Guide to the Human Genome
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Search of human proteins with 32483361

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32483361 apoptotic peptidase activating factor 1 isoform d
[Homo sapiens]
         (1205 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...  2463   0.0  
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H...  2442   0.0  
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...  2434   0.0  
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho...  2413   0.0  
gi|32483363 apoptotic peptidase activating factor 1 isoform e [H...   634   0.0  
gi|32189425 WD repeat domain 69 [Homo sapiens]                        118   3e-26
gi|23199987 WD repeat domain 5B [Homo sapiens]                        117   9e-26
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]   115   2e-25
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]      115   2e-25
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   115   3e-25
gi|16554629 WD repeat domain 5 [Homo sapiens]                         115   3e-25
gi|16554627 WD repeat domain 5 [Homo sapiens]                         115   3e-25
gi|26665869 WD repeat domain 51B [Homo sapiens]                       105   3e-22
gi|21536371 telomerase-associated protein 1 [Homo sapiens]            105   3e-22
gi|113865883 WD repeat domain 38 [Homo sapiens]                       104   4e-22
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]    103   8e-22
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]           103   8e-22
gi|5174447 guanine nucleotide binding protein (G protein), beta ...   101   4e-21
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            100   6e-21
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            100   6e-21
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...   100   1e-20
gi|148727341 serine/threonine kinase receptor associated protein...    97   7e-20
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...    95   5e-19
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...    95   5e-19
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...    95   5e-19
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             90   1e-17
gi|189571685 WD repeat, sterile alpha motif and U-box domain con...    90   1e-17
gi|189571683 WD repeat, sterile alpha motif and U-box domain con...    90   1e-17
gi|189571681 WD repeat, sterile alpha motif and U-box domain con...    90   1e-17
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     90   1e-17

>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
            sapiens]
          Length = 1205

 Score = 2463 bits (6384), Expect = 0.0
 Identities = 1205/1205 (100%), Positives = 1205/1205 (100%)

Query: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
            MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60

Query: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120
            LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP
Sbjct: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120

Query: 121  QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180
            QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 121  QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180

Query: 181  GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240
            GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 181  GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240

Query: 241  ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300
            ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 241  ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300

Query: 301  MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360
            MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
Sbjct: 301  MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360

Query: 361  YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420
            YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
Sbjct: 361  YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420

Query: 421  KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480
            KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
Sbjct: 421  KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480

Query: 481  MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540
            MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
Sbjct: 481  MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540

Query: 541  SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600
            SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
Sbjct: 541  SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600

Query: 601  KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660
            KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
Sbjct: 601  KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660

Query: 661  LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720
            LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
Sbjct: 661  LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720

Query: 721  SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780
            SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
Sbjct: 721  SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780

Query: 781  INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLS 840
            INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLS
Sbjct: 781  INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLS 840

Query: 841  WVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHI 900
            WVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHI
Sbjct: 841  WVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHI 900

Query: 901  RRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 960
            RRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK
Sbjct: 901  RRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 960

Query: 961  KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSF 1020
            KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSF
Sbjct: 961  KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSF 1020

Query: 1021 DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL 1080
            DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL
Sbjct: 1021 DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL 1080

Query: 1081 RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDL 1140
            RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDL
Sbjct: 1081 RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDL 1140

Query: 1141 CFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1200
            CFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI
Sbjct: 1141 CFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1200

Query: 1201 LQTLE 1205
            LQTLE
Sbjct: 1201 LQTLE 1205


>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
            sapiens]
          Length = 1248

 Score = 2442 bits (6330), Expect = 0.0
 Identities = 1205/1248 (96%), Positives = 1205/1248 (96%), Gaps = 43/1248 (3%)

Query: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
            MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60

Query: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120
            LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP
Sbjct: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120

Query: 121  QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180
            QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 121  QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180

Query: 181  GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240
            GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 181  GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240

Query: 241  ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300
            ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 241  ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300

Query: 301  MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360
            MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
Sbjct: 301  MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360

Query: 361  YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420
            YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
Sbjct: 361  YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420

Query: 421  KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480
            KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
Sbjct: 421  KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480

Query: 481  MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540
            MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
Sbjct: 481  MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540

Query: 541  SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600
            SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
Sbjct: 541  SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600

Query: 601  KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660
            KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
Sbjct: 601  KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660

Query: 661  LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720
            LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
Sbjct: 661  LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720

Query: 721  SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780
            SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
Sbjct: 721  SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780

Query: 781  INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF------------------ 822
            INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF                  
Sbjct: 781  INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 840

Query: 823  -------------------------LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 857
                                     LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS
Sbjct: 841  STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 900

Query: 858  SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 917
            SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
Sbjct: 901  SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 960

Query: 918  EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 977
            EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
Sbjct: 961  EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1020

Query: 978  SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1037
            SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
Sbjct: 1021 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1080

Query: 1038 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1097
            FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
Sbjct: 1081 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1140

Query: 1098 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1157
            LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
Sbjct: 1141 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1200

Query: 1158 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1205
            WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Sbjct: 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1248


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
            sapiens]
          Length = 1194

 Score = 2434 bits (6307), Expect = 0.0
 Identities = 1194/1205 (99%), Positives = 1194/1205 (99%), Gaps = 11/1205 (0%)

Query: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
            MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60

Query: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120
            LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS           VRTVLCEGGVP
Sbjct: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS-----------VRTVLCEGGVP 109

Query: 121  QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180
            QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 110  QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 169

Query: 181  GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240
            GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 170  GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 229

Query: 241  ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300
            ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 230  ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 289

Query: 301  MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360
            MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
Sbjct: 290  MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 349

Query: 361  YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420
            YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
Sbjct: 350  YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 409

Query: 421  KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480
            KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
Sbjct: 410  KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 469

Query: 481  MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540
            MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
Sbjct: 470  MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 529

Query: 541  SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600
            SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
Sbjct: 530  SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 589

Query: 601  KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660
            KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
Sbjct: 590  KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 649

Query: 661  LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720
            LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
Sbjct: 650  LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709

Query: 721  SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780
            SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
Sbjct: 710  SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 769

Query: 781  INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLS 840
            INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLS
Sbjct: 770  INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLS 829

Query: 841  WVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHI 900
            WVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHI
Sbjct: 830  WVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHI 889

Query: 901  RRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 960
            RRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK
Sbjct: 890  RRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 949

Query: 961  KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSF 1020
            KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSF
Sbjct: 950  KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSF 1009

Query: 1021 DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL 1080
            DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL
Sbjct: 1010 DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL 1069

Query: 1081 RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDL 1140
            RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDL
Sbjct: 1070 RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDL 1129

Query: 1141 CFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1200
            CFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI
Sbjct: 1130 CFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1189

Query: 1201 LQTLE 1205
            LQTLE
Sbjct: 1190 LQTLE 1194


>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
            sapiens]
          Length = 1237

 Score = 2413 bits (6253), Expect = 0.0
 Identities = 1194/1248 (95%), Positives = 1194/1248 (95%), Gaps = 54/1248 (4%)

Query: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
            MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60

Query: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120
            LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS           VRTVLCEGGVP
Sbjct: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS-----------VRTVLCEGGVP 109

Query: 121  QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180
            QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 110  QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 169

Query: 181  GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240
            GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 170  GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 229

Query: 241  ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300
            ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 230  ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 289

Query: 301  MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360
            MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
Sbjct: 290  MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 349

Query: 361  YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420
            YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
Sbjct: 350  YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 409

Query: 421  KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480
            KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
Sbjct: 410  KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 469

Query: 481  MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540
            MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
Sbjct: 470  MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 529

Query: 541  SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600
            SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
Sbjct: 530  SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 589

Query: 601  KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660
            KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
Sbjct: 590  KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 649

Query: 661  LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720
            LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
Sbjct: 650  LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709

Query: 721  SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780
            SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
Sbjct: 710  SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 769

Query: 781  INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF------------------ 822
            INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF                  
Sbjct: 770  INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 829

Query: 823  -------------------------LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 857
                                     LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS
Sbjct: 830  STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 889

Query: 858  SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 917
            SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
Sbjct: 890  SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 949

Query: 918  EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 977
            EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
Sbjct: 950  EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1009

Query: 978  SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1037
            SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
Sbjct: 1010 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1069

Query: 1038 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1097
            FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
Sbjct: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1129

Query: 1098 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1157
            LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
Sbjct: 1130 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1189

Query: 1158 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1205
            WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Sbjct: 1190 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237


>gi|32483363 apoptotic peptidase activating factor 1 isoform e [Homo
           sapiens]
          Length = 338

 Score =  634 bits (1636), Expect = 0.0
 Identities = 322/338 (95%), Positives = 326/338 (96%), Gaps = 3/338 (0%)

Query: 1   MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
           MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1   MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60

Query: 61  LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120
           LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP
Sbjct: 61  LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120

Query: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180
           QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180

Query: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240
           GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240

Query: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300
           ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300

Query: 301 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRW 338
           MKKADLPEQAHSIIKECK   +V      +L D  ++W
Sbjct: 301 MKKADLPEQAHSIIKECK---VVERCHWGILTDLLHKW 335


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  118 bits (296), Expect = 3e-26
 Identities = 78/266 (29%), Positives = 125/266 (46%), Gaps = 33/266 (12%)

Query: 614 HTDAVYHACFSED-GQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI 672
           H + VY   F+   G +IA+   DKT +++  ETG+     + H  E++C +F+     +
Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLV 192

Query: 673 ATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 732
           AT S+D   K+W+   GE V+T   HS ++    F  S   ++  TGS D  + +WD + 
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII--TGSFDHTVVVWDADT 250

Query: 733 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792
               N + GH   ++   F+ D  L+ + S D T KLWDAT+     ++           
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT---------- 300

Query: 793 PQEDMEVIVKCCSW--------SADG-ARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVH 843
              D E++  C  +        SADG ARI  AA          +R  +A   GH   + 
Sbjct: 301 -GHDDEILDSCFDYTGKLIATASADGTARIFSAA----------TRKCIAKLEGHEGEIS 349

Query: 844 GVMFSPDGSSFLTSSDDQTIRLWETK 869
            + F+P G+  LT S D+T R+W+ +
Sbjct: 350 KISFNPQGNHLLTGSSDKTARIWDAQ 375



 Score =  105 bits (261), Expect = 3e-22
 Identities = 89/378 (23%), Positives = 155/378 (41%), Gaps = 54/378 (14%)

Query: 653  IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 712
            +KAH   +   A +       T S D+  K+W++ +GE ++T + H   V    F N+ +
Sbjct: 88   LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAF-NNPY 146

Query: 713  HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 772
               +ATGS D   KLW +   +C +T  GHT  +    F+P   L+A+ S D T KLWD 
Sbjct: 147  GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206

Query: 773  TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSK 831
             +  E  ++                E+I    S++  G RI+  +  + + +W+ D+  K
Sbjct: 207  QNGEEVYTLR-----------GHSAEII--SLSFNTSGDRIITGSFDHTVVVWDADTGRK 253

Query: 832  VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENE 891
            V    GH + +    F+ D S  LT S D+T +LW+        A   K    +   ++E
Sbjct: 254  VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD--------ATNGKCVATLTGHDDE 305

Query: 892  VMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR 951
            ++    D+  +L                             IA    +G   I      +
Sbjct: 306  ILDSCFDYTGKL-----------------------------IATASADGTARIFSAATRK 336

Query: 952  IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRL- 1009
                   H+  +  I F      L++ S D   ++W+ Q  +C+  L GH + +      
Sbjct: 337  CIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN 396

Query: 1010 LKNSRLLSWSFDGTVKVW 1027
             K + +++ S D T ++W
Sbjct: 397  YKGNIVITGSKDNTCRIW 414



 Score =  101 bits (251), Expect = 5e-21
 Identities = 68/256 (26%), Positives = 119/256 (46%), Gaps = 16/256 (6%)

Query: 612 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 671
           R HT  +    F+     +A+   D T +++  + GE++  ++ H  E++  +F+T    
Sbjct: 174 RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDR 233

Query: 672 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731
           I T S D  V +W++ TG  V+    H  +++   F       L+ TGS D   KLWD  
Sbjct: 234 IITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS--LILTGSMDKTCKLWDAT 291

Query: 732 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 791
             +C  T+ GH + +    F    KL+A+ SADGT +++   SA  RK I        LE
Sbjct: 292 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF---SAATRKCI------AKLE 342

Query: 792 DPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPD 850
             + ++  I    S++  G  ++  + +K   +W+  +   +    GH   +    F+  
Sbjct: 343 GHEGEISKI----SFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYK 398

Query: 851 GSSFLTSSDDQTIRLW 866
           G+  +T S D T R+W
Sbjct: 399 GNIVITGSKDNTCRIW 414



 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 47/164 (28%), Positives = 85/164 (51%), Gaps = 6/164 (3%)

Query: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
           +R H+  +    F+  G RI +   D T+ V+ A+TG K+  +  H  E+   +F+ D  
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274

Query: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQV--NCCHFTNSSHHLLLATGSSDCFLKLW 728
            I T S+DK  K+W++  G+ V T   H +++  +C  +T      L+AT S+D   +++
Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK----LIATASADGTARIF 330

Query: 729 DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 772
               ++C   + GH   ++   F+P    L + S+D T ++WDA
Sbjct: 331 SAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDA 374



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 64/301 (21%), Positives = 123/301 (40%), Gaps = 8/301 (2%)

Query: 836  RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVM-- 893
            + H+  +  V  +  GS F+T S D+T +LW+T    + + +   + V      N     
Sbjct: 89   KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGD 148

Query: 894  -VLAVDHIRRLQLINGRTGQIDYLTE---AQVSCCCLSPHLQYIAFGDENGAIEILELVN 949
             +      +  +L +  TG+  +      A++ C   +P    +A G  +   ++ ++ N
Sbjct: 149  KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN 208

Query: 950  NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFR 1008
                 +   H   +  + F      +I+ S D  + VW+    + +  L GH   +    
Sbjct: 209  GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSAS 268

Query: 1009 LLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAK 1067
               + S +L+ S D T K+W+   G        H   +L     +     ++ SAD TA+
Sbjct: 269  FNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTAR 328

Query: 1068 IWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSE 1127
            I+S      + +L GH G +   +F+     L TG  +   RIW+   G+ L +    ++
Sbjct: 329  IFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTD 388

Query: 1128 E 1128
            E
Sbjct: 389  E 389



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 67/297 (22%), Positives = 118/297 (39%), Gaps = 8/297 (2%)

Query: 823  LWNTDSRSKVADCRGHLSWVHGVMFS-PDGSSFLTSSDDQTIRLW--ETKKVCKNSAVML 879
            LW+T S  ++    GH + V+ + F+ P G    T S D+T +LW  ET K         
Sbjct: 118  LWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHT 177

Query: 880  KQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE---AQVSCCCLSPHLQYIAFG 936
             + V + F     +V         +L + + G+  Y      A++     +     I  G
Sbjct: 178  AEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITG 237

Query: 937  DENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF 996
              +  + + +    R       H   +    F  D   +++ S D   ++W+    KC+ 
Sbjct: 238  SFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVA 297

Query: 997  -LRGHQETVKDFRLLKNSRLLSW-SFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDA 1054
             L GH + + D       +L++  S DGT ++++  T         H+G +     +   
Sbjct: 298  TLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG 357

Query: 1055 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1111
                + S+DKTA+IW       L  L GH   +   AF+    ++ TG  +   RIW
Sbjct: 358  NHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 40/182 (21%), Positives = 80/182 (43%), Gaps = 7/182 (3%)

Query: 952  IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKD--FR 1008
            +F+    H   + ++         I+ S D   ++W+    ++   L GH+  V    F 
Sbjct: 84   LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143

Query: 1009 LLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKI 1068
                 ++ + SFD T K+W++ TG     F  H   ++    +  +T  ++ S D TAK+
Sbjct: 144  NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203

Query: 1069 WSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL----CAP 1124
            W       ++ LRGH+  +   +F+     + TG  +  + +W+   G  +++    CA 
Sbjct: 204  WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263

Query: 1125 LS 1126
            +S
Sbjct: 264  IS 265


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  117 bits (292), Expect = 9e-26
 Identities = 72/258 (27%), Positives = 121/258 (46%), Gaps = 18/258 (6%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H   +    +S D  R+ S   DKTL+++   +G+ L  +K H + V CC F+     I 
Sbjct: 82  HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLII 141

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           + S D+ VKIW   TG+ + T   HS+ V+  HF  S    L+ +GS D   ++WD    
Sbjct: 142 SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS--LIVSGSYDGLCRIWDAASG 199

Query: 734 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792
           +C  T+    N  V+  +FSP+ K + + + D TLKLWD +     K+            
Sbjct: 200 QCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT---------- 249

Query: 793 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLWNTDSRSKVADCRGHLSWVHGVMFSPD 850
                E      ++S  G + +V+    N +++WN  ++  V   +GH   V      P 
Sbjct: 250 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPT 308

Query: 851 GSSFLTSS--DDQTIRLW 866
            +   +++  +D+TI+LW
Sbjct: 309 ENLIASAALENDKTIKLW 326



 Score =  109 bits (272), Expect = 2e-23
 Identities = 81/304 (26%), Positives = 148/304 (48%), Gaps = 30/304 (9%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           HT+AV    FS +G+ +AS  AD+ + ++ A  G+    +  H  E+   A+S+D   + 
Sbjct: 40  HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           + S DK +K+W+  +G+ + T   HS  V CC+F   S+  L+ +GS D  +K+W++   
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSN--LIISGSFDETVKIWEVKTG 157

Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793
           +C  T+  H++ V+   F+    L+ S S DG  ++WDA S    K++            
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL------------ 205

Query: 794 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVM--FSPD 850
            +D    V    +S +G  I+ A   N + LW+      +    GH +  + +   FS  
Sbjct: 206 VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVT 265

Query: 851 GSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAVDHIR 901
           G  ++ S S+D  + +W  +TK++ +     L+   DVV        EN +   A+++ +
Sbjct: 266 GGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISAACHPTENLIASAALENDK 321

Query: 902 RLQL 905
            ++L
Sbjct: 322 TIKL 325



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 74/304 (24%), Positives = 145/304 (47%), Gaps = 27/304 (8%)

Query: 738  TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797
            T+ GHT +V+  +FSP+ + LAS SAD  + +W A      K++    +  NLE      
Sbjct: 36   TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL----YGHNLE------ 85

Query: 798  EVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLT 856
               +   +WS+D +R++ A+ +K + LW+  S   +   +GH ++V    F+P  +  ++
Sbjct: 86   ---ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIIS 142

Query: 857  SSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ-I 913
             S D+T+++WE K  K  K  +        V F  +  ++++  +    ++ +  +GQ +
Sbjct: 143  GSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCL 202

Query: 914  DYLTE---AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI--QF 968
              L +     VS    SP+ +YI     +  +++ +    R  ++   HK   + I   F
Sbjct: 203  KTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANF 262

Query: 969  T-ADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRLLSWSF---DGT 1023
            +    K ++S S+D  + +WN Q  + +  L+GH + V          L++ +    D T
Sbjct: 263  SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKT 322

Query: 1024 VKVW 1027
            +K+W
Sbjct: 323  IKLW 326



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 73/280 (26%), Positives = 127/280 (45%), Gaps = 24/280 (8%)

Query: 939  NGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW---NWQLDKCI 995
            N + E+ E  N  +  +   H + V  ++F+ + + L SSS D  I +W   + + +K +
Sbjct: 20   NQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL 79

Query: 996  FLRGHQETVKDFRLLK-NSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDA 1054
            +  GH   + D      +SRL+S S D T+K+W++ +G   K    H   V  C+ +  +
Sbjct: 80   Y--GHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS 137

Query: 1055 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVS 1114
                S S D+T KIW       L  L  H+  V    F+   +L+ +G  +G  RIW+ +
Sbjct: 138  NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197

