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Search of human proteins with 31542327
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
(577 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31542327 solute carrier family 22, member 16 [Homo sapiens] 1172 0.0
gi|24497490 solute carrier family 22 member 4 [Homo sapiens] 301 1e-81
gi|4507005 solute carrier family 22 member 5 [Homo sapiens] 301 1e-81
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa... 257 2e-68
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa... 253 3e-67
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap... 243 5e-64
gi|4507001 solute carrier family 22 member 2 [Homo sapiens] 240 2e-63
gi|11415038 solute carrier family 22 member 3 [Homo sapiens] 238 1e-62
gi|166064021 solute carrier family 22 (organic anion transporter... 231 1e-60
gi|166197673 solute carrier family 22, member 15 [Homo sapiens] 227 3e-59
gi|24497499 solute carrier family 22 member 8 [Homo sapiens] 226 4e-59
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa... 224 2e-58
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa... 223 4e-58
gi|238814326 solute carrier family 22, member 20 [Homo sapiens] 219 4e-57
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens] 216 6e-56
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa... 201 2e-51
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa... 192 5e-49
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa... 192 5e-49
gi|211059435 solute carrier family 22, member 24 [Homo sapiens] 191 1e-48
gi|148664184 solute carrier family 22, member 10 [Homo sapiens] 171 2e-42
gi|157426885 organic cation transporter like 4 [Homo sapiens] 170 3e-42
gi|42542386 solute carrier family 22 (organic anion/cation trans... 168 1e-41
gi|8923870 solute carrier family 22 member 11 [Homo sapiens] 165 9e-41
gi|153791484 putative UST1-like organic anion transporter [Homo ... 160 3e-39
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens] 132 7e-31
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1... 108 1e-23
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6... 104 2e-22
gi|213021148 SVOP-like isoform 1 [Homo sapiens] 104 2e-22
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ... 103 6e-22
gi|24308167 SV2 related protein [Homo sapiens] 101 2e-21
>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
Length = 577
Score = 1172 bits (3033), Expect = 0.0
Identities = 577/577 (100%), Positives = 577/577 (100%)
Query: 1 MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQ 60
MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQ
Sbjct: 1 MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQ 60
Query: 61 VVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSK 120
VVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSK
Sbjct: 61 VVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSK 120
Query: 121 KEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLG 180
KEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLG
Sbjct: 121 KEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLG 180
Query: 181 RRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRT 240
RRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRT
Sbjct: 181 RRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRT 240
Query: 241 WASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGR 300
WASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGR
Sbjct: 241 WASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGR 300
Query: 301 YEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTL 360
YEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTL
Sbjct: 301 YEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTL 360
Query: 361 TVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAY 420
TVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAY
Sbjct: 361 TVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAY 420
Query: 421 SLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGS 480
SLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGS
Sbjct: 421 SLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGS 480
Query: 481 GSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAA 540
GSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAA
Sbjct: 481 GSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAA 540
Query: 541 KLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE 577
KLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE
Sbjct: 541 KLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE 577
>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
Length = 551
Score = 301 bits (771), Expect = 1e-81
Identities = 186/569 (32%), Positives = 304/569 (53%), Gaps = 39/569 (6%)
Query: 4 RHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVF 63
R ++ + +G +G FQR+++F+ + I G + ++ VF+ TP H CR P
Sbjct: 2 RDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP-------- 53
Query: 64 HNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRE---NTSSLGYEY---- 116
D L S+ + + V ++L++G S CSR + N S+LG E
Sbjct: 54 ---------DAANLSSAWRNNSVPLRLRDGREVPHS-CSRYRLATIANFSALGLEPGRDV 103
Query: 117 -TGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYF 175
G ++ C+DG+ + Q+ + ST VT+WNLVC+ W L LF GVLLGS G
Sbjct: 104 DLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQL 163
Query: 176 SDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIG 235
SDR GR+ VL+AT + F F++ + F + M VV F+ E +G
Sbjct: 164 SDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILG 223
Query: 236 MKSRT-WASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCC---WVLPET 291
R ++++ + +FFAVG +L+ L Y +R W +M+L +TVP +LC W +PE+
Sbjct: 224 KSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDW---RMLLLALTVPGVLCVPLWWFIPES 280
Query: 292 PFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFY 351
P WL+S+ R+ EA+ I+ AK N + + ++ +P + QK + LF
Sbjct: 281 PRWLISQRRFREAEDIIQKAAKMNNIA------VPAVIFDSVEELNPLKQQKAFILDLFR 334
Query: 352 NWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDK 411
+I T+ L+W S+G+++ SL++ NL G+ YLN FL ++EIPAY + +
Sbjct: 335 TRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRT 394
Query: 412 VGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPT 471
+ RR ++A LF + ++P +Y L + M+GKF I +AF ++Y++TAELYPT
Sbjct: 395 LPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPT 454
Query: 472 IVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKR 531
+VR++AVG S R+ SI+AP+ V L + +P + +G++ +L G+LTL PE+LG
Sbjct: 455 LVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMT 514
Query: 532 LATTWEEAAKLESENESKSSKLLLTTNNS 560
L T E+ K++ K ++ + T +
Sbjct: 515 LPETLEQMQKVKWFRSGKKTRDSMETEEN 543
>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
Length = 557
Score = 301 bits (770), Expect = 1e-81
Identities = 188/564 (33%), Positives = 298/564 (52%), Gaps = 47/564 (8%)
Query: 4 RHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVF 63
R ++ + +G +G FQR+++F+ + I G L+SVF+ TP H CR P
Sbjct: 2 RDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVP-------- 53
Query: 64 HNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKR----ENTSSLGYEY--- 116
D L S+ + V ++L++G E+ R R N S+LG E
Sbjct: 54 ---------DAANLSSAWRNHTVPLRLRDGR--EVPHSCRRYRLATIANFSALGLEPGRD 102
Query: 117 --TGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGY 174
G ++ C+DG+ + Q+ + ST VT+WNLVC+ W A L LF GVLLGS G
Sbjct: 103 VDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQ 162
Query: 175 FSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFI 234
