++ Q S +P APS++ L
Sbjct: 1834 PALKKLPDSNSFTK---SAAALLSPIKTLTTETHPQPHFSRTSSPVKSSLFLAPSALKLS 1890
Query: 2411 SEKPSNVSQDRKVPVPIGTERSARIRQT 2438
+ PS++S +++ + + +R T
Sbjct: 1891 T--PSSLSSSQEILKDVAEMKEDLMRMT 1916
Score = 36.2 bits (82), Expect = 0.43
Identities = 49/229 (21%), Positives = 75/229 (32%), Gaps = 36/229 (15%)
Query: 1934 PARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSA---STVP--------- 1981
P +AT SPK P H + N+ S++ + TTSS S +P
Sbjct: 3866 PIKAT-SPKDTFPPNHMS-NTKASKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHRDNI 3923
Query: 1982 -------GTSTNGSPSSPSVR----------RQLFVTVVKTSNATTTTVTTTASNNNTAP 2024
T G P + R VT T+ TTTT TTT + + T
Sbjct: 3924 IAVRKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVTTTTTTATTTTTTTTTTTTSCTVK 3983
Query: 2025 TNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSR-----NSPLDCGSASPNKVASSSEQEA 2079
+ K S +S S L S ++ S SE
Sbjct: 3984 VRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETSR 4043
Query: 2080 GSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQV 2128
G P V T + R + ++ S + + S P+ P +++ +
Sbjct: 4044 GGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDI 4092
Score = 33.1 bits (74), Expect = 3.7
Identities = 19/61 (31%), Positives = 31/61 (50%), Gaps = 2/61 (3%)
Query: 1349 RNKKG--NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
R KK N AA GHL+ ++ G D++ + + L A ++GHV+VV L+
Sbjct: 35 RKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELL 94
Query: 1407 K 1407
+
Sbjct: 95 Q 95
Score = 33.1 bits (74), Expect = 3.7
Identities = 85/416 (20%), Positives = 149/416 (35%), Gaps = 53/416 (12%)
Query: 1668 SGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRS 1727
SG S+ S + + S S + S PSP+ S G T +S K +V
Sbjct: 1519 SGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVK-------SISDVASPI 1571
Query: 1728 KKVSVPSTVISRVIGRGGCNINAIREFTG---AHIDIDKQKDKTGDRIITIRGGTESTRQ 1784
+ S+ I V+ + NI A + K + + R +T
Sbjct: 1572 RSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNSTFSSRTSPVTTAG 1631
Query: 1785 ATQLINALIKDPDKEIDELIPKNRLKSSSAN----SKIGSSAPTTTAANTSLMGIKMTTV 1840
+ +++ P PK+ + S++ S I S+AP ++ S++ + V
Sbjct: 1632 SLLERSSITMTPPAS-----PKSNINMYSSSLPFKSIITSAAPLISSPLKSVVSPVKSAV 1686
Query: 1841 ALSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPVSL------PLAYPPPQ-FAHA 1893
+ S+++ A ++ +PV + V+L PL YP +
Sbjct: 1687 DVISSAKITMA------------SSLSSPVKQMPGHAEVALVNGSISPLKYPSSSTLING 1734
Query: 1894 LLAAQTFQQ--IRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSN 1951
A T Q+ + + + P SP R+ S P +
Sbjct: 1735 CKATATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFSPLRSYVSAAPSAF-QSLR 1793
Query: 1952 QNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTT 2011
S+ + S GS S+ T++ +SS TVP S P++++ + SN+ T
Sbjct: 1794 TPSASALYTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKK------LPDSNSFTK 1847
Query: 2012 TVTTTASNNNTAPTNATYPMPTAKEHYP-VSSPSSPSPPAQPGGVSRNSPLDCGSA 2066
+ S T T T+P P H+ SSP S P + ++P S+
Sbjct: 1848 SAAALLSPIKTL-TTETHPQP----HFSRTSSPVKSSLFLAPSALKLSTPSSLSSS 1898
Score = 32.3 bits (72), Expect = 6.3
Identities = 49/185 (26%), Positives = 72/185 (38%), Gaps = 31/185 (16%)
Query: 1513 QAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNR 1572
Q + EK K + P L +T TT +AT TT T TTTS K R
Sbjct: 3933 QKQGQPEKGKAKQLPSKLPVKVRSTCVTTTTTTATTTTTT-------TTTTTTSCTVKVR 3985
Query: 1573 KNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDE----SSN 1628
K+++ + S + ++GE+ S + M+ S SDE S N
Sbjct: 3986 KSQL---------KEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQ-SELSDEEESTSRN 4035
Query: 1629 SNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLS 1688
++ S S P+V T + KK + + KS S KA SE S + S
Sbjct: 4036 TSLSETSRGGQPSVTTKSARDKKTEAAPL-------KSKSEKAG---SEKRSSRRTGPQS 4085
Query: 1689 TCTKS 1693
C ++
Sbjct: 4086 PCERT 4090
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 228 bits (580), Expect = 8e-59
Identities = 202/632 (31%), Positives = 299/632 (47%), Gaps = 51/632 (8%)
Query: 204 LTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEH 263
L ++ S LD+A L +T N Q+ L A EG V V +LL + +
Sbjct: 50 LRAARSGNLDKALDHLRNGVDINTCN--QNGLNGLHLASKEGHVKMVVELLHKEIILETT 107
Query: 264 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323
T++G + L +A AG E+ + L+ ANV + KG TPL AA H+++VK LL +
Sbjct: 108 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQENHLEVVKFLLEN 166
Query: 324 KADVNAQSSTGNTALTYACAGGYVDVV-----------------------------KVLL 354
A+ N + G T L A G+ +VV VLL
Sbjct: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 226
Query: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGH 413
++ + + ++ G TPL A ++ VA+LLL GA +N T N + L +A +G+
Sbjct: 227 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--TPLHIASRRGN 284
Query: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473
+ MVR LL+ GA E KT + T L A +GHV ++ +LLD GA + + SP+ +
Sbjct: 285 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 344
Query: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533
AA G H++ LL++ A ++++ + TPL AA GH + +LL +GA N++
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LN 403
Query: 534 QETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANV 590
T L +AC + V + L+K GA I+ TPL A+ GHL +VK LL GA+
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463
Query: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650
+ + +T L A GHT+VA LLQ A + +++ +TPL AAR GH V+ L+
Sbjct: 464 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 523
Query: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710
AN N T HT L +A GH+ V LL A K G T L AAK G
Sbjct: 524 ENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 582
Query: 711 SVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-PQEPDKPPANVA 769
V LL+ + +A +T L H N + + +++P P P N
Sbjct: 583 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRGGSPHSPAWNGY 636
Query: 770 TTLPIRNKAASKQKSSSHL----PANSQDVQG 797
T L I K + + S L AN++ VQG
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668
Score = 224 bits (571), Expect = 9e-58
Identities = 167/513 (32%), Positives = 257/513 (50%), Gaps = 16/513 (3%)
Query: 208 VSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
V LD A T+ + E T L A G V LL G + T+ G
Sbjct: 288 VRLLLDRGAQIETKTKDELTP---------LHCAARNGHVRISEILLDHGAPIQAKTKNG 338
Query: 268 ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADV 327
S + +A + + ++LL A ++D + +TPL AA+ GH ++ K+LL A
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLLDKGAKP 397
Query: 328 NAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLL 387
N+++ G T L AC +V V+++LL++GASI+ E+G TPL A GH+ + + LL
Sbjct: 398 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 457
Query: 388 ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447
+ GA N SN E+ L +A GH E+ ++LL+ A K + T L A GH
Sbjct: 458 QRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 516
Query: 448 EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507
+ +LLL++ A N+ + +PL +AA GHVE L+E+ AS + +G+TPL A
Sbjct: 517 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 576
Query: 508 AREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC--- 564
A+ G + LLL + A+ NA + T L +A L++ L+ G
Sbjct: 577 AKYGKVRVAELLLERDAHPNAAGKNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 635
Query: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
TPL AA++ +E+ + LL G + +A + G T L A + GH ++ +LL A+
Sbjct: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 695
Query: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
++ G TPL A+ GHV LI G V+ TT +T L +A G++ +V+ LL
Sbjct: 696 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG-YTPLHVASHYGNIKLVKFLL 754
Query: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
H AD + K G + L +AA+ GHT +V LL
Sbjct: 755 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 787
Score = 221 bits (564), Expect = 6e-57
Identities = 166/474 (35%), Positives = 242/474 (51%), Gaps = 8/474 (1%)
Query: 243 SEGD-VNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
++GD ++ VR LL +++ T + + L +A G++ +A+VLL A R + G
Sbjct: 346 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 404
Query: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
TPL A HV++++LLL A ++A + +G T L A G++ +VK LL+ GAS
Sbjct: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
Query: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
N TPL A AGH EVA+ LL+N A +N + + ++ L A GH MV+ LL
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 523
Query: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 524 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 583
Query: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
+A LL+ER A G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 584 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 642
Query: 542 CCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
+EVA L++ G TPL AAQEGH E+V LL+ AN + +G
Sbjct: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702
Query: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
T L + GH VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN
Sbjct: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762
Query: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
T ++ L A GH +V LLL +GA P DG+T L A + G+ SV
Sbjct: 763 KT-KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 815
Score = 220 bits (560), Expect = 2e-56
Identities = 169/509 (33%), Positives = 248/509 (48%), Gaps = 38/509 (7%)
Query: 246 DVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPL 305
++N + LL G SVN + G + L +A G + ++LL A +E + K ++TPL
Sbjct: 251 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK-TKDELTPL 309
Query: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
AA GHV+I ++LL H A + A++ G + + A G ++D V++LL+ A I+D
Sbjct: 310 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 369
Query: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHS---------------------------- 397
+ TPL A GH VA++LL+ GA N+ +
Sbjct: 370 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429
Query: 398 -NEFKESALT---LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
+ ES LT +A + GHL +V+ LL+ GA ++ T L A GH EVA+ L
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Query: 454 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHE 513
L + A+VN A ++PL AA GH + LL+E A+ G+TPL AAREGH
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549
Query: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570
E V LL + A+ T++ T L +A G + VA+ L++ A TPL
Sbjct: 550 ETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 608
Query: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
A +L++VK LL G + H+ G T L A + +VA LLQ G ES G
Sbjct: 609 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668
Query: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
TPL AA+ GH V L+SK AN N + T L L GH+ V ++L+ HG
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMV 727
Query: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
+ G T L A+ G+ +V +LL +
Sbjct: 728 DATTRMGYTPLHVASHYGNIKLVKFLLQH 756
Score = 206 bits (525), Expect = 2e-52
Identities = 176/553 (31%), Positives = 253/553 (45%), Gaps = 35/553 (6%)
Query: 213 DEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLC 272
DE L A A + Q L A E + V+ LL G + N TE+G + L
Sbjct: 124 DEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 182
Query: 273 LACSAGYYELAQVLL-----------AMHANVEDRGI-----------------KGDITP 304
+A G+ + L+ A+H + K TP
Sbjct: 183 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 242
Query: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
L AA+ ++ + +LLL A VN G T L A G V +V++LL+ GA IE
Sbjct: 243 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 302
Query: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
++ TPL A GHV ++ +LL++GA I + S + +A HL+ VR LL+
Sbjct: 303 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYD 361
Query: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484
A+ + T + T L A GH VA++LLD GA+ N A + +PL +A HV +
Sbjct: 362 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 421
Query: 485 LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
LL++ GAS++ V + G TPL A+ GH +V LL +GA+ N + ET L +A
Sbjct: 422 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARA 480
Query: 545 GFLEVADFLIKAGADIELGC---STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601
G EVA +L++ A + TPL AA+ GH +VK LL AN + T G T L
Sbjct: 481 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540
Query: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661
A GH + LL+ A ++ G TPL AA+ G V + L+ + A+ N
Sbjct: 541 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAG 599
Query: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPN 721
N T L +A +L +V+LLL G P +G T L AAK V LL Y
Sbjct: 600 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659
Query: 722 NLLSAPPPDVTQL 734
+ + VT L
Sbjct: 660 SANAESVQGVTPL 672
Score = 205 bits (522), Expect = 4e-52
Identities = 160/485 (32%), Positives = 241/485 (49%), Gaps = 11/485 (2%)
Query: 237 SLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 296
S A G+++ L G +N + G + L LA G+ ++ LL +E
Sbjct: 48 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 107
Query: 297 GIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
KG+ T L AA G ++V+ L+ + A+VNAQS G T L A +++VVK LLE+
Sbjct: 108 TKKGN-TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
Query: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416
GA+ E+G TPL A GH V L+ G + + AL +A
Sbjct: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRT 221
Query: 417 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 476
LL+ + + + T L A ++ VA+LLL+ GA VN + +PL +A+
Sbjct: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 281
Query: 477 GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQET 536
G+V + LL++RGA +E + TPL AAR GH + +LL GA I A+T+ +
Sbjct: 282 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-S 340
Query: 537 ALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHAT 593
+ +A G L+ L++ A DI L TPL AA GH + K LL GA ++
Sbjct: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 400
Query: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653
G T L AC+ H V ++LL+ GA ++ +E G TPL A+ GH+ V+ L+ +G
Sbjct: 401 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 460
Query: 654 ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
A+ N + + T L +A GH V + LL + A + KD T L AA+ GHT++V
Sbjct: 461 ASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 519
Query: 714 CYLLD 718
LL+
Sbjct: 520 KLLLE 524
Score = 199 bits (506), Expect = 3e-50
Identities = 146/412 (35%), Positives = 209/412 (50%), Gaps = 6/412 (1%)
Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
AC + V + LL G S++ TE G + L +A G+ + + LL A+ +K
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470
Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
+ TPL AA GH ++ K LL +KA VNA++ T L A G+ ++VK+LLE+ A+
Sbjct: 471 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529
Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
GHTPL A GHVE LLE A + + + L +A G + + L
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 588
Query: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 589 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648
Query: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
E+A L++ G S + +G TPL AA+EGH EMVALLL + AN N + T L L
Sbjct: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 707
Query: 541 ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
G + VAD LIK G ++ TPL A+ G+++LVK+LL A+V+A T G
Sbjct: 708 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 767
Query: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649
+ L A + GHTD+ +LL+ GA S G TPL A R G++ L
Sbjct: 768 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 193 bits (491), Expect = 2e-48
Identities = 224/842 (26%), Positives = 363/842 (43%), Gaps = 110/842 (13%)
Query: 369 TPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQE 428
T + A +G+++ A L NG INT N+ + L LA +GH++MV LL E
Sbjct: 47 TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 105
Query: 429 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 488
T + +TAL A + G EV R L++ GA VN + +PL +AA H+E+ L+E
Sbjct: 106 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165
Query: 489 RGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA---------NINAQTEETQETALT 539
GA+ ++G+TPL A ++GHE +VA L+ G +I A+ ++T+ A+
Sbjct: 166 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 225
Query: 540 L--------ACCGGF-----------LEVADFLIKAGADIEL---GCSTPLMEAAQEGHL 577
L GF L VA L+ GA + TPL A++ G++
Sbjct: 226 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 285
Query: 578 ELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 637
+V+ LL GA + T T L A NGH ++++LL GA ++ +++ G +P+ A
Sbjct: 286 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 345
Query: 638 ARAGHVCTVQFLISKGANVNRTTANNDH-TVLSLACAGGHLAVVELLLAHGADPTHRLKD 696
A+ H+ V+ L+ A ++ T DH T L +A GH V ++LL GA P R +
Sbjct: 346 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 403
Query: 697 GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVV 756
G T L A K H V+ LL ++ + +T L S + LP+V
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASF---------MGHLPIVK 454
Query: 757 PPQEPDKPP--ANVATTLPIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGK 814
+ P +NV P+ A A +V Y+ Q+ + +A+
Sbjct: 455 NLLQRGASPNVSNVKVETPLHMAAR----------AGHTEVAKYLL-QNKAKVNAKAKDD 503
Query: 815 LTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELN-KTREEQIQKKQKILE-ELQKV 872
T L + +L A+ + T L+ RE ++ +LE E +
Sbjct: 504 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563
Query: 873 ERELQLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQV 932
+ T + +Y +V+ + L++ + LTP+ V + D +L
Sbjct: 564 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL--- 620
Query: 933 DPVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGPLPPGSIANLTELQGV----IVGQP 988
+L + + A G+ P+ A + +A L G AN +QGV + Q
Sbjct: 621 --LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 678
Query: 989 VLGQAQLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAAS 1048
G A++ L +L++ G + G S + TP H +A
Sbjct: 679 --GHAEMVAL---LLSKQANGNL--------------------GNKSGL--TPLHLVA-- 709
Query: 1049 ISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGAS 1108
+ P +I M +DA T + T L +A G+ +LV+ LL+ A
Sbjct: 710 -QEGHVPVADVLIKHGVM--------VDATTRMGY-TPLHVASHYGNIKLVKFLLQHQAD 759
Query: 1109 IEHRDKKGFTPLILAATAGHVGVVEILLDNGAD-IEAQSERTKDTPLSLACSGGRQEVVE 1167
+ + K G++PL AA GH +V +LL NGA E S+ T TPL++A G V +
Sbjct: 760 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIAKRLGYISVTD 817
Query: 1168 LL 1169
+L
Sbjct: 818 VL 819
Score = 176 bits (446), Expect = 3e-43
Identities = 119/363 (32%), Positives = 191/363 (52%), Gaps = 45/363 (12%)
Query: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
T +TAL +A G +E+V+ L+ GA++ + +KGFTPL +AA H+ VV+ LL+N
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
Query: 1139 GADIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------E 1167
GA+ Q+ T+D TPL++A G + VV
Sbjct: 167 GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 223
Query: 1168 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1227
+LL N + + + +TPL +AA +N+ ++LLN GA +N + GI+PL +A+
Sbjct: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 281
Query: 1228 NGHTAAVKLLLDMGSDINAQIETNRNTALT---LACFQGRTEVVSLLLDRKANVEHRAKT 1284
G+ V+LLLD G AQIET LT A G + +LLD A ++ + K
Sbjct: 282 RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337
Query: 1285 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1344
GL+P+ AA G + + R+LL A+++ + T L +AA GH++ ++L+ +GA
Sbjct: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 395
Query: 1345 HIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRY 1404
+ R G TPL +A H+ V++LL++ GA +DA +TPL A GH+ +V+
Sbjct: 396 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 455
Query: 1405 LVK 1407
L++
Sbjct: 456 LLQ 458
Score = 172 bits (435), Expect = 5e-42
Identities = 124/333 (37%), Positives = 173/333 (51%), Gaps = 7/333 (2%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
IDA TES T L +A GH +V+ LL+RGAS + K TPL +AA AGH V +
Sbjct: 430 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 488
Query: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
LL N A + A++ + TPL A G +V+LLL AN + +TPL +AA G
Sbjct: 489 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 547
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
+V + LL E + +K G +PL +AA G +LLL+ + NA + N T
Sbjct: 548 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 604
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664
Query: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
V T L +AA +GH + LL+ + A+ ++ NK G TPL L A GH+ V +L++
Sbjct: 665 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722
Query: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
G VDA TPL A G++K+V++L++
Sbjct: 723 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755
Score = 168 bits (426), Expect = 6e-41
Identities = 124/362 (34%), Positives = 188/362 (51%), Gaps = 34/362 (9%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
+++AQ++ T L +A H E+V+ LLE GA+ + GFTPL +A GH VV
Sbjct: 136 NVNAQSQKGF-TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 194
Query: 1134 ILLDNGAD---------IEAQSERTKD-------------------TPLSLACSGGRQEV 1165
L++ G I A+++ T+ TPL +A V
Sbjct: 195 HLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNV 254
Query: 1166 VELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA 1225
+LLL RGA+ + TPL +A+ G V ++++LL+ GA+I ++T +L +PL A
Sbjct: 255 AQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCA 312
Query: 1226 AMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1285
A NGH ++LLD G+ I A+ + N + + +A + V LLL A ++
Sbjct: 313 ARNGHVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 371
Query: 1286 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH 1345
LTPL AA G+ V +VLLDKGA N+ + T L IA K H + ELL+ GA
Sbjct: 372 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGAS 429
Query: 1346 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYL 1405
ID + G TPL +A+ GHL +V+ L+Q GA + ++ + TPL A R GH +V +YL
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Query: 1406 VK 1407
++
Sbjct: 490 LQ 491
Score = 164 bits (414), Expect = 1e-39
Identities = 119/335 (35%), Positives = 171/335 (51%), Gaps = 15/335 (4%)
Query: 1075 IDAQT-ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
+D T N L LA GH ++V LL + +E KKG T L +AA AG VV
Sbjct: 69 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 128
Query: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
L++ GA++ AQS++ TPL +A EVV+ LL GAN+ +TPL++A
Sbjct: 129 ELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 187
Query: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG--HTAAVKLLLDMGSDINAQIETN 1251
G+ N++ L+N G T K+ + L +AA N TAAV L D D+ +
Sbjct: 188 GHENVVAHLINYG------TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV---LSKT 238
Query: 1252 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311
T L +A V LLL+R A+V + G+TPL A+ G + R+LLD+GA +
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 298
Query: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
T L AA GH + E+L+ GA I + K G +P+ +AA G HLD V+L
Sbjct: 299 ETK--TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356
Query: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
L+Q A++D +TPL A GH +V + L+
Sbjct: 357 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 391
Score = 129 bits (323), Expect = 5e-29
Identities = 103/346 (29%), Positives = 161/346 (46%), Gaps = 35/346 (10%)
Query: 426 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 485
D++ K D T+ + A G+++ A L +G +N + + L LA+ GHV++
Sbjct: 38 DRKKKADAA-TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 96
Query: 486 LIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGG 545
L+ + LE +G T L AA G +E+V L+ GAN+NAQ+++ T L +A
Sbjct: 97 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQEN 155
Query: 546 FLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGA-------------- 588
LEV FL++ GA+ + TPL A Q+GH +V +L+ G
Sbjct: 156 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 215
Query: 589 ---------------NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 633
N + TG T L A + +VA +LL GA + + G TP
Sbjct: 216 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITP 275
Query: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693
L A+R G+V V+ L+ +GA + T ++ T L A GH+ + E+LL HGA +
Sbjct: 276 LHIASRRGNVIMVRLLLDRGAQI-ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 334
Query: 694 LKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSH 739
K+G + + AA+G H V LL Y + +T L +H
Sbjct: 335 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 380
Score = 62.8 bits (151), Expect = 4e-09
Identities = 39/121 (32%), Positives = 64/121 (52%), Gaps = 2/121 (1%)
Query: 1287 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1346
T + AA G + L G D+N + L +A+ +GH K L+ + +
Sbjct: 47 TSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMVVELLHKEIIL 104
Query: 1347 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
+ KKGNT L +AA G +VV+ LV GA+V+A + TPL A ++ H++VV++L+
Sbjct: 105 ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 164
Query: 1407 K 1407
+
Sbjct: 165 E 165
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 228 bits (580), Expect = 8e-59
Identities = 202/643 (31%), Positives = 298/643 (46%), Gaps = 65/643 (10%)
Query: 209 SCALDEAAAALTRMRAESTAN----------------AGQSDNRSLAEACSEGDVNAVRK 252
S EA AA + +RA + N Q+ L A EG V V +
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 253 LLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
LL + + T++G + L +A AG E+ + L+ ANV + KG TPL AA
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQEN 122
Query: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVV---------------------- 350
H+++VK LL + A+ N + G T L A G+ +VV
Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182
Query: 351 -------KVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKE 402
VLL++ + + ++ G TPL A ++ VA+LLL GA +N T N
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI-- 240
Query: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
+ L +A +G++ MVR LL+ GA E KT + T L A +GHV ++ +LLD GA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
+ SP+ +AA G H++ LL++ A ++++ + TPL AA GH + +LL +
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLEL 579
GA N++ T L +AC + V + L+K GA I+ TPL A+ GHL +
Sbjct: 361 GAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
VK LL GA+ + + +T L A GHT+VA LLQ A + +++ +TPL AAR
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
GH V+ L+ AN N T HT L +A GH+ V LL A K G T
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538
Query: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-P 758
L AAK G V LL+ + +A +T L H N + + +++P
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRG 592
Query: 759 QEPDKPPANVATTLPIRNKAASKQKSSSHL----PANSQDVQG 797
P P N T L I K + + S L AN++ VQG
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Score = 224 bits (571), Expect = 9e-58
Identities = 167/513 (32%), Positives = 257/513 (50%), Gaps = 16/513 (3%)
Query: 208 VSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
V LD A T+ + E T L A G V LL G + T+ G
Sbjct: 255 VRLLLDRGAQIETKTKDELTP---------LHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 268 ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADV 327
S + +A + + ++LL A ++D + +TPL AA+ GH ++ K+LL A
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 328 NAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLL 387
N+++ G T L AC +V V+++LL++GASI+ E+G TPL A GH+ + + LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 388 ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447
+ GA N SN E+ L +A GH E+ ++LL+ A K + T L A GH
Sbjct: 425 QRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 448 EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507
+ +LLL++ A N+ + +PL +AA GHVE L+E+ AS + +G+TPL A
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 508 AREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC--- 564
A+ G + LLL + A+ NA + T L +A L++ L+ G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
TPL AA++ +E+ + LL G + +A + G T L A + GH ++ +LL A+
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
++ G TPL A+ GHV LI G V+ TT +T L +A G++ +V+ LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG-YTPLHVASHYGNIKLVKFLL 721
Query: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
H AD + K G + L +AA+ GHT +V LL
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Score = 221 bits (564), Expect = 6e-57
Identities = 166/474 (35%), Positives = 242/474 (51%), Gaps = 8/474 (1%)
Query: 243 SEGD-VNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
++GD ++ VR LL +++ T + + L +A G++ +A+VLL A R + G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
Query: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
TPL A HV++++LLL A ++A + +G T L A G++ +VK LL+ GAS
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
N TPL A AGH EVA+ LL+N A +N + + ++ L A GH MV+ LL
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
Query: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
Query: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
+A LL+ER A G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
Query: 542 CCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
+EVA L++ G TPL AAQEGH E+V LL+ AN + +G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
T L + GH VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
T ++ L A GH +V LLL +GA P DG+T L A + G+ SV
Sbjct: 730 KT-KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Score = 220 bits (560), Expect = 2e-56
Identities = 169/509 (33%), Positives = 248/509 (48%), Gaps = 38/509 (7%)
Query: 246 DVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPL 305
++N + LL G SVN + G + L +A G + ++LL A +E + K ++TPL
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK-TKDELTPL 276
Query: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
AA GHV+I ++LL H A + A++ G + + A G ++D V++LL+ A I+D
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 336
Query: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHS---------------------------- 397
+ TPL A GH VA++LL+ GA N+ +
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 398 -NEFKESALT---LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
+ ES LT +A + GHL +V+ LL+ GA ++ T L A GH EVA+ L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 454 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHE 513
L + A+VN A ++PL AA GH + LL+E A+ G+TPL AAREGH
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570
E V LL + A+ T++ T L +A G + VA+ L++ A TPL
Sbjct: 517 ETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Query: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
A +L++VK LL G + H+ G T L A + +VA LLQ G ES G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
TPL AA+ GH V L+SK AN N + T L L GH+ V ++L+ HG
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
+ G T L A+ G+ +V +LL +
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Score = 206 bits (525), Expect = 2e-52
Identities = 176/553 (31%), Positives = 253/553 (45%), Gaps = 35/553 (6%)
Query: 213 DEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLC 272
DE L A A + Q L A E + V+ LL G + N TE+G + L
Sbjct: 91 DEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 273 LACSAGYYELAQVLL-----------AMHANVEDRGI-----------------KGDITP 304
+A G+ + L+ A+H + K TP
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209
Query: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
L AA+ ++ + +LLL A VN G T L A G V +V++LL+ GA IE
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
Query: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
++ TPL A GHV ++ +LL++GA I + S + +A HL+ VR LL+
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484
A+ + T + T L A GH VA++LLD GA+ N A + +PL +A HV +
Sbjct: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 388
Query: 485 LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
LL++ GAS++ V + G TPL A+ GH +V LL +GA+ N + ET L +A
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARA 447
Query: 545 GFLEVADFLIKAGADIELGC---STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601
G EVA +L++ A + TPL AA+ GH +VK LL AN + T G T L
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
Query: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661
A GH + LL+ A ++ G TPL AA+ G V + L+ + A+ N
Sbjct: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAG 566
Query: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPN 721
N T L +A +L +V+LLL G P +G T L AAK V LL Y
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 722 NLLSAPPPDVTQL 734
+ + VT L
Sbjct: 627 SANAESVQGVTPL 639
Score = 199 bits (506), Expect = 3e-50
Identities = 146/412 (35%), Positives = 209/412 (50%), Gaps = 6/412 (1%)
Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
AC + V + LL G S++ TE G + L +A G+ + + LL A+ +K
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
+ TPL AA GH ++ K LL +KA VNA++ T L A G+ ++VK+LLE+ A+
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
GHTPL A GHVE LLE A + + + L +A G + + L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
Query: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
E+A L++ G S + +G TPL AA+EGH EMVALLL + AN N + T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
Query: 541 ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
G + VAD LIK G ++ TPL A+ G+++LVK+LL A+V+A T G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649
+ L A + GHTD+ +LL+ GA S G TPL A R G++ L
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 176 bits (446), Expect = 3e-43
Identities = 119/363 (32%), Positives = 191/363 (52%), Gaps = 45/363 (12%)
Query: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
T +TAL +A G +E+V+ L+ GA++ + +KGFTPL +AA H+ VV+ LL+N
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 1139 GADIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------E 1167
GA+ Q+ T+D TPL++A G + VV
Sbjct: 134 GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 1168 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1227
+LL N + + + +TPL +AA +N+ ++LLN GA +N + GI+PL +A+
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 248
Query: 1228 NGHTAAVKLLLDMGSDINAQIETNRNTALT---LACFQGRTEVVSLLLDRKANVEHRAKT 1284
G+ V+LLLD G AQIET LT A G + +LLD A ++ + K
Sbjct: 249 RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 1285 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1344
GL+P+ AA G + + R+LL A+++ + T L +AA GH++ ++L+ +GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 1345 HIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRY 1404
+ R G TPL +A H+ V++LL++ GA +DA +TPL A GH+ +V+
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 1405 LVK 1407
L++
Sbjct: 423 LLQ 425
Score = 172 bits (435), Expect = 5e-42
Identities = 124/333 (37%), Positives = 173/333 (51%), Gaps = 7/333 (2%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
IDA TES T L +A GH +V+ LL+RGAS + K TPL +AA AGH V +
Sbjct: 397 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
LL N A + A++ + TPL A G +V+LLL AN + +TPL +AA G
Sbjct: 456 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
+V + LL E + +K G +PL +AA G +LLL+ + NA + N T
Sbjct: 515 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