Query: 1115 NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYT 1172
            +G+ L                 V+ + FSP+GK +++A     +K W+   G   +T+  
Sbjct: 198  SGQCLKTLVDDDNPP-------VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY-- 248

Query: 1173 NGTNLKKIHVSPDFK-------TYVTVDNLGILYILQTLE 1205
             G   +K  +  +F           + DNL  ++ LQT E
Sbjct: 249  TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 288



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 46/166 (27%), Positives = 84/166 (50%), Gaps = 8/166 (4%)

Query: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
           ++ H++ V+   F+     I S   D+T+++++ +TG+ L  + AH D V    F+    
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS 180

Query: 671 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
            I + S D   +IW++ +G+ + T  D+ +  V+   F+ +  ++L AT   D  LKLWD
Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTAT--LDNTLKLWD 238

Query: 730 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 771
            ++  C  T  GH N   +C F+       K + S S D  + +W+
Sbjct: 239 YSRGRCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 283



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 62/288 (21%), Positives = 118/288 (40%), Gaps = 13/288 (4%)

Query: 837  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMV 894
            GH   V  V FSP+G    +SS D+ I +W     K  K       +  DV +  +   +
Sbjct: 39   GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98

Query: 895  LAVDHIRRLQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNR 951
            ++    + L+L + R+G+     +     V CC  +P    I  G  +  ++I E+   +
Sbjct: 99   VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158

Query: 952  IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRL 1009
              ++   H   V  + F      ++S S D   ++W+    +C+   +      V   + 
Sbjct: 159  CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218

Query: 1010 LKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATK---FSSTSADKT 1065
              N + +L+ + D T+K+W+   G   K +  H+        +   T      S S D  
Sbjct: 219  SPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 278

Query: 1066 AKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG--DDNGEIRIW 1111
              IW+      + +L+GH   V  +A      L+A+   +++  I++W
Sbjct: 279  VYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 36/114 (31%), Positives = 54/114 (47%), Gaps = 7/114 (6%)

Query: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLC--CAFS-TDDRFIATCSVDK 679
           FS +G+ I +   D TL+++    G  L     H++E  C    FS T  ++I + S D 
Sbjct: 218 FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 277

Query: 680 KVKIWNSMTGELVHTYDEHSEQV--NCCHFTNSSHHLLLATGSSDCFLKLWDLN 731
            V IWN  T E+V     H++ V    CH T +   +  A   +D  +KLW  N
Sbjct: 278 LVYIWNLQTKEIVQKLQGHTDVVISAACHPTENL--IASAALENDKTIKLWMSN 329


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score =  115 bits (289), Expect = 2e-25
 Identities = 73/259 (28%), Positives = 134/259 (51%), Gaps = 10/259 (3%)

Query: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC-AFSTDD 669
           ++ H+ AV    ++ DG  + S   DKT+ V+ +ETGE++  +K H   V  C       
Sbjct: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP 164

Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
           + + T S D  VK+W+      + T+ +++ QV    F ++S  ++  +G  D  +K+WD
Sbjct: 165 QLVCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQII--SGGIDNDIKVWD 221

Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789
           L Q +   TM GH +SV     S +   L S + D T+++WD      ++   VK F  N
Sbjct: 222 LRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC-VKIFQGN 280

Query: 790 LEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFS 848
           + + ++++      CSWS DG++I   + ++ +++W+T SR  +    GH   ++ V F 
Sbjct: 281 VHNFEKNL----LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336

Query: 849 PDGSSFLTSSDDQTIRLWE 867
           PD    +++S D+ + + E
Sbjct: 337 PDEPIIISASSDKRLYMGE 355



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 84/340 (24%), Positives = 141/340 (41%), Gaps = 52/340 (15%)

Query: 650 LLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVH--TYDEHSEQVNCCHF 707
           ++ +  HE EV CC F  +   +A+   D+ + +WN + G+  +  T   HS  V   H+
Sbjct: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHSGAVMELHY 117

Query: 708 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHC---RFSPDDKLLASCSAD 764
                  +L + S+D  + +WD    E    + GHT+ VN C   R  P  +L+ + S D
Sbjct: 118 NTDGS--MLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP--QLVCTGSDD 173

Query: 765 GTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLW 824
           GT+KLWD      RK   ++ F       Q   +V+    + ++D   I     N I +W
Sbjct: 174 GTVKLWDI-----RKKAAIQTF-------QNTYQVLAVTFNDTSDQI-ISGGIDNDIKVW 220

Query: 825 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVD 884
           +          RGH   V G+  S +GS  L+++ D T+R+W+ +          K+   
Sbjct: 221 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAP------KERCV 274

Query: 885 VVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEI 944
            +FQ N                        +  E  +  C  SP    IA G  +  + +
Sbjct: 275 KIFQGNV-----------------------HNFEKNLLRCSWSPDGSKIAAGSADRFVYV 311

Query: 945 LELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEI 984
            +  + RI      H  ++  + F  DE  +IS+S D  +
Sbjct: 312 WDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 76/317 (23%), Positives = 138/317 (43%), Gaps = 49/317 (15%)

Query: 801  VKCCSWSADGARIMVAAKNK-IFLWNT-DSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS 858
            V CC +  +G+ +  A  ++ I LWN        A  +GH   V  + ++ DGS   ++S
Sbjct: 69   VYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSAS 128

Query: 859  DDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE 918
             D+T+ +W+++                                R++ + G T  ++    
Sbjct: 129  TDKTVAVWDSETG-----------------------------ERVKRLKGHTSFVN---- 155

Query: 919  AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISS 978
               SC       Q +  G ++G +++ ++      Q+ FQ+   V  + F      +IS 
Sbjct: 156  ---SCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISG 211

Query: 979  SDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL-KNSRLLSWSFDGTVKVWNIIT-GNKE 1035
              D +I+VW+ + +K  + +RGH ++V    L  + S LLS + D TV+VW++     KE
Sbjct: 212  GIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKE 271

Query: 1036 KDFVCHQGTV-------LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1088
            +     QG V       L C  S D +K ++ SAD+   +W       L++L GH G + 
Sbjct: 272  RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331

Query: 1089 CSAFSVDSTLLATGDDN 1105
              AF  D  ++ +   +
Sbjct: 332  EVAFHPDEPIIISASSD 348



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 59/291 (20%), Positives = 115/291 (39%), Gaps = 11/291 (3%)

Query: 918  EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLI 976
            E +V CC   P+   +A    +  I +  +  +    +  + H   V  + +  D   L 
Sbjct: 66   EGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLF 125

Query: 977  SSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL--SWSFDGTVKVWNIITGN 1033
            S+S D  + VW+ +  + +  L+GH   V      +    L  + S DGTVK+W+I    
Sbjct: 126  SASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI---R 182

Query: 1034 KEKDFVCHQGT--VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1091
            K+      Q T  VL+   +  + +  S   D   K+W        + +RGH   V   +
Sbjct: 183  KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242

Query: 1092 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI- 1150
             S + + L +   +  +R+W+V        C  + +         +    +SPDG  +  
Sbjct: 243  LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302

Query: 1151 -SAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1200
             SA  ++  W+  +         +  ++ ++   PD    ++  +   LY+
Sbjct: 303  GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353



 Score = 38.1 bits (87), Expect = 0.051
 Identities = 32/98 (32%), Positives = 44/98 (44%), Gaps = 15/98 (15%)

Query: 1073 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1132
            L  P+  L GH G V C  F  + + LA+   +  I +WNV        C     +  AT
Sbjct: 55   LQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD-----C-----DNYAT 104

Query: 1133 ---HGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGE 1165
               H G V +L ++ DG ML SA     +  W+  TGE
Sbjct: 105  LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGE 142


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score =  115 bits (289), Expect = 2e-25
 Identities = 72/253 (28%), Positives = 116/253 (45%), Gaps = 15/253 (5%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           HTD +   CF   G ++A+   D T++++    G+ +L  + H   V  C + +   F+A
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVA 452

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           + S+DK  KIW+  +     T   H++ VN   F   S+ LL  T S+D  L +WD    
Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLL--TSSADKTLSIWDARTG 510

Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793
            C  +++GH +S+N   F P   ++ASC A G  KLWD        SI++         P
Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDI--------GP 562

Query: 794 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 853
               EV     ++ + G  +  A+ N +         ++    GH +  H V+FS DG  
Sbjct: 563 SPGNEV-----NFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEI 617

Query: 854 FLTSSDDQTIRLW 866
             +   D T+R W
Sbjct: 618 LFSGGSDGTVRTW 630



 Score = 73.9 bits (180), Expect = 8e-13
 Identities = 71/312 (22%), Positives = 124/312 (39%), Gaps = 36/312 (11%)

Query: 690 ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHC 749
           +L + +  H   V+C       H  +L +   D   K+  L +     T FGHT+ ++ C
Sbjct: 343 KLKNIFRLHELPVSCVSM--QPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDC 400

Query: 750 RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 809
            F P    LA+ S D T+KLWD    +           L  E         V  C+W + 
Sbjct: 401 CFHPSGDKLATSSGDTTVKLWDLCKGD---------CILTFEGHSR----AVWSCTWHSC 447

Query: 810 GARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 868
           G  +  ++ +K   +W+ +S        GH   V+ + F P  ++ LTSS D+T+ +W+ 
Sbjct: 448 GNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDA 507

Query: 869 KK-VCKNSAVMLKQEV-DVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCL 926
           +  +C+ S       + D +F     M+ + D         G T   D+     +    +
Sbjct: 508 RTGICEQSLYGHMHSINDAIFDPRGHMIASCDAC-------GVTKLWDFRKLLPIVSIDI 560

Query: 927 SPHL----------QYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLI 976
            P            + +A    NG I +L+L +  I      H+     + F+ D + L 
Sbjct: 561 GPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEILF 619

Query: 977 SSSDDAEIQVWN 988
           S   D  ++ W+
Sbjct: 620 SGGSDGTVRTWS 631



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 64/290 (22%), Positives = 117/290 (40%), Gaps = 18/290 (6%)

Query: 875  SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 934
            S V ++   D++    E  +  V  + +  ++    G  D+L++     CC  P    +A
Sbjct: 356  SCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSD-----CCFHPSGDKLA 410

Query: 935  FGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC 994
                +  +++ +L       +   H + VW   + +    + SSS D   ++W+   ++C
Sbjct: 411  TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470

Query: 995  -IFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISH 1052
               L GH ++V        S  LL+ S D T+ +W+  TG  E+    H  ++       
Sbjct: 471  RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530

Query: 1053 DATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1112
                 +S  A    K+W F  LLP+  +           F     +LA    NG I + +
Sbjct: 531  RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLD 590

Query: 1113 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWN 1160
            + +GE+  L           H      + FS DG++L S G  G ++ W+
Sbjct: 591  LKSGEIHKLMG---------HENEAHTVVFSHDGEILFSGGSDGTVRTWS 631



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 57/208 (27%), Positives = 84/208 (40%), Gaps = 16/208 (7%)

Query: 959  HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNS-R 1014
            H+  V  +     +  L+S  +D   +V    L KC  L    GH + + D     +  +
Sbjct: 351  HELPVSCVSMQPHKDILVSCGEDRLWKVLG--LPKCNVLLTGFGHTDWLSDCCFHPSGDK 408

Query: 1015 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1074
            L + S D TVK+W++  G+    F  H   V SC         +S+S DKT+KIW  +  
Sbjct: 409  LATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSE 468

Query: 1075 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1134
                 L GH   V    F   S  L T   +  + IW+   G        + E+    H 
Sbjct: 469  RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG--------ICEQSLYGHM 520

Query: 1135 GWVTDLCFSPDGKMLIS--AGGYIKWWN 1160
              + D  F P G M+ S  A G  K W+
Sbjct: 521  HSINDAIFDPRGHMIASCDACGVTKLWD 548



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 45/163 (27%), Positives = 69/163 (42%), Gaps = 3/163 (1%)

Query: 608 RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFST 667
           R  +  HTD+V    F      + +  ADKTL ++ A TG     +  H   +    F  
Sbjct: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530

Query: 668 DDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 727
               IA+C      K+W+      + + D      N  +F +S    +LA  S +  + L
Sbjct: 531 RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGR--VLAQASGNGVIHL 588

Query: 728 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770
            DL   E    M GH N  +   FS D ++L S  +DGT++ W
Sbjct: 589 LDLKSGEIHKLM-GHENEAHTVVFSHDGEILFSGGSDGTVRTW 630



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 47/199 (23%), Positives = 80/199 (40%), Gaps = 2/199 (1%)

Query: 916  LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 975
            L E  VSC  + PH   +    E+   ++L L    +  + F H   +    F      L
Sbjct: 350  LHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKL 409

Query: 976  ISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLK-NSRLLSWSFDGTVKVWNIITGN 1033
             +SS D  +++W+     CI    GH   V         + + S S D T K+W++ +  
Sbjct: 410  ATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSER 469

Query: 1034 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1093
                   H  +V S +    +    ++SADKT  IW     +    L GH   +  + F 
Sbjct: 470  CRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFD 529

Query: 1094 VDSTLLATGDDNGEIRIWN 1112
                ++A+ D  G  ++W+
Sbjct: 530  PRGHMIASCDACGVTKLWD 548


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  115 bits (287), Expect = 3e-25
 Identities = 72/278 (25%), Positives = 126/278 (45%), Gaps = 40/278 (14%)

Query: 613 PHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI 672
           P T  ++H  FS     + S   D T++V+  ETG+    +K H D V   +F    + +
Sbjct: 110 PVTRVIFHPVFSV----MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165

Query: 673 ATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 732
           A+CS D  +K+W+    E + T   H   V+      +  H++ A  S D  +K+W++  
Sbjct: 166 ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSA--SRDKTIKMWEVQT 223

Query: 733 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792
             C  T  GH   V   R + D  L+ASCS D T+++W   +   +  +           
Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL----------- 272

Query: 793 PQEDMEVIVKCCSWSAD--------------------GARIMVAAKNK-IFLWNTDSRSK 831
              + E +V+C SW+ +                    G  ++  +++K I +W+  +   
Sbjct: 273 --REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMC 330

Query: 832 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 869
           +    GH +WV GV+F   G   L+ +DD+T+R+W+ K
Sbjct: 331 LMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK 368



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 62/246 (25%), Positives = 102/246 (41%), Gaps = 30/246 (12%)

Query: 928  PHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 987
            P    +    E+  I++ +       ++   H  +V  I F    K L S S D  I++W
Sbjct: 118  PVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW 177

Query: 988  NWQLDKCI-FLRGHQETVKDFRLLKNS-RLLSWSFDGTVKVWNIITGNKEKDFVCHQGTV 1045
            ++Q  +CI  + GH   V    ++ N   ++S S D T+K+W + TG   K F  H+  V
Sbjct: 178  DFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWV 237

Query: 1046 LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-------- 1097
                 + D T  +S S D+T ++W         ELR H   V C +++ +S+        
Sbjct: 238  RMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEAT 297

Query: 1098 ------------LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPD 1145
                         L +G  +  I++W+VS G  L             H  WV  + F   
Sbjct: 298  GSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG--------HDNWVRGVLFHSG 349

Query: 1146 GKMLIS 1151
            GK ++S
Sbjct: 350  GKFILS 355



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 75/338 (22%), Positives = 137/338 (40%), Gaps = 45/338 (13%)

Query: 741  GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM--E 798
            GH + V    F P   ++ S S D T+K+WD  + +  +++  K    +++D   D   +
Sbjct: 106  GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTL--KGHTDSVQDISFDHSGK 163

Query: 799  VIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS 858
            ++  C            +A   I LW+      +    GH   V  V   P+G   +++S
Sbjct: 164  LLASC------------SADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSAS 211

Query: 859  DDQTIRLWETKK-VCKNSAVMLKQEVDVVFQENEVMVLAV---DHIRRLQLINGRTGQID 914
             D+TI++WE +   C  +    ++ V +V    +  ++A    D   R+ ++  +  + +
Sbjct: 212  RDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAE 271

Query: 915  YLT-EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 973
                E  V C   +P   Y +  +  G+                + KK+     F     
Sbjct: 272  LREHEHVVECISWAPESSYSSISEATGS----------------ETKKSGKPGPF----- 310

Query: 974  TLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1031
             L+S S D  I++W+     C+  L GH   V+        + +LS + D T++VW+   
Sbjct: 311  -LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369

Query: 1032 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1069
                K    H+  V S D    A    + S D+T K+W
Sbjct: 370  KRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407



 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 66/303 (21%), Positives = 120/303 (39%), Gaps = 29/303 (9%)

Query: 837  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMV 894
            GH S V  V+F P  S  +++S+D TI++W  ET    +          D+ F  +  ++
Sbjct: 106  GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165

Query: 895  LAVDHIRRLQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNR 951
             +      ++L + +  +           VS   + P+  +I     +  I++ E+    
Sbjct: 166  ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGY 225

Query: 952  IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC-IFLRGHQETVKDFRLL 1010
              ++   H++ V  ++   D   + S S+D  ++VW     +C   LR H+  V+     
Sbjct: 226  CVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWA 285

Query: 1011 KNSR---------------------LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCD 1049
              S                      LLS S D T+K+W++ TG      V H   V    
Sbjct: 286  PESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGV- 344

Query: 1050 ISHDATKFSSTSAD-KTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI 1108
            + H   KF  + AD KT ++W +     +  L  H   V    F   +  + TG  +  +
Sbjct: 345  LFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTV 404

Query: 1109 RIW 1111
            ++W
Sbjct: 405  KVW 407



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 40/155 (25%), Positives = 66/155 (42%), Gaps = 10/155 (6%)

Query: 1013 SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1072
            S ++S S D T+KVW+  TG+ E+    H  +V      H     +S SAD T K+W F 
Sbjct: 121  SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180

Query: 1073 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1132
                +  + GH+  V   A   +   + +   +  I++W V  G  +        +    
Sbjct: 181  GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV--------KTFTG 232

Query: 1133 HGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGE 1165
            H  WV  +  + DG ++ S      ++ W V T E
Sbjct: 233  HREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE 267



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 25/81 (30%), Positives = 39/81 (48%)

Query: 604 TNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC 663
           T +  + +  H + V    F   G+ I SC  DKTL+V+  +    +  + AHE  V   
Sbjct: 327 TGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSL 386

Query: 664 AFSTDDRFIATCSVDKKVKIW 684
            F     ++ T SVD+ VK+W
Sbjct: 387 DFHKTAPYVVTGSVDQTVKVW 407



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 25/110 (22%), Positives = 46/110 (41%), Gaps = 10/110 (9%)

Query: 1078 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1137
            + L GH   V    F    +++ +  ++  I++W+   G+         E     H   V
Sbjct: 102  YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDF--------ERTLKGHTDSV 153

Query: 1138 TDLCFSPDGKML--ISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1185
             D+ F   GK+L   SA   IK W+    E  +T + +  N+  + + P+
Sbjct: 154  QDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  115 bits (287), Expect = 3e-25
 Identities = 82/304 (26%), Positives = 150/304 (49%), Gaps = 30/304 (9%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           HT AV    FS +G+ +AS  ADK ++++ A  G+    I  H+  +   A+S+D   + 
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           + S DK +KIW+  +G+ + T   HS  V CC+F   S+  L+ +GS D  +++WD+   
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTG 161

Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793
           +C  T+  H++ V+   F+ D  L+ S S DG  ++WD  S    K++        ++D 
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDD 213

Query: 794 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVM--FSPD 850
              +  +     +S +G  I+ A   N + LW+      +    GH +  + +   FS  
Sbjct: 214 NPPVSFV----KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269

Query: 851 GSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAVDHIR 901
           G  ++ S S+D  + +W  +TK++ +     L+   DVV        EN +   A+++ +
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISTACHPTENIIASAALENDK 325

Query: 902 RLQL 905
            ++L
Sbjct: 326 TIKL 329



 Score =  114 bits (284), Expect = 7e-25
 Identities = 68/260 (26%), Positives = 121/260 (46%), Gaps = 18/260 (6%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H   +    +S D   + S   DKTL+++   +G+ L  +K H + V CC F+     I 
Sbjct: 86  HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           + S D+ V+IW+  TG+ + T   HS+ V+  HF       L+ + S D   ++WD    
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS--LIVSSSYDGLCRIWDTASG 203

