Guide to the Human Genome
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Search of human proteins with 38093661

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38093661 eyes shut homolog isoform 3 [Homo sapiens]
         (594 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38093661 eyes shut homolog isoform 3 [Homo sapiens]               1301   0.0  
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]              1292   0.0  
gi|224451131 eyes shut homolog isoform 2 [Homo sapiens]              1290   0.0  
gi|116235485 delta-notch-like EGF repeat-containing transmembran...   181   1e-45
gi|148833508 notch1 preproprotein [Homo sapiens]                      162   6e-40
gi|4557679 jagged 1 precursor [Homo sapiens]                          157   2e-38
gi|24041035 notch 2 preproprotein [Homo sapiens]                      155   8e-38
gi|110735443 delta-like 1 [Homo sapiens]                              155   1e-37
gi|9506545 delta-like 4 protein precursor [Homo sapiens]              137   3e-32
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]               137   3e-32
gi|55770876 notch4 preproprotein [Homo sapiens]                       134   2e-31
gi|148886654 polydom [Homo sapiens]                                   134   2e-31
gi|134244285 Notch homolog 3 [Homo sapiens]                           132   9e-31
gi|41327708 crumbs homolog 1 precursor [Homo sapiens]                 128   1e-29
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]               127   2e-29
gi|122937283 6720455I24Rik homolog [Homo sapiens]                     121   2e-27
gi|112420992 crumbs homolog 2 [Homo sapiens]                          112   1e-24
gi|4759146 slit homolog 2 [Homo sapiens]                              108   2e-23
gi|188528675 slit homolog 1 [Homo sapiens]                            107   2e-23
gi|74136023 delta-like 1 homolog [Homo sapiens]                       105   2e-22
gi|11321571 slit homolog 3 [Homo sapiens]                             101   2e-21
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]     98   2e-20
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]    98   2e-20
gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]     98   2e-20
gi|24430141 fibrillin 1 precursor [Homo sapiens]                       97   3e-20
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]                 94   3e-19
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]                 94   3e-19
gi|46249414 latent transforming growth factor beta binding prote...    91   4e-18
gi|46249412 latent transforming growth factor beta binding prote...    91   4e-18
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]             87   3e-17

>gi|38093661 eyes shut homolog isoform 3 [Homo sapiens]
          Length = 594

 Score = 1301 bits (3367), Expect = 0.0
 Identities = 594/594 (100%), Positives = 594/594 (100%)

Query: 1   MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL 60
           MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL
Sbjct: 1   MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL 60

Query: 61  GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT 120
           GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT
Sbjct: 61  GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT 120

Query: 121 EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS 180
           EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS
Sbjct: 121 EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS 180

Query: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY 240
           EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY
Sbjct: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY 240

Query: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300
           ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS
Sbjct: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300

Query: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP 360
           LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP
Sbjct: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP 360

Query: 361 IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL 420
           IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL
Sbjct: 361 IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL 420

Query: 421 NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV 480
           NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV
Sbjct: 421 NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV 480

Query: 481 WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS 540
           WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS
Sbjct: 481 WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS 540

Query: 541 CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLCII 594
           CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLCII
Sbjct: 541 CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLCII 594


>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
          Length = 3144

 Score = 1292 bits (3344), Expect = 0.0
 Identities = 590/592 (99%), Positives = 590/592 (99%)

Query: 1   MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL 60
           MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL
Sbjct: 1   MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL 60

Query: 61  GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT 120
           GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT
Sbjct: 61  GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT 120

Query: 121 EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS 180
           EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS
Sbjct: 121 EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS 180

Query: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY 240
           EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY
Sbjct: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY 240

Query: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300
           ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS
Sbjct: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300

Query: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP 360
           LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP
Sbjct: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP 360

Query: 361 IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL 420
           IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL
Sbjct: 361 IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL 420

Query: 421 NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV 480
           NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV
Sbjct: 421 NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV 480

Query: 481 WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS 540
           WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS
Sbjct: 481 WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS 540

Query: 541 CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLC 592
           CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPR  C
Sbjct: 541 CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSC 592



 Score =  145 bits (367), Expect = 8e-35
 Identities = 118/471 (25%), Positives = 173/471 (36%), Gaps = 114/471 (24%)

Query: 197  TYSCHCQPPFSGKYC-QELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSE 255
            +Y C C   + G +C QE + C   PCKNN +C +  ++     Y C C   +TG+NCSE
Sbjct: 754  SYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKS-----YRCECTSGWTGQNCSE 808

Query: 256  IIGQCQPHVCFHGN--------------CSNITSNSFI---------------------- 279
             I +C    C +G               C  + +  F                       
Sbjct: 809  EINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLA 868

Query: 280  -------CECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETD 332
                   C C E+F G  CE+  K C+ L     G C +  + +   C  G S    E +
Sbjct: 869  LVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIE 928

Query: 333  VSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDY 392
            ++E S  PC+N   C+ ++N   C C P +    C+     C+  P  +   C      Y
Sbjct: 929  INECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGY 988

Query: 393  PCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG------------C 440
             C C  G+T  NCE  +D C  LS  CL++  C + I  +   C  G            C
Sbjct: 989  NCLCAPGYTGINCEINLDEC--LSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDC 1046

Query: 441  TKNPCWFLKNVYLIHQHLCYCGV-------------------TFHGICQDKGPAQFEYVW 481
              NPC   +   LI+++ C C                        G CQ K    F  + 
Sbjct: 1047 LSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQ-KSAHGFTCIC 1105

Query: 482  QLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSC 541
              G+ G+    C+  ID       NC E       PE N+            IC NG  C
Sbjct: 1106 PRGYTGA---YCEKSID-------NCAE-------PELNS-----------VICLNGGIC 1137

Query: 542  LSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLC 592
            + +     +   C   ++G     N  +   + C H A C+D IN   Y+C
Sbjct: 1138 V-DGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHIN--GYVC 1185



 Score =  140 bits (352), Expect = 4e-33
 Identities = 85/297 (28%), Positives = 129/297 (43%), Gaps = 36/297 (12%)

Query: 202 CQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQA---------YECVCHPPFTGK 251
           C P F G  C+ ++D C+  PCKN  +CI++  N+  Q          + C+C+P + G 
Sbjct: 669 CVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGI 728

Query: 252 NCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPN 311
            C + I  C  + C H +       S+ C C   + G FCE  +  C          C +
Sbjct: 729 RCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTD 788

Query: 312 SSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIK--ISNDVMCICSPIFTDLLCKS 369
              +Y  EC  G + QN   +++E    PC NG  C +  I    +C+C P++T   C  
Sbjct: 789 LYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQ 848

Query: 370 IQTSCESF--PLRNNATC-KKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCF 426
               C+    P RNN+TC    + +  C C   F  KNCE  +  C  LS  C +   C 
Sbjct: 849 RYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLS--CQDYGDCE 906

Query: 427 NIIGRFKYVCIPG------------CTKNPCWFLKN----VYLIHQHLCYCGVTFHG 467
           +++  F+ +C PG            C+  PC   KN    V L ++  C C   +HG
Sbjct: 907 DMVNNFRCICRPGFSGSLCEIEINECSSEPC---KNNGTCVDLTNRFFCNCEPEYHG 960



 Score =  116 bits (290), Expect = 7e-26
 Identities = 69/249 (27%), Positives = 108/249 (43%), Gaps = 17/249 (6%)

Query: 198  YSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
            Y+C C P ++G  C+  LD C  +PC ++G CI+   +     Y C C   F G +C   
Sbjct: 988  YNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINH-----YTCDCKSGFFGTHCETN 1042

Query: 257  IGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAY 316
               C  + C HG C+ +  N + C CD   +   C++    C S+     G C  S+  +
Sbjct: 1043 ANDCLSNPCLHGRCTELI-NEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGF 1101

Query: 317  TYECPKGSSSQNGETDVS-----EFSLVPCQNGTDCIKISNDVM-CICSPIFTDLLCKSI 370
            T  CP+G +    E  +      E + V C NG  C+        C C P F+   C+  
Sbjct: 1102 TCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEIN 1161

Query: 371  QTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIG 430
               C S P  + A C+     Y C C  G++  +CE  ++    +  +C++E    N  G
Sbjct: 1162 INECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELE---CIPNSCVHELCMENEPG 1218

Query: 431  RFKYVCIPG 439
                +C PG
Sbjct: 1219 S-TCLCTPG 1226



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 49/186 (26%), Positives = 79/186 (42%), Gaps = 20/186 (10%)

Query: 186  HGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVC 244
            HG+C        Y C C    +   C+ +++ C+  PC N G C           + C+C
Sbjct: 1053 HGRCTELI--NEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHG-----FTCIC 1105

Query: 245  HPPFTGKNCSEIIGQC-QPH----VCFHGN-CSNITSNSFICECDEQFSGPFCEVSAKPC 298
               +TG  C + I  C +P     +C +G  C +   ++F C C   FSG FCE++   C
Sbjct: 1106 PRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININEC 1165

Query: 299  VSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMC 356
             S        C +  + Y  +C  G S  + E   +E   +P  C +   C++      C
Sbjct: 1166 SSSPCLHGADCEDHINGYVCKCQPGWSGHHCE---NELECIPNSCVHEL-CMENEPGSTC 1221

Query: 357  ICSPIF 362
            +C+P F
Sbjct: 1222 LCTPGF 1227



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 79/374 (21%), Positives = 120/374 (32%), Gaps = 56/374 (14%)

Query: 222 CKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICE 281
           C N  SC+++    D Q Y  +C   + G    E     Q + C H        N   C 
Sbjct: 535 CANGCSCLSEE---DSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCS 591

Query: 282 CDEQFSGPFCEVSAKPCV-SLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVP 340
           C   + G  C V+   C+ +      G+C   S        +       E D  +     
Sbjct: 592 CSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSAS 651

Query: 341 CQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGF 400
           C+NGT    +       C P F    C+     C S P +N ATC     +Y C C+  F
Sbjct: 652 CKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPF 711

Query: 401 TEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWF---LKNVYLIHQH 457
              +    + +   + I C  +              I  C  N C      K+++L +Q 
Sbjct: 712 KVVDGFSCLCNPGYVGIRCEQD--------------IDDCILNACEHNSTCKDLHLSYQC 757

Query: 458 LCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQ--------GVIDAYFFLAANCTE 509
           +C                     W+  F   E  +C+           D Y      CT 
Sbjct: 758 VCLSD------------------WEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTS 799

Query: 510 DATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLE--NT 567
             T  N  E+ N       E   + C NG  C       ++  LC   + G    +  N 
Sbjct: 800 GWTGQNCSEEIN-------ECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNL 852

Query: 568 TDDQENECQHEAVC 581
            D   N C++ + C
Sbjct: 853 CDLLHNPCRNNSTC 866



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 33/116 (28%), Positives = 53/116 (45%), Gaps = 12/116 (10%)

Query: 183  CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKP-----CKNNGSCINKRENWD 236
            C   G C   A    ++C C   ++G YC++ +D C+        C N G C++   +  
Sbjct: 1088 CMNEGFCQKSAHG--FTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGH-- 1143

Query: 237  EQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCE 292
               ++C C P F+G+ C   I +C    C HG       N ++C+C   +SG  CE
Sbjct: 1144 --TFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCE 1197



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 24/76 (31%), Positives = 35/76 (46%), Gaps = 8/76 (10%)

Query: 217  CSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHG-NCSNITS 275
            C+   C+NNG+CI+  EN       C C   ++GK C      C+ + C +G  C   + 
Sbjct: 2339 CAHHLCRNNGTCISDNEN-----LFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSG 2391

Query: 276  NSFICECDEQFSGPFC 291
               +C C    SGP C
Sbjct: 2392 TDIVCLCPYGRSGPLC 2407



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 7/78 (8%)

Query: 216  ACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGN-CSNIT 274
            AC +  C+N G C       +   + C C P + G  C++ +  C  ++C H + C    
Sbjct: 2878 ACGYNTCRNGGEC-----TVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQ 2931

Query: 275  SNSFICECDEQFSGPFCE 292
            S S+ C C   + G +CE
Sbjct: 2932 SFSYSCLCTLGWVGRYCE 2949



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 24/80 (30%), Positives = 37/80 (46%), Gaps = 7/80 (8%)

Query: 183  CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242
            C  +G C+S+  ++   C C   +SGK CQ   +C   PC N  +C+ K          C
Sbjct: 2344 CRNNGTCISD--NENLFCECPRLYSGKLCQ-FASCENNPCGNGATCVPK----SGTDIVC 2396

Query: 243  VCHPPFTGKNCSEIIGQCQP 262
            +C    +G  C++ I   QP
Sbjct: 2397 LCPYGRSGPLCTDAINITQP 2416



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 25/86 (29%), Positives = 35/86 (40%), Gaps = 5/86 (5%)

Query: 329  GETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCE-----SFPLRNNA 383
            G+   S  SL+ C NG  CI+    V C C+  +    C    ++C+            A
Sbjct: 2607 GQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGA 2666

Query: 384  TCKKCEKDYPCSCISGFTEKNCEKAI 409
            TC      Y C C  G T   CE+A+
Sbjct: 2667 TCISLPHGYTCFCPLGTTGIYCEQAL 2692



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 3/71 (4%)

Query: 341  CQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATC-KKCEKDYPCSCISG 399
            C+N   CI  + ++ C C  +++  LC+    SCE+ P  N ATC  K   D  C C  G
Sbjct: 2344 CRNNGTCISDNENLFCECPRLYSGKLCQF--ASCENNPCGNGATCVPKSGTDIVCLCPYG 2401

Query: 400  FTEKNCEKAID 410
             +   C  AI+
Sbjct: 2402 RSGPLCTDAIN 2412



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 25/98 (25%), Positives = 34/98 (34%), Gaps = 22/98 (22%)

Query: 200  CHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQ 259
            CH  P            CS   C N G+CI    +       C C   + G  C+E +  
Sbjct: 2609 CHASP------------CSLMKCGNGGTCIESGTS-----VYCNCTTGWKGSFCTETVST 2651

Query: 260  CQ-----PHVCFHGNCSNITSNSFICECDEQFSGPFCE 292
            C      PH C  G       + + C C    +G +CE
Sbjct: 2652 CDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCE 2689



 Score = 38.5 bits (88), Expect = 0.018
 Identities = 19/71 (26%), Positives = 31/71 (43%), Gaps = 6/71 (8%)

Query: 183  CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242
            C   G+C       T+SC C P ++G  C +  +C    C +   CI  +      +Y C
Sbjct: 2884 CRNGGECTVNG--TTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQ----SFSYSC 2937

Query: 243  VCHPPFTGKNC 253
            +C   + G+ C
Sbjct: 2938 LCTLGWVGRYC 2948



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 30/125 (24%), Positives = 45/125 (36%), Gaps = 49/125 (39%)

Query: 250  GKNCSEI-IGQCQPHVCFH-GNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRG 307
            GKN     +  C  H+C + G C +   N F CEC   +SG  C+ ++            
Sbjct: 2328 GKNIENCHVPWCAHHLCRNNGTCISDNENLF-CECPRLYSGKLCQFAS------------ 2374

Query: 308  ICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI-KISNDVMCIC-----SPI 361
             C N+                           PC NG  C+ K   D++C+C      P+
Sbjct: 2375 -CENN---------------------------PCGNGATCVPKSGTDIVCLCPYGRSGPL 2406

Query: 362  FTDLL 366
             TD +
Sbjct: 2407 CTDAI 2411



 Score = 33.5 bits (75), Expect = 0.57
 Identities = 21/101 (20%), Positives = 33/101 (32%)

Query: 306  RGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDL 365
            R +  N+      E      S  G+ D +      C+NG +C        C C P +   
Sbjct: 2849 RQVIINNQELQLTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGN 2908

Query: 366  LCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
             C    +   +  L  +         Y C C  G+  + CE
Sbjct: 2909 TCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 17/41 (41%), Positives = 21/41 (51%), Gaps = 5/41 (12%)

Query: 260  CQPHVCFHGN-CSNITSNS----FICECDEQFSGPFCEVSA 295
            CQ  VC +G  C  I  +S    F C+C   F+G FCE  A
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDA 2143



 Score = 30.0 bits (66), Expect = 6.3
 Identities = 22/84 (26%), Positives = 29/84 (34%), Gaps = 10/84 (11%)

Query: 252  NCSEIIGQCQPHVCFHGNCSN-----ITSNSFICECDEQFSGPFCEVSAKPC----VSLL 302
            N    +GQC    C    C N      +  S  C C   + G FC  +   C        
Sbjct: 2601 NAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPH 2660

Query: 303  FWKRG-ICPNSSSAYTYECPKGSS 325
               RG  C +    YT  CP G++
Sbjct: 2661 HCSRGATCISLPHGYTCFCPLGTT 2684


>gi|224451131 eyes shut homolog isoform 2 [Homo sapiens]
          Length = 619

 Score = 1290 bits (3339), Expect = 0.0
 Identities = 589/589 (100%), Positives = 589/589 (100%)

Query: 1   MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL 60
           MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL
Sbjct: 1   MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL 60

Query: 61  GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT 120
           GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT
Sbjct: 61  GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT 120

Query: 121 EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS 180
           EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS
Sbjct: 121 EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS 180

Query: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY 240
           EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY
Sbjct: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY 240

Query: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300
           ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS
Sbjct: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300

Query: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP 360
           LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP
Sbjct: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP 360

Query: 361 IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL 420
           IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL
Sbjct: 361 IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL 420

Query: 421 NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV 480
           NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV
Sbjct: 421 NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV 480

Query: 481 WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS 540
           WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS
Sbjct: 481 WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS 540

Query: 541 CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPR 589
           CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPR
Sbjct: 541 CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPR 589


>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
           [Homo sapiens]
          Length = 737

 Score =  181 bits (460), Expect = 1e-45
 Identities = 105/348 (30%), Positives = 160/348 (45%), Gaps = 9/348 (2%)

Query: 101 INLMNVSETSFVGCVQNTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCP 160
           I L  V+ T F  C   +  + + +   +  G   +  + L++G ++FI  +    +   
Sbjct: 237 ILLWKVTATGFQQC---SLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSI 293

Query: 161 LGLRLNVTVKQQFCQ--ESLSSEF-CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDAC 217
           + LRL + VK   C   ES +++  CSG GKC ++    T+SC C+  + G +C+E DAC
Sbjct: 294 VALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDAC 353

Query: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
             KPC+NN SCI+  E  D   + CVC P +TG+ C   I  C    C +G     + + 
Sbjct: 354 QRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSG 413

Query: 278 FICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFS 337
           F C+C E + G  CE    PC S      G C      +T  C  G +       +   +
Sbjct: 414 FTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCA 473

Query: 338 LVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCI 397
           L PC +GT C  +     C+C P +  L C+     C S P  N ATC+     Y C C+
Sbjct: 474 LSPCAHGT-CRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCL 532

Query: 398 SGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPC 445
           + +   +CE   D C   +++CLN   C +       +C PG T   C
Sbjct: 533 AEYKGTHCELYKDPC--ANVSCLNGATCDSDGLNGTCICAPGFTGEEC 578



 Score =  119 bits (297), Expect = 1e-26
 Identities = 66/225 (29%), Positives = 95/225 (42%), Gaps = 9/225 (4%)

Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKRENWDEQAYE 241
           C     C+S      ++C C   + G  C+E +D C+  PC+NNG+C       D   + 
Sbjct: 401 CRNGATCISSL--SGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYV-----DGVHFT 453

Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
           C C P FTG  C+++I  C    C HG C ++   S+ C CD  + G +CE     C+S 
Sbjct: 454 CNCSPGFTGPTCAQLIDFCALSPCAHGTCRSV-GTSYKCLCDPGYHGLYCEEEYNECLSA 512

Query: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
                  C +  + Y   C       + E      + V C NG  C     +  CIC+P 
Sbjct: 513 PCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPG 572

Query: 362 FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
           FT   C      C+S P  +  +C      Y C C  G+   NCE
Sbjct: 573 FTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 49/189 (25%), Positives = 83/189 (43%), Gaps = 12/189 (6%)

Query: 174 CQESL---SSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQEL-DACSFKPCKNNGSCI 229
           C+E +   +S  C  +G C  +     ++C+C P F+G  C +L D C+  PC + G+C 
Sbjct: 427 CEEKVDPCASSPCQNNGTCYVDGVH--FTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCR 483

Query: 230 NKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
           +   +     Y+C+C P + G  C E   +C    C +        N + C C  ++ G 
Sbjct: 484 SVGTS-----YKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGT 538

Query: 290 FCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIK 349
            CE+   PC ++       C +     T  C  G + +  + D++E    PC +G  C+ 
Sbjct: 539 HCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLD 598

Query: 350 ISNDVMCIC 358
             N   C C
Sbjct: 599 QPNGYNCHC 607



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 34/104 (32%), Positives = 51/104 (49%), Gaps = 11/104 (10%)

Query: 217 CSFKPCKNNGSCINKREN-------WDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGN 269
           C+ +PC+N G C ++ E          E  Y C C    +G NC  +   C  + C HGN
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 270 CSNITSNS---FICECDEQFSGPFCEVSAKPCVSLLFWKRGICP 310
           CS+ +S+S   ++C C+E + GP CE  A P +    W   + P
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCE-QALPSLPATGWTESMAP 150



 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 46/165 (27%), Positives = 60/165 (36%), Gaps = 47/165 (28%)

Query: 181 EFCS----GHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKN----------- 224
           +FC+     HG C S   S  Y C C P + G YC+E  + C   PC N           
Sbjct: 470 DFCALSPCAHGTCRSVGTS--YKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGY 527

Query: 225 ---------------------NGSCINKRE-NWDEQAYECVCHPPFTGKNCSEIIGQCQP 262
                                N SC+N    + D     C+C P FTG+ C   I +C  
Sbjct: 528 ECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDS 587

Query: 263 HVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRG 307
           + C HG       N + C C   + G  CE+        L WK G
Sbjct: 588 NPCHHGGSCLDQPNGYNCHCPHGWVGANCEIH-------LQWKSG 625



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 3/61 (4%)

Query: 198 YSCHCQPPFSGKYCQEL-DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
           YSC C    SG  CQ + D C+  PC ++G+C +   +     Y C+C+  + G NC + 
Sbjct: 78  YSCTCPAGISGANCQLVADPCASNPC-HHGNCSSSSSS-SSDGYLCICNEGYEGPNCEQA 135

Query: 257 I 257
           +
Sbjct: 136 L 136



 Score = 30.8 bits (68), Expect = 3.7
 Identities = 29/128 (22%), Positives = 42/128 (32%), Gaps = 21/128 (16%)

Query: 297 PCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND--- 353
           P ++LL    G  P  SS      P    S  G          PC+NG  C         
Sbjct: 15  PALALLLLLLGAGPRGSSLAN-PVPAAPLSAPGPCAAQ-----PCRNGGVCTSRPEPDPQ 68

Query: 354 ---------VMCICSPIFTDLLCKSIQTSCESFPLRN---NATCKKCEKDYPCSCISGFT 401
                      C C    +   C+ +   C S P  +   +++       Y C C  G+ 
Sbjct: 69  HPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYE 128

Query: 402 EKNCEKAI 409
             NCE+A+
Sbjct: 129 GPNCEQAL 136


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  162 bits (411), Expect = 6e-40
 Identities = 117/413 (28%), Positives = 159/413 (38%), Gaps = 44/413 (10%)

Query: 183  CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
            C   G C  +  +  Y C C+  FSG  CQ  ++ C+  PC N G+CI+     D   Y+
Sbjct: 762  CVNGGTC--KDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCID-----DVAGYK 814

Query: 242  CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSN--SFICECDEQFSGPFCEVSAKPCV 299
            C C  P+TG  C  ++  C P  C +G     + +  SF C C   + G  CEV    CV
Sbjct: 815  CNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECV 874

Query: 300  SLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICS 359
                     C N+   Y   C  G S +N ETD+ +    PC NG  C    N   C C 
Sbjct: 875  LSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCL 934

Query: 360  PIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINC 419
            P F    C+     C S P RN A C  C   Y C+C +GF+  +CE     C     +C
Sbjct: 935  PGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDC--TESSC 992

Query: 420  LNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEY 479
             N   C + I  F  +C PG T + C    +V       C  G    G CQD G   +  
Sbjct: 993  FNGGTCVDGINSFTCLCPPGFTGSYC--QHDVNECDSQPCLHG----GTCQD-GCGSYRC 1045

Query: 480  VWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGC 539
                G+    G  CQ ++         C       + P  N   CW  H   +  C +G 
Sbjct: 1046 TCPQGYT---GPNCQNLVHW-------CD------SSPCKNGGKCWQTHTQYRCECPSGW 1089

Query: 540  SCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLC 592
            + L         Y      +  +  +    D    CQH  +C D  N     C
Sbjct: 1090 TGL---------YCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRC 1133



 Score =  152 bits (384), Expect = 8e-37
 Identities = 109/410 (26%), Positives = 158/410 (38%), Gaps = 33/410 (8%)

Query: 198 YSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEII 257
           Y C C P +SGK CQ+ D C+  PC N G C+       E +Y C C P F G  C + +
Sbjct: 125 YKCRCPPGWSGKSCQQADPCASNPCANGGQCLPF-----EASYICHCPPSFHGPTCRQDV 179

Query: 258 GQC--QPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGIC-PNSSS 314
            +C  +P +C HG   +    S+ C C    +GP CE    PC        G C P    
Sbjct: 180 NECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDV 239

Query: 315 AYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSC 374
            +   C  G + QN E ++ +     C+NG  C+   N   C C P +T   C      C
Sbjct: 240 THECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDEC 299

Query: 375 ESFP--LRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRF 432
           +  P   +N  TC      Y C C++G+T ++C + ID C   S  C +   C + +  F
Sbjct: 300 QLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCA--SAACFHGATCHDRVASF 357

Query: 433 KYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEK 492
              C  G T   C             C       G   D  P   + +     +G  G  
Sbjct: 358 YCECPHGRTGLLCHL--------NDACISNPCNEGSNCDTNPVNGKAICTCP-SGYTGPA 408

Query: 493 CQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTK-EI---------CANGCSCL 542
           C   +D     A  C      +N        C   + G + EI         C N  +CL
Sbjct: 409 CSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCL 468

Query: 543 SEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLC 592
            +    E++ +C   + G     NT +   + C H   C D+IN  +  C
Sbjct: 469 DQIG--EFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCEC 516



 Score =  144 bits (362), Expect = 3e-34
 Identities = 107/427 (25%), Positives = 172/427 (40%), Gaps = 53/427 (12%)

Query: 187  GKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCH 245
            G CL +     Y C C+P ++G  C   +D C+  PC N G+C +         + C C 
Sbjct: 653  GTCLDKI--DGYECACEPGYTGSMCNINIDECAGNPCHNGGTCED-----GINGFTCRCP 705

Query: 246  PPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWK 305
              +    C   + +C  + C HG C + + N + C+CD  +SG  C+++   C S     
Sbjct: 706  EGYHDPTCLSEVNECNSNPCVHGACRD-SLNGYKCDCDPGWSGTNCDINNNECESNPCVN 764

Query: 306  RGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDL 365
             G C + +S Y   C +G S  N +T+++E +  PC N   CI       C C   +T  
Sbjct: 765  GGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGA 824

Query: 366  LCKSIQTSCESFPLRNNATCKKCE--KDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEE 423
             C+ +   C   P RN   C++ E  + + C C +G+  + CE  I+ C L    C +  
Sbjct: 825  TCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSP--CRHGA 882

Query: 424  WCFNIIGRFKYVC------------IPGCTKNPCWFLKN-VYLIHQHLCYCGVTFHG-IC 469
             C N  G ++  C            I  C  NPC    +    I+   C C   F G  C
Sbjct: 883  SCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFC 942

Query: 470  QDKGPAQFEYVWQLGFAGSE----GEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCW 525
            ++           +    S+    G  C   +D+Y      CT  A +     +NN+   
Sbjct: 943  EE----------DINECASDPCRNGANCTDCVDSY-----TCTCPAGFSGIHCENNTP-- 985

Query: 526  FPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEI 585
               + T+  C NG +C+   +S  +  LC   + G+    +  +     C H   C+D  
Sbjct: 986  ---DCTESSCFNGGTCVDGINS--FTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGC 1040

Query: 586  NRPRYLC 592
               R  C
Sbjct: 1041 GSYRCTC 1047



 Score =  143 bits (360), Expect = 5e-34
 Identities = 116/465 (24%), Positives = 169/465 (36%), Gaps = 76/465 (16%)

Query: 159  CPLGLR-LNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDA 216
            CP G   ++       C ES     C   G C+      +++C C P F+G YCQ +++ 
Sbjct: 971  CPAGFSGIHCENNTPDCTESS----CFNGGTCVDGI--NSFTCLCPPGFTGSYCQHDVNE 1024

Query: 217  CSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSN 276
            C  +PC + G+C +   +     Y C C   +TG NC  ++  C    C +G     T  
Sbjct: 1025 CDSQPCLHGGTCQDGCGS-----YRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHT 1079

