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Search of human proteins with 33469933
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
(1194 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 2395 0.0
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 2314 0.0
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 820 0.0
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 820 0.0
gi|11386139 phospholipase C beta 3 [Homo sapiens] 740 0.0
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 689 0.0
gi|19115964 phospholipase C delta 3 [Homo sapiens] 362 1e-99
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 360 4e-99
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 360 6e-99
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 360 6e-99
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 348 1e-95
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 336 9e-92
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 336 9e-92
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 330 6e-90
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 330 6e-90
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 330 6e-90
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 328 1e-89
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 328 1e-89
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 298 2e-80
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 204 5e-52
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 174 3e-43
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 174 3e-43
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 173 1e-42
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 64 7e-10
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 59 2e-08
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 58 5e-08
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 57 1e-07
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 57 1e-07
gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens] 55 4e-07
gi|21735548 centrosomal protein 2 [Homo sapiens] 54 7e-07
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 2395 bits (6206), Expect = 0.0
Identities = 1194/1194 (100%), Positives = 1194/1194 (100%)
Query: 1 MAKPYEFNWQKEVPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL 60
MAKPYEFNWQKEVPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
Sbjct: 1 MAKPYEFNWQKEVPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL 60
Query: 61 ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE 120
ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
Sbjct: 61 ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE 120
Query: 121 VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK 180
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
Sbjct: 121 VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK 180
Query: 181 VIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD 240
VIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
Sbjct: 181 VIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD 240
Query: 241 QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE 300
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
Sbjct: 241 QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE 300
Query: 301 NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD 360
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
Sbjct: 301 NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD 360
Query: 361 CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM 420
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
Sbjct: 361 CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM 420
Query: 421 SKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM 480
SKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
Sbjct: 421 SKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM 480
Query: 481 MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLV 540
MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLV
Sbjct: 481 MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLV 540
Query: 541 TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG 600
TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG
Sbjct: 541 TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG 600
Query: 601 LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL 660
LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL
Sbjct: 601 LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL 660
Query: 661 NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT 720
NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT
Sbjct: 661 NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT 720
Query: 721 YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK 780
YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK
Sbjct: 721 YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK 780
Query: 781 LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK 840
LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK
Sbjct: 781 LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK 840
Query: 841 FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAA 900
FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAA
Sbjct: 841 FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAA 900
Query: 901 LASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ 960
LASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ
Sbjct: 901 LASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ 960
Query: 961 VDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQH 1020
VDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQH
Sbjct: 961 VDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQH 1020
Query: 1021 TKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQ 1080
TKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQ
Sbjct: 1021 TKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQ 1080
Query: 1081 AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ 1140
AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ
Sbjct: 1081 AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ 1140
Query: 1141 LEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQNAN 1194
LEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQNAN
Sbjct: 1141 LEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQNAN 1194
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 2314 bits (5996), Expect = 0.0
Identities = 1153/1153 (100%), Positives = 1153/1153 (100%)
Query: 1 MAKPYEFNWQKEVPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL 60
MAKPYEFNWQKEVPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
Sbjct: 1 MAKPYEFNWQKEVPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL 60
Query: 61 ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE 120
ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
Sbjct: 61 ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE 120
Query: 121 VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK 180
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
Sbjct: 121 VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK 180
Query: 181 VIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD 240
VIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
Sbjct: 181 VIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD 240
Query: 241 QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE 300
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
Sbjct: 241 QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE 300
Query: 301 NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD 360
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
Sbjct: 301 NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD 360
Query: 361 CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM 420
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
Sbjct: 361 CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM 420
Query: 421 SKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM 480
SKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
Sbjct: 421 SKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM 480
Query: 481 MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLV 540
MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLV
Sbjct: 481 MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLV 540
Query: 541 TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG 600
TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG
Sbjct: 541 TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG 600
Query: 601 LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL 660
LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL
Sbjct: 601 LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL 660
Query: 661 NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT 720
NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT
Sbjct: 661 NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT 720
Query: 721 YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK 780
YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK
Sbjct: 721 YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK 780
Query: 781 LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK 840
LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK
Sbjct: 781 LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK 840
Query: 841 FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAA 900
FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAA
Sbjct: 841 FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAA 900
Query: 901 LASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ 960
LASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ
Sbjct: 901 LASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ 960
Query: 961 VDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQH 1020
VDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQH
Sbjct: 961 VDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQH 1020
Query: 1021 TKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQ 1080
TKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQ
Sbjct: 1021 TKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQ 1080
Query: 1081 AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ 1140
AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ
Sbjct: 1081 AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ 1140
Query: 1141 LEHLEFLEKQNEQ 1153
LEHLEFLEKQNEQ
Sbjct: 1141 LEHLEFLEKQNEQ 1153
>gi|33356544 phosphoinositide-specific phospholipase C beta 1 isoform
b [Homo sapiens]
Length = 1173
Score = 820 bits (2119), Expect = 0.0
Identities = 474/1184 (40%), Positives = 692/1184 (58%), Gaps = 84/1184 (7%)
Query: 13 VPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGA 72
V L++GT F +++++S + P + + D GFF W + KE ++L+ SL+ R G
Sbjct: 18 VSDSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGR 76
Query: 73 ---IPKDPKILAALEA--VGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVE 127
PKDPK+ L+ +G+ LE R++ V G DLVNIS +VA EV K+W
Sbjct: 77 HAKAPKDPKLRELLDVGNIGR----LEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTN 132
Query: 128 GLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALK 187
+ S+ N A N+S L+K + KL G+IP+++I R F++ + K + AL+
Sbjct: 133 EVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADR--KRVETALE 190
Query: 188 ELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLN 247
LPS +ND I F+ E + +CPR +I+++F + YLTVDQ++ F+N
Sbjct: 191 ACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFIN 250
Query: 248 EHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLD 307
QRDPRLNEIL+P ++ +IE YEP+ L +KG IS DGF RYL +EN V +
Sbjct: 251 LKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPE 310
Query: 308 RLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGE 367
+L+L ++M PL+HYFI+SSHNTYLT Q G SSVEMYRQVLL+GCRCVELDCW G+
Sbjct: 311 KLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTA 370
Query: 368 DQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHC-SKYQQYKMSKYCED 426
++EP+ITHG M T+I FK+VI+AI E AF TS +P++LSFENH S QQ KM++YC
Sbjct: 371 EEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRL 430
Query: 427 LFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGES 486
+FGD LL + LE +PLE G LPSP DL KIL+KNK+ ++ E
Sbjct: 431 IFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKK--------------KSHKSSEG 476
Query: 487 ASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQ 546
+ + E + +S+ E + P + S DD + +S+ +G
