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Search of human proteins with 124517699
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|124517699 ankyrin repeat domain 13B [Homo sapiens]
(626 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|124517699 ankyrin repeat domain 13B [Homo sapiens] 1259 0.0
gi|46409340 ankyrin repeat domain 13 family, member D [Homo sapi... 660 0.0
gi|38683799 ankyrin repeat domain 13 [Homo sapiens] 588 e-168
gi|166795254 ankyrin repeat domain 13C [Homo sapiens] 236 5e-62
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 59 1e-08
gi|8051593 GA binding protein transcription factor, beta subunit... 54 3e-07
gi|8051595 GA binding protein transcription factor, beta subunit... 54 3e-07
gi|32483404 GA binding protein transcription factor, beta subuni... 54 3e-07
gi|8051597 GA binding protein transcription factor, beta subunit... 54 3e-07
gi|8051599 GA binding protein transcription factor, beta subunit... 54 3e-07
gi|58331117 ankyrin repeat domain 16 isoform c [Homo sapiens] 54 4e-07
gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens] 54 4e-07
gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens] 54 4e-07
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 53 1e-06
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 53 1e-06
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 52 2e-06
gi|18079216 CASK interacting protein 1 [Homo sapiens] 51 3e-06
gi|14150169 acyl-coenzyme A binding domain containing 6 [Homo sa... 51 3e-06
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 51 3e-06
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 51 3e-06
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 51 3e-06
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 51 4e-06
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 50 5e-06
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 50 5e-06
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 50 8e-06
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 50 8e-06
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 50 8e-06
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 50 8e-06
gi|56090539 dysferlin-interacting protein 1 [Homo sapiens] 50 8e-06
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 49 1e-05
>gi|124517699 ankyrin repeat domain 13B [Homo sapiens]
Length = 626
Score = 1259 bits (3259), Expect = 0.0
Identities = 626/626 (100%), Positives = 626/626 (100%)
Query: 1 MIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGH 60
MIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGH
Sbjct: 1 MIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGH 60
Query: 61 LECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLL 120
LECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLL
Sbjct: 61 LECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLL 120
Query: 121 EKLRKAQDFYVEMKWEFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGN 180
EKLRKAQDFYVEMKWEFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGN
Sbjct: 121 EKLRKAQDFYVEMKWEFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGN 180
Query: 181 RSFVFRGQDTSAVVMEIDHDRRVVYTETLALAGQDRELLLAAAQPTEEQVLSRLTAPVVT 240
RSFVFRGQDTSAVVMEIDHDRRVVYTETLALAGQDRELLLAAAQPTEEQVLSRLTAPVVT
Sbjct: 181 RSFVFRGQDTSAVVMEIDHDRRVVYTETLALAGQDRELLLAAAQPTEEQVLSRLTAPVVT 240
Query: 241 TQLDTKNISFERNKTGILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKV 300
TQLDTKNISFERNKTGILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKV
Sbjct: 241 TQLDTKNISFERNKTGILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKV 300
Query: 301 KGCKTPLQSFLGIAEQHGGPQNGTLITQTLSQANPTAITAEEYFNPNFELGNRDMGRPME 360
KGCKTPLQSFLGIAEQHGGPQNGTLITQTLSQANPTAITAEEYFNPNFELGNRDMGRPME
Sbjct: 301 KGCKTPLQSFLGIAEQHGGPQNGTLITQTLSQANPTAITAEEYFNPNFELGNRDMGRPME 360
Query: 361 LTTKTQKFKAKLWLCEEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIE 420
LTTKTQKFKAKLWLCEEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIE
Sbjct: 361 LTTKTQKFKAKLWLCEEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIE 420
Query: 421 IPIFHILNARITFGNLNGCDEPVPSVRGSPSSETPSPGSDSSSVSSSSSTTSCRGCEISP 480
IPIFHILNARITFGNLNGCDEPVPSVRGSPSSETPSPGSDSSSVSSSSSTTSCRGCEISP
Sbjct: 421 IPIFHILNARITFGNLNGCDEPVPSVRGSPSSETPSPGSDSSSVSSSSSTTSCRGCEISP 480
Query: 481 ALFEAPRGYSMMGGQREAATRDDDDDLLQFAIQQSLLEAGSEYDQVTIWEALTNSKPGTH 540
ALFEAPRGYSMMGGQREAATRDDDDDLLQFAIQQSLLEAGSEYDQVTIWEALTNSKPGTH
Sbjct: 481 ALFEAPRGYSMMGGQREAATRDDDDDLLQFAIQQSLLEAGSEYDQVTIWEALTNSKPGTH 540
Query: 541 PMSYEGRRQDRSAPPTPQRQPAPPASVPSPRPSSGPGSGGHVFRSYDEQLRLAMELSAQE 600
PMSYEGRRQDRSAPPTPQRQPAPPASVPSPRPSSGPGSGGHVFRSYDEQLRLAMELSAQE
Sbjct: 541 PMSYEGRRQDRSAPPTPQRQPAPPASVPSPRPSSGPGSGGHVFRSYDEQLRLAMELSAQE 600
Query: 601 QEERRRRARQEEEELERILRLSLTEQ 626
QEERRRRARQEEEELERILRLSLTEQ
Sbjct: 601 QEERRRRARQEEEELERILRLSLTEQ 626
>gi|46409340 ankyrin repeat domain 13 family, member D [Homo
sapiens]
Length = 518
Score = 660 bits (1704), Expect = 0.0
Identities = 337/537 (62%), Positives = 418/537 (77%), Gaps = 27/537 (5%)
Query: 96 LVQLVLRYRDYQRVVKRLAGIPVLLEKLRKAQDFYVEMKWEFTSWVPLVSKICPSDTYKV 155
+VQLVL+YRDYQR +RLAGIP LL KLR+A DFYVEMKWEFTSWVPLVSK+CPSD Y+V
Sbjct: 1 MVQLVLQYRDYQRATQRLAGIPELLNKLRQAPDFYVEMKWEFTSWVPLVSKMCPSDVYRV 60
Query: 156 WKSGQNLRVDTTLLGFDHMTWQRGNRSFVFRGQDTSAVVMEIDHDRRVVYTETLALAGQD 215
WK G++LRVDT+LLGF+H+TWQRG RSF+F+GQ+ A+VME+DHDR+VV+ ETL L Q+
Sbjct: 61 WKRGESLRVDTSLLGFEHVTWQRGRRSFIFKGQEAGALVMEVDHDRQVVHVETLGLTLQE 120
Query: 216 RELLLAAAQPTEEQVLSRLTAPVVTTQLDTKNISFERNKTGILGWRSEKTEMVNGYEAKV 275
E LLAA +P+EE V SRLT+P+V+T LDT+N++FERNK GI GWRSEK E V+GYEAKV
Sbjct: 121 PETLLAAMRPSEEHVASRLTSPIVSTHLDTRNVAFERNKCGIWGWRSEKMETVSGYEAKV 180
Query: 276 YGASNVELITRTRTEHLSEQHKGKVKGCKTPLQSFLGIAEQHGGPQNGTLITQTLSQANP 335
Y A+NVEL+TRTRTEHLS+Q K + K KTP QSFLG+A+QH G + Q S NP
Sbjct: 181 YSATNVELVTRTRTEHLSDQDKSRSKAGKTPFQSFLGMAQQHSS-HTGAPVQQAASPTNP 239
Query: 336 TAITAEEYFNPNFELGNRDMGRPMELTTKTQKFKAKLWLCEEHPLSLCEQVAPIIDLMAV 395
TAI+ EEYF+PNF L +R++GRP+E+++K Q+FKA LWL EEHPLSL +QV PIIDLMA+
Sbjct: 240 TAISPEEYFDPNFSLESRNIGRPIEMSSKVQRFKATLWLSEEHPLSLGDQVTPIIDLMAI 299
Query: 396 SNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDEPVPSVRGSPSSETP 455
SNA FAKLRDFITLRLPPGFPVKIEIP+FH+LNARITF NL GCDEP+ SV P
Sbjct: 300 SNAHFAKLRDFITLRLPPGFPVKIEIPLFHVLNARITFSNLCGCDEPLSSV------WVP 353
Query: 456 SPGSDSSSVSSSSSTTSCRGCEISPALFEAPRGYSMMGGQREAATRDDDDDLLQFAIQQS 515
+P SS+V++S + CE+ P +FE P GYS++G +R RD+DDDLLQFAIQQS
Sbjct: 354 AP---SSAVAASGNPFP---CEVDPTVFEVPNGYSVLGMERNEPLRDEDDDLLQFAIQQS 407
Query: 516 LLEAGSEYDQVTIWEALTNSKPGTHP----MSYEGRRQ-DRSAPPTPQ--RQPAPPASVP 568
LLEAG+E +QVT+WEALTN++PG P YE + Q +R+ + Q +P P S P
Sbjct: 408 LLEAGTEAEQVTVWEALTNTRPGARPPPQATVYEEQLQLERALQESLQLSTEPRGPGSPP 467
Query: 569 SPRPSSGPGSGGHVFRSYDEQLRLAMELSAQEQEERRRRARQEEEELERILRLSLTE 625
P+ GP S++EQLRLA+ELS++EQEER RR +QEEE+L+RIL+LSLTE
Sbjct: 468 RTPPAPGP-------PSFEEQLRLALELSSREQEERERRGQQEEEDLQRILQLSLTE 517
>gi|38683799 ankyrin repeat domain 13 [Homo sapiens]
Length = 590
Score = 588 bits (1516), Expect = e-168
Identities = 312/611 (51%), Positives = 409/611 (66%), Gaps = 31/611 (5%)
Query: 16 YPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVG 75
YPLH LVW N +R+LEKE++ GQ ++E +DPRGRT LHLA +LGHLE ARVLL H ADV
Sbjct: 11 YPLHLLVWKNDYRQLEKELQ-GQ-NVEAVDPRGRTLLHLAVSLGHLESARVLLRHKADVT 68
Query: 76 RENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLLEKLRKAQDFYVEMKW 135
+ENR GWTVL EAVST D E+V VL++RDY L G+P LL+K+ +A DFYV+MKW
Sbjct: 69 KENRQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLQKILEAPDFYVQMKW 128
Query: 136 EFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGNRSFVFRGQDTSAVVM 195
EFTSWVPLVS+ICP+D ++WKSG LRVD TLLGF++M+W RG RSF+F+G+D A +M
Sbjct: 129 EFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGEDNWAELM 188
Query: 196 EIDHDRRVVYTETLALAGQDRELLLAAAQPTEEQVLSRLTAPVVTTQLDTKNISFERNKT 255
E++HD +VV TE L+ + L L +P +V RLT+PV+ T LDTKNI+FER K+
Sbjct: 189 EVNHDDKVVTTERFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNIAFERTKS 248
Query: 256 GILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVKGCKTPLQSFLGIAE 315
G GWR++K E+VNGYEAKVY +NV +IT+ RTEHL+E+ K + K + PL+S LG E
Sbjct: 249 GFWGWRTDKAEVVNGYEAKVYTVNNVNVITKIRTEHLTEEEKKRYKADRNPLESLLGTVE 308
Query: 316 QHGGPQNGTLITQTLSQANPTAITAEEYFNPNFELGNRDMGRPMELTTKTQKFKAKLWLC 375
G Q G L T+ + NPTAIT +EYFN F+L +RD+GRP ELT +TQKFKA LW+C
Sbjct: 309 HQFGAQ-GDLTTECATANNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKFKAMLWMC 367
Query: 376 EEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGN 435
EE PLSL EQV PIIDLMA ++A FA+LRDFI L PPGFPVKIEIP+FH+LNARITFGN
Sbjct: 368 EEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLNARITFGN 427
Query: 436 LNGCDEPVPSVRGSPSSETPSPGSDSSSVSSSSSTTSCRGCEISPALFEAPRGYSMMGGQ 495
+NGC S + E+ S + + S+S T+ E+ ++FE P Y +
Sbjct: 428 VNGC---------STAEESVSQNVEGTQADSASHITN---FEVDQSVFEIPESYYVQDNG 475
Query: 496 REAATRDDDDDLLQFAIQQSLLEAGSEYDQVTIWEALTNSKPGTHPMSYEGRRQDRSAPP 555
R +D+D +++QFAIQQSLLE+ + S+ T+ YE Q+
Sbjct: 476 RNVHLQDEDYEIMQFAIQQSLLESSRSQELSGPASNGGISQTNTYDAQYERAIQESLLTS 535
Query: 556 TPQRQPAPPASVPSPRPSSGPGSGGHVFRSYDEQLRLAMELSAQEQEERRRRARQEEEEL 615
T P+ + +D L+LAMELSA+E EE R ++EE EL
Sbjct: 536 TEGLCPSALSET----------------SRFDNDLQLAMELSAKELEEWELRLQEEEAEL 579
Query: 616 ERILRLSLTEQ 626
+++L+LSLT++
Sbjct: 580 QQVLQLSLTDK 590
>gi|166795254 ankyrin repeat domain 13C [Homo sapiens]
Length = 541
Score = 236 bits (602), Expect = 5e-62
Identities = 153/419 (36%), Positives = 232/419 (55%), Gaps = 21/419 (5%)
Query: 16 YPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVG 75
YP+H V+ R L +R +I Q D G TPLHLA LG+ ECA +LLAH A V
Sbjct: 114 YPVHECVFKGDVRRLSSLIRTH--NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVK 171
Query: 76 RENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLLEKLRKAQDFYVEMKW 135
+N GW+ L EA+S D +++ +LR Q P LL+ L++ DFY+E+ W
Sbjct: 172 VKNAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELGDFYLELHW 231
Query: 136 EFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGNRSFVFRGQDTSAVVM 195
+F SWVPL+S+I PSD K++K G N+R+DTTL+ F M QRG+ SF+F G +
Sbjct: 232 DFQSWVPLLSRILPSDACKIYKQGINIRLDTTLIDFTDMKCQRGDLSFIFNGDAAPSESF 291
Query: 196 EIDHDRRVVYTETLALAGQDRELLLAAAQPTEEQVLSRLTAPVVTTQLDTKNISFERNKT 255
+ + + VY + ++ E+ TEE+V +++ + + L TK+ISF R +T
Sbjct: 292 VVLDNEQKVYQR---IHHEESEM------ETEEEVDILMSSDIYSATLSTKSISFTRAQT 342
Query: 256 GILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVKGCKTPLQSFLGIAE 315
G L +R +KTE V + A Y + + L +R R EHLSE+ + K L I E
Sbjct: 343 GWL-FREDKTERVGNFLADFYLVNGLVLESRKRREHLSEEDILRNKAIMESLSKGGNIME 401
Query: 316 QHGGPQNGTLITQTLSQANPTAITAEEYFNPNFELGNR-DMGRPMELTTKTQKFKAKLWL 374
Q+ P + Q+L+ IT EEY + E G +GR + + FKA + +
Sbjct: 402 QNFEP----IRRQSLTPPPQNTITWEEYISA--ENGKAPHLGRELVCKESKKTFKATIAM 455
Query: 375 CEEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITF 433
+E PL + E + +++++A F KLR+F+ ++LPPGFPVK++IP+F + A +TF
Sbjct: 456 SQEFPLGI-ELLLNVLEVVAPFKH-FNKLREFVQMKLPPGFPVKLDIPVFPTITATVTF 512
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 59.3 bits (142), Expect = 1e-08
Identities = 32/89 (35%), Positives = 52/89 (58%), Gaps = 1/89 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G+ LH+ V H+ H E + + D + R PLH A LGHLE ++L+A GAD
Sbjct: 140 GRSALHHAV-HSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD 198
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVLR 102
+G ++R G+ +L A ++ +E+V+ +LR
Sbjct: 199 LGCKDRKGYGLLHTAAASGQIEVVKYLLR 227
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/86 (37%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD-VG 75
PLH L +N H E K + V+++ D +GRT L LAT G EC VL AHGA +
Sbjct: 588 PLH-LAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALI 646
Query: 76 RENRSGWTVLQEAVSTRDLELVQLVL 101
+E + WT L A ++ + + L++
Sbjct: 647 KERKRKWTPLHAAAASGHTDSLHLLI 672
Score = 45.8 bits (107), Expect = 1e-04
Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 17/101 (16%)
Query: 7 SARKGPEGKYPLHYLVWHNRHRELEKEVRAGQV-----------------DIEQLDPRGR 49
+AR+G +PLH V K + +GQ+ DI D GR
Sbjct: 365 TARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGR 424
Query: 50 TPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVS 90
T LH A + G++EC +LL+ GAD+ R ++ G T L A +
Sbjct: 425 TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAA 465
Score = 44.3 bits (103), Expect = 3e-04
Identities = 28/86 (32%), Positives = 41/86 (47%), Gaps = 1/86 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRA-GQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVG 75
PLH V +N+ E + A G + D +GRTPLH A ++ R+LL H A+V
Sbjct: 826 PLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN 885
Query: 76 RENRSGWTVLQEAVSTRDLELVQLVL 101
+ +G T L A V+ +L
Sbjct: 886 ATDHTGRTALMTAAENGQTAAVEFLL 911
Score = 43.5 bits (101), Expect = 6e-04
Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 1/64 (1%)
Query: 13 EGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGA 72
EGK PLH H R + ++ G +I+ D G TPLH+A GH L+ +GA
Sbjct: 305 EGKSPLHMAAIHGRFTRSQILIQNGS-EIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363
Query: 73 DVGR 76
D R
Sbjct: 364 DTAR 367
Score = 38.9 bits (89), Expect = 0.014
Identities = 23/79 (29%), Positives = 44/79 (55%)
Query: 25 NRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTV 84
+R E + + + + +I LD RTPLH A +G + ++LL GA+V ++ T
Sbjct: 18 SRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTP 77
Query: 85 LQEAVSTRDLELVQLVLRY 103
L A ++R+ +++ L+L +
Sbjct: 78 LHRAAASRNEKVLGLLLAH 96
Score = 37.7 bits (86), Expect = 0.032
Identities = 18/42 (42%), Positives = 25/42 (59%)
Query: 37 GQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGREN 78
G+ D+ LD T LHLA + GH +CA ++LA D+G N
Sbjct: 914 GKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLIN 955
Score = 37.0 bits (84), Expect = 0.055
Identities = 26/85 (30%), Positives = 41/85 (48%), Gaps = 1/85 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH +R+ ++ + A D+ D +TPLH+A +CA L + +
Sbjct: 77 PLHRAA-ASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNV 135
Query: 77 ENRSGWTVLQEAVSTRDLELVQLVL 101
+RSG + L AV + LE V L+L
Sbjct: 136 ADRSGRSALHHAVHSGHLETVNLLL 160
Score = 37.0 bits (84), Expect = 0.055
Identities = 19/52 (36%), Positives = 27/52 (51%)
Query: 40 DIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVST 91
D+ + D GRTPLH A G +CA L+ GA V + G + L A ++
Sbjct: 448 DLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAAS 499
Score = 36.2 bits (82), Expect = 0.093
Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 2/65 (3%)
Query: 27 HRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQ 86
H ++ RA D+ +D G+TPL LA GH++C +LL G+ + G T L
Sbjct: 669 HLLIDSGERADITDV--MDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALH 726
Query: 87 EAVST 91
T
Sbjct: 727 RGAVT 731
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Query: 15 KYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADV 74
+ PLH+ + H E+ K + A D+ D +G LH A G +E + LL GA++
Sbjct: 174 RQPLHWAAFLG-HLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEI 232
Query: 75 GRENRSGWTVLQEA 88
N G T L A
Sbjct: 233 DEPNAFGNTALHIA 246
Score = 32.7 bits (73), Expect = 1.0
Identities = 22/63 (34%), Positives = 35/63 (55%), Gaps = 1/63 (1%)
Query: 40 DIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQ-EAVSTRDLELVQ 98
+I++ + G T LH+A LG A L+ GA+V + N G+T L AVST ++
Sbjct: 231 EIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLE 290
Query: 99 LVL 101
L++
Sbjct: 291 LLV 293
Score = 31.6 bits (70), Expect = 2.3
Identities = 21/67 (31%), Positives = 34/67 (50%), Gaps = 6/67 (8%)
Query: 45 DPRGRTPLHLATTLGHLECARVLL-----AHGADVGRENRSGWTVLQEAVSTRDLELVQL 99
D +GRTP+HLA+ GH R LL D G + SG++ + A T + ++L
Sbjct: 751 DFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAG-VDYSGYSPMHWASYTGHEDCLEL 809
Query: 100 VLRYRDY 106
+L + +
Sbjct: 810 LLEHSPF 816
Score = 31.2 bits (69), Expect = 3.0
Identities = 23/77 (29%), Positives = 38/77 (49%), Gaps = 2/77 (2%)
Query: 13 EGKYPLHYL-VWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHG 71
+G PLH V N LE V G D+ G++PLH+A G +++L+ +G
Sbjct: 271 KGFTPLHVAAVSTNGALCLELLVNNG-ADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNG 329
Query: 72 ADVGRENRSGWTVLQEA 88
+++ ++ G T L A
Sbjct: 330 SEIDCADKFGNTPLHVA 346
Score = 31.2 bits (69), Expect = 3.0
Identities = 29/121 (23%), Positives = 48/121 (39%), Gaps = 29/121 (23%)
Query: 9 RKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLA------------T 56
R+ G+ PLHY + ++ V AG + + D +G +PLH A T
Sbjct: 451 RRDKFGRTPLHYAAANGSYQCAVTLVTAG-AGVNEADCKGCSPLHYAAASDTYRRAEPHT 509
Query: 57 TLGH----------------LECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLV 100
H C LL +GAD +R G+T + A + + + ++L+
Sbjct: 510 PSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELL 569
Query: 101 L 101
L
Sbjct: 570 L 570
Score = 30.4 bits (67), Expect = 5.1
Identities = 23/80 (28%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 13 EGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGA 72
E + PLH + L+ + +G ++ D TPLH A + + +LLAH A
Sbjct: 40 ERRTPLHAAAYVGDVPILQLLLMSG-ANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSA 98
Query: 73 DVGRENRSGWTVLQEAVSTR 92
DV ++ T L A + R
Sbjct: 99 DVNARDKLWQTPLHVAAANR 118
>gi|8051593 GA binding protein transcription factor, beta subunit 1
isoform beta 1 [Homo sapiens]
Length = 395
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/90 (35%), Positives = 45/90 (50%), Gaps = 1/90 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH + + E +RAG V + RTPLH+A + GH VLL HGAD
Sbjct: 38 GTSPLHLAAQYGHYSTTEVLLRAG-VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGAD 96
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
V ++ T L A E+V+L+++Y
Sbjct: 97 VNAKDMLKMTALHWATEHNHQEVVELLIKY 126
Score = 32.7 bits (73), Expect = 1.0
Identities = 21/84 (25%), Positives = 38/84 (45%), Gaps = 1/84 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH +E ++ G D+ D T LH AT H E +L+ +GADV
Sbjct: 74 PLHMAASEGHASIVEVLLKHG-ADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
Query: 77 ENRSGWTVLQEAVSTRDLELVQLV 100
+++ T ++ + +L +++
Sbjct: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
>gi|8051595 GA binding protein transcription factor, beta subunit 1
isoform beta 2 [Homo sapiens]
Length = 383
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/90 (35%), Positives = 45/90 (50%), Gaps = 1/90 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH + + E +RAG V + RTPLH+A + GH VLL HGAD
Sbjct: 38 GTSPLHLAAQYGHYSTTEVLLRAG-VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGAD 96
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
V ++ T L A E+V+L+++Y
Sbjct: 97 VNAKDMLKMTALHWATEHNHQEVVELLIKY 126
Score = 32.7 bits (73), Expect = 1.0
Identities = 21/84 (25%), Positives = 38/84 (45%), Gaps = 1/84 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH +E ++ G D+ D T LH AT H E +L+ +GADV
Sbjct: 74 PLHMAASEGHASIVEVLLKHG-ADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
Query: 77 ENRSGWTVLQEAVSTRDLELVQLV 100
+++ T ++ + +L +++
Sbjct: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
>gi|32483404 GA binding protein transcription factor, beta subunit 1
isoform gamma 2 [Homo sapiens]
Length = 348
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/90 (35%), Positives = 45/90 (50%), Gaps = 1/90 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH + + E +RAG V + RTPLH+A + GH VLL HGAD
Sbjct: 38 GTSPLHLAAQYGHYSTTEVLLRAG-VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGAD 96
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
V ++ T L A E+V+L+++Y
Sbjct: 97 VNAKDMLKMTALHWATEHNHQEVVELLIKY 126
Score = 32.7 bits (73), Expect = 1.0
Identities = 21/84 (25%), Positives = 38/84 (45%), Gaps = 1/84 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH +E ++ G D+ D T LH AT H E +L+ +GADV
Sbjct: 74 PLHMAASEGHASIVEVLLKHG-ADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
Query: 77 ENRSGWTVLQEAVSTRDLELVQLV 100
+++ T ++ + +L +++
Sbjct: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
>gi|8051597 GA binding protein transcription factor, beta subunit 1
