Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 32189425
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32189425 WD repeat domain 69 [Homo sapiens]
(415 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32189425 WD repeat domain 69 [Homo sapiens] 850 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 186 3e-47
gi|16554627 WD repeat domain 5 [Homo sapiens] 186 3e-47
gi|23199987 WD repeat domain 5B [Homo sapiens] 186 3e-47
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 184 2e-46
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 184 2e-46
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 184 2e-46
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 164 1e-40
gi|113865883 WD repeat domain 38 [Homo sapiens] 164 2e-40
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 162 5e-40
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 162 5e-40
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 162 7e-40
gi|26665869 WD repeat domain 51B [Homo sapiens] 159 3e-39
gi|157266266 WD repeat domain 86 [Homo sapiens] 152 4e-37
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 151 1e-36
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 150 3e-36
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 145 5e-35
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 144 1e-34
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 144 1e-34
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 144 1e-34
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 144 1e-34
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 144 1e-34
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 142 4e-34
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 140 3e-33
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 139 5e-33
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 138 8e-33
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 138 8e-33
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 138 8e-33
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 138 8e-33
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 137 2e-32
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 850 bits (2196), Expect = 0.0
Identities = 415/415 (100%), Positives = 415/415 (100%)
Query: 1 MKLKSLLLRYYPPGIMLEYEKHGELKTKSIDLLDLGPSTDVSALVEEIQKAEPLLTASRT 60
MKLKSLLLRYYPPGIMLEYEKHGELKTKSIDLLDLGPSTDVSALVEEIQKAEPLLTASRT
Sbjct: 1 MKLKSLLLRYYPPGIMLEYEKHGELKTKSIDLLDLGPSTDVSALVEEIQKAEPLLTASRT 60
Query: 61 EQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD 120
EQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD
Sbjct: 61 EQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD 120
Query: 121 TASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEI 180
TASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEI
Sbjct: 121 TASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEI 180
Query: 181 VCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFD 240
VCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFD
Sbjct: 181 VCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFD 240
Query: 241 HTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT 300
HTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT
Sbjct: 241 HTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT 300
Query: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHL 360
GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHL
Sbjct: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHL 360
Query: 361 LTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
LTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR
Sbjct: 361 LTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 186 bits (473), Expect = 3e-47
Identities = 100/293 (34%), Positives = 161/293 (54%), Gaps = 7/293 (2%)
Query: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188
TL GH V ++ F+ P G+ +A+ S DK K+W GK T GH I ++++
Sbjct: 40 TLAGHTKAVSSVKFS-PNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 189 STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA 248
S L+ + S D T K+WD+ +G+ + TL+GHS + +FN + I++GSFD +V +WD
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 249 DTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILD 308
TG+ + L H +S+ FN D SLI++ S D C++WD +G+C+ TL D+ +
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218
Query: 309 SC-FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN---PQGNHLLTGS 364
F GK I A+ D T +++ + KC+ GH+ E I N G +++GS
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278
Query: 365 SDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS--KDNTCRIWR 415
D IW+ QT + +Q L+GHTD + S A + NI+ + + D T ++W+
Sbjct: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 175 bits (443), Expect = 8e-44
Identities = 91/291 (31%), Positives = 161/291 (55%), Gaps = 7/291 (2%)
Query: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
L H +++V + +G + S D+ K+W G+ T+ GH+ + +A+++
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD-S 99
Query: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
+ + + S DKT K+W V +GKC T +GH+ + C +FNPQS L+ +GS D + ++WD++
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI-GHCAEISS 266
G+ + TL HS + ++ FN G I++ S+D +WD +G+ + LI +S
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219
Query: 267 ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE--ILDSCFDYT-GKLIATASA 323
F+ + IL ++D T KLWD + GKC+ T TGH +E + + F T GK I + S
Sbjct: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279
Query: 324 DGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGS--SDKTARIW 372
D I++ T++ + KL+GH + + +P N + + + +DKT ++W
Sbjct: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 138 bits (347), Expect = 1e-32
Identities = 74/248 (29%), Positives = 131/248 (52%), Gaps = 5/248 (2%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
K + H L +++VA + + ++ S D+T K+WD +SG+ L TL+GH N V+ F NP
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF-NP 139
Query: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
+ I +GSFD++ ++W V+TGKC T H+ + + FN +L+ + S D ++WD
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Query: 206 IQNGEEVYTLRGHSAEIIS-LSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEI 264
+G+ + TL +S + F+ +G I+ + D+T+ +WD G+ + GH E
Sbjct: 200 TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK 259
Query: 265 SSASFNWDCS---LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATA 321
N+ + I++GS D +W+ + V L GH D ++ + T +IA+A
Sbjct: 260 YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA 319
Query: 322 SADGTARI 329
+ + I
Sbjct: 320 ALENDKTI 327
Score = 136 bits (343), Expect = 3e-32
Identities = 72/229 (31%), Positives = 120/229 (52%), Gaps = 5/229 (2%)
Query: 187 PQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
P + AT S T K N +TL GH+ + S+ F+ +G+ + + S D + +W
Sbjct: 17 PTPSSSATQSKPTPVK----PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
Query: 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI 306
A G+ + GH IS +++ D +L+++ S DKT K+WD ++GKC+ TL GH + +
Sbjct: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132
Query: 307 LDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSD 366
F+ LI + S D + RI+ T KC+ L H +S + FN G+ +++ S D
Sbjct: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192
Query: 367 KTARIWDAQTGQCLQVL-EGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
RIWD +GQCL+ L + + F+ G ++ + DNT ++W
Sbjct: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 105 bits (262), Expect = 8e-23
Identities = 58/169 (34%), Positives = 88/169 (52%), Gaps = 5/169 (2%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
K L AH P++ V N+ GS ++ SYD C++WDTASG+ L TL N + +P
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
Query: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST---LVATGSMDTTAK 202
G I + D T KLW GKC T+ GH E C+ N T + +GS D
Sbjct: 225 NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY 284
Query: 203 LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSF--DHTVVVWDAD 249
+W++Q E V L+GH+ +IS + + + + I + + D T+ +W +D
Sbjct: 285 IWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 186 bits (473), Expect = 3e-47
Identities = 100/293 (34%), Positives = 161/293 (54%), Gaps = 7/293 (2%)
Query: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188
TL GH V ++ F+ P G+ +A+ S DK K+W GK T GH I ++++
Sbjct: 40 TLAGHTKAVSSVKFS-PNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 189 STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA 248
S L+ + S D T K+WD+ +G+ + TL+GHS + +FN + I++GSFD +V +WD
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 249 DTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILD 308
TG+ + L H +S+ FN D SLI++ S D C++WD +G+C+ TL D+ +
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218
Query: 309 SC-FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN---PQGNHLLTGS 364
F GK I A+ D T +++ + KC+ GH+ E I N G +++GS
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278
Query: 365 SDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS--KDNTCRIWR 415
D IW+ QT + +Q L+GHTD + S A + NI+ + + D T ++W+
Sbjct: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 175 bits (443), Expect = 8e-44
Identities = 91/291 (31%), Positives = 161/291 (55%), Gaps = 7/291 (2%)
Query: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
L H +++V + +G + S D+ K+W G+ T+ GH+ + +A+++
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD-S 99
Query: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
+ + + S DKT K+W V +GKC T +GH+ + C +FNPQS L+ +GS D + ++WD++
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI-GHCAEISS 266
G+ + TL HS + ++ FN G I++ S+D +WD +G+ + LI +S
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219
Query: 267 ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE--ILDSCFDYT-GKLIATASA 323
F+ + IL ++D T KLWD + GKC+ T TGH +E + + F T GK I + S
Sbjct: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279
Query: 324 DGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGS--SDKTARIW 372
D I++ T++ + KL+GH + + +P N + + + +DKT ++W
Sbjct: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 138 bits (347), Expect = 1e-32
Identities = 74/248 (29%), Positives = 131/248 (52%), Gaps = 5/248 (2%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
K + H L +++VA + + ++ S D+T K+WD +SG+ L TL+GH N V+ F NP
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF-NP 139
Query: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
+ I +GSFD++ ++W V+TGKC T H+ + + FN +L+ + S D ++WD
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Query: 206 IQNGEEVYTLRGHSAEIIS-LSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEI 264
+G+ + TL +S + F+ +G I+ + D+T+ +WD G+ + GH E
Sbjct: 200 TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK 259
Query: 265 SSASFNWDCS---LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATA 321
N+ + I++GS D +W+ + V L GH D ++ + T +IA+A
Sbjct: 260 YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA 319
Query: 322 SADGTARI 329
+ + I
Sbjct: 320 ALENDKTI 327
Score = 136 bits (343), Expect = 3e-32
Identities = 72/229 (31%), Positives = 120/229 (52%), Gaps = 5/229 (2%)
Query: 187 PQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
P + AT S T K N +TL GH+ + S+ F+ +G+ + + S D + +W
Sbjct: 17 PTPSSSATQSKPTPVK----PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
Query: 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI 306
A G+ + GH IS +++ D +L+++ S DKT K+WD ++GKC+ TL GH + +
Sbjct: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132
Query: 307 LDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSD 366
F+ LI + S D + RI+ T KC+ L H +S + FN G+ +++ S D
Sbjct: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192
Query: 367 KTARIWDAQTGQCLQVL-EGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
RIWD +GQCL+ L + + F+ G ++ + DNT ++W
Sbjct: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 105 bits (262), Expect = 8e-23
Identities = 58/169 (34%), Positives = 88/169 (52%), Gaps = 5/169 (2%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
K L AH P++ V N+ GS ++ SYD C++WDTASG+ L TL N + +P
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
Query: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST---LVATGSMDTTAK 202
G I + D T KLW GKC T+ GH E C+ N T + +GS D
Sbjct: 225 NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY 284
Query: 203 LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSF--DHTVVVWDAD 249
+W++Q E V L+GH+ +IS + + + + I + + D T+ +W +D
Sbjct: 285 IWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 186 bits (473), Expect = 3e-47
Identities = 100/292 (34%), Positives = 163/292 (55%), Gaps = 7/292 (2%)
Query: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188
TL GH V ++ F+ P G+ +A+ S D+ +W GK T GH EI ++++
Sbjct: 36 TLVGHTEAVSSVKFS-PNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD 94
Query: 189 STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA 248
S+ + + S D T KLWD+++G+ + TL+GHS + +FN + II+GSFD TV +W+
Sbjct: 95 SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEV 154
Query: 249 DTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILD 308
TG+ + L H +S+ FN SLI++GS D C++WDA +G+C+ TL D+ +
Sbjct: 155 KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVS 214
Query: 309 SC-FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN---PQGNHLLTGS 364
F GK I TA+ D T +++ + +C+ GH+ E I N G +++GS
Sbjct: 215 FVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 274
Query: 365 SDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS--KDNTCRIW 414
D IW+ QT + +Q L+GHTD + S A + N++ + + D T ++W
Sbjct: 275 EDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 180 bits (456), Expect = 2e-45
Identities = 97/300 (32%), Positives = 165/300 (55%), Gaps = 7/300 (2%)
Query: 79 NHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVY 138
N + L L H +++V + +G + S DR +W G+ TL GH +
Sbjct: 28 NPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEIS 87
Query: 139 AIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMD 198
