Search of human proteins with 32699064

Search of human proteins with 32699064

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32699064 WD repeat domain 53 [Homo sapiens]
         (358 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32699064 WD repeat domain 53 [Homo sapiens]                        732   0.0  
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             65   7e-11
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             65   7e-11
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             65   7e-11
gi|26665869 WD repeat domain 51B [Homo sapiens]                        65   9e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     62   6e-10
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]       60   2e-09
gi|32189425 WD repeat domain 69 [Homo sapiens]                         60   3e-09
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)...    59   7e-09
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    58   1e-08
gi|16554629 WD repeat domain 5 [Homo sapiens]                          57   3e-08
gi|16554627 WD repeat domain 5 [Homo sapiens]                          57   3e-08
gi|113865883 WD repeat domain 38 [Homo sapiens]                        57   3e-08
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]      56   6e-08
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ...    56   6e-08
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]               55   7e-08
gi|23199987 WD repeat domain 5B [Homo sapiens]                         55   1e-07
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...    54   2e-07
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H...    54   2e-07
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...    54   2e-07
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho...    54   2e-07
gi|8923881 WD SOCS-box protein 2 [Homo sapiens]                        54   2e-07
gi|31543297 neutral sphingomyelinase (N-SMase) activation associ...    54   3e-07
gi|221625547 neutral sphingomyelinase (N-SMase) activation assoc...    54   3e-07
gi|18874090 WD repeat domain 48 [Homo sapiens]                         53   5e-07
gi|223005862 echinoderm microtubule associated protein like 6 [H...    52   6e-07
gi|55769546 PAK1 interacting protein 1 [Homo sapiens]                  52   6e-07
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...    50   3e-06
gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo s...    49   5e-06
gi|38327642 WD repeat domain 55 [Homo sapiens]                         49   5e-06

>gi|32699064 WD repeat domain 53 [Homo sapiens]
          Length = 358

 Score =  732 bits (1889), Expect = 0.0
 Identities = 358/358 (100%), Positives = 358/358 (100%)

Query: 1   MAVKWTGGHSSPVLCLNASKEGLLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFS 60
           MAVKWTGGHSSPVLCLNASKEGLLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFS
Sbjct: 1   MAVKWTGGHSSPVLCLNASKEGLLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFS 60

Query: 61  PSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKI 120
           PSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKI
Sbjct: 61  PSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKI 120

Query: 121 LDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQED 180
           LDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQED
Sbjct: 121 LDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQED 180

Query: 181 ETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGH 240
           ETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGH
Sbjct: 181 ETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGH 240

Query: 241 TSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVEKKQKSPTKRTHRKKPKRGTCTKQGG 300
           TSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVEKKQKSPTKRTHRKKPKRGTCTKQGG
Sbjct: 241 TSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVEKKQKSPTKRTHRKKPKRGTCTKQGG 300

Query: 301 NTNASVTDEEEHGNILPKLNIEHGEKVNWLLGTKIKGHQNILVADQTSCISVYPLNEF 358
           NTNASVTDEEEHGNILPKLNIEHGEKVNWLLGTKIKGHQNILVADQTSCISVYPLNEF
Sbjct: 301 NTNASVTDEEEHGNILPKLNIEHGEKVNWLLGTKIKGHQNILVADQTSCISVYPLNEF 358


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 65.5 bits (158), Expect = 7e-11
 Identities = 66/275 (24%), Positives = 107/275 (38%), Gaps = 37/275 (13%)

Query: 8   GHSSPVLCLNASKEG-LLASGAEGGDLTAW-----GEDGTPLGHTRFQGADDVTSVLFSP 61
           GH   V C+N S  G LLASG+    +  W     GE      HT       V SV F  
Sbjct: 21  GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTA-----TVRSVHFCS 75

Query: 62  SCPTKLYASHGETISVLDVRSLKD--SLDHFHVNEEEINCLSLNQTENLLASADDSGAIK 119
              + + AS  +T+ V      K   SL   H+N   + C   +    L+ SA D   +K
Sbjct: 76  DGQSFVTASDDKTVKVWATHRQKFLFSLSQ-HINW--VRCAKFSPDGRLIVSASDDKTVK 132

Query: 120 ILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQE 179
           + D  +++ + S   H    + V F P     + + G+D  V +W ++  R L       
Sbjct: 133 LWDKSSRECVHSYCEHGGFVTYVDFHPSGT-CIAAAGMDNTVKVWDVRTHRLL------- 184

Query: 180 DETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKG 239
                          L+ A  + +S    GN     + D  ++I  +M  +    L   G
Sbjct: 185 -----------QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL--HG 231

Query: 240 HTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEV 274
           H    + V F        +GG+D ++ +W +N ++
Sbjct: 232 HQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDI 266



 Score = 31.2 bits (69), Expect = 1.5
 Identities = 14/39 (35%), Positives = 20/39 (51%)

Query: 237 FKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVE 275
           F GH   V+ V F P  +LL +G  D  + +W  N + E
Sbjct: 19  FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE 57


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 65.5 bits (158), Expect = 7e-11
 Identities = 66/275 (24%), Positives = 107/275 (38%), Gaps = 37/275 (13%)

Query: 8   GHSSPVLCLNASKEG-LLASGAEGGDLTAW-----GEDGTPLGHTRFQGADDVTSVLFSP 61
           GH   V C+N S  G LLASG+    +  W     GE      HT       V SV F  
Sbjct: 59  GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTA-----TVRSVHFCS 113

Query: 62  SCPTKLYASHGETISVLDVRSLKD--SLDHFHVNEEEINCLSLNQTENLLASADDSGAIK 119
              + + AS  +T+ V      K   SL   H+N   + C   +    L+ SA D   +K
Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQ-HINW--VRCAKFSPDGRLIVSASDDKTVK 170

Query: 120 ILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQE 179
           + D  +++ + S   H    + V F P     + + G+D  V +W ++  R L       
Sbjct: 171 LWDKSSRECVHSYCEHGGFVTYVDFHPSGT-CIAAAGMDNTVKVWDVRTHRLL------- 222

Query: 180 DETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKG 239
                          L+ A  + +S    GN     + D  ++I  +M  +    L   G
Sbjct: 223 -----------QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL--HG 269

Query: 240 HTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEV 274
           H    + V F        +GG+D ++ +W +N ++
Sbjct: 270 HQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDI 304



 Score = 37.7 bits (86), Expect = 0.016
 Identities = 36/184 (19%), Positives = 70/184 (38%), Gaps = 21/184 (11%)

Query: 89  HFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQR 148
           HF  + + + C+  +     LAS      + +  ++ +        H +  + V F P  
Sbjct: 14  HFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS- 72

Query: 149 PQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASC 208
              L++ G        S  K   +W+ N++ + T             + A   S+   S 
Sbjct: 73  -GHLLASG--------SRDKTVRIWVPNVKGESTVFR---------AHTATVRSVHFCSD 114

Query: 209 GNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLW 268
           G  F   ++D  V+++     K    L    H + V    F P+  L+++  +D  + LW
Sbjct: 115 GQSFVTASDDKTVKVWATHRQKFLFSL--SQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172

Query: 269 DANS 272
           D +S
Sbjct: 173 DKSS 176



 Score = 31.2 bits (69), Expect = 1.5
 Identities = 14/39 (35%), Positives = 20/39 (51%)

Query: 237 FKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVE 275
           F GH   V+ V F P  +LL +G  D  + +W  N + E
Sbjct: 57  FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE 95


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 65.5 bits (158), Expect = 7e-11
 Identities = 66/275 (24%), Positives = 107/275 (38%), Gaps = 37/275 (13%)

Query: 8   GHSSPVLCLNASKEG-LLASGAEGGDLTAW-----GEDGTPLGHTRFQGADDVTSVLFSP 61
           GH   V C+N S  G LLASG+    +  W     GE      HT       V SV F  
Sbjct: 59  GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTA-----TVRSVHFCS 113

Query: 62  SCPTKLYASHGETISVLDVRSLKD--SLDHFHVNEEEINCLSLNQTENLLASADDSGAIK 119
              + + AS  +T+ V      K   SL   H+N   + C   +    L+ SA D   +K
Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQ-HINW--VRCAKFSPDGRLIVSASDDKTVK 170

Query: 120 ILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQE 179
           + D  +++ + S   H    + V F P     + + G+D  V +W ++  R L       
Sbjct: 171 LWDKSSRECVHSYCEHGGFVTYVDFHPSGT-CIAAAGMDNTVKVWDVRTHRLL------- 222

Query: 180 DETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKG 239
                          L+ A  + +S    GN     + D  ++I  +M  +    L   G
Sbjct: 223 -----------QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL--HG 269

Query: 240 HTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEV 274
           H    + V F        +GG+D ++ +W +N ++
Sbjct: 270 HQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDI 304



 Score = 37.7 bits (86), Expect = 0.016
 Identities = 36/184 (19%), Positives = 70/184 (38%), Gaps = 21/184 (11%)

Query: 89  HFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQR 148
           HF  + + + C+  +     LAS      + +  ++ +        H +  + V F P  
Sbjct: 14  HFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS- 72

Query: 149 PQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASC 208
              L++ G        S  K   +W+ N++ + T             + A   S+   S 
Sbjct: 73  -GHLLASG--------SRDKTVRIWVPNVKGESTVFR---------AHTATVRSVHFCSD 114

