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Search of human proteins with 33598946
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
(1290 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 2636 0.0
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 2632 0.0
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 1233 0.0
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 244 5e-64
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 239 2e-62
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 239 2e-62
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 238 3e-62
gi|19115964 phospholipase C delta 3 [Homo sapiens] 230 8e-60
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 227 6e-59
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 224 4e-58
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 224 4e-58
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 218 4e-56
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 218 4e-56
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 193 8e-49
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 185 2e-46
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 185 2e-46
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 174 4e-43
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 174 4e-43
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 174 6e-43
gi|11386139 phospholipase C beta 3 [Homo sapiens] 166 2e-40
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 164 4e-40
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 164 4e-40
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 155 3e-37
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 86 2e-16
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 80 1e-14
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 80 1e-14
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 75 4e-13
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 72 4e-12
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 71 6e-12
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 71 6e-12
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 2636 bits (6833), Expect = 0.0
Identities = 1290/1290 (100%), Positives = 1290/1290 (100%)
Query: 1 MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI 60
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
Sbjct: 1 MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI 60
Query: 61 TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL 120
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
Sbjct: 61 TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL 120
Query: 121 SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM 180
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
Sbjct: 121 SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM 180
Query: 181 LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA 240
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
Sbjct: 181 LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA 240
Query: 241 GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT 300
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
Sbjct: 241 GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT 300
Query: 301 FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG 360
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
Sbjct: 301 FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG 360
Query: 361 CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA 420
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
Sbjct: 361 CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA 420
Query: 421 QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM 480
QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
Sbjct: 421 QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM 480
Query: 481 YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS 540
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
Sbjct: 481 YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS 540
Query: 541 STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW 600
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
Sbjct: 541 STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW 600
Query: 601 RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT 660
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
Sbjct: 601 RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT 660
Query: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE 720
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE 720
Query: 721 GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP 780
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
Sbjct: 721 GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP 780
Query: 781 GFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLW 840
GFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLW
Sbjct: 781 GFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLW 840
Query: 841 FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS 900
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
Sbjct: 841 FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS 900
Query: 901 MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC 960
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
Sbjct: 901 MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC 960
Query: 961 RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS 1020
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
Sbjct: 961 RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS 1020
Query: 1021 SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS 1080
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS
Sbjct: 1021 SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS 1080
Query: 1081 SLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW 1140
SLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
Sbjct: 1081 SLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW 1140
Query: 1141 PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL 1200
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
Sbjct: 1141 PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL 1200
Query: 1201 ELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDF 1260
ELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDF
Sbjct: 1201 ELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDF 1260
Query: 1261 RISQEHLADHFDSRERRAPRRTRVNGDNRL 1290
RISQEHLADHFDSRERRAPRRTRVNGDNRL
Sbjct: 1261 RISQEHLADHFDSRERRAPRRTRVNGDNRL 1290
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 2632 bits (6821), Expect = 0.0
Identities = 1290/1291 (99%), Positives = 1290/1291 (99%), Gaps = 1/1291 (0%)
Query: 1 MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI 60
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
Sbjct: 1 MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI 60
Query: 61 TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL 120
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
Sbjct: 61 TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL 120
Query: 121 SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM 180
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
Sbjct: 121 SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM 180
Query: 181 LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA 240
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
Sbjct: 181 LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA 240
Query: 241 GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT 300
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
Sbjct: 241 GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT 300
Query: 301 FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG 360
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
Sbjct: 301 FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG 360
Query: 361 CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA 420
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
Sbjct: 361 CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA 420
Query: 421 QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM 480
QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
Sbjct: 421 QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM 480
Query: 481 YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS 540
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
Sbjct: 481 YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS 540
Query: 541 STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW 600
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
Sbjct: 541 STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW 600
Query: 601 RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT 660
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
Sbjct: 601 RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT 660
Query: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE 720
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE 720
Query: 721 GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP 780
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
Sbjct: 721 GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP 780
Query: 781 GFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLW 840
GFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLW
Sbjct: 781 GFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLW 840
Query: 841 FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS 900
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
Sbjct: 841 FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS 900
Query: 901 MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC 960
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
Sbjct: 901 MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC 960