Sbjct: 477 SGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTA------ 530
Query: 547 AWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKT 606
G+ +S ++NY QPVKF+ F ++++RN + MSSF E+ GL L
Sbjct: 531 ---------GSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTK 581
Query: 607 HAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFE 666
+EFV YNK Q+SRIYPKG RVDSSNYMPQ+FWNAGCQMV+LN+QT DLAMQ+N G +E
Sbjct: 582 SPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYE 641
Query: 667 YNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDM 726
YNG GY LKP+FMRRPD+ FDPF+E VDG++A T SV++ISGQFLSDKK+GTYVEVDM
Sbjct: 642 YNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDM 701
Query: 727 YGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRI 786
+GLP DT RK F+T+ N +NPV+ EE VF+KV+LP LA LRIAVY++ K IG RI
Sbjct: 702 FGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRI 761
Query: 787 LPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITE 846
LP+ ++ GY +I LRNE N+PL+LP +F I +K YVPD + D+++ALS+P +++++ E
Sbjct: 762 LPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLME 821
Query: 847 KRADQMRAMGIE-------TSDIADVPSDTSKNDKKGKANTA---KANVTPQSSSELRPT 896
+RA Q+ A+ +E +D + PS+ + A +TP+ S+ +
Sbjct: 822 QRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHS 881
Query: 897 TTAALASGVEAKKGIELIPQV-------RIEDLKQMKAYLKHLKKQQKELNSLKKKHAKE 949
A + AK +LI V IE+LKQ K+++K KK KE+ L K+H K+
Sbjct: 882 QPAPGSVKAPAKTE-DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKK 940
Query: 950 HSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKG-------GSNCLEMKKETEIKI 1002
+ + K H T+ ++I Y + ++ EK +K KKK GS+ +E
Sbjct: 941 TTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIE--------- 991
Query: 1003 QTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQT 1062
Q L + ++++ K+ +++N + + L++KL A E Q
Sbjct: 992 QDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQN 1051
Query: 1063 QQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEER 1122
QLK + KE + + K+ + + I++ KS K+K++ E E+ S ++ ++
Sbjct: 1052 NQLKKLKEICEKEKKELKKKMDKKRQEKITEAKS-KDKSQMEEEKTEMIRSYIQEVVQYI 1110
Query: 1123 KRLAMKQSKEMDQL----KKVQLEHLEFLEK---QNEQLLKSCH 1159
KRL QSK ++L K+++ + L+ K + L ++CH
Sbjct: 1111 KRLEEAQSKRQEKLVEKHKEIRQQILDEKPKGEGSSSFLSETCH 1154
>gi|12083581 phosphoinositide-specific phospholipase C beta 1 isoform
a [Homo sapiens]
Length = 1216
Score = 820 bits (2117), Expect = 0.0
Identities = 468/1154 (40%), Positives = 678/1154 (58%), Gaps = 77/1154 (6%)
Query: 13 VPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGA 72
V L++GT F +++++S + P + + D GFF W + KE ++L+ SL+ R G
Sbjct: 18 VSDSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGR 76
Query: 73 ---IPKDPKILAALEA--VGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVE 127
PKDPK+ L+ +G+ LE R++ V G DLVNIS +VA EV K+W
Sbjct: 77 HAKAPKDPKLRELLDVGNIGR----LEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTN 132
Query: 128 GLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALK 187
+ S+ N A N+S L+K + KL G+IP+++I R F++ + K + AL+
Sbjct: 133 EVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADR--KRVETALE 190
Query: 188 ELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLN 247
LPS +ND I F+ E + +CPR +I+++F + YLTVDQ++ F+N
Sbjct: 191 ACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFIN 250
Query: 248 EHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLD 307
QRDPRLNEIL+P ++ +IE YEP+ L +KG IS DGF RYL +EN V +
Sbjct: 251 LKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPE 310
Query: 308 RLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGE 367
+L+L ++M PL+HYFI+SSHNTYLT Q G SSVEMYRQVLL+GCRCVELDCW G+
Sbjct: 311 KLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTA 370
Query: 368 DQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHC-SKYQQYKMSKYCED 426
++EP+ITHG M T+I FK+VI+AI E AF TS +P++LSFENH S QQ KM++YC
Sbjct: 371 EEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRL 430
Query: 427 LFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGES 486
+FGD LL + LE +PLE G LPSP DL KIL+KNK+ ++ E
Sbjct: 431 IFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKK--------------KSHKSSEG 476
Query: 487 ASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQ 546
+ + E + +S+ E + P + S DD + +S+ +G
Sbjct: 477 SGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTA------ 530
Query: 547 AWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKT 606
G+ +S ++NY QPVKF+ F ++++RN + MSSF E+ GL L
Sbjct: 531 ---------GSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTK 581
Query: 607 HAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFE 666
+EFV YNK Q+SRIYPKG RVDSSNYMPQ+FWNAGCQMV+LN+QT DLAMQ+N G +E
Sbjct: 582 SPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYE 641
Query: 667 YNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDM 726
YNG GY LKP+FMRRPD+ FDPF+E VDG++A T SV++ISGQFLSDKK+GTYVEVDM
Sbjct: 642 YNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDM 701
Query: 727 YGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRI 786
+GLP DT RK F+T+ N +NPV+ EE VF+KV+LP LA LRIAVY++ K IG RI
Sbjct: 702 FGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRI 761
Query: 787 LPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITE 846
LP+ ++ GY +I LRNE N+PL+LP +F I +K YVPD + D+++ALS+P +++++ E
Sbjct: 762 LPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLME 821
Query: 847 KRADQMRAMGIE-------TSDIADVPSDTSKNDKKGKANTA---KANVTPQSSSELRPT 896
+RA Q+ A+ +E +D + PS+ + A +TP+ S+ +
Sbjct: 822 QRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHS 881
Query: 897 TTAALASGVEAKKGIELIPQV-------RIEDLKQMKAYLKHLKKQQKELNSLKKKHAKE 949
A + AK +LI V IE+LKQ K+++K KK KE+ L K+H K+
Sbjct: 882 QPAPGSVKAPAKTE-DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKK 940
Query: 950 HSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKG-------GSNCLEMKKETEIKI 1002
+ + K H T+ ++I Y + ++ EK +K KKK GS+ +E
Sbjct: 941 TTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIE--------- 991
Query: 1003 QTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQT 1062
Q L + ++++ K+ +++N + + L++KL A E Q
Sbjct: 992 QDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQN 1051
Query: 1063 QQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEER 1122
QLK + KE + + K+ + + I++ KS K+K++ E E+ S ++ ++
Sbjct: 1052 NQLKKLKEICEKEKKELKKKMDKKRQEKITEAKS-KDKSQMEEEKTEMIRSYIQEVVQYI 1110
Query: 1123 KRLAMKQSKEMDQL 1136
KRL QSK ++L
Sbjct: 1111 KRLEEAQSKRQEKL 1124
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 740 bits (1911), Expect = 0.0
Identities = 458/1204 (38%), Positives = 675/1204 (56%), Gaps = 68/1204 (5%)
Query: 2 AKPYEFNWQKEVPSF---LQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQ 58
A+P Q E P+ L+ G+ F +++EE+ L +VD GFFL W E
Sbjct: 4 AQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTL-RVDPNGFFLYWTGPNMEVD 62
Query: 59 VLECSLINSIRSGA---IPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMV 115
L+ S I R+G +PKDPKI L G + LE +++ V SG D VN F +
Sbjct: 63 TLDISSIRDTRTGRYARLPKDPKIREVL-GFGGPDARLEEKLMTVVSGPDPVNTVFLNFM 121
Query: 116 AENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFAS 175
A + K W E L + N A N S T L+K + KL N +G+IPV++I + F++
Sbjct: 122 AVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSA 181
Query: 176 GKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTD 235
K K + AL+ GL +++ I P FS E F K+C R DI+ + +I
Sbjct: 182 DK--KRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKP 239
Query: 236 YLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRY 295
YLT++QL+ F+N+ QRDPRLNE+L+P +A +IE YEP++ ++ +S +GF RY
Sbjct: 240 YLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRY 299
Query: 296 LMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCR 355
L +EN + L+ L+L +M PL+ YFI+SSHNTYLT Q G SSVEMYRQ LL GCR
Sbjct: 300 LGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCR 359
Query: 356 CVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHC-SK 414
CVELD W G+ ++EP ITHG M T++ +DV++AI ETAF TS YPVILSFENH S
Sbjct: 360 CVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSA 419
Query: 415 YQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNK-RLKPEV---- 469
QQ KM++YC +FGD LL + L+ +PL PG LPSP DL +IL+KNK R +P
Sbjct: 420 KQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPD 479
Query: 470 ---EKKQLE----ALRSMMEAGESASPANILEDDNEEEIESADQEEEA---HPEFKFGNE 519
K+ LE AL A E +SP L + + EE P +
Sbjct: 480 SAGRKRPLEQSNSALSESSAATEPSSPQ--LGSPSSDSCPGLSNGEEVGLEKPSLEPQKS 537
Query: 520 LSADDLGHKEAVANSVKKGLVTVEDEQAWMASYKY-------VGATTNIHPYLSTMINYA 572
L + L V + ++E+ K + N +ST++NY
Sbjct: 538 LGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYI 597
Query: 573 QPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSS 632
+PVKF+ F A +RN + MSSF E+ + L +EFV YNK+Q+SRIYPKG RVDSS
Sbjct: 598 EPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSS 657
Query: 633 NYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSE 692
NYMPQ+FWN GCQ+V+LN+QT D+AMQLN G FEYNG GYLLKP+FMRRPD++FDPF+E
Sbjct: 658 NYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTE 717
Query: 693 TPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVY 752
VDG++A V+VISGQFLSD+K+G YVEVDM+GLP DT R+++RTR N NPV+
Sbjct: 718 VIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDT-RRKYRTRTSQGNSFNPVW 776
Query: 753 NEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLP 812
+EE F F KV+LP LA LRIA +++ K +G RILP+ +++GY ++ LRNE N+PL LP
Sbjct: 777 DEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLP 836
Query: 813 TIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAM-GIETSDIADVPSDTSK 871
+ Y+PD D +AL +P K +S+ ++RA Q+ A+ G + ++
Sbjct: 837 ALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQ 896
Query: 872 NDKKGKANTAKANVTPQSSSELR---PTTTAALASGVEAKKGIELIPQV-------RIED 921
+ + G ++ +P +S R PTT+ A S + +LI + +++
Sbjct: 897 SQQLGSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDE 956
Query: 922 LKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEK 981
L+ KA +K +Q+++L L+KKH ++ T+ + ++ +AQ E ++
Sbjct: 957 LRGHKALVKLRSRQERDLRELRKKHQRKAVTLTR----RLLDGLAQAQAEGRC--RLRPG 1010
Query: 982 AMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDL 1041
A+ GG+ +E KE E D + +E + + E+ E + R
Sbjct: 1011 AL---GGAADVEDTKEGE--------DEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLE 1059
Query: 1042 HLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKA 1101
HL Q + L++++++A+ Q ++LK ++RE KE+ Q + + +IS+ K +++K
Sbjct: 1060 HLRQALQRLREVVLDANTTQFKRLKEMNEREKKEL---QKILDRKRHNSISEAK-MRDKH 1115
Query: 1102 ERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAV 1161
++E + E+N + + + +RL Q + D+L Q + L+ L ++ +LL
Sbjct: 1116 KKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQE 1175
Query: 1162 SQTQ 1165
Q Q
Sbjct: 1176 CQEQ 1179
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 689 bits (1779), Expect = 0.0
Identities = 413/1175 (35%), Positives = 648/1175 (55%), Gaps = 63/1175 (5%)
Query: 12 EVPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSG 71
+V ++L +G F ++++E+ V P + +VD G++L W + KE + L+ + I R G
Sbjct: 12 KVKAYLSQGERFIKWDDETTVASP-VILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFG 70
Query: 72 AIPKDPKILAALEAVGKS--ENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGL 129
K PK + +N + + V SG D+V+++F V+ V K W E +
Sbjct: 71 KFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDV 130
Query: 130 RSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKEL 189
+++ + N S T L K +KL N+ GKIPV++ + F + + K + AL
Sbjct: 131 LALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADR--KRVEAALSAC 188
Query: 190 GLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEH 249
LP GKND I P F + +CPR +I+++F + Y+T + L F+N+
Sbjct: 189 HLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQK 248
Query: 250 QRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRL 309
QRD RLN +LFP + +I+ YEP ++G +S +G +L EN+ + D+L
Sbjct: 249 QRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKL 308
Query: 310 ELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQ 369
L+ +M PL HYFI+SSHNTYLT QF G SS EMYRQVLL+GCRCVELDCW GK D+
Sbjct: 309 LLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDE 368
Query: 370 EPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHC-SKYQQYKMSKYCEDLF 428
EPIITHG M TDI FK+ I+AI E+AF TS YP+ILSFENH S QQ KM++YC +F
Sbjct: 369 EPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIF 428
