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Search of human proteins with 38348406
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38348406 leucine rich repeat containing 33 [Homo sapiens]
(692 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38348406 leucine rich repeat containing 33 [Homo sapiens] 1394 0.0
gi|193083139 leucine rich repeat containing 32 precursor [Homo s... 311 2e-84
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap... 311 2e-84
gi|225579152 insulin-like growth factor binding protein, acid la... 111 3e-24
gi|4826772 insulin-like growth factor binding protein, acid labi... 111 3e-24
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 111 3e-24
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 105 1e-22
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 100 3e-21
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 100 5e-21
gi|194440719 chondroadherin-like [Homo sapiens] 100 5e-21
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 98 2e-20
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 95 2e-19
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 95 2e-19
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 94 4e-19
gi|45505137 podocan [Homo sapiens] 92 2e-18
gi|188528675 slit homolog 1 [Homo sapiens] 91 5e-18
gi|4507531 toll-like receptor 3 [Homo sapiens] 88 2e-17
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 88 2e-17
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 88 3e-17
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 88 3e-17
gi|11321571 slit homolog 3 [Homo sapiens] 87 4e-17
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 86 1e-16
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 85 2e-16
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 85 2e-16
gi|20302168 toll-like receptor 8 [Homo sapiens] 84 3e-16
gi|7706093 toll-like receptor 7 [Homo sapiens] 84 4e-16
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 83 7e-16
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 83 7e-16
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 83 7e-16
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens] 83 1e-15
>gi|38348406 leucine rich repeat containing 33 [Homo sapiens]
Length = 692
Score = 1394 bits (3608), Expect = 0.0
Identities = 692/692 (100%), Positives = 692/692 (100%)
Query: 1 MELLPLWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHAR 60
MELLPLWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHAR
Sbjct: 1 MELLPLWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHAR 60
Query: 61 MLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSEN 120
MLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSEN
Sbjct: 61 MLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSEN 120
Query: 121 YEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGL 180
YEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGL
Sbjct: 121 YEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGL 180
Query: 181 ERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEW 240
ERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEW
Sbjct: 181 ERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEW 240
Query: 241 FLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMV 300
FLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMV
Sbjct: 241 FLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMV 300
Query: 301 AQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLH 360
AQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLH
Sbjct: 301 AQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLH 360
Query: 361 QNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPG 420
QNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPG
Sbjct: 361 QNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPG 420
Query: 421 LFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDC 480
LFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDC
Sbjct: 421 LFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDC 480
Query: 481 PFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRD 540
PFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRD
Sbjct: 481 PFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRD 540
Query: 541 LDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCG 600
LDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCG
Sbjct: 541 LDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCG 600
Query: 601 VDGWGALQHGQTVADWAMVTCNLSSKIIRVTELPGGVPRDCKWERLDLGLLYLVLILPSC 660
VDGWGALQHGQTVADWAMVTCNLSSKIIRVTELPGGVPRDCKWERLDLGLLYLVLILPSC
Sbjct: 601 VDGWGALQHGQTVADWAMVTCNLSSKIIRVTELPGGVPRDCKWERLDLGLLYLVLILPSC 660
Query: 661 LTLLVACTVIVLTFKKPLLQVIKSRCHWSSVY 692
LTLLVACTVIVLTFKKPLLQVIKSRCHWSSVY
Sbjct: 661 LTLLVACTVIVLTFKKPLLQVIKSRCHWSSVY 692
>gi|193083139 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 311 bits (796), Expect = 2e-84
Identities = 242/653 (37%), Positives = 325/653 (49%), Gaps = 43/653 (6%)
Query: 34 CKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHL 93
CK+V C+ L VPS LPP L L N L+++ L Y L L L + +
Sbjct: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
Query: 94 ERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALML 153
+ GAFQ HL L L N L+ +A L LP + LDLSGN+L + +L
Sbjct: 86 SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 145
Query: 154 QNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLA 213
SL ++SLA N++ RL F + L +LDL N + +IE GAF+GL L HLNL+
Sbjct: 146 GEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLS 205
Query: 214 FNNLPCIVDFGLTRLRVLNVSYNVLEWF-LATGGEAAFELETLDLSHNQLLFFPLLPQYS 272
N+L CI DF L +LRVL++S N +E F A+ +A F+L LDL N+LL FP L
Sbjct: 206 RNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALP 265
Query: 273 KLRTLLLRDNNM----GFYRDLYNTSSPREMVAQFLL--VDGNVTNITTVSLWEEFSSSD 326
+L L L +N + G +D +P E + L GN S
Sbjct: 266 RLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNA------------SGRP 313
Query: 327 LADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHN 386
L+ L LD+S N+ + +PD FL + SL LNL +NCL T R L LDLSHN
Sbjct: 314 LSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHN 373
Query: 387 QLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAA 446
L L L A LGSLR L N L +PP FAN ++ L++ N++S C P
Sbjct: 374 ALETLELG---ARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGP-- 428
Query: 447 SDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWG--VLNGSLA 504
D GP CV F + SLRSLSL + L F T LT LDLSSN G V G+L
Sbjct: 429 -DEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALG 487
Query: 505 PLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLD 564
L+ L+VL+L+ GL + +D F L+ L+L+ N L+ P + +++LE LD
Sbjct: 488 GLE---ASLEVLALQGNGL--MVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLD 542
Query: 565 LRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGA--LQHGQTVADWAM-VTC 621
LR NS + LP A+ L LR +YL NP CCG +GW A L G+ D + C
Sbjct: 543 LRNNSFSLLPGSAMG-GLETSLRRLYLQGNPLSCCG-NGWLAAQLHQGRVDVDATQDLIC 600
Query: 622 NLSSKIIRVTELPGGVPRDCKWERLD----LGLLYLVLILPSCLTLLVACTVI 670
SS+ L P DC+ L + +L +L+ LT L AC +
Sbjct: 601 RFSSQ--EEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCV 651
>gi|5031707 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 311 bits (796), Expect = 2e-84
Identities = 242/653 (37%), Positives = 325/653 (49%), Gaps = 43/653 (6%)
Query: 34 CKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHL 93
CK+V C+ L VPS LPP L L N L+++ L Y L L L + +
Sbjct: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
Query: 94 ERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALML 153
+ GAFQ HL L L N L+ +A L LP + LDLSGN+L + +L
Sbjct: 86 SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 145
Query: 154 QNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLA 213
SL ++SLA N++ RL F + L +LDL N + +IE GAF+GL L HLNL+
Sbjct: 146 GEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLS 205
Query: 214 FNNLPCIVDFGLTRLRVLNVSYNVLEWF-LATGGEAAFELETLDLSHNQLLFFPLLPQYS 272
N+L CI DF L +LRVL++S N +E F A+ +A F+L LDL N+LL FP L
Sbjct: 206 RNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALP 265
Query: 273 KLRTLLLRDNNM----GFYRDLYNTSSPREMVAQFLL--VDGNVTNITTVSLWEEFSSSD 326
+L L L +N + G +D +P E + L GN S
Sbjct: 266 RLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNA------------SGRP 313
Query: 327 LADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHN 386
L+ L LD+S N+ + +PD FL + SL LNL +NCL T R L LDLSHN
Sbjct: 314 LSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHN 373
Query: 387 QLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAA 446
L L L A LGSLR L N L +PP FAN ++ L++ N++S C P
Sbjct: 374 ALETLELG---ARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGP-- 428
Query: 447 SDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWG--VLNGSLA 504
D GP CV F + SLRSLSL + L F T LT LDLSSN G V G+L
Sbjct: 429 -DEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALG 487
Query: 505 PLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLD 564
L+ L+VL+L+ GL + +D F L+ L+L+ N L+ P + +++LE LD
Sbjct: 488 GLE---ASLEVLALQGNGL--MVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLD 542
Query: 565 LRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGA--LQHGQTVADWAM-VTC 621
LR NS + LP A+ L LR +YL NP CCG +GW A L G+ D + C
Sbjct: 543 LRNNSFSLLPGSAMG-GLETSLRRLYLQGNPLSCCG-NGWLAAQLHQGRVDVDATQDLIC 600
Query: 622 NLSSKIIRVTELPGGVPRDCKWERLD----LGLLYLVLILPSCLTLLVACTVI 670
SS+ L P DC+ L + +L +L+ LT L AC +
Sbjct: 601 RFSSQ--EEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCV 651
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 111 bits (277), Expect = 3e-24
Identities = 142/493 (28%), Positives = 196/493 (39%), Gaps = 54/493 (10%)
Query: 133 GLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNY 192
G + L L GN L+ A QNLSSL ++L G + L+ GLE L L L+RN
Sbjct: 113 GTQALWLDGNNLSSVPPAAF-QNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQ 171
Query: 193 IFEIEGGAFDGLAELRHLNLAFNNLPCIVDF---GLTRLRVLNVSYNVLEWFLATGGEAA 249
+ + G F L L L+ N L + D GL L LN+ +N L
Sbjct: 172 LRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL 231
Query: 250 FELETLDLSHNQLLFFP--LLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVD 307
L L L+ N+L + L ++LR L L N + + PR Q L +D
Sbjct: 232 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPR---LQKLYLD 288
Query: 308 GNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTL 367
N+ + L LR+LD+S N+ L + + L L L N + +L
Sbjct: 289 RNLIAAVAPGAF-----LGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 343
Query: 368 HIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARN 427
R + L EL L HN++ +L A LG L + L NQL V G F N
Sbjct: 344 RPRTFKDLHFLEELQLGHNRIRQL--AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN 401
Query: 428 ITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTS- 486
+ +++S N + P FR + L SL LEG LG + F G S
Sbjct: 402 VAVMNLSGNCLRNLPEQV------------FRGLGKLHSLHLEGSCLGRIRPHTFTGLSG 449
Query: 487 LTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGN 546
L L L N G++ L +A +L++ N H F G G L L LS N
Sbjct: 450 LRRLFLKDN-GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRL--FQGLGKLEYLLLSRN 506
Query: 547 CLTTFPR--FGGSLALETLDLRRNSLTALPQKAVSEQLSR-------------------G 585
L P G LD+ N L ALP ++ L R G
Sbjct: 507 RLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAP-LGRLRYLSLRNNSLRTFTPQPPG 565
Query: 586 LRTIYLSQNPYDC 598
L ++L NP+DC
Sbjct: 566 LERLWLEGNPWDC 578
Score = 107 bits (268), Expect = 3e-23
Identities = 138/501 (27%), Positives = 200/501 (39%), Gaps = 58/501 (11%)
Query: 43 CRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQ 102
C ++L +P +P + L LD N L ++ + Q L L+L L + A
Sbjct: 98 CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 157
Query: 103 ----------EQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALM 152
E+ LRSL LG + T P L L LS N L+ + +
Sbjct: 158 GLENLCHLHLERNQLRSLALG------TFAHT-------PALASLGLSNNRLSR-LEDGL 203
Query: 153 LQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNL 212
+ L SL ++L N++ L D+ F GL LREL L N + ++ F GLAELR L+L
Sbjct: 204 FEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDL 263
Query: 213 AFNNLPCI---VDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQL--LFFPL 267
+ N L I V L RL+ L + N++ L LDLSHN++ L
Sbjct: 264 SRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDT 323
Query: 268 LPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDL 327
P LR L L N + R T + + L + + E S L
Sbjct: 324 FPGLLGLRVLRLSHNAIASLRP--RTFKDLHFLEELQLGHNRIRQLA------ERSFEGL 375
Query: 328 ADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQ 387
L L + NQ Q + G + +++ +NL NCL L + G L L L +
Sbjct: 376 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 435
Query: 388 LSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAAS 447
L + P + L LR L N L+G+ + LD++ NQ++ P
Sbjct: 436 LGRIR--PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRL-- 491
Query: 448 DRVGPPSCVDFRNMASLRSLSLEGCGLGALP-DCPFQGTSLTYLDLSSN--WGVLNGSLA 504
F+ + L L L L LP D +LD+S N + N LA
Sbjct: 492 ----------FQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 541
Query: 505 PLQDVAPMLQVLSLRNMGLHS 525
PL L+ LSLRN L +
Sbjct: 542 PL----GRLRYLSLRNNSLRT 558
Score = 53.5 bits (127), Expect = 6e-07
Identities = 74/250 (29%), Positives = 92/250 (36%), Gaps = 52/250 (20%)
Query: 375 PGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMS 434
PG L L N LS + P L SL NL QL + P N+ L +
Sbjct: 111 PGGTQALWLDGNNLSSV--PPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 168
Query: 435 HNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSS 494
NQ+ L F + +L SL L L L D F+G + DL+
Sbjct: 169 RNQLRSLALGT------------FAHTPALASLGLSNNRLSRLEDGLFEGLGSLW-DLNL 215
Query: 495 NWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALD----FSGFGNLRDLDLSGNCL-- 548
W SLA L D A + SLR + L + +A FSG LR+LDLS N L
Sbjct: 216 GWN----SLAVLPDAA-FRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRA 270
Query: 549 ------TTFPR------------------FGGSLALETLDLRRNSLTALPQKAVSEQLSR 584
PR F G AL LDL N + L + L
Sbjct: 271 IKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLL-- 328
Query: 585 GLRTIYLSQN 594
GLR + LS N
Sbjct: 329 GLRVLRLSHN 338
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 111 bits (277), Expect = 3e-24
Identities = 142/493 (28%), Positives = 196/493 (39%), Gaps = 54/493 (10%)
Query: 133 GLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNY 192
G + L L GN L+ A QNLSSL ++L G + L+ GLE L L L+RN
Sbjct: 75 GTQALWLDGNNLSSVPPAAF-QNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQ 133
Query: 193 IFEIEGGAFDGLAELRHLNLAFNNLPCIVDF---GLTRLRVLNVSYNVLEWFLATGGEAA 249
+ + G F L L L+ N L + D GL L LN+ +N L
Sbjct: 134 LRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL 193
Query: 250 FELETLDLSHNQLLFFP--LLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVD 307
L L L+ N+L + L ++LR L L N + + PR Q L +D
Sbjct: 194 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPR---LQKLYLD 250
Query: 308 GNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTL 367
N+ + L LR+LD+S N+ L + + L L L N + +L
Sbjct: 251 RNLIAAVAPGAF-----LGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 305
Query: 368 HIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARN 427
R + L EL L HN++ +L A LG L + L NQL V G F N
Sbjct: 306 RPRTFKDLHFLEELQLGHNRIRQL--AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN 363
Query: 428 ITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTS- 486
+ +++S N + P FR + L SL LEG LG + F G S
Sbjct: 364 VAVMNLSGNCLRNLPEQV------------FRGLGKLHSLHLEGSCLGRIRPHTFTGLSG 411
Query: 487 LTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGN 546
L L L N G++ L +A +L++ N H F G G L L LS N
Sbjct: 412 LRRLFLKDN-GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRL--FQGLGKLEYLLLSRN 468
Query: 547 CLTTFPR--FGGSLALETLDLRRNSLTALPQKAVSEQLSR-------------------G 585
L P G LD+ N L ALP ++ L R G
Sbjct: 469 RLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAP-LGRLRYLSLRNNSLRTFTPQPPG 527
Query: 586 LRTIYLSQNPYDC 598
L ++L NP+DC
Sbjct: 528 LERLWLEGNPWDC 540
Score = 107 bits (268), Expect = 3e-23
Identities = 138/501 (27%), Positives = 200/501 (39%), Gaps = 58/501 (11%)
Query: 43 CRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQ 102
C ++L +P +P + L LD N L ++ + Q L L+L L + A
Sbjct: 60 CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 119
Query: 103 ----------EQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALM 152
E+ LRSL LG + T P L L LS N L+ + +
Sbjct: 120 GLENLCHLHLERNQLRSLALG------TFAHT-------PALASLGLSNNRLSR-LEDGL 165
Query: 153 LQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNL 212
+ L SL ++L N++ L D+ F GL LREL L N + ++ F GLAELR L+L
Sbjct: 166 FEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDL 225
Query: 213 AFNNLPCI---VDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQL--LFFPL 267
+ N L I V L RL+ L + N++ L LDLSHN++ L