SDR GR+ VL+ T F F+ ++ F+ + M V FV E +
Sbjct: 163 LSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEIL 222
Query: 235 GMKSRT-WASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCC---WVLPE 290
G R ++++ + F+A G +++ L Y +R W +M+L +T+P +LC W +PE
Sbjct: 223 GKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDW---RMLLVALTMPGVLCVALWWFIPE 279
Query: 291 TPFWLLSEGRYEEAQKIVDIMAKWNR----ASSCKLSELLSLDLQGPVSNSPTEVQKHNL 346
+P WL+S+GR+EEA+ I+ AK N ++ SEL L S + Q HN+
Sbjct: 280 SPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDL--------SSKKQQSHNI 331
Query: 347 SYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVC 406
L W+I T+ ++W T S+G++ SL++ NL G+ ++N FL +VE+PAY
Sbjct: 332 LDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAW 391
Query: 407 IAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTA 466
+ + + RR +A +LF + ++P Y L V MVGKF + AAF ++Y+YTA
Sbjct: 392 LLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTA 451
Query: 467 ELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPE 526
ELYPT+VR++ VG S RL SIL+P+ V L + F+P + +G++ +L+ +LTL LPE
Sbjct: 452 ELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPE 511
Query: 527 TLGKRLATTWEEAAKLESENESKS 550
+ G L T ++ +++ K+
Sbjct: 512 SFGTPLPDTIDQMLRVKGMKHRKT 535
>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
sapiens]
Length = 546
Score = 257 bits (657), Expect = 2e-68
Identities = 168/539 (31%), Positives = 266/539 (49%), Gaps = 17/539 (3%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPG---NVSQVV 62
FE + + VG FG FQ + A + +H+L +F+ P H C PG N S
Sbjct: 3 FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQD 62
Query: 63 FHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKE 122
++ E G L S + Y L N + E R SR + E+ +
Sbjct: 63 VWLEAHLPREPDGTLSSCLRFAYPQA-LPNTTLGE-ERQSRGELEDEPAT---------- 110
Query: 123 FPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRR 182
PC G+ YD + + ST T+W+LVC++K L F GVL+G+V FGY SDR GRR
Sbjct: 111 VPCSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRR 170
Query: 183 VVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWA 242
+L S + G+A+A +V Y F R +G+ ++ +E++ ++ RT A
Sbjct: 171 RLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVA 230
Query: 243 SVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYE 302
V +F+ G +L+AL GYL+R W + ++ P IL W +PE+ WLL++G +
Sbjct: 231 GVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVK 290
Query: 303 EAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTV 362
EA + + A+ N C+ + S + V+ V++ + LF + +L
Sbjct: 291 EAHRYLLHCARLNGRPVCE--DSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCC 348
Query: 363 WLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSL 422
++WF + +Y SL+ LG N Y L G VE+P+ V +++ GRR A +L
Sbjct: 349 VVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTL 408
Query: 423 FCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGS 482
+ALA G +++ V A++GK AAF YL+T+ELYPT++R +G +
Sbjct: 409 LGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTA 468
Query: 483 MVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAK 541
+V RL LAP + L +W+ +P+L G +ALL+ L LPET +L T ++ +
Sbjct: 469 LVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER 527
>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
sapiens]
Length = 548
Score = 253 bits (647), Expect = 3e-67
Identities = 169/541 (31%), Positives = 266/541 (49%), Gaps = 19/541 (3%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPG---NVSQVV 62
FE + + VG FG FQ + A + +H+L +F+ P H C PG N S
Sbjct: 3 FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQD 62
Query: 63 FHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKE 122
++ E G L S + Y L N + E R SR + E+ +
Sbjct: 63 VWLEAHLPREPDGTLSSCLRFAYPQA-LPNTTLGE-ERQSRGELEDEPAT---------- 110
Query: 123 FPCVDGYIYDQNTWKSTAVT--QWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLG 180
PC G+ YD + + ST T QW+LVC++K L F GVL+G+V FGY SDR G
Sbjct: 111 VPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFG 170
Query: 181 RRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRT 240
RR +L S + G+A+A +V Y F R +G+ ++ +E++ ++ RT
Sbjct: 171 RRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRT 230
Query: 241 WASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGR 300
A V +F+ G +L+AL GYL+R W + ++ P IL W +PE+ WLL++G
Sbjct: 231 VAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGH 290
Query: 301 YEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTL 360
+EA + + A+ N C+ + S + V+ V++ + LF + +L
Sbjct: 291 VKEAHRYLLHCARLNGRPVCE--DSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISL 348
Query: 361 TVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAY 420
++WF + +Y SL+ LG N Y L G VE+P+ V +++ GRR A
Sbjct: 349 CCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAG 408
Query: 421 SLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGS 480
+L +ALA G +++ V A++GK AAF YL+T+ELYPT++R +G
Sbjct: 409 TLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGL 468
Query: 481 GSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAA 540
++V RL LAP + L +W+ +P+L G +ALL+ L LPET +L T ++
Sbjct: 469 TALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVE 528
Query: 541 K 541
+
Sbjct: 529 R 529
>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
sapiens]
Length = 554
Score = 243 bits (619), Expect = 5e-64
Identities = 177/566 (31%), Positives = 268/566 (47%), Gaps = 33/566 (5%)
Query: 7 EGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNH 66
+ I + VG G FQ+ + I + + + VF+G TP H C+ PG
Sbjct: 5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAE---LSQR 61
Query: 67 SNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRE-NTSSLG-----YEYTGSK 120
WS + + +Y L L +C R + + N S+L ++
Sbjct: 62 CGWS--------PAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNR 113
Query: 121 KEF---PCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSD 177
PC DG++YD T S+ VT++NLVC W L Q G L GS+ GYF+D
Sbjct: 114 SHLPLGPCQDGWVYD--TPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFAD 171
Query: 178 RLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMK 237
R GR++ L T + G+ AF+ +Y + + R +V+ G + G+ + EF+G
Sbjct: 172 RFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSG 231
Query: 238 SRTWASVHLHSFFAVGTLLVALTG--YLVRTWWLYQMILSTVTVPFILCCWVLPETPFWL 295
SR ++ F VG LVALTG Y + W Q+ +S T F+L W +PE+P WL
Sbjct: 232 SRRTVAIMYQMAFTVG--LVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWL 289
Query: 296 LSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSI 355
LS+ R EA KI+D +A+ N ++LSL+ TE + + LF +
Sbjct: 290 LSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLE------EDVTEKLSPSFADLFRTPRL 343
Query: 356 TKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRR 415
KRT + +WFT S+ + L+ GN YL+ +VEIP I +D+VGR
Sbjct: 344 RKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRI 403
Query: 416 TVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRS 475
+A S + AC V++ I + L ++ VG+ I A +I L AELYPT VR+
Sbjct: 404 YPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRN 463
Query: 476 LAVGSGSMVCRLASILAPFSV-DLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLAT 534
L V S +C + I+ PF V L +W +P + + LL+ +TL LPET G L
Sbjct: 464 LGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPE 523
Query: 535 TWEEAAKLESENESKSSKLLLTTNNS 560
T ++A L + + K + + L S
Sbjct: 524 TMKDAENLGRKAKPKENTIYLKVQTS 549
>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
Length = 555
Score = 240 bits (613), Expect = 2e-63
Identities = 160/564 (28%), Positives = 271/564 (48%), Gaps = 39/564 (6%)