Query: 734 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792
           +C  T+    N  V+  +FSP+ K + + + D TLKLWD +     K+            
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---------- 253

Query: 793 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLWNTDSRSKVADCRGHLSWVHGVMFSPD 850
                E      ++S  G + +V+    N +++WN  ++  V   +GH   V      P 
Sbjct: 254 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312

Query: 851 GSSFLTSS--DDQTIRLWET 868
            +   +++  +D+TI+LW++
Sbjct: 313 ENIIASAALENDKTIKLWKS 332



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 61/223 (27%), Positives = 112/223 (50%), Gaps = 23/223 (10%)

Query: 653 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 712
           +  H   V    FS +  ++A+ S DK +KIW +  G+   T   H   ++   +++ S+
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 713 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 772
             LL + S D  LK+WD++  +C  T+ GH+N V  C F+P   L+ S S D ++++WD 
Sbjct: 101 --LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158

Query: 773 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDS--- 828
            +    K++          DP       V    ++ DG+ I+ ++ + +  +W+T S   
Sbjct: 159 KTGKCLKTLPAH------SDP-------VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205

Query: 829 -RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 870
            ++ + D    +S+   V FSP+G   L ++ D T++LW+  K
Sbjct: 206 LKTLIDDDNPPVSF---VKFSPNGKYILAATLDNTLKLWDYSK 245



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 74/345 (21%), Positives = 150/345 (43%), Gaps = 61/345 (17%)

Query: 738  TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797
            T+ GHT +V+  +FSP+ + LAS SAD  +K+W A      K+I+  +  L + D     
Sbjct: 40   TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK--LGISD----- 92

Query: 798  EVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLT 856
                   +WS+D   ++ A+ +K + +W+  S   +   +GH ++V    F+P  +  ++
Sbjct: 93   ------VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146

Query: 857  SSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 914
             S D+++R+W+ K  K  K           V F  +  ++++  +    ++ +  +GQ  
Sbjct: 147  GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ-- 204

Query: 915  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 974
                      CL   +      D+N  +                       ++F+ + K 
Sbjct: 205  ----------CLKTLID-----DDNPPVSF---------------------VKFSPNGKY 228

Query: 975  LISSSDDAEIQVWNWQLDKCI-FLRGHQE----TVKDFRLLKNSRLLSWSFDGTVKVWNI 1029
            +++++ D  +++W++   KC+    GH+        +F +     ++S S D  V +WN+
Sbjct: 229  ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288

Query: 1030 ITGNKEKDFVCHQGTVLS--CDISHDATKFSSTSADKTAKIWSFD 1072
             T    +    H   V+S  C  + +    ++   DKT K+W  D
Sbjct: 289  QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 11/176 (6%)

Query: 997  LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDAT 1055
            L GH + V   +   N   L S S D  +K+W    G  EK    H+  +     S D+ 
Sbjct: 41   LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 1056 KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1115
               S S DKT KIW       L  L+GH+  V C  F+  S L+ +G  +  +RIW+V  
Sbjct: 101  LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160

Query: 1116 GELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQT 1169
            G+ L      S+  +A H        F+ DG +++S+   G  + W+  +G+  +T
Sbjct: 161  GKCLKTLPAHSDPVSAVH--------FNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 46/166 (27%), Positives = 85/166 (51%), Gaps = 8/166 (4%)

Query: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
           ++ H++ V+   F+     I S   D++++++  +TG+ L  + AH D V    F+ D  
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184

Query: 671 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
            I + S D   +IW++ +G+ + T  D+ +  V+   F+ +  ++L AT   D  LKLWD
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWD 242

Query: 730 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 771
            ++ +C  T  GH N   +C F+       K + S S D  + +W+
Sbjct: 243 YSKGKCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 287



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 59/291 (20%), Positives = 123/291 (42%), Gaps = 19/291 (6%)

Query: 837  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLW-----ETKKVCKNSAVMLKQEVDVVFQENE 891
            GH   V  V FSP+G    +SS D+ I++W     + +K      + +    DV +  + 
Sbjct: 43   GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS---DVAWSSDS 99

Query: 892  VMVLAVDHIRRLQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELV 948
             ++++    + L++ +  +G+     +     V CC  +P    I  G  + ++ I ++ 
Sbjct: 100  NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159

Query: 949  NNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI--FLRGHQETVKD 1006
              +  ++   H   V  + F  D   ++SSS D   ++W+    +C+   +      V  
Sbjct: 160  TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219

Query: 1007 FRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATK---FSSTSA 1062
             +   N + +L+ + D T+K+W+   G   K +  H+        +   T      S S 
Sbjct: 220  VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279

Query: 1063 DKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG--DDNGEIRIW 1111
            D    IW+      + +L+GH   V  +A      ++A+   +++  I++W
Sbjct: 280  DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 12/166 (7%)

Query: 1041 HQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGCVRCSAFSVDSTLL 1099
            H   V S   S +    +S+SADK  KIW ++D       + GH   +   A+S DS LL
Sbjct: 44   HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNLL 102

Query: 1100 ATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1157
             +  D+  ++IW+VS+G+ L        +    H  +V    F+P   +++S      ++
Sbjct: 103  VSASDDKTLKIWDVSSGKCL--------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154

Query: 1158 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQT 1203
             W+V TG+  +T   +   +  +H + D    V+    G+  I  T
Sbjct: 155  IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  115 bits (287), Expect = 3e-25
 Identities = 82/304 (26%), Positives = 150/304 (49%), Gaps = 30/304 (9%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           HT AV    FS +G+ +AS  ADK ++++ A  G+    I  H+  +   A+S+D   + 
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           + S DK +KIW+  +G+ + T   HS  V CC+F   S+  L+ +GS D  +++WD+   
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTG 161

Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793
           +C  T+  H++ V+   F+ D  L+ S S DG  ++WD  S    K++        ++D 
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDD 213

Query: 794 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVM--FSPD 850
              +  +     +S +G  I+ A   N + LW+      +    GH +  + +   FS  
Sbjct: 214 NPPVSFV----KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269

Query: 851 GSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAVDHIR 901
           G  ++ S S+D  + +W  +TK++ +     L+   DVV        EN +   A+++ +
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISTACHPTENIIASAALENDK 325

Query: 902 RLQL 905
            ++L
Sbjct: 326 TIKL 329



 Score =  114 bits (284), Expect = 7e-25
 Identities = 68/260 (26%), Positives = 121/260 (46%), Gaps = 18/260 (6%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H   +    +S D   + S   DKTL+++   +G+ L  +K H + V CC F+     I 
Sbjct: 86  HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           + S D+ V+IW+  TG+ + T   HS+ V+  HF       L+ + S D   ++WD    
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS--LIVSSSYDGLCRIWDTASG 203

Query: 734 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792
           +C  T+    N  V+  +FSP+ K + + + D TLKLWD +     K+            
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---------- 253

Query: 793 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLWNTDSRSKVADCRGHLSWVHGVMFSPD 850
                E      ++S  G + +V+    N +++WN  ++  V   +GH   V      P 
Sbjct: 254 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312

Query: 851 GSSFLTSS--DDQTIRLWET 868
            +   +++  +D+TI+LW++
Sbjct: 313 ENIIASAALENDKTIKLWKS 332



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 61/223 (27%), Positives = 112/223 (50%), Gaps = 23/223 (10%)

Query: 653 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 712
           +  H   V    FS +  ++A+ S DK +KIW +  G+   T   H   ++   +++ S+
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 713 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 772
             LL + S D  LK+WD++  +C  T+ GH+N V  C F+P   L+ S S D ++++WD 
Sbjct: 101 --LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158

Query: 773 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDS--- 828
            +    K++          DP       V    ++ DG+ I+ ++ + +  +W+T S   
Sbjct: 159 KTGKCLKTLPAH------SDP-------VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205

Query: 829 -RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 870
            ++ + D    +S+   V FSP+G   L ++ D T++LW+  K
Sbjct: 206 LKTLIDDDNPPVSF---VKFSPNGKYILAATLDNTLKLWDYSK 245



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 74/345 (21%), Positives = 150/345 (43%), Gaps = 61/345 (17%)

Query: 738  TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797
            T+ GHT +V+  +FSP+ + LAS SAD  +K+W A      K+I+  +  L + D     
Sbjct: 40   TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK--LGISD----- 92

Query: 798  EVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLT 856
                   +WS+D   ++ A+ +K + +W+  S   +   +GH ++V    F+P  +  ++
Sbjct: 93   ------VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146

Query: 857  SSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 914
             S D+++R+W+ K  K  K           V F  +  ++++  +    ++ +  +GQ  
Sbjct: 147  GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ-- 204

Query: 915  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 974
                      CL   +      D+N  +                       ++F+ + K 
Sbjct: 205  ----------CLKTLID-----DDNPPVSF---------------------VKFSPNGKY 228

Query: 975  LISSSDDAEIQVWNWQLDKCI-FLRGHQE----TVKDFRLLKNSRLLSWSFDGTVKVWNI 1029
            +++++ D  +++W++   KC+    GH+        +F +     ++S S D  V +WN+
Sbjct: 229  ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288

Query: 1030 ITGNKEKDFVCHQGTVLS--CDISHDATKFSSTSADKTAKIWSFD 1072
             T    +    H   V+S  C  + +    ++   DKT K+W  D
Sbjct: 289  QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 11/176 (6%)

Query: 997  LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDAT 1055
            L GH + V   +   N   L S S D  +K+W    G  EK    H+  +     S D+ 
Sbjct: 41   LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 1056 KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1115
               S S DKT KIW       L  L+GH+  V C  F+  S L+ +G  +  +RIW+V  
Sbjct: 101  LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160

Query: 1116 GELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQT 1169
            G+ L      S+  +A H        F+ DG +++S+   G  + W+  +G+  +T
Sbjct: 161  GKCLKTLPAHSDPVSAVH--------FNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 46/166 (27%), Positives = 85/166 (51%), Gaps = 8/166 (4%)

Query: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
           ++ H++ V+   F+     I S   D++++++  +TG+ L  + AH D V    F+ D  
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184

Query: 671 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
            I + S D   +IW++ +G+ + T  D+ +  V+   F+ +  ++L AT   D  LKLWD
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWD 242

Query: 730 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 771
            ++ +C  T  GH N   +C F+       K + S S D  + +W+
Sbjct: 243 YSKGKCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 287



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 59/291 (20%), Positives = 123/291 (42%), Gaps = 19/291 (6%)

Query: 837  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLW-----ETKKVCKNSAVMLKQEVDVVFQENE 891
            GH   V  V FSP+G    +SS D+ I++W     + +K      + +    DV +  + 
Sbjct: 43   GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS---DVAWSSDS 99

Query: 892  VMVLAVDHIRRLQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELV 948
             ++++    + L++ +  +G+     +     V CC  +P    I  G  + ++ I ++ 
Sbjct: 100  NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159

Query: 949  NNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI--FLRGHQETVKD 1006
              +  ++   H   V  + F  D   ++SSS D   ++W+    +C+   +      V  
Sbjct: 160  TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219

Query: 1007 FRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATK---FSSTSA 1062
             +   N + +L+ + D T+K+W+   G   K +  H+        +   T      S S 
Sbjct: 220  VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279

Query: 1063 DKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG--DDNGEIRIW 1111
            D    IW+      + +L+GH   V  +A      ++A+   +++  I++W
Sbjct: 280  DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 12/166 (7%)

Query: 1041 HQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGCVRCSAFSVDSTLL 1099
            H   V S   S +    +S+SADK  KIW ++D       + GH   +   A+S DS LL
Sbjct: 44   HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNLL 102

Query: 1100 ATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1157
             +  D+  ++IW+VS+G+ L        +    H  +V    F+P   +++S      ++
Sbjct: 103  VSASDDKTLKIWDVSSGKCL--------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154

Query: 1158 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQT 1203
             W+V TG+  +T   +   +  +H + D    V+    G+  I  T
Sbjct: 155  IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  105 bits (262), Expect = 3e-22
 Identities = 68/256 (26%), Positives = 111/256 (43%), Gaps = 16/256 (6%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H D V    FS  G  +AS   D+T++++  +   K  E KAH   V    FS D +F+A
Sbjct: 59  HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLA 118

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           T S DK +K+W+      +++   H+  V C  F+      L+ + S D  +K+WD   K
Sbjct: 119 TASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR--LIVSCSEDKTIKIWDTTNK 176

Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793
           +C N         N   F+P    +AS  +D T+K+WD         + V +   + +  
Sbjct: 177 QCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD---------VRVNKLLQHYQVH 227

Query: 794 QEDMEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGS 852
                  V C S+   G  ++ A+ +  + + +      +   +GH   V  V FS  G 
Sbjct: 228 SGG----VNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGE 283

Query: 853 SFLTSSDDQTIRLWET 868
            F +   D  + LW T
Sbjct: 284 LFASGGADTQVLLWRT 299



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 71/286 (24%), Positives = 124/286 (43%), Gaps = 23/286 (8%)

Query: 716 LATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 775
           LAT S D FL LW+           GH + V   +FSP   LLAS S D T++LW     
Sbjct: 33  LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKR 92

Query: 776 NERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVAD 834
            +                       V+   +SADG  +  A+++K I +W+   +  +  
Sbjct: 93  GKFSEFKAH-------------TAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYS 139

Query: 835 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNS---AVMLKQEVDVVFQEN 890
              H  WV    FSPDG   ++ S+D+TI++W+ T K C N+   +V     VD  F  +
Sbjct: 140 LYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD--FNPS 197

Query: 891 EVMVLAVDHIRRLQLINGRTGQI---DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILEL 947
              + +    + +++ + R  ++     +    V+C    P   Y+     +G ++IL+L
Sbjct: 198 GTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDL 257

Query: 948 VNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDK 993
           +  R+  +   H   V+ + F+   +   S   D ++ +W    D+
Sbjct: 258 LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDE 303



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 61/253 (24%), Positives = 114/253 (45%), Gaps = 16/253 (6%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H  A+     S +G+++A+   D  L ++  +   +      H+D V    FS     +A
Sbjct: 17  HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           + S D+ V++W          +  H+  V    F  S+    LAT S D  +K+W + ++
Sbjct: 77  SASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF--SADGQFLATASEDKSIKVWSMYRQ 134

Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793
               +++ HT+ V   +FSPD +L+ SCS D T+K+WD T+     + +    F N  D 
Sbjct: 135 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD- 193

Query: 794 QEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGS 852
                       ++  G  I  A  ++ + +W+      +   + H   V+ + F P G+
Sbjct: 194 ------------FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241

Query: 853 SFLTSSDDQTIRL 865
             +T+S D T+++
Sbjct: 242 YLITASSDGTLKI 254



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 67/251 (26%), Positives = 114/251 (45%), Gaps = 12/251 (4%)

Query: 959  HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR-GHQETVKDFRLLKNSRLL- 1016
            HK  +  +  + + K L ++S D  + +WN++     +   GH++ V   +   +  LL 
Sbjct: 17   HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76

Query: 1017 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1076
            S S D TV++W      K  +F  H   V S D S D    ++ S DK+ K+WS      
Sbjct: 77   SASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRF 136

Query: 1077 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1136
            L+ L  H   VRC+ FS D  L+ +  ++  I+IW+ +N + ++          +   G+
Sbjct: 137  LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN--------NFSDSVGF 188

Query: 1137 VTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1194
               + F+P G  + SAG    +K W+V   +  Q +  +   +  I   P     +T  +
Sbjct: 189  ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASS 248

Query: 1195 LGILYILQTLE 1205
             G L IL  LE
Sbjct: 249  DGTLKILDLLE 259



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 51/160 (31%), Positives = 77/160 (48%), Gaps = 2/160 (1%)

Query: 612 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 671
           + HT  V    FS DGQ +A+   DK+++V+       L  +  H   V C  FS D R 
Sbjct: 99  KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRL 158

Query: 672 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731
           I +CS DK +KIW++   + V+ + +     N   F  S     +A+  SD  +K+WD+ 
Sbjct: 159 IVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSG--TCIASAGSDQTVKVWDVR 216

Query: 732 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
             +       H+  VN   F P    L + S+DGTLK+ D
Sbjct: 217 VNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILD 256



 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 80/350 (22%), Positives = 135/350 (38%), Gaps = 50/350 (14%)

Query: 836  RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVL 895
            +GH + +  +  SP+G    T+S D  + LW  K                          
Sbjct: 15   KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKP------------------------- 49

Query: 896  AVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQS 955
               H R  + +    G  D +T  Q      SPH   +A    +  + +        F  
Sbjct: 50   ---HARAYRYV----GHKDVVTSVQ-----FSPHGNLLASASRDRTVRLWIPDKRGKFSE 97

Query: 956  RFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1014
               H   V  + F+AD + L ++S+D  I+VW+    + ++ L  H   V+  +   + R
Sbjct: 98   FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR 157

Query: 1015 LL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1073
            L+ S S D T+K+W+        +F    G     D +   T  +S  +D+T K+W   +
Sbjct: 158  LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRV 217

Query: 1074 LLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATH 1133
               L   + H+G V C +F      L T   +G ++I ++  G L++            H
Sbjct: 218  NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT--------LQGH 269

Query: 1134 GGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIH 1181
             G V  + FS  G++  S G    +  W     E      T   NLK++H
Sbjct: 270  TGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTK-RNLKRLH 318



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 33/112 (29%), Positives = 54/112 (48%), Gaps = 2/112 (1%)

Query: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
           F+  G  IAS G+D+T++V+     + L   + H   V C +F     ++ T S D  +K
Sbjct: 194 FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253

Query: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE 734
           I + + G L++T   H+  V    F+      L A+G +D  + LW  N  E
Sbjct: 254 ILDLLEGRLIYTLQGHTGPVFTVSFSKGGE--LFASGGADTQVLLWRTNFDE 303



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 38/180 (21%), Positives = 62/180 (34%), Gaps = 52/180 (28%)

Query: 1035 EKDFVCHQGTVLSCDISHDATK-------------------------------------- 1056
            E+ F  H+  + S D+S +  +                                      
Sbjct: 11   ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70

Query: 1057 ----FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1112
                 +S S D+T ++W  D      E + H   VR   FS D   LAT  ++  I++W+
Sbjct: 71   HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130

Query: 1113 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1170
            +     L+            H  WV    FSPDG++++S      IK W+    +    F
Sbjct: 131  MYRQRFLY--------SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF 182



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 23/101 (22%), Positives = 39/101 (38%), Gaps = 1/101 (0%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H+  V    F   G  + +  +D TL++     G  +  ++ H   V   +FS      A
Sbjct: 227 HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFA 286

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 714
           +   D +V +W +   EL H        +   HF +  H L
Sbjct: 287 SGGADTQVLLWRTNFDEL-HCKGLTKRNLKRLHFDSPPHLL 326


>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
          Length = 2627

 Score =  105 bits (261), Expect = 3e-22
 Identities = 185/805 (22%), Positives = 300/805 (37%), Gaps = 175/805 (21%)

Query: 487  LAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEY-------RHILDEKDCA 539
            L YH+  +     L   + +L  + A  EL   + L+     Y          L E D A
Sbjct: 1545 LPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVA 1604

Query: 540  VSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWIN 599
            V   F+ FL     +L + P   + Q    +P  S +  QA L +++   +    L W+N
Sbjct: 1605 V---FRTFLRQQASILSQYP-RLLPQQAANQPLDSPLCHQASLLSRRW--HLQHTLRWLN 1658

Query: 600  K----KNITNLS-RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654
            K    KN  + S  L V     AV    FS +GQR A   A+ T+ +    T ++   + 
Sbjct: 1659 KPRTMKNQQSSSLSLAVSSSPTAV---AFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVV 1715

Query: 655  AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 714
            +  D +  C F +DD    T + D  +++W+   G  V     H  Q+  C  +      
Sbjct: 1716 SGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCR-- 1772

