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Search of human proteins with 37675283
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|37675283 adaptor-related protein complex 4, epsilon 1
subunit [Homo sapiens]
(1137 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit... 2236 0.0
gi|71772942 adaptor-related protein complex 1, gamma 1 subunit i... 238 3e-62
gi|71773010 adaptor-related protein complex 1, gamma 1 subunit i... 234 5e-61
gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [H... 216 1e-55
gi|19913414 adaptor-related protein complex 2, alpha 1 subunit i... 169 2e-41
gi|19913416 adaptor-related protein complex 2, alpha 1 subunit i... 169 2e-41
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ... 164 4e-40
gi|27477041 adaptor-related protein complex 2, alpha 2 subunit [... 164 6e-40
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ... 78 5e-14
gi|22027651 adaptor-related protein complex 1 beta 1 subunit iso... 67 1e-10
gi|22027653 adaptor-related protein complex 1 beta 1 subunit iso... 67 1e-10
gi|221316632 coatomer protein complex, subunit beta 1 [Homo sapi... 60 9e-09
gi|221316630 coatomer protein complex, subunit beta 1 [Homo sapi... 60 9e-09
gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens] 60 9e-09
gi|71773106 adaptor-related protein complex 2, beta 1 subunit is... 60 9e-09
gi|4557469 adaptor-related protein complex 2, beta 1 subunit iso... 60 9e-09
gi|32484979 adaptor-related protein complex 3, beta 1 subunit [H... 50 9e-06
gi|109134349 coatomer protein complex, subunit gamma 2 [Homo sap... 47 1e-04
gi|34482047 adaptor-related protein complex 3, beta 2 subunit [H... 45 5e-04
gi|11559929 coatomer protein complex, subunit gamma 1 [Homo sapi... 42 0.003
gi|19923599 calmin [Homo sapiens] 38 0.048
gi|19923479 suppressor of fused [Homo sapiens] 38 0.063
gi|171184451 centrosome-associated protein 350 [Homo sapiens] 35 0.31
gi|239754668 PREDICTED: mucin 12 [Homo sapiens] 35 0.41
gi|89026265 PREDICTED: mucin 12 [Homo sapiens] 35 0.41
gi|239743293 PREDICTED: mucin 12 [Homo sapiens] 35 0.41
gi|224593278 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Homo sap... 35 0.53
gi|23510381 transportin 1 isoform 2 [Homo sapiens] 33 1.2
gi|133925811 transportin 1 isoform 1 [Homo sapiens] 33 1.2
gi|7706254 NOP58 ribonucleoprotein homolog [Homo sapiens] 33 1.2
>gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit
[Homo sapiens]
Length = 1137
Score = 2236 bits (5795), Expect = 0.0
Identities = 1137/1137 (100%), Positives = 1137/1137 (100%)
Query: 1 MSDIVEKTLTALPGLFLQNQPGGGPAAAKASFSSRLGSLVRGITALTSKHEEEKLIQQEL 60
MSDIVEKTLTALPGLFLQNQPGGGPAAAKASFSSRLGSLVRGITALTSKHEEEKLIQQEL
Sbjct: 1 MSDIVEKTLTALPGLFLQNQPGGGPAAAKASFSSRLGSLVRGITALTSKHEEEKLIQQEL 60
Query: 61 SSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAV 120
SSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAV
Sbjct: 61 SSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAV 120
Query: 121 SLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQHS 180
SLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQHS
Sbjct: 121 SLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQHS 180
Query: 181 KEIVRRKAVLALYKFHLIAPNQVQHIHIKFRKALCDRDVGVMAASLHIYLRMIKENSSGY 240
KEIVRRKAVLALYKFHLIAPNQVQHIHIKFRKALCDRDVGVMAASLHIYLRMIKENSSGY
Sbjct: 181 KEIVRRKAVLALYKFHLIAPNQVQHIHIKFRKALCDRDVGVMAASLHIYLRMIKENSSGY 240
Query: 241 KDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLLGKDDQRTSELMYDVLD 300
KDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLLGKDDQRTSELMYDVLD
Sbjct: 241 KDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLLGKDDQRTSELMYDVLD 300
Query: 301 ESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKAL 360
ESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKAL
Sbjct: 301 ESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKAL 360
Query: 361 TYVIQQDPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQNITVIVQKMLEYLHQS 420
TYVIQQDPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQNITVIVQKMLEYLHQS
Sbjct: 361 TYVIQQDPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQNITVIVQKMLEYLHQS 420
Query: 421 KEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDD 480
KEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDD
Sbjct: 421 KEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDD 480
Query: 481 ETEDQQLRLYAVQSYLTLLDMENVFYPQRFLQVMSWVLGEYSYLLDKETPEEVIAKLYKL 540
ETEDQQLRLYAVQSYLTLLDMENVFYPQRFLQVMSWVLGEYSYLLDKETPEEVIAKLYKL
Sbjct: 481 ETEDQQLRLYAVQSYLTLLDMENVFYPQRFLQVMSWVLGEYSYLLDKETPEEVIAKLYKL 540
Query: 541 LMNDSVSSETKAWLIAAVTKLTSQAHSSNTVERLIHEFTISLDTCMRQHAFELKHLHENV 600
LMNDSVSSETKAWLIAAVTKLTSQAHSSNTVERLIHEFTISLDTCMRQHAFELKHLHENV
Sbjct: 541 LMNDSVSSETKAWLIAAVTKLTSQAHSSNTVERLIHEFTISLDTCMRQHAFELKHLHENV 600
Query: 601 ELMKSLLPVDRSCEDLVVDASLSFLDGFVAEGLSQGAAPYKPPHQRQEEKLSQEKVLNFE 660
ELMKSLLPVDRSCEDLVVDASLSFLDGFVAEGLSQGAAPYKPPHQRQEEKLSQEKVLNFE
Sbjct: 601 ELMKSLLPVDRSCEDLVVDASLSFLDGFVAEGLSQGAAPYKPPHQRQEEKLSQEKVLNFE 660
Query: 661 PYGLSFSSSGFTGRQSPAGISLGSDVSGNSAETGLKETNSLKLEGIKKLWGKEGYLPKKE 720
PYGLSFSSSGFTGRQSPAGISLGSDVSGNSAETGLKETNSLKLEGIKKLWGKEGYLPKKE
Sbjct: 661 PYGLSFSSSGFTGRQSPAGISLGSDVSGNSAETGLKETNSLKLEGIKKLWGKEGYLPKKE 720
Query: 721 SKTGDESGALPVPQESIMENVDQAITKKDQSQVLTQSKEEKEKQLLASSLFVGLGSESTI 780
SKTGDESGALPVPQESIMENVDQAITKKDQSQVLTQSKEEKEKQLLASSLFVGLGSESTI
Sbjct: 721 SKTGDESGALPVPQESIMENVDQAITKKDQSQVLTQSKEEKEKQLLASSLFVGLGSESTI 780
Query: 781 NLLGKADTVSHKFRRKSKVKEAKSGETTSTHNMTCSSFSSLSNVAYEDDYYSNTLHDTGD 840
NLLGKADTVSHKFRRKSKVKEAKSGETTSTHNMTCSSFSSLSNVAYEDDYYSNTLHDTGD
Sbjct: 781 NLLGKADTVSHKFRRKSKVKEAKSGETTSTHNMTCSSFSSLSNVAYEDDYYSNTLHDTGD 840
Query: 841 KELKKFSLTSELLDSESLTELPLVEKFSYCSLSTPSLFANNNMEIFHPPQSTAASVAKES 900
KELKKFSLTSELLDSESLTELPLVEKFSYCSLSTPSLFANNNMEIFHPPQSTAASVAKES
Sbjct: 841 KELKKFSLTSELLDSESLTELPLVEKFSYCSLSTPSLFANNNMEIFHPPQSTAASVAKES 900
Query: 901 SLASSFLEETTEYIHSNAMEVCNNETISVSSYKIWKDDCLLMVWSVTNKSGLELKSADLE 960
SLASSFLEETTEYIHSNAMEVCNNETISVSSYKIWKDDCLLMVWSVTNKSGLELKSADLE
Sbjct: 901 SLASSFLEETTEYIHSNAMEVCNNETISVSSYKIWKDDCLLMVWSVTNKSGLELKSADLE 960
Query: 961 IFPAENFKVTEQPGCCLPVMEAESTKSFQYSVQIEKPFTEGNLTGFISYHMMDTHSAQLE 1020
IFPAENFKVTEQPGCCLPVMEAESTKSFQYSVQIEKPFTEGNLTGFISYHMMDTHSAQLE
Sbjct: 961 IFPAENFKVTEQPGCCLPVMEAESTKSFQYSVQIEKPFTEGNLTGFISYHMMDTHSAQLE 1020
Query: 1021 FSVNLSLLDFIRPLKISSDDFGKLWLSFANDVKQNVKMSESQAALPSALKTLQQKLRLHI 1080
FSVNLSLLDFIRPLKISSDDFGKLWLSFANDVKQNVKMSESQAALPSALKTLQQKLRLHI
Sbjct: 1021 FSVNLSLLDFIRPLKISSDDFGKLWLSFANDVKQNVKMSESQAALPSALKTLQQKLRLHI 1080
Query: 1081 IEIIGNEGLLACQLLPSIPCLLHCRVHADVLALWFRSSCSTLPDYLLYQCQKVMEGS 1137
IEIIGNEGLLACQLLPSIPCLLHCRVHADVLALWFRSSCSTLPDYLLYQCQKVMEGS