Query: 7 EGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFH-- 64
+ + +H G F FQ+ ++F+ A + + Y+ VF+G TP H CR PG V+++
Sbjct: 6 DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPG-VAELSLRCG 64
Query: 65 ----NHSNWSLEDTGALLSSGQKDYVTVQLQNGEI-WELSR-------CSRNKRENTSSL 112
N+++ G + + Q + E+ W S S + + L
Sbjct: 65 WSPAEELNYTVPGPGPAGEASPR-----QCRRYEVDWNQSTFDCVDPLASLDTNRSRLPL 119
Query: 113 GYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTF 172
G PC DG++Y+ T S+ VT++NLVC W+ L Q G +GS++
Sbjct: 120 G----------PCRDGWVYE--TPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSI 167
Query: 173 GYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVME 232
GY +DR GR++ L T G+ A + Y + R +V+ ++G++ + E
Sbjct: 168 GYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITE 227
Query: 233 FIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETP 292
F+G + R + + VG L++A Y + W Q ++ F+L W +PE+P
Sbjct: 228 FVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESP 287
Query: 293 FWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYN 352
WL+S+ + EA +I+ +AK N S + L L+ + +P+ + L
Sbjct: 288 RWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLD------LVRT 341
Query: 353 WSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKV 412
I K T+ + WFT S+ + ++ G N YL+ F +VE PA + + +D++
Sbjct: 342 PQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRI 401
Query: 413 GRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTI 472
GRR A S + AC + IP L ++ + +G+ I A+ ++ L AELYPT
Sbjct: 402 GRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTF 461
Query: 473 VRSLAVGSGSMVCRLASILAPFSV-DLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKR 531
+R+L V S +C + I+ PF V L++IW+ +P + G + L++G L L LPET GK
Sbjct: 462 IRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKA 521
Query: 532 LATTWEEAAKLESENESKSSKLLL 555
L T EEA ++ ++K + L
Sbjct: 522 LPETIEEAENMQRPRKNKEKMIYL 545
>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
Length = 556
Score = 238 bits (606), Expect = 1e-62
Identities = 156/556 (28%), Positives = 264/556 (47%), Gaps = 23/556 (4%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTP-HHVCRPPGNVSQVVFH 64
F+ VG FGRFQR ++ + ++ ++ VF+G P H+ CR P S
Sbjct: 4 FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGP---SAAALA 60
Query: 65 NHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEY------TG 118
WS E+ + + + + L + + TS+L
Sbjct: 61 ERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNR 120
Query: 119 SKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDR 178
S PC G+ Y Q ST V++++LVC W+ L Q + G L G+ T GY +DR
Sbjct: 121 SAPLVPCRGGWRYAQA--HSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADR 178
Query: 179 LGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKS 238
GR V+ + + + G+ AFA ++ F+ RF + G + +V V E +G K
Sbjct: 179 YGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQ 238
Query: 239 RTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSE 298
R + + FF +G +++ Y + W Q+ ++ + F+L WV+PE+P WL++
Sbjct: 239 RRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITR 298
Query: 299 GRYEEAQKIVDIMAKWN-RASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITK 357
+ ++A +I+ +AK N + S SE+ D EV + L + K
Sbjct: 299 KKGDKALQILRRIAKCNGKYLSSNYSEITVTD---------EEVSNPSFLDLVRTPQMRK 349
Query: 358 RTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTV 417
TL + WFT ++ + + +GGN Y++ F+ GVVE+P + + ++++GRR
Sbjct: 350 CTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLP 409
Query: 418 LAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLA 477
A S + +AC V +P+ L A +G+ I AF ++YL +ELYPT +R+
Sbjct: 410 FAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFG 469
Query: 478 VGSGSMVCRLASILAPFSV-DLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTW 536
V S +C I+APF + L+++W+ +P + G +A + G L + LPET G L T
Sbjct: 470 VSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETV 529
Query: 537 EEAAKLESENESKSSK 552
++ KL S + K +
Sbjct: 530 DDVEKLGSPHSCKCGR 545
>gi|166064021 solute carrier family 22 (organic anion transporter),
member 13 [Homo sapiens]
Length = 551
Score = 231 bits (590), Expect = 1e-60
Identities = 162/534 (30%), Positives = 252/534 (47%), Gaps = 25/534 (4%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65
F + +G FGRFQ L + N ++ A VFM + H C V+ V H
Sbjct: 4 FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCA----VAWVKNHT 59
Query: 66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPC 125
+ LS+ ++ ++V L E R N S + PC
Sbjct: 60 FN----------LSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPC 109
Query: 126 VDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVL 185
G+ Y +N S ++NLVCDRK L Q +FM G+L+G++ FG DR+GR+ +
Sbjct: 110 DMGWEYPENRLPSLK-NEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATI 168
Query: 186 WATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVH 245
A L G+A AF + +MA RF +A +G + E++G RT A V
Sbjct: 169 LAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVL 228
Query: 246 LHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQ 305
F++G +++A Y R W L Q+ + + W LPE+ WLL+ GR +EA
Sbjct: 229 AQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAI 288
Query: 306 KIVDIMAKWNRAS-SCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWL 364
+++ A NR S +L L + GP N+ LF + + K TL ++
Sbjct: 289 QLIQKAASVNRRKLSPELMNQLVPEKTGPSGNALD---------LFRHPQLRKVTLIIFC 339
Query: 365 IWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFC 424
+WF SLG+Y SL + G + YL + G VE+PA M + GR+ +L
Sbjct: 340 VWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVL 399
Query: 425 SALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMV 484
L C +++ IP ++ + A+VGK A AAF + Y+Y+AEL+PTI+R +G +
Sbjct: 400 GGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIF 459
Query: 485 CRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEE 538
R+ IL P + L +P L G++ +++G+L LPET G+ L T ++
Sbjct: 460 SRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQD 513
>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
Length = 547
Score = 227 bits (578), Expect = 3e-59
Identities = 150/459 (32%), Positives = 238/459 (51%), Gaps = 29/459 (6%)
Query: 96 WELSRCSRNKRENTSSLGYEY-------TGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVC 148
W+L+ N+ S G + T + E + +++ +++ S A ++W L+
Sbjct: 50 WDLAELLPNQSHGNQSAGEDQAFGDWLLTANGSE---IHKHVHFSSSFTSIA-SEWFLIA 105
Query: 149 DRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTF 208
+R + F GV +G ++FG SDR GR+ V + LF IA F+ Y F
Sbjct: 106 NRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFF 165
Query: 209 MAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWW 268
RF + M+ G +V FV + E +G A FFAVG AL GY +R+W
Sbjct: 166 AVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWR 225
Query: 269 LYQMILSTV-TVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLS 327
++++ TV F+L ++ PE+P WL S+GR EA++ + ++AK NR C S
Sbjct: 226 TLAILVNLQGTVVFLLSLFI-PESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFS---- 280
Query: 328 LDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNE 387
L P + S E + LF + TL + IWF SL +Y +L++ +LGG+
Sbjct: 281 --LTHPANRSCRETG--SFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSI 336
Query: 388 YLNLFLLGVVEIPAYTFVCIAMDK--VGRRTVLAYSLFCSALACGVVMVIPQKHY--ILG 443
Y NL L G++EIP+Y +++ GR+ L+ L LAC +VM +P+K +
Sbjct: 337 YANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFA 396
Query: 444 VVTA----MVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLS 499
VV + ++GK I AAF ++Y+YT+ELYPT++R++ +G+ SM R+ I+APF L
Sbjct: 397 VVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLK 456