+A+++ ++ + S DKT KLW V +GKC T +GH+ + C +FNP S L+ +GS D
Sbjct: 88 DVAWSSD-SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
Query: 199 TTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI 258
T K+W+++ G+ + TL HS + ++ FN SG I++GS+D +WDA +G+ + L+
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206
Query: 259 -GHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE--ILDSCFDYT- 314
+S F+ + ILT ++D T KLWD + G+C+ T TGH +E + + F T
Sbjct: 207 DDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG 266
Query: 315 GKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGS--SDKTARIW 372
GK I + S D I++ T++ + KL+GH + + +P N + + + +DKT ++W
Sbjct: 267 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 97.8 bits (242), Expect = 2e-20
Identities = 48/140 (34%), Positives = 83/140 (59%)
Query: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAAT 334
L L+ S +++ ++ + N TL GH + + F G+ +A++SAD I+ A
Sbjct: 13 LALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYD 72
Query: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCA 394
K L GH EIS ++++ + L++ S DKT ++WD ++G+CL+ L+GH++ +F C
Sbjct: 73 GKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN 132
Query: 395 FNYKGNIVITGSKDNTCRIW 414
FN N++I+GS D T +IW
Sbjct: 133 FNPPSNLIISGSFDETVKIW 152
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 184 bits (466), Expect = 2e-46
Identities = 100/301 (33%), Positives = 172/301 (57%), Gaps = 17/301 (5%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
KVLK H + L G+ ++GS D T K+W +G+ L TL GH V++ +
Sbjct: 256 KVLKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD- 313
Query: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
+ I +GS D+T K+W+ ETG+C HT GHT+ + C+ + + V +GS D T ++WD
Sbjct: 314 --NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 369
Query: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEIS 265
I+ G+ ++ L GH A + + ++ G R+++G++D V VWD +T ++ L GH +
Sbjct: 370 IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 427
Query: 266 SASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325
S F D +++GS+D + ++WD G C+ TLTGH + L S + ++ + +AD
Sbjct: 428 SLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGH--QSLTSGMELKDNILVSGNADS 483
Query: 326 TARIFSAATRKCIAKLEG---HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
T +I+ T +C+ L+G H+ ++ + FN N ++T S D T ++WD +TG+ ++
Sbjct: 484 TVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRN 541
Query: 383 L 383
L
Sbjct: 542 L 542
Score = 176 bits (447), Expect = 3e-44
Identities = 101/300 (33%), Positives = 163/300 (54%), Gaps = 19/300 (6%)
Query: 119 WDTASGEELNTLEGHRN-VVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHT 177
W + L+GH + V+ + F G++I +GS D T K+WS TGKC T GHT
Sbjct: 247 WRRGELKSPKVLKGHDDHVITCLQF---CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHT 303
Query: 178 AEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITG 237
+ S + ++ +GS D T K+W+ + GE ++TL GH++ + + + R+++G
Sbjct: 304 GGV--WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSG 359
Query: 238 SFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVA 297
S D T+ VWD +TG+ +++L+GH A + + D +++G+ D K+WD C+
Sbjct: 360 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 417
Query: 298 TLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG 357
TL GH + + FD G + + S D + R++ T CI L GH+ S + +
Sbjct: 418 TLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KD 473
Query: 358 NHLLTGSSDKTARIWDAQTGQCLQVLEG---HTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
N L++G++D T +IWD +TGQCLQ L+G H + FN N VIT S D T ++W
Sbjct: 474 NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLW 531
Score = 108 bits (269), Expect = 1e-23
Identities = 60/175 (34%), Positives = 98/175 (56%), Gaps = 12/175 (6%)
Query: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146
VL H+ + V + G ++G+YD K+WD + L+TL+GH N VY++ F+
Sbjct: 378 VLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--- 432
Query: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
G + +GS D + ++W VETG C HT GH + + + ++ +G+ D+T K+WDI
Sbjct: 433 GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKIWDI 490
Query: 207 QNGEEVYTLRG---HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI 258
+ G+ + TL+G H + + L FN + +IT S D TV +WD TG + L+
Sbjct: 491 KTGQCLQTLQGPNKHQSAVTCLQFNKNF--VITSSDDGTVKLWDLKTGEFIRNLV 543
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 184 bits (466), Expect = 2e-46
Identities = 100/301 (33%), Positives = 172/301 (57%), Gaps = 17/301 (5%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
KVLK H + L G+ ++GS D T K+W +G+ L TL GH V++ +
Sbjct: 374 KVLKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD- 431
Query: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
+ I +GS D+T K+W+ ETG+C HT GHT+ + C+ + + V +GS D T ++WD
Sbjct: 432 --NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 487
Query: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEIS 265
I+ G+ ++ L GH A + + ++ G R+++G++D V VWD +T ++ L GH +
Sbjct: 488 IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
Query: 266 SASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325
S F D +++GS+D + ++WD G C+ TLTGH + L S + ++ + +AD
Sbjct: 546 SLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGH--QSLTSGMELKDNILVSGNADS 601
Query: 326 TARIFSAATRKCIAKLEG---HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
T +I+ T +C+ L+G H+ ++ + FN N ++T S D T ++WD +TG+ ++
Sbjct: 602 TVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRN 659
Query: 383 L 383
L
Sbjct: 660 L 660
Score = 176 bits (447), Expect = 3e-44
Identities = 101/300 (33%), Positives = 163/300 (54%), Gaps = 19/300 (6%)
Query: 119 WDTASGEELNTLEGHRN-VVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHT 177
W + L+GH + V+ + F G++I +GS D T K+WS TGKC T GHT
Sbjct: 365 WRRGELKSPKVLKGHDDHVITCLQF---CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHT 421
Query: 178 AEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITG 237
+ S + ++ +GS D T K+W+ + GE ++TL GH++ + + + R+++G
Sbjct: 422 GGV--WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSG 477
Query: 238 SFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVA 297
S D T+ VWD +TG+ +++L+GH A + + D +++G+ D K+WD C+
Sbjct: 478 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 535
Query: 298 TLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG 357
TL GH + + FD G + + S D + R++ T CI L GH+ S + +
Sbjct: 536 TLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KD 591
Query: 358 NHLLTGSSDKTARIWDAQTGQCLQVLEG---HTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
N L++G++D T +IWD +TGQCLQ L+G H + FN N VIT S D T ++W
Sbjct: 592 NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLW 649
Score = 108 bits (269), Expect = 1e-23
Identities = 60/175 (34%), Positives = 98/175 (56%), Gaps = 12/175 (6%)
Query: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146
VL H+ + V + G ++G+YD K+WD + L+TL+GH N VY++ F+
Sbjct: 496 VLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--- 550
Query: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
G + +GS D + ++W VETG C HT GH + + + ++ +G+ D+T K+WDI
Sbjct: 551 GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKIWDI 608
Query: 207 QNGEEVYTLRG---HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI 258
+ G+ + TL+G H + + L FN + +IT S D TV +WD TG + L+
Sbjct: 609 KTGQCLQTLQGPNKHQSAVTCLQFNKNF--VITSSDDGTVKLWDLKTGEFIRNLV 661
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 184 bits (466), Expect = 2e-46
Identities = 100/301 (33%), Positives = 172/301 (57%), Gaps = 17/301 (5%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
KVLK H + L G+ ++GS D T K+W +G+ L TL GH V++ +
Sbjct: 294 KVLKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD- 351
Query: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
+ I +GS D+T K+W+ ETG+C HT GHT+ + C+ + + V +GS D T ++WD
Sbjct: 352 --NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 407
Query: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEIS 265
I+ G+ ++ L GH A + + ++ G R+++G++D V VWD +T ++ L GH +
Sbjct: 408 IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 465
Query: 266 SASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325
S F D +++GS+D + ++WD G C+ TLTGH + L S + ++ + +AD
Sbjct: 466 SLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGH--QSLTSGMELKDNILVSGNADS 521
Query: 326 TARIFSAATRKCIAKLEG---HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
T +I+ T +C+ L+G H+ ++ + FN N ++T S D T ++WD +TG+ ++
Sbjct: 522 TVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRN 579
Query: 383 L 383
L
Sbjct: 580 L 580
Score = 176 bits (447), Expect = 3e-44
Identities = 101/300 (33%), Positives = 163/300 (54%), Gaps = 19/300 (6%)
Query: 119 WDTASGEELNTLEGHRN-VVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHT 177
W + L+GH + V+ + F G++I +GS D T K+WS TGKC T GHT
Sbjct: 285 WRRGELKSPKVLKGHDDHVITCLQF---CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHT 341
Query: 178 AEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITG 237
+ S + ++ +GS D T K+W+ + GE ++TL GH++ + + + R+++G
Sbjct: 342 GGV--WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSG 397
Query: 238 SFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVA 297
S D T+ VWD +TG+ +++L+GH A + + D +++G+ D K+WD C+
Sbjct: 398 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 455
Query: 298 TLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG 357
TL GH + + FD G + + S D + R++ T CI L GH+ S + +
Sbjct: 456 TLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KD 511
Query: 358 NHLLTGSSDKTARIWDAQTGQCLQVLEG---HTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
N L++G++D T +IWD +TGQCLQ L+G H + FN N VIT S D T ++W
Sbjct: 512 NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLW 569
Score = 108 bits (269), Expect = 1e-23
Identities = 60/175 (34%), Positives = 98/175 (56%), Gaps = 12/175 (6%)
Query: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146
VL H+ + V + G ++G+YD K+WD + L+TL+GH N VY++ F+
Sbjct: 416 VLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--- 470
Query: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
G + +GS D + ++W VETG C HT GH + + + ++ +G+ D+T K+WDI
Sbjct: 471 GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKIWDI 528
Query: 207 QNGEEVYTLRG---HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI 258
+ G+ + TL+G H + + L FN + +IT S D TV +WD TG + L+
Sbjct: 529 KTGQCLQTLQGPNKHQSAVTCLQFNKNF--VITSSDDGTVKLWDLKTGEFIRNLV 581
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 164 bits (415), Expect = 1e-40
Identities = 92/311 (29%), Positives = 149/311 (47%), Gaps = 25/311 (8%)
Query: 126 ELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSF 185
E L GHR+ V + F+ P + + S D T K+W ETG T +GHT + +SF
Sbjct: 100 EKYALSGHRSPVTRVIFH-PVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISF 158
Query: 186 NPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVV 245
+ L+A+ S D T KLWD Q E + T+ GH + S++ +GD I++ S D T+ +
Sbjct: 159 DHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKM 218
Query: 246 WDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE 305
W+ TG V GH + N D +LI + S D+T ++W +C A L H+
Sbjct: 219 WEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHV 278
Query: 306 ILDSCFDYT----------------------GKLIATASADGTARIFSAATRKCIAKLEG 343
+ C + G + + S D T +++ +T C+ L G
Sbjct: 279 V--ECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG 336
Query: 344 HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVI 403
H+ + + F+ G +L+ + DKT R+WD + +C++ L H + S F+ V+
Sbjct: 337 HDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVV 396
Query: 404 TGSKDNTCRIW 414
TGS D T ++W
Sbjct: 397 TGSVDQTVKVW 407
Score = 158 bits (400), Expect = 8e-39
Identities = 92/308 (29%), Positives = 148/308 (48%), Gaps = 21/308 (6%)
Query: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
L H P+T V + S ++ S D T K+WD +G+ TL+GH + V I+F++ G
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS-G 162
Query: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
+A+ S D T KLW + +C T GH + ++ P + + S D T K+W++Q
Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQ 222
Query: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA 267
G V T GH + + N G I + S D TV VW T L H +
Sbjct: 223 TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECI 282
Query: 268 SFNWDCS--------------------LILTGSMDKTCKLWDATNGKCVATLTGHDDEIL 307
S+ + S +L+GS DKT K+WD + G C+ TL GHD+ +
Sbjct: 283 SWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVR 342
Query: 308 DSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDK 367
F GK I + + D T R++ ++C+ L HE ++ + F+ +++TGS D+
Sbjct: 343 GVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQ 402
Query: 368 TARIWDAQ 375
T ++W+ +
Sbjct: 403 TVKVWECR 410
Score = 136 bits (342), Expect = 4e-32
Identities = 83/265 (31%), Positives = 128/265 (48%), Gaps = 21/265 (7%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
+ LK H + +++ + SG + S D T KLWD E + T+ GH + V ++A P
Sbjct: 144 RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAI-MP 202
Query: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
GD I + S DKT K+W V+TG C TF GH + + N TL+A+ S D T ++W
Sbjct: 203 NGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWV 262
Query: 206 IQNGEEVYTLRGHS--AEIISLSFNTS------------------GDRIITGSFDHTVVV 245
+ E LR H E IS + +S G +++GS D T+ +
Sbjct: 263 VATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKM 322
Query: 246 WDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE 305
WD TG + L+GH + F+ IL+ + DKT ++WD N +C+ TL H+
Sbjct: 323 WDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHF 382
Query: 306 ILDSCFDYTGKLIATASADGTARIF 330
+ F T + T S D T +++
Sbjct: 383 VTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 110 bits (275), Expect = 2e-24
Identities = 65/228 (28%), Positives = 113/228 (49%), Gaps = 21/228 (9%)
Query: 82 FYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIA 141
F + + H +++VA+ +G ++ S D+T K+W+ +G + T GHR V +
