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Search of human proteins with 33589848
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33589848 transferrin receptor 2 [Homo sapiens]
(801 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33589848 transferrin receptor 2 [Homo sapiens] 1623 0.0
gi|189458819 transferrin receptor [Homo sapiens] 563 e-160
gi|189458817 transferrin receptor [Homo sapiens] 563 e-160
gi|4758398 folate hydrolase 1 isoform 1 [Homo sapiens] 259 9e-69
gi|57232740 N-acetylated alpha-linked acidic dipeptidase-like 1 ... 253 4e-67
gi|4885505 N-acetylated alpha-linked acidic dipeptidase 2 [Homo ... 248 1e-65
gi|62548858 folate hydrolase 1 isoform 2 [Homo sapiens] 242 9e-64
gi|24308545 folate hydrolase 1B [Homo sapiens] 169 1e-41
gi|126157508 N-acetylated alpha-linked acidic dipeptidase 2 [Hom... 149 1e-35
gi|55749804 aminopeptidase Fxna [Homo sapiens] 42 0.002
gi|51873031 nicalin [Homo sapiens] 41 0.005
gi|7706387 plasma glutamate carboxypeptidase [Homo sapiens] 39 0.025
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 33 1.0
gi|118600967 shroom family member 4 [Homo sapiens] 32 1.8
gi|21389589 transmembrane channel-like 4 isoform 2 [Homo sapiens] 32 1.8
gi|223718080 transmembrane channel-like 4 isoform 1 [Homo sapiens] 32 1.8
gi|169215981 PREDICTED: hypothetical protein [Homo sapiens] 32 2.3
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom... 32 2.3
gi|169215786 PREDICTED: hypothetical protein [Homo sapiens] 32 2.3
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom... 32 2.3
gi|169215573 PREDICTED: hypothetical protein [Homo sapiens] 32 2.3
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap... 32 2.3
gi|21704281 junctophilin 2 isoform 1 [Homo sapiens] 32 2.3
gi|37595553 ring finger protein 111 [Homo sapiens] 32 2.3
gi|148536823 type IV alpha 6 collagen isoform A precursor [Homo ... 31 4.0
gi|118197272 ATG2 autophagy related 2 homolog B [Homo sapiens] 31 4.0
gi|55750053 atrophin-1 [Homo sapiens] 31 4.0
gi|55750041 atrophin-1 [Homo sapiens] 31 4.0
gi|16357503 type IV alpha 6 collagen isoform B precursor [Homo s... 31 4.0
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 31 5.2
>gi|33589848 transferrin receptor 2 [Homo sapiens]
Length = 801
Score = 1623 bits (4203), Expect = 0.0
Identities = 801/801 (100%), Positives = 801/801 (100%)
Query: 1 MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPE 60
MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPE
Sbjct: 1 MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPE 60
Query: 61 PLGSRPRQPNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRGSCQACGDSVLVVSE 120
PLGSRPRQPNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRGSCQACGDSVLVVSE
Sbjct: 61 PLGSRPRQPNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRGSCQACGDSVLVVSE 120
Query: 121 DVNYEPDLDFHQGRLYWSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALTQDIR 180
DVNYEPDLDFHQGRLYWSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALTQDIR
Sbjct: 121 DVNYEPDLDFHQGRLYWSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALTQDIR 180
Query: 181 AALSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGN 240
AALSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGN
Sbjct: 181 AALSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGN 240
Query: 241 VTGELVYAHYGRPEDLQDLRARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPE 300
VTGELVYAHYGRPEDLQDLRARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPE
Sbjct: 241 VTGELVYAHYGRPEDLQDLRARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPE 300
Query: 301 PADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPAQPIS 360
PADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPAQPIS
Sbjct: 301 PADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPAQPIS 360
Query: 361 ADIASRLLRKLKGPVAPQEWQGSLLGSPYHLGPGPRLRLVVNNHRTSTPINNIFGCIEGR 420
ADIASRLLRKLKGPVAPQEWQGSLLGSPYHLGPGPRLRLVVNNHRTSTPINNIFGCIEGR
Sbjct: 361 ADIASRLLRKLKGPVAPQEWQGSLLGSPYHLGPGPRLRLVVNNHRTSTPINNIFGCIEGR 420
Query: 421 SEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGD 480
SEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGD
Sbjct: 421 SEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGD 480
Query: 481 FGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPN 540
FGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPN
Sbjct: 481 FGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPN 540
Query: 541 HSGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPFLHTK 600
HSGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPFLHTK
Sbjct: 541 HSGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPFLHTK 600
Query: 601 EDTYENLHKVLQGRLPAVAQAVAQLAGQLLIRLSHDRLLPLDFGRYGDVVLRHIGNLNEF 660
EDTYENLHKVLQGRLPAVAQAVAQLAGQLLIRLSHDRLLPLDFGRYGDVVLRHIGNLNEF
Sbjct: 601 EDTYENLHKVLQGRLPAVAQAVAQLAGQLLIRLSHDRLLPLDFGRYGDVVLRHIGNLNEF 660
Query: 661 SGDLKARGLTLQWVYSARGDYIRAAEKLRQEIYSSEERDERLTRMYNVRIMRVEFYFLSQ 720
SGDLKARGLTLQWVYSARGDYIRAAEKLRQEIYSSEERDERLTRMYNVRIMRVEFYFLSQ
Sbjct: 661 SGDLKARGLTLQWVYSARGDYIRAAEKLRQEIYSSEERDERLTRMYNVRIMRVEFYFLSQ 720
Query: 721 YVSPADSPFRHIFMGRGDHTLGALLDHLRLLRSNSSGTPGATSSTGFQESRFRRQLALLT 780
YVSPADSPFRHIFMGRGDHTLGALLDHLRLLRSNSSGTPGATSSTGFQESRFRRQLALLT
Sbjct: 721 YVSPADSPFRHIFMGRGDHTLGALLDHLRLLRSNSSGTPGATSSTGFQESRFRRQLALLT 780
Query: 781 WTLQGAANALSGDVWNIDNNF 801
WTLQGAANALSGDVWNIDNNF
Sbjct: 781 WTLQGAANALSGDVWNIDNNF 801
>gi|189458819 transferrin receptor [Homo sapiens]
Length = 760
Score = 563 bits (1450), Expect = e-160
Identities = 325/730 (44%), Positives = 443/730 (60%), Gaps = 49/730 (6%)
Query: 84 YLVLTALLIFTGAFLLGYVAF------RGSCQACGDSVLVVSEDVNYEPDLDFHQGR-LY 136
Y + ++ F F++GY+ + + C+ + V E EP DF R LY
Sbjct: 68 YGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVRE----EPGEDFPAARRLY 123
Query: 137 WSDLQAMFLQFLGEGRLEDTIR---QTSLRERVAGSAGMAALTQDIRAALSRQKLDHVWT 193
W DL+ + L TI+ + S R AGS L + KL VW
Sbjct: 124 WDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWR 183
Query: 194 DTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGNVTGELVYAHYGRP 253
D H+V +Q D A N++ VD+ G++ +E+P Y YS VTG+LV+A++G
Sbjct: 184 DQHFVKIQVKDSAQ-NSVIIVDKNGRL--VYLVENPGGYVAYSKAATVTGKLVHANFGTK 240
Query: 254 EDLQDLRARGVDPV-GRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKPS 312
+D +DL PV G +++VR G I+FA+KV NA+ A GVLIY + F P
Sbjct: 241 KDFEDLYT----PVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKF------PI 290
Query: 313 LSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPAQPISADIASRLLRKLK 372
++++ + +GH HLGTGDPYTPGFPSFN TQFPP SSGLP+IP Q IS A +L ++
Sbjct: 291 VNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNME 350
Query: 373 GPVAPQEWQGSLLGSPYHLGPGPRLRLVVNNHRTSTPINNIFGCIEGRSEPDHYVVIGAQ 432
G P +W+ ++L V+N I NIFG I+G EPDHYVV+GAQ
Sbjct: 351 GD-CPSDWKTDSTCRMV-TSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQ 408
Query: 433 RDAWGPGAAKSAVGTAILLELVRTFSSMV-SNGFRPRRSLLFISWDGGDFGSVGSTEWLE 491
RDAWGPGAAKS VGTA+LL+L + FS MV +GF+P RS++F SW GDFGSVG+TEWLE
Sbjct: 409 RDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLE 468
Query: 492 GYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPNHSGQTLYEQVV 551
GYLS LHLKA Y++LD AVLG F SPLL +LIE ++ V P +GQ LY+
Sbjct: 469 GYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPV-TGQFLYQ--- 524
Query: 552 FTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPFLHTKEDTYENLHKVL 611
+ +W A + L +D++A+ F A+ G+PAV F F ED YP+L T DTY+ L + +
Sbjct: 525 --DSNW-ASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTD-YPYLGTTMDTYKELIERI 580
Query: 612 QGRLPAVAQAVAQLAGQLLIRLSHDRLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTL 671
L VA+A A++AGQ +I+L+HD L LD+ RY +L + +LN++ D+K GL+L
Sbjct: 581 P-ELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSL 639
Query: 672 QWVYSARGDYIRAAEKLRQEIYSSEERDERLTRMYNVRIMRVEFYFLSQYVSPADSPFRH 731
QW+YSARGD+ RA +L + ++E+ D + + N R+MRVE++FLS YVSP +SPFRH
Sbjct: 640 QWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRH 699
Query: 732 IFMGRGDHTLGALLDHLRLLRSNSSGTPGATSSTGFQESRFRRQLALLTWTLQGAANALS 791
+F G G HTL ALL++L+L + N+ F E+ FR QLAL TWT+QGAANALS
Sbjct: 700 VFWGSGSHTLPALLENLKLRKQNNG---------AFNETLFRNQLALATWTIQGAANALS 750
Query: 792 GDVWNIDNNF 801
GDVW+IDN F
Sbjct: 751 GDVWDIDNEF 760
>gi|189458817 transferrin receptor [Homo sapiens]
Length = 760
Score = 563 bits (1450), Expect = e-160
Identities = 325/730 (44%), Positives = 443/730 (60%), Gaps = 49/730 (6%)
Query: 84 YLVLTALLIFTGAFLLGYVAF------RGSCQACGDSVLVVSEDVNYEPDLDFHQGR-LY 136
Y + ++ F F++GY+ + + C+ + V E EP DF R LY
Sbjct: 68 YGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVRE----EPGEDFPAARRLY 123
Query: 137 WSDLQAMFLQFLGEGRLEDTIR---QTSLRERVAGSAGMAALTQDIRAALSRQKLDHVWT 193
W DL+ + L TI+ + S R AGS L + KL VW
Sbjct: 124 WDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWR 183
Query: 194 DTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGNVTGELVYAHYGRP 253
D H+V +Q D A N++ VD+ G++ +E+P Y YS VTG+LV+A++G
Sbjct: 184 DQHFVKIQVKDSAQ-NSVIIVDKNGRL--VYLVENPGGYVAYSKAATVTGKLVHANFGTK 240
Query: 254 EDLQDLRARGVDPV-GRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKPS 312
+D +DL PV G +++VR G I+FA+KV NA+ A GVLIY + F P
Sbjct: 241 KDFEDLYT----PVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKF------PI 290