Query: 500 SIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEE 538
+ +P + G L SG+L+L LPETL L T+ +
Sbjct: 457 YVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSD 495
>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
Length = 542
Score = 226 bits (576), Expect = 4e-59
Identities = 164/569 (28%), Positives = 260/569 (45%), Gaps = 44/569 (7%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65
F I D VG G FQ + I ++ H L +F TP H CRPP N S
Sbjct: 3 FSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNAS------ 56
Query: 66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPC 125
TG + L G + RC R +SL + + + PC
Sbjct: 57 --------TGPWV-----------LPMGPNGKPERCLRFVHPPNASLPNDTQRAME--PC 95
Query: 126 VDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVL 185
+DG++Y N+ K + VT+W+LVC+ L + Q +FM G+L+G + G SDR GRR +L
Sbjct: 96 LDGWVY--NSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPIL 153
Query: 186 WATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVH 245
+ + G AAF+ + +M RF SG + + +E++ + R S
Sbjct: 154 TCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTA 213
Query: 246 LHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQ 305
L + G ++ Y + W Q+ +S F L W PE+ WL+ G+ +A
Sbjct: 214 LGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKAL 273
Query: 306 KIVDIMAKWN--RASSCKLS-ELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTV 362
KI+ +A +N + +LS E L L+LQ +S + K+ S LF + + T +
Sbjct: 274 KILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKA---KYTASDLFRIPMLRRMTFCL 330
Query: 363 WLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSL 422
L WF +YS ++ G N Y+ + G V++PA +++ +GR T A +L
Sbjct: 331 SLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAAL 390
Query: 423 FCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGS 482
+ A + +P + V A+ GK + ++F ++LYT+ELYPT++R +G +
Sbjct: 391 LLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSN 450
Query: 483 MVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEE---- 538
+ R+ S+++P + FIP + G ALL G L LPETL + L T E+
Sbjct: 451 LWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENW 510
Query: 539 -----AAKLESENESKSSKLLLTTNNSGL 562
K E E E S ++ L + GL
Sbjct: 511 SLRAKKPKQEPEVEKASQRIPLQPHGPGL 539
>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
sapiens]
Length = 550
Score = 224 bits (570), Expect = 2e-58
Identities = 160/571 (28%), Positives = 262/571 (45%), Gaps = 38/571 (6%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65
F + VG GRFQ++ + + H F P H CRPP + +
Sbjct: 3 FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN------ 56
Query: 66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPC 125
L +G + + + G+ R + + G E G+ PC
Sbjct: 57 -----------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPC 105
Query: 126 VDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVL 185
DG+IYD +T+ ST VT+W+LVC + L L Q L+M GVLLG++ FGY +DRLGRR VL
Sbjct: 106 TDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVL 165
Query: 186 WATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVH 245
+ G AAFA ++ + A R M +G + +E++ + +R
Sbjct: 166 ILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL 225
Query: 246 LHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQ 305
+ +++G L+A Y V W Q+++S F + W E+ W S GR +
Sbjct: 226 IGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTL 285
Query: 306 KIVDIMAKWN--RASSCKLS-ELLSLDLQ-----GPVSNSPTEVQK-HNLSYLFYNWSIT 356
+ + +A+ N R KLS E+L LQ G S E+ + L +LF
Sbjct: 286 RALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLF------ 339
Query: 357 KRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRT 416
L + ++WF S +Y ++ G + YL + G V++PA + ++ +GRR
Sbjct: 340 ---LCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRP 396
Query: 417 VLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSL 476
+L + + + VIPQ I+ A++GK + A+F I+LYT ELYPT++R
Sbjct: 397 AQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQT 456
Query: 477 AVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATT- 535
+G GS + R+ SI++P + ++ +P G + + + +T+ LPETLG+ L T
Sbjct: 457 GMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTV 516
Query: 536 --WEEAAKLESENESKSSKLLLTTNNSGLEK 564
E ++ + + K ++ S EK
Sbjct: 517 QDLESRKGKQTRQQQEHQKYMVPLQASAQEK 547
>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
sapiens]
Length = 563
Score = 223 bits (568), Expect = 4e-58
Identities = 155/542 (28%), Positives = 253/542 (46%), Gaps = 35/542 (6%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65
F + VG GRFQ++ + + H F P H CRPP + +
Sbjct: 3 FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN------ 56
Query: 66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPC 125
L +G + + + G+ R + + G E G+ PC
Sbjct: 57 -----------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPC 105
Query: 126 VDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVL 185
DG+IYD +T+ ST VT+W+LVC + L L Q L+M GVLLG++ FGY +DRLGRR VL
Sbjct: 106 TDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVL 165
Query: 186 WATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVH 245
+ G AAFA ++ + A R M +G + +E++ + +R
Sbjct: 166 ILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL 225
Query: 246 LHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQ 305
+ +++G L+A Y V W Q+++S F + W E+ W S GR +
Sbjct: 226 IGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTL 285
Query: 306 KIVDIMAKWN--RASSCKLS-ELLSLDLQ-----GPVSNSPTEVQK-HNLSYLFYNWSIT 356
+ + +A+ N R KLS E+L LQ G S E+ + L +LF
Sbjct: 286 RALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLF------ 339
Query: 357 KRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRT 416
L + ++WF S +Y ++ G + YL + G V++PA + ++ +GRR
Sbjct: 340 ---LCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRP 396
Query: 417 VLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSL 476
+L + + + VIPQ I+ A++GK + A+F I+LYT ELYPT++R
Sbjct: 397 AQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQT 456
Query: 477 AVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTW 536
+G GS + R+ SI++P + ++ +P G + + + +T+ LPETLG+ L T
Sbjct: 457 GMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTV 516
Query: 537 EE 538
++
Sbjct: 517 QD 518
>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
Length = 555
Score = 219 bits (559), Expect = 4e-57
Identities = 161/551 (29%), Positives = 256/551 (46%), Gaps = 29/551 (5%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGI----HYLASVFMGVTPHHVCRPPGNVSQV 61
F + D +G GRFQ A + CG+ ++L + V PHH CR P N
Sbjct: 3 FTDLLDALGSMGRFQ---LNHTALLLLPCGLLACHNFLQNFTAAVPPHH-CRGPAN---- 54
Query: 62 VFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKK 121
H+ S D+GA L + T+ L E R + S G+
Sbjct: 55 ----HTEASTNDSGAWLRA------TIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAAT 104
Query: 122 EFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGR 181
E C DG++Y+++ + ST V +W+LVC+ + L L Q ++M GVL+G+ FG +DRLG
Sbjct: 105 E-GCKDGWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGC 163
Query: 182 RVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW 241
+ L + + G A A+ + + RF + M SG ++ V+E++ + RT
Sbjct: 164 KGPLVWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTV 223
Query: 242 ASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRY 301
A + L F +G L++A YL+R W Q +S + F L W LPE+ WLL G+
Sbjct: 224 AGILLGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKS 283
Query: 302 EEAQKIVDIMAKWN---RASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKR 358