Query: 429 GDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESAS 488
GD+LL + LE PL+PG LPSP DL+ KILIKNK K Q +G ++S
Sbjct: 429 GDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNK-------KNQF--------SGPTSS 473
Query: 489 PANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQAW 548
+ + SA E + G EL +++ +E + G + E+ +
Sbjct: 474 SKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEE----EEESGNLDEEEIKKM 529
Query: 549 MASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHA 608
+ G + +S+++NY QP KF F + ++N Y +SSF E L +
Sbjct: 530 QSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKAS 589
Query: 609 IEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYN 668
++FV+YNKRQMSRIYPKG R+DSSNYMPQ+FWNAGCQMV+LN+QT DL MQ N FE+N
Sbjct: 590 VQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFN 649
Query: 669 GSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYG 728
G GYLLK +FMRRPD+ F+PFS +D V+A T S+ VISGQFLS++ + TYVEV+++G
Sbjct: 650 GQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFG 709
Query: 729 LPTDTIRKEFRTRM-VMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRIL 787
LP D ++ +RT++ N +NPV+ EE FVF K+++P+LA LR+AV ++ NK +G RI+
Sbjct: 710 LPGDP-KRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRII 768
Query: 788 PLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEK 847
P++ L +GY H+ L +E N PL++P +F + +K Y+P + D+ AL++P KF S +
Sbjct: 769 PINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDT 828
Query: 848 RADQMR-AMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAALASGV- 905
++ +++ AMG +P K + V Q + L PT+ + A+
Sbjct: 829 KSVKLKEAMG-------GLPE---------KPFPLASPVASQVNGALAPTSNGSPAARAG 872
Query: 906 ---EAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVD 962
EA K +E+L+++K +K ++ +KEL L+++ A+ + + Q+
Sbjct: 873 AREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLA 932
Query: 963 KIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTK 1022
++ + K +KK L ++ +V+E+ K
Sbjct: 933 ELGPPGVGGVGACKLGPGKGSRKK---RSLPREESAGAAPGEGPEGVDGRVREL-----K 984
Query: 1023 EWSEMINTHSAEEQ-----EIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMR 1077
+ E+ EEQ + ++ H+++Q + +L + + LK + + ++KEM+
Sbjct: 985 DRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMK 1044
Query: 1078 AHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLK 1137
+E + ++ K +K +ER RE+N+S+ ++ ++ K++ + ++L+
Sbjct: 1045 KKLETKRLERIQGMT--KVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLE 1102
Query: 1138 KVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAAD 1172
+ Q LE + + +Q K A + + +G A+
Sbjct: 1103 EKQAACLEQIREMEKQFQKEALAEYEARMKGLEAE 1137
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 362 bits (929), Expect = 1e-99
Identities = 247/723 (34%), Positives = 363/723 (50%), Gaps = 108/723 (14%)
Query: 114 MVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFM---TNTNGKIP---VR 167
+ A E ++WV GL + R + +S L HW+ +N + K+ ++
Sbjct: 152 LAAPTAEEAQRWVRGLTKL--RARLDAMSQRERLD-HWIHSYLHRADSNQDSKMSFKEIK 208
Query: 168 SITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFK 227
S+ R + + KE ND +E E +++ R ++E++F
Sbjct: 209 SLLRMVNVDMNDMYAYLLFKECD--HSNNDRLEGAEIE-----EFLRRLLKRPELEEIFH 261
Query: 228 KINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLI 287
+ +G+ L+ +L+ FL + + RA Q+I+ YE +E K+ L+
Sbjct: 262 QYSGEDR-VLSAPELLEFLEDQGEEGAT---------LARAQQLIQTYELNETAKQHELM 311
Query: 288 SSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYR 347
+ DGF YL+S E A + ++Q+M+ PLAHYFISSSHNTYLT Q GG SS E Y
Sbjct: 312 TLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYV 371
Query: 348 QVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILS 407
+ GCRCVELDCW+G G EP+I HG + + ILF+DV+QA+++ AF S YPVILS
Sbjct: 372 RAFAQGCRCVELDCWEGPG--GEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILS 429
Query: 408 FENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKP 467
ENHC QQ M+++ + GD+L+ QAL+S E LPSP LK ++L+K K+
Sbjct: 430 LENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPE---ELPSPEQLKGRVLVKGKK--- 483
Query: 468 EVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGH 527
L A RS E G + S E+D+EEE ++E EA + + ++S
Sbjct: 484 ------LPAARS--EDGRALSDREEEEEDDEEE----EEEVEAAAQRRLAKQIS------ 525
Query: 528 KEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERN 587
P LS + Y + + H A
Sbjct: 526 -----------------------------------PELSALAVYCHATRLRTLHPAPNAP 550
Query: 588 IHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMV 647
+SS +E ++ FV +N RQ++R+YP G R++S+NY PQ WN+GCQ+V
Sbjct: 551 QPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLV 610
Query: 648 SLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQV 707
+LN+QTP M LN G+F NG CGY+LKP +R+PD TFDP E P G T S+QV
Sbjct: 611 ALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDP--EYP--GPPRTTLSIQV 666
Query: 708 ISGQFLSDKK-------IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEE-SFVF 759
++ Q L + V ++++G+P D R+E T V+NNG NP + + F
Sbjct: 667 LTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQE--TDYVLNNGFNPRWGQTLQFQL 724
Query: 760 RKVILPDLAVLRIAVYD----DNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815
R P+LA++R V D N +GQ LPL L+ GYRHI L ++ LS T+F
Sbjct: 725 R---APELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLF 781
Query: 816 CNI 818
I
Sbjct: 782 IQI 784
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 360 bits (924), Expect = 4e-99
Identities = 238/626 (38%), Positives = 335/626 (53%), Gaps = 75/626 (11%)
Query: 207 EKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAK 266
E+F + + + R ++++LF+ + D LT+ + + FL E Q++ L
Sbjct: 193 EEFVQFYKALTKRAEVQELFESFSADGQK-LTLLEFLDFLQEEQKERDCTSEL------- 244
Query: 267 RAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISS 326
A+++I+ YEP + K + ++S DGF YL S + L +YQ+M PL HYFI S
Sbjct: 245 -ALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICS 303
Query: 327 SHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFK 386
SHNTYL G Q G+SSVE Y + L GCRCVE+D WDG EP++ HG + + ILFK
Sbjct: 304 SHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSG--EPVVYHGHTLTSRILFK 361
Query: 387 DVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGR 446
DV+ + + AF TS+YPVILS E HCS QQ M+++ ++ G+ LL L+ + P +
Sbjct: 362 DVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDG--VLPTQ 419
Query: 447 ALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQ 506
LPSP +L+RKIL+K K+L LE+D E E
Sbjct: 420 -LPSPEELRRKILVKGKKLT--------------------------LEEDLEYE------ 446
Query: 507 EEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLS 566
EEEA PE + +EL+ + E EQ K + + P LS
Sbjct: 447 EEEAEPELE-ESELALESQFETEPEPQ-----------EQNLQNKDKKKKSKPILCPALS 494
Query: 567 TMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKG 626
+++ Y + V F+ F ++E Y +SSF+E+ +K EFV +N Q+SR+YP G
Sbjct: 495 SLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSG 554
Query: 627 GRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRT 686
R DSSNY PQ WNAGCQMV++N QT L M + G F NG CGY+LKPDF+R +
Sbjct: 555 LRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSS 614
Query: 687 FDPFSETPVDGVIAATCSVQVISGQFLS--DKK-----IGTYVEVDMYGLPTDTIRKEFR 739
F P E P+ A T +QVISGQ L DK + V+V ++G+ DT R+E
Sbjct: 615 FHP--EKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQE-- 670
Query: 740 TRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYD----DNNKLIGQRILPLDGLQAG 795
T V NNG NP Y ++ FR V++P+LA+LR V D N IGQ LP +Q G
Sbjct: 671 TNYVENNGFNP-YWGQTLCFR-VLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQG 728
Query: 796 YRHISLRNEGNKPLSLPTIFCNIVLK 821
YRHI L ++ L +IF I ++
Sbjct: 729 YRHIHLLSKDGISLRPASIFVYICIQ 754
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 360 bits (923), Expect = 6e-99
Identities = 246/732 (33%), Positives = 363/732 (49%), Gaps = 110/732 (15%)
Query: 114 MVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTF 173
++A +P + WV GL IIH+ + + +HW + S R
Sbjct: 110 LIAPSPADAQHWVLGLHKIIHHSGSMDQRQKL---QHW--------------IHSCLRKA 152
Query: 174 ASGKTEKVIFQAL----KELGLPSGKN---------DEIEPTAFSYEKFYELTQKICPRT 220
K K+ F+ L KEL + + D + + E+ + + R
Sbjct: 153 DKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRV 212
Query: 221 DIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDED 280
+I+ F + G + L+VDQLV+FL QR+ L A+ +IE YEP E
Sbjct: 213 EIDRTFAEAAGSG-ETLSVDQLVTFLQHQQREEAAGPAL--------ALSLIERYEPSET 263
Query: 281 LKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGK 340
K + ++ DGF YL+S + + L +YQ+M PL+HY +SSSHNTYL Q G
Sbjct: 264 AKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGP 323
Query: 341 SSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTS 400
SS E Y + L GCRC+ELDCWD G +QEPII HG + ILF DV++AI++ AF S
Sbjct: 324 SSTEAYIRALCKGCRCLELDCWD--GPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKAS 381
Query: 401 EYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILI 460
YPVILS ENHC+ QQ M+++ + G +LL + L+ +LPSP LK KIL+
Sbjct: 382 PYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDG----VTNSLPSPEQLKGKILL 437
Query: 461 KNKRLKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNEL 520
K K+L + GE A ++ D++ E+A+ E+EA
Sbjct: 438 KGKKLG-----------GLLPPGGEGGPEATVVSDED----EAAEMEDEA---------- 472
Query: 521 SADDLGHKEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGF 580
+ V + K+ + + E LS M+ Y + V F GF
Sbjct: 473 ------VRSRVQHKPKEDKLRLAQE-------------------LSDMVIYCKSVHFGGF 507
Query: 581 -HVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIF 639
Y M+SF+E+ L L+ FV +N +SRIYP G R DSSNY P
Sbjct: 508 SSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEM 567
Query: 640 WNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVI 699
WN GCQ+V+LN+QTP M + QG+F+ NG+CGY+LKP F+R P+ TF+P +
Sbjct: 568 WNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWA 627
Query: 700 AATCSVQVISGQFL------SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYN 753
+++VISGQ L + + V V+++G+ D ++ T ++ NNG NP ++
Sbjct: 628 RKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQ--TAVITNNGFNPWWD 685
Query: 754 EESFVFRKVILPDLAVLRIAVYD----DNNKLIGQRILPLDGLQAGYRHISLRNEGNKPL 809
E F F +V++PDLA++R V D N IGQ +PL+ L+ GYRH+ L ++
Sbjct: 686 TE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQH 743
Query: 810 SLPTIFCNIVLK 821
T+F I L+
Sbjct: 744 PSATLFVKISLQ 755
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 360 bits (923), Expect = 6e-99
Identities = 246/732 (33%), Positives = 363/732 (49%), Gaps = 110/732 (15%)
Query: 114 MVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTF 173
++A +P + WV GL IIH+ + + +HW + S R
Sbjct: 131 LIAPSPADAQHWVLGLHKIIHHSGSMDQRQKL---QHW--------------IHSCLRKA 173
Query: 174 ASGKTEKVIFQAL----KELGLPSGKN---------DEIEPTAFSYEKFYELTQKICPRT 220
K K+ F+ L KEL + + D + + E+ + + R
Sbjct: 174 DKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRV 233
Query: 221 DIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDED 280
+I+ F + G + L+VDQLV+FL QR+ L A+ +IE YEP E
Sbjct: 234 EIDRTFAEAAGSG-ETLSVDQLVTFLQHQQREEAAGPAL--------ALSLIERYEPSET 284
Query: 281 LKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGK 340
K + ++ DGF YL+S + + L +YQ+M PL+HY +SSSHNTYL Q G
Sbjct: 285 AKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGP 344
Query: 341 SSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTS 400
SS E Y + L GCRC+ELDCWD G +QEPII HG + ILF DV++AI++ AF S
Sbjct: 345 SSTEAYIRALCKGCRCLELDCWD--GPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKAS 402
Query: 401 EYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILI 460
YPVILS ENHC+ QQ M+++ + G +LL + L+ +LPSP LK KIL+
Sbjct: 403 PYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDG----VTNSLPSPEQLKGKILL 458
Query: 461 KNKRLKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNEL 520
K K+L + GE A ++ D++ E+A+ E+EA
Sbjct: 459 KGKKLG-----------GLLPPGGEGGPEATVVSDED----EAAEMEDEA---------- 493
Query: 521 SADDLGHKEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGF 580
+ V + K+ + + E LS M+ Y + V F GF
Sbjct: 494 ------VRSRVQHKPKEDKLRLAQE-------------------LSDMVIYCKSVHFGGF 528
Query: 581 -HVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIF 639
Y M+SF+E+ L L+ FV +N +SRIYP G R DSSNY P
Sbjct: 529 SSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEM 588
Query: 640 WNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVI 699
WN GCQ+V+LN+QTP M + QG+F+ NG+CGY+LKP F+R P+ TF+P +
Sbjct: 589 WNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWA 648