V T L +AA +GH + LL+ + A+ ++ NK G TPL L A GH+ V +L++
Sbjct: 632 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
G VDA TPL A G++K+V++L++
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Score = 168 bits (426), Expect = 6e-41
Identities = 124/362 (34%), Positives = 188/362 (51%), Gaps = 34/362 (9%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
+++AQ++ T L +A H E+V+ LLE GA+ + GFTPL +A GH VV
Sbjct: 103 NVNAQSQKGF-TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 161
Query: 1134 ILLDNGAD---------IEAQSERTKD-------------------TPLSLACSGGRQEV 1165
L++ G I A+++ T+ TPL +A V
Sbjct: 162 HLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNV 221
Query: 1166 VELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA 1225
+LLL RGA+ + TPL +A+ G V ++++LL+ GA+I ++T +L +PL A
Sbjct: 222 AQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCA 279
Query: 1226 AMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1285
A NGH ++LLD G+ I A+ + N + + +A + V LLL A ++
Sbjct: 280 ARNGHVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 1286 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH 1345
LTPL AA G+ V +VLLDKGA N+ + T L IA K H + ELL+ GA
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGAS 396
Query: 1346 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYL 1405
ID + G TPL +A+ GHL +V+ L+Q GA + ++ + TPL A R GH +V +YL
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 1406 VK 1407
++
Sbjct: 457 LQ 458
Score = 164 bits (414), Expect = 1e-39
Identities = 119/335 (35%), Positives = 171/335 (51%), Gaps = 15/335 (4%)
Query: 1075 IDAQT-ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
+D T N L LA GH ++V LL + +E KKG T L +AA AG VV
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
L++ GA++ AQS++ TPL +A EVV+ LL GAN+ +TPL++A
Sbjct: 96 ELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
Query: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG--HTAAVKLLLDMGSDINAQIETN 1251
G+ N++ L+N G T K+ + L +AA N TAAV L D D+ +
Sbjct: 155 GHENVVAHLINYG------TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV---LSKT 205
Query: 1252 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311
T L +A V LLL+R A+V + G+TPL A+ G + R+LLD+GA +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
T L AA GH + E+L+ GA I + K G +P+ +AA G HLD V+L
Sbjct: 266 ETK--TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
L+Q A++D +TPL A GH +V + L+
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Score = 63.9 bits (154), Expect = 2e-09
Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 2/131 (1%)
Query: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336
+V R T + AA G + L G D+N + L +A+ +GH K
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
Query: 1337 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1396
L+ + ++ KKGNT L +AA G +VV+ LV GA+V+A + TPL A ++
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 1397 GHVKVVRYLVK 1407
H++VV++L++
Sbjct: 122 NHLEVVKFLLE 132
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 228 bits (580), Expect = 8e-59
Identities = 202/643 (31%), Positives = 298/643 (46%), Gaps = 65/643 (10%)
Query: 209 SCALDEAAAALTRMRAESTAN----------------AGQSDNRSLAEACSEGDVNAVRK 252
S EA AA + +RA + N Q+ L A EG V V +
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 253 LLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
LL + + T++G + L +A AG E+ + L+ ANV + KG TPL AA
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQEN 122
Query: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVV---------------------- 350
H+++VK LL + A+ N + G T L A G+ +VV
Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182
Query: 351 -------KVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKE 402
VLL++ + + ++ G TPL A ++ VA+LLL GA +N T N
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI-- 240
Query: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
+ L +A +G++ MVR LL+ GA E KT + T L A +GHV ++ +LLD GA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
+ SP+ +AA G H++ LL++ A ++++ + TPL AA GH + +LL +
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLEL 579
GA N++ T L +AC + V + L+K GA I+ TPL A+ GHL +
Sbjct: 361 GAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
VK LL GA+ + + +T L A GHT+VA LLQ A + +++ +TPL AAR
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
GH V+ L+ AN N T HT L +A GH+ V LL A K G T
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538
Query: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-P 758
L AAK G V LL+ + +A +T L H N + + +++P
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRG 592
Query: 759 QEPDKPPANVATTLPIRNKAASKQKSSSHL----PANSQDVQG 797
P P N T L I K + + S L AN++ VQG
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Score = 224 bits (571), Expect = 9e-58
Identities = 167/513 (32%), Positives = 257/513 (50%), Gaps = 16/513 (3%)
Query: 208 VSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
V LD A T+ + E T L A G V LL G + T+ G
Sbjct: 255 VRLLLDRGAQIETKTKDELTP---------LHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 268 ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADV 327
S + +A + + ++LL A ++D + +TPL AA+ GH ++ K+LL A
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 328 NAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLL 387
N+++ G T L AC +V V+++LL++GASI+ E+G TPL A GH+ + + LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 388 ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447
+ GA N SN E+ L +A GH E+ ++LL+ A K + T L A GH
Sbjct: 425 QRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 448 EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507
+ +LLL++ A N+ + +PL +AA GHVE L+E+ AS + +G+TPL A
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 508 AREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC--- 564
A+ G + LLL + A+ NA + T L +A L++ L+ G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
TPL AA++ +E+ + LL G + +A + G T L A + GH ++ +LL A+
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
++ G TPL A+ GHV LI G V+ TT +T L +A G++ +V+ LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG-YTPLHVASHYGNIKLVKFLL 721
Query: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
H AD + K G + L +AA+ GHT +V LL
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Score = 221 bits (564), Expect = 6e-57
Identities = 166/474 (35%), Positives = 242/474 (51%), Gaps = 8/474 (1%)
Query: 243 SEGD-VNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
++GD ++ VR LL +++ T + + L +A G++ +A+VLL A R + G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
Query: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
TPL A HV++++LLL A ++A + +G T L A G++ +VK LL+ GAS
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
N TPL A AGH EVA+ LL+N A +N + + ++ L A GH MV+ LL
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
Query: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
Query: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
+A LL+ER A G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
Query: 542 CCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
+EVA L++ G TPL AAQEGH E+V LL+ AN + +G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
T L + GH VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
T ++ L A GH +V LLL +GA P DG+T L A + G+ SV
Sbjct: 730 KT-KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Score = 220 bits (560), Expect = 2e-56
Identities = 169/509 (33%), Positives = 248/509 (48%), Gaps = 38/509 (7%)
Query: 246 DVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPL 305
++N + LL G SVN + G + L +A G + ++LL A +E + K ++TPL
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK-TKDELTPL 276
Query: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
AA GHV+I ++LL H A + A++ G + + A G ++D V++LL+ A I+D
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 336
Query: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHS---------------------------- 397
+ TPL A GH VA++LL+ GA N+ +
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 398 -NEFKESALT---LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
+ ES LT +A + GHL +V+ LL+ GA ++ T L A GH EVA+ L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 454 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHE 513
L + A+VN A ++PL AA GH + LL+E A+ G+TPL AAREGH
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570
E V LL + A+ T++ T L +A G + VA+ L++ A TPL
Sbjct: 517 ETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Query: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
A +L++VK LL G + H+ G T L A + +VA LLQ G ES G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
TPL AA+ GH V L+SK AN N + T L L GH+ V ++L+ HG
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
+ G T L A+ G+ +V +LL +
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Score = 206 bits (525), Expect = 2e-52
Identities = 176/553 (31%), Positives = 253/553 (45%), Gaps = 35/553 (6%)
Query: 213 DEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLC 272
DE L A A + Q L A E + V+ LL G + N TE+G + L
Sbjct: 91 DEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 273 LACSAGYYELAQVLL-----------AMHANVEDRGI-----------------KGDITP 304
+A G+ + L+ A+H + K TP
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209
Query: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
L AA+ ++ + +LLL A VN G T L A G V +V++LL+ GA IE
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
Query: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
++ TPL A GHV ++ +LL++GA I + S + +A HL+ VR LL+
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484
A+ + T + T L A GH VA++LLD GA+ N A + +PL +A HV +
Sbjct: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 388
Query: 485 LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
LL++ GAS++ V + G TPL A+ GH +V LL +GA+ N + ET L +A
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARA 447
Query: 545 GFLEVADFLIKAGADIELGC---STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601
G EVA +L++ A + TPL AA+ GH +VK LL AN + T G T L
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
Query: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661
A GH + LL+ A ++ G TPL AA+ G V + L+ + A+ N
Sbjct: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAG 566
Query: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPN 721
N T L +A +L +V+LLL G P +G T L AAK V LL Y
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 722 NLLSAPPPDVTQL 734
+ + VT L
Sbjct: 627 SANAESVQGVTPL 639
Score = 199 bits (506), Expect = 3e-50
Identities = 146/412 (35%), Positives = 209/412 (50%), Gaps = 6/412 (1%)
Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
AC + V + LL G S++ TE G + L +A G+ + + LL A+ +K
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
+ TPL AA GH ++ K LL +KA VNA++ T L A G+ ++VK+LLE+ A+
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
GHTPL A GHVE LLE A + + + L +A G + + L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
Query: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
E+A L++ G S + +G TPL AA+EGH EMVALLL + AN N + T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
Query: 541 ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
G + VAD LIK G ++ TPL A+ G+++LVK+LL A+V+A T G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649
+ L A + GHTD+ +LL+ GA S G TPL A R G++ L
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 176 bits (446), Expect = 3e-43
Identities = 119/363 (32%), Positives = 191/363 (52%), Gaps = 45/363 (12%)
Query: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
T +TAL +A G +E+V+ L+ GA++ + +KGFTPL +AA H+ VV+ LL+N
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 1139 GADIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------E 1167
GA+ Q+ T+D TPL++A G + VV
Sbjct: 134 GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 1168 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1227
+LL N + + + +TPL +AA +N+ ++LLN GA +N + GI+PL +A+
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 248
Query: 1228 NGHTAAVKLLLDMGSDINAQIETNRNTALT---LACFQGRTEVVSLLLDRKANVEHRAKT 1284
G+ V+LLLD G AQIET LT A G + +LLD A ++ + K
Sbjct: 249 RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 1285 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1344
GL+P+ AA G + + R+LL A+++ + T L +AA GH++ ++L+ +GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 1345 HIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRY 1404
+ R G TPL +A H+ V++LL++ GA +DA +TPL A GH+ +V+
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 1405 LVK 1407
L++
Sbjct: 423 LLQ 425
Score = 172 bits (435), Expect = 5e-42
Identities = 124/333 (37%), Positives = 173/333 (51%), Gaps = 7/333 (2%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
IDA TES T L +A GH +V+ LL+RGAS + K TPL +AA AGH V +
Sbjct: 397 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
LL N A + A++ + TPL A G +V+LLL AN + +TPL +AA G
Sbjct: 456 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
+V + LL E + +K G +PL +AA G +LLL+ + NA + N T
Sbjct: 515 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
V T L +AA +GH + LL+ + A+ ++ NK G TPL L A GH+ V +L++
Sbjct: 632 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
G VDA TPL A G++K+V++L++
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Score = 168 bits (426), Expect = 6e-41
Identities = 124/362 (34%), Positives = 188/362 (51%), Gaps = 34/362 (9%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
+++AQ++ T L +A H E+V+ LLE GA+ + GFTPL +A GH VV
Sbjct: 103 NVNAQSQKGF-TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 161
Query: 1134 ILLDNGAD---------IEAQSERTKD-------------------TPLSLACSGGRQEV 1165
L++ G I A+++ T+ TPL +A V
Sbjct: 162 HLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNV 221
Query: 1166 VELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA 1225
+LLL RGA+ + TPL +A+ G V ++++LL+ GA+I ++T +L +PL A
Sbjct: 222 AQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCA 279
Query: 1226 AMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1285
A NGH ++LLD G+ I A+ + N + + +A + V LLL A ++
Sbjct: 280 ARNGHVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 1286 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH 1345
LTPL AA G+ V +VLLDKGA N+ + T L IA K H + ELL+ GA
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGAS 396
Query: 1346 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYL 1405
ID + G TPL +A+ GHL +V+ L+Q GA + ++ + TPL A R GH +V +YL
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 1406 VK 1407
++
Sbjct: 457 LQ 458
Score = 164 bits (414), Expect = 1e-39
Identities = 119/335 (35%), Positives = 171/335 (51%), Gaps = 15/335 (4%)
Query: 1075 IDAQT-ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
+D T N L LA GH ++V LL + +E KKG T L +AA AG VV
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
L++ GA++ AQS++ TPL +A EVV+ LL GAN+ +TPL++A
Sbjct: 96 ELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
Query: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG--HTAAVKLLLDMGSDINAQIETN 1251
G+ N++ L+N G T K+ + L +AA N TAAV L D D+ +
Sbjct: 155 GHENVVAHLINYG------TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV---LSKT 205
Query: 1252 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311
T L +A V LLL+R A+V + G+TPL A+ G + R+LLD+GA +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
T L AA GH + E+L+ GA I + K G +P+ +AA G HLD V+L
Sbjct: 266 ETK--TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
L+Q A++D +TPL A GH +V + L+
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Score = 63.9 bits (154), Expect = 2e-09
Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 2/131 (1%)
Query: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336
+V R T + AA G + L G D+N + L +A+ +GH K
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
Query: 1337 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1396
L+ + ++ KKGNT L +AA G +VV+ LV GA+V+A + TPL A ++
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 1397 GHVKVVRYLVK 1407
H++VV++L++
Sbjct: 122 NHLEVVKFLLE 132
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 228 bits (580), Expect = 8e-59
Identities = 202/643 (31%), Positives = 298/643 (46%), Gaps = 65/643 (10%)
Query: 209 SCALDEAAAALTRMRAESTAN----------------AGQSDNRSLAEACSEGDVNAVRK 252
S EA AA + +RA + N Q+ L A EG V V +
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 253 LLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
LL + + T++G + L +A AG E+ + L+ ANV + KG TPL AA
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQEN 122
Query: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVV---------------------- 350
H+++VK LL + A+ N + G T L A G+ +VV
Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182
Query: 351 -------KVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKE 402
VLL++ + + ++ G TPL A ++ VA+LLL GA +N T N
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI-- 240
Query: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
+ L +A +G++ MVR LL+ GA E KT + T L A +GHV ++ +LLD GA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
+ SP+ +AA G H++ LL++ A ++++ + TPL AA GH + +LL +
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLEL 579
GA N++ T L +AC + V + L+K GA I+ TPL A+ GHL +
Sbjct: 361 GAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
VK LL GA+ + + +T L A GHT+VA LLQ A + +++ +TPL AAR
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
GH V+ L+ AN N T HT L +A GH+ V LL A K G T
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538
Query: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-P 758
L AAK G V LL+ + +A +T L H N + + +++P
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRG 592
Query: 759 QEPDKPPANVATTLPIRNKAASKQKSSSHL----PANSQDVQG 797
P P N T L I K + + S L AN++ VQG
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Score = 224 bits (571), Expect = 9e-58
Identities = 167/513 (32%), Positives = 257/513 (50%), Gaps = 16/513 (3%)
Query: 208 VSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
V LD A T+ + E T L A G V LL G + T+ G
Sbjct: 255 VRLLLDRGAQIETKTKDELTP---------LHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 268 ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADV 327
S + +A + + ++LL A ++D + +TPL AA+ GH ++ K+LL A
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 328 NAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLL 387
N+++ G T L AC +V V+++LL++GASI+ E+G TPL A GH+ + + LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 388 ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447
+ GA N SN E+ L +A GH E+ ++LL+ A K + T L A GH
Sbjct: 425 QRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 448 EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507
+ +LLL++ A N+ + +PL +AA GHVE L+E+ AS + +G+TPL A
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 508 AREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC--- 564
A+ G + LLL + A+ NA + T L +A L++ L+ G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
TPL AA++ +E+ + LL G + +A + G T L A + GH ++ +LL A+
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
++ G TPL A+ GHV LI G V+ TT +T L +A G++ +V+ LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG-YTPLHVASHYGNIKLVKFLL 721
Query: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
H AD + K G + L +AA+ GHT +V LL
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Score = 221 bits (564), Expect = 6e-57
Identities = 166/474 (35%), Positives = 242/474 (51%), Gaps = 8/474 (1%)
Query: 243 SEGD-VNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
++GD ++ VR LL +++ T + + L +A G++ +A+VLL A R + G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
Query: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
TPL A HV++++LLL A ++A + +G T L A G++ +VK LL+ GAS
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
N TPL A AGH EVA+ LL+N A +N + + ++ L A GH MV+ LL
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
Query: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
Query: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
+A LL+ER A G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
Query: 542 CCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
+EVA L++ G TPL AAQEGH E+V LL+ AN + +G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
T L + GH VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
T ++ L A GH +V LLL +GA P DG+T L A + G+ SV
Sbjct: 730 KT-KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Score = 220 bits (560), Expect = 2e-56
Identities = 169/509 (33%), Positives = 248/509 (48%), Gaps = 38/509 (7%)
Query: 246 DVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPL 305
++N + LL G SVN + G + L +A G + ++LL A +E + K ++TPL
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK-TKDELTPL 276
Query: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
AA GHV+I ++LL H A + A++ G + + A G ++D V++LL+ A I+D
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 336
Query: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHS---------------------------- 397
+ TPL A GH VA++LL+ GA N+ +
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 398 -NEFKESALT---LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
+ ES LT +A + GHL +V+ LL+ GA ++ T L A GH EVA+ L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 454 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHE 513
L + A+VN A ++PL AA GH + LL+E A+ G+TPL AAREGH
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570
E V LL + A+ T++ T L +A G + VA+ L++ A TPL
Sbjct: 517 ETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Query: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
A +L++VK LL G + H+ G T L A + +VA LLQ G ES G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
TPL AA+ GH V L+SK AN N + T L L GH+ V ++L+ HG
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
+ G T L A+ G+ +V +LL +
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Score = 206 bits (525), Expect = 2e-52
Identities = 176/553 (31%), Positives = 253/553 (45%), Gaps = 35/553 (6%)
Query: 213 DEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLC 272
DE L A A + Q L A E + V+ LL G + N TE+G + L
Sbjct: 91 DEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 273 LACSAGYYELAQVLL-----------AMHANVEDRGI-----------------KGDITP 304
+A G+ + L+ A+H + K TP
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209
Query: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
L AA+ ++ + +LLL A VN G T L A G V +V++LL+ GA IE
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
Query: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
++ TPL A GHV ++ +LL++GA I + S + +A HL+ VR LL+
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484
A+ + T + T L A GH VA++LLD GA+ N A + +PL +A HV +
Sbjct: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 388
Query: 485 LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
LL++ GAS++ V + G TPL A+ GH +V LL +GA+ N + ET L +A
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARA 447
Query: 545 GFLEVADFLIKAGADIELGC---STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601
G EVA +L++ A + TPL AA+ GH +VK LL AN + T G T L
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
Query: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661
A GH + LL+ A ++ G TPL AA+ G V + L+ + A+ N
Sbjct: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAG 566
Query: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPN 721
N T L +A +L +V+LLL G P +G T L AAK V LL Y
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 722 NLLSAPPPDVTQL 734
+ + VT L
Sbjct: 627 SANAESVQGVTPL 639
Score = 199 bits (506), Expect = 3e-50
Identities = 146/412 (35%), Positives = 209/412 (50%), Gaps = 6/412 (1%)
Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
AC + V + LL G S++ TE G + L +A G+ + + LL A+ +K
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
+ TPL AA GH ++ K LL +KA VNA++ T L A G+ ++VK+LLE+ A+
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
GHTPL A GHVE LLE A + + + L +A G + + L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
Query: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
E+A L++ G S + +G TPL AA+EGH EMVALLL + AN N + T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
Query: 541 ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
G + VAD LIK G ++ TPL A+ G+++LVK+LL A+V+A T G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649
+ L A + GHTD+ +LL+ GA S G TPL A R G++ L
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 176 bits (446), Expect = 3e-43
Identities = 119/363 (32%), Positives = 191/363 (52%), Gaps = 45/363 (12%)
Query: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
T +TAL +A G +E+V+ L+ GA++ + +KGFTPL +AA H+ VV+ LL+N
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 1139 GADIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------E 1167
GA+ Q+ T+D TPL++A G + VV
Sbjct: 134 GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 1168 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1227
+LL N + + + +TPL +AA +N+ ++LLN GA +N + GI+PL +A+
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 248
Query: 1228 NGHTAAVKLLLDMGSDINAQIETNRNTALT---LACFQGRTEVVSLLLDRKANVEHRAKT 1284
G+ V+LLLD G AQIET LT A G + +LLD A ++ + K
Sbjct: 249 RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 1285 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1344
GL+P+ AA G + + R+LL A+++ + T L +AA GH++ ++L+ +GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 1345 HIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRY 1404
+ R G TPL +A H+ V++LL++ GA +DA +TPL A GH+ +V+
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 1405 LVK 1407
L++
Sbjct: 423 LLQ 425
Score = 172 bits (435), Expect = 5e-42
Identities = 124/333 (37%), Positives = 173/333 (51%), Gaps = 7/333 (2%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
IDA TES T L +A GH +V+ LL+RGAS + K TPL +AA AGH V +
Sbjct: 397 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
LL N A + A++ + TPL A G +V+LLL AN + +TPL +AA G
Sbjct: 456 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
+V + LL E + +K G +PL +AA G +LLL+ + NA + N T
Sbjct: 515 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
V T L +AA +GH + LL+ + A+ ++ NK G TPL L A GH+ V +L++
Sbjct: 632 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
G VDA TPL A G++K+V++L++
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Score = 168 bits (426), Expect = 6e-41
Identities = 124/362 (34%), Positives = 188/362 (51%), Gaps = 34/362 (9%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
+++AQ++ T L +A H E+V+ LLE GA+ + GFTPL +A GH VV
Sbjct: 103 NVNAQSQKGF-TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 161
Query: 1134 ILLDNGAD---------IEAQSERTKD-------------------TPLSLACSGGRQEV 1165
L++ G I A+++ T+ TPL +A V
Sbjct: 162 HLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNV 221
Query: 1166 VELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA 1225
+LLL RGA+ + TPL +A+ G V ++++LL+ GA+I ++T +L +PL A
Sbjct: 222 AQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCA 279
Query: 1226 AMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1285
A NGH ++LLD G+ I A+ + N + + +A + V LLL A ++
Sbjct: 280 ARNGHVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 1286 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH 1345
LTPL AA G+ V +VLLDKGA N+ + T L IA K H + ELL+ GA
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGAS 396
Query: 1346 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYL 1405
ID + G TPL +A+ GHL +V+ L+Q GA + ++ + TPL A R GH +V +YL
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 1406 VK 1407
++
Sbjct: 457 LQ 458
Score = 164 bits (414), Expect = 1e-39
Identities = 119/335 (35%), Positives = 171/335 (51%), Gaps = 15/335 (4%)
Query: 1075 IDAQT-ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
+D T N L LA GH ++V LL + +E KKG T L +AA AG VV
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
L++ GA++ AQS++ TPL +A EVV+ LL GAN+ +TPL++A
Sbjct: 96 ELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
Query: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG--HTAAVKLLLDMGSDINAQIETN 1251
G+ N++ L+N G T K+ + L +AA N TAAV L D D+ +
Sbjct: 155 GHENVVAHLINYG------TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV---LSKT 205
Query: 1252 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311
T L +A V LLL+R A+V + G+TPL A+ G + R+LLD+GA +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
T L AA GH + E+L+ GA I + K G +P+ +AA G HLD V+L
Sbjct: 266 ETK--TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
L+Q A++D +TPL A GH +V + L+
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Score = 63.9 bits (154), Expect = 2e-09
Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 2/131 (1%)
Query: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336
+V R T + AA G + L G D+N + L +A+ +GH K
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
Query: 1337 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1396
L+ + ++ KKGNT L +AA G +VV+ LV GA+V+A + TPL A ++
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 1397 GHVKVVRYLVK 1407
H++VV++L++
Sbjct: 122 NHLEVVKFLLE 132
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 228 bits (580), Expect = 8e-59
Identities = 202/643 (31%), Positives = 298/643 (46%), Gaps = 65/643 (10%)
Query: 209 SCALDEAAAALTRMRAESTAN----------------AGQSDNRSLAEACSEGDVNAVRK 252
S EA AA + +RA + N Q+ L A EG V V +
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 253 LLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
LL + + T++G + L +A AG E+ + L+ ANV + KG TPL AA
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQEN 122
Query: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVV---------------------- 350
H+++VK LL + A+ N + G T L A G+ +VV
Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182
Query: 351 -------KVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKE 402
VLL++ + + ++ G TPL A ++ VA+LLL GA +N T N
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI-- 240
Query: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
+ L +A +G++ MVR LL+ GA E KT + T L A +GHV ++ +LLD GA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
+ SP+ +AA G H++ LL++ A ++++ + TPL AA GH + +LL +
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLEL 579
GA N++ T L +AC + V + L+K GA I+ TPL A+ GHL +
Sbjct: 361 GAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
VK LL GA+ + + +T L A GHT+VA LLQ A + +++ +TPL AAR
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
GH V+ L+ AN N T HT L +A GH+ V LL A K G T
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538
Query: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-P 758
L AAK G V LL+ + +A +T L H N + + +++P
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRG 592
Query: 759 QEPDKPPANVATTLPIRNKAASKQKSSSHL----PANSQDVQG 797
P P N T L I K + + S L AN++ VQG
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Score = 224 bits (571), Expect = 9e-58
Identities = 167/513 (32%), Positives = 257/513 (50%), Gaps = 16/513 (3%)
Query: 208 VSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
V LD A T+ + E T L A G V LL G + T+ G
Sbjct: 255 VRLLLDRGAQIETKTKDELTP---------LHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 268 ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADV 327
S + +A + + ++LL A ++D + +TPL AA+ GH ++ K+LL A
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 328 NAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLL 387
N+++ G T L AC +V V+++LL++GASI+ E+G TPL A GH+ + + LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 388 ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447
+ GA N SN E+ L +A GH E+ ++LL+ A K + T L A GH
Sbjct: 425 QRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 448 EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507
+ +LLL++ A N+ + +PL +AA GHVE L+E+ AS + +G+TPL A
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 508 AREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC--- 564
A+ G + LLL + A+ NA + T L +A L++ L+ G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
TPL AA++ +E+ + LL G + +A + G T L A + GH ++ +LL A+
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
++ G TPL A+ GHV LI G V+ TT +T L +A G++ +V+ LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG-YTPLHVASHYGNIKLVKFLL 721
Query: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
H AD + K G + L +AA+ GHT +V LL
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Score = 221 bits (564), Expect = 6e-57
Identities = 166/474 (35%), Positives = 242/474 (51%), Gaps = 8/474 (1%)
Query: 243 SEGD-VNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
++GD ++ VR LL +++ T + + L +A G++ +A+VLL A R + G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
Query: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
TPL A HV++++LLL A ++A + +G T L A G++ +VK LL+ GAS
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
N TPL A AGH EVA+ LL+N A +N + + ++ L A GH MV+ LL
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
Query: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
Query: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
+A LL+ER A G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
Query: 542 CCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
+EVA L++ G TPL AAQEGH E+V LL+ AN + +G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
T L + GH VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
T ++ L A GH +V LLL +GA P DG+T L A + G+ SV
Sbjct: 730 KT-KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Score = 220 bits (560), Expect = 2e-56
Identities = 169/509 (33%), Positives = 248/509 (48%), Gaps = 38/509 (7%)
Query: 246 DVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPL 305
++N + LL G SVN + G + L +A G + ++LL A +E + K ++TPL
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK-TKDELTPL 276
Query: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
AA GHV+I ++LL H A + A++ G + + A G ++D V++LL+ A I+D
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 336
Query: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHS---------------------------- 397
+ TPL A GH VA++LL+ GA N+ +
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 398 -NEFKESALT---LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
+ ES LT +A + GHL +V+ LL+ GA ++ T L A GH EVA+ L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 454 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHE 513
L + A+VN A ++PL AA GH + LL+E A+ G+TPL AAREGH
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570
E V LL + A+ T++ T L +A G + VA+ L++ A TPL
Sbjct: 517 ETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Query: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
A +L++VK LL G + H+ G T L A + +VA LLQ G ES G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
TPL AA+ GH V L+SK AN N + T L L GH+ V ++L+ HG
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
+ G T L A+ G+ +V +LL +
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Score = 206 bits (525), Expect = 2e-52
Identities = 176/553 (31%), Positives = 253/553 (45%), Gaps = 35/553 (6%)
Query: 213 DEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLC 272
DE L A A + Q L A E + V+ LL G + N TE+G + L
Sbjct: 91 DEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 273 LACSAGYYELAQVLL-----------AMHANVEDRGI-----------------KGDITP 304
+A G+ + L+ A+H + K TP
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209