isoform gamma 1 [Homo sapiens]
Length = 360
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/90 (35%), Positives = 45/90 (50%), Gaps = 1/90 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH + + E +RAG V + RTPLH+A + GH VLL HGAD
Sbjct: 38 GTSPLHLAAQYGHYSTTEVLLRAG-VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGAD 96
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
V ++ T L A E+V+L+++Y
Sbjct: 97 VNAKDMLKMTALHWATEHNHQEVVELLIKY 126
Score = 32.7 bits (73), Expect = 1.0
Identities = 21/84 (25%), Positives = 38/84 (45%), Gaps = 1/84 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH +E ++ G D+ D T LH AT H E +L+ +GADV
Sbjct: 74 PLHMAASEGHASIVEVLLKHG-ADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
Query: 77 ENRSGWTVLQEAVSTRDLELVQLV 100
+++ T ++ + +L +++
Sbjct: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
>gi|8051599 GA binding protein transcription factor, beta subunit 1
isoform gamma 2 [Homo sapiens]
Length = 348
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/90 (35%), Positives = 45/90 (50%), Gaps = 1/90 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH + + E +RAG V + RTPLH+A + GH VLL HGAD
Sbjct: 38 GTSPLHLAAQYGHYSTTEVLLRAG-VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGAD 96
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
V ++ T L A E+V+L+++Y
Sbjct: 97 VNAKDMLKMTALHWATEHNHQEVVELLIKY 126
Score = 32.7 bits (73), Expect = 1.0
Identities = 21/84 (25%), Positives = 38/84 (45%), Gaps = 1/84 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH +E ++ G D+ D T LH AT H E +L+ +GADV
Sbjct: 74 PLHMAASEGHASIVEVLLKHG-ADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
Query: 77 ENRSGWTVLQEAVSTRDLELVQLV 100
+++ T ++ + +L +++
Sbjct: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
>gi|58331117 ankyrin repeat domain 16 isoform c [Homo sapiens]
Length = 304
Score = 53.9 bits (128), Expect = 4e-07
Identities = 30/93 (32%), Positives = 46/93 (49%)
Query: 11 GPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAH 70
GP G LH H L A +DIE + + PLH A ++GH +C R LL
Sbjct: 34 GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR 93
Query: 71 GADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
GA V ++ WT L A + ++L ++Q ++ +
Sbjct: 94 GAAVDCLKKADWTPLMMACTRKNLGVIQELVEH 126
Score = 34.3 bits (77), Expect = 0.35
Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
Query: 49 RTPLHLATTLGHLECARVLLAH-GADVGRENRSGWTVLQEAVSTRDLELVQLVL 101
RTPLH A GHLE +VLL + + G T L +A+ +++ +L+L
Sbjct: 172 RTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL 225
>gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens]
Length = 361
Score = 53.9 bits (128), Expect = 4e-07
Identities = 30/93 (32%), Positives = 46/93 (49%)
Query: 11 GPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAH 70
GP G LH H L A +DIE + + PLH A ++GH +C R LL
Sbjct: 34 GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR 93
Query: 71 GADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
GA V ++ WT L A + ++L ++Q ++ +
Sbjct: 94 GAAVDCLKKADWTPLMMACTRKNLGVIQELVEH 126
Score = 34.3 bits (77), Expect = 0.35
Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
Query: 49 RTPLHLATTLGHLECARVLLAH-GADVGRENRSGWTVLQEAVSTRDLELVQLVL 101
RTPLH A GHLE +VLL + + G T L +A+ +++ +L+L
Sbjct: 172 RTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL 225
Score = 33.1 bits (74), Expect = 0.79
Identities = 19/54 (35%), Positives = 25/54 (46%), Gaps = 1/54 (1%)
Query: 18 LHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHG 71
LHY ++ + G DI D + R+ LHLA HL CA+ LL G
Sbjct: 278 LHYAAKEGHTSTIQTLLSLG-ADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
>gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens]
Length = 361
Score = 53.9 bits (128), Expect = 4e-07
Identities = 30/93 (32%), Positives = 46/93 (49%)
Query: 11 GPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAH 70
GP G LH H L A +DIE + + PLH A ++GH +C R LL
Sbjct: 34 GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR 93
Query: 71 GADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
GA V ++ WT L A + ++L ++Q ++ +
Sbjct: 94 GAAVDCLKKADWTPLMMACTRKNLGVIQELVEH 126
Score = 34.3 bits (77), Expect = 0.35
Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
Query: 49 RTPLHLATTLGHLECARVLLAH-GADVGRENRSGWTVLQEAVSTRDLELVQLVL 101
RTPLH A GHLE +VLL + + G T L +A+ +++ +L+L
Sbjct: 172 RTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL 225
Score = 33.1 bits (74), Expect = 0.79
Identities = 19/54 (35%), Positives = 25/54 (46%), Gaps = 1/54 (1%)
Query: 18 LHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHG 71
LHY ++ + G DI D + R+ LHLA HL CA+ LL G
Sbjct: 278 LHYAAKEGHTSTIQTLLSLG-ADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 52.8 bits (125), Expect = 1e-06
Identities = 31/81 (38%), Positives = 43/81 (53%), Gaps = 1/81 (1%)
Query: 22 VWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSG 81
VW + + +R G +E+ D GRTPLHLA GH R+LL GA VG +R+G
Sbjct: 49 VWRGPAGLVTQLLRQG-ASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
Query: 82 WTVLQEAVSTRDLELVQLVLR 102
T L EA + +L+L+
Sbjct: 108 RTALHEAAWHGHSRVAELLLQ 128
Score = 41.6 bits (96), Expect = 0.002
Identities = 24/61 (39%), Positives = 32/61 (52%)
Query: 41 IEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLV 100
++ D G T L LA LG + VLL HGAD G +R G + L A + L VQL+
Sbjct: 229 VDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
Query: 101 L 101
+
Sbjct: 289 V 289
Score = 41.2 bits (95), Expect = 0.003
Identities = 31/91 (34%), Positives = 41/91 (45%), Gaps = 5/91 (5%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGH-LECARVLLAHG- 71
G+ LH WH R E ++ G G TPLH A LGH L AR+L A G
Sbjct: 107 GRTALHEAAWHGHSRVAELLLQRG-ASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGP 165
Query: 72 --ADVGRENRSGWTVLQEAVSTRDLELVQLV 100
A E+ GWT A + L +++L+
Sbjct: 166 GPAAAEAEDARGWTAAHWAAAGGRLAVLELL 196
Score = 37.4 bits (85), Expect = 0.042
Identities = 25/77 (32%), Positives = 34/77 (44%), Gaps = 1/77 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G+ PLH V H L + + + +D GRT LH A GH A +LL GA
Sbjct: 74 GRTPLHLAVLRG-HAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGAS 132
Query: 74 VGRENRSGWTVLQEAVS 90
+ +G T L A +
Sbjct: 133 AAARSGTGLTPLHWAAA 149
Score = 34.7 bits (78), Expect = 0.27
Identities = 19/57 (33%), Positives = 28/57 (49%)
Query: 45 DPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVL 101
D GR+ LH A GHL ++L+ GA+V + G T L A +E+ +L
Sbjct: 266 DRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322
Score = 34.3 bits (77), Expect = 0.35
Identities = 18/43 (41%), Positives = 25/43 (58%), Gaps = 3/43 (6%)
Query: 40 DIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGW 82
+++ D G TPLH A+ GH+E A LL GA V + +GW
Sbjct: 294 EVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQV---DATGW 333
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 52.8 bits (125), Expect = 1e-06
Identities = 32/93 (34%), Positives = 50/93 (53%), Gaps = 3/93 (3%)
Query: 13 EGKY--PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAH 70
EG++ PLH+ +NR +E + G D+ D G PLH A + GH E A +L+ H
Sbjct: 681 EGRHSTPLHFAAGYNRVSVVEYLLHHG-ADVHAKDKGGLVPLHNACSYGHYEVAELLVRH 739
Query: 71 GADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
GA V + +T L EA + E+ +L+L++
Sbjct: 740 GASVNVADLWKFTPLHEAAAKGKYEICKLLLKH 772
Score = 50.8 bits (120), Expect = 4e-06
Identities = 31/87 (35%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH +NR R ++ ++ G D+ D G PLH A + GH E +LL HGA V
Sbjct: 372 PLHLAAGYNRVRIVQLLLQHG-ADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 430
Query: 77 ENRSGWTVLQEAVSTRDLELVQLVLRY 103
+ +T L EA S +E+ L+L +
Sbjct: 431 MDLWQFTPLHEAASKNRVEVCSLLLSH 457
Score = 48.5 bits (114), Expect = 2e-05
Identities = 25/72 (34%), Positives = 37/72 (51%)
Query: 47 RGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDY 106
R TPLHLA +LE A LL HGADV +++ G L A S +++ L+++Y
Sbjct: 836 RNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTC 895
Query: 107 QRVVKRLAGIPV 118
+ A P+
Sbjct: 896 VNATDKWAFTPL 907
Score = 43.9 bits (102), Expect = 4e-04
Identities = 23/65 (35%), Positives = 35/65 (53%)
Query: 39 VDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQ 98
V+ D R TPLHLA + ++LL HGADV +++ G L A S E+ +
Sbjct: 360 VNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTE 419
Query: 99 LVLRY 103
L+L++
Sbjct: 420 LLLKH 424
Score = 43.1 bits (100), Expect = 8e-04
Identities = 25/87 (28%), Positives = 42/87 (48%), Gaps = 1/87 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH+ R +E ++ G ++ D G PLH A + GH E +LL GAD
Sbjct: 219 PLHFAAGFGRKDVVEHLLQMG-ANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNA 277
Query: 77 ENRSGWTVLQEAVSTRDLELVQLVLRY 103
+ +T L EA +++ ++L++
Sbjct: 278 RDNWNYTPLHEAAIKGKIDVCIVLLQH 304
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/91 (34%), Positives = 42/91 (46%), Gaps = 2/91 (2%)
Query: 10 KGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLA 69
K G PLH + + E VR G + D TPLH A G E ++LL
Sbjct: 713 KDKGGLVPLHNACSYGHYEVAELLVRHG-ASVNVADLWKFTPLHEAAAKGKYEICKLLLK 771
Query: 70 HGADVGRENRSGWTVLQEAVSTRDLELVQLV 100
HGAD ++NR G T L + V D ++ L+
Sbjct: 772 HGADPTKKNRDGNTPL-DLVKEGDTDIQDLL 801
Score = 42.4 bits (98), Expect = 0.001
Identities = 25/76 (32%), Positives = 39/76 (51%), Gaps = 1/76 (1%)
Query: 29 ELEKEVRAGQ-VDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQE 87
E K++ + Q V+ L+ R TPLH A + LL HGADV +++ G L
Sbjct: 664 ETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHN 723
Query: 88 AVSTRDLELVQLVLRY 103
A S E+ +L++R+
Sbjct: 724 ACSYGHYEVAELLVRH 739
Score = 40.8 bits (94), Expect = 0.004
Identities = 32/115 (27%), Positives = 53/115 (46%), Gaps = 4/115 (3%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH H ++ + + + LD G+T LH A GHL+ R+LL++G+D
Sbjct: 561 PLHVAA-ERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
Query: 77 ENRSGWTVLQ---EAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLLEKLRKAQD 128
+ G+T Q EAV E + DY+ + AG +++L +Q+
