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Search of human proteins with 34335134
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34335134 SEC13 protein isoform 1 [Homo sapiens]
(322 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34335134 SEC13 protein isoform 1 [Homo sapiens] 686 0.0
gi|210032390 SEC13 protein isoform 2 [Homo sapiens] 659 0.0
gi|61743971 sec13-like protein isoform 1 [Homo sapiens] 159 4e-39
gi|61743969 sec13-like protein isoform 2 [Homo sapiens] 159 4e-39
gi|4757988 WD repeat domain 39 [Homo sapiens] 103 2e-22
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 72 5e-13
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 69 7e-12
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 69 7e-12
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 67 2e-11
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 65 1e-10
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 65 1e-10
gi|19913367 transducin beta-like 1Y [Homo sapiens] 63 4e-10
gi|19913365 transducin beta-like 1Y [Homo sapiens] 63 4e-10
gi|15150805 transducin beta-like 1Y [Homo sapiens] 63 4e-10
gi|19913369 transducin beta-like 3 [Homo sapiens] 60 3e-09
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 59 4e-09
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 57 3e-08
gi|14150171 THO complex 3 [Homo sapiens] 56 4e-08
gi|23199987 WD repeat domain 5B [Homo sapiens] 55 8e-08
gi|26665869 WD repeat domain 51B [Homo sapiens] 54 2e-07
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 53 4e-07
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens] 53 4e-07
gi|223029510 echinoderm microtubule associated protein like 4 is... 53 4e-07
gi|19923497 echinoderm microtubule associated protein like 4 iso... 53 4e-07
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 53 4e-07
gi|89026256 PREDICTED: similar to actin related protein 2/3 comp... 52 5e-07
gi|5031601 actin related protein 2/3 complex subunit 1B [Homo sa... 52 5e-07
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 52 9e-07
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa... 51 1e-06
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa... 51 1e-06
>gi|34335134 SEC13 protein isoform 1 [Homo sapiens]
Length = 322
Score = 686 bits (1769), Expect = 0.0
Identities = 322/322 (100%), Positives = 322/322 (100%)
Query: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60
MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV
Sbjct: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60
Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLIL 120
WQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLIL
Sbjct: 61 WQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLIL 120
Query: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIK 180
ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIK
Sbjct: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIK 180
Query: 181 RFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV 240
RFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV
Sbjct: 181 RFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV 240
Query: 241 FIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI 300
FIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI
Sbjct: 241 FIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI 300
Query: 301 SDVNKGQGSVSASVTEGQQNEQ 322
SDVNKGQGSVSASVTEGQQNEQ
Sbjct: 301 SDVNKGQGSVSASVTEGQQNEQ 322
>gi|210032390 SEC13 protein isoform 2 [Homo sapiens]
Length = 308
Score = 659 bits (1699), Expect = 0.0
Identities = 308/308 (100%), Positives = 308/308 (100%)
Query: 15 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 74
MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL
Sbjct: 1 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 60
Query: 75 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 134
ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY
Sbjct: 61 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120
Query: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 194
TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW
Sbjct: 121 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 180
Query: 195 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 254
KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS
Sbjct: 181 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 240
Query: 255 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV 314
PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV
Sbjct: 241 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV 300
Query: 315 TEGQQNEQ 322
TEGQQNEQ
Sbjct: 301 TEGQQNEQ 308
>gi|61743971 sec13-like protein isoform 1 [Homo sapiens]
Length = 421
Score = 159 bits (401), Expect = 4e-39
Identities = 106/349 (30%), Positives = 162/349 (46%), Gaps = 47/349 (13%)
Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQ 62
V ++ H+D+IHD D++G R+ATCSSD+SVK++D G A + H G VW+
Sbjct: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62
Query: 63 VAWAHPMYGNILASCSYDRKVIIWREENGT----------WEKSHEHAGHDSSVNSVCWA 112
V WAHP +G +LASCS+DR +W E G W K +SV V +A
Sbjct: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFA 122
Query: 113 PHDYGLILACGSSDGAISLL---TYTGEGQWEVKKINNAHTIGCNAVSW--------APA 161
P GL+LA S+DG + + QW ++ + + C+ +SW +P
Sbjct: 123 PKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQH-EISCKLSCSCISWNPSSSRAHSPM 181
Query: 162 VVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWA 221
+ GS P+ I + E ++ + + L +D V D+A+A
Sbjct: 182 IAVGSDDSSPNAMAKVQIFEY-------------NENTRKYAKAETLMTVTDPVHDIAFA 228
Query: 222 PSIGLPTSTIASCSQDGRVFIW------TCDDASSNTWSPKLLHKF---NDVVWHVSWSI 272
P++G +A ++D R+F + ++ +F N VW VSW+I
Sbjct: 229 PNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNI 288
Query: 273 TANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGS-VSASVTEGQQN 320
T +LA SG D V LWK + W C + + KG GS V+ S +G N
Sbjct: 289 TGTVLASSGDDGCVRLWKANYMDNWKC-TGILKGNGSPVNGSSQQGTSN 336
>gi|61743969 sec13-like protein isoform 2 [Homo sapiens]
Length = 360
Score = 159 bits (401), Expect = 4e-39
Identities = 106/349 (30%), Positives = 162/349 (46%), Gaps = 47/349 (13%)
Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQ 62
V ++ H+D+IHD D++G R+ATCSSD+SVK++D G A + H G VW+
Sbjct: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62
Query: 63 VAWAHPMYGNILASCSYDRKVIIWREENGT----------WEKSHEHAGHDSSVNSVCWA 112
V WAHP +G +LASCS+DR +W E G W K +SV V +A
Sbjct: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFA 122
Query: 113 PHDYGLILACGSSDGAISLL---TYTGEGQWEVKKINNAHTIGCNAVSW--------APA 161
P GL+LA S+DG + + QW ++ + + C+ +SW +P
Sbjct: 123 PKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQH-EISCKLSCSCISWNPSSSRAHSPM 181
Query: 162 VVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWA 221
+ GS P+ I + E ++ + + L +D V D+A+A
Sbjct: 182 IAVGSDDSSPNAMAKVQIFEY-------------NENTRKYAKAETLMTVTDPVHDIAFA 228
Query: 222 PSIGLPTSTIASCSQDGRVFIW------TCDDASSNTWSPKLLHKF---NDVVWHVSWSI 272
P++G +A ++D R+F + ++ +F N VW VSW+I
Sbjct: 229 PNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNI 288
Query: 273 TANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGS-VSASVTEGQQN 320
T +LA SG D V LWK + W C + + KG GS V+ S +G N
Sbjct: 289 TGTVLASSGDDGCVRLWKANYMDNWKC-TGILKGNGSPVNGSSQQGTSN 336
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 103 bits (258), Expect = 2e-22
Identities = 83/280 (29%), Positives = 126/280 (45%), Gaps = 39/280 (13%)
Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADL-RGHEGPVWQVAWAHPMYGNILASCSYDRKV 83
GT LA+C DR ++I+ I + L GH+ V +VAW+ GN LAS S+D
Sbjct: 28 GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSP--CGNYLASASFDATT 85
Query: 84 IIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 143
IW++ +E GH++ V SV WAP G +LA S D ++ + E ++E
Sbjct: 86 CIWKKNQDDFECVTTLEGHENEVKSVAWAPS--GNLLATCSRDKSVWVWEVDEEDEYECV 143
Query: 144 KINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWK 203
+ N+HT V W HPS + AS D+ +KL++EEED W
Sbjct: 144 SVLNSHTQDVKHVVW-----------HPSQE------LLASASYDDTVKLYREEED-DWV 185
Query: 204 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW-----------TCDDASSNT 252
LE H V +A+ PS +ASCS D V IW C + +
Sbjct: 186 CCATLEGHESTVWSLAFDPS----GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSW 241