Query: 277  SFICECDEQFSGPFCEVSAKPC----------VSLLFWKRGICPNSSSAYTYECPKGSSS 326
             + CEC   ++G +C+V +  C          V+ L    G+C ++ + +   C  G + 
Sbjct: 1080 QYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTG 1139

Query: 327  QNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCK 386
               E  V E S  PCQNG  C        C C   +  + C      C S P +N  TC 
Sbjct: 1140 SYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCL 1199

Query: 387  KCEKDYPCSCISGFTEKNCEKAIDHCK------LLSINCLNEEWCFNIIGRFKYVCIPG- 439
                 Y CSC  G    +CE  +D C         S  C N   C + +G +   C PG 
Sbjct: 1200 DLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGF 1259

Query: 440  -----------CTKNPC---WFLKNVYLIHQHLCYCGVTFHG-------------ICQDK 472
                       C  NPC        V  ++   C C     G              C++ 
Sbjct: 1260 VGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNG 1319

Query: 473  GPAQFEYVWQLGF-----AGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFP 527
            G          GF     AG EG  C+   DA    +  C    T ++ P      C  P
Sbjct: 1320 GTCAVASNTARGFICKCPAGFEGATCEN--DARTCGSLRCLNGGTCISGPRSPTCLCLGP 1377

Query: 528  HEGTK------------EICANGCSCLSEEDSQEYRYLCFLRWAG 560
              G +              C N  +C    +S  YR LC  ++ G
Sbjct: 1378 FTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNG 1422



 Score =  141 bits (355), Expect = 2e-33
 Identities = 108/427 (25%), Positives = 174/427 (40%), Gaps = 43/427 (10%)

Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKRENWDEQAYE 241
           C   G C       T+ C C P F+G+ C+E +D C    CKN G+C++         Y 
Sbjct: 227 CQNGGTCRPTG-DVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVD-----GVNTYN 280

Query: 242 CVCHPPFTGKNCSEIIGQCQ--PHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCV 299
           C C P +TG+ C+E + +CQ  P+ C +G   + T   + C C   ++G  C  +   C 
Sbjct: 281 CRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCA 340

Query: 300 SLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIK--ISNDVMCI 357
           S   +    C +  +++  ECP G +      + +  S  PC  G++C    ++   +C 
Sbjct: 341 SAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISN-PCNEGSNCDTNPVNGKAICT 399

Query: 358 CSPIFTDLLCKSIQTSCE--SFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLL 415
           C   +T   C      C   + P  +   C      + C C+ G+T   CE  ++ C  +
Sbjct: 400 CPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNEC--V 457

Query: 416 SINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFH-GICQDKGP 474
           S  C N+  C + IG F+ +C+PG     C        ++   C      H G C DK  
Sbjct: 458 SNPCQNDATCLDQIGEFQCICMPGYEGVHCE-------VNTDECASSPCLHNGRCLDK-I 509

Query: 475 AQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTK-E 533
            +F+     GF G     CQ  +D     +  C   A  ++ P      C   + GT  E
Sbjct: 510 NEFQCECPTGFTG---HLCQYDVDEC--ASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCE 564

Query: 534 ICANGC--------SCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEI 585
           +  + C        SC  ++    +  LC   + G+    N  +     C+H   C+D  
Sbjct: 565 VDIDECDPDPCHYGSC--KDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRD 622

Query: 586 NRPRYLC 592
           N   YLC
Sbjct: 623 N--AYLC 627



 Score =  135 bits (339), Expect = 1e-31
 Identities = 118/433 (27%), Positives = 168/433 (38%), Gaps = 43/433 (9%)

Query: 183 CSGHGKC--LSEAWSKTYSCHCQPPFSGKYC-QELD-ACSFKPCKNNGSCINKRENWDEQ 238
           C   G C  +       Y+C C   FSG  C   LD AC   PC+N G+C    +     
Sbjct: 68  CKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTC----DLLTLT 123

Query: 239 AYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPC 298
            Y+C C P ++GK+C +    C  + C +G        S+IC C   F GP C      C
Sbjct: 124 EYKCRCPPGWSGKSCQQA-DPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNEC 182

Query: 299 VSL--LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVM- 355
                L    G C N   +Y   C    +  N E      S  PCQNG  C + + DV  
Sbjct: 183 GQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTC-RPTGDVTH 241

Query: 356 -CICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKL 414
            C C P FT   C+     C     +N   C      Y C C   +T + C + +D C+L
Sbjct: 242 ECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQL 301

Query: 415 LSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGP 474
           +   C N   C N  G +  VC+ G T   C   +N+       C+ G T    C D+  
Sbjct: 302 MPNACQNGGTCHNTHGGYNCVCVNGWTGEDC--SENIDDCASAACFHGAT----CHDR-V 354

Query: 475 AQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEI 534
           A F         G  G  C  + DA   ++  C E +    +P +  + C  P   T   
Sbjct: 355 ASFYCECP---HGRTGLLCH-LNDA--CISNPCNEGSNCDTNPVNGKAICTCPSGYTGPA 408

Query: 535 C----------ANGC----SCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAV 580
           C          AN C     C++   S E +  C   + G     +  +   N CQ++A 
Sbjct: 409 CSQDVDECSLGANPCEHAGKCINTLGSFECQ--CLQGYTGPRCEIDVNECVSNPCQNDAT 466

Query: 581 CKDEINRPRYLCI 593
           C D+I   + +C+
Sbjct: 467 CLDQIGEFQCICM 479



 Score =  129 bits (325), Expect = 6e-30
 Identities = 112/436 (25%), Positives = 168/436 (38%), Gaps = 46/436 (10%)

Query: 174 CQESLSSEFCSGH-GKCLSEAWSKTYSCH-------CQPPF--SGKYCQELDACSFKPCK 223
           C    + E CS +   C S A     +CH       C+ P   +G  C   DAC   PC 
Sbjct: 323 CVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCN 382

Query: 224 NNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQ--PHVCFH-GNCSNITSNSFIC 280
              +C     N       C C   +TG  CS+ + +C    + C H G C N T  SF C
Sbjct: 383 EGSNCDTNPVNGKAI---CTCPSGYTGPACSQDVDECSLGANPCEHAGKCIN-TLGSFEC 438

Query: 281 ECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVP 340
           +C + ++GP CE+    CVS        C +    +   C  G    + E +  E +  P
Sbjct: 439 QCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSP 498

Query: 341 CQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGF 400
           C +   C+   N+  C C   FT  LC+     C S P +N A C      Y C C  G+
Sbjct: 499 CLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGY 558

Query: 401 TEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCY 460
           T  +CE  ID C     +  +   C + +  F  +C PG T + C    N+       C 
Sbjct: 559 TGTHCEVDIDEC---DPDPCHYGSCKDGVATFTCLCRPGYTGHHC--ETNINECSSQPCR 613

Query: 461 CGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDN 520
            G    G CQD+  A   +       G+ G  C+  +D     A++  +  T ++  +  
Sbjct: 614 HG----GTCQDRDNAYLCFC----LKGTTGPNCEINLDD---CASSPCDSGTCLDKIDGY 662

Query: 521 NSSCWFPHEGTK----------EICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDD 570
             +C   + G+             C NG +C  E+    +   C   +     L    + 
Sbjct: 663 ECACEPGYTGSMCNINIDECAGNPCHNGGTC--EDGINGFTCRCPEGYHDPTCLSEVNEC 720

Query: 571 QENECQHEAVCKDEIN 586
             N C H A C+D +N
Sbjct: 721 NSNPCVHGA-CRDSLN 735



 Score =  126 bits (317), Expect = 5e-29
 Identities = 83/297 (27%), Positives = 126/297 (42%), Gaps = 35/297 (11%)

Query: 198  YSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
            Y CHCQ  +SG+ C+ ++D C   PC N GSC +        A+ C C P F G  C E 
Sbjct: 891  YRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINT----AF-CDCLPGFRGTFCEED 945

Query: 257  IGQCQPHVCFHG-NCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSA 315
            I +C    C +G NC++   +S+ C C   FSG  CE +   C     +  G C +  ++
Sbjct: 946  INECASDPCRNGANCTDCV-DSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINS 1004

Query: 316  YTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCE 375
            +T  CP G +    + DV+E    PC +G  C        C C   +T   C+++   C+
Sbjct: 1005 FTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCD 1064

Query: 376  SFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKL-----------------LSIN 418
            S P +N   C +    Y C C SG+T   C+     C++                 L ++
Sbjct: 1065 SSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVD 1124

Query: 419  CLNEEWCFNIIGRFKYVC---IPGCTKNPCWFLKNVYLIHQHL----CYCGVTFHGI 468
              N   C    G     C   +  C+ +PC   +N      +L    C C   +HG+
Sbjct: 1125 AGNTHHCRCQAGYTGSYCEDLVDECSPSPC---QNGATCTDYLGGYSCKCVAGYHGV 1178



 Score = 30.0 bits (66), Expect = 6.3
 Identities = 45/173 (26%), Positives = 60/173 (34%), Gaps = 37/173 (21%)

Query: 154  SGP-SPCPLGLRLNVTVKQQFCQES--LSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKY 210
            SGP SP  L L      + QF   S  L    C   G C   + S  Y C C   F+G  
Sbjct: 1365 SGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLL 1424

Query: 211  CQELD------------------ACSFKPCKNNG-------SCINKRENWDEQAYECVCH 245
            C  LD                  AC    C+ +         C N    WD    +C  +
Sbjct: 1425 CHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWD--GGDCSLN 1482

Query: 246  PPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPC 298
                 KNC++ + QC  +    G+C +   NS  C     F G  C+ +   C
Sbjct: 1483 FNDPWKNCTQSL-QCWKYFS-DGHCDS-QCNSAGC----LFDGFDCQRAEGQC 1528


>gi|4557679 jagged 1 precursor [Homo sapiens]
          Length = 1218

 Score =  157 bits (398), Expect = 2e-38
 Identities = 117/428 (27%), Positives = 166/428 (38%), Gaps = 44/428 (10%)

Query: 172 QFCQESLSSEFCSGHGKCL-----SEAWSKTYSCHCQPPFSGKYCQELD-ACSFKPCKNN 225
           Q C + L+  +C  H  CL     S      Y C C   +SG  C+  + AC   PC N 
Sbjct: 291 QLCDKDLN--YCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNR 348

Query: 226 GSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQ 285
           GSC           +EC C P +TG  CS  I  C P+ C HG       N F C C  Q
Sbjct: 349 GSCKET-----SLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQ 403

Query: 286 FSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGT 345
           ++G  C++ A  C +        C N  ++Y  +C  G   QN + ++++  L  CQN  
Sbjct: 404 WTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININD-CLGQCQNDA 462

Query: 346 DCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNC 405
            C  + N   CIC P +    C+     C S P  N   C+     + C C +GF+   C
Sbjct: 463 SCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLC 522

Query: 406 EKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTF 465
           +  ID+C+     C N   C+N    +   C        C  LK+    H     C V  
Sbjct: 523 QLDIDYCE--PNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKD----HCRTTPCEVID 576

Query: 466 H---GICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATY----VNDPE 518
                +  +  P    Y+      G  G KC+      F    N     TY    +ND E
Sbjct: 577 SCTVAMASNDTPEGVRYI-SSNVCGPHG-KCKSQSGGKFTCDCNKGFTGTYCHENINDCE 634

Query: 519 DNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHE 578
            N              C NG +C+   +S  Y+ +C   W G     N  D  +N C + 
Sbjct: 635 SNP-------------CRNGGTCIDGVNS--YKCICSDGWEGAYCETNINDCSQNPCHNG 679

Query: 579 AVCKDEIN 586
             C+D +N
Sbjct: 680 GTCRDLVN 687



 Score =  152 bits (384), Expect = 8e-37
 Identities = 119/464 (25%), Positives = 186/464 (40%), Gaps = 82/464 (17%)

Query: 174 CQESLSSEFCSG-HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
           C  ++  + CS  HG C          C CQ  + G YC   D C   P   +G C    
Sbjct: 229 CNRAICRQGCSPKHGSCKLPG-----DCRCQYGWQGLYC---DKCIPHPGCVHGIC---- 276

Query: 233 ENWDEQAYECVCHPPFTGKNCSEIIGQCQPHV-CFHGN-CSNITSNSFICECDEQFSGPF 290
                + ++C+C   + G+ C + +  C  H  C +G  CSN   + + C C E +SGP 
Sbjct: 277 ----NEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPN 332

Query: 291 CEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKI 350
           CE++   C+S     RG C  +S  +  EC  G +     T++ + S   C +G  C  +
Sbjct: 333 CEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDL 392

Query: 351 SNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAID 410
            N   C+C P +T   C+     CE+ P  N  +CK     Y C C+ G+  +NC+  I+
Sbjct: 393 VNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININ 452

Query: 411 HCKLLSINCLNEEWCFNIIGRFKYVCIPG------------CTKNPCWFLKNVYL---IH 455
            C      C N+  C +++  ++ +C PG            C  NPC  L   +    I+
Sbjct: 453 DC---LGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPC--LNGGHCQNEIN 507

Query: 456 QHLCYCGVTFHG-ICQ------DKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCT 508
           +  C C   F G +CQ      +  P Q             G +C      YF     C 
Sbjct: 508 RFQCLCPTGFSGNLCQLDIDYCEPNPCQ------------NGAQCYNRASDYF---CKCP 552

Query: 509 ED-----ATYVND-----PEDNNSSCWF------PHEGTKEICANGC----SCLSEEDSQ 548
           ED      +++ D     P +   SC          EG + I +N C     C S+    
Sbjct: 553 EDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGG- 611

Query: 549 EYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLC 592
           ++   C   + G    EN  D + N C++   C D +N  + +C
Sbjct: 612 KFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCIC 655



 Score =  133 bits (335), Expect = 4e-31
 Identities = 112/440 (25%), Positives = 171/440 (38%), Gaps = 83/440 (18%)

Query: 187 GKCLSEAWSKT----YSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
           G+C ++A  +     Y C C P ++G +C+ ++D C+  PC N G C N+        ++
Sbjct: 456 GQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINR-----FQ 510

Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHG-NCSNITSNSFICECDEQFSGPFCE-----VSA 295
           C+C   F+G  C   I  C+P+ C +G  C N  S+ F C+C E + G  C         
Sbjct: 511 CLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYF-CKCPEDYEGKNCSHLKDHCRT 569

Query: 296 KPCV----------------------SLLFWKRGICPNSSSA-YTYECPKGSSSQNGETD 332
            PC                       S +    G C + S   +T +C KG +      +
Sbjct: 570 TPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHEN 629

Query: 333 VSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDY 392
           +++    PC+NG  CI   N   CICS  +    C++    C   P  N  TC+    D+
Sbjct: 630 INDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDF 689

Query: 393 PCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVY 452
            C C +G+  K C      C      C N   C++    FK +C  G     C   +N  
Sbjct: 690 YCDCKNGWKGKTCHSRDSQCD--EATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSS 747

Query: 453 LIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDAT 512
            +  + C+ G    G C   G + F  V + G+ G               + A  T D +
Sbjct: 748 CL-PNPCHNG----GTCVVNGES-FTCVCKEGWEGP--------------ICAQNTNDCS 787

Query: 513 YVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQE 572
                         PH      C N  +C+  ++   YR  C   +AG     N  + Q 
Sbjct: 788 --------------PHP-----CYNSGTCVDGDNW--YRCECAPGFAGPDCRININECQS 826

Query: 573 NECQHEAVCKDEINRPRYLC 592
           + C   A C DEIN  R +C
Sbjct: 827 SPCAFGATCVDEINGYRCVC 846



 Score =  124 bits (312), Expect = 2e-28
 Identities = 101/397 (25%), Positives = 147/397 (37%), Gaps = 49/397 (12%)

Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKREN 234
           +  +S  C   G C +E     + C C   FSG  CQ ++D C   PC+N   C N+  +
Sbjct: 489 DECASNPCLNGGHCQNEI--NRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASD 546

Query: 235 WDEQAYECVCHPPFTGKNCSEIIGQCQPHVCF---------------------------- 266
                Y C C   + GKNCS +   C+   C                             
Sbjct: 547 -----YFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGP 601

Query: 267 HGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSS 326
           HG C + +   F C+C++ F+G +C  +   C S      G C +  ++Y   C  G   
Sbjct: 602 HGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEG 661

Query: 327 QNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCK 386
              ET++++ S  PC NG  C  + ND  C C   +    C S  + C+     N  TC 
Sbjct: 662 AYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCY 721

Query: 387 KCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCW 446
                + C C  G+    C  A  +   L   C N   C      F  VC  G     C 
Sbjct: 722 DEGDAFKCMCPGGWEGTTCNIA-RNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPIC- 779

Query: 447 FLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAAN 506
             +N      H CY      G C D G   +      GFAG +   C+  I+     ++ 
Sbjct: 780 -AQNTNDCSPHPCYNS----GTCVD-GDNWYRCECAPGFAGPD---CR--ININECQSSP 828

Query: 507 CTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLS 543
           C   AT V++       C   H G K    +G  C++
Sbjct: 829 CAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCIT 865



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 30/93 (32%), Positives = 38/93 (40%), Gaps = 15/93 (16%)

Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242
           C+    C+ E     Y C C P  SG  CQE+   S +PC   GS I     WD+    C
Sbjct: 829 CAFGATCVDEI--NGYRCVCPPGHSGAKCQEV---SGRPCITMGSVIPDGAKWDDDCNTC 883

Query: 243 VCHPPFTGK-NCSEIIGQCQPHVCF----HGNC 270
            C     G+  CS++   C P  C     H  C
Sbjct: 884 QC---LNGRIACSKV--WCGPRPCLLHKGHSEC 911


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score =  155 bits (393), Expect = 8e-38
 Identities = 117/426 (27%), Positives = 174/426 (40%), Gaps = 49/426 (11%)

Query: 186  HGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVC 244
            HG C+       YSC C P F+G+ C  ++D C+  PC+   +CIN         + C+C
Sbjct: 656  HGICMDGI--NRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCIN-----GVNGFRCIC 708

Query: 245  HPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFW 304
                   +C   + +C  + C HGNC+   S  + C CD  + G  CEV    C+S    
Sbjct: 709  PEGPHHPSCYSQVNECLSNPCIHGNCTGGLSG-YKCLCDAGWVGINCEVDKNECLSNPCQ 767

Query: 305  KRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTD 364
              G C N  + Y   C KG    N + ++ E +  PC N   C    +   C C   +T 
Sbjct: 768  NGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTG 827

Query: 365  LLCKSIQTSCESFPLRNNATCKKCE--KDYPCSCISGFTEKNCEKAIDHCKLLSINCLNE 422
              C+++   C   P  N A CK+    + Y C C  G+  + C   ID C  +S  C+N 
Sbjct: 828  KNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDEC--ISKPCMNH 885

Query: 423  EWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQ 482
              C N  G +   C PG +   C   +++     + C  G    G C D G   F  +  
Sbjct: 886  GLCHNTQGSYMCECPPGFSGMDC--EEDIDDCLANPCQNG----GSCMD-GVNTFSCLCL 938

Query: 483  LGFAGSEGEKCQGVIDAYFFLAANCTEDAT---YVND-------------PEDNNSSCWF 526
             GF    G+KCQ   D    L+  C    T   YVN               E+N + C  
Sbjct: 939  PGFT---GDKCQ--TDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINEC-- 991

Query: 527  PHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
                T+  C NG +C+   +S  +  LC + + G+  L    +   + C +E  C D + 
Sbjct: 992  ----TESSCFNGGTCVDGINS--FSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLG 1045

Query: 587  RPRYLC 592
              R  C
Sbjct: 1046 TYRCSC 1051



 Score =  146 bits (369), Expect = 5e-35
 Identities = 121/459 (26%), Positives = 173/459 (37%), Gaps = 71/459 (15%)

Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242
           C+    C+    S  +SC C    +G  C   DAC   PC     C     N     Y C
Sbjct: 347 CTPGSTCIDRVAS--FSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQ---YIC 401

Query: 243 VCHPPFTGKNCSEIIGQC---QPHVCFH-GNCSNITSNSFICECDEQFSGPFCEVSAKPC 298
            C   + G +C+E + +C     + C H G C N T  +F CEC + ++GP CE+    C
Sbjct: 402 TCPQGYKGADCTEDVDECAMANSNPCEHAGKCVN-TDGAFHCECLKGYAGPRCEMDINEC 460

Query: 299 VSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCIC 358
            S        C +    +T  C  G    + E +++E    PC N   C+   N   C+C
Sbjct: 461 HSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLC 520

Query: 359 SPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHC------ 412
            P FT  +C+     C S P  N A C      Y C C +GFT   CE+ ID+C      
Sbjct: 521 PPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCH 580

Query: 413 -----------------------------KLLSINCLNEEWCFNIIGRFKYVCIPGCTKN 443
                                        +  S  CLN+  C +++  ++  C PG +  
Sbjct: 581 HGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGV 640

Query: 444 PCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFL 503
            C        I+   C      HGIC D G  ++  V   GF    G++C   ID     
Sbjct: 641 NC-------EINFDDCASNPCIHGICMD-GINRYSCVCSPGFT---GQRCNIDIDE---C 686

Query: 504 AAN-CTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS-CLSEE--------DSQEYRYL 553
           A+N C + AT +N    N   C  P       C +  + CLS              Y+ L
Sbjct: 687 ASNPCRKGATCINGV--NGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCL 744

Query: 554 CFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLC 592
           C   W G     +  +   N CQ+   C + +N  R  C
Sbjct: 745 CDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTC 783



 Score =  143 bits (360), Expect = 5e-34
 Identities = 115/441 (26%), Positives = 164/441 (37%), Gaps = 43/441 (9%)

Query: 174 CQESLS-----SEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSC 228
           CQ S S     S  C   G C   +   TY C CQ  F+GK CQ  DAC   PC N  +C
Sbjct: 101 CQYSTSHPCFVSRPCLNGGTCHMLS-RDTYECTCQVGFTGKECQWTDACLSHPCANGSTC 159

Query: 229 INKRENWDEQAYECVCHPPFTGKNCSEIIGQCQ-PHVCFHGNCSNITSNSFICECDEQFS 287
                      + C C   FTG+ C   + +C  P  C HG        S+ C+C + F+
Sbjct: 160 TTVANQ-----FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFT 214

Query: 288 GPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECP--KGSSSQNGETDVSEFSLVPCQNGT 345
           G +C+    PC        G C   +  +T+EC    G      E ++ +     CQNG 
Sbjct: 215 GQYCDSLYVPCAPSPCVNGGTC-RQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGG 273

Query: 346 DCIKISNDVMCICSPIFTDLLCKSIQTSCESFP--LRNNATCKKCEKDYPCSCISGFTEK 403
            C+   N   C C P +T   C      C   P   +N  TC      Y C C++G++  
Sbjct: 274 VCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGD 333

Query: 404 NCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIH-QHLCYCG 462
           +C + ID C   S  C     C + +  F  +C  G         K   L H    C   
Sbjct: 334 DCSENIDDCAFAS--CTPGSTCIDRVASFSCMCPEG---------KAGLLCHLDDACISN 382

Query: 463 VTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAAN-CTEDATYVNDPEDNN 521
               G   D  P   +Y+      G +G  C   +D      +N C      VN     +
Sbjct: 383 PCHKGALCDTNPLNGQYICTCP-QGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFH 441

Query: 522 SSCWFPHEGTK----------EICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQ 571
             C   + G +          + C N  +CL +     +  LC   + G        + Q
Sbjct: 442 CECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGG--FTCLCMPGFKGVHCELEINECQ 499

Query: 572 ENECQHEAVCKDEINRPRYLC 592
            N C +   C D++NR + LC
Sbjct: 500 SNPCVNNGQCVDKVNRFQCLC 520



 Score =  141 bits (355), Expect = 2e-33
 Identities = 109/421 (25%), Positives = 166/421 (39%), Gaps = 60/421 (14%)

Query: 183  CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
            C     C      ++Y+C C P + G+ C  ++D C  KPC N+G C N      + +Y 
Sbjct: 842  CENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNT-----QGSYM 896

Query: 242  CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
            C C P F+G +C E I  C  + C +G       N+F C C   F+G  C+     C+S 
Sbjct: 897  CECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSE 956

Query: 302  LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
                 G C +  ++YT +C  G    + E +++E +   C NG  C+   N   C+C   
Sbjct: 957  PCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVG 1016

Query: 362  FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLN 421
            FT   C      C S P  N  TC      Y CSC  G+T KNC+  ++ C      C N
Sbjct: 1017 FTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCS--RSPCKN 1074

Query: 422  EEWCFNIIGRFKYVCIPGCTKNPCWFLKNVY---------LIHQHLCYCGVTFHGICQDK 472
            +  C       + +C  G     C  + NV          ++ +HLC       G+C + 
Sbjct: 1075 KGTCVQKKAESQCLCPSGWAGAYC-DVPNVSCDIAASRRGVLVEHLC----QHSGVCINA 1129

Query: 473  GPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTK 532
            G   +     LG+ GS    C+  +D                              E   
Sbjct: 1130 GNTHY-CQCPLGYTGS---YCEEQLD------------------------------ECAS 1155

Query: 533  EICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENE-CQHEAVCKDEINRPRYL 591
              C +G +C   +    YR  C   + G +  E   D+ +N+ CQ+   C D +N  +  
Sbjct: 1156 NPCQHGATC--SDFIGGYRCECVPGYQG-VNCEYEVDECQNQPCQNGGTCIDLVNHFKCS 1212

Query: 592  C 592
            C
Sbjct: 1213 C 1213



 Score =  140 bits (353), Expect = 3e-33
 Identities = 112/429 (26%), Positives = 162/429 (37%), Gaps = 45/429 (10%)

Query: 180 SEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQ 238
           S+ C     CL +     ++C C P F G +C+ E++ C   PC NNG C++K       
Sbjct: 462 SDPCQNDATCLDKIGG--FTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNR---- 515

Query: 239 AYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAK-- 296
            ++C+C P FTG  C   I  C    C +G       N + C+C   F+G  CE +    
Sbjct: 516 -FQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNC 574

Query: 297 ---PCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND 353
              PC        G C +   +YT  C  G         + E    PC N   CI + N 
Sbjct: 575 DPDPC------HHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNG 628

Query: 354 VMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCK 413
             C C P  + + C+     C S P  +   C      Y C C  GFT + C   ID C 
Sbjct: 629 YQCNCQPGTSGVNCEINFDDCASNPCIHGI-CMDGINRYSCVCSPGFTGQRCNIDIDECA 687

Query: 414 LLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKG 473
             S  C     C N +  F+ +C  G     C+   N        C      HG C   G
Sbjct: 688 --SNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNE-------CLSNPCIHGNCTG-G 737

Query: 474 PAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTK- 532
            + ++ +   G+ G   E     +D    L+  C    T  N       +C    +G   
Sbjct: 738 LSGYKCLCDAGWVGINCE-----VDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNC 792

Query: 533 ----EICANGCSCLSE----EDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDE 584
               + CA+   CL++    +D   Y   C L + G            N C++ AVCK+ 
Sbjct: 793 QVNIDECASN-PCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKES 851

Query: 585 INRPRYLCI 593
            N   Y C+
Sbjct: 852 PNFESYTCL 860



 Score =  132 bits (333), Expect = 7e-31
 Identities = 114/433 (26%), Positives = 163/433 (37%), Gaps = 52/433 (12%)

Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA-CSFKPCKNNGSCINKRENWDEQAYE 241
           C   G CL+   S  Y C C   F+G+YC  L   C+  PC N G+C   R+  D   +E
Sbjct: 192 CQHGGTCLNLPGS--YQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTC---RQTGDF-TFE 245

Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCV-- 299
           C C P F G  C   I  C  H C +G       N++ C C  Q++G FC      C+  
Sbjct: 246 CNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQ 305

Query: 300 SLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICS 359
                  G C N +  Y   C  G S  +   ++ + +   C  G+ CI       C+C 
Sbjct: 306 PNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCP 365

Query: 360 PIFTDLLCKSIQTSCESFPLRNNATC--KKCEKDYPCSCISGFTEKNCEKAIDHCKLLSI 417
                LLC  +  +C S P    A C        Y C+C  G+   +C + +D C + + 
Sbjct: 366 EGKAGLLC-HLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANS 424

Query: 418 N-CLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQ 476
           N C +   C N  G F   C+ G     C    ++   H   C    T    C DK    
Sbjct: 425 NPCEHAGKCVNTDGAFHCECLKGYAGPRCEM--DINECHSDPCQNDAT----CLDK-IGG 477

Query: 477 FEYVWQLGFAGSEGE----KCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTK 532
           F  +   GF G   E    +CQ         +  C  +   V+  + N   C  P   T 
Sbjct: 478 FTCLCMPGFKGVHCELEINECQ---------SNPCVNNGQCVD--KVNRFQCLCPPGFTG 526

Query: 533 EI------------CANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAV 580
            +            C NG  C+   +   Y   C   + G +  EN  +   + C H   
Sbjct: 527 PVCQIDIDDCSSTPCLNGAKCIDHPNG--YECQCATGFTGVLCEENIDNCDPDPC-HHGQ 583