Query: 313 LSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPAQPISADIASRLLRKLK 372
++++ + +GH HLGTGDPYTPGFPSFN TQFPP SSGLP+IP Q IS A +L ++
Sbjct: 291 VNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNME 350
Query: 373 GPVAPQEWQGSLLGSPYHLGPGPRLRLVVNNHRTSTPINNIFGCIEGRSEPDHYVVIGAQ 432
G P +W+ ++L V+N I NIFG I+G EPDHYVV+GAQ
Sbjct: 351 GD-CPSDWKTDSTCRMV-TSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQ 408
Query: 433 RDAWGPGAAKSAVGTAILLELVRTFSSMV-SNGFRPRRSLLFISWDGGDFGSVGSTEWLE 491
RDAWGPGAAKS VGTA+LL+L + FS MV +GF+P RS++F SW GDFGSVG+TEWLE
Sbjct: 409 RDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLE 468
Query: 492 GYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPNHSGQTLYEQVV 551
GYLS LHLKA Y++LD AVLG F SPLL +LIE ++ V P +GQ LY+
Sbjct: 469 GYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPV-TGQFLYQ--- 524
Query: 552 FTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPFLHTKEDTYENLHKVL 611
+ +W A + L +D++A+ F A+ G+PAV F F ED YP+L T DTY+ L + +
Sbjct: 525 --DSNW-ASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTD-YPYLGTTMDTYKELIERI 580
Query: 612 QGRLPAVAQAVAQLAGQLLIRLSHDRLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTL 671
L VA+A A++AGQ +I+L+HD L LD+ RY +L + +LN++ D+K GL+L
Sbjct: 581 P-ELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSL 639
Query: 672 QWVYSARGDYIRAAEKLRQEIYSSEERDERLTRMYNVRIMRVEFYFLSQYVSPADSPFRH 731
QW+YSARGD+ RA +L + ++E+ D + + N R+MRVE++FLS YVSP +SPFRH
Sbjct: 640 QWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRH 699
Query: 732 IFMGRGDHTLGALLDHLRLLRSNSSGTPGATSSTGFQESRFRRQLALLTWTLQGAANALS 791
+F G G HTL ALL++L+L + N+ F E+ FR QLAL TWT+QGAANALS
Sbjct: 700 VFWGSGSHTLPALLENLKLRKQNNG---------AFNETLFRNQLALATWTIQGAANALS 750
Query: 792 GDVWNIDNNF 801
GDVW+IDN F
Sbjct: 751 GDVWDIDNEF 760
>gi|4758398 folate hydrolase 1 isoform 1 [Homo sapiens]
Length = 750
Score = 259 bits (661), Expect = 9e-69
Identities = 208/769 (27%), Positives = 352/769 (45%), Gaps = 84/769 (10%)
Query: 75 AAAGRRAAPYLVLTALLIFTGAFLLGYVAFRGSCQACGDSVLVVSEDVNYEPDLDFHQGR 134
A A R +L AL++ G FLLG++ G + +E N P H +
Sbjct: 11 AVATARRPRWLCAGALVLAGGFFLLGFLF--------GWFIKSSNEATNITPK---HNMK 59
Query: 135 LYWSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALTQDIRAALSRQKLDHVWTD 194
+ +L+A ++ + + +AG+ L + I++ LD V
Sbjct: 60 AFLDELKAE--------NIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELA 111
Query: 195 THYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDP---------DVYCPYSAI---GNVT 242
+ V L +P+ HPN + ++E G L +P D+ P+SA G
Sbjct: 112 HYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPE 171
Query: 243 GELVYAHYGRPEDLQDL-RARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPEP 301
G+LVY +Y R ED L R ++ G++++ R G + KV NAQ GA+GV++Y +P
Sbjct: 172 GDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDP 231
Query: 302 ADFSQDPPKPSLSSQQAVYGHVHLGT-------GDPYTPGFPSFNQTQFPPVASS-GLPS 353
AD+ K G V G GDP TPG+P+ +A + GLPS
Sbjct: 232 ADYFAPGVKSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPS 291
Query: 354 IPAQPISADIASRLLRKLKGPVAPQE-WQGSLLGSPYHLGPG-------PRLRLVVNNHR 405
IP PI A +LL K+ G P W+GSL PY++GPG ++++ +++
Sbjct: 292 IPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLK-VPYNVGPGFTGNFSTQKVKMHIHSTN 350
Query: 406 TSTPINNIFGCIEGRSEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGF 465
T I N+ G + G EPD YV++G RD+W G G A++ E+VR+F ++ G+
Sbjct: 351 EVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGW 410
Query: 466 RPRRSLLFISWDGGDFGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLL 525
RPRR++LF SWD +FG +GSTEW E +L + V Y++ D+++ G+ +PL+
Sbjct: 411 RPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLM 470
Query: 526 TSLIESVLKQVDSPNH--SGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAF---VGV 580
SL+ ++ K++ SP+ G++LYE +PS + + + S F F +G+
Sbjct: 471 YSLVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGI 530
Query: 581 PAVEFSFMEDDQ-----AYPFLHTKEDTYENLHKVLQGRLPAVAQAVAQLAGQLLIRLSH 635
+ + ++ + YP H+ +TYE + K VAQ+ G ++ L++
Sbjct: 531 ASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMF-KYHLTVAQVRGGMVFELAN 589
Query: 636 DRLLPLDFGRYGDVVLRHIGNLNEFS----GDLKARGLTLQWVYSARGDYIRAAEKLRQE 691
+LP D Y V+ ++ + S ++K ++ ++SA ++ A K +
Sbjct: 590 SIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSER 649
Query: 692 IYSSEERDERLTRMYNVRIMRVEFYFLSQYVSPADSPFRHIFMGRGDHTLGALLDHLRLL 751
+ ++ + + RM N ++M +E F+ P +RH+ H A
Sbjct: 650 LQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYA-------- 701
Query: 752 RSNSSGTPGATSSTGFQESR---------FRRQLALLTWTLQGAANALS 791