Query: 253 WSPKLLHKFND-VVWHVSWSITANILAVSGGDNKVTLWKE 291
L F+ ++ ++W LA + GD+ + +++E
Sbjct: 242 KCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQE 281
Score = 75.1 bits (183), Expect = 8e-14
Identities = 66/251 (26%), Positives = 113/251 (45%), Gaps = 32/251 (12%)
Query: 48 ILIADLRGH-EGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWE-KSHEHAGHDSS 105
+L+ + H + W +AW +P G +LASC DR++ IW E +W KS GH +
Sbjct: 6 VLLGRVPAHPDSRCWFLAW-NPA-GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT 63
Query: 106 VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPG 165
V V W+P G LA S D A + + + +E H +V+WAP+ G
Sbjct: 64 VRKVAWSP--CGNYLASASFD-ATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPS---G 117
Query: 166 SLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIG 225
+L+ A+ D + +W+ +E+ +++ L +H+ V+ V W PS
Sbjct: 118 NLL--------------ATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE 163
Query: 226 LPTSTIASCSQDGRVFIWTCDDASSNTW-SPKLLHKFNDVVWHVSWSITANILAVSGGDN 284
L +AS S D V ++ ++ + W L VW +++ + LA D
Sbjct: 164 L----LASASYDDTVKLYREEE---DDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDR 216
Query: 285 KVTLWKESVDG 295
V +W++ + G
Sbjct: 217 TVRIWRQYLPG 227
Score = 69.7 bits (169), Expect = 3e-12
Identities = 82/310 (26%), Positives = 116/310 (37%), Gaps = 56/310 (18%)
Query: 6 NTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAW 65
+ + H+ + G LA+ S D + I+ + L GHE V VAW
Sbjct: 54 SVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAW 113
Query: 66 AHPMYGNILASCSYDRKVIIWR-EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGS 124
A GN+LA+CS D+ V +W +E +E H V V W P +LA S
Sbjct: 114 APS--GNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE--LLASAS 169
Query: 125 SDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFAS 184
D + L E W + A G + W SL PSGQ R AS
Sbjct: 170 YDDTVKLYR-EEEDDW----VCCATLEGHESTVW-------SLAFDPSGQ------RLAS 211
Query: 185 GGCDNLIKLWKE------------EEDGQWKEEQKLEA-HSDWVRDVAWAPSIGLPTSTI 231
D +++W++ D WK L HS + D+AW G +
Sbjct: 212 CSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTG---ALA 268
Query: 232 ASCSQDG-RVFIWTCDDASSNTWSPKL-----LHK-----FNDVVWHVSWSITANILAVS 280
+C D RVF +D +S+ P LH+ N V W+ +LA
Sbjct: 269 TACGDDAIRVF---QEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPK---EPGLLASC 322
Query: 281 GGDNKVTLWK 290
D +V WK
Sbjct: 323 SDDGEVAFWK 332
Score = 54.7 bits (130), Expect = 1e-07
Identities = 39/143 (27%), Positives = 60/143 (41%), Gaps = 22/143 (15%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI-------------LIADLRG-HE 57
HE + D G RLA+CS DR+V+I+ G I L G H
Sbjct: 193 HESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHS 252
Query: 58 GPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEK------SHEHAGHDSSVNSVCW 111
++ +AW + G + +C D + + N ++ +H H H VN V W
Sbjct: 253 RTIYDIAWCQ-LTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAW 311
Query: 112 APHDYGLILACGSSDGAISLLTY 134
P + GL+ +C S DG ++ Y
Sbjct: 312 NPKEPGLLASC-SDDGEVAFWKY 333
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 10/124 (8%)
Query: 183 ASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242
AS G D I++W E D + E H VR VAW+P + +AS S D I
Sbjct: 32 ASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPC----GNYLASASFDATTCI 87
Query: 243 W--TCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI 300
W DD T L + V V+W+ + N+LA D V +W+ + ++ C+
Sbjct: 88 WKKNQDDFECVT----TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143
Query: 301 SDVN 304
S +N
Sbjct: 144 SVLN 147
Score = 35.8 bits (81), Expect = 0.053
Identities = 13/41 (31%), Positives = 24/41 (58%), Gaps = 1/41 (2%)
Query: 266 WHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306
W ++W+ +LA GGD ++ +W D W+C S +++G
Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGD-SWICKSVLSEG 59
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 72.4 bits (176), Expect = 5e-13
Identities = 73/283 (25%), Positives = 121/283 (42%), Gaps = 27/283 (9%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71
H D + D D+ G LA+CS+D ++K++D + G I + GH+ V VA G
Sbjct: 149 HTDSVQDISFDHSGKLLASCSADMTIKLWDFQ--GFECIRTMHGHDHNVSSVAIM--PNG 204
Query: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131
+ + S S D+ + +W + G K+ GH V V P+ G ++A S+D + +
Sbjct: 205 DHIVSASRDKTIKMWEVQTGYCVKT--FTGHREWVRMV--RPNQDGTLIASCSNDQTVRV 260
Query: 132 -LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKR---FASGGC 187
+ T E + E+++ + H + C +SWAP S+ + + K SG
Sbjct: 261 WVVATKECKAELRE--HEHVVEC--ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSR 316
Query: 188 DNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247
D IK+W + G L H +WVR V + I SC+ D + +W
Sbjct: 317 DKTIKMW-DVSTGMCL--MTLVGHDNWVRGVLFHSG----GKFILSCADDKTLRVWD--- 366
Query: 248 ASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290
N K L+ V + + TA + D V +W+
Sbjct: 367 -YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 54.3 bits (129), Expect = 1e-07
Identities = 60/228 (26%), Positives = 98/228 (42%), Gaps = 37/228 (16%)
Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 112
L GH PV +V + HP++ +++ S S D + +W E G +E++ + GH SV + +
Sbjct: 104 LSGHRSPVTRVIF-HPVF-SVMVSASEDATIKVWDYETGDFERTLK--GHTDSVQDISF- 158
Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPS 172
G +LA S+D I L + G +E + + H ++V A++P DH
Sbjct: 159 -DHSGKLLASCSADMTIKLWDFQG---FECIRTMHGHDHNVSSV----AIMPNG--DH-- 206
Query: 173 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232
S D IK+W E + G + H +WVR V + IA
Sbjct: 207 ---------IVSASRDKTIKMW-EVQTGYC--VKTFTGHREWVRMV----RPNQDGTLIA 250
Query: 233 SCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVS 280
SCS D V +W L + VV +SW+ ++ ++S
Sbjct: 251 SCSNDQTVRVWVVATKECKA----ELREHEHVVECISWAPESSYSSIS 294
Score = 40.8 bits (94), Expect = 0.002
Identities = 45/179 (25%), Positives = 77/179 (43%), Gaps = 30/179 (16%)
Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA-HP 68
T H + + + + GT +A+CS+D++V+++ V + A+LR HE V ++WA
Sbjct: 231 TGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVAT--KECKAELREHEHVVECISWAPES 288
Query: 69 MYGNI-----------------LASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCW 111
Y +I L S S D+ + +W G + GHD+ V V +
Sbjct: 289 SYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT--LVGHDNWVRGVLF 346
Query: 112 APHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSW---APAVVPGSL 167
H G + + D + + Y + K NAH ++ + AP VV GS+
Sbjct: 347 --HSGGKFILSCADDKTLRVWDYKNK---RCMKTLNAHEHFVTSLDFHKTAPYVVTGSV 400
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 68.6 bits (166), Expect = 7e-12
Identities = 69/295 (23%), Positives = 109/295 (36%), Gaps = 57/295 (19%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71
H D ++ A G R+A+C +D+++++F G ++L +++ HE V + A
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEV--LCCAFSTDD 669
Query: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131
+A+CS D+KV IW G E H + H VN + + L+LA GSSD + L
Sbjct: 670 RFIATCSVDKKVKIWNSMTG--ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 727
Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 191
Q E + HT N ++P K AS D +
Sbjct: 728 WDL---NQKECRNTMFGHTNSVNHCRFSPD-----------------DKLLASCSADGTL 767
Query: 192 KLWKEEEDGQWKE----------EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241
KLW + K E E V+ +W+ + ++F
Sbjct: 768 KLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD-----GARIMVAAKNKIF 822
Query: 242 IWTCDDASSNTWSPKLLHKFNDVVWHVSW------SITANILAVSGGDNKVTLWK 290
+W D S K D H+SW S + S D + LW+
Sbjct: 823 LWNTDSRS----------KVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 68.6 bits (166), Expect = 7e-12
Identities = 69/295 (23%), Positives = 109/295 (36%), Gaps = 57/295 (19%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71
H D ++ A G R+A+C +D+++++F G ++L +++ HE V + A
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEV--LCCAFSTDD 658
Query: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131
+A+CS D+KV IW G E H + H VN + + L+LA GSSD + L
Sbjct: 659 RFIATCSVDKKVKIWNSMTG--ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 716
Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 191
Q E + HT N ++P K AS D +