Query: 581 CKDEINRPRYLCI 593
           C+D I+   Y CI
Sbjct: 584 CQDGID--SYTCI 594



 Score =  130 bits (326), Expect = 4e-30
 Identities = 98/373 (26%), Positives = 157/373 (42%), Gaps = 36/373 (9%)

Query: 185 GHGKCLSEAWSKTYS-----CHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQA 239
           G+  C++E    TY      C C   F G+YCQ  D C    C+N G+C+ +        
Sbjct: 31  GYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKA-- 88

Query: 240 YECVCHPPFTGKNCSEIIGQCQPHVCF-------HGNCSNITSNSFICECDEQFSGPFCE 292
             C C   FTG++C         H CF        G C  ++ +++ C C   F+G  C+
Sbjct: 89  -TCRCASGFTGEDCQ----YSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ 143

Query: 293 VSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLV-PCQNGTDCIKIS 351
            +   C+S        C   ++ ++ +C  G + Q  ETDV+E  +   CQ+G  C+ + 
Sbjct: 144 WT-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLP 202

Query: 352 NDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKC-EKDYPCSCISGFTEKNCEKAID 410
               C C   FT   C S+   C   P  N  TC++  +  + C+C+ GF    CE+ ID
Sbjct: 203 GSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNID 262

Query: 411 HCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQ 470
            C   +  C N   C + +  +   C P  T   C    +  L+  + C  G    G C 
Sbjct: 263 DCP--NHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNG----GTCA 316

Query: 471 DKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEG 530
           ++    +  V   G++G +   C   ID   F  A+CT  +T ++     + SC  P   
Sbjct: 317 NRN-GGYGCVCVNGWSGDD---CSENIDDCAF--ASCTPGSTCID--RVASFSCMCPEGK 368

Query: 531 TKEICANGCSCLS 543
              +C    +C+S
Sbjct: 369 AGLLCHLDDACIS 381



 Score =  123 bits (309), Expect = 4e-28
 Identities = 80/306 (26%), Positives = 120/306 (39%), Gaps = 28/306 (9%)

Query: 178  LSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKRENWD 236
            L    C   G C++     T+ C C   ++G YC+E LD C+  PC++  +C +      
Sbjct: 1115 LVEHLCQHSGVCINAG--NTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGG-- 1170

Query: 237  EQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAK 296
               Y C C P + G NC   + +CQ   C +G       N F C C     G  CE +  
Sbjct: 1171 ---YRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENID 1227

Query: 297  PCV-SLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPC--QNGTDCIKISND 353
             C         G C +    Y+  C  G + +  E D++E    PC  +   DCI+++ND
Sbjct: 1228 DCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTND 1287

Query: 354  VMCICSPIFTDLLCKSIQTSCESFPLRNNATC---KKCEKDYPCSCISGFTEKNCEKAID 410
             +C+C   FT   C++    C   P  N  TC         + C C  GF+   C+ +  
Sbjct: 1288 YLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCG 1347

Query: 411  HCKLLSINCLNEEWCFNIIGRFKYV------CIPGCTKNPCWFLKNVYLIHQ---HLCYC 461
              K     C   E C +     +        C  GC  +PC    + +   Q   + C C
Sbjct: 1348 QVK-----CRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQC 1402

Query: 462  GVTFHG 467
               F G
Sbjct: 1403 APPFSG 1408



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 63/288 (21%), Positives = 103/288 (35%), Gaps = 69/288 (23%)

Query: 183  CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKRENWDEQAYE 241
            CS  G       +  Y C C+  F+G++C+  +D C   PC N G+C       D   + 
Sbjct: 1273 CSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPD--GFI 1330

Query: 242  CVCHPPFTGKNCSEIIGQ-----------------------------CQPHVCFHGNCSN 272
            C C P F+G  C    GQ                             C    C HG   +
Sbjct: 1331 CRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCH 1390

Query: 273  ITSNS--FICECDEQFSGPFCEVSAKP-------CVSLLFWKR---GICPNSSSAYTYEC 320
                   + C+C   FSG  CE+   P       C+S     +   G+C  + +++  + 
Sbjct: 1391 PQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQW 1450

Query: 321  PKGSSSQNGETDVSEFSL-VPCQN--GTDCIKISNDVMCICSPIFTDLLCKSIQTSCESF 377
              G  S   E   +  S  +PC +     C ++ N V C    +F +  C+         
Sbjct: 1451 DGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVEC----LFDNFECQG-------- 1498

Query: 378  PLRNNATCKKCEKDYPCSCISGFTEKNCEKAI--DHCKLLSINCLNEE 423
               N+ TCK     Y   C   F + +C++    + C    ++C  ++
Sbjct: 1499 ---NSKTCK-----YDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQ 1538



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 24/87 (27%), Positives = 35/87 (40%), Gaps = 5/87 (5%)

Query: 174  CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRE 233
            C+   +S  C   G C  +     YSC C PPFSG  C+   A    P     +C++  +
Sbjct: 1374 CESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTA---PPSTPPATCLS--Q 1428

Query: 234  NWDEQAYECVCHPPFTGKNCSEIIGQC 260
               ++A + VC        C    G C
Sbjct: 1429 YCADKARDGVCDEACNSHACQWDGGDC 1455


>gi|110735443 delta-like 1 [Homo sapiens]
          Length = 723

 Score =  155 bits (391), Expect = 1e-37
 Identities = 87/280 (31%), Positives = 123/280 (43%), Gaps = 15/280 (5%)

Query: 172 QFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDACSF-KPCKNNGSCI 229
           ++C E +    C  HG C      + + C+CQ  + G +C Q+L+ C+  KPCKN  +C 
Sbjct: 252 RYCDECIRYPGCL-HGTC-----QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCT 305

Query: 230 NKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
           N  +     +Y C C P +TG  C   I +C P  C +G       NS+ C C   F G 
Sbjct: 306 NTGQG----SYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGK 361

Query: 290 FCEVSAKPCVSLLFWKRGICPNS-SSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI 348
            CE+SA  C     +  G C +S    Y+  CP G S  N E  +   S  PC NG  C+
Sbjct: 362 ICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV 421

Query: 349 KISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKA 408
            + +  +C C   F+   C      C S P  N  TC+    D+ C+C  G+T +NC   
Sbjct: 422 DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAP 481

Query: 409 IDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFL 448
           +  C+     C N   C     R+   C  G     C FL
Sbjct: 482 VSRCE--HAPCHNGATCHERGHRYVCECARGYGGPNCQFL 519



 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 75/331 (22%), Positives = 111/331 (33%), Gaps = 72/331 (21%)

Query: 282 CDEQFSGPFCEVSAKP----CVSLLFWKRG--IC-PNSSSAYTYE--CPKGSSSQNGETD 332
           CDE + G  C V  +P           +RG  +C P     Y  E  C  G   Q+G  D
Sbjct: 179 CDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCD 238

Query: 333 VSEFSLVPCQNG------TDCIKISNDV--------MCICSPIFTDLLCKSIQTSCESF- 377
             +     C+ G       +CI+    +         C C   +  L C      C    
Sbjct: 239 --KPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHK 296

Query: 378 PLRNNATCKKC-EKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVC 436
           P +N ATC    +  Y CSC  G+T   CE  ID C      C N   C ++   +   C
Sbjct: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECD--PSPCKNGGSCTDLENSYSCTC 354

Query: 437 IPGCTKNPCWFLKNVYLIHQHLCYCGVTFH-GICQDKGPAQFEYVWQLGFAGSEGEKCQG 495
            PG       F   +  +    C  G  F+ G C D     +     +G++G        
Sbjct: 355 PPG-------FYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSG-------- 399

Query: 496 VIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCF 555
                     NC +   Y +                   C+NG  C+   D+  Y   C 
Sbjct: 400 ---------FNCEKKIDYCSSSP----------------CSNGAKCVDLGDA--YLCRCQ 432

Query: 556 LRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
             ++G    +N  D   + C +   C+D +N
Sbjct: 433 AGFSGRHCDDNVDDCASSPCANGGTCRDGVN 463



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 36/139 (25%), Positives = 52/139 (37%), Gaps = 41/139 (29%)

Query: 159 CPLGLR-LNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDA 216
           CP+G    N   K  +C    SS  CS   KC+       Y C CQ  FSG++C + +D 
Sbjct: 393 CPVGYSGFNCEKKIDYC----SSSPCSNGAKCVD--LGDAYLCRCQAGFSGRHCDDNVDD 446

Query: 217 CSFKPCKNNGSCINKRENWD-------------------EQA--------------YECV 243
           C+  PC N G+C +   ++                    E A              Y C 
Sbjct: 447 CASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCE 506

Query: 244 CHPPFTGKNCSEIIGQCQP 262
           C   + G NC  ++ +  P
Sbjct: 507 CARGYGGPNCQFLLPELPP 525


>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
          Length = 685

 Score =  137 bits (345), Expect = 3e-32
 Identities = 76/260 (29%), Positives = 111/260 (42%), Gaps = 12/260 (4%)

Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDACSF-KPCKNNGSCINKRENWDEQAY 240
           C  H  C     S  + C C   + G +C Q+L+ C+   PCKN  +C N      +++Y
Sbjct: 253 CIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNS----GQRSY 308

Query: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300
            C C P +TG +C   + +C  + C +G       + + C C   + G  CE S   C  
Sbjct: 309 TCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCAD 368

Query: 301 LLFWKRGICP--NSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCIC 358
              +  G C   N  + Y  ECP   +  N E  V   +  PC NG  C+      MC C
Sbjct: 369 SPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRC 428

Query: 359 SPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE--KAIDHCKLLS 416
            P FT   C+   + C   P  +  TC   E    C+C +GF+ + CE   +ID C   S
Sbjct: 429 RPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDAC--AS 486

Query: 417 INCLNEEWCFNIIGRFKYVC 436
             C N   C+  +    +VC
Sbjct: 487 SPCFNRATCYTDLSTDTFVC 506



 Score =  125 bits (313), Expect = 1e-28
 Identities = 86/284 (30%), Positives = 121/284 (42%), Gaps = 37/284 (13%)

Query: 202 CQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQ 261
           C P ++G+YCQ+   C     + NG C         +  EC+C P + G+ C+E    C 
Sbjct: 208 CLPGWTGEYCQQ-PICLSGCHEQNGYC--------SKPAECLCRPGWQGRLCNE----CI 254

Query: 262 PHV-CFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRG-ICPNSSS-AYTY 318
           PH  C HG CS      + C CDE + G FC+     C      K G  C NS   +YT 
Sbjct: 255 PHNGCRHGTCST----PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTC 310

Query: 319 ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFP 378
            C  G +  + E ++SE    PC+NG  C    +   C+C P +  L C+    SC   P
Sbjct: 311 TCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP 370

Query: 379 LRNNATCKKCEK--DYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFN--------- 427
             N  +C++  +  +Y C C   FT  NCEK +D C   S  C N   C N         
Sbjct: 371 CFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRC--TSNPCANGGQCLNRGPSRMCRC 428

Query: 428 ---IIGRFKYVCIPGCTKNPCWFLKNVYLIHQHL-CYCGVTFHG 467
                G +  + +  C +NPC      + +   L C C   F G
Sbjct: 429 RPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSG 472



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 36/119 (30%), Positives = 60/119 (50%), Gaps = 12/119 (10%)

Query: 179 SSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDE 237
           +S  C+  G+CL+   S+   C C+P F+G YC+  +  C+  PC + G+C +      E
Sbjct: 407 TSNPCANGGQCLNRGPSRM--CRCRPGFTGTYCELHVSDCARNPCAHGGTCHDL-----E 459

Query: 238 QAYECVCHPPFTGKNCS--EIIGQCQPHVCFH-GNC-SNITSNSFICECDEQFSGPFCE 292
               C C   F+G+ C     I  C    CF+   C +++++++F+C C   F G  CE
Sbjct: 460 NGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 57/262 (21%), Positives = 81/262 (30%), Gaps = 70/262 (26%)

Query: 388 CEKDYPCSCISGFTEKNCEKAI--DHCKLLSINCLNEEWCF---NIIGRFKYVCIP--GC 440
           C+ D   SC+ G+T + C++ I    C   +  C     C       GR    CIP  GC
Sbjct: 200 CQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGC 259

Query: 441 TKNPC---WFLK-----NVYLIHQHLCYCGVTFH------GICQDKGPAQFEYVWQLGFA 486
               C   W              Q L YC  T H        C + G   +    + G+ 
Sbjct: 260 RHGTCSTPWQCTCDEGWGGLFCDQDLNYC--THHSPCKNGATCSNSGQRSYTCTCRPGYT 317

Query: 487 GSE---------------GEKCQGVIDAYF------FLAANCTEDA-TYVNDPEDNNSSC 524
           G +               G  C+   D Y       +   +C     +  + P  N  SC
Sbjct: 318 GVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSC 377

Query: 525 WFPHEG-----------------------TKEICANGCSCLSEEDSQEYRYLCFLRWAGN 561
              ++G                       T   CANG  CL+   S+  R  C   + G 
Sbjct: 378 RERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCR--CRPGFTGT 435

Query: 562 MYLENTTDDQENECQHEAVCKD 583
               + +D   N C H   C D
Sbjct: 436 YCELHVSDCARNPCAHGGTCHD 457


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score =  137 bits (345), Expect = 3e-32
 Identities = 106/419 (25%), Positives = 161/419 (38%), Gaps = 37/419 (8%)

Query: 172 QFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDAC-SFKPCKNNGSCI 229
           +FC E +    C  HG C+ E W     C+C+  + G  C ++L+ C S  PC N G+CI
Sbjct: 271 RFCDECVPYPGCV-HGSCV-EPWQ----CNCETNWGGLLCDKDLNYCGSHHPCTNGGTCI 324

Query: 230 NKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
           N     +   Y C C   ++G+NC +    C  + C +G   +   + F C C   +SGP
Sbjct: 325 NA----EPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGP 380

Query: 290 FCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIK 349
            C +    C S      G C +    +   CP+       + DV++     CQ+G  C  
Sbjct: 381 TCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCR-GQCQHGGTCKD 439

Query: 350 ISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAI 409
           + N   C+C   F    C+  +  C S P  +   C+     + C C  GF+   CE  +
Sbjct: 440 LVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDV 499

Query: 410 DHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGV--TFHG 467
           D C+     C N   C+N+ G +   C        C        + +  C  G      G
Sbjct: 500 DLCE--PSPCRNGARCYNLEGDYYCACPDDFGGKNC-------SVPREPCPGGACRVIDG 550

Query: 468 ICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFP 527
              D GP         G  G  G +C       F    +     TY +   +N   C   
Sbjct: 551 CGSDAGPG-MPGTAASGVCGPHG-RCVSQPGGNFSCICDSGFTGTYCH---ENIDDC--- 602

Query: 528 HEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
                + C NG +C+ E D+  +R  C   W G +   N  D   + C     C D +N
Sbjct: 603 ---LGQPCRNGGTCIDEVDA--FRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVN 656



 Score =  132 bits (332), Expect = 9e-31
 Identities = 119/491 (24%), Positives = 172/491 (35%), Gaps = 96/491 (19%)

Query: 175 QESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRE 233
           + + +S  C+  G C        + CHC   +SG  C  ++D C+  PC   G+C+++ +
Sbjct: 348 EHACTSNPCANGGSC--HEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVD 405

Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEV 293
                 +EC+C   + G  C   +  C+   C HG       N + C C   F G  CE+
Sbjct: 406 G-----FECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCEL 459

Query: 294 SAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND 353
               C S      G+C + +  +   CP+G S    E DV      PC+NG  C  +  D
Sbjct: 460 ERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGD 519

Query: 354 VMCICSPIFTDLLCKSIQTSCESFPLRNNATCK--------------------KCEK--- 390
             C C   F    C   +  C     R    C                     +C     
Sbjct: 520 YYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPG 579

Query: 391 -DYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG---------- 439
            ++ C C SGFT   C + ID C  L   C N   C + +  F+  C  G          
Sbjct: 580 GNFSCICDSGFTGTYCHENIDDC--LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNP 637

Query: 440 --CTKNPCWFLKNVY-LIHQHLCYC-----GVTFH--------------GICQDKGPAQF 477
             C  +PC      Y L++   C C     G T H              G C D G   F
Sbjct: 638 NDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT-F 696

Query: 478 EYVWQLGFAGS----------------EGEKCQGVIDAYFFLAANCTEDATYVNDPEDNN 521
                 G+ GS                 G  C G   ++  +  +  E  T  ++  D N
Sbjct: 697 RCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCN 756

Query: 522 SSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVC 581
                P       C NG  C+  +    +R  C   +AG     N  + Q + C + A C
Sbjct: 757 P---LP-------CYNGGICV--DGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATC 804

Query: 582 KDEINRPRYLC 592
            DEIN  R  C
Sbjct: 805 VDEINGYRCSC 815



 Score =  127 bits (320), Expect = 2e-29
 Identities = 105/415 (25%), Positives = 148/415 (35%), Gaps = 65/415 (15%)

Query: 175 QESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRE 233
           ++  +S  C   G C  E  +  + CHC   FSG  C+ ++D C   PC+N   C N   
Sbjct: 461 RDECASSPCHSGGLC--EDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNL-- 516

Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCF------------------------HGN 269
              E  Y C C   F GKNCS     C    C                         HG 
Sbjct: 517 ---EGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGR 573

Query: 270 CSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNG 329
           C +    +F C CD  F+G +C  +   C+       G C +   A+   CP G   +  
Sbjct: 574 CVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 633

Query: 330 ETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCE 389
           +T+ ++    PC +   C  + ND  C C   +    C S +  C+++   N  TC    
Sbjct: 634 DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSG 693

Query: 390 KDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLK 449
             + C+C  G+    C  A  +   L   C+N   C      F  +C  G     C    
Sbjct: 694 DTFRCACPPGWKGSTCAVA-KNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTC--TH 750

Query: 450 NVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEG----EKCQGVIDAYFFLAA 505
           N    +   CY G    GIC D G   F      GFAG +     ++CQ    AY    A
Sbjct: 751 NTNDCNPLPCYNG----GICVD-GVNWFRCECAPGFAGPDCRINIDECQSSPCAY---GA 802

Query: 506 NCTED-------------ATYVNDPEDNNSSCW-----FPHEGTKEICANGCSCL 542
            C ++                  +      SCW     FPH  +     N C CL
Sbjct: 803 TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCL 857



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 56/234 (23%), Positives = 88/234 (37%), Gaps = 37/234 (15%)

Query: 388 CEKDYPCSCISGFTEKNCEKAI--DHCKLLSINCLNEEWC---FNIIGRFKYVCIP--GC 440
           C++    +C+ G+  K C++A+    C LL   C     C   +   GRF   C+P  GC
Sbjct: 223 CDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGC 282

Query: 441 TKNPC---WFLK-----NVYLIHQHLCYCG----VTFHGICQDKGPAQFEYVWQLGFAGS 488
               C   W           L  + L YCG     T  G C +  P Q+      G++G 
Sbjct: 283 VHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGR 342

Query: 489 EGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSC---WFPHEGTKEI-------CANG 538
             EK +     +   +  C    +    P      C   W       +I       CA G
Sbjct: 343 NCEKAE-----HACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAG 397

Query: 539 CSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLC 592
            +C+ + D   +  +C  +W G    +   +D   +CQH   CKD +N  + +C
Sbjct: 398 GTCVDQVDG--FECICPEQWVGAT-CQLDVNDCRGQCQHGGTCKDLVNGYQCVC 448


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score =  134 bits (338), Expect = 2e-31
 Identities = 119/467 (25%), Positives = 169/467 (36%), Gaps = 49/467 (10%)

Query: 157 SPCPLGLRLNVTVKQQF----CQESLSS----EFCSGHGKCLSEAWSKTYSCHCQPPFSG 208
           SP PL      T    F    CQ  L       FCS  G+C  +A  +   C C P ++G
Sbjct: 93  SPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRP-QCSCMPGWTG 151

Query: 209 KYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQC--QPHVCF 266
           + CQ  D CS  PC N G C+           +C C P F G  C   + +C   P  C 
Sbjct: 152 EQCQLRDFCSANPCVNGGVCLATYPQ-----IQCHCPPGFEGHACERDVNECFQDPGPCP 206

Query: 267 HGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGIC----PNSSSAYTYECPK 322
            G   + T  SF C C     GP CE+ A PC        G C       S+ +   CP 
Sbjct: 207 KGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPP 266

Query: 323 GSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESF---PL 379
           G    + E +        CQNG  C    +   C+C   +T   C      CE+      
Sbjct: 267 GFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHC 326

Query: 380 RNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
           RN  TC+     + C C+SG+   +CE+ +D C  ++  C     C + +G F  +C PG
Sbjct: 327 RNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDC--IAATCAPGSTCIDRVGSFSCLCPPG 384

Query: 440 CTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDA 499
            T   C         H          HG  Q            L   G  G  C   +D 
Sbjct: 385 RTGLLC---------HLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDE 435

Query: 500 YFFL---AANCTEDATYVNDPEDNNSSCWFPHEGTK----------EICANGCSCLSEED 546
                   + C    + +N P   N  C   + G++          + C  G +CL  + 
Sbjct: 436 CLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCL--DL 493

Query: 547 SQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLCI 593
              +  LC     G +    T +     C + A C D +N  + +C+
Sbjct: 494 LATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICL 540



 Score =  132 bits (331), Expect = 1e-30
 Identities = 106/410 (25%), Positives = 156/410 (38%), Gaps = 59/410 (14%)

Query: 174 CQESLS---SEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCIN 230
           C+E+L    +  C+    C+    S  +SC C P  +G  C   D C  +PC  +  C  
Sbjct: 352 CEENLDDCIAATCAPGSTCIDRVGS--FSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCST 409

Query: 231 KRENWDEQAYECVCHPPFTGKNCSEIIGQCQ-----PHVCFHGNCSNITSNSFICECDEQ 285
              N    +  C+C P ++G  C + + +C      P  C HG     T  SF C C   
Sbjct: 410 ---NPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPG 466

Query: 286 FSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGT 345
           ++G  CE     C+S        C +  + +   CP G   Q  E + +E +  PC N  
Sbjct: 467 YTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHA 526

Query: 346 DCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNC 405
           DC  + N   CIC P F+   C+     C S P  N   C+     + C C+ GF    C
Sbjct: 527 DCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRC 586

Query: 406 EKAIDHCKLLSINCLNEEWCFNIIGRFKYVC----------IPGCTKNPC---WFLKNVY 452
           +  +D C  LS  C     C ++ G F  +C          +P C  N C      K+  
Sbjct: 587 QTEVDEC--LSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQK 644

Query: 453 LIHQHLCYCG-----------VTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYF 501
                LC  G              HG CQ     +   V  +G+ G E   C+  +    
Sbjct: 645 DKANCLCPDGSPGCAPPEDNCTCHHGHCQ-----RSSCVCDVGWTGPE---CEAELGG-- 694

Query: 502 FLAANCTEDATYVNDPEDNNSSCWFPHEG---TKEI-------CANGCSC 541
            ++A C    T    P   N +C   + G   ++E+       C NG SC
Sbjct: 695 CISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSC 744



 Score =  129 bits (323), Expect = 1e-29
 Identities = 87/335 (25%), Positives = 132/335 (39%), Gaps = 29/335 (8%)

Query: 174  CQESLS---SEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQEL--DACSFKPCKNNGSC 228
            CQ S     S  C   G C++     T+SC C   F G  C+     +C+  PC+N  +C
Sbjct: 764  CQTSTDYCVSAPCFNGGTCVNRPG--TFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATC 821

Query: 229  INKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSG 288
             +       Q   C+C   +TG +C  ++  C    C   +    T  SF C C + ++G
Sbjct: 822  QDS-----PQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTG 876

Query: 289  PFCEVSAKPC----------VSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSL 338
            P C +    C          VS L    G+C +S  +Y   CP G      +  V+    
Sbjct: 877  PLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCES 936

Query: 339  VPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCIS 398
             PCQNG  C+   +  +C C+P +    C     +C+S P  N+ TC      + C+C  
Sbjct: 937  RPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPP 996

Query: 399  GFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHL 458
            GF    CE  +D C     +      C ++   F   C+PG T    W    +   H   
Sbjct: 997  GFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQ--WCEVEIDPCHSQP 1054

Query: 459  CYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKC 493
            C+ G    G C+    +   ++      G EG  C
Sbjct: 1055 CFHG----GTCEATAGSPLGFICHCP-KGFEGPTC 1084



 Score =  126 bits (316), Expect = 6e-29
 Identities = 120/502 (23%), Positives = 178/502 (35%), Gaps = 117/502 (23%)

Query: 156 PSPCPLGLRLNVTVKQQFC-----QESLSSEF---------CSGHGKC--LSEAWSKTYS 199
           P PCP G   + T+    C     QE    E          CS  G C  + E  S  + 
Sbjct: 202 PGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHL 261

Query: 200 CHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIG 258
           C C P F G  C+   D C    C+N G+C +  +      Y C+C   +TG +CSE + 
Sbjct: 262 CLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDT-----YTCLCPETWTGWDCSEDVD 316

Query: 259 QCQ----PHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSS 314
           +C+    PH    G C N ++ SF C C   + G  CE +   C++        C +   
Sbjct: 317 ECETQGPPHCRNGGTCQN-SAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVG 375

Query: 315 AYTYECPKG-------------SSSQNGETDVSEFSLV---------------------- 339
           +++  CP G             S   +G+   S   L                       
Sbjct: 376 SFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDE 435

Query: 340 ---------PCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEK 390
                    PC++G  C+       C+C P +T   C++    C S P    +TC     
Sbjct: 436 CLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLA 495

Query: 391 DYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKN 450
            + C C  G   + CE   + C   S  CLN   C +++  F+ +C+PG +   C   ++
Sbjct: 496 TFHCLCPPGLEGQLCEVETNECA--SAPCLNHADCHDLLNGFQCICLPGFSGTRCE--ED 551

Query: 451 VYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTED 510
           +       C  G    G CQD+ P  F      GF   EG +CQ  +D        C  D
Sbjct: 552 IDECRSSPCANG----GQCQDQ-PGAFHCKCLPGF---EGPRCQTEVD-------ECLSD 596

Query: 511 ATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDD 570
                                   C  G SCL    +    + C         L      
Sbjct: 597 P-----------------------CPVGASCLDLPGA----FFCLCPSGFTGQLCEVPLC 629

Query: 571 QENECQHEAVCKDEINRPRYLC 592
             N CQ + +CKD+ ++   LC
Sbjct: 630 APNLCQPKQICKDQKDKANCLC 651



 Score =  111 bits (278), Expect = 2e-24
 Identities = 85/336 (25%), Positives = 120/336 (35%), Gaps = 53/336 (15%)

Query: 174 CQESLS---SEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCI 229
           C+E +    S  C+  G+C  +  +  + C C P F G  CQ E+D C   PC    SC+
Sbjct: 548 CEEDIDECRSSPCANGGQCQDQPGA--FHCKCLPGFEGPRCQTEVDECLSDPCPVGASCL 605

Query: 230 NKRENWDEQAYECVCHPPFTGKNCSEII---GQCQPH----------------------- 263
           +        A+ C+C   FTG+ C   +     CQP                        
Sbjct: 606 DL-----PGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAP 660

Query: 264 -----VCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTY 318
                 C HG+C   +     C CD  ++GP CE     C+S      G C    S Y  
Sbjct: 661 PEDNCTCHHGHCQRSS-----CVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNC 715

Query: 319 ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFP 378
            CP G +      +++     PC NG  C        C C P  T   C++    C S P
Sbjct: 716 TCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAP 775

Query: 379 LRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIP 438
             N  TC      + C C  GF    CE  +         C N   C +     + +C  
Sbjct: 776 CFNGGTCVNRPGTFSCLCAMGFQGPRCEGKL-RPSCADSPCRNRATCQDSPQGPRCLCPT 834

Query: 439 GCTKNPCWFLKNVYL-----IHQHLCYCGVTFHGIC 469
           G T   C  L ++        + H    G +FH +C
Sbjct: 835 GYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLC 870



 Score =  100 bits (249), Expect = 4e-21
 Identities = 103/391 (26%), Positives = 153/391 (39%), Gaps = 51/391 (13%)

Query: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDAC-SFKPCKNNGSC---------IN 230
           E C+  G CLS +  +  +C C P F G+ CQ  D C + + C+N GSC         + 
Sbjct: 33  EPCANGGTCLSLSLGQG-TCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLP 91

Query: 231 KRENWDEQAYECVCHPPFTGKNC-SEIIGQCQPHVCF-HGNCSNITSNSFICECDEQFSG 288
              +    ++ C C P FTG+ C +++   C P  C   G C    S    C C   ++G
Sbjct: 92  SSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTG 151

Query: 289 PFCEV----SAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEF--SLVPCQ 342
             C++    SA PCV+      G+C  +       CP G      E DV+E      PC 
Sbjct: 152 EQCQLRDFCSANPCVN-----GGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCP 206