+ A + + +A N E++S +Q ++ T +++ LF +I K
Sbjct: 284 QLAVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCT---SNSILDLFRTPAIRKV 340
Query: 359 TLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVL 418
T + +IWF+ S+ +Y +++ G + YL L G++ PA M VGRR +
Sbjct: 341 TCCLMVIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATV 400
Query: 419 AYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAV 478
A L + L M +P+ IL A +GK + ++F +YL+T ELYPT +R + +
Sbjct: 401 ASFLILAGLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGM 460
Query: 479 GSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEE 538
G S+ RL + AP L +P + G A+L+G+ L ET L T
Sbjct: 461 GFASVHARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAA 520
Query: 539 AAKLESENESK 549
+ E SK
Sbjct: 521 MERRVKEGSSK 531
>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
Length = 553
Score = 216 bits (549), Expect = 6e-56
Identities = 171/577 (29%), Positives = 260/577 (45%), Gaps = 43/577 (7%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65
F + D VG GRFQ + + + F P H C P + N
Sbjct: 3 FSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAP------LLDN 56
Query: 66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSK----K 121
S L S + + + + G +C R ++ L T +
Sbjct: 57 ----STAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEAD 112
Query: 122 EFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGR 181
PCVDG++YD++ + ST V +WNLVCD L + Q +++ G+L+G+ G SDR GR
Sbjct: 113 TEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGR 172
Query: 182 RVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW 241
R+VL + M + G AAAFA + + RF LA +G ++ +ME+ ++R
Sbjct: 173 RLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPL 232
Query: 242 ASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILC---CWVLPETPFWLLSE 298
F+ G L A Y VR W L Q++ V+VPF LC W L E+ WLL+
Sbjct: 233 VMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLV---VSVPFFLCFLYSWWLAESARWLLTT 289
Query: 299 GR----YEEAQKIVDIMAKWNRASSCKLSELLS-----LDLQGPVSNSPTEVQKHNLSYL 349
GR +E ++ I K + LLS L + P ++ T ++ L +
Sbjct: 290 GRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRF- 348
Query: 350 FYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAM 409
RT L WF F+ +L+ LG N +L +GVV+IPA + +
Sbjct: 349 --------RTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLL 400
Query: 410 DKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELY 469
+GRR LA SL + L ++P + L A++G +GAAF I +Y++EL+
Sbjct: 401 SHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELF 460
Query: 470 PTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLG 529
PT++R AVG G M R +IL P L ++P L GT+ +LSG+ L LPET
Sbjct: 461 PTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQS 520
Query: 530 KRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTE 566
L T ++ +N++ T NS L+ T+
Sbjct: 521 LPLPDTIQDV-----QNQAVKKATHGTLGNSVLKSTQ 552
>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
sapiens]
Length = 506
Score = 201 bits (510), Expect = 2e-51
Identities = 149/478 (31%), Positives = 224/478 (46%), Gaps = 32/478 (6%)
Query: 7 EGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNH 66
+ I + VG G FQ+ + I + + + VF+G TP H C+ PG
Sbjct: 5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAE---LSQR 61
Query: 67 SNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRE-NTSSLG-----YEYTGSK 120
WS + + +Y L L +C R + + N S+L ++
Sbjct: 62 CGWS--------PAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNR 113
Query: 121 KEF---PCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSD 177
PC DG++YD T S+ VT++NLVC W L Q G L GS+ GYF+D
Sbjct: 114 SHLPLGPCQDGWVYD--TPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFAD 171
Query: 178 RLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMK 237
R GR++ L T + G+ AF+ +Y + + R +V+ G + G+ + EF+G
Sbjct: 172 RFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSG 231
Query: 238 SRTWASVHLHSFFAVGTLLVALTG--YLVRTWWLYQMILSTVTVPFILCCWVLPETPFWL 295
SR ++ F VG LVALTG Y + W Q+ +S T F+L W +PE+P WL
Sbjct: 232 SRRTVAIMYQMAFTVG--LVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWL 289
Query: 296 LSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSI 355
LS+ R EA KI+D +A+ N ++LSL+ TE + + LF +
Sbjct: 290 LSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLE------EDVTEKLSPSFADLFRTPRL 343
Query: 356 TKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRR 415
KRT + +WFT S+ + L+ GN YL+ +VEIP I +D+VGR
Sbjct: 344 RKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRI 403
Query: 416 TVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIV 473
+A S + AC V++ I + L ++ VG+ I A +I L AELYPT V
Sbjct: 404 YPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFV 461
>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
sapiens]
Length = 519
Score = 192 bits (489), Expect = 5e-49
Identities = 138/482 (28%), Positives = 221/482 (45%), Gaps = 35/482 (7%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65
F + VG GRFQ++ + + H F P H CRPP + +
Sbjct: 3 FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN------ 56
Query: 66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPC 125
L +G + + + G+ R + + G E G+ PC
Sbjct: 57 -----------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPC 105
Query: 126 VDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVL 185
DG+IYD +T+ ST VT+W+LVC + L L Q L+M GVLLG++ FGY +DRLGRR VL
Sbjct: 106 TDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVL 165
Query: 186 WATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVH 245
+ G AAFA ++ + A R M +G + +E++ + +R
Sbjct: 166 ILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL 225
Query: 246 LHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQ 305
+ +++G L+A Y V W Q+++S F + W E+ W S GR +
Sbjct: 226 IGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTL 285
Query: 306 KIVDIMAKWN--RASSCKLS-ELLSLDLQ-----GPVSNSPTEVQK-HNLSYLFYNWSIT 356
+ + +A+ N R KLS E+L LQ G S E+ + L +LF
Sbjct: 286 RALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLF------ 339
Query: 357 KRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRT 416
L + ++WF S +Y ++ G + YL + G V++PA + ++ +GRR
Sbjct: 340 ---LCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRP 396
Query: 417 VLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSL 476
+L + + + VIPQ I+ A++GK + A+F I+LYT ELYPT++R++
Sbjct: 397 AQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRAV 456
Query: 477 AV 478
V
Sbjct: 457 TV 458
>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
sapiens]
Length = 506
Score = 192 bits (489), Expect = 5e-49
Identities = 138/482 (28%), Positives = 221/482 (45%), Gaps = 35/482 (7%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65
F + VG GRFQ++ + + H F P H CRPP + +
Sbjct: 3 FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN------ 56
Query: 66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPC 125
L +G + + + G+ R + + G E G+ PC
Sbjct: 57 -----------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPC 105
Query: 126 VDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVL 185
DG+IYD +T+ ST VT+W+LVC + L L Q L+M GVLLG++ FGY +DRLGRR VL
Sbjct: 106 TDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVL 165
Query: 186 WATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVH 245
+ G AAFA ++ + A R M +G + +E++ + +R
Sbjct: 166 ILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL 225
Query: 246 LHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQ 305
+ +++G L+A Y V W Q+++S F + W E+ W S GR +
Sbjct: 226 IGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTL 285