Query: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
L AA+ ++ + +LLL A VN G T L A G V +V++LL+ GA IE
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
Query: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
++ TPL A GHV ++ +LL++GA I + S + +A HL+ VR LL+
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484
A+ + T + T L A GH VA++LLD GA+ N A + +PL +A HV +
Sbjct: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 388
Query: 485 LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
LL++ GAS++ V + G TPL A+ GH +V LL +GA+ N + ET L +A
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARA 447
Query: 545 GFLEVADFLIKAGADIELGC---STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601
G EVA +L++ A + TPL AA+ GH +VK LL AN + T G T L
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
Query: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661
A GH + LL+ A ++ G TPL AA+ G V + L+ + A+ N
Sbjct: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAG 566
Query: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPN 721
N T L +A +L +V+LLL G P +G T L AAK V LL Y
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 722 NLLSAPPPDVTQL 734
+ + VT L
Sbjct: 627 SANAESVQGVTPL 639
Score = 199 bits (506), Expect = 3e-50
Identities = 146/412 (35%), Positives = 209/412 (50%), Gaps = 6/412 (1%)
Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
AC + V + LL G S++ TE G + L +A G+ + + LL A+ +K
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
+ TPL AA GH ++ K LL +KA VNA++ T L A G+ ++VK+LLE+ A+
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
GHTPL A GHVE LLE A + + + L +A G + + L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
Query: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
E+A L++ G S + +G TPL AA+EGH EMVALLL + AN N + T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
Query: 541 ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
G + VAD LIK G ++ TPL A+ G+++LVK+LL A+V+A T G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649
+ L A + GHTD+ +LL+ GA S G TPL A R G++ L
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 176 bits (446), Expect = 3e-43
Identities = 119/363 (32%), Positives = 191/363 (52%), Gaps = 45/363 (12%)
Query: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
T +TAL +A G +E+V+ L+ GA++ + +KGFTPL +AA H+ VV+ LL+N
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 1139 GADIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------E 1167
GA+ Q+ T+D TPL++A G + VV
Sbjct: 134 GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 1168 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1227
+LL N + + + +TPL +AA +N+ ++LLN GA +N + GI+PL +A+
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 248
Query: 1228 NGHTAAVKLLLDMGSDINAQIETNRNTALT---LACFQGRTEVVSLLLDRKANVEHRAKT 1284
G+ V+LLLD G AQIET LT A G + +LLD A ++ + K
Sbjct: 249 RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 1285 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1344
GL+P+ AA G + + R+LL A+++ + T L +AA GH++ ++L+ +GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 1345 HIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRY 1404
+ R G TPL +A H+ V++LL++ GA +DA +TPL A GH+ +V+
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 1405 LVK 1407
L++
Sbjct: 423 LLQ 425
Score = 172 bits (435), Expect = 5e-42
Identities = 124/333 (37%), Positives = 173/333 (51%), Gaps = 7/333 (2%)
Query: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
IDA TES T L +A GH +V+ LL+RGAS + K TPL +AA AGH V +
Sbjct: 397 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
LL N A + A++ + TPL A G +V+LLL AN + +TPL +AA G
Sbjct: 456 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
+V + LL E + +K G +PL +AA G +LLL+ + NA + N T
Sbjct: 515 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
V T L +AA +GH + LL+ + A+ ++ NK G TPL L A GH+ V +L++
Sbjct: 632 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
G VDA TPL A G++K+V++L++
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Score = 168 bits (426), Expect = 6e-41
Identities = 124/362 (34%), Positives = 188/362 (51%), Gaps = 34/362 (9%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
+++AQ++ T L +A H E+V+ LLE GA+ + GFTPL +A GH VV
Sbjct: 103 NVNAQSQKGF-TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 161
Query: 1134 ILLDNGAD---------IEAQSERTKD-------------------TPLSLACSGGRQEV 1165
L++ G I A+++ T+ TPL +A V
Sbjct: 162 HLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNV 221
Query: 1166 VELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA 1225
+LLL RGA+ + TPL +A+ G V ++++LL+ GA+I ++T +L +PL A
Sbjct: 222 AQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCA 279
Query: 1226 AMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1285
A NGH ++LLD G+ I A+ + N + + +A + V LLL A ++
Sbjct: 280 ARNGHVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 1286 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH 1345
LTPL AA G+ V +VLLDKGA N+ + T L IA K H + ELL+ GA
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGAS 396
Query: 1346 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYL 1405
ID + G TPL +A+ GHL +V+ L+Q GA + ++ + TPL A R GH +V +YL
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 1406 VK 1407
++
Sbjct: 457 LQ 458
Score = 164 bits (414), Expect = 1e-39
Identities = 119/335 (35%), Positives = 171/335 (51%), Gaps = 15/335 (4%)
Query: 1075 IDAQT-ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
+D T N L LA GH ++V LL + +E KKG T L +AA AG VV
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
L++ GA++ AQS++ TPL +A EVV+ LL GAN+ +TPL++A
Sbjct: 96 ELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
Query: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG--HTAAVKLLLDMGSDINAQIETN 1251
G+ N++ L+N G T K+ + L +AA N TAAV L D D+ +
Sbjct: 155 GHENVVAHLINYG------TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV---LSKT 205
Query: 1252 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311
T L +A V LLL+R A+V + G+TPL A+ G + R+LLD+GA +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
T L AA GH + E+L+ GA I + K G +P+ +AA G HLD V+L
Sbjct: 266 ETK--TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
L+Q A++D +TPL A GH +V + L+
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Score = 63.9 bits (154), Expect = 2e-09
Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 2/131 (1%)
Query: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336
+V R T + AA G + L G D+N + L +A+ +GH K
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
Query: 1337 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1396
L+ + ++ KKGNT L +AA G +VV+ LV GA+V+A + TPL A ++
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 1397 GHVKVVRYLVK 1407
H++VV++L++
Sbjct: 122 NHLEVVKFLLE 132
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 184 bits (468), Expect = 8e-46
Identities = 133/407 (32%), Positives = 204/407 (50%), Gaps = 6/407 (1%)
Query: 347 VDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT 406
+ +K LLE +++ NE G TPLM A G++E+ + L++NGA N + +AL
Sbjct: 18 IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALI 76
Query: 407 LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466
A +GH+ +V LL+ G + EH+ TALM AC G +V LLL GA ++
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
Query: 467 FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526
P+ AA GH ++ LL++ GA + + G TPL+ AAR+GH E V LL GA++
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
Query: 527 NAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYL 583
+ Q TAL +A GG+ + ++K ++ L +T LM A++EGH E+V+ L
Sbjct: 197 D-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Query: 584 LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHV 643
L AG V+ +GDT L A GH ++ LLQ AD++ + +T L A G+
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
Query: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703
V+ ++ + T + + T L A ++ VVELLL GA + K G T L
Sbjct: 316 TMVRDILQCNPDTEICTKDGE-TPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI 374
Query: 704 AAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQ 750
A +G + LL P + P+ TP + D + + Q
Sbjct: 375 AIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQ 421
Score = 172 bits (436), Expect = 4e-42
Identities = 120/333 (36%), Positives = 175/333 (52%), Gaps = 7/333 (2%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
D+D + E T L +A G+ E+V+ L++ GA+ D +T LI A+ GHV +VE
Sbjct: 30 DVDERNECGQ-TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVE 88
Query: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
LL G ++E + T L AC GR +VVELLL+ GAN + P+ AA
Sbjct: 89 ELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGR 147
Query: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253
G+ +I+ +LL GA++N K G +PL+ AA GH VK LL MG+D++ Q N
Sbjct: 148 GHADIVHLLLQNGAKVN--CSDKYGTTPLVWAARKGHLECVKHLLAMGADVD-QEGANSM 204
Query: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1313
TAL +A G T+ V +L R NV K G T LM A+ G+ E+ + LLD G VN
Sbjct: 205 TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI 264
Query: 1314 PPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373
P S DT L A GH + L+ + A ID+R + T L+ A G+ +V+ ++
Sbjct: 265 P--DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDIL 322
Query: 1374 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
Q D + TPL+ A + +++VV L+
Sbjct: 323 QCNPDTEICTKDGETPLIKATKMRNIEVVELLL 355
Score = 168 bits (425), Expect = 7e-41
Identities = 117/380 (30%), Positives = 190/380 (50%), Gaps = 6/380 (1%)
Query: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLM 372
++ +K LL DV+ ++ G T L A G +++VK L+++GA+ + + T L+
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 373 EAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD 432
A GHV + LL+ G + H + +AL ACYKG ++V LL GA+
Sbjct: 77 SASKEGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
Query: 433 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAS 492
++ A GH ++ LLL +GA+VN +PL AA GH+E L+ GA
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
Query: 493 LEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADF 552
+++ T L+ A + G+ + V +L + N+N T++ TAL +A G E+
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQD 254
Query: 553 LIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGH 609
L+ AG + + T L+ A + GH+E+V+ LL A++ TAL +A E G+
Sbjct: 255 LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGN 314
Query: 610 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLS 669
+ +LQ D E ++ G TPL+KA + ++ V+ L+ KGA V+ D T L
Sbjct: 315 ATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGD-TPLH 373
Query: 670 LACAGGHLAVVELLLAHGAD 689
+A G + ELLL + D
Sbjct: 374 IAIRGRSRKLAELLLRNPKD 393
Score = 153 bits (387), Expect = 2e-36
Identities = 108/323 (33%), Positives = 167/323 (51%), Gaps = 6/323 (1%)
Query: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
TAL A GH +V+ LL+ G ++EHRD G+T L+ A G VVE+LL +GA+ +
Sbjct: 73 TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN-PS 131
Query: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204
+ P+ A G ++V LLL GA + TPL AA G++ +K LL
Sbjct: 132 VTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA 191
Query: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264
GA+++ + + + L++A G+T +VK +L ++N + + NTAL +A +G
Sbjct: 192 MGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGH 248
Query: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1324
TE+V LLD V ++G T L+ A GG+ E+ R LL K AD++ TAL
Sbjct: 249 TEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIR--GQDNKTAL 306
Query: 1325 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADN 1384
A +KG+ ++ ++ K G TPL A +++VV+LL+ GA V A D
Sbjct: 307 YWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDK 366
Query: 1385 RKITPLMAAFRKGHVKVVRYLVK 1407
+ TPL A R K+ L++
Sbjct: 367 KGDTPLHIAIRGRSRKLAELLLR 389
Score = 152 bits (383), Expect = 5e-36
Identities = 111/359 (30%), Positives = 183/359 (50%), Gaps = 6/359 (1%)
Query: 284 QVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACA 343
+ LL +V++R G TPLM AA G+++IVK L+ + A+ N + TAL A
Sbjct: 22 KALLEKCKDVDERNECGQ-TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
Query: 344 GGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKES 403
G+V +V+ LL+ G ++E + G T LM A G +V LLL +GA + + +
Sbjct: 81 EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV-TGLYSVY 139
Query: 404 ALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP 463
+ A +GH ++V LL+ GA T L+ A GH+E + LL GA V+
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
Query: 464 ADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523
+ + L +A GG+ + +++R ++ + +G T LM A++EGH E+V LL G
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAG 259
Query: 524 ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELV 580
+N + + +T L A GG +E+ L++ ADI++ T L A ++G+ +V
Sbjct: 260 TYVNI-PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
Query: 581 KYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
+ +L + T G+T L A + + +V ++LL GA + + G TPL A R
Sbjct: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR 377
Score = 137 bits (346), Expect = 1e-31
Identities = 99/335 (29%), Positives = 168/335 (50%), Gaps = 4/335 (1%)
Query: 226 STANAGQSDN-RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQ 284
+ N DN +L A EG V+ V +LL G ++ G + L AC G ++ +
Sbjct: 62 ANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVE 121
Query: 285 VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344
+LL+ AN G+ + P++ AA GH IV LLL + A VN G T L +A
Sbjct: 122 LLLSHGANPSVTGLY-SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARK 180
Query: 345 GYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESA 404
G+++ VK LL GA ++ N T L+ A G+ + + +L+ +N +++ +A
Sbjct: 181 GHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTA 239
Query: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464
L +A +GH E+V+ LL+AG T L+ A GHVE+ R LL A +++
Sbjct: 240 LMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG 299
Query: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524
++ L A G+ + +++ E +G TPL++A + + E+V LLL +GA
Sbjct: 300 QDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGA 359
Query: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGAD 559
++A ++ +T L +A G ++A+ L++ D
Sbjct: 360 KVSA-VDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
Score = 137 bits (345), Expect = 1e-31
Identities = 102/306 (33%), Positives = 158/306 (51%), Gaps = 9/306 (2%)
Query: 413 HLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 472
++ ++ LLE D + + + T LM A G++E+ + L+ +GA N+ + L
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532
A+ GHV + L++ G +LE + G+T LM A +G ++V LLL GAN + T
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV-TGL 135
Query: 533 TQETALTLACCGGFLEVADFLIKAGADIELGCS-----TPLMEAAQEGHLELVKYLLAAG 587
+ A G ++ L++ GA ++ CS TPL+ AA++GHLE VK+LLA G
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGA--KVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
Query: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQ 647
A+V A TAL A + G+T +L+ ++ + G T LM A++ GH VQ
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
Query: 648 FLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 707
L+ G VN + D TVL A GGH+ +V LL AD R +D T L A +
Sbjct: 254 DLLDAGTYVNIPDRSGD-TVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
Query: 708 GHTSVV 713
G+ ++V
Sbjct: 313 GNATMV 318
Score = 131 bits (329), Expect = 1e-29
Identities = 105/349 (30%), Positives = 178/349 (51%), Gaps = 17/349 (4%)
Query: 1128 HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL 1187
++ ++ LL+ D++ ++E TPL +A G E+V+ L+ GAN ++ ++T L
Sbjct: 17 NIPALKALLEKCKDVDERNE-CGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
Query: 1188 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 1247
A+ G+V+I++ LL G + R G + LM A G T V+LLL G++ +
Sbjct: 76 ISASKEGHVHIVEELLKCGVNLEHRDMG--GWTALMWACYKGRTDVVELLLSHGANPSV- 132
Query: 1248 IETNRNTALTL--ACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1305
T + + A +G ++V LLL A V K G TPL+ AA G+ E + LL
Sbjct: 133 --TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL 190
Query: 1306 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGH 1365
GADV+ S TAL +A G+ + + ++ R ++++ +K GNT L +A+ GH
Sbjct: 191 AMGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGH 248
Query: 1366 LDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK---EVNQFPSDSECMRYI 1422
++VQ L+ AG V+ D T L+ A R GHV++VR L++ +++ D++ Y
Sbjct: 249 TEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYW 308
Query: 1423 A----TITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEK 1467
A T + +C+ E + + +A K +I + EL L+K
Sbjct: 309 AVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDK 357
Score = 122 bits (305), Expect = 6e-27
Identities = 94/270 (34%), Positives = 136/270 (50%), Gaps = 9/270 (3%)
Query: 1090 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 1149
A GH ++V LL+ GA + DK G TPL+ AA GH+ V+ LL GAD++ + +
Sbjct: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
Query: 1150 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 1209
T L +A GG + V+ +L R N + T L +A+ G+ I++ LL+AG +
Sbjct: 204 M-TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYV 262
Query: 1210 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS 1269
N + G + L+ A GH V+ LL +DI+ + + N+ TAL A +G +V
Sbjct: 263 N--IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVR 319
Query: 1270 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1329
+L + E K G TPL++A EV +LLDKGA V+A V DT L IA
Sbjct: 320 DILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA--VDKKGDTPLHIAIR 377
Query: 1330 KGHYKFCELLIGR---GAHIDVRNKKGNTP 1356
K ELL+ G + NK G TP
Sbjct: 378 GRSRKLAELLLRNPKDGRLLYRPNKAGETP 407
Score = 85.5 bits (210), Expect = 6e-16
Identities = 65/201 (32%), Positives = 108/201 (53%), Gaps = 6/201 (2%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
D+D Q +N TAL +A GG+ + V+ +L+R ++ DK G T L++A+ GH +V+
Sbjct: 195 DVD-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
Query: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
LLD G + +R+ DT L A GG E+V LL + A+ + R + T L A
Sbjct: 254 DLLDAGTYVNI-PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
Query: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253
G +++ +L + T K G +PL+ A + V+LLLD G+ ++A ++ +
Sbjct: 313 GNATMVRDILQCNPDTEICT--KDGETPLIKATKMRNIEVVELLLDKGAKVSA-VDKKGD 369
Query: 1254 TALTLACFQGRTEVVSLLLDR 1274
T L +A +GR+ ++ LL R
Sbjct: 370 TPLHIA-IRGRSRKLAELLLR 389
Score = 69.3 bits (168), Expect = 5e-11
Identities = 49/153 (32%), Positives = 73/153 (47%), Gaps = 1/153 (0%)
Query: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
S ++ +E ++ +K LL +V G T L A E G+ ++ L++ GA+
Sbjct: 6 SQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN 65
Query: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
E T L+ A++ GHV V+ L+ G N+ T L AC G VVELLL
Sbjct: 66 LEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG-WTALMWACYKGRTDVVELLL 124
Query: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
+HGA+P+ +I AA GH +V LL
Sbjct: 125 SHGANPSVTGLYSVYPIIWAAGRGHADIVHLLL 157
Score = 43.1 bits (100), Expect = 0.004
Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 2/91 (2%)
Query: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD-- 1141
+T L A + E+V+ LL++GA + DKKG TPL +A + E+LL N D
Sbjct: 336 ETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGR 395
Query: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLAR 1172
+ + + +TP ++ CS + + ++ AR
Sbjct: 396 LLYRPNKAGETPYNIDCSHQKSILTQIFGAR 426
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 175 bits (443), Expect = 6e-43
Identities = 149/480 (31%), Positives = 230/480 (47%), Gaps = 23/480 (4%)
Query: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 292
+D L +A DV VR LL + ++N +E + L A G + Q+LL AN
Sbjct: 7 TDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGAN 66
Query: 293 VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352
V + +TPL AA + K++ LLLAH ADVNA+ T L A A +
Sbjct: 67 VNAKDTLW-LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEA 125
Query: 353 LLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKG 412
L +S+ + +G + L A +GH+E LLL GA +N ++ + L A + G
Sbjct: 126 LAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV-CDKKERQPLHWAAFLG 184
Query: 413 HLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 472
HLE+++ L+ GAD K + + L A G +EV + LL GA+++ P + L
Sbjct: 185 HLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALH 244
Query: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM-VALLLGQGANINAQTE 531
+A G +A L+ GA++ + ND+G+TPL AA + + + LL+ GA++N Q++
Sbjct: 245 IACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSK 304
Query: 532 ETQETALTLACCGGFLEVADFLIKAGADIELG---CSTPLMEAAQEGHLELVKYLLAAGA 588
E ++ L +A G + LI+ G++I+ +TPL AA+ GH L+ L+ GA
Sbjct: 305 E-GKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363
Query: 589 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648
+ L A G +D LL S G ++ + HV
Sbjct: 364 DTARRGIHDMFPLHLAVLFGFSDCCRKLL---------SSGQLYSIVSSLSNEHV----- 409
Query: 649 LISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 708
+S G ++N T N T L A +GG++ + LLL+ GAD R K G T L AA G
Sbjct: 410 -LSAGFDIN-TPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANG 467
Score = 143 bits (360), Expect = 3e-33
Identities = 161/550 (29%), Positives = 230/550 (41%), Gaps = 61/550 (11%)
Query: 228 ANAGQSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQ 284
A+ G D + L A + G + V+ LL G ++E G + L +AC G +A
Sbjct: 197 ADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAI 256
Query: 285 VLLAMHANVEDRGIKGDITPL-MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACA 343
L+ ANV KG TPL +AA + ++LL+ + ADVN QS G + L A
Sbjct: 257 ELVNAGANVNQPNDKG-FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAI 315
Query: 344 GGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKES 403
G ++L+++G+ I+ ++ G+TPL A GH + L+ NGA
Sbjct: 316 HGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD-TARRGIHDMF 374
Query: 404 ALTLACYKGHLEMVRFLLEAG--------ADQEH---------KTDEM-HTALMEACMDG 445
L LA G + R LL +G EH D + T L A G
Sbjct: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434
Query: 446 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLM 505
+VE LLL SGA + +PL AA G + A L+ GA + E + +G +PL
Sbjct: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494
Query: 506 EAA-------REGH-------EE--------------MVALLLGQGANINAQTEETQETA 537
AA E H EE + LL GA+ + + + TA
Sbjct: 495 YAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGY-TA 553
Query: 538 LTLACCGGFLEVADFLIKAG----ADIELGCS-TPLMEAAQEGHLELVKYLLAAGANVHA 592
+ A G + + L++ D+E +PL AA GH E +K L N+
Sbjct: 554 VHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDV 613
Query: 593 TTATGDTALTYACENGHTDVADVLLQAGAD-LEHESEGGRTPLMKAARAGHVCTVQFLIS 651
G TAL A E G T+ +VL GA L E + TPL AA +GH ++ LI
Sbjct: 614 RDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLID 673
Query: 652 KGANVNRTTANNDH--TVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH 709
G + T + + T L LA GH+ V LLL G+ G T L A G
Sbjct: 674 SGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGC 733
Query: 710 TSVVCYLLDY 719
+ LLD+
Sbjct: 734 EDCLAALLDH 743
Score = 141 bits (356), Expect = 7e-33
Identities = 145/510 (28%), Positives = 219/510 (42%), Gaps = 84/510 (16%)
Query: 259 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHA--NVEDRGIKGDITPLMAAANGGHVKI 316
S+N G S L A +G+ E +LL A NV D K + PL AA GH+++
Sbjct: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCD---KKERQPLHWAAFLGHLEV 188
Query: 317 VKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGS 376
+KLL+A AD+ + G L A A G ++VVK LL GA I++ N G+T L
Sbjct: 189 LKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTAL----- 243
Query: 377 AGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHT 436
H+ ACY G + L+ AGA+ D+ T
Sbjct: 244 --HI---------------------------ACYLGQDAVAIELVNAGANVNQPNDKGFT 274
Query: 437 ALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEE 495
L A + + + LL+++GA VN + +SPL +AA G + +LI+ G+ ++
Sbjct: 275 PLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDC 334
Query: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK 555
+ G TPL AAR GHE +++ L+ GA+ A+ L LA GF + L+
Sbjct: 335 ADKFGNTPLHVAARYGHELLISTLMTNGAD-TARRGIHDMFPLHLAVLFGFSDCCRKLLS 393
Query: 556 AGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADV 615
+G + S +++L+AG +++ G T L A G+ + ++
Sbjct: 394 SGQLYSIVSSLS------------NEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNL 441
Query: 616 LLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR-----------TTANND 664
LL +GADL + GRTPL AA G L++ GA VN A++
Sbjct: 442 LLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDT 501
Query: 665 HTVLSLACAGGHLA----------------VVELLLAHGADPTHRLKDGSTMLIEAAKGG 708
+ H A +E LL +GADP+ R + G T + AA G
Sbjct: 502 YRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYG 561
Query: 709 HTSVVCYLLDYPNNLLSAPPPDVTQLTPPS 738
+ + LL+ N L DV P S
Sbjct: 562 NRQNLELLLEMSFNCLE----DVESTIPVS 587
Score = 127 bits (319), Expect = 1e-28
Identities = 102/323 (31%), Positives = 158/323 (48%), Gaps = 7/323 (2%)
Query: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
T L A G ++Q LL GA++ +D TPL AA + + V+ +LL + AD+ A
Sbjct: 43 TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNA 102
Query: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204
+ ++ TPL +A + + E L ++ + S + L A G++ + +LLN
Sbjct: 103 R-DKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLN 161
Query: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264
GA +N K PL AA GH +KLL+ G+D+ + + L A G+
Sbjct: 162 KGASLN--VCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCK-DRKGYGLLHTAAASGQ 218
Query: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1324
EVV LL A ++ G T L A G V L++ GA+VN P T L
Sbjct: 219 IEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQP--NDKGFTPL 276
Query: 1325 TIAADKGHYKFC-ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1383
+AA + C ELL+ GA ++ ++K+G +PL +AA G Q+L+Q G+++D AD
Sbjct: 277 HVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCAD 336
Query: 1384 NRKITPLMAAFRKGHVKVVRYLV 1406
TPL A R GH ++ L+
Sbjct: 337 KFGNTPLHVAARYGHELLISTLM 359
Score = 126 bits (316), Expect = 3e-28
Identities = 150/565 (26%), Positives = 233/565 (41%), Gaps = 79/565 (13%)
Query: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
L A S G+V + LL G + + G + L A + G Y+ A L+ A V +
Sbjct: 427 LHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486
Query: 298 IKGDITPLMAAANGGHVKI---------------------------VKLLLAHKADVNAQ 330
KG AAA+ + + ++ LL + AD + +
Sbjct: 487 CKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLR 546
Query: 331 SSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGH--TPLMEAGSAGHVEVARLLLE 388
G TA+ YA A G +++LLE + + E+ +PL A GH E + L E
Sbjct: 547 DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAE 606
Query: 389 NGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMH-TALMEACMDGHV 447
++ ++ + +AL LA +G E V L GA K + T L A GH
Sbjct: 607 TLVNLDVRDHKGR-TALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHT 665
Query: 448 EVARLLLDSG--AQVNMPADSF-ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL 504
+ LL+DSG A + D++ ++PL LA GHV+ LL+E+G++ + + G T L
Sbjct: 666 DSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725
Query: 505 MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG------- 557
A G E+ +A LL A + + + + T + LA G V L++A
Sbjct: 726 HRGAVTGCEDCLAALLDHDAFVLCRDFKGR-TPIHLASACGHTAVLRTLLQAALSTDPLD 784
Query: 558 ADIELGCSTPLMEAAQEGHLELVKYLL--------------------------------- 584
A ++ +P+ A+ GH + ++ LL
Sbjct: 785 AGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLG 844
Query: 585 AAGAN-VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHV 643
A GA V++ A G T L A + +LLQ A++ GRT LM AA G
Sbjct: 845 ALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQT 904
Query: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTM--- 700
V+FL+ +G N +T L LAC+ GH ++LA D S +
Sbjct: 905 AAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMP 964
Query: 701 LIEAAKGGHTSVVCYLLDYPNNLLS 725
L AA+ G SVV LL + +L+
Sbjct: 965 LHIAARNGLASVVQALLSHGATVLA 989
Score = 124 bits (312), Expect = 9e-28
Identities = 114/377 (30%), Positives = 172/377 (45%), Gaps = 59/377 (15%)
Query: 1065 AMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAA 1124
A+ P+ ++++ + + +AL A GH E V LL +GAS+ DKK PL AA
Sbjct: 125 ALAPLLSSLNV---ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAA 181
Query: 1125 TAGHVGVVEILLDNGADI----------------EAQSERTK----------------DT 1152
GH+ V+++L+ GAD+ Q E K +T
Sbjct: 182 FLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNT 241
Query: 1153 PLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA-SGGYVNIIKILLNAGAEINS 1211
L +AC G+ V L+ GAN N +TPL +AA S +++L+N GA++N
Sbjct: 242 ALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301
Query: 1212 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1271
+ SK G SPL +AA++G ++L+ GS+I+ + NT L +A G ++S L
Sbjct: 302 Q--SKEGKSPLHMAAIHGRFTRSQILIQNGSEIDC-ADKFGNTPLHVAARYGHELLISTL 358
Query: 1272 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA------------------DVNA 1313
+ A+ R + PL A G+++ R LL G D+N
Sbjct: 359 MTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINT 418
Query: 1314 PPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373
P + T L AA G+ + LL+ GA + R+K G TPL AA G LV
Sbjct: 419 P--DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLV 476
Query: 1374 QAGADVDAADNRKITPL 1390
AGA V+ AD + +PL
Sbjct: 477 TAGAGVNEADCKGCSPL 493
Score = 114 bits (285), Expect = 1e-24
Identities = 107/371 (28%), Positives = 169/371 (45%), Gaps = 51/371 (13%)
Query: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV-VEILLDNGADI 1142
+TAL +AC G + + L+ GA++ + KGFTPL +AA + + + +E+L++NGAD+
Sbjct: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
Query: 1143 EAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1202
QS+ K +PL +A GR ++L+ G+ + + TPL +AA G+ +I L
Sbjct: 300 NYQSKEGK-SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
Query: 1203 LNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS------------------DI 1244
+ GA+ +R G + PL LA + G + + LL G DI
Sbjct: 359 MTNGAD-TARRGIH-DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDI 416
Query: 1245 NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1304
N R T L A G E ++LLL A++ R K G TPL AA+ G + L
Sbjct: 417 NTPDNLGR-TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTL 475
Query: 1305 LDKGADVN----------------------APPVPSSRDTALTIAADKGHYK---FC-EL 1338
+ GA VN P PSS D + K FC E
Sbjct: 476 VTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEF 535
Query: 1339 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADV--DAADNRKITPLMAAFRK 1396
L+ GA +R+++G T + AA G+ ++LL++ + D ++PL A
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595
Query: 1397 GHVKVVRYLVK 1407
GH + ++ L +
Sbjct: 596 GHCEALKTLAE 606
Score = 112 bits (279), Expect = 6e-24
Identities = 103/353 (29%), Positives = 154/353 (43%), Gaps = 32/353 (9%)
Query: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE- 1143
T L A +GG+ E + LL GA + RDK G TPL AA G L+ GA +
Sbjct: 425 TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484
Query: 1144 --------------------------AQSERTKDTPLSLACSGGRQEVVELLLARGANKE 1177
+ + +D PL + +E LL GA+
Sbjct: 485 ADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
Query: 1178 HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 1237
R+ YT + AA+ G +++LL S + +SPL LAA NGH A+K L
Sbjct: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL 604
Query: 1238 LDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKAN--VEHRAKTGLTPLMEAASG 1295
+ +++ + R TAL LA +G TE V +L A+ ++ R K TPL AA+
Sbjct: 605 AETLVNLDVRDHKGR-TALFLATERGSTECVEVLTAHGASALIKER-KRKWTPLHAAAAS 662
Query: 1296 GYAEVGRVLLDKGADVNAPPVPSSR-DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN 1354
G+ + +L+D G + V + T L +A GH LL+ +G+ D + +G
Sbjct: 663 GHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGR 722
Query: 1355 TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
T L A G D + L+ A V D + TP+ A GH V+R L++
Sbjct: 723 TALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQ 775
Score = 109 bits (272), Expect = 4e-23
Identities = 111/385 (28%), Positives = 171/385 (44%), Gaps = 27/385 (7%)
Query: 1040 TPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELV 1099
TP H+ AAS T + +I I +D QT L LA GH + V
Sbjct: 654 TPLHAAAAS---GHTDSLHLLIDSGERADITDVMDAYGQTP------LMLAIMNGHVDCV 704
Query: 1100 QTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACS 1159
LLE+G++ + D +G T L A G + LLD+ A + + + + TP+ LA +
Sbjct: 705 HLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGR-TPIHLASA 763
Query: 1160 GGRQEVVELLLARGANKEHRNV----SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGS 1215
G V+ LL + + + S Y+P+ A+ G+ + +++LL + + G+
Sbjct: 764 CGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGN 822
Query: 1216 KLGISPLMLAAMNGHTAAVKLLLD-MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR 1274
+PL A +N + ++LL +G+ I + T L A F + +LL
Sbjct: 823 P--FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQH 880
Query: 1275 KANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG-ADVNAPPVPSSRDTALTIAADKGHY 1333
+A V TG T LM AA G LL +G AD+ + +++TAL +A KGH
Sbjct: 881 QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTV--LDENKNTALHLACSKGHE 938
Query: 1334 KFCELLIGRGAH----IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP 1389
K C L+I I+ N PL +AA G VVQ L+ GA V A D TP
Sbjct: 939 K-CALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
Query: 1390 LMA-AFRKGHVKVVRYLVKEVNQFP 1413
+A A K + ++ + FP
Sbjct: 998 ALACAPNKDVADCLALILSTMKPFP 1022
Score = 108 bits (270), Expect = 7e-23
Identities = 135/513 (26%), Positives = 207/513 (40%), Gaps = 89/513 (17%)
Query: 212 LDEAAAALTRMRAE--STANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGES 269
L AAA+ T RAE + ++ ++ L E+ + + LL G + +G +
Sbjct: 493 LHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYT 552
Query: 270 LLCLACSAGYYELAQVLLAMHAN-VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVN 328
+ A + G + ++LL M N +ED ++PL AA GH + +K L +++
Sbjct: 553 AVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLD 612
Query: 329 AQSSTGNTALTYACAGGYVDVVKVLLESGAS-IEDHNENGHTPLMEAGSAGHVEVARLLL 387
+ G TAL A G + V+VL GAS + + TPL A ++GH + LL+
Sbjct: 613 VRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLI 672
Query: 388 ENG--AGINTHSNEFKESALTLACYKGHLEMVRFLLEAG-----ADQEHKTDEMHTALME 440
++G A I + + ++ L LA GH++ V LLE G AD +T +H +
Sbjct: 673 DSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRT-ALHRGAVT 731
Query: 441 ACMD-----------------------------GHVEVARLLLDSGAQVNMPAD-----S 466
C D GH V R LL + + P D S
Sbjct: 732 GCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTD-PLDAGVDYS 790
Query: 467 FESPLTLAACGGHVELAALLIER---------------------------------GASL 493
SP+ A+ GH + LL+E GA +
Sbjct: 791 GYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKI 850
Query: 494 EEVND-EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADF 552
D +G TPL AA + + +LL A +NA T+ T TAL A G +F
Sbjct: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNA-TDHTGRTALMTAAENGQTAAVEF 909
Query: 553 LIKAG-ADIEL---GCSTPLMEAAQEGHLELVKYLLAAGAN---VHATTATGDTALTYAC 605