Query: 209 GNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLW 268
           G  F   ++D  V+++     K    L    H + V    F P+  L+++  +D  + LW
Sbjct: 115 GQSFVTASDDKTVKVWATHRQKFLFSL--SQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172

Query: 269 DANS 272
           D +S
Sbjct: 173 DKSS 176



 Score = 31.2 bits (69), Expect = 1.5
 Identities = 14/39 (35%), Positives = 20/39 (51%)

Query: 237 FKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVE 275
           F GH   V+ V F P  +LL +G  D  + +W  N + E
Sbjct: 57  FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE 95


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 3/157 (1%)

Query: 9   HSSPVLCLNASKEG-LLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTKL 67
           H+  V C   S +G L+ S +E   +  W        +           V F+PS     
Sbjct: 143 HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIA 202

Query: 68  YASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKK 127
            A   +T+ V DVR  K  L H+ V+   +NC+S + + N L +A   G +KILDL   +
Sbjct: 203 SAGSDQTVKVWDVRVNK-LLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGR 261

Query: 128 VIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLW 164
           +I +L+ H+    +V+F  +  +   S G D QV+LW
Sbjct: 262 LIYTLQGHTGPVFTVSF-SKGGELFASGGADTQVLLW 297



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 71/307 (23%), Positives = 119/307 (38%), Gaps = 32/307 (10%)

Query: 8   GHSSPVLCLNASKEGL-LASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTK 66
           GH + +  L+ S  G  LA+ +    L  W        +      D VTSV FSP     
Sbjct: 16  GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75

Query: 67  LYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENK 126
             AS   T+  L +   +     F  +   +  +  +     LA+A +  +IK+  +  +
Sbjct: 76  ASASRDRTVR-LWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQ 134

Query: 127 KVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPL-------------- 172
           + + SL RH++      F P   + +VSC  D  + +W     + +              
Sbjct: 135 RFLYSLYRHTHWVRCAKFSPDG-RLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD 193

Query: 173 ------WITNLQEDETEEMEGPQSPGQLLNPALAHS-----ISVASCGNIFSCGAEDGKV 221
                  I +   D+T ++   +   +LL     HS     IS    GN     + DG +
Sbjct: 194 FNPSGTCIASAGSDQTVKVWDVRV-NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTL 252

Query: 222 RIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVEKKQKSP 281
           +I  ++  +    L  +GHT  V  V F     L  +GG D ++ LW  N + E   K  
Sbjct: 253 KILDLLEGRLIYTL--QGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFD-ELHCKGL 309

Query: 282 TKRTHRK 288
           TKR  ++
Sbjct: 310 TKRNLKR 316


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 60/231 (25%), Positives = 94/231 (40%), Gaps = 43/231 (18%)

Query: 40  GTPLGHTRFQGADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINC 99
           G   G     G DD    L+S + P  + +  G T  V  VR                  
Sbjct: 29  GKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVR------------------ 70

Query: 100 LSLNQTENLLASADDSGAIKILDLENKKVIRSLKRH-SNICSSVAFRPQRPQSLVSCGLD 158
             LN  E L+ +   SG+I++ DLE  K++R+L  H +NIC S+ F P   + + S   D
Sbjct: 71  --LNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANIC-SLDFHPY-GEFVASGSQD 126

Query: 159 MQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAED 218
             + LW +++   ++             G        +      +  +  G   +  A+D
Sbjct: 127 TNIKLWDIRRKGCVF----------RYRG--------HSQAVRCLRFSPDGKWLASAADD 168

Query: 219 GKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWD 269
             V+++ +   K   E  F GHT  V+ V F P  YLL +G +D  I  WD
Sbjct: 169 HTVKLWDLTAGKMMSE--FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 42/163 (25%), Positives = 71/163 (43%), Gaps = 5/163 (3%)

Query: 8   GHSSPV--LCLNASKEGLLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPT 65
           GH+SPV  + LN  +E L+ +G++ G +  W  +   +  T      ++ S+ F P    
Sbjct: 61  GHTSPVESVRLNTPEE-LIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEF 119

Query: 66  KLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLEN 125
               S    I + D+R  K  +  +  + + + CL  +     LASA D   +K+ DL  
Sbjct: 120 VASGSQDTNIKLWDIRR-KGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTA 178

Query: 126 KKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQK 168
            K++     H+   + V F P     L S   D  +  W L+K
Sbjct: 179 GKMMSEFPGHTGPVNVVEFHPNE-YLLASGSSDRTIRFWDLEK 220



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 40/172 (23%), Positives = 71/172 (41%), Gaps = 6/172 (3%)

Query: 8   GHSSPVLCLNASKEG-LLASGAEGGDLTAWGEDGTPLGHT-RFQGADDVTSVL-FSPSCP 64
           GH + +  L+    G  +ASG++  ++  W  D    G   R++G       L FSP   
Sbjct: 103 GHKANICSLDFHPYGEFVASGSQDTNIKLW--DIRRKGCVFRYRGHSQAVRCLRFSPDGK 160

Query: 65  TKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLE 124
               A+   T+ + D+ + K  +  F  +   +N +  +  E LLAS      I+  DLE
Sbjct: 161 WLASAADDHTVKLWDLTAGK-MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLE 219

Query: 125 NKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITN 176
             +V+  ++       SV F P        C   ++V  W  ++   + + N
Sbjct: 220 KFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVN 271



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 23/81 (28%), Positives = 37/81 (45%), Gaps = 8/81 (9%)

Query: 195 LNPALAHSISVASC------GNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVC 248
           L   +AH+ +V+S       G + + G +D +V ++ +    C   L   GHTS V  V 
Sbjct: 13  LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSL--TGHTSPVESVR 70

Query: 249 FLPESYLLLTGGNDGKITLWD 269
                 L++ G   G I +WD
Sbjct: 71  LNTPEELIVAGSQSGSIRVWD 91


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 49/185 (26%), Positives = 79/185 (42%), Gaps = 21/185 (11%)

Query: 90  FHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRP 149
           F ++E  ++C+S+   +++L S  +    K+L L    V+ +   H++  S   F P   
Sbjct: 348 FRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGD 407

Query: 150 QSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCG 209
           +   S G D  V LW L K           D     EG        +     S +  SCG
Sbjct: 408 KLATSSG-DTTVKLWDLCKG----------DCILTFEG--------HSRAVWSCTWHSCG 448

Query: 210 NIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWD 269
           N  +  + D   +I+ V   +C   L   GHT  V+ + F P S  LLT   D  +++WD
Sbjct: 449 NFVASSSLDKTSKIWDVNSERCRCTL--YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 506

Query: 270 ANSEV 274
           A + +
Sbjct: 507 ARTGI 511



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 36/174 (20%), Positives = 68/174 (39%), Gaps = 22/174 (12%)

Query: 95  EEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVS 154
           + +N +      N L ++     + I D       +SL  H +  +   F P R   + S
Sbjct: 479 DSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP-RGHMIAS 537

Query: 155 CGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIFSC 214
           C       LW  +K  P+   ++         GP SPG        + ++  S G + + 
Sbjct: 538 CDACGVTKLWDFRKLLPIVSIDI---------GP-SPG--------NEVNFDSSGRVLAQ 579

Query: 215 GAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLW 268
            + +G   +  ++ +K  +     GH +    V F  +  +L +GG+DG +  W
Sbjct: 580 ASGNG---VIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630



 Score = 36.2 bits (82), Expect = 0.047
 Identities = 52/219 (23%), Positives = 83/219 (37%), Gaps = 28/219 (12%)

Query: 8   GHSSPVL-CLNASKEGLLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTK 66
           GHS  V  C   S    +AS +       W  +      T +   D V S+ F P   T 
Sbjct: 434 GHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTL 493

Query: 67  LYASHGETISVLDVRS--LKDSL-DHFHVNEEEINCLSLNQTENLLASADDSGAIKILDL 123
           L +S  +T+S+ D R+   + SL  H H     IN    +   +++AS D  G  K+ D 
Sbjct: 494 LTSSADKTLSIWDARTGICEQSLYGHMH----SINDAIFDPRGHMIASCDACGVTKLWDF 549

Query: 124 ENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETE 183
                I S+         +   P    +  S G     +L        + + +L+  E  
Sbjct: 550 RKLLPIVSI--------DIGPSPGNEVNFDSSGR----VLAQASGNGVIHLLDLKSGEIH 597

Query: 184 EMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVR 222
           ++ G ++         AH++  +  G I   G  DG VR
Sbjct: 598 KLMGHENE--------AHTVVFSHDGEILFSGGSDGTVR 628


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 51/208 (24%), Positives = 90/208 (43%), Gaps = 29/208 (13%)

Query: 90  FHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRP 149
           F  +  EI CLS N    L+A+       K+ D++N + + +L+ HS    S++F     
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232

Query: 150 QSLVSCGLDMQVMLWSLQKARPL----------------WITNL----QEDETEEMEGPQ 189
           + +++   D  V++W     R +                W  +L      D+T ++    
Sbjct: 233 R-IITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDAT 291

Query: 190 SPGQLLNPALAHSISVA-SC----GNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGV 244
           + G+ +     H   +  SC    G + +  + DG  RIF     KC  +L  +GH   +
Sbjct: 292 N-GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKL--EGHEGEI 348