Sbjct: 717 WDL---NQKECRNTMFGHTNSVNHCRFSPD-----------------DKLLASCSADGTL 756
Query: 192 KLWKEEEDGQWKE----------EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241
KLW + K E E V+ +W+ + ++F
Sbjct: 757 KLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD-----GARIMVAAKNKIF 811
Query: 242 IWTCDDASSNTWSPKLLHKFNDVVWHVSW------SITANILAVSGGDNKVTLWK 290
+W D S K D H+SW S + S D + LW+
Sbjct: 812 LWNTDSRS----------KVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 67.4 bits (163), Expect = 2e-11
Identities = 71/284 (25%), Positives = 115/284 (40%), Gaps = 38/284 (13%)
Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69
+ HE ++ + G+ LA+ DR + +++V G A L+GH G V ++ +
Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD- 120
Query: 70 YGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI 129
G++L S S D+ V +W E G E+ GH S VNS C+ ++ GS DG +
Sbjct: 121 -GSMLFSASTDKTVAVWDSETG--ERVKRLKGHTSFVNS-CYPARRGPQLVCTGSDDGTV 176
Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDN 189
L W+++K T AV D + SGG DN
Sbjct: 177 KL--------WDIRKKAAIQTF--QNTYQVLAVTFNDTSD-----------QIISGGIDN 215
Query: 190 LIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249
IK+W ++ K + H+D V + S+ S + S + D V +W +
Sbjct: 216 DIKVWDLRQN---KLTYTMRGHADSVTGL----SLSSEGSYLLSNAMDNTVRVWDVRPFA 268
Query: 250 SNTWSPKL----LHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289
K+ +H F + SWS + +A D V +W
Sbjct: 269 PKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312
Score = 35.0 bits (79), Expect = 0.090
Identities = 33/134 (24%), Positives = 62/134 (46%), Gaps = 16/134 (11%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGG------QILIADLRGHEGPVWQVAW 65
H D + + G+ L + + D +V+++DVR +I ++ E + + +W
Sbjct: 234 HADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSW 293
Query: 66 AHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSS 125
+ G+ +A+ S DR V +W + + ++ GH S+N V + P + I+ SS
Sbjct: 294 SPD--GSKIAAGSADRFVYVW--DTTSRRILYKLPGHAGSINEVAFHPDE--PIIISASS 347
Query: 126 DGAISLLTYTGEGQ 139
D + Y GE Q
Sbjct: 348 DKRL----YMGEIQ 357
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 64.7 bits (156), Expect = 1e-10
Identities = 50/183 (27%), Positives = 78/183 (42%), Gaps = 26/183 (14%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71
H D ++ A G R+A+C +D+++++F G ++L +++ HE V + A
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEV--LCCAFSTDD 669
Query: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131
+A+CS D+KV IW G E H + H VN + + L+LA GSSD + L
Sbjct: 670 RFIATCSVDKKVKIWNSMTG--ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 727
Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 191
Q E + HT N ++P K AS D +
Sbjct: 728 WDL---NQKECRNTMFGHTNSVNHCRFSPD-----------------DKLLASCSADGTL 767
Query: 192 KLW 194
KLW
Sbjct: 768 KLW 770
Score = 33.1 bits (74), Expect = 0.34
Identities = 31/115 (26%), Positives = 53/115 (46%), Gaps = 19/115 (16%)
Query: 180 KRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239
+R AS G D ++++K E + E ++AH D V A++ IA+CS D +
Sbjct: 628 QRIASCGADKTLQVFKAETGEKLLE---IKAHEDEVLCCAFSTD----DRFIATCSVDKK 680
Query: 240 VFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITAN-----ILAVSGGDNKVTLW 289
V IW N+ + +L+H +++ V+ N +LA D + LW
Sbjct: 681 VKIW-------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLW 728
Score = 32.7 bits (73), Expect = 0.44
Identities = 46/199 (23%), Positives = 80/199 (40%), Gaps = 35/199 (17%)
Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 112
+R H V+ ++ G +ASC D+ + +++ E G EK E H+ V +C A
Sbjct: 611 VRPHTDAVYHACFSED--GQRIASCGADKTLQVFKAETG--EKLLEIKAHEDEV--LCCA 664
Query: 113 PHDYGLILACGSSDGAISLL-TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHP 171
+A S D + + + TGE + + H+ N + +
Sbjct: 665 FSTDDRFIATCSVDKKVKIWNSMTGE----LVHTYDEHSEQVNCCHFTNS---------- 710
Query: 172 SGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE-EQKLEAHSDWVRDVAWAPSIGLPTST 230
++ A+G D +KLW D KE + H++ V ++P L
Sbjct: 711 -----SHHLLLATGSSDCFLKLW----DLNQKECRNTMFGHTNSVNHCRFSPDDKL---- 757
Query: 231 IASCSQDGRVFIWTCDDAS 249
+ASCS DG + +W A+
Sbjct: 758 LASCSADGTLKLWDATSAN 776
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 64.7 bits (156), Expect = 1e-10
Identities = 50/183 (27%), Positives = 78/183 (42%), Gaps = 26/183 (14%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71
H D ++ A G R+A+C +D+++++F G ++L +++ HE V + A
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEV--LCCAFSTDD 658
Query: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131
+A+CS D+KV IW G E H + H VN + + L+LA GSSD + L
Sbjct: 659 RFIATCSVDKKVKIWNSMTG--ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 716
Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 191
Q E + HT N ++P K AS D +
Sbjct: 717 WDL---NQKECRNTMFGHTNSVNHCRFSPD-----------------DKLLASCSADGTL 756
Query: 192 KLW 194
KLW
Sbjct: 757 KLW 759
Score = 33.1 bits (74), Expect = 0.34
Identities = 31/115 (26%), Positives = 53/115 (46%), Gaps = 19/115 (16%)
Query: 180 KRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239
+R AS G D ++++K E + E ++AH D V A++ IA+CS D +
Sbjct: 617 QRIASCGADKTLQVFKAETGEKLLE---IKAHEDEVLCCAFSTD----DRFIATCSVDKK 669
Query: 240 VFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITAN-----ILAVSGGDNKVTLW 289
V IW N+ + +L+H +++ V+ N +LA D + LW
Sbjct: 670 VKIW-------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLW 717
Score = 32.7 bits (73), Expect = 0.44
Identities = 46/199 (23%), Positives = 80/199 (40%), Gaps = 35/199 (17%)
Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 112
+R H V+ ++ G +ASC D+ + +++ E G EK E H+ V +C A
Sbjct: 600 VRPHTDAVYHACFSED--GQRIASCGADKTLQVFKAETG--EKLLEIKAHEDEV--LCCA 653
Query: 113 PHDYGLILACGSSDGAISLL-TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHP 171
+A S D + + + TGE + + H+ N + +
Sbjct: 654 FSTDDRFIATCSVDKKVKIWNSMTGE----LVHTYDEHSEQVNCCHFTNS---------- 699
Query: 172 SGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE-EQKLEAHSDWVRDVAWAPSIGLPTST 230
++ A+G D +KLW D KE + H++ V ++P L
Sbjct: 700 -----SHHLLLATGSSDCFLKLW----DLNQKECRNTMFGHTNSVNHCRFSPDDKL---- 746
Query: 231 IASCSQDGRVFIWTCDDAS 249
+ASCS DG + +W A+
Sbjct: 747 LASCSADGTLKLWDATSAN 765
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 62.8 bits (151), Expect = 4e-10
Identities = 74/308 (24%), Positives = 114/308 (37%), Gaps = 83/308 (26%)
Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84
GT LA S D +I+ NG L + L H+GP++ + W GN + S D+ I
Sbjct: 247 GTLLAMGSYDGFARIW-TENGN--LASTLGQHKGPIFALKWNKK--GNYVLSAGVDKTTI 301
Query: 85 IWREENGT----------------WEKSHEHA-----------------------GHDSS 105
IW G W+ + A GH +
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361
Query: 106 VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNA-----VSWAP 160
VN++ W P G++LA S D + + W +K+ H + ++ + W+P
Sbjct: 362 VNAIKWDPS--GMLLASCSDDMTLKI--------WSMKQDACVHDLQAHSKEIYTIKWSP 411
Query: 161 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 220
P+ PN AS D+ ++LW E Q L H + V VA+
Sbjct: 412 T--------GPATSNPNSSIMLASASFDSTVRLWDVE---QGVCTHTLMKHQEPVYSVAF 460
Query: 221 APSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDV--VWHVSWSITANILA 278
+P +AS S D V IW NT S L+H + ++ V W+ + +
Sbjct: 461 SPD----GKYLASGSFDKYVHIW-------NTQSGSLVHSYQGTGGIFEVCWNARGDKVG 509
Query: 279 VSGGDNKV 286
S D V
Sbjct: 510 ASASDGSV 517
Score = 52.4 bits (124), Expect = 5e-07
Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 13/122 (10%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA----- 66
H + ++ + D G LA+CS D ++KI+ ++ + DL+ H ++ + W+
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA--CVHDLQAHSKEIYTIKWSPTGPA 415
Query: 67 --HPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGS 124
+P +LAS S+D V +W E G +H H V SV ++P G LA GS
Sbjct: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVC--THTLMKHQEPVYSVAFSPD--GKYLASGS 471
Query: 125 SD 126
D
Sbjct: 472 FD 473
Score = 51.2 bits (121), Expect = 1e-06
Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 9/105 (8%)
Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 87
LA+ S D +V+++DV G + L H+ PV+ VA++ G LAS S+D+ V IW
Sbjct: 425 LASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPD--GKYLASGSFDKYVHIWN 480
Query: 88 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132