Query: 715  LLATGSSDCFLKLWDLNQKECRNTMFGHT--NSVNHCRFSPDDKLLASCSADGTLKLWDA 772
            LLAT      LKLWD  + +     F HT   S+N   F P+ +++A+ S  G++  +  
Sbjct: 1773 LLATVCLGGCLKLWDTVRGQLA---FQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQV 1829

Query: 773  TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSK 831
                  K +                   ++  +++  G  + V   + +  LW     ++
Sbjct: 1830 DGLKVTKDLGAPG-------------ASIRTLAFNVPGGVVAVGRLDSMVELWAWREGAR 1876

Query: 832  VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNS---AVMLKQEVDVVFQ 888
            +A    H  +V   +F   G   LT+ +D  +++W            ++ L   + V   
Sbjct: 1877 LAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALS 1936

Query: 889  ENEVMVLA---VDHIRRLQLINGRTGQIDYLTEAQVSCCC-LSPHLQYIAFGDENGAIEI 944
             +   V      D IR  ++ +G  G      +  VS    LSP +  +  G E+G+++ 
Sbjct: 1937 PDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKV--LVSGAEDGSLQG 1994

Query: 945  LEL----VNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL--------- 991
              L    + +    SRFQ  K V  +     ++ L S+S+D  +Q+W  QL         
Sbjct: 1995 WALKECSLQSLWLLSRFQ--KPV--LGLATSQELLASASEDFTVQLWPRQLLTRPHKAED 2050

Query: 992  DKC-IFLRGHQETV----------------KDFRLL------------------------ 1010
              C   LRGH+  V                +D  LL                        
Sbjct: 2051 FPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWV 2110

Query: 1011 ------KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVL------------------ 1046
                  K++ L+S S DG+V +W+  +G +   F+ HQ  V                   
Sbjct: 2111 TGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTL 2170

Query: 1047 ----------------SCDISHDATKFSSTSA--------------DKTAKIWSFDLLLP 1076
                            S  ISH A      +A              D   ++W   L+  
Sbjct: 2171 KVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQ 2230

Query: 1077 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1136
             H L GH+G VR +A S  S L+ T  ++G +R+W V   E    C P S          
Sbjct: 2231 THTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPK-EADDTCIPRSSAA------- 2282

Query: 1137 VTDLCFSPDGKMLIS---AGGYIKW 1158
            VT + ++PDG M +S   AG  I W
Sbjct: 2283 VTAVAWAPDGSMAVSGNQAGELILW 2307



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 67/323 (20%), Positives = 127/323 (39%), Gaps = 37/323 (11%)

Query: 614  HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
            H D V    +++D   I SC +D ++ ++  E+G++L +   H+  V   A +  +  + 
Sbjct: 2106 HRDWVTGCAWTKDNLLI-SCSSDGSVGLWDPESGQRLGQFLGHQSAV--SAVAAVEEHVV 2162

Query: 674  TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT-------NSSHHLLLATGSSDCFLK 726
            + S D  +K+W+    EL  +   HS  ++ C               LL+ T   D   +
Sbjct: 2163 SVSRDGTLKVWDHQGVELT-SIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATR 2221

Query: 727  LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQF 786
            LW        +T+ GH+  V     S    L+ + S DG+++LW      +   I     
Sbjct: 2222 LWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCI----- 2276

Query: 787  FLNLEDPQEDMEVIVKCCSWSADGARIMVAAK-NKIFLWNTDSRSKVADCRGHLSWVHGV 845
                  P+      V   +W+ DG+  +   +  ++ LW        A   GH+    G 
Sbjct: 2277 ------PRS--SAAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHI----GA 2324

Query: 846  MFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQL 905
            +      +F   S D+ I  W+ K    ++   L   ++ + QE+  ++ ++D       
Sbjct: 2325 LIWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDW------ 2378

Query: 906  INGRTGQIDYLTEAQVSCCCLSP 928
                 G    L +A +   C+ P
Sbjct: 2379 --APDGHFLILAKADLKLLCMKP 2399


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  104 bits (260), Expect = 4e-22
 Identities = 63/254 (24%), Positives = 106/254 (41%), Gaps = 12/254 (4%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H   V  + FS DGQ + +   D  +  ++  +G+ L  +  H   V  C FS D    A
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           + S D  V++W+    + +     H   V    F+  S    LA+G  D  + LWD+   
Sbjct: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ--LASGGWDKRVMLWDVQSG 137

Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793
           +    + GH +S+    FSP    LA+ S D T+ +WD        S             
Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVS----------HQA 187

Query: 794 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 853
            E     + C  +SA G     +    I +W   + S +   +GH++WV  + FSPD   
Sbjct: 188 LEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELW 247

Query: 854 FLTSSDDQTIRLWE 867
             ++   + +++W+
Sbjct: 248 LASAGYSRMVKVWD 261



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 74/257 (28%), Positives = 120/257 (46%), Gaps = 16/257 (6%)

Query: 920  QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 979
            +V+    SP  Q +  G E+G +   E  + ++      H   V   +F+ D     S+S
Sbjct: 23   EVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASAS 82

Query: 980  DDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKD 1037
             D  +++W+    KC+  L+GHQ +V+      +SR L S  +D  V +W++ +G   + 
Sbjct: 83   CDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRL 142

Query: 1038 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL---HELRGHNGCVRCSAFSV 1094
             V H+ ++ S D S      ++ S D T  IW   ++ P      L GH+  + C  +S 
Sbjct: 143  LVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA 202

Query: 1095 DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG- 1153
             S LLA+G  +  I IW  +   LL     +  +G   H  WV  + FSPD   L SAG 
Sbjct: 203  -SGLLASGSWDKTIHIWKPTTSSLL-----IQLKG---HVTWVKSIAFSPDELWLASAGY 253

Query: 1154 -GYIKWWNVVTGESSQT 1169
               +K W+  TG+  +T
Sbjct: 254  SRMVKVWDCNTGKCLET 270



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 66/255 (25%), Positives = 117/255 (45%), Gaps = 20/255 (7%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           HT  V    FS DG   AS   D T++++     + L  +K H+  V   +FS D R +A
Sbjct: 62  HTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLA 121

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ- 732
           +   DK+V +W+  +G+++     H + +    F+ + +   LATGS D  + +WDL   
Sbjct: 122 SGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVN--CLATGSWDSTVHIWDLRMV 179

Query: 733 --KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 790
                   + GH+ +++ C       LLAS S D T+ +W  T++             +L
Sbjct: 180 TPAVSHQALEGHSANIS-CLCYSASGLLASGSWDKTIHIWKPTTS-------------SL 225

Query: 791 EDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSP 849
               +     VK  ++S D   +  A  ++ + +W+ ++   +   +G L   H   F+P
Sbjct: 226 LIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTP 285

Query: 850 DGSSFLTSSDDQTIR 864
           DG   ++ + DQT R
Sbjct: 286 DGKILVSGAADQTRR 300



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 76/320 (23%), Positives = 133/320 (41%), Gaps = 53/320 (16%)

Query: 838  HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 897
            H   V+   FSPDG   LT S+D  +  WET+                            
Sbjct: 20   HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSG-------------------------- 53

Query: 898  DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 957
               + L  + G TG + +        C  SP     A    +  + + ++   +  +   
Sbjct: 54   ---QLLWRLGGHTGPVKF--------CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLK 102

Query: 958  QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVK--DFRLLKNSR 1014
             H+++V  + F+ D + L S   D  + +W+ Q  + +  L GH+++++  DF    N  
Sbjct: 103  GHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNC- 161

Query: 1015 LLSWSFDGTVKVWNI--ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1072
            L + S+D TV +W++  +T       +      +SC     +   +S S DKT  IW   
Sbjct: 162  LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPT 221

Query: 1073 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1132
                L +L+GH   V+  AFS D   LA+   +  +++W+ + G+ L     + +     
Sbjct: 222  TSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLD----- 276

Query: 1133 HGGWVTDLC-FSPDGKMLIS 1151
                V   C F+PDGK+L+S
Sbjct: 277  ----VAHTCAFTPDGKILVS 292



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 50/168 (29%), Positives = 81/168 (48%), Gaps = 6/168 (3%)

Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
           V++ H  +V    FS D +++AS G DK + ++  ++G+ L  +  H D +    FS   
Sbjct: 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTV 159

Query: 670 RFIATCSVDKKVKIWN--SMTGELVH-TYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 726
             +AT S D  V IW+   +T  + H   + HS  ++C  ++ S    LLA+GS D  + 
Sbjct: 160 NCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG---LLASGSWDKTIH 216

Query: 727 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATS 774
           +W          + GH   V    FSPD+  LAS      +K+WD  +
Sbjct: 217 IWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNT 264



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 62/233 (26%), Positives = 101/233 (43%), Gaps = 12/233 (5%)

Query: 958  QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL 1016
            QH   V    F+ D + L++ S+D  +  W  +  + ++ L GH   VK  R   +  L 
Sbjct: 19   QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78

Query: 1017 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLL 1075
             S S D TV++W++      +    HQ +V +   S D+ + +S   DK   +W      
Sbjct: 79   ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138

Query: 1076 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGG 1135
             L  L GH   ++ S FS     LATG  +  + IW     +L  +   +S +    H  
Sbjct: 139  MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW-----DLRMVTPAVSHQALEGHSA 193

Query: 1136 WVTDLCFSPDGKMLISAGGY---IKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1185
             ++ LC+S  G  L+++G +   I  W   T         + T +K I  SPD
Sbjct: 194  NISCLCYSASG--LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 60/307 (19%), Positives = 119/307 (38%), Gaps = 42/307 (13%)

Query: 801  VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 859
            V   ++S DG  ++  +++  ++ W T S   +    GH   V    FSPDG  F ++S 
Sbjct: 24   VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASC 83

Query: 860  DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 919
            D T+RLW+  +                              + L+++ G    ++ ++  
Sbjct: 84   DCTVRLWDVARA-----------------------------KCLRVLKGHQRSVETVS-- 112

Query: 920  QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 979
                   SP  + +A G  +  + + ++ + ++ +    H+ ++    F+     L + S
Sbjct: 113  ------FSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGS 166

Query: 980  DDAEIQVWNWQLDKCIF----LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKE 1035
             D+ + +W+ ++         L GH   +       +  L S S+D T+ +W   T +  
Sbjct: 167  WDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLL 226

Query: 1036 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1095
                 H   V S   S D    +S    +  K+W  +    L  L+G        AF+ D
Sbjct: 227  IQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPD 286

Query: 1096 STLLATG 1102
              +L +G
Sbjct: 287  GKILVSG 293



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 41/158 (25%), Positives = 62/158 (39%), Gaps = 10/158 (6%)

Query: 1036 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1095
            K F  H G V S   S D     + S D     W       L  L GH G V+   FS D
Sbjct: 15   KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74

Query: 1096 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG-- 1153
              L A+   +  +R+W+V+  + L +           H   V  + FSPD + L S G  
Sbjct: 75   GHLFASASCDCTVRLWDVARAKCLRV--------LKGHQRSVETVSFSPDSRQLASGGWD 126

Query: 1154 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1191
              +  W+V +G+  +    +  +++    SP      T
Sbjct: 127  KRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLAT 164



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 21/79 (26%), Positives = 38/79 (48%)

Query: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660
           K  T+   + ++ H   V    FS D   +AS G  + ++V+   TG+ L  +K   D  
Sbjct: 219 KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVA 278

Query: 661 LCCAFSTDDRFIATCSVDK 679
             CAF+ D + + + + D+
Sbjct: 279 HTCAFTPDGKILVSGAADQ 297


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score =  103 bits (258), Expect = 8e-22
 Identities = 81/274 (29%), Positives = 125/274 (45%), Gaps = 20/274 (7%)

Query: 915  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 974
            Y TE  ++   +SP  + +A G +N  I++  L + ++      H+  V  I    D   
Sbjct: 265  YNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLACD--- 319

Query: 975  LISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGN 1033
            ++   DD +         +   LRGH   V   R L +S  LLS S D +++ W++ +  
Sbjct: 320  ILEEEDDEDDNAGT----EMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT 375

Query: 1034 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1093
                +  H   V   DIS  +  F+S S D+TA++WSFD   PL    GH   V C  F 
Sbjct: 376  NTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH 435

Query: 1094 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1153
             +S  LATG  +  +R+W+   G  + L           H G V  L FSP+GK L SAG
Sbjct: 436  PNSNYLATGSTDKTVRLWSAQQGNSVRL--------FTGHRGPVLSLAFSPNGKYLASAG 487

Query: 1154 --GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1185
                +K W++ +G   +    +  N+  +  SPD
Sbjct: 488  EDQRLKLWDLASGTLYKELRGHTDNITSLTFSPD 521



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 2/158 (1%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H   V+    S      AS   D+T +++  +    L     H  +V C  F  +  ++A
Sbjct: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           T S DK V++W++  G  V  +  H   V    F+ +  +L  A+   D  LKLWDL   
Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL--ASAGEDQRLKLWDLASG 500

Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
                + GHT+++    FSPD  L+AS S D ++++WD
Sbjct: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 65/267 (24%), Positives = 113/267 (42%), Gaps = 18/267 (6%)

Query: 647 GEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCH 706
           G ++  ++ H   V    F  D   + +CS D  ++ W+  +      Y  H+  V    
Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV--WD 389

Query: 707 FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGT 766
              S + L  A+GS D   +LW  ++        GH   V+  +F P+   LA+ S D T
Sbjct: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449

Query: 767 LKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWN 825
           ++LW A   N  +       F     P       V   ++S +G  +  A ++ ++ LW+
Sbjct: 450 VRLWSAQQGNSVR------LFTGHRGP-------VLSLAFSPNGKYLASAGEDQRLKLWD 496

Query: 826 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVD 884
             S +   + RGH   +  + FSPD     ++S D ++R+W+ +   C   A     E+ 
Sbjct: 497 LASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELV 556

Query: 885 VVFQENEVMVLAVDHIR-RLQLINGRT 910
            V+      VL+V  +   L L+ G T
Sbjct: 557 GVYTGQMSNVLSVQFMACNLLLVTGIT 583



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 49/172 (28%), Positives = 75/172 (43%), Gaps = 2/172 (1%)

Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
           ++R H   VY   F  D   + SC  D +++ +   +    +  + H   V     S   
Sbjct: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS 396

Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
            + A+ S D+  ++W+      +  Y  H   V+C  F  +S++L  ATGS+D  ++LW 
Sbjct: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYL--ATGSTDKTVRLWS 454

Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSI 781
             Q        GH   V    FSP+ K LAS   D  LKLWD  S    K +
Sbjct: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506



 Score = 73.9 bits (180), Expect = 8e-13
 Identities = 67/279 (24%), Positives = 113/279 (40%), Gaps = 25/279 (8%)

Query: 848  SPDGSSFLTSSDDQTIRLWETKKVCKNS------AVMLKQEVDVVFQENEVMVLAVDHIR 901
            SPD        D+  I+LW  +     S         +    D++ +E++    A   ++
Sbjct: 277  SPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMK 336

Query: 902  RLQLINGRTGQIDYLTEAQ-VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 960
             L+   G      +L ++  +  C     ++Y   G            N  ++Q    H 
Sbjct: 337  ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS---------FTNTVLYQG---HA 384

Query: 961  KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNSRLLS 1017
              VW +  +       S S D   ++W++  D+   LR   GH   V   +   NS  L+
Sbjct: 385  YPVWDLDISPYSLYFASGSHDRTARLWSF--DRTYPLRIYAGHLADVDCVKFHPNSNYLA 442

Query: 1018 W-SFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1076
              S D TV++W+   GN  + F  H+G VLS   S +    +S   D+  K+W       
Sbjct: 443  TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTL 502

Query: 1077 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1115
              ELRGH   +    FS DS L+A+   +  +R+W++ N
Sbjct: 503  YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 68/312 (21%), Positives = 113/312 (36%), Gaps = 81/312 (25%)

Query: 715 LLATGSSDCFLKLWDLNQKECRNT--------------------------------MFGH 742
           LLA G  +  +KLW L  K+ ++                                 + GH
Sbjct: 282 LLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGH 341

Query: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVK 802
              V   RF  D   L SCS D +++ WD  S           +      P  D++ I  
Sbjct: 342 CGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAY------PVWDLD-ISP 394

Query: 803 CCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQT 862
              + A G+    A      LW+ D    +    GHL+ V  V F P+ +   T S D+T
Sbjct: 395 YSLYFASGSHDRTAR-----LWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449

Query: 863 IRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVS 922
           +RLW  +                  Q N V           +L  G  G +  L      
Sbjct: 450 VRLWSAQ------------------QGNSV-----------RLFTGHRGPVLSLA----- 475

Query: 923 CCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDA 982
               SP+ +Y+A   E+  +++ +L +  +++    H   +  + F+ D   + S+S D 
Sbjct: 476 ---FSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDN 532

Query: 983 EIQVWNWQLDKC 994
            ++VW+ +   C
Sbjct: 533 SVRVWDIRNTYC 544



 Score = 53.9 bits (128), Expect = 9e-07
 Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 13/117 (11%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H   V    FS +G+ +AS G D+ L+++   +G    E++ H D +    FS D   IA
Sbjct: 467 HRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIA 526

Query: 674 TCSVDKKVKIW-----------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 719
           + S+D  V++W           +  + ELV  Y      V    F   + +LLL TG
Sbjct: 527 SASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQF--MACNLLLVTG 581


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score =  103 bits (258), Expect = 8e-22
 Identities = 100/400 (25%), Positives = 167/400 (41%), Gaps = 45/400 (11%)

Query: 735  CRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQ 794
            C +++ GH+ +V    FSP  K LAS S D T++ WD ++     +    + +       
Sbjct: 106  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHW------- 158

Query: 795  EDMEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVA-DCRGHLSWVHGVMF----- 847
                  V   SWS DG ++    KN +I LW+  +  +V     GH  W+ G+ +     
Sbjct: 159  ------VLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHA 212

Query: 848  SPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLI 906
            +P+     +SS D ++R+W+T    C+       Q V  +    + ++ +    R +++ 
Sbjct: 213  NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVW 272

Query: 907  NGRTGQIDYLTEAQVSCCCLSPHLQYIA-------FGDENGAIEILEL-VNNRIFQSRFQ 958
                G         V C  L  H  ++        +    GA E  E  VN +  Q   Q
Sbjct: 273  RAHDG---------VLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQ 323

Query: 959  HKK----TVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR--GHQETVKDFRLLKN 1012
              K    + +++      + L+S SDD  + +W+   DK    R  GHQ  +       +
Sbjct: 324  ELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD 383

Query: 1013 SRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1071
            SR++ S SFD ++K+W+  TG        H   V     S D+    S S+D T K+W  
Sbjct: 384  SRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443

Query: 1072 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1111
                   +L GH   V    +S D   +A+G  +  +RIW
Sbjct: 444  KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 72/291 (24%), Positives = 128/291 (43%), Gaps = 40/291 (13%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H++AV    FS  G+ +AS   D T++ +   T       K H   VL  ++S D R +A
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172

Query: 674 TCSVDKKVKIWNSMTGELV-HTYDEHSEQVNCCHFT---NSSHHLLLATGSSDCFLKLWD 729
           +   + ++ +W+  TG+ V  T   HS+ +    +     +     +A+ S D  +++WD
Sbjct: 173 SGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232

Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA----------------- 772
                C   + GHT SV   R+   D LL S S D T+K+W A                 
Sbjct: 233 TTAGRCERILTGHTQSVTCLRWG-GDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVN 291

Query: 773 -----------TSANE--RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN 819
                      T A E    S+N +    +L++ +E    + +       G   +V+  +
Sbjct: 292 TMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKE--RALSRYNLVRGQGPERLVSGSD 349

Query: 820 --KIFLWN-TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867
              +FLW+  + +  +    GH + ++ V+FSPD     ++S D++I+LW+
Sbjct: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 65/280 (23%), Positives = 111/280 (39%), Gaps = 58/280 (20%)