Query: 245 SQVCFLPESYLLLTGGNDGKITLWDANS 272
           S++ F P+   LLTG +D    +WDA +
Sbjct: 349 SKISFNPQGNHLLTGSSDKTARIWDAQT 376



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 55/265 (20%), Positives = 100/265 (37%), Gaps = 29/265 (10%)

Query: 8   GHSSPVLCLNASKEG-LLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTK 66
           GH++ ++CL+ + +  L+A+G+       W        +T    + ++ S+ F+ S    
Sbjct: 175 GHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRI 234

Query: 67  LYASHGETISVLDV---RSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDL 123
           +  S   T+ V D    R +   + H      EI+  S N   +L+ +       K+ D 
Sbjct: 235 ITGSFDHTVVVWDADTGRKVNILIGHC----AEISSASFNWDCSLILTGSMDKTCKLWDA 290

Query: 124 ENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETE 183
            N K + +L  H +      F     + + +   D    ++S    +   I  L+  E E
Sbjct: 291 TNGKCVATLTGHDDEILDSCF-DYTGKLIATASADGTARIFSAATRK--CIAKLEGHEGE 347

Query: 184 EMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSG 243
                              IS    GN    G+ D   RI+     +C Q L  +GHT  
Sbjct: 348 ----------------ISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVL--EGHTDE 389

Query: 244 VSQVCFLPESYLLLTGGNDGKITLW 268
           +    F  +  +++TG  D    +W
Sbjct: 390 IFSCAFNYKGNIVITGSKDNTCRIW 414



 Score = 37.7 bits (86), Expect = 0.016
 Identities = 32/124 (25%), Positives = 58/124 (46%), Gaps = 11/124 (8%)

Query: 209 GNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLW 268
           G+  + G+ D   +++ V   KC     F+GHT+ +  + F P+S L+ TG  D    LW
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHT--FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204

Query: 269 DANSEVEKKQKSPTKRTHRKKPKRGTCTKQGGNTNASVTDEEEHGNILPKLNIEHGEKVN 328
           D    ++  ++  T R H  +    +    G   +  +T   +H  ++   + + G KVN
Sbjct: 205 D----IQNGEEVYTLRGHSAEIISLSFNTSG---DRIITGSFDHTVVV--WDADTGRKVN 255

Query: 329 WLLG 332
            L+G
Sbjct: 256 ILIG 259



 Score = 35.4 bits (80), Expect = 0.079
 Identities = 28/173 (16%), Positives = 70/173 (40%), Gaps = 20/173 (11%)

Query: 100 LSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDM 159
           ++LN++ +   +       K+ D  + + + +L+ H N+  ++AF       + +   D 
Sbjct: 98  VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDK 157

Query: 160 QVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDG 219
              LWS++  +     +     T E+                 +S      + + G+ D 
Sbjct: 158 TCKLWSVETGK---CYHTFRGHTAEIV---------------CLSFNPQSTLVATGSMDT 199

Query: 220 KVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANS 272
             +++ +     E+    +GH++ +  + F      ++TG  D  + +WDA++
Sbjct: 200 TAKLWDIQ--NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT 250


>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
           [Homo sapiens]
          Length = 906

 Score = 58.9 bits (141), Expect = 7e-09
 Identities = 42/186 (22%), Positives = 80/186 (43%), Gaps = 23/186 (12%)

Query: 90  FHVNEEEINCLSLNQTENLLASADDSGAIKILDLENK-KVIRSLKRHSNICSSVAFRPQR 148
           F  + + I C++++ T+  + ++ D   IK+ D + K    +  + H++    +   P+ 
Sbjct: 95  FEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKD 154

Query: 149 PQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASC 208
                S  LD  + +W L  + P +           +EG +           + I   S 
Sbjct: 155 NNQFASASLDRTIKVWQLGSSSPNFT----------LEGHEKG--------VNCIDYYSG 196

Query: 209 GN--IFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKIT 266
           G+      GA+D  V+I+      C Q L  +GH   VS   F PE  +++TG  DG + 
Sbjct: 197 GDKPYLISGADDRLVKIWDYQNKTCVQTL--EGHAQNVSCASFHPELPIIITGSEDGTVR 254

Query: 267 LWDANS 272
           +W +++
Sbjct: 255 IWHSST 260


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 65/245 (26%), Positives = 95/245 (38%), Gaps = 54/245 (22%)

Query: 54  VTSVLFSPSCPTKLYASHGETISVLDV------RSLKDSLDHFHVNEEEINCLSLNQTEN 107
           VT V+F P     + AS   TI V D       R+LK   D        +  +S + +  
Sbjct: 111 VTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTD-------SVQDISFDHSGK 163

Query: 108 LLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQ 167
           LLAS      IK+ D +  + IR++  H +  SSVA  P     +VS   D  + +W +Q
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMP-NGDHIVSASRDKTIKMWEVQ 222

Query: 168 KARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVM 227
               +  T     E   M  P   G L          +ASC N       D  VR++ V 
Sbjct: 223 TGYCV-KTFTGHREWVRMVRPNQDGTL----------IASCSN-------DQTVRVWVVA 264

Query: 228 GVKCEQELGFKGHTSGVSQVCFLPESY--------------------LLLTGGNDGKITL 267
             +C+ EL  + H   V  + + PES                      LL+G  D  I +
Sbjct: 265 TKECKAEL--REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKM 322

Query: 268 WDANS 272
           WD ++
Sbjct: 323 WDVST 327



 Score = 28.5 bits (62), Expect = 9.7
 Identities = 15/58 (25%), Positives = 28/58 (48%)

Query: 212 FSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWD 269
           F+ G   G+ R  +    +  ++    GH S V++V F P   ++++   D  I +WD
Sbjct: 79  FTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD 136


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 78/317 (24%), Positives = 130/317 (41%), Gaps = 55/317 (17%)

Query: 41  TPLGHTRFQGADDVTSVLFSPSCPTKLYASHGETISV---LDVRSLKDSLDHFHVNEEEI 97
           T  GHT+      V+SV FSP+      +S  + I +    D +  K    H    +  I
Sbjct: 40  TLAGHTKA-----VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH----KLGI 90

Query: 98  NCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGL 157
           + ++ +   NLL SA D   +KI D+ + K +++LK HSN      F PQ    +VS   
Sbjct: 91  SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ-SNLIVSGSF 149

Query: 158 DMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASC-----GNIF 212
           D  V +W ++                        G+ L    AHS  V++      G++ 
Sbjct: 150 DESVRIWDVK-----------------------TGKCLKTLPAHSDPVSAVHFNRDGSLI 186

Query: 213 SCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANS 272
              + DG  RI+     +C + L        VS V F P    +L    D  + LWD + 
Sbjct: 187 VSSSYDGLCRIWDTASGQCLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245

Query: 273 EVEKKQKSPTKRTHRKKPKRGTCTKQGGNTNASVTDEEEHGNILPKLNIEHGEKVNWLLG 332
              K  K+ T   + K       +  GG    S +++    N++   N++  E V     
Sbjct: 246 --GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED----NLVYIWNLQTKEIVQ---- 295

Query: 333 TKIKGHQNILVADQTSC 349
            K++GH +++++  T+C
Sbjct: 296 -KLQGHTDVVIS--TAC 309


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 78/317 (24%), Positives = 130/317 (41%), Gaps = 55/317 (17%)

Query: 41  TPLGHTRFQGADDVTSVLFSPSCPTKLYASHGETISV---LDVRSLKDSLDHFHVNEEEI 97
           T  GHT+      V+SV FSP+      +S  + I +    D +  K    H    +  I
Sbjct: 40  TLAGHTKA-----VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH----KLGI 90

Query: 98  NCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGL 157
           + ++ +   NLL SA D   +KI D+ + K +++LK HSN      F PQ    +VS   
Sbjct: 91  SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ-SNLIVSGSF 149

Query: 158 DMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASC-----GNIF 212
           D  V +W ++                        G+ L    AHS  V++      G++ 
Sbjct: 150 DESVRIWDVK-----------------------TGKCLKTLPAHSDPVSAVHFNRDGSLI 186

Query: 213 SCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANS 272
              + DG  RI+     +C + L        VS V F P    +L    D  + LWD + 
Sbjct: 187 VSSSYDGLCRIWDTASGQCLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245

Query: 273 EVEKKQKSPTKRTHRKKPKRGTCTKQGGNTNASVTDEEEHGNILPKLNIEHGEKVNWLLG 332
              K  K+ T   + K       +  GG    S +++    N++   N++  E V     
Sbjct: 246 --GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED----NLVYIWNLQTKEIVQ---- 295

Query: 333 TKIKGHQNILVADQTSC 349
            K++GH +++++  T+C
Sbjct: 296 -KLQGHTDVVIS--TAC 309


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 45/192 (23%), Positives = 79/192 (41%), Gaps = 29/192 (15%)

Query: 107 NLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSL 166
           +L ASA     +++ D+   K +R LK H     +V+F P   Q L S G D +VMLW +
Sbjct: 76  HLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ-LASGGWDKRVMLWDV 134

Query: 167 QKARPLWITNLQEDETEEMEGPQSPG----------------QLLNPALAH--------- 201
           Q  + L +     D  +  +   +                  +++ PA++H         
Sbjct: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSAN 194