Query: 306 KIVDIMAKWN--RASSCKLS-ELLSLDLQ-----GPVSNSPTEVQK-HNLSYLFYNWSIT 356
+ + +A+ N R KLS E+L LQ G S E+ + L +LF
Sbjct: 286 RALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLF------ 339
Query: 357 KRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRT 416
L + ++WF S +Y ++ G + YL + G V++PA + ++ +GRR
Sbjct: 340 ---LCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRP 396
Query: 417 VLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSL 476
+L + + + VIPQ I+ A++GK + A+F I+LYT ELYPT++R++
Sbjct: 397 AQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRAV 456
Query: 477 AV 478
V
Sbjct: 457 TV 458
>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
Length = 551
Score = 191 bits (486), Expect = 1e-48
Identities = 149/553 (26%), Positives = 249/553 (45%), Gaps = 21/553 (3%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65
F+ + D VG GRFQ L NI + + F TP H C P + V N
Sbjct: 3 FDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDN 62
Query: 66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLG----YEYTGSKK 121
DTG L + D + + + +C R L + T
Sbjct: 63 -------DTGTL---SKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPD 112
Query: 122 EFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGR 181
PCVDG++YD++++ ST VT+W+LVC+ + L ++Q LFM G LLG + +G+ SDR+GR
Sbjct: 113 TEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGR 172
Query: 182 RVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW 241
+++ + + AAFA + + RF L F+ +E+ +SR+
Sbjct: 173 KIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSM 232
Query: 242 ASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRY 301
+ L ++VG +L+ + ++ W + Q+ +ST + L W + E+ WL+ +
Sbjct: 233 TIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQL 292
Query: 302 EEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQ--KHNLSYLFYNWSITKRT 359
+E K + +A N + + E L+ +L + K ++ LF + R
Sbjct: 293 DEGLKELRRVAHINGKKNTE--ETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRV 350
Query: 360 LTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLA 419
+ + F ++ FY LN +LG N L L G V A + ++ +GRR
Sbjct: 351 FGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQI 410
Query: 420 YSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVG 479
F L V +PQ+ IL VV A +G ++ AA ++ EL PTI+RS G
Sbjct: 411 LFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAG 470
Query: 480 SGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEA 539
++ R + LAP + L + +P + G +L+ + L LPET L T ++
Sbjct: 471 INAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQD- 529
Query: 540 AKLESENESKSSK 552
+E+E +S++ K
Sbjct: 530 --VENEKDSRNIK 540
>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
Length = 541
Score = 171 bits (432), Expect = 2e-42
Identities = 141/555 (25%), Positives = 252/555 (45%), Gaps = 27/555 (4%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGI-HYLASVFMGVTPHHVCRPPGNVSQVVFH 64
FE + VG GRFQ +L+ + ++ I H L F P H C V
Sbjct: 3 FEELLSQVGGLGRFQ-MLHLVFILPSLMLLIPHILLENFAAAIPGHRC-------WVHML 54
Query: 65 NHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSL---GYEYTGSKK 121
+++ S +TG +LS +++ L + E +C R L G ++ S+
Sbjct: 55 DNNTGSGNETG-ILSEDALLRISIPLDSNLRPE--KCRRFVHPQWQLLHLNGTIHSTSEA 111
Query: 122 EF-PCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLG 180
+ PCVDG++YDQ+ + ST VT+W+LVCD + L ++Q L + G+L+G + G+ SDR G
Sbjct: 112 DTEPCVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFG 171
Query: 181 RRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRT 240
RR +L + + AAFA + + RF + + + + E+I S+
Sbjct: 172 RRFILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKA 231
Query: 241 WASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGR 300
+ ++G +++ Y+ R W ++ S F L L E+ WL+ +
Sbjct: 232 LVVILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNK 291
Query: 301 YEEAQKIVDIMAKWNRASSCKLS---ELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITK 357
+E K + +A+ N + + + E++ +Q + + T K + LF N S+ K
Sbjct: 292 LDEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQT---KTTVCDLFRNPSMRK 348
Query: 358 RTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTV 417
R + + F ++ FY +N ++G N +L L G V + + ++ +GRR
Sbjct: 349 RICILVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRIS 408
Query: 418 LAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLA 477
+F L+ +P++ L V A +G A F + ++ EL PT++R+ A
Sbjct: 409 QILFMFLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARA 468
Query: 478 VGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWE 537
G R+ + LAP + L+ + +P + G ++ G++ LPET L T +
Sbjct: 469 SGIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIK 528
Query: 538 EAAKLESENESKSSK 552
+ EN+ K+ K
Sbjct: 529 DV-----ENQKKNLK 538
>gi|157426885 organic cation transporter like 4 [Homo sapiens]
Length = 594
Score = 170 bits (431), Expect = 3e-42
Identities = 131/572 (22%), Positives = 258/572 (45%), Gaps = 61/572 (10%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65
F + D VG FG FQ+ L + +I A F+ C
Sbjct: 52 FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYC------------- 98
Query: 66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEI----------WELSRCSRNKRENTSSLGYE 115
+++W L L + Q + Q NG W L + +T +
Sbjct: 99 NTSWILAVGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDT---- 154
Query: 116 YTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYF 175
C DG+IY + K + + +++LVC + Q +FM G+ +GS+ F
Sbjct: 155 ---------CQDGWIYP-DAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLI 204
Query: 176 SDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIG 235
+D++GR + + + +FG AF ++ ++ RF ++ GY + E++
Sbjct: 205 TDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLV 264
Query: 236 MKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWL 295
+ R A + H FFAVG +L+ Y + W L ++ + +PFI W+LPE+P WL
Sbjct: 265 GEHRAHAIILGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWL 324
Query: 296 LSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSI 355
+ +G+ +EA++++ A N+ + + L +LQ P +V + ++ N +
Sbjct: 325 MMKGKVKEAKQVLCYAASVNKKT---IPSNLLDELQLP----RKKVTRASVLDFCKNRQL 377
Query: 356 TKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRR 415
K TL + +WFT S +++ SL LG + + + ++E+PA + ++GR+
Sbjct: 378 CKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRK 437
Query: 416 TVLAYSLFCSALACGVVMVIPQ---------------KHYILGVVTAMVGKFAIGAAFGL 460
LA +L + + C +++ +P+ + + ++ M+ +F++ A +
Sbjct: 438 WSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTV 497
Query: 461 IYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVL 520
+LYTAEL PT++R+ +G S+ +IL+ +S +P +A+++ L
Sbjct: 498 FFLYTAELLPTVLRATGLGLVSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSL 555
Query: 521 TLKLPETLGKRLATTWEEAAKLESENESKSSK 552
+ LPET + L+ + ++++ ++ + +K
Sbjct: 556 SSLLPETRDQPLSESLNHSSQIRNKVKDMKTK 587
>gi|42542386 solute carrier family 22 (organic anion/cation
transporter), member 9 [Homo sapiens]
Length = 553
Score = 168 bits (426), Expect = 1e-41
Identities = 144/566 (25%), Positives = 246/566 (43%), Gaps = 48/566 (8%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65
F+ + H G RFQ + + ++ +H++ F P H C V +
Sbjct: 3 FQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRC-------WVHILD 55
Query: 66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLG----YEYTGSKK 121
+ S DTGAL Q + + + +C R L + T
Sbjct: 56 NDTVSDNDTGAL---SQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDAD 112
Query: 122 EFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGR 181