PG + ES+ +RQ+ + +T+Q AA LS
Sbjct: 702 ---GESFPGIYDALFDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLS 747
>gi|57232740 N-acetylated alpha-linked acidic dipeptidase-like 1
[Homo sapiens]
Length = 740
Score = 253 bits (647), Expect = 4e-67
Identities = 207/692 (29%), Positives = 322/692 (46%), Gaps = 66/692 (9%)
Query: 152 RLEDTIRQTSLRERVAGSAGMAALTQDIRAALSRQK-----LDHVWTDTHYVGLQFPDPA 206
R+ + +R+ S +A S L Q + L R K LD T+ V L FP
Sbjct: 56 RIRENLRELSREPHLASSPRDEDLVQLL---LQRWKDPESGLDSAEASTYEVLLSFPSQE 112
Query: 207 HPNTLHWVDEAGKV------------GEQLPLEDPDVYCPYSAI---GNVTGELVYAHYG 251
PN + V G + GEQ PDV PY+A G G LVYA+ G
Sbjct: 113 QPNVVDIVGPTGGIIHSCHRTEENVTGEQ---GGPDVVQPYAAYAPSGTPQGLLVYANRG 169
Query: 252 RPEDLQDLRARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKP 311
ED ++L+ +G+ G + L R G + K NA G GVL+Y +PAD + P
Sbjct: 170 AEEDFKELQTQGIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSP 229
Query: 312 SLSSQQAVY--------GHVHLGTGDPYTPGFPSFNQTQFPPVAS-SGLPSIPAQPISAD 362
+ + Y G + GDP TP P+ + +A+ SG P IP QPI
Sbjct: 230 DETFPNSWYLPPSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQ 289
Query: 363 IASRLLRKLKGPVAPQEWQGSLLGSPYHLGPGPR----------LRLVVNNHRTSTPINN 412
A LL L G +AP WQG+L G Y LGPG R + + V N +N
Sbjct: 290 DARDLLCNLNGTLAPATWQGAL-GCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSN 348
Query: 413 IFGCIEGRSEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNG-FRPRRSL 471
+ G I G EPD YV+ G RD+W GA + GTA+LLEL R +++ G +RPRRS+
Sbjct: 349 VLGIIRGAVEPDRYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSI 408
Query: 472 LFISWDGGDFGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIES 531
+F SW +FG +GSTE+ E + + L + V Y+++D +V + + +P + S++ S
Sbjct: 409 VFASWGAEEFGLIGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFS 468
Query: 532 VLKQVDSPNHSGQTLYEQ-VVFTNPSWDAEVIRP----LPMDSSAYSFTAFVGVPAVEFS 586
K++ SP ++Y+ + + N S + P L S F F+G+ +++ +
Sbjct: 469 ATKEIRSPGPGDLSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIA 528
Query: 587 FMED-----DQAYPFLHTKEDTYENLHKVLQGRLPAVAQAVAQLAGQLLIRLSHDRLLPL 641
+ D + YP HT DT++ + K L + QAVA+ AG +++RLS LPL
Sbjct: 529 YTYDRSKTSARIYPTYHTAFDTFDYVDKFLDPGFSS-HQAVARTAGSVILRLSDSFFLPL 587
Query: 642 DFGRYGDVVLRHIGNLNEFSGD-LKARGLTLQWVYSARGDYIRAAEKLRQEIYSSEE--R 698
Y + + + + G L+ ++L + +A + A L Q I + ++
Sbjct: 588 KVSDYSETLRSFLQAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSP 647
Query: 699 DERLTRMYNVRIMRVEFYFLSQYVSPADSPFRHIFMGRGDHTLGALLDHLRLLRSNSSGT 758
D RM N ++M +E FL+ P + + H+ G+++ L + S
Sbjct: 648 DPLQVRMLNDQLMLLERTFLNPRAFPEERYYSHVLWA---PRTGSVVTFPGLSNACSRAR 704
Query: 759 PGATSSTGFQESRFRRQLALLTWTLQGAANAL 790
A+ S + E +RQL+++ L+GAA L
Sbjct: 705 DTASGSEAWAE--VQRQLSIVVTALEGAAATL 734
>gi|4885505 N-acetylated alpha-linked acidic dipeptidase 2 [Homo
sapiens]
Length = 740
Score = 248 bits (634), Expect = 1e-65
Identities = 190/681 (27%), Positives = 324/681 (47%), Gaps = 47/681 (6%)
Query: 153 LEDTIRQTSLRERVAGSAGMAALTQDIRAALSRQKLDHVWTDTHYVGLQFPDPAHPNTLH 212
++ +R + +AG+ L + I+ + LD + V L +P+ + N +
Sbjct: 60 IKSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYIS 119
Query: 213 WVDE-AGKVGEQLPLEDPD-----------VYCPYSAIGNVTGELVYAHYGRPEDLQDL- 259
VDE ++ + LE P Y +SA G G+LVY +Y R ED L
Sbjct: 120 IVDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLE 179
Query: 260 RARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKP-----SLS 314
R G++ G++++ R G I KV NA GA G+++Y +PAD+ +P +L
Sbjct: 180 REMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLP 239
Query: 315 SQQAVYGHVHL--GTGDPYTPGFPSFNQTQFPPVASS-GLPSIPAQPISADIASRLLRKL 371
A G+V G GDP TPG+P+ T V G+P IP PI + A LLR L
Sbjct: 240 GTAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLDVEEGVGIPRIPVHPIGYNDAEILLRYL 299
Query: 372 KGPVAPQE-WQGSLLGSPYHLGPG-------PRLRLVVNNHRTSTPINNIFGCIEGRSEP 423
G P + W+G+L S Y +GPG ++R+ V N T I N+ G I G EP
Sbjct: 300 GGIAPPDKSWKGALNVS-YSIGPGFTGSDSFRKVRMHVYNINKITRIYNVVGTIRGSVEP 358
Query: 424 DHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGDFGS 483
D YV++G RD+W GA G A+L E+ R+F ++S G+RPRR+++F SWD +FG
Sbjct: 359 DRYVILGGHRDSWVFGAIDPTSGVAVLQEIARSFGKLMSKGWRPRRTIIFASWDAEEFGL 418
Query: 484 VGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPN--H 541
+GSTEW E + +L +++ Y++ D+++ G+ +PLL L+ + K++ SP+
Sbjct: 419 LGSTEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYKLTKEIPSPDDGF 478
Query: 542 SGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAF---VGVPAVEFSFMEDDQ-----A 593
++LYE + +PS + + + + S F A+ +G+ + + ++ + +
Sbjct: 479 ESKSLYESWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSS 538