Sbjct: 1081 IEIIGNEGLLACQLLPSIPCLLHCRVHADVLALWFRSSCSTLPDYLLYQCQKVMEGS 1137
>gi|71772942 adaptor-related protein complex 1, gamma 1 subunit
isoform b [Homo sapiens]
Length = 822
Score = 238 bits (606), Expect = 3e-62
Identities = 162/588 (27%), Positives = 295/588 (50%), Gaps = 28/588 (4%)
Query: 35 RLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDA 94
RL L+R I ++ EE ++IQ+E ++++++ T + + +L+Y MLGY A
Sbjct: 6 RLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRN--VAKLLYMHMLGYPA 63
Query: 95 SFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMAL 154
FG + +KL +KR+GYL L L E ++ LL+ N + DL + +AL
Sbjct: 64 HFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLAL 123
Query: 155 TVVSQIFPCEMIPAVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFRKAL 214
+ + EM + +E L+ S +R+KA L P ++ + L
Sbjct: 124 CTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLL 183
Query: 215 CDRDVGVMAASLHIYLRMIKENS---SGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAP 271
+++ GV+ S+ + M + + + ++ L V ILK ++ E + + P
Sbjct: 184 NEKNHGVLHTSVVLLTEMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGISDP 243
Query: 272 WLQIQLLRILGLLGKDDQRTSELMYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKS 331
+LQ+++LR+L +LG++D +SE M D+L + E + NV AIL+E V T+ I +S
Sbjct: 244 FLQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSES 303
Query: 332 ELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPIIKR 391
L A +G+F+L+ N++Y+ L +L +Q D +H+ TI++CL D IKR
Sbjct: 304 GLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKR 363
Query: 392 ETLELLYRITNAQNITVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTM 451
+EL + + N NI +++++L +L + E+ + I AEKYAP W I T+
Sbjct: 364 RAMELSFALVNGNNIRGMMKELLYFLDSCEPEFK-ADCASGIFLAAEKYAPSKRWHIDTI 422
Query: 452 NAVFSVGGDVMHPDIPNNFLRLLAEGFDDETEDQQLRLYAVQS-YLTLLDMENVFYPQRF 510
V + G + D N ++L+ T ++ Y VQ Y +L + Q
Sbjct: 423 MRVLTTAGSYVRDDAVPNLIQLI-------TNSVEMHAYTVQRLYKAIL---GDYSQQPL 472
Query: 511 LQVMSWVLGEYSYLL-----DKETP-----EEVIAKLYKLLMNDSVSSETKAWLIAAVTK 560
+QV +W +GEY LL ++E P +EV+ L +L+++ +S T+ + + A+ K
Sbjct: 473 VQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDILESVLISNMSTSVTRGYALTAIMK 532
Query: 561 LTSQ-AHSSNTVERLIHEFTISLDTCMRQHAFELKHLHENVELMKSLL 607
L+++ + N +++++ + S+D ++Q A E L + + M+S L
Sbjct: 533 LSTRFTCTVNRIKKVVSIYGSSIDVELQQRAVEYNALFKKYDHMRSAL 580
>gi|71773010 adaptor-related protein complex 1, gamma 1 subunit
isoform a [Homo sapiens]
Length = 825
Score = 234 bits (596), Expect = 5e-61
Identities = 162/591 (27%), Positives = 293/591 (49%), Gaps = 31/591 (5%)
Query: 35 RLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDA 94
RL L+R I ++ EE ++IQ+E ++++++ T + + +L+Y MLGY A
Sbjct: 6 RLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRN--VAKLLYMHMLGYPA 63
Query: 95 SFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMAL 154
FG + +KL +KR+GYL L L E ++ LL+ N + DL + +AL
Sbjct: 64 HFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLAL 123
Query: 155 TVVSQIFPCEMIPAVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFRKAL 214
+ + EM + +E L+ S +R+KA L P ++ + L
Sbjct: 124 CTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLL 183
Query: 215 CDRDVGVMAASLHIYLRMIKENSSGY------KDLTGSFVTILKQVVGGKLPVEFNYHSV 268
+++ GV+ S+ + M + + + L V ILK ++ E + +
Sbjct: 184 NEKNHGVLHTSVVLLTEMCERSPDMLAHFRKNEKLVPQLVRILKNLIMSGYSPEHDVSGI 243
Query: 269 PAPWLQIQLLRILGLLGKDDQRTSELMYDVLDESLRRAELNHNVTYAILFECVHTVYSIY 328
P+LQ+++LR+L +LG++D +SE M D+L + E + NV AIL+E V T+ I
Sbjct: 244 SDPFLQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIK 303
Query: 329 PKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPI 388
+S L A +G+F+L+ N++Y+ L +L +Q D +H+ TI++CL D
Sbjct: 304 SESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVS 363
Query: 389 IKRETLELLYRITNAQNITVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFI 448
IKR +EL + + N NI +++++L +L + E+ + I AEKYAP W I
Sbjct: 364 IKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFK-ADCASGIFLAAEKYAPSKRWHI 422
Query: 449 QTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDDETEDQQLRLYAVQS-YLTLLDMENVFYP 507
T+ V + G + D N ++L+ T ++ Y VQ Y +L +
Sbjct: 423 DTIMRVLTTAGSYVRDDAVPNLIQLI-------TNSVEMHAYTVQRLYKAIL---GDYSQ 472
Query: 508 QRFLQVMSWVLGEYSYLL-----DKETP-----EEVIAKLYKLLMNDSVSSETKAWLIAA 557
Q +QV +W +GEY LL ++E P +EV+ L +L+++ +S T+ + + A
Sbjct: 473 QPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDILESVLISNMSTSVTRGYALTA 532
Query: 558 VTKLTSQ-AHSSNTVERLIHEFTISLDTCMRQHAFELKHLHENVELMKSLL 607
+ KL+++ + N +++++ + S+D ++Q A E L + + M+S L
Sbjct: 533 IMKLSTRFTCTVNRIKKVVSIYGSSIDVELQQRAVEYNALFKKYDHMRSAL 583
>gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [Homo
sapiens]
Length = 785
Score = 216 bits (549), Expect = 1e-55
Identities = 152/589 (25%), Positives = 281/589 (47%), Gaps = 26/589 (4%)
Query: 33 SSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGY 92
S +L L+ I ++ +E ++IQ+E + ++A+ + + + +L+Y MLGY
Sbjct: 5 SLKLQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQ--LAKLLYVHMLGY 62
Query: 93 DASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCM 152
A FG + +KL +KRVGYL L L E H+ LL+ N++ DL +
Sbjct: 63 PAHFGQMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGL 122
Query: 153 ALTVVSQIFPCEMIPAVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFRK 212
AL +S + EM + P +E L VR+KA+L P +
Sbjct: 123 ALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQ 182
Query: 213 ALCDRDVGVMAASLHIYLRMIKENSSG---YKDLTGSFVTILKQVVGGKLPVEFNYHSVP 269
L +R G++ ++ + + + + + ++ + V IL+ +V E + V
Sbjct: 183 LLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVS 242
Query: 270 APWLQIQLLRILGLLGKDDQRTSELMYDVLDESLRRAELNHNVTYAILFECVHTVYSIYP 329
P+LQ+Q+LR+L +LG++ + +SE M D+L + + + N A+LFE V T+ I
Sbjct: 243 DPFLQVQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRS 302
Query: 330 KSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPII 389
+ L A +G+F+L+ N++Y+ L +L ++Q D + +H+ T++ECL D +
Sbjct: 303 AAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASL 362
Query: 390 KRETLELLYRITNAQNITVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQ 449
R LEL + N+ N+ ++Q++ +L + + + I AE++AP W I
Sbjct: 363 SRRALELSLALVNSSNVRAMMQELQAFLESCPPD-LRADCASGILLAAERFAPTKRWHID 421
Query: 450 TMNAVFSVGGDVMHPDIPNNFLRLLAEGFDDETEDQQLRLYAVQSYLTLLDMENVFYPQR 509
T+ V + G + D N +L+ Q+L Y+V+ L + Q
Sbjct: 422 TILHVLTTAGTHVRDDAVANLTQLIGGA-------QELHAYSVRRLYNALAED--ISQQP 472
Query: 510 FLQVMSWVLGEYSYLL-----DKETP-----EEVIAKLYKLLMNDSVSSETKAWLIAAVT 559
+QV +W +GEY LL ++ P EEV+A L K+L + T+ + + A+
Sbjct: 473 LVQVAAWCIGEYGDLLLAGNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTALM 532