Query: 961 RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS 1020
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
Sbjct: 961 RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS 1020
Query: 1021 SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS 1080
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS
Sbjct: 1021 SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS 1080
Query: 1081 SLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW 1140
SLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
Sbjct: 1081 SLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW 1140
Query: 1141 PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL 1200
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
Sbjct: 1141 PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL 1200
Query: 1201 ELASLLIKIDIFPAK-ENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFED 1259
ELASLLIKIDIFPAK ENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFED
Sbjct: 1201 ELASLLIKIDIFPAKQENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFED 1260
Query: 1260 FRISQEHLADHFDSRERRAPRRTRVNGDNRL 1290
FRISQEHLADHFDSRERRAPRRTRVNGDNRL
Sbjct: 1261 FRISQEHLADHFDSRERRAPRRTRVNGDNRL 1291
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 1233 bits (3190), Expect = 0.0
Identities = 645/1278 (50%), Positives = 866/1278 (67%), Gaps = 39/1278 (3%)
Query: 18 SDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIRE 77
++ E + R+LE+GTVMT+F +KS PER+T QV +ETRQ+ WS+ ADKIEG +DI E
Sbjct: 11 AEYEKSQIKRALELGTVMTVFSFRKST-PERRTVQVIMETRQVAWSKTADKIEGFLDIME 69
Query: 78 IKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGL 137
IKEIRPGK S+DF+R + A R + CF ILYG +F L TLSL A S+++ W+ GL
Sbjct: 70 IKEIRPGKNSKDFERAK---AVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126
Query: 138 TWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRER 197
L ++ + A TP IE WLRKQ YSVD+ R + IS ++LK +L +N++V + +FL+++
Sbjct: 127 KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDK 186
Query: 198 LTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEAST---LRAGERPELCRVSLPEF 254
++ ++++ QF Y+ LM+ QK++ F + S+ L +RP+ V L +F
Sbjct: 187 FVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDF 246
Query: 255 QQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQL 314
Q+FL+ Q E WA D +V+E M F+ D +RE EP+ F+DEF+T+LFS+ENS+W+ +
Sbjct: 247 QRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKY 306
Query: 315 DAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDG 374
DAV MNNPLSHYWISSSHNTYLTGDQ SESS EAY RCLRMGCRCIELDCWDGPDG
Sbjct: 307 DAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDG 366
Query: 375 MPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLG 434
PVIYHG T TTKIKF DV+ IK+HAFV S +PVILSIE+HCS+ QQR+MA+ FK+V G
Sbjct: 367 KPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFG 426
Query: 435 DTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGI 494
D LLTKP E SAD LPSP+QL+ KI+IKHKKL +V +M E+ + G
Sbjct: 427 DLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRG---DVDVNM---EDKKDEHKQQGE 480
Query: 495 LYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGK 554
LY+ D ++ +W HY + +K+ +S++ +EE P+++ TELH EKWFH K
Sbjct: 481 LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTM---EEEVPQDI-PPTELHFGEKWFHKK 536
Query: 555 LGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQ 614
+ + R AE+LL EYC+ETG DG+FLVRESETF DYTLSFWR+G+VQHCRI S
Sbjct: 537 V----EKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTM 592
Query: 615 DAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLT 674
+ GT K++LTDNL F S+Y LI HY++ LRC EFE+RL++PVP N HESK WY+ SL+
Sbjct: 593 EGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLS 652
Query: 675 RAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSE-FDS 733
R +AE MLMR+PRDGAFL+RKR +SYAI+FRA GK+KHCR+ ++G+ +LG S F+S
Sbjct: 653 RGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFES 712
Query: 734 LVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYV---EANP-M 789
LV+L+SYYEKH LYRKM+LRYP+ E LE+ E D +LY+ YV E NP M
Sbjct: 713 LVELVSYYEKHSLYRKMRLRYPVTPELLERY-NMERDINSLYDVSR--MYVDPSEINPSM 769
Query: 790 PTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEM 849
P + VKAL+DYKA+R DEL+F + A+I NV K+ GGWW+GDYG + Q +FPSNYVE++
Sbjct: 770 P--QRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDI 827
Query: 850 VNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSL 909
E E++ +++N PLG L RG+LD+ + P+GKN + FVF + +
Sbjct: 828 STADFEELEKQIIEDN-PLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPV 886
Query: 910 DVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEK 969
+ A D EEL +W + IRE+ D + K E+ + IA+ELS+LVVYC+P + K
Sbjct: 887 EFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPT--SKTK 944
Query: 970 IGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMW 1029
E +R++ SF ETKA+ + + K L+YN+ L+R+YPKGQR+DSSNYDP +W
Sbjct: 945 DNLENPDFREIRSFVETKADSII-RQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLW 1003
Query: 1030 ICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCA 1089
+CGSQ+VALNFQT DK MQMN ALF GYVLQP +MR E +DP S R +
Sbjct: 1004 LCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKI-LMT 1062
Query: 1090 ISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW--PAKPFHF 1147
++++VLGARHLPK GR I CPFVE+E+ GAEYD+ K KT V DNGL+P+W + F
Sbjct: 1063 LTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTF 1122
Query: 1148 QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLI 1207
+I +P AFLRFVVYEEDMFSD NFLA AT+P+K +K+G+R+VPLKN YSED+ELASLL+
Sbjct: 1123 EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
Query: 1208 KIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHL 1267
++ P E+ + S LR R + + QLF + + ++F +++ L
Sbjct: 1183 FCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQL 1242
Query: 1268 ADHFDSRERRAPRRTRVN 1285
+ + +R R RV+
Sbjct: 1243 QLYQEKCNKRL-REKRVS 1259
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 244 bits (622), Expect = 5e-64
Identities = 160/445 (35%), Positives = 236/445 (53%), Gaps = 29/445 (6%)
Query: 60 ITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKT 119
I W + I I I+E+ G+ S F RY D +F P+ CF I +G ++
Sbjct: 78 IRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYP-DGSFDPNC--CFSIYHGSH--RES 132
Query: 120 LSLQATSEDEVNMWIKGLTWLM-----EDTLQAPTPLQIERWLRKQFYSVDRNREDRISA 174
L L +TS + W+ GL +LM ED+L A ++WL++ F D+N + +S
Sbjct: 133 LDLVSTSSEVARTWVTGLRYLMAGISDEDSL-ARRQRTRDQWLKQTFDEADKNGDGSLSI 191
Query: 175 KDLKNMLSQVNYRVPNMRFLRE-RLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFL 233
++ +L ++N +P R + R D + G + + +F Y+ M S ++ + L L
Sbjct: 192 GEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYK--MMSTRRDLYLLML 249
Query: 234 EASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYF 293
S + L SL F L + ++ V Q+ + F P + +
Sbjct: 250 TYSN----HKDHLDAASLQRF----LQVEQKMAGVTLESCQDIIEQFEPCPENK-SKGLL 300
Query: 294 FLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAY 353
+D F + S ++N + V D M PLSHY+I+SSHNTYL GDQ S+S ++ Y
Sbjct: 301 GIDGFTNYTRSPAGDIFNPEHHHVHQD-MTQPLSHYFITSSHNTYLVGDQLMSQSRVDMY 359
Query: 354 ARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSI 413
A L+ GCRC+E+DCWDGPDG P+++HG+TLT+KI F DV+ TI ++AF+ +EYPVILSI
Sbjct: 360 AWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSI 419
Query: 414 EDHCSIAQQRNMAQYFKKVLGDTL-LTKPVEISADGLPSPNQLKRKILIKHKKL----AE 468
E+HCS+ QQ+ MAQY +LGD L L+ A LPSP LK KIL+K KKL +E
Sbjct: 420 ENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISE 479
Query: 469 GSAYEEVPTSMMYSENDISNSIKNG 493
+ EV E D + NG
Sbjct: 480 DAEEGEVSDEDSADEIDDDCKLLNG 504
Score = 169 bits (428), Expect = 2e-41
Identities = 111/330 (33%), Positives = 172/330 (52%), Gaps = 27/330 (8%)
Query: 890 KNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRK-K 948
+N RL V S S L AA +E + Q + + G +++ K
Sbjct: 571 RNGRLVVGSFSRRKKKGSKLKKAASVEEG---------DEGQDSPGGQSRGATRQKKTMK 621
Query: 949 IALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQL 1008
++ LS+LV Y + V + I E A +SSF ETKA + + + K ++L++N+ QL
Sbjct: 622 LSRALSDLVKYTKSVATHD--IEMEAASSWQVSSFSETKAHQILQQ-KPAQYLRFNQQQL 678
Query: 1009 SRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPST 1068
SRIYP R+DSSNY+P P W G Q+VALN+Q+ + +Q+N+A F CGYVL+P
Sbjct: 679 SRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGC 738
Query: 1069 MRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPK------NGRG-IVCPFVEIEVAGAEY 1121
M F+P + L G + + ++ + LPK RG I+ PFVE+E+ G
Sbjct: 739 MCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPV 798
Query: 1122 DSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVK 1181
D ++++T V DNG NP W + F + PE A +RF+V++ D ++F+ Q T
Sbjct: 799 DCSREQTRVVDDNGFNPTW-EETLVFMVHMPEIALVRFLVWDHDPIG-RDFIGQRTLAFS 856
Query: 1182 GLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
+ GYR V Y E +E AS+ + + +
Sbjct: 857 SMMPGYRHV-----YLEGMEEASIFVHVAV 881
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 239 bits (609), Expect = 2e-62
Identities = 165/502 (32%), Positives = 259/502 (51%), Gaps = 46/502 (9%)
Query: 21 EVLHLCRS-LEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIK 79
E + C S ++ GT M K+ + + F + ++ W + I I I
Sbjct: 13 EKVERCMSVMQSGTQMIKL--KRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIY 70
Query: 80 EIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTW 139
++ G+ S F R E D S CF I +G +++L L ++ +E WI GL +
Sbjct: 71 KVTEGRQSEIFHRQAEGNF---DPSCCFTIYHGNH--MESLDLITSNPEEARTWITGLKY 125
Query: 140 LM-----EDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFL 194
LM ED+L A ++W+++ F D+N + ++ +++ ++ ++N +P R +
Sbjct: 126 LMAGISDEDSL-AKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR-RKV 183
Query: 195 RERL--TDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLP 252
R+ D ++ G +T+ +F Y+ M S ++ + L L S + +++