Sbjct: 620 ISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQN 674
Score = 40.4 bits (93), Expect = 0.005
Identities = 25/87 (28%), Positives = 40/87 (45%), Gaps = 1/87 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH +N E + G D+ D G PLH A + GH++ A +L+ + V
Sbjct: 840 PLHLAAGYNNLEVAEYLLEHG-ADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA 898
Query: 77 ENRSGWTVLQEAVSTRDLELVQLVLRY 103
++ +T L EA +L L+L +
Sbjct: 899 TDKWAFTPLHEAAQKGRTQLCALLLAH 925
Score = 35.8 bits (81), Expect = 0.12
Identities = 20/80 (25%), Positives = 37/80 (46%)
Query: 24 HNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWT 83
H + +++ + + ++ + + TPLH+A H + VL HGA + + G T
Sbjct: 534 HPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQT 593
Query: 84 VLQEAVSTRDLELVQLVLRY 103
L A L+ +L+L Y
Sbjct: 594 ALHRAALAGHLQTCRLLLSY 613
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/77 (31%), Positives = 34/77 (44%), Gaps = 1/77 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH + H ++ + + D TPLH A G + +LLAHGAD
Sbjct: 870 GLIPLHNAASYG-HVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGAD 928
Query: 74 VGRENRSGWTVLQEAVS 90
+N+ G T L A +
Sbjct: 929 PTMKNQEGQTPLDLATA 945
Score = 34.3 bits (77), Expect = 0.35
Identities = 22/72 (30%), Positives = 34/72 (47%)
Query: 30 LEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAV 89
+++ V A V+ + + R +PLH A G + LL GA+V + G L A
Sbjct: 198 VKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNAC 257
Query: 90 STRDLELVQLVL 101
S E+V L+L
Sbjct: 258 SFGHAEVVSLLL 269
Score = 34.3 bits (77), Expect = 0.35
Identities = 29/85 (34%), Positives = 34/85 (40%), Gaps = 2/85 (2%)
Query: 4 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLEC 63
AN AR G PLH H E+ + D D TPLH A G ++
Sbjct: 240 ANVHARDDG-GLIPLHNACSFG-HAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDV 297
Query: 64 ARVLLAHGADVGRENRSGWTVLQEA 88
VLL HGAD N G + L A
Sbjct: 298 CIVLLQHGADPNIRNTDGKSALDLA 322
Score = 32.3 bits (72), Expect = 1.3
Identities = 23/79 (29%), Positives = 35/79 (44%), Gaps = 1/79 (1%)
Query: 10 KGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLA 69
K G PLH + + E ++ G + +D TPLH A + +E +LL+
Sbjct: 398 KDKGGLVPLHNACSYGHYEVTELLLKHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLLLS 456
Query: 70 HGADVGRENRSGWTVLQEA 88
HGAD N G + + A
Sbjct: 457 HGADPTLVNCHGKSAVDMA 475
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 52.0 bits (123), Expect = 2e-06
Identities = 41/125 (32%), Positives = 58/125 (46%), Gaps = 11/125 (8%)
Query: 4 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLEC 63
ANA AR + PLH L H ++ K + + D G TPL A + GH E
Sbjct: 768 ANAGARNADQA-VPLH-LACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHEL 825
Query: 64 ARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLLEKL 123
+LL HGA + N G T L EAV + + +V+L+L + A + VL ++
Sbjct: 826 VALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHG---------ASVQVLNKRQ 876
Query: 124 RKAQD 128
R A D
Sbjct: 877 RTAVD 881
Score = 36.2 bits (82), Expect = 0.093
Identities = 29/108 (26%), Positives = 46/108 (42%), Gaps = 4/108 (3%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH L ++ + + + E D G TPLHLA T GH +C + L+ + +
Sbjct: 496 GATPLH-LACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE 554
Query: 74 VGR---ENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPV 118
R N G T L A +++ +L+ + RL P+
Sbjct: 555 SCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPL 602
Score = 35.4 bits (80), Expect = 0.16
Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 4/88 (4%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLD---PRGRTPLHLATTLGHLECARVLLAH 70
G PLH + H + K + V+ +LD +G TPLH+A G+ LL +
Sbjct: 529 GNTPLHLACTYG-HEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQN 587
Query: 71 GADVGRENRSGWTVLQEAVSTRDLELVQ 98
GA +NR T L+ A++++ L +++
Sbjct: 588 GASTEIQNRLKETPLKCALNSKILSVME 615
Score = 34.7 bits (78), Expect = 0.27
Identities = 23/76 (30%), Positives = 32/76 (42%)
Query: 45 DPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYR 104
D RG TPLH+A G +L++ GA V + G T L A + L+L Y+
Sbjct: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
Query: 105 DYQRVVKRLAGIPVLL 120
V P+ L
Sbjct: 520 ASAEVQDNNGNTPLHL 535
Score = 32.7 bits (73), Expect = 1.0
Identities = 19/69 (27%), Positives = 31/69 (44%)
Query: 33 EVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTR 92
+V A + + G +PLH+A G + +LL HGA+ G N L A
Sbjct: 729 KVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQG 788
Query: 93 DLELVQLVL 101
++V+ +L
Sbjct: 789 HFQVVKCLL 797
Score = 30.8 bits (68), Expect = 3.9
Identities = 24/90 (26%), Positives = 40/90 (44%), Gaps = 1/90 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH + ++ V G + + D G TPLHLA G+ +LL + A
Sbjct: 463 GHTPLHVAAVCGQASLIDLLVSKGAM-VNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
++ +G T L A + + V+ ++ Y
Sbjct: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYY 551
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 51.2 bits (121), Expect = 3e-06
Identities = 26/57 (45%), Positives = 36/57 (63%), Gaps = 1/57 (1%)
Query: 45 DPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVL 101
DP G +PLHLA GH++ R+LL G D+ R+ +SG T L EA E+V+L+L
Sbjct: 186 DPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLL 241
Score = 50.4 bits (119), Expect = 5e-06
Identities = 30/92 (32%), Positives = 45/92 (48%), Gaps = 1/92 (1%)
Query: 10 KGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLA 69
K +G PLHY W R ++ ++AG + G PLHLA GH + + +LL
Sbjct: 78 KDNKGMRPLHYAAWQGRKEPMKLVLKAGSA-VNIPSDEGHIPLHLAAQHGHYDVSEMLLQ 136
Query: 70 HGADVGRENRSGWTVLQEAVSTRDLELVQLVL 101
H ++ + SG T L A + +VQL+L
Sbjct: 137 HQSNPCMVDNSGKTPLDLACEFGRVGVVQLLL 168
>gi|14150169 acyl-coenzyme A binding domain containing 6 [Homo
sapiens]
Length = 282
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/78 (34%), Positives = 41/78 (52%)
Query: 25 NRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTV 84
N + K +++ VD+ D GR LH A GH E VLL H AD+ ++ G T
Sbjct: 169 NNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTA 228
Query: 85 LQEAVSTRDLELVQLVLR 102
L A + L++V+L+L+
Sbjct: 229 LHYASACEFLDIVELLLQ 246
Score = 36.2 bits (82), Expect = 0.093
Identities = 26/88 (29%), Positives = 41/88 (46%), Gaps = 2/88 (2%)
Query: 10 KGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLA 69
K EG+ LH+ H+EL + + DI D G+T LH A+ L+ +LL
Sbjct: 188 KDEEGRALLHWAC-DRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQ 246
Query: 70 HGADVGRENRSGWTVLQEAVSTRDLELV 97
GAD ++ G + +E + + LV
Sbjct: 247 SGADPTLRDQDG-CLPEEVTGCKTVSLV 273
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 51.2 bits (121), Expect = 3e-06
Identities = 35/99 (35%), Positives = 50/99 (50%), Gaps = 2/99 (2%)
Query: 4 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLEC 63
AN +AR G PLH NR + +E V+ G I+ + G TP+H+A +GHL
Sbjct: 368 ANPNAR-ALNGFTPLHIACKKNRIKVMELLVKYG-ASIQAITESGLTPIHVAAFMGHLNI 425
Query: 64 ARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLR 102
+LL +GA N G T L A +E+V+ +LR
Sbjct: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 464
Score = 42.7 bits (99), Expect = 0.001
Identities = 20/75 (26%), Positives = 41/75 (54%)
Query: 27 HRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQ 86
H L +E+ ++ +G T LH+A+ G E +VL+ GA++ ++++G+T L
Sbjct: 55 HVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 114
Query: 87 EAVSTRDLELVQLVL 101
A +++V+ +L
Sbjct: 115 MAAQENHIDVVKYLL 129
Score = 40.4 bits (93), Expect = 0.005
Identities = 27/107 (25%), Positives = 49/107 (45%), Gaps = 1/107 (0%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH N+ + + G + + +G TPLHLA+ GH + +LL GA+
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYG-AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 666
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLL 120
+ +SG T L A + + ++ ++ Q +L P+++
Sbjct: 667 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIV 713
Score = 39.7 bits (91), Expect = 0.008
Identities = 23/70 (32%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
Query: 35 RAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDL 94
R GQ+D + D G TPLH A GH + +LL GA + ++G + L A +
Sbjct: 267 RGGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 324
Query: 95 ELVQLVLRYR 104
E V+ +L+++
Sbjct: 325 ECVKHLLQHK 334
Score = 38.9 bits (89), Expect = 0.014
Identities = 23/57 (40%), Positives = 30/57 (52%)
Query: 47 RGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
RG T LH+A G +E R LL +GA V R T L A E+VQL+L++
Sbjct: 442 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Score = 37.7 bits (86), Expect = 0.032
Identities = 31/89 (34%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQ 107
G TPLH+A G++ A +LL GA V R+G T L A + +V+L+L R Q
Sbjct: 212 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLD-RGGQ 270
Query: 108 RVVKRLAGIPVLLEKLRKAQDFYVEMKWE 136
K G+ L R D VE+ E
Sbjct: 271 IDAKTRDGLTPLHCAARSGHDQVVELLLE 299
Score = 37.7 bits (86), Expect = 0.032
Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 11/83 (13%)
Query: 30 LEKEVRAGQVDIEQ--------LDPRGR---TPLHLATTLGHLECARVLLAHGADVGREN 78
L RAGQV++ + +D R R TPLH+A+ LG E ++LL H A
Sbjct: 447 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 506
Query: 79 RSGWTVLQEAVSTRDLELVQLVL 101
+G+T L + +++ ++L
Sbjct: 507 TNGYTPLHISAREGQVDVASVLL 529
Score = 37.4 bits (85), Expect = 0.042
Identities = 21/70 (30%), Positives = 33/70 (47%)
Query: 33 EVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTR 92
E G +DI + G LHLA GH+ + LL G+ V + G T L A
Sbjct: 28 EYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAG 87
Query: 93 DLELVQLVLR 102
E+V+++++
Sbjct: 88 QAEVVKVLVK 97
Score = 37.0 bits (84), Expect = 0.055
Identities = 20/57 (35%), Positives = 31/57 (54%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYR 104
G TPLH++ G ++ A VLL GA + G+T L A L++ +L+L+ R
Sbjct: 509 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 565
Score = 35.8 bits (81), Expect = 0.12
Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 11/88 (12%)