Query: 202 -SISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGG 260
            S    S   + + G+ D  + I++        +L  KGH + V  + F P+   L + G
Sbjct: 195 ISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQL--KGHVTWVKSIAFSPDELWLASAG 252

Query: 261 NDGKITLWDANS 272
               + +WD N+
Sbjct: 253 YSRMVKVWDCNT 264



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 32/86 (37%), Positives = 44/86 (51%), Gaps = 7/86 (8%)

Query: 192 GQLLNPALAHSISVASC-----GNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQ 246
           GQLL     H+  V  C     G++F+  + D  VR++ V   KC + L  KGH   V  
Sbjct: 53  GQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVL--KGHQRSVET 110

Query: 247 VCFLPESYLLLTGGNDGKITLWDANS 272
           V F P+S  L +GG D ++ LWD  S
Sbjct: 111 VSFSPDSRQLASGGWDKRVMLWDVQS 136



 Score = 32.7 bits (73), Expect = 0.51
 Identities = 29/95 (30%), Positives = 40/95 (42%), Gaps = 16/95 (16%)

Query: 8   GHSSPVLCLNASKEGLLASGAEGGDLTAWGEDGTPL-----GHTRFQGADDVTSVLFSPS 62
           GHS+ + CL  S  GLLASG+    +  W    + L     GH  +     V S+ FSP 
Sbjct: 190 GHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTW-----VKSIAFSPD 244

Query: 63  CPTKLYASHGETISVLD------VRSLKDSLDHFH 91
                 A +   + V D      + +LK  LD  H
Sbjct: 245 ELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAH 279



 Score = 29.6 bits (65), Expect = 4.4
 Identities = 13/36 (36%), Positives = 18/36 (50%)

Query: 237 FKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANS 272
           F  H   V+   F P+  +LLTG  DG +  W+  S
Sbjct: 17  FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRS 52


>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
          Length = 446

 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 59/226 (26%), Positives = 98/226 (43%), Gaps = 35/226 (15%)

Query: 2   AVKWTGGHSSPVLCLNASKEGLLASGAEGGDLTAWGEDGTP-LGHTRFQGADDVTSVLFS 60
           A+ W+   +  +L  +  K   L +  +GG   +W  D  P +GHTR      V  + +S
Sbjct: 219 ALDWSPRVTGRLLTGDCQKNIHLWTPTDGG---SWHVDQRPFVGHTR-----SVEDLQWS 270

Query: 61  PSCPTKLYASHGE-TISVLDVRSLKDS---LDHFHVNEEEINCLSLNQTENLLASADDSG 116
           P+  T   +   + +I + D+R+       L     ++ ++N +S ++ E  L S  D G
Sbjct: 271 PTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGDDG 330

Query: 117 AIKILDLENKK---VIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKAR--- 170
           A+KI DL   K    + + K+H    +SV + PQ      + G D Q+  W L   R   
Sbjct: 331 ALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADHQITQWDLAVERDPE 390

Query: 171 -------------PLWITNLQEDETEEME---GPQSPGQLLNPALA 200
                        P  +  + + ETE  E    PQ PG L++ AL+
Sbjct: 391 AGDVEADPGLADLPQQLLFVHQGETELKELHWHPQCPGLLVSTALS 436



 Score = 28.9 bits (63), Expect = 7.4
 Identities = 19/81 (23%), Positives = 34/81 (41%), Gaps = 8/81 (9%)

Query: 197 PALAHSISVASC------GNIFSCGAEDGKVRIFRVMGV--KCEQELGFKGHTSGVSQVC 248
           P + H+ SV           +F+  + D  +RI+ +     K         H   V+ + 
Sbjct: 256 PFVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVIS 315

Query: 249 FLPESYLLLTGGNDGKITLWD 269
           +      LL+GG+DG + +WD
Sbjct: 316 WSRREPFLLSGGDDGALKIWD 336


>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
           sapiens]
          Length = 513

 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 62/264 (23%), Positives = 107/264 (40%), Gaps = 27/264 (10%)

Query: 13  VLCLNASKEG-LLASGAEGGDLTAWG-EDGTPLGHTRFQGADDVTSVLFSPSCPTKLYAS 70
           VLC+  S++  +LA+GA+ G +  W  + G  L       +  VT + FS      L AS
Sbjct: 267 VLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSAS 326

Query: 71  HGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIR 130
             +TI +  ++S K +L  F  +   +N  +  Q  + + SA   G +KI +++  +   
Sbjct: 327 FDQTIRIHGLKSGK-TLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSN 385

Query: 131 SLKRHSNIC------SSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEE 184
           + K   +        +SV   P+ P+  V C     V++ ++Q         ++   + +
Sbjct: 386 TFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQI------VRSFSSGK 439

Query: 185 MEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGV 244
            EG       L+P           G    C  ED  +  F  +  K E+ L    H   V
Sbjct: 440 REGGDFVCCALSPR----------GEWIYCVGEDFVLYCFSTVTGKLERTLTV--HEKDV 487

Query: 245 SQVCFLPESYLLLTGGNDGKITLW 268
             +   P   L+ T   DG + LW
Sbjct: 488 IGIAHHPHQNLIATYSEDGLLKLW 511



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 44/221 (19%), Positives = 88/221 (39%), Gaps = 31/221 (14%)

Query: 45  HTRFQGADDVTSVLFSPSCPTKLYASHGETISVLDVRSLK-------DSLDHFHVNEEEI 97
           H +F     V    FSP     +  S    I V +  + K        + D+F + ++ +
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267

Query: 98  NCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKR-HSNICSSVAFRPQRPQSLVSCG 156
            C+  ++   +LA+    G IK+  +++ + +R  +R HS   + ++F     Q ++S  
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ-ILSAS 326

Query: 157 LDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGA 216
            D  + +  L+  + L          +E  G  S          +  +    G+     +
Sbjct: 327 FDQTIRIHGLKSGKTL----------KEFRGHSS--------FVNEATFTQDGHYIISAS 368

Query: 217 EDGKVRIFRVMGVKCEQELGFKGHTSG----VSQVCFLPES 253
            DG V+I+ +   +C       G T+G    V+ V  LP++
Sbjct: 369 SDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKN 409



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 37/169 (21%), Positives = 68/169 (40%), Gaps = 10/169 (5%)

Query: 8   GHSSPVLCLNASKEG-LLASGAEGGDLTAWG-------EDGTPLGHTRFQGADD-VTSVL 58
           G  S V C   S +G  L +G+  G +  W        +D        F   DD V  + 
Sbjct: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271

Query: 59  FSPSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAI 118
           FS         +    I V  ++S +        + + + CLS ++  + + SA     I
Sbjct: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331

Query: 119 KILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQ 167
           +I  L++ K ++  + HS+  +   F  Q    ++S   D  V +W+++
Sbjct: 332 RIHGLKSGKTLKEFRGHSSFVNEATF-TQDGHYIISASSDGTVKIWNMK 379



 Score = 33.5 bits (75), Expect = 0.30
 Identities = 13/46 (28%), Positives = 29/46 (63%), Gaps = 1/46 (2%)

Query: 225 RVMGVKCEQELG-FKGHTSGVSQVCFLPESYLLLTGGNDGKITLWD 269
           R+ G+K  + L  F+GH+S V++  F  + + +++  +DG + +W+
Sbjct: 332 RIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377



 Score = 33.1 bits (74), Expect = 0.39
 Identities = 18/70 (25%), Positives = 32/70 (45%), Gaps = 6/70 (8%)

Query: 209 GNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTS------GVSQVCFLPESYLLLTGGND 262
           G     G+ DG + ++     K  ++L ++   +       V  +CF  ++ +L TG  D
Sbjct: 226 GQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQD 285

Query: 263 GKITLWDANS 272
           GKI +W   S
Sbjct: 286 GKIKVWKIQS 295



 Score = 32.7 bits (73), Expect = 0.51
 Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 5/89 (5%)

Query: 211 IFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDA 270
           + + GA+DGK++++++   +C +    + H+ GV+ + F  +S  +L+   D  I +   
Sbjct: 278 MLATGAQDGKIKVWKIQSGQCLRRFE-RAHSKGVTCLSFSKDSSQILSASFDQTIRIHGL 336

Query: 271 NSEVEKKQKSPTKRTHRKKPKRGTCTKQG 299
            S    K+     R H       T T+ G
Sbjct: 337 KSGKTLKE----FRGHSSFVNEATFTQDG 361


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score = 55.5 bits (132), Expect = 7e-08
 Identities = 64/273 (23%), Positives = 108/273 (39%), Gaps = 36/273 (13%)

Query: 12  PVLCLNASKEGL-LASGAEGGDLTAWGEDGTPLGHTRFQGADD--VTSVLFSPSCPTKLY 68
           PV  +  + EG  L +GA  G+ T W  +G          A D  V ++ +S +    L 
Sbjct: 121 PVFVVRWTPEGRRLVTGASSGEFTLW--NGLTFNFETILQAHDSPVRAMTWSHNDMWMLT 178

Query: 69  ASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKV 128
           A HG  +     +S  +++  F  ++E I   S + T+N  A+  D G ++I D      
Sbjct: 179 ADHGGYVKYW--QSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHE 236