L+ G AD+ + +T L A +GH + +LA + ++AT + L A
Sbjct: 910 LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969
Query: 606 ENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 638
NG V LL GA + E G TP + A
Sbjct: 970 RNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
Score = 105 bits (261), Expect = 8e-22
Identities = 120/418 (28%), Positives = 172/418 (41%), Gaps = 36/418 (8%)
Query: 224 AESTANAGQSDNR---SLAEACSEGDVNAVRKLLIEGRS--VNEHTEEGESLLCLACSAG 278
AE+ N D++ +L A G V L G S + E + L A S G
Sbjct: 605 AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS-G 663
Query: 279 YYELAQVLLAMHANVEDRGIKGDIT---------PLMAAANGGHVKIVKLLLAHKADVNA 329
+ + +L+ D G + DIT PLM A GHV V LLL + +A
Sbjct: 664 HTDSLHLLI-------DSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADA 716
Query: 330 QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389
G TAL G D + LL+ A + + G TP+ A + GH V R LL+
Sbjct: 717 ADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQA 776
Query: 390 GAG---INTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH 446
++ + S + A Y GH + + LLE + + T L A ++
Sbjct: 777 ALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQ 835
Query: 447 VEVARLLLDS-GAQ-VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL 504
+LL + GA+ VN +PL AA +V +L++ A + + G T L
Sbjct: 836 DSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 895
Query: 505 MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC 564
M AA G V LL +G +E + TAL LAC G + A ++ D+ L
Sbjct: 896 MTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLIN 955
Query: 565 ST------PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616
+T PL AA+ G +V+ LL+ GA V A G T N DVAD L
Sbjct: 956 ATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN--KDVADCL 1011
Score = 104 bits (259), Expect = 1e-21
Identities = 98/332 (29%), Positives = 154/332 (46%), Gaps = 21/332 (6%)
Query: 1087 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 1146
L LA GH E ++TL E +++ RD KG T L LA G VE+L +GA +
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
Query: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1203
+ K TPL A + G + + LL+ G + +V D TPL LA G+V+ + +LL
Sbjct: 649 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708
Query: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263
G+ ++ G + L A+ G + LLD + + + + T + LA G
Sbjct: 709 EKGSTADA--ADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCR-DFKGRTPIHLASACG 765
Query: 1264 RTEVVSLLLDR-------KANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316
T V+ LL A V++ +G +P+ A+ G+ + +LL+
Sbjct: 766 HTAVLRTLLQAALSTDPLDAGVDY---SGYSPMHWASYTGHEDCLELLLEHSPFSYLEGN 822
Query: 1317 PSSRDTALTIAADKGHYKFCELLIGR-GAHI-DVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
P T L A E+L+G GA I + R+ KG TPL AA ++ +++L+Q
Sbjct: 823 PF---TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQ 879
Query: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
A+V+A D+ T LM A G V +L+
Sbjct: 880 HQAEVNATDHTGRTALMTAAENGQTAAVEFLL 911
Score = 93.2 bits (230), Expect = 3e-18
Identities = 87/273 (31%), Positives = 134/273 (49%), Gaps = 15/273 (5%)
Query: 1149 TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY---TPLSLAASGGYVNIIKILLNA 1205
T PL A E V LL++ KE+ NV D TPL AA G V I+++LL +
Sbjct: 7 TDQPPLVQAIFSRDVEEVRSLLSQ---KENINVLDQERRTPLHAAAYVGDVPILQLLLMS 63
Query: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265
GA +N++ L ++PL AA + + + LLL +D+NA+ + T L +A T
Sbjct: 64 GANVNAK--DTLWLTPLHRAAASRNEKVLGLLLAHSADVNAR-DKLWQTPLHVAAANRAT 120
Query: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1325
+ L +++ ++G + L A G+ E +LL+KGA +N L
Sbjct: 121 KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV--CDKKERQPLH 178
Query: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1385
AA GH + +LL+ RGA + +++KG L AA G ++VV+ L++ GA++D +
Sbjct: 179 WAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAF 238
Query: 1386 KITPLMAAFRKGHVKVVRYLVK---EVNQFPSD 1415
T L A G V LV VNQ P+D
Sbjct: 239 GNTALHIACYLGQDAVAIELVNAGANVNQ-PND 270
Score = 92.0 bits (227), Expect = 7e-18
Identities = 74/228 (32%), Positives = 113/228 (49%), Gaps = 5/228 (2%)
Query: 1180 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD 1239
+++D PL A V ++ LL+ IN + +PL AA G ++LLL
Sbjct: 5 SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERR--TPLHAAAYVGDVPILQLLLM 62
Query: 1240 MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1299
G+++NA+ +T T L A +V+ LLL A+V R K TPL AA+ +
Sbjct: 63 SGANVNAK-DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATK 121
Query: 1300 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWL 1359
L + +N S +AL A GH + LL+ +GA ++V +KK PL
Sbjct: 122 CAEALAPLLSSLNV--ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHW 179
Query: 1360 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
AA GHL+V++LLV GAD+ D + L A G ++VV+YL++
Sbjct: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227
Score = 90.5 bits (223), Expect = 2e-17
Identities = 73/218 (33%), Positives = 106/218 (48%), Gaps = 5/218 (2%)
Query: 503 PLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL 562
PL++A E V LL Q NIN +E + T L A G + + L+ +GA++
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQE-RRTPLHAAAYVGDVPILQLLLMSGANVNA 69
Query: 563 GCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQA 619
+ TPL AA + +++ LLA A+V+A T L A N T A+ L
Sbjct: 70 KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
Query: 620 GADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAV 679
+ L GR+ L A +GH+ TV L++KGA++N + L A GHL V
Sbjct: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLN-VCDKKERQPLHWAAFLGHLEV 188
Query: 680 VELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
++LL+A GAD + + G +L AA G VV YLL
Sbjct: 189 LKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLL 226
Score = 86.3 bits (212), Expect = 4e-16
Identities = 76/286 (26%), Positives = 126/286 (44%), Gaps = 32/286 (11%)
Query: 438 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 497
L++A VE R LL +N+ +PL AA G V + LL+ GA++ +
Sbjct: 12 LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71
Query: 498 DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG 557
TPL AA +E+++ LLL A++NA+ + Q
Sbjct: 72 TLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQ----------------------- 108
Query: 558 ADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL 617
TPL AA + + L ++++ +G +AL +A +GH + ++LL
Sbjct: 109 --------TPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLL 160
Query: 618 QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677
GA L + R PL AA GH+ ++ L+++GA++ + +L A A G +
Sbjct: 161 NKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLG-CKDRKGYGLLHTAAASGQI 219
Query: 678 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNL 723
VV+ LL GA+ G+T L A G +V L++ N+
Sbjct: 220 EVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANV 265
Score = 66.6 bits (161), Expect = 3e-10
Identities = 58/177 (32%), Positives = 83/177 (46%), Gaps = 4/177 (2%)
Query: 293 VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352
V R KG TPL AAA +V +++LL H+A+VNA TG TAL A G V+
Sbjct: 851 VNSRDAKGR-TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909
Query: 353 LLESG-ASIEDHNENGHTPLMEAGSAGHVEVARLLLEN--GAGINTHSNEFKESALTLAC 409
LL G A + +EN +T L A S GH + A ++L G+ +N + L +A
Sbjct: 910 LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969
Query: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466
G +V+ LL GA +E HT + + V L+ S + P D+
Sbjct: 970 RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 172 bits (436), Expect = 4e-42
Identities = 132/396 (33%), Positives = 199/396 (50%), Gaps = 54/396 (13%)
Query: 313 HVKIVKLLLAHKADVNAQSSTGNTA--LTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
++K+ +LL+ A++N ++ N A L GY ++V +LLE GA+++ +E+G TP
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
Query: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE-----AGA 425
L A +AG++ + LL + A ++ H ++ + AL A +GHLE+V+FL++ AG
Sbjct: 922 LGYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980
Query: 426 DQE--HKTDEMHTALMEACMDGHVEVARLLLD---------SGAQVNMPADSF--ESPLT 472
Q K+ + AL+ A G+ E+ LLD AQ+N DS E+ LT
Sbjct: 981 QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWGETALT 1039
Query: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532
AA G +E+ LL+E+GA++ + N G PL R+GH ++V LLL GA++N ++
Sbjct: 1040 AAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQ 1099
Query: 533 TQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHA 592
+ TPLM AA EGHL V +LLA GA++
Sbjct: 1100 GR-------------------------------TPLMMAASEGHLGTVDFLLAQGASIAL 1128
Query: 593 TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
G TAL++AC GH V L+ GA +H + GRTPL AA G VQFL+
Sbjct: 1129 MDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 1188
Query: 653 GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
GA + + L A + +VV LL GA
Sbjct: 1189 GAMIEHVDYSGMRP-LDRAVGCRNTSVVVTLLKKGA 1223
Score = 150 bits (378), Expect = 2e-35
Identities = 109/333 (32%), Positives = 170/333 (51%), Gaps = 26/333 (7%)
Query: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV---EVARLLLDSGAQVNMPADS 466
Y ++++ R L+ GA+ ++T+ ++ A + C+ H+ E+ LLL+ GA V+ ++S
Sbjct: 859 YTPNIKVSRLLILGGANINYRTEVLNNAPI-LCVQSHLGYTEMVALLLEFGANVDASSES 917
Query: 467 FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL------ 520
+PL AA G++ + LL ++ A ++ ++ G L+ AA GH E+V L+
Sbjct: 918 GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 977
Query: 521 -GQGANINAQTEETQETALTLACCGGFLEVADFLI----KAGADIE---------LGCST 566
GQ + ++ Q+ AL A G+ E+ +L+ K ++E L T
Sbjct: 978 AGQQQGVFKKSHAIQQ-ALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGET 1036
Query: 567 PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 626
L AA G LE+ + LL GA V G L GH + D+LL GAD+
Sbjct: 1037 ALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMA 1096
Query: 627 SEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAH 686
+ GRTPLM AA GH+ TV FL+++GA++ T LS AC GHL+VV L+ +
Sbjct: 1097 DKQGRTPLMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGHLSVVRSLVDN 1155
Query: 687 GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
GA H K+G T L AA G VV +L+D+
Sbjct: 1156 GAATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 1188
Score = 147 bits (371), Expect = 1e-34
Identities = 117/370 (31%), Positives = 172/370 (46%), Gaps = 23/370 (6%)
Query: 246 DVNAVRKLLIEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDIT 303
++ R L++ G ++N TE +LC+ GY E+ +LL ANV D + +T
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANV-DASSESGLT 920
Query: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH 363
PL AA G++ IV LL +A V+ G AL +A G+++VVK L++ ++
Sbjct: 921 PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980
Query: 364 NEN----GHT---PLMEAGSAGHVEVARLLLE---------NGAGINTHSNEFKESALTL 407
+ H L+ A S G+ E+ LL+ A IN+ + + E+ALT
Sbjct: 981 QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTA 1040
Query: 408 ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
A +G LE+ R LLE GA L GH ++ LLL GA VNM
Sbjct: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100
Query: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
+PL +AA GH+ L+ +GAS+ ++ EG T L A +GH +V L+ GA +
Sbjct: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1160
Query: 528 AQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPLMEAAQEGHLELVKYLL 584
++ T L LA G EV FL+ GA IE PL A + +V LL
Sbjct: 1161 -HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219
Query: 585 AAGANVHATT 594
GA + T
Sbjct: 1220 KKGAKIGPAT 1229
Score = 130 bits (328), Expect = 1e-29
Identities = 150/503 (29%), Positives = 222/503 (44%), Gaps = 40/503 (7%)
Query: 1058 SPIISPSAMLPIYPAIDIDAQTES-NHDTALTLACAGGHEELVQTLLERGASIEHRDKKG 1116
+P I S +L I +I+ +TE N+ L + G+ E+V LLE GA+++ + G
Sbjct: 860 TPNIKVSRLL-ILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESG 918
Query: 1117 FTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLA----- 1171
TPL AA AG++ +V +L A ++ ++ L A G EVV+ L+
Sbjct: 919 LTPLGYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 977
Query: 1172 ----RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG---------AEINSRTGSKLG 1218
+G K+ + L AAS GY I+ LL+ A+INS S G
Sbjct: 978 AGQQQGVFKKSHAIQQ--ALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWG 1034
Query: 1219 ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL--ACFQGRTEVVSLLLDRKA 1276
+ L AA G +LLL+ G+ A + NR A+ L QG ++V LLL A
Sbjct: 1035 ETALTAAAGRGKLEVCRLLLEQGA---AVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 1091
Query: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336
+V K G TPLM AAS G+ LL +GA + + TAL+ A KGH
Sbjct: 1092 DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL--MDKEGLTALSWACLKGHLSVV 1149
Query: 1337 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1396
L+ GA D +K G TPL LAA G +VVQ LV GA ++ D + PL A
Sbjct: 1150 RSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGC 1209
Query: 1397 GHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNA 1456
+ VV L+K+ + + M + D ++ L E + K + EA +
Sbjct: 1210 RNTSVVVTLLKKGAKIGPATWAM--ATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRY 1267
Query: 1457 SILLEEL-------DLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKEN 1509
L++ DL+ RE L L R +RK EE K E++ K+ E
Sbjct: 1268 QYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEA 1327
Query: 1510 FELQAAQEKEKLKVEDEPEVLTE 1532
+ +A ++ + E L E
Sbjct: 1328 YYARARAKRSSRQFAAALEDLNE 1350
Score = 129 bits (324), Expect = 4e-29
Identities = 112/390 (28%), Positives = 164/390 (42%), Gaps = 63/390 (16%)
Query: 245 GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITP 304
G V LL G +V+ +E G + L A +AGY + +L A V+ G
Sbjct: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCA- 954
Query: 305 LMAAANGGHVKIVKLLL------------------------------------------- 321
L+ AA GH+++VK L+
Sbjct: 955 LVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLP 1014
Query: 322 ------AHKADVNA-QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEA 374
+A +N+ S G TALT A G ++V ++LLE GA++ N G PL
Sbjct: 1015 EKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFST 1074
Query: 375 GSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEM 434
GH ++ LLL +GA +N + + + L +A +GHL V FLL GA E
Sbjct: 1075 VRQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEG 1133
Query: 435 HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLE 494
TAL AC+ GH+ V R L+D+GA + + +PL LAA G E+ L++ GA +E
Sbjct: 1134 LTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1193
Query: 495 EVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT--EETQETALTLACCGGFLEVADF 552
V+ G PL A + +V LL +GA I T T + + + +E D
Sbjct: 1194 HVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDM 1253
Query: 553 LIKAGADIELGCSTPLMEAAQEGHLELVKY 582
K G + EAAQ L K+
Sbjct: 1254 FYKKG---------KVKEAAQRYQYALKKF 1274
Score = 129 bits (323), Expect = 5e-29
Identities = 112/359 (31%), Positives = 164/359 (45%), Gaps = 21/359 (5%)
Query: 379 HVEVARLLLENGAGINTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTA 437
+++V+RLL+ GA IN + + L + + G+ EMV LLE GA+ + ++ T
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
Query: 438 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE----RGASL 493
L A G++ + LL A+V+ + + L AA GH+E+ LI+
Sbjct: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
Query: 494 EEVNDEGYT---PLMEAAREGHEEMVALLLG---------QGANINAQTEETQETALTLA 541
+ V + + L+ AA G+ E+V+ LL + A IN+ ETALT A
Sbjct: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
Query: 542 CCGGFLEVADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
G LEV L++ GA + + PL ++GH ++V LL GA+V+ G
Sbjct: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
Query: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
T L A GH D LL GA + + G T L A GH+ V+ L+ GA +
Sbjct: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
Query: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
N T L LA G VV+ L+ HGA H G L A +TSVV LL
Sbjct: 1162 ADKNG-RTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219
Score = 65.1 bits (157), Expect = 9e-10
Identities = 49/157 (31%), Positives = 80/157 (50%), Gaps = 16/157 (10%)
Query: 576 HLELVKYLLAAGANVHATTATGDTALTYACEN--GHTDVADVLLQAGADLEHESEGGRTP 633
++++ + L+ GAN++ T + A ++ G+T++ +LL+ GA+++ SE G TP
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
Query: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA-------- 685
L AA AG++ V L K A V+ N ++ A G HL VV+ L+
Sbjct: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRG-HLEVVKFLIQCDWTMAGQ 980
Query: 686 -HGA-DPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
G +H ++ LI AA G+T +V YLLD P
Sbjct: 981 QQGVFKKSHAIQQA---LIAAASMGYTEIVSYLLDLP 1014
Score = 54.3 bits (129), Expect = 2e-06
Identities = 56/192 (29%), Positives = 80/192 (41%), Gaps = 11/192 (5%)
Query: 177 ALLEAAGIGKLSTA-----DGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAG 231
AL AAG GKL G A A P RR + + + + + A+
Sbjct: 1037 ALTAAAGRGKLEVCRLLLEQGAAVAQPN--RRGAVPLFSTVRQGHWQIVDLLLTHGADVN 1094
Query: 232 QSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 288
+D + L A SEG + V LL +G S+ +EG + L AC G+ + + L+
Sbjct: 1095 MADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVD 1154
Query: 289 MHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVD 348
A D K TPL AA G ++V+ L+ H A + +G L A
Sbjct: 1155 NGA-ATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTS 1213
Query: 349 VVKVLLESGASI 360
VV LL+ GA I
Sbjct: 1214 VVVTLLKKGAKI 1225
Score = 42.7 bits (99), Expect = 0.005
Identities = 52/224 (23%), Positives = 78/224 (34%), Gaps = 18/224 (8%)
Query: 1975 SSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTA 2034
S S+ P + SSP Q+F +S + T T +++ +PT+
Sbjct: 1442 SPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQN------ 1495
Query: 2035 KEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPN 2094
HY S P + PA GG R SP G +E SPP
Sbjct: 1496 -SHYRPSPPHTS--PAHQGGSYRFSPPPVGGQG---------KEYPSPPPSPLRRGPQYR 1543
Query: 2095 SSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP 2154
+S + S S + +Q P QE + P +M P PVAVP
Sbjct: 1544 ASPPAESMSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGL 1603
Query: 2155 VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNS 2198
P + QP+P + + + P H ++ Q+S
Sbjct: 1604 RLQPAKAQIVRSNQPSPAVHSSTVIPTGAYGQVAHSMASKYQSS 1647
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 167 bits (424), Expect = 1e-40
Identities = 167/553 (30%), Positives = 241/553 (43%), Gaps = 60/553 (10%)
Query: 209 SCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
+C+ A + + NA + N + L EA +G ++ LL G N +G
Sbjct: 256 ACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDG 315
Query: 268 ESLLCLACSA------GYYELAQVLLAMHANVEDR----------------GIKGDITPL 305
+S L LA + G Y+ ++L A + E++ G K TPL
Sbjct: 316 KSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKS--TPL 373
Query: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
AA V+IV+LLL H ADV+A+ G L AC+ G+ +V ++LL+ GA + +
Sbjct: 374 HLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDL 433
Query: 366 NGHTPLMEAGSAGHVEVARLLLENGAG---INTHSN-----------------EFKESAL 405
TPL EA S VEV LLL +GA +N H EFK +L
Sbjct: 434 WQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSL 493
Query: 406 TLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH---VEVARLLLDSGAQVNM 462
A + L V+ L + TAL A H +V LLL GA VN
Sbjct: 494 LQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNE 553
Query: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
F +PL +AA H ++ +L + GA + ++ G T L AA GH + LLL
Sbjct: 554 KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSY 613
Query: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG-CSTPLMEAAQEGHLELVK 581
G++ + + + T A G E ++ I L+EA++ G LE VK
Sbjct: 614 GSDPSIISLQ----GFTAAQMGN--EAVQQILSESTPIRTSDVDYRLLEASKAGDLETVK 667
Query: 582 YLLAAGANVHATTATG--DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
L + NV+ G T L +A V + LL GAD+ + +GG PL A
Sbjct: 668 Q-LCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACS 726
Query: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
GH + L+ GA+VN T L A A G + +LLL HGADPT + +DG+T
Sbjct: 727 YGHYEVAELLVRHGASVNVADLWK-FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNT 785
Query: 700 MLIEAAKGGHTSV 712
L + K G T +
Sbjct: 786 PL-DLVKEGDTDI 797
Score = 164 bits (415), Expect = 1e-39
Identities = 179/578 (30%), Positives = 251/578 (43%), Gaps = 85/578 (14%)
Query: 236 RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEG--ESLLCLACSAGYYELAQVLLAMHANV 293
R L EAC GDV+ V++ L++ +VN G S L A G ++ + LL M ANV
Sbjct: 184 RELLEACRNGDVSRVKR-LVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242
Query: 294 EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
R G + PL A + GH ++V LLL AD NA+ + T L A G +DV VL
Sbjct: 243 HARD-DGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
Query: 354 LESGASIEDHNENGHT--------------------PLMEAGSAGHVEVARLLLENGAGI 393
L+ GA N +G + L+EA +G+ E LL +
Sbjct: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALL-TPLNV 360
Query: 394 NTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 452
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
Query: 453 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN-------DEGYTP-- 503
LL GA VN +PL AA VE+ +LL+ GA VN D TP
Sbjct: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480
Query: 504 ------------LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG---GFLE 548
L++AARE V L IN + ++ ETAL A +
Sbjct: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLHPKRKQ 539
Query: 549 VADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYAC 605
V + L++ GA++ TPL AA+ H ++++ L GA ++A G TAL A
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599
Query: 606 ENGHTDVADVLLQAGAD---------------------LEHESEGGRTP-----LMKAAR 639
GH +LL G+D + ES RT L++A++
Sbjct: 600 LAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASK 659
Query: 640 AGHVCTVQFLISKGANVN-RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGS 698
AG + TV+ L S NVN R T L A ++VVE LL HGAD + K G
Sbjct: 660 AGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGL 718
Query: 699 TMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTP 736
L A GH V L+ + ++ A D+ + TP
Sbjct: 719 VPLHNACSYGHYEVAELLVRHGASVNVA---DLWKFTP 753
Score = 147 bits (370), Expect = 2e-34
Identities = 146/472 (30%), Positives = 214/472 (45%), Gaps = 30/472 (6%)
Query: 237 SLAEACSEGDVNAVRKLL-IEGRSVNEHTEEGESLLCLACSAG--YYELAQVLLAMHANV 293
SL +A E D+ V+K L +E + + +L C S ++ ++LL ANV
Sbjct: 492 SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV 551
Query: 294 EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
++ K +TPL AA H ++++L H A +NA + G TAL A G++ ++L
Sbjct: 552 NEKN-KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610
Query: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGH 413
L G+ + G T A G+ V ++L E+ I T +++ L A G
Sbjct: 611 LSYGSDPSIISLQGFT----AAQMGNEAVQQILSES-TPIRTSDVDYR---LLEASKAGD 662
Query: 414 LEMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 472
LE V+ L + + H T L A V V LL GA V+ PL
Sbjct: 663 LETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLH 722
Query: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532
A GH E+A LL+ GAS+ + +TPL EAA +G E+ LLL GA+ T++
Sbjct: 723 NACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGAD---PTKK 779
Query: 533 TQETALTLACCGGFLEVADFLIKAGADIE--LGCSTPLMEAAQEGHLELVKYLLAA-GAN 589
++ L D + + DI+ L L++AA++G L V+ L N
Sbjct: 780 NRDGNTPL----------DLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENIN 829
Query: 590 VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649
T T L A + +VA+ LL+ GAD+ + +GG PL AA GHV L
Sbjct: 830 CRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALL 889
Query: 650 ISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 701
I VN T T L A G + LLLAHGADPT + ++G T L
Sbjct: 890 IKYNTCVNATD-KWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPL 940
Score = 141 bits (355), Expect = 1e-32
Identities = 147/470 (31%), Positives = 207/470 (44%), Gaps = 68/470 (14%)
Query: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTG--NTALTYACAGGYVDVVKVLLE 355
+ G + L+ A G V VK L+ A+VNA+ G ++ L +A G DVV+ LL+
Sbjct: 179 VSGALRELLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQ 237
Query: 356 SGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLE 415
GA++ ++ G PL A S GH EV LLL GA N N + + L A KG ++
Sbjct: 238 MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDN-WNYTPLHEAAIKGKID 296
Query: 416 MVRFLLEAGADQ------------------------EHKTDEMHTALMEACMDGHVEVAR 451
+ LL+ GAD E+K DE L+EA G+ E
Sbjct: 297 VCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDE----LLEAARSGNEEKLM 352
Query: 452 LLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAR 509
LL + VN A +PL LAA V + LL++ GA + + G PL A
Sbjct: 353 ALL-TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACS 411
Query: 510 EGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL-GC---- 564
GH E+ LLL GA +NA + Q T L A +EV L+ GAD L C
Sbjct: 412 YGHYEVTELLLKHGACVNAM-DLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKS 470
Query: 565 -----STP--------------LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYAC 605
TP L++AA+E L VK LA + +TAL A
Sbjct: 471 AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV 530
Query: 606 ENGH---TDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662
+ H V ++LL+ GA++ +++ TPL AA H ++ L GA +N
Sbjct: 531 ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTL 590
Query: 663 NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
T L A GHL LLL++G+DP+ G T AA+ G+ +V
Sbjct: 591 G-QTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAV 635
Score = 122 bits (305), Expect = 6e-27
Identities = 101/297 (34%), Positives = 140/297 (47%), Gaps = 23/297 (7%)
Query: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139
E H T L A +V+ LL GA + +DK G PL A + GH V E+L+ +G
Sbjct: 681 EGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHG 740
Query: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199
A + ++ K TPL A + G+ E+ +LLL GA+ +N TPL L G I
Sbjct: 741 ASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGD--TDI 797
Query: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN-TALTL 1258
+ LL G + L+ AA G A V+ L +IN + RN T L L
Sbjct: 798 QDLLR-------------GDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNSTPLHL 843
Query: 1259 ACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1318
A EV LL+ A+V + K GL PL AAS G+ ++ +L+ VNA
Sbjct: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA--TDK 901
Query: 1319 SRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1375
T L AA KG + C LL+ GA ++N++G TPL LA D+ LL+ A
Sbjct: 902 WAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD---DIRALLIDA 955
Score = 117 bits (294), Expect = 1e-25
Identities = 113/356 (31%), Positives = 166/356 (46%), Gaps = 31/356 (8%)
Query: 1031 SGRASAMSNTPTHSIAASISQP-----QTPTPSPIISPSAMLPIYPAIDIDAQTESNHDT 1085
S + + S++PT S ++S S P ++P + + S + + P S
Sbjct: 125 SNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALR 184
Query: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKG--FTPLILAATAGHVGVVEILLDNGADIE 1143
L AC G V+ L++ A++ +D G +PL AA G VVE LL GA++
Sbjct: 185 ELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVH 243
Query: 1144 AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203
A+ + PL ACS G EVV LLL +GA+ R+ +YTPL AA G +++ +LL
Sbjct: 244 ARDDGGL-IPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302
Query: 1204 NAGAEINSR-TGSKLGI-----------------SPLMLAAMNGHTAAVKLLLDMGSDIN 1245
GA+ N R T K + L+ AA +G+ + LL ++N
Sbjct: 303 QHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALL-TPLNVN 361
Query: 1246 AQIETNR-NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1304
R +T L LA R +V LLL A+V + K GL PL A S G+ EV +L
Sbjct: 362 CHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL 421
Query: 1305 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLA 1360
L GA VNA + + T L AA K + C LL+ GA + N G + + +A
Sbjct: 422 LKHGACVNA--MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 117 bits (293), Expect = 1e-25
Identities = 107/314 (34%), Positives = 154/314 (49%), Gaps = 25/314 (7%)
Query: 249 AVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG-DITPLMA 307
AV+++L E + T + + L A AG E + L + NV R ++G TPL
Sbjct: 634 AVQQILSESTPIR--TSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHF 690
Query: 308 AANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENG 367
AA V +V+ LL H ADV+A+ G L AC+ G+ +V ++L+ GAS+ +
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
Query: 368 HTPLMEAGSAGHVEVARLLLENGAGI-------NTHSNEFKE------------SALTLA 408
TPL EA + G E+ +LLL++GA NT + KE +AL A
Sbjct: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDA 810
Query: 409 CYKGHLEMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
KG L V+ L T + T L A ++EVA LL+ GA VN
Sbjct: 811 AKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870
Query: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
PL AA GHV++AALLI+ + + +TPL EAA++G ++ ALLL GA+
Sbjct: 871 LIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 930
Query: 528 AQTEETQETALTLA 541
+ +E Q T L LA
Sbjct: 931 MKNQEGQ-TPLDLA 943
Score = 114 bits (285), Expect = 1e-24
Identities = 111/390 (28%), Positives = 167/390 (42%), Gaps = 69/390 (17%)
Query: 1075 IDAQTESNHDTALTLACAGGH---EELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 1131
I+ + +H+TAL A A H +++ + LL +GA++ ++K TPL +AA H V
Sbjct: 514 INFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDV 573
Query: 1132 VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 1191
+E+L +GA + A + T L A G + LLL+ G++ ++ +T AA
Sbjct: 574 MEVLHKHGAKMNAL-DTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AA 628
Query: 1192 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1251
G + +IL + S +L + A+ G VK L + +E
Sbjct: 629 QMGNEAVQQILSESTPIRTSDVDYRL-----LEASKAGDLETVKQLCSSQNVNCRDLEGR 683
Query: 1252 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311
+T L A R VV LL A+V + K GL PL A S G+ EV +L+ GA V
Sbjct: 684 HSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASV 743
Query: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRN--------------------- 1350
N + + T L AA KG Y+ C+LL+ GA +N
Sbjct: 744 NVADL--WKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLL 801
Query: 1351 ----------KKG-----------------------NTPLWLAANGGHLDVVQLLVQAGA 1377
KKG +TPL LAA +L+V + L++ GA
Sbjct: 802 RGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGA 861
Query: 1378 DVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
DV+A D + PL A GHV + L+K
Sbjct: 862 DVNAQDKGGLIPLHNAASYGHVDIAALLIK 891
Score = 110 bits (276), Expect = 1e-23
Identities = 101/376 (26%), Positives = 166/376 (44%), Gaps = 54/376 (14%)
Query: 1080 ESNHD--TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 1137
E N D T L +A H ++++ L + GA + D G T L AA AGH+ +LL
Sbjct: 553 EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLS 612
Query: 1138 NGAD-----------------------IEAQSERTKDTP---LSLACSGGRQEVVELLLA 1171
G+D E+ RT D L + +G + V +L +
Sbjct: 613 YGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSS 672
Query: 1172 RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHT 1231
+ N TPL AA V++++ LL+ GA+++++ K G+ PL A GH
Sbjct: 673 QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAK--DKGGLVPLHNACSYGHY 730
Query: 1232 AAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPL-- 1289
+LL+ G+ +N + + T L A +G+ E+ LLL A+ + + G TPL
Sbjct: 731 EVAELLVRHGASVNVA-DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
Query: 1290 ------------------MEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1330
++AA G A V ++ + ++N T L +AA
Sbjct: 790 VKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE--NINCRDTQGRNSTPLHLAAGY 847
Query: 1331 GHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1390
+ + E L+ GA ++ ++K G PL AA+ GH+D+ LL++ V+A D TPL
Sbjct: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
Query: 1391 MAAFRKGHVKVVRYLV 1406
A +KG ++ L+
Sbjct: 908 HEAAQKGRTQLCALLL 923
Score = 110 bits (274), Expect = 2e-23
Identities = 117/394 (29%), Positives = 176/394 (44%), Gaps = 27/394 (6%)
Query: 1120 LILAATAGHVGVVEILLDNGADIEAQSER-TKDTPLSLACSGGRQEVVELLLARGANKEH 1178
L+ A G V V+ L+D A++ A+ K +PL A GR++VVE LL GAN
Sbjct: 186 LLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244
Query: 1179 RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLL 1238
R+ PL A S G+ ++ +LL GA+ N+R +PL AA+ G +LL
Sbjct: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR--DNWNYTPLHEAAIKGKIDVCIVLL 302
Query: 1239 DMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1298
G+D N + T+ +AL LA D A + L+EAA G
Sbjct: 303 QHGADPNIR-NTDGKSALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNE 348
Query: 1299 EVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLW 1358
E LL +VN + T L +AA + +LL+ GA + ++K G PL
Sbjct: 349 EKLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLH 407
Query: 1359 LAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSEC 1418
A + GH +V +LL++ GA V+A D + TPL A K V+V L+ P+ C
Sbjct: 408 NACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH-GADPTLVNC 466
Query: 1419 MRYIATITDKEMLKKCHLCME----SIVQAKDRQAAEANKNASILLEELDLEKLREESRR 1474
A + L E S++QA R+A A ++ LE ++ + + +S
Sbjct: 467 HGKSAVDMAPTPELRERLTYEFKGHSLLQAA-READLAKVKKTLALEIINFK--QPQSHE 523
Query: 1475 LALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKE 1508
AL KR++ E RK + KNK+
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKD 557
Score = 98.6 bits (244), Expect = 7e-20
Identities = 102/313 (32%), Positives = 134/313 (42%), Gaps = 23/313 (7%)
Query: 1081 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKG--FTPLILAATAGHVGVVEILLDN 1138
S+ D L A G E V+ L ++ RD +G TPL AA V VVE LL +
Sbjct: 648 SDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHH 706
Query: 1139 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNI 1198
GAD+ A+ ++ PL ACS G EV ELL+ GA+ ++ +TPL AA+ G I
Sbjct: 707 GADVHAK-DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEI 765
Query: 1199 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL 1258
K+LL GA+ + ++ G +PL L D + Q + AL
Sbjct: 766 CKLLLKHGADPTKK--NRDGNTPLDLVKEG--------------DTDIQDLLRGDAALLD 809
Query: 1259 ACFQG-RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1317
A +G V L N TPL AA EV LL+ GADVNA
Sbjct: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
Query: 1318 SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1377
L AA GH LLI ++ +K TPL AA G + LL+ GA
Sbjct: 870 GL--IPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 927
Query: 1378 DVDAADNRKITPL 1390
D + TPL
Sbjct: 928 DPTMKNQEGQTPL 940
Score = 81.3 bits (199), Expect = 1e-14
Identities = 80/257 (31%), Positives = 116/257 (45%), Gaps = 47/257 (18%)
Query: 1177 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKL 1236
E VS PL A+G G + + +G+ + L+ A NG + VK
Sbjct: 155 EAAGVSSTAPLGPGAAG-----------PGTGVPAVSGA---LRELLEACRNGDVSRVKR 200
Query: 1237 LLDMGSDINAQIETNRNTA-LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASG 1295
L+D +++NA+ R ++ L A GR +VV LL ANV R GL PL A S
Sbjct: 201 LVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSF 259
Query: 1296 GYAEVGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCELLIGRGAHIDVRNK 1351
G+AEV +LL +GAD P++RD T L AA KG C +L+ GA ++RN