Sbjct: 184 RQMFQEADTDENQGTLTFEEFCVFYK--MMSLRRDLYLLLLSYSDKKD-------HLTVE 234
Query: 253 EFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIE-------EPYFFLDEFVTFLFSK 305
E QFL Q ++ + D +++ E + ++ F F+ S
Sbjct: 235 ELAQFLKVEQ---------KMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSP 285
Query: 306 ENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIE 365
++N V D M+ PL +Y+I+SSHNTYLTGDQ S+S ++ YAR L+ GCRC+E
Sbjct: 286 ACDIFNPLHHEVYQD-MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVE 344
Query: 366 LDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNM 425
+DCWDGPDG PV++HG+TLT+KI F DV+ TI +HAFV +E+PVILSIE+HCSI QQR +
Sbjct: 345 VDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKI 404
Query: 426 AQYFKKVLGDTLLTKPVEI-SADGLPSPNQLKRKILIKHKKLAE--GSAYEEVPTSMMYS 482
AQY K + GD L V+ LPSP LK KIL+K KKL G EE S S
Sbjct: 405 AQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDS 464
Query: 483 ENDISNSIKNGILYLEDPVNHE 504
++I + K + Y H+
Sbjct: 465 ADEIEDECKFKLHYSNGTTEHQ 486
Score = 172 bits (435), Expect = 2e-42
Identities = 108/280 (38%), Positives = 155/280 (55%), Gaps = 20/280 (7%)
Query: 941 KIMERRK--KIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGK 998
++ RRK K+ ELS+LVVY V + + ++ SF ET+A + V + K +
Sbjct: 587 RLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGTTGNVLSFSETRAHQVVQQ-KSE 642
Query: 999 KFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGR 1058
+F+ YN+ QL+RIYP R+DSSN++PLP W G QLVALN+Q+ + MQ+N+A F
Sbjct: 643 QFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANG 702
Query: 1059 HCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPK------NGRG-IVCPF 1111
+CGYVL+P M F+PF L + ++V+ + LPK RG I+ PF
Sbjct: 703 NCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPF 762
Query: 1112 VEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQN 1171
VE+E+ G D K +T V DNG NPVW + F + PE A +RF+V++ D ++
Sbjct: 763 VEVEIIGLPVDCCKDQTRVVDDNGFNPVW-EETLTFTVHMPEIALVRFLVWDHDPIG-RD 820
Query: 1172 FLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
F+ Q T L GYR V Y E L AS+ + I I
Sbjct: 821 FVGQRTVTFSSLVPGYRHV-----YLEGLTEASIFVHITI 855
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 239 bits (609), Expect = 2e-62
Identities = 165/502 (32%), Positives = 259/502 (51%), Gaps = 46/502 (9%)
Query: 21 EVLHLCRS-LEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIK 79
E + C S ++ GT M K+ + + F + ++ W + I I I
Sbjct: 13 EKVERCMSVMQSGTQMIKL--KRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIY 70
Query: 80 EIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTW 139
++ G+ S F R E D S CF I +G +++L L ++ +E WI GL +
Sbjct: 71 KVTEGRQSEIFHRQAEGNF---DPSCCFTIYHGNH--MESLDLITSNPEEARTWITGLKY 125
Query: 140 LM-----EDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFL 194
LM ED+L A ++W+++ F D+N + ++ +++ ++ ++N +P R +
Sbjct: 126 LMAGISDEDSL-AKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR-RKV 183
Query: 195 RERL--TDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLP 252
R+ D ++ G +T+ +F Y+ M S ++ + L L S + +++
Sbjct: 184 RQMFQEADTDENQGTLTFEEFCVFYK--MMSLRRDLYLLLLSYSDKKD-------HLTVE 234
Query: 253 EFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIE-------EPYFFLDEFVTFLFSK 305
E QFL Q ++ + D +++ E + ++ F F+ S
Sbjct: 235 ELAQFLKVEQ---------KMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSP 285
Query: 306 ENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIE 365
++N V D M+ PL +Y+I+SSHNTYLTGDQ S+S ++ YAR L+ GCRC+E
Sbjct: 286 ACDIFNPLHHEVYQD-MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVE 344
Query: 366 LDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNM 425
+DCWDGPDG PV++HG+TLT+KI F DV+ TI +HAFV +E+PVILSIE+HCSI QQR +
Sbjct: 345 VDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKI 404
Query: 426 AQYFKKVLGDTLLTKPVEI-SADGLPSPNQLKRKILIKHKKLAE--GSAYEEVPTSMMYS 482
AQY K + GD L V+ LPSP LK KIL+K KKL G EE S S
Sbjct: 405 AQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDS 464
Query: 483 ENDISNSIKNGILYLEDPVNHE 504
++I + K + Y H+
Sbjct: 465 ADEIEDECKFKLHYSNGTTEHQ 486
Score = 172 bits (435), Expect = 2e-42
Identities = 108/280 (38%), Positives = 155/280 (55%), Gaps = 20/280 (7%)
Query: 941 KIMERRK--KIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGK 998
++ RRK K+ ELS+LVVY V + + ++ SF ET+A + V + K +
Sbjct: 587 RLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGTTGNVLSFSETRAHQVVQQ-KSE 642
Query: 999 KFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGR 1058
+F+ YN+ QL+RIYP R+DSSN++PLP W G QLVALN+Q+ + MQ+N+A F
Sbjct: 643 QFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANG 702
Query: 1059 HCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPK------NGRG-IVCPF 1111
+CGYVL+P M F+PF L + ++V+ + LPK RG I+ PF
Sbjct: 703 NCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPF 762
Query: 1112 VEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQN 1171
VE+E+ G D K +T V DNG NPVW + F + PE A +RF+V++ D ++
Sbjct: 763 VEVEIIGLPVDCCKDQTRVVDDNGFNPVW-EETLTFTVHMPEIALVRFLVWDHDPIG-RD 820
Query: 1172 FLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
F+ Q T L GYR V Y E L AS+ + I I
Sbjct: 821 FVGQRTVTFSSLVPGYRHV-----YLEGLTEASIFVHITI 855
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 238 bits (607), Expect = 3e-62
Identities = 158/473 (33%), Positives = 247/473 (52%), Gaps = 43/473 (9%)
Query: 49 KTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFV 108
+ F + ++ W + I I I ++ G+ S F R E D S CF
Sbjct: 22 RLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNF---DPSCCFT 78
Query: 109 ILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLM-----EDTLQAPTPLQIERWLRKQFYS 163
I +G +++L L ++ +E WI GL +LM ED+L A ++W+++ F
Sbjct: 79 IYHGNH--MESLDLITSNPEEARTWITGLKYLMAGISDEDSL-AKRQRTHDQWVKQTFEE 135
Query: 164 VDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERL--TDLEQRSGDITYGQFAQLYRSLM 221
D+N + ++ +++ ++ ++N +P R +R+ D ++ G +T+ +F Y+ M
Sbjct: 136 ADKNGDGLLNIEEIHQLMHKLNVNLPR-RKVRQMFQEADTDENQGTLTFEEFCVFYK--M 192
Query: 222 YSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFL 281
S ++ + L L S + +++ E QFL Q ++ +
Sbjct: 193 MSLRRDLYLLLLSYSDKKD-------HLTVEELAQFLKVEQ---------KMNNVTTDYC 236
Query: 282 RDPLREIE-------EPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSS 334
D +++ E + ++ F F+ S ++N V D M+ PL +Y+I+SS
Sbjct: 237 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD-MDQPLCNYYIASS 295
Query: 335 HNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVL 394
HNTYLTGDQ S+S ++ YAR L+ GCRC+E+DCWDGPDG PV++HG+TLT+KI F DV+
Sbjct: 296 HNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVV 355
Query: 395 HTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEI-SADGLPSPN 453
TI +HAFV +E+PVILSIE+HCSI QQR +AQY K + GD L V+ LPSP
Sbjct: 356 ETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQ 415
Query: 454 QLKRKILIKHKKLAE--GSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHE 504
LK KIL+K KKL G EE S S ++I + K + Y H+
Sbjct: 416 SLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQ 468
Score = 172 bits (435), Expect = 2e-42
Identities = 108/280 (38%), Positives = 155/280 (55%), Gaps = 20/280 (7%)
Query: 941 KIMERRK--KIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGK 998
++ RRK K+ ELS+LVVY V + + ++ SF ET+A + V + K +
Sbjct: 569 RLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGTTGNVLSFSETRAHQVVQQ-KSE 624
Query: 999 KFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGR 1058
+F+ YN+ QL+RIYP R+DSSN++PLP W G QLVALN+Q+ + MQ+N+A F
Sbjct: 625 QFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANG 684
Query: 1059 HCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPK------NGRG-IVCPF 1111
+CGYVL+P M F+PF L + ++V+ + LPK RG I+ PF
Sbjct: 685 NCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPF 744
Query: 1112 VEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQN 1171
VE+E+ G D K +T V DNG NPVW + F + PE A +RF+V++ D ++
Sbjct: 745 VEVEIIGLPVDCCKDQTRVVDDNGFNPVW-EETLTFTVHMPEIALVRFLVWDHDPIG-RD 802
Query: 1172 FLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
F+ Q T L GYR V Y E L AS+ + I I
Sbjct: 803 FVGQRTVTFSSLVPGYRHV-----YLEGLTEASIFVHITI 837
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 230 bits (586), Expect = 8e-60
Identities = 145/404 (35%), Positives = 213/404 (52%), Gaps = 42/404 (10%)
Query: 75 IREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWI 134
++ I+ +R G S R+ AF P + C I + + R K L L A + +E W+
Sbjct: 111 VQHIEAVREGHQSEGLRRF--GGAFAP--ARCLTIAF--KGRRKNLDLAAPTAEEAQRWV 164
Query: 135 KGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFL 194
+GLT L +++ W+ + D N++ ++S K++K++L VN + +M
Sbjct: 165 RGLTKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDM--- 221
Query: 195 RERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRV----- 249
Y L++ +S ++ +E R +RPEL +
Sbjct: 222 ---------------YAYL--LFKECDHSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYS 264
Query: 250 ------SLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLF 303
S PE +FL D QGE A Q L + ++ E LD F+ +L
Sbjct: 265 GEDRVLSAPELLEFLED-QGEEGATLARAQQLIQTYELNETAKQHE--LMTLDGFMMYLL 321
Query: 304 SKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRC 363
S E + ++ V D MN PL+HY+ISSSHNTYLT Q SS EAY R GCRC
Sbjct: 322 SPEGAALDNTHTCVFQD-MNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRC 380
Query: 364 IELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQR 423
+ELDCW+GP G PVIYHGHTLT+KI F DV+ +++HAF S YPVILS+E+HC + QQ
Sbjct: 381 VELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQA 440
Query: 424 NMAQYFKKVLGDTLLTKPVEI-SADGLPSPNQLKRKILIKHKKL 466
MA++ +LGD L+T+ ++ + + LPSP QLK ++L+K KKL
Sbjct: 441 AMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKL 484
Score = 193 bits (490), Expect = 1e-48
Identities = 129/351 (36%), Positives = 179/351 (50%), Gaps = 21/351 (5%)