Query: 630 IASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTG 689
           +AS   D +++++    G     +  H   V C  +  D   + + S D+ +K+W +  G
Sbjct: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDG 277

Query: 690 ELVHTYDEHSEQVNCCHFTN---------------------------------SSHHLL- 715
            L  T   H   VN    +                                  S ++L+ 
Sbjct: 278 VLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVR 337

Query: 716 ------LATGSSDCFLKLWD-LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLK 768
                 L +GS D  L LW     K+    M GH   +N   FSPD +++AS S D ++K
Sbjct: 338 GQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIK 397

Query: 769 LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV--AAKNKIFLWNT 826
           LWD  +     S+                   V   +WSAD +R++V  ++ + + +W+ 
Sbjct: 398 LWDGRTGKYLASL-------------RGHVAAVYQIAWSAD-SRLLVSGSSDSTLKVWDV 443

Query: 827 DSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLW 866
            ++    D  GH   V+ V +SPDG    +   D+ +R+W
Sbjct: 444 KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 46/153 (30%), Positives = 78/153 (50%), Gaps = 3/153 (1%)

Query: 619 YHACFSEDGQRIASCGADKTLQVFK-AETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 677
           Y+    +  +R+ S   D TL ++  AE  + L  +  H+  +    FS D R +A+ S 
Sbjct: 333 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 392

Query: 678 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 737
           DK +K+W+  TG+ + +   H   V    ++  S   LL +GSSD  LK+WD+  ++   
Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSR--LLVSGSSDSTLKVWDVKAQKLAM 450

Query: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770
            + GH + V    +SPD + +AS   D  L++W
Sbjct: 451 DLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 32/130 (24%), Positives = 63/130 (48%), Gaps = 7/130 (5%)

Query: 599 NKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHED 658
           +KK +T ++      H   +    FS D + +AS   DK+++++   TG+ L  ++ H  
Sbjct: 361 DKKPLTRMTG-----HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVA 415

Query: 659 EVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLAT 718
            V   A+S D R + + S D  +K+W+    +L      H+++V    ++       +A+
Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQR--VAS 473

Query: 719 GSSDCFLKLW 728
           G  D  L++W
Sbjct: 474 GGKDKCLRIW 483



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 34/131 (25%), Positives = 56/131 (42%), Gaps = 14/131 (10%)

Query: 1041 HQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLA 1100
            H   V+S   S      +S S D T + W      P    +GH   V   ++S D   LA
Sbjct: 113  HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172

Query: 1101 TGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCF-----SPDGKMLISAG-- 1153
            +G  NG+I +W+ S G+ +           A H  W+T L +     +P+ + + S+   
Sbjct: 173  SGCKNGQILLWDPSTGKQV-------GRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225

Query: 1154 GYIKWWNVVTG 1164
            G ++ W+   G
Sbjct: 226  GSVRIWDTTAG 236



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 34/132 (25%), Positives = 56/132 (42%), Gaps = 16/132 (12%)

Query: 1080 LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTD 1139
            L GH+  V   AFS     LA+G  +  +R W++S       C          H  WV  
Sbjct: 110  LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC--------KGHRHWVLS 161

Query: 1140 LCFSPDGKMLISA--GGYIKWWNVVTGE------SSQTFYTNGTNLKKIHVSPDFKTYVT 1191
            + +SPDG+ L S    G I  W+  TG+      +  + +  G + + +H +P+ +   +
Sbjct: 162  ISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVAS 221

Query: 1192 VDNLGILYILQT 1203
                G + I  T
Sbjct: 222  SSKDGSVRIWDT 233



 Score = 35.0 bits (79), Expect = 0.43
 Identities = 15/30 (50%), Positives = 21/30 (70%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFK 643
           H D VY   +S DGQR+AS G DK L++++
Sbjct: 455 HADEVYAVDWSPDGQRVASGGKDKCLRIWR 484


>gi|5174447 guanine nucleotide binding protein (G protein), beta
           polypeptide 2-like 1 [Homo sapiens]
          Length = 317

 Score =  101 bits (252), Expect = 4e-21
 Identities = 79/280 (28%), Positives = 124/280 (44%), Gaps = 20/280 (7%)

Query: 597 WINKKNITN--LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654
           W   ++ TN  + +  +R H+  V     S DGQ   S   D TL+++   TG       
Sbjct: 43  WKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV 102

Query: 655 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTNSSHH 713
            H  +VL  AFS+D+R I + S DK +K+WN++        DE HSE V+C  F+ +S +
Sbjct: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162

Query: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
            ++ +   D  +K+W+L   + +    GHT  +N    SPD  L AS   DG   LWD  
Sbjct: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222

Query: 774 SANERKS------INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTD 827
                 +      IN   F  N           +K   W  +G  I+   K ++   +T 
Sbjct: 223 EGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKI--WDLEGKIIVDELKQEVI--STS 278

Query: 828 SRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867
           S+++   C   L+W      S DG +      D  +R+W+
Sbjct: 279 SKAEPPQCTS-LAW------SADGQTLFAGYTDNLVRVWQ 311



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 60/208 (28%), Positives = 101/208 (48%), Gaps = 22/208 (10%)

Query: 975  LISSSDDAEIQVWNWQLDKCIF------LRGHQETVKDFRLLKNSRL-LSWSFDGTVKVW 1027
            ++S+S D  I +W    D+  +      LRGH   V D  +  + +  LS S+DGT+++W
Sbjct: 31   ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90

Query: 1028 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGC 1086
            ++ TG   + FV H   VLS   S D  +  S S DKT K+W +  +     +   H+  
Sbjct: 91   DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150

Query: 1087 VRCSAFSVDST---LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFS 1143
            V C  FS +S+   +++ G D   +++WN++N +L        +     H G++  +  S
Sbjct: 151  VSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKL--------KTNHIGHTGYLNTVTVS 201

Query: 1144 PDGKMLISAG--GYIKWWNVVTGESSQT 1169
            PDG +  S G  G    W++  G+   T
Sbjct: 202  PDGSLCASGGKDGQAMLWDLNEGKHLYT 229



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 64/256 (25%), Positives = 110/256 (42%), Gaps = 18/256 (7%)

Query: 921  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSD 980
            VS   +S   Q+   G  +G + + +L      +    H K V  + F++D + ++S S 
Sbjct: 66   VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125

Query: 981  DAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSR---LLSWSFDGTVKVWNIITGNK 1034
            D  I++WN  L  C +      H E V   R   NS    ++S  +D  VKVWN+     
Sbjct: 126  DKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184

Query: 1035 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1094
            + + + H G + +  +S D +  +S   D  A +W  +    L+ L G    +    FS 
Sbjct: 185  KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP 243

Query: 1095 DSTLL--ATGDDNGEIRIWNVSNGELL--HLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1150
            +   L  ATG     I+IW++  G+++   L   +    +       T L +S DG+ L 
Sbjct: 244  NRYWLCAATGP---SIKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299

Query: 1151 S--AGGYIKWWNVVTG 1164
            +      ++ W V  G
Sbjct: 300  AGYTDNLVRVWQVTIG 315



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 39/144 (27%), Positives = 59/144 (40%), Gaps = 10/144 (6%)

Query: 732 QKECRNTMFGHTNSVNHCRFSPD-DKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 790
           Q   R T+ GH   V     +P    ++ S S D T+ +W  T   +  +  + Q  L  
Sbjct: 4   QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLT--RDETNYGIPQRALRG 61

Query: 791 EDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFSP 849
                   VI      S+DG   +  +    + LW+  + +      GH   V  V FS 
Sbjct: 62  HSHFVSDVVI------SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115

Query: 850 DGSSFLTSSDDQTIRLWETKKVCK 873
           D    ++ S D+TI+LW T  VCK
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCK 139



 Score = 37.4 bits (85), Expect = 0.087
 Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 10/117 (8%)

Query: 1080 LRGHNGCVRCSAFSV---DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1136
            L+GHNG V   A +    D  L A+ D    I +W ++  E  +    + +     H  +
Sbjct: 11   LKGHNGWVTQIATTPQFPDMILSASRDKT--IIMWKLTRDETNY---GIPQRALRGHSHF 65

Query: 1137 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1191
            V+D+  S DG+  +S    G ++ W++ TG +++ F  +  ++  +  S D +  V+
Sbjct: 66   VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  100 bits (250), Expect = 6e-21
 Identities = 70/251 (27%), Positives = 111/251 (44%), Gaps = 12/251 (4%)

Query: 959  HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL- 1016
            H+  V  + F+ + K L S S D+ + VW+ +     +   GH++ V       +  LL 
Sbjct: 18   HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77

Query: 1017 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1076
            S S D TV++W      +   F  H  TV S     D   F + S DKT K+W+      
Sbjct: 78   SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137

Query: 1077 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1136
            L  L  H   VRC+ FS D  L+ +  D+  +++W+ S+ E +H            HGG+
Sbjct: 138  LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH--------SYCEHGGF 189

Query: 1137 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1194
            VT + F P G  + +AG    +K W+V T    Q +  +   +  +   P     +T  +
Sbjct: 190  VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249

Query: 1195 LGILYILQTLE 1205
               L IL  +E
Sbjct: 250  DSTLKILDLME 260



 Score =  100 bits (249), Expect = 8e-21
 Identities = 78/340 (22%), Positives = 135/340 (39%), Gaps = 53/340 (15%)

Query: 654 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 713
           K H D V C  FS + + +A+ S+D  + +W+       + +  H + V C +F+ S H 
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH- 74

Query: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
            LLA+GS D  +++W  N K        HT +V    F  D +   + S D T+K+W   
Sbjct: 75  -LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--- 130

Query: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKV 832
                 + + ++F  +L          V+C  +S DG  I+ A+ +K + LW+  SR  V
Sbjct: 131 ------ATHRQKFLFSLSQHIN----WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180

Query: 833 ADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEV 892
                H  +V  V F P G+    +  D T+++W+ +                       
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR----------------------- 217

Query: 893 MVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRI 952
                           R  Q   L  A V+     P   Y+     +  ++IL+L+  R+
Sbjct: 218 --------------THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL 263

Query: 953 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 992
             +   H+     + F+   +   S   D ++ VW    D
Sbjct: 264 LYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 303



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 70/254 (27%), Positives = 117/254 (46%), Gaps = 18/254 (7%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H DAV    FS + +++AS   D  L V+  +   +      H+D V C  FS     +A
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77

Query: 674 TCSVDKKVKIW-NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 732
           + S DK V+IW  ++ GE    +  H+  V   HF +     +  T S D  +K+W  ++
Sbjct: 78  SGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHR 134

Query: 733 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792
           ++   ++  H N V   +FSPD +L+ S S D T+KLWD +S     S      F+   D
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 793 PQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDG 851
                        +   G  I  A   N + +W+  +   +   + H + V+G+ F P G
Sbjct: 195 -------------FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241

Query: 852 SSFLTSSDDQTIRL 865
           +  +T+S D T+++
Sbjct: 242 NYLITASSDSTLKI 255



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%)

Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
           V R HT  V    F  DGQ   +   DKT++V+     + L  +  H + V C  FS D 
Sbjct: 98  VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157

Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
           R I + S DK VK+W+  + E VH+Y EH   V    F  S     +A    D  +K+WD
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 215

Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
           +           H+ +VN   F P    L + S+D TLK+ D
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 66/264 (25%), Positives = 110/264 (41%), Gaps = 32/264 (12%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H DAV    FS  G  +AS   DKT++++      +    +AH   V    F +D +   
Sbjct: 60  HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           T S DK VK+W +   + + +  +H   V C  F+      L+ + S D  +KLWD + +
Sbjct: 120 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSR 177

Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793
           EC ++   H   V +  F P    +A+   D T+K+WD      R    ++ + L+    
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV-----RTHRLLQHYQLH---- 228

Query: 794 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVAD---------CRGHLSWVHG 844
                  V   S+   G  ++ A        ++DS  K+ D           GH      
Sbjct: 229 ----SAAVNGLSFHPSGNYLITA--------SSDSTLKILDLMEGRLLYTLHGHQGPATT 276

Query: 845 VMFSPDGSSFLTSSDDQTIRLWET 868
           V FS  G  F +   D+ + +W++
Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWKS 300



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 70/339 (20%), Positives = 135/339 (39%), Gaps = 55/339 (16%)

Query: 741  GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 800
            GH ++V    FS + K LAS S D  L +W        K  +    F   +D        
Sbjct: 17   GHRDAVTCVDFSINTKQLASGSMDSCLMVW------HMKPQSRAYRFTGHKDA------- 63

Query: 801  VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 859
            V C ++S  G  +   +++K + +W  + + +    R H + V  V F  DG SF+T+SD
Sbjct: 64   VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123

Query: 860  DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 919
            D+T+++W T +  +     L Q ++                                   
Sbjct: 124  DKTVKVWATHR--QKFLFSLSQHIN----------------------------------- 146

Query: 920  QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 979
             V C   SP  + I    ++  +++ +  +     S  +H   V ++ F      + ++ 
Sbjct: 147  WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG 206

Query: 980  DDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKD 1037
             D  ++VW+ +  + +   + H   V       +   L++ S D T+K+ +++ G     
Sbjct: 207  MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 266

Query: 1038 FVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1074
               HQG   +   S     F+S  +D+   +W  +FD++
Sbjct: 267  LHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 305



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 71/333 (21%), Positives = 130/333 (39%), Gaps = 47/333 (14%)

Query: 801  VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 859
            V C  +S +  ++   + +  + +W+   +S+     GH   V  V FSP G    + S 
Sbjct: 22   VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81

Query: 860  DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 919
            D+T+R+W            +K E   VF+ +   V +V                 + ++ 
Sbjct: 82   DKTVRIWVPN---------VKGE-STVFRAHTATVRSVH----------------FCSDG 115

Query: 920  QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 979
            Q           ++   D+   +++      +   S  QH   V   +F+ D + ++S+S
Sbjct: 116  Q----------SFVTASDDK-TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164

Query: 980  DDAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEK 1036
            DD  +++W+    +C+      G   T  DF     + + +   D TVKVW++ T    +
Sbjct: 165  DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQ 223

Query: 1037 DFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDS 1096
             +  H   V             + S+D T KI        L+ L GH G     AFS   
Sbjct: 224  HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283

Query: 1097 TLLATGDDNGEIRIWN-----VSNGELLHLCAP 1124
               A+G  + ++ +W      V +GE+  +  P
Sbjct: 284  EYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRP 316



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%)

Query: 921  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 979
            V+C   SP    +A G  +  + I  + N +   + F+ H  TV  + F +D ++ +++S
Sbjct: 64   VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122

Query: 980  DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1037
            DD  ++VW     K +F L  H   V+  +   + RL+ S S D TVK+W+  +      
Sbjct: 123  DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182

Query: 1038 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1097
            +  H G V   D     T  ++   D T K+W       L   + H+  V   +F     
Sbjct: 183  YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242

Query: 1098 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1153
             L T   +  ++I ++  G LL+            H G  T + FS  G+   S G
Sbjct: 243  YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 290



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 40/176 (22%), Positives = 67/176 (38%), Gaps = 36/176 (20%)

Query: 1035 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1094
            E+ F  H+  V   D S +  + +S S D    +W        +   GH   V C  FS 
Sbjct: 12   ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71

Query: 1095 DSTLLATGDDNGEIRIW-------------NVSNGELLHLCA------PLSEE------- 1128
               LLA+G  +  +RIW             + +    +H C+        S++       
Sbjct: 72   SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131

Query: 1129 --------GAATHGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNG 1174
                      + H  WV    FSPDG++++SA     +K W+  + E   ++  +G
Sbjct: 132  THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  100 bits (250), Expect = 6e-21
 Identities = 70/251 (27%), Positives = 111/251 (44%), Gaps = 12/251 (4%)

Query: 959  HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL- 1016
            H+  V  + F+ + K L S S D+ + VW+ +     +   GH++ V       +  LL 
Sbjct: 18   HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77

Query: 1017 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1076
            S S D TV++W      +   F  H  TV S     D   F + S DKT K+W+      
Sbjct: 78   SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137

Query: 1077 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1136
            L  L  H   VRC+ FS D  L+ +  D+  +++W+ S+ E +H            HGG+
Sbjct: 138  LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH--------SYCEHGGF 189

Query: 1137 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1194
            VT + F P G  + +AG    +K W+V T    Q +  +   +  +   P     +T  +
Sbjct: 190  VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249

Query: 1195 LGILYILQTLE 1205
               L IL  +E
Sbjct: 250  DSTLKILDLME 260



 Score =  100 bits (249), Expect = 8e-21
 Identities = 78/340 (22%), Positives = 135/340 (39%), Gaps = 53/340 (15%)

Query: 654 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 713
           K H D V C  FS + + +A+ S+D  + +W+       + +  H + V C +F+ S H 
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH- 74

Query: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
            LLA+GS D  +++W  N K        HT +V    F  D +   + S D T+K+W   
Sbjct: 75  -LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--- 130

Query: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKV 832
                 + + ++F  +L          V+C  +S DG  I+ A+ +K + LW+  SR  V
Sbjct: 131 ------ATHRQKFLFSLSQHIN----WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180

Query: 833 ADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEV 892
                H  +V  V F P G+    +  D T+++W+ +                       
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR----------------------- 217

Query: 893 MVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRI 952
                           R  Q   L  A V+     P   Y+     +  ++IL+L+  R+
Sbjct: 218 --------------THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL 263

Query: 953 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 992
             +   H+     + F+   +   S   D ++ VW    D
Sbjct: 264 LYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 303



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 70/254 (27%), Positives = 117/254 (46%), Gaps = 18/254 (7%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H DAV    FS + +++AS   D  L V+  +   +      H+D V C  FS     +A
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77

Query: 674 TCSVDKKVKIW-NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 732
           + S DK V+IW  ++ GE    +  H+  V   HF +     +  T S D  +K+W  ++
Sbjct: 78  SGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHR 134

Query: 733 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792
           ++   ++  H N V   +FSPD +L+ S S D T+KLWD +S     S      F+   D
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 793 PQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDG 851
                        +   G  I  A   N + +W+  +   +   + H + V+G+ F P G
Sbjct: 195 -------------FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241

Query: 852 SSFLTSSDDQTIRL 865
           +  +T+S D T+++
Sbjct: 242 NYLITASSDSTLKI 255



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%)

Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
           V R HT  V    F  DGQ   +   DKT++V+     + L  +  H + V C  FS D 
Sbjct: 98  VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157

Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
           R I + S DK VK+W+  + E VH+Y EH   V    F  S     +A    D  +K+WD
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 215

Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
           +           H+ +VN   F P    L + S+D TLK+ D
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 66/264 (25%), Positives = 110/264 (41%), Gaps = 32/264 (12%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H DAV    FS  G  +AS   DKT++++      +    +AH   V    F +D +   
Sbjct: 60  HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           T S DK VK+W +   + + +  +H   V C  F+      L+ + S D  +KLWD + +
Sbjct: 120 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSR 177

Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793
           EC ++   H   V +  F P    +A+   D T+K+WD      R    ++ + L+    
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV-----RTHRLLQHYQLH---- 228

Query: 794 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVAD---------CRGHLSWVHG 844
                  V   S+   G  ++ A        ++DS  K+ D           GH      
Sbjct: 229 ----SAAVNGLSFHPSGNYLITA--------SSDSTLKILDLMEGRLLYTLHGHQGPATT 276

Query: 845 VMFSPDGSSFLTSSDDQTIRLWET 868
           V FS  G  F +   D+ + +W++
Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWKS 300



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 70/339 (20%), Positives = 135/339 (39%), Gaps = 55/339 (16%)

Query: 741  GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 800
            GH ++V    FS + K LAS S D  L +W        K  +    F   +D        
Sbjct: 17   GHRDAVTCVDFSINTKQLASGSMDSCLMVW------HMKPQSRAYRFTGHKDA------- 63

Query: 801  VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 859
            V C ++S  G  +   +++K + +W  + + +    R H + V  V F  DG SF+T+SD
Sbjct: 64   VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123