Sbjct: 260 GHAEVVSLLLCQGAD------PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNT 313
Query: 1352 KGNTPLWL---------------------AANGGHLDVVQLLVQAGADVDAADNRKITPL 1390
G + L L A +G ++ LL + A+D RK TPL
Sbjct: 314 DGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPL 373
Query: 1391 MAAFRKGHVKVVRYLVK 1407
A V++V+ L++
Sbjct: 374 HLAAGYNRVRIVQLLLQ 390
Score = 80.5 bits (197), Expect = 2e-14
Identities = 124/478 (25%), Positives = 191/478 (39%), Gaps = 50/478 (10%)
Query: 504 LMEAAREGHEEMVALLLGQGANINAQTEETQETA-LTLACCGGFLEVADFLIKAGADIEL 562
L+EA R G V L+ AN+NA+ ++++ L A G +V + L++ GA++
Sbjct: 186 LLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244
Query: 563 ---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQA 619
G PL A GH E+V LL GA+ +A T L A G DV VLLQ
Sbjct: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
Query: 620 GADLEHESEGGRTPL--------------------MKAARAGHVCTVQFLISKGANVN-R 658
GAD + G++ L ++AAR+G+ + L++ NVN
Sbjct: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP-LNVNCH 363
Query: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
+ T L LA + +V+LLL HGAD + K G L A GH V LL
Sbjct: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423
Query: 719 YPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEP------DKPPANVATTL 772
+ D+ Q T P H+ RV V +L ++ +P K ++A T
Sbjct: 424 HG---ACVNAMDLWQFT-PLHEAASKNRVEVCSL-LLSHGADPTLVNCHGKSAVDMAPTP 478
Query: 773 PIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIV--EEAQGKLTELEQRIKEAIEKNA 830
+R + + K S L A + + I+ ++ Q T L + K
Sbjct: 479 ELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRK 538
Query: 831 QLQSLEL---AHADQLTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQ 887
Q+ L L A+ ++ K+ + L+ E ++L + L Q L +
Sbjct: 539 QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRA 598
Query: 888 YL--EVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQ-----LSEGDYARLQQVDPVLLK 938
L ++ R+ L S L T +G + LSE R VD LL+
Sbjct: 599 ALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLE 656
Score = 68.6 bits (166), Expect = 8e-11
Identities = 41/114 (35%), Positives = 61/114 (53%), Gaps = 1/114 (0%)
Query: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
T+ + T L LA + E+ + LLE GA + +DK G PL AA+ GHV + +L+
Sbjct: 833 TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY 892
Query: 1139 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 1192
+ A +++ TPL A GR ++ LLLA GA+ +N TPL LA +
Sbjct: 893 NTCVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945
Score = 55.5 bits (132), Expect = 7e-07
Identities = 51/140 (36%), Positives = 65/140 (46%), Gaps = 9/140 (6%)
Query: 585 AAGANVHATTATGDTA-LTYACENGHTDVADVLLQAGADLEHESEGGR--TPLMKAARAG 641
AAG +G L AC NG L+ A A++ + GR +PL AA G
Sbjct: 169 AAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFG 227
Query: 642 HVCTVQFLISKGANVNRTTANNDHTVLSL--ACAGGHLAVVELLLAHGADPTHRLKDGST 699
V+ L+ GANV+ A +D ++ L AC+ GH VV LLL GADP R T
Sbjct: 228 RKDVVEHLLQMGANVH---ARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYT 284
Query: 700 MLIEAAKGGHTSVVCYLLDY 719
L EAA G V LL +
Sbjct: 285 PLHEAAIKGKIDVCIVLLQH 304
Score = 42.4 bits (98), Expect = 0.006
Identities = 47/165 (28%), Positives = 64/165 (38%), Gaps = 29/165 (17%)
Query: 1919 PAQSTWGPFPVRPLSPARATNSPK---------PHMVPRHSNQNSSGSQVNSAGSLTSSP 1969
P S P P PLSP A + P PRH G SP
Sbjct: 22 PGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSP 81
Query: 1970 TTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATY 2029
+S + TST + ++ V V V TS+A S +N +P++++
Sbjct: 82 DPVDGTSCCST--TSTICTVAAAPV-----VPAVSTSSAAGVAPNPAGSGSNNSPSSSSS 134
Query: 2030 PMPTAKEHYPVSSPSSP------SPPAQPGGVSRNSPLDCGSASP 2068
P ++ SSPSSP SP A GVS +PL G+A P
Sbjct: 135 PTSSSS-----SSPSSPGSSLAESPEA--AGVSSTAPLGPGAAGP 172
Score = 38.5 bits (88), Expect = 0.087
Identities = 42/165 (25%), Positives = 61/165 (36%), Gaps = 27/165 (16%)
Query: 2105 HSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPM 2164
H Q QP S P PP PPP P LA + P + ++ + P+ +
Sbjct: 14 HQQQLQPAPGASAPPPPP------PPP----LSPGLAPGTTPASPTASGLAPFASPRHGL 63
Query: 2165 GCPQPTPKMETPAIRP----PPHGTTAPHKNSA-----------SVQNSSVAVLSVNHI- 2208
P+ + P RP P GT+ S +V SS A ++ N
Sbjct: 64 ALPEGDGSRDPPD-RPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAG 122
Query: 2209 KRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGP 2253
++ PSS P++ S+ S A P A S+ P GP
Sbjct: 123 SGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGP 167
Score = 37.7 bits (86), Expect = 0.15
Identities = 27/91 (29%), Positives = 39/91 (42%)
Query: 2039 PVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSS 2098
P P SP P S S + +A+P A S+ AG P + + SSSS
Sbjct: 74 PPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSS 133
Query: 2099 SGSSSAHSNQQQPPGSVSQEPRPPLQQSQVP 2129
S +SS+ S+ P S+++ P S P
Sbjct: 134 SPTSSSSSSPSSPGSSLAESPEAAGVSSTAP 164
Score = 32.0 bits (71), Expect = 8.2
Identities = 33/149 (22%), Positives = 52/149 (34%)
Query: 1932 LSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSS 1991
L PA ++P P P S + G+ S + +P + + G + P
Sbjct: 18 LQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDR 77
Query: 1992 PSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ 2051
P + T ++ +T TV + ++A P +SPSS S P
Sbjct: 78 PRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTS 137
Query: 2052 PGGVSRNSPLDCGSASPNKVASSSEQEAG 2080
S +SP + SP SS G
Sbjct: 138 SSSSSPSSPGSSLAESPEAAGVSSTAPLG 166
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 167 bits (423), Expect = 1e-40
Identities = 150/448 (33%), Positives = 221/448 (49%), Gaps = 30/448 (6%)
Query: 154 LLSGTADGADLRTVDPETQARL--EALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCA 211
LLS G PE +R E+ L ++G GK L ++S S
Sbjct: 335 LLSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGKR-------------LSGVSSVDSAF 381
Query: 212 LDEAAAALTRMRAESTANAGQSD--NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGES 269
+ +L+ R ST++ G +D + L +A GD + + K+L + + V+ + G S
Sbjct: 382 SSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKIL-QPQDVDLALDSGAS 440
Query: 270 LLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNA 329
LL LA AG E A+ LL +AN +G TPL A +V+LLLA K VNA
Sbjct: 441 LLHLAVEAGQEECAKWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVNA 499
Query: 330 QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN 389
+ TAL +A G ++LLE AS+ + + G TP+ A G + R+LL
Sbjct: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559
Query: 390 GAGINTHSNEFKESALTL--ACYKGHLEMVRFLL-EAGADQEHKTDEMHTALMEACMDGH 446
G ++ K++ L L A ++GHL +V+ L + G +T + T L A GH
Sbjct: 560 GVDVSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616
Query: 447 VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLME 506
VAR+L+D + VN+ + ++PL +AA GH A LL+ RGA E + +GYT L
Sbjct: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHL 676
Query: 507 AAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA-DI--ELG 563
AAR GH V LL+ + A++ A+ Q TAL LA G EV + L+ A D+ E G
Sbjct: 677 AARNGHLATVKLLVEEKADVLARGPLNQ-TALHLAAAHGHSEVVEELVSADVIDLFDEQG 735
Query: 564 CSTPLMEAAQEGHLELVKYLLAAGANVH 591
S L AAQ H + V+ LL GA+++
Sbjct: 736 LSA-LHLAAQGRHAQTVETLLRHGAHIN 762
Score = 136 bits (343), Expect = 2e-31
Identities = 140/481 (29%), Positives = 218/481 (45%), Gaps = 28/481 (5%)
Query: 939 DEPQQTAAQMGF-APIQPLA--MPQALPLAAGPLPPGSIANLTELQGVI---VGQPVLGQ 992
DE ++TA + +P +P + +P L A+ P + L+EL + V Q V G
Sbjct: 292 DEVKETAHDLDVKSPPEPRSEVVPARLKRASAPTFDNDYS-LSELLSQLDSGVSQAVEGP 350
Query: 993 AQLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRAS---AMSNTPTHSIAASI 1049
+L+ + + + +S + + + +A S R S + P+ S +
Sbjct: 351 EELS-------RSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGTT 403
Query: 1050 SQPQTPTPSPIIS--PSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGA 1107
+ I+S S ++ I D+D +S + L LA G EE + LL A
Sbjct: 404 DVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGA-SLLHLAVEAGQEECAKWLLLNNA 462
Query: 1108 SIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVE 1167
+ +++G TPL +A GVVE+LL + A+ E + T L A G +
Sbjct: 463 NPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDE-DQWTALHFAAQNGDESSTR 521
Query: 1168 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1227
LLL + A+ + TP+ +A G NI++ILL G +++ + K PL AA
Sbjct: 522 LLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQ--GKDAWLPLHYAAW 579
Query: 1228 NGHTAAVKLLLDM-GSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGL 1286
GH VKLL G +NAQ R T L LA +G V +L+D ++V +
Sbjct: 580 QGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ 638
Query: 1287 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1346
TPL AA G+ R+LL +GA A + S TAL +AA GH +LL+ A +
Sbjct: 639 TPLHVAAETGHTSTARLLLHRGAGKEA--MTSDGYTALHLAARNGHLATVKLLVEEKADV 696
Query: 1347 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
R T L LAA GH +VV+ LV A +D D + ++ L A + H + V L+
Sbjct: 697 LARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLL 755
Query: 1407 K 1407
+
Sbjct: 756 R 756
Score = 131 bits (330), Expect = 8e-30
Identities = 117/344 (34%), Positives = 159/344 (46%), Gaps = 20/344 (5%)
Query: 350 VKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLAC 409
V + L+SGAS+ L A AG E A+ LL N A N SN + L +A
Sbjct: 431 VDLALDSGASL----------LHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAV 479
Query: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 469
+ +V LL K ++ TAL A +G RLLL+ A VN +
Sbjct: 480 ERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRT 539
Query: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ-GANINA 528
P+ +A G + +L+ RG + + + PL AA +GH +V LL Q G ++NA
Sbjct: 540 PMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNA 599
Query: 529 QTEETQETALTLACCGGFLEVADFLIKAGADIELGCS----TPLMEAAQEGHLELVKYLL 584
QT + + T L LA G VA LI +D+ + CS TPL AA+ GH + LL
Sbjct: 600 QTLDGR-TPLHLAAQRGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETGHTSTARLLL 657
Query: 585 AAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644
GA A T+ G TAL A NGH +L++ AD+ +T L AA GH
Sbjct: 658 HRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSE 717
Query: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
V+ L+S A+V + L LA G H VE LL HGA
Sbjct: 718 VVEELVS--ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
Score = 126 bits (316), Expect = 3e-28
Identities = 95/297 (31%), Positives = 148/297 (49%), Gaps = 8/297 (2%)
Query: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
T L +A +V+ LL R S+ +D+ +T L AA G +LL+ A +
Sbjct: 473 TPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNE 532
Query: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204
+ TP+ +AC G++ +V +LL RG + + + PL AA G++ I+K+L
Sbjct: 533 VDFEGR-TPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK 591
Query: 1205 A-GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263
G +N++T G +PL LAA GH ++L+D+ SD+N T L +A G
Sbjct: 592 QPGVSVNAQTLD--GRTPLHLAAQRGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETG 648
Query: 1264 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1323
T LLL R A E G T L AA G+ ++L+++ ADV A TA
Sbjct: 649 HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARG--PLNQTA 706
Query: 1324 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1380
L +AA GH + E L+ ID+ +++G + L LAA G H V+ L++ GA ++
Sbjct: 707 LHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 118 bits (296), Expect = 7e-26
Identities = 102/303 (33%), Positives = 150/303 (49%), Gaps = 21/303 (6%)
Query: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132
I ++A+ E TAL A G E + LLE+ AS+ D +G TP+ +A G +V
Sbjct: 495 ISVNAKDEDQW-TALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIV 553
Query: 1133 EILLDNGADIEAQSERTKDT--PLSLACSGGRQEVVELLLAR-GANKEHRNVSDYTPLSL 1189
ILL G D+ Q KD PL A G +V+LL + G + + + TPL L
Sbjct: 554 RILLRRGVDVSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
Query: 1190 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE 1249
AA G+ + +IL++ +++N S L +PL +AA GHT+ +LLL G+ A +
Sbjct: 611 AAQRGHYRVARILIDLCSDVN--VCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA-MT 667
Query: 1250 TNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1309
++ TAL LA G V LL++ KA+V R T L AA+ G++EV L+ A
Sbjct: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--SA 725
Query: 1310 DVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVV 1369
DV +AL +AA H + E L+ GAHI++++ L GGH
Sbjct: 726 DV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAA 776
Query: 1370 QLL 1372
LL
Sbjct: 777 TLL 779
Score = 118 bits (295), Expect = 9e-26
Identities = 83/278 (29%), Positives = 138/278 (49%), Gaps = 17/278 (6%)
Query: 1132 VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 1191
V++ LD+GA + L LA G++E + LL AN N TPL +A
Sbjct: 431 VDLALDSGASL-----------LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479
Query: 1192 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1251
++++LL +N++ + + L AA NG ++ +LLL+ + +N +++
Sbjct: 480 ERRVRGVVELLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEKNASVN-EVDFE 536
Query: 1252 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-GAD 1310
T + +AC G+ +V +LL R +V + K PL AA G+ + ++L + G
Sbjct: 537 GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596
Query: 1311 VNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQ 1370
VNA + T L +AA +GHY+ +LI + ++V + TPL +AA GH +
Sbjct: 597 VNAQTLDGR--TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654
Query: 1371 LLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
LL+ GA +A + T L A R GH+ V+ LV+E
Sbjct: 655 LLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE 692
Score = 106 bits (264), Expect = 3e-22
Identities = 94/308 (30%), Positives = 137/308 (44%), Gaps = 7/308 (2%)
Query: 431 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 490
TD L++A + G +L V++ DS S L LA G E A L+
Sbjct: 403 TDVQKKKLVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
Query: 491 ASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVA 550
A+ N G TPL A +V LLL + ++NA+ E+ Q TAL A G
Sbjct: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED-QWTALHFAAQNGDESST 520
Query: 551 DFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACEN 607
L++ A +++ TP+ A Q G +V+ LL G +V L YA
Sbjct: 521 RLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQ 580
Query: 608 GHTDVADVLL-QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666
GH + +L Q G + ++ GRTPL AA+ GH + LI ++VN + T
Sbjct: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVN-VCSLLAQT 639
Query: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSA 726
L +A GH + LLL GA DG T L AA+ GH + V L++ ++L+
Sbjct: 640 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLAR 699
Query: 727 PPPDVTQL 734
P + T L
Sbjct: 700 GPLNQTAL 707
Score = 67.8 bits (164), Expect = 1e-10
Identities = 58/176 (32%), Positives = 83/176 (47%), Gaps = 3/176 (1%)
Query: 227 TANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQV 285
+ NA D R+ L A G R L+ VN + ++ L +A G+ A++
Sbjct: 596 SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARL 655
Query: 286 LLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGG 345
LL A E G T L AA GH+ VKLL+ KADV A+ TAL A A G
Sbjct: 656 LLHRGAGKEAMTSDG-YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHG 714
Query: 346 YVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401
+ +VV+ L+ + I+ +E G + L A H + LL +GA IN S +F+
Sbjct: 715 HSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQ 769
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 166 bits (420), Expect = 3e-40
Identities = 190/685 (27%), Positives = 283/685 (41%), Gaps = 92/685 (13%)
Query: 114 NNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGA-DLRTVDPETQ 172
+ +E+ D E+ V +F+ D + +E L+LSG A D + P +
Sbjct: 4 HKTEDVNTLDSEKRTPLHVAAFLGDAEIIE--------LLILSGARVNAKDNMWLTPLHR 55
Query: 173 ARLEALLEAAGIGKLSTAD----GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTA 228
A EA + +AD K + P + +V CA E L S+
Sbjct: 56 AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCA--EVIIPLL-----SSV 108
Query: 229 NAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287
N R+ L A G V V LL +G ++N ++ L A G+ ++ +L+
Sbjct: 109 NVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLI 168
Query: 288 AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYV 347
A V + KG TPL AAA+ G + +VK LL +++ + GNTAL AC G
Sbjct: 169 NHGAEVTCKDKKG-YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQD 227
Query: 348 DVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVA-RLLLENGAGINTHSNEFKE---- 402
VV L++ GA++ N NG TPL A ++ H + LL+ NGA +N S + K
Sbjct: 228 AVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHM 287
Query: 403 ----------------------------SALTLACYKGHLEMVRFLLEAGADQEHKTDEM 434
+ L +A GH ++ L +GAD
Sbjct: 288 TAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHS 347
Query: 435 HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLE 494
L A ++ H + R LL SG +++ P + L AA GG+VE LL GA
Sbjct: 348 MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407
Query: 495 EVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGF-------- 546
+ + G TPL AA H + L+ GAN+N +T++ TAL A
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILG 466
Query: 547 --------LEVA------------DFLIKAGADIELGCS---TPLMEAAQEGHLELVKYL 583
LE A +FL++ A+ + + AA GH + ++ L
Sbjct: 467 NAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELL 526
Query: 584 LAAGANVHATTATGDTA--LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 641
L + + +G T L A NGH +VLLQ+ DL+ E GRT L AA G
Sbjct: 527 LERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKG 586
Query: 642 HVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP-THRLKD--GS 698
H V+ LI+ GA++ T L + GH + LLL +P +KD G
Sbjct: 587 HTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQ 646
Query: 699 TMLIEAAKGGHTSVVCYLLDYPNNL 723
T L+ A GH V LL+ N+
Sbjct: 647 TPLMLAVAYGHIDAVSLLLEKEANV 671
Score = 145 bits (367), Expect = 4e-34
Identities = 126/430 (29%), Positives = 198/430 (46%), Gaps = 26/430 (6%)
Query: 1040 TPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELV 1099
TP H AA+ + ++P+ ++++ ++ TAL A GH E+V
Sbjct: 84 TPLHVAAAN---------KAVKCAEVIIPLLSSVNV---SDRGGRTALHHAALNGHVEMV 131
Query: 1100 QTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACS 1159
LL +GA+I DKK L AA GH+ VV +L+++GA++ + ++ TPL A S
Sbjct: 132 NLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGY-TPLHAAAS 190
Query: 1160 GGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1219
G+ VV+ LL G + NV T L +A G ++ L++ GA +N + G
Sbjct: 191 NGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN--GF 248
Query: 1220 SPLMLAAMNGHTA-AVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANV 1278
+PL AA + H A ++LL++ G+D+N Q + ++ L + GR L+ +
Sbjct: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP-LHMTAVHGRFTRSQTLIQNGGEI 307
Query: 1279 EHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1338
+ K G TPL AA G+ + L GAD + S L +AA H C
Sbjct: 308 DCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM--FPLHLAALNAHSDCCRK 365
Query: 1339 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1398
L+ G ID +K G T L AA GG+++ ++LL +GAD D TPL A H
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425
Query: 1399 VKVVRYLV---KEVNQFPSDSECMRYIATITD----KEMLKKCHLCMESIVQAKDRQAAE 1451
+ LV VN+ + A +D K +L H E + +A++ + E
Sbjct: 426 FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKE 485
Query: 1452 ANKNASILLE 1461
A LL+
Sbjct: 486 ATLCLEFLLQ 495
Score = 141 bits (355), Expect = 1e-32
Identities = 107/322 (33%), Positives = 156/322 (48%), Gaps = 40/322 (12%)
Query: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
T L A A EE VQ L++ A + RDK TPL +AA V E+++ + +
Sbjct: 51 TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
Query: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204
S+R T L A G E+V LLLA+GAN + D L AA G+++++ +L+N
Sbjct: 111 -SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
Query: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264
GAE+ + K G +PL AA NG VK LL++G +I+ +I NTAL +AC+ G+
Sbjct: 170 HGAEVTCK--DKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQ 226
Query: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1324
VV+ L+D GA+VN P ++ T L
Sbjct: 227 DAVVN---------------------------------ELIDYGANVNQPN--NNGFTPL 251
Query: 1325 TIAADKGHYKFC-ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1383
AA H C ELL+ GA +++++K G +PL + A G Q L+Q G ++D D
Sbjct: 252 HFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVD 311
Query: 1384 NRKITPLMAAFRKGHVKVVRYL 1405
TPL A R GH ++ L
Sbjct: 312 KDGNTPLHVAARYGHELLINTL 333
Score = 139 bits (351), Expect = 3e-32
Identities = 118/399 (29%), Positives = 186/399 (46%), Gaps = 8/399 (2%)
Query: 320 LLAHKA-DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAG 378
+L HK DVN S T L A G +++++L+ SGA + + TPL A ++
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 379 HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL 438
E ++L+++ A +N + ++ L +A ++ ++ + TAL
Sbjct: 61 SEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
Query: 439 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND 498
A ++GHVE+ LLL GA +N L AA GH+++ ALLI GA + +
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
Query: 499 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 558
+GYTPL AA G +V LL G I+ + TAL +AC G V + LI GA
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGA 238
Query: 559 DIELGCS---TPLMEAAQEGHLEL-VKYLLAAGANVHATTATGDTALTYACENGHTDVAD 614
++ + TPL AA H L ++ L+ GA+V+ + G + L +G +
Sbjct: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
Query: 615 VLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAG 674
L+Q G +++ + G TPL AAR GH + L + GA+ + ++ L LA
Sbjct: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP-LHLAALN 357
Query: 675 GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
H LL+ G + K G T L AA GG+ +
Sbjct: 358 AHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECI 396
Score = 139 bits (349), Expect = 5e-32
Identities = 137/496 (27%), Positives = 206/496 (41%), Gaps = 43/496 (8%)
Query: 229 NAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287
N D +S L G + L+ G ++ ++G + L +A G+ L L
Sbjct: 275 NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334
Query: 288 AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYV 347
A+ GI + PL AA H + LL+ +++ G T L A AGG V
Sbjct: 335 TSGADTAKCGIHS-MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNV 393
Query: 348 DVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTL 407
+ +K+L SGA ++ G TPL A + H L+ GA +N ++++ +AL
Sbjct: 394 ECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHY 452
Query: 408 ACYKG----------------HLEMVR------------FLLEAGADQEHKTDEMHTALM 439
A LE R FLL+ A+ + E + ++
Sbjct: 453 AAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIH 512
Query: 440 EACMDGHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGASLEEVN 497
A GH + LLL+ +DS +SPL LAA GH + +L++ L+ +
Sbjct: 513 YAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRD 572
Query: 498 DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGG-------FLEVA 550
++G T L AA +GH E V L+ GA+I + T+ T L + G LE+A
Sbjct: 573 EKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIA 632
Query: 551 DFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHT 610
D G TPLM A GH++ V LL ANV G TAL GH
Sbjct: 633 DNPEAVDVKDAKG-QTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHE 691
Query: 611 DVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRT--TANNDHTVL 668
+ +LL+ + + GRTPL AA GH + L+ + N +T L
Sbjct: 692 ECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPL 751
Query: 669 SLACAGGHLAVVELLL 684
AC G+ +E+LL
Sbjct: 752 HWACYNGNENCIEVLL 767
Score = 137 bits (345), Expect = 1e-31
Identities = 154/572 (26%), Positives = 232/572 (40%), Gaps = 77/572 (13%)
Query: 221 RMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYY 280
R TA G L A + RKLL G ++ + G + L A + G
Sbjct: 334 RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNV 393
Query: 281 ELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340
E ++L + A+ + G TPL AA H ++ L+ A+VN G TAL Y
Sbjct: 394 ECIKLLQSSGADFHKKDKCGR-TPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHY 452
Query: 341 ACA----------GGYVD------------------VVKVLLESGASIEDHNENGHTPLM 372
A A G D ++ LL++ A+ ++ G+ +
Sbjct: 453 AAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIH 512
Query: 373 EAGSAGHVEVARLLLEN-GAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKT 431
A + GH + LLLE +G + +S L LA Y GH + + LL++ D + +
Sbjct: 513 YAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRD 572
Query: 432 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHVELAALLIERG 490
++ TAL A GH E L++ GA + + + + +PL + GH LL+E
Sbjct: 573 EKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIA 632
Query: 491 ASLEEVN---DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
+ E V+ +G TPLM A GH + V+LLL + AN++ + TAL G
Sbjct: 633 DNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDT-VDILGCTALHRGIMTGHE 691
Query: 548 EVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTAT---GDTAL 601
E L++ I S TPL AA GH + LL + G T L
Sbjct: 692 ECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPL 751
Query: 602 TYACENGHTDVADVLLQA----------------------------------GADLEHES 627
+AC NG+ + +VLL+ + +
Sbjct: 752 HWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRD 811
Query: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL-AH 686
+ GRTPL AA A HV +Q L+ A VN N+ T L +A G V++L+ +
Sbjct: 812 DKGRTPLRAAAFADHVECLQLLLRHSAPVN-AVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 687 GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
AD T + KD +T L A GH +LD
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
Score = 131 bits (329), Expect = 1e-29
Identities = 120/403 (29%), Positives = 181/403 (44%), Gaps = 19/403 (4%)
Query: 265 EEGESLLCLACSAGYYELAQVLLAM-HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323
+EG + + A + G+ + ++LL ++ E+ +PL AA GH + +++LL
Sbjct: 505 KEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQS 564
Query: 324 KADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI-EDHNENGHTPLMEAGSAGHVEV 382
D++ + G TAL A G+ + V+ L+ GASI N TPL + GH
Sbjct: 565 LVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLC 624
Query: 383 ARLLLENGAGINTHSNEFKESA----LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL 438
RLLLE N + + K++ L LA GH++ V LLE A+ + TAL
Sbjct: 625 LRLLLE--IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTAL 682
Query: 439 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV-- 496
M GH E ++LL+ + +PL AA GH + L++ S E+
Sbjct: 683 HRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCF 742
Query: 497 -NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK 555
+++GYTPL A G+E + +LL Q + T L A A L+
Sbjct: 743 KDNQGYTPLHWACYNGNENCIEVLLEQ--KCFRKFIGNPFTPLHCAIINDHGNCASLLLG 800
Query: 556 AGADIELGCS-----TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHT 610
A + C TPL AA H+E ++ LL A V+A +G TAL A ENG
Sbjct: 801 AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQA 860
Query: 611 DVADVLL-QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
D+L+ A ADL + + TPL A GH ++ K
Sbjct: 861 GAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903
Score = 127 bits (318), Expect = 2e-28
Identities = 120/394 (30%), Positives = 177/394 (44%), Gaps = 39/394 (9%)
Query: 1087 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 1146
L LA GH + ++ LL+ ++ RD+KG T L LAA GH VE L++ GA I +
Sbjct: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605
Query: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1203
TK TPL + G + LLL N E +V D TPL LA + G+++ + +LL
Sbjct: 606 NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
Query: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263
E N T LG + L M GH V++LL+ I + ++ T L A +G
Sbjct: 666 E--KEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARG 722
Query: 1264 RTEVVSLLLDRKANVE---HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320
+S LL + E + G TPL A G VLL++ P
Sbjct: 723 HATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF-- 780
Query: 1321 DTALTIAADKGHYKFCELLIGR--GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1378
T L A H LL+G + + R+ KG TPL AA H++ +QLL++ A
Sbjct: 781 -TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAP 839
Query: 1379 VDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCM 1438
V+A DN T LM A G V L VN +D T+ DK++ HL
Sbjct: 840 VNAVDNSGKTALMMAAENGQAGAVDIL---VNSAQAD-------LTVKDKDLNTPLHLA- 888
Query: 1439 ESIVQAKDRQAAEANKNASILLEELDLEKLREES 1472
++ ++ ++L+ L+K+++ES
Sbjct: 889 ----------CSKGHEKCALLI----LDKIQDES 908
Score = 116 bits (291), Expect = 3e-25
Identities = 85/269 (31%), Positives = 134/269 (49%), Gaps = 5/269 (1%)
Query: 452 LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREG 511
+L+ VN +PL +AA G E+ LLI GA + ++ TPL A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 512 HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPL 568
EE V +L+ A++NA+ ++ +T L +A ++ A+ +I + + + G T L
Sbjct: 61 SEEAVQVLIKHSADVNAR-DKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
Query: 569 MEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 628
AA GH+E+V LLA GAN++A AL +A GH DV +L+ GA++ + +
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
Query: 629 GGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
G TPL AA G + V+ L++ G ++ +T L +AC G AVV L+ +GA
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG-NTALHIACYNGQDAVVNELIDYGA 238
Query: 689 DPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
+ +G T L AA H ++ LL
Sbjct: 239 NVNQPNNNGFTPLHFAAASTHGALCLELL 267
Score = 115 bits (287), Expect = 7e-25
Identities = 119/435 (27%), Positives = 184/435 (42%), Gaps = 68/435 (15%)
Query: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV-VEILLDNGADI 1142
+TAL +AC G + +V L++ GA++ + GFTPL AA + H + +E+L++NGAD+
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
Query: 1143 EAQSERTK--------------------------------DTPLSLACSGGRQEVVELLL 1170
QS+ K +TPL +A G + ++ L
Sbjct: 275 NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334
Query: 1171 ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1230
GA+ + PL LAA + + + LL++G EI+ T K G + L AA G+
Sbjct: 335 TSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID--TPDKFGRTCLHAAAAGGN 392
Query: 1231 TAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLM 1290
+KLL G+D + + + R T L A + L+ ANV G T L
Sbjct: 393 VECIKLLQSSGADFHKKDKCGR-TPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALH 451
Query: 1291 EAASGGY----------------AEVGRVLLDKGADV------NAPPVPSSRD----TAL 1324
AA+ E R L +K A + PS RD ++
Sbjct: 452 YAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSI 511
Query: 1325 TIAADKGHYKFCELLIGRGAHIDVRNKKGNT--PLWLAANGGHLDVVQLLVQAGADVDAA 1382
AA GH + ELL+ R + G T PL LAA GH +++L+Q+ D+D
Sbjct: 512 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571
Query: 1383 DNRKITPLMAAFRKGHVKVVRYLVKE-VNQFPSDSECMRYIATITDKEMLKKCHLCMESI 1441
D + T L A KGH + V L+ + F D+ R T ++ LC+ +
Sbjct: 572 DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKR---TPLHASVINGHTLCLRLL 628
Query: 1442 VQAKDRQAAEANKNA 1456
++ D A K+A
Sbjct: 629 LEIADNPEAVDVKDA 643
Score = 102 bits (255), Expect = 4e-21
Identities = 73/222 (32%), Positives = 117/222 (52%), Gaps = 5/222 (2%)
Query: 1185 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 1244
TPL +AA G II++L+ +GA +N++ + ++PL A + AV++L+ +D+
Sbjct: 18 TPLHVAAFLGDAEIIELLILSGARVNAK--DNMWLTPLHRAVASRSEEAVQVLIKHSADV 75
Query: 1245 NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1304
NA+ + N T L +A + +++ ++V + G T L AA G+ E+ +L
Sbjct: 76 NAR-DKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134
Query: 1305 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGG 1364
L KGA++NA R AL AA GH LLI GA + ++KKG TPL AA+ G
Sbjct: 135 LAKGANINAFDKKDRR--ALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNG 192
Query: 1365 HLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
++VV+ L+ G ++D + T L A G VV L+
Sbjct: 193 QINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI 234
Score = 94.4 bits (233), Expect = 1e-18
Identities = 69/206 (33%), Positives = 105/206 (50%), Gaps = 5/206 (2%)
Query: 1201 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1260
+L++ ++N+ K +PL +AA G ++LL+ G+ +NA+ + T L A
Sbjct: 1 MLIHKTEDVNTLDSEKR--TPLHVAAFLGDAEIIELLILSGARVNAK-DNMWLTPLHRAV 57
Query: 1261 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320
E V +L+ A+V R K TPL AA+ + V++ + VN
Sbjct: 58 ASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD--RGG 115
Query: 1321 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1380
TAL AA GH + LL+ +GA+I+ +KK L AA GHLDVV LL+ GA+V
Sbjct: 116 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175
Query: 1381 AADNRKITPLMAAFRKGHVKVVRYLV 1406
D + TPL AA G + VV++L+
Sbjct: 176 CKDKKGYTPLHAAASNGQINVVKHLL 201
Score = 93.6 bits (231), Expect = 2e-18
Identities = 80/250 (32%), Positives = 121/250 (48%), Gaps = 14/250 (5%)
Query: 1072 AIDIDAQTESNHDTALTLACAG-------GHEELVQTLLERGASIEHRDKKGFTPLILAA 1124
A+ + + E+N DT L C GHEE VQ LLE+ SI +D +G TPL AA
Sbjct: 660 AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719
Query: 1125 TAGHVGVVEILLDNGADIE--AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 1182
GH + LL E + TPL AC G + +E+LL + ++ +
Sbjct: 720 ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-N 778
Query: 1183 DYTPLSLAASGGYVNIIKILLNA-GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 1241
+TPL A + N +LL A + I S K G +PL AA H ++LLL
Sbjct: 779 PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK-GRTPLRAAAFADHVECLQLLLRHS 837
Query: 1242 SDINAQIETNRNTALTLACFQGRTEVVSLLLD-RKANVEHRAKTGLTPLMEAASGGYAEV 1300
+ +NA ++ + TAL +A G+ V +L++ +A++ + K TPL A S G+ +
Sbjct: 838 APVNA-VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896
Query: 1301 GRVLLDKGAD 1310
++LDK D
Sbjct: 897 ALLILDKIQD 906
Score = 91.7 bits (226), Expect = 9e-18
Identities = 75/242 (30%), Positives = 116/242 (47%), Gaps = 5/242 (2%)
Query: 485 LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
+LI + + ++ E TPL AA G E++ LL+ GA +NA+ + T L A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAK-DNMWLTPLHRAVAS 59
Query: 545 GFLEVADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601
E LIK AD+ + TPL AA ++ + ++ ++V+ + G TAL
Sbjct: 60 RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
Query: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661
+A NGH ++ ++LL GA++ + R L AA GH+ V LI+ GA V
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT-CKD 178
Query: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPN 721
+T L A + G + VV+ LL G + G+T L A G +VV L+DY
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238
Query: 722 NL 723
N+
Sbjct: 239 NV 240
Score = 89.0 bits (219), Expect = 6e-17
Identities = 85/287 (29%), Positives = 126/287 (43%), Gaps = 12/287 (4%)
Query: 1072 AIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 1131
A+D+ ++ T L LA A GH + V LLE+ A+++ D G T L GH
Sbjct: 637 AVDVK---DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEEC 693
Query: 1132 VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKE---HRNVSDYTPLS 1188
V++LL+ I + R + TPL A + G + LL ++E ++ YTPL
Sbjct: 694 VQMLLEQEVSILCKDSRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLH 752
Query: 1189 LAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD-MGSDINAQ 1247
A G N I++LL G+ +PL A +N H LLL + S I +
Sbjct: 753 WACYNGNENCIEVLLEQKC-FRKFIGNP--FTPLHCAIINDHGNCASLLLGAIDSSIVSC 809