Sbjct: 226 SRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDT 285
Query: 268 LPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDL 327
P LR L L N + R T + + L + + E S L
Sbjct: 286 FPGLLGLRVLRLSHNAIASLRP--RTFKDLHFLEELQLGHNRIRQLA------ERSFEGL 337
Query: 328 ADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQ 387
L L + NQ Q + G + +++ +NL NCL L + G L L L +
Sbjct: 338 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 397
Query: 388 LSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAAS 447
L + P + L LR L N L+G+ + LD++ NQ++ P
Sbjct: 398 LGRIR--PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRL-- 453
Query: 448 DRVGPPSCVDFRNMASLRSLSLEGCGLGALP-DCPFQGTSLTYLDLSSN--WGVLNGSLA 504
F+ + L L L L LP D +LD+S N + N LA
Sbjct: 454 ----------FQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 503
Query: 505 PLQDVAPMLQVLSLRNMGLHS 525
PL L+ LSLRN L +
Sbjct: 504 PL----GRLRYLSLRNNSLRT 520
Score = 53.5 bits (127), Expect = 6e-07
Identities = 74/250 (29%), Positives = 92/250 (36%), Gaps = 52/250 (20%)
Query: 375 PGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMS 434
PG L L N LS + P L SL NL QL + P N+ L +
Sbjct: 73 PGGTQALWLDGNNLSSV--PPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 130
Query: 435 HNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSS 494
NQ+ L F + +L SL L L L D F+G + DL+
Sbjct: 131 RNQLRSLALGT------------FAHTPALASLGLSNNRLSRLEDGLFEGLGSLW-DLNL 177
Query: 495 NWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALD----FSGFGNLRDLDLSGNCL-- 548
W SLA L D A + SLR + L + +A FSG LR+LDLS N L
Sbjct: 178 GWN----SLAVLPDAA-FRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRA 232
Query: 549 ------TTFPR------------------FGGSLALETLDLRRNSLTALPQKAVSEQLSR 584
PR F G AL LDL N + L + L
Sbjct: 233 IKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLL-- 290
Query: 585 GLRTIYLSQN 594
GLR + LS N
Sbjct: 291 GLRVLRLSHN 300
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 111 bits (277), Expect = 3e-24
Identities = 127/470 (27%), Positives = 193/470 (41%), Gaps = 66/470 (14%)
Query: 3 LLPLWLCLGF-HFLTVGWRNRSGTATAASQGVCKL----VGGAADCRGQSLASVPSSLPP 57
L LWLC G + G A C + +ADC L++VP L P
Sbjct: 7 LRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDP 66
Query: 58 HARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCL 117
L L N L L LE L L HL I AF L+ L+L +N L
Sbjct: 67 LTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 126
Query: 118 SENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVF 177
+ A L L SL+S+ L N I + + F
Sbjct: 127 G----------------------------GIPAEALWELPSLQSLRLDANLISLVPERSF 158
Query: 178 EGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFG---LTRLRVLNVS 234
EGL LR L L N + EI A + L L+ + LA N + I D+ LT L VL++
Sbjct: 159 EGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLH 218
Query: 235 YNVLEWFLATGGEAAFELETLDLSHNQLLFFPL-LPQYSKLRTLLLRDNN---------M 284
N ++ E LETLDL++N+L FP+ + +L+ L +NN M
Sbjct: 219 NNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFM 278
Query: 285 G--FYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLR------FLDMS 336
G + ++ +P + V + + + T+SL + DL+ L ++
Sbjct: 279 GNPLLQTIHFYDNPIQFVGRSAFQ--YLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLT 336
Query: 337 QNQFQYLPDGFLRKMPSLSHLNLHQNC---LMTLHIREHEPPGALTELDLSHNQLSELHL 393
+ + LP G +++P L L L N L +LH + L E+ L HN++ E+
Sbjct: 337 RAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQK-----LEEIGLQHNRIWEI-- 389
Query: 394 APGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPL 443
S L SL+ +LS N + + P F+ ++ LD++ NQ++ PL
Sbjct: 390 GADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPL 439
Score = 66.6 bits (161), Expect = 7e-11
Identities = 116/457 (25%), Positives = 173/457 (37%), Gaps = 90/457 (19%)
Query: 186 LDLQRNYIFEIEGGAFDGLAELRHLNLAFNNL---PCIVDFGLTRLRVLNVSYNVLEWFL 242
LDL N + E++ G F L L L L+ N+L P GL L++L + N L
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 243 ATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQ 302
A EA +EL +L L+P+ R SS R +
Sbjct: 131 A---EALWELPSLQSLRLDANLISLVPE-----------------RSFEGLSSLRHL--- 167
Query: 303 FLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQN 362
L D +T I +L ++L L+ + ++ N+ ++PD + + SL L+LH N
Sbjct: 168 -WLDDNALTEIPVRAL------NNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN 220
Query: 363 CLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLF 422
+ L E L LDL++N+L E +A LG L+ +N + +P F
Sbjct: 221 RIQHLGTHSFEGLHNLETLDLNYNKLQEFPVA---IRTLGRLQELGFHNNNIKAIPEKAF 277
Query: 423 ANARNITTLDMSHNQISLCPLPA-----------ASDRVGPPSCVDFRNMASLRSLSLEG 471
+ T+ N I A + + D + SL L+L
Sbjct: 278 MGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTR 337
Query: 472 CGLGALPDCPFQGTS-LTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLH------ 524
G+ LP Q L L+LS N ++++ + + L +GL
Sbjct: 338 AGIRLLPSGMCQQLPRLRVLELSHN---------QIEELPSLHRCQKLEEIGLQHNRIWE 388
Query: 525 ---------SSFMALD-------------FSGFGNLRDLDLSGNCLTTFPRFGGSLALET 562
SS ALD FS +L LDL+ N LTT P G L
Sbjct: 389 IGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP-LAGLGGLMH 447
Query: 563 LDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCC 599
L L+ N AL Q A S+ LR + + Y CC
Sbjct: 448 LKLKGN--LALSQ-AFSKDSFPKLRILEVPY-AYQCC 480
Score = 61.6 bits (148), Expect = 2e-09
Identities = 75/264 (28%), Positives = 112/264 (42%), Gaps = 47/264 (17%)
Query: 352 PSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLA-SCLGSLRLFNLS 410
P ++L+L N L L L EL LS N LS + PG A S L SL++ L
Sbjct: 66 PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHI---PGQAFSGLYSLKILMLQ 122
Query: 411 SNQLLGVPPGLFANARNITTLDMSHNQISLCP------------LPAASDRVGPPSCVDF 458
+NQL G+P ++ +L + N ISL P L + +
Sbjct: 123 NNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRAL 182
Query: 459 RNMASLRSLSLEGCGLGALPDCPFQG-TSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLS 517
N+ +L++++L + +PD FQ TSL L L +N
Sbjct: 183 NNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN---------------------R 221
Query: 518 LRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLA-LETLDLRRNSLTALPQK 576
++++G HS F G NL LDL+ N L FP +L L+ L N++ A+P+K
Sbjct: 222 IQHLGTHS------FEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEK 275
Query: 577 AVSEQLSRGLRTIYLSQNPYDCCG 600
A + L+TI+ NP G
Sbjct: 276 AFMG--NPLLQTIHFYDNPIQFVG 297
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 105 bits (263), Expect = 1e-22
Identities = 116/421 (27%), Positives = 173/421 (41%), Gaps = 51/421 (12%)
Query: 42 DCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAF 101
DC L+ +PS+L L L N + L + L LE L L L I +GAF
Sbjct: 51 DCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAF 110
Query: 102 QEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRS 161
L+ L+L +N L E LQNL SL+S
Sbjct: 111 TGLYSLKVLMLQNNQLRHVPTEA----------------------------LQNLRSLQS 142
Query: 162 VSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIV 221
+ L N I + S F GL LR L L N + EI AF L+ L+ + LA N + I
Sbjct: 143 LRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIP 202
Query: 222 DF---GLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFP-LLPQYSKLRTL 277
D+ L+ L VL++ N + + LETLDL++N L FP + S L+ L
Sbjct: 203 DYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKEL 262
Query: 278 LLRDNNMGFYRDLYNTSSPREMVAQFL--------------LVDGNVTNITTVSLWEEFS 323
NN+ + +P + F L + + S EF
Sbjct: 263 GFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFP 322
Query: 324 S-SDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELD 382
+ A+L L ++ Q LP ++P+L L+L N L L L ++D
Sbjct: 323 DLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDL--PSFSVCQKLQKID 380
Query: 383 LSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCP 442
L HN++ E+ + L SLR NL+ N++ + P F+ ++ LD+S N +S P
Sbjct: 381 LRHNEIYEIKV--DTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFP 438
Query: 443 L 443
+
Sbjct: 439 I 439
Score = 73.6 bits (179), Expect = 6e-13
Identities = 111/430 (25%), Positives = 175/430 (40%), Gaps = 58/430 (13%)
Query: 209 HLNLAFNNLPCIVDFGLTRLRVLN---VSYNVLEWFLATGGEAAFELETLDLSHNQLLFF 265
+L+L+ NN+ ++ L LR L ++ N L + + L+ L L +NQL
Sbjct: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
Query: 266 PL--LPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFS 323
P L L++L L N++ + + S + L D +T I + F
Sbjct: 130 PTEALQNLRSLQSLRLDANHISYVPP--SCFSGLHSLRHLWLDDNALTEIPV----QAFR 183
Query: 324 SSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDL 383
S L+ L+ + ++ N+ ++PD + SL L+LH N + +L + + +L LDL
Sbjct: 184 S--LSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDL 241
Query: 384 SHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLC-- 441
++N L E P L +L+ SN + +P F ++ T+ N I
Sbjct: 242 NYNNLDEF---PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGR 298
Query: 442 ------------PLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPF-QGTSLT 488
L AS P D A+L SL+L G + +LP Q +L
Sbjct: 299 SAFQHLPELRTLTLNGASQITEFP---DLTGTANLESLTLTGAQISSLPQTVCNQLPNLQ 355
Query: 489 YLDLSSNWGVLNGSLAPLQD---------------VAPMLQVLSLRNMGLHSSFMAL--- 530
LDLS N S + Q V Q+LSLR++ L + +A+
Sbjct: 356 VLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHP 415
Query: 531 -DFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTI 589
FS +L LDLS N L++FP G L L L N Q +S + L+ I
Sbjct: 416 NAFSTLPSLIKLDLSSNLLSSFP-ITGLHGLTHLKLTGNHAL---QSLISSENFPELKVI 471
Query: 590 YLSQNPYDCC 599
+ Y CC
Sbjct: 472 EMPY-AYQCC 480
Score = 63.2 bits (152), Expect = 8e-10
Identities = 80/275 (29%), Positives = 116/275 (42%), Gaps = 39/275 (14%)
Query: 381 LDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISL 440
LDLS N +S+L P L L L+ N L +P G F ++ L + +NQ+
Sbjct: 71 LDLSMNNISQL--LPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRH 128
Query: 441 CPLPAASD--------------RVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTS 486
P A + PPSC F + SLR L L+ L +P F+ S
Sbjct: 129 VPTEALQNLRSLQSLRLDANHISYVPPSC--FSGLHSLRHLWLDDNALTEIPVQAFRSLS 186
Query: 487 -LTYLDLSSNWGVLNGSLAPLQDVA----PMLQVLSLRNMGLHSSFMALDFSGFGNLRDL 541
L + L+ N + + D A L VL L N +HS F G +L L
Sbjct: 187 ALQAMTLALN------KIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKC-FDGLHSLETL 239
Query: 542 DLSGNCLTTFPRFGGSLA-LETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCG 600
DL+ N L FP +L+ L+ L N++ ++P+KA S L TI+ NP
Sbjct: 240 DLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPS--LITIHFYDNPIQFV- 296
Query: 601 VDGWGALQHGQTVADWAMVTCNLSSKIIRVTELPG 635
G A QH + + +T N +S+I +L G
Sbjct: 297 --GRSAFQH---LPELRTLTLNGASQITEFPDLTG 326
Score = 43.5 bits (101), Expect = 7e-04
Identities = 44/155 (28%), Positives = 67/155 (43%), Gaps = 11/155 (7%)
Query: 83 LESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGN 142
LESL+L + + + + +L+ L L N L E + L+++DL N
Sbjct: 330 LESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLL-----EDLPSFSVCQKLQKIDLRHN 384
Query: 143 ALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFD 202
+ E + Q L SLRS++LA N I + + F L L +LDL N +
Sbjct: 385 EIYE-IKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSF---PIT 440
Query: 203 GLAELRHLNLAFNNL--PCIVDFGLTRLRVLNVSY 235
GL L HL L N+ I L+V+ + Y
Sbjct: 441 GLHGLTHLKLTGNHALQSLISSENFPELKVIEMPY 475
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 100 bits (250), Expect = 3e-21
Identities = 107/386 (27%), Positives = 175/386 (45%), Gaps = 37/386 (9%)
Query: 82 LLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSG 141
++ + L +L + G F L L L N LS + + L++L + L L
Sbjct: 15 IISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL---KILMLQN 71
Query: 142 NALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAF 201
N L + A L L SL+S+ L N I + + FEGL LR L L N + EI A
Sbjct: 72 NQLG-GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRAL 130
Query: 202 DGLAELRHLNLAFNNLPCIVDFG---LTRLRVLNVSYNVLEWFLATGGEAAFELETLDLS 258
+ L L+ + LA N + I D+ LT L VL++ N ++ E LETLDL+
Sbjct: 131 NNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLN 190
Query: 259 HNQLLFFPL-LPQYSKLRTLLLRDNN---------MG--FYRDLYNTSSPREMVAQFLLV 306
+N+L FP+ + +L+ L +NN MG + ++ +P + V +
Sbjct: 191 YNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQ 250
Query: 307 DGNVTNITTVSLWEEFSSSDLADLR------FLDMSQNQFQYLPDGFLRKMPSLSHLNLH 360
+ + T+SL + DL+ L +++ + LP G +++P L L L
Sbjct: 251 --YLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 308
Query: 361 QNC---LMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGV 417
N L +LH + L E+ L HN++ E+ S L SL+ +LS N + +
Sbjct: 309 HNQIEELPSLHRCQK-----LEEIGLQHNRIWEI--GADTFSQLSSLQALDLSWNAIRSI 361
Query: 418 PPGLFANARNITTLDMSHNQISLCPL 443
P F+ ++ LD++ NQ++ PL
Sbjct: 362 HPEAFSTLHSLVKLDLTDNQLTTLPL 387
Score = 72.8 bits (177), Expect = 1e-12
Identities = 107/430 (24%), Positives = 163/430 (37%), Gaps = 83/430 (19%)
Query: 164 LAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDF 223
L+ N + L +F L L EL L N++ I G AF GL L+ L L N L I
Sbjct: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP-- 78
Query: 224 GLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNN 283
EA +EL +L L+P+
Sbjct: 79 ----------------------AEALWELPSLQSLRLDANLISLVPE------------- 103
Query: 284 MGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYL 343
R SS R + L D +T I +L ++L L+ + ++ N+ ++
Sbjct: 104 ----RSFEGLSSLRHL----WLDDNALTEIPVRAL------NNLPALQAMTLALNRISHI 149
Query: 344 PDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGS 403
PD + + SL L+LH N + L E L LDL++N+L E P LG
Sbjct: 150 PDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF---PVAIRTLGR 206
Query: 404 LRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCP------LP-----AASDRVGP 452
L+ +N + +P F + T+ N I LP + + +
Sbjct: 207 LQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDI 266
Query: 453 PSCVDFRNMASLRSLSLEGCGLGALPD--CPFQGTSLTYLDLSSNWGVLNGSLAPLQDVA 510
D + SL L+L G+ LP C Q L L+LS N ++++
Sbjct: 267 QEFPDLKGTTSLEILTLTRAGIRLLPSGMCQ-QLPRLRVLELSHN---------QIEELP 316
Query: 511 PMLQVLSLRNMGLHSSFM----ALDFSGFGNLRDLDLSGNCLTTF--PRFGGSLALETLD 564
+ + L +GL + + A FS +L+ LDLS N + + F +L LD
Sbjct: 317 SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLD 376
Query: 565 LRRNSLTALP 574
L N LT LP
Sbjct: 377 LTDNQLTTLP 386
Score = 51.6 bits (122), Expect = 2e-06
Identities = 83/365 (22%), Positives = 132/365 (36%), Gaps = 100/365 (27%)
Query: 57 PHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNC 116
P + +TL N + + +++ Q L L LH+ ++ + +F+
Sbjct: 134 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFE-------------- 179
Query: 117 LSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSV 176
L L LDL+ N L E A ++ L L+ + N I + +
Sbjct: 180 -------------GLHNLETLDLNYNKLQEFPVA--IRTLGRLQELGFHNNNIKAIPEKA 224
Query: 177 FEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDF----GLTRLRVLN 232
F G L+ + N I + AF L +L L+L N I +F G T L +L
Sbjct: 225 FMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL--NGAMDIQEFPDLKGTTSLEILT 282
Query: 233 VSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYN 292
++ + + + L L+LSHNQ+ P L + KL + L+ N
Sbjct: 283 LTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNR--------- 333
Query: 293 TSSPREMVAQFLLVDGNVTNITTVSLWE--EFSSSDLADLRFLDMSQNQFQYLPDGFLRK 350
+WE + S L+ L+ LD+S N +
Sbjct: 334 -------------------------IWEIGADTFSQLSSLQALDLSWNAIR--------- 359
Query: 351 MPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLS 410
++H TLH +L +LDL+ NQL+ L LA LG L L
Sbjct: 360 -------SIHPEAFSTLH--------SLVKLDLTDNQLTTLPLAG-----LGGLMHLKLK 399
Query: 411 SNQLL 415
N L
Sbjct: 400 GNLAL 404
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 100 bits (249), Expect = 5e-21
Identities = 119/394 (30%), Positives = 171/394 (43%), Gaps = 43/394 (10%)
Query: 224 GLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFP--LLPQYSKLRTLLLRD 281
G+T L+ L +S + + +L+TL LS N++ P LL + L L L
Sbjct: 72 GMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDH 131
Query: 282 NNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQ 341
N + R + + + Q L ++ N + SL+ ++L +L+ LD+S N
Sbjct: 132 NAL---RGIDQNMFQKLVNLQELALNQNQLDFLPASLF-----TNLENLKLLDLSGNNLT 183
Query: 342 YLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCL 401
+LP G L L L LH N L++L GALTEL N + +APG L
Sbjct: 184 HLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRS--IAPGAFDRL 241
Query: 402 GSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNM 461
+L LS N L +P LF ++ N+T L + N ++ P V F M
Sbjct: 242 PNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELP------------GVLFGEM 289
Query: 462 ASLRSLSLEGCGLGALPDCPFQGTS-LTYLDLSSNWGVLNGSLAPLQDVA----PMLQVL 516
L+ L L L LP F+ S L YL ++ L+ L+ L A LQVL
Sbjct: 290 GGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVT-----LSPRLSALPQGAFQGLGELQVL 344
Query: 517 SLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPR--FGGSLALETLDLRRNSLTALP 574
+L + GL + L G G LR + L N L PR F +LE++ L N L LP