Query: 860  DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 919
            D+T+++W T +  +     L Q ++                                   
Sbjct: 124  DKTVKVWATHR--QKFLFSLSQHIN----------------------------------- 146

Query: 920  QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 979
             V C   SP  + I    ++  +++ +  +     S  +H   V ++ F      + ++ 
Sbjct: 147  WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG 206

Query: 980  DDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKD 1037
             D  ++VW+ +  + +   + H   V       +   L++ S D T+K+ +++ G     
Sbjct: 207  MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 266

Query: 1038 FVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1074
               HQG   +   S     F+S  +D+   +W  +FD++
Sbjct: 267  LHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 305



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 71/333 (21%), Positives = 130/333 (39%), Gaps = 47/333 (14%)

Query: 801  VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 859
            V C  +S +  ++   + +  + +W+   +S+     GH   V  V FSP G    + S 
Sbjct: 22   VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81

Query: 860  DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 919
            D+T+R+W            +K E   VF+ +   V +V                 + ++ 
Sbjct: 82   DKTVRIWVPN---------VKGE-STVFRAHTATVRSVH----------------FCSDG 115

Query: 920  QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 979
            Q           ++   D+   +++      +   S  QH   V   +F+ D + ++S+S
Sbjct: 116  Q----------SFVTASDDK-TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164

Query: 980  DDAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEK 1036
            DD  +++W+    +C+      G   T  DF     + + +   D TVKVW++ T    +
Sbjct: 165  DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQ 223

Query: 1037 DFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDS 1096
             +  H   V             + S+D T KI        L+ L GH G     AFS   
Sbjct: 224  HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283

Query: 1097 TLLATGDDNGEIRIWN-----VSNGELLHLCAP 1124
               A+G  + ++ +W      V +GE+  +  P
Sbjct: 284  EYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRP 316



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%)

Query: 921  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 979
            V+C   SP    +A G  +  + I  + N +   + F+ H  TV  + F +D ++ +++S
Sbjct: 64   VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122

Query: 980  DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1037
            DD  ++VW     K +F L  H   V+  +   + RL+ S S D TVK+W+  +      
Sbjct: 123  DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182

Query: 1038 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1097
            +  H G V   D     T  ++   D T K+W       L   + H+  V   +F     
Sbjct: 183  YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242

Query: 1098 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1153
             L T   +  ++I ++  G LL+            H G  T + FS  G+   S G
Sbjct: 243  YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 290



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 40/176 (22%), Positives = 67/176 (38%), Gaps = 36/176 (20%)

Query: 1035 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1094
            E+ F  H+  V   D S +  + +S S D    +W        +   GH   V C  FS 
Sbjct: 12   ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71

Query: 1095 DSTLLATGDDNGEIRIW-------------NVSNGELLHLCA------PLSEE------- 1128
               LLA+G  +  +RIW             + +    +H C+        S++       
Sbjct: 72   SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131

Query: 1129 --------GAATHGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNG 1174
                      + H  WV    FSPDG++++SA     +K W+  + E   ++  +G
Sbjct: 132  THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187


>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
           sapiens]
          Length = 472

 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 13/198 (6%)

Query: 587 EVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAET 646
           +VD+G+  ++    +NIT +S ++   HT ++   CF  D QR+AS   D+ ++++   +
Sbjct: 206 DVDHGICIMD---AENITTVS-VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261

Query: 647 GEKLLEI-KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL------VHTYDEHS 699
              LL I KAH + +  C F+    F+ T S DK +KIWN  TGE       V     H 
Sbjct: 262 QATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHE 321

Query: 700 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 759
             V+ CHF   S  L+  +G  D  + +WD+ +   + ++ GH + V     S + K + 
Sbjct: 322 GSVSSCHFARDSSFLI--SGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379

Query: 760 SCSADGTLKLWDATSANE 777
           S S D T++LW+    +E
Sbjct: 380 SASKDRTMRLWNIEEIDE 397



 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 75/342 (21%), Positives = 148/342 (43%), Gaps = 58/342 (16%)

Query: 741  GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 800
            GH ++V+ C F  DD  L S S D T+KLWD    +             + D +   +  
Sbjct: 100  GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSV------------VRDFEHRPKAP 147

Query: 801  VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 859
            V  CS + D +R++ A+ +K +  W+ ++   +   R + +++    FSPDG   ++  D
Sbjct: 148  VVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFD 206

Query: 860  DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 919
                                         ++ + ++  ++I  + +I       D+ T +
Sbjct: 207  ----------------------------VDHGICIMDAENITTVSVIK------DHHTRS 232

Query: 920  QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISS 978
             ++ CC  P  Q +A    +  I+I ++ +     +  + H   + +  FT     L +S
Sbjct: 233  -ITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS 291

Query: 979  SDDAEIQVWNWQLDK------CIFL-RGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNII 1030
            S D  +++WN    +      C+ L +GH+ +V      ++S  L+S  FD TV +W++ 
Sbjct: 292  SWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVA 351

Query: 1031 TGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1072
             G ++     H   V+   IS++     S S D+T ++W+ +
Sbjct: 352  EGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 59/258 (22%), Positives = 120/258 (46%), Gaps = 14/258 (5%)

Query: 618 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIAT-CS 676
           V     + D  R+ +   DKT++ +  ETG+ L +++ ++  ++ C FS D +++ +   
Sbjct: 148 VVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFD 206

Query: 677 VDKKVKIWNSMTGELVHTY-DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKEC 735
           VD  + I ++     V    D H+  +  C F   S  +  A+ S D  +K+WD+  +  
Sbjct: 207 VDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRV--ASVSLDRCIKIWDVTSQAT 264

Query: 736 RNTMF-GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQ 794
             T+   H+N++++C F+     L + S D  LK+W+  +   R                
Sbjct: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLM------- 317

Query: 795 EDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 853
           +  E  V  C ++ D + ++    ++ + +W+     +    +GH  WV  V  S +   
Sbjct: 318 QGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKW 377

Query: 854 FLTSSDDQTIRLWETKKV 871
            L++S D+T+RLW  +++
Sbjct: 378 ILSASKDRTMRLWNIEEI 395



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 66/324 (20%), Positives = 135/324 (41%), Gaps = 25/324 (7%)

Query: 595 LEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654
           L W ++  ++ +   ++  H  AV    F  D  ++ S   D T++++    G  + + +
Sbjct: 82  LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141

Query: 655 AH-EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 713
              +  V+ C+ + D   +   S DK V+ W+  TG+L+     +   +  C F+    +
Sbjct: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKY 200

Query: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
           ++           +   N          HT S+  C F PD + +AS S D  +K+WD T
Sbjct: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260

Query: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKV 832
           S     +I            +     I  CC ++  G  +  ++ +K + +WN  +  + 
Sbjct: 261 SQATLLTIT-----------KAHSNAISNCC-FTFSGHFLCTSSWDKNLKIWNVHT-GEF 307

Query: 833 ADC-------RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQE--V 883
            +C       +GH   V    F+ D S  ++   D+T+ +W+  +  +  ++    +  +
Sbjct: 308 RNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVM 367

Query: 884 DVVFQENEVMVLAVDHIRRLQLIN 907
           DV    N+  +L+    R ++L N
Sbjct: 368 DVAISNNKKWILSASKDRTMRLWN 391



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 13/172 (7%)

Query: 997  LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCH-QGTVLSCDISHDA 1054
            L GH+  V      + +++LLS S+D TVK+W+ + G+  +DF    +  V+ C I+ D+
Sbjct: 98   LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157

Query: 1055 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG-DDNGEIRIWNV 1113
            ++  + S DKT + W  +    L ++R     V C  FS D   + +G D +  I I + 
Sbjct: 158  SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK-FSPDGKYVVSGFDVDHGICIMDA 216

Query: 1114 SNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML--ISAGGYIKWWNVVT 1163
             N   + +           H   +T  CF PD + +  +S    IK W+V +
Sbjct: 217  ENITTVSVIKD-------HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 56/337 (16%)

Query: 837  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEV-DVVFQENEVM 893
            GH   V    F  D +  L+ S D T++LW+     V ++     K  V +     +   
Sbjct: 100  GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159

Query: 894  VLAVDHIRRLQLINGRTGQIDYLT--EAQVSCCCLSPHLQYIAFG-DENGAIEILELVN- 949
            V+A  + + ++  +  TG++ +    +  +  C  SP  +Y+  G D +  I I++  N 
Sbjct: 160  VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENI 219

Query: 950  NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNW--QLDKCIFLRGHQETVKDF 1007
              +   +  H +++    F  D + + S S D  I++W+   Q       + H   + + 
Sbjct: 220  TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNC 279

Query: 1008 RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1066
                +   L + S+D  +K+WN+ TG                       +F +  A  T 
Sbjct: 280  CFTFSGHFLCTSSWDKNLKIWNVHTG-----------------------EFRNCGACVTL 316

Query: 1067 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1126
                         ++GH G V    F+ DS+ L +G  +  + IW+V+ G        LS
Sbjct: 317  -------------MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG-----YRKLS 358

Query: 1127 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1161
             +G   H  WV D+  S + K ++SA     ++ WN+
Sbjct: 359  LKG---HNDWVMDVAISNNKKWILSASKDRTMRLWNI 392


>gi|148727341 serine/threonine kinase receptor associated protein
           [Homo sapiens]
          Length = 350

 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 75/286 (26%), Positives = 126/286 (44%), Gaps = 35/286 (12%)

Query: 614 HTDAVYHACFS---EDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
           HT  V    FS     G  + S   D    + + +TG+ +     H+  V     + D  
Sbjct: 13  HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72

Query: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 730
             AT + D   K+W++++G+ + T   H   V    FT  S++LL  TG  D  L+++DL
Sbjct: 73  KAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLL--TGGQDKLLRIYDL 129

Query: 731 NQKECR-NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789
           N+ E     + GHT+ +    +  +DK + S   D T++LWD  +  E KS+N      +
Sbjct: 130 NKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSLNFNMSVSS 188

Query: 790 LE------------------------DPQEDMEVIVKCCSWSADGARIMVAAKN---KIF 822
           +E                        DP +  E      S S    +  + A     K++
Sbjct: 189 MEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDFKLY 248

Query: 823 LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 868
            ++ +S  ++   +GH   +H V FSPDG  + + S+D T+RLW+T
Sbjct: 249 KYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQT 294



 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 50/260 (19%), Positives = 109/260 (41%), Gaps = 19/260 (7%)

Query: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797
           T  GH  +V     + D    A+ +AD T K+WDA S +E  ++  K             
Sbjct: 54  TFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKH------------ 101

Query: 798 EVIVKCCSWSADGARIMVAAKNKIF-LWNTDS-RSKVADCRGHLSWVHGVMFSPDGSSFL 855
             IVK   ++ D   ++   ++K+  +++ +   ++  +  GH S +   ++  +    L
Sbjct: 102 --IVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQIL 159

Query: 856 TSSDDQTIRLWETKKVCKNSAVMLKQEVDVV--FQENEVMVLAVDHIRRLQLINGRTGQI 913
            S+DD+T+RLW+   + +  ++     V  +    E E++V+                  
Sbjct: 160 -SADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIK 218

Query: 914 DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 973
            +   A ++   L P  +++  G E+  +   +  +    +S   H   +  ++F+ D +
Sbjct: 219 SFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGE 278

Query: 974 TLISSSDDAEIQVWNWQLDK 993
              S S+D  +++W   + K
Sbjct: 279 LYASGSEDGTLRLWQTVVGK 298



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 35/106 (33%), Positives = 55/106 (51%), Gaps = 7/106 (6%)

Query: 1015 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW---SF 1071
            L+S   DG   +    TG+    F+ H+G V    ++ DATK ++ +AD TAK+W   S 
Sbjct: 32   LISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSG 91

Query: 1072 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1117
            D L+ L     H   V+   F+ DS  L TG  +  +RI++++  E
Sbjct: 92   DELMTL----AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPE 133



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 55/310 (17%), Positives = 109/310 (35%), Gaps = 49/310 (15%)

Query: 813  IMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVC 872
            I      K  L   D+   +    GH   V G   + D +   T++ D T ++W+     
Sbjct: 33   ISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDA---- 88

Query: 873  KNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQY 932
                             +E+M LA  HI +          +D+  ++            Y
Sbjct: 89   --------------VSGDELMTLAHKHIVKT---------VDFTQDSN-----------Y 114

Query: 933  IAFGDENGAIEILELVNNRIFQSRFQH-----KKTVWHIQFTADEKTLISSSDDAEIQVW 987
            +  G ++  + I +L                 KK +W       E   I S+DD  +++W
Sbjct: 115  LLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALW-----CSEDKQILSADDKTVRLW 169

Query: 988  NWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLS 1047
            +      +       +V     +    +L  ++  ++   + ++ +  K F     T+ S
Sbjct: 170  DHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEA-PATINS 228

Query: 1048 CDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGE 1107
              +  +     +   D     + ++    L   +GH G + C  FS D  L A+G ++G 
Sbjct: 229  ASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGT 288

Query: 1108 IRIWNVSNGE 1117
            +R+W    G+
Sbjct: 289  LRLWQTVVGK 298



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 17/57 (29%), Positives = 28/57 (49%)

Query: 634 GADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGE 690
           G D  L  +   +GE+L   K H   + C  FS D    A+ S D  +++W ++ G+
Sbjct: 242 GEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298



 Score = 35.0 bits (79), Expect = 0.43
 Identities = 43/249 (17%), Positives = 91/249 (36%), Gaps = 14/249 (5%)

Query: 959  HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLS 1017
            HK  VW      D     +++ D   +VW+      +    H+  VK     ++S  LL+
Sbjct: 58   HKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLT 117

Query: 1018 WSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL 1077
               D  ++++++     E   +    + +   +     K   ++ DKT ++W    +  +
Sbjct: 118  GGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEV 177

Query: 1078 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1137
              L         S  S++          GEI +         H    L    +      +
Sbjct: 178  KSLN-----FNMSVSSMEYI------PEGEILVITYGRSIAFHSAVSLDPIKSFEAPATI 226

Query: 1138 TDLCFSPDGKMLISAGGYIKW--WNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNL 1195
                  P+ + L++ G   K   ++  +GE  +++  +   +  +  SPD + Y +    
Sbjct: 227  NSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED 286

Query: 1196 GILYILQTL 1204
            G L + QT+
Sbjct: 287  GTLRLWQTV 295


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 67/261 (25%), Positives = 118/261 (45%), Gaps = 27/261 (10%)

Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
           V++ H D V   C    G RI S   D TL+V+ A TG+ L  +  H   V        D
Sbjct: 257 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 313

Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
             I + S D+ +K+WN+ TGE +HT   H+  V C H     H   + +GS D  L++WD
Sbjct: 314 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 369

Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789
           +   +C + + GH  +V   ++  D + + S + D  +K+WD  +      ++  Q   N
Sbjct: 370 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 424

Query: 790 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFS 848
                       +  S   DG  ++  +    I +W+ ++ + +    GH S   G+   
Sbjct: 425 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 472

Query: 849 PDGSSFLTSSDDQTIRLWETK 869
              +  ++ + D T+++W+ K
Sbjct: 473 --DNILVSGNADSTVKIWDIK 491



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%)

Query: 851  GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 908
            G+  ++ SDD T+++W   T K  +              ++N ++  + D  R L++ N 
Sbjct: 273  GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 330

Query: 909  RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 967
             TG+  +      S   C+  H + +  G  +  + + ++   +       H   V  +Q
Sbjct: 331  ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 390

Query: 968  FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1026
            +  D + ++S + D  ++VW+ + + C+  L+GH   V   +      ++S S D +++V
Sbjct: 391  Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 447

Query: 1027 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1083
            W++ TGN       HQ      ++  +     S +AD T KIW       L  L+G   H
Sbjct: 448  WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 505

Query: 1084 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1130
               V C  F+     + T  D+G +++W++  GE +     L   G+
Sbjct: 506  QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 550



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%)

Query: 933  IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 992
            I  G ++  +++   V  +  ++   H   VW  Q    +  +IS S D  ++VWN +  
Sbjct: 276  IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 333

Query: 993  KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1051
            +CI  L GH  TV+   L    R++S S D T++VW+I TG      + H   V    + 
Sbjct: 334  ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 390

Query: 1052 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1111
            +D  +  S + D   K+W  +    LH L+GH    R  +   D   + +G  +  IR+W
Sbjct: 391  YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 448

Query: 1112 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1136
            +V  G  +H                                          +G   H   
Sbjct: 449  DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 508

Query: 1137 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1172
            VT L F+ +  +  S  G +K W++ TGE  +   T
Sbjct: 509  VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 544



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 46/165 (27%), Positives = 83/165 (50%), Gaps = 13/165 (7%)

Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
           V+  H  AV   C   DG+R+ S   D  ++V+  ET   L  ++ H + V    F  D 
Sbjct: 378 VLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DG 433

Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
             + + S+D  +++W+  TG  +HT   H    +     ++    +L +G++D  +K+WD
Sbjct: 434 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN----ILVSGNADSTVKIWD 489

Query: 730 LNQKECRNTMFG---HTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
           +   +C  T+ G   H ++V   +F+ +   + + S DGT+KLWD
Sbjct: 490 IKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWD 532



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%)

Query: 988  NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
            NW   +L     L+GH + V        +R++S S D T+KVW+ +TG   +  V H G 
Sbjct: 246  NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 305

Query: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1104
            V S  +  +     S S D+T K+W+ +    +H L GH   VRC    +    + +G  
Sbjct: 306  VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 361

Query: 1105 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1161
            +  +R+W++  G+ LH+   L    AA         C   DG+ ++S G Y   +K W+ 
Sbjct: 362  DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 410

Query: 1162 VT 1163
             T
Sbjct: 411  ET 412



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 11/124 (8%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           HT+ VY   F  DG  + S   D +++V+  ETG  +  +  H+   L       D  + 
Sbjct: 422 HTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILV 477

Query: 674 TCSVDKKVKIWNSMTGELVHTY---DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 730
           + + D  VKIW+  TG+ + T    ++H   V C  F  +     + T S D  +KLWDL
Sbjct: 478 SGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDDGTVKLWDL 533

Query: 731 NQKE 734
              E
Sbjct: 534 KTGE 537



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%)

Query: 630 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 686
           + S  AD T++++  +TG+ L  ++    H+  V C  F+ +  F+ T S D  VK+W+ 
Sbjct: 476 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 533

Query: 687 MTGELV 692
            TGE +
Sbjct: 534 KTGEFI 539



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%)

Query: 1080 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1138
            L+GH+   + C  F      + +G D+  +++W+   G+ L            T G W +
Sbjct: 258  LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 309

Query: 1139 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1182
             +       ++IS      +K WN  TGE   T Y + + ++ +H+
Sbjct: 310  QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 351


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 67/261 (25%), Positives = 118/261 (45%), Gaps = 27/261 (10%)

Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
           V++ H D V   C    G RI S   D TL+V+ A TG+ L  +  H   V        D
Sbjct: 375 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 431

Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
             I + S D+ +K+WN+ TGE +HT   H+  V C H     H   + +GS D  L++WD
Sbjct: 432 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 487

Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789
           +   +C + + GH  +V   ++  D + + S + D  +K+WD  +      ++  Q   N
Sbjct: 488 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 542

Query: 790 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFS 848
                       +  S   DG  ++  +    I +W+ ++ + +    GH S   G+   
Sbjct: 543 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 590

Query: 849 PDGSSFLTSSDDQTIRLWETK 869
              +  ++ + D T+++W+ K
Sbjct: 591 --DNILVSGNADSTVKIWDIK 609



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%)

Query: 851  GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 908
            G+  ++ SDD T+++W   T K  +              ++N ++  + D  R L++ N 
Sbjct: 391  GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 448

Query: 909  RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 967
             TG+  +      S   C+  H + +  G  +  + + ++   +       H   V  +Q
Sbjct: 449  ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 508

Query: 968  FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1026
            +  D + ++S + D  ++VW+ + + C+  L+GH   V   +      ++S S D +++V
Sbjct: 509  Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 565