Query: 594 YPFLHTKEDTYENLHKVLQGRLPAVAQAVAQLAGQLLIRLSHDRLLPLDFGRYGDVVLRH 653
YP HT +T+E + K +VAQL G L+ L +++P + Y + + +
Sbjct: 539 YPVYHTIYETFELVEKFYDPTFKK-QLSVAQLRGALVYELVDSKIIPFNIQDYAEALKNY 597
Query: 654 IGNLNEFS----GDLKARGLTLQWVYSARGDYIRAAEKLRQEIYSSEERDERLTRMYNVR 709
++ S L G++ ++SA ++ AA + + + + RM N +
Sbjct: 598 AASIYNLSKKHDQQLTDHGVSFDSLFSAVKNFSEAASDFHKRLIQVDLNNPIAVRMMNDQ 657
Query: 710 IMRVEFYFLSQYVSPADSPFRHIFMGRGDHTLGALLDHLRLLRSNSSGTPGATSSTGFQE 769
+M +E F+ P +RHI H A + + A S ++E
Sbjct: 658 LMLLERAFIDPLGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIFDIENKANSRLAWKE 717
Query: 770 SRFRRQLALLTWTLQGAANAL 790
++ +++ +T+Q AA L
Sbjct: 718 --VKKHISIAAFTIQAAAGTL 736
>gi|62548858 folate hydrolase 1 isoform 2 [Homo sapiens]
Length = 719
Score = 242 bits (618), Expect = 9e-64
Identities = 185/661 (27%), Positives = 312/661 (47%), Gaps = 64/661 (9%)
Query: 75 AAAGRRAAPYLVLTALLIFTGAFLLGYVAFRGSCQACGDSVLVVSEDVNYEPDLDFHQGR 134
A A R +L AL++ G FLLG++ G + +E N P H +
Sbjct: 11 AVATARRPRWLCAGALVLAGGFFLLGFLF--------GWFIKSSNEATNITPK---HNMK 59
Query: 135 LYWSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALTQDIRAALSRQKLDHVWTD 194
+ +L+A ++ + + +AG+ L + I++ LD V
Sbjct: 60 AFLDELKAE--------NIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELA 111
Query: 195 THYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDP---------DVYCPYSAI---GNVT 242
+ V L +P+ HPN + ++E G L +P D+ P+SA G
Sbjct: 112 HYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPE 171
Query: 243 GELVYAHYGRPEDLQDL-RARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPEP 301
G+LVY +Y R ED L R ++ G++++ R G + KV NAQ GA+GV++Y +P
Sbjct: 172 GDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDP 231
Query: 302 ADFSQDPPKPSLSSQQAVYGHVHLGT-------GDPYTPGFPSFNQTQFPPVASS-GLPS 353
AD+ K G V G GDP TPG+P+ +A + GLPS
Sbjct: 232 ADYFAPGVKSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPS 291
Query: 354 IPAQPISADIASRLLRKLKGPVAPQE-WQGSLLGSPYHLGPG-------PRLRLVVNNHR 405
IP PI A +LL K+ G P W+GSL PY++GPG ++++ +++
Sbjct: 292 IPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLK-VPYNVGPGFTGNFSTQKVKMHIHSTN 350
Query: 406 TSTPINNIFGCIEGRSEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGF 465
T I N+ G + G EPD YV++G RD+W G G A++ E+VR+F ++ G+
Sbjct: 351 EVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGW 410
Query: 466 RPRRSLLFISWDGGDFGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLL 525
RPRR++LF SWD +FG +GSTEW E +L + V Y++ D+++ G+ +PL+
Sbjct: 411 RPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLM 470
Query: 526 TSLIESVLKQVDSPNH--SGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAF---VGV 580
SL+ ++ K++ SP+ G++LYE +PS + + + S F F +G+
Sbjct: 471 YSLVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGI 530
Query: 581 PAVEFSFMEDDQ-----AYPFLHTKEDTYENLHKVLQGRLPAVAQAVAQLAGQLLIRLSH 635
+ + ++ + YP H+ +TYE + K VAQ+ G ++ L++
Sbjct: 531 ASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMF-KYHLTVAQVRGGMVFELAN 589
Query: 636 DRLLPLDFGRYGDVVLRHIGNLNEFS----GDLKARGLTLQWVYSARGDYIRAAEKLRQE 691
+LP D Y V+ ++ + S ++K ++ ++SA ++ A K +
Sbjct: 590 SIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSER 649
Query: 692 I 692
+
Sbjct: 650 L 650
>gi|24308545 folate hydrolase 1B [Homo sapiens]
Length = 442
Score = 169 bits (427), Expect = 1e-41
Identities = 121/451 (26%), Positives = 215/451 (47%), Gaps = 45/451 (9%)
Query: 373 GPVAPQE--WQGSLLGSPYHLGPG-------PRLRLVVNNHRTSTPINNIFGCIEGRSEP 423
G AP + W+GSL S Y++GPG ++++ +++ T I N+ G + G EP
Sbjct: 2 GGSAPPDSSWRGSLKVS-YNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTLRGAVEP 60
Query: 424 DHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGDFGS 483
D YV++G RD+W G G A++ E VR+F ++ G+RPRR++LF SWD +FG
Sbjct: 61 DRYVILGGHRDSWVFGGIDPQSGAAVVHETVRSFGTLKKEGWRPRRTILFASWDAEEFGL 120
Query: 484 VGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPNH-- 541
+GSTEW E +L + V Y++ D+++ G+ +PL+ SL+ ++ K++ SP+
Sbjct: 121 LGSTEWAEDNSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVYNLTKELKSPDEGF 180
Query: 542 SGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAF---VGVPAVEFSFMEDDQ-----A 593
G++LYE +PS + + + S F F +G+ + + ++ +
Sbjct: 181 EGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSG 240
Query: 594 YPFLHTKEDTYENLHKVLQGRLPAVAQAVAQLAGQLLIRLSHDRLLPLDFGRYGDVVLRH 653
YP H+ +TYE + K VAQ+ G ++ L++ +LP D Y V+ ++
Sbjct: 241 YPLYHSVYETYELVEKFYDPMF-KYHLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKY 299
Query: 654 IGNLNEFS----GDLKARGLTLQWVYSARGDYIRAAEKLRQEIYSSEERDERLTRMYNVR 709
+ S ++K L+ ++SA ++ A K + + ++ + L RM N +