Query: 129 IRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGP 188
            R L+ H                    G D++ + W   K   L ++  ++ +       
Sbjct: 237 ERILRGH--------------------GADVKCVDWHPTKG--LVVSGSKDSQQPIKFWD 274

Query: 189 QSPGQLLNPALAHSISVASC-----GNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSG 243
              GQ L    AH  +V        GN     + D   ++F +  +K E ++ F+GH   
Sbjct: 275 PKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQV-FRGHKKE 333

Query: 244 VSQVCFLP-ESYLLLTGGNDGKITLWDANSEVE 275
            + V + P    L  +GG+DG +  W    E E
Sbjct: 334 ATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKE 366


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 74/310 (23%), Positives = 128/310 (41%), Gaps = 49/310 (15%)

Query: 41  TPLGHTRFQGADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCL 100
           T +GHT     + V+SV FSP+      +S    I +      K     +  N E I+ +
Sbjct: 36  TLVGHT-----EAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLE-ISDV 89

Query: 101 SLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCG-LDM 159
           + +   + L SA D   +K+ D+ + K +++LK HSN      F P  P +L+  G  D 
Sbjct: 90  AWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP--PSNLIISGSFDE 147

Query: 160 QVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVAS-----CGNIFSC 214
            V +W ++                        G+ L    AHS  V++      G++   
Sbjct: 148 TVKIWEVK-----------------------TGKCLKTLSAHSDPVSAVHFNCSGSLIVS 184

Query: 215 GAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEV 274
           G+ DG  RI+     +C + L        VS V F P    +LT   D  + LWD +   
Sbjct: 185 GSYDGLCRIWDAASGQCLKTL-VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR-- 241

Query: 275 EKKQKSPTKRTHRKKPKRGTCTKQGGNTNASVTDEEEHGNILPKLNIEHGEKVNWLLGTK 334
            +  K+ T   + K       +  GG    S +++    N++   N++  E V      K
Sbjct: 242 GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED----NLVYIWNLQTKEIVQ-----K 292

Query: 335 IKGHQNILVA 344
           ++GH +++++
Sbjct: 293 LQGHTDVVIS 302


>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
            sapiens]
          Length = 1205

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 25/204 (12%)

Query: 91   HVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQ 150
            ++ E +++C  L+     +A  D++GAI+IL+L N ++ +S  +H      + F     +
Sbjct: 915  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE-K 973

Query: 151  SLVSCGLDMQVMLWSLQKARPLWITNLQEDETE------------EMEGPQSPGQLLN-- 196
            +L+S   D ++ +W+ Q  + +++   QE   +              +G      ++   
Sbjct: 974  TLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGN 1033

Query: 197  ---PALAHSISVASC-----GNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVC 248
                 + H  +V SC        FS  + D   +I+    +    EL  +GH   V    
Sbjct: 1034 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL--RGHNGCVRCSA 1091

Query: 249  FLPESYLLLTGGNDGKITLWDANS 272
            F  +S LL TG ++G+I +W+ ++
Sbjct: 1092 FSVDSTLLATGDDNGEIRIWNVSN 1115



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 54/211 (25%), Positives = 86/211 (40%), Gaps = 27/211 (12%)

Query: 82  SLKDSLDH-FHVNEEEINCLSLNQTEN--LLASADDSGAIKILDLENKKVIRSLKRHSNI 138
           S+   L H +  + E++NC     + +  LLA+      +K+ DL  K+   ++  H+N 
Sbjct: 686 SMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNS 745

Query: 139 CSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPA 198
            +   F P   + L SC  D  + LW    A      N+++     +E PQ   +++   
Sbjct: 746 VNHCRFSPD-DKLLASCSADGTLKLWDATSANERKSINVKQFFLN-LEDPQEDMEVIVKC 803

Query: 199 LAHS-----ISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPES 253
            + S     I VA+   IF    +       R     C      +GH S V  V F P+ 
Sbjct: 804 CSWSADGARIMVAAKNKIFLWNTDS------RSKVADC------RGHLSWVHGVMFSPDG 851

Query: 254 YLLLTGGNDGKITLWDA-----NSEVEKKQK 279
              LT  +D  I LW+      NS V  KQ+
Sbjct: 852 SSFLTSSDDQTIRLWETKKVCKNSAVMLKQE 882



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 47/205 (22%), Positives = 79/205 (38%), Gaps = 34/205 (16%)

Query: 104 QTENLLASADDSGAIKILDLENKKVIRSLKR-----HSNICSSVAFRPQRPQSLVSCGLD 158
           Q   L A  +    +  L+  NKK I +L R     H++      F  +  Q + SCG D
Sbjct: 578 QQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFS-EDGQRIASCGAD 636

Query: 159 MQVMLWSLQKARPLWITNLQEDET-------------------EEMEGPQSPGQLLNPAL 199
             + ++  +    L      EDE                    +        G+L++   
Sbjct: 637 KTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYD 696

Query: 200 AHSISVASCGN-------IFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPE 252
            HS  V  C         + + G+ D  ++++ +   +C   +   GHT+ V+   F P+
Sbjct: 697 EHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF--GHTNSVNHCRFSPD 754

Query: 253 SYLLLTGGNDGKITLWDANSEVEKK 277
             LL +   DG + LWDA S  E+K
Sbjct: 755 DKLLASCSADGTLKLWDATSANERK 779



 Score = 34.3 bits (77), Expect = 0.18
 Identities = 59/296 (19%), Positives = 108/296 (36%), Gaps = 40/296 (13%)

Query: 9   HSSPVLCL---NASKEGLLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPT 65
           HS  V C    N+S   LLA+G+    L  W  +     +T F   + V    FSP    
Sbjct: 698 HSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKL 757

Query: 66  KLYASHGETISVLDVRSLKD----SLDHFHVNEEE--------INCLSLN-QTENLLASA 112
               S   T+ + D  S  +    ++  F +N E+        + C S +     ++ +A
Sbjct: 758 LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA 817

Query: 113 DDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPL 172
            +   I + + +++  +   + H +    V F P     L S   D  + LW  +K    
Sbjct: 818 KNK--IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD-DQTIRLWETKKVCKN 874

Query: 173 WITNLQED------ETEEM-------------EGPQSPGQLLNPALAHSISVASCGNIFS 213
               L+++      E E M              G       L  A      ++      +
Sbjct: 875 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 934

Query: 214 CGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWD 269
            G E+G + I  ++  +  Q   F+ H   V  + F  +   L++  +D +I +W+
Sbjct: 935 FGDENGAIEILELVNNRIFQS-RFQ-HKKTVWHIQFTADEKTLISSSDDAEIQVWN 988


>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
            sapiens]
          Length = 1248

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 25/204 (12%)

Query: 91   HVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQ 150
            ++ E +++C  L+     +A  D++GAI+IL+L N ++ +S  +H      + F     +
Sbjct: 958  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE-K 1016

Query: 151  SLVSCGLDMQVMLWSLQKARPLWITNLQEDETE------------EMEGPQSPGQLLN-- 196
            +L+S   D ++ +W+ Q  + +++   QE   +              +G      ++   
Sbjct: 1017 TLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGN 1076

Query: 197  ---PALAHSISVASC-----GNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVC 248
                 + H  +V SC        FS  + D   +I+    +    EL  +GH   V    
Sbjct: 1077 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL--RGHNGCVRCSA 1134

Query: 249  FLPESYLLLTGGNDGKITLWDANS 272
            F  +S LL TG ++G+I +W+ ++
Sbjct: 1135 FSVDSTLLATGDDNGEIRIWNVSN 1158



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 47/205 (22%), Positives = 79/205 (38%), Gaps = 34/205 (16%)

Query: 104 QTENLLASADDSGAIKILDLENKKVIRSLKR-----HSNICSSVAFRPQRPQSLVSCGLD 158
           Q   L A  +    +  L+  NKK I +L R     H++      F  +  Q + SCG D
Sbjct: 578 QQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFS-EDGQRIASCGAD 636

Query: 159 MQVMLWSLQKARPLWITNLQEDET-------------------EEMEGPQSPGQLLNPAL 199
             + ++  +    L      EDE                    +        G+L++   
Sbjct: 637 KTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYD 696

Query: 200 AHSISVASCGN-------IFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPE 252
            HS  V  C         + + G+ D  ++++ +   +C   +   GHT+ V+   F P+
Sbjct: 697 EHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF--GHTNSVNHCRFSPD 754

Query: 253 SYLLLTGGNDGKITLWDANSEVEKK 277
             LL +   DG + LWDA S  E+K
Sbjct: 755 DKLLASCSADGTLKLWDATSANERK 779



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 43/194 (22%), Positives = 81/194 (41%), Gaps = 11/194 (5%)

Query: 82  SLKDSLDH-FHVNEEEINCLSLNQTEN--LLASADDSGAIKILDLENKKVIRSLKRHSNI 138
           S+   L H +  + E++NC     + +  LLA+      +K+ DL  K+   ++  H+N 
Sbjct: 686 SMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNS 745

Query: 139 CSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPA 198
            +   F P   + L SC  D  + LW    A      N+++     +E PQ   +++   
Sbjct: 746 VNHCRFSPD-DKLLASCSADGTLKLWDATSANERKSINVKQFFL-NLEDPQEDMEVIVKC 803