Query: 1027 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1083
            W++ TGN       HQ      ++  +     S +AD T KIW       L  L+G   H
Sbjct: 566  WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 623

Query: 1084 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1130
               V C  F+     + T  D+G +++W++  GE +     L   G+
Sbjct: 624  QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 668



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%)

Query: 933  IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 992
            I  G ++  +++   V  +  ++   H   VW  Q    +  +IS S D  ++VWN +  
Sbjct: 394  IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 451

Query: 993  KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1051
            +CI  L GH  TV+   L    R++S S D T++VW+I TG      + H   V    + 
Sbjct: 452  ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 508

Query: 1052 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1111
            +D  +  S + D   K+W  +    LH L+GH    R  +   D   + +G  +  IR+W
Sbjct: 509  YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 566

Query: 1112 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1136
            +V  G  +H                                          +G   H   
Sbjct: 567  DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 626

Query: 1137 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1172
            VT L F+ +  +  S  G +K W++ TGE  +   T
Sbjct: 627  VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 662



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 46/165 (27%), Positives = 83/165 (50%), Gaps = 13/165 (7%)

Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
           V+  H  AV   C   DG+R+ S   D  ++V+  ET   L  ++ H + V    F  D 
Sbjct: 496 VLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DG 551

Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
             + + S+D  +++W+  TG  +HT   H    +     ++    +L +G++D  +K+WD
Sbjct: 552 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN----ILVSGNADSTVKIWD 607

Query: 730 LNQKECRNTMFG---HTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
           +   +C  T+ G   H ++V   +F+ +   + + S DGT+KLWD
Sbjct: 608 IKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWD 650



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%)

Query: 988  NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
            NW   +L     L+GH + V        +R++S S D T+KVW+ +TG   +  V H G 
Sbjct: 364  NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 423

Query: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1104
            V S  +  +     S S D+T K+W+ +    +H L GH   VRC    +    + +G  
Sbjct: 424  VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 479

Query: 1105 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1161
            +  +R+W++  G+ LH+   L    AA         C   DG+ ++S G Y   +K W+ 
Sbjct: 480  DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 528

Query: 1162 VT 1163
             T
Sbjct: 529  ET 530



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 11/124 (8%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           HT+ VY   F  DG  + S   D +++V+  ETG  +  +  H+   L       D  + 
Sbjct: 540 HTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILV 595

Query: 674 TCSVDKKVKIWNSMTGELVHTY---DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 730
           + + D  VKIW+  TG+ + T    ++H   V C  F  +     + T S D  +KLWDL
Sbjct: 596 SGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDDGTVKLWDL 651

Query: 731 NQKE 734
              E
Sbjct: 652 KTGE 655



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%)

Query: 630 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 686
           + S  AD T++++  +TG+ L  ++    H+  V C  F+ +  F+ T S D  VK+W+ 
Sbjct: 594 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 651

Query: 687 MTGELV 692
            TGE +
Sbjct: 652 KTGEFI 657



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%)

Query: 1080 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1138
            L+GH+   + C  F      + +G D+  +++W+   G+ L            T G W +
Sbjct: 376  LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 427

Query: 1139 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1182
             +       ++IS      +K WN  TGE   T Y + + ++ +H+
Sbjct: 428  QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 469


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 67/261 (25%), Positives = 118/261 (45%), Gaps = 27/261 (10%)

Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
           V++ H D V   C    G RI S   D TL+V+ A TG+ L  +  H   V        D
Sbjct: 295 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 351

Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
             I + S D+ +K+WN+ TGE +HT   H+  V C H     H   + +GS D  L++WD
Sbjct: 352 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 407

Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789
           +   +C + + GH  +V   ++  D + + S + D  +K+WD  +      ++  Q   N
Sbjct: 408 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 462

Query: 790 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFS 848
                       +  S   DG  ++  +    I +W+ ++ + +    GH S   G+   
Sbjct: 463 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 510

Query: 849 PDGSSFLTSSDDQTIRLWETK 869
              +  ++ + D T+++W+ K
Sbjct: 511 --DNILVSGNADSTVKIWDIK 529



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%)

Query: 851  GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 908
            G+  ++ SDD T+++W   T K  +              ++N ++  + D  R L++ N 
Sbjct: 311  GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 368

Query: 909  RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 967
             TG+  +      S   C+  H + +  G  +  + + ++   +       H   V  +Q
Sbjct: 369  ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 428

Query: 968  FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1026
            +  D + ++S + D  ++VW+ + + C+  L+GH   V   +      ++S S D +++V
Sbjct: 429  Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 485

Query: 1027 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1083
            W++ TGN       HQ      ++  +     S +AD T KIW       L  L+G   H
Sbjct: 486  WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 543

Query: 1084 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1130
               V C  F+     + T  D+G +++W++  GE +     L   G+
Sbjct: 544  QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 588



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%)

Query: 933  IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 992
            I  G ++  +++   V  +  ++   H   VW  Q    +  +IS S D  ++VWN +  
Sbjct: 314  IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 371

Query: 993  KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1051
            +CI  L GH  TV+   L    R++S S D T++VW+I TG      + H   V    + 
Sbjct: 372  ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 428

Query: 1052 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1111
            +D  +  S + D   K+W  +    LH L+GH    R  +   D   + +G  +  IR+W
Sbjct: 429  YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 486

Query: 1112 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1136
            +V  G  +H                                          +G   H   
Sbjct: 487  DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 546

Query: 1137 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1172
            VT L F+ +  +  S  G +K W++ TGE  +   T
Sbjct: 547  VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 582



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 46/165 (27%), Positives = 83/165 (50%), Gaps = 13/165 (7%)

Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
           V+  H  AV   C   DG+R+ S   D  ++V+  ET   L  ++ H + V    F  D 
Sbjct: 416 VLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DG 471

Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
             + + S+D  +++W+  TG  +HT   H    +     ++    +L +G++D  +K+WD
Sbjct: 472 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN----ILVSGNADSTVKIWD 527

Query: 730 LNQKECRNTMFG---HTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
           +   +C  T+ G   H ++V   +F+ +   + + S DGT+KLWD
Sbjct: 528 IKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWD 570



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%)

Query: 988  NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
            NW   +L     L+GH + V        +R++S S D T+KVW+ +TG   +  V H G 
Sbjct: 284  NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 343

Query: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1104
            V S  +  +     S S D+T K+W+ +    +H L GH   VRC    +    + +G  
Sbjct: 344  VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 399

Query: 1105 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1161
            +  +R+W++  G+ LH+   L    AA         C   DG+ ++S G Y   +K W+ 
Sbjct: 400  DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 448

Query: 1162 VT 1163
             T
Sbjct: 449  ET 450



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 11/124 (8%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           HT+ VY   F  DG  + S   D +++V+  ETG  +  +  H+   L       D  + 
Sbjct: 460 HTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILV 515

Query: 674 TCSVDKKVKIWNSMTGELVHTY---DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 730
           + + D  VKIW+  TG+ + T    ++H   V C  F  +     + T S D  +KLWDL
Sbjct: 516 SGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDDGTVKLWDL 571

Query: 731 NQKE 734
              E
Sbjct: 572 KTGE 575



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%)

Query: 630 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 686
           + S  AD T++++  +TG+ L  ++    H+  V C  F+ +  F+ T S D  VK+W+ 
Sbjct: 514 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 571

Query: 687 MTGELV 692
            TGE +
Sbjct: 572 KTGEFI 577



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%)

Query: 1080 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1138
            L+GH+   + C  F      + +G D+  +++W+   G+ L            T G W +
Sbjct: 296  LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 347

Query: 1139 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1182
             +       ++IS      +K WN  TGE   T Y + + ++ +H+
Sbjct: 348  QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 389


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%)

Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
           V R HT  V    F  DGQ   +   DKT++V+     + L  +  H + V C  FS D 
Sbjct: 60  VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119

Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
           R I + S DK VK+W+  + E VH+Y EH   V    F  S     +A    D  +K+WD
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 177

Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
           +           H+ +VN   F P    L + S+D TLK+ D
Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 219



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 63/229 (27%), Positives = 100/229 (43%), Gaps = 12/229 (5%)

Query: 981  DAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDF 1038
            D+ + VW+ +     +   GH++ V       +  LL S S D TV++W      +   F
Sbjct: 2    DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 1039 VCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTL 1098
              H  TV S     D   F + S DKT K+W+      L  L  H   VRC+ FS D  L
Sbjct: 62   RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 1099 LATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYI 1156
            + +  D+  +++W+ S+ E +H            HGG+VT + F P G  + +AG    +
Sbjct: 122  IVSASDDKTVKLWDKSSRECVH--------SYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 173

Query: 1157 KWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1205
            K W+V T    Q +  +   +  +   P     +T  +   L IL  +E
Sbjct: 174  KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 222



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 66/264 (25%), Positives = 110/264 (41%), Gaps = 32/264 (12%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H DAV    FS  G  +AS   DKT++++      +    +AH   V    F +D +   
Sbjct: 22  HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           T S DK VK+W +   + + +  +H   V C  F+      L+ + S D  +KLWD + +
Sbjct: 82  TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSR 139

Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793
           EC ++   H   V +  F P    +A+   D T+K+WD      R    ++ + L+    
Sbjct: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV-----RTHRLLQHYQLH---- 190

Query: 794 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVAD---------CRGHLSWVHG 844
                  V   S+   G  ++ A        ++DS  K+ D           GH      
Sbjct: 191 ----SAAVNGLSFHPSGNYLITA--------SSDSTLKILDLMEGRLLYTLHGHQGPATT 238

Query: 845 VMFSPDGSSFLTSSDDQTIRLWET 868
           V FS  G  F +   D+ + +W++
Sbjct: 239 VAFSRTGEYFASGGSDEQVMVWKS 262



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 62/232 (26%), Positives = 105/232 (45%), Gaps = 18/232 (7%)

Query: 636 DKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIW-NSMTGELVHT 694
           D  L V+  +   +      H+D V C  FS     +A+ S DK V+IW  ++ GE    
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST-V 60

Query: 695 YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPD 754
           +  H+  V   HF +     +  T S D  +K+W  ++++   ++  H N V   +FSPD
Sbjct: 61  FRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118

Query: 755 DKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIM 814
            +L+ S S D T+KLWD +S     S      F+   D             +   G  I 
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD-------------FHPSGTCIA 165

Query: 815 VAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 865
            A   N + +W+  +   +   + H + V+G+ F P G+  +T+S D T+++
Sbjct: 166 AAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 69/317 (21%), Positives = 122/317 (38%), Gaps = 53/317 (16%)

Query: 677 VDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECR 736
           +D  + +W+       + +  H + V C +F+ S H  LLA+GS D  +++W  N K   
Sbjct: 1   MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH--LLASGSRDKTVRIWVPNVKGES 58

Query: 737 NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQED 796
                HT +V    F  D +   + S D T+K+W         + + ++F  +L      
Sbjct: 59  TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW---------ATHRQKFLFSLSQHIN- 108

Query: 797 MEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFL 855
               V+C  +S DG  I+ A+ +K + LW+  SR  V     H  +V  V F P G+   
Sbjct: 109 ---WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIA 165

Query: 856 TSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 915
            +  D T+++W+ +                                       R  Q   
Sbjct: 166 AAGMDNTVKVWDVR-------------------------------------THRLLQHYQ 188

Query: 916 LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 975
           L  A V+     P   Y+     +  ++IL+L+  R+  +   H+     + F+   +  
Sbjct: 189 LHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYF 248

Query: 976 ISSSDDAEIQVWNWQLD 992
            S   D ++ VW    D
Sbjct: 249 ASGGSDEQVMVWKSNFD 265



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%)

Query: 921  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 979
            V+C   SP    +A G  +  + I  + N +   + F+ H  TV  + F +D ++ +++S
Sbjct: 26   VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 84

Query: 980  DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1037
            DD  ++VW     K +F L  H   V+  +   + RL+ S S D TVK+W+  +      
Sbjct: 85   DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 144

Query: 1038 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1097
            +  H G V   D     T  ++   D T K+W       L   + H+  V   +F     
Sbjct: 145  YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 204

Query: 1098 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1153
             L T   +  ++I ++  G LL+            H G  T + FS  G+   S G
Sbjct: 205  YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 252



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 68/312 (21%), Positives = 121/312 (38%), Gaps = 46/312 (14%)

Query: 821  IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLK 880
            + +W+   +S+     GH   V  V FSP G    + S D+T+R+W            +K
Sbjct: 5    LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN---------VK 55

Query: 881  QEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENG 940
             E   VF+ +   V +V                 + ++ Q           ++   D+  
Sbjct: 56   GE-STVFRAHTATVRSVH----------------FCSDGQ----------SFVTASDDK- 87

Query: 941  AIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFL--- 997
             +++      +   S  QH   V   +F+ D + ++S+SDD  +++W+    +C+     
Sbjct: 88   TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE 147

Query: 998  RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKF 1057
             G   T  DF     + + +   D TVKVW++ T    + +  H   V            
Sbjct: 148  HGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYL 206

Query: 1058 SSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN----- 1112
             + S+D T KI        L+ L GH G     AFS      A+G  + ++ +W      
Sbjct: 207  ITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDI 266

Query: 1113 VSNGELLHLCAP 1124
            V +GE+  +  P
Sbjct: 267  VDHGEVTKVPRP 278



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 54/279 (19%), Positives = 113/279 (40%), Gaps = 42/279 (15%)

Query: 801  VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 859
            V C ++S  G  +   +++K + +W  + + +    R H + V  V F  DG SF+T+SD
Sbjct: 26   VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 85

Query: 860  DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 919
            D+T+++W T +  +     L Q ++                                   
Sbjct: 86   DKTVKVWATHR--QKFLFSLSQHIN----------------------------------- 108

Query: 920  QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 979
             V C   SP  + I    ++  +++ +  +     S  +H   V ++ F      + ++ 
Sbjct: 109  WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG 168

Query: 980  DDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKD 1037
             D  ++VW+ +  + +   + H   V       +   L++ S D T+K+ +++ G     
Sbjct: 169  MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 228

Query: 1038 FVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1074
               HQG   +   S     F+S  +D+   +W  +FD++
Sbjct: 229  LHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 267


>gi|189571685 WD repeat, sterile alpha motif and U-box domain
            containing 1 [Homo sapiens]
          Length = 476

 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 90/354 (25%), Positives = 144/354 (40%), Gaps = 64/354 (18%)

Query: 690  ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 747
            +L+HT  +H + VNCC F+ S    LLAT S D  ++L+ L    +   + +  HT +V+
Sbjct: 3    KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58

Query: 748  HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 807
             C FSP   +LASCS DGT  LW+  +          Q    +E P       V+ C +S
Sbjct: 59   CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106

Query: 808  ADGARIMV-AAKNKIFLWNTDSRSKVADC----RGHLSWVHGVMFSPDGSSFLTSSDDQT 862
             D   +   AA   + LWN  S  K+  C     G L+      FSP+GS F+T S    
Sbjct: 107  PDSTCLASGAADGTVVLWNAQS-YKLYRCGSVKDGSLA---ACAFSPNGSFFVTGSSCGD 162

Query: 863  IRLWETKKVCKNS----------AVMLKQEVDVVFQ--------------ENEVMVLAVD 898
            + +W+ K  C +S               Q V    Q              + ++ +++  
Sbjct: 163  LTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFT 222

Query: 899  HIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIF 953
            HI   +L     ++G          A V  C  S   Q +  G  + ++ + +     I 
Sbjct: 223  HILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENIL 274

Query: 954  QSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 1007
             +  QH + V    F  +   L + S D  + +W + L+     R  +  +K F
Sbjct: 275  HTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQF 328



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 69/279 (24%), Positives = 122/279 (43%), Gaps = 21/279 (7%)

Query: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 659
           ++ T L    ++ HT AV+  CFS  G  +ASC  D T  ++  E G+ L  ++      
Sbjct: 40  RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99

Query: 660 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 719
           V  C FS D   +A+ + D  V +WN+ + +L          +  C F  S +     TG
Sbjct: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157

Query: 720 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 769
           SS   L +WD ++  C ++   H   +  C FS               LASC  D  +K+
Sbjct: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216

Query: 770 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDS 828
           W  +        ++  F L  +         V  C++S DG  ++  + +K + +++T++
Sbjct: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270

Query: 829 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867
            + +     H  +V    F+P+     T S D+T+ +W+
Sbjct: 271 ENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ 309



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 9/110 (8%)

Query: 629 RIASCGADKTLQVFKAETGEKL-LEIK------AHEDEVLCCAFSTDDRFIATCSVDKKV 681
           R+ASCG D  ++++       L  E+K       H   VL CAFS D + + + SVDK V
Sbjct: 204 RLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSV 263

Query: 682 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731
            ++++ T  ++HT  +H+  V  C F  ++  LLLATGS D  + +W  +
Sbjct: 264 IVYDTNTENILHTLTQHTRYVTTCAFAPNT--LLLATGSMDKTVNIWQFD 311



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 75/358 (20%), Positives = 130/358 (36%), Gaps = 72/358 (20%)

Query: 737  NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQED 796
            +T+  H + VN C FS    LLA+CS D T++L+           +++ F      P + 
Sbjct: 6    HTLADHGDDVNCCAFS--FSLLATCSLDKTIRLY-----------SLRDFTELPHSPLKF 52

Query: 797  MEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVADCRGHL-SWVHGVMFSPDGSSF 854
                V CC +S  G  +   + +    LWNT++   +A       S V    FSPD +  
Sbjct: 53   HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112

Query: 855  LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 914
             + + D T+ LW  +                                       +  +  
Sbjct: 113  ASGAADGTVVLWNAQSY-------------------------------------KLYRCG 135

Query: 915  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 974
             + +  ++ C  SP+  +   G   G + + +    R   S   H   +    F++   +
Sbjct: 136  SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194

Query: 975  ----------LISSSDDAEIQVW--------NWQLDKCIFLRGHQETVKDFRLLKNSRLL 1016
                      L S   D ++++W         ++L     L GH   V       + ++L
Sbjct: 195  DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254

Query: 1017 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1073
             S S D +V V++  T N       H   V +C  + +    ++ S DKT  IW FDL
Sbjct: 255  VSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDL 312



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 67/297 (22%), Positives = 110/297 (37%), Gaps = 64/297 (21%)

Query: 838  HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 897
            H   VH   FSP G    + S D T  LW T                    EN  M+  +
Sbjct: 53   HTYAVHCCCFSPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVM 92

Query: 898  DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 957
            +                  + + V  C  SP    +A G  +G + +    + ++++   
Sbjct: 93   EQP----------------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGS 136

Query: 958  QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL-------- 1009
                ++    F+ +    ++ S   ++ VW+ ++ +C+    H E   D  +        
Sbjct: 137  VKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQ 191

Query: 1010 --------LKNSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDA 1054
                    L+  RL S   D  VK+W +    I G + K       H   VL+C  SHD 
Sbjct: 192  PVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDG 251

Query: 1055 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1111
                S S DK+  ++  +    LH L  H   V   AF+ ++ LLATG  +  + IW
Sbjct: 252  QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)

Query: 921  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 979
            V CCC SP    +A    +G   +    N ++     Q   +   + QF+ D   L S +
Sbjct: 57   VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116

Query: 980  DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1031
             D  + +WN Q  K ++  G   +VKD  L         S  ++ S  G + VW+  +  
Sbjct: 117  ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172

Query: 1032 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1078
             + EK    H   +  CD S              + +S   D   KIW  SF  +L    
Sbjct: 173  LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229

Query: 1079 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1134
                 L GH   V   AFS D  +L +G  +  + +++ +   +LH            H 
Sbjct: 230  KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281

Query: 1135 GWVTDLCFSPDGKMLISAGGYIKWWNV 1161
             +VT   F+P+  +L++ G   K  N+
Sbjct: 282  RYVTTCAFAPN-TLLLATGSMDKTVNI 307



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)

Query: 1049 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1103
            D++  A  FS   + S DKT +++S      LP   L+ H   V C  FS    +LA+  
Sbjct: 14   DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73