Sbjct: 300 ADKIYNISMKHPQEMKTYSLSFDSLFSAVKNFTEIASKFSERLQDFDKSNPILLRMMNDQ 359
Query: 710 IMRVEFYFLSQYVSPADSPFRHIFMGRGDHTLGALLDHLRLLRSNSSGTPGATSSTGFQE 769
+M +E F+ P +RH+ H A PG + E
Sbjct: 360 LMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYA-----------GESFPGIYDALFDIE 408
Query: 770 SR---------FRRQLALLTWTLQGAANALS 791
S+ +RQ+++ +T+Q AA LS
Sbjct: 409 SKVDPSKAWGDVKRQISVAAFTVQAAAETLS 439
>gi|126157508 N-acetylated alpha-linked acidic dipeptidase 2 [Homo
sapiens]
Length = 795
Score = 149 bits (376), Expect = 1e-35
Identities = 118/442 (26%), Positives = 206/442 (46%), Gaps = 38/442 (8%)
Query: 207 HPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGNVTGELVYAHYGRPEDLQDLRARGVDP 266
HPN +EA K Q L Y YSA G + E++ YG +DL+ +R + +
Sbjct: 241 HPNGQPCSEEARKDSSQDLLYS---YAAYSAKGTLKAEVIDVSYGMADDLKRIR-KIKNV 296
Query: 267 VGRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKPSLSSQQAVYGHVHLG 326
++ L+++G + K+++ + G GVL+Y +P D PK S ++ G
Sbjct: 297 TNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDL----PKTVNPSHDTFMVSLNPG 352
Query: 327 TGDPYTPGFPSFNQTQFPPVASSGLPSIPAQPISADIASRLLRKLKGPVAPQEWQGSLLG 386
GDP TPG+PS +++ + S L S+ QPISA + ++L+ K + L
Sbjct: 353 -GDPSTPGYPSVDESFRQ--SRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLEL- 408
Query: 387 SPYHLGPGPRLRLVVNNHRTSTP---INNIFGCIEGRSEPDHYVVIGAQRD-AWGPGAAK 442
P +R+V +T T + N+ G + G + PD Y+++G+ A +
Sbjct: 409 ------PNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGSHHHTAHSYNGQE 462
Query: 443 SAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGDFGSVGSTEWLEGYLSVLHLKAV 502
A TAI+ +R S V G+RP R+++F SW G FG++GS EW E + VL V
Sbjct: 463 WASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVV 522
Query: 503 VYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPNHSGQTLYEQVVFTNPSWDAEVI 562
Y+SL + + G+ + SP L L V N+ T Q TN I
Sbjct: 523 AYISLHSPIRGNSSLYPVASPSLQQL-------VVEKNNFNCTRRAQCPETN-------I 568
Query: 563 RPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPFLHTKEDTYENLHKVLQGRLPA--VAQ 620
+ + A F +GVP V+F++ + E + ++ P+ + +
Sbjct: 569 SSIQIQGDADYFINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEEMDPSFNLHE 628
Query: 621 AVAQLAGQLLIRLSHDRLLPLD 642
+ +L+G+++++++++ +LP +
Sbjct: 629 TITKLSGEVILQIANEPVLPFN 650
>gi|55749804 aminopeptidase Fxna [Homo sapiens]
Length = 904
Score = 42.4 bits (98), Expect = 0.002
Identities = 43/202 (21%), Positives = 95/202 (47%), Gaps = 25/202 (12%)
Query: 410 INNIFGCIEGRSEPDHYVVIGAQRD--AWGPGAAKSAVGTAILLELVRTFSSMVSNGFRP 467
I N+ +E R H V+ D A PGA+ AV +++LE++R S ++
Sbjct: 183 ITNVVVKLEPRDGAQHAVLANCHFDSVANSPGASDDAVSCSVMLEVLRVLS---TSSEAL 239
Query: 468 RRSLLFISWDGGDFGSVGSTEWLEGYLSVLHLKAVV--YVSLDNAVLGDDKFHAKTSPLL 525
+++F+ ++G + + ++ G+++ +++ +++L+ A +G + +T P
Sbjct: 240 HHAVIFL-FNGAEENVLQAS---HGFITQHPWASLIRAFINLEAAGVGGKELVFQTGPEN 295
Query: 526 TSLIESVLKQVDSPNHSGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEF 585
L+++ V + H ++ Q VF + +P D+ + F +P ++
Sbjct: 296 PWLVQA---YVSAAKHPFASVVAQEVFQSGI--------IPSDTDFRIYRDFGNIPGIDL 344
Query: 586 SFMEDDQAYPFLHTKEDTYENL 607
+F+E+ Y HTK DT + +
Sbjct: 345 AFIENGYIY---HTKYDTADRI 363
>gi|51873031 nicalin [Homo sapiens]
Length = 563
Score = 40.8 bits (94), Expect = 0.005
Identities = 36/125 (28%), Positives = 55/125 (44%), Gaps = 13/125 (10%)
Query: 427 VVIGAQRDAWGP------GAAKSAVGTAILLELVRTFSSMVS-NGFRPRRSLLFISWDGG 479
+VI A DA+G GA + G ++LLEL R FS + + +LLF + GG
Sbjct: 219 IVIVAHYDAFGVAPWLSLGADSNGSGVSVLLELARLFSRLYTYKRTHAAYNLLFFASGGG 278
Query: 480 DFGSVGSTEWLEGYL-----SVLHLKAVVYVSLDNAVLGDD-KFHAKTSPLLTSLIESVL 533
F G+ WLE L S+L + LD G H P +L + L
Sbjct: 279 KFNYQGTKRWLEDNLDHTDSSLLQDNVAFVLCLDTVGRGSSLHLHVSKPPREGTLQHAFL 338
Query: 534 KQVDS 538
+++++
Sbjct: 339 RELET 343
>gi|7706387 plasma glutamate carboxypeptidase [Homo sapiens]
Length = 472
Score = 38.5 bits (88), Expect = 0.025
Identities = 30/129 (23%), Positives = 52/129 (40%), Gaps = 12/129 (9%)
Query: 417 IEGRSEPDHYVVIGAQRDAW--GPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFI 474
I G P+ V++ D+W G GA G I E + + G RP+R+L +
Sbjct: 275 ITGSKYPEQVVLVSGHLDSWDVGQGAMDDGGGAFISWEALSLIKDL---GLRPKRTLRLV 331
Query: 475 SWDGGDFGSVGSTEW-------LEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTS 527
W + G VG+ ++ + Y V+ A ++ G +K A +++
Sbjct: 332 LWTAEEQGGVGAFQYYQLHKVNISNYSLVMESDAGTFLPTGLQFTGSEKARAIMEEVMSL 391
Query: 528 LIESVLKQV 536
L + QV
Sbjct: 392 LQPLNITQV 400
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 33.1 bits (74), Expect = 1.0
Identities = 24/76 (31%), Positives = 35/76 (46%), Gaps = 5/76 (6%)
Query: 97 FLLGYVAFRGSCQACGDSVLVVSEDVNYEPDLDFHQGRLYWSDLQAMFLQ--FLGEGRLE 154
F G FR + LVV V+ D +++ R+YW DL+ LQ FL R E