Query: 1248 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1307
+ T L A F E + LLL A V +G T LM AA G A +L++
Sbjct: 810 RDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN- 868
Query: 1308 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN 1354
A + +T L +A KGH K L++ + + N+K N
Sbjct: 869 SAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNN 915
Score = 76.3 bits (186), Expect = 4e-13
Identities = 72/278 (25%), Positives = 117/278 (42%), Gaps = 38/278 (13%)
Query: 259 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVK 318
+V+ +G++ L LA + G+ + +LL ANV+ I G T L GH + V+
Sbjct: 637 AVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMTGHEECVQ 695
Query: 319 LLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED---HNENGHTPLMEAG 375
+LL + + + S G T L YA A G+ + LL+ S ED + G+TPL A
Sbjct: 696 MLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWAC 755
Query: 376 SAGHVEVARLLLENG---------------AGINTHSN------------------EFKE 402
G+ +LLE A IN H N +
Sbjct: 756 YNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGR 815
Query: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG-AQVN 461
+ L A + H+E ++ LL A + TALM A +G +L++S A +
Sbjct: 816 TPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLT 875
Query: 462 MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDE 499
+ +PL LA GH + A L++++ +N++
Sbjct: 876 VKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
Score = 54.7 bits (130), Expect = 1e-06
Identities = 40/126 (31%), Positives = 56/126 (44%), Gaps = 4/126 (3%)
Query: 1049 ISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHD----TALTLACAGGHEELVQTLLE 1104
I P TP II+ ID+ S D T L A H E +Q LL
Sbjct: 776 IGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR 835
Query: 1105 RGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQE 1164
A + D G T L++AA G G V+IL+++ ++ +TPL LACS G ++
Sbjct: 836 HSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEK 895
Query: 1165 VVELLL 1170
L+L
Sbjct: 896 CALLIL 901
Score = 52.0 bits (123), Expect = 8e-06
Identities = 68/268 (25%), Positives = 100/268 (37%), Gaps = 72/268 (26%)
Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
A + G ++AV LL + +V+ G + L G+ E Q+LL ++ + +G
Sbjct: 652 AVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRG 711
Query: 301 DITPLMAAANGGHVKIVKLLLA---HKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
TPL AA GH + LL + D + + G T L +AC G + ++VLLE
Sbjct: 712 R-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQK 770
Query: 358 ---------------ASIEDH-------------------NENGHTPLMEAGSAGHVEVA 383
A I DH ++ G TPL A A HVE
Sbjct: 771 CFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECL 830
Query: 384 RLLLENGAGINTHSNEFK---------------------------------ESALTLACY 410
+LLL + A +N N K + L LAC
Sbjct: 831 QLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACS 890
Query: 411 KGHLEMVRFLLEAGADQEHKTDEMHTAL 438
KGH + +L+ D E +E + AL
Sbjct: 891 KGHEKCALLILDKIQD-ESLINEKNNAL 917
Score = 45.4 bits (106), Expect = 7e-04
Identities = 32/124 (25%), Positives = 61/124 (49%), Gaps = 3/124 (2%)
Query: 1338 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKG 1397
+LI + ++ + + TPL +AA G ++++LL+ +GA V+A DN +TPL A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 1398 HVKVVRYLVK---EVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANK 1454
+ V+ L+K +VN + + ++A + + + S V DR A
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 1455 NASI 1458
+A++
Sbjct: 121 HAAL 124
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 164 bits (415), Expect = 1e-39
Identities = 139/469 (29%), Positives = 217/469 (46%), Gaps = 7/469 (1%)
Query: 245 GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITP 304
GD + L++ G VN + + L A ++ E QVLL A+V R K TP
Sbjct: 52 GDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARD-KNWQTP 110
Query: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
L AA VK + L+ ++VN G TAL +A G+ ++VK+LL GA+I +
Sbjct: 111 LHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFD 170
Query: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
+ + A GH+EV +LL+ +GA + T ++ + L A G + +V++LL+ G
Sbjct: 171 KKDRRAIHWAAYMGHIEVVKLLVSHGAEV-TCKDKKSYTPLHAAASSGMISVVKYLLDLG 229
Query: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA- 483
D +T L AC +G V L+D GA VN + +PL AA H L
Sbjct: 230 VDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCL 289
Query: 484 ALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACC 543
LL+ GA + + +G TPL A G ++ GA I+ + ++ T L +A
Sbjct: 290 ELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE-DKNGNTPLHIAAR 348
Query: 544 GGFLEVADFLIKAGADIE---LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
G + + LI +GAD + PL AA G + + LL++G ++ G T
Sbjct: 349 YGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTC 408
Query: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
L A G+ + ++LL GAD + + GR+PL AA + + L+ GA+VN
Sbjct: 409 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD 468
Query: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH 709
+ A + +E LL + A+P R K G + +A GH
Sbjct: 469 ERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH 517
Score = 164 bits (414), Expect = 1e-39
Identities = 175/636 (27%), Positives = 270/636 (42%), Gaps = 71/636 (11%)
Query: 148 ETASKLLLSGTADGA-DLRTVDPETQARLEALLEAAGIGKLSTAD----GKAFADPEVLR 202
E L+LSG A D + + P +A EA + +AD K + P +
Sbjct: 55 EIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIA 114
Query: 203 RLTSSVSCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVN 261
+V CA EA L S N R+ L A G V+ LL G ++N
Sbjct: 115 AANKAVKCA--EALVPLL-----SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167
Query: 262 EHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL 321
++ + A G+ E+ ++L++ A V + K TPL AAA+ G + +VK LL
Sbjct: 168 AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD-KKSYTPLHAAASSGMISVVKYLL 226
Query: 322 AHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVE 381
D+N ++ GNT L AC G VV L++ GA + NE G TPL A ++ H
Sbjct: 227 DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGA 286
Query: 382 VA-RLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
+ LL+ NGA +N S + K + L + G + ++++GA + + +T L
Sbjct: 287 LCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345
Query: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500
A GH + L+ SGA PL LAA G + L+ G ++ +D G
Sbjct: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
Query: 501 YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI 560
T L AA G+ E + LLL GA+ N + ++ + L A + L+ +GA +
Sbjct: 406 RTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQCLFALVGSGASV 464
Query: 561 ----ELGCSTPLMEAAQEGHLELVKYLLAAGAN-----------VHATTATGD------- 598
E GC+ A + + ++YLL AN VH + A G
Sbjct: 465 NDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI 524
Query: 599 ---------------------------TALTYACENGHTDVADVLLQAGADLEHESEGGR 631
+ L A +GH +VL+Q+ DL+ + GR
Sbjct: 525 ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR 584
Query: 632 TPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPT 691
TPL AA GHV V LI++GA++ T + A GH + LL+ + A+P
Sbjct: 585 TPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGN-AEPQ 643
Query: 692 HRLK----DGSTMLIEAAKGGHTSVVCYLLDYPNNL 723
+ + +G T L+ + GHT V LL+ N+
Sbjct: 644 NAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV 679
Score = 160 bits (406), Expect = 1e-38
Identities = 140/475 (29%), Positives = 208/475 (43%), Gaps = 39/475 (8%)
Query: 234 DNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 293
D SL +A GD + VR L+ + VN E
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKR------------------------- 42
Query: 294 EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
TPL AAA G +I++LL+ A VNA+ S T L A A + V+VL
Sbjct: 43 ---------TPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVL 93
Query: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGH 413
L+ A + ++N TPL A + V+ A L+ + +N S+ +AL A + GH
Sbjct: 94 LKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV-SDRAGRTALHHAAFSGH 152
Query: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473
EMV+ LL GA+ + A+ A GH+EV +LL+ GA+V +PL
Sbjct: 153 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHA 212
Query: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533
AA G + + L++ G + E N G TPL A G + +V L+ GA +N + E+
Sbjct: 213 AASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKG 272
Query: 534 QETALTLACCGGFLEVADFLIKAGADIELGC---STPLMEAAQEGHLELVKYLLAAGANV 590
A + L+ GAD+ + TPL A G + ++ +GA +
Sbjct: 273 FTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVI 332
Query: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650
G+T L A GH + + L+ +GAD G PL AA +G + L+
Sbjct: 333 DCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLL 392
Query: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 705
S G +++ T + T L A AGG+L + LLL GAD + K G + L AA
Sbjct: 393 SSGFDID-TPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
Score = 157 bits (396), Expect = 2e-37
Identities = 136/465 (29%), Positives = 209/465 (44%), Gaps = 30/465 (6%)
Query: 245 GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITP 304
G + + ++ G ++ + G + L +A G+ L L+ A+ RGI G + P
Sbjct: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG-MFP 375
Query: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
L AA G + LL+ D++ G T L A AGG ++ + +LL +GA +
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
Query: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM----VRFL 420
+ G +PL A + + + L+ +GA +N + E T Y + + +L
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVN----DLDERGCTPLHYAATSDTDGKCLEYL 491
Query: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----------SGAQVNMPADSFE-- 468
L A+ + + + A+ + GH +L+ SG + +D+
Sbjct: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
Query: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
SPL LAA GH + +L++ L+ N G TPL AA +GH E V +L+ QGA+I
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Query: 529 QTEETQETALTLACCGGFLEVADFLI-----KAGADIELGCS-TPLMEAAQEGHLELVKY 582
+ + T + A G E LI + DI+ G TPLM + GH + V
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
Query: 583 LLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 642
LL GANV A G TAL GH + D LLQ GA GRTP+ +A GH
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 731
Query: 643 VCTVQFLISKGANVN---RTTANNDHTVLSLACAGGHLAVVELLL 684
+ + L+ A+++ T N+ +T L AC GH VELLL
Sbjct: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL 776
Score = 147 bits (370), Expect = 2e-34
Identities = 112/351 (31%), Positives = 174/351 (49%), Gaps = 7/351 (1%)
Query: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK 430
L++A G + R L+ +N NE K + L A Y G E++ L+ +GA K
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNE-KRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 431 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 490
+ T L A E ++LL A VN ++++PL +AA V+ A L+
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
Query: 491 ASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVA 550
+++ + G T L AA GH EMV LLL +GANINA ++ A+ A G +EV
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA-FDKKDRRAIHWAAYMGHIEVV 189
Query: 551 DFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACEN 607
L+ GA++ + TPL AA G + +VKYLL G +++ A G+T L AC N
Sbjct: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
Query: 608 GHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH-VCTVQFLISKGANVNRTTANNDHT 666
G V + L+ GA + ++E G TPL AA + H ++ L+ GA+VN + + T
Sbjct: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN-MKSKDGKT 308
Query: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
L + G + + ++ GA K+G+T L AA+ GH ++ L+
Sbjct: 309 PLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
Score = 146 bits (368), Expect = 3e-34
Identities = 110/353 (31%), Positives = 167/353 (47%), Gaps = 36/353 (10%)
Query: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145
+L A G + V+ L+ + + +D + TPL AA G ++E+L+ +GA + A+
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205
+ TPL A + +E V++LL A+ R+ + TPL +AA+ V + L+
Sbjct: 71 DSKWL-TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
Query: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265
+ +N + G + L AA +GH VKLLL G++INA + +R A+ A + G
Sbjct: 130 LSNVN--VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGHI 186
Query: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD---- 1321
EVV LL+ A V + K TPL AAS G V + LLD G D+N P +
Sbjct: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246
Query: 1322 ---------------------------TALTIAADKGHYKFC-ELLIGRGAHIDVRNKKG 1353
T L AA H C ELL+G GA +++++K G
Sbjct: 247 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDG 306
Query: 1354 NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
TPL + A G Q ++Q+GA +D D TPL A R GH ++ L+
Sbjct: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
Score = 145 bits (366), Expect = 5e-34
Identities = 116/373 (31%), Positives = 179/373 (47%), Gaps = 43/373 (11%)
Query: 1069 IYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH 1128
I+ D++ Q ++ T L A G E+++ L+ GA + +D K TPL A +
Sbjct: 28 IFKKEDVNFQ-DNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
Query: 1129 VGVVEILLDNGADIEAQ--------------------------------SERTKDTPLSL 1156
V++LL + AD+ A+ S+R T L
Sbjct: 87 EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
Query: 1157 ACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSK 1216
A G E+V+LLL+RGAN + D + AA G++ ++K+L++ GAE+ + K
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK--DK 204
Query: 1217 LGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKA 1276
+PL AA +G + VK LLD+G D+N + NT L +AC+ G+ VV+ L+D A
Sbjct: 205 KSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
Query: 1277 NVEHRAKTGLTPLMEAASGGYAEVG-RVLLDKGADVNAPPVPSSRD--TALTIAADKGHY 1333
V + + G TPL AA+ + + +L+ GADVN S+D T L + A G +
Sbjct: 264 IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNM----KSKDGKTPLHMTALHGRF 319
Query: 1334 KFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAA 1393
+ +I GA ID +K GNTPL +AA GH ++ L+ +GAD + PL A
Sbjct: 320 SRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLA 379
Query: 1394 FRKGHVKVVRYLV 1406
G R L+
Sbjct: 380 ALSGFSDCCRKLL 392
Score = 144 bits (363), Expect = 1e-33
Identities = 128/425 (30%), Positives = 195/425 (45%), Gaps = 13/425 (3%)
Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
D L+ A G V+ L+ K DVN Q + T L A G +++++L+ SGA +
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
+ TPL A ++ E ++LL++ A +N + ++ L +A ++ L
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNW-QTPLHIAAANKAVKCAEAL 126
Query: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
+ ++ TAL A GH E+ +LLL GA +N + AA GH+
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
Query: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
E+ LL+ GA + + + YTPL AA G +V LL G ++N + T L +
Sbjct: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHV 245
Query: 541 ACCGGFLEVADFLIKAGADI----ELGCSTPLMEAAQEGHLEL-VKYLLAAGANVHATTA 595
AC G V + LI GA + E G TPL AA H L ++ L+ GA+V+ +
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKG-FTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
Query: 596 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGAN 655
G T L +G + ++Q+GA ++ E + G TPL AAR GH + LI+ GA+
Sbjct: 305 DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
Query: 656 VNRTTANNDHTV--LSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
T H + L LA G LL+ G D G T L AA GG+ +
Sbjct: 365 ---TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECL 421
Query: 714 CYLLD 718
LL+
Sbjct: 422 NLLLN 426
Score = 144 bits (363), Expect = 1e-33
Identities = 135/462 (29%), Positives = 201/462 (43%), Gaps = 54/462 (11%)
Query: 293 VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352
+ D + I+PL AA GH + +++L+ D++ ++S+G T L A G+V+ V V
Sbjct: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601
Query: 353 LLESGASI--EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK--ESALTLA 408
L+ GASI +D+ TP+ A + GH E RLL+ N N + ++ L L+
Sbjct: 602 LINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
Query: 409 CYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 468
GH + V LL GA+ + K TAL + GH E LL GA+ +
Sbjct: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
Query: 469 SPLTLAACGGHVELAALLIERGASLEE----VNDEGYTPLMEAAREGHEEMVALLLGQGA 524
+P+ L+A GH+ + L++ AS++ ++ GYT L A GHE V LLL Q
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ-- 778
Query: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLL 584
+ +TE + L A A+ LI LG S
Sbjct: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDT-----LGASI------------------ 815
Query: 585 AAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644
V+AT + G T L A H + +LL A + G+TPLM AA G
Sbjct: 816 -----VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTN 870
Query: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGAD-------------PT 691
TV+ L+S + N+ +T L LAC+ GH L+L D P
Sbjct: 871 TVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPL 930
Query: 692 H-RLKDGSTMLIEAAKGGHTSVVCYLLD-YPNNLLSAPPPDV 731
H ++G TM+++ G SV+ + Y L AP DV
Sbjct: 931 HVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDV 972
Score = 137 bits (344), Expect = 2e-31
Identities = 143/526 (27%), Positives = 232/526 (44%), Gaps = 64/526 (12%)
Query: 935 VLLKDEPQQTAAQMGF-APIQPLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQA 993
VLLK A + P+ A +A+ A +P S N+++ G+ L A
Sbjct: 92 VLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDR----AGRTALHHA 147
Query: 994 QLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQ 1053
+G G+ + +G + A D AA G + +H + +
Sbjct: 148 AFSGHGEMVKLLLSRGANIN--AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK 205
Query: 1054 TPTPSPIISPSAMLPIYPAIDIDAQTESNH-----DTALTLACAGGHEELVQTLLERGAS 1108
+ TP + S M+ + + +D + N +T L +AC G + +V L++ GA
Sbjct: 206 SYTPLHAAASSGMISVVKYL-LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAI 264
Query: 1109 IEHRDKKGFTPLILAATAGHVGV-VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVE 1167
+ +++KGFTPL AA + H + +E+L+ NGAD+ +S+ K TPL + GR +
Sbjct: 265 VNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQ 323
Query: 1168 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1227
++ GA + + + TPL +AA G+ +I L+ +GA+ R G+ PL LAA+
Sbjct: 324 TIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKR--GIHGMFPLHLAAL 381
Query: 1228 NGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLT 1287
+G + + LL G DI+ + R T L A G E ++LLL+ A+ + K G +
Sbjct: 382 SGFSDCCRKLLSSGFDIDTPDDFGR-TCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRS 440
Query: 1288 PLMEAASGGYAEVGRVLLDKGADVN------APPV----------------------PSS 1319
PL AA+ + L+ GA VN P+ P
Sbjct: 441 PLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGI 500
Query: 1320 RD----TALTIAADKGHYKFCELLIGRGAHIDV-------------RNKKGNTPLWLAAN 1362
RD A+ +A GH + C LI +DV N+ +PL LAA
Sbjct: 501 RDKQGYNAVHYSAAYGH-RLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAY 559
Query: 1363 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
GH +++LVQ+ D+D ++ TPL A KGHV+ V L+ +
Sbjct: 560 HGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQ 605
Score = 129 bits (324), Expect = 4e-29
Identities = 106/329 (32%), Positives = 155/329 (47%), Gaps = 16/329 (4%)
Query: 1072 AIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 1131
A+DI + N T L L+ GH + V +LL +GA+++ +DK G T L A GH
Sbjct: 645 AVDIQ---DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEEC 701
Query: 1132 VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL----ARGANKEHRNVSDYTPL 1187
V+ LL +GA + R + TP+ L+ + G V+ LL + AN + YT L
Sbjct: 702 VDALLQHGAKCLLRDSRGR-TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTAL 760
Query: 1188 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD-MGSDINA 1246
A G+ +++LL E+ +T SPL A +N + A ++L+D +G+ I
Sbjct: 761 HWACYNGHETCVELLLE--QEVFQKTEGN-AFSPLHCAVINDNEGAAEMLIDTLGASIVN 817
Query: 1247 QIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1306
++ T L A F E + LLL A V TG TPLM AA G +L+
Sbjct: 818 ATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV- 876
Query: 1307 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH---IDVRNKKGNTPLWLAANG 1363
A +S++TAL +A KGH L++ + I+ N TPL +AA
Sbjct: 877 SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARN 936
Query: 1364 GHLDVVQLLVQAGADVDAADNRKITPLMA 1392
G VVQ L+ GA V A D TP +A
Sbjct: 937 GLTMVVQELLGKGASVLAVDENGYTPALA 965
Score = 124 bits (312), Expect = 9e-28
Identities = 104/352 (29%), Positives = 160/352 (45%), Gaps = 43/352 (12%)
Query: 1087 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 1146
L LA GH + ++ L++ ++ R+ G TPL LAA GHV V++L++ GA I +
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
Query: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1203
K TP+ A + G E + LL+ + ++ D TPL L+ G+ + + LL
Sbjct: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673
Query: 1204 NAGAEINSRT-------------------------GSKL------GISPLMLAAMNGHTA 1232
N GA ++++ G+K G +P+ L+A GH
Sbjct: 674 NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIG 733
Query: 1233 AVKLLLDMGSDINAQIETNRN---TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPL 1289
+ LL + ++A T N TAL AC+ G V LLL+++ + +PL
Sbjct: 734 VLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPL 792
Query: 1290 MEAASGGYAEVGRVLLDK-GAD-VNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHID 1347
A +L+D GA VNA S T L AA H + +LL+ A ++
Sbjct: 793 HCAVINDNEGAAEMLIDTLGASIVNA--TDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850
Query: 1348 VRNKKGNTPLWLAANGGHLDVVQLLV-QAGADVDAADNRKITPLMAAFRKGH 1398
+ G TPL +AA G + V++LV A A++ DN K T L A KGH
Sbjct: 851 SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH 902
Score = 109 bits (273), Expect = 3e-23
Identities = 91/296 (30%), Positives = 145/296 (48%), Gaps = 10/296 (3%)
Query: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
TAL GHEE V LL+ GA RD +G TP+ L+A GH+GV+ LL + A ++A
Sbjct: 688 TALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDA 747
Query: 1145 QSERTKD---TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1201
+ T L AC G + VELLL + ++ + ++PL A ++
Sbjct: 748 NPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVINDNEGAAEM 806
Query: 1202 LLNA-GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1260
L++ GA I + T SK G +PL AA H ++LLL + +N+ +++ T L +A
Sbjct: 807 LIDTLGASIVNATDSK-GRTPLHAAAFTDHVECLQLLLSHNAQVNS-VDSTGKTPLMMAA 864
Query: 1261 FQGRTEVVSLLL-DRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN-APPVPS 1318
G+T V +L+ A + + + T L A S G+ ++L+K D N +
Sbjct: 865 ENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNA 924
Query: 1319 SRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTP-LWLAANGGHLDVVQLLV 1373
+ T L +AA G + L+G+GA + ++ G TP L A N D + L++
Sbjct: 925 ALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980
Score = 95.9 bits (237), Expect = 5e-19
Identities = 74/224 (33%), Positives = 113/224 (50%), Gaps = 5/224 (2%)
Query: 1183 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS 1242
D L A G + ++ L+ ++N + K +PL AA G ++LL+ G+
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKR--TPLHAAAYLGDAEIIELLILSGA 65
Query: 1243 DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1302
+NA+ ++ T L A E V +LL A+V R K TPL AA+ +
Sbjct: 66 RVNAK-DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAE 124
Query: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362
L+ ++VN + TAL AA GH + +LL+ RGA+I+ +KK + AA
Sbjct: 125 ALVPLLSNVNVSD--RAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAY 182
Query: 1363 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
GH++VV+LLV GA+V D + TPL AA G + VV+YL+
Sbjct: 183 MGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL 226
Score = 72.8 bits (177), Expect = 4e-12
Identities = 68/277 (24%), Positives = 112/277 (40%), Gaps = 40/277 (14%)
Query: 238 LAEACSEGDVNAVRKLLIEGRSVNEHT----EEGESLLCLACSAGYYELAQVLLAMHANV 293
L+ AC G + + LL S++ + G + L AC G+ ++LL
Sbjct: 725 LSAAC--GHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQ 782
Query: 294 EDRGIKGDITPLMAAANGGHVKIVKLLL--AHKADVNAQSSTGNTALTYACAGGYVDVVK 351
+ G +PL A + ++L+ + VNA S G T L A +V+ ++
Sbjct: 783 KTEG--NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ 840
Query: 352 VLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYK 411
+LL A + + G TPLM A G +L+ + + T + K +AL LAC K
Sbjct: 841 LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900
Query: 412 GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 471
GH +LE D+ +N + ++PL
Sbjct: 901 GHETSALLILEKITDRN------------------------------LINATNAALQTPL 930
Query: 472 TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
+AA G + L+ +GAS+ V++ GYTP + A
Sbjct: 931 HVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
Score = 69.3 bits (168), Expect = 5e-11
Identities = 48/157 (30%), Positives = 75/157 (47%), Gaps = 5/157 (3%)
Query: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
T+S T L A H E +Q LL A + D G TPL++AA G VE+L+ +
Sbjct: 819 TDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSS 878
Query: 1139 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD---YTPLSLAASGGY 1195
+ + +K+T L LACS G + L+L + ++ N ++ TPL +AA G
Sbjct: 879 ASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGL 938
Query: 1196 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTA 1232
+++ LL GA + + G +P + A N A
Sbjct: 939 TMVVQELLGKGASV--LAVDENGYTPALACAPNKDVA 973
Score = 42.4 bits (98), Expect = 0.006
Identities = 32/122 (26%), Positives = 60/122 (49%), Gaps = 3/122 (2%)
Query: 1339 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1398
LI + ++ ++ + TPL AA G ++++LL+ +GA V+A D++ +TPL A
Sbjct: 27 LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
Query: 1399 VKVVRYLVK---EVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKN 1455
+ V+ L+K +VN + + +IA + + + S V DR A +
Sbjct: 87 EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
Query: 1456 AS 1457
A+
Sbjct: 147 AA 148
Score = 42.0 bits (97), Expect = 0.008
Identities = 43/166 (25%), Positives = 72/166 (43%), Gaps = 1/166 (0%)
Query: 558 ADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL 617
A ++L L++A G + V+ L+ +V+ T L A G ++ ++L+
Sbjct: 2 AFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI 61
Query: 618 QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677
+GA + + TPL +A + VQ L+ A+VN N T L +A A +
Sbjct: 62 LSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN-ARDKNWQTPLHIAAANKAV 120
Query: 678 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNL 723
E L+ ++ + G T L AA GH +V LL N+
Sbjct: 121 KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI 166
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 164 bits (414), Expect = 1e-39
Identities = 169/572 (29%), Positives = 245/572 (42%), Gaps = 80/572 (13%)
Query: 224 AESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGY--YE 281
A + A A + R L EAC GDV V++ L+ VN G L +AG+ +
Sbjct: 14 ASAAAEAVEPAARELFEACRNGDVERVKR-LVTPEKVNSRDTAGRKSTPLHFAAGFGRKD 72
Query: 282 LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
+ + LL ANV+ R G + PL A + GH ++V LLL H AD NA+ + T L A
Sbjct: 73 VVEYLLQNGANVQARD-DGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEA 131
Query: 342 CAGGYVDVVKVLLESGASIEDHNENGHT--------------------PLMEAGSAGHVE 381
G +DV VLL+ GA N +G T L+E+ +G+ E
Sbjct: 132 AIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEE 191
Query: 382 VARLLLENGAGINTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
LL +N H+++ ++S L LA +++V+ LL+ GAD K L
Sbjct: 192 KMMALL-TPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHN 250
Query: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN--- 497
AC GH EV LL+ GA VN +PL AA VE+ +LL+ GA +N
Sbjct: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310
Query: 498 ----DEGYTP--------------LMEAAREGHEEMVALLLGQGANINAQTEETQETALT 539
D TP L++AARE + L +N + +T ETAL
Sbjct: 311 KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSL-EMVNFKHPQTHETALH 369
Query: 540 LACCGGF---LEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHAT 593
A + ++ + L++ GA+I TPL A+++ H ++V+ ++ A V+A
Sbjct: 370 CAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNAL 429
Query: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRT--------------------- 632
G T+L A GH +LL G D S G T
Sbjct: 430 DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGN 489
Query: 633 -----PLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687
L++AA+AG V TV+ L + + R T L A ++VVE LL HG
Sbjct: 490 SEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG 549
Query: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
AD + K G L A GH V L+ +
Sbjct: 550 ADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581
Score = 156 bits (394), Expect = 3e-37
Identities = 168/561 (29%), Positives = 244/561 (43%), Gaps = 76/561 (13%)
Query: 209 SCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
+C+ A +R + NA + N + L EA +G ++ LL G +G
Sbjct: 98 ACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDG 157
Query: 268 ESLLCLACSA------GYYELAQVLLAMHANVEDR----------------GIKGDITPL 305
+ L LA + G Y+ ++L + + E++ G K TPL
Sbjct: 158 RTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKS--TPL 215
Query: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
AA VKIV+LLL H ADV+A+ L AC+ G+ +V ++L++ GA + +
Sbjct: 216 HLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDL 275
Query: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLAC-----------YKGH- 413
TPL EA S VEV LLL GA T N +SA+ LA +KGH
Sbjct: 276 WQFTPLHEAASKNRVEVCSLLLSYGAD-PTLLNCHNKSAIDLAPTPQLKERLAYEFKGHS 334
Query: 414 ------------------LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 455
LEMV F Q H+T +H A ++ LLL
Sbjct: 335 LLQAAREADVTRIKKHLSLEMVNF----KHPQTHET-ALHCAAASP-YPKRKQICELLLR 388
Query: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515
GA +N F +PL +A+ H ++ ++++ A + +++ G T L AA GH +
Sbjct: 389 KGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQT 448
Query: 516 VALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAA 572
LLL G + N + + TAL + E L++ G I LG S L+EAA
Sbjct: 449 CRLLLSYGCDPNIISLQ-GFTALQMG-----NENVQQLLQEG--ISLGNSEADRQLLEAA 500
Query: 573 QEGHLELVKYLLAA-GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 631
+ G +E VK L N T L +A V + LLQ GAD+ + +GG
Sbjct: 501 KAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGL 560
Query: 632 TPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPT 691
PL A GH + L+ GA VN T L A A G + +LLL HGADPT
Sbjct: 561 VPLHNACSYGHYEVAELLVKHGAVVNVADLWK-FTPLHEAAAKGKYEICKLLLQHGADPT 619
Query: 692 HRLKDGSTMLIEAAKGGHTSV 712
+ +DG+T L + K G T +
Sbjct: 620 KKNRDGNTPL-DLVKDGDTDI 639
Score = 154 bits (389), Expect = 1e-36
Identities = 181/699 (25%), Positives = 295/699 (42%), Gaps = 119/699 (17%)
Query: 196 ADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLI 255
ADP +L S A+D A + R A + SL +A E DV ++K L
Sbjct: 301 ADPTLLNCHNKS---AIDLAPTPQLKERL-----AYEFKGHSLLQAAREADVTRIKKHLS 352
Query: 256 EGRSVNEHTEEGESLLCLACSAGY---YELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
+H + E+ L A ++ Y ++ ++LL AN+ ++ K +TPL A+
Sbjct: 353 LEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEK-TKEFLTPLHVASEKA 411
Query: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGA-----------SIE 361
H +V++++ H+A VNA + G T+L A G++ ++LL G +++
Sbjct: 412 HNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQ 471
Query: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAG--------------INTHSNEFKESA-LT 406
NEN L E S G+ E R LLE +N E ++S L
Sbjct: 472 MGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLH 531
Query: 407 LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466
A + +V +LL+ GAD K L AC GH EVA LL+ GA VN+ AD
Sbjct: 532 FAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV-ADL 590
Query: 467 FE-SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGAN 525
++ +PL AA G E+ LL++ GA + N +G TPL + ++G ++ LL G A
Sbjct: 591 WKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRGDAAL 649
Query: 526 INAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLA 585
++A + C +++ D + STPL AA +LE+ +YLL
Sbjct: 650 LDAAKK---------GCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQ 700
Query: 586 AGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCT 645
GA+V+A G L A GH DVA +L++ A + + TPL +AA+ G
Sbjct: 701 HGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGR--- 757
Query: 646 VQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 705
+ CA LLLAHGADPT + ++G T
Sbjct: 758 -----------------------TQLCA--------LLLAHGADPTLKNQEGQT------ 780
Query: 706 KGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPD--K 763
P +L+SA DV+ L + +P ALP PQ + +
Sbjct: 781 --------------PLDLVSA--DDVSALLTAA--------MPPSALPSCYKPQVLNGVR 816
Query: 764 PPANVATTL---PIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQ 820
P A L P + S S +L + ++ +++ E + ++ ++
Sbjct: 817 SPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDF 876
Query: 821 RIKEAIEKNAQLQSLELAHADQLTKEKIEELNKTREEQI 859
I + + +++ +Q+T + + E+ ++I
Sbjct: 877 SITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEI 915
Score = 130 bits (327), Expect = 2e-29
Identities = 219/841 (26%), Positives = 332/841 (39%), Gaps = 132/841 (15%)
Query: 504 LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL- 562
L EA R G E V L+ + T + T L A G +V ++L++ GA+++
Sbjct: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
Query: 563 --GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
G PL A GH E+V LL GA+ +A T L A G DV VLLQ G
Sbjct: 88 DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 147
Query: 621 ADLEHESEGGRTPL--------------------MKAARAGHVCTVQFLISKGANVN-RT 659
A+ + GRT L +++AR+G+ + L++ NVN
Sbjct: 148 AEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHA 206
Query: 660 TANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
+ T L LA + +V+LLL HGAD + K L A GH V L+ +
Sbjct: 207 SDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKH 266
Query: 720 PNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAA 779
D+ Q T P H+ RV V +L ++ +P T L NK+A
Sbjct: 267 G---ACVNAMDLWQFT-PLHEAASKNRVEVCSL-LLSYGADP--------TLLNCHNKSA 313
Query: 780 SKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEA----IEKNAQLQSL 835
+ T Q E + E +G L Q +EA I+K+ L+ +
Sbjct: 314 ---------------IDLAPTPQLKERLAYEFKGH--SLLQAAREADVTRIKKHLSLEMV 356
Query: 836 ELAHADQLTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQR 895
H T E L+ K+++I E L + + KT++
Sbjct: 357 NFKHPQ--THE--TALHCAAASPYPKRKQICELLLRKGANINEKTKE------------- 399
Query: 896 IQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAA-QMGFAPIQ 954
LTP+ V + + D V V++K E + A +G +
Sbjct: 400 ---------------FLTPLHVASEKAHND------VVEVVVKHEAKVNALDNLGQTSLH 438
Query: 955 PLAMPQALPLAAGPLPPGSIANLTELQG---VIVGQPVLGQAQLAGLGQGILTETQQGLM 1011
A L L G N+ LQG + +G + Q G+ G +E + L+
Sbjct: 439 RAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLG-NSEADRQLL 497
Query: 1012 VASPAQTLNDT--LDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPI 1069
A+ A + L + + +TP H AA ++ +S L +
Sbjct: 498 EAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLH-FAAGYNR---------VSVVEYL-L 546
Query: 1070 YPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHV 1129
D+ A+ + L AC+ GH E+ + L++ GA + D FTPL AA G
Sbjct: 547 QHGADVHAKDKGGL-VPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKY 605