++G+ S++ G + VCW + G + +SDG++ +L
Sbjct: 481 TQSGSLVHSYQGTG---GIFEVCW--NARGDKVGASASDGSVCVL 520
Score = 46.2 bits (108), Expect = 4e-05
Identities = 80/323 (24%), Positives = 121/323 (37%), Gaps = 56/323 (17%)
Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVR---NGGQILIADLR------GHE 57
TV HE + + LA+ S D + +I+++ NGG + LR GH+
Sbjct: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHD 231
Query: 58 GP----VWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAP 113
P V + W G +LA SYD IW E +H G + ++ W
Sbjct: 232 VPSNKDVTSLDWNSD--GTLLAMGSYDGFARIWTENGNLASTLGQHKG---PIFALKWNK 286
Query: 114 HDYGLILACGSSDGAISLLTYTGEGQ----------WEVKKINNAHTIGCNAVSWAPAVV 163
+L+ G I +TGE + +V NN C+
Sbjct: 287 KG-NYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCR 345
Query: 164 PGSLIDHP------SGQKPNYIKRFASG----GC--DNLIKLWKEEEDGQWKEEQKLEAH 211
G DHP + N IK SG C D +K+W ++D + L+AH
Sbjct: 346 LG--CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHD---LQAH 400
Query: 212 SDWVRDVAWA---PSIGLPTSTI--ASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVW 266
S + + W+ P+ P S+I AS S D V +W + L K + V+
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCT----HTLMKHQEPVY 456
Query: 267 HVSWSITANILAVSGGDNKVTLW 289
V++S LA D V +W
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIW 479
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 62.8 bits (151), Expect = 4e-10
Identities = 74/308 (24%), Positives = 114/308 (37%), Gaps = 83/308 (26%)
Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84
GT LA S D +I+ NG L + L H+GP++ + W GN + S D+ I
Sbjct: 247 GTLLAMGSYDGFARIW-TENGN--LASTLGQHKGPIFALKWNKK--GNYVLSAGVDKTTI 301
Query: 85 IWREENGT----------------WEKSHEHA-----------------------GHDSS 105
IW G W+ + A GH +
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361
Query: 106 VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNA-----VSWAP 160
VN++ W P G++LA S D + + W +K+ H + ++ + W+P
Sbjct: 362 VNAIKWDPS--GMLLASCSDDMTLKI--------WSMKQDACVHDLQAHSKEIYTIKWSP 411
Query: 161 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 220
P+ PN AS D+ ++LW E Q L H + V VA+
Sbjct: 412 T--------GPATSNPNSSIMLASASFDSTVRLWDVE---QGVCTHTLMKHQEPVYSVAF 460
Query: 221 APSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDV--VWHVSWSITANILA 278
+P +AS S D V IW NT S L+H + ++ V W+ + +
Sbjct: 461 SPD----GKYLASGSFDKYVHIW-------NTQSGSLVHSYQGTGGIFEVCWNARGDKVG 509
Query: 279 VSGGDNKV 286
S D V
Sbjct: 510 ASASDGSV 517
Score = 52.4 bits (124), Expect = 5e-07
Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 13/122 (10%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA----- 66
H + ++ + D G LA+CS D ++KI+ ++ + DL+ H ++ + W+
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA--CVHDLQAHSKEIYTIKWSPTGPA 415
Query: 67 --HPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGS 124
+P +LAS S+D V +W E G +H H V SV ++P G LA GS
Sbjct: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVC--THTLMKHQEPVYSVAFSPD--GKYLASGS 471
Query: 125 SD 126
D
Sbjct: 472 FD 473
Score = 51.2 bits (121), Expect = 1e-06
Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 9/105 (8%)
Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 87
LA+ S D +V+++DV G + L H+ PV+ VA++ G LAS S+D+ V IW
Sbjct: 425 LASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPD--GKYLASGSFDKYVHIWN 480
Query: 88 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132
++G+ S++ G + VCW + G + +SDG++ +L
Sbjct: 481 TQSGSLVHSYQGTG---GIFEVCW--NARGDKVGASASDGSVCVL 520
Score = 46.2 bits (108), Expect = 4e-05
Identities = 80/323 (24%), Positives = 121/323 (37%), Gaps = 56/323 (17%)
Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVR---NGGQILIADLR------GHE 57
TV HE + + LA+ S D + +I+++ NGG + LR GH+
Sbjct: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHD 231
Query: 58 GP----VWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAP 113
P V + W G +LA SYD IW E +H G + ++ W
Sbjct: 232 VPSNKDVTSLDWNSD--GTLLAMGSYDGFARIWTENGNLASTLGQHKG---PIFALKWNK 286
Query: 114 HDYGLILACGSSDGAISLLTYTGEGQ----------WEVKKINNAHTIGCNAVSWAPAVV 163
+L+ G I +TGE + +V NN C+
Sbjct: 287 KG-NYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCR 345
Query: 164 PGSLIDHP------SGQKPNYIKRFASG----GC--DNLIKLWKEEEDGQWKEEQKLEAH 211
G DHP + N IK SG C D +K+W ++D + L+AH
Sbjct: 346 LG--CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHD---LQAH 400
Query: 212 SDWVRDVAWA---PSIGLPTSTI--ASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVW 266
S + + W+ P+ P S+I AS S D V +W + L K + V+
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCT----HTLMKHQEPVY 456
Query: 267 HVSWSITANILAVSGGDNKVTLW 289
V++S LA D V +W
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIW 479
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 62.8 bits (151), Expect = 4e-10
Identities = 74/308 (24%), Positives = 114/308 (37%), Gaps = 83/308 (26%)
Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84
GT LA S D +I+ NG L + L H+GP++ + W GN + S D+ I
Sbjct: 247 GTLLAMGSYDGFARIW-TENGN--LASTLGQHKGPIFALKWNKK--GNYVLSAGVDKTTI 301
Query: 85 IWREENGT----------------WEKSHEHA-----------------------GHDSS 105
IW G W+ + A GH +
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361
Query: 106 VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNA-----VSWAP 160
VN++ W P G++LA S D + + W +K+ H + ++ + W+P
Sbjct: 362 VNAIKWDPS--GMLLASCSDDMTLKI--------WSMKQDACVHDLQAHSKEIYTIKWSP 411
Query: 161 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 220
P+ PN AS D+ ++LW E Q L H + V VA+
Sbjct: 412 T--------GPATSNPNSSIMLASASFDSTVRLWDVE---QGVCTHTLMKHQEPVYSVAF 460
Query: 221 APSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDV--VWHVSWSITANILA 278
+P +AS S D V IW NT S L+H + ++ V W+ + +
Sbjct: 461 SPD----GKYLASGSFDKYVHIW-------NTQSGSLVHSYQGTGGIFEVCWNARGDKVG 509
Query: 279 VSGGDNKV 286
S D V
Sbjct: 510 ASASDGSV 517
Score = 52.4 bits (124), Expect = 5e-07
Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 13/122 (10%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA----- 66
H + ++ + D G LA+CS D ++KI+ ++ + DL+ H ++ + W+
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA--CVHDLQAHSKEIYTIKWSPTGPA 415
Query: 67 --HPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGS 124
+P +LAS S+D V +W E G +H H V SV ++P G LA GS
Sbjct: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVC--THTLMKHQEPVYSVAFSPD--GKYLASGS 471
Query: 125 SD 126
D
Sbjct: 472 FD 473
Score = 51.2 bits (121), Expect = 1e-06
Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 9/105 (8%)
Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 87
LA+ S D +V+++DV G + L H+ PV+ VA++ G LAS S+D+ V IW
Sbjct: 425 LASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPD--GKYLASGSFDKYVHIWN 480
Query: 88 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132
++G+ S++ G + VCW + G + +SDG++ +L
Sbjct: 481 TQSGSLVHSYQGTG---GIFEVCW--NARGDKVGASASDGSVCVL 520
Score = 46.2 bits (108), Expect = 4e-05
Identities = 80/323 (24%), Positives = 121/323 (37%), Gaps = 56/323 (17%)
Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVR---NGGQILIADLR------GHE 57
TV HE + + LA+ S D + +I+++ NGG + LR GH+
Sbjct: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHD 231
Query: 58 GP----VWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAP 113
P V + W G +LA SYD IW E +H G + ++ W
Sbjct: 232 VPSNKDVTSLDWNSD--GTLLAMGSYDGFARIWTENGNLASTLGQHKG---PIFALKWNK 286
Query: 114 HDYGLILACGSSDGAISLLTYTGEGQ----------WEVKKINNAHTIGCNAVSWAPAVV 163
+L+ G I +TGE + +V NN C+
Sbjct: 287 KG-NYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCR 345
Query: 164 PGSLIDHP------SGQKPNYIKRFASG----GC--DNLIKLWKEEEDGQWKEEQKLEAH 211
G DHP + N IK SG C D +K+W ++D + L+AH
Sbjct: 346 LG--CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHD---LQAH 400
Query: 212 SDWVRDVAWA---PSIGLPTSTI--ASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVW 266
S + + W+ P+ P S+I AS S D V +W + L K + V+
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCT----HTLMKHQEPVY 456
Query: 267 HVSWSITANILAVSGGDNKVTLW 289
V++S LA D V +W
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIW 479
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 60.1 bits (144), Expect = 3e-09