Query: 560 KLTSQ-AHSSNTVERLIHEFTISLDTCMRQHAFELKHLHENVELMKSLL 607
KL+++ +N + +++ + LD ++Q A E L + M++ +
Sbjct: 533 KLSTRLCGDNNRIRQVVSIYGSCLDVELQQRAVEYDTLFRKYDHMRAAI 581
>gi|19913414 adaptor-related protein complex 2, alpha 1 subunit
isoform 1 [Homo sapiens]
Length = 977
Score = 169 bits (427), Expect = 2e-41
Identities = 135/523 (25%), Positives = 247/523 (47%), Gaps = 35/523 (6%)
Query: 25 PAAAKASFSSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMV-R 83
PA +K L + I SK E K I +EL+++++ K+ V +
Sbjct: 2 PAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCK 61
Query: 84 LIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQ 143
L++ +LG+D FG++ A+ L EK++GYL +S+ ++ + EL+ L+ N + DL
Sbjct: 62 LLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLA 121
Query: 144 STNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKL--QHSKEIVRRKAVLALYKFHLIAPN 201
S N +C+AL ++ + EM A I L S + V++ A L L + + +P+
Sbjct: 122 SRNPTFMCLALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPD 181
Query: 202 QVQHIHIKFR--KALCDRDVGVMAASLHIYLRMIKENSSGYKDLTGSFVTILKQVVGGKL 259
V R L D+ +GV+ A++ + + K+N +K V+ L ++V
Sbjct: 182 LVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSAS 241
Query: 260 P--VEFNYHSVPAPWLQIQLLRILGLL-GKDDQRTSELMYDVLDESLRRAE--------L 308
++ Y+ VPAPWL ++LLR+L +D + + L+ L +A+
Sbjct: 242 TDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQ 301
Query: 309 NHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQD- 367
+ N AILFE + + + LL +A +G+F+ + NL+YL L+++ + +
Sbjct: 302 HSNAKNAILFETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEF 361
Query: 368 -PTLALQHQMTIIECL-DHPDPIIKRETLELLYRITNAQNITVIVQKMLEYLHQSKEEYV 425
H T+I L D +++ +LLY + + N IV +ML YL ++ + +
Sbjct: 362 SHEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYL-ETADYAI 420
Query: 426 IVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDDETEDQ 485
+V K+A LAEKYA D +W++ T+ + + GD + ++ L+++ D
Sbjct: 421 REEIVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDD------ 474
Query: 486 QLRLYAVQSYLTLLDMENVFYP---QRFLQVMSWVLGEYSYLL 525
VQ Y E + P + ++V ++LGE+ L+
Sbjct: 475 ------VQGYAAKTVFEALQAPACHENMVKVGGYILGEFGNLI 511
>gi|19913416 adaptor-related protein complex 2, alpha 1 subunit
isoform 2 [Homo sapiens]
Length = 955
Score = 169 bits (427), Expect = 2e-41
Identities = 135/523 (25%), Positives = 247/523 (47%), Gaps = 35/523 (6%)
Query: 25 PAAAKASFSSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMV-R 83
PA +K L + I SK E K I +EL+++++ K+ V +
Sbjct: 2 PAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCK 61
Query: 84 LIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQ 143
L++ +LG+D FG++ A+ L EK++GYL +S+ ++ + EL+ L+ N + DL
Sbjct: 62 LLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLA 121
Query: 144 STNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKL--QHSKEIVRRKAVLALYKFHLIAPN 201
S N +C+AL ++ + EM A I L S + V++ A L L + + +P+
Sbjct: 122 SRNPTFMCLALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPD 181
Query: 202 QVQHIHIKFR--KALCDRDVGVMAASLHIYLRMIKENSSGYKDLTGSFVTILKQVVGGKL 259
V R L D+ +GV+ A++ + + K+N +K V+ L ++V
Sbjct: 182 LVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSAS 241
Query: 260 P--VEFNYHSVPAPWLQIQLLRILGLL-GKDDQRTSELMYDVLDESLRRAE--------L 308
++ Y+ VPAPWL ++LLR+L +D + + L+ L +A+
Sbjct: 242 TDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQ 301
Query: 309 NHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQD- 367
+ N AILFE + + + LL +A +G+F+ + NL+YL L+++ + +
Sbjct: 302 HSNAKNAILFETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEF 361
Query: 368 -PTLALQHQMTIIECL-DHPDPIIKRETLELLYRITNAQNITVIVQKMLEYLHQSKEEYV 425
H T+I L D +++ +LLY + + N IV +ML YL ++ + +
Sbjct: 362 SHEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYL-ETADYAI 420
Query: 426 IVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDDETEDQ 485
+V K+A LAEKYA D +W++ T+ + + GD + ++ L+++ D
Sbjct: 421 REEIVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDD------ 474
Query: 486 QLRLYAVQSYLTLLDMENVFYP---QRFLQVMSWVLGEYSYLL 525
VQ Y E + P + ++V ++LGE+ L+
Sbjct: 475 ------VQGYAAKTVFEALQAPACHENMVKVGGYILGEFGNLI 511
>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
isoform 2 [Homo sapiens]
Length = 1153
Score = 164 bits (415), Expect = 4e-40
Identities = 123/510 (24%), Positives = 230/510 (45%), Gaps = 49/510 (9%)
Query: 32 FSSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLG 91
F L LVRGI K +E K I Q + +K + +K C +L Y +MLG
Sbjct: 14 FDKNLQDLVRGIR--NHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC--KLTYLQMLG 69
Query: 92 YDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVC 151
YD S+ + I++ KR+GYLA S HE ++++L N + KDL S + +
Sbjct: 70 YDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTG 129
Query: 152 MALTVVSQIFPCEMIPAVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFR 211
+ALT +S ++ + I + H+K +R+KAVL +YK L P ++ + +
Sbjct: 130 VALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLK 189
Query: 212 KALCDRDVGVMAASLHIYLRMIKENSSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAP 271
+ L D D GV +A++++ + + N Y L F ++
Sbjct: 190 EKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNN-------------- 235
Query: 272 WLQIQLLRILGLLGKDDQRTSELMYDVLDESLRRAELNHNVTYAILFECVHTVYSIY--- 328
W+ I+++++ G L + R + + + L + ++L+ECV+TV ++
Sbjct: 236 WVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTS-----AMSLLYECVNTVIAVLISL 290
Query: 329 -----PKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLD 383
S ++ + + + NLKYLGL A++ +++ P H+ I++CLD
Sbjct: 291 SSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLD 350
Query: 384 HPDPIIKRETLELLYRITNAQNITVIVQKMLEYLHQSKEEYVIVNLVGKIAELAE----K 439
D I+ L+LLY + + +N+ IV+K++ ++ +++ L+ KI ++ +
Sbjct: 351 DKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQ 410
Query: 440 YAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDDETEDQQLRLYAVQSYLTLL 499
Y + W+I + + + G H + + A+ D + +R +AV LL
Sbjct: 411 YITNFEWYISILVELTRLEG-TRHGHL------IAAQMLDVAIRVKAIRKFAVSQMSALL 463
Query: 500 DMENVFYPQ-------RFLQVMSWVLGEYS 522
D ++ L +W+ GE+S
Sbjct: 464 DSAHLLASSTQRNGICEVLYAAAWICGEFS 493
>gi|27477041 adaptor-related protein complex 2, alpha 2 subunit
[Homo sapiens]
Length = 939
Score = 164 bits (414), Expect = 6e-40
Identities = 136/566 (24%), Positives = 262/566 (46%), Gaps = 45/566 (7%)
Query: 25 PAAAKASFSSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMV-R 83
PA +K L + I SK E K I +EL+++++ K+ V +
Sbjct: 2 PAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCK 61
Query: 84 LIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQ 143
L++ +LG+D FG++ A+ L EK++GYL +S+ ++ + EL+ L+ N + DL
Sbjct: 62 LLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLA 121