Sbjct: 345 ALHSNGLTALPDGL-LRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLP 403
Query: 575 QKAVSEQLSRGLRTIYLSQNPYDC-CGVD---GW 604
V L R L + L N + C CG+ GW
Sbjct: 404 GD-VFGALPR-LTEVLLGHNSWRCDCGLGPFLGW 435
Score = 80.1 bits (196), Expect = 6e-15
Identities = 95/335 (28%), Positives = 131/335 (39%), Gaps = 36/335 (10%)
Query: 60 RMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSE 119
+ L L N + L L LLE L L L I + FQ+ +L+ L L N L
Sbjct: 101 KTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDF 160
Query: 120 NYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEG 179
A+ L L+ LDLSGN LT + +L + L + L N ++ LD +
Sbjct: 161 L---PASLFTNLENLKLLDLSGNNLTH-LPKGLLGAQAKLERLLLHSNRLVSLDSGLLNS 216
Query: 180 LERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNN---LPCIVDFGLTRLRVLNVSYN 236
L L EL RN+I I GAFD L L L L+ N+ LP + L +L + N
Sbjct: 217 LGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFEN 276
Query: 237 VLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSP 296
L L+ L L+ QL P N+ R L T SP
Sbjct: 277 PLAELPGVLFGEMGGLQELWLNRTQLRTLP-----------AAAFRNLSRLRYLGVTLSP 325
Query: 297 REMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSH 356
R +S + + L +L+ L + N LPDG LR + L
Sbjct: 326 R------------------LSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQ 367
Query: 357 LNLHQNCLMTLHIREHEPPGALTELDLSHNQLSEL 391
++L +N L L +L + L HNQL L
Sbjct: 368 VSLRRNRLRALPRALFRNLSSLESVQLDHNQLETL 402
Score = 51.2 bits (121), Expect = 3e-06
Identities = 64/248 (25%), Positives = 95/248 (38%), Gaps = 55/248 (22%)
Query: 42 DCRGQSLASVPSSL---PPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISR 98
D G +L +P L L L +N L +L + L L L H H+ I+
Sbjct: 176 DLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAP 235
Query: 99 GAFQEQGHLRSLVLGDNCLSENYEETAAALHA---------------LPG---------- 133
GAF +L SL L N L+ + +A LH+ LPG
Sbjct: 236 GAFDRLPNLSSLTLSRNHLA--FLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQ 293
Query: 134 -------------------LRRLDLSGNALTEDMAAL---MLQNLSSLRSVSLAGNTIMR 171
L RL G L+ ++AL Q L L+ ++L N +
Sbjct: 294 ELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTA 353
Query: 172 LDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFN---NLPCIVDFGLTRL 228
L D + GL +LR++ L+RN + + F L+ L + L N LP V L RL
Sbjct: 354 LPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRL 413
Query: 229 RVLNVSYN 236
+ + +N
Sbjct: 414 TEVLLGHN 421
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 100 bits (249), Expect = 5e-21
Identities = 90/267 (33%), Positives = 123/267 (46%), Gaps = 31/267 (11%)
Query: 43 CRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQ 102
CR Q+L VP ++P + L L N LK + + Q P L L L C +E ++ GAF+
Sbjct: 48 CRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFR 107
Query: 103 EQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSV 162
G L L L N L E +E AL L LRRL+L GNAL E++ L +L ++
Sbjct: 108 GLGRLLLLNLASNHLRELPQE---ALDGLGSLRRLELEGNAL-EELRPGTFGALGALATL 163
Query: 163 SLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVD 222
+LA N ++ L F+GL R+R L L N + + A GL LR L+L N L +
Sbjct: 164 NLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPG 223
Query: 223 FGLTRLR---VLNVSYNVLEW--------------------FLATGGEAAF----ELETL 255
L++ R L + +N L + L G AF L TL
Sbjct: 224 PVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTL 283
Query: 256 DLSHNQLLFFPLLPQYSKLRTLLLRDN 282
DL NQL P L +LR L L+ N
Sbjct: 284 DLRGNQLDTLPPLQGPGQLRRLRLQGN 310
Score = 76.6 bits (187), Expect = 7e-14
Identities = 80/281 (28%), Positives = 110/281 (39%), Gaps = 37/281 (13%)
Query: 33 VCKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCH 92
VC + C G L +VP P ++L L N ++ + L SL L C
Sbjct: 401 VCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCG 460
Query: 93 LERISRGAFQEQGHLRSLVLGDNCLS---------------------ENYEETAAALHAL 131
+ + GA G L L L DN L+ + AAL AL
Sbjct: 461 IAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRAL 520
Query: 132 PGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRN 191
P L L L NA+ + +A L +LR V L+GN I + L +L L RN
Sbjct: 521 PSLFSLHLQDNAV-DRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRN 579
Query: 192 YIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGG----- 246
+ E+ GA +GL L L L+ N L + D V ++ FL + G
Sbjct: 580 QLREVPTGALEGLPALLELQLSGNPLRALRDGAFQ-----PVGRSLQHLFLNSSGLEQIC 634
Query: 247 EAAFE-----LETLDLSHNQLLFFPLLPQYSKLRTLLLRDN 282
AF L++L L NQL P LP S+L + L N
Sbjct: 635 PGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSN 675
Score = 68.2 bits (165), Expect = 2e-11
Identities = 80/285 (28%), Positives = 116/285 (40%), Gaps = 23/285 (8%)
Query: 287 YRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDG 346
Y++L + Q L + GN+ + + ++ + L LD+ + + + +G
Sbjct: 50 YQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQ-----GVPHLTHLDLRHCEVELVAEG 104
Query: 347 FLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRL 406
R + L LNL N L L + G+L L+L N L EL PG LG+L
Sbjct: 105 AFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELR--PGTFGALGALAT 162
Query: 407 FNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRS 466
NL+ N L+ +P F + L +SHN +S+ A + + +LR
Sbjct: 163 LNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALA------------GLPALRR 210
Query: 467 LSLEGCGLGALPDCPF-QGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHS 525
LSL L ALP Q L L+L N G L P L+ L L + G
Sbjct: 211 LSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGL--ALPGLREL-LLDGGALQ 267
Query: 526 SFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLDLRRNSL 570
+ F+ L LDL GN L T P G L L L+ N L
Sbjct: 268 ALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPL 312
Score = 64.3 bits (155), Expect = 4e-10
Identities = 79/258 (30%), Positives = 113/258 (43%), Gaps = 19/258 (7%)
Query: 186 LDLQRNYIFEIEGGAFDGLAELRHLNL---AFNNLPCIVDFGLTRLRVLNVSYNVLEWFL 242
LDL+RN+ + AF GL L L+L L GL RL L +S N L
Sbjct: 430 LDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLS 489
Query: 243 ATGGEAAFELETLDLSHNQLLFFP--LLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMV 300
A E A L L L N+ L P L L +L L+DN + L R
Sbjct: 490 AAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVD---RLAPGDLGRTRA 546
Query: 301 AQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLH 360
+++ + GN IT VSL + +L L + +NQ + +P G L +P+L L L
Sbjct: 547 LRWVYLSGN--RITEVSLG---ALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLS 601
Query: 361 QNCLMTLHIREHEPPG-ALTELDLSHNQLSELHLAPGLASCLG-SLRLFNLSSNQLLGVP 418
N L L +P G +L L L+ + L + + PG S LG L+ +L NQL +P
Sbjct: 602 GNPLRALRDGAFQPVGRSLQHLFLNSSGLEQ--ICPGAFSGLGPGLQSLHLQKNQLRALP 659
Query: 419 PGLFANARNITTLDMSHN 436
+ + +D+S N
Sbjct: 660 --ALPSLSQLELIDLSSN 675
Score = 61.6 bits (148), Expect = 2e-09
Identities = 149/557 (26%), Positives = 200/557 (35%), Gaps = 114/557 (20%)
Query: 60 RMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSE 119
R L L N L L +L P L LSLH L+ + + L L LG N L+
Sbjct: 185 RWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTY 244
Query: 120 NYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEG 179
EE AL PGLR L L G AL L F
Sbjct: 245 AGEEDGLAL---PGLRELLLDGGAL-------------------------QALGPRAFAH 276
Query: 180 LERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPC------IVDFGLTRLRVLN- 232
RL LDL+ N + + G +LR L L N L C ++++ L R RV +
Sbjct: 277 CPRLHTLDLRGNQLDTLP--PLQGPGQLRRLRLQGNPLWCGCQARPLLEW-LARARVRSD 333
Query: 233 -----------VSYNVLE-WFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLR 280
+ + L W L G+AA E E L+ + + P P R
Sbjct: 334 GACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELE---ERAVAGPRAPPRGPPR----- 385
Query: 281 DNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQF 340
G + PR V + ++ F S D + LD+ +N F
Sbjct: 386 ----GPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPS----DTQLLDLRRNHF 437
Query: 341 QYLPDGFLRKMPSLSHL-NLH-QNC-LMTLHIREHEPPGALTELDLSHNQLSELHLA--- 394
+P P L HL +LH Q+C + L G L L LS NQL+ L A
Sbjct: 438 PSVPRA---AFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALE 494
Query: 395 ------------------PGLA-SCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSH 435
PG A L SL +L N + + PG R + + +S
Sbjct: 495 GAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSG 554
Query: 436 NQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQG-TSLTYLDLSS 494
N+I+ L A +GP L L L+ L +P +G +L L LS
Sbjct: 555 NRITEVSLGA----LGP--------ARELEKLHLDRNQLREVPTGALEGLPALLELQLSG 602
Query: 495 N--WGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFG-NLRDLDLSGNCLTTF 551
N + +G+ P V LQ L L + GL FSG G L+ L L N L
Sbjct: 603 NPLRALRDGAFQP---VGRSLQHLFLNSSGLEQICPGA-FSGLGPGLQSLHLQKNQLRAL 658
Query: 552 PRFGGSLALETLDLRRN 568
P LE +DL N
Sbjct: 659 PALPSLSQLELIDLSSN 675
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 98.2 bits (243), Expect = 2e-20
Identities = 126/470 (26%), Positives = 192/470 (40%), Gaps = 74/470 (15%)
Query: 3 LLPLWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHARML 62
LL LWL L L + + A C G + DC G+ LA++P LP R L
Sbjct: 18 LLLLWLLL----LRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSL 73
Query: 63 TLDANPLKTLWNHSLQPYPLLESLSLHSCHLERI-SRGAFQEQGHLRSLVLGDNCLSENY 121
L N L + + P L+ + L++ L + S GA H+ SL L N +
Sbjct: 74 NLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGA--ASSHVVSLFLQHNKIR--- 128
Query: 122 EETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLE 181
+ L A L LDLS N +TE + + ++ ++LAGN I L+ F+GL
Sbjct: 129 SVEGSQLKAYLSLEVLDLSLNNITE-VRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLS 187
Query: 182 ------------------------RLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNL 217
RL +LDL RN I IEG F GL L L L NN+
Sbjct: 188 RSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNI 247
Query: 218 PCIVD---FGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKL 274
+ D +GL+++ VL++ YN L + L L LS+N +
Sbjct: 248 SKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSI------------ 295
Query: 275 RTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLD 334
+ F + L+ E+V F N+T + +E S ++L+ L L
Sbjct: 296 --ARIHRKGWSFCQKLH------ELVLSF----NNLTRL------DEESLAELSSLSVLR 337
Query: 335 MSQNQFQYLPDGFLRKMPSLSHLNL-HQNCLMTLHIREHEPPG--ALTELDLSHNQLSEL 391
+S N ++ +G + + SL L+L H T+ G +L++L L N++
Sbjct: 338 LSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKS- 396
Query: 392 HLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLC 441
+A S L L NL N + V F +N+ L +S + LC
Sbjct: 397 -VAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSF-LC 444
Score = 34.7 bits (78), Expect = 0.30
Identities = 55/190 (28%), Positives = 81/190 (42%), Gaps = 48/190 (25%)
Query: 396 GLASCLGSL----RLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCP-LPAASDRV 450
GLA+ G L R NLS N+L + P F + N+ + +++N+++ P L AAS V
Sbjct: 58 GLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHV 117
Query: 451 GPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWGVLNGSLAPLQDVA 510
F +R S+EG L A SL LDLS N
Sbjct: 118 ----VSLFLQHNKIR--SVEGSQLKAY-------LSLEVLDLSLN--------------- 149
Query: 511 PMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFP--RFGG-SLALETLDLRR 567
+ +RN F +++L+L+GN + T F G S +L TL L +
Sbjct: 150 ---NITEVRN---------TCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSK 197
Query: 568 NSLTALPQKA 577
N +T LP +A
Sbjct: 198 NRITQLPVRA 207
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 95.1 bits (235), Expect = 2e-19
Identities = 109/417 (26%), Positives = 170/417 (40%), Gaps = 53/417 (12%)
Query: 42 DCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAF 101
+C G + +VP+ LP +A L + + L L +L + L RI+ GAF
Sbjct: 44 ECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAF 103
Query: 102 QEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRS 161
+ G LR L L +N L LP + Q L SL S
Sbjct: 104 RNLGSLRYLSLANN-----------KLQVLP-----------------IGLFQGLDSLES 135
Query: 162 VSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCI- 220
+ L+ N ++++ + F L+EL L N++ I GAFD L L LNL N+L I
Sbjct: 136 LLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHIS 195
Query: 221 --VDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQ--LLFFPLLPQYSKLRT 276
V L L+VL + N L + L+ L L NQ LL L L+
Sbjct: 196 PRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQR 255
Query: 277 LLLRDNNMGFYRDLYNTSSPR---------EMVAQFLLVDGNVTNITTVSLWEEFSS--- 324
L L +N++ P+ + L + G + N+ + L++ S
Sbjct: 256 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 315
Query: 325 ----SDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTE 380
S+L L+ L +S+NQ ++ G + L L+LH N L L L
Sbjct: 316 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQN 375
Query: 381 LDLSHNQLSELHLAPG-LASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHN 436
+ L +N+L +L PG + + + L L +NQL +P G+F + + L + N
Sbjct: 376 ISLQNNRLRQL---PGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429
Score = 70.1 bits (170), Expect = 7e-12
Identities = 93/347 (26%), Positives = 138/347 (39%), Gaps = 92/347 (26%)
Query: 326 DLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTL------------------ 367
+L LR+L ++ N+ Q LP G + + SL L L N L+ +
Sbjct: 105 NLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHG 164
Query: 368 -HIREHEPPGA------LTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVP-- 418
H+ E+ P GA LT+L+L N L+ H++P + LG+L++ L N+L +P
Sbjct: 165 NHL-EYIPDGAFDHLVGLTKLNLGKNSLT--HISPRVFQHLGNLQVLRLYENRLTDIPMG 221
Query: 419 ----------------------PGLFANARNITTLDMSHNQISLCP------------LP 444
PGLF N N+ L +S+N IS P L
Sbjct: 222 TFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLT 281
Query: 445 AASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQG-TSLTYLDLSSNW------G 497
+ + S F M +LR L L + +LPD F L L LS N G
Sbjct: 282 LFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPG 341
Query: 498 VLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMA-LD---FSGFGNLRDLDLSGNCLTTFPR 553
NG + LR + LH++ + LD F NL+++ L N L P
Sbjct: 342 AFNG-------------LTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG 388
Query: 554 --FGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDC 598
F L + L+ N L LP + + L + L + L NP+ C
Sbjct: 389 NIFANVNGLMAIQLQNNQLENLP-LGIFDHLGK-LCELRLYDNPWRC 433
Score = 67.4 bits (163), Expect = 4e-11
Identities = 51/166 (30%), Positives = 77/166 (46%), Gaps = 4/166 (2%)
Query: 57 PHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNC 116
P LTL N LK L P P L L L+ H+ + F L+ L+L N
Sbjct: 275 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQ 334
Query: 117 LSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSV 176
+S + A + L LR L L NAL +D+ + + L++L+++SL N + +L ++
Sbjct: 335 ISFI---SPGAFNGLTELRELSLHTNAL-QDLDGNVFRMLANLQNISLQNNRLRQLPGNI 390
Query: 177 FEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVD 222
F + L + LQ N + + G FD L +L L L N C D
Sbjct: 391 FANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSD 436
Score = 58.5 bits (140), Expect = 2e-08
Identities = 68/239 (28%), Positives = 103/239 (43%), Gaps = 51/239 (21%)
Query: 364 LMTLHIRE-HEPP----GALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVP 418
++ HI E +E P AL L + N+LS + PG LGSLR +L++N+L +P
Sbjct: 66 ILNTHITELNESPFLNISALIALRIEKNELSRI--TPGAFRNLGSLRYLSLANNKLQVLP 123
Query: 419 PGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALP 478
GLF ++ +L +S NQ+ ++ P F ++L+ L L G L +P
Sbjct: 124 IGLFQGLDSLESLLLSSNQLL---------QIQP---AHFSQCSNLKELQLHGNHLEYIP 171
Query: 479 DCPFQG-TSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGN 537
D F LT L+L N L ++P + F GN
Sbjct: 172 DGAFDHLVGLTKLNLGKN---------SLTHISPRV------------------FQHLGN 204
Query: 538 LRDLDLSGNCLTTFP--RFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQN 594
L+ L L N LT P F G + L+ L L++N + L + L+ +YLS N
Sbjct: 205 LQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN--NHNLQRLYLSNN 261
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 95.1 bits (235), Expect = 2e-19
Identities = 109/417 (26%), Positives = 170/417 (40%), Gaps = 53/417 (12%)
Query: 42 DCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAF 101
+C G + +VP+ LP +A L + + L L +L + L RI+ GAF
Sbjct: 38 ECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAF 97
Query: 102 QEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRS 161
+ G LR L L +N L LP + Q L SL S
Sbjct: 98 RNLGSLRYLSLANN-----------KLQVLP-----------------IGLFQGLDSLES 129
Query: 162 VSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCI- 220
+ L+ N ++++ + F L+EL L N++ I GAFD L L LNL N+L I
Sbjct: 130 LLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHIS 189
Query: 221 --VDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQ--LLFFPLLPQYSKLRT 276
V L L+VL + N L + L+ L L NQ LL L L+
Sbjct: 190 PRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQR 249
Query: 277 LLLRDNNMGFYRDLYNTSSPR---------EMVAQFLLVDGNVTNITTVSLWEEFSS--- 324
L L +N++ P+ + L + G + N+ + L++ S
Sbjct: 250 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 309