Sbjct: 50 FSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQE 109
Query: 155 DTIRQTSLRERVAGSA 170
R ++ + V+G A
Sbjct: 110 ---RVCNIEKNVSGMA 122
>gi|118600967 shroom family member 4 [Homo sapiens]
Length = 1493
Score = 32.3 bits (72), Expect = 1.8
Identities = 22/63 (34%), Positives = 27/63 (42%)
Query: 7 LFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPEPLGSRP 66
LF+ AQQ + Q Q E + EEEEE+ EE AE P + E GS
Sbjct: 1114 LFRAAQQQKQQQQQQKQQEEEEEEEEEEEEEEEEEEEEAEEEEEELPPQYFSSETSGSCA 1173
Query: 67 RQP 69
P
Sbjct: 1174 LNP 1176
>gi|21389589 transmembrane channel-like 4 isoform 2 [Homo sapiens]
Length = 706
Score = 32.3 bits (72), Expect = 1.8
Identities = 20/50 (40%), Positives = 23/50 (46%), Gaps = 7/50 (14%)
Query: 32 GHLEEEEEDGEEGAETLAHFCPMELRGPEPLGSRPRQPNLIPWAAAGRRA 81
G LEEEEEDG + EL+ P P SR +PW RRA
Sbjct: 54 GALEEEEEDGGRSRKAFTEVTQTELQDPHP--SRE-----LPWPMQARRA 96
>gi|223718080 transmembrane channel-like 4 isoform 1 [Homo sapiens]
Length = 712
Score = 32.3 bits (72), Expect = 1.8
Identities = 20/50 (40%), Positives = 23/50 (46%), Gaps = 7/50 (14%)
Query: 32 GHLEEEEEDGEEGAETLAHFCPMELRGPEPLGSRPRQPNLIPWAAAGRRA 81
G LEEEEEDG + EL+ P P SR +PW RRA
Sbjct: 60 GALEEEEEDGGRSRKAFTEVTQTELQDPHP--SRE-----LPWPMQARRA 102
>gi|169215981 PREDICTED: hypothetical protein [Homo sapiens]
Length = 299
Score = 32.0 bits (71), Expect = 2.3
Identities = 22/63 (34%), Positives = 33/63 (52%), Gaps = 4/63 (6%)
Query: 334 GFPSFNQTQFPPVASSGLPSIPAQPISADIASRLLRKLKGPVAPQEWQGSLLGSPYHL-G 392
G P+ N T P + ++G+PSIP+Q + + K +GP+ E QG+ G L
Sbjct: 98 GAPAAN-TSLPTMLATGIPSIPSQALGTQCSP--AGKGEGPIVIPEEQGAWRGEGSWLKT 154
Query: 393 PGP 395
PGP
Sbjct: 155 PGP 157
>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
sapiens]
Length = 1188
Score = 32.0 bits (71), Expect = 2.3
Identities = 47/189 (24%), Positives = 70/189 (37%), Gaps = 34/189 (17%)
Query: 297 IYPEPADFSQD--PPKPSL-------SSQQAVYGHV----HLGTGDPYTPGFPSFNQTQF 343
+ P P +FS D PP P+L S + Y + + G G P GF F
Sbjct: 985 VIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRF----- 1039
Query: 344 PPVASSGLPSIPAQPISADIASRLLRKL------KGPVAPQEWQGSLLGSPYHLGP---G 394
P + + + S S + ++L +GP P G L SP GP G
Sbjct: 1040 -PAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGG 1098
Query: 395 PRLRLVVNNHRT-----STPINNIFGCIEGRSEPDHYVVIGAQRDAWGPGAAKSAVGTAI 449
P +R V + R P ++ G G +E H G+ + P A +S T
Sbjct: 1099 PEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAP-GSADYGFAPAAGRSPYTTTR 1157
Query: 450 LLELVRTFS 458
+ TF+
Sbjct: 1158 YGSPINTFT 1166
>gi|169215786 PREDICTED: hypothetical protein [Homo sapiens]
Length = 299
Score = 32.0 bits (71), Expect = 2.3
Identities = 22/63 (34%), Positives = 33/63 (52%), Gaps = 4/63 (6%)
Query: 334 GFPSFNQTQFPPVASSGLPSIPAQPISADIASRLLRKLKGPVAPQEWQGSLLGSPYHL-G 392
G P+ N T P + ++G+PSIP+Q + + K +GP+ E QG+ G L
Sbjct: 98 GAPAAN-TSLPTMLATGIPSIPSQALGTQCSP--AGKGEGPIVIPEEQGAWRGEGSWLKT 154
Query: 393 PGP 395
PGP
Sbjct: 155 PGP 157
>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
sapiens]
Length = 1188
Score = 32.0 bits (71), Expect = 2.3
Identities = 47/189 (24%), Positives = 70/189 (37%), Gaps = 34/189 (17%)
Query: 297 IYPEPADFSQD--PPKPSL-------SSQQAVYGHV----HLGTGDPYTPGFPSFNQTQF 343
+ P P +FS D PP P+L S + Y + + G G P GF F
Sbjct: 985 VIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRF----- 1039
Query: 344 PPVASSGLPSIPAQPISADIASRLLRKL------KGPVAPQEWQGSLLGSPYHLGP---G 394
P + + + S S + ++L +GP P G L SP GP G
Sbjct: 1040 -PAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGG 1098
Query: 395 PRLRLVVNNHRT-----STPINNIFGCIEGRSEPDHYVVIGAQRDAWGPGAAKSAVGTAI 449
P +R V + R P ++ G G +E H G+ + P A +S T
Sbjct: 1099 PEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAP-GSADYGFAPAAGRSPYTTTR 1157
Query: 450 LLELVRTFS 458
+ TF+
Sbjct: 1158 YGSPINTFT 1166
>gi|169215573 PREDICTED: hypothetical protein [Homo sapiens]
Length = 299
Score = 32.0 bits (71), Expect = 2.3
Identities = 22/63 (34%), Positives = 33/63 (52%), Gaps = 4/63 (6%)
Query: 334 GFPSFNQTQFPPVASSGLPSIPAQPISADIASRLLRKLKGPVAPQEWQGSLLGSPYHL-G 392
G P+ N T P + ++G+PSIP+Q + + K +GP+ E QG+ G L
Sbjct: 98 GAPAAN-TSLPTMLATGIPSIPSQALGTQCSP--AGKGEGPIVIPEEQGAWRGEGSWLKT 154
Query: 393 PGP 395
PGP
Sbjct: 155 PGP 157
>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sapiens]
Length = 1188
Score = 32.0 bits (71), Expect = 2.3
Identities = 47/189 (24%), Positives = 70/189 (37%), Gaps = 34/189 (17%)
Query: 297 IYPEPADFSQD--PPKPSL-------SSQQAVYGHV----HLGTGDPYTPGFPSFNQTQF 343
+ P P +FS D PP P+L S + Y + + G G P GF F
Sbjct: 985 VIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRF----- 1039