Query: 144 STNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKL--QHSKEIVRRKAVLALYKFHLIAPN 201
S N + +AL ++ + EM A I L + + V++ A L L + + +P+
Sbjct: 122 SRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSPD 181
Query: 202 QV-------QHIHIKFRKALCDRDVGVMAASLHIYLRMIKENSSGYKDLTGSFVTILKQV 254
V + +H+ L D+ +GV+ A+ + + ++N +K V+ L ++
Sbjct: 182 LVPMGDWTSRVVHL-----LNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRI 236
Query: 255 VGGKLP--VEFNYHSVPAPWLQIQLLRILGLLGKDDQRTSELMYDVLDESLRRAE----- 307
V ++ Y+ VPAPWL ++LLR+L D + + L+ L +A+
Sbjct: 237 VTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPDPAVRGRLTECLETILNKAQEPPKS 296
Query: 308 ---LNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVI 364
+ N A+LFE + + + LL +A +G+F+ + NL+YL L+++ +
Sbjct: 297 KKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLA 356
Query: 365 QQD--PTLALQHQMTIIECL-DHPDPIIKRETLELLYRITNAQNITVIVQKMLEYLHQSK 421
+ H T+I L D +++ ++LLY + + N IV +ML YL ++
Sbjct: 357 SSEFSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYL-ETA 415
Query: 422 EEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDDE 481
+ + +V K+A LAEKYA D W++ T+ + + GD + ++ ++++ D
Sbjct: 416 DYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDD-- 473
Query: 482 TEDQQLRLYAVQSYLTLLDMENVFYP---QRFLQVMSWVLGEYSYLLDKETPEEVIAKLY 538
VQ Y E + P + ++V ++LGE+ L+ + + + +
Sbjct: 474 ----------VQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFH 523
Query: 539 KLLMNDSVSS-ETKAWLIAAVTKLTS 563
L + S T+A L++ K +
Sbjct: 524 LLHSKFHLCSVPTRALLLSTYIKFVN 549
>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
isoform 1 [Homo sapiens]
Length = 1112
Score = 77.8 bits (190), Expect = 5e-14
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 4/159 (2%)
Query: 32 FSSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLG 91
F L LVRGI K +E K I Q + +K + +K C +L Y +MLG
Sbjct: 14 FDKNLQDLVRGIR--NHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC--KLTYLQMLG 69
Query: 92 YDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVC 151
YD S+ + I++ KR+GYLA S HE ++++L N + KDL S + +
Sbjct: 70 YDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTG 129
Query: 152 MALTVVSQIFPCEMIPAVLPLIEDKLQHSKEIVRRKAVL 190
+ALT +S ++ + I + H+K +R+KA L
Sbjct: 130 VALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAKL 168
Score = 69.3 bits (168), Expect = 2e-11
Identities = 52/227 (22%), Positives = 105/227 (46%), Gaps = 26/227 (11%)
Query: 315 AILFECVHTVYSIYPK--------SELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQ 366
++L+ECV+TV ++ S ++ + + + NLKYLGL A++ +++
Sbjct: 183 SLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKT 242
Query: 367 DPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQNITVIVQKMLEYLHQSKEEYVI 426
P H+ I++CLD D I+ L+LLY + + +N+ IV+K++ ++ +++
Sbjct: 243 HPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYR 302
Query: 427 VNLVGKIAELAE----KYAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDDET 482
L+ KI ++ +Y + W+I + + + G H + + A+ D
Sbjct: 303 DELLTKIIDICSQSNYQYITNFEWYISILVELTRLEG-TRHGHL------IAAQMLDVAI 355
Query: 483 EDQQLRLYAVQSYLTLLDMENVFYPQ-------RFLQVMSWVLGEYS 522
+ +R +AV LLD ++ L +W+ GE+S
Sbjct: 356 RVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFS 402
>gi|22027651 adaptor-related protein complex 1 beta 1 subunit
isoform a [Homo sapiens]
Length = 949
Score = 67.0 bits (162), Expect = 1e-10
Identities = 108/472 (22%), Positives = 195/472 (41%), Gaps = 55/472 (11%)
Query: 59 ELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYL 118
E+ LKA +++ K KE + ++I +G D S + + Q NL K++ YL
Sbjct: 14 EIFELKAELNSDKKEKK--KEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYL 71
Query: 119 AVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQ 178
+ + ++ ++ VNT VKD + N + +A+ + I ++ + + L+
Sbjct: 72 YLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131
Query: 179 HSKEIVRRKAVLALYKFHLIAPNQVQ-HIHIKFRKALCDRDVGVMAASLHIYLRMIKEN- 236
VR+ A + + K H I V+ + K L ++ A+ L I E+
Sbjct: 132 DEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESH 191
Query: 237 -SSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRIL-GLLGKDDQRTSEL 294
SS DL + KL N + W QI +L L + KDD+ +
Sbjct: 192 PSSNLLDLNPQSI--------NKLLTALNECT---EWGQIFILDCLANYMPKDDREAQSI 240
Query: 295 MYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKF---------- 344
V L+H A++ V + E+L K G
Sbjct: 241 CERV------TPRLSH-ANSAVVLSAVKVLMKF---MEMLSKDLDYYGTLLKKLAPPLVT 290
Query: 345 VLSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPI-IKRETLELLYRITNA 403
+LS + L+Y+ L+ + ++Q+ P + L+H+M + + + DPI +K E L+++ R+ +
Sbjct: 291 LLSAEPELQYVALRNINLIVQKRPEI-LKHEMKVF-FVKYNDPIYVKLEKLDIMIRLASQ 348
Query: 404 QNITVIVQKMLEYLHQSKEEYV--IVNLVG----KIAELAEKYAPDNAWFIQTMNAVFSV 457
NI ++ ++ EY + ++V V +G K+ + AE+ IQT
Sbjct: 349 ANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQ 408
Query: 458 GGDVMHPDI----PNNF---LRLLAEGFD--DETEDQQLRLYAVQSYLTLLD 500
V+ DI PN + + L E D DE E + ++ V Y +D
Sbjct: 409 EAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERID 460
>gi|22027653 adaptor-related protein complex 1 beta 1 subunit
isoform b [Homo sapiens]
Length = 942
Score = 67.0 bits (162), Expect = 1e-10
Identities = 108/472 (22%), Positives = 195/472 (41%), Gaps = 55/472 (11%)
Query: 59 ELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYL 118
E+ LKA +++ K KE + ++I +G D S + + Q NL K++ YL
Sbjct: 14 EIFELKAELNSDKKEKK--KEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYL 71
Query: 119 AVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQ 178
+ + ++ ++ VNT VKD + N + +A+ + I ++ + + L+
Sbjct: 72 YLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131
Query: 179 HSKEIVRRKAVLALYKFHLIAPNQVQ-HIHIKFRKALCDRDVGVMAASLHIYLRMIKEN- 236
VR+ A + + K H I V+ + K L ++ A+ L I E+
Sbjct: 132 DEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESH 191
Query: 237 -SSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRIL-GLLGKDDQRTSEL 294
SS DL + KL N + W QI +L L + KDD+ +
Sbjct: 192 PSSNLLDLNPQSI--------NKLLTALNECT---EWGQIFILDCLANYMPKDDREAQSI 240
Query: 295 MYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKF---------- 344
V L+H A++ V + E+L K G
Sbjct: 241 CERV------TPRLSH-ANSAVVLSAVKVLMKF---MEMLSKDLDYYGTLLKKLAPPLVT 290
Query: 345 VLSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPI-IKRETLELLYRITNA 403
+LS + L+Y+ L+ + ++Q+ P + L+H+M + + + DPI +K E L+++ R+ +
Sbjct: 291 LLSAEPELQYVALRNINLIVQKRPEI-LKHEMKVF-FVKYNDPIYVKLEKLDIMIRLASQ 348
Query: 404 QNITVIVQKMLEYLHQSKEEYV--IVNLVG----KIAELAEKYAPDNAWFIQTMNAVFSV 457
NI ++ ++ EY + ++V V +G K+ + AE+ IQT
Sbjct: 349 ANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQ 408