Identities = 71/299 (23%), Positives = 115/299 (38%), Gaps = 48/299 (16%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQIL-IADLRGHEGPVWQVAWAHPMY 70
H D++ + G A+C+ D+SV+I+ + GQ++ +A GH V V + +
Sbjct: 375 HTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSR-LK 433
Query: 71 GNILASCSYDRKVIIW-----------REENG--TWEKSHEHAGHDSSVNSVCWAPHDYG 117
+ L + S D V +W +NG + HD +NSV AP+D
Sbjct: 434 ESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPND-- 491
Query: 118 LILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPN 177
+LA GS D L Q ++ + + H G V ++P
Sbjct: 492 KLLATGSQDRTAKLWALP---QCQLLGVFSGHRRGLWCVQFSP----------------- 531
Query: 178 YIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQD 237
+ A+ D IKLW ++ K E H V VA+ + + S D
Sbjct: 532 MDQVLATASADGTIKLWALQDFSCLK---TFEGHDASVLKVAFVSR----GTQLLSSGSD 584
Query: 238 GRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 296
G V +WT N + L D VW + S + D++V LWK+ + +
Sbjct: 585 GLVKLWTI----KNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAE 639
Score = 44.7 bits (104), Expect = 1e-04
Identities = 51/201 (25%), Positives = 83/201 (41%), Gaps = 30/201 (14%)
Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66
T H+ I+ + LAT S DR+ K++ + L+ GH +W V ++
Sbjct: 473 TTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQ--LLGVFSGHRRGLWCVQFS 530
Query: 67 HPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSD 126
PM +LA+ S D + +W ++ + K+ E GHD+SV V + G L SD
Sbjct: 531 -PM-DQVLATASADGTIKLWALQDFSCLKTFE--GHDASVLKVAFVSR--GTQLLSSGSD 584
Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVS-WAPAVVPGSLIDHPSGQKPNYIKRFASG 185
G + L W +K T+ + W + L DH +G
Sbjct: 585 GLVKL--------WTIKNNECVRTLDAHEDKVWG--LHCSRLDDHA-----------LTG 623
Query: 186 GCDNLIKLWKEEEDGQWKEEQ 206
D+ + LWK+ + + EEQ
Sbjct: 624 ASDSRVILWKDVTEAEQAEEQ 644
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 59.3 bits (142), Expect = 4e-09
Identities = 60/219 (27%), Positives = 100/219 (45%), Gaps = 41/219 (18%)
Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 87
L +CS D S++ +D+ + ++ +GH PVW + + Y AS S+DR +W
Sbjct: 357 LLSCSEDMSIRYWDLGSFTNTVL--YQGHAYPVWDLDISP--YSLYFASGSHDRTARLW- 411
Query: 88 EENGTWEKSHE---HAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 144
++++++ +AGH + V+ V + P+ LA GS+D + L W ++
Sbjct: 412 ----SFDRTYPLRIYAGHLADVDCVKFHPNSN--YLATGSTDKTVRL--------WSAQQ 457
Query: 145 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE 204
N+ + P + SL P+G K AS G D +KLW +KE
Sbjct: 458 GNSVRLFTGHR---GPVL---SLAFSPNG------KYLASAGEDQRLKLWDLASGTLYKE 505
Query: 205 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243
L H+D + + ++P GL IAS S D V +W
Sbjct: 506 ---LRGHTDNITSLTFSPDSGL----IASASMDNSVRVW 537
Score = 52.8 bits (125), Expect = 4e-07
Identities = 60/237 (25%), Positives = 101/237 (42%), Gaps = 37/237 (15%)
Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 112
LRGH GPV+ + G L SCS D + W + G++ + + GH V + +
Sbjct: 338 LRGHCGPVYSTRFLADSSG--LLSCSEDMSIRYW--DLGSFTNTVLYQGHAYPVWDLDIS 393
Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPS 172
P Y L A GS D L ++ + +I H + V + HP+
Sbjct: 394 P--YSLYFASGSHDRTARLWSFD---RTYPLRIYAGHLADVDCVKF-----------HPN 437
Query: 173 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232
NY+ A+G D ++LW + Q + H V +A++P+ +A
Sbjct: 438 S---NYL---ATGSTDKTVRLWSAQ---QGNSVRLFTGHRGPVLSLAFSPN----GKYLA 484
Query: 233 SCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289
S +D R+ +W D +S T K L D + +++S + ++A + DN V +W
Sbjct: 485 SAGEDQRLKLW---DLASGTLY-KELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
Length = 1336
Score = 56.6 bits (135), Expect = 3e-08
Identities = 53/205 (25%), Positives = 87/205 (42%), Gaps = 28/205 (13%)
Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70
+H++ + + +++ G L T S D K+FD+RN + L RGH+ VAW HP++
Sbjct: 286 AHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQV-FRGHKKEATAVAW-HPVH 343
Query: 71 GNILASCSYDRKVIIW----REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSD 126
+ AS D ++ W +E G E +HE + S+ W H G IL GS+D
Sbjct: 344 EGLFASGGSDGSLLFWHVGVEKEVGGMEMAHE-----GMIWSLAW--HPLGHILCSGSND 396
Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID--HPSGQKPNYIKRFAS 184
T G K+ + + + ++PG D +PN +
Sbjct: 397 HTSKFWTRNRPGD----KMRDRYNLN---------LLPGMSEDGVEYDDLEPNSLAVIPG 443
Query: 185 GGCDNLIKLWKEEEDGQWKEEQKLE 209
G +KL E+E E ++E
Sbjct: 444 MGIPEQLKLAMEQEQMGKDESNEIE 468
Score = 43.9 bits (102), Expect = 2e-04
Identities = 59/232 (25%), Positives = 81/232 (34%), Gaps = 65/232 (28%)
Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70
+H++ I +A + ATCS D +V+I+D + I LRGH V V W HP
Sbjct: 200 AHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERI--LRGHGADVKCVDW-HPTK 256
Query: 71 GNILASCSYDRKVI-IWREE----------------------NGTW-------------- 93
G +++ ++ I W + NG W
Sbjct: 257 GLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFD 316
Query: 94 -----EKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNA 148
E+ GH +V W P GL A G SDG SLL + + EV + A
Sbjct: 317 IRNLKEELQVFRGHKKEATAVAWHPVHEGL-FASGGSDG--SLLFWHVGVEKEVGGMEMA 373
Query: 149 HTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDG 200
H + W SL HP G SG D+ K W G
Sbjct: 374 H----EGMIW-------SLAWHPLGH------ILCSGSNDHTSKFWTRNRPG 408
Score = 34.7 bits (78), Expect = 0.12
Identities = 51/228 (22%), Positives = 85/228 (37%), Gaps = 38/228 (16%)
Query: 72 NILASCSYDRKVIIWREENGTWEKSHEHA---GHDSSVNSVCWAPHDYGLILACGSSDGA 128
N A+CS D V IW + + HE GH + V V W P GL+++ GS D
Sbjct: 215 NKFATCSDDGTVRIW-----DFLRCHEERILRGHGADVKCVDWHPTK-GLVVS-GSKDSQ 267
Query: 129 ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCD 188
+ W+ K + T+ + ++++ N++ + D
Sbjct: 268 QPIKF------WDPKTGQSLATLHAHK---------NTVMEVKLNLNGNWL---LTASRD 309
Query: 189 NLIKLWKEEEDGQWKEE-QKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247
+L KL+ + KEE Q H VAW P + AS DG + W
Sbjct: 310 HLCKLF---DIRNLKEELQVFRGHKKEATAVAWHP---VHEGLFASGGSDGSLLFWHVG- 362
Query: 248 ASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDG 295
++ H+ ++W ++W +IL D+ W + G
Sbjct: 363 VEKEVGGMEMAHE--GMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPG 408
>gi|14150171 THO complex 3 [Homo sapiens]
Length = 351
Score = 56.2 bits (134), Expect = 4e-08
Identities = 52/209 (24%), Positives = 91/209 (43%), Gaps = 27/209 (12%)
Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70
+H +H G RLA+ S D++ +F + + + RGH V Q+ W HP
Sbjct: 53 AHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCW-HPSN 111
Query: 71 GNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130
++ + S D+ + IW + G + ++CW+P G +A G+ D ++
Sbjct: 112 PDLFVTASGDKTIRIWDVRTTKCIATVNTKGENI---NICWSPD--GQTIAVGNKDDVVT 166
Query: 131 LL---TYTGEGQ----WEVKKI--NNAHTI-------GCNAVSWAPAVVPGSLID-HPSG 173
+ T+ + + +EV +I NN + + GC + P + P I+ HPS
Sbjct: 167 FIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSN 226
Query: 174 ----QKPNYIKRFASGGCDNLIKLWKEEE 198
+ K FA+G D L+ LW +E
Sbjct: 227 CICIKFDPMGKYFATGSADALVSLWDVDE 255
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 55.1 bits (131), Expect = 8e-08
Identities = 71/249 (28%), Positives = 101/249 (40%), Gaps = 36/249 (14%)
Query: 44 NGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHD 103
N L L GH V V ++ G LAS S DR +IIW +G +EK+ GH+
Sbjct: 28 NPNYALKCTLVGHTEAVSSVKFSPN--GEWLASSSADRLIIIWGAYDGKYEKT--LYGHN 83
Query: 104 SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVV 163
++ V W+ L+ A S D + L + K ++ + CN + P
Sbjct: 84 LEISDVAWSSDSSRLVSA--SDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN---FNP--- 135
Query: 164 PGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPS 223
P +LI SG D +K+W+ + K + L AHSD V V + S
Sbjct: 136 PSNLI--------------ISGSFDETVKIWEVKTG---KCLKTLSAHSDPVSAVHFNCS 178
Query: 224 IGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGD 283
S I S S DG IW DA+S L+ N V V +S + + D
Sbjct: 179 ----GSLIVSGSYDGLCRIW---DAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLD 231
Query: 284 NKVTLWKES 292
N + LW S
Sbjct: 232 NTLKLWDYS 240
Score = 47.8 bits (112), Expect = 1e-05
Identities = 68/262 (25%), Positives = 111/262 (42%), Gaps = 47/262 (17%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71
H I D +RL + S D+++K++DVR+G + L+GH V+ + P
Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGK--CLKTLKGHSNYVFCCNFNPP--S 137