Query: 199 LAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLT 258
            + S   A         A   K+ +F +       E+   GH S +    F P+++L + 
Sbjct: 804 CSWSADGARI-----MVAAKNKIFLFDIHTSGLLGEI-HTGHHSTIQYCDFSPQNHLAVV 857

Query: 259 GGNDGKITLWDANS 272
             +   + LW+ +S
Sbjct: 858 ALSQYCVELWNTDS 871


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
            sapiens]
          Length = 1194

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 25/204 (12%)

Query: 91   HVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQ 150
            ++ E +++C  L+     +A  D++GAI+IL+L N ++ +S  +H      + F     +
Sbjct: 904  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE-K 962

Query: 151  SLVSCGLDMQVMLWSLQKARPLWITNLQEDETE------------EMEGPQSPGQLLN-- 196
            +L+S   D ++ +W+ Q  + +++   QE   +              +G      ++   
Sbjct: 963  TLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGN 1022

Query: 197  ---PALAHSISVASC-----GNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVC 248
                 + H  +V SC        FS  + D   +I+    +    EL  +GH   V    
Sbjct: 1023 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL--RGHNGCVRCSA 1080

Query: 249  FLPESYLLLTGGNDGKITLWDANS 272
            F  +S LL TG ++G+I +W+ ++
Sbjct: 1081 FSVDSTLLATGDDNGEIRIWNVSN 1104



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 54/211 (25%), Positives = 86/211 (40%), Gaps = 27/211 (12%)

Query: 82  SLKDSLDH-FHVNEEEINCLSLNQTEN--LLASADDSGAIKILDLENKKVIRSLKRHSNI 138
           S+   L H +  + E++NC     + +  LLA+      +K+ DL  K+   ++  H+N 
Sbjct: 675 SMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNS 734

Query: 139 CSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPA 198
            +   F P   + L SC  D  + LW    A      N+++     +E PQ   +++   
Sbjct: 735 VNHCRFSPD-DKLLASCSADGTLKLWDATSANERKSINVKQFFLN-LEDPQEDMEVIVKC 792

Query: 199 LAHS-----ISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPES 253
            + S     I VA+   IF    +       R     C      +GH S V  V F P+ 
Sbjct: 793 CSWSADGARIMVAAKNKIFLWNTDS------RSKVADC------RGHLSWVHGVMFSPDG 840

Query: 254 YLLLTGGNDGKITLWDA-----NSEVEKKQK 279
              LT  +D  I LW+      NS V  KQ+
Sbjct: 841 SSFLTSSDDQTIRLWETKKVCKNSAVMLKQE 871



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 47/205 (22%), Positives = 79/205 (38%), Gaps = 34/205 (16%)

Query: 104 QTENLLASADDSGAIKILDLENKKVIRSLKR-----HSNICSSVAFRPQRPQSLVSCGLD 158
           Q   L A  +    +  L+  NKK I +L R     H++      F  +  Q + SCG D
Sbjct: 567 QQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFS-EDGQRIASCGAD 625

Query: 159 MQVMLWSLQKARPLWITNLQEDET-------------------EEMEGPQSPGQLLNPAL 199
             + ++  +    L      EDE                    +        G+L++   
Sbjct: 626 KTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYD 685

Query: 200 AHSISVASCGN-------IFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPE 252
            HS  V  C         + + G+ D  ++++ +   +C   +   GHT+ V+   F P+
Sbjct: 686 EHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF--GHTNSVNHCRFSPD 743

Query: 253 SYLLLTGGNDGKITLWDANSEVEKK 277
             LL +   DG + LWDA S  E+K
Sbjct: 744 DKLLASCSADGTLKLWDATSANERK 768



 Score = 34.3 bits (77), Expect = 0.18
 Identities = 59/296 (19%), Positives = 108/296 (36%), Gaps = 40/296 (13%)

Query: 9   HSSPVLCL---NASKEGLLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPT 65
           HS  V C    N+S   LLA+G+    L  W  +     +T F   + V    FSP    
Sbjct: 687 HSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKL 746

Query: 66  KLYASHGETISVLDVRSLKD----SLDHFHVNEEE--------INCLSLN-QTENLLASA 112
               S   T+ + D  S  +    ++  F +N E+        + C S +     ++ +A
Sbjct: 747 LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA 806

Query: 113 DDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPL 172
            +   I + + +++  +   + H +    V F P     L S   D  + LW  +K    
Sbjct: 807 KNK--IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD-DQTIRLWETKKVCKN 863

Query: 173 WITNLQED------ETEEM-------------EGPQSPGQLLNPALAHSISVASCGNIFS 213
               L+++      E E M              G       L  A      ++      +
Sbjct: 864 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 923

Query: 214 CGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWD 269
            G E+G + I  ++  +  Q   F+ H   V  + F  +   L++  +D +I +W+
Sbjct: 924 FGDENGAIEILELVNNRIFQS-RFQ-HKKTVWHIQFTADEKTLISSSDDAEIQVWN 977


>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
            sapiens]
          Length = 1237

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 25/204 (12%)

Query: 91   HVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQ 150
            ++ E +++C  L+     +A  D++GAI+IL+L N ++ +S  +H      + F     +
Sbjct: 947  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE-K 1005

Query: 151  SLVSCGLDMQVMLWSLQKARPLWITNLQEDETE------------EMEGPQSPGQLLN-- 196
            +L+S   D ++ +W+ Q  + +++   QE   +              +G      ++   
Sbjct: 1006 TLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGN 1065

Query: 197  ---PALAHSISVASC-----GNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVC 248
                 + H  +V SC        FS  + D   +I+    +    EL  +GH   V    
Sbjct: 1066 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL--RGHNGCVRCSA 1123

Query: 249  FLPESYLLLTGGNDGKITLWDANS 272
            F  +S LL TG ++G+I +W+ ++
Sbjct: 1124 FSVDSTLLATGDDNGEIRIWNVSN 1147



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 47/205 (22%), Positives = 79/205 (38%), Gaps = 34/205 (16%)

Query: 104 QTENLLASADDSGAIKILDLENKKVIRSLKR-----HSNICSSVAFRPQRPQSLVSCGLD 158
           Q   L A  +    +  L+  NKK I +L R     H++      F  +  Q + SCG D
Sbjct: 567 QQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFS-EDGQRIASCGAD 625

Query: 159 MQVMLWSLQKARPLWITNLQEDET-------------------EEMEGPQSPGQLLNPAL 199
             + ++  +    L      EDE                    +        G+L++   
Sbjct: 626 KTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYD 685

Query: 200 AHSISVASCGN-------IFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPE 252
            HS  V  C         + + G+ D  ++++ +   +C   +   GHT+ V+   F P+
Sbjct: 686 EHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF--GHTNSVNHCRFSPD 743

Query: 253 SYLLLTGGNDGKITLWDANSEVEKK 277
             LL +   DG + LWDA S  E+K
Sbjct: 744 DKLLASCSADGTLKLWDATSANERK 768



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 43/194 (22%), Positives = 81/194 (41%), Gaps = 11/194 (5%)

Query: 82  SLKDSLDH-FHVNEEEINCLSLNQTEN--LLASADDSGAIKILDLENKKVIRSLKRHSNI 138
           S+   L H +  + E++NC     + +  LLA+      +K+ DL  K+   ++  H+N 
Sbjct: 675 SMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNS 734

Query: 139 CSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPA 198
            +   F P   + L SC  D  + LW    A      N+++     +E PQ   +++   
Sbjct: 735 VNHCRFSPD-DKLLASCSADGTLKLWDATSANERKSINVKQFFL-NLEDPQEDMEVIVKC 792

Query: 199 LAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLT 258
            + S   A         A   K+ +F +       E+   GH S +    F P+++L + 
Sbjct: 793 CSWSADGARI-----MVAAKNKIFLFDIHTSGLLGEI-HTGHHSTIQYCDFSPQNHLAVV 846

Query: 259 GGNDGKITLWDANS 272
             +   + LW+ +S
Sbjct: 847 ALSQYCVELWNTDS 860


>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
          Length = 404

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 57/250 (22%), Positives = 105/250 (42%), Gaps = 14/250 (5%)

Query: 23  LLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVL-FSPSCPTKLY-ASHGETISVLDV 80
           +LA+G   G +  W E  T L      G  DV   L F+PS    L  AS  +T+ + D+
Sbjct: 125 VLATGLNDGQIKIW-EVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDL 183

Query: 81  RSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICS 140
                 +     + + + C S++   ++L SA    ++ +  + +  +IR L+ H +   
Sbjct: 184 NKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVV 243

Query: 141 SVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALA 200
           S  F P     LV+   D  V++W       L   +L   + +    P      ++ +  
Sbjct: 244 SCDFSPDSAL-LVTASYDTNVIMWDPYTGERL--RSLHHTQVD----PAMDDSDVHISSL 296

Query: 201 HSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGG 260
            S+  +  G   +  A+D   R+ R+  ++ +  + F   T+G+    F P   ++ TG 
Sbjct: 297 RSVCFSPEGLYLATVADD---RLLRIWALELKTPIAFAPMTNGLC-CTFFPHGGVIATGT 352

Query: 261 NDGKITLWDA 270
            DG +  W A
Sbjct: 353 RDGHVQFWTA 362



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 64/273 (23%), Positives = 109/273 (39%), Gaps = 56/273 (20%)