Query: 458 GGDVMHPDI----PNNF---LRLLAEGFD--DETEDQQLRLYAVQSYLTLLD 500
V+ DI PN + + L E D DE E + ++ V Y +D
Sbjct: 409 EAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERID 460
>gi|221316632 coatomer protein complex, subunit beta 1 [Homo
sapiens]
Length = 953
Score = 60.5 bits (145), Expect = 9e-09
Identities = 102/445 (22%), Positives = 186/445 (41%), Gaps = 83/445 (18%)
Query: 124 LHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQHSKEI 183
LHE ++L+ + KDLQ N L + ++ E++ ++P I L+H
Sbjct: 95 LHE----MILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSY 150
Query: 184 VRRKAVLALYKF-----HLI--APNQVQHIHIKFRKALCDRDVGVMAASLHIYLRMIKEN 236
VRR AVLA+Y HLI AP + + + A C R+ +M +H +
Sbjct: 151 VRRNAVLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMML--IHADQDRALDY 208
Query: 237 SSGYKDLTGSFVTILKQVVGGKLPVEFNY---HSVPAPWLQIQLLRILGLLGKDDQRTSE 293
S D +F IL+ V+ VE Y H+ P+ + R
Sbjct: 209 LSTCIDQVQTFGDILQLVI-----VELIYKVCHANPS----------------ERARFIR 247
Query: 294 LMYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKC-IGKFVLSPKINL 352
+Y++L S + A+ +E T+ ++ ++ AA+C I + N+
Sbjct: 248 CIYNLLQSS----------SPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNV 297
Query: 353 KYLGLKALTYVIQQDPTLALQHQ---MTIIECLDHPDPIIKRETLELLYRITNAQNITVI 409
K + L L +++ P Q M I+ L PD ++++TL+L + +++N+ +
Sbjct: 298 KLIVLDRL-IELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEEL 356
Query: 410 VQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNN 469
V + K+E + N V + E +KY ++T+++ V PD+ N
Sbjct: 357 VIVL-------KKEVIKTNNVSE-HEDTDKY---RQLLVRTLHSC-----SVRFPDMAAN 400
Query: 470 FLRLLAEGFDDETEDQQLRLY-----AVQSY-----LTLLDMENVFYPQRFLQVMS---W 516
+ +L E D E + A+Q + L + M VF+ + +++ W
Sbjct: 401 VIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALW 460
Query: 517 VLGEYSYLLDKETPEEVIAKLYKLL 541
+LGE Y KE + V+ ++ + L
Sbjct: 461 ILGE--YCSTKEDIQSVMTEIRRSL 483
Score = 40.8 bits (94), Expect = 0.007
Identities = 83/417 (19%), Positives = 153/417 (36%), Gaps = 41/417 (9%)
Query: 714 GYLPKKESKTGDESGALPVPQESIMENVDQAITKKDQ---SQVLTQSKEEKEKQ------ 764
G +P ES+ E+G L +E + V + +T+ L+ S+ K+++
Sbjct: 484 GEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRPPLR 543
Query: 765 --LLASSLFVGLGSESTIN--LLGKADTVSHKFRRKSKVKEAKSGETTSTHNMTCSSFSS 820
LL FV +T+ L V K ++ S V EA T H SS
Sbjct: 544 GFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILH----LGKSS 599
Query: 821 LSNVAYEDDYY-------------SNTLHDTGDKELKKF--SLTSELLDSESLTELPLVE 865
L DD S ++D +KE ++ + S L+ E L++ E
Sbjct: 600 LPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESE 659
Query: 866 KFSYC-----SLSTPSLFANNNMEIFHPPQSTAASVAKESSLASSFLEETTEYIHSNAME 920
K + +S L A N M + A ++ + ++
Sbjct: 660 KRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQL 719
Query: 921 VCNNETISVSSYKIWKDDCLLMVWSVTNKSGLELKSADLEIFPAENFKVTEQPG-CCLPV 979
++ + +Y +++ V N++ L++ LE+ + K+ E+P L
Sbjct: 720 TGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAP 779
Query: 980 MEAESTKSFQYSVQIEKPFTEGNLTGFISYHMMDTHSAQLEFSVNLSLLDFIRPLKISSD 1039
+ + K+ E GN+ +S D + L +++ ++D+I+P +
Sbjct: 780 HDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLS-DIHIDIMDYIQPATCTDA 838
Query: 1040 DFGKLWLSF--ANDVKQNVKMSESQAALPSALKTLQQKLRLHIIEIIGNEGLLACQL 1094
+F ++W F N V N M + L LK+ K + G G +A L
Sbjct: 839 EFRQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANL 895
>gi|221316630 coatomer protein complex, subunit beta 1 [Homo
sapiens]
Length = 953
Score = 60.5 bits (145), Expect = 9e-09
Identities = 102/445 (22%), Positives = 186/445 (41%), Gaps = 83/445 (18%)
Query: 124 LHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQHSKEI 183
LHE ++L+ + KDLQ N L + ++ E++ ++P I L+H
Sbjct: 95 LHE----MILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSY 150
Query: 184 VRRKAVLALYKF-----HLI--APNQVQHIHIKFRKALCDRDVGVMAASLHIYLRMIKEN 236
VRR AVLA+Y HLI AP + + + A C R+ +M +H +
Sbjct: 151 VRRNAVLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMML--IHADQDRALDY 208
Query: 237 SSGYKDLTGSFVTILKQVVGGKLPVEFNY---HSVPAPWLQIQLLRILGLLGKDDQRTSE 293
S D +F IL+ V+ VE Y H+ P+ + R
Sbjct: 209 LSTCIDQVQTFGDILQLVI-----VELIYKVCHANPS----------------ERARFIR 247
Query: 294 LMYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKC-IGKFVLSPKINL 352
+Y++L S + A+ +E T+ ++ ++ AA+C I + N+
Sbjct: 248 CIYNLLQSS----------SPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNV 297
Query: 353 KYLGLKALTYVIQQDPTLALQHQ---MTIIECLDHPDPIIKRETLELLYRITNAQNITVI 409
K + L L +++ P Q M I+ L PD ++++TL+L + +++N+ +
Sbjct: 298 KLIVLDRL-IELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEEL 356
Query: 410 VQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNN 469
V + K+E + N V + E +KY ++T+++ V PD+ N
Sbjct: 357 VIVL-------KKEVIKTNNVSE-HEDTDKY---RQLLVRTLHSC-----SVRFPDMAAN 400
Query: 470 FLRLLAEGFDDETEDQQLRLY-----AVQSY-----LTLLDMENVFYPQRFLQVMS---W 516
+ +L E D E + A+Q + L + M VF+ + +++ W
Sbjct: 401 VIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALW 460
Query: 517 VLGEYSYLLDKETPEEVIAKLYKLL 541
+LGE Y KE + V+ ++ + L
Sbjct: 461 ILGE--YCSTKEDIQSVMTEIRRSL 483
Score = 40.8 bits (94), Expect = 0.007
Identities = 83/417 (19%), Positives = 153/417 (36%), Gaps = 41/417 (9%)
Query: 714 GYLPKKESKTGDESGALPVPQESIMENVDQAITKKDQ---SQVLTQSKEEKEKQ------ 764
G +P ES+ E+G L +E + V + +T+ L+ S+ K+++
Sbjct: 484 GEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRPPLR 543
Query: 765 --LLASSLFVGLGSESTIN--LLGKADTVSHKFRRKSKVKEAKSGETTSTHNMTCSSFSS 820
LL FV +T+ L V K ++ S V EA T H SS
Sbjct: 544 GFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILH----LGKSS 599
Query: 821 LSNVAYEDDYY-------------SNTLHDTGDKELKKF--SLTSELLDSESLTELPLVE 865
L DD S ++D +KE ++ + S L+ E L++ E
Sbjct: 600 LPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESE 659
Query: 866 KFSYC-----SLSTPSLFANNNMEIFHPPQSTAASVAKESSLASSFLEETTEYIHSNAME 920
K + +S L A N M + A ++ + ++
Sbjct: 660 KRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQL 719
Query: 921 VCNNETISVSSYKIWKDDCLLMVWSVTNKSGLELKSADLEIFPAENFKVTEQPG-CCLPV 979
++ + +Y +++ V N++ L++ LE+ + K+ E+P L
Sbjct: 720 TGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAP 779
Query: 980 MEAESTKSFQYSVQIEKPFTEGNLTGFISYHMMDTHSAQLEFSVNLSLLDFIRPLKISSD 1039
+ + K+ E GN+ +S D + L +++ ++D+I+P +
Sbjct: 780 HDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLS-DIHIDIMDYIQPATCTDA 838
Query: 1040 DFGKLWLSF--ANDVKQNVKMSESQAALPSALKTLQQKLRLHIIEIIGNEGLLACQL 1094
+F ++W F N V N M + L LK+ K + G G +A L
Sbjct: 839 EFRQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANL 895
>gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens]
Length = 953
Score = 60.5 bits (145), Expect = 9e-09