Sbjct: 182 FECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVR 241
Query: 142 FNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST----------- 190
N G IA+ S D+T ++W V T +C R H + C+S+ P+S+
Sbjct: 242 PNQD-GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE 300
Query: 191 ---------LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDH 241
+ +GS D T K+WD+ G + TL GH + + F++ G I++ + D
Sbjct: 301 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 360
Query: 242 TVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD 289
T+ VWD R + L H ++S F+ ++TGS+D+T K+W+
Sbjct: 361 TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 83.6 bits (205), Expect = 3e-16
Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 19/186 (10%)
Query: 81 TFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI 140
T Y K H + V N+ G+ + S D+T ++W A+ E L H +VV I
Sbjct: 223 TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECI 282
Query: 141 AF-------------------NNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIV 181
++ + G + +GS DKT K+W V TG C T GH +
Sbjct: 283 SWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVR 342
Query: 182 CLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDH 241
+ F+ + + + D T ++WD +N + TL H + SL F+ + ++TGS D
Sbjct: 343 GVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQ 402
Query: 242 TVVVWD 247
TV VW+
Sbjct: 403 TVKVWE 408
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 164 bits (414), Expect = 2e-40
Identities = 88/283 (31%), Positives = 144/283 (50%), Gaps = 5/283 (1%)
Query: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLV 192
H V + AF+ P G + TGS D W +G+ GHT + F+P L
Sbjct: 20 HGGEVNSSAFS-PDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR 252
A+ S D T +LWD+ + + L+GH + ++SF+ ++ +G +D V++WD +G+
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
Query: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD---ATNGKCVATLTGHDDEILDS 309
+ +L+GH I S+ F+ + + TGS D T +WD T L GH I
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
Query: 310 CFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTA 369
C+ +G L+A+ S D T I+ T + +L+GH + I+F+P L + +
Sbjct: 199 CYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMV 257
Query: 370 RIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412
++WD TG+CL+ L+G D +CAF G I+++G+ D T R
Sbjct: 258 KVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 143 bits (360), Expect = 3e-34
Identities = 88/275 (32%), Positives = 131/275 (47%), Gaps = 5/275 (1%)
Query: 99 ALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKT 158
A + G +TGS D W+T SG+ L L GH V F +P G A+ S D T
Sbjct: 28 AFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF-SPDGHLFASASCDCT 86
Query: 159 CKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGH 218
+LW V KC +GH + +SF+P S +A+G D LWD+Q+G+ + L GH
Sbjct: 87 VRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGH 146
Query: 219 SAEIISLSFNTSGDRIITGSFDHTVVVWD---ADTGRKVNILIGHCAEISSASFNWDCSL 275
I S F+ + + + TGS+D TV +WD L GH A IS ++ L
Sbjct: 147 RDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYS-ASGL 205
Query: 276 ILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR 335
+ +GS DKT +W T + L GH + F +A+A +++ T
Sbjct: 206 LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTG 265
Query: 336 KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370
KC+ L+G +F P G L++G++D+T R
Sbjct: 266 KCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 134 bits (338), Expect = 1e-31
Identities = 79/251 (31%), Positives = 125/251 (49%), Gaps = 5/251 (1%)
Query: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
L H P+ + G F + S D T +LWD A + L L+GH+ V ++F+ P
Sbjct: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFS-PDS 117
Query: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
++A+G +DK LW V++G+ GH I F+P +ATGS D+T +WD++
Sbjct: 118 RQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177
Query: 208 NGEEVYT---LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEI 264
+ L GHSA I L ++ SG + +GS+D T+ +W T + L GH +
Sbjct: 178 MVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWV 236
Query: 265 SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASAD 324
S +F+ D + + + K+WD GKC+ TL G D F GK++ + +AD
Sbjct: 237 KSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
Query: 325 GTARIFSAATR 335
T R S ++
Sbjct: 297 QTRRQISRTSK 307
Score = 116 bits (291), Expect = 3e-26
Identities = 60/163 (36%), Positives = 90/163 (55%)
Query: 252 RKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCF 311
R+V H E++S++F+ D ++LTGS D W+ +G+ + L GH + F
Sbjct: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF 71
Query: 312 DYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARI 371
G L A+AS D T R++ A KC+ L+GH+ + +SF+P L +G DK +
Sbjct: 72 SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131
Query: 372 WDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
WD Q+GQ L++L GH D I S F+ N + TGS D+T IW
Sbjct: 132 WDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
Score = 105 bits (261), Expect = 1e-22
Identities = 62/201 (30%), Positives = 92/201 (45%), Gaps = 4/201 (1%)
Query: 218 HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLIL 277
H E+ S +F+ G ++TGS D V W+ +G+ + L GH + F+ D L
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 278 TGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC 337
+ S D T +LWD KC+ L GH + F + +A+ D ++ + +
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 338 IAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT---GQCLQVLEGHTDEIFSCA 394
+ L GH I F+P N L TGS D T IWD + Q LEGH+ I SC
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI-SCL 198
Query: 395 FNYKGNIVITGSKDNTCRIWR 415
++ +GS D T IW+
Sbjct: 199 CYSASGLLASGSWDKTIHIWK 219
Score = 101 bits (251), Expect = 1e-21
Identities = 59/202 (29%), Positives = 102/202 (50%), Gaps = 5/202 (2%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
+VLK H + V+ + +G +D+ LWD SG+ L L GHR+ + + F +P
Sbjct: 99 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDF-SP 157
Query: 146 YGDKIATGSFDKTCKLWS---VETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAK 202
+ +ATGS+D T +W V + GH+A I CL ++ S L+A+GS D T
Sbjct: 158 TVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYS-ASGLLASGSWDKTIH 216
Query: 203 LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCA 262
+W + L+GH + S++F+ + + + V VWD +TG+ + L G
Sbjct: 217 IWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLD 276
Query: 263 EISSASFNWDCSLILTGSMDKT 284
+ +F D ++++G+ D+T
Sbjct: 277 VAHTCAFTPDGKILVSGAADQT 298
Score = 70.5 bits (171), Expect = 3e-12
Identities = 39/162 (24%), Positives = 74/162 (45%), Gaps = 5/162 (3%)
Query: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD---TASGEELNTLEGHRNVVYAI 140
+ ++L H + + + + +C TGS+D T +WD LEGH + +
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
Query: 141 AFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTT 200
++ +A+GS+DKT +W T +GH + ++F+P +A+
Sbjct: 199 CYS--ASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRM 256
Query: 201 AKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHT 242
K+WD G+ + TL+G + +F G +++G+ D T
Sbjct: 257 VKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 162 bits (410), Expect = 5e-40
Identities = 88/285 (30%), Positives = 143/285 (50%), Gaps = 1/285 (0%)
Query: 131 EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST 190
+GHR+ V + F+ ++A+GS D +W ++ + F GH + C++F+P
Sbjct: 16 KGHRDAVTCVDFSINT-KQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT 250
L+A+GS D T ++W E R H+A + S+ F + G +T S D TV VW
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310
+ + L H + A F+ D LI++ S DKT KLWD ++ +CV + H +
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370
F +G IA A D T +++ T + + + H ++ +SF+P GN+L+T SSD T +
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
Query: 371 IWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
I D G+ L L GH + AF+ G +G D +W+
Sbjct: 255 ILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 139 bits (351), Expect = 4e-33
Identities = 70/241 (29%), Positives = 126/241 (52%)
Query: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232
F+GH + C+ F+ + +A+GSMD+ +W ++ Y GH + ++F+ SG
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
+ +GS D TV +W + + + H A + S F D +T S DKT K+W
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
K + +L+ H + + + F G+LI +AS D T +++ ++R+C+ H G ++ +
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412
F+P G + D T ++WD +T + LQ + H+ + +F+ GN +IT S D+T +
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
Query: 413 I 413
I
Sbjct: 255 I 255
Score = 120 bits (302), Expect = 2e-27
Identities = 73/284 (25%), Positives = 123/284 (43%), Gaps = 1/284 (0%)
Query: 89 KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGD 148
K H +T V + + +GS D +W GH++ V + F +P G
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF-SPSGH 74
Query: 149 KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN 208
+A+GS DKT ++W FR HTA + + F T S D T K+W
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 209 GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSAS 268
+ +++L H + F+ G I++ S D TV +WD + V+ H ++
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 269 FNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTAR 328
F+ + I MD T K+WD + + H + F +G + TAS+D T +
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
Query: 329 IFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
I + + L GH+G + ++F+ G + +G SD+ +W
Sbjct: 255 ILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 117 bits (292), Expect = 3e-26
Identities = 69/238 (28%), Positives = 108/238 (45%), Gaps = 1/238 (0%)
Query: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
+T V + SG +GS D+T ++W E H V ++ F + G T S
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD-GQSFVTAS 122
Query: 155 FDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYT 214
DKT K+W+ K + H + C F+P L+ + S D T KLWD + E V++
Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
Query: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274
H + + F+ SG I D+TV VWD T R + H A ++ SF+ +
Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242
Query: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA 332
++T S D T K+ D G+ + TL GH F TG+ A+ +D ++ +
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
Score = 116 bits (291), Expect = 3e-26
Identities = 65/202 (32%), Positives = 102/202 (50%), Gaps = 1/202 (0%)
Query: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146
V +AH + +V G F+T S D+T K+W T + L +L H N V F +P
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF-SPD 156
Query: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
G I + S DKT KLW + +C H++ H + + F+P T +A MD T K+WD+
Sbjct: 157 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
Query: 207 QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266
+ + + HSA + LSF+ SG+ +IT S D T+ + D GR + L GH ++
Sbjct: 217 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 276
Query: 267 ASFNWDCSLILTGSMDKTCKLW 288
+F+ +G D+ +W
Sbjct: 277 VAFSRTGEYFASGGSDEQVMVW 298
Score = 96.7 bits (239), Expect = 4e-20
Identities = 59/198 (29%), Positives = 98/198 (49%), Gaps = 12/198 (6%)
Query: 52 EPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGS 111
+ +TAS + VK+ Q+ +LF L HI + + G ++ S
Sbjct: 116 QSFVTASDDKTVKVWATHRQK----------FLFS-LSQHINWVRCAKFSPDGRLIVSAS 164
Query: 112 YDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYH 171
D+T KLWD +S E +++ H V + F+ P G IA D T K+W V T +
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH-PSGTCIAAAGMDNTVKVWDVRTHRLLQ 223
Query: 172 TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSG 231
++ H+A + LSF+P + T S D+T K+ D+ G +YTL GH +++F+ +G
Sbjct: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283
Query: 232 DRIITGSFDHTVVVWDAD 249
+ +G D V+VW ++
Sbjct: 284 EYFASGGSDEQVMVWKSN 301
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 162 bits (410), Expect = 5e-40
Identities = 88/285 (30%), Positives = 143/285 (50%), Gaps = 1/285 (0%)
Query: 131 EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST 190
+GHR+ V + F+ ++A+GS D +W ++ + F GH + C++F+P
Sbjct: 16 KGHRDAVTCVDFSINT-KQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT 250
L+A+GS D T ++W E R H+A + S+ F + G +T S D TV VW
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310
+ + L H + A F+ D LI++ S DKT KLWD ++ +CV + H +
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370
F +G IA A D T +++ T + + + H ++ +SF+P GN+L+T SSD T +
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
Query: 371 IWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
I D G+ L L GH + AF+ G +G D +W+
Sbjct: 255 ILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 139 bits (351), Expect = 4e-33
Identities = 70/241 (29%), Positives = 126/241 (52%)
Query: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232
F+GH + C+ F+ + +A+GSMD+ +W ++ Y GH + ++F+ SG
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
+ +GS D TV +W + + + H A + S F D +T S DKT K+W
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
K + +L+ H + + + F G+LI +AS D T +++ ++R+C+ H G ++ +
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412
F+P G + D T ++WD +T + LQ + H+ + +F+ GN +IT S D+T +
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
Query: 413 I 413
I
Sbjct: 255 I 255
Score = 120 bits (302), Expect = 2e-27
Identities = 73/284 (25%), Positives = 123/284 (43%), Gaps = 1/284 (0%)
Query: 89 KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGD 148
K H +T V + + +GS D +W GH++ V + F +P G
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF-SPSGH 74
Query: 149 KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN 208
+A+GS DKT ++W FR HTA + + F T S D T K+W
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 209 GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSAS 268
+ +++L H + F+ G I++ S D TV +WD + V+ H ++
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 269 FNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTAR 328