Query: 25 NRHRELEKEVRAGQVDIEQL-----------DPRGRTPLHLATTLGHLECARVLLAHGAD 73
N + L R GQVD+ + +G TPLH+A G L+ A++LL A
Sbjct: 508 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 567
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVL 101
++G T L A + ++ L+L
Sbjct: 568 ADSAGKNGLTPLHVAAHYDNQKVALLLL 595
Score = 35.8 bits (81), Expect = 0.12
Identities = 25/90 (27%), Positives = 40/90 (44%), Gaps = 1/90 (1%)
Query: 13 EGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGA 72
+G PLH L H ++ + +I G T LHLA + A +L HGA
Sbjct: 640 QGVTPLH-LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA 698
Query: 73 DVGRENRSGWTVLQEAVSTRDLELVQLVLR 102
D + G+T L A ++++V +L+
Sbjct: 699 DQDAHTKLGYTPLIVACHYGNVKMVNFLLK 728
Score = 35.4 bits (80), Expect = 0.16
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
G TPL +A G+++ LL GA+V + ++G+T L +A ++ ++L++
Sbjct: 707 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762
Score = 34.7 bits (78), Expect = 0.27
Identities = 20/73 (27%), Positives = 34/73 (46%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQ 107
G TPLH+A + + A +LL GA ++G+T L A +++ +L Y
Sbjct: 575 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 634
Query: 108 RVVKRLAGIPVLL 120
+V + P+ L
Sbjct: 635 NIVTKQGVTPLHL 647
Score = 34.3 bits (77), Expect = 0.35
Identities = 22/90 (24%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH + H E K + + ++ + T LH+A GH ++LL A+
Sbjct: 311 GLSPLH-MAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 369
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
+G+T L A +++++L+++Y
Sbjct: 370 PNARALNGFTPLHIACKKNRIKVMELLVKY 399
Score = 33.1 bits (74), Expect = 0.79
Identities = 26/95 (27%), Positives = 39/95 (41%), Gaps = 1/95 (1%)
Query: 10 KGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLA 69
K +G PLH + +E + G + + G +PLH+A H+EC + LL
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK-NGLSPLHMAAQGDHVECVKHLLQ 332
Query: 70 HGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYR 104
H A V T L A + +L+L R
Sbjct: 333 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 367
Score = 32.7 bits (73), Expect = 1.0
Identities = 17/38 (44%), Positives = 18/38 (47%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVL 85
G TPLH A GH VLL HGA +G T L
Sbjct: 740 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 777
Score = 32.3 bits (72), Expect = 1.3
Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 1/89 (1%)
Query: 13 EGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGA 72
+G LH + ++ V+ G +I G TPL++A H++ + LL +GA
Sbjct: 75 KGNTALHIASLAGQAEVVKVLVKEG-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 133
Query: 73 DVGRENRSGWTVLQEAVSTRDLELVQLVL 101
+ G+T L A+ + V ++L
Sbjct: 134 NQSTATEDGFTPLAVALQQGHNQAVAILL 162
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 51.2 bits (121), Expect = 3e-06
Identities = 35/99 (35%), Positives = 50/99 (50%), Gaps = 2/99 (2%)
Query: 4 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLEC 63
AN +AR G PLH NR + +E V+ G I+ + G TP+H+A +GHL
Sbjct: 389 ANPNAR-ALNGFTPLHIACKKNRIKVMELLVKYG-ASIQAITESGLTPIHVAAFMGHLNI 446
Query: 64 ARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLR 102
+LL +GA N G T L A +E+V+ +LR
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485
Score = 42.7 bits (99), Expect = 0.001
Identities = 20/75 (26%), Positives = 41/75 (54%)
Query: 27 HRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQ 86
H L +E+ ++ +G T LH+A+ G E +VL+ GA++ ++++G+T L
Sbjct: 76 HVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 135
Query: 87 EAVSTRDLELVQLVL 101
A +++V+ +L
Sbjct: 136 MAAQENHIDVVKYLL 150
Score = 40.4 bits (93), Expect = 0.005
Identities = 27/107 (25%), Positives = 49/107 (45%), Gaps = 1/107 (0%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH N+ + + G + + +G TPLHLA+ GH + +LL GA+
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYG-AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLL 120
+ +SG T L A + + ++ ++ Q +L P+++
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIV 734
Score = 39.7 bits (91), Expect = 0.008
Identities = 23/70 (32%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
Query: 35 RAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDL 94
R GQ+D + D G TPLH A GH + +LL GA + ++G + L A +
Sbjct: 288 RGGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 95 ELVQLVLRYR 104
E V+ +L+++
Sbjct: 346 ECVKHLLQHK 355
Score = 38.9 bits (89), Expect = 0.014
Identities = 23/57 (40%), Positives = 30/57 (52%)
Query: 47 RGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
RG T LH+A G +E R LL +GA V R T L A E+VQL+L++
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Score = 37.7 bits (86), Expect = 0.032
Identities = 31/89 (34%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQ 107
G TPLH+A G++ A +LL GA V R+G T L A + +V+L+L R Q
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLD-RGGQ 291
Query: 108 RVVKRLAGIPVLLEKLRKAQDFYVEMKWE 136
K G+ L R D VE+ E
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Score = 37.7 bits (86), Expect = 0.032
Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 11/83 (13%)
Query: 30 LEKEVRAGQVDIEQ--------LDPRGR---TPLHLATTLGHLECARVLLAHGADVGREN 78
L RAGQV++ + +D R R TPLH+A+ LG E ++LL H A
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 79 RSGWTVLQEAVSTRDLELVQLVL 101
+G+T L + +++ ++L
Sbjct: 528 TNGYTPLHISAREGQVDVASVLL 550
Score = 37.4 bits (85), Expect = 0.042
Identities = 21/70 (30%), Positives = 33/70 (47%)
Query: 33 EVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTR 92
E G +DI + G LHLA GH+ + LL G+ V + G T L A
Sbjct: 49 EYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAG 108
Query: 93 DLELVQLVLR 102
E+V+++++
Sbjct: 109 QAEVVKVLVK 118
Score = 37.0 bits (84), Expect = 0.055
Identities = 20/57 (35%), Positives = 31/57 (54%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYR 104
G TPLH++ G ++ A VLL GA + G+T L A L++ +L+L+ R
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 586
Score = 35.8 bits (81), Expect = 0.12
Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 11/88 (12%)
Query: 25 NRHRELEKEVRAGQVDIEQL-----------DPRGRTPLHLATTLGHLECARVLLAHGAD 73
N + L R GQVD+ + +G TPLH+A G L+ A++LL A
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 588
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVL 101
++G T L A + ++ L+L
Sbjct: 589 ADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Score = 35.8 bits (81), Expect = 0.12
Identities = 25/90 (27%), Positives = 40/90 (44%), Gaps = 1/90 (1%)
Query: 13 EGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGA 72
+G PLH L H ++ + +I G T LHLA + A +L HGA
Sbjct: 661 QGVTPLH-LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA 719
Query: 73 DVGRENRSGWTVLQEAVSTRDLELVQLVLR 102
D + G+T L A ++++V +L+
Sbjct: 720 DQDAHTKLGYTPLIVACHYGNVKMVNFLLK 749
Score = 35.4 bits (80), Expect = 0.16
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
G TPL +A G+++ LL GA+V + ++G+T L +A ++ ++L++
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Score = 34.7 bits (78), Expect = 0.27
Identities = 20/73 (27%), Positives = 34/73 (46%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQ 107
G TPLH+A + + A +LL GA ++G+T L A +++ +L Y
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655
Query: 108 RVVKRLAGIPVLL 120
+V + P+ L
Sbjct: 656 NIVTKQGVTPLHL 668
Score = 34.3 bits (77), Expect = 0.35
Identities = 22/90 (24%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH + H E K + + ++ + T LH+A GH ++LL A+
Sbjct: 332 GLSPLH-MAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
+G+T L A +++++L+++Y
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKY 420
Score = 33.1 bits (74), Expect = 0.79
Identities = 26/95 (27%), Positives = 39/95 (41%), Gaps = 1/95 (1%)
Query: 10 KGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLA 69
K +G PLH + +E + G + + G +PLH+A H+EC + LL
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK-NGLSPLHMAAQGDHVECVKHLLQ 353
Query: 70 HGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYR 104
H A V T L A + +L+L R
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 388
Score = 32.7 bits (73), Expect = 1.0
Identities = 17/38 (44%), Positives = 18/38 (47%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVL 85
G TPLH A GH VLL HGA +G T L
Sbjct: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Score = 32.3 bits (72), Expect = 1.3
Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 1/89 (1%)
Query: 13 EGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGA 72
+G LH + ++ V+ G +I G TPL++A H++ + LL +GA
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEG-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154
Query: 73 DVGRENRSGWTVLQEAVSTRDLELVQLVL 101
+ G+T L A+ + V ++L
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILL 183
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 51.2 bits (121), Expect = 3e-06
Identities = 35/99 (35%), Positives = 50/99 (50%), Gaps = 2/99 (2%)
Query: 4 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLEC 63
AN +AR G PLH NR + +E V+ G I+ + G TP+H+A +GHL
Sbjct: 389 ANPNAR-ALNGFTPLHIACKKNRIKVMELLVKYG-ASIQAITESGLTPIHVAAFMGHLNI 446
Query: 64 ARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLR 102
+LL +GA N G T L A +E+V+ +LR
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485
Score = 42.7 bits (99), Expect = 0.001
Identities = 20/75 (26%), Positives = 41/75 (54%)
Query: 27 HRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQ 86
H L +E+ ++ +G T LH+A+ G E +VL+ GA++ ++++G+T L
Sbjct: 76 HVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 135
Query: 87 EAVSTRDLELVQLVL 101
A +++V+ +L
Sbjct: 136 MAAQENHIDVVKYLL 150
Score = 40.4 bits (93), Expect = 0.005
Identities = 27/107 (25%), Positives = 49/107 (45%), Gaps = 1/107 (0%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH N+ + + G + + +G TPLHLA+ GH + +LL GA+
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYG-AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLL 120
+ +SG T L A + + ++ ++ Q +L P+++