Query: 325 ----SDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTE 380
S+L L+ L +S+NQ ++ G + L L+LH N L L L
Sbjct: 310 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQN 369
Query: 381 LDLSHNQLSELHLAPG-LASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHN 436
+ L +N+L +L PG + + + L L +NQL +P G+F + + L + N
Sbjct: 370 ISLQNNRLRQL---PGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
Score = 70.1 bits (170), Expect = 7e-12
Identities = 93/347 (26%), Positives = 138/347 (39%), Gaps = 92/347 (26%)
Query: 326 DLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTL------------------ 367
+L LR+L ++ N+ Q LP G + + SL L L N L+ +
Sbjct: 99 NLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHG 158
Query: 368 -HIREHEPPGA------LTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVP-- 418
H+ E+ P GA LT+L+L N L+ H++P + LG+L++ L N+L +P
Sbjct: 159 NHL-EYIPDGAFDHLVGLTKLNLGKNSLT--HISPRVFQHLGNLQVLRLYENRLTDIPMG 215
Query: 419 ----------------------PGLFANARNITTLDMSHNQISLCP------------LP 444
PGLF N N+ L +S+N IS P L
Sbjct: 216 TFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLT 275
Query: 445 AASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQG-TSLTYLDLSSNW------G 497
+ + S F M +LR L L + +LPD F L L LS N G
Sbjct: 276 LFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPG 335
Query: 498 VLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMA-LD---FSGFGNLRDLDLSGNCLTTFPR 553
NG + LR + LH++ + LD F NL+++ L N L P
Sbjct: 336 AFNG-------------LTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG 382
Query: 554 --FGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDC 598
F L + L+ N L LP + + L + L + L NP+ C
Sbjct: 383 NIFANVNGLMAIQLQNNQLENLP-LGIFDHLGK-LCELRLYDNPWRC 427
Score = 67.4 bits (163), Expect = 4e-11
Identities = 51/166 (30%), Positives = 77/166 (46%), Gaps = 4/166 (2%)
Query: 57 PHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNC 116
P LTL N LK L P P L L L+ H+ + F L+ L+L N
Sbjct: 269 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQ 328
Query: 117 LSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSV 176
+S + A + L LR L L NAL +D+ + + L++L+++SL N + +L ++
Sbjct: 329 ISFI---SPGAFNGLTELRELSLHTNAL-QDLDGNVFRMLANLQNISLQNNRLRQLPGNI 384
Query: 177 FEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVD 222
F + L + LQ N + + G FD L +L L L N C D
Sbjct: 385 FANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSD 430
Score = 58.5 bits (140), Expect = 2e-08
Identities = 68/239 (28%), Positives = 103/239 (43%), Gaps = 51/239 (21%)
Query: 364 LMTLHIRE-HEPP----GALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVP 418
++ HI E +E P AL L + N+LS + PG LGSLR +L++N+L +P
Sbjct: 60 ILNTHITELNESPFLNISALIALRIEKNELSRI--TPGAFRNLGSLRYLSLANNKLQVLP 117
Query: 419 PGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALP 478
GLF ++ +L +S NQ+ ++ P F ++L+ L L G L +P
Sbjct: 118 IGLFQGLDSLESLLLSSNQLL---------QIQP---AHFSQCSNLKELQLHGNHLEYIP 165
Query: 479 DCPFQG-TSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGN 537
D F LT L+L N L ++P + F GN
Sbjct: 166 DGAFDHLVGLTKLNLGKN---------SLTHISPRV------------------FQHLGN 198
Query: 538 LRDLDLSGNCLTTFP--RFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQN 594
L+ L L N LT P F G + L+ L L++N + L + L+ +YLS N
Sbjct: 199 LQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN--NHNLQRLYLSNN 255
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 94.0 bits (232), Expect = 4e-19
Identities = 122/466 (26%), Positives = 181/466 (38%), Gaps = 68/466 (14%)
Query: 5 PLWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGA-ADCRGQSLASVPSSLPPHARMLT 63
PL L +G SG A C G DC G+ L +VP L + L
Sbjct: 4 PLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALD 63
Query: 64 LDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEE 123
+ N + L + + +P LE L L L I A L+ L L +N L E
Sbjct: 64 ISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSE 123
Query: 124 TAAALHALPGLR---------------------RLDLSGNALTEDMAALMLQNLSSLRSV 162
L AL LR L L N+LTE + L NL +L+++
Sbjct: 124 AIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTE-VPVHPLSNLPTLQAL 182
Query: 163 SLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNL---PC 219
+LA N I + D F L L L L N I + FDGL L L+L +NNL P
Sbjct: 183 TLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ 242
Query: 220 IVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLL 279
+ L L+ L N ++ + AF+ L LRT+ L
Sbjct: 243 AIK-ALPSLKELGFHSN----SISVIPDGAFDGNPL------------------LRTIHL 279
Query: 280 RDNNMGFYRD--LYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSS-SDLADLRFLDMS 336
DN + F + +N S +V I S+ ++F + + L L ++
Sbjct: 280 YDNPLSFVGNSAFHNLSDLHSLV------------IRGASMVQQFPNLTGTVHLESLTLT 327
Query: 337 QNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPG 396
+ +P+ ++ L L+L N + L AL E+ L NQ+ + + G
Sbjct: 328 GTKISSIPNNLCQEQKMLRTLDLSYNNIRDL--PSFNGCHALEEISLQRNQIYQ--IKEG 383
Query: 397 LASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCP 442
L SLR+ +LS N + + FA IT LD+S N+++ P
Sbjct: 384 TFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFP 429
Score = 74.3 bits (181), Expect = 3e-13
Identities = 108/430 (25%), Positives = 168/430 (39%), Gaps = 90/430 (20%)
Query: 175 SVFEGLERLRE-LDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNV 233
+V EGL + LD+ N I ++ AF L L LA N+L I L+ L+
Sbjct: 50 AVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLK---- 105
Query: 234 SYNVLEWFLATGGEAAFELETLDLSHNQLLFFP--LLPQYSKLRTLLLRDNNMGFYRDLY 291
EL+ L L +NQL P + S L++L L N++
Sbjct: 106 -----------------ELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHI------- 141
Query: 292 NTSSPRE------MVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPD 345
TS P + + L D ++T + L S+L L+ L ++ N+ +PD
Sbjct: 142 -TSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPL------SNLPTLQALTLALNKISSIPD 194
Query: 346 GFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLR 405
+ SL L+LH N + +L + L LDL++N L E P L SL+
Sbjct: 195 FAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF---PQAIKALPSLK 251
Query: 406 LFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLR 465
SN + +P G F + T+ + N +S A F N++ L
Sbjct: 252 ELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSA------------FHNLSDLH 299
Query: 466 SLSLEGCGL-GALPDCPFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLH 524
SL + G + P+ T +L+ + G ++ S+ N
Sbjct: 300 SLVIRGASMVQQFPNL----TGTVHLESLTLTGT---------------KISSIPNNLCQ 340
Query: 525 SSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQLSR 584
M LR LDLS N + P F G ALE + L+RN + + + +S
Sbjct: 341 EQKM---------LRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLIS- 390
Query: 585 GLRTIYLSQN 594
LR + LS+N
Sbjct: 391 -LRILDLSRN 399
Score = 67.0 bits (162), Expect = 6e-11
Identities = 57/217 (26%), Positives = 92/217 (42%), Gaps = 25/217 (11%)
Query: 42 DCRGQSLASVPSSLP--PHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRG 99
D +L P ++ P + L +N + + + + PLL ++ L+ L +
Sbjct: 231 DLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNS 290
Query: 100 AFQEQGHLRSLVLGDNCLSENYEETAAALH------------ALPG--------LRRLDL 139
AF L SLV+ + + + +H ++P LR LDL
Sbjct: 291 AFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDL 350
Query: 140 SGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGG 199
S N + D+ + +L +SL N I ++ + F+GL LR LDL RN I EI
Sbjct: 351 SYNNI-RDLPSF--NGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSR 407
Query: 200 AFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYN 236
AF L + +L+++FN L GL L L + N
Sbjct: 408 AFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGN 444
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 91.7 bits (226), Expect = 2e-18
Identities = 146/543 (26%), Positives = 226/543 (41%), Gaps = 73/543 (13%)
Query: 39 GAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISR 98
G DC G L P LP H L+L N L+ ++ L LE+L+L + L SR
Sbjct: 126 GVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRL--TSR 183
Query: 99 G----AFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQ 154
G AF+ +L L L +N L T A L +D + N LT+ + L
Sbjct: 184 GLPEKAFEHLTNLNYLYLANNKL------TLAPRFLPNALISVDFAANYLTK-IYGLTFG 236
Query: 155 NLSSLRSVSLAGNTI--MRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNL 212
+LRSV L N + L D++F G + L L N++ + L +L N
Sbjct: 237 QKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNN 296
Query: 213 AFNNLPCIVDFGLTRLRVLNVSYNVLE---------WFLATGGEAAFELETLDLSHNQLL 263
+P L+ LR L + N L W L++ LE LDLS N L
Sbjct: 297 KLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSS-------LEYLDLSSNNLS 349
Query: 264 FFPL-LPQYSKLRTLLLRDNNMGFYRDL-YNTSSPREMVAQFLLVDGNVTNITTVSLWEE 321
P LP R+L+L R + N +P + ++LL+ N +
Sbjct: 350 RVPAGLP-----RSLVLLHLEKNAIRSVDANVLTPIRSL-EYLLLHSNQLREQGI---HP 400
Query: 322 FSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTEL 381
+ L L + + N + +P G R++ +L L+ N + + + L EL
Sbjct: 401 LAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILH---NQITGIGREDFATTYFLEEL 457
Query: 382 DLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQIS-- 439
+LS+N+++ + L LR +LS N+L +PPGL RN+ L + N+++
Sbjct: 458 NLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGL---PRNVHVLKVKRNELAAL 514
Query: 440 ----------LCPLPAASDR-----VGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQG 484
L L S+R +GP + VD +A L+ L + G L +P+
Sbjct: 515 ARGALVGMAQLRELYLTSNRLRSRALGPRAWVD---LAHLQLLDIAGNQLTEIPE--GLP 569
Query: 485 TSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLR-NMGLHSSFMALDFSGFGNLRDLDL 543
SL YL L +N ++ A D P L+ + LR N S + F +L+ LD+
Sbjct: 570 ESLEYLYLQNN--KISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDI 627
Query: 544 SGN 546
GN
Sbjct: 628 EGN 630
Score = 63.5 bits (153), Expect = 6e-10
Identities = 139/549 (25%), Positives = 209/549 (38%), Gaps = 130/549 (23%)
Query: 106 HLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTE-DMAALMLQNLSSLRSVSL 164
H L L +N L + Y E + LH L L+L N LT + ++L++L + L
Sbjct: 145 HTNHLSLQNNQLEKIYPEELSRLHRL---ETLNLQNNRLTSRGLPEKAFEHLTNLNYLYL 201
Query: 165 AGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFG 224
A N + + L +D NY+ +I G F LR + L N L D G
Sbjct: 202 ANNKLTLAPRFLPNALI---SVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKL---ADAG 255
Query: 225 LTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFP--LLPQYSKLRTLLLRDN 282
L + N S NV E L LS N L P L P KL L++N
Sbjct: 256 LPD-NMFNGSSNV---------------EVLILSSNFLRHVPKHLPPALYKLH---LKNN 296
Query: 283 NM-----GFYRDLYNTSSPREMVAQF-LLVDGNVTNITTVSLWEEFSSSDLADLRFLDMS 336
+ G + +L SS RE+ Q L D + N T W+ L+ L +LD+S
Sbjct: 297 KLEKIPPGAFSEL---SSLRELYLQNNYLTDEGLDNET---FWK------LSSLEYLDLS 344
Query: 337 QNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPG 396
N +P G R SL L+L +N + ++ P +L L L NQL E
Sbjct: 345 SNNLSRVPAGLPR---SLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQ----- 396
Query: 397 LASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCV 456
G+ P F + + T+ + +N + P G P
Sbjct: 397 -------------------GIHPLAFQGLKRLHTVHLYNNALERVPS-------GLP--- 427
Query: 457 DFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVL 516
R + +L L + G+G D ++ + + +L+ + +P +
Sbjct: 428 --RRVRTLMILHNQITGIGRE-------------DFATTYFLEELNLSYNRITSPQVHRD 472
Query: 517 SLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQK 576
+ R + L LR LDLSGN L T P G + L ++RN L AL +
Sbjct: 473 AFRKLRL--------------LRSLDLSGNRLHTLPP-GLPRNVHVLKVKRNELAALARG 517
Query: 577 AVSEQLSRGLRTIYLSQNPY--DCCGVDGWGALQHGQTVADWAMVTCNLSSKIIRVTELP 634
A+ LR +YL+ N G W L H Q L ++TE+P
Sbjct: 518 ALVGMAQ--LRELYLTSNRLRSRALGPRAWVDLAHLQL----------LDIAGNQLTEIP 565
Query: 635 GGVPRDCKW 643
G+P ++
Sbjct: 566 EGLPESLEY 574
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 90.5 bits (223), Expect = 5e-18
Identities = 147/642 (22%), Positives = 248/642 (38%), Gaps = 99/642 (15%)
Query: 18 GWRNRSGTATAAS---QGVCKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWN 74
G R T T +S +C G DCRG+ L ++P++LP + L+ N +K++
Sbjct: 267 GEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPP 326
Query: 75 HSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGL 134
+ PY L + L + + I+ AFQ L L
Sbjct: 327 GAFSPYRKLRRIDLSNNQIAEIAPDAFQ---------------------------GLRSL 359
Query: 135 RRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIF 194
L L GN +T D+ + L +L+ + L N I + F+ L+ L L L N I
Sbjct: 360 NSLVLYGNKIT-DLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQ 418
Query: 195 EIEGGAFDGLAELRHLNLAFN------NLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEA 248
+ G F L ++ L+LA N NL + DF T + + LA
Sbjct: 419 SLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIG 478
Query: 249 AFELETLDLSHNQLLFFPLLPQY---SKLRTLLLRDNNMGFYRDLYNTSSPR-------- 297
+ + S + F P Y S+ + ++ + ++ SS +
Sbjct: 479 QIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERI 538
Query: 298 -EMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSH 356
+ A+ L + ++ + ++++ L L+ +++S N+ + DG S+S
Sbjct: 539 PQSTAELRLNNNEISILEATGMFKK-----LTHLKKINLSNNKVSEIEDGAFEGAASVSE 593
Query: 357 LNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLG 416
L+L N L ++ L L L +N++S +H + L ++RL +L NQ+
Sbjct: 594 LHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIH--NDSFTGLRNVRLLSLYDNQITT 651
Query: 417 VPPGLFANARNITTLDMSHNQISL-CPLPAASDRV-------GPPSC--VDFRNMASLRS 466
V PG F ++++TL++ N + C L + G P C DF L+
Sbjct: 652 VSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQD 711
Query: 467 LSL---------EGCGLGALPDCPFQGTSLTYLDLSSNWGV---------------LNG- 501
++ E G P CP + L + SN + L+G
Sbjct: 712 VAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGN 771
Query: 502 --SLAPLQ-DVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFP--RFGG 556
+L P Q LQ++ L N + SS F+ L L LS N L P F G
Sbjct: 772 QFTLVPGQLSTFKYLQLVDLSNNKI-SSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQG 830
Query: 557 SLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDC 598
+L L L N ++ L + ++ S L + + NP C
Sbjct: 831 LRSLRLLSLHGNDISTLQEGIFADVTS--LSHLAIGANPLYC 870
Score = 84.3 bits (207), Expect = 3e-16
Identities = 152/661 (22%), Positives = 243/661 (36%), Gaps = 97/661 (14%)
Query: 6 LWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHARMLTLD 65
LWL L WR +A +C G DC G L ++P ++P + L L+
Sbjct: 18 LWLLLW----AAAWR----LGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELN 69
Query: 66 ANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETA 125
N + + + L L L + + RGAF + L L L N
Sbjct: 70 GNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRN---------- 119
Query: 126 AALHALP--------GLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVF 177
LH LP L RLDLS NA+ + + + + L+++ L N I +++ F
Sbjct: 120 -QLHMLPELLFQNNQALSRLDLSENAI-QAIPRKAFRGATDLKNLQLDKNQISCIEEGAF 177
Query: 178 EGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDF-------------- 223
L L L L N I I +F+ + +LR L N+L C
Sbjct: 178 RALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIG 237
Query: 224 ------GLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTL 277
G LR LNV+ F +G A + T LS +
Sbjct: 238 LFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSS------------GSCPAM 285
Query: 278 LLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQ 337
N + R T+ P + + + I ++ + S LR +D+S
Sbjct: 286 CTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSI---PPGAFSPYRKLRRIDLSN 342
Query: 338 NQF-QYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPG 396
NQ + PD F + + SL+ L L+ N + L L L L+ N+++ + P
Sbjct: 343 NQIAEIAPDAF-QGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKIN--CIRPD 399
Query: 397 LASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQ-ISLCPLPAASD--RVGP- 452
L +L L +L N++ + G F + R I TL ++ N I C L +D R P
Sbjct: 400 AFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPI 459
Query: 453 ----PSCVDFRNMASLR--SLSLEGCGLGALPDCPFQGTSLTYLDLSSNWGVL------- 499
C R +A+ R + + A GT L+ N V+
Sbjct: 460 ETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRC 519
Query: 500 --------NGSLAPLQDVAPMLQV-LSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTT 550
+ L + + P L L N + F +L+ ++LS N ++
Sbjct: 520 EANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSE 579
Query: 551 FP--RFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGALQ 608
F G+ ++ L L N L ++ + + L GLRT+ L N C D + L+
Sbjct: 580 IEDGAFEGAASVSELHLTANQLESI-RSGMFRGLD-GLRTLMLRNNRISCIHNDSFTGLR 637
Query: 609 H 609
+
Sbjct: 638 N 638
Score = 44.7 bits (104), Expect = 3e-04
Identities = 65/282 (23%), Positives = 109/282 (38%), Gaps = 31/282 (10%)
Query: 375 PGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMS 434
P L+L+ N ++ +H L LR+ L NQ+ V G F + + + L ++
Sbjct: 60 PRNTERLELNGNNITRIHKNDFAG--LKQLRVLQLMENQIGAVERGAFDDMKELERLRLN 117
Query: 435 HNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQG-TSLTYLDLS 493
NQ+ + P + F+N +L L L + A+P F+G T L L L