Query: 868 LGDLL-RGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKI 926
LGD+L LD P + PE R+ V + + +D +EE +D ++
Sbjct: 450 LGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEE 509
Query: 927 REVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPET 986
EV A RL K+I+ ELS L VYC +SS E
Sbjct: 510 EEVEAAAQRRLA--------KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSER 561
Query: 987 KAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKP 1046
KA+K + +A G F+++N QL+R+YP G R++S+NY P MW G QLVALNFQTP
Sbjct: 562 KAKKLIREA-GNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYE 620
Query: 1047 MQMNQALFMTGRHCGYVLQPSTMR--DEAFDPFDKSSLRGLEPCAISIEVLGARHLPK-- 1102
M +N F+ CGYVL+P+ +R D FDP G +SI+VL A+ LPK
Sbjct: 621 MDLNAGRFLVNGQCGYVLKPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLN 676
Query: 1103 --NGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFV 1160
IV P V IE+ G D +Q+T++V++NG NP W + FQ+ PE A +RFV
Sbjct: 677 AEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRW-GQTLQFQLRAPELALVRFV 735
Query: 1161 VYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
V + D S +F+ Q T P+ LK GYR + L + L A+L I+I I
Sbjct: 736 VEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRI 786
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 227 bits (578), Expect = 6e-59
Identities = 147/437 (33%), Positives = 237/437 (54%), Gaps = 41/437 (9%)
Query: 63 SRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSL 122
+RG+ K + I +++ IR G S E+ P + ++ +G R L L
Sbjct: 53 ARGSAK--PSFSISDVETIRNGHDSELLRSLAEE---LPLEQGFTIVFHG---RRSNLDL 104
Query: 123 QATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLS 182
A S +E +W++GL L++ ++++WL F D+N++ ++S ++++ +L
Sbjct: 105 MANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLH 164
Query: 183 QVNYRVPN-MRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAG 241
+N + F + D Q SG + +F Q Y++L K ++ L S G
Sbjct: 165 LMNVEMDQEYAFSLFQAADTSQ-SGTLEGEEFVQFYKALT----KRAEVQELFESFSADG 219
Query: 242 ERPELCRVSLPEFQQFLLDYQGE--------LWAVDRLQVQEFMLSFLRDPLREIEEPYF 293
++ ++L EF FL + Q E L +DR + + LR +
Sbjct: 220 QK-----LTLLEFLDFLQEEQKERDCTSELALELIDRYEPSD------SGKLRHV----L 264
Query: 294 FLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAY 353
+D F+++L SK+ ++N + D M PL+HY+I SSHNTYL GDQ +SS+E Y
Sbjct: 265 SMDGFLSYLCSKDGDIFNPACLPIYQD-MTQPLNHYFICSSHNTYLVGDQLCGQSSVEGY 323
Query: 354 ARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSI 413
R L+ GCRC+E+D WDGP G PV+YHGHTLT++I F DV+ T+ ++AF S+YPVILS+
Sbjct: 324 IRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSL 383
Query: 414 EDHCSIAQQRNMAQYFKKVLGDTLLTKPVE-ISADGLPSPNQLKRKILIKHKKLA--EGS 470
E HCS QQ+ MA++ ++LG+ LL+ ++ + LPSP +L+RKIL+K KKL E
Sbjct: 384 ETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKILVKGKKLTLEEDL 443
Query: 471 AYEEVPTSMMYSENDIS 487
YEE E++++
Sbjct: 444 EYEEEEAEPELEESELA 460
Score = 165 bits (417), Expect = 3e-40
Identities = 95/263 (36%), Positives = 144/263 (54%), Gaps = 6/263 (2%)
Query: 953 LSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIY 1012
LS LV+Y + V F E + ++SSF ETKA++ + +A G +F+Q+N QLSR+Y
Sbjct: 493 LSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEA-GNEFVQHNTWQLSRVY 551
Query: 1013 PKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDE 1072
P G R DSSNY+P +W G Q+VA+N QT M + F CGYVL+P +RD
Sbjct: 552 PSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDI 611
Query: 1073 AFDPFDKSSLRGLEPCAISIEVLGARHLPKNGR----GIVCPFVEIEVAGAEYDSTKQKT 1128
+ + + + I+V+ + LPK + IV P V++++ G D+ +Q+T
Sbjct: 612 QSSFHPEKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQET 671
Query: 1129 EFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYR 1188
+V +NG NP W + F++ PE A LRFVV + D S +F+ Q T P ++ GYR
Sbjct: 672 NYVENNGFNPYW-GQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYR 730
Query: 1189 AVPLKNNYSEDLELASLLIKIDI 1211
+ L + L AS+ + I I
Sbjct: 731 HIHLLSKDGISLRPASIFVYICI 753
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 224 bits (571), Expect = 4e-58
Identities = 137/395 (34%), Positives = 220/395 (55%), Gaps = 24/395 (6%)
Query: 75 IREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWI 134
I +I+E+R G + +++ D + CF I++ + + TL L A S + W+
Sbjct: 69 IEDIQEVRMGHRTEGLEKFARDVP----EDRCFSIVF--KDQRNTLDLIAPSPADAQHWV 122
Query: 135 KGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFL 194
GL ++ + +++ W+ D+N+++++S K+L+N L ++N +V + +
Sbjct: 123 LGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDS-YA 181
Query: 195 RERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEF 254
R+ + + D + + + ++ + + +D F EA+ +GE +S+ +
Sbjct: 182 RKIFRECDHSQTDSLEDEEIEAFYKML-TQRVEIDRTFAEAAG--SGET-----LSVDQL 233
Query: 255 QQFLLDYQGELWAVDRLQ---VQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWN 311
FL Q E A L ++ + S R++ + D F+ +L S + S ++
Sbjct: 234 VTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTK-----DGFLMYLLSADGSAFS 288
Query: 312 SQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDG 371
V D M PLSHY +SSSHNTYL DQ + SS EAY R L GCRC+ELDCWDG
Sbjct: 289 LAHRRVYQD-MGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDG 347
Query: 372 PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKK 431
P+ P+IYHG+T T+KI F DVL I+++AF AS YPVILS+E+HC++ QQR MA++
Sbjct: 348 PNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHA 407
Query: 432 VLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKL 466
+LG LL +P++ + LPSP QLK KIL+K KKL
Sbjct: 408 ILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKL 442
Score = 176 bits (446), Expect = 1e-43
Identities = 105/290 (36%), Positives = 159/290 (54%), Gaps = 8/290 (2%)
Query: 928 EVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDE-EKIGTERACYRDMSSFPET 986
E+ A + K E + ++A ELS++V+YC+ V F GT + +M+SF E
Sbjct: 467 EMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSEN 526
Query: 987 KAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKP 1046
+A + + ++ G F+++N LSRIYP G R DSSNY P+ MW G Q+VALNFQTP
Sbjct: 527 RALRLLQES-GNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPE 585
Query: 1047 MQMNQALFMTGRHCGYVLQPSTMRDE--AFDPFDKSSLRGLEPCAISIEVLGARHLP--- 1101
M + Q F CGYVL+P+ +RD F+P + ++I V+ + LP
Sbjct: 586 MDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVN 645
Query: 1102 KNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVV 1161
KN IV P V +E+ G D ++T + +NG NP W + F F++ P+ A +RF+V
Sbjct: 646 KNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTE-FAFEVVVPDLALIRFLV 704
Query: 1162 YEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
+ D S +F+ Q+T P+ LK GYR V L + + A+L +KI +
Sbjct: 705 EDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISL 754
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 224 bits (571), Expect = 4e-58
Identities = 137/395 (34%), Positives = 220/395 (55%), Gaps = 24/395 (6%)
Query: 75 IREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWI 134
I +I+E+R G + +++ D + CF I++ + + TL L A S + W+
Sbjct: 90 IEDIQEVRMGHRTEGLEKFARDVP----EDRCFSIVF--KDQRNTLDLIAPSPADAQHWV 143
Query: 135 KGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFL 194
GL ++ + +++ W+ D+N+++++S K+L+N L ++N +V + +
Sbjct: 144 LGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDS-YA 202
Query: 195 RERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEF 254
R+ + + D + + + ++ + + +D F EA+ +GE +S+ +
Sbjct: 203 RKIFRECDHSQTDSLEDEEIEAFYKML-TQRVEIDRTFAEAAG--SGET-----LSVDQL 254
Query: 255 QQFLLDYQGELWAVDRLQ---VQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWN 311
FL Q E A L ++ + S R++ + D F+ +L S + S ++
Sbjct: 255 VTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTK-----DGFLMYLLSADGSAFS 309
Query: 312 SQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDG 371
V D M PLSHY +SSSHNTYL DQ + SS EAY R L GCRC+ELDCWDG
Sbjct: 310 LAHRRVYQD-MGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDG 368
Query: 372 PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKK 431
P+ P+IYHG+T T+KI F DVL I+++AF AS YPVILS+E+HC++ QQR MA++
Sbjct: 369 PNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHA 428
Query: 432 VLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKL 466
+LG LL +P++ + LPSP QLK KIL+K KKL
Sbjct: 429 ILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKL 463
Score = 176 bits (446), Expect = 1e-43
Identities = 105/290 (36%), Positives = 159/290 (54%), Gaps = 8/290 (2%)
Query: 928 EVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDE-EKIGTERACYRDMSSFPET 986
E+ A + K E + ++A ELS++V+YC+ V F GT + +M+SF E
Sbjct: 488 EMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSEN 547
Query: 987 KAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKP 1046
+A + + ++ G F+++N LSRIYP G R DSSNY P+ MW G Q+VALNFQTP
Sbjct: 548 RALRLLQES-GNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPE 606
Query: 1047 MQMNQALFMTGRHCGYVLQPSTMRDE--AFDPFDKSSLRGLEPCAISIEVLGARHLP--- 1101
M + Q F CGYVL+P+ +RD F+P + ++I V+ + LP
Sbjct: 607 MDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVN 666
Query: 1102 KNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVV 1161
KN IV P V +E+ G D ++T + +NG NP W + F F++ P+ A +RF+V
Sbjct: 667 KNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTE-FAFEVVVPDLALIRFLV 725
Query: 1162 YEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
+ D S +F+ Q+T P+ LK GYR V L + + A+L +KI +
Sbjct: 726 EDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISL 775
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 218 bits (554), Expect = 4e-56
Identities = 143/444 (32%), Positives = 225/444 (50%), Gaps = 40/444 (9%)
Query: 41 KKSQRPERKTFQVKLETRQITWSRGADKIEGA-IDIREIKEIRPGKTSRDF------DRY 93
+ + R + F + + + + W E A IDI+ IKE+R GK + F D+
Sbjct: 153 RSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQI 212
Query: 94 QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLME------DTLQA 147