Query: 5   WTGGHSSPVLCLNASKEGLLASGAEGGDLTAWGED---GTPLGHTRFQGADDVTSVLFSP 61
           W+ GH    L     +E  +  G E    ++  E    G+P   T   G   V  + FSP
Sbjct: 43  WSQGHCIVKLIPWPLEEQFIPKGFEAKSRSSKNETKGRGSPKEKTLDCG-QIVWGLAFSP 101

Query: 62  --SCPT-KLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAI 118
             S P+ KL+A H                   H    +++CL       +LA+  + G I
Sbjct: 102 WPSPPSRKLWARH-------------------HPQVPDVSCL-------VLATGLNDGQI 135

Query: 119 KILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQ 178
           KI +++   ++ +L  H ++   ++F P     LVS   D  + +W L K          
Sbjct: 136 KIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK---------- 185

Query: 179 EDETEEMEGPQSPGQLLNPAL--AHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELG 236
                   G Q   Q+L+  L   +  S++   ++    A +  V ++ +      ++L 
Sbjct: 186 -------HGKQI--QVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKL- 235

Query: 237 FKGHTSGVSQVCFLPESYLLLTGGNDGKITLWD 269
            +GH S V    F P+S LL+T   D  + +WD
Sbjct: 236 -EGHQSSVVSCDFSPDSALLVTASYDTNVIMWD 267


>gi|31543297 neutral sphingomyelinase (N-SMase) activation
           associated factor isoform 1 [Homo sapiens]
          Length = 917

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 39/176 (22%), Positives = 76/176 (43%), Gaps = 24/176 (13%)

Query: 93  NEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSL 152
           ++  ++ +SLN    LL S    G + I DL    ++  +  HS I    AF P   + +
Sbjct: 762 HDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPD-SRHV 820

Query: 153 VSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIF 212
           +S G D  + +  +Q    + I+++  DE +                         GN  
Sbjct: 821 LSTGTDGCLNVIDVQTG--MLISSMTSDEPQR-------------------CFVWDGNSV 859

Query: 213 SCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLW 268
             G++ G++ ++ ++G K  + +  +GHT  V+ +    +   ++TGG D +I  W
Sbjct: 860 LSGSQSGELLVWDLLGAKISERI--QGHTGAVTCIWMNEQCSSIITGGEDRQIIFW 913



 Score = 30.4 bits (67), Expect = 2.6
 Identities = 40/216 (18%), Positives = 83/216 (38%), Gaps = 34/216 (15%)

Query: 88  DHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQ 147
           +H+ +++E +  +++++  + + +      +K+   E+K + RS+   +   SS    P 
Sbjct: 624 EHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPG 683

Query: 148 RPQSLVSCGLDMQVMLWSLQKARP--------------LWITN----LQEDET------- 182
              ++++   D  V  +S+   R                W  N       D T       
Sbjct: 684 -DATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGV 742

Query: 183 -EEMEGPQSPGQLLNPALAHSISVAS-----CGNIFSCGAEDGKVRIFRVMGVKCEQELG 236
             EM G +     L   L H +SV +        +   G ++G V I+ +       ++ 
Sbjct: 743 PAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIP 802

Query: 237 FKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANS 272
              H+  V    F P+S  +L+ G DG + + D  +
Sbjct: 803 C--HSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQT 836


>gi|221625547 neutral sphingomyelinase (N-SMase) activation
           associated factor isoform 2 [Homo sapiens]
          Length = 948

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 39/176 (22%), Positives = 76/176 (43%), Gaps = 24/176 (13%)

Query: 93  NEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSL 152
           ++  ++ +SLN    LL S    G + I DL    ++  +  HS I    AF P   + +
Sbjct: 793 HDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPD-SRHV 851

Query: 153 VSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIF 212
           +S G D  + +  +Q    + I+++  DE +                         GN  
Sbjct: 852 LSTGTDGCLNVIDVQTG--MLISSMTSDEPQR-------------------CFVWDGNSV 890

Query: 213 SCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLW 268
             G++ G++ ++ ++G K  + +  +GHT  V+ +    +   ++TGG D +I  W
Sbjct: 891 LSGSQSGELLVWDLLGAKISERI--QGHTGAVTCIWMNEQCSSIITGGEDRQIIFW 944



 Score = 30.4 bits (67), Expect = 2.6
 Identities = 40/216 (18%), Positives = 83/216 (38%), Gaps = 34/216 (15%)

Query: 88  DHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQ 147
           +H+ +++E +  +++++  + + +      +K+   E+K + RS+   +   SS    P 
Sbjct: 655 EHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPG 714

Query: 148 RPQSLVSCGLDMQVMLWSLQKARP--------------LWITN----LQEDET------- 182
              ++++   D  V  +S+   R                W  N       D T       
Sbjct: 715 -DATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGV 773

Query: 183 -EEMEGPQSPGQLLNPALAHSISVAS-----CGNIFSCGAEDGKVRIFRVMGVKCEQELG 236
             EM G +     L   L H +SV +        +   G ++G V I+ +       ++ 
Sbjct: 774 PAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIP 833

Query: 237 FKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANS 272
              H+  V    F P+S  +L+ G DG + + D  +
Sbjct: 834 C--HSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQT 867


>gi|18874090 WD repeat domain 48 [Homo sapiens]
          Length = 677

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 41/188 (21%), Positives = 80/188 (42%), Gaps = 15/188 (7%)

Query: 86  SLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFR 145
           S++H   + + +N + L      L SA     +K+ +      + +L+ H +   ++A+ 
Sbjct: 70  SMEH---HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYA 126

Query: 146 PQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISV 205
             + + + S GLD Q+ LW +     L  +N     T  + G        N    +S+++
Sbjct: 127 KDK-ELVASAGLDRQIFLWDVNTLTALTASN-NTVTTSSLSG--------NKDSIYSLAM 176

Query: 206 ASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKI 265
              G I   G+ +  +R++      C + +  KGHT  V  +    +    L+G +DG I
Sbjct: 177 NQLGTIIVSGSTEKVLRVWDPR--TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTI 234

Query: 266 TLWDANSE 273
            LW    +
Sbjct: 235 RLWSLGQQ 242


>gi|223005862 echinoderm microtubule associated protein like 6 [Homo
           sapiens]
          Length = 1958

 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 63/276 (22%), Positives = 111/276 (40%), Gaps = 34/276 (12%)

Query: 8   GHSSPVLCLNASKEGLLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTKL 67
           G    +LCL  +KE +  SGA  GD+  W   G  L  T  QGA   ++ +FS     + 
Sbjct: 195 GDLQTILCLACAKEDITYSGALNGDIYVW--KGLNLVRT-IQGAH--SAGIFSMYACEEG 249

Query: 68  YASHGE--TISVLDVRSLKDSLDHFHVNEEEINCLSLN----QTENLLASADDSGAIKIL 121
           +A+ G    I + D      +       E+    LS+     + + LLA   DS   +++
Sbjct: 250 FATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVI 309

Query: 122 DLENKKVIRSLKRH-SNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQED 180
             E  K +  L+ H      ++A  P++P ++     D  V LWSL     +   N++E 
Sbjct: 310 VRERDKPMLILQGHCEGELWALALHPKKPLAVTGSD-DRSVRLWSLADHALIARCNMEE- 367

Query: 181 ETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGH 240
                                S++ +  G+  + G +DG   + RV  +   + +  K  
Sbjct: 368 ------------------AVRSVAFSPDGSQLALGMKDGSFIVLRVRDM--TEVVHIKDR 407

Query: 241 TSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVEK 276
              + ++ F P+   L  G NDG + ++      +K
Sbjct: 408 KEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKK 443



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 61/269 (22%), Positives = 108/269 (40%), Gaps = 48/269 (17%)

Query: 43  LGHTRFQGADDVTSVLFSPS--------CPTKLYASHGETISVLDVRSLKDSLDHFHVNE 94
           LGH      DD+ S+   P            + Y    ++ +V  V  LKD      V+ 
Sbjct: 58  LGHN-----DDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKD------VHT 106

Query: 95  EEINCLSLNQTENLLASA--DDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSL 152
             + CL+ +     LAS   D    + I D    K++ S   HS+    +++ P +P  +
Sbjct: 107 HGVACLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRV 166

Query: 153 VSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCG--N 210
           VSCG+   +  W+L     L        +T +++               +I   +C   +
Sbjct: 167 VSCGV-KHIKFWTL-CGNALTAKRGIFGKTGDLQ---------------TILCLACAKED 209

Query: 211 IFSCGAEDGKVRIFRVMG-VKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWD 269
           I   GA +G + +++ +  V+  Q      H++G+  +    E +   TGG DG I LWD
Sbjct: 210 ITYSGALNGDIYVWKGLNLVRTIQ----GAHSAGIFSMYACEEGF--ATGGRDGCIRLWD 263

Query: 270 AN-SEVEKKQKSPTKRTHRKKPKRGTCTK 297
            +   + K     T++ ++    R  C K
Sbjct: 264 TDFKPITKIDLRETEQGYKGLSIRSVCWK 292



 Score = 30.8 bits (68), Expect = 2.0
 Identities = 21/78 (26%), Positives = 36/78 (46%), Gaps = 3/78 (3%)