Sbjct: 118 RNQLHMLPE------------LLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLD 165
Query: 494 SNW--GVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTF 551
N + G+ L+ L+VL+L N + ++ F+ LR L N L
Sbjct: 166 KNQISCIEEGAFRALRG----LEVLTLNNNNI-TTIPVSSFNHMPKLRTFRLHSNHLFC- 219
Query: 552 PRFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGALQHGQ 611
LA + LR+ L + RGL + ++ + C G G +
Sbjct: 220 ---DCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCT 276
Query: 612 TVADWAMVTCNLSSKII-----RVTELPGGVPRDCKWERLDL 648
+ C S+ I+ +T +P +P RL+L
Sbjct: 277 LSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLEL 318
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 88.2 bits (217), Expect = 2e-17
Identities = 159/652 (24%), Positives = 265/652 (40%), Gaps = 84/652 (12%)
Query: 24 GTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLL 83
G A+S C + ADC L VP LP + +L L N L+ L + Y L
Sbjct: 18 GMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQL 77
Query: 84 ESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAA------ALHAL------ 131
SL + + ++ Q+ L+ L L N LS+ ++T A LH +
Sbjct: 78 TSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQK 137
Query: 132 ---------PGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFE--GL 180
L LDLS N L+ +Q L +L+ + L+ N I L +
Sbjct: 138 IKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQ-LENLQELLLSNNKIQALKSEELDIFAN 196
Query: 181 ERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNL--------PCIVDFGLTRLRVLN 232
L++L+L N I E G F + L L NN+ ++ T +R L+
Sbjct: 197 SSLKKLELSSNQIKEFSPGCFHAIGRL--FGLFLNNVQLGPSLTEKLCLELANTSIRNLS 254
Query: 233 VSYNVLEWFLATG--GEAAFELETLDLSHNQLLF-----FPLLPQYSKLRTLLLRDNNMG 285
+S + L T G L LDLS+N L F LPQ L L NN+
Sbjct: 255 LSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQ---LEYFFLEYNNIQ 311
Query: 286 --FYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYL 343
F L+ + R + + ++ ++ ++ ++FS L L L+M N +
Sbjct: 312 HLFSHSLHGLFNVRYLNLKRSFTKQSI-SLASLPKIDDFSFQWLKCLEHLNMEDNDIPGI 370
Query: 344 PDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTE-----LDLSHNQLSELHLAPGLA 398
+ +L +L+L N +L +E +L L+L+ N++S++
Sbjct: 371 KSNMFTGLINLKYLSL-SNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIE--SDAF 427
Query: 399 SCLGSLRLFNLSSNQLLGVPPGL-FANARNITTLDMSHNQ--------ISLCP------L 443
S LG L + +L N++ G + NI + +S+N+ +L P L
Sbjct: 428 SWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLML 487
Query: 444 PAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQG-TSLTYLDLSSN-----WG 497
+ + S F+ + +L L L + + D +G L LDL N W
Sbjct: 488 RRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWK 547
Query: 498 VLN--GSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPR-- 553
N G + L+ ++ L +L+L + G + + F L+ +DL N L T P
Sbjct: 548 HANPGGPIYFLKGLS-HLHILNLESNGFDEIPVEV-FKDLFELKIIDLGLNNLNTLPASV 605
Query: 554 FGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDC-CGVDGW 604
F ++L++L+L++N +T++ +K V R L + + NP+DC C W
Sbjct: 606 FNNQVSLKSLNLQKNLITSV-EKKVFGPAFRNLTELDMRFNPFDCTCESIAW 656
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 88.2 bits (217), Expect = 2e-17
Identities = 79/292 (27%), Positives = 125/292 (42%), Gaps = 15/292 (5%)
Query: 156 LSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFN 215
L L + + G++ + L ++F L L +L L N + + G F LA L L+L N
Sbjct: 96 LPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGN 155
Query: 216 NLPCI---VDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFP--LLPQ 270
L + + LT L+ LN++ N+L L+TL LS+N L P + +
Sbjct: 156 QLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGK 215
Query: 271 YSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADL 330
L+ L L NN+ + P ++ +Q ++ ++ + L +L
Sbjct: 216 LGSLQELFLDSNNI--------SELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNL 267
Query: 331 RFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSE 390
FL + N + LP G P L L+L N L T+ L L LS+N ++
Sbjct: 268 TFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAIT- 326
Query: 391 LHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCP 442
HL G+ L L L SN L + P LF N + L +S NQ++ P
Sbjct: 327 -HLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLP 377
Score = 88.2 bits (217), Expect = 2e-17
Identities = 96/316 (30%), Positives = 130/316 (41%), Gaps = 61/316 (19%)
Query: 62 LTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENY 121
LTL+ N L+ L Q LESL L L+ + R FQ HL++L L N L++
Sbjct: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185
Query: 122 EETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLE 181
EE H L L+ L LS NAL+ + + L SL+ + L N I L VF L
Sbjct: 186 EE---LFHPLTSLQTLKLSNNALS-GLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLF 241
Query: 182 RLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNL-----------PCIVDFGLTRLRV 230
L L LQRN I + F L L L+L +N L PC+V LT
Sbjct: 242 CLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLT---- 297
Query: 231 LNVSYNVLEWFLATGGEAAF----ELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGF 286
+N LE T E F L +L LS+N + P G
Sbjct: 298 ----HNQLE----TVAEGTFAHLSNLRSLMLSYNAITHLP-----------------AGI 332
Query: 287 YRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDG 346
+RDL E + + L N+T + +L+ L L +S+NQ LP+G
Sbjct: 333 FRDL-------EELVKLYLGSNNLTALHPALF------QNLSKLELLSLSKNQLTTLPEG 379
Query: 347 FLRKMPSLSHLNLHQN 362
+L +L LH N
Sbjct: 380 IFDTNYNLFNLALHGN 395
Score = 77.8 bits (190), Expect = 3e-14
Identities = 94/353 (26%), Positives = 144/353 (40%), Gaps = 15/353 (4%)
Query: 43 CRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQ 102
C + LA+VP +PP+ + + TL + P L + + L + AF
Sbjct: 35 CSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFG 94
Query: 103 EQGHLRSL-VLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRS 161
L L V G + L+ + L L +L L+ N L E + + Q+L++L S
Sbjct: 95 GLPRLEDLEVTGSSFLNLSTN----IFSNLTSLGKLTLNFNML-EALPEGLFQHLAALES 149
Query: 162 VSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNL---AFNNLP 218
+ L GN + L +F+ L L+ L+L +N + ++ F L L+ L L A + LP
Sbjct: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP 209
Query: 219 CIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLL 278
V L L+ L + N + F LE L L N + PL ++ L L
Sbjct: 210 QGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPL-SIFASLGNLT 268
Query: 279 LRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQN 338
R L P + A + G + E + + L++LR L +S N
Sbjct: 269 FLSLQWNMLRVL-----PAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYN 323
Query: 339 QFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSEL 391
+LP G R + L L L N L LH + L L LS NQL+ L
Sbjct: 324 AITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTL 376
Score = 69.7 bits (169), Expect = 9e-12
Identities = 92/368 (25%), Positives = 140/368 (38%), Gaps = 52/368 (14%)
Query: 146 EDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLA 205
E++A + L +++ + L+ F L ++ + + AF GL
Sbjct: 38 EELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLP 97
Query: 206 ELRHLNL---AFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQL 262
L L + +F NL + LT L L +++N+LE + LE+L L NQL
Sbjct: 98 RLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQL 157
Query: 263 LFFP--LLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWE 320
P L + L+TL L N + P E+
Sbjct: 158 QALPRRLFQPLTHLKTLNLAQNLLA--------QLPEELF-------------------- 189
Query: 321 EFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTE 380
L L+ L +S N LP G K+ SL L L N + L + L
Sbjct: 190 ----HPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
Query: 381 LDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQI-- 438
L L N ++ HL + + LG+L +L N L +P GLFA+ + L ++HNQ+
Sbjct: 246 LWLQRNAIT--HLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLET 303
Query: 439 ----------SLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTS-L 487
+L L + + + FR++ L L L L AL FQ S L
Sbjct: 304 VAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKL 363
Query: 488 TYLDLSSN 495
L LS N
Sbjct: 364 ELLSLSKN 371
Score = 33.9 bits (76), Expect = 0.52
Identities = 29/75 (38%), Positives = 39/75 (52%), Gaps = 7/75 (9%)
Query: 525 SSFMALDFSGFGNLRDLD---LSGNCLTTFPR--FGGSLALETLDLRRNSLTALPQKAVS 579
SSF+ L + F NL L L+ N L P F ALE+L L+ N L ALP++
Sbjct: 107 SSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLF- 165
Query: 580 EQLSRGLRTIYLSQN 594
Q L+T+ L+QN
Sbjct: 166 -QPLTHLKTLNLAQN 179
Score = 32.3 bits (72), Expect = 1.5
Identities = 38/140 (27%), Positives = 59/140 (42%), Gaps = 25/140 (17%)
Query: 473 GLGALPDCPFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALD- 531
GL L D G+S +L+LS+N + +L L + +L GL AL+
Sbjct: 95 GLPRLEDLEVTGSS--FLNLSTN---IFSNLTSLGKLTLNFNMLEALPEGLFQHLAALES 149
Query: 532 ---------------FSGFGNLRDLDLSGNCLTTFPR--FGGSLALETLDLRRNSLTALP 574
F +L+ L+L+ N L P F +L+TL L N+L+ LP
Sbjct: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP 209
Query: 575 QKAVSEQLSRGLRTIYLSQN 594
Q + S L+ ++L N
Sbjct: 210 QGVFGKLGS--LQELFLDSN 227
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 87.8 bits (216), Expect = 3e-17
Identities = 127/437 (29%), Positives = 166/437 (37%), Gaps = 96/437 (21%)
Query: 162 VSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFE--IEGGAFDGLAELRHLNLAFNNLPC 219
+SL N + L + L LR L+L N I + AF+ L +L+HL +A N L
Sbjct: 77 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 136
Query: 220 IVDFGLTRLRVLNVSYN-VLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLL 278
F LRV +++ N V+E F T GE L ++ L +NQL
Sbjct: 137 APQFLPRSLRVADLAANQVMEIFPLTFGEKP-ALRSVYLHNNQL---------------- 179
Query: 279 LRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQN 338
+N G D + S I T+SL S N
Sbjct: 180 ---SNAGLPPDAFRGSEA----------------IATLSL-----------------SNN 203
Query: 339 QFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLA 398
Q YLP PSL L+L N + + L EL L HNQL++ L
Sbjct: 204 QLSYLPPSL---PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTF 260
Query: 399 SCLGSLRLFNLSSNQLLGVPPGL---------------------FANARNITTLDMSHNQ 437
S L SL +LS NQL VP GL AR + L + HNQ
Sbjct: 261 SKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQ 320
Query: 438 ISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWG 497
+ LPA + R + L +L L G GL +P P L L L N
Sbjct: 321 LGSSGLPAGA----------LRPLRGLHTLHLYGNGLDRVP--PALPRRLRALVLPHNHV 368
Query: 498 VLNGSLAPLQDVAPMLQVLSLRNMGLHSSFM-ALDFSGFGNLRDLDLSGNCLTTFPRFGG 556
G+ + P L L+L L S+ + F LR LDL+GN LT P G
Sbjct: 369 AALGARDLV--ATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLP-MGL 425
Query: 557 SLALETLDLRRNSLTAL 573
L TL L+RN L L
Sbjct: 426 PTGLRTLQLQRNQLRML 442
Score = 78.6 bits (192), Expect = 2e-14
Identities = 118/425 (27%), Positives = 170/425 (40%), Gaps = 46/425 (10%)
Query: 42 DCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHL--ERISRG 99
DC G L P ++ A+ L+L N L+ L + L L +L+LH+ + E +
Sbjct: 57 DCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDE 116
Query: 100 AFQEQGHLRSLVLGDNCLSENYEETAAALHALP-GLRRLDLSGNALTEDMAALMLQNLSS 158
AF+ L+ L + N LS A LP LR DL+ N + E + L +
Sbjct: 117 AFESLTQLQHLCVAHNKLS-------VAPQFLPRSLRVADLAANQVME-IFPLTFGEKPA 168
Query: 159 LRSVSLAGNTIMR--LDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNN 216
LRSV L N + L F G E + L L N + + L L N +
Sbjct: 169 LRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISK 228
Query: 217 LPCIVDFGLTRLRVLNVSYNVL--EWFLATGGEAAFELETLDLSHNQLLFFPL-LPQYSK 273
+P T+LR L + +N L AT LE LDLSHNQL P LP
Sbjct: 229 VPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLP---- 284
Query: 274 LRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGN--------------VTNITTVSLW 319
RTL + R + ++LL+ N + + T+ L+
Sbjct: 285 -RTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLY 343
Query: 320 ----EEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMT--LHIREHE 373
+ + LR L + N L L P L+ LNL N L + +H R
Sbjct: 344 GNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFR 403
Query: 374 PPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDM 433
AL LDL+ NQL+ L + GL + LR L NQL + P A + L +
Sbjct: 404 RLRALRSLDLAGNQLTRLPM--GLPT---GLRTLQLQRNQLRMLEPEPLAGLDQLRELSL 458
Query: 434 SHNQI 438
+HN++
Sbjct: 459 AHNRL 463
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 87.8 bits (216), Expect = 3e-17
Identities = 127/437 (29%), Positives = 166/437 (37%), Gaps = 96/437 (21%)
Query: 162 VSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFE--IEGGAFDGLAELRHLNLAFNNLPC 219
+SL N + L + L LR L+L N I + AF+ L +L+HL +A N L
Sbjct: 79 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 138
Query: 220 IVDFGLTRLRVLNVSYN-VLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLL 278
F LRV +++ N V+E F T GE L ++ L +NQL
Sbjct: 139 APQFLPRSLRVADLAANQVMEIFPLTFGEKP-ALRSVYLHNNQL---------------- 181
Query: 279 LRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQN 338
+N G D + S I T+SL S N
Sbjct: 182 ---SNAGLPPDAFRGSEA----------------IATLSL-----------------SNN 205
Query: 339 QFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLA 398
Q YLP PSL L+L N + + L EL L HNQL++ L
Sbjct: 206 QLSYLPPSL---PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTF 262
Query: 399 SCLGSLRLFNLSSNQLLGVPPGL---------------------FANARNITTLDMSHNQ 437
S L SL +LS NQL VP GL AR + L + HNQ
Sbjct: 263 SKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQ 322
Query: 438 ISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWG 497
+ LPA + R + L +L L G GL +P P L L L N
Sbjct: 323 LGSSGLPAGA----------LRPLRGLHTLHLYGNGLDRVP--PALPRRLRALVLPHNHV 370
Query: 498 VLNGSLAPLQDVAPMLQVLSLRNMGLHSSFM-ALDFSGFGNLRDLDLSGNCLTTFPRFGG 556
G+ + P L L+L L S+ + F LR LDL+GN LT P G
Sbjct: 371 AALGARDLV--ATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLP-MGL 427
Query: 557 SLALETLDLRRNSLTAL 573
L TL L+RN L L
Sbjct: 428 PTGLRTLQLQRNQLRML 444
Score = 78.6 bits (192), Expect = 2e-14
Identities = 118/425 (27%), Positives = 170/425 (40%), Gaps = 46/425 (10%)
Query: 42 DCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHL--ERISRG 99
DC G L P ++ A+ L+L N L+ L + L L +L+LH+ + E +
Sbjct: 59 DCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDE 118
Query: 100 AFQEQGHLRSLVLGDNCLSENYEETAAALHALP-GLRRLDLSGNALTEDMAALMLQNLSS 158
AF+ L+ L + N LS A LP LR DL+ N + E + L +
Sbjct: 119 AFESLTQLQHLCVAHNKLS-------VAPQFLPRSLRVADLAANQVME-IFPLTFGEKPA 170
Query: 159 LRSVSLAGNTIMR--LDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNN 216
LRSV L N + L F G E + L L N + + L L N +
Sbjct: 171 LRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISK 230
Query: 217 LPCIVDFGLTRLRVLNVSYNVL--EWFLATGGEAAFELETLDLSHNQLLFFPL-LPQYSK 273
+P T+LR L + +N L AT LE LDLSHNQL P LP
Sbjct: 231 VPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLP---- 286
Query: 274 LRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGN--------------VTNITTVSLW 319
RTL + R + ++LL+ N + + T+ L+
Sbjct: 287 -RTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLY 345
Query: 320 ----EEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMT--LHIREHE 373
+ + LR L + N L L P L+ LNL N L + +H R
Sbjct: 346 GNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFR 405
Query: 374 PPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDM 433
AL LDL+ NQL+ L + GL + LR L NQL + P A + L +
Sbjct: 406 RLRALRSLDLAGNQLTRLPM--GLPT---GLRTLQLQRNQLRMLEPEPLAGLDQLRELSL 460
Query: 434 SHNQI 438
+HN++
Sbjct: 461 AHNRL 465
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 87.4 bits (215), Expect = 4e-17
Identities = 142/631 (22%), Positives = 244/631 (38%), Gaps = 119/631 (18%)
Query: 34 CKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHL 93
C DCRG+ L +P++LP + L+ N +K
Sbjct: 284 CTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKA---------------------- 321
Query: 94 ERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALML 153
I GAF + L+ + + N +S+ + A L L L L GN +TE +A +
Sbjct: 322 --IPAGAFTQYKKLKRIDISKNQISDIAPD---AFQGLKSLTSLVLYGNKITE-IAKGLF 375
Query: 154 QNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLA 213
L SL+ + L N I L + F+ L+ L L L N + I G F L ++ L+LA
Sbjct: 376 DGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLA 435
Query: 214 FNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSK 273
N C L+W + E S + L + S+
Sbjct: 436 QNPFVCDCH---------------LKWLADYLQDNPIETSGARCSSPRRL---ANKRISQ 477
Query: 274 LRTLLLRDNNMGFYRDLYNTSSPREMVA-QFLLVDGNVTNITTVSLWE--EFSSSDLADL 330
+++ R + YR +++ ++V + +G + + + L + DL
Sbjct: 478 IKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDL 537
Query: 331 RFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSE 390
R D + + G +K+P+L +NL N + + + ++ EL L+ NQL
Sbjct: 538 RLNDNEVSVLE--ATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLET 595
Query: 391 LH--------------LAPGLASC--------LGSLRLFNLSSNQLLGVPPGLFANARNI 428
+H L L C L S+RL +L N++ + PG F ++
Sbjct: 596 VHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSL 655
Query: 429 TTLDMSHNQISL-CPLPAASDRV-------GPPSC--------VDFRNMASLRSLSLEG- 471