Query: 343 NGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKC-EKD---YPCSCIS 398
            GT C        C+C        C+     C      N  TC+   EKD   + C C  
Sbjct: 207 KGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPP 266

Query: 399 GFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHL 458
           GF   +CE   D+C  +S  C N   C + +  +  +C    T   C          + +
Sbjct: 267 GFIGPDCEVNPDNC--VSHQCQNGGTCQDGLDTYTCLCPETWTGWDC---------SEDV 315

Query: 459 CYCGVTFHGICQDKGPAQ-----FEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATY 513
             C       C++ G  Q     F  V   G+ G+    C+  +D    +AA C   +T 
Sbjct: 316 DECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGT---SCEENLDD--CIAATCAPGSTC 370

Query: 514 VNDPEDNNSSCWFPHEGTKEICANGCSCLSE 544
           ++     + SC  P   T  +C     CLS+
Sbjct: 371 ID--RVGSFSCLCPPGRTGLLCHLEDMCLSQ 399



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 60/213 (28%), Positives = 83/213 (38%), Gaps = 54/213 (25%)

Query: 154  SGPS---PCPLGLRLNVTVKQQFCQESLS---SEFCSGHGKCLSEAWSKTYSCHCQPPFS 207
            SGPS    CP G + ++      CQ+ ++   S  C     C+++     Y C C P + 
Sbjct: 910  SGPSYFCHCPPGFQGSL------CQDHVNPCESRPCQNGATCMAQP--SGYLCQCAPGYD 961

Query: 208  GKYC-QELDACSFKPCKNNGSCINKRENW-----------------DE------------ 237
            G+ C +ELDAC  +PC N+G+C  K   +                 DE            
Sbjct: 962  GQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTA 1021

Query: 238  ------QAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS---FICECDEQFSG 288
                   A+ C C P  TG+ C   I  C    CFHG     T+ S   FIC C + F G
Sbjct: 1022 ACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEG 1081

Query: 289  PFCEVSAKPCVSLLFWKRGIC-PNSSSAYTYEC 320
            P C   A  C        G+C P+    +   C
Sbjct: 1082 PTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRC 1114


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score =  134 bits (338), Expect = 2e-31
 Identities = 73/234 (31%), Positives = 101/234 (43%), Gaps = 7/234 (2%)

Query: 212  QELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCS 271
            Q    C F PC N+G+C         + Y C+C   +TG  C   I +C P  C +    
Sbjct: 1192 QVFHECFFNPCHNSGTCQQLG-----RGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVC 1246

Query: 272  NITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGET 331
                  FICEC   ++G  CE +   C S     +GIC +  + Y   C KG    + ET
Sbjct: 1247 KDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCET 1306

Query: 332  DVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKD 391
            +V+E    PC N   C       +C C P F    C      C S P +N ATCK     
Sbjct: 1307 EVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANS 1366

Query: 392  YPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPC 445
            + C C +GFT  +CE  I+ C+  S  C N+  C + +  +   C PG +   C
Sbjct: 1367 FRCLCAAGFTGSHCELNINECQ--SNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418



 Score =  119 bits (298), Expect = 8e-27
 Identities = 67/225 (29%), Positives = 94/225 (41%), Gaps = 8/225 (3%)

Query: 183  CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
            C   G C  +   + Y C C   ++G  C+ ++D CS  PC NNG C +         + 
Sbjct: 1202 CHNSGTC--QQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGE-----FI 1254

Query: 242  CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
            C C   +TG+ C E I +C    C +          + C C + F G  CE     C S 
Sbjct: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314

Query: 302  LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
                  +C +    +  +CP G        +V E    PC+NG  C   +N   C+C+  
Sbjct: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374

Query: 362  FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
            FT   C+     C+S P RN ATC      Y C C  GF+ K CE
Sbjct: 1375 FTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419



 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 54/216 (25%), Positives = 93/216 (43%), Gaps = 11/216 (5%)

Query: 159  CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDAC 217
            CPLG      +K +   +  S   C  +G C        + C C   ++G+ C+E ++ C
Sbjct: 1219 CPLGY---TGLKCETDIDECSPLPCLNNGVCKDLVGE--FICECPSGYTGQRCEENINEC 1273

Query: 218  SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
            S  PC N G C++         Y C C   F G +C   + +CQ + C +          
Sbjct: 1274 SSSPCLNKGICVD-----GVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGG 1328

Query: 278  FICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFS 337
            F+C+C   F G  C  +   C+S        C + ++++   C  G +  + E +++E  
Sbjct: 1329 FLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQ 1388

Query: 338  LVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTS 373
              PC+N   C+   N   C C P F+   C++ Q++
Sbjct: 1389 SNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQST 1424



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 63/259 (24%), Positives = 100/259 (38%), Gaps = 68/259 (26%)

Query: 340  PCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISG 399
            PC N   C ++    +C+C   +T L C++    C   P  NN  CK    ++ C C SG
Sbjct: 1201 PCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSG 1260

Query: 400  FTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG------------CTKNPCWF 447
            +T + CE+ I+ C   S  CLN+  C + +  ++  C+ G            C  NPC  
Sbjct: 1261 YTGQRCEENINECS--SSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPC-- 1316

Query: 448  LKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANC 507
            L N                 +C+D+              G    KC        FL   C
Sbjct: 1317 LNNA----------------VCEDQ-------------VGGFLCKCPPG-----FLGTRC 1342

Query: 508  TEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENT 567
             ++                  E   + C NG +C  ++ +  +R LC   + G+    N 
Sbjct: 1343 GKNVD----------------ECLSQPCKNGATC--KDGANSFRCLCAAGFTGSHCELNI 1384

Query: 568  TDDQENECQHEAVCKDEIN 586
             + Q N C+++A C DE+N
Sbjct: 1385 NECQSNPCRNQATCVDELN 1403



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 36/112 (32%), Positives = 52/112 (46%), Gaps = 6/112 (5%)

Query: 198  YSCHCQPPFSGKYC-QELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
            + C C P F G  C + +D C  +PCKN  +C +        ++ C+C   FTG +C   
Sbjct: 1329 FLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKD-----GANSFRCLCAAGFTGSHCELN 1383

Query: 257  IGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGI 308
            I +CQ + C +        NS+ C+C   FSG  CE       +L F   GI
Sbjct: 1384 INECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGI 1435



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 70/290 (24%), Positives = 104/290 (35%), Gaps = 58/290 (20%)

Query: 310  PNSSSAYTYECP-KGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCK 368
            PN+  A+   CP  G++   G   ++E     C + +     + +   +  P     + K
Sbjct: 1133 PNAGKAFCLACPFYGTTPFAGSRSITE-----CSSFSSTFSAAEE--SVVPPASLGHIKK 1185

Query: 369  SIQTSCESF------PLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNE 422
              + S + F      P  N+ TC++  + Y C C  G+T   CE  ID C  L   CLN 
Sbjct: 1186 RHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLP--CLNN 1243

Query: 423  EWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQ 482
              C +++G F   C  G T   C   +N+       C       GIC D G A +     
Sbjct: 1244 GVCKDLVGEFICECPSGYTGQRCE--ENINECSSSPCLN----KGICVD-GVAGYRCTCV 1296

Query: 483  LGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCL 542
             GF G   E                    T VN+ + N              C N   C 
Sbjct: 1297 KGFVGLHCE--------------------TEVNECQSNP-------------CLNNAVC- 1322

Query: 543  SEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLC 592
             E+    +   C   + G    +N  +     C++ A CKD  N  R LC
Sbjct: 1323 -EDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLC 1371



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 50/189 (26%), Positives = 72/189 (38%), Gaps = 33/189 (17%)

Query: 230  NKRENWDEQAYECV---CHPPFTGKNCSEI-----IGQCQPHVCFHGNCSNITSNSFICE 281
            N  E W + + +C    C PP   +N          G    + C+ G        S   E
Sbjct: 3399 NPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLE 3458

Query: 282  CDEQFSGPFCEVSAK-PCVSLLFWKRGIC--PNSSSAYTYECPKGSSSQNGETDVSEFSL 338
                 S P C    + PC +      GIC  PN+ S     CP+G   +  E  +    +
Sbjct: 3459 NGTWTSPPICRAVCRFPCQN-----GGICQRPNACS-----CPEGWMGRLCEEPIC---I 3505

Query: 339  VPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCIS 398
            +PC NG  C+       C C P +T   C +    C+S P  N     KC +   C C+S
Sbjct: 3506 LPCLNGGRCVA---PYQCDCPPGWTGSRCHT--AVCQS-PCLNGG---KCVRPNRCHCLS 3556

Query: 399  GFTEKNCEK 407
             +T  NC +
Sbjct: 3557 SWTGHNCSR 3565



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 15/83 (18%)

Query: 172  QFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINK 231
            + C+E +    C   G+C++      Y C C P ++G  C    A    PC N G C+  
Sbjct: 3497 RLCEEPICILPCLNGGRCVAP-----YQCDCPPGWTGSRCH--TAVCQSPCLNGGKCVRP 3549

Query: 232  RENWDEQAYECVCHPPFTGKNCS 254
                      C C   +TG NCS
Sbjct: 3550 N--------RCHCLSSWTGHNCS 3564



 Score = 37.0 bits (84), Expect = 0.051
 Identities = 19/50 (38%), Positives = 28/50 (56%), Gaps = 8/50 (16%)

Query: 211  CQELDACSF-KPCKNNGSCINKRENWDEQAYECVCHPPFT--GKNCSEII 257
            C ++D C+    C  + SC+N      + +Y C C PP+T  GKNC+E I
Sbjct: 1743 CLDVDECAVGSDCSEHASCLNV-----DGSYICSCVPPYTGDGKNCAEPI 1787



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 2/37 (5%)

Query: 183  CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSF 219
            C     C+ E    +YSC CQP FSGK C+   +  F
Sbjct: 1392 CRNQATCVDEL--NSYSCKCQPGFSGKRCETEQSTGF 1426



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 18/46 (39%), Positives = 21/46 (45%), Gaps = 4/46 (8%)

Query: 183  CSGHGKCLSEAWSKTYSCHCQPPFS--GKYCQELDACSFKPCKNNG 226
            CS H  CL+   S  Y C C PP++  GK C E   C       NG
Sbjct: 1755 CSEHASCLNVDGS--YICSCVPPYTGDGKNCAEPIKCKAPGNPENG 1798



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 25/86 (29%), Positives = 33/86 (38%), Gaps = 14/86 (16%)

Query: 340  PCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISG 399
            PCQNG  C + +    C C   +   LC+  +  C   P  N     +C   Y C C  G
Sbjct: 3475 PCQNGGICQRPN---ACSCPEGWMGRLCE--EPIC-ILPCLNGG---RCVAPYQCDCPPG 3525

Query: 400  FTEKNCEKAIDHCKLLSINCLNEEWC 425
            +T   C     H  +    CLN   C
Sbjct: 3526 WTGSRC-----HTAVCQSPCLNGGKC 3546


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  132 bits (332), Expect = 9e-31
 Identities = 117/431 (27%), Positives = 169/431 (39%), Gaps = 41/431 (9%)

Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242
           C+  G+C ++  S+  +C C P + G+ CQ  D C   PC   G C +       + + C
Sbjct: 49  CANGGRC-TQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTAR-FSC 106

Query: 243 VCHPPFTGKNCSEIIGQCQPHVCFHG-NCSNITSNSFICECDEQFSGPFCEVSAKPC-VS 300
            C   F G +CS +   C    C HG  CS      F+C C   + G  C      C V 
Sbjct: 107 RCPRGFRGPDCS-LPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG 165

Query: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVM--CIC 358
                 G C N+  ++  +CP G +    E      +  PC+NG  C + S D+   C C
Sbjct: 166 EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTC-RQSGDLTYDCAC 224

Query: 359 SPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSIN 418
            P F    C+     C      N  TC      Y C C   +T + C + +D C+L    
Sbjct: 225 LPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNA 284

Query: 419 CLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHG-ICQDKGPAQF 477
           C N   CFN +G    VC+ G T   C   +N+       C   V FHG  C D+  A F
Sbjct: 285 CHNGGTCFNTLGGHSCVCVNGWTGESC--SQNI-----DDCATAVCFHGATCHDR-VASF 336

Query: 478 EYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEIC-- 535
                +   G  G  C  + DA   ++  C EDA    +P +  + C  P   T   C  
Sbjct: 337 YCACPM---GKTGLLCH-LDDA--CVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQ 390

Query: 536 --------ANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENE-----CQHEAVCK 582
                   AN C  L    + +  +LC     G  Y     +   NE     C+++A C 
Sbjct: 391 DVDECSIGANPCEHLGRCVNTQGSFLC---QCGRGYTGPRCETDVNECLSGPCRNQATCL 447

Query: 583 DEINRPRYLCI 593
           D I +   +C+
Sbjct: 448 DRIGQFTCICM 458



 Score =  129 bits (325), Expect = 6e-30
 Identities = 111/436 (25%), Positives = 165/436 (37%), Gaps = 66/436 (15%)

Query: 197 TYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
           ++ C C    +G  C   DAC   PC  +  C     N       C C P FTG  C + 
Sbjct: 335 SFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAI---CTCPPGFTGGACDQD 391

Query: 257 IGQCQ--PHVCFH-GNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSS 313
           + +C    + C H G C N T  SF+C+C   ++GP CE     C+S     +  C +  
Sbjct: 392 VDECSIGANPCEHLGRCVN-TQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRI 450

Query: 314 SAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTS 373
             +T  C  G +    E D+ E    PC NG  C    N   C C   F+   C+     
Sbjct: 451 GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDE 510

Query: 374 CESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFK 433
           C S P RN A C      Y C C  GF    C++ +D C   S +  +   C + I  F 
Sbjct: 511 CASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDC---SPDPCHHGRCVDGIASFS 567

Query: 434 YVCIPG------------CTKNPCWF-LKNVYLIHQHLCYC--GVT-------------- 464
             C PG            C   PC    K + L+ ++LC C  G T              
Sbjct: 568 CACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN 627

Query: 465 --FHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNS 522
               G+C+D G  +++ V Q GF    G  C   ++     ++ C E  + V+   +N  
Sbjct: 628 PCTFGVCRD-GINRYDCVCQPGFT---GPLCN--VEINECASSPCGEGGSCVDG--ENGF 679

Query: 523 SCWFP------------HEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDD 570
            C  P            H    E C++G   +  +    +R +C   W+G    ++   D
Sbjct: 680 RCLCPPGSLPPLCLPPSHPCAHEPCSHG---ICYDAPGGFRCVCEPGWSGPRCSQSLARD 736

Query: 571 --QENECQHEAVCKDE 584
             +   C+    C  +
Sbjct: 737 ACESQPCRAGGTCSSD 752



 Score =  129 bits (324), Expect = 8e-30
 Identities = 116/478 (24%), Positives = 172/478 (35%), Gaps = 71/478 (14%)

Query: 171  QQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCIN 230
            Q   +++  S+ C   G C S+     + C C P   G+ C+ L  C+  PC++ G C +
Sbjct: 731  QSLARDACESQPCRAGGTCSSDGMG--FHCTCPPGVQGRQCELLSPCTPNPCEHGGRCES 788

Query: 231  K------------------RENWDEQA-----------------YECVCHPPFTGKNCSE 255
                               +++ DE A                 + C CH  +TG +C +
Sbjct: 789  APGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQ 848

Query: 256  IIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSA 315
             I  C P+ C +G        SF C C   F+GP C      C+S      G C +  ++
Sbjct: 849  DINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGP-GTCTDHVAS 907

Query: 316  YTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCE 375
            +T  CP G    + E D+ + S   C NG  C+   N   C+C P +T   C+     C 
Sbjct: 908  FTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCL 967

Query: 376  SFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYV 435
            S P  +   C      + C+C+  FT   C+  +D C      C N   C    G +  +
Sbjct: 968  SRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQP--CQNGGRCVQ-TGAY-CL 1023

Query: 436  CIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFE--YVWQLGFAGSEGEKC 493
            C PG +   C          +     GV    +CQ  G    E    + +   G  G  C
Sbjct: 1024 CPPGWSGRLCDI--RSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHC 1081

Query: 494  QGVIDAYFFLAANCTEDAT---YVND------PEDNNSSCWFP-HEGTKEICANGCSCLS 543
            +  +D    LA  C    T   Y+        P  N  +C     E   + C +G SC+ 
Sbjct: 1082 EQEVDP--CLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCI- 1138

Query: 544  EEDSQEYRYLCFL--RWAGNMYLENTTD-------DQENECQHEAVCKDEINRPRYLC 592
                   RYLC       G +   N  D       D    C H   C D +   R  C
Sbjct: 1139 ---DLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTC 1193



 Score =  120 bits (302), Expect = 3e-27
 Identities = 89/346 (25%), Positives = 143/346 (41%), Gaps = 50/346 (14%)

Query: 154  SGPSPC-PLGLRLNVT----------VKQQFCQESLSS---EFCSGHGKCLSEAWSKTYS 199
            +GP+PC P G+  N+                C + ++      C   G C     S  +S
Sbjct: 815  AGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGS--FS 872

Query: 200  CHCQPPFSGKYC-QELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIG 258
            C C P F+G  C +++D C   PC   G+C +        ++ C C P + G +C + + 
Sbjct: 873  CSCLPGFAGPRCARDVDECLSNPC-GPGTCTDH-----VASFTCTCPPGYGGFHCEQDLP 926

Query: 259  QCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTY 318
             C P  CF+G       NSF C C   ++G  C+  A PC+S      G+C  +   +  
Sbjct: 927  DCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRC 986

Query: 319  ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCE--- 375
             C +  +    +T V   S  PCQNG  C++      C+C P ++  LC      C    
Sbjct: 987  TCLESFTGPQCQTLVDWCSRQPCQNGGRCVQ--TGAYCLCPPGWSGRLCDIRSLPCREAA 1044

Query: 376  -SFPLRNNATCK---KC---EKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNI 428
                +R    C+   +C   +  + C C  G T  +CE+ +D C  L+  C +   C   
Sbjct: 1045 AQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPC--LAQPCQHGGTCRGY 1102

Query: 429  IGRFKYVCIPG------------CTKNPCWFLKN-VYLIHQHLCYC 461
            +G +   C+PG            C   PC    + + L+ ++LC C
Sbjct: 1103 MGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSC 1148



 Score =  114 bits (284), Expect = 3e-25
 Identities = 80/279 (28%), Positives = 116/279 (41%), Gaps = 27/279 (9%)

Query: 186  HGKCLSEAWSKTYSCHCQPPFSGKYCQEL-DACSFKPCKNNGSCINKRENWDEQAYECVC 244
            HG   S A    + C C   F+G  CQ L D CS +PC+N G C+         AY C+C
Sbjct: 973  HGGVCSAA-HPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTG------AY-CLC 1024

Query: 245  HPPFTGKNC----------SEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVS 294
             P ++G+ C          +  IG     +C  G       +S  C C E  +G  CE  
Sbjct: 1025 PPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQE 1084

Query: 295  AKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDV 354
              PC++      G C      Y  EC  G +  N E DV E +  PCQ+G  CI +    
Sbjct: 1085 VDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARY 1144

Query: 355  MCICSPIFTDLLCKSIQTSCESFP-------LRNNATCKKCEKDYPCSCISGFTEKNCEK 407
            +C C P    +LC+  +  C   P         +N TC      + C+C  G+T   CE 
Sbjct: 1145 LCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEA 1204

Query: 408  AIDHCKLLSINCLNEEWCF-NIIGRFKYVCIPGCTKNPC 445
             I+ C+  + +  +   C  +  G F+ +C  G +   C
Sbjct: 1205 DINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRC 1243



 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 54/242 (22%), Positives = 86/242 (35%), Gaps = 62/242 (25%)

Query: 183  CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCK--NNGSCINKRENWDEQA 239
            C  +G C+       + C C P ++G  C+ +++ C    C   +   C+          
Sbjct: 1176 CLHNGTCVDLVGG--FRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGG----G 1229

Query: 240  YECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSN-----SFICECDEQFSGPFCEVS 294
            + C+CH  F+G  C  ++  C+   C HG     +       +F C C + F GP CE  
Sbjct: 1230 FRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERV 1289

Query: 295  AKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDV 354
            A+ C  L                 +CP G               VPCQ      +     
Sbjct: 1290 ARSCREL-----------------QCPVG---------------VPCQ------QTPRGP 1311

Query: 355  MCICSPIFTDLLCKSI--------QTSCESFPLRNNATCKKC--EKDYPCSCISGFTEKN 404
             C C P  +   C+S           SC + P  +  +C+       + C+C  G+T   
Sbjct: 1312 RCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPR 1371

Query: 405  CE 406
            CE
Sbjct: 1372 CE 1373


>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
          Length = 1406

 Score =  128 bits (322), Expect = 1e-29
 Identities = 106/432 (24%), Positives = 167/432 (38%), Gaps = 40/432 (9%)

Query: 161 LGLRLNVTVKQQFCQESLS---SEFCSGHGKCLSEAWSKTYSCHCQPPFSG--KYCQEL- 214
           L   L + +K  FC ++ +   S  C  +  C  + +SK   C C    +   K C  + 
Sbjct: 14  LSFSLLIYIKNSFCNKNNTRCLSNSCQNNSTC--KDFSKDNDCSCSDTANNLDKDCDNMK 71

Query: 215 DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNIT 274
           D C   PC+ + +C+N      E+++ C C P ++G  C   IG C  + C HG   +  
Sbjct: 72  DPCFSNPCQGSATCVNTP---GERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQD 128

Query: 275 SNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVS 334
               +C C   ++G FCE+    C S       +C +    Y+  C  G   ++ + +V 
Sbjct: 129 PIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVD 188

Query: 335 EFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPC 394
           E +  PC+N   C+       CIC   ++ + C+     C S P  N ATC+     Y C
Sbjct: 189 ECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFC 248

Query: 395 SCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCI-PGCTKNPCWFLKNVYL 453
            C  GF   +CE   D C   S  CL+   C +   R+   C   G T   C  L  + L
Sbjct: 249 DCAPGFLGDHCELNTDEC--ASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETL--MPL 304

Query: 454 IHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATY 513
                C+   T    C+D       + W  G+ G                 A C  D   
Sbjct: 305 CWSKPCHNNAT----CEDSVDNYTCHCWP-GYTG-----------------AQCEIDLNE 342

Query: 514 VN-DPEDNNSSCWFPHEGTKEICANGC-SCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQ 571
            N +P  +N  C       +     G  S  S  ++  Y  +C   + G    E+  +  
Sbjct: 343 CNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECS 402

Query: 572 ENECQHEAVCKD 583
            N CQ+   C++
Sbjct: 403 SNPCQNGGTCEN 414



 Score =  119 bits (299), Expect = 6e-27
 Identities = 94/390 (24%), Positives = 141/390 (36%), Gaps = 87/390 (22%)

Query: 174 CQESLSSEFCS-GHGKCLSEAWSKT---------YSCHCQPPFSGKYCQ-ELDACSFKPC 222
           C    +  FC   H +C S               YSC C P + G++C  E+D C+  PC
Sbjct: 136 CPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPC 195

Query: 223 KNNGSCINK---------------------RENWDEQ------------AYECVCHPPFT 249
           KN  +C+N+                      E W +             AY C C P F 
Sbjct: 196 KNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFL 255

Query: 250 GKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQ-FSGPFCEVSAKPCVSLLFWKRGI 308
           G +C     +C    C HG       N + C C    F+G  CE     C S        
Sbjct: 256 GDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNAT 315

Query: 309 CPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND--------------- 353
           C +S   YT  C  G +    E D++E +  PCQ+  +C+++S++               
Sbjct: 316 CEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSY 375

Query: 354 -----VMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKA 408
                 +CIC P FT + C+     C S P +N  TC+    +Y C C      +     
Sbjct: 376 HEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGG 435

Query: 409 IDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHG- 467
            D C  + + C +++ C N        CIP                H   C C   + G 
Sbjct: 436 RD-CSDILLGCTHQQ-CLN-----NGTCIPHFQDGQ----------HGFSCLCPSGYTGS 478

Query: 468 ICQDKGPAQFE---YVW-QLGFAGSEGEKC 493
           +C+      FE   ++W + G   ++G  C
Sbjct: 479 LCEIATTLSFEGDGFLWVKSGSVTTKGSVC 508



 Score =  104 bits (260), Expect = 2e-22
 Identities = 65/229 (28%), Positives = 91/229 (39%), Gaps = 40/229 (17%)

Query: 179  SSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDE 237
            +S  C   G C  E    +Y C C   +SGK+C+  +D C   PC + G+C ++      
Sbjct: 1144 NSNPCLHGGNC--EDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSDR-----V 1195

Query: 238  QAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKP 297
             AY C C P +TG NC   I  CQ H C +G      +N + C C   F+G FC  S  P
Sbjct: 1196 AAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLP 1255

Query: 298  CVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCI 357
                      +C N  +  T                       C NG +C +   ++ C+
Sbjct: 1256 ST--------VCGNEKTNLT-----------------------CYNGGNCTEFQTELKCM 1284

Query: 358  CSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
            C P FT   C+     C S P  N   C+     + C C   F  + CE
Sbjct: 1285 CRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCE 1333



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 58/190 (30%), Positives = 86/190 (45%), Gaps = 22/190 (11%)

Query: 260  CQPHVCFH-GNCSNITSNSFICECDEQFSGPFCEVS-----AKPCVSLLFWKRGICPNSS 313
            C  + C H GNC +I S S+ C C   +SG  CE++     + PC+       G C +  
Sbjct: 1143 CNSNPCLHGGNCEDIYS-SYHCSCPLGWSGKHCELNIDECFSNPCI------HGNCSDRV 1195

Query: 314  SAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQ-- 371
            +AY   C  G +  N E D+       C NG  CI  +N   C+C   FT   C+  +  
Sbjct: 1196 AAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLP 1255

Query: 372  -TSC----ESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCF 426
             T C     +    N   C + + +  C C  GFT + CEK ID C   S  C+N   C 
Sbjct: 1256 STVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDEC--ASDPCVNGGLCQ 1313

Query: 427  NIIGRFKYVC 436
            +++ +F+ +C
Sbjct: 1314 DLLNKFQCLC 1323



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 54/193 (27%), Positives = 83/193 (43%), Gaps = 16/193 (8%)

Query: 307  GICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLL 366
            G C +  S+Y   CP G S ++ E ++ E    PC +G +C        C C P +T + 
Sbjct: 1152 GNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHG-NCSDRVAAYHCTCEPGYTGVN 1210

Query: 367  CKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKA-----IDHCKLLSINCLN 421
            C+    +C+S    N ATC      Y C C   FT K C ++     +   +  ++ C N
Sbjct: 1211 CEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYN 1270

Query: 422  EEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVW 481
               C       K +C PG T    W  K++       C  G    G+CQD    +F+ + 
Sbjct: 1271 GGNCTEFQTELKCMCRPGFTGE--WCEKDIDECASDPCVNG----GLCQDL-LNKFQCLC 1323

Query: 482  QLGFAGSEGEKCQ 494
             + FA   GE+C+
Sbjct: 1324 DVAFA---GERCE 1333



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 74/299 (24%), Positives = 121/299 (40%), Gaps = 55/299 (18%)

Query: 59   FLGVNTKIDTSGNQAVPQICPLQ-----IQLGDILVISSEPSLQF----PEINLMNVSET 109
            FL  NT I   G++A+  I  LQ     I++G I +   E    F     E   + +S  
Sbjct: 1073 FLKDNTDIYV-GDRAIDNIKGLQGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTN 1131

Query: 110  SFV-GCVQ-NTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNV 167
            S V GC+Q N    +  L G   + +++                  S    CPLG     
Sbjct: 1132 SVVTGCLQLNVCNSNPCLHGGNCEDIYS------------------SYHCSCPLGW---- 1169

Query: 168  TVKQQFCQESLSSEFCSG--HGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKN 224
                + C+ ++   F +   HG C        Y C C+P ++G  C+ ++D C    C N
Sbjct: 1170 --SGKHCELNIDECFSNPCIHGNCSDRV--AAYHCTCEPGYTGVNCEVDIDNCQSHQCAN 1225

Query: 225  NGSCINKRENWDEQAYECVCHPPFTGKNC------SEIIGQCQPHV-CFHG-NCSNITSN 276
              +CI+         Y C+C   FTGK C      S + G  + ++ C++G NC+   + 
Sbjct: 1226 GATCISHTNG-----YSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTE 1280

Query: 277  SFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSE 335
               C C   F+G +CE     C S      G+C +  + +   C    + +  E D+++
Sbjct: 1281 -LKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDLAD 1338



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 47/174 (27%), Positives = 67/174 (38%), Gaps = 40/174 (22%)

Query: 81  QIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTTEDQLLFGCRLKGMHTVNSKW 140
           +I+ GD++ I   P  Q  E+N        F GC+Q+    +Q L               
Sbjct: 823 KIEKGDVIYIGGLPDKQETELN-----GGFFKGCIQDVRLNNQNL--------------- 862