Identities = 102/445 (22%), Positives = 186/445 (41%), Gaps = 83/445 (18%)
Query: 124 LHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQHSKEI 183
LHE ++L+ + KDLQ N L + ++ E++ ++P I L+H
Sbjct: 95 LHE----MILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSY 150
Query: 184 VRRKAVLALYKF-----HLI--APNQVQHIHIKFRKALCDRDVGVMAASLHIYLRMIKEN 236
VRR AVLA+Y HLI AP + + + A C R+ +M +H +
Sbjct: 151 VRRNAVLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMML--IHADQDRALDY 208
Query: 237 SSGYKDLTGSFVTILKQVVGGKLPVEFNY---HSVPAPWLQIQLLRILGLLGKDDQRTSE 293
S D +F IL+ V+ VE Y H+ P+ + R
Sbjct: 209 LSTCIDQVQTFGDILQLVI-----VELIYKVCHANPS----------------ERARFIR 247
Query: 294 LMYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKC-IGKFVLSPKINL 352
+Y++L S + A+ +E T+ ++ ++ AA+C I + N+
Sbjct: 248 CIYNLLQSS----------SPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNV 297
Query: 353 KYLGLKALTYVIQQDPTLALQHQ---MTIIECLDHPDPIIKRETLELLYRITNAQNITVI 409
K + L L +++ P Q M I+ L PD ++++TL+L + +++N+ +
Sbjct: 298 KLIVLDRL-IELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEEL 356
Query: 410 VQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNN 469
V + K+E + N V + E +KY ++T+++ V PD+ N
Sbjct: 357 VIVL-------KKEVIKTNNVSE-HEDTDKY---RQLLVRTLHSC-----SVRFPDMAAN 400
Query: 470 FLRLLAEGFDDETEDQQLRLY-----AVQSY-----LTLLDMENVFYPQRFLQVMS---W 516
+ +L E D E + A+Q + L + M VF+ + +++ W
Sbjct: 401 VIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALW 460
Query: 517 VLGEYSYLLDKETPEEVIAKLYKLL 541
+LGE Y KE + V+ ++ + L
Sbjct: 461 ILGE--YCSTKEDIQSVMTEIRRSL 483
Score = 40.8 bits (94), Expect = 0.007
Identities = 83/417 (19%), Positives = 153/417 (36%), Gaps = 41/417 (9%)
Query: 714 GYLPKKESKTGDESGALPVPQESIMENVDQAITKKDQ---SQVLTQSKEEKEKQ------ 764
G +P ES+ E+G L +E + V + +T+ L+ S+ K+++
Sbjct: 484 GEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRPPLR 543
Query: 765 --LLASSLFVGLGSESTIN--LLGKADTVSHKFRRKSKVKEAKSGETTSTHNMTCSSFSS 820
LL FV +T+ L V K ++ S V EA T H SS
Sbjct: 544 GFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILH----LGKSS 599
Query: 821 LSNVAYEDDYY-------------SNTLHDTGDKELKKF--SLTSELLDSESLTELPLVE 865
L DD S ++D +KE ++ + S L+ E L++ E
Sbjct: 600 LPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESE 659
Query: 866 KFSYC-----SLSTPSLFANNNMEIFHPPQSTAASVAKESSLASSFLEETTEYIHSNAME 920
K + +S L A N M + A ++ + ++
Sbjct: 660 KRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQL 719
Query: 921 VCNNETISVSSYKIWKDDCLLMVWSVTNKSGLELKSADLEIFPAENFKVTEQPG-CCLPV 979
++ + +Y +++ V N++ L++ LE+ + K+ E+P L
Sbjct: 720 TGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAP 779
Query: 980 MEAESTKSFQYSVQIEKPFTEGNLTGFISYHMMDTHSAQLEFSVNLSLLDFIRPLKISSD 1039
+ + K+ E GN+ +S D + L +++ ++D+I+P +
Sbjct: 780 HDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLS-DIHIDIMDYIQPATCTDA 838
Query: 1040 DFGKLWLSF--ANDVKQNVKMSESQAALPSALKTLQQKLRLHIIEIIGNEGLLACQL 1094
+F ++W F N V N M + L LK+ K + G G +A L
Sbjct: 839 EFRQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANL 895
>gi|71773106 adaptor-related protein complex 2, beta 1 subunit
isoform a [Homo sapiens]
Length = 951
Score = 60.5 bits (145), Expect = 9e-09
Identities = 99/467 (21%), Positives = 194/467 (41%), Gaps = 45/467 (9%)
Query: 59 ELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYL 118
E+ LKA ++ + KE + ++I +G D S + + Q NL K++ YL
Sbjct: 14 EIFELKAELN--NEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYL 71
Query: 119 AVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQ 178
+ + ++ ++ VN+ VKD + N + +A+ + I ++ + + L+
Sbjct: 72 YLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131
Query: 179 HSKEIVRRKAVLALYKFHLIAPNQV--QHIHIKFRKALCDRDVGVMAASLHIYLRMIKEN 236
VR+ A + + K H I V Q R + D + V+A ++ L I E+
Sbjct: 132 DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAV-AALSEISES 190
Query: 237 --SSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLLGKDDQRTSEL 294
+S DL + KL N + W QI +L L D R ++
Sbjct: 191 HPNSNLLDLNPQNI--------NKLLTALNECT---EWGQIFILDCLSNYNPKDDREAQS 239
Query: 295 MYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSE-----LLEKAAKCIGKFVLSPK 349
+ + + L A ++ + + + PK LL+K A + +LS +
Sbjct: 240 ICERVTPRLSHA---NSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPL-VTLLSGE 295
Query: 350 INLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPI-IKRETLELLYRITNAQNITV 408
++Y+ L+ + ++Q+ P + Q + + DPI +K E L+++ R+ + NI
Sbjct: 296 PEVQYVALRNINLIVQKRPEILKQEIKVFF--VKYNDPIYVKLEKLDIMIRLASQANIAQ 353
Query: 409 IVQKMLEYLHQSKEEYV--IVNLVG----KIAELAEKYAPDNAWFIQT-----MNAVFSV 457
++ ++ EY + ++V V +G K+ + AE+ IQT + V
Sbjct: 354 VLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVV 413
Query: 458 GGDVM--HPDIPNNFLRLLAEGFD--DETEDQQLRLYAVQSYLTLLD 500
D+ +P+ + + L E D DE + + ++ V Y +D
Sbjct: 414 IRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERID 460
>gi|4557469 adaptor-related protein complex 2, beta 1 subunit
isoform b [Homo sapiens]
Length = 937
Score = 60.5 bits (145), Expect = 9e-09
Identities = 99/467 (21%), Positives = 194/467 (41%), Gaps = 45/467 (9%)
Query: 59 ELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYL 118
E+ LKA ++ + KE + ++I +G D S + + Q NL K++ YL
Sbjct: 14 EIFELKAELN--NEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYL 71
Query: 119 AVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQ 178
+ + ++ ++ VN+ VKD + N + +A+ + I ++ + + L+
Sbjct: 72 YLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131
Query: 179 HSKEIVRRKAVLALYKFHLIAPNQV--QHIHIKFRKALCDRDVGVMAASLHIYLRMIKEN 236
VR+ A + + K H I V Q R + D + V+A ++ L I E+
Sbjct: 132 DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAV-AALSEISES 190
Query: 237 --SSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLLGKDDQRTSEL 294
+S DL + KL N + W QI +L L D R ++
Sbjct: 191 HPNSNLLDLNPQNI--------NKLLTALNECT---EWGQIFILDCLSNYNPKDDREAQS 239
Query: 295 MYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSE-----LLEKAAKCIGKFVLSPK 349
+ + + L A ++ + + + PK LL+K A + +LS +
Sbjct: 240 ICERVTPRLSHA---NSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPL-VTLLSGE 295
Query: 350 INLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPI-IKRETLELLYRITNAQNITV 408
++Y+ L+ + ++Q+ P + Q + + DPI +K E L+++ R+ + NI
Sbjct: 296 PEVQYVALRNINLIVQKRPEILKQEIKVFF--VKYNDPIYVKLEKLDIMIRLASQANIAQ 353
Query: 409 IVQKMLEYLHQSKEEYV--IVNLVG----KIAELAEKYAPDNAWFIQT-----MNAVFSV 457
++ ++ EY + ++V V +G K+ + AE+ IQT + V
Sbjct: 354 VLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVV 413
Query: 458 GGDVM--HPDIPNNFLRLLAEGFD--DETEDQQLRLYAVQSYLTLLD 500
D+ +P+ + + L E D DE + + ++ V Y +D
Sbjct: 414 IRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERID 460