+T+++ N + C L + G P C + +++A ++ + +G
Sbjct: 656 STINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVA-IQDFTCDGN 714
Query: 472 ----CGLGALPDCPFQGTSLTYLDLSSNWGV---------------LNGS-LAPLQDVAP 511
C L P CP Q T + + SN G+ L G+ L +
Sbjct: 715 EESSCQLS--PRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELS 772
Query: 512 MLQVLSLRNMGLHSSFMALD--FSGFGNLRDLDLSGNCLTTFP--RFGGSLALETLDLRR 567
L+ L+L ++ +S M + FS +L L LS N L P F G +L L L
Sbjct: 773 ALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHG 832
Query: 568 NSLTALPQKAVSEQLSRGLRTIYLSQNPYDC 598
N ++++P+ + ++ S L + L NP C
Sbjct: 833 NDISSVPEGSFNDLTS--LSHLALGTNPLHC 861
Score = 76.6 bits (187), Expect = 7e-14
Identities = 58/197 (29%), Positives = 85/197 (43%), Gaps = 4/197 (2%)
Query: 23 SGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPL 82
SG A C + DC G L +VP +P +A L LD N + +
Sbjct: 27 SGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKN 86
Query: 83 LESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGN 142
L L L + I RGAFQ+ L L L N L E + P L RLDLS N
Sbjct: 87 LRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPE---LLFQSTPKLTRLDLSEN 143
Query: 143 ALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFD 202
+ + + + ++ ++++ L N I ++D F L L L L N I I +F+
Sbjct: 144 QI-QGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFN 202
Query: 203 GLAELRHLNLAFNNLPC 219
+ ++R L L N+L C
Sbjct: 203 HMPKIRTLRLHSNHLYC 219
Score = 74.3 bits (181), Expect = 3e-13
Identities = 95/396 (23%), Positives = 158/396 (39%), Gaps = 62/396 (15%)
Query: 34 CKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHL 93
C+ G DC Q L +PS LP + L L+ N + L
Sbjct: 509 CRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVL--------------------- 547
Query: 94 ERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALML 153
+ G F++ +LR + L +N + E E A ++ L L+GN L E + +
Sbjct: 548 --EATGIFKKLPNLRKINLSNNKIKEVRE---GAFDGAASVQELMLTGNQL-ETVHGRVF 601
Query: 154 QNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLA 213
+ LS L+++ L N I + + F GL +R L L N I I GAF L L +NL
Sbjct: 602 RGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLL 661
Query: 214 FNNLPCIVDFG-----LTRLRVLNVSYNVLEWFLATG---GEAAFELETLD-LSHNQLLF 264
N C L + R+++ + + F + A + T D +
Sbjct: 662 SNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQL 721
Query: 265 FPLLPQYSKLRTLLLRDNNMG---------------FYRDLYNTSSPREMVAQFLLVDGN 309
P P+ ++R +N G + + T+ PRE+ A L +
Sbjct: 722 SPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLID 781
Query: 310 VTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHI 369
++N ++S+ ++ S+++ L L +S N+ + +P + SL L LH N + ++
Sbjct: 782 LSN-NSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSV-- 838
Query: 370 REHEPPGALTELDLSHNQLSELHLAPGLASCLGSLR 405
P G+ +L LS L L C SLR
Sbjct: 839 ----PEGSFNDL----TSLSHLALGTNPLHCDCSLR 866
Score = 45.8 bits (107), Expect = 1e-04
Identities = 36/132 (27%), Positives = 60/132 (45%), Gaps = 10/132 (7%)
Query: 309 NVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLH 368
N+T IT + + L +LR L + NQ + G + + L L L++N L L
Sbjct: 72 NITRITKMDF------AGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLP 125
Query: 369 IREHEPPGALTELDLSHNQLSELHLAPGLA-SCLGSLRLFNLSSNQLLGVPPGLFANARN 427
+ LT LDLS NQ+ + P A + ++ L +N + + G F R+
Sbjct: 126 ELLFQSTPKLTRLDLSENQIQGI---PRKAFRGITDVKNLQLDNNHISCIEDGAFRALRD 182
Query: 428 ITTLDMSHNQIS 439
+ L +++N IS
Sbjct: 183 LEILTLNNNNIS 194
Score = 43.1 bits (100), Expect = 9e-04
Identities = 86/365 (23%), Positives = 143/365 (39%), Gaps = 73/365 (20%)
Query: 175 SVFEGLERLRE-LDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFG----LTRLR 229
+V G+ R E LDL RN I I F GL LR L+L N + +++ G L +L
Sbjct: 54 AVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQV-SVIERGAFQDLKQLE 112
Query: 230 VLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFP--LLPQYSKLRTLLLRDNNMGFY 287
L ++ N L+ ++ +L LDLS NQ+ P + ++ L L +N++
Sbjct: 113 RLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCI 172
Query: 288 RD-LYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQN------QF 340
D + E++ L + N++ I S + + +R L + N
Sbjct: 173 EDGAFRALRDLEILT---LNNNNISRILVTSF------NHMPKIRTLRLHSNHLYCDCHL 223
Query: 341 QYLPDGFLRKMPSLSHLNLHQNCLMTLHIR-----------------EHEPPGALTELDL 383
+L D +LR+ ++ L C+ +H+R EPP
Sbjct: 224 AWLSD-WLRQRRTVGQFTL---CMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNAN--- 276
Query: 384 SHNQLSELHLAPGLASCLG------------SLRLFNLSSNQLLGVPPGLFANARNITTL 431
S + S + + C G + L N + +P G F + + +
Sbjct: 277 SISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRI 336
Query: 432 DMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQG-TSLTYL 490
D+S NQIS + P + F+ + SL SL L G + + F G SL L
Sbjct: 337 DISKNQIS---------DIAPDA---FQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLL 384
Query: 491 DLSSN 495
L++N
Sbjct: 385 LLNAN 389
Score = 38.9 bits (89), Expect = 0.016
Identities = 43/155 (27%), Positives = 67/155 (43%), Gaps = 22/155 (14%)
Query: 378 LTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQ 437
L L L NQ+S + G L L L+ N+L +P LF + +T LD+S NQ
Sbjct: 87 LRVLHLEDNQVSVIER--GAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQ 144
Query: 438 ISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQG-TSLTYLDLSSNW 496
I P A FR + +++L L+ + + D F+ L L L++N
Sbjct: 145 IQGIPRKA------------FRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNN- 191
Query: 497 GVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALD 531
N S + M ++ +LR LHS+ + D
Sbjct: 192 ---NISRILVTSFNHMPKIRTLR---LHSNHLYCD 220
Score = 36.6 bits (83), Expect = 0.080
Identities = 41/177 (23%), Positives = 76/177 (42%), Gaps = 22/177 (12%)
Query: 375 PGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMS 434
P LDL N ++ + L +LR+ +L NQ+ + G F + + + L ++
Sbjct: 60 PRNAERLDLDRNNITRITKMDFAG--LKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLN 117
Query: 435 HNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQG-TSLTYLDLS 493
N++ + P + F++ L L L + +P F+G T + L L
Sbjct: 118 KNKLQVLPE------------LLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLD 165
Query: 494 SNW--GVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCL 548
+N + +G+ L+D L++L+L N + S + F+ +R L L N L
Sbjct: 166 NNHISCIEDGAFRALRD----LEILTLNNNNI-SRILVTSFNHMPKIRTLRLHSNHL 217
Score = 30.4 bits (67), Expect = 5.7
Identities = 44/175 (25%), Positives = 72/175 (41%), Gaps = 22/175 (12%)
Query: 443 LPAASDRVGPPSCV-DFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWGVLNG 501
L AS GPP+ + S S+ G GL A+P + LD ++ +
Sbjct: 20 LALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKM 79
Query: 502 SLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLD---LSGNCLTTFPR--FGG 556
A L++ L+VL L + + ++ F +L+ L+ L+ N L P F
Sbjct: 80 DFAGLKN----LRVLHLED----NQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQS 131
Query: 557 SLALETLDLRRNSLTALPQKAVSEQLSRGL---RTIYLSQNPYDCCGVDGWGALQ 608
+ L LDL N + +P+KA RG+ + + L N C + AL+
Sbjct: 132 TPKLTRLDLSENQIQGIPRKAF-----RGITDVKNLQLDNNHISCIEDGAFRALR 181
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 85.9 bits (211), Expect = 1e-16
Identities = 145/543 (26%), Positives = 221/543 (40%), Gaps = 97/543 (17%)
Query: 57 PHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNC 116
P R + +A +K L N + + LS S H I + +E L L L N
Sbjct: 79 PGTRKKSSNAEVIKEL-NKCREENSMRLDLSKRSIH---ILPSSIKELTQLTELYLYSNK 134
Query: 117 LSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSV 176
L + A + L L L LS N+LT +L NL LR + L N + + V
Sbjct: 135 L----QSLPAEVGCLVNLMTLALSENSLTSLPDSL--DNLKKLRMLDLRHNKLREIPSVV 188
Query: 177 FEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCI-VDFG-LTRLRVLNVS 234
+ L+ L L L+ N I +E L++L L++ N + + + G L L L+V+
Sbjct: 189 YR-LDSLTTLYLRFNRITTVEKD-IKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVA 246
Query: 235 YNVLEWFLATGGEAAFELETLDLSHNQLLFFP-LLPQYSKLRTLLLRDNNMGFYRDLYNT 293
+N LE G ++ LDL HN+LL P + S L L LR N + +
Sbjct: 247 HNQLEHLPKEIGNCT-QITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRL--------S 297
Query: 294 SSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPS 353
+ PR + L + N+ N +L E SS L L L +++N FQ P G + +
Sbjct: 298 AIPRSLAKCSALEELNLENNNISTLPESLLSS-LVKLNSLTLARNCFQLYPVGGPSQFST 356
Query: 354 LSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQ 413
+ LN+ N + + L++L++ NQL+ L L G + + L NL++NQ
Sbjct: 357 IYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVEL---NLATNQ 413
Query: 414 LLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCG 473
L +P + + ++ L +S+N + P N+ LR L LE
Sbjct: 414 LTKIPEDV-SGLVSLEVLILSNNLLKKLP-------------HGLGNLRKLRELDLEENK 459
Query: 474 LGALPDCPFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFS 533
L +LP+ +A L+D LQ L L N
Sbjct: 460 LESLPN----------------------EIAYLKD----LQKLVLTN------------- 480
Query: 534 GFGNLRDLDLSGNCLTTFPRFGGSLA-LETLDLRRNSLTALPQKAVSEQLSRGLRTIYLS 592
N LTT PR G L L L L N LT LP++ + + L +YL+
Sbjct: 481 ------------NQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLE---NLEELYLN 525
Query: 593 QNP 595
NP
Sbjct: 526 DNP 528
Score = 52.0 bits (123), Expect = 2e-06
Identities = 67/242 (27%), Positives = 107/242 (44%), Gaps = 32/242 (13%)
Query: 378 LTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQ 437
LTEL L N+L L P CL +L LS N L +P L N + + LD+ HN+
Sbjct: 125 LTELYLYSNKLQSL---PAEVGCLVNLMTLALSENSLTSLPDSL-DNLKKLRMLDLRHNK 180
Query: 438 I-----------SLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTS 486
+ SL L +R+ D +N++ L LS+ + LP + +
Sbjct: 181 LREIPSVVYRLDSLTTLYLRFNRITTVE-KDIKNLSKLSMLSIRENKIKQLPAEIGELCN 239
Query: 487 LTYLDLSSNWGVLNGSLAPL-QDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSG 545
L LD++ N L L +++ Q+ +L H+ + L + GNL L G
Sbjct: 240 LITLDVAHN------QLEHLPKEIGNCTQITNLDLQ--HNELLDLPDT-IGNLSSLSRLG 290
Query: 546 ---NCLTTFPR-FGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGV 601
N L+ PR ALE L+L N+++ LP+ +S + L ++ L++N + V
Sbjct: 291 LRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVK--LNSLTLARNCFQLYPV 348
Query: 602 DG 603
G
Sbjct: 349 GG 350
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 85.1 bits (209), Expect = 2e-16
Identities = 98/366 (26%), Positives = 151/366 (41%), Gaps = 18/366 (4%)
Query: 5 PLWLCLGFHFLTVGWRNRSGTATAASQGV-CKLVGGAADCRGQSLASVPSSLPPHARMLT 63
PL C L V SG+AT C A C + +VP +P R+L
Sbjct: 18 PLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLD 77
Query: 64 LDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEE 123
L N +KTL +P LE L L+ + + GAF +LR+L L N L
Sbjct: 78 LGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLK---LI 134
Query: 124 TAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERL 183
L L +LD+S N + + M Q+L +L+S+ + N ++ + F GL L
Sbjct: 135 PLGVFTGLSNLTKLDISENKIV-ILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSL 193
Query: 184 RELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFG---LTRLRVLNVSYNVLEW 240
+L L++ + I A L L L L N+ I D+ L RL+VL +S+
Sbjct: 194 EQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLD 253
Query: 241 FLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPRE-- 298
+ L +L ++H L P Y +R L+ + F YN S E
Sbjct: 254 TMTPNCLYGLNLTSLSITHCNLTAVP----YLAVRHLVY----LRFLNLSYNPISTIEGS 305
Query: 299 MVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLN 358
M+ + L + +++ E ++ L LR L++S NQ L + + +L L
Sbjct: 306 MLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLI 365
Query: 359 LHQNCL 364
L N L
Sbjct: 366 LDSNPL 371
Score = 62.4 bits (150), Expect = 1e-09
Identities = 77/312 (24%), Positives = 126/312 (40%), Gaps = 45/312 (14%)
Query: 160 RSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPC 219
R + L N I L+ F L EL+L N + +E GAF+ L LR L L N L
Sbjct: 74 RLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKL 133
Query: 220 I---VDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFP--LLPQYSKL 274
I V GL+ L L++S N + L + + L++L++ N L++ + L
Sbjct: 134 IPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSL 193
Query: 275 RTLLLRDNNMGFYRDLYNTSSPREMVAQF---LLVDGNVTNITTVSLWEEFSSSDLADLR 331
L L N+ TS P E ++ +++ NI + ++S L L+
Sbjct: 194 EQLTLEKCNL--------TSIPTEALSHLHGLIVLRLRHLNINAI---RDYSFKRLYRLK 242
Query: 332 FLDMSQNQF------------------------QYLPDGFLRKMPSLSHLNLHQNCLMTL 367
L++S + +P +R + L LNL N + T+
Sbjct: 243 VLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTI 302
Query: 368 HIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARN 427
L E+ L QL+ + P L LR+ N+S NQL + +F + N
Sbjct: 303 EGSMLHELLRLQEIQLVGGQLAVVE--PYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 360
Query: 428 ITTLDMSHNQIS 439
+ TL + N ++
Sbjct: 361 LETLILDSNPLA 372
Score = 55.1 bits (131), Expect = 2e-07
Identities = 71/253 (28%), Positives = 111/253 (43%), Gaps = 44/253 (17%)
Query: 357 LNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLG 416
L+L +N + TL+ E L EL+L+ N +S + PG + L +LR L SN+L
Sbjct: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVE--PGAFNNLFNLRTLGLRSNRLKL 133
Query: 417 VPPGLFANARNITTLDMSHNQI------------SLCPLPAASDRVGPPSCVDFRNMASL 464
+P G+F N+T LD+S N+I +L L + + S F + SL
Sbjct: 134 IPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSL 193
Query: 465 RSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLH 524
L+LE C L ++P +L++L L VL LR++ +
Sbjct: 194 EQLTLEKCNLTSIPT-----EALSHLH--------------------GLIVLRLRHLNI- 227
Query: 525 SSFMALDFSGFGNLRDLDLS--GNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQL 582
++ F L+ L++S T P L L +L + +LTA+P AV +
Sbjct: 228 NAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLV 287
Query: 583 SRGLRTIYLSQNP 595
LR + LS NP
Sbjct: 288 Y--LRFLNLSYNP 298
Score = 42.4 bits (98), Expect = 0.001
Identities = 67/252 (26%), Positives = 106/252 (42%), Gaps = 30/252 (11%)
Query: 327 LADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHN 386
L++L LD+S+N+ L D + + +L L + N L+ + R +L +L L
Sbjct: 142 LSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKC 201
Query: 387 QLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAA 446
L+ + S L L + L + + F + L++SH P
Sbjct: 202 NLTS--IPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISH-------WPYL 252
Query: 447 SDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQG-TSLTYLDLSSN-WGVLNGSLA 504
P+C+ N L SLS+ C L A+P + L +L+LS N + GS+
Sbjct: 253 DTMT--PNCLYGLN---LTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSM- 306
Query: 505 PLQDVAPMLQVLSLRNMGLHSSFMAL----DFSGFGNLRDLDLSGNCLTTFPR--FGGSL 558
+ ++L L+ + L +A+ F G LR L++SGN LTT F
Sbjct: 307 -------LHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVG 359
Query: 559 ALETLDLRRNSL 570
LETL L N L
Sbjct: 360 NLETLILDSNPL 371
Score = 39.7 bits (91), Expect = 0.009
Identities = 46/178 (25%), Positives = 75/178 (42%), Gaps = 42/178 (23%)
Query: 405 RLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASL 464
RL +L N++ + FA+ ++ L+++ N +S P A F N+ +L
Sbjct: 74 RLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVE-PGA-----------FNNLFNL 121
Query: 465 RSLSLEGCGLGALPDCPFQGTS-LTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGL 523
R+L L L +P F G S LT LD+S N V+
Sbjct: 122 RTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVI------------------------ 157
Query: 524 HSSFMALDFSGFGNLRDLDLSGNCLT--TFPRFGGSLALETLDLRRNSLTALPQKAVS 579
+ F NL+ L++ N L + F G +LE L L + +LT++P +A+S
Sbjct: 158 ---LLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALS 212
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 85.1 bits (209), Expect = 2e-16
Identities = 86/310 (27%), Positives = 139/310 (44%), Gaps = 11/310 (3%)
Query: 61 MLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSEN 120
+L+L N + + +LQ YP LESL L S + I +F L+ L L +N ++
Sbjct: 124 LLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTL 182
Query: 121 YEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGL 180
E + L + L+ N ++ M + L L+ + L N I ++ F+GL
Sbjct: 183 --EAGCFDNLSSSLLVVKLNRNRMS--MIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGL 238
Query: 181 ERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVD---FGLTRLRVLNVSYNV 237
+ LR L +QRN I +++ GAF GL + L L NNL + +GL L+ L VS N
Sbjct: 239 DSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNA 298
Query: 238 LEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPR 297
+E E L LDLS+NQL L + + + LL N+G R +
Sbjct: 299 IERISPDAWEFCQRLSELDLSYNQL---TRLDESAFVGLSLLERLNLGDNRVTHIADGVF 355
Query: 298 EMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHL 357
++ +D I+ + + L L L + NQ + + + SL HL
Sbjct: 356 RFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHL 415
Query: 358 NLHQNCLMTL 367
+L+ N +M++
Sbjct: 416 DLNNNAIMSI 425
Score = 67.8 bits (164), Expect = 3e-11
Identities = 90/366 (24%), Positives = 162/366 (44%), Gaps = 48/366 (13%)
Query: 134 LRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYI 193
L+ + ++ N LTE + S++ +SL N I ++ + L LDL N I