Query: 141 LSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFC--QESLSSEFCSGHGKCLSEAWSKTY 198
                  F     +  S  P+   +NVT   Q C    S  S  C   G C S  W   +
Sbjct: 863 ------EFFPNPTNNASLNPV--LVNVT---QGCAGDNSCKSNPCHNGGVCHSR-WDD-F 909

Query: 199 SCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKN 252
           SC C    SGK C+E+  C F PC +   C         Q +EC+ +  F G++
Sbjct: 910 SCSCPALTSGKACEEVQWCGFSPCPHGAQCQPVL-----QGFECIANAVFNGQS 958



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 50/219 (22%), Positives = 81/219 (36%), Gaps = 38/219 (17%)

Query: 374  CESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFK 433
            C S P  +   C+     Y CSC  G++ K+CE  ID C   S  C++   C + +  + 
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDEC--FSNPCIHGN-CSDRVAAYH 1199

Query: 434  YVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKC 493
              C PG T   C    ++     H C  G T   I    G +       L F    G+ C
Sbjct: 1200 CTCEPGYTGVNCEV--DIDNCQSHQCANGATC--ISHTNGYS------CLCFGNFTGKFC 1249

Query: 494  QGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYL 553
            +                       +    S    +E T   C NG +C   E   E + +
Sbjct: 1250 R-----------------------QSRLPSTVCGNEKTNLTCYNGGNC--TEFQTELKCM 1284

Query: 554  CFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLC 592
            C   + G    ++  +   + C +  +C+D +N+ + LC
Sbjct: 1285 CRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLC 1323



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 5/43 (11%)

Query: 211 CQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNC 253
           C   D C  +PC++ G CIN    W   +Y+C CH P+ G NC
Sbjct: 670 CVRKDWCESQPCQSRGRCINL---W--LSYQCDCHRPYEGPNC 707



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 23/78 (29%), Positives = 31/78 (39%), Gaps = 6/78 (7%)

Query: 211 CQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNC 270
           C   ++C   PC N G C      WD+  + C C    +GK C E +  C    C HG  
Sbjct: 885 CAGDNSCKSNPCHNGGVC---HSRWDD--FSCSCPALTSGKACEE-VQWCGFSPCPHGAQ 938

Query: 271 SNITSNSFICECDEQFSG 288
                  F C  +  F+G
Sbjct: 939 CQPVLQGFECIANAVFNG 956



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 15/55 (27%), Positives = 24/55 (43%), Gaps = 1/55 (1%)

Query: 340 PCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPC 394
           PC NG  C    +D  C C  + +   C+ +Q  C   P  + A C+   + + C
Sbjct: 895 PCHNGGVCHSRWDDFSCSCPALTSGKACEEVQW-CGFSPCPHGAQCQPVLQGFEC 948



 Score = 30.8 bits (68), Expect = 3.7
 Identities = 30/120 (25%), Positives = 48/120 (40%), Gaps = 16/120 (13%)

Query: 486 AGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFP--HEGT----------KE 533
           A +  + C  + D  F  +  C   AT VN P + +  C  P  + GT          K 
Sbjct: 60  ANNLDKDCDNMKDPCF--SNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKN 117

Query: 534 ICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLCI 593
            C +G  C   +D      +C   +AG     +  +   + CQ+ AVC+D I+     C+
Sbjct: 118 SCQHGGIC--HQDPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCV 175



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 13/35 (37%), Positives = 18/35 (51%)

Query: 373 SCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEK 407
           SC+S P  N   C     D+ CSC +  + K CE+
Sbjct: 890 SCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEE 924


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score =  127 bits (320), Expect = 2e-29
 Identities = 105/415 (25%), Positives = 148/415 (35%), Gaps = 65/415 (15%)

Query: 175 QESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRE 233
           ++  +S  C   G C  E  +  + CHC   FSG  C+ ++D C   PC+N   C N   
Sbjct: 499 RDECASSPCHSGGLC--EDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNL-- 554

Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCF------------------------HGN 269
              E  Y C C   F GKNCS     C    C                         HG 
Sbjct: 555 ---EGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGR 611

Query: 270 CSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNG 329
           C +    +F C CD  F+G +C  +   C+       G C +   A+   CP G   +  
Sbjct: 612 CVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 671

Query: 330 ETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCE 389
           +T+ ++    PC +   C  + ND  C C   +    C S +  C+++   N  TC    
Sbjct: 672 DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSG 731

Query: 390 KDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLK 449
             + C+C  G+    C  A  +   L   C+N   C      F  +C  G     C    
Sbjct: 732 DTFRCACPPGWKGSTCAVA-KNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTC--TH 788

Query: 450 NVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEG----EKCQGVIDAYFFLAA 505
           N    +   CY G    GIC D G   F      GFAG +     ++CQ    AY    A
Sbjct: 789 NTNDCNPLPCYNG----GICVD-GVNWFRCECAPGFAGPDCRINIDECQSSPCAY---GA 840

Query: 506 NCTED-------------ATYVNDPEDNNSSCW-----FPHEGTKEICANGCSCL 542
            C ++                  +      SCW     FPH  +     N C CL
Sbjct: 841 TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCL 895



 Score =  124 bits (312), Expect = 2e-28
 Identities = 125/491 (25%), Positives = 169/491 (34%), Gaps = 98/491 (19%)

Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA--CSFKPCKNNGSCINKRE 233
           +  +S  C+  G C+ +     + C C   + G  CQ LDA  C  KPC N  SC N   
Sbjct: 387 DECASNPCAAGGTCVDQV--DGFECICPEQWVGATCQ-LDANECEGKPCLNAFSCKNLIG 443

Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEV 293
                 Y C C P + G NC   +  C+   C HG       N + C C   F G  CE+
Sbjct: 444 G-----YYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCEL 497

Query: 294 SAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND 353
               C S      G+C + +  +   CP+G S    E DV      PC+NG  C  +  D
Sbjct: 498 ERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGD 557

Query: 354 VMCICSPIFTDLLCKSIQTSCESFPLRNNATCK--------------------KCEK--- 390
             C C   F    C   +  C     R    C                     +C     
Sbjct: 558 YYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPG 617

Query: 391 -DYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG---------- 439
            ++ C C SGFT   C + ID C  L   C N   C + +  F+  C  G          
Sbjct: 618 GNFSCICDSGFTGTYCHENIDDC--LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNP 675

Query: 440 --CTKNPCWFLKNVY-LIHQHLCYC-----GVTFH--------------GICQDKGPAQF 477
             C  +PC      Y L++   C C     G T H              G C D G   F
Sbjct: 676 NDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT-F 734

Query: 478 EYVWQLGFAGS----------------EGEKCQGVIDAYFFLAANCTEDATYVNDPEDNN 521
                 G+ GS                 G  C G   ++  +  +  E  T  ++  D N
Sbjct: 735 RCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCN 794

Query: 522 SSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVC 581
                P       C NG  C+  +    +R  C   +AG     N  + Q + C + A C
Sbjct: 795 P---LP-------CYNGGICV--DGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATC 842

Query: 582 KDEINRPRYLC 592
            DEIN  R  C
Sbjct: 843 VDEINGYRCSC 853



 Score =  120 bits (301), Expect = 4e-27
 Identities = 104/450 (23%), Positives = 167/450 (37%), Gaps = 58/450 (12%)

Query: 174 CQESLSSEFCSG-HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
           C+E++  + C+  HG C          C C   + G++C E   C   P   +GSC+   
Sbjct: 240 CKEAVCKQGCNLLHGGCTVPG-----ECRCSYGWQGRFCDE---CVPYPGCVHGSCV--- 288

Query: 233 ENWDEQAYECVCHPPFTGKNCSEIIGQC-QPHVCFHGN-CSNITSNSFICECDEQFSGPF 290
                + ++C C   + G  C + +  C   H C +G  C N   + + C C + +SG  
Sbjct: 289 -----EPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN 343

Query: 291 CEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKI 350
           CE +   C S      G C    S +   CP G S      D+ E +  PC  G  C+  
Sbjct: 344 CEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQ 403

Query: 351 SNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAID 410
            +   CIC   +    C+     CE  P  N  +CK     Y C CI G+   NC   ++
Sbjct: 404 VDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVN 463

Query: 411 HCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQ 470
            C+     C +   C +++  ++ VC  G     C   ++        C+ G    G+C+
Sbjct: 464 DCR---GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDE--CASSPCHSG----GLCE 514

Query: 471 DKGPAQFEYVWQLGFAG---------------SEGEKCQGVIDAYF------FLAANCT- 508
           D     F      GF+G                 G +C  +   Y+      F   NC+ 
Sbjct: 515 DLADG-FHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSV 573

Query: 509 ------EDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNM 562
                   A  V D   +++    P      +C     C+S+     +  +C   + G  
Sbjct: 574 PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG-NFSCICDSGFTGTY 632

Query: 563 YLENTTDDQENECQHEAVCKDEINRPRYLC 592
             EN  D     C++   C DE++  R  C
Sbjct: 633 CHENIDDCLGQPCRNGGTCIDEVDAFRCFC 662


>gi|122937283 6720455I24Rik homolog [Homo sapiens]
          Length = 1413

 Score =  121 bits (303), Expect = 2e-27
 Identities = 98/367 (26%), Positives = 143/367 (38%), Gaps = 52/367 (14%)

Query: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
           + +PC N G CI+     +  +Y C C   FTG+ C   + +C    C +G       NS
Sbjct: 274 ALRPCLNGGKCIDDCVTGNP-SYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINS 332

Query: 278 FICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFS 337
           F C+C   F GP CE +  PC +      G C   + +    C  G +    E DV + S
Sbjct: 333 FRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCS 392

Query: 338 LVPCQNGTDCIKISNDVMCICSPIFTDLLCKS----IQTSCESFPLRNNATCKKCEKDYP 393
             PC NG  C+ +  +  C+C+  F  L C++    +  +C S P  N  TC   ++ Y 
Sbjct: 393 PDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYV 452

Query: 394 CSCISGFTEKNC-EKAIDHCKLLS-INCL--NEEWCFNIIGRFKYVCIPGCTKNPCWFLK 449
           C C  GF   +C E+  D C+  +   CL  N   C   +G F  +C    T  PC    
Sbjct: 453 CECPEGFMGLDCRERVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPC---- 508

Query: 450 NVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTE 509
                           +  C D G     Y  + G  GS    C    +A   L + C  
Sbjct: 509 --------------NMNTQCPDGG-----YCMEHG--GSYLCVCHTDHNASHSLPSPCDS 547

Query: 510 DATYVN---DPEDNNSSCWF-------------PHEGTKEICANGCSCLSEEDSQEYRYL 553
           D  +     D  D++ +C               PH  +   C NG +C  +E   EY   
Sbjct: 548 DPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTC--KEAGGEYHCS 605

Query: 554 CFLRWAG 560
           C  R+ G
Sbjct: 606 CPYRFTG 612



 Score =  119 bits (297), Expect = 1e-26
 Identities = 96/337 (28%), Positives = 140/337 (41%), Gaps = 42/337 (12%)

Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-----LDACSFKPCKNNGSCIN 230
           +  S + C   G C+    +  Y+C C  PF G  C+       DAC   PC N G+C++
Sbjct: 389 DDCSPDPCLNGGSCVDLVGN--YTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVD 446

Query: 231 KRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSN----ITSNSFICECDEQF 286
                 +Q Y C C   F G +C E +    P  C    C N    + +N+ +C+C   F
Sbjct: 447 A-----DQGYVCECPEGFMGLDCRERV----PDDC---ECRNGGRCLGANTTLCQCPLGF 494

Query: 287 SGPFCE--VSAKPC-VSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQN 343
            G  CE  ++A PC ++      G C     +Y   C    ++ +      +    PC N
Sbjct: 495 FGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSD--PCFN 552

Query: 344 GTDCIKISNDVMCICSPIFTDLLCKSIQTS-CESFPLRNNATCKKCEKDYPCSCISGFTE 402
           G  C    +   C C   F    C+  +   C S P RN  TCK+   +Y CSC   FT 
Sbjct: 553 GGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTG 612

Query: 403 KNCE-KAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYC 461
           ++CE    D C   S  C N   CF+ IG++K  C PG +   C    +     +  C  
Sbjct: 613 RHCEIGKPDSC--ASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSP--CFRSPCVN 668

Query: 462 GVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVID 498
           G    G C+D+    F +      AG  G +CQ  +D
Sbjct: 669 G----GTCEDRDTDFFCHCQ----AGYMGRRCQAEVD 697



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 70/288 (24%), Positives = 104/288 (36%), Gaps = 56/288 (19%)

Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFK-PCKNNGSCINKREN 234
           +S +S  C   G C    +   Y C C P FSG++C+   +  F+ PC N G+C ++  +
Sbjct: 621 DSCASGPCHNGGTCFH--YIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTD 678

Query: 235 WD---EQAY-------ECVCHPP---------FTGKNCSEI----------------IGQ 259
           +    +  Y       E  C PP         F G     +                I  
Sbjct: 679 FFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRV 738

Query: 260 CQPH------------------VCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
           CQPH                   C HG         ++C C   + G  CE+    C + 
Sbjct: 739 CQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAH 798

Query: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
                G C N   AY   CP G    + ET+V      PCQ+G  C       +C+C   
Sbjct: 799 PCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPES 858

Query: 362 FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAI 409
           F    C+++   C S P      C      + C+C  G+T ++C K +
Sbjct: 859 FFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKEL 906



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 34/120 (28%), Positives = 49/120 (40%), Gaps = 8/120 (6%)

Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
           C   G C +   +  Y C C   F G +C+ E+DAC   PC++ G C +        AY 
Sbjct: 800 CRNGGSCRNLPGA--YVCRCPAGFVGVHCETEVDACDSSPCQHGGRCES-----GGGAYL 852

Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
           CVC   F G +C  +   C    C        ++ S  C C   ++G  C     P  +L
Sbjct: 853 CVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFPPTAL 912



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 18/75 (24%), Positives = 32/75 (42%), Gaps = 11/75 (14%)

Query: 246  PPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVS----AKPCVSL 301
            P    K+   + G C  + C +G      +++  C+C   F G  CE++    ++PC  L
Sbjct: 1297 PEHGSKDIGNVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRL 1356

Query: 302  L-------FWKRGIC 309
                     W+ G+C
Sbjct: 1357 FSETKAFPVWEGGVC 1371



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 14/37 (37%), Positives = 20/37 (54%), Gaps = 5/37 (13%)

Query: 217  CSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNC 253
            CS  PC+N G+C+   +     A+ C C P F G+ C
Sbjct: 1311 CSENPCQNGGTCVPGAD-----AHSCDCGPGFKGRRC 1342



 Score = 33.1 bits (74), Expect = 0.74
 Identities = 23/94 (24%), Positives = 35/94 (37%), Gaps = 14/94 (14%)

Query: 369  SIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLN-EEWCFN 427
            ++  +C   P +N  TC      + C C  GF  + CE A          C+     C  
Sbjct: 1306 NVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELA----------CIKVSRPCTR 1355

Query: 428  IIGRFKYVCIPGCTKNPCWFL-KNVYLIHQHLCY 460
            +    K    P      C  + K VY +HQ +C+
Sbjct: 1356 LFSETK--AFPVWEGGVCHHVYKRVYRVHQDICF 1387



 Score = 30.0 bits (66), Expect = 6.3
 Identities = 16/57 (28%), Positives = 24/57 (42%), Gaps = 11/57 (19%)

Query: 340  PCQNGTDCIKISNDVMCICSPIF----TDLLCKSIQTSC-------ESFPLRNNATC 385
            PCQNG  C+  ++   C C P F     +L C  +   C       ++FP+     C
Sbjct: 1315 PCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGVC 1371


>gi|112420992 crumbs homolog 2 [Homo sapiens]
          Length = 1285

 Score =  112 bits (279), Expect = 1e-24
 Identities = 92/394 (23%), Positives = 137/394 (34%), Gaps = 81/394 (20%)

Query: 153 ASGPSPCPLGLRLNVTVKQQFCQESLSSEFCSG----HGK-CLSEAWSKT-YSCHCQPPF 206
           A    PC  G     T    +    +    C+     HG  C+ +    T + C+C P F
Sbjct: 41  ACASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGF 100

Query: 207 SGKYCQ-ELDACSFKPCKNNGSCINKRENW-----------------DEQA--------- 239
            G  C+ ++D C+ +PC +  +C N  + +                 DE A         
Sbjct: 101 QGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGS 160

Query: 240 -------YECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICEC-DEQFSGPFC 291
                  + CVC P + G  C   + +CQ   C HG   +   N F C+C    + G  C
Sbjct: 161 CLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHC 220

Query: 292 EVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKIS 351
           E     C S        C     ++   C  G S +  E D  E +  PCQ+G  C++ S
Sbjct: 221 EREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRS 280

Query: 352 NDV---------------------MCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEK 390
           +                       +C C P F    C      C S P  N   C+    
Sbjct: 281 DPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPN 340

Query: 391 DYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNII------------GRFKYVCIP 438
            + C C  G+    CE+ +D C  LS  CL+   C + +            GR   V + 
Sbjct: 341 GFQCHCPDGYAGPTCEEDVDEC--LSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLT 398

Query: 439 GCTKNPCWFLKNVYLI-----HQHLCYCGVTFHG 467
           GC  + C        I     H ++C+C    HG
Sbjct: 399 GCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHG 432



 Score = 95.9 bits (237), Expect = 9e-20
 Identities = 92/402 (22%), Positives = 134/402 (33%), Gaps = 85/402 (21%)

Query: 216 ACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNC---SN 272
           AC+  PC     C    +  +   Y C    P   + C+      QP  C HG       
Sbjct: 41  ACASDPCAPGTEC----QATESGGYTC---GPMEPRGCAT-----QP--CHHGALCVPQG 86

Query: 273 ITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETD 332
                F C C   F GP CE+    C S        C N +  Y   CP G +    E +
Sbjct: 87  PDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEME 146

Query: 333 VSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDY 392
           V E +  PC +G  C+       C+C+P +    C+     C+S P  +  TC      +
Sbjct: 147 VDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGF 206

Query: 393 PCSCI-SGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG------------ 439
            C C  +G+   +CE+ +  C   S  C +   C   +G F+ +C PG            
Sbjct: 207 RCDCAGTGYEGTHCEREVLEC--ASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDE 264

Query: 440 CTKNPCWFLKNVYLIHQHLCYC----GVTFHGICQDKGPAQFEYVWQLGF-----AGSEG 490
           C  +PC          QH   C        +G  Q   P  F +    GF      G EG
Sbjct: 265 CASSPC----------QHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEG 314

Query: 491 EKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEY 550
             C   +D                              E     C NG  C  ++    +
Sbjct: 315 ADCGVEVD------------------------------ECASRPCLNGGHC--QDLPNGF 342

Query: 551 RYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLC 592
           +  C   +AG    E+  +   + C H   C D +    Y+C
Sbjct: 343 QCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTV--AGYIC 382



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 44/161 (27%), Positives = 64/161 (39%), Gaps = 8/161 (4%)

Query: 211  CQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNC 270
            C+    C+  PC ++G+C   R+ +D  A+ C C P + G  C   +  C    C  G C
Sbjct: 1054 CRGAPVCAPSPCLHDGAC---RDLFD--AFACACGPGWEGPRCEAHVDPCHSAPCARGRC 1108

Query: 271  SNITSNSFICECDEQFSGPFCE--VSAKPC-VSLLFWKRGICPNSSSAYTYECPKGSSSQ 327
                   F C C   F GP C   V +K C +++       C   S A    C +G + Q
Sbjct: 1109 HTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQ 1168

Query: 328  NGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCK 368
              +         PC NG  C        CIC+  F+   C+
Sbjct: 1169 RCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 35/121 (28%), Positives = 53/121 (43%), Gaps = 12/121 (9%)

Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKREN 234
           +  +S  C   G C  +     + CHC   ++G  C+E +D C   PC + G+C +    
Sbjct: 322 DECASRPCLNGGHC--QDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDT--- 376

Query: 235 WDEQAYECVCHPPFTGKNCSEIIGQCQPHVC-FHGNCSNITSN---SFICECDEQFSGPF 290
                Y C C   + G++CS  +  CQ H C     C  I  +   S++C C     GPF
Sbjct: 377 --VAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPF 434

Query: 291 C 291
           C
Sbjct: 435 C 435



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 29/98 (29%), Positives = 41/98 (41%), Gaps = 3/98 (3%)

Query: 198  YSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRE-NWDEQAYECVCHPPFTGKNCSEI 256
            + C C P F G  C+ L   S K C  N +C++         A  C C     G+ C   
Sbjct: 1116 FECRCPPGFGGPRCR-LPVPS-KECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVP 1173

Query: 257  IGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVS 294
               C+ + C +G           C C+ +FSG FCEV+
Sbjct: 1174 TLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEVA 1211



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 23/80 (28%), Positives = 34/80 (42%), Gaps = 7/80 (8%)

Query: 211 CQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNC 270
           C   D CS  PC N G+C+     W++  + C C   FTG  C++ +  C    C     
Sbjct: 805 CVSEDMCSPDPCFNGGTCL---VTWND--FHCTCPANFTGPTCAQQL-WCPGQPCLPPAT 858

Query: 271 SNITSNSFICECDEQF-SGP 289
                + F+C  +  F  GP
Sbjct: 859 CEEVPDGFVCVAEATFREGP 878



 Score = 37.7 bits (86), Expect = 0.030
 Identities = 14/32 (43%), Positives = 17/32 (53%)

Query: 260 CQPHVCFHGNCSNITSNSFICECDEQFSGPFC 291
           C P  CF+G    +T N F C C   F+GP C
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTC 842



 Score = 37.7 bits (86), Expect = 0.030
 Identities = 21/63 (33%), Positives = 26/63 (41%), Gaps = 1/63 (1%)

Query: 340 PCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISG 399
           PC NG  C+   ND  C C   FT   C   Q  C   P    ATC++    + C   + 
Sbjct: 815 PCFNGGTCLVTWNDFHCTCPANFTGPTCAQ-QLWCPGQPCLPPATCEEVPDGFVCVAEAT 873

Query: 400 FTE 402
           F E
Sbjct: 874 FRE 876



 Score = 32.7 bits (73), Expect = 0.97
 Identities = 18/66 (27%), Positives = 27/66 (40%), Gaps = 2/66 (3%)

Query: 374  CESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFK 433
            C   P  ++  C+     + C+C  G+    CE  +D C   S  C       +  GRF+
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCH--SAPCARGRCHTHPDGRFE 1117

Query: 434  YVCIPG 439
              C PG
Sbjct: 1118 CRCPPG 1123



 Score = 30.8 bits (68), Expect = 3.7
 Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 5/47 (10%)

Query: 211 CQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEII 257
           C+  + C   PC + GSC+   + W    + C C  P  G  C++ I
Sbjct: 603 CERREQCRPLPCVHGGSCV---DLWTH--FRCDCARPHRGPTCADEI 644



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 30/119 (25%), Positives = 44/119 (36%), Gaps = 23/119 (19%)

Query: 111 FVGCVQNTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVK 170
           F GC+Q     D  L GC L                +F   + +   P  LG R +  + 
Sbjct: 763 FRGCLQ-----DLRLDGCHLP---------------FFPLPLDNSSQPSELGGRQSWNLT 802

Query: 171 QQFCQESLSS-EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSC 228
                E + S + C   G CL   W+  + C C   F+G  C +   C  +PC    +C
Sbjct: 803 AGCVSEDMCSPDPCFNGGTCLV-TWND-FHCTCPANFTGPTCAQQLWCPGQPCLPPATC 859



 Score = 29.6 bits (65), Expect = 8.2
 Identities = 18/63 (28%), Positives = 24/63 (38%), Gaps = 4/63 (6%)

Query: 259 QCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTY 318
           QC+P  C HG         F C+C     GP C       +    +  G  P+S+S    
Sbjct: 608 QCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADE----IPAATFGLGGAPSSASFLLQ 663

Query: 319 ECP 321
           E P
Sbjct: 664 ELP 666


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score =  108 bits (269), Expect = 2e-23
 Identities = 71/275 (25%), Positives = 117/275 (42%), Gaps = 23/275 (8%)

Query: 159  CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDAC 217
            C   + +N+  K   C   LS+  C   G C S+     Y C C   F G+ C   + AC
Sbjct: 907  CQGPVDVNILAK---CNPCLSNP-CKNDGTCNSDPVD-FYRCTCPYGFKGQDCDVPIHAC 961

Query: 218  SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
               PCK+ G+C  K    +E  + C+C   F G+NC   +  C+ + C + +      N+
Sbjct: 962  ISNPCKHGGTCHLKEG--EEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINN 1019

Query: 278  FICECDEQFSGPFCEVSAKPCVSLL--FWKRGICPNSSSAYTYECPKGSSSQNGETDVSE 335
            + C C  +++G  CE     C   L        C  +   +  +C  G   ++ + D  +
Sbjct: 1020 YTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDD 1079

Query: 336  FSLVPCQNGTDCIKISNDVMCICSPIFTDLLCK-------SIQTSCESFPLRNNATCKKC 388
                 C+NG  C    N   CIC   ++ L C+          + C++F  +N A C   
Sbjct: 1080 CQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVR 1139

Query: 389  EKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEE 423
              +  C C+ G+  + CE      KL+S+N +N+E
Sbjct: 1140 INEPICQCLPGYQGEKCE------KLVSVNFINKE 1168



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 42/153 (27%), Positives = 61/153 (39%), Gaps = 4/153 (2%)

Query: 297  PCVSLLFWKRGICPNSS-SAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDC-IKISND- 353
            PC+S      G C +     Y   CP G   Q+ +  +      PC++G  C +K   + 
Sbjct: 921  PCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEED 980

Query: 354  -VMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHC 412
               CIC+  F    C+     CE     NN+TC     +Y C C   +T + CE+ +D C
Sbjct: 981  GFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFC 1040

Query: 413  KLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPC 445
                  C ++  C      FK  C PG     C
Sbjct: 1041 AQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHC 1073



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 37/157 (23%), Positives = 60/157 (38%), Gaps = 12/157 (7%)

Query: 260  CQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAK-PCVSLLFWKRGICPNSSSAYTY 318
            C   VC HG C   +   F CEC E + GP C+     PC+          P ++ +Y+ 
Sbjct: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1395

Query: 319  ECPKGSSSQNGETDVSEFS---LVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCE 375
            +C +G      + +   F+    + C++G   +       C CS  +T   C   + SC 
Sbjct: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDR-EISCR 1454

Query: 376  SFPLRN-------NATCKKCEKDYPCSCISGFTEKNC 405
               +R+        A C+  +K     C  G     C
Sbjct: 1455 GERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 58/247 (23%), Positives = 89/247 (36%), Gaps = 68/247 (27%)

Query: 360  PIFTDLLCKSIQTSCESFPLRNNATCKKCEKD-YPCSCISGFTEKNCEKAIDHCKLLSIN 418
            P+  ++L K     C S P +N+ TC     D Y C+C  GF  ++C+            
Sbjct: 910  PVDVNILAKC--NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCD------------ 955

Query: 419  CLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFE 478
                            V I  C  NPC                     G C  K   + +
Sbjct: 956  ----------------VPIHACISNPC------------------KHGGTCHLK-EGEED 980

Query: 479  YVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANG 538
              W +   G EGE C+  +D       +C  ++T V+    NN +C  P E T E+C   
Sbjct: 981  GFWCICADGFEGENCEVNVDDCE--DNDCENNSTCVDGI--NNYTCLCPPEYTGELCEEK 1036

Query: 539  CS-CLSEEDSQEYRYLCFLR-----------WAGNMYLENTTDDQENECQHEAVCKDEIN 586
               C  + +  ++   C L            + G     +  D Q+N+C++ A C D +N
Sbjct: 1037 LDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVN 1096

Query: 587  RPRYLCI 593
               Y CI
Sbjct: 1097 --GYTCI 1101



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 30/112 (26%), Positives = 45/112 (40%), Gaps = 11/112 (9%)

Query: 186  HGKCLSEAWSKTYSCHCQPPFSGKYCQEL--DACSFKPCKNNGSCINKRENWDEQAYECV 243
            HG C   + +  ++C CQ  + G  C +   D C    C + G+C+      +  +Y C 
Sbjct: 1343 HGTCQPSSQAG-FTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPI----NAFSYSCK 1396

Query: 244  CHPPFTGKNCSE---IIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCE 292
            C     G  C E   +   CQ   C HG C         CEC   ++G  C+
Sbjct: 1397 CLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCD 1448



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 31/118 (26%), Positives = 45/118 (38%), Gaps = 18/118 (15%)

Query: 493  CQGVIDAYFFLAAN------CTEDATYVNDPED----------NNSSCWFP-HEGTKEIC 535
            CQG +D       N      C  D T  +DP D              C  P H      C
Sbjct: 907  CQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPC 966

Query: 536  ANGCSC-LSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLC 592
             +G +C L E +   +  +C   + G     N  D ++N+C++ + C D IN    LC
Sbjct: 967  KHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLC 1024