F+ + I MD T K+WD + + H + F +G + TAS+D T +
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
Query: 329 IFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
I + + L GH+G + ++F+ G + +G SD+ +W
Sbjct: 255 ILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 117 bits (292), Expect = 3e-26
Identities = 69/238 (28%), Positives = 108/238 (45%), Gaps = 1/238 (0%)
Query: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
+T V + SG +GS D+T ++W E H V ++ F + G T S
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD-GQSFVTAS 122
Query: 155 FDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYT 214
DKT K+W+ K + H + C F+P L+ + S D T KLWD + E V++
Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
Query: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274
H + + F+ SG I D+TV VWD T R + H A ++ SF+ +
Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242
Query: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA 332
++T S D T K+ D G+ + TL GH F TG+ A+ +D ++ +
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
Score = 116 bits (291), Expect = 3e-26
Identities = 65/202 (32%), Positives = 102/202 (50%), Gaps = 1/202 (0%)
Query: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146
V +AH + +V G F+T S D+T K+W T + L +L H N V F +P
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF-SPD 156
Query: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
G I + S DKT KLW + +C H++ H + + F+P T +A MD T K+WD+
Sbjct: 157 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
Query: 207 QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266
+ + + HSA + LSF+ SG+ +IT S D T+ + D GR + L GH ++
Sbjct: 217 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 276
Query: 267 ASFNWDCSLILTGSMDKTCKLW 288
+F+ +G D+ +W
Sbjct: 277 VAFSRTGEYFASGGSDEQVMVW 298
Score = 96.7 bits (239), Expect = 4e-20
Identities = 59/198 (29%), Positives = 98/198 (49%), Gaps = 12/198 (6%)
Query: 52 EPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGS 111
+ +TAS + VK+ Q+ +LF L HI + + G ++ S
Sbjct: 116 QSFVTASDDKTVKVWATHRQK----------FLFS-LSQHINWVRCAKFSPDGRLIVSAS 164
Query: 112 YDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYH 171
D+T KLWD +S E +++ H V + F+ P G IA D T K+W V T +
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH-PSGTCIAAAGMDNTVKVWDVRTHRLLQ 223
Query: 172 TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSG 231
++ H+A + LSF+P + T S D+T K+ D+ G +YTL GH +++F+ +G
Sbjct: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283
Query: 232 DRIITGSFDHTVVVWDAD 249
+ +G D V+VW ++
Sbjct: 284 EYFASGGSDEQVMVWKSN 301
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 162 bits (409), Expect = 7e-40
Identities = 85/280 (30%), Positives = 140/280 (50%), Gaps = 9/280 (3%)
Query: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTL--------VATG 195
+P +AT + CKLWSV HT RGH + + F+P+ST+ +A+
Sbjct: 240 SPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASC 299
Query: 196 SMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN 255
+ D + KLW + + E V + GH+ + + ++ SG + T +D + +WD + ++
Sbjct: 300 AADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEIL 359
Query: 256 ILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTG 315
GH + +F+ D SL TG +D ++WD G+C+ L GH EI F G
Sbjct: 360 HQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNG 419
Query: 316 KLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNP-QGNHLLTGSSDKTARIWDA 374
IAT S D T +++ R+C+ + H+ ++ + F P GN LLTG+ D TA+IW
Sbjct: 420 YHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTH 479
Query: 375 QTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
L+ L GH ++ + G ++ T S D T ++W
Sbjct: 480 PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 152 bits (384), Expect = 5e-37
Identities = 86/290 (29%), Positives = 141/290 (48%), Gaps = 8/290 (2%)
Query: 94 PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN-------NPY 146
P++ + + T + CKLW L+TL GH V AI F+ +P
Sbjct: 233 PISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPK 292
Query: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
+A+ + D + KLWS+++ + GHT + + ++P + T D + +LWD+
Sbjct: 293 DVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352
Query: 207 QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266
+ EE+ GHS + ++F+ G TG D VWD TGR + L GH EI
Sbjct: 353 EAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 412
Query: 267 ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFD-YTGKLIATASADG 325
+F+ + I TGS D TCK+WD +CV T+ H + + F+ G + T + D
Sbjct: 413 INFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDN 472
Query: 326 TARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQ 375
TA+I++ + L GHEG++ + + G + T S D+T ++W A+
Sbjct: 473 TAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
Score = 130 bits (326), Expect = 3e-30
Identities = 68/239 (28%), Positives = 116/239 (48%), Gaps = 9/239 (3%)
Query: 185 FNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD--------RIIT 236
F+P S ++AT KLW + + ++TLRGH+ + ++ F+ + +
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
Query: 237 GSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCV 296
+ D +V +W D+ V + GH ++ ++ + T D++ +LWD + +
Sbjct: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358
Query: 297 ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQ 356
GH + D F G L T D R++ T +CI LEGH EI I+F+P
Sbjct: 359 LHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPN 418
Query: 357 GNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN-YKGNIVITGSKDNTCRIW 414
G H+ TGS D T ++WD + +C+ + H + + F GN ++TG+ DNT +IW
Sbjct: 419 GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW 477
Score = 127 bits (318), Expect = 2e-29
Identities = 69/204 (33%), Positives = 105/204 (51%), Gaps = 2/204 (0%)
Query: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
++ H + + V + SG T YDR+ +LWD + EE+ EGH VY IAF+ G
Sbjct: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQD-G 377
Query: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
TG D ++W + TG+C GH EI ++F+P +ATGS D T K+WD++
Sbjct: 378 SLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLR 437
Query: 208 NGEEVYTLRGHSAEIISLSFN-TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266
VYT+ H + + F G+ ++TG++D+T +W + L GH ++
Sbjct: 438 QRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMG 497
Query: 267 ASFNWDCSLILTGSMDKTCKLWDA 290
+ D LI T S D+T KLW A
Sbjct: 498 LDISSDGQLIATCSYDRTFKLWMA 521
Score = 85.1 bits (209), Expect = 1e-16
Identities = 53/207 (25%), Positives = 87/207 (42%), Gaps = 50/207 (24%)
Query: 258 IGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCF------ 311
IG IS F+ + ++ T CKLW + + TL GH+ + F
Sbjct: 228 IGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTV 287
Query: 312 --DYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHL--------- 360
D +A+ +ADG+ +++S + + +A +EGH ++++ ++P G L
Sbjct: 288 SLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSW 347
Query: 361 ---------------------------------LTGSSDKTARIWDAQTGQCLQVLEGHT 387
TG D R+WD +TG+C+ LEGH
Sbjct: 348 RLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHL 407
Query: 388 DEIFSCAFNYKGNIVITGSKDNTCRIW 414
EI+ F+ G + TGS DNTC++W
Sbjct: 408 KEIYGINFSPNGYHIATGSGDNTCKVW 434
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 159 bits (403), Expect = 3e-39
Identities = 86/285 (30%), Positives = 147/285 (51%), Gaps = 1/285 (0%)
Query: 131 EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST 190
+GH+ + ++ + P G ++AT S+D LW+ + + + GH + + F+P
Sbjct: 15 KGHKAAITSLDLS-PNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT 250
L+A+ S D T +LW + + H+A + S+ F+ G + T S D ++ VW
Sbjct: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
Query: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310
R + L H + A F+ D LI++ S DKT K+WD TN +CV +
Sbjct: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD 193
Query: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370
F+ +G IA+A +D T +++ K + + H G ++ ISF+P GN+L+T SSD T +
Sbjct: 194 FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253
Query: 371 IWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
I D G+ + L+GHT +F+ +F+ G + +G D +WR
Sbjct: 254 ILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298
Score = 136 bits (343), Expect = 3e-32
Identities = 78/289 (26%), Positives = 136/289 (47%), Gaps = 1/289 (0%)
Query: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
L + K H +T++ L+ +G T S+D LW+ GH++VV ++ F+
Sbjct: 10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
Query: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
P+G+ +A+ S D+T +LW + + F+ HTA + + F+ +AT S D + K+
Sbjct: 70 -PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
Query: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263
W + +Y+L H+ + F+ G I++ S D T+ +WD + VN
Sbjct: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
Query: 264 ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASA 323
+ FN + I + D+T K+WD K + H + F +G + TAS+
Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASS 248
Query: 324 DGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
DGT +I + I L+GH G + +SF+ G +G +D +W
Sbjct: 249 DGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 135 bits (339), Expect = 9e-32
Identities = 71/241 (29%), Positives = 117/241 (48%)
Query: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232
F+GH A I L +P +AT S DT LW+ + Y GH + S+ F+ G+
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
+ + S D TV +W D K + H A + S F+ D + T S DK+ K+W
Sbjct: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
Query: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
+ + +L H + + F G+LI + S D T +I+ ++C+ G + +
Sbjct: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD 193
Query: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412
FNP G + + SD+T ++WD + + LQ + H+ + +F+ GN +IT S D T +
Sbjct: 194 FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253
Query: 413 I 413
I
Sbjct: 254 I 254
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 152 bits (385), Expect = 4e-37
Identities = 98/332 (29%), Positives = 156/332 (46%), Gaps = 27/332 (8%)
Query: 98 VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDK 157
++L+ G +TGS D T +LW TA G+ L+GH + V F + T S D
Sbjct: 21 LSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV---TFCQLEDEAAFTCSADC 77
Query: 158 TCKLWSVETGKCYHTFRGHTAEI-VCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
T + W V TG+C +RGHT+ + L N Q + + S D TA++W + G+ R
Sbjct: 78 TIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ---LFSSSYDRTARVWSVDKGQMSREFR 134
Query: 217 GHSAEIISLSFN--------------TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCA 262
GH +++L+++ +G ++TGS D T VW +G L GH
Sbjct: 135 GHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTG 194
Query: 263 EISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATAS 322
+ + TGS D T + WD +G+ + H ++ C + +L+ + S
Sbjct: 195 AVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI--CLELVNRLVYSGS 252
Query: 323 ADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
AD T + + A T +C+ H +S + ++ L TGS D AR +DAQ+G+ +V
Sbjct: 253 ADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFDAQSGELRRV 310
Query: 383 LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
GHT I +C G ++ T S D R+W
Sbjct: 311 FRGHT-FIINC-IQVHGQVLYTASHDGALRLW 340
Score = 117 bits (292), Expect = 3e-26
Identities = 77/291 (26%), Positives = 124/291 (42%), Gaps = 35/291 (12%)
Query: 124 GEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCL 183
G L HR + ++ + P G ++ TGS D T +LWS G+C +GH + +
Sbjct: 5 GSALRVCADHRGGINWLSLS-PDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFC 63
Query: 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTV 243
++ T S D T + WD+ G+ + RGH++ + + + +++ + S+D T
Sbjct: 64 QLEDEAAF--TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRIL--VANNQLFSSSYDRTA 119
Query: 244 VVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHD 303
VW D G+ GH +C L L S WD + C
Sbjct: 120 RVWSVDKGQMSREFRGHR----------NCVLTLAYSAP-----WDLPSTPCAEEAAA-- 162
Query: 304 DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTG 363
G L+ T S DGTA+++ A+ C L GH G + + + G+ TG
Sbjct: 163 -----------GGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTG 211
Query: 364 SSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
S+D T R WD +G+ L+V H + +V +GS D T + W
Sbjct: 212 STDATIRAWDILSGEQLRVFREHRGSVI--CLELVNRLVYSGSADRTVKCW 260
Score = 97.8 bits (242), Expect = 2e-20
Identities = 60/187 (32%), Positives = 86/187 (45%), Gaps = 7/187 (3%)
Query: 103 SGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162
+G +TGS D T K+W ASG TL GH V + + P G TGS D T + W
Sbjct: 162 AGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTP-GHTAFTGSTDATIRAW 220
Query: 163 SVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEI 222
+ +G+ FR H ++CL + LV +GS D T K W GE V T H +
Sbjct: 221 DILSGEQLRVFREHRGSVICLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNV 278
Query: 223 ISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMD 282
+L ++ + TGS D +DA +G + GH I+ + ++ T S D
Sbjct: 279 SALKYHAG--TLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHG--QVLYTASHD 334
Query: 283 KTCKLWD 289
+LWD
Sbjct: 335 GALRLWD 341
Score = 85.9 bits (211), Expect = 6e-17
Identities = 50/179 (27%), Positives = 83/179 (46%), Gaps = 18/179 (10%)
Query: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310
G + + H I+ S + D +LTGS D T +LW +G+C A L GH+ + +
Sbjct: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV--TF 62
Query: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370
+ T SAD T R + T +C+ GH +++I N L + S D+TAR
Sbjct: 63 CQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTAR 120
Query: 371 IWDAQTGQCLQVLEGHTDEIFSCAFNYK--------------GNIVITGSKDNTCRIWR 415
+W GQ + GH + + + A++ G +++TGS D T ++W+
Sbjct: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQ 179
Score = 85.1 bits (209), Expect = 1e-16