>gi|32484979 adaptor-related protein complex 3, beta 1 subunit [Homo
sapiens]
Length = 1094
Score = 50.4 bits (119), Expect = 9e-06
Identities = 89/442 (20%), Positives = 175/442 (39%), Gaps = 47/442 (10%)
Query: 20 QPGGGPAAAKASFSSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKE 79
Q GGG A ++ S +S ++ + ++Q L S K + +
Sbjct: 11 QSGGGEATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKL---------D 61
Query: 80 CMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVV 139
M R++ G +AS + +K N+ K++ Y+ + + E +L LL ++T
Sbjct: 62 AMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQ 121
Query: 140 KDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQHSKEIVRRKAVLALYKFHLIA 199
+ L+ N + AL V+S I ++P ++ I++ VR+ A A+ K + +
Sbjct: 122 RALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLD 181
Query: 200 PNQVQHIHIKFRKALCDRDVGVMAASLHIYLRMIKEN----SSGYKDLTGSFVTILK--Q 253
P Q + + K L D+ V + + + + + Y+ L V + + Q
Sbjct: 182 PEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQ 241
Query: 254 VVGGKLPVEFNYHSVPAPWLQIQLLRILG---LLGKDDQR----------TSELMYDVLD 300
VV + + +PW + L G DDQ+ T + + +L
Sbjct: 242 VVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMDPDHRLLI 301
Query: 301 ESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKAL 360
+ + + N A++ + I PKSE A I K + + L +
Sbjct: 302 RNTKPLLQSRNA--AVVMAVAQLYWHISPKSE-----AGIISKSL----VRLLRSNREVQ 350
Query: 361 TYVIQQDPTLALQHQMTIIECLD-----HPDP-IIKRETLELLYRITNAQNITVIVQKML 414
V+Q T+++Q + L DP +IK LE+L + N NI+ ++++
Sbjct: 351 YIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQ 410
Query: 415 EYLHQSKEEY--VIVNLVGKIA 434
Y+ +++ + +G+ A
Sbjct: 411 TYVKSQDKQFAAATIQTIGRCA 432
>gi|109134349 coatomer protein complex, subunit gamma 2 [Homo
sapiens]
Length = 871
Score = 47.0 bits (110), Expect = 1e-04
Identities = 92/542 (16%), Positives = 215/542 (39%), Gaps = 48/542 (8%)
Query: 49 KHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGY-DASFGYIHAIKLAQQ 107
+H E+ + QE T P L ++ + + L E G +A+ + +L Q
Sbjct: 20 QHLEKSAVLQEARIFNETPINPRRCLHILTKILYLLNQGEHFGTTEATEAFFAMTRLFQS 79
Query: 108 GNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIP 167
+ +R+ YL + S +++++ +++ KD+ V A+ + +I M+
Sbjct: 80 NDQTLRRMCYLTIKEMATISEDVIIV-TSSLTKDMTGKEDVYRGPAIRALCRITDGTMLQ 138
Query: 168 AVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFRKALCDRDVGVMAASLH 227
A+ ++ + V A+++ I+ + V+ + ++A ++ V +L
Sbjct: 139 AIERYMKQAIVDKVSSVSSSALVSSLHMMKISYDVVKRWINEAQEAASSDNIMVQYHALG 198
Query: 228 IYLRMIKENSSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLLGKD 287
+ + K + ++ K+ +F + + + L+RI L K+
Sbjct: 199 VLYHLRKND----------------RLAVSKMLNKFTKSGLKSQFAYCMLIRIASRLLKE 242
Query: 288 DQRTSEL-MYDVLDESLRRAELNHNVTYAILFECVHTVYSIYP-KSELLEKAAKCIGKFV 345
+ E ++D ++ LR N +++E + + + L A + F
Sbjct: 243 TEDGHESPLFDFIESCLR------NKHEMVIYEAASAIIHLPNCTARELAPAVSVLQLFC 296
Query: 346 LSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQN 405
SPK L+Y ++ L V + P+ + + + + I + L + + +
Sbjct: 297 SSPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLITDSNRSIATLAITTLLKTGSESS 356
Query: 406 ITVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTM-NAVFSVGGDVMHP 464
+ +++++ ++ + +E+ +V +V I+ L +KY ++ + + N + GG
Sbjct: 357 VDRLMKQISSFVSEISDEFKVV-VVQAISALCQKYPRKHSVMMTFLSNMLRDDGGFEYKR 415
Query: 465 DIPNNFLRLLAEGFDDETEDQQLRLYAVQSYLTLLDMENVFYPQRFLQVMSWVLGEYSYL 524
I + + ++ ++ E ++ L + ++ D E+ + L +L
Sbjct: 416 AIVDCIISIV----EENPESKEAGLAHLCEFIE--DCEHTVLATKIL-----------HL 458
Query: 525 LDKETPEEVIAKLYKLLMNDSVSSETKAWLIAAVTKLTSQAHSSNTVERLIHEFTISLDT 584
L KE P + Y + + V E +A AAV+ L + E L+ + L
Sbjct: 459 LGKEGPRTPVPSKYIRFIFNRVVLENEAVRAAAVSALAKFGAQN---ESLLPSILVLLQR 515
Query: 585 CM 586
CM
Sbjct: 516 CM 517
>gi|34482047 adaptor-related protein complex 3, beta 2 subunit [Homo
sapiens]
Length = 1082
Score = 44.7 bits (104), Expect = 5e-04
Identities = 37/155 (23%), Positives = 71/155 (45%), Gaps = 2/155 (1%)
Query: 63 LKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSL 122
LK + +LK+ E M R++ G +AS + +K N+ K++ Y+ +
Sbjct: 42 LKEMLDTNKDSLKL--EAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVR 99
Query: 123 FLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQHSKE 182
+ E +L LL ++T + L+ N + AL V+S I ++P ++ I++
Sbjct: 100 YAEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSP 159
Query: 183 IVRRKAVLALYKFHLIAPNQVQHIHIKFRKALCDR 217
VR+ A A+ K + + +Q + K L D+
Sbjct: 160 YVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADK 194
>gi|11559929 coatomer protein complex, subunit gamma 1 [Homo
sapiens]
Length = 874
Score = 42.0 bits (97), Expect = 0.003
Identities = 67/412 (16%), Positives = 169/412 (41%), Gaps = 30/412 (7%)
Query: 49 KHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGY-DASFGYIHAIKLAQQ 107
+H E+ + QE T P ++ + + + E LG +A+ + KL Q
Sbjct: 20 QHLEKSAVLQEARVFNETPINPRKCAHILTKILYLINQGEHLGTTEATEAFFAMTKLFQS 79
Query: 108 GNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIP 167
+ +R+ YL + + +++++ +++ KD+ A+ + QI M+
Sbjct: 80 NDPTLRRMCYLTIKEMSCIAEDVIIV-TSSLTKDMTGKEDNYRGPAVRALCQITDSTMLQ 138
Query: 168 AVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFRKALCDRDVGVMAASLH 227
A+ ++ + V A+++ + + V+ + ++A ++ V +L
Sbjct: 139 AIERYMKQAIVDKVPSVSSSALVSSLHLLKCSFDVVKRWVNEAQEAASSDNIMVQYHALG 198
Query: 228 IYLRMIKENSSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGL-LGK 286
+ + K + ++ K+ + H + +P+ ++R+ L +
Sbjct: 199 LLYHVRKND----------------RLAVNKMISKVTRHGLKSPFAYCMMIRVASKQLEE 242
Query: 287 DDQRTSELMYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKS-ELLEKAAKCIGKFV 345
+D ++D ++ LR N +++E + ++ S + L A + F
Sbjct: 243 EDGSRDSPLFDFIESCLR------NKHEMVVYEAASAIVNLPGCSAKELAPAVSVLQLFC 296
Query: 346 LSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQN 405
SPK L+Y ++ L V + P+ + + + + I + L + + +
Sbjct: 297 SSPKAALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIATLAITTLLKTGSESS 356
Query: 406 ITVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSV 457
I +++++ ++ + +E+ +V +V I+ L +KY +A MN +F++
Sbjct: 357 IDRLMKQISSFMSEISDEFKVV-VVQAISALCQKYPRKHA---VLMNFLFTM 404
>gi|19923599 calmin [Homo sapiens]
Length = 1002
Score = 38.1 bits (87), Expect = 0.048
Identities = 36/149 (24%), Positives = 67/149 (44%), Gaps = 6/149 (4%)
Query: 718 KKESKTGDESGALPVPQESIMENVDQAITKKDQSQVLTQSKEEKEKQL--LASSLFVGLG 775
++E+K D + + +EN+ + + + ++ K+EK K + + SSLFV G
Sbjct: 824 QRETKENDPMDSHQSQESPNLENIANPLEENVTKESISSKKKEKRKHVDHVESSLFVAPG 883
Query: 776 SESTINLLGKADTVSHKFRRKSKVKEAKSGETTSTHNMTCS---SFSSLSNVAYEDDYYS 832
S + + L + D+ + ++ ++ TH + S S+ L N A DD +
Sbjct: 884 SVQSSDDL-EEDSSDYSIPSRTSHSDSSIYLRRHTHRSSESDHFSYVQLRNAADLDDRRN 942