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  107 bits (268), Expect = 2e-23
 Identities = 87/351 (24%), Positives = 131/351 (37%), Gaps = 27/351 (7%)

Query: 123  QLLFGCRLKGMHTVNSKWLSVGTHYFITVMA-----SGPSPCPLGLR-LNVTVKQQFCQE 176
            Q L   RL  +H  +   L  G    +T ++     + P  C   LR L+  VK  + + 
Sbjct: 829  QGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEP 888

Query: 177  SLSSEFCSG----HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
             ++   C+G     GK L    +K + C   P  + +   + D C   PC+N G+C N  
Sbjct: 889  GIAR--CAGPQDMEGKLLLTTPAKKFECQGPPTLAVQ--AKCDLCLSSPCQNQGTCHND- 943

Query: 233  ENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS---FICECDEQFSGP 289
                 + Y C C   + G++C   +  C    C +G   +        F C C   F GP
Sbjct: 944  ---PLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGP 1000

Query: 290  FCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGE--TDVSEFSLVPCQNGTDC 347
             C V+   CV       G+C +    YT +CP     +  E   D+    L PCQ+   C
Sbjct: 1001 TCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQC 1060

Query: 348  IKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE- 406
            +   +   C C P +    C   Q  C     +N A C      Y C C  G++ + CE 
Sbjct: 1061 VGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEI 1120

Query: 407  ---KAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLI 454
                           C N   C +   R    C+PG     C  L +V  +
Sbjct: 1121 PPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFV 1171



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 65/240 (27%), Positives = 92/240 (38%), Gaps = 34/240 (14%)

Query: 374  CESFPLRNNATCKKCEKD-YPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGR- 431
            C S P +N  TC     + Y C+C SG+  ++CE ++D C   S  C N   C    G  
Sbjct: 929  CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCS--SGPCENGGTCHAQEGED 986

Query: 432  --FKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSE 489
              F   C  G     C    N      H C  G    G+C D G   +     L +   E
Sbjct: 987  APFTCSCPTGFEGPTCGV--NTDDCVDHACANG----GVCVD-GVGNYTCQCPLQY---E 1036

Query: 490  GEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTK----------EICANGC 539
            G+ C+ ++D        C  +A  V  P+     C   + G              C NG 
Sbjct: 1037 GKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGA 1096

Query: 540  SCLSEEDSQEYRYLCFLRWAGNM-----YLENTTDDQEN-ECQHEAVCKDEINRPRYLCI 593
             C+ E +S  Y  LC   ++G +     +L       E  ECQ+ A C D+ NRP   C+
Sbjct: 1097 QCMDEVNS--YSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCL 1154



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 31/110 (28%), Positives = 47/110 (42%), Gaps = 7/110 (6%)

Query: 186  HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCH 245
            HG C   A +    CHC+  + G +C   D  +  PC  +     +    D  +Y C C 
Sbjct: 1349 HGICQPNA-TPGPMCHCEAGWVGLHC---DQPADGPCHGHKCVHGQCVPLDALSYSCQCQ 1404

Query: 246  PPFTGKNCSE---IIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCE 292
              ++G  C++   +   C+   C HG+C    +    C CD  FSG  CE
Sbjct: 1405 DGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 34/144 (23%), Positives = 56/144 (38%), Gaps = 43/144 (29%)

Query: 242  CVCHPPFTGKNCSEII-GQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVS---AKP 297
            C C   + G +C +   G C  H C HG C  + + S+ C+C + +SG  C  +   A+P
Sbjct: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEP 1421

Query: 298  CVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCI 357
            C       RG+          +C  G    +G                     +    C+
Sbjct: 1422 C-------RGL----------QCLHGHCQASG---------------------TKGAHCV 1443

Query: 358  CSPIFTDLLCKSIQTSCESFPLRN 381
            C P F+  LC+  ++ C   P+R+
Sbjct: 1444 CDPGFSGELCEQ-ESECRGDPVRD 1466



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 40/144 (27%), Positives = 61/144 (42%), Gaps = 18/144 (12%)

Query: 186  HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCH 245
            HG+C+    + +YSC CQ  +SG  C +  A + +PC+         +    +   CVC 
Sbjct: 1388 HGQCVPLD-ALSYSCQCQDGYSGALCNQAGALA-EPCRGLQCLHGHCQASGTKGAHCVCD 1445

Query: 246  PPFTGKNCSEIIGQCQ--PHVCFHGNCSNITSNSFICECDEQFSGPFCEVS--AKPCVSL 301
            P F+G+ C E   +C+  P   FH     +     IC+     S   C  S   + C   
Sbjct: 1446 PGFSGELC-EQESECRGDPVRDFH----QVQRGYAICQTTRPLSWVECRGSCPGQGCCQG 1500

Query: 302  LFWKRGICPNSSSAYTYECPKGSS 325
            L  KR         +T+EC  G+S
Sbjct: 1501 LRLKR-------RKFTFECSDGTS 1517



 Score = 32.7 bits (73), Expect = 0.97
 Identities = 33/128 (25%), Positives = 46/128 (35%), Gaps = 21/128 (16%)

Query: 175  QESLSSEFCSG----HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCIN 230
            Q    +E C G    HG C +   +K   C C P FSG+ C++   C   P ++      
Sbjct: 1414 QAGALAEPCRGLQCLHGHCQASG-TKGAHCVCDPGFSGELCEQESECRGDPVRDFHQV-- 1470

Query: 231  KRENWDEQAYE-CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
                  ++ Y  C    P +   C    G C    C  G    +    F  EC +  S  
Sbjct: 1471 ------QRGYAICQTTRPLSWVECR---GSCPGQGCCQG--LRLKRRKFTFECSDGTS-- 1517

Query: 290  FCEVSAKP 297
            F E   KP
Sbjct: 1518 FAEEVEKP 1525


>gi|74136023 delta-like 1 homolog [Homo sapiens]
          Length = 383

 Score =  105 bits (261), Expect = 2e-22
 Identities = 62/201 (30%), Positives = 92/201 (45%), Gaps = 17/201 (8%)

Query: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDACSFKPCKNNGSCINKR 232
           C + ++S  C  HG C      +   C C   + G+ C +++ ACS  PC NNG+C+   
Sbjct: 54  CDQCVTSPGCL-HGLC-----GEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCV--- 104

Query: 233 ENWDEQAYECVCHPPFTGKNCSEIIGQC--QPHVCFHGNC---SNITSNSFICECDEQFS 287
            + D+  YEC C P ++GK+C +  G C      C HG         ++   C C   FS
Sbjct: 105 -SLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFS 163

Query: 288 GPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDC 347
           G FCE+ A  C        G+C +    +   CP G   +     V+  +  PCQNG  C
Sbjct: 164 GNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTC 223

Query: 348 IKISN-DVMCICSPIFTDLLC 367
           ++ +     C+C P FT L C
Sbjct: 224 LQHTQVSYECLCKPEFTGLTC 244



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 60/251 (23%), Positives = 93/251 (37%), Gaps = 54/251 (21%)

Query: 200 CHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQ 259
           C CQP + G  C   D C   P   +G C         +  +C+C   + G+ C   +  
Sbjct: 43  CRCQPGWQGPLC---DQCVTSPGCLHGLC--------GEPGQCICTDGWDGELCDRDVRA 91

Query: 260 CQPHVCFH-GNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTY 318
           C    C + G C ++    + C C   +SG  C+    PCV                   
Sbjct: 92  CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI------------------ 133

Query: 319 ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKI---SNDVMCICSPIFTDLLCKSIQTSCE 375
                    NG          PCQ+G  C+     ++   C+C P F+   C+ +  SC 
Sbjct: 134 ---------NGS---------PCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCT 175

Query: 376 SFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCF-NIIGRFKY 434
             P  N+  C     D+ C C +GF +K C + + +C   S  C N   C  +    ++ 
Sbjct: 176 PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNC--ASSPCQNGGTCLQHTQVSYEC 233

Query: 435 VCIPGCTKNPC 445
           +C P  T   C
Sbjct: 234 LCKPEFTGLTC 244


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score =  101 bits (252), Expect = 2e-21
 Identities = 68/261 (26%), Positives = 108/261 (41%), Gaps = 17/261 (6%)

Query: 159  CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDAC 217
            C   + +N+  K   C   LSS  C  +G C  +   + Y C C   + GK C   ++ C
Sbjct: 905  CKGPVDINIVAK---CNACLSSP-CKNNGTCTQDP-VELYRCACPYSYKGKDCTVPINTC 959

Query: 218  SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
               PC++ G+C     + D   + C C   F G+ C      C+ + C +        N+
Sbjct: 960  IQNPCQHGGTCHLSDSHKD--GFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINN 1017

Query: 278  FICECDEQFSGPFCEVSAKPCVSLL--FWKRGICPNSSSAYTYECPKGSSSQNGETDVSE 335
            ++C C   ++G  C+     CV  L        C      ++ EC  G S +  ETD  +
Sbjct: 1018 YVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDD 1077

Query: 336  FSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKS------IQTS-CESFPLRNNATCKKC 388
                 C++G  C+   N   C C   F+   C+       +QTS C+ +  +N A C   
Sbjct: 1078 CVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVV 1137

Query: 389  EKDYPCSCISGFTEKNCEKAI 409
            +++  C C  GF    CEK I
Sbjct: 1138 QQEPTCRCPPGFAGPRCEKLI 1158



 Score =  100 bits (248), Expect = 5e-21
 Identities = 56/215 (26%), Positives = 88/215 (40%), Gaps = 9/215 (4%)

Query: 197  TYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
            T+   C+ P       + +AC   PCKNNG+C         + Y C C   + GK+C+  
Sbjct: 900  THRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQD----PVELYRCACPYSYKGKDCTVP 955

Query: 257  IGQCQPHVCFHGNCSNITSN---SFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSS 313
            I  C  + C HG   +++ +    F C C   F G  CE++   C          C +  
Sbjct: 956  INTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGI 1015

Query: 314  SAYTYECPKGSSSQNGETDVSEF--SLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQ 371
            + Y   CP   + +  +  +      L  CQ+   CI +     C C P ++  LC++  
Sbjct: 1016 NNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDN 1075

Query: 372  TSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
              C +   R+ A C      Y C+C  GF+   CE
Sbjct: 1076 DDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 1110



 Score = 82.8 bits (203), Expect = 8e-16
 Identities = 62/232 (26%), Positives = 82/232 (35%), Gaps = 78/232 (33%)

Query: 183  CSGHGKC-LSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAY 240
            C   G C LS++    +SC C   F G+ C+   D C    C+NN +C++   N     Y
Sbjct: 964  CQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINN-----Y 1018

Query: 241  ECVCHPPFTGKNCSEIIGQCQP-------------------------------------- 262
             C+C P +TG+ C E+I  C P                                      
Sbjct: 1019 VCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDC 1078

Query: 263  --HVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYEC 320
              H C HG     T N + C C + FSGPFCE    P V L          +S    YE 
Sbjct: 1079 VAHKCRHGAQCVDTINGYTCTCPQGFSGPFCE-HPPPMVLL---------QTSPCDQYE- 1127

Query: 321  PKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQT 372
                                CQNG  CI +  +  C C P F    C+ + T
Sbjct: 1128 --------------------CQNGAQCIVVQQEPTCRCPPGFAGPRCEKLIT 1159



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 45/176 (25%), Positives = 66/176 (37%), Gaps = 6/176 (3%)

Query: 298  CVSLLFWKRGICPNSS-SAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI---KISND 353
            C+S      G C       Y   CP     ++    ++     PCQ+G  C       + 
Sbjct: 920  CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979

Query: 354  VMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCK 413
              C C   F    C+     CE     NNATC     +Y C C   +T + C++ IDHC 
Sbjct: 980  FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCV 1039

Query: 414  LLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIH--QHLCYCGVTFHG 467
                 C +E  C  +   F   C+PG +   C    +  + H  +H   C  T +G
Sbjct: 1040 PELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTING 1095



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 5/109 (4%)

Query: 264  VCFHGNCSNITSNSFICECDEQFSGPFCEVSAK-PCVSLLFWKRGICPNSSSAYTYECPK 322
            VC HG C ++  +S +CEC   ++GP C+  A+ PC+       G C  + ++Y  +C +
Sbjct: 1337 VCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHR-CHHGKCVATGTSYMCKCAE 1395

Query: 323  GSSS---QNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCK 368
            G       N     +  S   C +G   I    +  C+C P F+   C+
Sbjct: 1396 GYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ 1444



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 39/154 (25%), Positives = 58/154 (37%), Gaps = 20/154 (12%)

Query: 186  HGKCLSEAWSKTYSCHCQPPFSGKYCQE--LDACSFKPCKNNGSCINKRENWDEQAYECV 243
            HG C S     +  C C+P ++G  C +   D C    C ++G C+    +     Y C 
Sbjct: 1340 HGLCRSVE-KDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTS-----YMCK 1392

Query: 244  CHPPFTGKNC---SEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCV- 299
            C   + G  C   ++    C    C HG C         C C   FSG  C+    PC+ 
Sbjct: 1393 CAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ-QENPCLG 1451

Query: 300  ----SLLFWKRGI--CPNSSSAYTYECPKGSSSQ 327
                 ++  ++G   C  +S     EC  G   Q
Sbjct: 1452 QVVREVIRRQKGYASCATASKVPIMECRGGCGPQ 1485



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 31/120 (25%), Positives = 51/120 (42%), Gaps = 20/120 (16%)

Query: 492  KCQGVIDAYFFLAAN------CTEDATYVNDP-EDNNSSCWFPHEGT----------KEI 534
            +C+G +D       N      C  + T   DP E    +C + ++G           +  
Sbjct: 904  QCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNP 963

Query: 535  CANGCSC-LSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRYLCI 593
            C +G +C LS+     +   C L + G     N  D ++N+C++ A C D IN   Y+CI
Sbjct: 964  CQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGIN--NYVCI 1021



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 57/240 (23%), Positives = 88/240 (36%), Gaps = 66/240 (27%)

Query: 360  PIFTDLLCKSIQTSCESFPLRNNATCKKCEKD-YPCSCISGFTEKNCEKAIDHCKLLSIN 418
            P+  +++ K    +C S P +NN TC +   + Y C+C   +  K+C             
Sbjct: 908  PVDINIVAKC--NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCT------------ 953

Query: 419  CLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFE 478
                            V I  C +NPC          QH    G T H    D     F 
Sbjct: 954  ----------------VPINTCIQNPC----------QH----GGTCH--LSDSHKDGFS 981

Query: 479  YVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANG 538
                LGF   EG++C+  I+       +C  +AT V+    NN  C  P   T E+C   
Sbjct: 982  CSCPLGF---EGQRCE--INPDDCEDNDCENNATCVDGI--NNYVCICPPNYTGELCDEV 1034

Query: 539  CS-CLSEEDSQEYRYLCFLR-----------WAGNMYLENTTDDQENECQHEAVCKDEIN 586
               C+ E +  ++   C              ++G +   +  D   ++C+H A C D IN
Sbjct: 1035 IDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTIN 1094



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 16/38 (42%), Positives = 22/38 (57%), Gaps = 1/38 (2%)

Query: 180  SEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDAC 217
            S F   HG+C      + Y C CQP FSG++CQ+ + C
Sbjct: 1413 SAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQQENPC 1449



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 29/118 (24%), Positives = 46/118 (38%), Gaps = 11/118 (9%)

Query: 337  SLVPCQNGTDCIKISND-VMCICSPIFTDLLC-KSIQTSCESFPLRNNATCKKCEKDYPC 394
            S   C++G  C  +  D V+C C P +T  LC +  +  C      ++  C      Y C
Sbjct: 1334 SCTVCKHGL-CRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMC 1391

Query: 395  SCISGFTEKNCEKAIDHCKLLS-INCLNEEWCFNIIGRFKYVCIPGCT------KNPC 445
             C  G+    C+   D     S   C + +   +  G    +C PG +      +NPC
Sbjct: 1392 KCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPC 1449


>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
          Length = 618

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 76/298 (25%), Positives = 103/298 (34%), Gaps = 51/298 (17%)

Query: 197 TYSCHCQPPFSGKYCQEL---------------------DACSFKPCKNNGSCINKRENW 235
           +Y   C+PP  G  C  L                     D C   P      C +    +
Sbjct: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECE-APLVCRAGC-SPEHGF 230

Query: 236 DEQAYECVCHPPFTGKNCSEII-----------------------GQCQPHVCFHGNCSN 272
            EQ  EC C   +TG  C+  +                       G C  + C +G   +
Sbjct: 231 CEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCS 290

Query: 273 ITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSS---SAYTYECPKGSSSQNG 329
            T  SF C C   F G  CEVS   C     +  G+C   +   SAY   CP G    N 
Sbjct: 291 ETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNC 350

Query: 330 ETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCE 389
           E  V   SL PC+NG  C+ + + + C C   F    C+     C      N  TC +  
Sbjct: 351 EKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGG 410

Query: 390 KDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWF 447
             + CSC  GF  ++C +  D C   +  C +   C+         C PG     C F
Sbjct: 411 GAHRCSCALGFGGRDCRERADPC--AARPCAHGGRCYAHFSGLVCACAPGYMGARCEF 466



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 49/187 (26%), Positives = 76/187 (40%), Gaps = 5/187 (2%)

Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA-CSFKPCKNNGSCINKRENWDEQAYE 241
           C+  G C SE   +++ C C   F G  C+     C+  PC N G C+   +   + AY 
Sbjct: 283 CANGGSC-SET-PRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGAD--PDSAYI 338

Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
           C C P F G NC + + +C    C +G       ++  C C   F+GP CE     C   
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398

Query: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
                G C     A+   C  G   ++        +  PC +G  C    + ++C C+P 
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPG 458

Query: 362 FTDLLCK 368
           +    C+
Sbjct: 459 YMGARCE 465



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 38/140 (27%), Positives = 57/140 (40%), Gaps = 11/140 (7%)

Query: 159 CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDAC 217
           CP G + +   K+    +  S + C   G CL         C C+  F+G  C+ +LD C
Sbjct: 341 CPPGFQGSNCEKRV---DRCSLQPCRNGGLCLD--LGHALRCRCRAGFAGPRCEHDLDDC 395

Query: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
           + + C N G+C+         A+ C C   F G++C E    C    C HG       + 
Sbjct: 396 AGRACANGGTCVE-----GGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSG 450

Query: 278 FICECDEQFSGPFCEVSAKP 297
            +C C   + G  CE    P
Sbjct: 451 LVCACAPGYMGARCEFPVHP 470


>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
          Length = 587

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 76/298 (25%), Positives = 103/298 (34%), Gaps = 51/298 (17%)

Query: 197 TYSCHCQPPFSGKYCQEL---------------------DACSFKPCKNNGSCINKRENW 235
           +Y   C+PP  G  C  L                     D C   P      C +    +
Sbjct: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECE-APLVCRAGC-SPEHGF 230

Query: 236 DEQAYECVCHPPFTGKNCSEII-----------------------GQCQPHVCFHGNCSN 272
            EQ  EC C   +TG  C+  +                       G C  + C +G   +
Sbjct: 231 CEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCS 290

Query: 273 ITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSS---SAYTYECPKGSSSQNG 329
            T  SF C C   F G  CEVS   C     +  G+C   +   SAY   CP G    N 
Sbjct: 291 ETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNC 350

Query: 330 ETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCE 389
           E  V   SL PC+NG  C+ + + + C C   F    C+     C      N  TC +  
Sbjct: 351 EKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGG 410

Query: 390 KDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWF 447
             + CSC  GF  ++C +  D C   +  C +   C+         C PG     C F
Sbjct: 411 GAHRCSCALGFGGRDCRERADPC--AARPCAHGGRCYAHFSGLVCACAPGYMGARCEF 466



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 49/187 (26%), Positives = 76/187 (40%), Gaps = 5/187 (2%)

Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA-CSFKPCKNNGSCINKRENWDEQAYE 241
           C+  G C SE   +++ C C   F G  C+     C+  PC N G C+   +   + AY 
Sbjct: 283 CANGGSC-SET-PRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGAD--PDSAYI 338

Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
           C C P F G NC + + +C    C +G       ++  C C   F+GP CE     C   
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398

Query: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
                G C     A+   C  G   ++        +  PC +G  C    + ++C C+P 
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPG 458

Query: 362 FTDLLCK 368
           +    C+
Sbjct: 459 YMGARCE 465



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 38/140 (27%), Positives = 57/140 (40%), Gaps = 11/140 (7%)

Query: 159 CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDAC 217
           CP G + +   K+    +  S + C   G CL         C C+  F+G  C+ +LD C
Sbjct: 341 CPPGFQGSNCEKRV---DRCSLQPCRNGGLCLD--LGHALRCRCRAGFAGPRCEHDLDDC 395

Query: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
           + + C N G+C+         A+ C C   F G++C E    C    C HG       + 
Sbjct: 396 AGRACANGGTCVE-----GGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSG 450

Query: 278 FICECDEQFSGPFCEVSAKP 297
            +C C   + G  CE    P
Sbjct: 451 LVCACAPGYMGARCEFPVHP 470


>gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]
          Length = 236

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 58/216 (26%), Positives = 93/216 (43%), Gaps = 17/216 (7%)

Query: 200 CHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQ 259
           C C   F G+YCQ  D C    C+N G+C+ +          C C   FTG++C      
Sbjct: 12  CKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKA---TCRCASGFTGEDCQ----Y 64

Query: 260 CQPHVCF-------HGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNS 312
              H CF        G C  ++ +++ C C   F+G  C+ +   C+S        C   
Sbjct: 65  STSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTV 123

Query: 313 SSAYTYECPKGSSSQNGETDVSEFSLV-PCQNGTDCIKISNDVMCICSPIFTDLLCKSIQ 371
           ++ ++ +C  G + Q  ETDV+E  +   CQ+G  C+ +     C C   FT   C S+ 
Sbjct: 124 ANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLY 183

Query: 372 TSCESFPLRNNATCKKC-EKDYPCSCISGFTEKNCE 406
             C   P  N  TC++  +  + C+C+     +  E
Sbjct: 184 VPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTE 219



 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 55/196 (28%), Positives = 83/196 (42%), Gaps = 12/196 (6%)

Query: 172 QFCQ--ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA--CSF-KPCKNNG 226
           ++CQ  +      C   G C+++A     +C C   F+G+ CQ   +  C   +PC N G
Sbjct: 21  EYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGG 80

Query: 227 SCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQF 286
           +C           YEC C   FTGK C +    C  H C +G+     +N F C+C   F
Sbjct: 81  TC----HMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCANGSTCTTVANQFSCKCLTGF 135

Query: 287 SGPFCEVSAKPC-VSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGT 345
           +G  CE     C +       G C N   +Y  +C +G + Q  ++     +  PC NG 
Sbjct: 136 TGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGG 195

Query: 346 DCIKISNDVM-CICSP 360
            C +  +    C C P
Sbjct: 196 TCRQTGDFTFECNCLP 211



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 50/181 (27%), Positives = 77/181 (42%), Gaps = 8/181 (4%)

Query: 270 CSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSS--SAYTYECPKGSSSQ 327
           C    + +  C+C E F G +C+    PC        G C   +     T  C  G + +
Sbjct: 2   CVTYHNGTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60

Query: 328 NGETDVSEFSLV--PCQNGTDCIKISNDVM-CICSPIFTDLLCKSIQTSCESFPLRNNAT 384
           + +   S    V  PC NG  C  +S D   C C   FT   C+    +C S P  N +T
Sbjct: 61  DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD-ACLSHPCANGST 119

Query: 385 CKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNP 444
           C      + C C++GFT + CE  ++ C +   +C +   C N+ G ++  C+ G T   
Sbjct: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIPG-HCQHGGTCLNLPGSYQCQCLQGFTGQY 178

Query: 445 C 445
           C
Sbjct: 179 C 179


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 84/317 (26%), Positives = 118/317 (37%), Gaps = 55/317 (17%)

Query: 155  GPSPCPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFS----GKY 210
            G   C      + T  + FC +       +G  +        +Y C CQP F+     + 
Sbjct: 1176 GKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRS 1235

Query: 211  CQELDACSFKP-CKNNGSCINKRENWDEQAYECVCHPPFTG----KNCSEIIGQC--QPH 263
            C ++D C   P   + G C N         Y C+C+  F      K C + + +C   P+
Sbjct: 1236 CTDIDECEDNPNICDGGQCTN-----IPGEYRCLCYDGFMASEDMKTCVD-VNECDLNPN 1289

Query: 264  VCFHGNCSNITSNSFICECDEQFSGP----------FCEVSAKPCVSLLFWKRGICPNSS 313
            +C  G C N T  SFIC CD  +SG            CE+ A  C      K  +C N++
Sbjct: 1290 ICLSGTCEN-TKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNC-----GKHAVCTNTA 1343

Query: 314  SAYTYECPKGSSSQNGE-TDVSEFSLVPCQNGT-------DCIKISNDVMCICSPIFT-- 363
             ++   C  G      + TD+ E     C NGT       DC        C+C   +T  
Sbjct: 1344 GSFKCSCSPGWIGDGIKCTDLDE-----CSNGTHMCSQHADCKNTMGSYRCLCKEGYTGD 1398

Query: 364  DLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTE----KNCEKAIDHCKLLSINC 419
               C  +    E+  L  N  C      Y C C  GF      K CE  ID C L +I  
Sbjct: 1399 GFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACED-IDECSLPNICV 1457

Query: 420  LNEEWCFNIIGRFKYVC 436
                 C N+ G F+  C
Sbjct: 1458 FGT--CHNLPGLFRCEC 1472



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 95/328 (28%), Positives = 128/328 (39%), Gaps = 58/328 (17%)

Query: 197  TYSCHCQPPFS----GKYCQELDACSFKP--CKNNGSCINKRENWDEQAYECVCHPPFTG 250
            TY C C P +     G+ C + + C  KP  C+N G C+N R +     Y C C+  FT 
Sbjct: 2271 TYMCICGPGYQRRPDGEGCVDENECQTKPGICEN-GRCLNTRGS-----YTCECNDGFTA 2324

Query: 251  K-NCSEII----GQCQPHV----CFHGNCSNITSNSFICECDEQFS-GPFCEVSAKPCVS 300
              N  E +    G C   V    C  G+ +        C CD     GP CE        
Sbjct: 2325 SPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCE-------- 2376

Query: 301  LLFWKRGICP-NSSSAYTYECPKGSSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCI 357
                   ICP   + A+   CP G        D+ E  ++   C+NG +C+       CI
Sbjct: 2377 -------ICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNG-ECVNDRGSYHCI 2428

Query: 358  C----SPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGF----TEKNCEKAI 409
            C    +P  T   C  +   C   P   N  CK  E  Y CSC  G+      ++C K +
Sbjct: 2429 CKTGYTPDITGTSCVDLN-ECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSC-KDL 2486

Query: 410  DHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGIC 469
            D C     NC  +  C N IG F   C PG T++    + N       +  CG    GIC
Sbjct: 2487 DECATKQHNC--QFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECT-SDINLCG--SKGIC 2541

Query: 470  QDKGPAQFEYVWQLGFA-GSEGEKCQGV 496
            Q+  P  F    Q GF+    G  C+ V
Sbjct: 2542 QNT-PGSFTCECQRGFSLDQTGSSCEDV 2568



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 86/325 (26%), Positives = 130/325 (40%), Gaps = 73/325 (22%)

Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPF----SGKYCQELDACSFKPCKNNGSCINK 231
           E L +     +G+C++   S  + C C   F     GK C+++D CS +    NG CIN 
Sbjct: 533 ECLQNGRICNNGRCINTDGS--FHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCIN- 589

Query: 232 RENWDEQAYECVCHPPF----TGKNCSEIIGQCQ-PHVCFHGNCSNITSNSFICECDEQF 286
               ++ +++C+C P F     G+ C + I +C+ P +C +G C N T  S+ CEC   F
Sbjct: 590 ----EDGSFKCICKPGFQLASDGRYCKD-INECETPGICMNGRCVN-TDGSYRCEC---F 640

Query: 287 SGPFCEVSAKPCVSLLF-------WKRGIC------------------------------ 309
            G    +  + CV           +KRG C                              
Sbjct: 641 PGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCP 700

Query: 310 PNSSSAYTYECPKGSSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCICSPIF----T 363
             +S+ Y   C  G    +  +D++E +L P  C NG  C  +     CIC+  +    T
Sbjct: 701 AQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGI-CENLRGTYKCICNSGYEVDST 759

Query: 364 DLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTE----KNCEKAIDHCKLLSINC 419
              C  I     +  L +N  C+     + C+C  GF      K CE  ID C+  S  C
Sbjct: 760 GKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCED-IDECE--SSPC 816

Query: 420 LNEEWCFNIIGRFKYVCIPGCTKNP 444
           +N   C N  G F   C    T +P
Sbjct: 817 INGV-CKNSPGSFICECSSESTLDP 840



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 72/291 (24%), Positives = 109/291 (37%), Gaps = 42/291 (14%)

Query: 178  LSSEFCSGHGKCLSEAWSKTYSCHCQPPFSG-----KYCQELDACSFKPCKNNGSCINKR 232
            +S + C G G+C++      + C C   +       K C ++D C   P    G   +  
Sbjct: 1076 ISPDLC-GRGQCVNTPGD--FECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNT 1132