Identities = 51/162 (31%), Positives = 76/162 (46%), Gaps = 7/162 (4%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
+ L+ H + + L+ G TGS D T + WD SGE+L HR V + N
Sbjct: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR 246
Query: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
+ +GS D+T K W +TG+C TF H + L ++ + + TGS D A+ +D
Sbjct: 247 L---VYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFD 301
Query: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Q+GE RGH+ I G + T S D + +WD
Sbjct: 302 AQSGELRRVFRGHT--FIINCIQVHGQVLYTASHDGALRLWD 341
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 151 bits (381), Expect = 1e-36
Identities = 80/260 (30%), Positives = 128/260 (49%)
Query: 156 DKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215
D +W ++ + F GH + C++F+P L+A+GS D T ++W E
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 216 RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSL 275
R H+A + S+ F + G +T S D TV VW + + L H + A F+ D L
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 276 ILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR 335
I++ S DKT KLWD ++ +CV + H + F +G IA A D T +++ T
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
Query: 336 KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAF 395
+ + + H ++ +SF+P GN+L+T SSD T +I D G+ L L GH + AF
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF 241
Query: 396 NYKGNIVITGSKDNTCRIWR 415
+ G +G D +W+
Sbjct: 242 SRTGEYFASGGSDEQVMVWK 261
Score = 120 bits (302), Expect = 2e-27
Identities = 62/217 (28%), Positives = 111/217 (51%)
Query: 197 MDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNI 256
MD+ +W ++ Y GH + ++F+ SG + +GS D TV +W + + +
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 257 LIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK 316
H A + S F D +T S DKT K+W K + +L+ H + + + F G+
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 317 LIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT 376
LI +AS D T +++ ++R+C+ H G ++ + F+P G + D T ++WD +T
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180
Query: 377 GQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRI 413
+ LQ + H+ + +F+ GN +IT S D+T +I
Sbjct: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
Score = 117 bits (292), Expect = 3e-26
Identities = 69/238 (28%), Positives = 108/238 (45%), Gaps = 1/238 (0%)
Query: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
+T V + SG +GS D+T ++W E H V ++ F + G T S
Sbjct: 26 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD-GQSFVTAS 84
Query: 155 FDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYT 214
DKT K+W+ K + H + C F+P L+ + S D T KLWD + E V++
Sbjct: 85 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 144
Query: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274
H + + F+ SG I D+TV VWD T R + H A ++ SF+ +
Sbjct: 145 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 204
Query: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA 332
++T S D T K+ D G+ + TL GH F TG+ A+ +D ++ +
Sbjct: 205 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 262
Score = 116 bits (291), Expect = 3e-26
Identities = 65/202 (32%), Positives = 102/202 (50%), Gaps = 1/202 (0%)
Query: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146
V +AH + +V G F+T S D+T K+W T + L +L H N V F +P
Sbjct: 60 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF-SPD 118
Query: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
G I + S DKT KLW + +C H++ H + + F+P T +A MD T K+WD+
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Query: 207 QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266
+ + + HSA + LSF+ SG+ +IT S D T+ + D GR + L GH ++
Sbjct: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 238
Query: 267 ASFNWDCSLILTGSMDKTCKLW 288
+F+ +G D+ +W
Sbjct: 239 VAFSRTGEYFASGGSDEQVMVW 260
Score = 96.7 bits (239), Expect = 4e-20
Identities = 59/198 (29%), Positives = 98/198 (49%), Gaps = 12/198 (6%)
Query: 52 EPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGS 111
+ +TAS + VK+ Q+ +LF L HI + + G ++ S
Sbjct: 78 QSFVTASDDKTVKVWATHRQK----------FLFS-LSQHINWVRCAKFSPDGRLIVSAS 126
Query: 112 YDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYH 171
D+T KLWD +S E +++ H V + F+ P G IA D T K+W V T +
Sbjct: 127 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH-PSGTCIAAAGMDNTVKVWDVRTHRLLQ 185
Query: 172 TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSG 231
++ H+A + LSF+P + T S D+T K+ D+ G +YTL GH +++F+ +G
Sbjct: 186 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 245
Query: 232 DRIITGSFDHTVVVWDAD 249
+ +G D V+VW ++
Sbjct: 246 EYFASGGSDEQVMVWKSN 263
Score = 64.7 bits (156), Expect = 1e-10
Identities = 34/134 (25%), Positives = 56/134 (41%)
Query: 281 MDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAK 340
MD +W TGH D + F +G L+A+ S D T RI+ +
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 341 LEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGN 400
H + + F G +T S DKT ++W + L L H + + F+ G
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 401 IVITGSKDNTCRIW 414
++++ S D T ++W
Sbjct: 121 LIVSASDDKTVKLW 134
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 150 bits (378), Expect = 3e-36
Identities = 105/377 (27%), Positives = 174/377 (46%), Gaps = 51/377 (13%)
Query: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
L+ H + +VA + +G +GS D T + WD ++ T +GHR+ V +I+++ P G
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS-PDG 168
Query: 148 DKIATGSFDKTCKLWSVETGKCY-HTFRGHTAEIVCLSF-----NPQSTLVATGSMDTTA 201
K+A+G + LW TGK T GH+ I LS+ NP+ VA+ S D +
Sbjct: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228
Query: 202 KLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC 261
++WD G L GH+ + L + G + + S D T+ VW A G L GH
Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
Query: 262 AEISSASFNWDCSL------------------------------------------ILTG 279
+++ + + D +L +++G
Sbjct: 288 HWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSG 347
Query: 280 SMDKTCKLWD-ATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCI 338
S D T LW A + K + +TGH I F +++A+AS D + +++ T K +
Sbjct: 348 SDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYL 407
Query: 339 AKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYK 398
A L GH + +I+++ L++GSSD T ++WD + + L GH DE+++ ++
Sbjct: 408 ASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPD 467
Query: 399 GNIVITGSKDNTCRIWR 415
G V +G KD RIWR
Sbjct: 468 GQRVASGGKDKCLRIWR 484
Score = 142 bits (358), Expect = 6e-34
Identities = 94/336 (27%), Positives = 160/336 (47%), Gaps = 51/336 (15%)
Query: 128 NTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNP 187
++LEGH V ++AF+ P G +A+GS D T + W + T + T +GH ++ +S++P
Sbjct: 108 SSLEGHSEAVISVAFS-PTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP 166
Query: 188 QSTLVATGSMDTTAKLWDIQNGEEV-YTLRGHSAEIISLSF-----NTSGDRIITGSFDH 241
+A+G + LWD G++V TL GHS I LS+ N + + S D
Sbjct: 167 DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226
Query: 242 TVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTG 301
+V +WD GR IL GH ++ + D L+ + S D+T K+W A +G TL G
Sbjct: 227 SVRIWDTTAGRCERILTGHTQSVTCLRWGGD-GLLYSASQDRTIKVWRAHDGVLCRTLQG 285
Query: 302 H-----------DDEILDSCF----------DYTGKL---------------------IA 319
H D + F D G L +
Sbjct: 286 HGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLV 345
Query: 320 TASADGTARIFS-AATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378
+ S D T ++S A +K + ++ GH+ I+++ F+P + + S DK+ ++WD +TG+
Sbjct: 346 SGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGK 405
Query: 379 CLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
L L GH ++ A++ ++++GS D+T ++W
Sbjct: 406 YLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
Score = 113 bits (282), Expect = 4e-25
Identities = 76/297 (25%), Positives = 135/297 (45%), Gaps = 52/297 (17%)
Query: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227
+C + GH+ ++ ++F+P +A+GS DTT + WD+ +T +GH ++S+S+
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
Query: 228 NTSGDRIITGSFDHTVVVWDADTGRKV-NILIGHCAEISSASF-----NWDCSLILTGSM 281
+ G ++ +G + +++WD TG++V L GH I+ S+ N +C + + S
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224
Query: 282 DKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK-LIATASADGTARIFSAATRKCIAK 340
D + ++WD T G+C LTGH + +C + G L+ +AS D T +++ A
Sbjct: 225 DGSVRIWDTTAGRCERILTGHTQSV--TCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRT 282
Query: 341 LEGH------------------EGEISKISFNPQG------------------------N 358
L+GH E ++ S NPQ
Sbjct: 283 LQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPE 342
Query: 359 HLLTGSSDKTARIWD-AQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
L++GS D T +W A+ + L + GH I F+ IV + S D + ++W
Sbjct: 343 RLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW 399
Score = 57.0 bits (136), Expect = 3e-08
Identities = 25/82 (30%), Positives = 42/82 (51%)
Query: 333 ATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFS 392
A +C + LEGH + ++F+P G +L +GS D T R WD T +GH + S
Sbjct: 102 AVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLS 161
Query: 393 CAFNYKGNIVITGSKDNTCRIW 414
+++ G + +G K+ +W
Sbjct: 162 ISWSPDGRKLASGCKNGQILLW 183
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 145 bits (367), Expect = 5e-35
Identities = 88/305 (28%), Positives = 148/305 (48%), Gaps = 12/305 (3%)
Query: 120 DTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHT-A 178
D S L GH + V F K+ +GS+D T KLW G F A
Sbjct: 88 DPLSKIPFKILSGHEHAVSTCHFCVD-DTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKA 146
Query: 179 EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITG- 237
+V S S+ V S D T + WD++ G+ ++ +R + I+S F+ G +++G
Sbjct: 147 PVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGF 205
Query: 238 SFDHTVVVWDADTGRKVNILIGH-CAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCV 296
DH + + DA+ V+++ H I+S F+ D + + S+D+ K+WD T+ +
Sbjct: 206 DVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATL 265
Query: 297 ATLT-GHDDEILDSCFDYTGKLIATASADGTARIFSAATRK------CIAKLEGHEGEIS 349
T+T H + I + CF ++G + T+S D +I++ T + C+ ++GHEG +S
Sbjct: 266 LTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVS 325
Query: 350 KISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDN 409
F + L++G D+T IWD G L+GH D + A + +++ SKD
Sbjct: 326 SCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDR 385
Query: 410 TCRIW 414
T R+W
Sbjct: 386 TMRLW 390
Score = 114 bits (285), Expect = 2e-25
Identities = 74/300 (24%), Positives = 125/300 (41%), Gaps = 10/300 (3%)
Query: 85 FKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNN 144
FK+L H ++ + ++GSYD T KLWD G + E
Sbjct: 95 FKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSIT 154
Query: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATG-SMDTTAKL 203
++ S+DKT + W +ETGK R T + C F+P V +G +D +
Sbjct: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKYVVSGFDVDHGICI 213
Query: 204 WDIQNGEEVYTLRGH-SAEIISLSFNTSGDRIITGSFDHTVVVWDADT-GRKVNILIGHC 261
D +N V ++ H + I S F+ R+ + S D + +WD + + I H
Sbjct: 214 MDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHS 273
Query: 262 AEISSASFNWDCSLILTGSMDKTCKLWDATNGK------CVATLTGHDDEILDSCFDYTG 315
IS+ F + + T S DK K+W+ G+ CV + GH+ + F
Sbjct: 274 NAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS 333
Query: 316 KLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQ 375
+ + D T I+ A L+GH + ++ + +L+ S D+T R+W+ +
Sbjct: 334 SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
Score = 79.3 bits (194), Expect = 6e-15
Identities = 44/175 (25%), Positives = 83/175 (47%), Gaps = 8/175 (4%)
Query: 91 HILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTL-EGHRNVVYAIAFNNPYGDK 149
H +T+ + + S DR K+WD S L T+ + H N + F G
Sbjct: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFS-GHF 287
Query: 150 IATGSFDKTCKLWSVETGK------CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
+ T S+DK K+W+V TG+ C +GH + F S+ + +G D T +
Sbjct: 288 LCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAI 347
Query: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI 258
WD+ G +L+GH+ ++ ++ + + I++ S D T+ +W+ + ++ ++I
Sbjct: 348 WDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVI 402
Score = 63.5 bits (153), Expect = 3e-10
Identities = 35/135 (25%), Positives = 64/135 (47%), Gaps = 7/135 (5%)
Query: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELN------TLEGHRNVV 137
L + KAH ++N SG T S+D+ K+W+ +GE N ++GH V
Sbjct: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV 324
Query: 138 YAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197
+ F + +G FD+T +W V G + +GH ++ ++ + + + S
Sbjct: 325 SSCHFARD-SSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASK 383
Query: 198 DTTAKLWDIQNGEEV 212
D T +LW+I+ +E+
Sbjct: 384 DRTMRLWNIEEIDEI 398
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 144 bits (364), Expect = 1e-34
Identities = 87/290 (30%), Positives = 149/290 (51%), Gaps = 27/290 (9%)
Query: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGS 196
VY + +++ KI +G D T K+W T +C GHT ++CL ++ + ++ TGS
Sbjct: 270 VYCLQYDD---QKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGS 324
Query: 197 MDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV-- 254
D+T ++WD+ GE + TL H ++ L FN ++T S D ++ VWD + +
Sbjct: 325 SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG--MMVTCSKDRSIAVWDMASPTDITL 382
Query: 255 -NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313
+L+GH A ++ F D I++ S D+T K+W+ + + V TL GH I +C Y
Sbjct: 383 RRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQY 438
Query: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
+L+ + S+D T R++ C+ LEGHE + I F+ +++G+ D ++WD
Sbjct: 439 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWD 496
Query: 374 --------AQTGQ-CLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
A G CL+ L H+ +F F+ +++ S D+T IW
Sbjct: 497 LVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIW 544
Score = 118 bits (295), Expect = 1e-26