Query: 700 AATCSVQVISGQFL------SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYN 753
+++VISGQ L + + V V+++G+ D ++ T ++ NNG NP ++
Sbjct: 649 RKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQ--TAVITNNGFNPWWD 706
Query: 754 EESFVFRKVILPDLAVLRIAVYD----DNNKLIGQRILPLDGLQAGYRHISLRNEGNKPL 809
E F F +V++PDLA++R V D N IGQ +PL+ L+ GYRH+ L ++
Sbjct: 707 TE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQH 764
Query: 810 SLPTIFCNIVLK 821
T+F I L+
Sbjct: 765 PSATLFVKISLQ 776
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 348 bits (894), Expect = 1e-95
Identities = 249/768 (32%), Positives = 378/768 (49%), Gaps = 97/768 (12%)
Query: 114 MVAENPEVTKQWVEGLRSIIHNFR-ANNVSPMTCLKKHWMKLAFMT---NTNGKIPVRSI 169
+V+ + EV + WV GLR ++ ++++ + W+K F N +G + + +
Sbjct: 135 LVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEV 194
Query: 170 TRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKI 229
+ + Q +K++ + +D +E+F + + R D+ L
Sbjct: 195 LQLLHKLNVN-LPRQRVKQMFREADTDDH--QGTLGFEEFCAFYKMMSTRRDLYLLMLTY 251
Query: 230 NGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISS 289
+ K D+L L FL Q+ + + IIE +EP + K KGL+
Sbjct: 252 SNHK-DHLDAASLQRFLQVEQKMAGVT--------LESCQDIIEQFEPCPENKSKGLLGI 302
Query: 290 DGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQV 349
DGF Y S + ++Q+M PL+HYFI+SSHNTYL G Q +S V+MY V
Sbjct: 303 DGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWV 362
Query: 350 LLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFE 409
L AGCRCVE+DCWDG D EPI+ HG + + ILFKDVI+ I + AF+ +EYPVILS E
Sbjct: 363 LQAGCRCVEVDCWDGP--DGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIE 420
Query: 410 NHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEV 469
NHCS QQ KM++Y D+ GD K L S E LPSP LK KIL+K K+L +
Sbjct: 421 NHCSVIQQKKMAQYLTDILGD---KLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANI 477
Query: 470 EKKQLEALRSMMEA------------GESASPANILEDDNEEEIESADQEEEAH------ 511
+ E S ++ G++++ +E+ + +++S +E +
Sbjct: 478 SEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPN 537
Query: 512 --------PEFKFGNELSADD---------------------------LGHKEAVANSVK 536
P K G + A++ G K A SV+
Sbjct: 538 NFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVE 597
Query: 537 KGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFN 596
+G + T + LS ++ Y + V + E + +SSF+
Sbjct: 598 EGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEM--EAASSWQVSSFS 655
Query: 597 ESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDL 656
E+ L+ +++ +N++Q+SRIYP RVDSSNY PQ FWNAGCQMV+LNYQ+
Sbjct: 656 ETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGR 715
Query: 657 AMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDK 716
+QLN+ KF NG CGY+LKP M + F+P SE P+ G + +++ISGQ L
Sbjct: 716 MLQLNRAKFSANGGCGYVLKPGCMCQ--GVFNPNSEDPLPGQLKKQLVLRIISGQQLPKP 773
Query: 717 K----------IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPD 766
+ I +VEV++ GLP D R++ TR+V +NG NP + EE+ VF V +P+
Sbjct: 774 RDSMLGDRGEIIDPFVEVEIIGLPVDCSREQ--TRVVDDNGFNPTW-EETLVF-MVHMPE 829
Query: 767 LAVLRIAVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSL 811
+A++R V+D + IGQR L + GYRH+ L EG + S+
Sbjct: 830 IALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYL--EGMEEASI 875
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 336 bits (861), Expect = 9e-92
Identities = 259/829 (31%), Positives = 400/829 (48%), Gaps = 120/829 (14%)
Query: 19 EGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSL--INSIRSGAIPKD 76
EG+ + S ++ L D L W K+ + + + I +R+G
Sbjct: 145 EGSELKKVRSNSRIYHRYFLLDADMQS--LRWEPSKKDSEKAKIDIKSIKEVRTG----- 197
Query: 77 PKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIH-- 134
K + G S+ E V G + ++ +VA + +V WV GLR +I
Sbjct: 198 -KNTDIFRSNGISDQISEDCAFSVIYGENYESLD---LVANSADVANIWVTGLRYLISYG 253
Query: 135 ------------NFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVI 182
N R + VS M + L +T N +R++ + K E
Sbjct: 254 KHTLDMLESSQDNMRTSWVSQMFS-EIDVDNLGHITLCNAVQCIRNLNPGLKTSKIEL-- 310
Query: 183 FQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQL 242
KEL K+ + T + E+F E+ ++C R +I L + + +K ++L L
Sbjct: 311 --KFKELH----KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK-EFLDTKDL 363
Query: 243 VSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENA 302
+ FL Q +NE + +++II YEP ++ ++KG +S DGF YLMS +
Sbjct: 364 MMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCY 415
Query: 303 PVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCW 362
+ ++ Q+M PL+HYFI+SSHNTYL QF G S + Y + L GCR VELD W
Sbjct: 416 IFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVW 475
Query: 363 DGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSK 422
D G D EP+I G M + I+F+ VI I + AF SEYP+IL ENHCS QQ M +
Sbjct: 476 D--GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQ 533
Query: 423 YCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMME 482
+ + L GD L + P LPSP+ LK KILIK K+L
Sbjct: 534 HMKKLLGDKL----YTTSPNVEESYLPSPDVLKGKILIKAKKL----------------- 572
Query: 483 AGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTV 542
+S + +E D +E E A+ + + G E N + V V
Sbjct: 573 ----SSNCSGVEGDVTDEDEGAEMSQ------RMGKE-------------NMEQPNNVPV 609
Query: 543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLG 602
+ Q + LS +++ + V+F+ F V+ + ++ + SFNE +
Sbjct: 610 KRFQ--------------LCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASK 655
Query: 603 YLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQ 662
Y + +FVNYNKR ++R++P R+DSSN PQ FW GCQ+V++N+QTP L M LN
Sbjct: 656 YANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNI 715
Query: 663 GKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKK----- 717
G F NG+CGY+L+P MR F ++ V GV +++ISGQ K
Sbjct: 716 GWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAK 775
Query: 718 ---IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAV 774
+ YV V+++G+P D E RT+ V NG P++ +ESF F ++ LP+LA++R V
Sbjct: 776 GDVVDPYVYVEIHGIPADC--AEQRTKTVHQNGDAPIF-DESFEF-QINLPELAMVRFVV 831
Query: 775 YDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVL 820
DD+ ++ IGQ +P + LQ GYRH+ L++ + L+ ++F ++ +
Sbjct: 832 LDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 336 bits (861), Expect = 9e-92
Identities = 259/829 (31%), Positives = 400/829 (48%), Gaps = 120/829 (14%)
Query: 19 EGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSL--INSIRSGAIPKD 76
EG+ + S ++ L D L W K+ + + + I +R+G
Sbjct: 19 EGSELKKVRSNSRIYHRYFLLDADMQS--LRWEPSKKDSEKAKIDIKSIKEVRTG----- 71
Query: 77 PKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIH-- 134
K + G S+ E V G + ++ +VA + +V WV GLR +I
Sbjct: 72 -KNTDIFRSNGISDQISEDCAFSVIYGENYESLD---LVANSADVANIWVTGLRYLISYG 127
Query: 135 ------------NFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVI 182
N R + VS M + L +T N +R++ + K E
Sbjct: 128 KHTLDMLESSQDNMRTSWVSQMFS-EIDVDNLGHITLCNAVQCIRNLNPGLKTSKIEL-- 184
Query: 183 FQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQL 242
KEL K+ + T + E+F E+ ++C R +I L + + +K ++L L
Sbjct: 185 --KFKELH----KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK-EFLDTKDL 237
Query: 243 VSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENA 302
+ FL Q +NE + +++II YEP ++ ++KG +S DGF YLMS +
Sbjct: 238 MMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCY 289
Query: 303 PVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCW 362
+ ++ Q+M PL+HYFI+SSHNTYL QF G S + Y + L GCR VELD W
Sbjct: 290 IFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVW 349
Query: 363 DGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSK 422
D G D EP+I G M + I+F+ VI I + AF SEYP+IL ENHCS QQ M +
Sbjct: 350 D--GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQ 407
Query: 423 YCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMME 482
+ + L GD L + P LPSP+ LK KILIK K+L
Sbjct: 408 HMKKLLGDKL----YTTSPNVEESYLPSPDVLKGKILIKAKKL----------------- 446
Query: 483 AGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTV 542
+S + +E D +E E A+ + + G E N + V V
Sbjct: 447 ----SSNCSGVEGDVTDEDEGAEMSQ------RMGKE-------------NMEQPNNVPV 483
Query: 543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLG 602
+ Q + LS +++ + V+F+ F V+ + ++ + SFNE +
Sbjct: 484 KRFQ--------------LCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASK 529
Query: 603 YLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQ 662
Y + +FVNYNKR ++R++P R+DSSN PQ FW GCQ+V++N+QTP L M LN
Sbjct: 530 YANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNI 589
Query: 663 GKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKK----- 717
G F NG+CGY+L+P MR F ++ V GV +++ISGQ K
Sbjct: 590 GWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAK 649
Query: 718 ---IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAV 774
+ YV V+++G+P D E RT+ V NG P++ +ESF F ++ LP+LA++R V
Sbjct: 650 GDVVDPYVYVEIHGIPADC--AEQRTKTVHQNGDAPIF-DESFEF-QINLPELAMVRFVV 705
Query: 775 YDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVL 820
DD+ ++ IGQ +P + LQ GYRH+ L++ + L+ ++F ++ +
Sbjct: 706 LDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 754
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 330 bits (845), Expect = 6e-90
Identities = 247/785 (31%), Positives = 387/785 (49%), Gaps = 115/785 (14%)
Query: 114 MVAENPEVTKQWVEGLRSIIHNFR-ANNVSPMTCLKKHWMKLAFMT---NTNGKIPVRSI 169
++ NPE + W+ GL+ ++ ++++ W+K F N +G + + I
Sbjct: 108 LITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEI 167
Query: 170 TRTFAS---GKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLF 226
+ + + Q +E DE + T ++E+F + + R D+ L
Sbjct: 168 HQLMHKLNVNLPRRKVRQMFQE-----ADTDENQGT-LTFEEFCVFYKMMSLRRDLYLLL 221
Query: 227 KKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGL 286
+ DK D+LTV++L FL Q+ +N + + + II+ +E E+ K K +
Sbjct: 222 LSYS-DKKDHLTVEELAQFLKVEQK---MNNVTTDY-----CLDIIKKFEVSEENKVKNV 272
Query: 287 ISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMY 346
+ +GF ++ S E+YQ+MD PL +Y+I+SSHNTYLTG Q +S V+MY
Sbjct: 273 LGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMY 332
Query: 347 RQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVIL 406
+VL GCRCVE+DCWDG D EP++ HG + + ILF+DV++ I + AFV +E+PVIL
Sbjct: 333 ARVLQEGCRCVEVDCWDGP--DGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVIL 390
Query: 407 SFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLK 466
S ENHCS QQ K+++Y + +FGD K L S + LPSP LK KIL+K K+L
Sbjct: 391 SIENHCSIQQQRKIAQYLKGIFGD---KLDLSSVDTGECKQLPSPQSLKGKILVKGKKLP 447
Query: 467 ------------------PEVE----------------------KKQLEALRSMMEAGES 486
E+E +K+LE+L + +
Sbjct: 448 YHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDK 507
Query: 487 ASPANIL---------EDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKK 537
P + E N +S D +E G L + HK+ S K
Sbjct: 508 EDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH--GRSLMTNFGKHKKTT-KSRSK 564
Query: 538 GLVTVEDEQAWMASYKYVGA---------TTNIHPYLSTMINYAQPVKFQGFHVAEERNI 588
T ++E ++ K G T + LS ++ Y V Q +
Sbjct: 565 SYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGT 621
Query: 589 HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS 648
N+ SF+E+ ++ + +F+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+V+
Sbjct: 622 TGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVA 681
Query: 649 LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI 708
LNYQ+ MQLN+ KF+ NG+CGY+LKP M + TF+PFS P+ ++VI
Sbjct: 682 LNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVI 739
Query: 709 SGQFL----------SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFV 758
SGQ L + I +VEV++ GLP D + + TR+V +NG NPV+ EE+
Sbjct: 740 SGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ--TRVVDDNGFNPVW-EETLT 796
Query: 759 FRKVILPDLAVLRIAVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815
F V +P++A++R V+D + +GQR + L GYRH+ L L+ +IF
Sbjct: 797 F-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIF 850
Query: 816 CNIVL 820
+I +
Sbjct: 851 VHITI 855
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 330 bits (845), Expect = 6e-90
Identities = 247/785 (31%), Positives = 387/785 (49%), Gaps = 115/785 (14%)
Query: 114 MVAENPEVTKQWVEGLRSIIHNFR-ANNVSPMTCLKKHWMKLAFMT---NTNGKIPVRSI 169
++ NPE + W+ GL+ ++ ++++ W+K F N +G + + I
Sbjct: 108 LITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEI 167
Query: 170 TRTFAS---GKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLF 226
+ + + Q +E DE + T ++E+F + + R D+ L
Sbjct: 168 HQLMHKLNVNLPRRKVRQMFQE-----ADTDENQGT-LTFEEFCVFYKMMSLRRDLYLLL 221