Query: 344 PPVASSGLPSIPAQPISADIASRLLRKL------KGPVAPQEWQGSLLGSPYHLGP---G 394
P + + + S S + ++L +GP P G L SP GP G
Sbjct: 1040 -PAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGG 1098
Query: 395 PRLRLVVNNHRT-----STPINNIFGCIEGRSEPDHYVVIGAQRDAWGPGAAKSAVGTAI 449
P +R V + R P ++ G G +E H G+ + P A +S T
Sbjct: 1099 PEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAP-GSADYGFAPAAGRSPYTTTR 1157
Query: 450 LLELVRTFS 458
+ TF+
Sbjct: 1158 YGSPINTFT 1166
>gi|21704281 junctophilin 2 isoform 1 [Homo sapiens]
Length = 696
Score = 32.0 bits (71), Expect = 2.3
Identities = 28/93 (30%), Positives = 36/93 (38%), Gaps = 5/93 (5%)
Query: 306 QDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPAQPISADIAS 365
Q PP PS + A+Y H P P F P V SG S P+ P +A + +
Sbjct: 549 QAPPAPSREPEVALYQGYHSYAVRTTPPEPPPFEDQPEPEV--SGSESAPSSPATAPLQA 606
Query: 366 RLLRKLKGPVAPQEWQGSLLGSPYHLGPGPRLR 398
LR GP +E L P PR +
Sbjct: 607 PTLR---GPEPARETPAKLEPKPIIPKAEPRAK 636
>gi|37595553 ring finger protein 111 [Homo sapiens]
Length = 986
Score = 32.0 bits (71), Expect = 2.3
Identities = 32/122 (26%), Positives = 50/122 (40%), Gaps = 16/122 (13%)
Query: 281 AQKVTNAQDFGAQGVLIYPEPADFSQDPPKPSLSS----QQAVYGHV-----HLGTGDPY 331
+Q +++ +G+ ++ P+P Q PP+PSLSS Y + H + P+
Sbjct: 612 SQPLSSIDGYGSS-MVAQPQP----QPPPQPSLSSCRHYMPPPYASLTRPLHHQASACPH 666
Query: 332 TPGFPSFNQTQFPPVASSGLPSIPAQPISADIASRLLRKLKGPVAPQEWQGSLLGSPYHL 391
+ G P QTQ PP +P P + I+S P P + P HL
Sbjct: 667 SHGNPP-PQTQPPPQVDYVIPH-PVHAFHSQISSHATSHPVAPPPPTHLASTAAPIPQHL 724
Query: 392 GP 393
P
Sbjct: 725 PP 726
>gi|148536823 type IV alpha 6 collagen isoform A precursor [Homo
sapiens]
Length = 1691
Score = 31.2 bits (69), Expect = 4.0
Identities = 24/74 (32%), Positives = 28/74 (37%), Gaps = 18/74 (24%)
Query: 299 PEPADFSQDPPKPSLSSQQAVYGHVHLG-----------TGDPYTPGFPSFNQTQFPPVA 347
P P D K L QQ + G + +G P TPGFP P
Sbjct: 627 PGPRGLPGDKGKDGLPGQQGLPGSKGITLPCIIPGSYGPSGFPGTPGFPG-------PKG 679
Query: 348 SSGLPSIPAQPISA 361
S GLP P QP S+
Sbjct: 680 SRGLPGTPGQPGSS 693
>gi|118197272 ATG2 autophagy related 2 homolog B [Homo sapiens]
Length = 2078
Score = 31.2 bits (69), Expect = 4.0
Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 7/57 (12%)
Query: 13 QLSPRSSQTVYQRV----EGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPEPLGSR 65
+++P + ++ +R+ E GH +EEEE GA +L C + P P SR
Sbjct: 851 KINPPAMHSILERIAAEEEEENDGHYQEEEEG---GAHSLKDVCDLRRPAPSPFSSR 904
>gi|55750053 atrophin-1 [Homo sapiens]
Length = 1190
Score = 31.2 bits (69), Expect = 4.0
Identities = 15/38 (39%), Positives = 18/38 (47%), Gaps = 5/38 (13%)
Query: 326 GTGDP-----YTPGFPSFNQTQFPPVASSGLPSIPAQP 358
GT P + PG P+ PP SGLPS+P P
Sbjct: 675 GTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPP 712
>gi|55750041 atrophin-1 [Homo sapiens]
Length = 1190
Score = 31.2 bits (69), Expect = 4.0
Identities = 15/38 (39%), Positives = 18/38 (47%), Gaps = 5/38 (13%)
Query: 326 GTGDP-----YTPGFPSFNQTQFPPVASSGLPSIPAQP 358
GT P + PG P+ PP SGLPS+P P
Sbjct: 675 GTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPP 712
>gi|16357503 type IV alpha 6 collagen isoform B precursor [Homo
sapiens]
Length = 1690
Score = 31.2 bits (69), Expect = 4.0
Identities = 24/74 (32%), Positives = 28/74 (37%), Gaps = 18/74 (24%)
Query: 299 PEPADFSQDPPKPSLSSQQAVYGHVHLG-----------TGDPYTPGFPSFNQTQFPPVA 347
P P D K L QQ + G + +G P TPGFP P
Sbjct: 626 PGPRGLPGDKGKDGLPGQQGLPGSKGITLPCIIPGSYGPSGFPGTPGFPG-------PKG 678
Query: 348 SSGLPSIPAQPISA 361
S GLP P QP S+
Sbjct: 679 SRGLPGTPGQPGSS 692
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 30.8 bits (68), Expect = 5.2
Identities = 25/113 (22%), Positives = 50/113 (44%), Gaps = 6/113 (5%)
Query: 449 ILLELVRTFSSMVSNGFRPRRSLLFIS---WDGGDFGSVGSTEWLEGYLSVLHLKAVVYV 505
+ L+ +RTF S F +RS LF + +D DFG V T + + + ++
Sbjct: 70 LCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPF 129
Query: 506 SLDNAVLGDDKFHAKTSPLLTSLI---ESVLKQVDSPNHSGQTLYEQVVFTNP 555
+ +GD+ ++ S + + E + V++ G +YE ++ + P
Sbjct: 130 PTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEP 182
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,606,089
Number of Sequences: 37866
Number of extensions: 1625665
Number of successful extensions: 5148
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 5061
Number of HSP's gapped (non-prelim): 56
length of query: 801
length of database: 18,247,518
effective HSP length: 110
effective length of query: 691
effective length of database: 14,082,258
effective search space: 9730840278
effective search space used: 9730840278
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.