Sbjct: 99 LQEVKMNYNELTE--IPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNII 156
Query: 194 FEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELE 253
EI+ +F + +L++LNL+ NN ++ G N+S ++L
Sbjct: 157 SEIKTSSFPRM-QLKYLNLS-NNRITTLEAGCFD----NLSSSLL--------------- 195
Query: 254 TLDLSHNQLLFFPLLPQYSKL---RTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNV 310
+ L+ N++ P P+ KL + L L+ N + L T + + + +
Sbjct: 196 VVKLNRNRMSMIP--PKIFKLPHLQFLELKRNRIKIVEGL--TFQGLDSLRSLKMQRNGI 251
Query: 311 TNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIR 370
+ + + + L ++ L++ N + G+L + L L + QN + +
Sbjct: 252 SKLKDGAFF------GLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPD 305
Query: 371 EHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITT 430
E L+ELDLS+NQL+ L + + L L NL N++ + G+F N+ T
Sbjct: 306 AWEFCQRLSELDLSYNQLTRLDESAFVG--LSLLERLNLGDNRVTHIADGVFRFLSNLQT 363
Query: 431 LDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQG-TSLTY 489
LD+ +N+IS + AS+ F + SL L L+G + ++ F G SL +
Sbjct: 364 LDLRNNEISWA-IEDASEA--------FAGLTSLTKLILQGNQIKSITKKAFIGLESLEH 414
Query: 490 LDLSSN 495
LDL++N
Sbjct: 415 LDLNNN 420
Score = 63.2 bits (152), Expect = 8e-10
Identities = 104/410 (25%), Positives = 147/410 (35%), Gaps = 86/410 (20%)
Query: 55 LPPHARMLTLDANPLKTLWNHSLQPYPLLES----------------------LSLHSCH 92
LPP +L N L WN SL+ L E LSL
Sbjct: 73 LPPDTAILDFSHNRLSN-WNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNI 131
Query: 93 LERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALM 152
+ I+ A Q L SL L N +SE + + L+ L+LS N +T A
Sbjct: 132 IPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQ----LKYLNLSNNRITTLEAGCF 187
Query: 153 LQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNL 212
SSL V L N + + +F+ L L+ L+L+RN I +EG F GL LR L +
Sbjct: 188 DNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKM 246
Query: 213 AFNNLPCIVD---FGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLP 269
N + + D FGL + E L+L HN L
Sbjct: 247 QRNGISKLKDGAFFGLNNM------------------------EELELEHNNLTRV---- 278
Query: 270 QYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLAD 329
N G+ L + Q L V N + WE
Sbjct: 279 -------------NKGWLYGL--------RMLQQLYVSQNAIERISPDAWEFCQR----- 312
Query: 330 LRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLS 389
L LD+S NQ L + + L LNL N + + L LDL +N++S
Sbjct: 313 LSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEIS 372
Query: 390 -ELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQI 438
+ A + L SL L NQ+ + F ++ LD+++N I
Sbjct: 373 WAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAI 422
Score = 52.8 bits (125), Expect = 1e-06
Identities = 63/192 (32%), Positives = 93/192 (48%), Gaps = 15/192 (7%)
Query: 62 LTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENY 121
L L+ N L + L +L+ L + +ERIS A++ L L L N L+
Sbjct: 268 LELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLD 327
Query: 122 EETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIM-RLDDS--VFE 178
E +A L L RL+L N +T +A + + LS+L+++ L N I ++D+ F
Sbjct: 328 E---SAFVGLSLLERLNLGDNRVTH-IADGVFRFLSNLQTLDLRNNEISWAIEDASEAFA 383
Query: 179 GLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVD--FGLTRLR--VLNVS 234
GL L +L LQ N I I AF GL L HL+L N + I + F T L+ +LN S
Sbjct: 384 GLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTS 443
Query: 235 YNV----LEWFL 242
+ L+W L
Sbjct: 444 SLLCDCHLKWLL 455
Score = 42.0 bits (97), Expect = 0.002
Identities = 63/239 (26%), Positives = 102/239 (42%), Gaps = 26/239 (10%)
Query: 381 LDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFAN-ARNITTLDMSHNQI- 438
LD SHN+LS +++ L S +L+ ++ N+L +P F NIT L + HN I
Sbjct: 80 LDFSHNRLSNWNIS--LES--QTLQEVKMNYNELTEIP--YFGEPTSNITLLSLVHNIIP 133
Query: 439 -----------SLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSL 487
+L L +S+ + F M L+ L+L + L F S
Sbjct: 134 EINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSS 192
Query: 488 TYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNC 547
+ L + N ++ + P P LQ L L+ + L F G +LR L + N
Sbjct: 193 SLLVVKLNRNRMS-MIPPKIFKLPHLQFLELKRNRI-KIVEGLTFQGLDSLRSLKMQRNG 250
Query: 548 LTTFP--RFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGW 604
++ F G +E L+L N+LT + + + R L+ +Y+SQN + D W
Sbjct: 251 ISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGL--RMLQQLYVSQNAIERISPDAW 307
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 84.3 bits (207), Expect = 3e-16
Identities = 116/447 (25%), Positives = 188/447 (42%), Gaps = 78/447 (17%)
Query: 57 PHARMLTLDANPL--KTLWNHSLQPYPLLESLSLHSCHLE-------RISRGAFQEQGHL 107
PH ++L L+ N L + L P LE L L +++ ISR F + L
Sbjct: 311 PHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRN-FSKLLSL 369
Query: 108 RSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGN 167
R+L L E E+ L LP L ++L N + + + + QN S+L + L+ N
Sbjct: 370 RALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQ-IDFKLFQNFSNLEIIYLSEN 428
Query: 168 TIMRL---------DDSVFEGLERLRE------------------------------LDL 188
I L + S F+ R R LDL
Sbjct: 429 RISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDL 488
Query: 189 QRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVD----FGLTRLRVLNVSYNVLEWFLAT 244
N IF I F+ L ++ LNL+ N+ ++ + ++ L+++ N L++ A+
Sbjct: 489 SLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNAS 548
Query: 245 GGEAAFELETLDLSHNQLLF--------FPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSP 296
+LE LDLS+N F + ++ L+ L L NN+ D YN S
Sbjct: 549 ALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLES- 607
Query: 297 REMVAQFLLVDGNVTNITTVSLWEEFSS------SDLADLRFLDMSQNQFQYLP-DGFLR 349
+ +V L+ GN +I LW + + L +L LD+S N+ +++P + FL
Sbjct: 608 KSLVE--LVFSGNRLDI----LWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLN 661
Query: 350 KMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNL 409
SL+ L+++ N L + + L LDL N+L L L L+ SLR L
Sbjct: 662 LPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL--LFLTDSLSDFTSSLRTLLL 719
Query: 410 SSNQLLGVPPGLFANARNITTLDMSHN 436
S N++ +P G + ++ LD+S N
Sbjct: 720 SHNRISHLPSGFLSEVSSLKHLDLSSN 746
Score = 81.3 bits (199), Expect = 3e-15
Identities = 156/648 (24%), Positives = 258/648 (39%), Gaps = 105/648 (16%)
Query: 48 LASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSL-------HSCHLERISRGA 100
L +PS LP L+L N + + + L++L L C I G
Sbjct: 137 LPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGV 196
Query: 101 FQEQGHLRSLVLGDNCLSENYEETAAALH------------------ALPGLRRLDLSGN 142
F+ +L L L N LS + ++L L L LDLSGN
Sbjct: 197 FETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGN 256
Query: 143 A----------------LTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLREL 186
+ ++ QNL+ LR ++L+ ++ +++ + F+ + L+ L
Sbjct: 257 CPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVL 316
Query: 187 DLQRNYIF-EIEGGAF-DGLAELRHLNLAFNNL----PCIVDFG-----LTRLRVLNVSY 235
DL+ NY+ EI GAF L L L+L+FN + P ++ L LR L++
Sbjct: 317 DLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRG 376
Query: 236 NVLEWFLATGGEAAFEL---ETLDLSHNQL--LFFPLLPQYSKLRTLLLRDNNMGFY--- 287
V + + +L T++L N + + F L +S L + L +N +
Sbjct: 377 YVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKD 436
Query: 288 -RDLY-NTSSPREMVAQFLLVD------GNVTNITTVSLWEEFSSSDLADLRFLDMSQNQ 339
R Y N+SS + + + D N + T + + ++ A LD+S N
Sbjct: 437 TRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKA----LDLSLNS 492
Query: 340 FQYLPDGFLRKMPSLSHLNLHQNC-LMTLHIREHEPPGALTELDLSHNQLSELHLAPGLA 398
++ +P ++ LNL N L E + LDL++N+L + A L
Sbjct: 493 IFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRL-DFDNASALT 551
Query: 399 SCLGSLRLFNLSSN----QLLGVPPGL--FANARNITTLDMSHNQI------------SL 440
L L + +LS N ++ GV L N N+ L++SHN I SL
Sbjct: 552 E-LSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSL 610
Query: 441 CPLPAASDRVGPPSCVD-------FRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLS 493
L + +R+ D F+ + +L L L L +P+ F + +L
Sbjct: 611 VELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELH 670
Query: 494 SNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGF-GNLRDLDLSGNCLTTFP 552
N +L L P L++L LR L F+ S F +LR L LS N ++ P
Sbjct: 671 INDNMLKFFNWTLLQQFPRLELLDLRGNKL--LFLTDSLSDFTSSLRTLLLSHNRISHLP 728
Query: 553 R--FGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDC 598
+L+ LDL N L + + A+ + + L + L NP++C
Sbjct: 729 SGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFEC 776
Score = 63.9 bits (154), Expect = 5e-10
Identities = 82/298 (27%), Positives = 125/298 (41%), Gaps = 40/298 (13%)
Query: 131 LPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQR 190
LP + L+LS N+ + ++ + ++ + L N + + S L L LDL
Sbjct: 504 LPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSY 563
Query: 191 N-YIFEIEGGA-----FDGLAELRHLNLAFNNLPCIVD-------------FGLTRLRVL 231
N + F I G L+ LNL+ NN+ + D F RL +L
Sbjct: 564 NSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDIL 623
Query: 232 NVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFP---LLPQYSKLRTLLLRDNNMGFYR 288
+N + + + L LDLS N+L P L + L L + DN + F+
Sbjct: 624 ---WNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFN 680
Query: 289 DLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFL 348
PR + L + GN T SL +F+SS LR L +S N+ +LP GFL
Sbjct: 681 WTLLQQFPR---LELLDLRGNKLLFLTDSL-SDFTSS----LRTLLLSHNRISHLPSGFL 732
Query: 349 RKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASC-LGSLR 405
++ SL HL+L N L T++ AL + + ELH P +C +G R
Sbjct: 733 SEVSSLKHLDLSSNLLKTIN------KSALETKTTTKLSMLELHGNPFECTCDIGDFR 784
Score = 60.1 bits (144), Expect = 7e-09
Identities = 134/568 (23%), Positives = 215/568 (37%), Gaps = 88/568 (15%)
Query: 41 ADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGA 100
A+C + L VP ++ + L L N + + N S Q L ++L+ H +
Sbjct: 47 AECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLN--HNPNVQH-- 102
Query: 101 FQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLR 160
+ G+ S T A L LR L L N L + + L SL
Sbjct: 103 --QNGN-------PGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLP----ESLT 149
Query: 161 SVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFE-------IEGGAFDGLAELRHLNLA 213
+SL N I + L L+ L L N F IE G F+ L L L+L+
Sbjct: 150 ELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLS 209
Query: 214 FNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHN-QLLF---FPLLP 269
FN+L + + LR L +S +++ + L LDLS N F FP +P
Sbjct: 210 FNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVP 269
Query: 270 ----QYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSS 325
+ ++ Y +L +TS + A F N+ ++ + L +
Sbjct: 270 CDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFK----NMPHLKVLDLEFNYLVG 325
Query: 326 DLADLRFLDMSQN------QFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALT 379
++A FL M F Y+ + + H+N+ +N L +R G +
Sbjct: 326 EIASGAFLTMLPRLEILDLSFNYIKGSYPQ------HINISRNFSKLLSLRALHLRGYVF 379
Query: 380 ELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQIS 439
+ +L + L P L++ NL N + + LF N N+ + +S N+IS
Sbjct: 380 Q-ELREDDFQPLMQLPNLST-------INLGINFIKQIDFKLFQNFSNLEIIYLSENRIS 431
Query: 440 LCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGAL---------PDCPFQGTSLTYL 490
PL + + S R++ RS E P C G +L L
Sbjct: 432 --PLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALD-L 488
Query: 491 DLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMAL---DFSGFGNLRDLDLSGNC 547
L+S + + L D+A + N+ +S+ L +FS +++ LDL+ N
Sbjct: 489 SLNSIFFIGPNQFENLPDIACL-------NLSANSNAQVLSGTEFSAIPHVKYLDLTNNR 541
Query: 548 LTTFPRFGGSLA------LETLDLRRNS 569
L F + A LE LDL NS
Sbjct: 542 LD----FDNASALTELSDLEVLDLSYNS 565
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 84.0 bits (206), Expect = 4e-16
Identities = 80/277 (28%), Positives = 132/277 (47%), Gaps = 35/277 (12%)
Query: 186 LDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFG----LTRLRVLNVSYNVLEWF 241
LDL +N IF ++ F L+ L+ LNL+ N + ++ L LR L+ S N L+
Sbjct: 498 LDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLL 557
Query: 242 LATGGEAAFELETLDLSHNQLLF--------FPLLPQYSKLRTLLLRDNNMGFYRDLYNT 293
+T E +LE LD+S N F L+ L++ DN++ ++
Sbjct: 558 HSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDI-------SS 610
Query: 294 SSPREMVAQFLLV---DGNVTNITTVSLWEEFSS------SDLADLRFLDMSQNQFQYLP 344
S+ R M ++ L GN ++ LW E + +L L LD+S+N +LP
Sbjct: 611 STSRTMESESLRTLEFRGNHLDV----LWREGDNRYLQLFKNLLKLEELDISKNSLSFLP 666
Query: 345 DGFLRKMP-SLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGS 403
G MP +L +L+L +N L + ++ + L LDLSHNQL+ + L++C S
Sbjct: 667 SGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTV--PERLSNCSRS 724
Query: 404 LRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISL 440
L+ L +NQ+ + +A + LD+S N+I +
Sbjct: 725 LKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQM 761
Score = 76.6 bits (187), Expect = 7e-14
Identities = 153/634 (24%), Positives = 252/634 (39%), Gaps = 120/634 (18%)
Query: 45 GQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSL-------HSCHLE-RI 96
G L +P LPP ++L+L+AN + ++ +L +E L L + C++ I
Sbjct: 136 GNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSI 195
Query: 97 SRGAFQEQGHLRSLVLGDN-----------CLSENY-------EETAAALHALPGLRRLD 138
+ AF L+ L L DN L+E Y + + L L+ LD
Sbjct: 196 EKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILD 255
Query: 139 LSGN-----------ALTEDMAALML-----QNLSSLRSVSLAGNTIMRLDDSVFEGLER 182
LSGN A ++ + L + L+ L+ + L N++ + F+ + +
Sbjct: 256 LSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINK 315
Query: 183 LRELDLQRNYIFEIEGGA--FDGLAELRHLNLAFN----------NLPCIVDF--GLTRL 228
L+ELDL +N++ + G A L L L+L+FN NL L L
Sbjct: 316 LQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKIL 375
Query: 229 RVLNVSYNVLEWFLATGGEAAFELETLDLSHN--QLLFFPLLPQYSKLRTLLLRDNNM-- 284
R+ + L+ F + LE LDL N ++ + Q+ +L+ + L N +
Sbjct: 376 RIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISP 435
Query: 285 -GFYRDLYNTSSPREMV----------AQFLLVDGNVTNITTVSLWEEFSSSDLADLRF- 332
G ++ S+ R V + D + + F S + + ++
Sbjct: 436 SGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYG 495
Query: 333 --LDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCL-MTLHIREHEPPGALTELDLSHNQLS 389
LD+S+N ++ + + L LNL N + TL+ E +P L LD S+N+L
Sbjct: 496 QTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLD 555
Query: 390 ELHLAPGLASCLGSLRLFNLSSNQLLGVPPGL------FANARNITTLDMSHNQISLCPL 443
LH L L + ++SSN G+ N + + L M+ N IS
Sbjct: 556 LLHST--AFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDIS---- 609
Query: 444 PAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWGVLNGSL 503
+++ R SLR+L G L L ++ YL L N L
Sbjct: 610 -SSTSRT--------MESESLRTLEFRGNHLDVL----WREGDNRYLQLFKN-------L 649
Query: 504 APLQDVAPMLQVLSLRNMGLHSSFMALDFSGF-GNLRDLDLSGNCLTTF--PRFGGSLAL 560
L+++ LS G+ F G NL++L L+ N L +F + L
Sbjct: 650 LKLEELDISKNSLSFLPSGV--------FDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNL 701
Query: 561 ETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQN 594
ETLDL N LT +P++ SR L+ + L N
Sbjct: 702 ETLDLSHNQLTTVPERL--SNCSRSLKNLILKNN 733
Score = 57.4 bits (137), Expect = 4e-08
Identities = 152/669 (22%), Positives = 237/669 (35%), Gaps = 149/669 (22%)
Query: 42 DCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQ---------------PYPL---- 82
DC + L +P +P + LTL N + + S P PL
Sbjct: 50 DCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKN 109
Query: 83 -------------------LESLSLHSCHLERISRGA---------------------FQ 102
L+SL L L I +G
Sbjct: 110 NMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLT 169
Query: 103 EQGHLRSLVLGDNCLSEN-----YEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLS 157
E ++ L LG NC N Y A L L+ L L N +T L S
Sbjct: 170 ELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLP----S 225
Query: 158 SLRSVSLAGNTIMRLDDSVFEGLERLRELDL-----------------QRNYIFEIEGGA 200
+L + L N I ++ + F L +L+ LDL + N +I A
Sbjct: 226 TLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNA 285
Query: 201 FDGLAELRHLNLAFNNLPCIVD---FGLTRLRVLNVSYNVLEWFLATGGEAAF-----EL 252
FD L EL+ L L N+L + + +L+ L++S N L + G+A F L
Sbjct: 286 FDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEI---GDAKFLHFLPSL 342
Query: 253 ETLDLSHNQLL-----FFPLLPQYSKLRTL-LLRDNNMGFYRDLYNTSSPREMVAQFLLV 306
LDLS N L L +S L++L +LR F SP + ++
Sbjct: 343 IQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVL 402
Query: 307 D--GNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHL-----NL 359
D N I +S++++F L+ +D+S N+ P G ++ S+ +
Sbjct: 403 DLGTNFIKIANLSMFKQFKR-----LKVIDLSVNKIS--PSGDSSEVGFCSNARTSVESY 455
Query: 360 HQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPP 419
L LH ++ ++ SC + +LS N + V
Sbjct: 456 EPQVLEQLHYFRYDKYARSCRFKNKEASFMSVN-----ESCYKYGQTLDLSKNSIFFVKS 510
Query: 420 GLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPD 479
F + + L++S N IS + +F+ +A LR L L L
Sbjct: 511 SDFQHLSFLKCLNLSGNLIS-----------QTLNGSEFQPLAELRYLDFSNNRLDLLHS 559
Query: 480 CPFQGT-SLTYLDLSSNWGVLNGS----LAPLQDVAPMLQVLSLRNMGLHSSFMALDFSG 534