Query: 227 KKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGL 286
+ DK D+LTV++L FL Q+ +N + + + II+ +E E+ K K +
Sbjct: 222 LSYS-DKKDHLTVEELAQFLKVEQK---MNNVTTDY-----CLDIIKKFEVSEENKVKNV 272
Query: 287 ISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMY 346
+ +GF ++ S E+YQ+MD PL +Y+I+SSHNTYLTG Q +S V+MY
Sbjct: 273 LGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMY 332
Query: 347 RQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVIL 406
+VL GCRCVE+DCWDG D EP++ HG + + ILF+DV++ I + AFV +E+PVIL
Sbjct: 333 ARVLQEGCRCVEVDCWDGP--DGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVIL 390
Query: 407 SFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLK 466
S ENHCS QQ K+++Y + +FGD K L S + LPSP LK KIL+K K+L
Sbjct: 391 SIENHCSIQQQRKIAQYLKGIFGD---KLDLSSVDTGECKQLPSPQSLKGKILVKGKKLP 447
Query: 467 ------------------PEVE----------------------KKQLEALRSMMEAGES 486
E+E +K+LE+L + +
Sbjct: 448 YHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDK 507
Query: 487 ASPANIL---------EDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKK 537
P + E N +S D +E G L + HK+ S K
Sbjct: 508 EDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH--GRSLMTNFGKHKKTT-KSRSK 564
Query: 538 GLVTVEDEQAWMASYKYVGA---------TTNIHPYLSTMINYAQPVKFQGFHVAEERNI 588
T ++E ++ K G T + LS ++ Y V Q +
Sbjct: 565 SYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGT 621
Query: 589 HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS 648
N+ SF+E+ ++ + +F+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+V+
Sbjct: 622 TGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVA 681
Query: 649 LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI 708
LNYQ+ MQLN+ KF+ NG+CGY+LKP M + TF+PFS P+ ++VI
Sbjct: 682 LNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVI 739
Query: 709 SGQFL----------SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFV 758
SGQ L + I +VEV++ GLP D + + TR+V +NG NPV+ EE+
Sbjct: 740 SGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ--TRVVDDNGFNPVW-EETLT 796
Query: 759 FRKVILPDLAVLRIAVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815
F V +P++A++R V+D + +GQR + L GYRH+ L L+ +IF
Sbjct: 797 F-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIF 850
Query: 816 CNIVL 820
+I +
Sbjct: 851 VHITI 855
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 330 bits (845), Expect = 6e-90
Identities = 247/785 (31%), Positives = 387/785 (49%), Gaps = 115/785 (14%)
Query: 114 MVAENPEVTKQWVEGLRSIIHNFR-ANNVSPMTCLKKHWMKLAFMT---NTNGKIPVRSI 169
++ NPE + W+ GL+ ++ ++++ W+K F N +G + + I
Sbjct: 90 LITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEI 149
Query: 170 TRTFAS---GKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLF 226
+ + + Q +E DE + T ++E+F + + R D+ L
Sbjct: 150 HQLMHKLNVNLPRRKVRQMFQE-----ADTDENQGT-LTFEEFCVFYKMMSLRRDLYLLL 203
Query: 227 KKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGL 286
+ DK D+LTV++L FL Q+ +N + + + II+ +E E+ K K +
Sbjct: 204 LSYS-DKKDHLTVEELAQFLKVEQK---MNNVTTDY-----CLDIIKKFEVSEENKVKNV 254
Query: 287 ISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMY 346
+ +GF ++ S E+YQ+MD PL +Y+I+SSHNTYLTG Q +S V+MY
Sbjct: 255 LGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMY 314
Query: 347 RQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVIL 406
+VL GCRCVE+DCWDG D EP++ HG + + ILF+DV++ I + AFV +E+PVIL
Sbjct: 315 ARVLQEGCRCVEVDCWDGP--DGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVIL 372
Query: 407 SFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLK 466
S ENHCS QQ K+++Y + +FGD K L S + LPSP LK KIL+K K+L
Sbjct: 373 SIENHCSIQQQRKIAQYLKGIFGD---KLDLSSVDTGECKQLPSPQSLKGKILVKGKKLP 429
Query: 467 ------------------PEVE----------------------KKQLEALRSMMEAGES 486
E+E +K+LE+L + +
Sbjct: 430 YHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDK 489
Query: 487 ASPANIL---------EDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKK 537
P + E N +S D +E G L + HK+ S K
Sbjct: 490 EDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH--GRSLMTNFGKHKKTT-KSRSK 546
Query: 538 GLVTVEDEQAWMASYKYVGA---------TTNIHPYLSTMINYAQPVKFQGFHVAEERNI 588
T ++E ++ K G T + LS ++ Y V Q +
Sbjct: 547 SYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGT 603
Query: 589 HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS 648
N+ SF+E+ ++ + +F+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+V+
Sbjct: 604 TGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVA 663
Query: 649 LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI 708
LNYQ+ MQLN+ KF+ NG+CGY+LKP M + TF+PFS P+ ++VI
Sbjct: 664 LNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVI 721
Query: 709 SGQFL----------SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFV 758
SGQ L + I +VEV++ GLP D + + TR+V +NG NPV+ EE+
Sbjct: 722 SGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ--TRVVDDNGFNPVW-EETLT 778
Query: 759 FRKVILPDLAVLRIAVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815
F V +P++A++R V+D + +GQR + L GYRH+ L L+ +IF
Sbjct: 779 F-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIF 832
Query: 816 CNIVL 820
+I +
Sbjct: 833 VHITI 837
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 328 bits (842), Expect = 1e-89
Identities = 251/831 (30%), Positives = 397/831 (47%), Gaps = 121/831 (14%)
Query: 15 SFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGK--EGQVLECSLINSIRSGA 72
SF+Q G + S ++ N F +D L W K E L+ S I IR G
Sbjct: 113 SFMQAGCELKKVRPNSRIY--NRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLG- 169
Query: 73 IPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSI 132
K G ++ E + G + ++ +VA + +V WV GLR +
Sbjct: 170 -----KNTETFRNNGLADQICEDCAFSILHGENYESLD---LVANSADVANIWVSGLRYL 221
Query: 133 IHNFRANNVSPMTCLKKH-------WMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQA 185
+ + + P+ ++ + W+K F + I S + K +
Sbjct: 222 V----SRSKQPLDFMEGNQNTPRFMWLKTVFEA---ADVDGNGIMLEDTSVELIKQLNPT 274
Query: 186 LKELGL-----PSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD 240
LKE + K+ E T + E+F E ++C R ++ L +I+ +K +YL +
Sbjct: 275 LKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNK-EYLDAN 333
Query: 241 QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE 300
L+ FL Q + E + + II YE E+ ++KG ++ DGF +YL+S E
Sbjct: 334 DLMLFLEAEQGVTHITEDI--------CLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSE 385
Query: 301 NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD 360
++ ++ Q+M PL+HY+I++SHNTYL QF G + + Y + L GCR VELD
Sbjct: 386 CDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELD 445
Query: 361 CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM 420
D G D EPI+ + M T + F+ VI+ I + AFV SEYP+IL NHCS QQ M
Sbjct: 446 VSD--GSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVM 503
Query: 421 SKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM 480
++ + +FG+ L +A PL LPSP LKR I++K K+L
Sbjct: 504 AQQMKKVFGNKLYTEA----PLPSESYLPSPEKLKRMIIVKGKKL--------------- 544
Query: 481 MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLV 540
S ++LE E D++EEA + +S D G ++ +
Sbjct: 545 ------PSDPDVLEG------EVTDEDEEA----EMSRRMSVDYNGEQKQI--------- 579
Query: 541 TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG 600
+ LS +++ + V+++ F ++ + ++ M SF+E+
Sbjct: 580 -------------------RLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEA 620
Query: 601 LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL 660
+ +FVNYNK+ +SRIYP R+DSSN PQ FWN GCQ+V++N+QTP M L
Sbjct: 621 SRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDL 680
Query: 661 NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKK--- 717
+ G F NG CGY+L+P MR F ++ + GV +++ISGQ K
Sbjct: 681 HTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGAC 740
Query: 718 -----IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRI 772
I YV ++++G+P D E RT+ V N NP++ +E+F F +V LP+LA++R
Sbjct: 741 AKGDVIDPYVCIEIHGIPADC--SEQRTKTVQQNSDNPIF-DETFEF-QVNLPELAMIRF 796
Query: 773 AVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVL 820
V DD+ ++ IGQ +P + LQ GYRH+ LR+ + T+F +I +
Sbjct: 797 VVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 847
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 328 bits (842), Expect = 1e-89
Identities = 251/831 (30%), Positives = 397/831 (47%), Gaps = 121/831 (14%)
Query: 15 SFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGK--EGQVLECSLINSIRSGA 72
SF+Q G + S ++ N F +D L W K E L+ S I IR G
Sbjct: 15 SFMQAGCELKKVRPNSRIY--NRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLG- 71
Query: 73 IPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSI 132
K G ++ E + G + ++ +VA + +V WV GLR +
Sbjct: 72 -----KNTETFRNNGLADQICEDCAFSILHGENYESLD---LVANSADVANIWVSGLRYL 123
Query: 133 IHNFRANNVSPMTCLKKH-------WMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQA 185
+ + + P+ ++ + W+K F + I S + K +
Sbjct: 124 V----SRSKQPLDFMEGNQNTPRFMWLKTVFEA---ADVDGNGIMLEDTSVELIKQLNPT 176
Query: 186 LKELGL-----PSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD 240
LKE + K+ E T + E+F E ++C R ++ L +I+ +K +YL +
Sbjct: 177 LKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNK-EYLDAN 235
Query: 241 QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE 300
L+ FL Q + E + + II YE E+ ++KG ++ DGF +YL+S E
Sbjct: 236 DLMLFLEAEQGVTHITEDI--------CLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSE 287
Query: 301 NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD 360
++ ++ Q+M PL+HY+I++SHNTYL QF G + + Y + L GCR VELD
Sbjct: 288 CDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELD 347
Query: 361 CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM 420
D G D EPI+ + M T + F+ VI+ I + AFV SEYP+IL NHCS QQ M
Sbjct: 348 VSD--GSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVM 405
Query: 421 SKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM 480
++ + +FG+ L +A PL LPSP LKR I++K K+L
Sbjct: 406 AQQMKKVFGNKLYTEA----PLPSESYLPSPEKLKRMIIVKGKKL--------------- 446
Query: 481 MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLV 540
S ++LE E D++EEA + +S D G ++ +
Sbjct: 447 ------PSDPDVLEG------EVTDEDEEA----EMSRRMSVDYNGEQKQI--------- 481
Query: 541 TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG 600
+ LS +++ + V+++ F ++ + ++ M SF+E+
Sbjct: 482 -------------------RLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEA 522
Query: 601 LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL 660
+ +FVNYNK+ +SRIYP R+DSSN PQ FWN GCQ+V++N+QTP M L
Sbjct: 523 SRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDL 582
Query: 661 NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKK--- 717
+ G F NG CGY+L+P MR F ++ + GV +++ISGQ K
Sbjct: 583 HTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGAC 642
Query: 718 -----IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRI 772
I YV ++++G+P D E RT+ V N NP++ +E+F F +V LP+LA++R
Sbjct: 643 AKGDVIDPYVCIEIHGIPADC--SEQRTKTVQQNSDNPIF-DETFEF-QVNLPELAMIRF 698
Query: 773 AVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVL 820
V DD+ ++ IGQ +P + LQ GYRH+ LR+ + T+F +I +
Sbjct: 699 VVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 749
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 298 bits (764), Expect = 2e-80
Identities = 210/637 (32%), Positives = 321/637 (50%), Gaps = 99/637 (15%)
Query: 196 NDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRL 255
ND ++ + E+F + + I R +I ++F + ++ L L FL + Q +
Sbjct: 47 NDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRK-ILLASNLAQFLTQEQYAAEM 105
Query: 256 NEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEM 315
++ + A +II+ YEP E+++K +S +GF RY+ S E + ++YQ+M
Sbjct: 106 SKAI--------AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDM 157
Query: 316 DHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITH 375
HPL YFISSSHNTYL Q G S + Y L+ GCRC+E+DCWDG EP++ H
Sbjct: 158 THPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGA--QNEPVVYH 215
Query: 376 GKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQ 435
G + + +LFK VIQAI + AF+TS+YPV+LS ENHCS QQ M+ + FG+ LL
Sbjct: 216 GYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSD 275
Query: 436 ALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESASPANILED 495
L+ P LPSP LK KIL V+ K++ L+ E S
Sbjct: 276 MLDDFP----DTLPSPEALKFKIL---------VKNKKIGTLKETHERKGS--------- 313
Query: 496 DNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKK--GLVTVEDEQAWMASYK 553
D G + VKK G++ + ++