ED AF ++YG + ++L L A S D N+W+ GL +L+ D L++
Sbjct: 213 SEDCAFS--------VIYGENY--ESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 262
Query: 148 PTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRF---LRERLTDLEQR 204
W+ + F +D + I+ + + +N + + +E ++
Sbjct: 263 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 322
Query: 205 SGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGE 264
++T +F +++ L P + ++ E + + FL QG
Sbjct: 323 GTEVTKEEFIEVFHELCTR-------PEIYFLLVQFSSNKEF--LDTKDLMMFLEAEQGV 373
Query: 265 LWAVDRLQVQEFMLSFLRDPLREIEEP-YFFLDEFVTFLFSKENSVWNSQLDAVCPDTMN 323
+ + ++ + +P +E +E + +D F +L S + +++ + VC D M
Sbjct: 374 AHINEEISLE---IIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQD-MK 429
Query: 324 NPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHT 383
PLSHY+I+SSHNTYL DQF S + Y R L+MGCR +ELD WDGPD PVIY GHT
Sbjct: 430 QPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHT 489
Query: 384 LTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVE 443
+T++I F V+ I ++AF ASEYP+IL +E+HCSI QQ+ M Q+ KK+LGD L T
Sbjct: 490 MTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPN 549
Query: 444 ISADGLPSPNQLKRKILIKHKKLA 467
+ LPSP+ LK KILIK KKL+
Sbjct: 550 VEESYLPSPDVLKGKILIKAKKLS 573
Score = 188 bits (477), Expect = 3e-47
Identities = 115/301 (38%), Positives = 170/301 (56%), Gaps = 15/301 (4%)
Query: 945 RRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYN 1004
+R ++ ELSELV C+ V F E ++ + Y ++ SF E A KY N+ G F+ YN
Sbjct: 610 KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGD-FVNYN 668
Query: 1005 RLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVL 1064
+ L+R++P R+DSSN +P W CG Q+VA+NFQTP M +N F +CGYVL
Sbjct: 669 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 728
Query: 1065 QPSTMRDEA--FDPFDKSSLRGLEPCAISIEVLGARHLPK-NGRG----IVCPFVEIEVA 1117
+P+ MR+E F K S+ G+ P + I+++ ++ PK G G +V P+V +E+
Sbjct: 729 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 788
Query: 1118 GAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQAT 1177
G D +Q+T+ V NG P++ + F FQI+ PE A +RFVV ++D D+ F+ Q T
Sbjct: 789 GIPADCAEQRTKTVHQNGDAPIFD-ESFEFQINLPELAMVRFVVLDDDYIGDE-FIGQYT 846
Query: 1178 FPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENG-----DLSPFSGTSLRERG 1232
P + L+TGYR VPL++ E L ASL + + I + G LS G RE
Sbjct: 847 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 906
Query: 1233 S 1233
S
Sbjct: 907 S 907
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 218 bits (554), Expect = 4e-56
Identities = 143/444 (32%), Positives = 225/444 (50%), Gaps = 40/444 (9%)
Query: 41 KKSQRPERKTFQVKLETRQITWSRGADKIEGA-IDIREIKEIRPGKTSRDF------DRY 93
+ + R + F + + + + W E A IDI+ IKE+R GK + F D+
Sbjct: 27 RSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQI 86
Query: 94 QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLME------DTLQA 147
ED AF ++YG + ++L L A S D N+W+ GL +L+ D L++
Sbjct: 87 SEDCAFS--------VIYGENY--ESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 136
Query: 148 PTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRF---LRERLTDLEQR 204
W+ + F +D + I+ + + +N + + +E ++
Sbjct: 137 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 196
Query: 205 SGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGE 264
++T +F +++ L P + ++ E + + FL QG
Sbjct: 197 GTEVTKEEFIEVFHELCTR-------PEIYFLLVQFSSNKEF--LDTKDLMMFLEAEQGV 247
Query: 265 LWAVDRLQVQEFMLSFLRDPLREIEEP-YFFLDEFVTFLFSKENSVWNSQLDAVCPDTMN 323
+ + ++ + +P +E +E + +D F +L S + +++ + VC D M
Sbjct: 248 AHINEEISLE---IIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQD-MK 303
Query: 324 NPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHT 383
PLSHY+I+SSHNTYL DQF S + Y R L+MGCR +ELD WDGPD PVIY GHT
Sbjct: 304 QPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHT 363
Query: 384 LTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVE 443
+T++I F V+ I ++AF ASEYP+IL +E+HCSI QQ+ M Q+ KK+LGD L T
Sbjct: 364 MTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPN 423
Query: 444 ISADGLPSPNQLKRKILIKHKKLA 467
+ LPSP+ LK KILIK KKL+
Sbjct: 424 VEESYLPSPDVLKGKILIKAKKLS 447
Score = 188 bits (477), Expect = 3e-47
Identities = 115/301 (38%), Positives = 170/301 (56%), Gaps = 15/301 (4%)
Query: 945 RRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYN 1004
+R ++ ELSELV C+ V F E ++ + Y ++ SF E A KY N+ G F+ YN
Sbjct: 484 KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGD-FVNYN 542
Query: 1005 RLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVL 1064
+ L+R++P R+DSSN +P W CG Q+VA+NFQTP M +N F +CGYVL
Sbjct: 543 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 602
Query: 1065 QPSTMRDEA--FDPFDKSSLRGLEPCAISIEVLGARHLPK-NGRG----IVCPFVEIEVA 1117
+P+ MR+E F K S+ G+ P + I+++ ++ PK G G +V P+V +E+
Sbjct: 603 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 662
Query: 1118 GAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQAT 1177
G D +Q+T+ V NG P++ + F FQI+ PE A +RFVV ++D D+ F+ Q T
Sbjct: 663 GIPADCAEQRTKTVHQNGDAPIFD-ESFEFQINLPELAMVRFVVLDDDYIGDE-FIGQYT 720
Query: 1178 FPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENG-----DLSPFSGTSLRERG 1232
P + L+TGYR VPL++ E L ASL + + I + G LS G RE
Sbjct: 721 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 780
Query: 1233 S 1233
S
Sbjct: 781 S 781
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 193 bits (491), Expect = 8e-49
Identities = 117/307 (38%), Positives = 162/307 (52%), Gaps = 14/307 (4%)
Query: 249 VSLPEFQQFLLDYQGELWAVDRLQ--VQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKE 306
V + + FL++ QGE D + +Q+F S + + + F FL KE
Sbjct: 1324 VGILQLNDFLVNCQGEHCTYDEILSIIQKFEPS-----ISMCHQGLMSFEGFARFLMDKE 1378
Query: 307 NSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIEL 366
N + + PLS+Y+I SSHNTYLTG Q ESS+E Y++ L GCR +EL
Sbjct: 1379 NFASKNDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVEL 1438
Query: 367 DCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMA 426
DCWDG DGMP+IYHGHTLTTKI F +V+ I AF+ S+ P+I+SIE+HCS+ QQR MA
Sbjct: 1439 DCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMA 1498
Query: 427 QYFKKVLGDTLLTK---PVEISADG-LPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYS 482
+ FK V G+ L+TK + S D LPSP+QL++K+L+K+KKL ++ +
Sbjct: 1499 EIFKTVFGEKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQ 1558
Query: 483 ENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSST 542
+ NG P N+E Y E S D ED E K +
Sbjct: 1559 LASMQVQAYNGGNANPRPANNEEEEDE---EDEYDYDYESLSDDNILEDRPENKSCNDKL 1615
Query: 543 ELHSNEK 549
+ NE+
Sbjct: 1616 QFEYNEE 1622
Score = 141 bits (355), Expect = 5e-33
Identities = 87/239 (36%), Positives = 131/239 (54%), Gaps = 16/239 (6%)
Query: 976 CYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQL 1035
CY +SS E A++ + +K Q+ QL R YP R+DSSN +PL W+ G QL
Sbjct: 1754 CYH-ISSLNENAAKRLCRRYS-QKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQL 1811
Query: 1036 VALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRD------EAFDPFDKSSLRGLEPCA 1089
VALN+QT D P+ +N A+F CGYVL+P + D + F P ++ L ++P
Sbjct: 1812 VALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLER-DLDSMDPAV 1870
Query: 1090 ISIEVLGARHL-PKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQ 1148
S+ ++ +++ P N G C +E++V G DS +T+ + N LNP+W + F F
Sbjct: 1871 YSLTIVSGQNVCPSNSMGSPC--IEVDVLGMPLDSCHFRTKPIHRNTLNPMW-NEQFLFH 1927
Query: 1149 ISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLI 1207
+ + FLRF V E + AQ P+K LK GYR + L+N ++E LE++SL I
Sbjct: 1928 VHFEDLVFLRFAVVEN---NSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFI 1983
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 185 bits (470), Expect = 2e-46
Identities = 109/299 (36%), Positives = 171/299 (57%), Gaps = 15/299 (5%)
Query: 944 ERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQY 1003
+++ ++ ELS+LV C+ V + + ++ + Y +M SF ET+A + N+ + F+ Y
Sbjct: 576 QKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYP-EDFVNY 634
Query: 1004 NRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYV 1063
N+ LSRIYP R+DSSN +P W CG Q+VA+NFQTP M ++ F+ CGYV
Sbjct: 635 NKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYV 694
Query: 1064 LQPSTMRDEA--FDPFDKSSLRGLEPCAISIEVLGARHLPKN----GRG-IVCPFVEIEV 1116
L+PS MRDE F K L G+ P A+ I+++ ++ PK +G ++ P+V IE+
Sbjct: 695 LRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEI 754
Query: 1117 AGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQA 1176
G D ++Q+T+ V N NP++ + F FQ++ PE A +RFVV ++D D+ F+ Q
Sbjct: 755 HGIPADCSEQRTKTVQQNSDNPIFD-ETFEFQVNLPELAMIRFVVLDDDYIGDE-FIGQY 812
Query: 1177 TFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENG-----DLSPFSGTSLRE 1230
T P + L+ GYR VPL++ + +E +L + I I G LS G +RE
Sbjct: 813 TIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVRE 871
Score = 185 bits (469), Expect = 3e-46
Identities = 137/448 (30%), Positives = 217/448 (48%), Gaps = 50/448 (11%)
Query: 41 KKSQRPERKTFQVKLETRQITWSRGADKIEGA-IDIREIKEIRPGKTSRDF------DRY 93
+ + R + F + + + + W +E A +DI IKEIR GK + F D+
Sbjct: 125 RPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQI 184
Query: 94 QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQI 153
ED AF IL+G + ++L L A S D N+W+ GL +L+ + Q ++
Sbjct: 185 CEDCAFS--------ILHGENY--ESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEG 234
Query: 154 ER------WLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGD 207
+ WL+ F + D + + ++ Q+N P ++ + RL
Sbjct: 235 NQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLN---PTLKEAKIRL--------- 282
Query: 208 ITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPEL--CRVSLPEFQQFLLDYQGEL 265
+F ++ +S + + F EA RPE+ V + + +++L L
Sbjct: 283 ----KFKEIQKSKEKLTTRVTEEEFCEAFC-ELCTRPEVYFLLVQISKNKEYLDANDLML 337
Query: 266 WAVDRLQVQEFMLSFLRDPLREIE-------EPYFFLDEFVTFLFSKENSVWNSQLDAVC 318