Query: 91   HVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKR---HSNICSSVAFRPQ 147
            H +  ++N  SL +  +LLA+ DD G +K+     K      K+   HS   ++V +   
Sbjct: 1190 HSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHN 1249

Query: 148  RPQSLVSCGLDMQVMLWS 165
                L   G D  +M+W+
Sbjct: 1250 DSVLLTVGGADTALMIWT 1267



 Score = 29.6 bits (65), Expect = 4.4
 Identities = 44/208 (21%), Positives = 82/208 (39%), Gaps = 35/208 (16%)

Query: 93  NEEEINCLSLNQTENLLASAD--DSGAIKILDLENKKVIRSLK-RHSNICSSVAFRPQRP 149
           ++++I  L+++  ++ +A+       AI + D +  K +  LK +H     ++ F     
Sbjct: 726 HDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADG- 784

Query: 150 QSLVSCGLD--MQVMLWSLQKARPLWITNLQEDETEEME-GPQSPGQLLNPALAHSISVA 206
           + LVS GLD    ++ W  +K   +  T   +D+   ++  P    +L+   + H     
Sbjct: 785 KCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQ 844

Query: 207 SCGNIFSCG----AEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLL----- 257
             G  F+         GK+     +     ++L F G  +G     F+ +  LLL     
Sbjct: 845 QAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGD---IFIWKDILLLKTVKA 901

Query: 258 ----------------TGGNDGKITLWD 269
                           TGG DG + LWD
Sbjct: 902 HDGPVFAMYALDKGFVTGGKDGIVELWD 929


>gi|55769546 PAK1 interacting protein 1 [Homo sapiens]
          Length = 392

 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 48/224 (21%), Positives = 98/224 (43%), Gaps = 33/224 (14%)

Query: 70  SHGETISVLDVRSLKDSLDHFHV--NEEEINCLSLNQTENLLASADDSGAIKILDLENKK 127
           S  ETI + D   +K  ++H  +  +   I CL      +L++ A+D G I I D +  +
Sbjct: 59  SKDETIHIYD---MKKKIEHGALVHHSGTITCLKFYGNRHLISGAED-GLICIWDAKKWE 114

Query: 128 VIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQED------- 180
            ++S+K H    + ++  P    +L S G D  +  W+L + R  +I N++++       
Sbjct: 115 CLKSIKAHKGQVTFLSIHPSGKLAL-SVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWS 173

Query: 181 --------------ETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRV 226
                         +  +++     G + N     S+   S  ++ +   ++  +R F  
Sbjct: 174 PRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISSVKFLS-ESVLAVAGDEEVIRFFDC 232

Query: 227 MGVKCEQELGFKGHTSGVSQVCF--LPESYLLLTGGNDGKITLW 268
             + C  E  FK H + V  +    +PE +++++  +DG I +W
Sbjct: 233 DSLVCLCE--FKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMW 274


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 41/151 (27%), Positives = 60/151 (39%), Gaps = 22/151 (14%)

Query: 125 NKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEE 184
           N +V R L  H+   S   F     Q + S G D    LW ++                 
Sbjct: 132 NVRVSRELPGHTGYLSCCRFLDDN-QIITSSG-DTTCALWDIET---------------- 173

Query: 185 MEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGV 244
             G Q+ G   +     S+S+A  G  F  GA D  ++++ V    C Q   F GH S +
Sbjct: 174 --GQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQT--FIGHESDI 229

Query: 245 SQVCFLPESYLLLTGGNDGKITLWDANSEVE 275
           + V F P  Y   TG +D    L+D  ++ E
Sbjct: 230 NAVAFFPNGYAFTTGSDDATCRLFDLRADQE 260



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 56/273 (20%), Positives = 109/273 (39%), Gaps = 36/273 (13%)

Query: 8   GHSSPVLCLNASKEG-LLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTK 66
           GH + +  ++   +  LL S ++ G L  W    T   H     +  V +  ++PS    
Sbjct: 53  GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN-- 110

Query: 67  LYASHGETISVLDVRSLKDSLDHFHVNEE------EINCLSLNQTENLLASADDSGAIKI 120
            + + G   ++  + SLK    +  V+ E       ++C        ++ S+ D+    +
Sbjct: 111 -FVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDT-TCAL 168

Query: 121 LDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQED 180
            D+E  +       HS    S++  P   ++ VS   D  + LW ++ +           
Sbjct: 169 WDIETGQQTVGFAGHSGDVMSLSLAPDG-RTFVSGACDASIKLWDVRDSMC--------- 218

Query: 181 ETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGH 240
             +   G +S          ++++    G  F+ G++D   R+F    ++ +QEL    H
Sbjct: 219 -RQTFIGHESD--------INAVAFFPNGYAFTTGSDDATCRLF---DLRADQELLMYSH 266

Query: 241 TS---GVSQVCFLPESYLLLTGGNDGKITLWDA 270
            +   G++ V F     LLL G +D    +WDA
Sbjct: 267 DNIICGITSVAFSRSGRLLLAGYDDFNCNIWDA 299


>gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo
           sapiens]
          Length = 475

 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 41/176 (23%), Positives = 78/176 (44%), Gaps = 23/176 (13%)

Query: 93  NEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSL 152
           +   + C++++     LAS D S  I I + ++ + + +   H +  S +AFR +    L
Sbjct: 198 HSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFR-RGTHQL 256

Query: 153 VSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIF 212
            S   D  V +W++           +    E + G Q     L+ AL+    V       
Sbjct: 257 YSTSHDRSVKVWNV----------AENSYVETLFGHQDAVAALD-ALSRECCV------- 298

Query: 213 SCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLW 268
           + G  DG VR++++     E +L F GH   +  +  + E + +++G +DG + LW
Sbjct: 299 TAGGRDGTVRVWKIPE---ESQLVFYGHQGSIDCIHLINEEH-MVSGADDGSVALW 350



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 66/271 (24%), Positives = 109/271 (40%), Gaps = 28/271 (10%)

Query: 8   GHSSPVLCLNASKEG-LLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTK 66
           GHSS VLC+  S +G  LASG     +  W        +T F G  D  S L       +
Sbjct: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYT-FTGHRDAVSGLAFRRGTHQ 255

Query: 67  LYA-SHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLEN 125
           LY+ SH  ++ V +V      ++    +++ +  L     E  + +    G +++  +  
Sbjct: 256 LYSTSHDRSVKVWNVAE-NSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE 314

Query: 126 KKVIRSLKRHSNI-CSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEE 184
           +  +       +I C  +       + +VS   D  V LW L K RPL +         E
Sbjct: 315 ESQLVFYGHQGSIDCIHLI----NEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGE 370

Query: 185 --MEGP---QSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQEL-GFK 238
             +E P    S   LLN  L  + S +SC  ++ CG        FR + + C+  L GF 
Sbjct: 371 PGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEG------FRQLDLLCDIPLVGF- 423

Query: 239 GHTSGVSQVCFLPESYLLLTG-GNDGKITLW 268
                ++ + F      L+ G G + ++  W
Sbjct: 424 -----INSLKFSSSGDFLVAGVGQEHRLGRW 449



 Score = 35.0 bits (79), Expect = 0.10
 Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 12/149 (8%)

Query: 129 IRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGP 188
           IR L+ H    + +   P    ++ S   D  ++ WS++  R L +    +   E     
Sbjct: 139 IRVLRGHQLSITCLVVTPD-DSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPG 197

Query: 189 QSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVC 248
            S   L        ++++S G   + G     + I+      C+    F GH   VS + 
Sbjct: 198 HSSHVLC-------MAISSDGKYLASGDRSKLILIWEAQS--CQHLYTFTGHRDAVSGLA 248

Query: 249 FLPESYLLLTGGNDGKITLWDA--NSEVE 275
           F   ++ L +  +D  + +W+   NS VE
Sbjct: 249 FRRGTHQLYSTSHDRSVKVWNVAENSYVE 277


>gi|38327642 WD repeat domain 55 [Homo sapiens]
          Length = 383

 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 53/210 (25%), Positives = 87/210 (41%), Gaps = 22/210 (10%)

Query: 56  SVLFSPSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDS 115
           +V FS      +  S  + I VLDV   +        +   IN L L   EN+LA+ DD+
Sbjct: 89  AVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVD-ENVLATGDDT 147

Query: 116 GAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWIT 175
           G I++ D   +  +  +++H    + +A  P +   L + G               L I 
Sbjct: 148 GGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGC------------LGIF 195

Query: 176 NLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQEL 235
           N++    E +  PQS G L       S+++   G   +CG+ +G + +F   G     + 
Sbjct: 196 NIKRRRFELLSEPQS-GDLT------SVTLMKWGKKVACGSSEGTIYLFNWNGFGATSD- 247

Query: 236 GFKGHTSGVSQVCFLPESYLLLTGGNDGKI 265
            F      +  +  + ES LL TG  DG I
Sbjct: 248 RFALRAESIDCMVPVTES-LLCTGSTDGVI 276


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,171,013
Number of Sequences: 37866
Number of extensions: 707356
Number of successful extensions: 2905
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 176
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 1886
Number of HSP's gapped (non-prelim): 907
length of query: 358
length of database: 18,247,518
effective HSP length: 103
effective length of query: 255
effective length of database: 14,347,320
effective search space: 3658566600
effective search space used: 3658566600
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.