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIV 734
Score = 39.7 bits (91), Expect = 0.008
Identities = 23/70 (32%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
Query: 35 RAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDL 94
R GQ+D + D G TPLH A GH + +LL GA + ++G + L A +
Sbjct: 288 RGGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 95 ELVQLVLRYR 104
E V+ +L+++
Sbjct: 346 ECVKHLLQHK 355
Score = 38.9 bits (89), Expect = 0.014
Identities = 23/57 (40%), Positives = 30/57 (52%)
Query: 47 RGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
RG T LH+A G +E R LL +GA V R T L A E+VQL+L++
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Score = 37.7 bits (86), Expect = 0.032
Identities = 31/89 (34%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQ 107
G TPLH+A G++ A +LL GA V R+G T L A + +V+L+L R Q
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLD-RGGQ 291
Query: 108 RVVKRLAGIPVLLEKLRKAQDFYVEMKWE 136
K G+ L R D VE+ E
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Score = 37.7 bits (86), Expect = 0.032
Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 11/83 (13%)
Query: 30 LEKEVRAGQVDIEQ--------LDPRGR---TPLHLATTLGHLECARVLLAHGADVGREN 78
L RAGQV++ + +D R R TPLH+A+ LG E ++LL H A
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 79 RSGWTVLQEAVSTRDLELVQLVL 101
+G+T L + +++ ++L
Sbjct: 528 TNGYTPLHISAREGQVDVASVLL 550
Score = 37.4 bits (85), Expect = 0.042
Identities = 21/70 (30%), Positives = 33/70 (47%)
Query: 33 EVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTR 92
E G +DI + G LHLA GH+ + LL G+ V + G T L A
Sbjct: 49 EYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAG 108
Query: 93 DLELVQLVLR 102
E+V+++++
Sbjct: 109 QAEVVKVLVK 118
Score = 37.0 bits (84), Expect = 0.055
Identities = 20/57 (35%), Positives = 31/57 (54%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYR 104
G TPLH++ G ++ A VLL GA + G+T L A L++ +L+L+ R
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 586
Score = 35.8 bits (81), Expect = 0.12
Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 11/88 (12%)
Query: 25 NRHRELEKEVRAGQVDIEQL-----------DPRGRTPLHLATTLGHLECARVLLAHGAD 73
N + L R GQVD+ + +G TPLH+A G L+ A++LL A
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 588
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVL 101
++G T L A + ++ L+L
Sbjct: 589 ADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Score = 35.8 bits (81), Expect = 0.12
Identities = 25/90 (27%), Positives = 40/90 (44%), Gaps = 1/90 (1%)
Query: 13 EGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGA 72
+G PLH L H ++ + +I G T LHLA + A +L HGA
Sbjct: 661 QGVTPLH-LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA 719
Query: 73 DVGRENRSGWTVLQEAVSTRDLELVQLVLR 102
D + G+T L A ++++V +L+
Sbjct: 720 DQDAHTKLGYTPLIVACHYGNVKMVNFLLK 749
Score = 35.4 bits (80), Expect = 0.16
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
G TPL +A G+++ LL GA+V + ++G+T L +A ++ ++L++
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Score = 34.7 bits (78), Expect = 0.27
Identities = 20/73 (27%), Positives = 34/73 (46%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQ 107
G TPLH+A + + A +LL GA ++G+T L A +++ +L Y
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655
Query: 108 RVVKRLAGIPVLL 120
+V + P+ L
Sbjct: 656 NIVTKQGVTPLHL 668
Score = 34.3 bits (77), Expect = 0.35
Identities = 22/90 (24%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G PLH + H E K + + ++ + T LH+A GH ++LL A+
Sbjct: 332 GLSPLH-MAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
+G+T L A +++++L+++Y
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKY 420
Score = 33.1 bits (74), Expect = 0.79
Identities = 26/95 (27%), Positives = 39/95 (41%), Gaps = 1/95 (1%)
Query: 10 KGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLA 69
K +G PLH + +E + G + + G +PLH+A H+EC + LL
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK-NGLSPLHMAAQGDHVECVKHLLQ 353
Query: 70 HGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYR 104
H A V T L A + +L+L R
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 388
Score = 32.7 bits (73), Expect = 1.0
Identities = 17/38 (44%), Positives = 18/38 (47%)
Query: 48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVL 85
G TPLH A GH VLL HGA +G T L
Sbjct: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Score = 32.3 bits (72), Expect = 1.3
Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 1/89 (1%)
Query: 13 EGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGA 72
+G LH + ++ V+ G +I G TPL++A H++ + LL +GA
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEG-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154
Query: 73 DVGRENRSGWTVLQEAVSTRDLELVQLVL 101
+ G+T L A+ + V ++L
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILL 183
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 50.8 bits (120), Expect = 4e-06
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 1/87 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH+ +NR +E ++ G D+ D G PLH A + GH E A +L+ HGA V
Sbjct: 529 PLHFAAGYNRVSVVEYLLQHG-ADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV 587
Query: 77 ENRSGWTVLQEAVSTRDLELVQLVLRY 103
+ +T L EA + E+ +L+L++
Sbjct: 588 ADLWKFTPLHEAAAKGKYEICKLLLQH 614
Score = 47.8 bits (112), Expect = 3e-05
Identities = 29/87 (33%), Positives = 44/87 (50%), Gaps = 1/87 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH +NR + ++ ++ G D+ D PLH A + GH E +L+ HGA V
Sbjct: 214 PLHLAAGYNRVKIVQLLLQHG-ADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNA 272
Query: 77 ENRSGWTVLQEAVSTRDLELVQLVLRY 103
+ +T L EA S +E+ L+L Y
Sbjct: 273 MDLWQFTPLHEAASKNRVEVCSLLLSY 299
Score = 47.8 bits (112), Expect = 3e-05
Identities = 27/76 (35%), Positives = 40/76 (52%), Gaps = 2/76 (2%)
Query: 45 DPRGR--TPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLR 102
D +GR TPLHLA +LE A LL HGADV +++ G L A S +++ L+++
Sbjct: 674 DTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIK 733
Query: 103 YRDYQRVVKRLAGIPV 118
Y + A P+
Sbjct: 734 YNACVNATDKWAFTPL 749
Score = 46.2 bits (108), Expect = 9e-05
Identities = 26/87 (29%), Positives = 44/87 (50%), Gaps = 1/87 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH+ R +E ++ G +++ D G PLH A + GH E +LL HGAD
Sbjct: 61 PLHFAAGFGRKDVVEYLLQNG-ANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
Query: 77 ENRSGWTVLQEAVSTRDLELVQLVLRY 103
+ +T L EA +++ ++L++
Sbjct: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQH 146
Score = 43.5 bits (101), Expect = 6e-04
Identities = 24/70 (34%), Positives = 37/70 (52%), Gaps = 1/70 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH + H ++ + V + + LD G+T LH A GHL+ R+LL++G D
Sbjct: 403 PLH-VASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 77 ENRSGWTVLQ 86
+ G+T LQ
Sbjct: 462 ISLQGFTALQ 471
Score = 43.1 bits (100), Expect = 8e-04
Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 4/103 (3%)
Query: 3 PANASARKGPEGKY--PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGH 60
P N + R +G++ PLH +N E ++ G D+ D G PLH A + GH
Sbjct: 667 PDNVNCRD-TQGRHSTPLHLAAGYNNLEVAEYLLQHG-ADVNAQDKGGLIPLHNAASYGH 724
Query: 61 LECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
++ A +L+ + A V ++ +T L EA +L L+L +
Sbjct: 725 VDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAH 767
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/91 (34%), Positives = 43/91 (47%), Gaps = 2/91 (2%)
Query: 10 KGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLA 69
K G PLH + + E V+ G V + D TPLH A G E ++LL
Sbjct: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAV-VNVADLWKFTPLHEAAAKGKYEICKLLLQ 613
Query: 70 HGADVGRENRSGWTVLQEAVSTRDLELVQLV 100
HGAD ++NR G T L + V D ++ L+
Sbjct: 614 HGADPTKKNRDGNTPL-DLVKDGDTDIQDLL 643
Score = 40.8 bits (94), Expect = 0.004
Identities = 30/103 (29%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query: 4 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAG---QVDIEQLDPRGRTPLHLATTLGH 60
A+ SA+ G+Y L+ R EK + V+ D R TPLHLA
Sbjct: 164 ADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNR 223
Query: 61 LECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
++ ++LL HGADV +++ L A S E+ +L++++
Sbjct: 224 VKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKH 266
Score = 40.4 bits (93), Expect = 0.005
Identities = 20/65 (30%), Positives = 33/65 (50%)
Query: 39 VDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQ 98
V+ ++ R TPLH A + LL HGADV +++ G L A S E+ +
Sbjct: 517 VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE 576
Query: 99 LVLRY 103
L++++
Sbjct: 577 LLVKH 581
Score = 38.5 bits (88), Expect = 0.019
Identities = 29/88 (32%), Positives = 39/88 (44%), Gaps = 12/88 (13%)
Query: 28 RELEKEVRAGQVD----------IEQLDPRGR--TPLHLATTLGHLECARVLLAHGADVG 75
REL + R G V+ + D GR TPLH A G + LL +GA+V
Sbjct: 26 RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ 85
Query: 76 RENRSGWTVLQEAVSTRDLELVQLVLRY 103
+ G L A S E+V L+LR+
Sbjct: 86 ARDDGGLIPLHNACSFGHAEVVNLLLRH 113
Score = 35.0 bits (79), Expect = 0.21
Identities = 20/45 (44%), Positives = 26/45 (57%), Gaps = 1/45 (2%)
Query: 50 TPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDL 94
TPLH A G + +LLAHGAD +N+ G T L + VS D+
Sbjct: 747 TPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL-DLVSADDV 790
Score = 33.5 bits (75), Expect = 0.60
Identities = 29/85 (34%), Positives = 34/85 (40%), Gaps = 2/85 (2%)
Query: 4 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLEC 63
AN AR G PLH + +R G D D TPLH A G ++
Sbjct: 82 ANVQARDDG-GLIPLHNACSFGHAEVVNLLLRHG-ADPNARDNWNYTPLHEAAIKGKIDV 139
Query: 64 ARVLLAHGADVGRENRSGWTVLQEA 88
VLL HGA+ N G T L A
Sbjct: 140 CIVLLQHGAEPTIRNTDGRTALDLA 164
Score = 33.5 bits (75), Expect = 0.60
Identities = 18/54 (33%), Positives = 27/54 (50%)
Query: 50 TPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
TPLH+A+ H + V++ H A V + G T L A L+ +L+L Y
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSY 455
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 50.4 bits (119), Expect = 5e-06
Identities = 27/95 (28%), Positives = 53/95 (55%), Gaps = 1/95 (1%)