Identities = 82/279 (29%), Positives = 134/279 (48%), Gaps = 27/279 (9%)
Query: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167
++G D T K+WD + E L GH V + ++ I TGS D T ++W V TG
Sbjct: 281 VSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV---IITGSSDSTVRVWDVNTG 337
Query: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR----GHSAEII 223
+ +T H ++ L FN + ++ T S D + +WD+ + ++ TLR GH A +
Sbjct: 338 EMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDI-TLRRVLVGHRAAVN 394
Query: 224 SLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDK 283
+ F+ I++ S D T+ VW+ T V L GH I A + L+++GS D
Sbjct: 395 VVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDN 450
Query: 284 TCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF---------SAAT 334
T +LWD G C+ L GH++ L C + K I + + DG +++ + A
Sbjct: 451 TIRLWDIECGACLRVLEGHEE--LVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAG 508
Query: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
C+ L H G + ++ F+ +++ S D T IWD
Sbjct: 509 TLCLRTLVEHSGRVFRLQFDE--FQIVSSSHDDTILIWD 545
Score = 94.7 bits (234), Expect = 1e-19
Identities = 64/205 (31%), Positives = 98/205 (47%), Gaps = 21/205 (10%)
Query: 100 LNKSGSCFITGSYDRTCKLWDTASGEEL---NTLEGHRNVVYAIAFNNPYGDKIATGSFD 156
L + +T S DR+ +WD AS ++ L GHR V + F++ Y I + S D
Sbjct: 353 LRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY---IVSASGD 409
Query: 157 KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
+T K+W+ T + T GH I CL + + LV +GS D T +LWDI+ G + L
Sbjct: 410 RTIKVWNTSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLE 467
Query: 217 GHSAEIISLSFNTSGDRIITGSFDHTVVVWD--------ADTGRK-VNILIGHCAEISSA 267
GH + + F+ RI++G++D + VWD A G + L+ H +
Sbjct: 468 GHEELVRCIRFDNK--RIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL 525
Query: 268 SFNWDCSLILTGSMDKTCKLWDATN 292
F D I++ S D T +WD N
Sbjct: 526 QF--DEFQIVSSSHDDTILIWDFLN 548
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 144 bits (364), Expect = 1e-34
Identities = 87/290 (30%), Positives = 149/290 (51%), Gaps = 27/290 (9%)
Query: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGS 196
VY + +++ KI +G D T K+W T +C GHT ++CL ++ + ++ TGS
Sbjct: 306 VYCLQYDD---QKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGS 360
Query: 197 MDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV-- 254
D+T ++WD+ GE + TL H ++ L FN ++T S D ++ VWD + +
Sbjct: 361 SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG--MMVTCSKDRSIAVWDMASPTDITL 418
Query: 255 -NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313
+L+GH A ++ F D I++ S D+T K+W+ + + V TL GH I +C Y
Sbjct: 419 RRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQY 474
Query: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
+L+ + S+D T R++ C+ LEGHE + I F+ +++G+ D ++WD
Sbjct: 475 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWD 532
Query: 374 --------AQTGQ-CLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
A G CL+ L H+ +F F+ +++ S D+T IW
Sbjct: 533 LVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIW 580
Score = 118 bits (295), Expect = 1e-26
Identities = 82/279 (29%), Positives = 134/279 (48%), Gaps = 27/279 (9%)
Query: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167
++G D T K+WD + E L GH V + ++ I TGS D T ++W V TG
Sbjct: 317 VSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV---IITGSSDSTVRVWDVNTG 373
Query: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR----GHSAEII 223
+ +T H ++ L FN + ++ T S D + +WD+ + ++ TLR GH A +
Sbjct: 374 EMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDI-TLRRVLVGHRAAVN 430
Query: 224 SLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDK 283
+ F+ I++ S D T+ VW+ T V L GH I A + L+++GS D
Sbjct: 431 VVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDN 486
Query: 284 TCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF---------SAAT 334
T +LWD G C+ L GH++ L C + K I + + DG +++ + A
Sbjct: 487 TIRLWDIECGACLRVLEGHEE--LVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAG 544
Query: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
C+ L H G + ++ F+ +++ S D T IWD
Sbjct: 545 TLCLRTLVEHSGRVFRLQFDE--FQIVSSSHDDTILIWD 581
Score = 94.7 bits (234), Expect = 1e-19
Identities = 64/205 (31%), Positives = 98/205 (47%), Gaps = 21/205 (10%)
Query: 100 LNKSGSCFITGSYDRTCKLWDTASGEEL---NTLEGHRNVVYAIAFNNPYGDKIATGSFD 156
L + +T S DR+ +WD AS ++ L GHR V + F++ Y I + S D
Sbjct: 389 LRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY---IVSASGD 445
Query: 157 KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
+T K+W+ T + T GH I CL + + LV +GS D T +LWDI+ G + L
Sbjct: 446 RTIKVWNTSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLE 503
Query: 217 GHSAEIISLSFNTSGDRIITGSFDHTVVVWD--------ADTGRK-VNILIGHCAEISSA 267
GH + + F+ RI++G++D + VWD A G + L+ H +
Sbjct: 504 GHEELVRCIRFDNK--RIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL 561
Query: 268 SFNWDCSLILTGSMDKTCKLWDATN 292
F D I++ S D T +WD N
Sbjct: 562 QF--DEFQIVSSSHDDTILIWDFLN 584
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 144 bits (363), Expect = 1e-34
Identities = 85/290 (29%), Positives = 149/290 (51%), Gaps = 27/290 (9%)
Query: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGS 196
VY + +++ +KI +G D + K+W + +C GHT ++CL ++ + ++ TGS
Sbjct: 243 VYCLQYDD---EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGS 297
Query: 197 MDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV-- 254
D+T ++WD+ GE + TL H+ ++ L F S ++T S D ++ VWD + +
Sbjct: 298 SDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITL 355
Query: 255 -NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313
+L+GH A ++ F D I++ S D+T K+W + + V TL GH I +C Y
Sbjct: 356 RRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQY 411
Query: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
+L+ + S+D T R++ C+ LEGHE + I F+ +++G+ D ++WD
Sbjct: 412 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWD 469
Query: 374 AQTG---------QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Q CL+ L H+ +F F+ +I+ S D+T IW
Sbjct: 470 LQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIW 517
Score = 123 bits (308), Expect = 3e-28
Identities = 84/279 (30%), Positives = 135/279 (48%), Gaps = 27/279 (9%)
Query: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167
I+G D + K+WD S E L L GH V + ++ I TGS D T ++W V TG
Sbjct: 254 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERV---IVTGSSDSTVRVWDVNTG 310
Query: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR----GHSAEII 223
+ +T H ++ L F+ + L+ T S D + +WD+ + ++ TLR GH A +
Sbjct: 311 EVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDI-TLRRVLVGHRAAVN 367
Query: 224 SLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDK 283
+ F+ I++ S D T+ VW T V L GH I A + L+++GS D
Sbjct: 368 VVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDN 423
Query: 284 TCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF---------SAAT 334
T +LWD G C+ L GH++ L C + K I + + DG +++ + A+
Sbjct: 424 TIRLWDIECGACLRVLEGHEE--LVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPAS 481
Query: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
C+ L H G + ++ F+ +++ S D T IWD
Sbjct: 482 TLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTILIWD 518
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 144 bits (363), Expect = 1e-34
Identities = 85/290 (29%), Positives = 149/290 (51%), Gaps = 27/290 (9%)
Query: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGS 196
VY + +++ +KI +G D + K+W + +C GHT ++CL ++ + ++ TGS
Sbjct: 209 VYCLQYDD---EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGS 263
Query: 197 MDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV-- 254
D+T ++WD+ GE + TL H+ ++ L F S ++T S D ++ VWD + +
Sbjct: 264 SDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITL 321
Query: 255 -NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313
+L+GH A ++ F D I++ S D+T K+W + + V TL GH I +C Y
Sbjct: 322 RRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQY 377
Query: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
+L+ + S+D T R++ C+ LEGHE + I F+ +++G+ D ++WD
Sbjct: 378 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWD 435
Query: 374 AQTG---------QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Q CL+ L H+ +F F+ +I+ S D+T IW
Sbjct: 436 LQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIW 483
Score = 123 bits (308), Expect = 3e-28
Identities = 84/279 (30%), Positives = 135/279 (48%), Gaps = 27/279 (9%)
Query: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167
I+G D + K+WD S E L L GH V + ++ I TGS D T ++W V TG
Sbjct: 220 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERV---IVTGSSDSTVRVWDVNTG 276
Query: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR----GHSAEII 223
+ +T H ++ L F+ + L+ T S D + +WD+ + ++ TLR GH A +
Sbjct: 277 EVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDI-TLRRVLVGHRAAVN 333
Query: 224 SLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDK 283
+ F+ I++ S D T+ VW T V L GH I A + L+++GS D
Sbjct: 334 VVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDN 389
Query: 284 TCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF---------SAAT 334
T +LWD G C+ L GH++ L C + K I + + DG +++ + A+
Sbjct: 390 TIRLWDIECGACLRVLEGHEE--LVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPAS 447
Query: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
C+ L H G + ++ F+ +++ S D T IWD
Sbjct: 448 TLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTILIWD 484
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 144 bits (363), Expect = 1e-34
Identities = 85/290 (29%), Positives = 149/290 (51%), Gaps = 27/290 (9%)
Query: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGS 196
VY + +++ +KI +G D + K+W + +C GHT ++CL ++ + ++ TGS
Sbjct: 230 VYCLQYDD---EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGS 284
Query: 197 MDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV-- 254
D+T ++WD+ GE + TL H+ ++ L F S ++T S D ++ VWD + +
Sbjct: 285 SDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITL 342
Query: 255 -NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313
+L+GH A ++ F D I++ S D+T K+W + + V TL GH I +C Y
Sbjct: 343 RRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQY 398
Query: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
+L+ + S+D T R++ C+ LEGHE + I F+ +++G+ D ++WD
Sbjct: 399 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWD 456
Query: 374 AQTG---------QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Q CL+ L H+ +F F+ +I+ S D+T IW
Sbjct: 457 LQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIW 504
Score = 123 bits (308), Expect = 3e-28
Identities = 84/279 (30%), Positives = 135/279 (48%), Gaps = 27/279 (9%)
Query: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167
I+G D + K+WD S E L L GH V + ++ I TGS D T ++W V TG
Sbjct: 241 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERV---IVTGSSDSTVRVWDVNTG 297
Query: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR----GHSAEII 223
+ +T H ++ L F+ + L+ T S D + +WD+ + ++ TLR GH A +
Sbjct: 298 EVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDI-TLRRVLVGHRAAVN 354
Query: 224 SLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDK 283
+ F+ I++ S D T+ VW T V L GH I A + L+++GS D
Sbjct: 355 VVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDN 410
Query: 284 TCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF---------SAAT 334
T +LWD G C+ L GH++ L C + K I + + DG +++ + A+
Sbjct: 411 TIRLWDIECGACLRVLEGHEE--LVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPAS 468
Query: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
C+ L H G + ++ F+ +++ S D T IWD
Sbjct: 469 TLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTILIWD 505
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 142 bits (359), Expect = 4e-34
Identities = 83/283 (29%), Positives = 145/283 (51%), Gaps = 12/283 (4%)
Query: 103 SGSCFITGSYDRTCKLWDTASG-EELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKL 161
+GS + +DR LW+ + TL+GH V + +N G + + S DKT +
Sbjct: 77 NGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD-GSMLFSASTDKTVAV 135
Query: 162 WSVETGKCYHTFRGHTAEI-VCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSA 220
W ETG+ +GHT+ + C LV TGS D T KLWDI+ + T + ++
Sbjct: 136 WDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTY 194
Query: 221 EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGS 280
++++++FN + D+II+G D+ + VWD + + GH ++ S + + S +L+ +
Sbjct: 195 QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNA 254
Query: 281 MDKTCKLWD----ATNGKCVATLTGH----DDEILDSCFDYTGKLIATASADGTARIFSA 332
MD T ++WD A +CV G+ + +L + G IA SAD ++
Sbjct: 255 MDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDT 314
Query: 333 ATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQ 375
+R+ + KL GH G I++++F+P +++ SSDK + + Q
Sbjct: 315 TSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
Score = 139 bits (350), Expect = 5e-33
Identities = 83/290 (28%), Positives = 142/290 (48%), Gaps = 14/290 (4%)
Query: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKC--YHTFRGHTAEIVCLSFNP 187
L GH VY F+ P G +A+ FD+ LW+V G C Y T +GH+ ++ L +N
Sbjct: 62 LSGHEGEVYCCKFH-PNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNT 119
Query: 188 QSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVVW 246
+++ + S D T +WD + GE V L+GH++ + S G +++ TGS D TV +W
Sbjct: 120 DGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLW 179
Query: 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI 306
D + + ++ + +FN I++G +D K+WD K T+ GH D +
Sbjct: 180 DIRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSV 238
Query: 307 LDSCFDYTGKLIATASADGTARIFS----AATRKCIAKLEGH----EGEISKISFNPQGN 358
G + + + D T R++ A +C+ +G+ E + + S++P G+
Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGS 298
Query: 359 HLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKD 408
+ GS+D+ +WD + + L L GH I AF+ I+I+ S D
Sbjct: 299 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