Query: 833 NTLHDTGDKELKKFSLTSELLDSESLTEL 861
L + + SL S S+SLT+L
Sbjct: 943 RILTRKANSSGEAMSLGSHSPQSDSLTQL 971
>gi|19923479 suppressor of fused [Homo sapiens]
Length = 484
Score = 37.7 bits (86), Expect = 0.063
Identities = 29/119 (24%), Positives = 56/119 (47%), Gaps = 12/119 (10%)
Query: 165 MIPAVLPLIEDKLQHSKEIVRRKAV-----LALYKFHLIAPNQVQHIHIKFRKALCDRDV 219
++P + P ++ L H + R+ ++ A+ LI Q++ +H+KF +++
Sbjct: 323 VLPPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKF-----NQES 377
Query: 220 GVMAASLHIYLRMIKENSSGYKDLTGSF-VTILKQVVGGKLPVEFNYHSVPAPWLQIQL 277
G + L + R++ YK +TG +T + V G E + ++ PWLQI L
Sbjct: 378 GAL-IPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILL 435
>gi|171184451 centrosome-associated protein 350 [Homo sapiens]
Length = 3117
Score = 35.4 bits (80), Expect = 0.31
Identities = 60/256 (23%), Positives = 96/256 (37%), Gaps = 34/256 (13%)
Query: 675 QSPAGISLGSDVSGNSAETGLKETNSLKLEGIKKLWGKEGYLPKKESKTGDESGALPVPQ 734
Q A ISLGS + S L E G L ++E GD+ G +
Sbjct: 968 QDKAKISLGSSIDSVSEGPLLSE----------------GSLSEEE---GDQDGQPLLKV 1008
Query: 735 ESIMENVDQAITKKDQSQVLTQSKEEKEKQLLASSLFVGLGSESTINLLGKADTVS---- 790
I++ + +++ + + + ++E EK L G S+ L K S
Sbjct: 1009 AEILKEKEFCPGERNSYEPIKEFQKEAEKFLPLFGHIGGTQSKGPWEELAKGSPHSVINI 1068
Query: 791 --HKFRRKSKVKEAKSGETTSTHNMTCSSFSSLSNVAYEDDYYSNTLHDTGDKELKKFSL 848
++ K E K TST ++ + LS V+YEDD+ S+ TG KK +L
Sbjct: 1069 FTKSYQLYGKGFEDKLDRGTSTSRPLNATATPLSGVSYEDDFVSSP--GTGTSTEKKSTL 1126
Query: 849 TSELLDSESLTELPLVEKFSYCSLSTPSLFANNNMEIFHPPQSTAASVAKESSLASSFLE 908
S + S+ S ++ QS A+S + SS +
Sbjct: 1127 EPHSTLSPQEDHSNRKSAYDPSSVDVTSQHSSG-------AQSAASSRSSTSSKGKKGKK 1179
Query: 909 ETTEYIHSNAMEVCNN 924
E TE++ S V N+
Sbjct: 1180 EKTEWLDSFTGNVQNS 1195
>gi|239754668 PREDICTED: mucin 12 [Homo sapiens]
Length = 1952
Score = 35.0 bits (79), Expect = 0.41
Identities = 41/174 (23%), Positives = 71/174 (40%), Gaps = 26/174 (14%)
Query: 762 EKQLLASSLFVGLGSESTINLLGKADTVSHKFRRKSKVKEAKSGETTS-------THNMT 814
E L +++ GL ++STI L + + S + SGE TS TH
Sbjct: 1339 ETTLASTATTPGLSAKSTI-LYSSSRSPDQTLSPASMTSSSISGEPTSLYSQAESTHTTA 1397
Query: 815 CSSFSSLSNVAYEDDYYSNTLHDTGDKELKKFSLTSELLDSESLTELPLVEKFSYCSLST 874
+ ++ S ++ E S T H K T L S+T ++F+ T
Sbjct: 1398 FPASTTTSGLSQE----STTFHS-------KPGSTETTLSPGSITTSSFAQEFT-----T 1441
Query: 875 PSLFANNNMEIFHPPQSTAASVAKESSL--ASSFLEETTEYIHSNAMEVCNNET 926
P + + P +T +++ES+ +S ETT + HSN M + + ++
Sbjct: 1442 PHSQPGSALSTVSPASTTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQS 1495
>gi|89026265 PREDICTED: mucin 12 [Homo sapiens]
Length = 978
Score = 35.0 bits (79), Expect = 0.41
Identities = 41/174 (23%), Positives = 71/174 (40%), Gaps = 26/174 (14%)
Query: 762 EKQLLASSLFVGLGSESTINLLGKADTVSHKFRRKSKVKEAKSGETTS-------THNMT 814
E L +++ GL ++STI L + + S + SGE TS TH
Sbjct: 368 ETTLASTTTTPGLSAKSTI-LYSSSRSPDQTLSPASMTSSSISGEPTSLYSQAESTHTTA 426
Query: 815 CSSFSSLSNVAYEDDYYSNTLHDTGDKELKKFSLTSELLDSESLTELPLVEKFSYCSLST 874
+ ++ S ++ E S T H K T L S+T ++F+ T
Sbjct: 427 FPASTTTSGLSQE----STTFHS-------KPGSTETTLSPGSITTSSFAQEFT-----T 470
Query: 875 PSLFANNNMEIFHPPQSTAASVAKESSL--ASSFLEETTEYIHSNAMEVCNNET 926
P + + P +T +++ES+ +S ETT + HSN M + + ++
Sbjct: 471 PHSQPGSALSTVSPASTTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQS 524
>gi|239743293 PREDICTED: mucin 12 [Homo sapiens]
Length = 5478
Score = 35.0 bits (79), Expect = 0.41
Identities = 41/174 (23%), Positives = 71/174 (40%), Gaps = 26/174 (14%)
Query: 762 EKQLLASSLFVGLGSESTINLLGKADTVSHKFRRKSKVKEAKSGETTS-------THNMT 814
E L +++ GL ++STI L + + S + SGE TS TH
Sbjct: 4865 ETTLASTATTPGLSAKSTI-LYSSSRSPDQTLSPASMTSSSISGEPTSLYSQAESTHTTA 4923
Query: 815 CSSFSSLSNVAYEDDYYSNTLHDTGDKELKKFSLTSELLDSESLTELPLVEKFSYCSLST 874
+ ++ S ++ E S T H K T L S+T ++F+ T
Sbjct: 4924 FPASTTTSGLSQE----STTFHS-------KPGSTETTLSPGSITTSSFAQEFT-----T 4967
Query: 875 PSLFANNNMEIFHPPQSTAASVAKESSL--ASSFLEETTEYIHSNAMEVCNNET 926
P + + P +T +++ES+ +S ETT + HSN M + + ++
Sbjct: 4968 PHSQPGSALSTVSPASTTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQS 5021
>gi|224593278 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Homo
sapiens]
Length = 796
Score = 34.7 bits (78), Expect = 0.53
Identities = 41/160 (25%), Positives = 67/160 (41%), Gaps = 23/160 (14%)
Query: 646 RQEEKLSQEKVLNFEPYGLSFSSSGFTGRQSPAGISLGSDVSGNSAETGLKETNSLKLEG 705
R+++ L + + +F P F+ T S A + S + A T L E K+
Sbjct: 69 RRQKALGKNRSADFNP-DFVFTEKEGTYDGSWALADVMSQLKKKRAATTLDEKIE-KVRK 126
Query: 706 IKKLWGKEGYLPKKESKTGDESGALPVPQESIMENVDQAITKKDQSQVLTQSKEEKEKQL 765
+K KE K E + + G+ P QE + EN D+ ++ + S+ S +E
Sbjct: 127 KRKTEDKEAKSGKLEKEKEAKEGSEPKEQEDLQEN-DEEGSEDEASETDYSSADE----- 180
Query: 766 LASSLFVGLGSESTINLLGKADTVSHKFRRKSKVKEAKSG 805
N+L KADT+ K R+K K K ++G
Sbjct: 181 ---------------NILTKADTLKVKDRKKKKKKGQEAG 205
>gi|23510381 transportin 1 isoform 2 [Homo sapiens]
Length = 890
Score = 33.5 bits (75), Expect = 1.2
Identities = 13/40 (32%), Positives = 27/40 (67%)
Query: 153 ALTVVSQIFPCEMIPAVLPLIEDKLQHSKEIVRRKAVLAL 192
AL V++ ++ E++P +LPL+++ L H + +V+ +L L
Sbjct: 382 ALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVL 421
>gi|133925811 transportin 1 isoform 1 [Homo sapiens]
Length = 898
Score = 33.5 bits (75), Expect = 1.2
Identities = 13/40 (32%), Positives = 27/40 (67%)
Query: 153 ALTVVSQIFPCEMIPAVLPLIEDKLQHSKEIVRRKAVLAL 192
AL V++ ++ E++P +LPL+++ L H + +V+ +L L
Sbjct: 390 ALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVL 429
>gi|7706254 NOP58 ribonucleoprotein homolog [Homo sapiens]
Length = 529
Score = 33.5 bits (75), Expect = 1.2
Identities = 36/157 (22%), Positives = 63/157 (40%), Gaps = 26/157 (16%)
Query: 680 ISLGSDVSGNSAETGLKETNSLKLE---------GIKKLWGK-------EGYLPKKESKT 723
+++ D G + + + N KLE GI+K+ G E Y K E KT
Sbjct: 368 LAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKT 427
Query: 724 GDESGALPVPQESIMENVDQAITKKDQSQVLTQSKEEKEKQLLASSLFVGLGSESTINLL 783
D SG +P S ++Q D+ +T+ K +K K + V + E +
Sbjct: 428 YDPSGDSTLPTCSKKRKIEQV----DKEDEITEKKAKKAK------IKVKVEEEEEEKVA 477
Query: 784 GKADTVSHKFRRKSKVKEAKSGETTSTHNMTCSSFSS 820
+ +T K +++ K K K + T ++ +S
Sbjct: 478 EEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIAS 514
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,172,830
Number of Sequences: 37866
Number of extensions: 1718256
Number of successful extensions: 5108
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 4988
Number of HSP's gapped (non-prelim): 139
length of query: 1137
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1024
effective length of database: 13,968,660
effective search space: 14303907840
effective search space used: 14303907840
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.