Query: 72 NILASCSYDRKVIIWREENGTWEKS-HEHAGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130
N++ S S+D V IW + G K+ H+ S+V+ C G ++ GS DG +
Sbjct: 138 NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNC-----SGSLIVSGSYDG-LC 191
Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAP-------AVVPGSL----------IDHPSG 173
+ GQ +K + + + V ++P A + +L + +G
Sbjct: 192 RIWDAASGQC-LKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG 250
Query: 174 QKPNYIKRFA-----------SGGCDNLIKLWKEEEDGQWKE-EQKLEAHSDWVRDVAWA 221
K FA SG DNL+ +W + Q KE QKL+ H+D V A
Sbjct: 251 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW----NLQTKEIVQKLQGHTDVVISAACH 306
Query: 222 PSIGLPTSTIASCSQDGRVFIW 243
P+ L S A+ D + +W
Sbjct: 307 PTENLIAS--AALENDKTIKLW 326
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 53.5 bits (127), Expect = 2e-07
Identities = 57/227 (25%), Positives = 97/227 (42%), Gaps = 41/227 (18%)
Query: 71 GNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130
G LA+ S+D +++W + +++ + GH V SV ++PH G +LA S D +
Sbjct: 30 GKQLATASWDTFLMLWNFKPHA--RAYRYVGHKDVVTSVQFSPH--GNLLASASRDRTVR 85
Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNL 190
L G++ K AHT +V ++ GQ A+ D
Sbjct: 86 LWIPDKRGKFSEFK---AHTAPVRSVDFS-----------ADGQ------FLATASEDKS 125
Query: 191 IKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASS 250
IK+W + L H+ WVR ++P L I SCS+D + IW
Sbjct: 126 IKVWSMYRQ---RFLYSLYRHTHWVRCAKFSPDGRL----IVSCSEDKTIKIW------- 171
Query: 251 NTWSPKLLHKFNDVVW---HVSWSITANILAVSGGDNKVTLWKESVD 294
+T + + ++ F+D V V ++ + +A +G D V +W V+
Sbjct: 172 DTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN 218
Score = 53.5 bits (127), Expect = 2e-07
Identities = 69/284 (24%), Positives = 121/284 (42%), Gaps = 41/284 (14%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71
H+D++ Q +G LA+ S DR+V+++ G+ ++ + H PV V ++ G
Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGK--FSEFKAHTAPVRSVDFSAD--G 114
Query: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131
LA+ S D+ + +W + S H V ++P D LI++C S D I +
Sbjct: 115 QFLATASEDKSIKVWSMYRQRFLYSLYR--HTHWVRCAKFSP-DGRLIVSC-SEDKTIKI 170
Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID-HPSGQKPNYIKRFASGGCDNL 190
T + + +NN ++ +V + +D +PSG AS G D
Sbjct: 171 WDTTNK-----QCVNN----------FSDSVGFANFVDFNPSG------TCIASAGSDQT 209
Query: 191 IKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASS 250
+K+W + K Q + HS V +++ PS + + + S DG + I +
Sbjct: 210 VKVWDVRVN---KLLQHYQVHSGGVNCISFHPS----GNYLITASSDGTLKILDLLEGR- 261
Query: 251 NTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVD 294
L V+ VS+S + A G D +V LW+ + D
Sbjct: 262 ---LIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFD 302
Score = 35.8 bits (81), Expect = 0.053
Identities = 48/219 (21%), Positives = 79/219 (36%), Gaps = 46/219 (21%)
Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70
+H + G LAT S D+S+K++ + Q + L H W
Sbjct: 100 AHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR--QRFLYSLYRHTH--WVRCAKFSPD 155
Query: 71 GNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130
G ++ SCS D+ + IW N + + + N V + P G +A SD +
Sbjct: 156 GRLIVSCSEDKTIKIWDTTNK--QCVNNFSDSVGFANFVDFNPS--GTCIASAGSDQTVK 211
Query: 131 LLTYTGEGQWEVK-----KINNAHTIGCNAVSWAPA-----------------VVPGSLI 168
+ W+V+ + H+ G N +S+ P+ ++ G LI
Sbjct: 212 V--------WDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLI 263
Query: 169 DHPSGQKPNYI--------KRFASGGCDNLIKLWKEEED 199
G + FASGG D + LW+ D
Sbjct: 264 YTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFD 302
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 52.8 bits (125), Expect = 4e-07
Identities = 72/284 (25%), Positives = 110/284 (38%), Gaps = 36/284 (12%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQ-ILIADLRG-HEGPVWQVAWAHPM 69
HE + G LAT DRS+ +DVR +LI H V AW
Sbjct: 2060 HEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKD- 2118
Query: 70 YGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI 129
N+L SCS D V +W E+G ++ + GH S+V++V + S DG +
Sbjct: 2119 --NLLISCSSDGSVGLWDPESG--QRLGQFLGHQSAVSAVAAVEEH----VVSVSRDGTL 2170
Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDN 189
+ + G + + + A+ A PGS + + G D
Sbjct: 2171 KVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSEL------------LVVTVGLDG 2218
Query: 190 LIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249
+LW Q L HS VR A + + GL + + S+DG V +W +
Sbjct: 2219 ATRLWHPLLVCQ---THTLLGHSGPVRAAAVSETSGL----MLTASEDGSVRLWQVPKEA 2271
Query: 250 SNTWSPKLLHKFNDVVWHVSWSITANILAVSGGD-NKVTLWKES 292
+T P+ V W S +AVSG ++ LW+E+
Sbjct: 2272 DDTCIPRSSAAVTAVAWAPDGS-----MAVSGNQAGELILWQEA 2310
>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
Length = 446
Score = 52.8 bits (125), Expect = 4e-07
Identities = 32/115 (27%), Positives = 46/115 (40%), Gaps = 4/115 (3%)
Query: 176 PNYIKRFASGGCDNLIKLWKEEEDGQWKEEQK-LEAHSDWVRDVAWAPSIGLPTSTIASC 234
P R +G C I LW + G W +Q+ H+ V D+ W+P+ + ASC
Sbjct: 224 PRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQWSPT---ENTVFASC 280
Query: 235 SQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289
S D + IW A S + V +SWS L G D + +W
Sbjct: 281 SADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGDDGALKIW 335
Score = 42.0 bits (97), Expect = 7e-04
Identities = 42/205 (20%), Positives = 76/205 (37%), Gaps = 41/205 (20%)
Query: 50 IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWRE-ENGTWEKSHE-HAGHDSSVN 107
I GH G + + W+ + G +L + + +W + G+W GH SV
Sbjct: 207 IFSFAGHMGEGFALDWSPRVTGRLLTG-DCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVE 265
Query: 108 SVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINN---------AHTIGCNAVSW 158
+ W+P + + +C S+D +I + W+++ + AH N +SW
Sbjct: 266 DLQWSPTENTVFASC-SADASIRI--------WDIRAAPSKACMLTTATAHDGDVNVISW 316
Query: 159 APAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDV 218
S ++P + SGG D +K+W + + H V V
Sbjct: 317 -------------SRREPFLL----SGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSV 359
Query: 219 AWAPSIGLPTSTIASCSQDGRVFIW 243
W P + A+ D ++ W
Sbjct: 360 EWHPQ---DSGVFAASGADHQITQW 381
Score = 41.6 bits (96), Expect = 0.001
Identities = 42/174 (24%), Positives = 70/174 (40%), Gaps = 27/174 (15%)
Query: 27 RLATCSSDRSVKIFDVRNGGQILIADLR---GHEGPVWQVAWAHPMYGNILASCSYDRKV 83
RL T +++ ++ +GG + D R GH V + W+ P + ASCS D +
Sbjct: 229 RLLTGDCQKNIHLWTPTDGGSWHV-DQRPFVGHTRSVEDLQWS-PTENTVFASCSADASI 286
Query: 84 IIW--REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWE 141
IW R HD VN + W+ + L G DGA+ + W+
Sbjct: 287 RIWDIRAAPSKACMLTTATAHDGDVNVISWSRRE--PFLLSGGDDGALKI--------WD 336
Query: 142 VKKINNAHTIGCNAVSWAPAVVPGSLID-HPSGQKPNYIKRFASGGCDNLIKLW 194
+++ + G ++ V P + ++ HP FA+ G D+ I W
Sbjct: 337 LRQFKS----GSPVATFKQHVAPVTSVEWHPQDSGV-----FAASGADHQITQW 381
Score = 38.1 bits (87), Expect = 0.011
Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 9/104 (8%)
Query: 26 TRLATCSSDRSVKIFDVRNGGQ--ILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV 83
T A+CS+D S++I+D+R ++ H+G V ++W+ L S D +
Sbjct: 275 TVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSR--REPFLLSGGDDGAL 332
Query: 84 IIW---REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGS 124
IW + ++G+ + + H + V SV W P D G+ A G+
Sbjct: 333 KIWDLRQFKSGSPVATFKQ--HVAPVTSVEWHPQDSGVFAASGA 374
>gi|223029510 echinoderm microtubule associated protein like 4
isoform b [Homo sapiens]
Length = 923
Score = 52.8 bits (125), Expect = 4e-07
Identities = 56/247 (22%), Positives = 98/247 (39%), Gaps = 47/247 (19%)
Query: 52 DLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR--EENGTWEKSHEHAGHDSSVNSV 109
+++GH +W +A HP + ++L +C+ DR+V +W E W + + GH
Sbjct: 529 EVQGHTDELWGLA-THP-FKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGH------- 579
Query: 110 CWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID 169
C H G ++A G+ G +L E + + + HT G +S + G+ +
Sbjct: 580 CADFHPSGTVVAIGTHSGRWFVL------DAETRDLVSIHTDGNEQLSVMRYSIDGTFL- 632
Query: 170 HPSGQKPNYIKRFASGGCDNLIKLWKEEEDG-QWKEEQKLEAHSDWVRDVAWAPSIGLPT 228
A G DN I L+ E+G ++ + HS ++ + W+P
Sbjct: 633 -------------AVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPD----N 675
Query: 229 STIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTL 288
I S S D + W + KL+ +D + W+ +L G +