Score = 127 bits (320), Expect = 1e-29
Identities = 76/248 (30%), Positives = 125/248 (50%), Gaps = 9/248 (3%)
Query: 85 FKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNN 144
+ LK H + + N GS + S D+T +WD+ +GE + L+GH + V +
Sbjct: 102 YATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR 161
Query: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204
+ TGS D T KLW + TF+ +T +++ ++FN S + +G +D K+W
Sbjct: 162 RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
Query: 205 DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD----ADTGRKVNILIG- 259
D++ + YT+RGH+ + LS ++ G +++ + D+TV VWD A R V I G
Sbjct: 221 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGN 280
Query: 260 -HCAEISSASFNW--DCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK 316
H E + +W D S I GS D+ +WD T+ + + L GH I + F
Sbjct: 281 VHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEP 340
Query: 317 LIATASAD 324
+I +AS+D
Sbjct: 341 IIISASSD 348
Score = 104 bits (260), Expect = 1e-22
Identities = 52/209 (24%), Positives = 103/209 (49%), Gaps = 11/209 (5%)
Query: 212 VYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW----DADTGRKVNILIGHCAEISSA 267
+ L GH E+ F+ +G + + FD +++W D D L GH +
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDN---YATLKGHSGAVMEL 115
Query: 268 SFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTG--KLIATASADG 325
+N D S++ + S DKT +WD+ G+ V L GH ++SC+ +L+ T S DG
Sbjct: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTS-FVNSCYPARRGPQLVCTGSDDG 174
Query: 326 TARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEG 385
T +++ + I + + ++ ++FN + +++G D ++WD + + + G
Sbjct: 175 TVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRG 233
Query: 386 HTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
H D + + + +G+ +++ + DNT R+W
Sbjct: 234 HADSVTGLSLSSEGSYLLSNAMDNTVRVW 262
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 140 bits (352), Expect = 3e-33
Identities = 80/270 (29%), Positives = 134/270 (49%), Gaps = 1/270 (0%)
Query: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204
P+ D + + D+ K+ + T GHT + F+P +AT S DTT KLW
Sbjct: 362 PHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLW 421
Query: 205 DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEI 264
D+ G+ + T GHS + S ++++ G+ + + S D T +WD ++ R L GH +
Sbjct: 422 DLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSV 481
Query: 265 SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASAD 324
+S F + +LT S DKT +WDA G C +L GH I D+ FD G +IA+ A
Sbjct: 482 NSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDAC 541
Query: 325 GTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLE 384
G +++ I ++ ++++F+ G L S + + D ++G+ + L
Sbjct: 542 GVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGE-IHKLM 600
Query: 385 GHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
GH +E + F++ G I+ +G D T R W
Sbjct: 601 GHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 139 bits (349), Expect = 6e-33
Identities = 88/291 (30%), Positives = 141/291 (48%), Gaps = 2/291 (0%)
Query: 82 FYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIA 141
+ L + + H LP++ V++ ++ DR K+ L T GH + +
Sbjct: 342 YKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCC 401
Query: 142 FNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTA 201
F+ P GDK+AT S D T KLW + G C TF GH+ + +++ VA+ S+D T+
Sbjct: 402 FH-PSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTS 460
Query: 202 KLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC 261
K+WD+ + TL GH+ + S+ F + ++T S D T+ +WDA TG L GH
Sbjct: 461 KIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHM 520
Query: 262 AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATA 321
I+ A F+ +I + KLWD + ++ + FD +G+++A A
Sbjct: 521 HSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQA 580
Query: 322 SADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
S +G + + + I KL GHE E + F+ G L +G SD T R W
Sbjct: 581 SGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 89.0 bits (219), Expect = 7e-18
Identities = 49/160 (30%), Positives = 77/160 (48%)
Query: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314
NI H +S S ++++ D+ K+ + T GH D + D CF +
Sbjct: 346 NIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPS 405
Query: 315 GKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDA 374
G +AT+S D T +++ CI EGH + +++ GN + + S DKT++IWD
Sbjct: 406 GDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDV 465
Query: 375 QTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
+ +C L GHTD + S F N ++T S D T IW
Sbjct: 466 NSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIW 505
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 139 bits (350), Expect = 5e-33
Identities = 91/309 (29%), Positives = 143/309 (46%), Gaps = 28/309 (9%)
Query: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCY--------HTFRG------ 175
L GH + V+ A+N P D +A+GS D T ++W++ H R
Sbjct: 165 LRGHESEVFICAWN-PVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223
Query: 176 HTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII 235
++ L +N + TL+ATGS D A++W ++G TL H I +L +N G+ I+
Sbjct: 224 SNKDVTSLDWNSEGTLLATGSYDGFARIWT-KDGNLASTLGQHKGPIFALKWNKKGNFIL 282
Query: 236 TGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTG-SMDKTCKLWDATNGK 294
+ D T ++WDA TG H A + +W + S D + +
Sbjct: 283 SAGVDKTTIIWDAHTGEAKQQFPFHSAP--ALDVDWQSNNTFASCSTDMCIHVCKLGQDR 340
Query: 295 CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN 354
+ T GH +E+ +D TG L+A+ S D T +I+S C+ L+ H EI I ++
Sbjct: 341 PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWS 400
Query: 355 PQG--------NHLLTGSS-DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405
P G N +L +S D T R+WD G C+ L H + ++S AF+ G + +G
Sbjct: 401 PTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASG 460
Query: 406 SKDNTCRIW 414
S D IW
Sbjct: 461 SFDKCVHIW 469
Score = 105 bits (261), Expect = 1e-22
Identities = 64/252 (25%), Positives = 119/252 (47%), Gaps = 12/252 (4%)
Query: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
L L H P+ + NK G+ ++ D+T +WD +GE H + +
Sbjct: 258 LASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 317
Query: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
+ + A+ S D + + + TF+GHT E+ + ++P L+A+ S D T K+
Sbjct: 318 S--NNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKI 375
Query: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGD---------RIITGSFDHTVVVWDADTGRKV 254
W ++ V+ L+ H+ EI ++ ++ +G + + SFD TV +WD D G +
Sbjct: 376 WSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICI 435
Query: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314
+ L H + S +F+ D + +GS DK +W+ G V + G I + C++
Sbjct: 436 HTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAA 494
Query: 315 GKLIATASADGT 326
G + +++DG+
Sbjct: 495 GDKVGASASDGS 506
Score = 90.1 bits (222), Expect = 3e-18
Identities = 52/183 (28%), Positives = 89/183 (48%), Gaps = 14/183 (7%)
Query: 73 KLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEG 132
KLGQ+ K + H + + + +G+ + S D T K+W ++ L+
Sbjct: 335 KLGQDRP-----IKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQA 389
Query: 133 HRNVVYAIAF-------NNPYGD-KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLS 184
H +Y I + NNP + +A+ SFD T +LW V+ G C HT H + ++
Sbjct: 390 HNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVA 449
Query: 185 FNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVV 244
F+P +A+GS D +W+ Q G V++ RG + I + +N +GD++ + D +V
Sbjct: 450 FSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVC 508
Query: 245 VWD 247
V D
Sbjct: 509 VLD 511
Score = 70.5 bits (171), Expect = 3e-12
Identities = 57/217 (26%), Positives = 95/217 (43%), Gaps = 56/217 (25%)
Query: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW----DATNGKCVATLT------GH 302
K +L GH +E+ ++N L+ +GS D T ++W ++T+G L G
Sbjct: 161 KAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQ 220
Query: 303 D----DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358
D ++ ++ G L+AT S DG ARI++ + L H+G I + +N +GN
Sbjct: 221 DVPSNKDVTSLDWNSEGTLLATGSYDGFARIWT-KDGNLASTLGQHKGPIFALKWNKKGN 279
Query: 359 HLLTGSSDKTARIWDAQTGQ------------------------------CLQV------ 382
+L+ DKT IWDA TG+ C+ V
Sbjct: 280 FILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQD 339
Query: 383 -----LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
+GHT+E+ + ++ GN++ + S D T +IW
Sbjct: 340 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW 376
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 138 bits (348), Expect = 8e-33
Identities = 94/309 (30%), Positives = 144/309 (46%), Gaps = 28/309 (9%)
Query: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK--------CYHTFR--GHTA- 178
L GH + V+ A+N P D +A+GS D T ++W++ H R GH
Sbjct: 177 LRGHESEVFICAWN-PVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235
Query: 179 ---EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII 235
++ L +N TL+ATGS D A++W ++G TL H I +L +N G+ I+
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYIL 294
Query: 236 TGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTG-SMDKTCKLWDATNGK 294
+ D T ++WDA TG H A + +W + S D + +
Sbjct: 295 SAGVDKTTIIWDAHTGEAKQQFPFHSAP--ALDVDWQNNTTFASCSTDMCIHVCRLGCDR 352
Query: 295 CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN 354
V T GH +E+ +D +G L+A+ S D T +I+S CI L+ H EI I ++
Sbjct: 353 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 412
Query: 355 PQG--------NHLLTGSS-DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405
P G N +L +S D T R+WD + G C L H + ++S AF+ G + +G
Sbjct: 413 PTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASG 472
Query: 406 SKDNTCRIW 414
S D IW
Sbjct: 473 SFDKCVHIW 481
Score = 100 bits (250), Expect = 2e-21
Identities = 62/252 (24%), Positives = 118/252 (46%), Gaps = 12/252 (4%)
Query: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
L L H P+ + N+ G+ ++ D+T +WD +GE H + +
Sbjct: 270 LASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 329
Query: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
N A+ S D + + + TF+GHT E+ + ++P L+A+ S D T K+
Sbjct: 330 N--NTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 387
Query: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGD---------RIITGSFDHTVVVWDADTGRKV 254
W ++ ++ L+ H+ EI ++ ++ +G + + SFD TV +WD + G
Sbjct: 388 WSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT 447
Query: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314
+ L H + S +F+ D + +GS DK +W+ +G V + G I + C++
Sbjct: 448 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNAR 506
Query: 315 GKLIATASADGT 326
G + +++DG+
Sbjct: 507 GDKVGASASDGS 518
Score = 88.6 bits (218), Expect = 1e-17
Identities = 49/170 (28%), Positives = 83/170 (48%), Gaps = 9/170 (5%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI----- 140
K + H + + + SG + S D T K+W ++ L+ H +Y I
Sbjct: 355 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 414
Query: 141 --AFNNPYGD-KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197
A +NP + +A+ SFD T +LW +E G C HT H + ++F+P +A+GS
Sbjct: 415 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 474
Query: 198 DTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
D +W+ Q+G V++ RG + I + +N GD++ + D +V V D
Sbjct: 475 DKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLD 523
Score = 71.2 bits (173), Expect = 2e-12
Identities = 56/217 (25%), Positives = 95/217 (43%), Gaps = 56/217 (25%)
Query: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW---DATNGKCVATLT-------GH 302
K +L GH +E+ ++N L+ +GS D T ++W + +NG + GH
Sbjct: 173 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 232
Query: 303 D----DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358
D ++ ++ G L+AT S DG ARI++ + L H+G I + +N +GN
Sbjct: 233 DVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGN 291
Query: 359 HLLTGSSDKTARIWDAQTGQ------------------------------CLQV------ 382
++L+ DKT IWDA TG+ C+ V
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 351
Query: 383 -----LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
+GHT+E+ + ++ G ++ + S D T +IW
Sbjct: 352 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 138 bits (348), Expect = 8e-33
Identities = 94/309 (30%), Positives = 144/309 (46%), Gaps = 28/309 (9%)
Query: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK--------CYHTFR--GHTA- 178
L GH + V+ A+N P D +A+GS D T ++W++ H R GH
Sbjct: 177 LRGHESEVFICAWN-PVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235
Query: 179 ---EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII 235
++ L +N TL+ATGS D A++W ++G TL H I +L +N G+ I+
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYIL 294
Query: 236 TGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTG-SMDKTCKLWDATNGK 294
+ D T ++WDA TG H A + +W + S D + +
Sbjct: 295 SAGVDKTTIIWDAHTGEAKQQFPFHSAP--ALDVDWQNNTTFASCSTDMCIHVCRLGCDR 352
Query: 295 CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN 354
V T GH +E+ +D +G L+A+ S D T +I+S CI L+ H EI I ++
Sbjct: 353 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 412
Query: 355 PQG--------NHLLTGSS-DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405
P G N +L +S D T R+WD + G C L H + ++S AF+ G + +G
Sbjct: 413 PTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASG 472
Query: 406 SKDNTCRIW 414
S D IW
Sbjct: 473 SFDKCVHIW 481
Score = 100 bits (250), Expect = 2e-21
Identities = 62/252 (24%), Positives = 118/252 (46%), Gaps = 12/252 (4%)
Query: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
L L H P+ + N+ G+ ++ D+T +WD +GE H + +
Sbjct: 270 LASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 329
Query: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
N A+ S D + + + TF+GHT E+ + ++P L+A+ S D T K+
Sbjct: 330 N--NTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 387
Query: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGD---------RIITGSFDHTVVVWDADTGRKV 254
W ++ ++ L+ H+ EI ++ ++ +G + + SFD TV +WD + G
Sbjct: 388 WSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT 447