+ V D +R E + + +D F +L S E +++ + V
Sbjct: 338 FLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVA 397
Query: 319 PDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVI 378
D M PLSHY+I++SHNTYL DQF + + Y R L+MGCR +ELD DG D P++
Sbjct: 398 QD-MTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPIL 456
Query: 379 YHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLL 438
+ + +TT + F V+ I + AFVASEYP+IL + +HCS+ QQ+ MAQ KKV G+ L
Sbjct: 457 CNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLY 516
Query: 439 TKPVEISADGLPSPNQLKRKILIKHKKL 466
T+ S LPSP +LKR I++K KKL
Sbjct: 517 TEAPLPSESYLPSPEKLKRMIIVKGKKL 544
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 185 bits (470), Expect = 2e-46
Identities = 109/299 (36%), Positives = 171/299 (57%), Gaps = 15/299 (5%)
Query: 944 ERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQY 1003
+++ ++ ELS+LV C+ V + + ++ + Y +M SF ET+A + N+ + F+ Y
Sbjct: 478 QKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYP-EDFVNY 536
Query: 1004 NRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYV 1063
N+ LSRIYP R+DSSN +P W CG Q+VA+NFQTP M ++ F+ CGYV
Sbjct: 537 NKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYV 596
Query: 1064 LQPSTMRDEA--FDPFDKSSLRGLEPCAISIEVLGARHLPKN----GRG-IVCPFVEIEV 1116
L+PS MRDE F K L G+ P A+ I+++ ++ PK +G ++ P+V IE+
Sbjct: 597 LRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEI 656
Query: 1117 AGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQA 1176
G D ++Q+T+ V N NP++ + F FQ++ PE A +RFVV ++D D+ F+ Q
Sbjct: 657 HGIPADCSEQRTKTVQQNSDNPIFD-ETFEFQVNLPELAMIRFVVLDDDYIGDE-FIGQY 714
Query: 1177 TFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENG-----DLSPFSGTSLRE 1230
T P + L+ GYR VPL++ + +E +L + I I G LS G +RE
Sbjct: 715 TIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVRE 773
Score = 185 bits (469), Expect = 3e-46
Identities = 137/448 (30%), Positives = 217/448 (48%), Gaps = 50/448 (11%)
Query: 41 KKSQRPERKTFQVKLETRQITWSRGADKIEGA-IDIREIKEIRPGKTSRDF------DRY 93
+ + R + F + + + + W +E A +DI IKEIR GK + F D+
Sbjct: 27 RPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQI 86
Query: 94 QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQI 153
ED AF IL+G + ++L L A S D N+W+ GL +L+ + Q ++
Sbjct: 87 CEDCAFS--------ILHGENY--ESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEG 136
Query: 154 ER------WLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGD 207
+ WL+ F + D + + ++ Q+N P ++ + RL
Sbjct: 137 NQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLN---PTLKEAKIRL--------- 184
Query: 208 ITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPEL--CRVSLPEFQQFLLDYQGEL 265
+F ++ +S + + F EA RPE+ V + + +++L L
Sbjct: 185 ----KFKEIQKSKEKLTTRVTEEEFCEAFC-ELCTRPEVYFLLVQISKNKEYLDANDLML 239
Query: 266 WAVDRLQVQEFMLSFLRDPLREIE-------EPYFFLDEFVTFLFSKENSVWNSQLDAVC 318
+ V D +R E + + +D F +L S E +++ + V
Sbjct: 240 FLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVA 299
Query: 319 PDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVI 378
D M PLSHY+I++SHNTYL DQF + + Y R L+MGCR +ELD DG D P++
Sbjct: 300 QD-MTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPIL 358
Query: 379 YHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLL 438
+ + +TT + F V+ I + AFVASEYP+IL + +HCS+ QQ+ MAQ KKV G+ L
Sbjct: 359 CNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLY 418
Query: 439 TKPVEISADGLPSPNQLKRKILIKHKKL 466
T+ S LPSP +LKR I++K KKL
Sbjct: 419 TEAPLPSESYLPSPEKLKRMIIVKGKKL 446
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 174 bits (442), Expect = 4e-43
Identities = 115/325 (35%), Positives = 165/325 (50%), Gaps = 58/325 (17%)
Query: 296 DEFVTFLFSKENS-VWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYA 354
D F +L S EN+ V+ +L+ M++PL+HY+ISSSHNTYLTG QF +SS+E Y
Sbjct: 290 DGFCRYLMSDENAPVFLDRLELY--QEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYR 347
Query: 355 RCLRMGCRCIELDCWD--GPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS 412
+ L GCRC+ELDCWD G D P+I HG + T I F DV+ IKE AFV SEYPVILS
Sbjct: 348 QVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILS 407
Query: 413 IEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEI----SADGLPSPNQLKRKILIKHKKLAE 468
E+HCS QQ M++Y + + GD LL + +E LPSPN LKRKILIK+K+L
Sbjct: 408 FENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKP 467
Query: 469 GSAYEEV--------------PTSMMYSEND----------------------------- 485
+++ P +++ +N+
Sbjct: 468 EVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGH 527
Query: 486 ---ISNSIKNGILYLEDPVNHEWYPHY-FVLTSSKIYYSEETSSDQGNEDEEEPKEVSSS 541
++NS+K G++ +ED W Y +V ++ I+ T + + + V+
Sbjct: 528 KEAVANSVKKGLVTVED--EQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEE 585
Query: 542 TELHSNEKWFHGKLGAGRDGRHIAE 566
+H N F+ +G G H E
Sbjct: 586 RNIHYNMSSFNESVGLGYLKTHAIE 610
Score = 172 bits (437), Expect = 1e-42
Identities = 104/299 (34%), Positives = 164/299 (54%), Gaps = 13/299 (4%)
Query: 916 QEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERA 975
+E + + VKK + A + K + I LS ++ Y +PV F + ER
Sbjct: 528 KEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERN 587
Query: 976 CYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQL 1035
+ +MSSF E+ Y+ K +F+ YN+ Q+SRIYPKG R+DSSNY P W G Q+
Sbjct: 588 IHYNMSSFNESVGLGYL-KTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQM 646
Query: 1036 VALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR--DEAFDPFDKSSLRGLEPCAISIE 1093
V+LN+QTPD MQ+NQ F CGY+L+P MR D FDPF ++ + G+ S++
Sbjct: 647 VSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQ 706
Query: 1094 VLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ--KTEFVVDNGLNPVWPAKPFHF-QIS 1150
V+ + L G +VE+++ G D+ ++ +T V++NGLNPV+ + F F ++
Sbjct: 707 VISGQFLSDKKIG---TYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVI 763
Query: 1151 NPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKI 1209
P+ A LR VY++ + + Q P+ GL+ GYR + L+N ++ L L ++ I
Sbjct: 764 LPDLAVLRIAVYDD----NNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNI 818
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 174 bits (442), Expect = 4e-43
Identities = 115/325 (35%), Positives = 165/325 (50%), Gaps = 58/325 (17%)
Query: 296 DEFVTFLFSKENS-VWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYA 354
D F +L S EN+ V+ +L+ M++PL+HY+ISSSHNTYLTG QF +SS+E Y
Sbjct: 290 DGFCRYLMSDENAPVFLDRLELY--QEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYR 347
Query: 355 RCLRMGCRCIELDCWD--GPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS 412
+ L GCRC+ELDCWD G D P+I HG + T I F DV+ IKE AFV SEYPVILS
Sbjct: 348 QVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILS 407
Query: 413 IEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEI----SADGLPSPNQLKRKILIKHKKLAE 468
E+HCS QQ M++Y + + GD LL + +E LPSPN LKRKILIK+K+L
Sbjct: 408 FENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKP 467
Query: 469 GSAYEEV--------------PTSMMYSEND----------------------------- 485
+++ P +++ +N+
Sbjct: 468 EVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGH 527
Query: 486 ---ISNSIKNGILYLEDPVNHEWYPHY-FVLTSSKIYYSEETSSDQGNEDEEEPKEVSSS 541
++NS+K G++ +ED W Y +V ++ I+ T + + + V+
Sbjct: 528 KEAVANSVKKGLVTVED--EQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEE 585
Query: 542 TELHSNEKWFHGKLGAGRDGRHIAE 566
+H N F+ +G G H E
Sbjct: 586 RNIHYNMSSFNESVGLGYLKTHAIE 610
Score = 172 bits (437), Expect = 1e-42
Identities = 104/299 (34%), Positives = 164/299 (54%), Gaps = 13/299 (4%)
Query: 916 QEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERA 975
+E + + VKK + A + K + I LS ++ Y +PV F + ER
Sbjct: 528 KEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERN 587
Query: 976 CYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQL 1035
+ +MSSF E+ Y+ K +F+ YN+ Q+SRIYPKG R+DSSNY P W G Q+
Sbjct: 588 IHYNMSSFNESVGLGYL-KTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQM 646
Query: 1036 VALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR--DEAFDPFDKSSLRGLEPCAISIE 1093
V+LN+QTPD MQ+NQ F CGY+L+P MR D FDPF ++ + G+ S++
Sbjct: 647 VSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQ 706
Query: 1094 VLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ--KTEFVVDNGLNPVWPAKPFHF-QIS 1150
V+ + L G +VE+++ G D+ ++ +T V++NGLNPV+ + F F ++
Sbjct: 707 VISGQFLSDKKIG---TYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVI 763
Query: 1151 NPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKI 1209
P+ A LR VY++ + + Q P+ GL+ GYR + L+N ++ L L ++ I
Sbjct: 764 LPDLAVLRIAVYDD----NNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNI 818
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 174 bits (440), Expect = 6e-43
Identities = 103/313 (32%), Positives = 168/313 (53%), Gaps = 16/313 (5%)
Query: 155 RWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFA 214
RW + D R +I+ + + +L +++ R + + + + G IT +F
Sbjct: 4 RWFLSKIQ--DDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFR 61
Query: 215 QLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQ 274
+YR + + + +E + R L +L +F E +A + +
Sbjct: 62 AIYRIITHREE------IIEIFNTYSENRKILLASNLAQF------LTQEQYAAEMSKAI 109
Query: 275 EFMLSFLRDPLREIEEPY-FFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISS 333
F + +P+ E+ + + L+ F ++ S+E ++ ++ V D M +PL+ Y+ISS
Sbjct: 110 AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQD-MTHPLNDYFISS 168
Query: 334 SHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDV 393
SHNTYL DQ S L Y L GCRC+E+DCWDG PV+YHG+TLT+K+ F V
Sbjct: 169 SHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTV 228
Query: 394 LHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADGLPSPN 453
+ I ++AF+ S+YPV+LS+E+HCS AQQ MA + G++LL+ ++ D LPSP
Sbjct: 229 IQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPE 288
Query: 454 QLKRKILIKHKKL 466
LK KIL+K+KK+