Query: 1104 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1161
             +G   +WN  NG++L +    S       G  V    FSPD   L S  A G +  WN 
Sbjct: 74   TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126

Query: 1162 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1200
             + +  +       +L     SP+   +VT  + G L +
Sbjct: 127  QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165



 Score = 38.1 bits (87), Expect = 0.051
 Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)

Query: 1077 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1135
            +H L  H   V C AFS   +LLAT   +  IR++++ +  EL H  +PL     A H  
Sbjct: 5    IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58

Query: 1136 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1185
                 CFSP G +L S    G    WN   G+        +G+ ++    SPD
Sbjct: 59   ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108


>gi|189571683 WD repeat, sterile alpha motif and U-box domain
            containing 1 [Homo sapiens]
          Length = 476

 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 90/354 (25%), Positives = 144/354 (40%), Gaps = 64/354 (18%)

Query: 690  ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 747
            +L+HT  +H + VNCC F+ S    LLAT S D  ++L+ L    +   + +  HT +V+
Sbjct: 3    KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58

Query: 748  HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 807
             C FSP   +LASCS DGT  LW+  +          Q    +E P       V+ C +S
Sbjct: 59   CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106

Query: 808  ADGARIMV-AAKNKIFLWNTDSRSKVADC----RGHLSWVHGVMFSPDGSSFLTSSDDQT 862
             D   +   AA   + LWN  S  K+  C     G L+      FSP+GS F+T S    
Sbjct: 107  PDSTCLASGAADGTVVLWNAQS-YKLYRCGSVKDGSLA---ACAFSPNGSFFVTGSSCGD 162

Query: 863  IRLWETKKVCKNS----------AVMLKQEVDVVFQ--------------ENEVMVLAVD 898
            + +W+ K  C +S               Q V    Q              + ++ +++  
Sbjct: 163  LTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFT 222

Query: 899  HIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIF 953
            HI   +L     ++G          A V  C  S   Q +  G  + ++ + +     I 
Sbjct: 223  HILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENIL 274

Query: 954  QSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 1007
             +  QH + V    F  +   L + S D  + +W + L+     R  +  +K F
Sbjct: 275  HTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQF 328



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 69/279 (24%), Positives = 122/279 (43%), Gaps = 21/279 (7%)

Query: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 659
           ++ T L    ++ HT AV+  CFS  G  +ASC  D T  ++  E G+ L  ++      
Sbjct: 40  RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99

Query: 660 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 719
           V  C FS D   +A+ + D  V +WN+ + +L          +  C F  S +     TG
Sbjct: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157

Query: 720 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 769
           SS   L +WD ++  C ++   H   +  C FS               LASC  D  +K+
Sbjct: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216

Query: 770 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDS 828
           W  +        ++  F L  +         V  C++S DG  ++  + +K + +++T++
Sbjct: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270

Query: 829 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867
            + +     H  +V    F+P+     T S D+T+ +W+
Sbjct: 271 ENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ 309



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 9/110 (8%)

Query: 629 RIASCGADKTLQVFKAETGEKL-LEIK------AHEDEVLCCAFSTDDRFIATCSVDKKV 681
           R+ASCG D  ++++       L  E+K       H   VL CAFS D + + + SVDK V
Sbjct: 204 RLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSV 263

Query: 682 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731
            ++++ T  ++HT  +H+  V  C F  ++  LLLATGS D  + +W  +
Sbjct: 264 IVYDTNTENILHTLTQHTRYVTTCAFAPNT--LLLATGSMDKTVNIWQFD 311



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 75/358 (20%), Positives = 130/358 (36%), Gaps = 72/358 (20%)

Query: 737  NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQED 796
            +T+  H + VN C FS    LLA+CS D T++L+           +++ F      P + 
Sbjct: 6    HTLADHGDDVNCCAFS--FSLLATCSLDKTIRLY-----------SLRDFTELPHSPLKF 52

Query: 797  MEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVADCRGHL-SWVHGVMFSPDGSSF 854
                V CC +S  G  +   + +    LWNT++   +A       S V    FSPD +  
Sbjct: 53   HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112

Query: 855  LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 914
             + + D T+ LW  +                                       +  +  
Sbjct: 113  ASGAADGTVVLWNAQSY-------------------------------------KLYRCG 135

Query: 915  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 974
             + +  ++ C  SP+  +   G   G + + +    R   S   H   +    F++   +
Sbjct: 136  SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194

Query: 975  ----------LISSSDDAEIQVW--------NWQLDKCIFLRGHQETVKDFRLLKNSRLL 1016
                      L S   D ++++W         ++L     L GH   V       + ++L
Sbjct: 195  DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254

Query: 1017 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1073
             S S D +V V++  T N       H   V +C  + +    ++ S DKT  IW FDL
Sbjct: 255  VSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDL 312



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 67/297 (22%), Positives = 110/297 (37%), Gaps = 64/297 (21%)

Query: 838  HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 897
            H   VH   FSP G    + S D T  LW T                    EN  M+  +
Sbjct: 53   HTYAVHCCCFSPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVM 92

Query: 898  DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 957
            +                  + + V  C  SP    +A G  +G + +    + ++++   
Sbjct: 93   EQP----------------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGS 136

Query: 958  QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL-------- 1009
                ++    F+ +    ++ S   ++ VW+ ++ +C+    H E   D  +        
Sbjct: 137  VKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQ 191

Query: 1010 --------LKNSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDA 1054
                    L+  RL S   D  VK+W +    I G + K       H   VL+C  SHD 
Sbjct: 192  PVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDG 251

Query: 1055 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1111
                S S DK+  ++  +    LH L  H   V   AF+ ++ LLATG  +  + IW
Sbjct: 252  QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)

Query: 921  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 979
            V CCC SP    +A    +G   +    N ++     Q   +   + QF+ D   L S +
Sbjct: 57   VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116

Query: 980  DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1031
             D  + +WN Q  K ++  G   +VKD  L         S  ++ S  G + VW+  +  
Sbjct: 117  ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172

Query: 1032 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1078
             + EK    H   +  CD S              + +S   D   KIW  SF  +L    
Sbjct: 173  LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229

Query: 1079 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1134
                 L GH   V   AFS D  +L +G  +  + +++ +   +LH            H 
Sbjct: 230  KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281

Query: 1135 GWVTDLCFSPDGKMLISAGGYIKWWNV 1161
             +VT   F+P+  +L++ G   K  N+
Sbjct: 282  RYVTTCAFAPN-TLLLATGSMDKTVNI 307



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)

Query: 1049 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1103
            D++  A  FS   + S DKT +++S      LP   L+ H   V C  FS    +LA+  
Sbjct: 14   DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73

Query: 1104 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1161
             +G   +WN  NG++L +    S       G  V    FSPD   L S  A G +  WN 
Sbjct: 74   TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126

Query: 1162 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1200
             + +  +       +L     SP+   +VT  + G L +
Sbjct: 127  QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165



 Score = 38.1 bits (87), Expect = 0.051
 Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)

Query: 1077 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1135
            +H L  H   V C AFS   +LLAT   +  IR++++ +  EL H  +PL     A H  
Sbjct: 5    IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58

Query: 1136 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1185
                 CFSP G +L S    G    WN   G+        +G+ ++    SPD
Sbjct: 59   ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108


>gi|189571681 WD repeat, sterile alpha motif and U-box domain
            containing 1 [Homo sapiens]
          Length = 476

 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 90/354 (25%), Positives = 144/354 (40%), Gaps = 64/354 (18%)

Query: 690  ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 747
            +L+HT  +H + VNCC F+ S    LLAT S D  ++L+ L    +   + +  HT +V+
Sbjct: 3    KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58

Query: 748  HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 807
             C FSP   +LASCS DGT  LW+  +          Q    +E P       V+ C +S
Sbjct: 59   CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106

Query: 808  ADGARIMV-AAKNKIFLWNTDSRSKVADC----RGHLSWVHGVMFSPDGSSFLTSSDDQT 862
             D   +   AA   + LWN  S  K+  C     G L+      FSP+GS F+T S    
Sbjct: 107  PDSTCLASGAADGTVVLWNAQS-YKLYRCGSVKDGSLA---ACAFSPNGSFFVTGSSCGD 162

Query: 863  IRLWETKKVCKNS----------AVMLKQEVDVVFQ--------------ENEVMVLAVD 898
            + +W+ K  C +S               Q V    Q              + ++ +++  
Sbjct: 163  LTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFT 222

Query: 899  HIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIF 953
            HI   +L     ++G          A V  C  S   Q +  G  + ++ + +     I 
Sbjct: 223  HILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENIL 274

Query: 954  QSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 1007
             +  QH + V    F  +   L + S D  + +W + L+     R  +  +K F
Sbjct: 275  HTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQF 328



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 69/279 (24%), Positives = 122/279 (43%), Gaps = 21/279 (7%)

Query: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 659
           ++ T L    ++ HT AV+  CFS  G  +ASC  D T  ++  E G+ L  ++      
Sbjct: 40  RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99

Query: 660 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 719
           V  C FS D   +A+ + D  V +WN+ + +L          +  C F  S +     TG
Sbjct: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157

Query: 720 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 769
           SS   L +WD ++  C ++   H   +  C FS               LASC  D  +K+
Sbjct: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216

Query: 770 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDS 828
           W  +        ++  F L  +         V  C++S DG  ++  + +K + +++T++
Sbjct: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270

Query: 829 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867
            + +     H  +V    F+P+     T S D+T+ +W+
Sbjct: 271 ENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ 309



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 9/110 (8%)

Query: 629 RIASCGADKTLQVFKAETGEKL-LEIK------AHEDEVLCCAFSTDDRFIATCSVDKKV 681
           R+ASCG D  ++++       L  E+K       H   VL CAFS D + + + SVDK V
Sbjct: 204 RLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSV 263

Query: 682 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731
            ++++ T  ++HT  +H+  V  C F  ++  LLLATGS D  + +W  +
Sbjct: 264 IVYDTNTENILHTLTQHTRYVTTCAFAPNT--LLLATGSMDKTVNIWQFD 311



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 75/358 (20%), Positives = 130/358 (36%), Gaps = 72/358 (20%)

Query: 737  NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQED 796
            +T+  H + VN C FS    LLA+CS D T++L+           +++ F      P + 
Sbjct: 6    HTLADHGDDVNCCAFS--FSLLATCSLDKTIRLY-----------SLRDFTELPHSPLKF 52

Query: 797  MEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVADCRGHL-SWVHGVMFSPDGSSF 854
                V CC +S  G  +   + +    LWNT++   +A       S V    FSPD +  
Sbjct: 53   HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112

Query: 855  LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 914
             + + D T+ LW  +                                       +  +  
Sbjct: 113  ASGAADGTVVLWNAQSY-------------------------------------KLYRCG 135

Query: 915  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 974
             + +  ++ C  SP+  +   G   G + + +    R   S   H   +    F++   +
Sbjct: 136  SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194

Query: 975  ----------LISSSDDAEIQVW--------NWQLDKCIFLRGHQETVKDFRLLKNSRLL 1016
                      L S   D ++++W         ++L     L GH   V       + ++L
Sbjct: 195  DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254

Query: 1017 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1073
             S S D +V V++  T N       H   V +C  + +    ++ S DKT  IW FDL
Sbjct: 255  VSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDL 312



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 67/297 (22%), Positives = 110/297 (37%), Gaps = 64/297 (21%)

Query: 838  HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 897
            H   VH   FSP G    + S D T  LW T                    EN  M+  +
Sbjct: 53   HTYAVHCCCFSPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVM 92

Query: 898  DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 957
            +                  + + V  C  SP    +A G  +G + +    + ++++   
Sbjct: 93   EQP----------------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGS 136

Query: 958  QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL-------- 1009
                ++    F+ +    ++ S   ++ VW+ ++ +C+    H E   D  +        
Sbjct: 137  VKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQ 191

Query: 1010 --------LKNSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDA 1054
                    L+  RL S   D  VK+W +    I G + K       H   VL+C  SHD 
Sbjct: 192  PVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDG 251

Query: 1055 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1111
                S S DK+  ++  +    LH L  H   V   AF+ ++ LLATG  +  + IW
Sbjct: 252  QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)

Query: 921  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 979
            V CCC SP    +A    +G   +    N ++     Q   +   + QF+ D   L S +
Sbjct: 57   VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116

Query: 980  DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1031
             D  + +WN Q  K ++  G   +VKD  L         S  ++ S  G + VW+  +  
Sbjct: 117  ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172

Query: 1032 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1078
             + EK    H   +  CD S              + +S   D   KIW  SF  +L    
Sbjct: 173  LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229

Query: 1079 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1134
                 L GH   V   AFS D  +L +G  +  + +++ +   +LH            H 
Sbjct: 230  KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281

Query: 1135 GWVTDLCFSPDGKMLISAGGYIKWWNV 1161
             +VT   F+P+  +L++ G   K  N+
Sbjct: 282  RYVTTCAFAPN-TLLLATGSMDKTVNI 307



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)

Query: 1049 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1103
            D++  A  FS   + S DKT +++S      LP   L+ H   V C  FS    +LA+  
Sbjct: 14   DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73

Query: 1104 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1161
             +G   +WN  NG++L +    S       G  V    FSPD   L S  A G +  WN 
Sbjct: 74   TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126

Query: 1162 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1200
             + +  +       +L     SP+   +VT  + G L +
Sbjct: 127  QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165



 Score = 38.1 bits (87), Expect = 0.051
 Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)

Query: 1077 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1135
            +H L  H   V C AFS   +LLAT   +  IR++++ +  EL H  +PL     A H  
Sbjct: 5    IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58

Query: 1136 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1185
                 CFSP G +L S    G    WN   G+        +G+ ++    SPD
Sbjct: 59   ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 51/164 (31%), Positives = 83/164 (50%), Gaps = 2/164 (1%)

Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
           H   V+   FS  G    S G D+  +++  +  + L     H  +V C  F  +  ++A
Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643

Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
           T S D+ V++W+ + G  V  +  H   ++   F+ +     LATG++D  + LWD+   
Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR--FLATGATDGRVLLWDIGHG 701

Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 777
                + GHT++V   RFS D ++LAS S D T++LWDA  A E
Sbjct: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFE 745



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 58/232 (25%), Positives = 103/232 (44%), Gaps = 16/232 (6%)

Query: 640 QVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHS 699
           ++   +T  +L  +  H   V   +FS D  ++ + S D  V++W+  T   +  Y  H+
Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHN 585

Query: 700 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 759
             V    F+   ++ +  +G  D   +LW  +  +      GH   VN  RF P+   +A
Sbjct: 586 YPVWDTQFSPYGYYFV--SGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643

Query: 760 SCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN 819
           + SAD T++LWD  + N        + F   + P       +   ++S +G  +   A +
Sbjct: 644 TGSADRTVRLWDVLNGN------CVRIFTGHKGP-------IHSLTFSPNGRFLATGATD 690

Query: 820 -KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 870
            ++ LW+      V + +GH   V  + FS DG    + S D T+RLW+  K
Sbjct: 691 GRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 73/293 (24%), Positives = 128/293 (43%), Gaps = 48/293 (16%)

Query: 754  DDKLLASCSADGTLKLWDATSANERKSINVKQFF-LNLEDPQEDMEVIVKCCSWSADGAR 812
            D  L+A   AD T+++W  T    +K  +VKQ   L+L D + D +V+           R
Sbjct: 481  DSSLIAGGFADSTVRVWSVTP---KKLRSVKQASDLSLIDKESD-DVL----------ER 526

Query: 813  IMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVC 872
            IM          +  + S++    GH   V+G  FSPD +  L+SS+D T+RLW  +   
Sbjct: 527  IM----------DEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576

Query: 873  -------KNSAVMLKQEVDVVF------QENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 919
                    N  V   Q     +       +    + A DH + L++  G          A
Sbjct: 577  CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHL--------A 628

Query: 920  QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 979
             V+C    P+  Y+A G  +  + + +++N    +    HK  +  + F+ + + L + +
Sbjct: 629  DVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGA 688

Query: 980  DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNII 1030
             D  + +W+      +  L+GH +TV   R  ++  +L S S D TV++W+ I
Sbjct: 689  TDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 63/268 (23%), Positives = 112/268 (41%), Gaps = 14/268 (5%)

Query: 850  DGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENE-VMVLAVDH--IRRLQLI 906
            D S       D T+R+W      K  +V    ++ ++ +E++ V+   +D      L+++
Sbjct: 481  DSSLIAGGFADSTVRVWSVTPK-KLRSVKQASDLSLIDKESDDVLERIMDEKTASELKIL 539

Query: 907  NGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI 966
             G +G         V     SP   Y+    E+G + +  L           H   VW  
Sbjct: 540  YGHSGP--------VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDT 591

Query: 967  QFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRLLSW-SFDGTV 1024
            QF+      +S   D   ++W     + +    GH   V   R   NS  ++  S D TV
Sbjct: 592  QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV 651

Query: 1025 KVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHN 1084
            ++W+++ GN  + F  H+G + S   S +    ++ + D    +W     L + EL+GH 
Sbjct: 652  RLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHT 711

Query: 1085 GCVRCSAFSVDSTLLATGDDNGEIRIWN 1112
              V    FS D  +LA+G  +  +R+W+
Sbjct: 712  DTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 46/152 (30%), Positives = 71/152 (46%), Gaps = 10/152 (6%)

Query: 1015 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1074
            LLS S DGTV++W++ T      +  H   V     S     F S   D+ A++W+ D  
Sbjct: 558  LLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHY 617

Query: 1075 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1134
             PL    GH   V C+ F  +S  +ATG  +  +R+W+V NG  + +           H 
Sbjct: 618  QPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRI--------FTGHK 669

Query: 1135 GWVTDLCFSPDGKMLISAG--GYIKWWNVVTG 1164
            G +  L FSP+G+ L +    G +  W++  G
Sbjct: 670  GPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 72/322 (22%), Positives = 126/322 (39%), Gaps = 64/322 (19%)

Query: 668 DDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 727
           D   IA    D  V++W S+T + + +  + S+              L+   S D   ++
Sbjct: 481 DSSLIAGGFADSTVRVW-SVTPKKLRSVKQASDLS------------LIDKESDDVLERI 527

Query: 728 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFF 787
            D         ++GH+  V    FSPD   L S S DGT++LW   +      +  K   
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT--CLVGYKGHN 585

Query: 788 LNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVM 846
             + D Q           +S  G   +    +++  LW TD    +    GHL+ V+   
Sbjct: 586 YPVWDTQ-----------FSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTR 634

Query: 847 FSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLI 906
           F P+ +   T S D+T+RLW+   V   + V                          ++ 
Sbjct: 635 FHPNSNYVATGSADRTVRLWD---VLNGNCV--------------------------RIF 665

Query: 907 NGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI 966
            G  G I  LT         SP+ +++A G  +G + + ++ +  +      H  TV  +
Sbjct: 666 TGHKGPIHSLT--------FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSL 717

Query: 967 QFTADEKTLISSSDDAEIQVWN 988
           +F+ D + L S S D  +++W+
Sbjct: 718 RFSRDGEILASGSMDNTVRLWD 739



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 35/110 (31%), Positives = 49/110 (44%), Gaps = 20/110 (18%)

Query: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
           ++ HTD V    FS DG+ +AS   D T++++ A        IKA ED        TDD 
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA--------IKAFED------LETDDF 752

Query: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720
             AT  ++        + G    TY   S  V   HFT    +L+LA G+
Sbjct: 753 TTATGHINLPENSQELLLG----TYMTKSTPVVHLHFTR--RNLVLAAGA 796


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.134    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,589,652
Number of Sequences: 37866
Number of extensions: 2024919
Number of successful extensions: 10239
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 211
Number of HSP's successfully gapped in prelim test: 112
Number of HSP's that attempted gapping in prelim test: 4985
Number of HSP's gapped (non-prelim): 2592
length of query: 1205
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1091
effective length of database: 13,930,794
effective search space: 15198496254
effective search space used: 15198496254
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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