Query: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314
+ L H + S +F+ D + +GS DK +W+ +G V + G I + C++
Sbjct: 448 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNAR 506
Query: 315 GKLIATASADGT 326
G + +++DG+
Sbjct: 507 GDKVGASASDGS 518
Score = 88.6 bits (218), Expect = 1e-17
Identities = 49/170 (28%), Positives = 83/170 (48%), Gaps = 9/170 (5%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI----- 140
K + H + + + SG + S D T K+W ++ L+ H +Y I
Sbjct: 355 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 414
Query: 141 --AFNNPYGD-KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197
A +NP + +A+ SFD T +LW +E G C HT H + ++F+P +A+GS
Sbjct: 415 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 474
Query: 198 DTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
D +W+ Q+G V++ RG + I + +N GD++ + D +V V D
Sbjct: 475 DKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLD 523
Score = 71.2 bits (173), Expect = 2e-12
Identities = 56/217 (25%), Positives = 95/217 (43%), Gaps = 56/217 (25%)
Query: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW---DATNGKCVATLT-------GH 302
K +L GH +E+ ++N L+ +GS D T ++W + +NG + GH
Sbjct: 173 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 232
Query: 303 D----DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358
D ++ ++ G L+AT S DG ARI++ + L H+G I + +N +GN
Sbjct: 233 DVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGN 291
Query: 359 HLLTGSSDKTARIWDAQTGQ------------------------------CLQV------ 382
++L+ DKT IWDA TG+ C+ V
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 351
Query: 383 -----LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
+GHT+E+ + ++ G ++ + S D T +IW
Sbjct: 352 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 138 bits (348), Expect = 8e-33
Identities = 94/309 (30%), Positives = 144/309 (46%), Gaps = 28/309 (9%)
Query: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK--------CYHTFR--GHTA- 178
L GH + V+ A+N P D +A+GS D T ++W++ H R GH
Sbjct: 228 LRGHESEVFICAWN-PVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286
Query: 179 ---EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII 235
++ L +N TL+ATGS D A++W ++G TL H I +L +N G+ I+
Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYIL 345
Query: 236 TGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTG-SMDKTCKLWDATNGK 294
+ D T ++WDA TG H A + +W + S D + +
Sbjct: 346 SAGVDKTTIIWDAHTGEAKQQFPFHSAP--ALDVDWQNNTTFASCSTDMCIHVCRLGCDR 403
Query: 295 CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN 354
V T GH +E+ +D +G L+A+ S D T +I+S CI L+ H EI I ++
Sbjct: 404 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 463
Query: 355 PQG--------NHLLTGSS-DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405
P G N +L +S D T R+WD + G C L H + ++S AF+ G + +G
Sbjct: 464 PTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASG 523
Query: 406 SKDNTCRIW 414
S D IW
Sbjct: 524 SFDKCVHIW 532
Score = 100 bits (250), Expect = 2e-21
Identities = 62/252 (24%), Positives = 118/252 (46%), Gaps = 12/252 (4%)
Query: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
L L H P+ + N+ G+ ++ D+T +WD +GE H + +
Sbjct: 321 LASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380
Query: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
N A+ S D + + + TF+GHT E+ + ++P L+A+ S D T K+
Sbjct: 381 N--NTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 438
Query: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGD---------RIITGSFDHTVVVWDADTGRKV 254
W ++ ++ L+ H+ EI ++ ++ +G + + SFD TV +WD + G
Sbjct: 439 WSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT 498
Query: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314
+ L H + S +F+ D + +GS DK +W+ +G V + G I + C++
Sbjct: 499 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNAR 557
Query: 315 GKLIATASADGT 326
G + +++DG+
Sbjct: 558 GDKVGASASDGS 569
Score = 88.6 bits (218), Expect = 1e-17
Identities = 49/170 (28%), Positives = 83/170 (48%), Gaps = 9/170 (5%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI----- 140
K + H + + + SG + S D T K+W ++ L+ H +Y I
Sbjct: 406 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 465
Query: 141 --AFNNPYGD-KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197
A +NP + +A+ SFD T +LW +E G C HT H + ++F+P +A+GS
Sbjct: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 525
Query: 198 DTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
D +W+ Q+G V++ RG + I + +N GD++ + D +V V D
Sbjct: 526 DKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLD 574
Score = 71.2 bits (173), Expect = 2e-12
Identities = 56/217 (25%), Positives = 95/217 (43%), Gaps = 56/217 (25%)
Query: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW---DATNGKCVATLT-------GH 302
K +L GH +E+ ++N L+ +GS D T ++W + +NG + GH
Sbjct: 224 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 283
Query: 303 D----DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358
D ++ ++ G L+AT S DG ARI++ + L H+G I + +N +GN
Sbjct: 284 DVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGN 342
Query: 359 HLLTGSSDKTARIWDAQTGQ------------------------------CLQV------ 382
++L+ DKT IWDA TG+ C+ V
Sbjct: 343 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 402
Query: 383 -----LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
+GHT+E+ + ++ G ++ + S D T +IW
Sbjct: 403 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 138 bits (348), Expect = 8e-33
Identities = 94/309 (30%), Positives = 144/309 (46%), Gaps = 28/309 (9%)
Query: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK--------CYHTFR--GHTA- 178
L GH + V+ A+N P D +A+GS D T ++W++ H R GH
Sbjct: 228 LRGHESEVFICAWN-PVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286
Query: 179 ---EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII 235
++ L +N TL+ATGS D A++W ++G TL H I +L +N G+ I+
Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYIL 345
Query: 236 TGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTG-SMDKTCKLWDATNGK 294
+ D T ++WDA TG H A + +W + S D + +
Sbjct: 346 SAGVDKTTIIWDAHTGEAKQQFPFHSAP--ALDVDWQNNTTFASCSTDMCIHVCRLGCDR 403
Query: 295 CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN 354
V T GH +E+ +D +G L+A+ S D T +I+S CI L+ H EI I ++
Sbjct: 404 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 463
Query: 355 PQG--------NHLLTGSS-DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405
P G N +L +S D T R+WD + G C L H + ++S AF+ G + +G
Sbjct: 464 PTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASG 523
Query: 406 SKDNTCRIW 414
S D IW
Sbjct: 524 SFDKCVHIW 532
Score = 100 bits (250), Expect = 2e-21
Identities = 62/252 (24%), Positives = 118/252 (46%), Gaps = 12/252 (4%)
Query: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
L L H P+ + N+ G+ ++ D+T +WD +GE H + +
Sbjct: 321 LASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380
Query: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
N A+ S D + + + TF+GHT E+ + ++P L+A+ S D T K+
Sbjct: 381 N--NTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 438
Query: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGD---------RIITGSFDHTVVVWDADTGRKV 254
W ++ ++ L+ H+ EI ++ ++ +G + + SFD TV +WD + G
Sbjct: 439 WSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT 498
Query: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314
+ L H + S +F+ D + +GS DK +W+ +G V + G I + C++
Sbjct: 499 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNAR 557
Query: 315 GKLIATASADGT 326
G + +++DG+
Sbjct: 558 GDKVGASASDGS 569
Score = 88.6 bits (218), Expect = 1e-17
Identities = 49/170 (28%), Positives = 83/170 (48%), Gaps = 9/170 (5%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI----- 140
K + H + + + SG + S D T K+W ++ L+ H +Y I
Sbjct: 406 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 465
Query: 141 --AFNNPYGD-KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197
A +NP + +A+ SFD T +LW +E G C HT H + ++F+P +A+GS
Sbjct: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 525
Query: 198 DTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
D +W+ Q+G V++ RG + I + +N GD++ + D +V V D
Sbjct: 526 DKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLD 574
Score = 71.2 bits (173), Expect = 2e-12
Identities = 56/217 (25%), Positives = 95/217 (43%), Gaps = 56/217 (25%)
Query: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW---DATNGKCVATLT-------GH 302
K +L GH +E+ ++N L+ +GS D T ++W + +NG + GH
Sbjct: 224 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 283
Query: 303 D----DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358
D ++ ++ G L+AT S DG ARI++ + L H+G I + +N +GN
Sbjct: 284 DVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGN 342
Query: 359 HLLTGSSDKTARIWDAQTGQ------------------------------CLQV------ 382
++L+ DKT IWDA TG+ C+ V
Sbjct: 343 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 402
Query: 383 -----LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
+GHT+E+ + ++ G ++ + S D T +IW
Sbjct: 403 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 137 bits (344), Expect = 2e-32
Identities = 73/232 (31%), Positives = 117/232 (50%), Gaps = 4/232 (1%)
Query: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
K+L+ H P+ + S ++ S D + + WD S +GH V+ + + P
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDIS-P 394
Query: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Y A+GS D+T +LWS + + GH A++ C+ F+P S +ATGS D T +LW
Sbjct: 395 YSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWS 454
Query: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEIS 265
Q G V GH ++SL+F+ +G + + D + +WD +G L GH I+
Sbjct: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
Query: 266 SASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKL 317
S +F+ D LI + SMD + ++WD N C A G E++ YTG++
Sbjct: 515 SLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGV---YTGQM 563
Score = 117 bits (294), Expect = 1e-26
Identities = 60/229 (26%), Positives = 104/229 (45%)
Query: 174 RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDR 233
RGH + F S+ + + S D + + WD+ + +GH+ + L +
Sbjct: 339 RGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLY 398
Query: 234 IITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNG 293
+GS D T +W D + I GH A++ F+ + + + TGS DKT +LW A G
Sbjct: 399 FASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQG 458
Query: 294 KCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISF 353
V TGH +L F GK +A+A D +++ A+ +L GH I+ ++F
Sbjct: 459 NSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTF 518
Query: 354 NPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIV 402
+P + + S D + R+WD + C +G + E+ N++
Sbjct: 519 SPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVL 567
Score = 114 bits (286), Expect = 1e-25
Identities = 68/241 (28%), Positives = 108/241 (44%), Gaps = 1/241 (0%)
Query: 120 DTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAE 179
D +G E+ L GH VY+ F ++ S D + + W + + ++GH
Sbjct: 328 DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSC-SEDMSIRYWDLGSFTNTVLYQGHAYP 386
Query: 180 IVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSF 239
+ L +P S A+GS D TA+LW + GH A++ + F+ + + + TGS
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 446
Query: 240 DHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATL 299
D TV +W A G V + GH + S +F+ + + + D+ KLWD +G L
Sbjct: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
Query: 300 TGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNH 359
GH D I F LIA+AS D + R++ C A +G E+ + N
Sbjct: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNV 566
Query: 360 L 360
L
Sbjct: 567 L 567
Score = 109 bits (272), Expect = 5e-24
Identities = 65/278 (23%), Positives = 113/278 (40%), Gaps = 32/278 (11%)
Query: 169 CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN-------------------- 208
C++ F + +P S L+A G ++ KLW +++
Sbjct: 260 CFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACD 319
Query: 209 ------------GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNI 256
G E+ LRGH + S F +++ S D ++ WD + +
Sbjct: 320 ILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVL 379
Query: 257 LIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK 316
GH + + +GS D+T +LW + GH ++ F
Sbjct: 380 YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439
Query: 317 LIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT 376
+AT S D T R++SA + GH G + ++F+P G +L + D+ ++WD +
Sbjct: 440 YLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLAS 499
Query: 377 GQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
G + L GHTD I S F+ ++ + S DN+ R+W
Sbjct: 500 GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
Score = 97.8 bits (242), Expect = 2e-20
Identities = 51/166 (30%), Positives = 83/166 (50%), Gaps = 12/166 (7%)
Query: 83 YLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAF 142
Y ++ H+ + V + + + TGS D+T +LW G + GHR V ++AF
Sbjct: 417 YPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAF 476
Query: 143 NNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAK 202
+P G +A+ D+ KLW + +G Y RGHT I L+F+P S L+A+ SMD + +
Sbjct: 477 -SPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVR 535
Query: 203 LWDIQN-----------GEEVYTLRGHSAEIISLSFNTSGDRIITG 237
+WDI+N E V G + ++S+ F ++TG
Sbjct: 536 VWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTG 581
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,650,014
Number of Sequences: 37866
Number of extensions: 666737
Number of successful extensions: 7136
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 292
Number of HSP's successfully gapped in prelim test: 73
Number of HSP's that attempted gapping in prelim test: 1611
Number of HSP's gapped (non-prelim): 2092
length of query: 415
length of database: 18,247,518
effective HSP length: 105
effective length of query: 310
effective length of database: 14,271,588
effective search space: 4424192280
effective search space used: 4424192280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.