Sbjct: 314 ---------------------------DKRGDNQDKETGVKKLPGVMLFKKKKT------ 340
Query: 554 YVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG------LGYLKTH 607
I LS ++ Y + KF+ F + + Y + N S+G L L+ H
Sbjct: 341 ---RKLKIALALSDLVIYTKAEKFKSF----QHSRLYQQFNENNSIGETQARKLSKLRVH 393
Query: 608 AIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEY 667
EF+ + ++ ++RIYPK R DSSN+ PQ FWN GCQMV+LN+QTP L M L GKF
Sbjct: 394 --EFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLD 451
Query: 668 NGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFL-----SDKKIGTYV 722
NG GY+LKP F+R F+P + + + T ++++ISG L S K + V
Sbjct: 452 NGGSGYILKPHFLRESKSYFNP---SNIKEGMPITLTIRLISGIQLPLTHSSSNKGDSLV 508
Query: 723 EVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDD----N 778
++++G+P D ++++ TR++ N +P +N E+F F + +P+LA++R V
Sbjct: 509 IIEVFGVPNDQMKQQ--TRVIKKNAFSPRWN-ETFTF-IIHVPELALIRFVVEGQGLIAG 564
Query: 779 NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815
N+ +GQ LPL + GYR I L + + L ++F
Sbjct: 565 NEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASLF 601
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 204 bits (518), Expect = 5e-52
Identities = 129/337 (38%), Positives = 188/337 (55%), Gaps = 30/337 (8%)
Query: 269 MQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRL-ELYQEMDHPLAHYFISSS 327
+ II+ +EP + +GL+S +GF R+LM EN D E +E+ PL++Y+I SS
Sbjct: 1347 LSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLSYYYIESS 1406
Query: 328 HNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKD 387
HNTYLTG Q G+SSVE+Y QVLL GCR VELDCWDG +D PII HG + T I FK+
Sbjct: 1407 HNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDG--DDGMPIIYHGHTLTTKIPFKE 1464
Query: 388 VIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRA 447
V++AI +AF+ S+ P+I+S ENHCS QQ KM++ + +FG+ L+ + L
Sbjct: 1465 VVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLVTKFLFETDFSDDPM 1524
Query: 448 LPSPNDLKRKILIKNKRLKP-----EVEKKQLEALRSMMEAGESASPANILEDDNEEEIE 502
LPSP+ L++K+L+KNK+LK ++ K++ L SM + AN +NEEE +
Sbjct: 1525 LPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQAYNGGNANPRPANNEEEED 1584
Query: 503 SADQEE------------EAHPEFKFGNELSADDLGH------KEAVANSVKKGLVTVED 544
D+ + E PE K N+ + K+A ++ KG V +
Sbjct: 1585 EEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYNEEIPKRIKKADNSACNKGKVYDME 1644
Query: 545 --EQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQG 579
E+ ++ K + I P LS ++ Y Q VKF G
Sbjct: 1645 LGEEFYLDQNK--KESRQIAPELSDLVIYCQAVKFPG 1679
Score = 154 bits (388), Expect = 6e-37
Identities = 91/235 (38%), Positives = 137/235 (58%), Gaps = 12/235 (5%)
Query: 590 YNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSL 649
Y++SS NE+ + ++ + + Q+ R YP R+DSSN P +FW G Q+V+L
Sbjct: 1755 YHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVAL 1814
Query: 650 NYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPD----RTFDPFSETPVDGVIAATCSV 705
NYQT DL + LN FE NG CGY+LKP + + + F P E +D + A S+
Sbjct: 1815 NYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPL-ERDLDSMDPAVYSL 1873
Query: 706 QVISGQFL--SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVI 763
++SGQ + S+ +EVD+ G+P D+ FRT+ + N LNP++NE+ F+F V
Sbjct: 1874 TIVSGQNVCPSNSMGSPCIEVDVLGMPLDSC--HFRTKPIHRNTLNPMWNEQ-FLFH-VH 1929
Query: 764 LPDLAVLRIAVYDDNNKLI-GQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCN 817
DL LR AV ++N+ + QRI+PL L+ GYRH+ LRN N+ L + ++F N
Sbjct: 1930 FEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFIN 1984
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 174 bits (442), Expect = 3e-43
Identities = 115/325 (35%), Positives = 165/325 (50%), Gaps = 58/325 (17%)
Query: 290 DGFCRYLMSDENAPVFLDRLELY--QEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYR 347
D F +L S EN+ V+ +L+ M++PL+HY+ISSSHNTYLTG QF +SS+E Y
Sbjct: 296 DEFVTFLFSKENS-VWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYA 354
Query: 348 QVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILS 407
+ L GCRC+ELDCWD G D P+I HG + T I F DV+ IKE AFV SEYPVILS
Sbjct: 355 RCLRMGCRCIELDCWD--GPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS 412
Query: 408 FENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKP 467
E+HCS QQ M++Y + + GD LL + +E LPSPN LKRKILIK+K+L
Sbjct: 413 IEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEI----SADGLPSPNQLKRKILIKHKKLAE 468
Query: 468 EVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGH 527
+++ P +++ +N+
Sbjct: 469 GSAYEEV--------------PTSMMYSEND----------------------------- 485
Query: 528 KEAVANSVKKGLVTVED--EQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEE 585
++NS+K G++ +ED W Y +V ++ I+ T + + + V+
Sbjct: 486 ---ISNSIKNGILYLEDPVNHEWYPHY-FVLTSSKIYYSEETSSDQGNEDEEEPKEVSSS 541
Query: 586 RNIHYNMSSFNESVGLGYLKTHAIE 610
+H N F+ +G G H E
Sbjct: 542 TELHSNEKWFHGKLGAGRDGRHIAE 566
Score = 172 bits (437), Expect = 1e-42
Identities = 104/299 (34%), Positives = 164/299 (54%), Gaps = 13/299 (4%)
Query: 528 KEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERN 587
+E + + VKK + A + K + I LS ++ Y +PV F + ER
Sbjct: 916 QEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERA 975
Query: 588 IHYNMSSFNESVGLGYL-KTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQM 646
+ +MSSF E+ Y+ K +F+ YN+ Q+SRIYPKG R+DSSNY P W G Q+
Sbjct: 976 CYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQL 1035
Query: 647 VSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQ 706
V+LN+QTPD MQ+NQ F CGY+L+P MR D FDPF ++ + G+ S++
Sbjct: 1036 VALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR--DEAFDPFDKSSLRGLEPCAISIE 1093
Query: 707 VISGQFLSDKKIG---TYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVI 763
V+ + L G +VE+++ G D+ ++ +T V++NGLNPV+ + F F ++
Sbjct: 1094 VLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ--KTEFVVDNGLNPVWPAKPFHF-QIS 1150
Query: 764 LPDLAVLRIAVYDD----NNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNI 818
P+ A LR VY++ + + Q P+ GL+ GYR + L+N ++ L L ++ I
Sbjct: 1151 NPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKI 1209
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 174 bits (442), Expect = 3e-43
Identities = 115/325 (35%), Positives = 165/325 (50%), Gaps = 58/325 (17%)
Query: 290 DGFCRYLMSDENAPVFLDRLELY--QEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYR 347
D F +L S EN+ V+ +L+ M++PL+HY+ISSSHNTYLTG QF +SS+E Y
Sbjct: 296 DEFVTFLFSKENS-VWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYA 354
Query: 348 QVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILS 407
+ L GCRC+ELDCWD G D P+I HG + T I F DV+ IKE AFV SEYPVILS
Sbjct: 355 RCLRMGCRCIELDCWD--GPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS 412
Query: 408 FENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKP 467
E+HCS QQ M++Y + + GD LL + +E LPSPN LKRKILIK+K+L
Sbjct: 413 IEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEI----SADGLPSPNQLKRKILIKHKKLAE 468
Query: 468 EVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGH 527
+++ P +++ +N+
Sbjct: 469 GSAYEEV--------------PTSMMYSEND----------------------------- 485
Query: 528 KEAVANSVKKGLVTVED--EQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEE 585
++NS+K G++ +ED W Y +V ++ I+ T + + + V+
Sbjct: 486 ---ISNSIKNGILYLEDPVNHEWYPHY-FVLTSSKIYYSEETSSDQGNEDEEEPKEVSSS 541
Query: 586 RNIHYNMSSFNESVGLGYLKTHAIE 610
+H N F+ +G G H E
Sbjct: 542 TELHSNEKWFHGKLGAGRDGRHIAE 566
Score = 172 bits (437), Expect = 1e-42
Identities = 104/299 (34%), Positives = 164/299 (54%), Gaps = 13/299 (4%)
Query: 528 KEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERN 587
+E + + VKK + A + K + I LS ++ Y +PV F + ER
Sbjct: 916 QEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERA 975
Query: 588 IHYNMSSFNESVGLGYL-KTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQM 646
+ +MSSF E+ Y+ K +F+ YN+ Q+SRIYPKG R+DSSNY P W G Q+
Sbjct: 976 CYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQL 1035
Query: 647 VSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQ 706
V+LN+QTPD MQ+NQ F CGY+L+P MR D FDPF ++ + G+ S++
Sbjct: 1036 VALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR--DEAFDPFDKSSLRGLEPCAISIE 1093
Query: 707 VISGQFLSDKKIG---TYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVI 763
V+ + L G +VE+++ G D+ ++ +T V++NGLNPV+ + F F ++
Sbjct: 1094 VLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ--KTEFVVDNGLNPVWPAKPFHF-QIS 1150
Query: 764 LPDLAVLRIAVYDD----NNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNI 818
P+ A LR VY++ + + Q P+ GL+ GYR + L+N ++ L L ++ I
Sbjct: 1151 NPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKI 1209
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 173 bits (438), Expect = 1e-42
Identities = 141/422 (33%), Positives = 215/422 (50%), Gaps = 40/422 (9%)
Query: 60 LECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENP 119
L+ I IR G K+ K +AV + E+ + GT V +S + A++
Sbjct: 65 LDIMEIKEIRPG---KNSKDFERAKAVRQKEDCC----FTILYGTQFV-LSTLSLAADSK 116
Query: 120 EVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGK--IPVRSITRTFASGK 177
E W+ GL+ I+H A N S T ++ K + + + I +R +
Sbjct: 117 EDAVNWLSGLK-ILHQ-EAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLIN 174
Query: 178 TEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKIC--PRTDIEDLFKKI------ 229
+ + LK+ + G + + S+E+F+ +K+ + I D FKK
Sbjct: 175 FKVSSAKFLKDKFVEIGAHKD----ELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFIL 230
Query: 230 -NGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKK-KGLI 287
N D+ D V +L++ QR + D + + + + D + + +
Sbjct: 231 GNTDRPDASAV-----YLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFL 285
Query: 288 SSDGFCRYLMSDENAPVFLDRLELY--QEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEM 345
D F YL S EN+ ++ ++ + Q+M++PL+HY+ISSSHNTYLTG Q +SS E
Sbjct: 286 FVDEFLTYLFSRENS-IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEA 344
Query: 346 YRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVI 405
Y + L GCRC+ELDCWDG D +P+I HG T I F DV+QAIK+ AFVTS +PVI
Sbjct: 345 YIRCLRMGCRCIELDCWDGP--DGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVI 402
Query: 406 LSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRL 465
LS E HCS QQ M+K +++FGDLLL + E+ LPSP+ L+ KI+IK+K+L
Sbjct: 403 LSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEA----SADQLPSPSQLREKIIIKHKKL 458
Query: 466 KP 467
P
Sbjct: 459 GP 460
Score = 125 bits (315), Expect = 2e-28
Identities = 86/279 (30%), Positives = 147/279 (52%), Gaps = 23/279 (8%)
Query: 553 KYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFV 612
KY +I LS ++ Y +P ++ E + SF E+ ++ ++ +
Sbjct: 918 KYWEKNQSIAIELSDLVVYCKPTSKTKDNL--ENPDFREIRSFVETKADSIIRQKPVDLL 975
Query: 613 NYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCG 672
YN++ ++R+YPKG RVDSSNY P W G QMV+LN+QT D MQ+N F NG G
Sbjct: 976 KYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTG 1035
Query: 673 YLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIG-----TYVEVDMY 727
Y+L+P+ MR +DP I T +V+V+ + L K+G +VEV++
Sbjct: 1036 YVLQPESMR--TEKYDPMPPES-QRKILMTLTVKVLGARHL--PKLGRSIACPFVEVEIC 1090
Query: 728 GLPTDTIRKEFRTRMVMNNGLNPVY--NEESFVFRKVILPDLAVLRIAVYDD----NNKL 781
G D +F+T +V +NGL+P++ +E F ++ P+LA LR VY++ +
Sbjct: 1091 GAEYD--NNKFKTTVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNF 1147
Query: 782 IGQRILPLDGLQAGYRHISLRNEGNKPLSLPT--IFCNI 818
+ P+ +++G+R + L+N ++ + L + +FC +
Sbjct: 1148 LAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEM 1186
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 64.3 bits (155), Expect = 7e-10
Identities = 61/257 (23%), Positives = 118/257 (45%), Gaps = 28/257 (10%)
Query: 928 YLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYD--------KEKSTHEKIL 979
Y K Q+K++ +K+K + T++K Q K+ + + KEK + K+L
Sbjct: 945 YETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKML 1004
Query: 980 EKAMKKKGGSNCLEMKKETEIK--IQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQE 1037
E A G + + ET K I++LT H+ ++ ++++ W + +N + E QE
Sbjct: 1005 EMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISI----WEKKLNQQAEELQE 1060
Query: 1038 IRDLHLSQQ----CELLKKLLINAHEQQTQQLKLS--------HDRESKEMRAHQAKISM 1085
I ++ L ++ EL +K+L+ E++ +++ D E++ Q K
Sbjct: 1061 IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQ-EQLKQKS 1119
Query: 1086 ENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLE 1145
+ +++QD++ K KA E+ +LN S + + + + +K E D+ K +L
Sbjct: 1120 AHVNSLAQDET-KLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKL 1178