Sbjct: 676 KYIMSNSGDYEILYWDIPNGC------KLIRNRSDCK-DIDWTTYTCVL----GFQVFGV 724
Query: 289 WKESVDG 295
W E DG
Sbjct: 725 WPEGSDG 731
>gi|19923497 echinoderm microtubule associated protein like 4
isoform a [Homo sapiens]
Length = 981
Score = 52.8 bits (125), Expect = 4e-07
Identities = 56/247 (22%), Positives = 98/247 (39%), Gaps = 47/247 (19%)
Query: 52 DLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR--EENGTWEKSHEHAGHDSSVNSV 109
+++GH +W +A HP + ++L +C+ DR+V +W E W + + GH
Sbjct: 587 EVQGHTDELWGLA-THP-FKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGH------- 637
Query: 110 CWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID 169
C H G ++A G+ G +L E + + + HT G +S + G+ +
Sbjct: 638 CADFHPSGTVVAIGTHSGRWFVL------DAETRDLVSIHTDGNEQLSVMRYSIDGTFL- 690
Query: 170 HPSGQKPNYIKRFASGGCDNLIKLWKEEEDG-QWKEEQKLEAHSDWVRDVAWAPSIGLPT 228
A G DN I L+ E+G ++ + HS ++ + W+P
Sbjct: 691 -------------AVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPD----N 733
Query: 229 STIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTL 288
I S S D + W + KL+ +D + W+ +L G +
Sbjct: 734 KYIMSNSGDYEILYWDIPNGC------KLIRNRSDCK-DIDWTTYTCVL----GFQVFGV 782
Query: 289 WKESVDG 295
W E DG
Sbjct: 783 WPEGSDG 789
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 52.8 bits (125), Expect = 4e-07
Identities = 73/263 (27%), Positives = 102/263 (38%), Gaps = 52/263 (19%)
Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 103
LRGHE V+ AW +P+ ++LAS S D IW EN T + G D
Sbjct: 165 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDV 222
Query: 104 ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 160
V S+ W + G +LA GS DG + T G N A T+G +
Sbjct: 223 PSNKDVTSLDW--NSEGTLLATGSYDGFARIWTKDG---------NLASTLGQH------ 265
Query: 161 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 220
G + +K N+I S G D +W + G+ K Q+ HS DV W
Sbjct: 266 ---KGPIFALKWNKKGNFI---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 316
Query: 221 APSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVS 280
+ +T ASCS D + I C K + V + W T N+LA
Sbjct: 317 QSN-----NTFASCSTD--MCIHVCKLGQDR--PIKTFQGHTNEVNAIKWDPTGNLLASC 367
Query: 281 GGDNKVTLWKESVDGQWVCISDV 303
D + +W D C+ D+
Sbjct: 368 SDDMTLKIWSMKQDN---CVHDL 387
Score = 50.8 bits (120), Expect = 2e-06
Identities = 36/105 (34%), Positives = 56/105 (53%), Gaps = 9/105 (8%)
Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 87
LA+ S D +V+++DV G I I L H+ PV+ VA++ G LAS S+D+ V IW
Sbjct: 415 LASASFDSTVRLWDVDRG--ICIHTLTKHQEPVYSVAFSPD--GRYLASGSFDKCVHIWN 470
Query: 88 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132
+ G S+ G + VCW + G + +SDG++ +L
Sbjct: 471 TQTGALVHSYRGTG---GIFEVCW--NAAGDKVGASASDGSVCVL 510
Score = 43.9 bits (102), Expect = 2e-04
Identities = 45/178 (25%), Positives = 73/178 (41%), Gaps = 37/178 (20%)
Query: 29 ATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW-- 86
A+CS+D + + + G I +GH V + W GN+LASCS D + IW
Sbjct: 323 ASCSTDMCIHVCKL--GQDRPIKTFQGHTNEVNAIKWDPT--GNLLASCSDDMTLKIWSM 378
Query: 87 REENGTWEKSHEHAGHDSSVNSVCWAPHDYG-------LILACGSSDGAISLLTYTGEGQ 139
+++N H+ H+ + ++ W+P G L+LA S D + L
Sbjct: 379 KQDNCV----HDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRL-------- 426
Query: 140 WEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEE 197
W+V + HT+ P S+ P G + ASG D + +W +
Sbjct: 427 WDVDRGICIHTL---TKHQEPVY---SVAFSPDG------RYLASGSFDKCVHIWNTQ 472
Score = 43.1 bits (100), Expect = 3e-04
Identities = 69/291 (23%), Positives = 113/291 (38%), Gaps = 56/291 (19%)
Query: 29 ATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWRE 88
+T S + V +R GGQ D+ ++ V + W G +LA+ SYD IW +
Sbjct: 202 STSGSTQLVLRHCIREGGQ----DVPSNKD-VTSLDWNSE--GTLLATGSYDGFARIWTK 254
Query: 89 ENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNA 148
+ +H G + ++ W IL+ G I +TGE + +
Sbjct: 255 DGNLASTLGQHKG---PIFALKWNKKG-NFILSAGVDKTTIIWDAHTGEAKQQFP----F 306
Query: 149 HTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKL 208
H+ V W Q N ++ C ++ KL GQ + +
Sbjct: 307 HSAPALDVDW---------------QSNNTFASCSTDMCIHVCKL------GQDRPIKTF 345
Query: 209 EAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHV 268
+ H++ V + W P+ L +ASCS D + IW+ + L N ++ +
Sbjct: 346 QGHTNEVNAIKWDPTGNL----LASCSDDMTLKIWSMKQDN----CVHDLQAHNKEIYTI 397
Query: 269 SWSIT--------ANILAVSGG-DNKVTLWKESVDGQWVCISDVNKGQGSV 310
WS T AN++ S D+ V LW VD + +CI + K Q V
Sbjct: 398 KWSPTGPGTNNPNANLMLASASFDSTVRLW--DVD-RGICIHTLTKHQEPV 445
>gi|89026256 PREDICTED: similar to actin related protein 2/3 complex
subunit 1B [Homo sapiens]
Length = 370
Score = 52.4 bits (124), Expect = 5e-07
Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 4/119 (3%)
Query: 26 TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVII 85
T++A C ++ V I++ + +L+ H G V + WA N + +C DR +
Sbjct: 19 TQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPE--SNRIVTCGTDRNAYV 76
Query: 86 WREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 144
W + TW+ + + + V WAP++ A GS IS+ + E W V K
Sbjct: 77 WTLKGRTWKPTLVILRINRAARCVRWAPNENK--FAVGSGSRVISICYFEQENDWWVCK 133
Score = 50.1 bits (118), Expect = 3e-06
Identities = 28/106 (26%), Positives = 48/106 (45%), Gaps = 9/106 (8%)
Query: 196 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSP 255
E+ +W + +L+ H+ V + WAP ++ I +C D ++WT TW P
Sbjct: 34 EKSGAKWTKVHELKEHNGQVTGIDWAPE----SNRIVTCGTDRNAYVWT---LKGRTWKP 86
Query: 256 KL-LHKFNDVVWHVSWSITANILAVSGGDNKVTL-WKESVDGQWVC 299
L + + N V W+ N AV G +++ + E + WVC
Sbjct: 87 TLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVC 132
Score = 40.4 bits (93), Expect = 0.002
Identities = 32/131 (24%), Positives = 51/131 (38%), Gaps = 24/131 (18%)
Query: 74 LASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI--SL 131
+A C + +V I+ + W K HE H+ V + WAP + I+ CG+ A +L
Sbjct: 21 IAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAP-ESNRIVTCGTDRNAYVWTL 79
Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 191
T + + +IN A V WAP +FA G +I
Sbjct: 80 KGRTWKPTLVILRINRA----ARCVRWAPNE-----------------NKFAVGSGSRVI 118
Query: 192 KLWKEEEDGQW 202
+ E++ W
Sbjct: 119 SICYFEQENDW 129
>gi|5031601 actin related protein 2/3 complex subunit 1B [Homo
sapiens]
Length = 372
Score = 52.4 bits (124), Expect = 5e-07
Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 4/119 (3%)
Query: 26 TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVII 85
T++A C ++ V I++ + +L+ H G V + WA N + +C DR +
Sbjct: 21 TQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPE--SNRIVTCGTDRNAYV 78
Query: 86 WREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 144
W + TW+ + + + V WAP++ A GS IS+ + E W V K
Sbjct: 79 WTLKGRTWKPTLVILRINRAARCVRWAPNENK--FAVGSGSRVISICYFEQENDWWVCK 135
Score = 50.1 bits (118), Expect = 3e-06
Identities = 28/106 (26%), Positives = 48/106 (45%), Gaps = 9/106 (8%)
Query: 196 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSP 255
E+ +W + +L+ H+ V + WAP ++ I +C D ++WT TW P
Sbjct: 36 EKSGAKWTKVHELKEHNGQVTGIDWAPE----SNRIVTCGTDRNAYVWT---LKGRTWKP 88
Query: 256 KL-LHKFNDVVWHVSWSITANILAVSGGDNKVTL-WKESVDGQWVC 299
L + + N V W+ N AV G +++ + E + WVC
Sbjct: 89 TLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVC 134
Score = 40.4 bits (93), Expect = 0.002
Identities = 32/131 (24%), Positives = 51/131 (38%), Gaps = 24/131 (18%)
Query: 74 LASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI--SL 131
+A C + +V I+ + W K HE H+ V + WAP + I+ CG+ A +L
Sbjct: 23 IAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAP-ESNRIVTCGTDRNAYVWTL 81
Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 191
T + + +IN A V WAP +FA G +I
Sbjct: 82 KGRTWKPTLVILRINRA----ARCVRWAPNE-----------------NKFAVGSGSRVI 120
Query: 192 KLWKEEEDGQW 202
+ E++ W
Sbjct: 121 SICYFEQENDW 131
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 51.6 bits (122), Expect = 9e-07
Identities = 39/120 (32%), Positives = 55/120 (45%), Gaps = 8/120 (6%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71
H D + D G +LAT S D +VK++D+ G IL GH VW W G
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCIL--TFEGHSRAVWSCTW--HSCG 448
Query: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131
N +AS S D+ IW + + GH SVNS+ + P + L S+D +S+
Sbjct: 449 NFVASSSLDKTSKIWDVNSERCRCT--LYGHTDSVNSIEFFP--FSNTLLTSSADKTLSI 504
Score = 35.4 bits (80), Expect = 0.069