Query: 1130 GVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 1189
+ ++LL +GAD + R +TPL L G ++ +LL RG D L
Sbjct: 606 EICKLLLQHGAD-PTKKNRDGNTPLDLV-KDGDTDIQDLL--RG---------DAALLDA 652
Query: 1190 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE 1249
A G + K L++ +N R +PL LAA + + LL G+D+NAQ +
Sbjct: 653 AKKGCLARVKK--LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQ-D 709
Query: 1250 TNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1309
L A G +V +LL+ A V K TPL EAA G ++ +LL GA
Sbjct: 710 KGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 769
Query: 1310 D 1310
D
Sbjct: 770 D 770
Score = 124 bits (312), Expect = 9e-28
Identities = 120/404 (29%), Positives = 171/404 (42%), Gaps = 80/404 (19%)
Query: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
T T L A G +++V+ LL+ GA+++ RD G PL A + GH VV +LL +
Sbjct: 54 TAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRH 113
Query: 1139 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL--------- 1189
GAD A+ + TPL A G+ +V +LL GA RN T L L
Sbjct: 114 GADPNAR-DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVL 172
Query: 1190 ------------AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 1237
A SG ++ +L ++ G K +PL LAA V+LL
Sbjct: 173 TGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRK--STPLHLAAGYNRVKIVQLL 230
Query: 1238 LDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY 1297
L G+D++A+ + L AC G EV LL+ A V TPL EAAS
Sbjct: 231 LQHGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNR 289
Query: 1298 AEVGRVLLDKGAD-----------VNAPPVP----------------------------- 1317
EV +LL GAD ++ P P
Sbjct: 290 VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKK 349
Query: 1318 ------------SSRDTALTIAADKGHYK---FCELLIGRGAHIDVRNKKGNTPLWLAAN 1362
+ +TAL AA + K CELL+ +GA+I+ + K+ TPL +A+
Sbjct: 350 HLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASE 409
Query: 1363 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
H DVV+++V+ A V+A DN T L A GH++ R L+
Sbjct: 410 KAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLL 453
Score = 119 bits (299), Expect = 3e-26
Identities = 111/382 (29%), Positives = 164/382 (42%), Gaps = 69/382 (18%)
Query: 1083 HDTALTLACAGGH---EELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139
H+TAL A A + +++ + LL +GA+I + K+ TPL +A+ H VVE+++ +
Sbjct: 364 HETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHE 423
Query: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199
A + A + T L A G + LLL+ G + ++ +T L + +
Sbjct: 424 AKVNAL-DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----V 477
Query: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1259
+ LL G + + + L+ AA G VK L + S IE ++T L A
Sbjct: 478 QQLLQEGISLGNSEADR----QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFA 533
Query: 1260 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1319
R VV LL A+V + K GL PL A S G+ EV +L+ GA VN +
Sbjct: 534 AGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADL--W 591
Query: 1320 RDTALTIAADKGHYKFCELLIGRGAHIDVRN----------------------------- 1350
+ T L AA KG Y+ C+LL+ GA +N
Sbjct: 592 KFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLD 651
Query: 1351 --KKG-----------------------NTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1385
KKG +TPL LAA +L+V + L+Q GADV+A D
Sbjct: 652 AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711
Query: 1386 KITPLMAAFRKGHVKVVRYLVK 1407
+ PL A GHV V L+K
Sbjct: 712 GLIPLHNAASYGHVDVAALLIK 733
Score = 118 bits (295), Expect = 9e-26
Identities = 99/296 (33%), Positives = 136/296 (45%), Gaps = 21/296 (7%)
Query: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139
E T L A +V+ LL+ GA + +DK G PL A + GH V E+L+ +G
Sbjct: 523 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582
Query: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199
A + ++ K TPL A + G+ E+ +LLL GA+ +N TPL L G I
Sbjct: 583 AVVNV-ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGD--TDI 639
Query: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1259
+ LL G + L+ AA G A VK L + + +T L LA
Sbjct: 640 QDLLR-------------GDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLA 686
Query: 1260 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1319
EV LL A+V + K GL PL AAS G+ +V +L+ A VNA
Sbjct: 687 AGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA--TDKW 744
Query: 1320 RDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1375
T L AA KG + C LL+ GA ++N++G TPL L + DV LL A
Sbjct: 745 AFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD---DVSALLTAA 797
Score = 109 bits (273), Expect = 3e-23
Identities = 103/374 (27%), Positives = 158/374 (42%), Gaps = 67/374 (17%)
Query: 1090 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD-------- 1141
AC+ GH E+ + L++ GA + D FTPL AA+ V V +LL GAD
Sbjct: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310
Query: 1142 ---------------------------------------------IEAQSERTKDTPLSL 1156
+ + +T +T L
Sbjct: 311 KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHC 370
Query: 1157 ACSGG---RQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1213
A + R+++ ELLL +GAN + TPL +A+ + +++++++ A++N+
Sbjct: 371 AAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNAL- 429
Query: 1214 GSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLD 1273
LG + L AA GH +LLL G D N I TAL + G V LL +
Sbjct: 430 -DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI-ISLQGFTALQM----GNENVQQLLQE 483
Query: 1274 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1333
+ A L+EAA G E + L + VN + + T L AA
Sbjct: 484 GISLGNSEADR---QLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRV 539
Query: 1334 KFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAA 1393
E L+ GA + ++K G PL A + GH +V +LLV+ GA V+ AD K TPL A
Sbjct: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599
Query: 1394 FRKGHVKVVRYLVK 1407
KG ++ + L++
Sbjct: 600 AAKGKYEICKLLLQ 613
Score = 106 bits (264), Expect = 3e-22
Identities = 114/375 (30%), Positives = 161/375 (42%), Gaps = 28/375 (7%)
Query: 1150 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 1209
K TPL A GR++VVE LL GAN + R+ PL A S G+ ++ +LL GA+
Sbjct: 58 KSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADP 117
Query: 1210 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS 1269
N+R +PL AA+ G +LL G++ T RNT GRT +
Sbjct: 118 NAR--DNWNYTPLHEAAIKGKIDVCIVLLQHGAE-----PTIRNT-------DGRTALD- 162
Query: 1270 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1329
L D A + L+E+A G E LL +VN + T L +AA
Sbjct: 163 -LADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAG 220
Query: 1330 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP 1389
K +LL+ GA + ++K PL A + GH +V +LLV+ GA V+A D + TP
Sbjct: 221 YNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTP 280
Query: 1390 LMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCME----SIVQ-A 1444
L A K V+V L+ P+ C A K L E S++Q A
Sbjct: 281 LHEAASKNRVEVCSLLL-SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAA 339
Query: 1445 KDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEA 1504
++ K+ S+ + + E + A A+ KRK+ E RK I
Sbjct: 340 READVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ----ICELLLRKGANINE 395
Query: 1505 KNKENF-ELQAAQEK 1518
K KE L A EK
Sbjct: 396 KTKEFLTPLHVASEK 410
Score = 98.2 bits (243), Expect = 9e-20
Identities = 96/315 (30%), Positives = 138/315 (43%), Gaps = 16/315 (5%)
Query: 191 DGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAV 250
+G + + E R+L + E L +++ + + + L A V+ V
Sbjct: 483 EGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVV 542
Query: 251 RKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAAN 310
LL G V+ + G L ACS G+YE+A+ LL H V + TPL AA
Sbjct: 543 EYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE-LLVKHGAVVNVADLWKFTPLHEAAA 601
Query: 311 GGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
G +I KLLL H AD ++ GNT L D+VK + I+D G
Sbjct: 602 KGKYEICKLLLQHGADPTKKNRDGNTPL---------DLVK---DGDTDIQD-LLRGDAA 648
Query: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEH 429
L++A G + + L + +N + + S L LA +LE+ +LL+ GAD
Sbjct: 649 LLDAAKKGCLARVK-KLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707
Query: 430 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
+ L A GHV+VA LL+ A VN +PL AA G +L ALL+
Sbjct: 708 QDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAH 767
Query: 490 GASLEEVNDEGYTPL 504
GA N EG TPL
Sbjct: 768 GADPTLKNQEGQTPL 782
Score = 97.1 bits (240), Expect = 2e-19
Identities = 107/314 (34%), Positives = 135/314 (42%), Gaps = 25/314 (7%)
Query: 1081 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKG--FTPLILAATAGHVGVVEILLDN 1138
S D L A G E V+ L S+ RD +G TPL AA V VVE LL +
Sbjct: 490 SEADRQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548
Query: 1139 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNI 1198
GAD+ A+ ++ PL ACS G EV ELL+ GA ++ +TPL AA+ G I
Sbjct: 549 GADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607
Query: 1199 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL 1258
K+LL GA+ + ++ G +PL L D + Q + AL
Sbjct: 608 CKLLLQHGADPTKK--NRDGNTPLDLVK--------------DGDTDIQDLLRGDAALLD 651
Query: 1259 ACFQGRTEVVSLLLDRKANVEHRAKTGL--TPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316
A +G V L NV R G TPL AA EV LL GADVNA
Sbjct: 652 AAKKGCLARVKKL-SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDK 710
Query: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376
L AA GH LLI A ++ +K TPL AA G + LL+ G
Sbjct: 711 GGL--IPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 768
Query: 1377 ADVDAADNRKITPL 1390
AD + TPL
Sbjct: 769 ADPTLKNQEGQTPL 782
Score = 80.5 bits (197), Expect = 2e-14
Identities = 70/211 (33%), Positives = 92/211 (43%), Gaps = 31/211 (14%)
Query: 1222 LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHR 1281
L A NG VK L+ + ++T L A GR +VV LL ANV+ R
Sbjct: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
Query: 1282 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCE 1337
GL PL A S G+AEV +LL GAD P++RD T L AA KG C
Sbjct: 88 DDGGLIPLHNACSFGHAEVVNLLLRHGAD------PNARDNWNYTPLHEAAIKGKIDVCI 141
Query: 1338 LLIGRGAHIDVRNKKGNTPLWL---------------------AANGGHLDVVQLLVQAG 1376
+L+ GA +RN G T L L A +G ++ LL
Sbjct: 142 VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201
Query: 1377 ADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
+ A+D RK TPL A VK+V+ L++
Sbjct: 202 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQ 232
Score = 70.5 bits (171), Expect = 2e-11
Identities = 42/114 (36%), Positives = 62/114 (54%), Gaps = 1/114 (0%)
Query: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
T+ H T L LA + E+ + LL+ GA + +DK G PL AA+ GHV V +L+
Sbjct: 675 TQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKY 734
Query: 1139 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 1192
A + A +++ TPL A GR ++ LLLA GA+ +N TPL L ++
Sbjct: 735 NACVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 160 bits (406), Expect = 1e-38
Identities = 132/382 (34%), Positives = 177/382 (46%), Gaps = 6/382 (1%)
Query: 278 GYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTA 337
G E ++LLA +V+ + G TPL+ AA + LLLAH AD N G
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASG-YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431
Query: 338 LTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 397
L +A G ++LL+ GA ++ G TPL A VARLL+ A N H
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491
Query: 398 NEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 457
E K + L +A Y GH+ +V+ L GA+ + + + T L A G V + LL SG
Sbjct: 492 AEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
Query: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517
A + S PL AA G + +L+ GASLE +G+TPL AA +GH E++
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
Query: 518 LLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD---IELGCSTPLMEAAQE 574
LL AN+ A T L LA G V L++ GAD E TPL A Q
Sbjct: 611 LLAESHANMGA-LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669
Query: 575 GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 634
V LL ANVHA G T A G+T + VL++AGA L+ + TPL
Sbjct: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729
Query: 635 MKAARAGHVCTVQFLISKGANV 656
A R+ + FL K +V
Sbjct: 730 QLALRSRKQGIMSFLEGKEPSV 751
Score = 151 bits (382), Expect = 7e-36
Identities = 120/365 (32%), Positives = 172/365 (47%), Gaps = 38/365 (10%)
Query: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132
+D+D QT S + T L +A +L LL GA D+ G+ PL AA G G
Sbjct: 386 VDVDCQTASGY-TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTA 444
Query: 1133 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 1192
+LLD+GA ++AQ ER TPL LA + V LL++R A+ TPL +AA
Sbjct: 445 RLLLDHGACVDAQ-EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAY 503
Query: 1193 GGYVNIIKILLNAGAEI-----NSRTGSKL--------------------------GISP 1221
G+V+++K+L + GAE+ N RT L G P
Sbjct: 504 FGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP 563
Query: 1222 LMLAAMNGHTAAVKLLLDMGSDINAQIETNRN-TALTLACFQGRTEVVSLLLDRKANVEH 1280
L AA G K+LL G+ + ++ T++ T L LA ++G E++ LL + AN+
Sbjct: 564 LHTAAARGKYLICKMLLRYGASL--ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA 621
Query: 1281 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1340
TPL AA G V LL GAD NA S T L +A + + L+
Sbjct: 622 LGAVNWTPLHLAARHGEEAVVSALLQCGADPNA--AEQSGWTPLHLAVQRSTFLSVINLL 679
Query: 1341 GRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVK 1400
A++ RNK G TP LAA G+ ++++LV+AGA +D D TPL A R
Sbjct: 680 EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQG 739
Query: 1401 VVRYL 1405
++ +L
Sbjct: 740 IMSFL 744
Score = 135 bits (340), Expect = 5e-31
Identities = 108/330 (32%), Positives = 157/330 (47%), Gaps = 7/330 (2%)
Query: 1082 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 1141
N T L A G E V+ LL ++ + G+TPL++AA + +LL +GAD
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1201
E PL A G LLL GA + + +TPL LAA + N+ ++
Sbjct: 421 ANRVDE-DGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 1202 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACF 1261
L++ A+ N G +PL +AA GH + VKLL G++++AQ + N T L LA
Sbjct: 480 LVSRQADPNLHEAE--GKTPLHVAAYFGHVSLVKLLTSQGAELDAQ-QRNLRTPLHLAVE 536
Query: 1262 QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1321
+G+ + LL A + ++G PL AA+ G + ++LL GA + P
Sbjct: 537 RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP--THQGW 594
Query: 1322 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1381
T L +AA KGH + LL A++ TPL LAA G VV L+Q GAD +A
Sbjct: 595 TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654
Query: 1382 ADNRKITPL-MAAFRKGHVKVVRYLVKEVN 1410
A+ TPL +A R + V+ L N
Sbjct: 655 AEQSGWTPLHLAVQRSTFLSVINLLEHHAN 684
Score = 128 bits (321), Expect = 8e-29
Identities = 114/368 (30%), Positives = 169/368 (45%), Gaps = 11/368 (2%)
Query: 364 NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF-----KESALTLACYKGHLEMVR 418
NE+ LM++ S +++ A L L + + E K + L +G +E VR
Sbjct: 321 NEDISQELMDSDSGNYLKRA-LQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVR 379
Query: 419 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 478
LL D + +T +T L+ A D ++ LLL GA N + +PL AA G
Sbjct: 380 LLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNG 439
Query: 479 HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538
A LL++ GA ++ EG+TPL AA+ E + LL+ + A+ N E +T L
Sbjct: 440 DDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH-EAEGKTPL 498
Query: 539 TLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTA 595
+A G + + L GA+++ TPL A + G + +++LL +GA A
Sbjct: 499 HVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQ 558
Query: 596 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGAN 655
+G L A G + +LL+ GA LE + G TPL AA GH+ + L AN
Sbjct: 559 SGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHAN 618
Query: 656 VNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCY 715
+ A N T L LA G AVV LL GADP + G T L A + V
Sbjct: 619 MGALGAVN-WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN 677
Query: 716 LLDYPNNL 723
LL++ N+
Sbjct: 678 LLEHHANV 685
Score = 124 bits (310), Expect = 2e-27
Identities = 116/357 (32%), Positives = 161/357 (45%), Gaps = 6/357 (1%)
Query: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
EN TPL + G VE RLLL + ++ + + L +A ++ LL G
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTAS-GYTPLLIAAQDQQPDLCALLLAHG 418
Query: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484
AD ++ L A +G ARLLLD GA V+ +PL LAA +A
Sbjct: 419 ADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVAR 478
Query: 485 LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
LL+ R A EG TPL AA GH +V LL QGA ++AQ + T L LA
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQ-QRNLRTPLHLAVER 537
Query: 545 GFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601
G + L+K+GA ++ PL AA G + K LL GA++ T G T L
Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597
Query: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661
A GH ++ +L ++ A++ TPL AAR G V L+ GA+ N
Sbjct: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN-AAE 656
Query: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
+ T L LA V LL H A+ R K G T AA G+T+++ L++
Sbjct: 657 QSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVE 713
Score = 120 bits (301), Expect = 2e-26
Identities = 92/289 (31%), Positives = 141/289 (48%), Gaps = 2/289 (0%)
Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
A GD R LL G V+ EG + L LA + +A++L++ A+ +G
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494
Query: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
TPL AA GHV +VKLL + A+++AQ T L A G V ++ LL+SGA
Sbjct: 495 K-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
Query: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
+ +++G+ PL A + G + ++LL GA + +++ + L LA YKGHLE++ L
Sbjct: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ-GWTPLHLAAYKGHLEIIHLL 612
Query: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
E+ A+ T L A G V LL GA N S +PL LA
Sbjct: 613 AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTF 672
Query: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529
L+E A++ N G+TP AA +G+ ++ +L+ GA ++ Q
Sbjct: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
Score = 78.2 bits (191), Expect = 1e-13
Identities = 57/173 (32%), Positives = 82/173 (47%), Gaps = 2/173 (1%)
Query: 1248 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1307
I N+ T L QG E V LLL + +V+ + +G TPL+ AA ++ +LL
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
Query: 1308 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD 1367
GAD N V L AA G LL+ GA +D + ++G TPL LAA +
Sbjct: 418 GADANR--VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475
Query: 1368 VVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMR 1420
V +LLV AD + + TPL A GHV +V+ L + + + +R
Sbjct: 476 VARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR 528
Score = 52.8 bits (125), Expect = 4e-06
Identities = 41/134 (30%), Positives = 64/134 (47%), Gaps = 1/134 (0%)
Query: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
T L LA G E +V LL+ GA ++ G+TPL LA V LL++ A++ A
Sbjct: 628 TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687
Query: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204
++ + TP LA G ++++L+ GA + ++ TPL LA I+ L
Sbjct: 688 RN-KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746
Query: 1205 AGAEINSRTGSKLG 1218
+ + GSK G
Sbjct: 747 KEPSVATLGGSKPG 760
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 160 bits (406), Expect = 1e-38
Identities = 157/563 (27%), Positives = 250/563 (44%), Gaps = 32/563 (5%)
Query: 185 GKLSTADGKAFAD-PEVLRRLTSSVSCALDEAAAALTRM-RAESTANAGQSDNRSLAEAC 242
G+ G + D P+ S+ + +A L + + D L A
Sbjct: 12 GEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAA 71
Query: 243 SEGDVNAVRKLLIEG--RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
+EG + + K+ + ++E + G + L A E + LL+ AN R
Sbjct: 72 AEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNM 131
Query: 301 DITPLMAAANGGHVKIVKLLLAHKA-DVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS 359
+ PL A G + +++K+LL H+ DVN + GNTA+ AC + +++LL+ GA
Sbjct: 132 -MAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAK 190
Query: 360 IEDHNENGHTPLMEAGSAGHVEVARLLL----ENGAGINTH---SNEFKESALTLACYKG 412
N+ G P+ +A +G E ++L E+G H N K + L LA G
Sbjct: 191 PCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNG 250
Query: 413 HLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ----VNMPADSFE 468
LEM++ L+ GA + TA+ A G E+ +L++ S + VN E
Sbjct: 251 DLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHE 310
Query: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
+ L A+ H ELA LI GA + +++ EG +PL+ A +V LLL +GA ++
Sbjct: 311 TMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDI 370
Query: 529 QTEETQE-TALTLACCGGFLEVADFLIKAGADIEL-------GCSTPLMEAAQEGHLELV 580
+ + LT+ G + ++ EL GC TPL A ++G V
Sbjct: 371 KDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGC-TPLHYACRQGGPGSV 429
Query: 581 KYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG---GRTPLMKA 637
LL ++H+ + + L +A G + LLQ +D +EG G TPL A
Sbjct: 430 NNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLA 489
Query: 638 ARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRL-KD 696
A+ GH VQ L+ KGA + +N T L A GG+ ++++L T RL +D
Sbjct: 490 AKNGHDKVVQLLLKKGALF--LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDED 547
Query: 697 GSTMLIEAAKGGHTSVVCYLLDY 719
G+T L AA+ GH V LL +
Sbjct: 548 GNTALHFAAREGHAKAVALLLSH 570
Score = 101 bits (251), Expect = 1e-20
Identities = 98/367 (26%), Positives = 167/367 (45%), Gaps = 35/367 (9%)
Query: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132
ID++ + E N +TA+ +AC + E +Q LL++GA +K G P+ AA +G +
Sbjct: 156 IDVNLEGE-NGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECM 214
Query: 1133 EILLDNGADIEAQSE-------RTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYT 1185
EI+L G + + K TPL LA G E++++ L GA + T
Sbjct: 215 EIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCT 274
Query: 1186 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML--AAMNGHTAAVKLLLDMGSD 1243
+ AA+ G I+K+++++ + + G ML A++ H L+ +G+D
Sbjct: 275 AIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGAD 334
Query: 1244 INAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA----- 1298
IN +I++ + L LA +V+LLL + A V+ + G L Y
Sbjct: 335 IN-KIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLR 393
Query: 1299 -------EVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNK 1351
++ +++D+ D P L A +G L+G I ++K
Sbjct: 394 PEFMQMQQIKELVMDEDNDGCTP---------LHYACRQGGPGSVNNLLGFNVSIHSKSK 444
Query: 1352 KGNTPLWLAANGGHLDVVQLLVQAGAD---VDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
+PL AA+ G ++ Q L+Q +D ++ D +TPL A + GH KVV+ L+K+
Sbjct: 445 DKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK 504
Query: 1409 VNQFPSD 1415
F SD
Sbjct: 505 GALFLSD 511
Score = 96.3 bits (238), Expect = 4e-19
Identities = 86/322 (26%), Positives = 144/322 (44%), Gaps = 44/322 (13%)
Query: 1072 AIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 1131
++++ + + +T L A E V+ LL RGA+ R+ PL +A + V
Sbjct: 87 SLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEV 146
Query: 1132 VEILLDNGA-DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLA 1190
+++LL++ D+ + E +T + +AC+ E +++LL +GA N P+ A
Sbjct: 147 MKVLLEHRTIDVNLEGENG-NTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQA 205
Query: 1191 ASGGYVNIIKILLNAGAE--------INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS 1242
A G ++I+L G E IN K +PL LA NG +K+ LD G+
Sbjct: 206 AFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA--TPLHLAVQNGDLEMIKMCLDNGA 263
Query: 1243 DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1302
I+ +E R TA+ A QG TE+V L++ + +G ++ G +
Sbjct: 264 QIDP-VEKGRCTAIHFAATQGATEIVKLMIS--------SYSGSVDIVNTTDGCH----- 309
Query: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362
+T L A+ H++ + LI GA I+ + +G +PL LA
Sbjct: 310 ------------------ETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351
Query: 1363 GGHLDVVQLLVQAGADVDAADN 1384
++V LL+ GA VD DN
Sbjct: 352 SASWNIVNLLLSKGAQVDIKDN 373
Score = 93.6 bits (231), Expect = 2e-18
Identities = 94/313 (30%), Positives = 138/313 (44%), Gaps = 17/313 (5%)
Query: 1072 AIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 1131
++DI T+ H+T L A H EL L+ GA I D +G +PLILA + +
Sbjct: 298 SVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNI 357
Query: 1132 VEILLDNGADIEAQS-------ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY 1184
V +LL GA ++ + T P L R E +++ + + N
Sbjct: 358 VNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL--KNLRPEFMQMQQIKELVMDEDN-DGC 414
Query: 1185 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 1244
TPL A G + LL I+S++ K SPL AA G + LL SD
Sbjct: 415 TPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKK--SPLHFAASYGRINTCQRLLQDISDT 472
Query: 1245 NAQIETNRN--TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1302
E + + T L LA G +VV LLL +K + G T L A+ GGY + +
Sbjct: 473 RLLNEGDLHGMTPLHLAAKNGHDKVVQLLL-KKGALFLSDHNGWTALHHASMGGYTQTMK 531
Query: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362
V+LD + +TAL AA +GH K LL+ A I V NK+ + L LA +
Sbjct: 532 VILDTNLKC-TDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALH 589
Query: 1363 GGHLDVVQLLVQA 1375
+VV ++++
Sbjct: 590 NKRKEVVLTIIRS 602
Score = 86.7 bits (213), Expect = 3e-16
Identities = 77/301 (25%), Positives = 140/301 (46%), Gaps = 21/301 (6%)
Query: 1123 AATAGHVGVVE-ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 1181
AA G + ++E I D+ ++ + + +TPL A + E V+ LL+RGAN RN
Sbjct: 70 AAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNF 129
Query: 1182 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 1241
+ PL +A G ++K+LL I+ + G + +++A ++ A+++LL G
Sbjct: 130 NMMAPLHIAVQGMNNEVMKVLLE-HRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKG 188
Query: 1242 SDINAQIETNRNTALTL--ACFQGRTEVVSLLL--------DRKANVEHRAKTGLTPLME 1291
+ ++N+ + A F G E + ++L R+ ++ TPL
Sbjct: 189 A---KPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHL 245
Query: 1292 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR-GAHIDVRN 1350
A G E+ ++ LD GA ++ PV R TA+ AA +G + +L+I +D+ N
Sbjct: 246 AVQNGDLEMIKMCLDNGAQID--PVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVN 303
Query: 1351 KKG---NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
T L A+ H ++ L+ GAD++ D+ +PL+ A +V L+
Sbjct: 304 TTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLS 363
Query: 1408 E 1408
+
Sbjct: 364 K 364
Score = 73.6 bits (179), Expect = 2e-12
Identities = 100/437 (22%), Positives = 162/437 (37%), Gaps = 91/437 (20%)
Query: 213 DEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLC 272
+E L R G++ N ++ AC+ + A++ LL +G + + G +
Sbjct: 144 NEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIH 203
Query: 273 LACSAGYYELAQVLLA----------MHANVEDRGIKGDITPLMAAANGGHVKIVKLLLA 322
A +G E +++L +H N + G TPL A G ++++K+ L
Sbjct: 204 QAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNG---KATPLHLAVQNGDLEMIKMCLD 260
Query: 323 HKADVNAQSSTGNTALTYACAGGYVDVVKVLLES---GASIEDHNENGH-TPLMEAGSAG 378
+ A ++ TA+ +A G ++VK+++ S I + + H T L A
Sbjct: 261 NGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFD 320
Query: 379 HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKT------- 431
H E+A L+ GA IN +E + S L LA +V LL GA + K
Sbjct: 321 HHELADYLISVGADINKIDSEGR-SPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFL 379
Query: 432 ----------------------------DEMH---TALMEACMDGHVEVARLLLDSGAQV 460
DE + T L AC G LL +
Sbjct: 380 HLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSI 439
Query: 461 NMPADSFESPLTLAACGGHVELAALLIERGASLEEVND---EGYTPLMEAAREGHEEMVA 517
+ + +SPL AA G + L++ + +N+ G TPL AA+ GH+++V
Sbjct: 440 HSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQ 499
Query: 518 LLLGQGA--------------------------------NINAQTEETQETALTLACCGG 545
LLL +GA + +E TAL A G
Sbjct: 500 LLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREG 559
Query: 546 FLEVADFLIKAGADIEL 562
+ L+ ADI L
Sbjct: 560 HAKAVALLLSHNADIVL 576
Score = 71.6 bits (174), Expect = 9e-12
Identities = 81/345 (23%), Positives = 145/345 (42%), Gaps = 47/345 (13%)
Query: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
A GD+ ++ L G ++ + + + A + G E+ +++++ ++ D
Sbjct: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
Query: 301 D---ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
D T L A+ H ++ L++ AD+N S G + L A A ++V +LL G
Sbjct: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
Query: 358 ASIE--------------------------------------DHNENGHTPLMEAGSAGH 379
A ++ D + +G TPL A G
Sbjct: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGG 425
Query: 380 VEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD-EMH--T 436
LL I++ S + K+S L A G + + LL+ +D + ++H T
Sbjct: 426 PGSVNNLLGFNVSIHSKSKD-KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484
Query: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASL-EE 495
L A +GH +V +LLL GA + + + L A+ GG+ + ++++ +
Sbjct: 485 PLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTA-LHHASMGGYTQTMKVILDTNLKCTDR 543
Query: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
++++G T L AAREGH + VALLL A+I ++ L L
Sbjct: 544 LDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLAL 588
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 157 bits (398), Expect = 1e-37
Identities = 124/393 (31%), Positives = 194/393 (49%), Gaps = 53/393 (13%)
Query: 313 HVKIVKLLLAHKADVNAQSSTGNTA--LTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
+VK+ +LL+ A+VN ++ N A L G+ +VV +LLE GA ++ +ENG T
Sbjct: 904 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
Query: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA----GAD 426
L A +AGH+++ LL + G ++ H ++ + AL + +GH +++++LL G
Sbjct: 964 LCYAAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022
Query: 427 QE---HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGG 478
Q K+ + AL A GH V + LL + + + E+ LT AA G
Sbjct: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
Query: 479 HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538
+E+ LL+ GA++ N G PL AAR+GH ++V LLL +G ++N ++ +
Sbjct: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR---- 1138
Query: 539 TLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
TPLM AA EGHL V++LL+ GA + + G
Sbjct: 1139 ---------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1171
Query: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
+AL++AC GH V L++ GA ++ + GRTPL AA G TV +L+ KGA +
Sbjct: 1172 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1231
Query: 659 TTANNDHT---VLSLACAGGHLAVVELLLAHGA 688
DH+ L A + +VV LL GA
Sbjct: 1232 V----DHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
Score = 140 bits (352), Expect = 2e-32
Identities = 103/325 (31%), Positives = 161/325 (49%), Gaps = 17/325 (5%)
Query: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 467
Y ++++ R L+ GA+ ++T+ ++ A + GH EV LLL+ GA ++ +++
Sbjct: 901 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960
Query: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL------G 521
+ L AA GH++L LL ++G ++ ++ +G L+ +A GH +++ LL G
Sbjct: 961 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020
Query: 522 QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS--------TPLMEAAQ 573
+ + ALT A G V L+ + E+ + T L AA
Sbjct: 1021 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1080
Query: 574 EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 633
G LE+ + LL GA V T G L A GH + +LL+ G D+ + GRTP
Sbjct: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140
Query: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693
LM AA GH+ TV+FL+SKGA ++ + + LS AC GH AVV+ L+ GA
Sbjct: 1141 LMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQT 1199
Query: 694 LKDGSTMLIEAAKGGHTSVVCYLLD 718
K+G T L AA G V YL++
Sbjct: 1200 DKNGRTPLDLAAFYGDAETVLYLVE 1224
Score = 136 bits (342), Expect = 3e-31
Identities = 140/530 (26%), Positives = 228/530 (43%), Gaps = 40/530 (7%)
Query: 112 SSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTV-DPE 170
++ + + E+ +D ++ + + F++ + D + + L ADG + + +P
Sbjct: 770 NAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPR 829
Query: 171 TQARLEALLEAAGIGKLSTAD----GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAES 226
L A + + GKL+ G + + L+ + A E
Sbjct: 830 NGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEG 889
Query: 227 TANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTE--EGESLLCLACSAGYYELAQ 284
+ A + R+L +V R L++ G +VN TE +LC+ G+ E+
Sbjct: 890 LS-AALASLRNLYTP----NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVT 944
Query: 285 VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344
+LL A ++ G +T L AA GH+K+V LL V+ G AL ++
Sbjct: 945 LLLEFGACLDGTSENG-MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALR 1003
Query: 345 GYVDVVKVLL---------ESGASIEDHNENGHTPLMEAGSAGHVEVARLLL----ENGA 391
G+ D+++ LL + G + H L A S GH V + LL E+
Sbjct: 1004 GHGDILQYLLTCEWSPGPPQPGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEV 1061
Query: 392 GINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 451
+N + E+ALT A +G LE+ LL GA L A GH ++ R
Sbjct: 1062 EVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1121
Query: 452 LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREG 511
LLL+ G VN+ +PL +AAC GH+ L+ +GA+L ++ EG + L A +G
Sbjct: 1122 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1181
Query: 512 HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPL 568
H +V L+ +GA I+ QT++ T L LA G E +L++ GA IE PL
Sbjct: 1182 HRAVVQYLVEEGAAID-QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1240
Query: 569 MEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
A + +V LL GA + G+ A +A D+ +LLQ
Sbjct: 1241 DRAIGCRNTSVVVALLRKGAKL------GNAA--WAMATSKPDILIILLQ 1282
Score = 127 bits (318), Expect = 2e-28
Identities = 142/511 (27%), Positives = 214/511 (41%), Gaps = 73/511 (14%)
Query: 1028 AAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTAL 1087
A V+ R ++N P + + + + T +L +D T N TAL
Sbjct: 916 ANVNYRTEVLNNAPILCVQSHLGHEEVVT--------LLLEFGACLD---GTSENGMTAL 964
Query: 1088 TLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD------NGAD 1141
A A GH +LV L ++G ++H DKKG L+ +A GH +++ LL
Sbjct: 965 CYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQP 1024
Query: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR---NVSDY----TPLSLAASGG 1194
+ L+ A S G VV+ LL G KEH N +D T L+ AA G
Sbjct: 1025 GTLRKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
+ + ++LL GA + SRT + G+ PL AA
Sbjct: 1083 KLEVCELLLGHGAAV-SRTNRR-GVPPLFCAAR--------------------------- 1113
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
QG ++V LLL+R +V K G TPLM AA G+ LL KGA +++
Sbjct: 1114 -------QGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSS- 1165
Query: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
+ +AL+ A KGH + L+ GA ID +K G TPL LAA G + V LV+
Sbjct: 1166 -LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVE 1224
Query: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1434
GA ++ D+ + PL A + VV L+++ + + + M + D ++
Sbjct: 1225 KGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAM--ATSKPDILIILLQ 1282
Query: 1435 HLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESR-------RLALAAKREKRKEK 1487