Query: 1146 FLEKQNEQLLKSCHAVS 1162
+ Q LKS H S
Sbjct: 1179 KTTDEEFQSLKSSHEKS 1195
Score = 51.2 bits (121), Expect = 6e-06
Identities = 63/339 (18%), Positives = 152/339 (44%), Gaps = 27/339 (7%)
Query: 842 LSITEKRADQMRAMGIE-TSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAA 900
L + E+ Q+R+ + T+ ++ K+++ KA T Q + E R A
Sbjct: 377 LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKA- 435
Query: 901 LASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ 960
E + I+ I + E+ ++ L +K Q+ ++ +KK ++ + +QKLH +
Sbjct: 436 -----EMDEQIKTIEKTSEEERISLQQELSRVK--QEVVDVMKKSSEEQIAKLQKLHEKE 488
Query: 961 VDKIVAQYDKEKSTHEKILEKAMK---KKGGSNCLEMK-----------KETEIKIQTLT 1006
+ + + K+ T E+ ++ MK +K S L++ +E E++ + +
Sbjct: 489 LARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAIL 548
Query: 1007 SDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLI--NAHEQQTQQ 1064
++ ++K++++ + + ++ S+ E+ +++ + +Q +L L N H ++
Sbjct: 549 TESENKLRDLQQEAETYRTRILELESSLEKSLQE-NKNQSKDLAVHLEAEKNKHNKEITV 607
Query: 1065 LKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKR 1124
+ H E + ++ Q + E + + Q + + RE+ +E + K + +
Sbjct: 608 MVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAH 667
Query: 1125 LAMKQSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQ 1163
+ K +++L Q E LE L + ++LK+ H + +
Sbjct: 668 IEEMNEKTLEKLDVKQTE-LESLSSELSEVLKARHKLEE 705
Score = 49.3 bits (116), Expect = 2e-05
Identities = 70/354 (19%), Positives = 145/354 (40%), Gaps = 49/354 (13%)
Query: 817 NIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSD--TSKNDK 874
NI K + + F D+ L + + I E++ ++ + + ++ V + TSK +K
Sbjct: 1824 NIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEK 1883
Query: 875 ----------KGKANTAKANVTPQSSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQ 924
+ N +S S L L S +EA+ E KQ
Sbjct: 1884 LQALQQMDGRNKPTELLEENTEEKSKSHL---VQPKLLSNMEAQHNDLEFKLAGAEREKQ 1940
Query: 925 MKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMK 984
K + + QK+L L+K+H +E ++K +YD+E+ K ++ ++
Sbjct: 1941 KLG--KEIVRLQKDLRMLRKEHQQELEILKK-----------EYDQEREEKIKQEQEDLE 1987
Query: 985 KKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLS 1044
K S ++ +E ++ + + +K E IN E E+ + H
Sbjct: 1988 LKHNSTLKQLMREFNTQLAQKEQELEMTIK-----------ETINKAQEVEAELLESHQE 2036
Query: 1045 QQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERE 1104
+ +LLKK+ ++ LK + R + + A + +++ + +Q + ++ K +++
Sbjct: 2037 ETNQLLKKI-----AEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQK 2091
Query: 1105 RRVRELNSSNTKKFLEERKRLAMK-----QSKEMDQLKKVQLEHLEFLEKQNEQ 1153
E ++ +E + +LA K SK +Q + Q+ +LE K+ E+
Sbjct: 2092 LEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEK 2145
Score = 42.7 bits (99), Expect = 0.002
Identities = 49/239 (20%), Positives = 103/239 (43%), Gaps = 23/239 (9%)
Query: 919 IEDLKQMKAY--LKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHE 976
+ED +K L+ K+Q+ L K+ + H L ++ + + Q D+ E
Sbjct: 272 VEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELE 331
Query: 977 KILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQ 1036
KI + M +K + + ++ + I+ L D K +V TK +M T +E+
Sbjct: 332 KIKDLHMAEK--TKLITQLRDAKNLIEQLEQD-----KGMVIAETKR--QMHETLEMKEE 382
Query: 1037 EIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKS 1096
EI L + TQ +L +E E A + ++ +++
Sbjct: 383 EIAQLRS------------RIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEAR 430
Query: 1097 IKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQLL 1155
K KAE + +++ + ++ ++ + ++ L+ + + +D +KK E + L+K +E+ L
Sbjct: 431 RKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKEL 489
Score = 36.6 bits (83), Expect = 0.15
Identities = 63/305 (20%), Positives = 128/305 (41%), Gaps = 44/305 (14%)
Query: 888 QSSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQ---MKAYLKHLKKQQKELNSLKK 944
+ E+ L G E ++ + I ++ E +KQ + + LK++ +NSL +
Sbjct: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ 1127
Query: 945 KHAKEHSTMQKLHCTQVDKIVAQ--YDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKI 1002
K + ++KL ++K + + + +E+ K+L + K+K S K T+ +
Sbjct: 1128 DETKLKAHLEKLE-VDLNKSLKENTFLQEQLVELKMLAEEDKRK-VSELTSKLKTTDEEF 1185
Query: 1003 QTLTSDHKSKVK--------------------EIVAQHTK-----EWSEMINTHSAEEQE 1037
Q+L S H+ K +I + T+ + +E+IN S++
Sbjct: 1186 QSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNA 1245
Query: 1038 I--RDLHLSQQCELLKKLLI----NAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAI 1091
I R H + +K+ L+ E + Q +L+ ++ + + QA +E +
Sbjct: 1246 ILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKE-- 1303
Query: 1092 SQDKSIKNKAE---RERRVRELNSSNTKKFLEERKRLAMKQSKEM-DQLKKVQLEHLEFL 1147
+Q KS+K E E+ + N ++ E++ + KE+ + + V L E
Sbjct: 1304 NQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELK 1363
Query: 1148 EKQNE 1152
EK+ E
Sbjct: 1364 EKKVE 1368
Score = 36.2 bits (82), Expect = 0.19
Identities = 54/254 (21%), Positives = 119/254 (46%), Gaps = 34/254 (13%)
Query: 911 IELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDK 970
++ + + +I L+Q+ + + +K+ S +H +T+++L K Y+K
Sbjct: 1421 VDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQH---QNTVKELQIQLELKSKEAYEK 1477
Query: 971 EKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINT 1030
++ + + E+ ++ +CL+ + E D KSK+++ + E + +
Sbjct: 1478 DEQIN-LLKEELDQQNKRFDCLKGEME----------DDKSKMEKKESNLETE----LKS 1522
Query: 1031 HSAEEQEIRDLHLSQ---QCELLKKLLINAHEQQTQQ-----LKLSHDRESKEMRAHQAK 1082
+A E+ D H++Q + E L ++L N ++Q+ + KL H +E E + ++ K
Sbjct: 1523 QTARIMELED-HITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVK 1581
Query: 1083 ISMENSKAISQDKSIKNKAERERRVRELNSSN--TKKFLEERK----RLAMKQSKEMDQL 1136
+ E + +++ KAE E + +EL N K EE K RL + + ++ +L
Sbjct: 1582 EAEEKILTL-ENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAEL 1640
Query: 1137 KKVQLEHLEFLEKQ 1150
K+ + + ++KQ
Sbjct: 1641 KRKAEQKIAAIKKQ 1654
Score = 34.7 bits (78), Expect = 0.56
Identities = 63/313 (20%), Positives = 120/313 (38%), Gaps = 48/313 (15%)
Query: 865 VPSDTSKNDKKGKANTAKANVTPQSSSE---------LRPTTTAALASGVEAKKGIELIP 915
V DT+ N+ + + A+V + E L +L ++ + +
Sbjct: 1102 VKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELK 1161
Query: 916 QVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTH 975
+ ED +++ LK +E SLK H K + +++ +KS
Sbjct: 1162 MLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLE----------------DKSLE 1205
Query: 976 EKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEE 1035
K L + + + C + + E K L + SK I+++ I+
Sbjct: 1206 FKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSR--------ISHCQHRT 1257
Query: 1036 QEIRDLHLSQQC---ELLKKLLINAHEQQTQQL---KLSHDRESKEMRAHQAKISMEN-- 1087
++++ L + C EL +L EQ T + + +H E KE + K +E+
Sbjct: 1258 TKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLV 1317
Query: 1088 --SKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHL- 1144
+A+ ++ + +A E +E + KK L E +E+ + KKV++ L
Sbjct: 1318 TEKEALQKEGGNQQQAASE---KESCITQLKKELSENINAVTLMKEELKE-KKVEISSLS 1373
Query: 1145 EFLEKQNEQLLKS 1157
+ L N QL S
Sbjct: 1374 KQLTDLNVQLQNS 1386
Score = 34.7 bits (78), Expect = 0.56
Identities = 50/280 (17%), Positives = 120/280 (42%), Gaps = 42/280 (15%)
Query: 911 IELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDK 970
+ L + + E+LK ++ L+ + +L LK+K ++ + ++K +Q+++ QY K
Sbjct: 1611 VNLSVKSKEEELKALEDRLE--SESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKK 1668
Query: 971 --------------EKSTHEKILEKAMKK------------KGGSNCLEMKKETEIKIQT 1004
E+ ILE+ +K + N ++ E Q
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728
Query: 1005 LTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAH---EQQ 1061
+ ++ ++ E +++ E++E H +C+ ++L+ H +Q
Sbjct: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQH 1788
Query: 1062 TQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEE 1121
Q + H +E E+ K S+ ++ + ++ KN + ++ + + + +K L+E
Sbjct: 1789 EDQSMIGHLQE--ELEEKNKKYSLIVAQHVEKEGG-KNNIQAKQNLENV-FDDVQKTLQE 1844
Query: 1122 RK---RLAMKQSKEMD----QLKKVQLEHLEFLEKQNEQL 1154
++ ++ ++ KE+D + K+V +E L + E+L
Sbjct: 1845 KELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKL 1884
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sapiens]
Length = 570
Score = 59.3 bits (142), Expect = 2e-08
Identities = 62/296 (20%), Positives = 132/296 (44%), Gaps = 40/296 (13%)
Query: 906 EAKKGIE----LIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQV 961
E K+ +E L+PQ +Q++A HL K+ + +++ + +E+ +L+ Q
Sbjct: 234 ELKRKLERAKLLLPQ------QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE 287
Query: 962 DKIVAQYDKEKSTHEKILEKAMKKKGGSNCL----EMKKETEIKI---QTLTSDHKSKVK 1014
+K+ Q +K + EKI E+ K + + EM E E K+ + + + + K++
Sbjct: 288 EKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 347
Query: 1015 EIVAQ-HTKEWSEMINTHSAEEQEIRDLHLSQQCELL------------KKLLINAHEQQ 1061
E+ + H +E EE++IR+ Q+ E +K+ Q
Sbjct: 348 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQ 407
Query: 1062 TQQLKLSHDRES-----KEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTK 1116
Q+ K+ E +EM+ + K+ + K Q+K I+ + E+ R E+ +
Sbjct: 408 EQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEE 467
Query: 1117 KFLEERKRLAMKQSKEMDQLKKVQLEHLEFLE-----KQNEQLLKSCHAVSQTQGE 1167
K E+ ++ +++K +Q +K++ + + E ++ E+ ++ + Q Q E
Sbjct: 468 KMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEE 523
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 58.2 bits (139), Expect = 5e-08
Identities = 53/263 (20%), Positives = 115/263 (43%), Gaps = 29/263 (11%)
Query: 919 IEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKI 978
+E QM+AY + +++ ++E L +K + T+Q LH + + DKE +
Sbjct: 434 LEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSNSNRDKEIKKLNEE 493
Query: 979 LEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHT----------KEWSEMI 1028
+E+ K SN LE + E + ++ D +++ + QH K+ E
Sbjct: 494 IERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQEKEELHKQLVEAS 553
Query: 1029 NTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENS 1088
++ +E++D H ++ L + +N ++ +L+ + S+++R + ++ +
Sbjct: 554 ERLKSQAKELKDAHQQRKLALQEFSELN---ERMAELRAQKQKVSRQLRDKEEEMEVATQ 610
Query: 1089 KAISQDKSIKNKAERERRVRE-------LNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ- 1140
K + + ++ +AE+ R+ E +S +K E + + E++ LK Q
Sbjct: 611 KVDAMRQEMR-RAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQG 669
Query: 1141 -------LEHLEFLEKQNEQLLK 1156
LEH + + K +L K
Sbjct: 670 GRGAGATLEHQQEISKIKSELEK 692
Score = 42.4 bits (98), Expect = 0.003
Identities = 68/352 (19%), Positives = 153/352 (43%), Gaps = 51/352 (14%)
Query: 832 VDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSS 891
V +L + LS R +++ + E + + +D+++ +++ + A S+
Sbjct: 468 VQSLHGSSRALS-NSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQ 526
Query: 892 ELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHS 951
LR G+E K ++ Q + E KQ+ + LK Q KEL K H +
Sbjct: 527 RLR---------GLE--KQHRVVRQEKEELHKQLVEASERLKSQAKEL---KDAHQQRKL 572
Query: 952 TMQKLHCTQVDKIVAQYDKEKS-THEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHK 1010
+Q+ +++++ +A+ +K ++ +K + + + ++ ++ + + L + +
Sbjct: 573 ALQEF--SELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKELE 630
Query: 1011 SKVKEIVAQHTKEWSEMINTHSAE-----EQEIRDLHLSQ------------------QC 1047
+++ + VA+ +KE + HS E E+ L + Q +
Sbjct: 631 AQLDDAVAEASKE--RKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQQEISKIKS 688
Query: 1048 ELLKKLLINAHEQQTQQLKLSHDRESKEMR-----AHQAKISMENSKAISQDKSIKNKAE 1102
EL KK+L +E++ + + SH E K ++ + +++++ + +DK K+K E
Sbjct: 689 ELEKKVLF--YEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEILMLKDKLEKSKRE 746
Query: 1103 RERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQL 1154
R + E + K+ ER L ++K++ + ++ L QN QL
Sbjct: 747 RHNEMEEAVGTIKDKYERERAML-FDENKKLTAENEKLCSFVDKLTAQNRQL 797
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 56.6 bits (135), Expect = 1e-07
Identities = 62/294 (21%), Positives = 127/294 (43%), Gaps = 46/294 (15%)
Query: 940 NSLKKKHAKEHSTMQKLHCTQVDKIVAQYDK---------EKSTHEKILEKAMKKKGGS- 989
N +K K S ++ + + + Y K +K EK E+ K K GS
Sbjct: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
Query: 990 --NCLEM---KKETEIKIQTLTSDHK----SKVKEIVAQHTKEWSEMINTHSAEEQEIRD 1040
N +E+ +K TE + +T+ K S + + ++ S+ I+ H E+E ++
Sbjct: 204 GENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKE 263
Query: 1041 LHLSQQCELL-----------------KKLLINAHEQQTQQLKLSHDRESKEMRAHQAKI 1083
+++ L ++ I A E+ Q + + E +E + K