Identities = 33/118 (27%), Positives = 56/118 (47%), Gaps = 9/118 (7%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71
H I+DA D G +A+C + K++D R I+ D+ GP G
Sbjct: 519 HMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDI----GPSPGNEVNFDSSG 574
Query: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI 129
+LA S + + + ++G + H+ GH++ ++V ++ HD G IL G SDG +
Sbjct: 575 RVLAQASGNGVIHLLDLKSG---EIHKLMGHENEAHTVVFS-HD-GEILFSGGSDGTV 627
Score = 30.4 bits (67), Expect = 2.2
Identities = 38/144 (26%), Positives = 60/144 (41%), Gaps = 15/144 (10%)
Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71
H D ++ + + L T S+D+++ I+D R G I L GH + + G
Sbjct: 477 HTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG--ICEQSLYGHMHSINDAIF--DPRG 532
Query: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHD---SSVNSVCWAPHDYGLILACGSSDGA 128
+++ASC +W + K D S N V + G +LA S +G
Sbjct: 533 HMIASCDACGVTKLW-----DFRKLLPIVSIDIGPSPGNEVNF--DSSGRVLAQASGNGV 585
Query: 129 ISLLTY-TGEGQWEVKKINNAHTI 151
I LL +GE + N AHT+
Sbjct: 586 IHLLDLKSGEIHKLMGHENEAHTV 609
Score = 29.6 bits (65), Expect = 3.8
Identities = 21/80 (26%), Positives = 32/80 (40%), Gaps = 10/80 (12%)
Query: 211 HSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT-CDDASSNTWSPKLLHKFNDVVWHVS 269
H+DW+ D + PS +A+ S D V +W C T+ + VW +
Sbjct: 393 HTDWLSDCCFHPS----GDKLATSSGDTTVKLWDLCKGDCILTFEGH-----SRAVWSCT 443
Query: 270 WSITANILAVSGGDNKVTLW 289
W N +A S D +W
Sbjct: 444 WHSCGNFVASSSLDKTSKIW 463
>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
sapiens]
Length = 390
Score = 51.2 bits (121), Expect = 1e-06
Identities = 40/142 (28%), Positives = 67/142 (47%), Gaps = 22/142 (15%)
Query: 6 NTVDTSHEDMIHDAQMD------YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP 59
NT SH H A+++ Y LAT S+D++V ++D+RN ++ + H+
Sbjct: 226 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL-KLKLHSFESHKDE 284
Query: 60 VWQVAWAHPMYGNILASCSYDRKVIIWR------------EENGTWEKSHEHAGHDSSVN 107
++QV W+ P ILAS DR++ +W E+G E H GH + ++
Sbjct: 285 IFQVQWS-PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKIS 343
Query: 108 SVCWAPHDYGLILACGSSDGAI 129
W P++ +I C S+ I
Sbjct: 344 DFSWNPNEPWVI--CSVSEDNI 363
Score = 40.8 bits (94), Expect = 0.002
Identities = 53/214 (24%), Positives = 80/214 (37%), Gaps = 34/214 (15%)
Query: 101 GHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTG---EGQW-EVKKINNAHTIGCNAV 156
GH + W P+ G +L+ S D I L + EG+ + K I HT V
Sbjct: 140 GHQKEGYGLSWNPNLSGHLLSA-SDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 198
Query: 157 SWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVR 216
SW + H S F S D + +W + K ++AH+ V
Sbjct: 199 SWH--------LLHES--------LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVN 242
Query: 217 DVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFN---DVVWHVSWSI- 272
+++ P +A+ S D V +W + LH F D ++ V WS
Sbjct: 243 CLSFNP---YSEFILATGSADKTVALWDLRNLKLK------LHSFESHKDEIFQVQWSPH 293
Query: 273 TANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306
ILA SG D ++ +W S G+ D G
Sbjct: 294 NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 327
Score = 38.5 bits (88), Expect = 0.008
Identities = 42/167 (25%), Positives = 71/167 (42%), Gaps = 16/167 (9%)
Query: 7 TVDTSHEDMIHDAQMDYYGTRL-ATCSSDRSVKIFDVRNGGQILIA-DLRGHEGPVWQVA 64
T+ T H ++ D L + + D+ + I+D R+ + + H V ++
Sbjct: 186 TIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLS 245
Query: 65 WAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGS 124
+ +P ILA+ S D+ V +W N K H H + V W+PH+ ILA
Sbjct: 246 F-NPYSEFILATGSADKTVALWDLRNLKL-KLHSFESHKDEIFQVQWSPHN-ETILASSG 302
Query: 125 SDGAISL--LTYTGE---------GQWEVKKINNAHTIGCNAVSWAP 160
+D +++ L+ GE G E+ I+ HT + SW P
Sbjct: 303 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 349
Score = 36.2 bits (82), Expect = 0.040
Identities = 42/197 (21%), Positives = 75/197 (38%), Gaps = 30/197 (15%)
Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW-----REENGTWEKSHEHAGHDSSVN 107
LRGH+ + ++W + G++L S S D + +W +E + GH + V
Sbjct: 138 LRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 196
Query: 108 SVCW-APHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGS 166
V W H+ + + D + + + +AHT N +S+ P
Sbjct: 197 DVSWHLLHE--SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP------ 248
Query: 167 LIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL 226
+I A+G D + LW + + E+H D + V W+P
Sbjct: 249 --------YSEFI--LATGSADKTVALW--DLRNLKLKLHSFESHKDEIFQVQWSPH--- 293
Query: 227 PTSTIASCSQDGRVFIW 243
+ +AS D R+ +W
Sbjct: 294 NETILASSGTDRRLNVW 310
>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
sapiens]
Length = 424
Score = 51.2 bits (121), Expect = 1e-06
Identities = 40/142 (28%), Positives = 67/142 (47%), Gaps = 22/142 (15%)
Query: 6 NTVDTSHEDMIHDAQMD------YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP 59
NT SH H A+++ Y LAT S+D++V ++D+RN ++ + H+
Sbjct: 260 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL-KLKLHSFESHKDE 318
Query: 60 VWQVAWAHPMYGNILASCSYDRKVIIWR------------EENGTWEKSHEHAGHDSSVN 107
++QV W+ P ILAS DR++ +W E+G E H GH + ++
Sbjct: 319 IFQVQWS-PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKIS 377
Query: 108 SVCWAPHDYGLILACGSSDGAI 129
W P++ +I C S+ I
Sbjct: 378 DFSWNPNEPWVI--CSVSEDNI 397
Score = 40.8 bits (94), Expect = 0.002
Identities = 53/214 (24%), Positives = 80/214 (37%), Gaps = 34/214 (15%)
Query: 101 GHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTG---EGQW-EVKKINNAHTIGCNAV 156
GH + W P+ G +L+ S D I L + EG+ + K I HT V
Sbjct: 174 GHQKEGYGLSWNPNLSGHLLSA-SDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 232
Query: 157 SWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVR 216
SW + H S F S D + +W + K ++AH+ V
Sbjct: 233 SWH--------LLHES--------LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVN 276
Query: 217 DVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFN---DVVWHVSWSI- 272
+++ P +A+ S D V +W + LH F D ++ V WS
Sbjct: 277 CLSFNP---YSEFILATGSADKTVALWDLRNLKLK------LHSFESHKDEIFQVQWSPH 327
Query: 273 TANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306
ILA SG D ++ +W S G+ D G
Sbjct: 328 NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 361
Score = 38.5 bits (88), Expect = 0.008
Identities = 42/167 (25%), Positives = 71/167 (42%), Gaps = 16/167 (9%)
Query: 7 TVDTSHEDMIHDAQMDYYGTRL-ATCSSDRSVKIFDVRNGGQILIA-DLRGHEGPVWQVA 64
T+ T H ++ D L + + D+ + I+D R+ + + H V ++
Sbjct: 220 TIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLS 279
Query: 65 WAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGS 124
+ +P ILA+ S D+ V +W N K H H + V W+PH+ ILA
Sbjct: 280 F-NPYSEFILATGSADKTVALWDLRNLKL-KLHSFESHKDEIFQVQWSPHN-ETILASSG 336
Query: 125 SDGAISL--LTYTGE---------GQWEVKKINNAHTIGCNAVSWAP 160
+D +++ L+ GE G E+ I+ HT + SW P
Sbjct: 337 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 383
Score = 36.2 bits (82), Expect = 0.040
Identities = 42/197 (21%), Positives = 75/197 (38%), Gaps = 30/197 (15%)
Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW-----REENGTWEKSHEHAGHDSSVN 107
LRGH+ + ++W + G++L S S D + +W +E + GH + V
Sbjct: 172 LRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 230
Query: 108 SVCW-APHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGS 166
V W H+ + + D + + + +AHT N +S+ P
Sbjct: 231 DVSWHLLHE--SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP------ 282
Query: 167 LIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL 226
+I A+G D + LW + + E+H D + V W+P
Sbjct: 283 --------YSEFI--LATGSADKTVALW--DLRNLKLKLHSFESHKDEIFQVQWSPH--- 327
Query: 227 PTSTIASCSQDGRVFIW 243
+ +AS D R+ +W
Sbjct: 328 NETILASSGTDRRLNVW 344
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,172,733
Number of Sequences: 37866
Number of extensions: 658929
Number of successful extensions: 2646
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 177
Number of HSP's that attempted gapping in prelim test: 1831
Number of HSP's gapped (non-prelim): 649
length of query: 322
length of database: 18,247,518
effective HSP length: 102
effective length of query: 220
effective length of database: 14,385,186
effective search space: 3164740920
effective search space used: 3164740920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.