Query: 9 RKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLL 68
++ G+ PLH +++++ + G ++ D G TPLH A +G+ + A++L+
Sbjct: 157 KRNERGETPLHMAAIRGDVKQVKELISLG-ANVNVKDFAGWTPLHEACNVGYYDVAKILI 215
Query: 69 AHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
A GADV + T L ++ S+ ++V+L+LR+
Sbjct: 216 AAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRH 250
Score = 41.6 bits (96), Expect = 0.002
Identities = 18/61 (29%), Positives = 38/61 (62%)
Query: 41 IEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLV 100
+ + + RG TPLH+A G ++ + L++ GA+V ++ +GWT L EA + ++ +++
Sbjct: 155 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 214
Query: 101 L 101
+
Sbjct: 215 I 215
Score = 32.7 bits (73), Expect = 1.0
Identities = 19/69 (27%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
Query: 29 ELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEA 88
++ K + A D+ TPLH + + GH + ++LL HG + + N+ G + +
Sbjct: 209 DVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPV-DV 267
Query: 89 VSTRDLELV 97
T +LEL+
Sbjct: 268 AETEELELL 276
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 50.4 bits (119), Expect = 5e-06
Identities = 27/95 (28%), Positives = 53/95 (55%), Gaps = 1/95 (1%)
Query: 9 RKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLL 68
++ G+ PLH +++++ + G ++ D G TPLH A +G+ + A++L+
Sbjct: 180 KRNERGETPLHMAAIRGDVKQVKELISLG-ANVNVKDFAGWTPLHEACNVGYYDVAKILI 238
Query: 69 AHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
A GADV + T L ++ S+ ++V+L+LR+
Sbjct: 239 AAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRH 273
Score = 41.6 bits (96), Expect = 0.002
Identities = 18/61 (29%), Positives = 38/61 (62%)
Query: 41 IEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLV 100
+ + + RG TPLH+A G ++ + L++ GA+V ++ +GWT L EA + ++ +++
Sbjct: 178 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 237
Query: 101 L 101
+
Sbjct: 238 I 238
Score = 32.7 bits (73), Expect = 1.0
Identities = 19/69 (27%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
Query: 29 ELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEA 88
++ K + A D+ TPLH + + GH + ++LL HG + + N+ G + +
Sbjct: 232 DVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPV-DV 290
Query: 89 VSTRDLELV 97
T +LEL+
Sbjct: 291 AETEELELL 299
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 49.7 bits (117), Expect = 8e-06
Identities = 28/88 (31%), Positives = 47/88 (53%), Gaps = 1/88 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G+ LH+ N H E+ + A +I D + R LH A +GHL+ +L+ HGA+
Sbjct: 115 GRTALHHAAL-NGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAE 173
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVL 101
V +++ G+T L A S + +V+ +L
Sbjct: 174 VTCKDKKGYTPLHAAASNGQINVVKHLL 201
Score = 47.4 bits (111), Expect = 4e-05
Identities = 24/64 (37%), Positives = 37/64 (57%)
Query: 40 DIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQL 99
D+ LD RTPLH+A LG E +L+ GA V ++ T L AV++R E VQ+
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 100 VLRY 103
++++
Sbjct: 68 LIKH 71
Score = 47.4 bits (111), Expect = 4e-05
Identities = 27/95 (28%), Positives = 51/95 (53%), Gaps = 1/95 (1%)
Query: 7 SARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARV 66
+A+ G +PLH L N H + +++ + +I+ D GRT LH A G++EC ++
Sbjct: 340 TAKCGIHSMFPLH-LAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKL 398
Query: 67 LLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVL 101
L + GAD ++++ G T L A + ++ ++
Sbjct: 399 LQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLV 433
Score = 46.6 bits (109), Expect = 7e-05
Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 2/97 (2%)
Query: 15 KYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADV 74
K PLH ++ H+ LE +++ VD++ D +GRT L LA GH EC L+ GA +
Sbjct: 543 KSPLHLAAYNGHHQALEVLLQS-LVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
Query: 75 -GRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVV 110
++N + T L +V ++L+L D V
Sbjct: 602 FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAV 638
Score = 43.1 bits (100), Expect = 8e-04
Identities = 25/88 (28%), Positives = 41/88 (46%), Gaps = 1/88 (1%)
Query: 13 EGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGA 72
+G PLH + H L +R D + PLHLA H +C R LL+ G
Sbjct: 313 DGNTPLHVAARYG-HELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGF 371
Query: 73 DVGRENRSGWTVLQEAVSTRDLELVQLV 100
++ ++ G T L A + ++E ++L+
Sbjct: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLL 399
Score = 42.7 bits (99), Expect = 0.001
Identities = 23/67 (34%), Positives = 31/67 (46%)
Query: 45 DPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYR 104
D +GRTPL A H+EC ++LL H A V + SG T L A V +++
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 105 DYQRVVK 111
VK
Sbjct: 871 QADLTVK 877
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 2/87 (2%)
Query: 17 PLHYLV--WHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADV 74
PLH V H L E+ ++ D +G+TPL LA GH++ +LL A+V
Sbjct: 612 PLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANV 671
Query: 75 GRENRSGWTVLQEAVSTRDLELVQLVL 101
+ G T L + T E VQ++L
Sbjct: 672 DTVDILGCTALHRGIMTGHEECVQMLL 698
Score = 40.8 bits (94), Expect = 0.004
Identities = 26/85 (30%), Positives = 41/85 (48%), Gaps = 1/85 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGR 76
PLH V +R E + + D+ D +TPLH+A ++CA V++ + V
Sbjct: 52 PLHRAV-ASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
Query: 77 ENRSGWTVLQEAVSTRDLELVQLVL 101
+R G T L A +E+V L+L
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLL 135
Score = 40.4 bits (93), Expect = 0.005
Identities = 22/64 (34%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 13 EGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGA 72
+GK PLH H R + ++ G +I+ +D G TPLH+A GH L GA
Sbjct: 280 DGKSPLHMTAVHGRFTRSQTLIQNGG-EIDCVDKDGNTPLHVAARYGHELLINTLRTSGA 338
Query: 73 DVGR 76
D +
Sbjct: 339 DTAK 342
Score = 38.5 bits (88), Expect = 0.019
Identities = 21/63 (33%), Positives = 30/63 (47%)
Query: 29 ELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEA 88
E K +++ D + D GRTPLH A H C L+ GA+V + G T L A
Sbjct: 394 ECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453
Query: 89 VST 91
++
Sbjct: 454 AAS 456
Score = 37.7 bits (86), Expect = 0.032
Identities = 23/82 (28%), Positives = 43/82 (52%), Gaps = 1/82 (1%)
Query: 10 KGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLA 69
K +G PLH + + ++ + G V+I++++ G T LH+A G L+
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLLNLG-VEIDEINVYGNTALHIACYNGQDAVVNELID 235
Query: 70 HGADVGRENRSGWTVLQEAVST 91
+GA+V + N +G+T L A ++
Sbjct: 236 YGANVNQPNNNGFTPLHFAAAS 257
Score = 37.0 bits (84), Expect = 0.055
Identities = 25/78 (32%), Positives = 38/78 (48%), Gaps = 6/78 (7%)
Query: 32 KEVRAGQVDIEQL------DPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVL 85
K V+ +V I L D GRT LH A GH+E +LLA GA++ ++ L
Sbjct: 93 KAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRAL 152
Query: 86 QEAVSTRDLELVQLVLRY 103
A L++V L++ +
Sbjct: 153 HWAAYMGHLDVVALLINH 170
Score = 35.0 bits (79), Expect = 0.21
Identities = 22/89 (24%), Positives = 41/89 (46%), Gaps = 1/89 (1%)
Query: 13 EGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGA 72
E + PLH + +E + +G + D TPLH A E +VL+ H A
Sbjct: 15 EKRTPLHVAAFLGDAEIIELLILSG-ARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSA 73
Query: 73 DVGRENRSGWTVLQEAVSTRDLELVQLVL 101
DV +++ T L A + + ++ ++++
Sbjct: 74 DVNARDKNWQTPLHVAAANKAVKCAEVII 102
Score = 33.5 bits (75), Expect = 0.60
Identities = 23/87 (26%), Positives = 39/87 (44%), Gaps = 3/87 (3%)
Query: 27 HRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHG---ADVGRENRSGWT 83
H E + + +V I D RGRTPLH A GH LL D ++ G+T
Sbjct: 690 HEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYT 749
Query: 84 VLQEAVSTRDLELVQLVLRYRDYQRVV 110
L A + ++++L + +++ +
Sbjct: 750 PLHWACYNGNENCIEVLLEQKCFRKFI 776
Score = 33.1 bits (74), Expect = 0.79
Identities = 28/96 (29%), Positives = 42/96 (43%), Gaps = 4/96 (4%)
Query: 10 KGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLA 69
K +G PLH+ ++ +E V Q + TPLH A H CA +LL
Sbjct: 743 KDNQGYTPLHWACYNGNENCIE--VLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLG 800
Query: 70 --HGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
+ V + G T L+ A +E +QL+LR+
Sbjct: 801 AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836
Score = 32.7 bits (73), Expect = 1.0
Identities = 27/80 (33%), Positives = 35/80 (43%), Gaps = 9/80 (11%)
Query: 30 LEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAV 89
LEKE VDI G T LH GH EC ++LL + ++ G T L A
Sbjct: 665 LEKEANVDTVDI-----LGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719
Query: 90 ----STRDLELVQLVLRYRD 105
+T EL+Q+ L D
Sbjct: 720 ARGHATWLSELLQMALSEED 739
Score = 32.3 bits (72), Expect = 1.3
Identities = 15/35 (42%), Positives = 21/35 (60%)
Query: 34 VRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLL 68
V + Q D+ D TPLHLA + GH +CA ++L
Sbjct: 867 VNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 49.7 bits (117), Expect = 8e-06
Identities = 33/93 (35%), Positives = 46/93 (49%), Gaps = 3/93 (3%)
Query: 10 KGPEGKYPLHYLVWHNRHRELEKEVRAGQ-VDIEQLDPRGRTPLHLATTLGHLECARVLL 68
K G PLHY W R + +RA V+ LD G+ PLHLA GH E + +LL
Sbjct: 78 KDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLD--GQIPLHLAAQYGHYEVSEMLL 135
Query: 69 AHGADVGRENRSGWTVLQEAVSTRDLELVQLVL 101
H ++ N++ T L A L++ QL+L
Sbjct: 136 QHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLL 168
Score = 44.7 bits (104), Expect = 3e-04
Identities = 25/57 (43%), Positives = 33/57 (57%), Gaps = 1/57 (1%)
Query: 45 DPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVL 101
DP TPLHLA GH E R LL G ++ R+ ++G T L EA E+V+L+L
Sbjct: 186 DPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLL 241
Score = 37.7 bits (86), Expect = 0.032
Identities = 31/93 (33%), Positives = 41/93 (44%), Gaps = 6/93 (6%)
Query: 12 PEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHG 71