PCVDG++YD+ ++ ST VT+W+LVCD + L + + +FM G+++G + G+ SDR GR
Sbjct: 113 MEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGR 172
Query: 182 RVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW 241
R VL + + G AA A + + + RF + A + + + E W
Sbjct: 173 RFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAE--------W 224
Query: 242 ASVHLHSFFAVGTLL-----------VALTGYLVRTWWLYQMILST-VTVPFILCCWVLP 289
A+ H F A+G L +A + +R W + Q+++S V F+ W+L
Sbjct: 225 AT---HRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLL- 280
Query: 290 ETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEV---QKHNL 346
E+ WL+ + EE K ++ +R+ + L+L++ E +K +L
Sbjct: 281 ESARWLIINNKPEEGLK--ELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSL 338
Query: 347 SYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVC 406
+ + +I KR + F + ++ +L+ +LG N +L L G V + A
Sbjct: 339 CEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAP 398
Query: 407 IAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTA 466
A+ + RR +F A+ ++ +PQ+ L V A +G A A L + +
Sbjct: 399 WALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGN 458
Query: 467 ELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPE 526
E+ PTI+R+ A+G + +A LAP + LS +P + G +SG L LPE
Sbjct: 459 EVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPE 518
Query: 527 TLGKRLATTWEEAAKLESENESKSSK 552
T K L T + + +NE K +
Sbjct: 519 TRNKPLFDTIQ-----DEKNERKDPR 539
>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
Length = 550
Score = 165 bits (418), Expect = 9e-41
Identities = 138/567 (24%), Positives = 247/567 (43%), Gaps = 29/567 (5%)
Query: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65
F + + G G FQ + + L F P H C
Sbjct: 3 FSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRC------------- 49
Query: 66 HSNWS-LEDTGALLSSGQ--KDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSK-- 120
W+ + D G+ +S+ K +T+ + G +C R ++ L T +
Sbjct: 50 ---WTHMLDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWS 106
Query: 121 --KEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDR 178
PCVDG++YD++ + ST V +W+LVC + L L Q +FM G+L+GS +G S R
Sbjct: 107 EADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYR 166
Query: 179 LGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKS 238
GR+ +L + + G + FA + + RF A +G + ++E+
Sbjct: 167 FGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSR 226
Query: 239 RTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSE 298
R + F+ G + + +R W Q+ S L W LPE+ WL+ +
Sbjct: 227 RAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIK 286
Query: 299 GRYEEAQKIVDIMAKWNRASSCK--LSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSIT 356
G+ ++A + + +A+ N K E+L ++ V+++ + ++ LF +
Sbjct: 287 GKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAK---EPRSVLDLFCVPVLR 343
Query: 357 KRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRT 416
R+ + ++ F+ + +Y + +LG + +L L G V+ + + +GRRT
Sbjct: 344 WRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRT 403
Query: 417 VLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSL 476
+ A S + LA M++PQ L VV A++GK G + + +Y AEL+PT VR
Sbjct: 404 IQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMT 463
Query: 477 AVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTL-KLPETLGKRLATT 535
A G V RL +++ P + +P L G +++ S ++ L LPET G L T
Sbjct: 464 ADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDT 523
Query: 536 WEEAAKLESENESKSSKLLLTTNNSGL 562
++ +S + + +T ++ L
Sbjct: 524 IQDLESQKSTAAQGNRQEAVTVESTSL 550
>gi|153791484 putative UST1-like organic anion transporter [Homo
sapiens]
Length = 547
Score = 160 bits (405), Expect = 3e-39
Identities = 120/433 (27%), Positives = 208/433 (48%), Gaps = 15/433 (3%)
Query: 124 PCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRV 183
PCVDG++YDQ+++ ST VT+W+LVC+ + L + + LFM G+++G +G+ SDR GR+
Sbjct: 115 PCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKF 174
Query: 184 VLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWAS 243
VL + + + G AAFA + + RF +V + ++E+I + A
Sbjct: 175 VLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMAL 234
Query: 244 VHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEE 303
++G + + +++R + Q+++S F L L E+ WL+ + EE
Sbjct: 235 TLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEE 294
Query: 304 AQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEV--QKHNLSYLFYNWSITKRTLT 361
K ++ +R ++L++++ E +KH+L L +I KR
Sbjct: 295 GLK--ELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICF 352
Query: 362 VWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYS 421
+ + F ++ F+ +L+ +LG N +L L G V + A A++ + RR
Sbjct: 353 LSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLL 412
Query: 422 LFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTA---ELYPTIVRSLAV 478
+F A ++ +PQ+ L VV A +G +GAA I TA EL P+I+R A
Sbjct: 413 MFLLATCLLAIIFVPQEMQTLRVVLATLG---VGAASLGITCSTAQENELIPSIIRGRAT 469
Query: 479 GSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEE 538
G + LA + LS +P + G A+LSG++ L LPET + L + ++
Sbjct: 470 GITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQD 529
Query: 539 AAKLESENESKSS 551
ENE +S
Sbjct: 530 V-----ENEGVNS 537
>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
Length = 332
Score = 132 bits (333), Expect = 7e-31
Identities = 107/348 (30%), Positives = 161/348 (46%), Gaps = 29/348 (8%)
Query: 231 MEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILC---CWV 287
ME+ ++R F+ G L A Y VR W L Q+++S VPF LC W
Sbjct: 1 MEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVS---VPFFLCFLYSWW 57
Query: 288 LPETPFWLLSEGRYE----EAQKIVDIMAKWNRASSCKLSELLS-----LDLQGPVSNSP 338
L E+ WLL+ GR + E ++ I K + LLS L + P ++
Sbjct: 58 LAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLG 117
Query: 339 TEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVE 398
T ++ L + RT L WF F+ +L+ LG N +L +GVV+
Sbjct: 118 TLLRMPGLRF---------RTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVD 168
Query: 399 IPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAF 458
IPA + + +GRR LA SL + L ++P + L A++G +GAAF
Sbjct: 169 IPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAF 228
Query: 459 GLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSG 518
I +Y++EL+PT++R AVG G M R +IL P L ++P L GT+ +LSG
Sbjct: 229 TCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSG 288
Query: 519 VLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTE 566
+ L LPET L T ++ +N++ T NS L+ T+
Sbjct: 289 LAALLLPETQSLPLPDTIQDV-----QNQAVKKATHGTLGNSVLKSTQ 331
>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
[Homo sapiens]
Length = 558
Score = 108 bits (270), Expect = 1e-23
Identities = 110/417 (26%), Positives = 177/417 (42%), Gaps = 28/417 (6%)
Query: 144 WNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAV 203
WNLVC W L Q + G LLG V G DR GRR V A+ G + A A
Sbjct: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
Query: 204 DYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYL 263
+ T + R +G L+ ++ +E R S+ F VGTLL+ L
Sbjct: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
Query: 264 VRTWWLYQMILSTVTVPFILCCW----VLPETPFWLLSEGRYEEAQKIVDIMAKWNRA-- 317
V+ W L Q L + +L W + PE+P WLL+ G+ A+KI+ A+ +
Sbjct: 239 VQDWRLLQG-LGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGP 297
Query: 318 --SSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVW----LIWFTGSL 371
SS + + L + +S + + H+ L RT W ++ F+ +
Sbjct: 298 GDSSLEENSLATATELTMLSARSPQPRYHSPLGLL-------RTRVTWRNGLILGFSSLV 350
Query: 372 GF---YSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALA 428