Query: 233  ENWDEQAYECVCHPPFTGKNCSEIIGQC--------QPHVCFHGNCSNITSNSFICECDE 284
            E     +Y C C P   G   S  I  C          H+C +G C N+    + C C+ 
Sbjct: 1133 EG----SYRCECPP---GHQLSPNISACIDINECELSAHLCPNGRCVNLIGK-YQCACNP 1184

Query: 285  QFSGP----FCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSS---SQNGETDVSEFS 337
             +       FC V    C  +       C NS  +Y   C  G +    Q   TD+ E  
Sbjct: 1185 GYHSTPDRLFC-VDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECE 1243

Query: 338  LVP--CQNGTDCIKISNDVMCICSPIFT---DLLCKSIQTSCESFP-LRNNATCKKCEKD 391
              P  C  G  C  I  +  C+C   F    D+        C+  P +  + TC+  +  
Sbjct: 1244 DNPNICDGG-QCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGS 1302

Query: 392  YPCSCISGFTEKNCEKA---IDHCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
            + C C  G++ K  +     I+ C++ + NC     C N  G FK  C PG
Sbjct: 1303 FICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPG 1353



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 103/468 (22%), Positives = 176/468 (37%), Gaps = 103/468 (22%)

Query: 159  CPLGLRL--NVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGK----YCQ 212
            CP G +L  N++      +  LS+  C  +G+C++      Y C C P +       +C 
Sbjct: 1140 CPPGHQLSPNISACIDINECELSAHLCP-NGRCVNLIGK--YQCACNPGYHSTPDRLFCV 1196

Query: 213  ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFT----GKNCSEIIGQCQ--PHVCF 266
            ++D CS      NG C     N  E +YEC C P F      ++C++I  +C+  P++C 
Sbjct: 1197 DIDECSIM----NGGCETFCTN-SEGSYECSCQPGFALMPDQRSCTDI-DECEDNPNICD 1250

Query: 267  HGNCSNITSNSFICECDEQFSGPF----------CEVSAKPCVSLLFWKRGICPNSSSAY 316
             G C+NI    + C C + F              C+++   C+S      G C N+  ++
Sbjct: 1251 GGQCTNIPGE-YRCLCYDGFMASEDMKTCVDVNECDLNPNICLS------GTCENTKGSF 1303

Query: 317  TYECPKGSSSQNGETDVSEFSLVPCQNGT-DCIKISNDVMCICSPIFTDLLCKSIQTSCE 375
               C  G S + G+T  ++ +   C+ G  +C K                          
Sbjct: 1304 ICHCDMGYSGKKGKTGCTDIN--ECEIGAHNCGK-------------------------- 1335

Query: 376  SFPLRNNATCKKCEKDYPCSCISGFTEKNCEKA-IDHCKLLSINCLNEEWCFNIIGRFKY 434
                  +A C      + CSC  G+     +   +D C   +  C     C N +G ++ 
Sbjct: 1336 ------HAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRC 1389

Query: 435  VCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGS-EGEKC 493
            +C  G T +  +   ++    ++L  CG   +G C +  P  +     +GF  S +G+ C
Sbjct: 1390 LCKEGYTGDG-FTCTDLDECSENLNLCG---NGQCLN-APGGYRCECDMGFVPSADGKAC 1444

Query: 494  QGVID------AYFFLAAN------CTEDATYVNDPEDNN----SSCWFPHEGTKEICAN 537
            + + +        F    N      C  +  Y  D    N    + C  P       C N
Sbjct: 1445 EDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVN 1504

Query: 538  G-----CSCLSEEDSQEYRYLCFLRWAGNMYLE--NTTDDQENECQHE 578
                  C C  + +    R  C    +GN YL+     D+ +  C +E
Sbjct: 1505 TPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNE 1552



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 77/280 (27%), Positives = 107/280 (38%), Gaps = 41/280 (14%)

Query: 186  HGKCLSEAWSKTYSCHCQPPFSGK----YCQELDACSFKP-CKNNGSCINKRENWDEQAY 240
            +G C++   S  + C C   F        C+++D C   P C+ N  CIN   +     Y
Sbjct: 1779 NGVCINMVGS--FRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGS-----Y 1831

Query: 241  ECVCHPP--FTGKNCSEIIGQCQ--PHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAK 296
             C C P   FT         +CQ  P++C HG C + T  SF C C   F          
Sbjct: 1832 RCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCID-TVGSFYCLCHTGFK---TNDDQT 1887

Query: 297  PCVSLLFWKR-----GICPNSSSAYTYECPKGS--SSQNGETDVSEFSLVP---CQNGTD 346
             C+ +   +R     G C N+  ++   C  G   S  N   DV E +      C+NG  
Sbjct: 1888 MCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNG-Q 1946

Query: 347  CIKISNDVMCICSPIFT----DLLCKSIQTSCESFPLR-NNATCKKCEKDYPCSCISGFT 401
            CI       C C+  +        C  I   C   P +    TC+  +  Y C C  G++
Sbjct: 1947 CINTVGSFQCQCNEGYEVAPDGRTCVDIN-ECLLEPRKCAPGTCQNLDGSYRCICPPGYS 2005

Query: 402  EKN--CEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
             +N  CE  ID C      C     C N  G FK +C  G
Sbjct: 2006 LQNEKCED-IDECVEEPEICALGT-CSNTEGSFKCLCPEG 2043



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 74/302 (24%), Positives = 111/302 (36%), Gaps = 66/302 (21%)

Query: 197  TYSCHCQPPFS--GKYCQELDACSFKP--CKNNGSCINKRENWDEQAYECVCHPPFT--- 249
            +Y C C P +S   + C+++D C  +P  C   G+C N      E +++C+C   F+   
Sbjct: 1995 SYRCICPPGYSLQNEKCEDIDECVEEPEICAL-GTCSNT-----EGSFKCLCPEGFSLSS 2048

Query: 250  -GKNCSEIIGQCQPHVCFH----GNCS-----NITSNSFICECDEQFSGPFCE------- 292
             G+ C ++    +   C+     G CS     N +     C    +  G  CE       
Sbjct: 2049 SGRRCQDL----RMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPD 2104

Query: 293  ---------------------VSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGE- 330
                                 V    C      K G C N+  +Y  ECP G      E 
Sbjct: 2105 EAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNEC 2164

Query: 331  TDVSEFSLV-PCQNGTDCIKISNDVMCICSPIFTD---LLCKSIQTSCESFPLRNNATCK 386
             D  E S+  PC NGT C  +     C C   F     + C+ I   C   PL     C 
Sbjct: 2165 VDTDECSVGNPCGNGT-CKNVIGGFECTCEEGFEPGPMMTCEDIN-ECAQNPLLCAFRCV 2222

Query: 387  KCEKDYPCSCISGFT---EKNCEKAIDHCKLLSINCLNEEW-CFNIIGRFKYVCIPGCTK 442
                 Y C C  G+    ++   K  D C+    +C  ++  C N+IG +  +C PG  +
Sbjct: 2223 NTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQR 2282

Query: 443  NP 444
             P
Sbjct: 2283 RP 2284



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 78/296 (26%), Positives = 109/296 (36%), Gaps = 60/296 (20%)

Query: 177  SLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGK--YCQELDACS--FKPCKNNGSCINKR 232
            S  +  CS H  C +   S  Y C C+  ++G    C +LD CS     C  NG C+N  
Sbjct: 1368 SNGTHMCSQHADCKNTMGS--YRCLCKEGYTGDGFTCTDLDECSENLNLC-GNGQCLNA- 1423

Query: 233  ENWDEQAYECVCH----PPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQF-- 286
                   Y C C     P   GK C +I     P++C  G C N+    F CEC+  +  
Sbjct: 1424 ----PGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNL-PGLFRCECEIGYEL 1478

Query: 287  --SGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNG 344
              SG  C      C+       G C N+  +Y  +CP      + E + +    V  ++G
Sbjct: 1479 DRSGGNC-TDVNECLDPTTCISGNCVNTPGSYICDCP-----PDFELNPTRVGCVDTRSG 1532

Query: 345  TDCIKI-----------SNDV-------MCICSPIFTDLLCKSIQTSCESFPLRNNATCK 386
               + I           SN++        C CS      L K+  T CE  P  N +   
Sbjct: 1533 NCYLDIRPRGDNGDTACSNEIGVGVSKASCCCS------LGKAWGTPCEMCPAVNTS--- 1583

Query: 387  KCEKDYPCSCISGFTEKNCE---KAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
              E    C    GF         + ID C+ L   C   + C N  G F+  C  G
Sbjct: 1584 --EYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGK-CINTFGSFQCRCPTG 1636



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 74/278 (26%), Positives = 112/278 (40%), Gaps = 39/278 (14%)

Query: 186  HGKCLSEAWSKTYSCHCQ----PPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYE 241
            +G+C+++  S  Y C C+    P  +G  C +L+ C+  P   N  C N      E +Y+
Sbjct: 2415 NGECVNDRGS--YHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNT-----EGSYQ 2467

Query: 242  CVCHPPFT----GKNCSEIIGQC--QPHVCFHGNCSNITSNSFICECDEQFSGPFCE-VS 294
            C C   +     G++C ++  +C  + H C    C N T   F C+C   F+      + 
Sbjct: 2468 CSCPKGYILQEDGRSCKDL-DECATKQHNC-QFLCVN-TIGGFTCKCPPGFTQHHTSCID 2524

Query: 295  AKPCVS--LLFWKRGICPNSSSAYTYECPKGSS-SQNGET--DVSEFS-LVPCQNGTDCI 348
               C S   L   +GIC N+  ++T EC +G S  Q G +  DV E      CQ+G  C 
Sbjct: 2525 NNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHG--CQ 2582

Query: 349  KISNDVMCICSPIFTDLL----CKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKN 404
             I     C C   +        C   +  C S  +   A+C      Y C C +GF  + 
Sbjct: 2583 NIIGGYRCSCPQGYLQHYQWNQCVD-ENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQ 2641

Query: 405  CE---KAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
                 + I+ C      C     C N  G +   C PG
Sbjct: 2642 FSGGCQDINECGSAQAPC--SYGCSNTEGGYLCGCPPG 2677



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 76/318 (23%), Positives = 122/318 (38%), Gaps = 51/318 (16%)

Query: 186  HGKCLSEAWSKTYSCHCQPPFS----GKYCQELDACSFKPCK-NNGSCINKRENWDEQAY 240
            +G+C++   S  + C C   +     G+ C +++ C  +P K   G+C N      + +Y
Sbjct: 1944 NGQCINTVGS--FQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNL-----DGSY 1996

Query: 241  ECVCHPPFTGKNCS-EIIGQC--QPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKP 297
             C+C P ++ +N   E I +C  +P +C  G CSN T  SF C C E FS      S + 
Sbjct: 1997 RCICPPGYSLQNEKCEDIDECVEEPEICALGTCSN-TEGSFKCLCPEGFS---LSSSGRR 2052

Query: 298  CVSLLF------WKRGIC--PNSSSAYTYEC-------PKGSSSQNGETDVSEFSLVPCQ 342
            C  L        ++ G C  P S +    EC         G   +   T+  E     C 
Sbjct: 2053 CQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICP 2112

Query: 343  NGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTE 402
             G+  I   +D     S +  D         C+   +  +  C   +  Y C C  G+  
Sbjct: 2113 YGSGIIVGPDD-----SAVDMD--------ECKEPDVCKHGQCINTDGSYRCECPFGYIL 2159

Query: 403  KNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCG 462
               E  +D  +    N      C N+IG F+  C  G    P    +++    Q+   C 
Sbjct: 2160 AGNE-CVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCA 2218

Query: 463  ---VTFHGICQDKGPAQF 477
               V  +G  + K P  +
Sbjct: 2219 FRCVNTYGSYECKCPVGY 2236



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 45/145 (31%), Positives = 62/145 (42%), Gaps = 14/145 (9%)

Query: 305 KRGICPNSSSAYTYECPKGSSSQ-NGET-DVSEFSLVPCQNGTDCIKISNDVMCICSPIF 362
           + G C  +  +   EC KG      GE  DV E    PC  G +CI       C C   +
Sbjct: 461 QNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGG-ECINNQGSYTCQCRAGY 519

Query: 363 TDLL----CKSIQTSCESFPLRNNATCKKCEKDYPCSCISGF----TEKNCEKAIDHCKL 414
              L    C+ I    ++  + NN  C   +  + C C +GF      KNCE  +D C +
Sbjct: 520 QSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCED-MDECSI 578

Query: 415 LSINCLNEEWCFNIIGRFKYVCIPG 439
            ++ CLN   C N  G FK +C PG
Sbjct: 579 RNM-CLN-GMCINEDGSFKCICKPG 601



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 65/262 (24%), Positives = 89/262 (33%), Gaps = 57/262 (21%)

Query: 202  CQPPFSGKYCQELDACSFKPCKNNGSCIN-KRENWDEQAYECVCHPPFT------GKNCS 254
            C  P +G++  +   CS         C      N  E    C   P F       GK   
Sbjct: 967  CTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFF 1026

Query: 255  EIIGQCQ--PHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNS 312
            + I +C+  P +C HG C N T  SF C CD   SG   +   + C              
Sbjct: 1027 KDINECKMIPSLCTHGKCRN-TIGSFKCRCD---SGFALDSEERNC-------------- 1068

Query: 313  SSAYTYECPKGSSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCICSPIFTD--LLCK 368
                              TD+ E  + P  C  G  C+    D  C C   +    ++ K
Sbjct: 1069 ------------------TDIDECRISPDLCGRG-QCVNTPGDFECKCDEGYESGFMMMK 1109

Query: 369  SIQT--SCESFPLR-NNATCKKCEKDYPCSCISGFT-EKNCEKAID--HCKLLSINCLNE 422
            +      C+  PL      C   E  Y C C  G     N    ID   C+L +  C N 
Sbjct: 1110 NCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNG 1169

Query: 423  EWCFNIIGRFKYVCIPGCTKNP 444
              C N+IG+++  C PG    P
Sbjct: 1170 R-CVNLIGKYQCACNPGYHSTP 1190



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 56/211 (26%), Positives = 81/211 (38%), Gaps = 44/211 (20%)

Query: 257  IGQCQ--PHVCFHGNCSNITSNSFICEC----------------DEQFSGPFCEVSAKPC 298
            I +C+  P VC +G C N+   SF CEC                DE  +GP C+ +A+  
Sbjct: 1767 IDECREIPGVCENGVCINMVG-SFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAE-- 1823

Query: 299  VSLLFWKRGICPNSSSAYTYECPKGS--SSQNGETDVSEFSLVP--CQNGTDCIKISNDV 354
                      C N++ +Y  +C  G   +S     D +E   +P  C +G  CI      
Sbjct: 1824 ----------CINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHG-QCIDTVGSF 1872

Query: 355  MCICSPIFT----DLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGF--TEKNCEKA 408
             C+C   F       +C  I   CE      N TC+     + C C  GF  +  N    
Sbjct: 1873 YCLCHTGFKTNDDQTMCLDIN-ECERDAC-GNGTCRNTIGSFNCRCNHGFILSHNNDCID 1930

Query: 409  IDHCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
            +D C   + N      C N +G F+  C  G
Sbjct: 1931 VDECASGNGNLCRNGQCINTVGSFQCQCNEG 1961



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 58/209 (27%), Positives = 85/209 (40%), Gaps = 35/209 (16%)

Query: 174  CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGK----YCQELDACSFKPCKNNGSCI 229
            CQE      CS HG+C+    S  + C C   F        C +++ C    C  NG+C 
Sbjct: 1853 CQEI--PNICS-HGQCIDTVGS--FYCLCHTGFKTNDDQTMCLDINECERDAC-GNGTCR 1906

Query: 230  NKRENWDEQAYECVCHPPFTGKNCSEIIG--QCQP---HVCFHGNCSNITSNSFICECDE 284
            N   +     + C C+  F   + ++ I   +C     ++C +G C N T  SF C+C+E
Sbjct: 1907 NTIGS-----FNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCIN-TVGSFQCQCNE 1960

Query: 285  QFSGPFCEVSAKPCVSL---LFWKR----GICPNSSSAYTYECPKGSSSQNGE-TDVSEF 336
             +         + CV +   L   R    G C N   +Y   CP G S QN +  D+ E 
Sbjct: 1961 GYE---VAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDEC 2017

Query: 337  SLVP--CQNGTDCIKISNDVMCICSPIFT 363
               P  C  GT C        C+C   F+
Sbjct: 2018 VEEPEICALGT-CSNTEGSFKCLCPEGFS 2045



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 69/271 (25%), Positives = 101/271 (37%), Gaps = 65/271 (23%)

Query: 159  CPLGLRLNV-----TVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPF----SGK 209
            CP G  + V      V    C+E    + C  HG+C++   S  Y C C  PF    +G 
Sbjct: 2111 CPYGSGIIVGPDDSAVDMDECKEP---DVCK-HGQCINTDGS--YRCEC--PFGYILAGN 2162

Query: 210  YCQELDACSF-KPCKNNGSCINKRENWDEQAYECVCHPPFTG---KNCSEIIGQCQPHVC 265
             C + D CS   PC  NG+C N         +EC C   F       C +I    Q  + 
Sbjct: 2163 ECVDTDECSVGNPC-GNGTCKNV-----IGGFECTCEEGFEPGPMMTCEDINECAQNPLL 2216

Query: 266  FHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSS 325
                C N T  S+ C+C              P   +L   R +C +       EC     
Sbjct: 2217 CAFRCVN-TYGSYECKC--------------PVGYVLREDRRMCKDED-----EC----- 2251

Query: 326  SQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIF---TDLLCKSIQTSCESFP-LRN 381
             + G+ D +E  +       +C  +    MCIC P +    D      +  C++ P +  
Sbjct: 2252 -EEGKHDCTEKQM-------ECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICE 2303

Query: 382  NATCKKCEKDYPCSCISGFT-EKNCEKAIDH 411
            N  C      Y C C  GFT   N ++ +D+
Sbjct: 2304 NGRCLNTRGSYTCECNDGFTASPNQDECLDN 2334



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 69/325 (21%), Positives = 107/325 (32%), Gaps = 74/325 (22%)

Query: 174  CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPF----SGKYCQELDACSFKPCKNNGSCI 229
            CQE      C G GKC++   S  + C C   +      + C +++ C        G+C 
Sbjct: 1610 CQELPG--LCQG-GKCINTFGS--FQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCY 1664

Query: 230  NKRENWDEQAYECVCHPPFT----GKNCSEIIGQ------------CQPHVCFH------ 267
            N   N     Y C+C P +     G NC ++               C   + F+      
Sbjct: 1665 NTVGN-----YTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMC 1719

Query: 268  --------------GNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLL-------FWKR 306
                            C   +++ F   C  Q  G   ++     V +          + 
Sbjct: 1720 CCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCEN 1779

Query: 307  GICPNSSSAYTYECPKGSSSQNGET---DVSEFSLVP-CQNGTDCIKISNDVMCICSP-- 360
            G+C N   ++  ECP G    +      D+ E    P CQ   +CI  +    C C P  
Sbjct: 1780 GVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGY 1839

Query: 361  IFTDLLCKSIQTSCESFP-LRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSIN- 418
             FT     + +  C+  P + ++  C      + C C +GF   +     D    L IN 
Sbjct: 1840 RFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTND-----DQTMCLDINE 1894

Query: 419  ----CLNEEWCFNIIGRFKYVCIPG 439
                      C N IG F   C  G
Sbjct: 1895 CERDACGNGTCRNTIGSFNCRCNHG 1919



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 71/306 (23%), Positives = 111/306 (36%), Gaps = 62/306 (20%)

Query: 178  LSSEFCSGHGKCLSEAWSKTYSCHCQPPF----SGKYCQELDACSFKPCKNNGSCINKRE 233
            L+S  C  +G+C +   S  + C C   F      K C+++D C   PC N G C N   
Sbjct: 771  LNSLLCD-NGQCRNTPGS--FVCTCPKGFIYKPDLKTCEDIDECESSPCIN-GVCKNSPG 826

Query: 234  NWD-EQAYECVCHPPFTGKNCSEII----------GQCQPHV--------CFHGNCSNIT 274
            ++  E + E    P  T   C E I          G+C+ ++        C     +   
Sbjct: 827  SFICECSSESTLDP--TKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWG 884

Query: 275  SNSFICECDEQFSGPFCEVSAKPCVSL----LF---WKRGICPNSSSAYTYECPKGSSSQ 327
            S   +C+ D      +  +    C  +    +F    K G+C N+  ++  +CP G +  
Sbjct: 885  SPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLD 944

Query: 328  NGETDVSEFSLVPC---QNGTDCIKISNDVMCICSPIFTDLLCKSIQTS-----CESFPL 379
                   +  L  C       +C       + I      D  C S+  +     CE  P+
Sbjct: 945  ATGRICLDIRLETCFLRYEDEEC------TLPIAGRHRMDACCCSVGAAWGTEECEECPM 998

Query: 380  RNNATCKKCEKDYPCSCISGFTEKNCE------KAIDHCKLLSINCLNEEWCFNIIGRFK 433
            RN       E +  C    GF  K         K I+ CK++   C + + C N IG FK
Sbjct: 999  RNTP-----EYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGK-CRNTIGSFK 1052

Query: 434  YVCIPG 439
              C  G
Sbjct: 1053 CRCDSG 1058



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 57/259 (22%), Positives = 83/259 (32%), Gaps = 73/259 (28%)

Query: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRE 233
           C+ S    FCS    C   +     SC  +          +  C+ + C N GSC +   
Sbjct: 85  CRHSCGDGFCSRPNMCTCPSGQIAPSCGSR---------SIQHCNIR-CMNGGSCSDDH- 133

Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEV 293
                   C+C   + G +C + +  C+      G C  +  N   C C   F+GP CE 
Sbjct: 134 --------CLCQKGYIGTHCGQPV--CESGCLNGGRC--VAPNR--CACTYGFTGPQCER 179

Query: 294 SAK--PCVSLLF-------------WKRGICPNSSSAYTYECPKGSSSQN---------- 328
             +  PC +++               K   C     A+ + C    +  +          
Sbjct: 180 DYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNI 239

Query: 329 ---GETDVSEFSLVP--CQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNA 383
                 DV E   +P  CQ G +CI       C C P    L                N 
Sbjct: 240 RTGACQDVDECQAIPGLCQGG-NCINTVGSFECKC-PAGHKL----------------NE 281

Query: 384 TCKKCEKDYPCSCISGFTE 402
             +KCE    CS I G  E
Sbjct: 282 VSQKCEDIDECSTIPGICE 300



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 43/182 (23%), Positives = 63/182 (34%), Gaps = 40/182 (21%)

Query: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-------LDACSFKPCKNNG 226
           C + +    C   G+C++        C C   F+G  C+            S + C+   
Sbjct: 145 CGQPVCESGCLNGGRCVAPN-----RCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQL 199

Query: 227 S---------CINKRENWDEQAYECVCHP--------PFTGKNCSEIIGQCQ--PHVCFH 267
           S         C      W      C   P        P       + + +CQ  P +C  
Sbjct: 200 SGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQG 259

Query: 268 GNCSNITSNSFICECDEQFSGPFCEVSAK-----PCVSLL-FWKRGICPNSSSAYTYECP 321
           GNC N T  SF C+C         EVS K      C ++    + G C N+ S+Y  +CP
Sbjct: 260 GNCIN-TVGSFECKCPAGHK--LNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCP 316

Query: 322 KG 323
            G
Sbjct: 317 PG 318



 Score = 36.2 bits (82), Expect = 0.087
 Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 10/88 (11%)

Query: 320 CPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPL 379
           CP G  + +  +   +   + C NG  C    +D  C+C   +    C   Q  CES  L
Sbjct: 102 CPSGQIAPSCGSRSIQHCNIRCMNGGSC----SDDHCLCQKGYIGTHCG--QPVCESGCL 155

Query: 380 RNNATCKKCEKDYPCSCISGFTEKNCEK 407
                  +C     C+C  GFT   CE+
Sbjct: 156 NGG----RCVAPNRCACTYGFTGPQCER 179



 Score = 33.5 bits (75), Expect = 0.57
 Identities = 42/209 (20%), Positives = 65/209 (31%), Gaps = 39/209 (18%)

Query: 259 QCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTY 318
           QC   +C H       S   +C C      P C   +    ++     G C +       
Sbjct: 79  QCIVPICRHSCGDGFCSRPNMCTCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDDHCL--- 135

Query: 319 ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFP 378
            C KG    +    V E     C NG  C+  +    C C+  FT   C+    +   F 
Sbjct: 136 -CQKGYIGTHCGQPVCESG---CLNGGRCVAPNR---CACTYGFTGPQCERDYRTGPCFT 188

Query: 379 LRNNATCK------KCEKDYPCSCISGFTEKNCE----------------------KAID 410
           + +N  C+       C K   C+ +       CE                      + +D
Sbjct: 189 VISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVD 248

Query: 411 HCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
            C+ +   C     C N +G F+  C  G
Sbjct: 249 ECQAIPGLCQGGN-CINTVGSFECKCPAG 276


>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
          Length = 383

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 64/243 (26%), Positives = 92/243 (37%), Gaps = 28/243 (11%)

Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENW 235
           + + ++ CS H        +   SC C P + G +C+    C   P   +G+C       
Sbjct: 22  QPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCER---CVRMPGCQHGTC------- 71

Query: 236 DEQAYECVCHPPFTGKNCSEIIGQCQPHVCFH-------GNCSNITSNSFICECDEQFSG 288
             Q ++C+CH  + GK C +       H+C         G C       + C C   F G
Sbjct: 72  -HQPWQCICHSGWAGKFCDK-----DEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHG 125

Query: 289 PFCEVSAKPCVSLLFWKR--GICPNSSSA---YTYECPKGSSSQNGETDVSEFSLVPCQN 343
             CE  A PC       R  G C +       +T  C  G      E +V +  + PC N
Sbjct: 126 RDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCAN 185

Query: 344 GTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEK 403
           G  C+   N   C+C   F    C      C S P +  A C+    D+ C C SG+  K
Sbjct: 186 GATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGK 245

Query: 404 NCE 406
            CE
Sbjct: 246 TCE 248



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 50/202 (24%), Positives = 85/202 (42%), Gaps = 11/202 (5%)

Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELD--ACSFKPCKNNGSCINKRE 233
           E L  E C     C      + + C C   ++GK+C + +    +  PC+N G C+    
Sbjct: 53  EGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112

Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQP--HVCFHGN-CSNIT--SNSFICECDEQFSG 288
                 Y CVC P F G++C    G C+     C +G  C +    + +F C C   F G
Sbjct: 113 G----EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVG 168

Query: 289 PFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI 348
             CEV+   C+         C +  + ++  CP+G + +    ++ + +  PCQ G  C 
Sbjct: 169 ARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR 228

Query: 349 KISNDVMCICSPIFTDLLCKSI 370
              +D  C+C   +    C+ +
Sbjct: 229 DRVHDFDCLCPSGYGGKTCELV 250



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 66/244 (27%), Positives = 88/244 (36%), Gaps = 52/244 (21%)

Query: 353 DVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHC 412
           D  C C P +  L C+     C   P   + TC    + + C C SG+  K C+K    C
Sbjct: 43  DGSCRCDPGWEGLHCER----CVRMPGCQHGTC---HQPWQCICHSGWAGKFCDKDEHIC 95

Query: 413 KLLSINCLNEEWC-FNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGI-CQ 470
              S  C N   C ++  G +  VC+PG                         FHG  C+
Sbjct: 96  TTQS-PCQNGGQCMYDGGGEYHCVCLPG-------------------------FHGRDCE 129

Query: 471 DK-GPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDP-EDNNSSCWFPH 528
            K GP +     Q G     G +CQ   D  F L   C     +V    E N   C    
Sbjct: 130 RKAGPCE-----QAGSPCRNGGQCQD--DQGFALNFTCRCLVGFVGARCEVNVDDCLM-- 180

Query: 529 EGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRP 588
                 CANG +CL  +    +  LC   +AG     N  D     CQ  A C+D ++  
Sbjct: 181 ----RPCANGATCL--DGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDF 234

Query: 589 RYLC 592
             LC
Sbjct: 235 DCLC 238



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 8/76 (10%)

Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
           C+    CL       +SC C   F+G++C   LD C+ +PC+    C ++  ++D     
Sbjct: 183 CANGATCLDGI--NRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFD----- 235

Query: 242 CVCHPPFTGKNCSEII 257
           C+C   + GK C  ++
Sbjct: 236 CLCPSGYGGKTCELVL 251


>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
          Length = 383

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 64/243 (26%), Positives = 92/243 (37%), Gaps = 28/243 (11%)

Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENW 235
           + + ++ CS H        +   SC C P + G +C+    C   P   +G+C       
Sbjct: 22  QPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCER---CVRMPGCQHGTC------- 71