Sbjct: 264 RAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKR 323
Query: 1084 SMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEH 1143
+ E + I +++ K AE +R++E K+ EER+R+ ++ + ++ ++ + E
Sbjct: 324 AAEERQRIKEEE--KRAAEERQRIKE----EEKRAAEERQRIKEEEKRAAEERQRARAEE 377
Query: 1144 LEFL----EKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQNA 1193
E +K+N+QL + HA+ +T+ +G+ + +I + + KLQ A
Sbjct: 378 EEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTA 431
Score = 38.1 bits (87), Expect = 0.050
Identities = 58/278 (20%), Positives = 113/278 (40%), Gaps = 49/278 (17%)
Query: 906 EAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIV 965
E K+ E + R E+ ++ K + KQ +E KKHA + + ++ Q KI
Sbjct: 362 EEKRAAEERQRARAEEEEKAKVEEQKRNKQLEE-----KKHAMQETKIKGEKVEQ--KIE 414
Query: 966 AQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDH----KSKVKEIVAQHT 1021
++ EK E L+ A+ KK G E + + K + L D K ++K+ +
Sbjct: 415 GKWVNEKKAQEDKLQTAVLKKQGE---EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKD 471
Query: 1022 KEWSEMINTHSAEEQEIRDLHLSQQCELLKKLL--------------------------I 1055
KE E + + ++ ++ SQ E + L +
Sbjct: 472 KEPKEEVKSFMDRKKGFTEVK-SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV 530
Query: 1056 NAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNT 1115
A ++ + + + ES+E K+ + +A + + +K K E R+V E
Sbjct: 531 EAGKRLEELRRRRGETESEEFE----KLKQKQQEAALELEELKKKREERRKVLEEEEQRR 586
Query: 1116 KKFLEERKRLAMKQSKEMDQLK-KVQLEHLEFLEKQNE 1152
K+ +RK +++ +E +LK +++ E EK+ +
Sbjct: 587 KQEEADRK---LREEEEKRRLKEEIERRRAEAAEKRQK 621
>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
Length = 1080
Score = 56.6 bits (135), Expect = 1e-07
Identities = 56/268 (20%), Positives = 124/268 (46%), Gaps = 30/268 (11%)
Query: 916 QVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTH 975
++ +E+ KQ L+ QQ++L + + K +K Q+ + Y+ H
Sbjct: 574 KLEVEEKKQAMLLLQRALAQQRDLTARRVKET------EKALSRQLQRQREHYEATIQRH 627
Query: 976 EKILEKAM--KKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSA 1033
+++ + KK C + E + + Q T +V + AQH E ++ SA
Sbjct: 628 LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTE----RVAQAQAQHELEIKKLKELMSA 683
Query: 1034 EEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRA-HQAKISMENSKA-- 1090
E+ R+ +S++ + +K++ + E + Q+L H +E + +++ H+A++ + +A
Sbjct: 684 TEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQ 743
Query: 1091 --ISQDKSIKNKAERERRV-----RELNSSNTKKFLE--------ERKRLAMKQSKEMDQ 1135
+ Q + ++ + ERE+ RE ++ LE +R+RL + ++E ++
Sbjct: 744 RCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERER 803
Query: 1136 LKKVQLEHLEFLEKQNEQLLKSCHAVSQ 1163
L + LE+ +QL +S A+++
Sbjct: 804 LGQQAARQRAELEELRQQLEESSSALTR 831
Score = 37.4 bits (85), Expect = 0.086
Identities = 54/239 (22%), Positives = 107/239 (44%), Gaps = 22/239 (9%)
Query: 921 DLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKE----KSTHE 976
++K++K + +K ++E +K + T++ L ++ K++A++ +E KS HE
Sbjct: 673 EIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLE-PEIQKLIARHKQEVRRLKSLHE 731
Query: 977 KILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWS-EMINTHSAEE 1035
L ++ ++ CL +E +++ + KE + Q +E + + H +E
Sbjct: 732 AELLQS-DERASQRCLRQAEELREQLE--------REKEALGQQERERARQRFQQHLEQE 782
Query: 1036 QEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDK 1095
Q L QQ + L + E+ QQ E +E+R + S ++A+ +
Sbjct: 783 QWA----LQQQRQRLYSEVAEERERLGQQAARQR-AELEELRQQLEESSSALTRALRAEF 837
Query: 1096 SIKNKAERERR-VRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQ 1153
K + E+ERR ELN+ + LE + A + KE L + E E + K ++
Sbjct: 838 E-KGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDK 895
>gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens]
Length = 1044
Score = 55.1 bits (131), Expect = 4e-07
Identities = 50/234 (21%), Positives = 110/234 (47%), Gaps = 27/234 (11%)
Query: 916 QVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTH 975
++ +E+ KQ L+ QQ++L + + K +K Q+ + Y+ H
Sbjct: 574 KLEVEEKKQAMLLLQRALAQQRDLTARRVKET------EKALSRQLQRQREHYEATIQRH 627
Query: 976 EKILEKAM--KKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSA 1033
+++ + KK C + E + + Q T +V + AQH E ++ SA
Sbjct: 628 LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTE----RVAQAQAQHELEIKKLKELMSA 683
Query: 1034 EEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRA-HQAKISMENSKA-- 1090
E+ R+ +S++ + +K++ + E + Q+L H +E + +++ H+A++ + +A
Sbjct: 684 TEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQ 743
Query: 1091 --ISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLE 1142
+ Q + ++ + ERE+ +ER+R +Q E+++L++ QLE
Sbjct: 744 RCLRQAEELREQLEREKEALG---------QQERERARQRQRAELEELRQ-QLE 787
Score = 40.0 bits (92), Expect = 0.013
Identities = 65/297 (21%), Positives = 124/297 (41%), Gaps = 44/297 (14%)
Query: 896 TTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQK 955
T+ L VE KK L+ Q + + + A + +K+ +K L+ ++ + + +
Sbjct: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTA--RRVKETEKALSRQLQRQREHYEATIQ 625
Query: 956 LHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNC------------LEMKKETEIKIQ 1003
H +D+++ DK+ + + A K+ C LE+KK E+
Sbjct: 626 RHLAFIDQLIE--DKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSA 683
Query: 1004 T-------LTSDHKSKVKEIVAQHTK-EWSEMINTHSAEEQEIRDLH----------LSQ 1045
T S+ K+KE+ + + E ++I H E + ++ LH SQ
Sbjct: 684 TEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQ 743
Query: 1046 QC----ELLKKLLINAHE----QQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSI 1097
+C E L++ L E Q+ ++ + E +E+R + S ++A+ +
Sbjct: 744 RCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFE- 802
Query: 1098 KNKAERERR-VRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQ 1153
K + E+ERR ELN+ + LE + A + KE L + E E + K ++
Sbjct: 803 KGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDK 859
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 54.3 bits (129), Expect = 7e-07
Identities = 68/338 (20%), Positives = 154/338 (45%), Gaps = 38/338 (11%)
Query: 843 SITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAALA 902
++ E RA Q A GI D+ S +++ ++ +A Q EL+ +A
Sbjct: 1363 AVVEARA-QASAAGILEEDLRTARSALKLKNEEVESERERAQAL-QEQGELK------VA 1414
Query: 903 SGVEAKKGIELIPQV---RIEDLKQMKAYLKHLKKQQK------ELNSLKKKHAKEHSTM 953
G ++ + L+ Q R E+++ ++ ++ L+KQ++ EL SL K + +
Sbjct: 1415 QGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDL 1474
Query: 954 QKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKI---QTLTSDHK 1010
Q+ +++K + + ++ +K ++ LE +ET+ + Q L + K
Sbjct: 1475 QQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKK 1534
Query: 1011 SKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCE--LLKKLLINAHEQQTQQLKLS 1068
++ E ++ + + T E+ + H +C+ L+K+L +++TQ++ L+
Sbjct: 1535 DQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKEL---EGQRETQRVALT 1591
Query: 1069 H-----DRESKEMRAHQAKI-SMENSKAI------SQDKSIKNKAERERRVRELNSSNTK 1116
H + S+E++A ++I +E+ + +D+ +K++ E+ ++ T+
Sbjct: 1592 HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQ 1651
Query: 1117 KFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQL 1154
LE R + M Q + + L+ + + LE+ EQ+
Sbjct: 1652 D-LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQI 1688
Score = 47.0 bits (110), Expect = 1e-04
Identities = 56/255 (21%), Positives = 131/255 (51%), Gaps = 28/255 (10%)
Query: 957 HCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNC-LEMK---KETEIK-IQTLTSDHKS 1011
H +V+++ +++KE+S H++ L KA++ LEM+ ++TE++ IQ + ++
Sbjct: 851 HEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERT 910
Query: 1012 KVKEIVAQ----HTKEWSEMINTHSAEEQEIRDLHLSQQCELLKK--LLINAHEQQTQQL 1065
+ + + Q KE ++ T ++E+ D SQQ E L++ + EQ+T +
Sbjct: 911 QAESALCQMQLETEKERVSLLETLLQTQKELAD--ASQQLERLRQDMKVQKLKEQETTGI 968
Query: 1066 KLSHDRESKEMRAHQAKISMENSKAISQDKS--IKNKAERERRVRELNS-----SNTKKF 1118
+ +E++ A+ ++ A+ ++ S +++K + +++V +L S ++++
Sbjct: 969 LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL 1028
Query: 1119 LEERKRLAMKQSKEMDQLKKVQLEH------LEFLEKQNEQLLKSCHAVSQTQGEGDAAD 1172
+E+ + +++++E ++++K +LE L +EK+ ++LL A S Q E A
Sbjct: 1029 VEQEVQEKLRETQEYNRIQK-ELEREKASLTLSLMEKE-QRLLVLQEADSIRQQELSALR 1086
Query: 1173 GEIGSRDGPQTSNSS 1187
++ G Q S+
Sbjct: 1087 QDMQEAQGEQKELSA 1101
Score = 37.0 bits (84), Expect = 0.11
Identities = 78/396 (19%), Positives = 169/396 (42%), Gaps = 53/396 (13%)
Query: 834 ALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSEL 893
A + ++ L + E+ A ++R + +E + D+++ K+ + V + +
Sbjct: 471 AREELRQQLEVLEQEAWRLRRVNVELQ----LQGDSAQGQKEEQQEELHLAVRERERLQ- 525
Query: 894 RPTTTAALASGVEAKKGIELIPQVRI-EDLKQMKAYLKHLKKQQKELNSL---KKKHAKE 949
+ G+EAK+ L + + E L+ + L+++Q E+ + ++ E
Sbjct: 526 ------EMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAE 579
Query: 950 HSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKG-GSNCLEMKKETEIKIQTLTSD 1008
S+ + T+V + A K + +E + A+ K G L++++E + + +
Sbjct: 580 LSSSENTLKTEVADLRAAAVKLSALNEAL---ALDKVGLNQQLLQLEEENQSVCSRMEAA 636
Query: 1009 HKSK----VKEIVAQHTKEWSEMINTH------SAEEQ------EIRDLHLSQQCELLKK 1052
+++ V A+ +E NTH AEE ++RD+ ++ E+ KK
Sbjct: 637 EQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKE-EIQKK 695
Query: 1053 LLINAHEQQ--TQQLKLSHDRESKE----MRAHQAKISMENSKAISQDKSIKNKAERERR 1106
L + H+Q+ T QL+ H ++ RA Q K ++ KA + + + +R+
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 1107 VRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLE-HLEFLEKQNEQLLKSCHAV---- 1161
+L ++ K L E +Q + ++ K QLE ++ + + E + +
Sbjct: 756 AEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL 815
Query: 1162 ----SQTQGEGDAADGEIGSRDGPQTSNSSMKLQNA 1193
SQ + E DAA ++ + Q ++++ Q A
Sbjct: 816 DTERSQAEQERDAAARQLAQAE--QEGKTALEQQKA 849
Score = 34.7 bits (78), Expect = 0.56
Identities = 76/379 (20%), Positives = 161/379 (42%), Gaps = 60/379 (15%)
Query: 850 DQMRAMGIETSDIADVPSDT-SKNDKKGKANTAKANVTPQSSSELRPTTTAALASGVEAK 908
+++ G + +V D +++ ++ KA A + + E T A S ++A
Sbjct: 1873 EELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQA- 1931
Query: 909 KGIELIPQVRIEDLKQMKAYLKHLKKQQK----ELNSLKKKHAKEHSTMQKLHCTQVDKI 964
+ + + R ++L+ ++A + + Q++ +L++ K H+ +Q +++
Sbjct: 1932 ---QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQA 1988
Query: 965 VAQYDKEKST------------HEKILEKAMKKKGGS---NCLEMKKETEIKIQTLTS-- 1007
E ST H + LE+A++ + G L +++ + Q L
Sbjct: 1989 ELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRD 2048
Query: 1008 -------DHKSKVKEIVAQHTKEWSEMINT-----HSAEEQEIRDLHLSQQCELLKKLLI 1055
+ + +++ +AQ +E MI EE+EIR LH S + EL +L +
Sbjct: 2049 EELRHQQEREQLLEKSLAQRVQE--NMIQEKQNLGQEREEEEIRGLHQSVR-EL--QLTL 2103
Query: 1056 NAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERE-RRVRELNSSN 1114
EQ+ +L+ + R + E H K S +++ D S++ + +RE R++
Sbjct: 2104 AQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLD-SLEPRLQRELERLQAALRQT 2162
Query: 1115 TKKFLEERKR-----LAMKQSK-EMDQLKKVQL-EHLEFLEKQNEQ--------LLKSCH 1159
+ +E R++ L++ Q+K + L++V + LE+ +EQ L +
Sbjct: 2163 EAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRAL 2222
Query: 1160 AVSQTQGEGDAADGEIGSR 1178
+ G + E+GSR
Sbjct: 2223 EKERLHSPGATSTAELGSR 2241
Score = 30.8 bits (68), Expect = 8.0
Identities = 34/178 (19%), Positives = 81/178 (45%), Gaps = 10/178 (5%)
Query: 893 LRPTTTAALASGVEAKKGIE-LIPQVRIEDLKQ--MKAYLKHLKKQQKELNSLKKKHAKE 949
L+ +++ L ++ +K +E L Q+ +D Q ++ ++ ++ +E N ++K+ +E
Sbjct: 994 LQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELERE 1053
Query: 950 HS--TMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTS 1007
+ T+ + Q ++ + D + L + M++ G +KE +++ L
Sbjct: 1054 KASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGE-----QKELSAQMELLRQ 1108
Query: 1008 DHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQL 1065
+ K K + +AQ + E+ +H E+Q L + +L + + E Q + L
Sbjct: 1109 EVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL 1166
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,809,618
Number of Sequences: 37866
Number of extensions: 1978271
Number of successful extensions: 12235
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 83
Number of HSP's successfully gapped in prelim test: 740
Number of HSP's that attempted gapping in prelim test: 9454
Number of HSP's gapped (non-prelim): 2814
length of query: 1194
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1080
effective length of database: 13,930,794
effective search space: 15045257520
effective search space used: 15045257520
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.