Sbjct: 289 ALKFKILVKNKKI 301
Score = 153 bits (386), Expect = 1e-36
Identities = 95/269 (35%), Positives = 145/269 (53%), Gaps = 9/269 (3%)
Query: 945 RRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYN 1004
R+ KIAL LS+LV+Y + F + + + +S ET+A K ++K + +F+ +
Sbjct: 341 RKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARK-LSKLRVHEFIFHT 399
Query: 1005 RLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVL 1064
R ++RIYPK R DSSN++P W G Q+VALNFQTP PM + F+ GY+L
Sbjct: 400 RKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYIL 459
Query: 1065 QPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLP----KNGRGIVCPFVEIEVAGAE 1120
+P +R E+ F+ S+++ P ++I ++ LP + +G V IEV G
Sbjct: 460 KPHFLR-ESKSYFNPSNIKEGMPITLTIRLISGIQLPLTHSSSNKG--DSLVIIEVFGVP 516
Query: 1121 YDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPV 1180
D KQ+T + N +P W + F F I PE A +RFVV + + + FL Q T P+
Sbjct: 517 NDQMKQQTRVIKKNAFSPRW-NETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPL 575
Query: 1181 KGLKTGYRAVPLKNNYSEDLELASLLIKI 1209
+ GYR +PL + E LE ASL + +
Sbjct: 576 LCMNKGYRRIPLFSRMGESLEPASLFVYV 604
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 166 bits (419), Expect = 2e-40
Identities = 112/302 (37%), Positives = 160/302 (52%), Gaps = 22/302 (7%)
Query: 910 DVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEK 969
D D +EE Q KK TA + + + E+S LV Y PV F +
Sbjct: 557 DEEEDEEEEEQTDPKKPTTDEGTASSEVNATE----------EMSTLVNYIEPVKFKSFE 606
Query: 970 IGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMW 1029
+R +MSSF ETKA + + K+ +F++YN+ QLSRIYPKG R+DSSNY P W
Sbjct: 607 AARKRNKCFEMSSFVETKAMEQLTKSP-MEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFW 665
Query: 1030 ICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR--DEAFDPFDKSSLRGLEP 1087
G QLVALNFQT D MQ+N +F GY+L+P MR D++FDPF + + G+
Sbjct: 666 NVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVA 725
Query: 1088 CAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDS-TKQKTEFVVDNGLNPVWPAKPFH 1146
A+ ++V+ + L GI +VE+++ G D+ K +T N NPVW +PF
Sbjct: 726 NALRVKVISGQFLSDRKVGI---YVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFD 782
Query: 1147 F-QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASL 1205
F ++ P A LR +EE F+ PV +++GY V L+N ++ L L +L
Sbjct: 783 FPKVVLPTLASLRIAAFEE----GGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPAL 838
Query: 1206 LI 1207
LI
Sbjct: 839 LI 840
Score = 145 bits (365), Expect = 3e-34
Identities = 127/426 (29%), Positives = 195/426 (45%), Gaps = 38/426 (8%)
Query: 73 IDIREIKEIRPGKTSRDFDRYQEDPAFR-------PD---QSHCFVILYGME-FRLKTLS 121
+D +I IR +T R + R +DP R PD + ++ G + L+
Sbjct: 61 VDTLDISSIRDTRTGR-YARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLN 119
Query: 122 LQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQF--YSVDRNREDRISAKDLKN 179
A +D +W + L L + L +LRK + + N++ RI K++
Sbjct: 120 FMAVQDDTAKVWSEELFKLAMNILAQNASRNT--FLRKAYTKLKLQVNQDGRIPVKNILK 177
Query: 180 MLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFA-QLYRSLMYSAQKTMDLPFLEASTL 238
M S RV E RS I +F+ +++ + K P ++ L
Sbjct: 178 MFSADKKRVETAL---ESCGLKFNRSESIRPDEFSLEIFERFL---NKLCLRPDIDKILL 231
Query: 239 RAGERPELCRVSLPEFQQFLLDYQGE------LWAVDRLQVQEFMLSFLRDPLREIEEPY 292
G + + ++L + F+ Q + L+ R ++ + +E
Sbjct: 232 EIGAKGKPY-LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQ 290
Query: 293 FFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEA 352
++ F +L +EN + + + D M PLS Y+I+SSHNTYLT Q + SS+E
Sbjct: 291 MSMEGFSRYLGGEENGILPLEALDLSTD-MTQPLSAYFINSSHNTYLTAGQLAGTSSVEM 349
Query: 353 YARCLRMGCRCIELDCWDG--PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVI 410
Y + L GCRC+ELD W G P+ P I HG T+TT++ DVL I E AF S YPVI
Sbjct: 350 YRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVI 409
Query: 411 LSIEDHC-SIAQQRNMAQYFKKVLGDTLLTKPVE----ISADGLPSPNQLKRKILIKHKK 465
LS E+H S QQ MA+Y + + GD LL +P++ LPSP L +IL+K+KK
Sbjct: 410 LSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKK 469
Query: 466 LAEGSA 471
SA
Sbjct: 470 RHRPSA 475
>gi|12083581 phosphoinositide-specific phospholipase C beta 1 isoform
a [Homo sapiens]
Length = 1216
Score = 164 bits (416), Expect = 4e-40
Identities = 97/265 (36%), Positives = 152/265 (57%), Gaps = 13/265 (4%)
Query: 952 ELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRI 1011
E+S LV Y +PV F+ +I +R +MSSF ETK + + K+ +F++YN++QLSRI
Sbjct: 539 EMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSP-VEFVEYNKMQLSRI 597
Query: 1012 YPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR- 1070
YPKG R+DSSNY P W G Q+VALNFQT D MQ+N ++ GY L+P MR
Sbjct: 598 YPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRR 657
Query: 1071 -DEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ--K 1127
D+ FDPF + + G+ +S++++ + L G +VE+++ G D+ ++ K
Sbjct: 658 PDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVG---TYVEVDMFGLPVDTRRKAFK 714
Query: 1128 TEFVVDNGLNPVWPAKPFHF-QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTG 1186
T+ N +NPVW +P F ++ P A LR VYEE F+ PV+ ++ G
Sbjct: 715 TKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEE----GGKFIGHRILPVQAIRPG 770
Query: 1187 YRAVPLKNNYSEDLELASLLIKIDI 1211
Y + L+N ++ L L ++ + I++
Sbjct: 771 YHYICLRNERNQPLTLPAVFVYIEV 795
Score = 150 bits (380), Expect = 6e-36
Identities = 88/205 (42%), Positives = 125/205 (60%), Gaps = 12/205 (5%)
Query: 295 LDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYA 354
+D F+ +L +EN V + + + D M+ PLSHY+I+SSHNTYLT Q + SS+E Y
Sbjct: 292 VDGFMRYLSGEENGVVSPEKLDLNED-MSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYR 350
Query: 355 RCLRMGCRCIELDCWDG--PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS 412
+ L GCRC+ELDCW G + PVI HG T+TT+I F +V+ I E AF S +P++LS
Sbjct: 351 QVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLS 410
Query: 413 IEDHC-SIAQQRNMAQYFKKVLGDTLLTKPVE----ISADGLPSPNQLKRKILIKHK--- 464
E+H S QQ MA+Y + + GD LL +P+E S LPSP L KIL+K+K
Sbjct: 411 FENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKS 470
Query: 465 -KLAEGSAYEEVPTSMMYSENDISN 488
K +EGS +++ + +D S+
Sbjct: 471 HKSSEGSGKKKLSEQASNTYSDSSS 495
>gi|33356544 phosphoinositide-specific phospholipase C beta 1 isoform
b [Homo sapiens]
Length = 1173
Score = 164 bits (416), Expect = 4e-40
Identities = 97/265 (36%), Positives = 152/265 (57%), Gaps = 13/265 (4%)
Query: 952 ELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRI 1011
E+S LV Y +PV F+ +I +R +MSSF ETK + + K+ +F++YN++QLSRI
Sbjct: 539 EMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSP-VEFVEYNKMQLSRI 597
Query: 1012 YPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR- 1070
YPKG R+DSSNY P W G Q+VALNFQT D MQ+N ++ GY L+P MR
Sbjct: 598 YPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRR 657
Query: 1071 -DEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ--K 1127
D+ FDPF + + G+ +S++++ + L G +VE+++ G D+ ++ K
Sbjct: 658 PDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVG---TYVEVDMFGLPVDTRRKAFK 714
Query: 1128 TEFVVDNGLNPVWPAKPFHF-QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTG 1186
T+ N +NPVW +P F ++ P A LR VYEE F+ PV+ ++ G
Sbjct: 715 TKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEE----GGKFIGHRILPVQAIRPG 770
Query: 1187 YRAVPLKNNYSEDLELASLLIKIDI 1211
Y + L+N ++ L L ++ + I++
Sbjct: 771 YHYICLRNERNQPLTLPAVFVYIEV 795
Score = 150 bits (380), Expect = 6e-36
Identities = 88/205 (42%), Positives = 125/205 (60%), Gaps = 12/205 (5%)
Query: 295 LDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYA 354
+D F+ +L +EN V + + + D M+ PLSHY+I+SSHNTYLT Q + SS+E Y
Sbjct: 292 VDGFMRYLSGEENGVVSPEKLDLNED-MSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYR 350
Query: 355 RCLRMGCRCIELDCWDG--PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS 412
+ L GCRC+ELDCW G + PVI HG T+TT+I F +V+ I E AF S +P++LS
Sbjct: 351 QVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLS 410
Query: 413 IEDHC-SIAQQRNMAQYFKKVLGDTLLTKPVE----ISADGLPSPNQLKRKILIKHK--- 464
E+H S QQ MA+Y + + GD LL +P+E S LPSP L KIL+K+K
Sbjct: 411 FENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKS 470
Query: 465 -KLAEGSAYEEVPTSMMYSENDISN 488
K +EGS +++ + +D S+
Sbjct: 471 HKSSEGSGKKKLSEQASNTYSDSSS 495
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 155 bits (391), Expect = 3e-37
Identities = 105/260 (40%), Positives = 131/260 (50%), Gaps = 38/260 (14%)
Query: 299 VTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLR 358
V FL ENSV +Q + M PL+HY+I+SSHNTYLT QFS SS E Y + L
Sbjct: 292 VWFLCGPENSVL-AQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLL 350
Query: 359 MGCRCIELDCWDG--PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDH 416
GCRC+ELDCW G PD P+I HG T+TT I F + + I E AF S YP+ILS E+H
Sbjct: 351 SGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENH 410
Query: 417 C-SIAQQRNMAQYFKKVLGDTLLTKPVE----ISADGLPSPNQLKRKILIKHKKL----- 466
S QQ MA+Y + + GD LLT+P+E LPSP L+ KILIK+KK
Sbjct: 411 VDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGP 470
Query: 467 ------AEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYS 520
G A P S E + + L E+
Sbjct: 471 TSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEE-------------------VE 511
Query: 521 EETSSDQGNEDEEEPKEVSS 540
EE + GN DEEE K++ S
Sbjct: 512 EEEEEESGNLDEEEIKKMQS 531
Score = 147 bits (372), Expect = 5e-35
Identities = 97/265 (36%), Positives = 142/265 (53%), Gaps = 13/265 (4%)
Query: 952 ELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRI 1011
E+S LV Y +P F + ++ +SSF E KA ++KA +F+ YN+ Q+SRI
Sbjct: 545 EMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKAS-VQFVDYNKRQMSRI 603
Query: 1012 YPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR- 1070
YPKG R+DSSNY P W G Q+VALNFQT D PMQ N A+F GY+L+ MR
Sbjct: 604 YPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRR 663