Query: 236 DEQAYECVCHPPFTGKNCSEIIGQCQPHVCFH-------GNCSNITSNSFICECDEQFSG 288
             Q ++C+CH  + GK C +       H+C         G C       + C C   F G
Sbjct: 72  -HQPWQCICHSGWAGKFCDK-----DEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHG 125

Query: 289 PFCEVSAKPCVSLLFWKR--GICPNSSSA---YTYECPKGSSSQNGETDVSEFSLVPCQN 343
             CE  A PC       R  G C +       +T  C  G      E +V +  + PC N
Sbjct: 126 RDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCAN 185

Query: 344 GTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEK 403
           G  C+   N   C+C   F    C      C S P +  A C+    D+ C C SG+  K
Sbjct: 186 GATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGK 245

Query: 404 NCE 406
            CE
Sbjct: 246 TCE 248



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 50/202 (24%), Positives = 85/202 (42%), Gaps = 11/202 (5%)

Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELD--ACSFKPCKNNGSCINKRE 233
           E L  E C     C      + + C C   ++GK+C + +    +  PC+N G C+    
Sbjct: 53  EGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112

Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQP--HVCFHGN-CSNIT--SNSFICECDEQFSG 288
                 Y CVC P F G++C    G C+     C +G  C +    + +F C C   F G
Sbjct: 113 G----EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVG 168

Query: 289 PFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI 348
             CEV+   C+         C +  + ++  CP+G + +    ++ + +  PCQ G  C 
Sbjct: 169 ARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR 228

Query: 349 KISNDVMCICSPIFTDLLCKSI 370
              +D  C+C   +    C+ +
Sbjct: 229 DRVHDFDCLCPSGYGGKTCELV 250



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 66/244 (27%), Positives = 88/244 (36%), Gaps = 52/244 (21%)

Query: 353 DVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHC 412
           D  C C P +  L C+     C   P   + TC    + + C C SG+  K C+K    C
Sbjct: 43  DGSCRCDPGWEGLHCER----CVRMPGCQHGTC---HQPWQCICHSGWAGKFCDKDEHIC 95

Query: 413 KLLSINCLNEEWC-FNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGI-CQ 470
              S  C N   C ++  G +  VC+PG                         FHG  C+
Sbjct: 96  TTQS-PCQNGGQCMYDGGGEYHCVCLPG-------------------------FHGRDCE 129

Query: 471 DK-GPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDP-EDNNSSCWFPH 528
            K GP +     Q G     G +CQ   D  F L   C     +V    E N   C    
Sbjct: 130 RKAGPCE-----QAGSPCRNGGQCQD--DQGFALNFTCRCLVGFVGARCEVNVDDCLM-- 180

Query: 529 EGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRP 588
                 CANG +CL  +    +  LC   +AG     N  D     CQ  A C+D ++  
Sbjct: 181 ----RPCANGATCL--DGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDF 234

Query: 589 RYLC 592
             LC
Sbjct: 235 DCLC 238



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 8/76 (10%)

Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
           C+    CL       +SC C   F+G++C   LD C+ +PC+    C ++  ++D     
Sbjct: 183 CANGATCLDGI--NRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFD----- 235

Query: 242 CVCHPPFTGKNCSEII 257
           C+C   + GK C  ++
Sbjct: 236 CLCPSGYGGKTCELVL 251


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 76/282 (26%), Positives = 116/282 (41%), Gaps = 30/282 (10%)

Query: 176  ESLSSEFCSGHGKCLSEAWSKTYSCH---CQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
            E L    C+ +G C +   S   SCH    + P   K+C+++D C       NG C N  
Sbjct: 1042 ECLEPNVCA-NGDCSNLEGSYMCSCHKGYTRTP-DHKHCRDIDECQQGNLCVNGQCKN-- 1097

Query: 233  ENWDEQAYECVCHPPF---TGKNCSEIIGQCQ-PHVCFHGNCSNITSNSFICECDEQFS- 287
                E ++ C C   +     K+  E I +CQ  H+C HG C N T  SF C CD+ +  
Sbjct: 1098 ---TEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRN-TEGSFQCVCDQGYRA 1153

Query: 288  ---GPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGET--DVSEFSLVP-C 341
               G  CE   +        +RG C N++ +Y   CP G    + +T  D++E      C
Sbjct: 1154 SGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLC 1213

Query: 342  QNGTDCIKISNDVMCICSPIFT----DLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCI 397
                +C+       C+C   F+       C+ I     +    ++  C      + C C 
Sbjct: 1214 GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCY 1273

Query: 398  SGFTEKNCEKA---IDHCKLLSINCLNEEWCFNIIGRFKYVC 436
             GF      +    ++ C+LLS  C  E +C N+ G F  VC
Sbjct: 1274 QGFQAPQDGQGCVDVNECELLSGVC-GEAFCENVEGSFLCVC 1314



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 100/395 (25%), Positives = 150/395 (37%), Gaps = 81/395 (20%)

Query: 213  ELDACSFKP--CKNNGSCINKRENWDEQAYECVCHPPFT----GKNCSEIIGQCQ-PHVC 265
            E++ C+  P  C   G CIN         Y C+C+  +      + C +I    Q  H+C
Sbjct: 874  EINECTVNPDIC-GAGHCINLPVR-----YTCICYEGYRFSEQQRKCVDIDECTQVQHLC 927

Query: 266  FHGNCSNITSNSFICECDEQF----SGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYE-C 320
              G C N T  SF+C C   F     G  C +    C+       G C N+  A+  E C
Sbjct: 928  SQGRCEN-TEGSFLCICPAGFMASEEGTNC-IDVDECLRPDVCGEGHCVNTVGAFRCEYC 985

Query: 321  PKG-SSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCI-CSPIFTDLLCKSIQTS-CE 375
              G   +Q G  +  +  L P  C +   C+       C+ C+  F     + +    C 
Sbjct: 986  DSGYRMTQRGRCEDIDECLNPSTCPD-EQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECL 1044

Query: 376  SFPLRNNATCKKCEKDYPCSCISGFT----EKNCEKAIDHCKLLSINCLNEEWCFNIIGR 431
               +  N  C   E  Y CSC  G+T     K+C + ID C+  ++ C+N + C N  G 
Sbjct: 1045 EPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHC-RDIDECQQGNL-CVNGQ-CKNTEGS 1101

Query: 432  FKYVCIPG----CTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGF-A 486
            F+  C  G      K+ C  +      H+HLC      HG C++     F+ V   G+ A
Sbjct: 1102 FRCTCGQGYQLSAAKDQCEDIDECQ--HRHLC-----AHGQCRNT-EGSFQCVCDQGYRA 1153

Query: 487  GSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEED 546
               G+ C+ + +        C ED                     K +C  G  C++   
Sbjct: 1154 SGLGDHCEDINE--------CLED---------------------KSVCQRG-DCINTAG 1183

Query: 547  SQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVC 581
            S  Y   C     G    +N T    NEC+H  +C
Sbjct: 1184 S--YDCTC---PDGFQLDDNKTCQDINECEHPGLC 1213



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 74/311 (23%), Positives = 104/311 (33%), Gaps = 56/311 (18%)

Query: 176  ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFS---GKYCQELDACSFKP-CKNNGSCINK 231
            E L  +     G C++ A S  Y C C   F     K CQ+++ C     C   G C+N 
Sbjct: 1165 ECLEDKSVCQRGDCINTAGS--YDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNT 1222

Query: 232  RENWDEQAYECVCHPPFT----GKNCSEIIGQCQPHVC-FHGNCSNITSNSFICECDEQF 286
                 E ++ CVC   F+    G+ C +I       VC  HG C N T+ SF C C + F
Sbjct: 1223 -----EGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDN-TAGSFRCLCYQGF 1276

Query: 287  SGP----------FCEVSAKPCVSLLFWKRGICPNSSSAYTYECP---------KGSSSQ 327
              P           CE+ +  C          C N   ++   C           G    
Sbjct: 1277 QAPQDGQGCVDVNECELLSGVC------GEAFCENVEGSFLCVCADENQEYSPMTGQCRS 1330

Query: 328  NGETDVSEFSLVPCQNGTDCIKISNDV-MC--ICSPIFTDLLCKSIQ-----TSCESFPL 379
               TD+      P +   +C    ND  +C  + +P  T   C          +CE FP 
Sbjct: 1331 RTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPC 1390

Query: 380  RNNAT------CKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFK 433
                T      C K +   P    S        K  D C L         +C N    ++
Sbjct: 1391 PVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYE 1450

Query: 434  YVCIPGCTKNP 444
              C  G   +P
Sbjct: 1451 CYCKQGTYYDP 1461



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 40/148 (27%), Positives = 65/148 (43%), Gaps = 20/148 (13%)

Query: 149  ITVMASGPSPCPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFS- 207
            I    S    CP G +L+     Q   E      C   G+CL+   S  + C CQ  FS 
Sbjct: 1179 INTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGS--FHCVCQQGFSI 1236

Query: 208  ---GKYCQELDAC-SFKPCKNNGSCINKRENWDEQAYECVCH----PPFTGKNCSEIIGQ 259
               G+ C+++D C +   C ++G C N        ++ C+C+     P  G+ C + + +
Sbjct: 1237 SADGRTCEDIDECVNNTVCDSHGFCDN-----TAGSFRCLCYQGFQAPQDGQGCVD-VNE 1290

Query: 260  CQ--PHVCFHGNCSNITSNSFICECDEQ 285
            C+    VC    C N+   SF+C C ++
Sbjct: 1291 CELLSGVCGEAFCENV-EGSFLCVCADE 1317



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 62/290 (21%), Positives = 99/290 (34%), Gaps = 59/290 (20%)

Query: 181  EFCSGHGKCLSEAWSKTYSCHCQPPFSGKY-------CQELDACSFKPCKNNGSCINKRE 233
            E C  +G CL+      Y C+C+    G Y       C ++D C       +G C+N   
Sbjct: 1435 EICK-NGFCLNTR--PGYECYCK---QGTYYDPVKLQCFDMDECQDPSSCIDGQCVNT-- 1486

Query: 234  NWDEQAYECVCHPPF----TGKNC---SEIIGQCQPHVCFHGNCSNITSNSFICECDEQF 286
               E +Y C C  P     + K C   +E   Q +    +   C    S+ ++C      
Sbjct: 1487 ---EGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVC------ 1537

Query: 287  SGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQN--- 343
                    ++P V         C     A+  +C           D ++   +P      
Sbjct: 1538 --------SRPLVGKQTTYTECCCLYGEAWGMQC--ALCPLKDSDDYAQLCNIPVTGRRQ 1587

Query: 344  --GTDC-IKISNDVMCICSPIFTD--LLCKSIQTSCESFPLRN---NATCKKCEKDYPCS 395
              G D  +  S        P F     L    +   E   + N   N  C + ++ Y C 
Sbjct: 1588 PYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCD 1647

Query: 396  CISGF---TEKNCEKAIDHCKLLSIN---CLNEEWCFNIIGRFKYVCIPG 439
            C  G+   T K     ++ C  L+     C N + C N  G +K +C+PG
Sbjct: 1648 CFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAK-CINTDGSYKCLCLPG 1696



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 39/165 (23%), Positives = 62/165 (37%), Gaps = 35/165 (21%)

Query: 170 KQQFCQESLSSEFCSGHGKCLSEAWSKTYSCH-----CQPPF---SGKYCQELDACSFKP 221
           KQ+ C  ++ + +  G  KC       +Y  +     C P +   +  +CQ+++ C  + 
Sbjct: 577 KQEDCCGTVGTSW--GFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQG 634

Query: 222 CKNNGSCINKRENWDEQAYECVCH----PPFTGKNC-------SEIIGQCQPHV-----C 265
              NG C+N        +Y C C     P  T  +C       SE  G C   V     C
Sbjct: 635 VCPNGECLNTM-----GSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQC 689

Query: 266 FHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICP 310
            H    ++T     C   + + GP CE    P  +     + ICP
Sbjct: 690 MHPLSVHLTKQLCCCSVGKAW-GPHCEKCPLPGTAAF---KEICP 730



 Score = 32.7 bits (73), Expect = 0.97
 Identities = 34/116 (29%), Positives = 41/116 (35%), Gaps = 27/116 (23%)

Query: 162 GLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTY-SCHCQPPFSGKYCQELDACSFK 220
           G RL V  KQQ    ++    C  HG      WSK   S  C  P          +C   
Sbjct: 152 GSRLQVHQKQQLQGVNVCGGRCC-HG------WSKAPGSQRCTKP----------SC-VP 193

Query: 221 PCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSN 276
           PC+N G C+  +         CVC P   GK C  I  Q      F G      S+
Sbjct: 194 PCQNGGMCLRPQL--------CVCKPGTKGKACETIAAQDTSSPVFGGQSPGAASS 241



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 19/61 (31%), Positives = 28/61 (45%), Gaps = 4/61 (6%)

Query: 320 CPKGSSSQNGETDVSEFSLVP-CQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFP 378
           C  G S   G    ++ S VP CQNG  C++     +C+C P      C++I     S P
Sbjct: 173 CCHGWSKAPGSQRCTKPSCVPPCQNGGMCLR---PQLCVCKPGTKGKACETIAAQDTSSP 229

Query: 379 L 379
           +
Sbjct: 230 V 230



 Score = 29.6 bits (65), Expect = 8.2
 Identities = 17/53 (32%), Positives = 23/53 (43%), Gaps = 14/53 (26%)

Query: 207 SGKYCQELDACSFK------PCKNNGSCINKRENWDEQAYECVCHPPFTGKNC 253
           +G     L A +F+      PC N G C ++ +        C C P FTGK C
Sbjct: 386 NGHAADTLTATNFRVVICHLPCMNGGQCSSRDK--------CQCPPNFTGKLC 430


>gi|46249412 latent transforming growth factor beta binding protein
           1 isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 76/282 (26%), Positives = 116/282 (41%), Gaps = 30/282 (10%)

Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCH---CQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
           E L    C+ +G C +   S   SCH    + P   K+C+++D C       NG C N  
Sbjct: 716 ECLEPNVCA-NGDCSNLEGSYMCSCHKGYTRTP-DHKHCRDIDECQQGNLCVNGQCKN-- 771

Query: 233 ENWDEQAYECVCHPPF---TGKNCSEIIGQCQ-PHVCFHGNCSNITSNSFICECDEQFS- 287
               E ++ C C   +     K+  E I +CQ  H+C HG C N T  SF C CD+ +  
Sbjct: 772 ---TEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRN-TEGSFQCVCDQGYRA 827

Query: 288 ---GPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGET--DVSEFSLVP-C 341
              G  CE   +        +RG C N++ +Y   CP G    + +T  D++E      C
Sbjct: 828 SGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLC 887

Query: 342 QNGTDCIKISNDVMCICSPIFT----DLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCI 397
               +C+       C+C   F+       C+ I     +    ++  C      + C C 
Sbjct: 888 GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCY 947

Query: 398 SGFTEKNCEKA---IDHCKLLSINCLNEEWCFNIIGRFKYVC 436
            GF      +    ++ C+LLS  C  E +C N+ G F  VC
Sbjct: 948 QGFQAPQDGQGCVDVNECELLSGVC-GEAFCENVEGSFLCVC 988



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 100/395 (25%), Positives = 150/395 (37%), Gaps = 81/395 (20%)

Query: 213 ELDACSFKP--CKNNGSCINKRENWDEQAYECVCHPPFT----GKNCSEIIGQCQ-PHVC 265
           E++ C+  P  C   G CIN         Y C+C+  +      + C +I    Q  H+C
Sbjct: 548 EINECTVNPDIC-GAGHCINLPVR-----YTCICYEGYRFSEQQRKCVDIDECTQVQHLC 601

Query: 266 FHGNCSNITSNSFICECDEQF----SGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYE-C 320
             G C N T  SF+C C   F     G  C +    C+       G C N+  A+  E C
Sbjct: 602 SQGRCEN-TEGSFLCICPAGFMASEEGTNC-IDVDECLRPDVCGEGHCVNTVGAFRCEYC 659

Query: 321 PKG-SSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCI-CSPIFTDLLCKSIQTS-CE 375
             G   +Q G  +  +  L P  C +   C+       C+ C+  F     + +    C 
Sbjct: 660 DSGYRMTQRGRCEDIDECLNPSTCPD-EQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECL 718

Query: 376 SFPLRNNATCKKCEKDYPCSCISGFT----EKNCEKAIDHCKLLSINCLNEEWCFNIIGR 431
              +  N  C   E  Y CSC  G+T     K+C + ID C+  ++ C+N + C N  G 
Sbjct: 719 EPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHC-RDIDECQQGNL-CVNGQ-CKNTEGS 775

Query: 432 FKYVCIPG----CTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGF-A 486
           F+  C  G      K+ C  +      H+HLC      HG C++     F+ V   G+ A
Sbjct: 776 FRCTCGQGYQLSAAKDQCEDIDECQ--HRHLC-----AHGQCRNT-EGSFQCVCDQGYRA 827

Query: 487 GSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEED 546
              G+ C+ + +        C ED                     K +C  G  C++   
Sbjct: 828 SGLGDHCEDINE--------CLED---------------------KSVCQRG-DCINTAG 857

Query: 547 SQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVC 581
           S  Y   C     G    +N T    NEC+H  +C
Sbjct: 858 S--YDCTC---PDGFQLDDNKTCQDINECEHPGLC 887



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 74/311 (23%), Positives = 104/311 (33%), Gaps = 56/311 (18%)

Query: 176  ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFS---GKYCQELDACSFKP-CKNNGSCINK 231
            E L  +     G C++ A S  Y C C   F     K CQ+++ C     C   G C+N 
Sbjct: 839  ECLEDKSVCQRGDCINTAGS--YDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNT 896

Query: 232  RENWDEQAYECVCHPPFT----GKNCSEIIGQCQPHVC-FHGNCSNITSNSFICECDEQF 286
                 E ++ CVC   F+    G+ C +I       VC  HG C N T+ SF C C + F
Sbjct: 897  -----EGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDN-TAGSFRCLCYQGF 950

Query: 287  SGP----------FCEVSAKPCVSLLFWKRGICPNSSSAYTYECP---------KGSSSQ 327
              P           CE+ +  C          C N   ++   C           G    
Sbjct: 951  QAPQDGQGCVDVNECELLSGVC------GEAFCENVEGSFLCVCADENQEYSPMTGQCRS 1004

Query: 328  NGETDVSEFSLVPCQNGTDCIKISNDV-MC--ICSPIFTDLLCKSIQ-----TSCESFPL 379
               TD+      P +   +C    ND  +C  + +P  T   C          +CE FP 
Sbjct: 1005 RTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPC 1064

Query: 380  RNNAT------CKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFK 433
                T      C K +   P    S        K  D C L         +C N    ++
Sbjct: 1065 PVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYE 1124

Query: 434  YVCIPGCTKNP 444
              C  G   +P
Sbjct: 1125 CYCKQGTYYDP 1135



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 40/148 (27%), Positives = 65/148 (43%), Gaps = 20/148 (13%)

Query: 149 ITVMASGPSPCPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFS- 207
           I    S    CP G +L+     Q   E      C   G+CL+   S  + C CQ  FS 
Sbjct: 853 INTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGS--FHCVCQQGFSI 910

Query: 208 ---GKYCQELDAC-SFKPCKNNGSCINKRENWDEQAYECVCH----PPFTGKNCSEIIGQ 259
              G+ C+++D C +   C ++G C N        ++ C+C+     P  G+ C + + +
Sbjct: 911 SADGRTCEDIDECVNNTVCDSHGFCDN-----TAGSFRCLCYQGFQAPQDGQGCVD-VNE 964

Query: 260 CQ--PHVCFHGNCSNITSNSFICECDEQ 285
           C+    VC    C N+   SF+C C ++
Sbjct: 965 CELLSGVCGEAFCENV-EGSFLCVCADE 991



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 62/290 (21%), Positives = 99/290 (34%), Gaps = 59/290 (20%)

Query: 181  EFCSGHGKCLSEAWSKTYSCHCQPPFSGKY-------CQELDACSFKPCKNNGSCINKRE 233
            E C  +G CL+      Y C+C+    G Y       C ++D C       +G C+N   
Sbjct: 1109 EICK-NGFCLNTR--PGYECYCK---QGTYYDPVKLQCFDMDECQDPSSCIDGQCVNT-- 1160

Query: 234  NWDEQAYECVCHPPF----TGKNC---SEIIGQCQPHVCFHGNCSNITSNSFICECDEQF 286
               E +Y C C  P     + K C   +E   Q +    +   C    S+ ++C      
Sbjct: 1161 ---EGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVC------ 1211

Query: 287  SGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQN--- 343
                    ++P V         C     A+  +C           D ++   +P      
Sbjct: 1212 --------SRPLVGKQTTYTECCCLYGEAWGMQC--ALCPLKDSDDYAQLCNIPVTGRRQ 1261

Query: 344  --GTDC-IKISNDVMCICSPIFTD--LLCKSIQTSCESFPLRN---NATCKKCEKDYPCS 395
              G D  +  S        P F     L    +   E   + N   N  C + ++ Y C 
Sbjct: 1262 PYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCD 1321

Query: 396  CISGF---TEKNCEKAIDHCKLLSIN---CLNEEWCFNIIGRFKYVCIPG 439
            C  G+   T K     ++ C  L+     C N + C N  G +K +C+PG
Sbjct: 1322 CFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAK-CINTDGSYKCLCLPG 1370



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 39/165 (23%), Positives = 62/165 (37%), Gaps = 35/165 (21%)

Query: 170 KQQFCQESLSSEFCSGHGKCLSEAWSKTYSCH-----CQPPF---SGKYCQELDACSFKP 221
           KQ+ C  ++ + +  G  KC       +Y  +     C P +   +  +CQ+++ C  + 
Sbjct: 251 KQEDCCGTVGTSW--GFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQG 308

Query: 222 CKNNGSCINKRENWDEQAYECVCH----PPFTGKNC-------SEIIGQCQPHV-----C 265
              NG C+N        +Y C C     P  T  +C       SE  G C   V     C
Sbjct: 309 VCPNGECLNTM-----GSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQC 363

Query: 266 FHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICP 310
            H    ++T     C   + + GP CE    P  +     + ICP
Sbjct: 364 MHPLSVHLTKQLCCCSVGKAW-GPHCEKCPLPGTAAF---KEICP 404



 Score = 29.6 bits (65), Expect = 8.2
 Identities = 17/53 (32%), Positives = 23/53 (43%), Gaps = 14/53 (26%)

Query: 207 SGKYCQELDACSFK------PCKNNGSCINKRENWDEQAYECVCHPPFTGKNC 253
           +G     L A +F+      PC N G C ++ +        C C P FTGK C
Sbjct: 60  NGHAADTLTATNFRVVICHLPCMNGGQCSSRDK--------CQCPPNFTGKLC 104


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 50/192 (26%), Positives = 79/192 (41%), Gaps = 21/192 (10%)

Query: 215  DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNIT 274
            D+C   PC+N GSC+ +           V     + ++   II   +P            
Sbjct: 3804 DSCVHGPCQNGGSCLRRL---------AVSSVLKSRESLPVIIVANEP------------ 3842

Query: 275  SNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVS 334
               F+C+C   ++G +CE+    C+       G C N    ++  CP G + +  E D++
Sbjct: 3843 LQPFLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDIN 3902

Query: 335  EFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPC 394
            E    PC+NG  C        C+C   +T  +C+S    CE  P  N  +C+     Y C
Sbjct: 3903 ECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYC 3962

Query: 395  SCISGFTEKNCE 406
             C  G   K+CE
Sbjct: 3963 HCPFGVFGKHCE 3974



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 37/127 (29%), Positives = 55/127 (43%), Gaps = 6/127 (4%)

Query: 198  YSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
            + C C P ++G +C+ ++D C   PC + G+C N         + C C   FTG+ C   
Sbjct: 3846 FLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNL-----VGGFSCSCPDGFTGRACERD 3900

Query: 257  IGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAY 316
            I +C    C +G        SF C C   ++G  CE S   C     +  G C +   +Y
Sbjct: 3901 INECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSY 3960

Query: 317  TYECPKG 323
               CP G
Sbjct: 3961 YCHCPFG 3967



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 7/121 (5%)

Query: 198  YSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
            +SC C   F+G+ C+ +++ C   PCKN   C N        ++ CVC   +TGK C   
Sbjct: 3884 FSCSCPDGFTGRACERDINECLQSPCKNGAICQNF-----PGSFNCVCKTGYTGKMCESS 3938

Query: 257  IGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWK-RGICPNSSSA 315
            +  C+ + CF+G       +S+ C C     G  CE+++     L + +   + PN++  
Sbjct: 3939 VNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCELNSYGFEELSYMEFPSLDPNNNYI 3998

Query: 316  Y 316
            Y
Sbjct: 3999 Y 3999



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 42/150 (28%), Positives = 56/150 (37%), Gaps = 31/150 (20%)

Query: 340  PCQNGTDCIK------------------ISND----VMCICSPIFTDLLCKSIQTSCESF 377
            PCQNG  C++                  ++N+     +C C P +    C+     C   
Sbjct: 3810 PCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDECLPS 3869

Query: 378  PLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCI 437
            P  +  TC      + CSC  GFT + CE+ I+ C  L   C N   C N  G F  VC 
Sbjct: 3870 PCHSGGTCHNLVGGFSCSCPDGFTGRACERDINEC--LQSPCKNGAICQNFPGSFNCVCK 3927

Query: 438  PGCTKNPCWFLKNVYLIHQHLCYCGVTFHG 467
             G T   C    N        C C   F+G
Sbjct: 3928 TGYTGKMCESSVN-------YCECNPCFNG 3950



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 27/95 (28%), Positives = 43/95 (45%)

Query: 319  ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFP 378
            +C  G +    E D+ E    PC +G  C  +     C C   FT   C+     C   P
Sbjct: 3849 KCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSP 3908

Query: 379  LRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCK 413
             +N A C+     + C C +G+T K CE ++++C+
Sbjct: 3909 CKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCE 3943



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 40/148 (27%), Positives = 59/148 (39%), Gaps = 38/148 (25%)

Query: 184  SGHGKCLSEAWSKTYSCHCQPPFSGKY---------------CQELDACSFKPCKNNGSC 228
            +G   C++  W    S     PFSGK+               C+  + C+  PC  +  C
Sbjct: 4360 AGFDGCIASMWYGGESL----PFSGKHSLASISKTDPSVKIGCRGPNICASNPCWGDLLC 4415

Query: 229  INKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHG-NCSNITSNSFICECDEQFS 287
            IN+   W   AY CV  PP          G C  H C +G +C     + F C C +  +
Sbjct: 4416 INQ---W--YAYRCV--PP----------GDCASHPCQNGGSCEPGLHSGFTCSCPDSHT 4458

Query: 288  GPFCEVSAKPCVSLLFWKRGICPNSSSA 315
            G  CE+    C+ +L  +  +C   S A
Sbjct: 4459 GRTCEM-VVACLGVLCPQGKVCKAGSPA 4485



 Score = 38.5 bits (88), Expect = 0.018
 Identities = 19/60 (31%), Positives = 33/60 (55%), Gaps = 10/60 (16%)

Query: 197  TYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPF--TGKNC 253
            +++C C+  ++GK C+  ++ C   PC N GSC +  +++        CH PF   GK+C
Sbjct: 3921 SFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSY-------YCHCPFGVFGKHC 3973



 Score = 33.5 bits (75), Expect = 0.57
 Identities = 15/51 (29%), Positives = 23/51 (45%)

Query: 367  CKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSI 417
            C  ++ +C   P ++  TC        C C  G T K CEK++     LS+
Sbjct: 4159 CPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSL 4209



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 6/48 (12%)

Query: 211  CQELD-ACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEII 257
            C  L+ AC+  PC++ G+C+   + W  Q  +C C    TGK C + +
Sbjct: 4159 CPRLEGACTRSPCQHGGTCM---DYWSWQ--QCHCKEGLTGKYCEKSV 4201



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 17/64 (26%), Positives = 28/64 (43%), Gaps = 9/64 (14%)

Query: 355  MCICSPIFTDLLCKSIQTS--------CESFPLRNNATCKK-CEKDYPCSCISGFTEKNC 405
            +C  +P + DLLC +   +        C S P +N  +C+      + CSC    T + C
Sbjct: 4403 ICASNPCWGDLLCINQWYAYRCVPPGDCASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTC 4462

Query: 406  EKAI 409
            E  +
Sbjct: 4463 EMVV 4466



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 16/55 (29%), Positives = 22/55 (40%)

Query: 253  CSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRG 307
            C  + G C    C HG       +   C C E  +G +CE S  P  +L    +G
Sbjct: 4159 CPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSLEGKG 4213


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.466 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,777,009
Number of Sequences: 37866
Number of extensions: 1350294
Number of successful extensions: 6459
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 96
Number of HSP's successfully gapped in prelim test: 213
Number of HSP's that attempted gapping in prelim test: 2920
Number of HSP's gapped (non-prelim): 1516
length of query: 594
length of database: 18,247,518
effective HSP length: 108
effective length of query: 486
effective length of database: 14,157,990
effective search space: 6880783140
effective search space used: 6880783140
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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