G SF + YL FL +E A F+ + D GRR VL + LA
Sbjct: 351 GGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLA 410
Query: 429 CGVVMVIPQKHYILG---VVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVC 485
++++ Y+ G + +++G A A L L+ AE++PT++R +G
Sbjct: 411 S--LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAG 468
Query: 486 RLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKL 542
L P F+ Q+ ++A+L+ + L LPE+ + L + ++A +L
Sbjct: 469 FLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRL 525
>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
[Homo sapiens]
Length = 560
Score = 104 bits (260), Expect = 2e-22
Identities = 109/417 (26%), Positives = 176/417 (42%), Gaps = 28/417 (6%)
Query: 144 WNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAV 203
WNLVC W L Q + G LLG V G DR GRR V A+ G + A A
Sbjct: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180
Query: 204 DYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYL 263
+ T + R +G L+ ++ +E R S+ F VGTLL+ L
Sbjct: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 240
Query: 264 VRTWWLYQMILSTVTVPFILCCW----VLPETPFWLLSEGRYEEAQKIVDIMAKWNRA-- 317
V+ W L Q L + +L W + PE+P WLL+ G+ A+KI+ A+ +
Sbjct: 241 VQDWRLLQG-LGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGP 299
Query: 318 --SSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVW----LIWFTGSL 371
SS + + L + +S + + H+ L RT W ++ F+ +
Sbjct: 300 GDSSLEENSLATATELTMLSARSPQPRYHSPLGLL-------RTRVTWRNGLILGFSSLV 352
Query: 372 GF---YSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALA 428
G SF + YL FL +E A F+ + D GRR VL + LA
Sbjct: 353 GGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLA 412
Query: 429 CGVVMVIPQKHYILG---VVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVC 485
++++ Y+ G + +++G A A L L+ AE++PT++R +G
Sbjct: 413 S--LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAG 470
Query: 486 RLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKL 542
L F+ Q+ ++A+L+ + L LPE+ + L + ++A +L
Sbjct: 471 FLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRL 527
>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
Length = 492
Score = 104 bits (260), Expect = 2e-22
Identities = 103/430 (23%), Positives = 184/430 (42%), Gaps = 59/430 (13%)
Query: 143 QWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFA 202
+W L W L+ + FG ++ S+ FG +DR GR +L + F + +FA
Sbjct: 78 EWQL---ENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFA 134
Query: 203 VDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLL-VALTG 261
Y F+ R + SG+ G + EF+ K R + F+ G+LL + L
Sbjct: 135 PSYIWFVFLRTMVGCGVSGH-SQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLAS 193
Query: 262 YLVRT--W-WLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRAS 318
++ T W WL + + S + I+ +PE+ + +S G A ++ +AK NR
Sbjct: 194 VIIPTIGWRWLIR-VASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNR-- 250
Query: 319 SCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSL 378
S + L PV ++K + + TL +W+IW S +Y L
Sbjct: 251 ----SVMPEGKLVEPV------LEKRGRFADLLDAKYLRTTLQIWVIWLGISFAYYGVIL 300
Query: 379 NSVNL------------------GG----------------NEYLNLFLLGVVEIPAYTF 404
S L GG ++Y + + + EI
Sbjct: 301 ASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPL 360
Query: 405 VCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLY 464
+ ++ +GRR L+ ++ C+AL ++ + ++G + + + + A F +Y+Y
Sbjct: 361 NILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFML--RALVAANFNTVYIY 418
Query: 465 TAELYPTIVRSLAVGSGSMVCRLASILAPF-SVDLSSIWIFIPQLFVGTMALLSGVLTLK 523
TAE+YPT +R+L +G+ +CR+ +++APF S L S I ++ ++ +
Sbjct: 419 TAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFT 478
Query: 524 LP-ETLGKRL 532
LP ET G+ L
Sbjct: 479 LPIETKGRAL 488
>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
sapiens]
Length = 520
Score = 103 bits (256), Expect = 6e-22
Identities = 102/408 (25%), Positives = 172/408 (42%), Gaps = 21/408 (5%)
Query: 138 STAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGI 197
+ A+ QW+LVCD W +L Q LF+ G G + GY +DR GRR ++ T + G+
Sbjct: 84 TNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGV 143
Query: 198 AAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLV 257
A A MA RF L + +G + ++ +E R ++ G L
Sbjct: 144 GGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLF 203
Query: 258 ALTGYLVRTWWLYQMILSTVTVPFILCCW--VLPETPFWLLSEGRYEEAQKIVDIMAKWN 315
+ + W Q +++ + F+ W + E+ WL+ + + EEAQ ++ I+A+ N
Sbjct: 204 LGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERN 263
Query: 316 RASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYS 375
R L E LQ + P N+ + L + LGF +
Sbjct: 264 RPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLI--------LGFTN 315
Query: 376 FSLNSVN-----LGG-----NEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCS 425
F +++ +GG + YL L A F+ + +D+ GRR +L S+ +
Sbjct: 316 FIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLT 375
Query: 426 ALACGVVMVIPQKHYILGVVT-AMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMV 484
+A V++ + + T +++G F+ AA L L AE+ PT VR +G +
Sbjct: 376 GIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMAL 435
Query: 485 CRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRL 532
L + P F+ + + ALL + + LPET K L
Sbjct: 436 GALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLL 483
>gi|24308167 SV2 related protein [Homo sapiens]
Length = 548
Score = 101 bits (251), Expect = 2e-21
Identities = 102/425 (24%), Positives = 183/425 (43%), Gaps = 56/425 (13%)
Query: 143 QWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFA 202
+W L W L+ + G++ S +G SD+ GR+ L + +GI +AFA
Sbjct: 114 EWRLP---SWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFA 170
Query: 203 VDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGY 262
Y + R + G +Y EF+ MK+R + + F+A+GT+ +
Sbjct: 171 PVYSWILVLRGLVGFGIGGVPQSVTLYA-EFLPMKARAKCILLIEVFWAIGTVFEVVLAV 229
Query: 263 LVRT--WWLYQMILSTVTVPF--ILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRAS 318
V W + +ILS V + +LC W LPE+ + + G E+A + +A N A
Sbjct: 230 FVMPSLGWRWLLILSAVPLLLFAVLCFW-LPESARYDVLSGNQEKAIATLKRIATENGAP 288
Query: 319 SCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSF-- 376
L +L+ +S + +L + W+ TL +W IWF+ + +Y
Sbjct: 289 M-PLGKLI-------ISRQEDRGKMRDLFTPHFRWT----TLLLWFIWFSNAFSYYGLVL 336
Query: 377 -------------------------SLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDK 411
SL L +Y++L + E P +D+
Sbjct: 337 LTTELFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDR 396
Query: 412 VGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPT 471
+GR+ +A + C +++ I +L ++ + F I F Y+YT E+YPT
Sbjct: 397 LGRKKTMALCFVIFSF-CSLLLFICVGRNVLTLLLFIARAF-ISGGFQAAYVYTPEVYPT 454
Query: 472 IVRSLAVGSGSMVCRLASILAPFSVDL---SSIWIFIPQLFVGTMALLSGVLTLKLP-ET 527
R+L +G+ S + R+ +++ PF + SS+++ + ++ G LL+ + + LP ET
Sbjct: 455 ATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTL-AVYSG-CCLLAALASCFLPIET 512
Query: 528 LGKRL 532
G+ L
Sbjct: 513 KGRGL 517
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.138 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,638,649
Number of Sequences: 37866
Number of extensions: 851172
Number of successful extensions: 2695
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 2536
Number of HSP's gapped (non-prelim): 106
length of query: 577
length of database: 18,247,518
effective HSP length: 108
effective length of query: 469
effective length of database: 14,157,990
effective search space: 6640097310
effective search space used: 6640097310
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.