P PLH L N HRE+ +++ ++I + G T LH A G E R+LL G
Sbjct: 187 PNYTTPLH-LAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGG 244
Query: 72 ADVGRENRSGWTVL----QEAVSTRDLELVQLV 100
DV N T L Q S E+ QL+
Sbjct: 245 VDVNIRNTYNQTALDIVNQFTTSQASREIKQLL 277
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 49.7 bits (117), Expect = 8e-06
Identities = 33/103 (32%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Query: 1 MIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGH 60
M+ +R G LH V+ + + + +G DI+Q+ G T LH+AT GH
Sbjct: 88 MLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSG-ADIQQVGYGGLTALHIATIAGH 146
Query: 61 LECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
LE A VLL HGA+V ++ +T L A ++ +L+L++
Sbjct: 147 LEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKF 189
Score = 34.3 bits (77), Expect = 0.35
Identities = 19/52 (36%), Positives = 27/52 (51%)
Query: 50 TPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVL 101
TPLH+A GH + R+LL GADV G L A + L + +L++
Sbjct: 169 TPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLM 220
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 49.7 bits (117), Expect = 8e-06
Identities = 33/103 (32%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Query: 1 MIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGH 60
M+ +R G LH V+ + + + +G DI+Q+ G T LH+AT GH
Sbjct: 189 MLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSG-ADIQQVGYGGLTALHIATIAGH 247
Query: 61 LECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
LE A VLL HGA+V ++ +T L A ++ +L+L++
Sbjct: 248 LEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKF 290
Score = 34.3 bits (77), Expect = 0.35
Identities = 19/52 (36%), Positives = 27/52 (51%)
Query: 50 TPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVL 101
TPLH+A GH + R+LL GADV G L A + L + +L++
Sbjct: 270 TPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLM 321
>gi|56090539 dysferlin-interacting protein 1 [Homo sapiens]
Length = 154
Score = 49.7 bits (117), Expect = 8e-06
Identities = 25/70 (35%), Positives = 40/70 (57%), Gaps = 3/70 (4%)
Query: 24 HNRHRELEKE---VRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRS 80
H R +LE+ +R +V + + P G LH A G+LEC ++L+ +GAD+ + + +
Sbjct: 37 HIRQGDLEQVGRFIRTRKVSLATIHPSGLAALHEAVLSGNLECVKLLVKYGADIHQRDEA 96
Query: 81 GWTVLQEAVS 90
GWT L A S
Sbjct: 97 GWTPLHIACS 106
Score = 39.3 bits (90), Expect = 0.011
Identities = 26/70 (37%), Positives = 35/70 (50%), Gaps = 1/70 (1%)
Query: 12 PEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHG 71
P G LH V ++ V+ G DI Q D G TPLH+A + G+ + AR L++ G
Sbjct: 62 PSGLAALHEAVLSGNLECVKLLVKYG-ADIHQRDEAGWTPLHIACSDGYPDIARYLISLG 120
Query: 72 ADVGRENRSG 81
AD N G
Sbjct: 121 ADRDATNDDG 130
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 49.3 bits (116), Expect = 1e-05
Identities = 25/88 (28%), Positives = 50/88 (56%), Gaps = 1/88 (1%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAD 73
G+ LH+ + H E+ K + + +I D + R +H A +GH+E ++L++HGA+
Sbjct: 140 GRTALHHAAFSG-HGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE 198
Query: 74 VGRENRSGWTVLQEAVSTRDLELVQLVL 101
V +++ +T L A S+ + +V+ +L
Sbjct: 199 VTCKDKKSYTPLHAAASSGMISVVKYLL 226
Score = 48.9 bits (115), Expect = 1e-05
Identities = 24/58 (41%), Positives = 35/58 (60%), Gaps = 1/58 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADV 74
PLH +H H+ LE V++ +D++ + GRTPL LA GH+EC VL+ GA +
Sbjct: 553 PLHLAAYHGHHQALEVLVQS-LLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI 609
Score = 47.8 bits (112), Expect = 3e-05
Identities = 27/86 (31%), Positives = 42/86 (48%), Gaps = 1/86 (1%)
Query: 17 PLHYLVWHNRHRELEKEVRA-GQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVG 75
PLH V ++ E + G + D +GRTPLH A H+EC ++LL+H A V
Sbjct: 791 PLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850
Query: 76 RENRSGWTVLQEAVSTRDLELVQLVL 101
+ +G T L A V++++
Sbjct: 851 SVDSTGKTPLMMAAENGQTNTVEMLV 876
Score = 47.0 bits (110), Expect = 5e-05
Identities = 29/84 (34%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 7 SARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARV 66
+A++G G +PLH K + +G DI+ D GRT LH A G+LEC +
Sbjct: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSG-FDIDTPDDFGRTCLHAAAAGGNLECLNL 423
Query: 67 LLAHGADVGRENRSGWTVLQEAVS 90
LL GAD ++++ G + L A +
Sbjct: 424 LLNTGADFNKKDKFGRSPLHYAAA 447
Score = 46.6 bits (109), Expect = 7e-05
Identities = 25/72 (34%), Positives = 34/72 (47%), Gaps = 1/72 (1%)
Query: 10 KGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLA 69
K +GK PLH H R + +++G V I+ D G TPLH+A GH L+
Sbjct: 302 KSKDGKTPLHMTALHGRFSRSQTIIQSGAV-IDCEDKNGNTPLHIAARYGHELLINTLIT 360
Query: 70 HGADVGRENRSG 81
GAD + G
Sbjct: 361 SGADTAKRGIHG 372
Score = 41.2 bits (95), Expect = 0.003
Identities = 27/74 (36%), Positives = 39/74 (52%), Gaps = 3/74 (4%)
Query: 33 EVRA---GQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAV 89
EVRA + D+ D RTPLH A LG E +L+ GA V ++ T L AV
Sbjct: 23 EVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAV 82
Query: 90 STRDLELVQLVLRY 103
++ E VQ++L++
Sbjct: 83 ASCSEEAVQVLLKH 96
Score = 40.0 bits (92), Expect = 0.006
Identities = 24/65 (36%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 39 VDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQ 98
VDI+ D G+TPL L+ GH +C LL GA+V +++ G T L T E V
Sbjct: 646 VDIQ--DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVD 703
Query: 99 LVLRY 103
+L++
Sbjct: 704 ALLQH 708
Score = 38.9 bits (89), Expect = 0.014
Identities = 22/73 (30%), Positives = 38/73 (52%), Gaps = 2/73 (2%)
Query: 14 GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGH-LECARVLLAHGA 72
G PLH ++ + + + + G + + Q + +G TPLH A H C +L+ +GA
Sbjct: 239 GNTPLHVACYNGQDVVVNELIDCGAI-VNQKNEKGFTPLHFAAASTHGALCLELLVGNGA 297
Query: 73 DVGRENRSGWTVL 85
DV +++ G T L
Sbjct: 298 DVNMKSKDGKTPL 310
Score = 37.7 bits (86), Expect = 0.032
Identities = 24/70 (34%), Positives = 31/70 (44%), Gaps = 1/70 (1%)
Query: 3 PANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLE 62
P NA + G+ PL V N H + + +++ D GRT LH GH E
Sbjct: 642 PQNAVDIQDGNGQTPLMLSVL-NGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEE 700
Query: 63 CARVLLAHGA 72
C LL HGA
Sbjct: 701 CVDALLQHGA 710
Score = 37.0 bits (84), Expect = 0.055
Identities = 20/62 (32%), Positives = 34/62 (54%)
Query: 40 DIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQL 99
D+ D +TPLH+A ++CA L+ ++V +R+G T L A + E+V+L
Sbjct: 99 DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKL 158
Query: 100 VL 101
+L
Sbjct: 159 LL 160
Score = 35.8 bits (81), Expect = 0.12
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 9 RKGPEGKYPLHYLVWHNRHRELEKEVRAGQ-VDIEQLDPRGRTPLHLATTLGHLECARVL 67
+K +G PLH+ + H L E+ G D+ G+TPLH+ G ++ +
Sbjct: 267 QKNEKGFTPLHFAA-ASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTI 325
Query: 68 LAHGADVGRENRSGWTVLQEA 88
+ GA + E+++G T L A
Sbjct: 326 IQSGAVIDCEDKNGNTPLHIA 346
Score = 35.0 bits (79), Expect = 0.21
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 4/68 (5%)
Query: 45 DPRGRTPLHLATTLGHLECARVLLAHGADV----GRENRSGWTVLQEAVSTRDLELVQLV 100
D RGRTP+HL+ GH+ LL A + + G+T L A V+L+
Sbjct: 716 DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
Query: 101 LRYRDYQR 108
L +Q+
Sbjct: 776 LEQEVFQK 783
Score = 34.7 bits (78), Expect = 0.27
Identities = 23/89 (25%), Positives = 41/89 (46%), Gaps = 1/89 (1%)
Query: 13 EGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGA 72
E + PLH + +E + +G + D + TPLH A E +VLL H A
Sbjct: 40 EKRTPLHAAAYLGDAEIIELLILSG-ARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSA 98
Query: 73 DVGRENRSGWTVLQEAVSTRDLELVQLVL 101
DV +++ T L A + + ++ + ++
Sbjct: 99 DVNARDKNWQTPLHIAAANKAVKCAEALV 127
Score = 34.7 bits (78), Expect = 0.27
Identities = 18/59 (30%), Positives = 32/59 (54%)
Query: 45 DPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
D GRT LH A GH E ++LL+ GA++ ++ + A +E+V+L++ +
Sbjct: 137 DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195
Score = 32.7 bits (73), Expect = 1.0
Identities = 21/64 (32%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 40 DIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQ-EAVSTRDLELVQ 98
D + D GR+PLH A + +C L+ GA V + G T L A S D + ++
Sbjct: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLE 489
Query: 99 LVLR 102
+LR
Sbjct: 490 YLLR 493
Score = 32.0 bits (71), Expect = 1.8
Identities = 19/62 (30%), Positives = 29/62 (46%)
Query: 27 HRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQ 86
H E+ K + + ++ D + TPLH A + G + + LL G D+ N G T L
Sbjct: 185 HIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLH 244
Query: 87 EA 88
A
Sbjct: 245 VA 246
Score = 32.0 bits (71), Expect = 1.8
Identities = 18/53 (33%), Positives = 28/53 (52%)
Query: 39 VDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVST 91
VD+ + + G TPLH+A G L+ GA V ++N G+T L A ++
Sbjct: 230 VDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAAS 282
Score = 31.6 bits (70), Expect = 2.3
Identities = 12/22 (54%), Positives = 16/22 (72%)
Query: 49 RTPLHLATTLGHLECARVLLAH 70
RTP+H A T GH EC R+L+ +
Sbjct: 618 RTPIHAAATNGHSECLRLLIGN 639
Score = 30.4 bits (67), Expect = 5.1
Identities = 18/52 (34%), Positives = 26/52 (50%)
Query: 50 TPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVL 101
+PLHLA GH + VL+ D+ N SG T L A +E V +++
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLI 603
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,985,221
Number of Sequences: 37866
Number of extensions: 1339865
Number of successful extensions: 17980
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 396
Number of HSP's successfully gapped in prelim test: 218
Number of HSP's that attempted gapping in prelim test: 14432
Number of HSP's gapped (non-prelim): 3273
length of query: 626
length of database: 18,247,518
effective HSP length: 108
effective length of query: 518
effective length of database: 14,157,990
effective search space: 7333838820
effective search space used: 7333838820
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.