F+ L LD+SSN + +LQ L + + + SS S
Sbjct: 560 TAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMES- 618
Query: 535 FGNLRDLDLSGNCLTTFPRFGGS---------LALETLDLRRNSLTALPQKAVSEQLSRG 585
+LR L+ GN L R G + L LE LD+ +NSL+ LP V + +
Sbjct: 619 -ESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLP-SGVFDGMPPN 676
Query: 586 LRTIYLSQN 594
L+ + L++N
Sbjct: 677 LKNLSLAKN 685
Score = 53.5 bits (127), Expect = 6e-07
Identities = 72/297 (24%), Positives = 117/297 (39%), Gaps = 44/297 (14%)
Query: 134 LRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRN-Y 192
L+ L+LSGN +++ + Q L+ LR + + N + L + FE L +L LD+ N +
Sbjct: 519 LKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSH 578
Query: 193 IFEIEG-----GAFDGLAELRHLNLAFNNLPCIVDFGL--TRLRVLNVSYNVLEWFLATG 245
F+ EG L L+ L + N++ + LR L N L+ G
Sbjct: 579 YFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREG 638
Query: 246 G-------EAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPRE 298
+ +LE LD+S N L F P G +L N S +
Sbjct: 639 DNRYLQLFKNLLKLEELDISKNSLSFLP-------------SGVFDGMPPNLKNLSLAKN 685
Query: 299 MVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLN 358
+ F W++ L +L LD+S NQ +P+ SL +L
Sbjct: 686 GLKSF--------------SWKKLQC--LKNLETLDLSHNQLTTVPERLSNCSRSLKNLI 729
Query: 359 LHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLL 415
L N + +L + L LDLS N++ + + L +L++ L N+ L
Sbjct: 730 LKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFL 786
Score = 31.6 bits (70), Expect = 2.6
Identities = 21/65 (32%), Positives = 36/65 (55%), Gaps = 3/65 (4%)
Query: 532 FSGFGNLRDLDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYL 591
FSG L+ L L GN L P+ G +L+ L L N++ ++ ++ ++E + + +YL
Sbjct: 123 FSGLTYLKSLYLDGNQLLEIPQ-GLPPSLQLLSLEANNIFSIRKENLTELAN--IEILYL 179
Query: 592 SQNPY 596
QN Y
Sbjct: 180 GQNCY 184
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 83.2 bits (204), Expect = 7e-16
Identities = 84/348 (24%), Positives = 138/348 (39%), Gaps = 41/348 (11%)
Query: 34 CKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHL 93
C + C + L ++P +P ++L L N LK++ YPLLE + L +
Sbjct: 34 CSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNII 93
Query: 94 ERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALML 153
+ GAF +LRSL L N L L L +LD+S N + + M
Sbjct: 94 ANVEPGAFNNLFNLRSLRLKGNRLK---LVPLGVFTGLSNLTKLDISENKIV-ILLDYMF 149
Query: 154 QNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGL-----AELR 208
Q+L +L+S+ + N ++ + F GL L +L L++ + + A L L+
Sbjct: 150 QDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLK 209
Query: 209 HLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLL 268
HLN+ NN+P L L+ L + Y L + L +L +++ L P L
Sbjct: 210 HLNI--NNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFL 267
Query: 269 P------------QYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTV 316
Y+ + T+ G + DL + AQ +
Sbjct: 268 AFKHLVYLTHLNLSYNPISTI-----EAGMFSDLIRLQELHIVGAQLRTI---------- 312
Query: 317 SLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCL 364
E S L LR L++SQN + L + +L L+++ N L
Sbjct: 313 ---EPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
Score = 53.1 bits (126), Expect = 8e-07
Identities = 43/134 (32%), Positives = 65/134 (48%), Gaps = 14/134 (10%)
Query: 357 LNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLG 416
L+L +N L +++ E L E+DLS N ++ + PG + L +LR L N+L
Sbjct: 62 LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVE--PGAFNNLFNLRSLRLKGNRLKL 119
Query: 417 VPPGLFANARNITTLDMSHNQI------------SLCPLPAASDRVGPPSCVDFRNMASL 464
VP G+F N+T LD+S N+I +L L + + S F + SL
Sbjct: 120 VPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSL 179
Query: 465 RSLSLEGCGLGALP 478
L+LE C L A+P
Sbjct: 180 EQLTLEKCNLTAVP 193
Score = 49.3 bits (116), Expect = 1e-05
Identities = 54/178 (30%), Positives = 80/178 (44%), Gaps = 42/178 (23%)
Query: 405 RLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASL 464
++ +LS N+L V P F + + +D+S N I+ V P + F N+ +L
Sbjct: 60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIA---------NVEPGA---FNNLFNL 107
Query: 465 RSLSLEGCGLGALPDCPFQGTS-LTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGL 523
RSL L+G L +P F G S LT LD+S N V+ +L L
Sbjct: 108 RSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVI---------------LLDYMFQDL 152
Query: 524 HSSFMALDFSGFGNLRDLDLSGNCLTTFPR--FGGSLALETLDLRRNSLTALPQKAVS 579
H NL+ L++ N L F G L+LE L L + +LTA+P +A+S
Sbjct: 153 H------------NLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALS 198
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 83.2 bits (204), Expect = 7e-16
Identities = 104/353 (29%), Positives = 154/353 (43%), Gaps = 67/353 (18%)
Query: 289 DLYNTSSPREMVA--QFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDG 346
DL+ T+ P + A Q LL+ N ++ ++ LA+L LD+SQN F D
Sbjct: 57 DLFLTAVPPALPAGTQTLLLQSN-----SIVRVDQSELGYLANLTELDLSQNSFSDARDC 111
Query: 347 FLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRL 406
+P L L+L +N L L +L EL L+HNQL +AP S L +L
Sbjct: 112 DFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQL--YRIAPRAFSGLSNLLR 169
Query: 407 FNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRS 466
+L+SN L + F N+ L + N++ A D ++FR +A+LRS
Sbjct: 170 LHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVD-----AILD-------MNFRPLANLRS 217
Query: 467 LSLEGCGLGALPDCPFQG-------------------------TSLTYLDLSSNWGVLNG 501
L L G L + D +G L +LDL+ N
Sbjct: 218 LVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKN------ 271
Query: 502 SLAPLQDVAP--MLQVLSLRNMGLHS--SFMALDFSGFGNLRD---LDLSGNCLTTF--P 552
PLQ V P +L L+ +GL++ +++D NL + LD++ N +F P
Sbjct: 272 ---PLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHP 328
Query: 553 R-FGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGW 604
R F +ETL L N+L+AL Q+ V E L L+ + L NP C V W
Sbjct: 329 RAFHHLPQMETLMLNNNALSALHQQTV-ESLP-NLQEVGLHGNPIRCDCVIRW 379
Score = 74.3 bits (181), Expect = 3e-13
Identities = 101/419 (24%), Positives = 159/419 (37%), Gaps = 46/419 (10%)
Query: 42 DCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAF 101
DC L +VP +LP + L L +N + R+ +
Sbjct: 54 DCNDLFLTAVPPALPAGTQTLLLQSN------------------------SIVRVDQSEL 89
Query: 102 QEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRS 161
+L L L N S+ + HALP L L L N LT + L+SL+
Sbjct: 90 GYLANLTELDLSQNSFSDARD---CDFHALPQLLSLHLEENQLTR-LEDHSFAGLASLQE 145
Query: 162 VSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIV 221
+ L N + R+ F GL L L L N + I+ F+ L L L + N + I+
Sbjct: 146 LYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAIL 205
Query: 222 DFG---LTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFP--LLPQYSKLRT 276
D L LR L ++ L E LE+L NQL P L Q L+
Sbjct: 206 DMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKF 265
Query: 277 LLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMS 336
L L N + P + L + + N+ + ++F+ +L +L LD++
Sbjct: 266 LDLNKNPL-------QRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDIT 318
Query: 337 QN-QFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAP 395
N + ++ +P + L L+ N L LH + E L E+ L N +
Sbjct: 319 NNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI-RCDCVI 377
Query: 396 GLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPS 454
A+ G+ F + L PP L + + ++ +++ LP S R PPS
Sbjct: 378 RWANATGTRVRFIEPQSTLCAEPPDL----QRLPVREVPFREMTDHCLPLISPRSFPPS 432
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 83.2 bits (204), Expect = 7e-16
Identities = 104/353 (29%), Positives = 154/353 (43%), Gaps = 67/353 (18%)
Query: 289 DLYNTSSPREMVA--QFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDG 346
DL+ T+ P + A Q LL+ N ++ ++ LA+L LD+SQN F D
Sbjct: 57 DLFLTAVPPALPAGTQTLLLQSN-----SIVRVDQSELGYLANLTELDLSQNSFSDARDC 111
Query: 347 FLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRL 406
+P L L+L +N L L +L EL L+HNQL +AP S L +L
Sbjct: 112 DFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQL--YRIAPRAFSGLSNLLR 169
Query: 407 FNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRS 466
+L+SN L + F N+ L + N++ A D ++FR +A+LRS
Sbjct: 170 LHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVD-----AILD-------MNFRPLANLRS 217
Query: 467 LSLEGCGLGALPDCPFQG-------------------------TSLTYLDLSSNWGVLNG 501
L L G L + D +G L +LDL+ N
Sbjct: 218 LVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKN------ 271
Query: 502 SLAPLQDVAP--MLQVLSLRNMGLHS--SFMALDFSGFGNLRD---LDLSGNCLTTF--P 552
PLQ V P +L L+ +GL++ +++D NL + LD++ N +F P
Sbjct: 272 ---PLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHP 328
Query: 553 R-FGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGW 604
R F +ETL L N+L+AL Q+ V E L L+ + L NP C V W
Sbjct: 329 RAFHHLPQMETLMLNNNALSALHQQTV-ESLP-NLQEVGLHGNPIRCDCVIRW 379
Score = 74.3 bits (181), Expect = 3e-13
Identities = 101/419 (24%), Positives = 159/419 (37%), Gaps = 46/419 (10%)
Query: 42 DCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAF 101
DC L +VP +LP + L L +N + R+ +
Sbjct: 54 DCNDLFLTAVPPALPAGTQTLLLQSN------------------------SIVRVDQSEL 89
Query: 102 QEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRS 161
+L L L N S+ + HALP L L L N LT + L+SL+
Sbjct: 90 GYLANLTELDLSQNSFSDARD---CDFHALPQLLSLHLEENQLTR-LEDHSFAGLASLQE 145
Query: 162 VSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIV 221
+ L N + R+ F GL L L L N + I+ F+ L L L + N + I+
Sbjct: 146 LYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAIL 205
Query: 222 DFG---LTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFP--LLPQYSKLRT 276
D L LR L ++ L E LE+L NQL P L Q L+
Sbjct: 206 DMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKF 265
Query: 277 LLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMS 336
L L N + P + L + + N+ + ++F+ +L +L LD++
Sbjct: 266 LDLNKNPL-------QRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDIT 318
Query: 337 QN-QFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAP 395
N + ++ +P + L L+ N L LH + E L E+ L N +
Sbjct: 319 NNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI-RCDCVI 377
Query: 396 GLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPS 454
A+ G+ F + L PP L + + ++ +++ LP S R PPS
Sbjct: 378 RWANATGTRVRFIEPQSTLCAEPPDL----QRLPVREVPFREMTDHCLPLISPRSFPPS 432
>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
Length = 1032
Score = 82.8 bits (203), Expect = 1e-15
Identities = 150/540 (27%), Positives = 217/540 (40%), Gaps = 81/540 (15%)
Query: 131 LPGLRRLDLSGNALTEDMAAL---------------MLQNLSSLRSVSLAGNTIMRLDDS 175
L LR LD+ GN D A +LS L + L +++ L+ S
Sbjct: 243 LTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNAS 302
Query: 176 VFEGLERLRELDLQRNYIFE--IEGGAFDGLAELRHLNLAFN--------NLPCIVDFG- 224
F GL LR LDL N++++ + AF GL +LR LNL+FN +L FG
Sbjct: 303 WFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGS 362
Query: 225 ---LTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHN-----QLLFFPLLPQYSKLRT 276
L L + + + L+ L+TL L N QL F P LR
Sbjct: 363 LVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFP---GLRY 419
Query: 277 LLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRF-LDM 335
+ L DN + +L T + + L G++ + E + + L F LD+
Sbjct: 420 VDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDL 479
Query: 336 SQNQFQYLPDGFLRKMPSLSHLNLHQNCL-MTLHIREHEPPGALTELDLSHNQLSELHLA 394
S+N + ++ L L L NC+ ++ + P L LDLSHN+L H
Sbjct: 480 SRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYH-- 537
Query: 395 PGLASCLGSLRLFNLSSN------QLLGVPPGLFANARNITTLDMSHNQISLCPLPAASD 448
+ L L +LS N Q +G A+ R + L ++HN I
Sbjct: 538 EHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNI--------HS 589
Query: 449 RVGPPSCVDFRNMASLRSLSLEGCGLG---ALPDCP---FQGTS-LTYLDLSSNWGVLNG 501
+V C SLR+L G LG A D FQG S L +LDLS N
Sbjct: 590 QVSQQLC-----STSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQN---RLH 641
Query: 502 SLAP--LQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSL- 558
+L P L+++ LQVL LR+ L + F L LDL+GN L GSL
Sbjct: 642 TLLPQTLRNLPKSLQVLRLRDNYL-AFFKWWSLHFLPKLEVLDLAGNQLKALT--NGSLP 698
Query: 559 ---ALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGALQHGQTVAD 615
L LD+ NS++ + S+ ++ LR + LS N +G L + D
Sbjct: 699 AGTRLRRLDVSCNSISFVAPGFFSK--AKELRELNLSANALKTVDHSWFGPLASALQILD 756
Score = 70.5 bits (171), Expect = 5e-12
Identities = 92/288 (31%), Positives = 124/288 (43%), Gaps = 33/288 (11%)
Query: 131 LPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQR 190
L L+ L LS N +++ + L+ L+ + L+ N + + F L RL LDL
Sbjct: 495 LSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSY 554
Query: 191 N-YIFEIEGGAFD-----GLAELRHLNLAFNNLPCIVDFGL--TRLRVLNVSYNVLEWFL 242
N F ++G + L LRHL+LA NN+ V L T LR L+ S N L
Sbjct: 555 NSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMW 614
Query: 243 ATGG------EAAFELETLDLSHNQLLFFPLLPQYSK-----LRTLLLRDNNMGFYRDLY 291
A G + L LDLS N+L LLPQ + L+ L LRDN + F++
Sbjct: 615 AEGDLYLHFFQGLSGLIWLDLSQNRL--HTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWS 672
Query: 292 NTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKM 351
P+ V L + +T SL LR LD+S N ++ GF K
Sbjct: 673 LHFLPKLEVLD--LAGNQLKALTNGSLPAG------TRLRRLDVSCNSISFVAPGFFSKA 724
Query: 352 PSLSHLNLHQNCLMTLHIREHEP-PGALTELDLSHNQLSELHLAPGLA 398
L LNL N L T+ P AL LD+S N LH A G A
Sbjct: 725 KELRELNLSANALKTVDHSWFGPLASALQILDVSAN---PLHCACGAA 769
Score = 67.4 bits (163), Expect = 4e-11
Identities = 168/657 (25%), Positives = 245/657 (37%), Gaps = 135/657 (20%)
Query: 49 ASVPSSLPPHARMLTLDANPLKTLWNHSLQ-PYPLLESLSLHSCHLERISRGAFQEQGHL 107
A +P L PH ++ + LK++ + S+ P + SLSL S + + F L
Sbjct: 31 AFLPCELQPHG-LVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSL 89
Query: 108 RSLVLGDNCLSENYEETAAALH---------ALPGLRRLDLSGNALTEDMAALMLQNLSS 158
R L L NC H A+P L L+LS N + A S
Sbjct: 90 RHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALP-----KS 144
Query: 159 LRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIF--------EIEGGAFDGLAELRHL 210
L S+SL+ I+ LD + GL LR L + N + E+ GA GL L HL
Sbjct: 145 LISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHL 204
Query: 211 NLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQL-------- 262
+L +NNL + + L L +SYN + L LD+ N
Sbjct: 205 SLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNP 264
Query: 263 -----LFFPLL-----PQYSKLRTLLLRDN-----NMGFYRDLYNTSSPREMVAQFLL-- 305
FP L S+L L+L+D+ N ++R L N ++ FL
Sbjct: 265 CMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNL-RVLDLSENFLYKC 323
Query: 306 -----VDGNVTNITTVSLWEEF-------------SSSDLADLRFLDMSQNQFQYLPDGF 347
+T + ++L + S L L+ LDM F+ L +
Sbjct: 324 ITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETT 383
Query: 348 LR---KMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLS--------------- 389
LR ++P L L L N + + L +DLS N++S
Sbjct: 384 LRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGG 443
Query: 390 -ELHLAPG---------------LASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDM 433
++ L PG +C +LS N L+ V P +FA ++ L +
Sbjct: 444 EKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRL 503
Query: 434 SHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPF-QGTSLTYLDL 492
SHN IS + F + L+ L L L + F + L LDL
Sbjct: 504 SHNCISQA-----------VNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDL 552
Query: 493 SSN---WGVLNGSLAPLQDVAPM--LQVLSLRNMGLHS---------SFMALDFSGFGNL 538
S N +G + G VA + L+ LSL + +HS S ALDFSG L
Sbjct: 553 SYNSQPFG-MQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSG-NAL 610
Query: 539 RDLDLSGNCLTTFPRFGGSLALETLDLRRNSL-TALPQKAVSEQLSRGLRTIYLSQN 594
+ G+ F F G L LDL +N L T LPQ L + L+ + L N
Sbjct: 611 GHMWAEGDLYLHF--FQGLSGLIWLDLSQNRLHTLLPQ--TLRNLPKSLQVLRLRDN 663
Score = 45.8 bits (107), Expect = 1e-04
Identities = 51/163 (31%), Positives = 68/163 (41%), Gaps = 31/163 (19%)
Query: 107 LRSLVLGDNCLSENYEETAAALH---ALPGLRRLDLSGNAL-----------TEDMAALM 152
LR+L N L + E LH L GL LDLS N L + + L
Sbjct: 600 LRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLR 659
Query: 153 LQN-------------LSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGG 199
L++ L L + LAGN + L + RLR LD+ N I + G
Sbjct: 660 LRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPG 719
Query: 200 AFDGLAELRHLNLAFNNLPCIVD--FG--LTRLRVLNVSYNVL 238
F ELR LNL+ N L + FG + L++L+VS N L
Sbjct: 720 FFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPL 762
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,454,616
Number of Sequences: 37866
Number of extensions: 1177939
Number of successful extensions: 5854
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 185
Number of HSP's successfully gapped in prelim test: 129
Number of HSP's that attempted gapping in prelim test: 2637
Number of HSP's gapped (non-prelim): 1570
length of query: 692
length of database: 18,247,518
effective HSP length: 109
effective length of query: 583
effective length of database: 14,120,124
effective search space: 8232032292
effective search space used: 8232032292
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.