L E V K + EA + L + E E+ R L L R +RK
Sbjct: 1283 KLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTN 1342
Query: 1488 RRKKKEEQRRKLEEIEAKNKENFELQAAQEK 1518
EE K E++ K+ E F +A ++
Sbjct: 1343 DFGMAEEFASKALELKPKSYEAFYARARAKR 1373
Score = 123 bits (308), Expect = 3e-27
Identities = 102/318 (32%), Positives = 152/318 (47%), Gaps = 14/318 (4%)
Query: 1102 LLERGASIEHRDKKGFTPLILAATA--GHVGVVEILLDNGADIEAQSERTKDTPLSLACS 1159
L+ GA++ +R + IL + GH VV +LL+ GA ++ SE T L A +
Sbjct: 911 LILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGM-TALCYAAA 969
Query: 1160 GGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1219
G ++V LL +G +H + L +A G+ +I++ LL L
Sbjct: 970 AGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRK 1029
Query: 1220 S-----PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN----TALTLACFQGRTEVVSL 1270
S L AA GH++ V+ LL M + ++ TALT A +G+ EV L
Sbjct: 1030 SHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCEL 1089
Query: 1271 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1330
LL A V + G+ PL AA G+ ++ R+LL++G DVN T L +AA +
Sbjct: 1090 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR--TPLMVAACE 1147
Query: 1331 GHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1390
GH E L+ +GA + +K+G + L A GH VVQ LV+ GA +D D TPL
Sbjct: 1148 GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPL 1207
Query: 1391 MAAFRKGHVKVVRYLVKE 1408
A G + V YLV++
Sbjct: 1208 DLAAFYGDAETVLYLVEK 1225
Score = 113 bits (282), Expect = 3e-24
Identities = 98/298 (32%), Positives = 147/298 (49%), Gaps = 26/298 (8%)
Query: 1128 HVGVVEILLDNGADIEAQSERTKDTPLSLACSG-GRQEVVELLLARGANKEHRNVSDYTP 1186
+V V +L+ GA++ ++E + P+ S G +EVV LLL GA + + + T
Sbjct: 904 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
Query: 1187 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG-SDIN 1245
L AA+ G++ ++ +L G ++ K G L+ +A+ GH ++ LL S
Sbjct: 964 LCYAAAAGHMKLVCLLTKKGVRVDHL--DKKGQCALVHSALRGHGDILQYLLTCEWSPGP 1021
Query: 1246 AQIETNRNT-----ALTLACFQGRTEVVSLLLDRKANVEHRAKT-------GLTPLMEAA 1293
Q T R + ALT A G + VV LL + EH + G T L AA
Sbjct: 1022 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK--EHEVEVNGTDTLWGETALTAAA 1079
Query: 1294 SGGYAEVGRVLLDKGADV---NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRN 1350
G EV +LL GA V N VP L AA +GH++ LL+ RG +++ +
Sbjct: 1080 GRGKLEVCELLLGHGAAVSRTNRRGVPP-----LFCAARQGHWQIVRLLLERGCDVNLSD 1134
Query: 1351 KKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
K+G TPL +AA GHL V+ L+ GA + + D ++ L A KGH VV+YLV+E
Sbjct: 1135 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1192
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 157 bits (398), Expect = 1e-37
Identities = 124/393 (31%), Positives = 194/393 (49%), Gaps = 53/393 (13%)
Query: 313 HVKIVKLLLAHKADVNAQSSTGNTA--LTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
+VK+ +LL+ A+VN ++ N A L G+ +VV +LLE GA ++ +ENG T
Sbjct: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
Query: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA----GAD 426
L A +AGH+++ LL + G ++ H ++ + AL + +GH +++++LL G
Sbjct: 972 LCYAAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030
Query: 427 QE---HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGG 478
Q K+ + AL A GH V + LL + + + E+ LT AA G
Sbjct: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
Query: 479 HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538
+E+ LL+ GA++ N G PL AAR+GH ++V LLL +G ++N ++ +
Sbjct: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR---- 1146
Query: 539 TLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
TPLM AA EGHL V++LL+ GA + + G
Sbjct: 1147 ---------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1179
Query: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
+AL++AC GH V L++ GA ++ + GRTPL AA G TV +L+ KGA +
Sbjct: 1180 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1239
Query: 659 TTANNDHT---VLSLACAGGHLAVVELLLAHGA 688
DH+ L A + +VV LL GA
Sbjct: 1240 V----DHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
Score = 147 bits (371), Expect = 1e-34
Identities = 178/710 (25%), Positives = 300/710 (42%), Gaps = 95/710 (13%)
Query: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 467
Y ++++ R L+ GA+ ++T+ ++ A + GH EV LLL+ GA ++ +++
Sbjct: 909 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 968
Query: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL------G 521
+ L AA GH++L LL ++G ++ ++ +G L+ +A GH +++ LL G
Sbjct: 969 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1028
Query: 522 QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS--------TPLMEAAQ 573
+ + ALT A G V L+ + E+ + T L AA
Sbjct: 1029 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1088
Query: 574 EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 633
G LE+ + LL GA V T G L A GH + +LL+ G D+ + GRTP
Sbjct: 1089 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1148
Query: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693
LM AA GH+ TV+FL+SKGA ++ + + LS AC GH AVV+ L+ GA
Sbjct: 1149 LMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQT 1207
Query: 694 LKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALP 753
K+G T L AA G V YL++ + D + + P L+RA
Sbjct: 1208 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHV---DHSGMRP----LDRAIGC------ 1254
Query: 754 MVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHLPANSQDVQGYITNQ-SPESIVEEAQ 812
N + + + K A ++ + + D+ + + E V +
Sbjct: 1255 ------------RNTSVVVALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKK 1302
Query: 813 GKLTELEQRIKEAIEK-------------------------NAQLQSLELAHADQLTKEK 847
GK+ E QR + A+ K + ++ + A++ +
Sbjct: 1303 GKMKEAAQRYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKA 1362
Query: 848 IE------ELNKTREEQIQKKQKILEELQKVERELQL-KTQQQLKKQYLEVKAQRIQLQQ 900
+E E R + ++ + L ++ ++L T Q++K+ V+ + QLQ+
Sbjct: 1363 LELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQR 1422
Query: 901 QQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKD-EPQQTAAQMGFAPIQPLAMP 959
QQQ Q G L P + + +E D D ++ E ++T+ Q P + P
Sbjct: 1423 SQQQKQQ--GPL-PAPLNDSENEEDTPTPGLSDHFHSEETEEEETSPQEESVSPTPRSQP 1479
Query: 960 QALPLAAGPLPPGSIANLTE-LQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQT 1018
+ +P I NL E LQ G+PV Q++ AG+G+ + Q ++ P++
Sbjct: 1480 ------SSSVPSSYIRNLQEGLQS--KGRPVSPQSR-AGIGKSLREPVAQPGLLLQPSKQ 1530
Query: 1019 LNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLP 1068
I+ S S S+ IS Q P PSP+ A P
Sbjct: 1531 A-----QIVKTSQHLGSGQSAVRNGSMKVQISS-QNPPPSPMPGRIAATP 1574
Score = 136 bits (342), Expect = 3e-31
Identities = 140/530 (26%), Positives = 228/530 (43%), Gaps = 40/530 (7%)
Query: 112 SSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTV-DPE 170
++ + + E+ +D ++ + + F++ + D + + L ADG + + +P
Sbjct: 778 NAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPR 837
Query: 171 TQARLEALLEAAGIGKLSTAD----GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAES 226
L A + + GKL+ G + + L+ + A E
Sbjct: 838 NGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEG 897
Query: 227 TANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTE--EGESLLCLACSAGYYELAQ 284
+ A + R+L +V R L++ G +VN TE +LC+ G+ E+
Sbjct: 898 LS-AALASLRNLYTP----NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVT 952
Query: 285 VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344
+LL A ++ G +T L AA GH+K+V LL V+ G AL ++
Sbjct: 953 LLLEFGACLDGTSENG-MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALR 1011
Query: 345 GYVDVVKVLL---------ESGASIEDHNENGHTPLMEAGSAGHVEVARLLL----ENGA 391
G+ D+++ LL + G + H L A S GH V + LL E+
Sbjct: 1012 GHGDILQYLLTCEWSPGPPQPGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEV 1069
Query: 392 GINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 451
+N + E+ALT A +G LE+ LL GA L A GH ++ R
Sbjct: 1070 EVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1129
Query: 452 LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREG 511
LLL+ G VN+ +PL +AAC GH+ L+ +GA+L ++ EG + L A +G
Sbjct: 1130 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1189
Query: 512 HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPL 568
H +V L+ +GA I+ QT++ T L LA G E +L++ GA IE PL
Sbjct: 1190 HRAVVQYLVEEGAAID-QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1248
Query: 569 MEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
A + +V LL GA + G+ A +A D+ +LLQ
Sbjct: 1249 DRAIGCRNTSVVVALLRKGAKL------GNAA--WAMATSKPDILIILLQ 1290
Score = 127 bits (318), Expect = 2e-28
Identities = 142/511 (27%), Positives = 214/511 (41%), Gaps = 73/511 (14%)
Query: 1028 AAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTAL 1087
A V+ R ++N P + + + + T +L +D T N TAL
Sbjct: 924 ANVNYRTEVLNNAPILCVQSHLGHEEVVT--------LLLEFGACLD---GTSENGMTAL 972
Query: 1088 TLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD------NGAD 1141
A A GH +LV L ++G ++H DKKG L+ +A GH +++ LL
Sbjct: 973 CYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQP 1032
Query: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR---NVSDY----TPLSLAASGG 1194
+ L+ A S G VV+ LL G KEH N +D T L+ AA G
Sbjct: 1033 GTLRKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
Query: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
+ + ++LL GA + SRT + G+ PL AA
Sbjct: 1091 KLEVCELLLGHGAAV-SRTNRR-GVPPLFCAAR--------------------------- 1121
Query: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
QG ++V LLL+R +V K G TPLM AA G+ LL KGA +++
Sbjct: 1122 -------QGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSS- 1173
Query: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
+ +AL+ A KGH + L+ GA ID +K G TPL LAA G + V LV+
Sbjct: 1174 -LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVE 1232
Query: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1434
GA ++ D+ + PL A + VV L+++ + + + M + D ++
Sbjct: 1233 KGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAM--ATSKPDILIILLQ 1290
Query: 1435 HLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESR-------RLALAAKREKRKEK 1487
L E V K + EA + L + E E+ R L L R +RK
Sbjct: 1291 KLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTN 1350
Query: 1488 RRKKKEEQRRKLEEIEAKNKENFELQAAQEK 1518
EE K E++ K+ E F +A ++
Sbjct: 1351 DFGMAEEFASKALELKPKSYEAFYARARAKR 1381
Score = 123 bits (308), Expect = 3e-27
Identities = 102/318 (32%), Positives = 152/318 (47%), Gaps = 14/318 (4%)
Query: 1102 LLERGASIEHRDKKGFTPLILAATA--GHVGVVEILLDNGADIEAQSERTKDTPLSLACS 1159
L+ GA++ +R + IL + GH VV +LL+ GA ++ SE T L A +
Sbjct: 919 LILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGM-TALCYAAA 977
Query: 1160 GGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1219
G ++V LL +G +H + L +A G+ +I++ LL L
Sbjct: 978 AGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRK 1037
Query: 1220 S-----PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN----TALTLACFQGRTEVVSL 1270
S L AA GH++ V+ LL M + ++ TALT A +G+ EV L
Sbjct: 1038 SHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCEL 1097
Query: 1271 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1330
LL A V + G+ PL AA G+ ++ R+LL++G DVN T L +AA +
Sbjct: 1098 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR--TPLMVAACE 1155
Query: 1331 GHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1390
GH E L+ +GA + +K+G + L A GH VVQ LV+ GA +D D TPL
Sbjct: 1156 GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPL 1215
Query: 1391 MAAFRKGHVKVVRYLVKE 1408
A G + V YLV++
Sbjct: 1216 DLAAFYGDAETVLYLVEK 1233
Score = 113 bits (282), Expect = 3e-24
Identities = 98/298 (32%), Positives = 147/298 (49%), Gaps = 26/298 (8%)
Query: 1128 HVGVVEILLDNGADIEAQSERTKDTPLSLACSG-GRQEVVELLLARGANKEHRNVSDYTP 1186
+V V +L+ GA++ ++E + P+ S G +EVV LLL GA + + + T
Sbjct: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
Query: 1187 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG-SDIN 1245
L AA+ G++ ++ +L G ++ K G L+ +A+ GH ++ LL S
Sbjct: 972 LCYAAAAGHMKLVCLLTKKGVRVDHL--DKKGQCALVHSALRGHGDILQYLLTCEWSPGP 1029
Query: 1246 AQIETNRNT-----ALTLACFQGRTEVVSLLLDRKANVEHRAKT-------GLTPLMEAA 1293
Q T R + ALT A G + VV LL + EH + G T L AA
Sbjct: 1030 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK--EHEVEVNGTDTLWGETALTAAA 1087
Query: 1294 SGGYAEVGRVLLDKGADV---NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRN 1350
G EV +LL GA V N VP L AA +GH++ LL+ RG +++ +
Sbjct: 1088 GRGKLEVCELLLGHGAAVSRTNRRGVPP-----LFCAARQGHWQIVRLLLERGCDVNLSD 1142
Query: 1351 KKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
K+G TPL +AA GHL V+ L+ GA + + D ++ L A KGH VV+YLV+E
Sbjct: 1143 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1200
Score = 32.0 bits (71), Expect = 8.2
Identities = 66/290 (22%), Positives = 104/290 (35%), Gaps = 47/290 (16%)
Query: 2275 SSQSTPESMLSGK--SSYLPNSDPLHQS-----DTSKAPGFRPPLQRPAPSPSGIVNMDS 2327
S TP S S SSY+ N QS G L+ P P G++ S
Sbjct: 1470 SVSPTPRSQPSSSVPSSYIRNLQEGLQSKGRPVSPQSRAGIGKSLREPVAQP-GLLLQPS 1528
Query: 2328 PYGSVTPSSTHLGNFASNISGGQM-------YGPGAPLGGAPAA--ANFNRQHFSPLSLL 2378
+ +S HLG+ S + G M P +P+ G AA A QH
Sbjct: 1529 KQAQIVKTSQHLGSGQSAVRNGSMKVQISSQNPPPSPMPGRIAATPAGSRTQHLEGTGTF 1588
Query: 2379 TPCSSASNDSSAQSVSSGVRA---------PSPAPSSVPLGSEKPSNVSQDRKVPVPIGT 2429
T + + S VR P P+ + S+V+ D P G
Sbjct: 1589 TTRAGCGHFGDRLGPSQNVRLQCGENGPAHPLPSKTKTTERLLSHSSVAVDAAPPNQGGL 1648
Query: 2430 ERSARIR---------QTGTSAPSVIGSNLSTSVGHSGIWS--FEGIGGN---QDKVDWC 2475
+ +R +G+ + S+ S+ ++S+ S +S F+ G + +DKV
Sbjct: 1649 ATCSDVRHPASLTSSGSSGSPSSSIKMSSSTSSLTSSSSFSDGFKVQGPDTRIKDKV--V 1706
Query: 2476 NPGMGNPMIHRPMSDP--GVFSQHQAMERDSTGIVTPSGTFHQHVPAGYM 2523
HRP + P G+ + ++ S PS ++H P G +
Sbjct: 1707 THVQSGTAEHRPRNTPFMGIMDKTARFQQQSN---PPSRSWHCPAPEGLL 1753
>gi|67906195 ankyrin repeat and sterile alpha motif domain containing
6 [Homo sapiens]
Length = 871
Score = 145 bits (367), Expect = 4e-34
Identities = 116/338 (34%), Positives = 169/338 (50%), Gaps = 26/338 (7%)
Query: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132
+ +D E+ + TAL A AGGHE LV+ LL RGAS+ R+ G++ L+ AA GHV V
Sbjct: 69 VPVDCSDEAGN-TALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVA 127
Query: 1133 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 1192
+LLD+GAD+ AQ+ R + L++A GG VV+LLL GA +H + S L L S
Sbjct: 128 HLLLDHGADVNAQN-RLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGS 185
Query: 1193 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1252
L I+ LM A +GH A V+LL++ G+D N T
Sbjct: 186 --------------------RDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVG 225
Query: 1253 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312
+ L LA GR V L+++ AN +H + T A + ++ LD V
Sbjct: 226 WSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVR 284
Query: 1313 APPVPSSRDTALTIAADKGHYKFC-ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
R + A G+++ E+ +H+++ N G TPL LAA G L +VQL
Sbjct: 285 PKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQL 344
Query: 1372 LVQAGADVDAADN-RKITPLMAAFRKGHVKVVRYLVKE 1408
LV+ ADVD D+ T LM A G+ ++V+YL+ +
Sbjct: 345 LVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQ 382
Score = 131 bits (329), Expect = 1e-29
Identities = 126/392 (32%), Positives = 178/392 (45%), Gaps = 39/392 (9%)
Query: 338 LTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH- 396
L AC G + + LLE GA+ + E G P A AG EVA +
Sbjct: 13 LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAG-AEVAGPGAAAAGAVGAPV 69
Query: 397 ----SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 452
S+E +AL A GH +VRFLL GA + +ALM+A GHV VA L
Sbjct: 70 PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129
Query: 453 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG------------ 500
LLD GA VN S LT+A+ GGH+ + LL+E GA ++ + G
Sbjct: 130 LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEP 189
Query: 501 --YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 558
T LM A + GHE +V LL+ GA+ N + L LA G L VA L++ GA
Sbjct: 190 LDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGA 249
Query: 559 D---IELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA-------LTYACENG 608
+ + + T A H +LV YL TT T + +A + G
Sbjct: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYLDPL------TTVRPKTDEEKRRPDIFHALKMG 303
Query: 609 HTD-VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTV 667
+ V ++ + + + + G TPLM AA G + VQ L+ + A+V++ + + T
Sbjct: 304 NFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTA 363
Query: 668 LSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
L A G+ +V+ LL GAD T R K+G T
Sbjct: 364 LMQATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
Score = 125 bits (313), Expect = 7e-28
Identities = 122/417 (29%), Positives = 183/417 (43%), Gaps = 25/417 (5%)
Query: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYEL---AQVLLAMHANVE 294
L AC +GD R+LL G + E E G A AG A A+ A V
Sbjct: 13 LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVP 70
Query: 295 -DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
D + T L AA GGH +V+ LL A VN+++ G +AL A G+V V +L
Sbjct: 71 VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
Query: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE----------- 402
L+ GA + N G + L A GH+ V +LLLE GA ++ H ++
Sbjct: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
Query: 403 --SALTLACYKGHLEMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQ 459
+AL A GH +VR L+E GAD H + + LM A + G + VA+ L++ GA
Sbjct: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
Query: 460 VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTP-LMEAAREGHEEMVAL 518
+ + ++ +A H +L L + ++E P + A + G+ ++V
Sbjct: 251 PDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKE 310
Query: 519 LLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS----TPLMEAAQE 574
+ + + T L LA G L + L++ AD++ S T LM+A
Sbjct: 311 IADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYH 370
Query: 575 GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 631
G+ E+VKYLL GA+V G TA D V L A ++ + GR
Sbjct: 371 GNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKGR 427
Score = 101 bits (251), Expect = 1e-20
Identities = 89/306 (29%), Positives = 137/306 (44%), Gaps = 62/306 (20%)
Query: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKG--------------FTP 1119
D++AQ + LT+A GGH +V+ LLE GA ++H G T
Sbjct: 136 DVNAQNRLGA-SVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITA 194
Query: 1120 LILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR 1179
L+ A GH VV +L++ GAD + +PL LA GR V + L+ +GAN +H
Sbjct: 195 LMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHL 254
Query: 1180 NVSDYTPLSLAASGGYVNIIKIL----------------------LNAG----------- 1206
+V + T +A + +++ L L G
Sbjct: 255 SVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADE 314
Query: 1207 --AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264
+ +N G G +PLMLAA+ G A V+LL++ +D++ Q + TAL A + G
Sbjct: 315 DPSHVNLVNGD--GATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGN 372
Query: 1265 TEVVSLLLDRKANVEHRAKTGLT--PLMEAASGGYAEVGRVLL--------DKGADVNAP 1314
E+V LL++ A+V RAK G T L+ + E+ R+L DKG + P
Sbjct: 373 KEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKGRPSHQP 432
Query: 1315 PVPSSR 1320
P+P S+
Sbjct: 433 PLPHSK 438
Score = 86.7 bits (213), Expect = 3e-16
Identities = 76/234 (32%), Positives = 104/234 (44%), Gaps = 19/234 (8%)
Query: 504 LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG 563
L+ A +G E LL GA A+ E A A GA + +
Sbjct: 13 LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD 72
Query: 564 CS-----TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
CS T L AA GH LV++LL GA+V++ G +AL A GH VA +LL
Sbjct: 73 CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
Query: 619 AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANN-------------DH 665
GAD+ ++ G + L A+R GH+ V+ L+ GA V+ + D
Sbjct: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDI 192
Query: 666 TVLSLACAGGHLAVVELLLAHGADPTHRLKD-GSTMLIEAAKGGHTSVVCYLLD 718
T L A GH AVV LL+ GADP H + G + L+ AA G V L++
Sbjct: 193 TALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVE 246
Score = 70.9 bits (172), Expect = 2e-11
Identities = 59/156 (37%), Positives = 75/156 (48%), Gaps = 7/156 (4%)
Query: 1256 LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP- 1314
L AC QG TE LL+ A A+ G P A G G GA V AP
Sbjct: 13 LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAGAEVAGPGAAAAGA-VGAPV 69
Query: 1315 PVPSSRD---TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
PV S + TAL AA GH L+ RGA ++ RN G + L AA GH+ V L
Sbjct: 70 PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129
Query: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
L+ GADV+A + + L A R GH+ VV+ L++
Sbjct: 130 LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLE 165
Score = 51.2 bits (121), Expect = 1e-05
Identities = 42/123 (34%), Positives = 55/123 (44%), Gaps = 6/123 (4%)
Query: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
L AC+ G T+ A LL+ GA +E G P A AG + GA
Sbjct: 13 LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVP 70
Query: 661 ANND----HTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716
+ +T L A AGGH +V LL GA R G + L++AA+ GH SV L
Sbjct: 71 VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
Query: 717 LDY 719
LD+
Sbjct: 131 LDH 133
Score = 40.4 bits (93), Expect = 0.023
Identities = 49/165 (29%), Positives = 68/165 (41%), Gaps = 34/165 (20%)
Query: 1927 FPVRPLSPARATNSPK----PHM--------VPRHSNQ--NSSGSQVNS----------- 1961
FP P SPA + NS PH V RH + N SG +++
Sbjct: 615 FPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGSIDNVLSQIAAQRKK 674
Query: 1962 -AGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNN 2020
AG L P+ SS PG+S + P+SP+ ++TS + +TT +
Sbjct: 675 AAGLLEQKPSHR-SSPVGPAPGSSPSELPASPAGGSAPVGKKLETSKRPPSGTSTT--SK 731
Query: 2021 NTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ---PGGVSRNSPLD 2062
+T+PT P P+ K H SS SS S Q GG S + D
Sbjct: 732 STSPT--LTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITD 774
Score = 32.3 bits (72), Expect = 6.3
Identities = 71/328 (21%), Positives = 115/328 (35%), Gaps = 44/328 (13%)
Query: 1964 SLTSSPTTTTSSSA--STVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTT---AS 2018
++ ++P TS SA P T NG S+ + +T + + A T + + A
Sbjct: 498 TMRAAPQDKTSRSALPDAAPVTKDNGPGSTRGEKEDTLLTTMLRNGAPLTRLPSDKLKAV 557
Query: 2019 NNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQE 2078
P ++ + + + + P A P SR P+ G V
Sbjct: 558 IPPFLPPSSFELWSSDRSRTRHNGKADPMKTALPQRASRGHPVGGGGTDTTPVR------ 611
Query: 2079 AGSPPVVETTNTRPPNSSSSSGS--SSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMT 2136
PV + R P SS++SG+ S HS+ VS+ L +S V
Sbjct: 612 ----PVKFPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGSIDNVLSQ 667
Query: 2137 VP-------------PLATSSAPVAVPSTAPVTYPMPQTPMGCPQPT-PKMETPAIRPPP 2182
+ P SS P ++P +P +P G P K+ET + PP
Sbjct: 668 IAAQRKKAAGLLEQKPSHRSSPVGPAPGSSPSE--LPASPAGGSAPVGKKLETS--KRPP 723
Query: 2183 HGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPST--LSTQSACQNSVHPANKP 2240
GT+ K S+ L+ + + H+ SSV S+ S S +S ++
Sbjct: 724 SGTSTTSK-------STSPTLTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDED 776
Query: 2241 IAPNFSAPLPFGPFSTLFENSPTSAHAF 2268
L + +FE AF
Sbjct: 777 ELTGILKKLSLEKYQPIFEEQEVDMEAF 804
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 142 bits (358), Expect = 4e-33
Identities = 116/319 (36%), Positives = 155/319 (48%), Gaps = 21/319 (6%)
Query: 1094 GHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 1153
G LV LL +GAS+E RD G TPL LA GH +V +LL GA + A +R T
Sbjct: 52 GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAV-DRAGRTA 110
Query: 1154 LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE--INS 1211
L A G V ELLL RGA+ R+ + TPL AA+ G+ + LL A +
Sbjct: 111 LHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAA 170
Query: 1212 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1271
G + AA G A ++LL G+ ++ AL +A GR + L
Sbjct: 171 EAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG--------ALLVAAAAGRGAALRFL 222
Query: 1272 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----TALTIA 1327
L R A V+ R G T L AA+ G ++ VLL GAD P RD +AL A
Sbjct: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGAD------PGIRDRHGRSALHRA 276
Query: 1328 ADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKI 1387
A +GH +LL+ +GA +D R+ G TPL A+ GH++V L+ GA VDA +
Sbjct: 277 AARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK 336
Query: 1388 TPLMAAFRKGHVKVVRYLV 1406
TPL A +GH V L+
Sbjct: 337 TPLHLAAERGHGPTVGLLL 355
Score = 130 bits (328), Expect = 1e-29
Identities = 117/319 (36%), Positives = 148/319 (46%), Gaps = 14/319 (4%)
Query: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464
L A ++G +V LL GA E + T L A + GH + RLLL GA V
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
Query: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL---G 521
+ + L AA GH +A LL++RGAS + G TPL AA GH + A LL G
Sbjct: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
Query: 522 QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVK 581
G + TA A GG L V + L GA G L+ AA G ++
Sbjct: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGA----GLDGALLVAAAAGRGAALR 220
Query: 582 YLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 641
+LLA GA V A G TAL A G + +VLL GAD GR+ L +AA G
Sbjct: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
Query: 642 HVCTVQFLISKGANVN-RTTANNDHTVLSLACAGGHLAVVELLLAHGA--DPTHRLKDGS 698
H+ VQ L+++GA V+ R T T L A GH+ V LL GA D T L+
Sbjct: 281 HLLAVQLLVTQGAEVDARDTLG--LTPLHHASREGHVEVAGCLLDRGAQVDATGWLR--K 336
Query: 699 TMLIEAAKGGHTSVVCYLL 717
T L AA+ GH V LL
Sbjct: 337 TPLHLAAERGHGPTVGLLL 355
Score = 127 bits (320), Expect = 1e-28
Identities = 108/295 (36%), Positives = 150/295 (50%), Gaps = 15/295 (5%)
Query: 1115 KGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGA 1174
+G+ L+ A G G+V LL GA +E + + TPL LA G +V LLL RGA
Sbjct: 40 QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGR-TPLHLAVLRGHAPLVRLLLQRGA 98
Query: 1175 NKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAV 1234
+ + T L AA G+ + ++LL GA +R+G+ G++PL AA GHT
Sbjct: 99 PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGT--GLTPLHWAAALGHTLLA 156
Query: 1235 KLLLDMGSD--INAQIETNRN-TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLME 1291
LL+ A+ E R TA A GR V+ LL A ++ L+
Sbjct: 157 ARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLV 209
Query: 1292 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNK 1351
AA+ G R LL +GA V+A + TAL +AA G + E+L+G GA +R++
Sbjct: 210 AAAAGRGAALRFLLARGARVDARDGAGA--TALGLAAALGRSQDIEVLLGHGADPGIRDR 267
Query: 1352 KGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
G + L AA GHL VQLLV GA+VDA D +TPL A R+GHV+V L+
Sbjct: 268 HGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322
Score = 120 bits (300), Expect = 2e-26
Identities = 104/292 (35%), Positives = 145/292 (49%), Gaps = 25/292 (8%)
Query: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD----NGA 1140
TAL A GH + + LL+RGAS R G TPL AA GH + LL+ A
Sbjct: 109 TALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPA 168
Query: 1141 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1200
EA+ R T A +GGR V+ELL A GA + L +AA+ G ++
Sbjct: 169 AAEAEDARGW-TAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALR 220
Query: 1201 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1260
LL GA +++R G+ G + L LAA G + +++LL G+D + R+ AL A
Sbjct: 221 FLLARGARVDARDGA--GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS-ALHRAA 277
Query: 1261 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320
+G V LL+ + A V+ R GLTPL A+ G+ EV LLD+GA V+A R
Sbjct: 278 ARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDA--TGWLR 335
Query: 1321 DTALTIAADKGHYKFCELLIGRGAHIDVRNK--------KGNTPLWLAANGG 1364
T L +AA++GH LL+ RGA +R + +G+ P L GG
Sbjct: 336 KTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPELGG 387
Score = 119 bits (299), Expect = 3e-26
Identities = 103/297 (34%), Positives = 151/297 (50%), Gaps = 17/297 (5%)
Query: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
T L LA GH LV+ LL+RGA + D+ G T L AA GH V E+LL GA A
Sbjct: 76 TPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAA 135
Query: 1145 QSERTKDTPLSLACSGGRQEV-VELLLARG---ANKEHRNVSDYTPLSLAASGGYVNIIK 1200
+S T TPL A + G + LL A G A E + +T AA+GG + +++
Sbjct: 136 RS-GTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLE 194
Query: 1201 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1260
+L GA ++ L++AA G AA++ LL G+ ++A+ + TAL LA
Sbjct: 195 LLAAGGAGLD---------GALLVAAAAGRGAALRFLLARGARVDAR-DGAGATALGLAA 244
Query: 1261 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320
GR++ + +LL A+ R + G + L AA+ G+ ++L+ +GA+V+A
Sbjct: 245 ALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGL- 303
Query: 1321 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1377
T L A+ +GH + L+ RGA +D TPL LAA GH V LL+ GA
Sbjct: 304 -TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
Score = 111 bits (278), Expect = 8e-24
Identities = 101/323 (31%), Positives = 144/323 (44%), Gaps = 30/323 (9%)
Query: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
L +A G V +LL +G SV E G + L LA G+ L ++LL A V
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
Query: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
G T L AA GH ++ +LLL A A+S TG T L +A A G+ + LLE+
Sbjct: 105 RAGR-TALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAP 163
Query: 358 ----ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN------------------- 394
A+ E + G T A + G + V LL GAG++
Sbjct: 164 GPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLL 223
Query: 395 ------THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVE 448
+ +AL LA G + + LL GAD + +AL A GH+
Sbjct: 224 ARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLL 283
Query: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
+LL+ GA+V+ +PL A+ GHVE+A L++RGA ++ TPL AA
Sbjct: 284 AVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAA 343
Query: 509 REGHEEMVALLLGQGANINAQTE 531
GH V LLL +GA+ +T+
Sbjct: 344 ERGHGPTVGLLLSRGASPTLRTQ 366
Score = 110 bits (275), Expect = 2e-23
Identities = 112/342 (32%), Positives = 154/342 (45%), Gaps = 17/342 (4%)
Query: 266 EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKA 325
+G L A G L LL A+VE+R G TPL A GH +V+LLL A
Sbjct: 40 QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGR-TPLHLAVLRGHAPLVRLLLQRGA 98
Query: 326 DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARL 385
V A G TAL A G+ V ++LL+ GAS + G TPL A + GH +A
Sbjct: 99 PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAAR 158
Query: 386 LLENGAGINTHSNEFKE----SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEA 441
LLE G + E ++ +A A G L ++ L GA + AL+ A
Sbjct: 159 LLE-APGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAG-------LDGALLVA 210
Query: 442 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGY 501
G R LL GA+V+ + + L LAA G + +L+ GA + G
Sbjct: 211 AAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGR 270
Query: 502 TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561
+ L AA GH V LL+ QGA ++A+ + T L A G +EVA L+ GA ++
Sbjct: 271 SALHRAAARGHLLAVQLLVTQGAEVDAR-DTLGLTPLHHASREGHVEVAGCLLDRGAQVD 329
Query: 562 LG---CSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
TPL AA+ GH V LL+ GA+ T + A
Sbjct: 330 ATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVA 371
Score = 84.0 bits (206), Expect = 2e-15
Identities = 61/159 (38%), Positives = 87/159 (54%), Gaps = 3/159 (1%)
Query: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 1143
D AL +A A G ++ LL RGA ++ RD G T L LAA G +E+LL +GAD
Sbjct: 204 DGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGAD-P 262
Query: 1144 AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203
+R + L A + G V+LL+ +GA + R+ TPL A+ G+V + LL
Sbjct: 263 GIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322
Query: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS 1242
+ GA++++ TG L +PL LAA GH V LLL G+
Sbjct: 323 DRGAQVDA-TG-WLRKTPLHLAAERGHGPTVGLLLSRGA 359
Score = 78.2 bits (191), Expect = 1e-13
Identities = 72/228 (31%), Positives = 105/228 (46%), Gaps = 16/228 (7%)
Query: 499 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 558
+G+ L++A G +V LL QGA++ + + T L LA G + L++ GA
Sbjct: 40 QGWGHLLQAVWRGPAGLVTQLLRQGASVE-ERDHAGRTPLHLAVLRGHAPLVRLLLQRGA 98
Query: 559 DI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADV 615
+ + T L EAA GH + + LL GA+ A + TG T L +A GHT +A
Sbjct: 99 PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAAR 158
Query: 616 LLQAG----ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671
LL+A A E E G T AA G + ++ L + GA ++ L +A
Sbjct: 159 LLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA--------LLVA 210
Query: 672 CAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
A G A + LLA GA R G+T L AA G + + LL +
Sbjct: 211 AAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGH 258
Score = 71.6 bits (174), Expect = 9e-12
Identities = 70/214 (32%), Positives = 97/214 (45%), Gaps = 13/214 (6%)
Query: 178 LLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRS 237
LLEA G G A A+ E R T++ A A L E A G + +
Sbjct: 159 LLEAPG-------PGPAAAEAEDARGWTAAHWAAAGGRLAVL-----ELLAAGGAGLDGA 206
Query: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
L A + G A+R LL G V+ G + L LA + G + +VLL A+ R
Sbjct: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
Query: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
G + L AA GH+ V+LL+ A+V+A+ + G T L +A G+V+V LL+ G
Sbjct: 267 RHGR-SALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRG 325
Query: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGA 391
A ++ TPL A GH LLL GA
Sbjct: 326 AQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
Score = 62.4 bits (150), Expect = 6e-09
Identities = 45/120 (37%), Positives = 53/120 (44%), Gaps = 1/120 (0%)
Query: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
L A G + LL+ GA +E GRTPL A GH V+ L+ +GA V
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
Query: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
T L A GH V ELLL GA R G T L AA GHT + LL+ P
Sbjct: 105 RAG-RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAP 163
Score = 54.7 bits (130), Expect = 1e-06
Identities = 42/129 (32%), Positives = 61/129 (47%), Gaps = 2/129 (1%)
Query: 1289 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDV 1348
L++A G A + LL +GA V + T L +A +GH LL+ RGA +
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERD--HAGRTPLHLAVLRGHAPLVRLLLQRGAPVGA 102
Query: 1349 RNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
++ G T L AA GH V +LL+Q GA A +TPL A GH + L++
Sbjct: 103 VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
Query: 1409 VNQFPSDSE 1417
P+ +E
Sbjct: 163 PGPGPAAAE 171
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.126 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 108,792,237
Number of Sequences: 37866
Number of extensions: 6012195
Number of successful extensions: 112081
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1141
Number of HSP's successfully gapped in prelim test: 2255
Number of HSP's that attempted gapping in prelim test: 42011
Number of HSP's gapped (non-prelim): 39904
length of query: 2603
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2484
effective length of database: 13,741,464
effective search space: 34133796576
effective search space used: 34133796576
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.