Query: 1071 -DEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ-KT 1128
D+ F+PF + + +SI V+ + L + V +VE+E+ G D ++ +T
Sbjct: 664 PDKQFNPFSVDRIDVVVATTLSITVISGQFLSERS---VRTYVEVELFGLPGDPKRRYRT 720
Query: 1129 EFVVD-NGLNPVWPAKPFHFQ-ISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTG 1186
+ N +NPVW +PF F+ I PE A LR V EE FL P+ L +G
Sbjct: 721 KLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEE----GNKFLGHRIIPINALNSG 776
Query: 1187 YRAVPLKNNYSEDLELASLLIKIDI 1211
Y + L + + L + +L I +++
Sbjct: 777 YHHLCLHSESNMPLTMPALFIFLEM 801
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 85.9 bits (211), Expect = 2e-16
Identities = 67/230 (29%), Positives = 112/230 (48%), Gaps = 32/230 (13%)
Query: 546 SNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKV 605
++ +WFH + AE LL T DGSFL R S++ GD+TLS RNG V
Sbjct: 2 TSRRWFHPNITGVE-----AENLLL-----TRGVDGSFLARPSKSNPGDFTLSVRRNGAV 51
Query: 606 QHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHE- 664
H +I + D + L F +L +L+ +Y + + E + E N +
Sbjct: 52 THIKIQNTGD----YYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADP 107
Query: 665 -SKEWYHASLTRAQAEHMLMRVPRDGAFLVRK-RNEPNSYAISFR----------AEGKI 712
S+ W+H L+ +AE +L + G+FLVR+ ++ P + +S R + K+
Sbjct: 108 TSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKV 167
Query: 713 KHCRVQ-QEGQTVMLGNSEFDSLVDLISYYEKHPLYRK----MKLRYPIN 757
H ++ QE + + G FDSL DL+ +Y+K+P+ ++L+ P+N
Sbjct: 168 THVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLN 217
>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 287
Score = 80.1 bits (196), Expect = 1e-14
Identities = 60/201 (29%), Positives = 97/201 (48%), Gaps = 25/201 (12%)
Query: 657 VPQTNAHESKEWYHASLTRAQAE-HMLMRVPRDGAFLVRKR-NEPNSYAISFRAEGKIKH 714
VP+ + + WY ++ R QAE ++ RV + +LVR R E YAIS + + KH
Sbjct: 101 VPKPVDYSCQPWYAGAMERLQAETELINRV--NSTYLVRHRTKESGEYAISIKYNNEAKH 158
Query: 715 CRV-QQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMK-----LRYPINEEALEKIGTAE 768
++ ++G + N +F SL++L+ YY+ H L + L++P E
Sbjct: 159 IKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYK----------E 208
Query: 769 PDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQE-GG 827
P++ A G G + P A +D+ A+ EL+ +K +++ K G
Sbjct: 209 PEHSAGQRGNRAG---NSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANG 265
Query: 828 WWRGDYGGKKQLWFPSNYVEE 848
WWRG+ G+ WFPS YVEE
Sbjct: 266 WWRGEVNGRVG-WFPSTYVEE 285
Score = 33.5 bits (75), Expect = 1.4
Identities = 18/66 (27%), Positives = 34/66 (51%), Gaps = 4/66 (6%)
Query: 580 DGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHY 639
+ ++LVR G+Y +S N + +H +I +R F + +N F SL +L+ +Y
Sbjct: 131 NSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGF----FHIAENRKFKSLMELVEYY 186
Query: 640 QQVPLR 645
+ L+
Sbjct: 187 KHHSLK 192
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 80.1 bits (196), Expect = 1e-14
Identities = 60/201 (29%), Positives = 97/201 (48%), Gaps = 25/201 (12%)
Query: 657 VPQTNAHESKEWYHASLTRAQAE-HMLMRVPRDGAFLVRKR-NEPNSYAISFRAEGKIKH 714
VP+ + + WY ++ R QAE ++ RV + +LVR R E YAIS + + KH
Sbjct: 661 VPKPVDYSCQPWYAGAMERLQAETELINRV--NSTYLVRHRTKESGEYAISIKYNNEAKH 718
Query: 715 CRV-QQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMK-----LRYPINEEALEKIGTAE 768
++ ++G + N +F SL++L+ YY+ H L + L++P E
Sbjct: 719 IKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYK----------E 768
Query: 769 PDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQE-GG 827
P++ A G G + P A +D+ A+ EL+ +K +++ K G
Sbjct: 769 PEHSAGQRGNRAG---NSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANG 825
Query: 828 WWRGDYGGKKQLWFPSNYVEE 848
WWRG+ G+ WFPS YVEE
Sbjct: 826 WWRGEVNGRVG-WFPSTYVEE 845
Score = 33.5 bits (75), Expect = 1.4
Identities = 18/66 (27%), Positives = 34/66 (51%), Gaps = 4/66 (6%)
Query: 580 DGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHY 639
+ ++LVR G+Y +S N + +H +I +R F + +N F SL +L+ +Y
Sbjct: 691 NSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGF----FHIAENRKFKSLMELVEYY 746
Query: 640 QQVPLR 645
+ L+
Sbjct: 747 KHHSLK 752
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 75.1 bits (183), Expect = 4e-13
Identities = 63/212 (29%), Positives = 99/212 (46%), Gaps = 33/212 (15%)
Query: 646 CNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKR-NEPNSYAI 704
CN + + P + H WY + RA AE +L DG FLVR+R + +AI
Sbjct: 652 CNRVKPYVHGPPQDLSVHL---WYAGPMERAGAESILAN-RSDGTFLVRQRVKDAAEFAI 707
Query: 705 SFRAEGKIKHCRVQ-QEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMK-----LRYPINE 758
S + ++KH ++ EG + F L +L+ +Y+++ L K L++P E
Sbjct: 708 SIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKE 767
Query: 759 EALEKIGTAEPDYGAL-YEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAI 817
EK + P G+ Y G KA +D+ A+ EL+ + I
Sbjct: 768 P--EKRTISRPAVGSTKYFG-----------------TAKARYDFCARDRSELSLKEGDI 808
Query: 818 IQNVEKQ-EGGWWRGDYGGKKQLWFPSNYVEE 848
I+ + K+ + GWWRG+ G+ WFP+NYVEE
Sbjct: 809 IKILNKKGQQGWWRGEIYGRVG-WFPANYVEE 839
Score = 34.3 bits (77), Expect = 0.79
Identities = 19/66 (28%), Positives = 35/66 (53%), Gaps = 4/66 (6%)
Query: 580 DGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHY 639
DG+FLVR+ ++ +S N +V+H +I + + + +T+ F L +L+ Y
Sbjct: 690 DGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGL----YRITEKKAFRGLTELVEFY 745
Query: 640 QQVPLR 645
QQ L+
Sbjct: 746 QQNSLK 751
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 71.6 bits (174), Expect = 4e-12
Identities = 57/221 (25%), Positives = 106/221 (47%), Gaps = 29/221 (13%)
Query: 653 LSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRN-EPNSYAISFRAEGK 711
+S P + + + W+ ++ R Q +++L + G +L+R+R E +AIS + +
Sbjct: 658 ISRPPSREIDYTAYPWFAGNMERQQTDNLL-KSHASGTYLIRERPAEAERFAISIKFNDE 716
Query: 712 IKHCRVQQEGQTVMLGNS-EFDSLVDLISYYEKHPLYRKMK-----LRYPI--NEEALEK 763
+KH +V ++ + + + +FDSL++L+ YY+ H L K L+YP E + +
Sbjct: 717 VKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASR 776
Query: 764 IGTAEPDYGALY--------------EGRNPGFYVEANPMPTFKCAVKALFDYKAQREDE 809
+ P A Y +G + F+ P AV A +++ A+ E
Sbjct: 777 ASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPR-VIGTAV-ARYNFAARDMRE 834
Query: 810 LTFIKSAIIQNVEKQEG--GWWRGDYGGKKQLWFPSNYVEE 848
L+ + +++ + G GWW+G+ G+ WFPS YVEE
Sbjct: 835 LSLREGDVVRIYSRIGGDQGWWKGETNGRIG-WFPSTYVEE 874
Score = 33.5 bits (75), Expect = 1.4
Identities = 23/91 (25%), Positives = 44/91 (48%), Gaps = 15/91 (16%)
Query: 550 WFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCR 609
WF G + ER T+ +++ A G++L+RE + +S N +V+H +
Sbjct: 673 WFAGNM----------ERQQTDNLLKSHA-SGTYLIRERPAEAERFAISIKFNDEVKHIK 721
Query: 610 IHSRQDAGTPKFFLTDNLVFDSLYDLITHYQ 640
+ + + +T+ FDSL +L+ +YQ
Sbjct: 722 VVEKDN----WIHITEAKKFDSLLELVEYYQ 748
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 71.2 bits (173), Expect = 6e-12
Identities = 52/205 (25%), Positives = 97/205 (47%), Gaps = 26/205 (12%)
Query: 653 LSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRN-EPNSYAISFRAEGK 711
+S P + + + W+ ++ R Q +++L + G +L+R+R E +AIS + +
Sbjct: 648 ISRPPSREIDYTAYPWFAGNMERQQTDNLL-KSHASGTYLIRERPAEAERFAISIKFNDE 706
Query: 712 IKHCRVQQEGQTVMLGNS-EFDSLVDLISYYEKHPLYRKMK-----LRYPINEEALEKIG 765
+KH +V ++ + + + +FDSL++L+ YY+ H L K L+YP
Sbjct: 707 VKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERS--- 763
Query: 766 TAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQE 825
+ R+P F P A +++ A+ EL+ + +++ +
Sbjct: 764 ------ASRASSRSPVF------TPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIG 811
Query: 826 G--GWWRGDYGGKKQLWFPSNYVEE 848
G GWW+G+ G+ WFPS YVEE
Sbjct: 812 GDQGWWKGETNGRIG-WFPSTYVEE 835
Score = 33.5 bits (75), Expect = 1.4
Identities = 23/91 (25%), Positives = 44/91 (48%), Gaps = 15/91 (16%)
Query: 550 WFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCR 609
WF G + ER T+ +++ A G++L+RE + +S N +V+H +
Sbjct: 663 WFAGNM----------ERQQTDNLLKSHA-SGTYLIRERPAEAERFAISIKFNDEVKHIK 711
Query: 610 IHSRQDAGTPKFFLTDNLVFDSLYDLITHYQ 640
+ + + +T+ FDSL +L+ +YQ
Sbjct: 712 VVEKDN----WIHITEAKKFDSLLELVEYYQ 738
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 71.2 bits (173), Expect = 6e-12
Identities = 50/182 (27%), Positives = 90/182 (49%), Gaps = 30/182 (16%)
Query: 668 WYHASLTRAQAEHMLMRVPRDGAFLVRK-RNEPNSYAISFRAEGKIKHCRVQQEGQ-TVM 725
WY ++R AE +LM+ GAFL+R+ + P +++S +++H +V +E
Sbjct: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYF 119
Query: 726 LGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVE 785
L +F+SL +L+ +Y + +K ++ + +EE L K +PG
Sbjct: 120 LWEEKFNSLNELVDFYRTTTIAKKRQI-FLRDEEPLLK---------------SPG---- 159
Query: 786 ANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNY 845
C +A FD+ AQ +L+F + II+ +E+ + WWRG G+ +FP +Y
Sbjct: 160 -------ACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVG-FFPRSY 211
Query: 846 VE 847
V+
Sbjct: 212 VQ 213
Score = 39.3 bits (90), Expect = 0.025
Identities = 31/102 (30%), Positives = 58/102 (56%), Gaps = 10/102 (9%)
Query: 557 AGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDA 616
+GR R +AE +L + G+FL+RESE+ G++++S +VQH ++ R+ +
Sbjct: 62 SGRISRQLAEEILMKR-----NHLGAFLIRESESSPGEFSVSVNYGDQVQHFKV-LREAS 115
Query: 617 GTPKFFLTDNLVFDSLYDLITHYQQVPL-RCNEFEMRLSEPV 657
G K+FL + F+SL +L+ Y+ + + + +R EP+
Sbjct: 116 G--KYFLWEE-KFNSLNELVDFYRTTTIAKKRQIFLRDEEPL 154
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,256,041
Number of Sequences: 37866
Number of extensions: 2325275
Number of successful extensions: 6815
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 166
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 5996
Number of HSP's gapped (non-prelim): 684
length of query: 1290
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1176
effective length of database: 13,930,794
effective search space: 16382613744
effective search space used: 16382613744
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.