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Search of human proteins with 31077205
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
sapiens]
(474 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo sa... 956 0.0
gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo sa... 922 0.0
gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo sa... 883 0.0
gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo sa... 849 0.0
gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo sa... 754 0.0
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa... 681 0.0
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens] 642 0.0
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 265 9e-71
gi|11415052 retinoid X receptor, beta [Homo sapiens] 261 7e-70
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 259 3e-69
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 229 5e-60
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 223 2e-58
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 219 3e-57
gi|238550159 estrogen-related receptor beta [Homo sapiens] 184 2e-46
gi|7657395 photoreceptor-specific nuclear receptor isoform b [Ho... 184 2e-46
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 178 8e-45
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 178 8e-45
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 178 8e-45
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 178 8e-45
gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo... 177 1e-44
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 168 1e-41
gi|18860920 estrogen-related receptor alpha [Homo sapiens] 162 8e-40
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 161 1e-39
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 161 1e-39
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 161 1e-39
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 161 1e-39
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 160 3e-39
gi|7706515 photoreceptor-specific nuclear receptor isoform a [Ho... 155 8e-38
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 145 8e-35
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 144 1e-34
>gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
sapiens]
Length = 474
Score = 956 bits (2471), Expect = 0.0
Identities = 474/474 (100%), Positives = 474/474 (100%)
Query: 1 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 60
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
Sbjct: 1 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 60
Query: 61 AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 120
AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC
Sbjct: 61 AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 120
Query: 121 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 180
FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK
Sbjct: 121 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 180
Query: 181 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 240
IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK
Sbjct: 181 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 240
Query: 241 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 300
DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK
Sbjct: 241 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 300
Query: 301 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 360
GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL
Sbjct: 301 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 360
Query: 361 FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW 420
FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW
Sbjct: 361 FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW 420
Query: 421 PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 474
PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
Sbjct: 421 PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 474
>gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo
sapiens]
Length = 464
Score = 922 bits (2383), Expect = 0.0
Identities = 463/474 (97%), Positives = 464/474 (97%), Gaps = 10/474 (2%)
Query: 1 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 60
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
Sbjct: 1 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 60
Query: 61 AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 120
AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC
Sbjct: 61 AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 120
Query: 121 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 180
FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK
Sbjct: 121 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 180
Query: 181 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 240
IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK
Sbjct: 181 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 240
Query: 241 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 300
DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK
Sbjct: 241 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 300
Query: 301 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 360
GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL
Sbjct: 301 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 360
Query: 361 FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW 420
FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQM
Sbjct: 361 FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQM--- 417
Query: 421 PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 474
+TPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
Sbjct: 418 -------STPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 464
>gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo
sapiens]
Length = 452
Score = 883 bits (2281), Expect = 0.0
Identities = 436/436 (100%), Positives = 436/436 (100%)
Query: 39 DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 98
DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF
Sbjct: 17 DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 76
Query: 99 SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 158
SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA
Sbjct: 77 SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 136
Query: 159 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 218
EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA
Sbjct: 137 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
Query: 219 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 278
LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE
Sbjct: 197 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 256
Query: 279 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 338
LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL
Sbjct: 257 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 316
Query: 339 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM 398
LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM
Sbjct: 317 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM 376
Query: 399 GTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVK 458
GTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVK
Sbjct: 377 GTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVK 436
Query: 459 PLSAIPQPTITKQEVI 474
PLSAIPQPTITKQEVI
Sbjct: 437 PLSAIPQPTITKQEVI 452
>gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
sapiens]
Length = 442
Score = 849 bits (2193), Expect = 0.0
Identities = 425/436 (97%), Positives = 426/436 (97%), Gaps = 10/436 (2%)
Query: 39 DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 98
DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF
Sbjct: 17 DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 76
Query: 99 SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 158
SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA
Sbjct: 77 SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 136
Query: 159 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 218
EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA
Sbjct: 137 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
Query: 219 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 278
LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE
Sbjct: 197 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 256
Query: 279 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 338
LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL
Sbjct: 257 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 316
Query: 339 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM 398
LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM
Sbjct: 317 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM 376
Query: 399 GTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVK 458
GTNVIVANTMPTHLSNGQM +TPETPQPSPPGGSGSEPYKLLPGAVATIVK
Sbjct: 377 GTNVIVANTMPTHLSNGQM----------STPETPQPSPPGGSGSEPYKLLPGAVATIVK 426
Query: 459 PLSAIPQPTITKQEVI 474
PLSAIPQPTITKQEVI
Sbjct: 427 PLSAIPQPTITKQEVI 442
>gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo
sapiens]
Length = 417
Score = 754 bits (1946), Expect = 0.0
Identities = 382/397 (96%), Positives = 382/397 (96%), Gaps = 13/397 (3%)
Query: 1 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 60
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
Sbjct: 1 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 60
Query: 61 AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 120
AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC
Sbjct: 61 AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 120
Query: 121 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 180
FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK
Sbjct: 121 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 180
Query: 181 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 240
IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK
Sbjct: 181 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 240
Query: 241 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 300
DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK
Sbjct: 241 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 300
Query: 301 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 360
GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL
Sbjct: 301 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 360
Query: 361 FGMAKIDNLLQEMLLGG-------------SPSDAPH 384
FGMAKIDNLLQEMLLGG SP D PH
Sbjct: 361 FGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPGDRPH 397
>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
sapiens]
Length = 395
Score = 681 bits (1756), Expect = 0.0
Identities = 344/359 (95%), Positives = 344/359 (95%), Gaps = 13/359 (3%)
Query: 39 DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 98
DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF
Sbjct: 17 DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 76
Query: 99 SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 158
SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA
Sbjct: 77 SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 136
Query: 159 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 218
EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA
Sbjct: 137 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
Query: 219 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 278
LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE
Sbjct: 197 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 256
Query: 279 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 338
LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL
Sbjct: 257 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 316
Query: 339 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG-------------SPSDAPH 384
LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG SP D PH
Sbjct: 317 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPGDRPH 375
>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
Length = 445
Score = 642 bits (1656), Expect = 0.0
Identities = 321/447 (71%), Positives = 370/447 (82%), Gaps = 13/447 (2%)
Query: 10 MDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATG 69
MDMA+YS LDP YTTLEFE +Q+L +D+S E T++N ++ GV+ LCAICGDRATG
Sbjct: 1 MDMANYSEVLDPTYTTLEFETMQILYNSSDSSAPE-TSMNTTDN-GVNCLCAICGDRATG 58
Query: 70 KHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEA 129
KHYGASSCDGCKGFFRRS+RK+H+YSCRFSRQCVVDKDKRNQCRYCRL+KCFRAGMKKEA
Sbjct: 59 KHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEA 118
Query: 130 VQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCE 189
VQNERDRISTRRS+++ S++PSIN L QAEV SRQI+ G + DI KKIASI DVCE
Sbjct: 119 VQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISVSSPGSSTDINVKKIASIGDVCE 178
Query: 190 SMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDY 249
SMK+QLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM++KD+LLLGN+Y
Sbjct: 179 SMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMYKDILLLGNNY 238
Query: 250 IVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIK 309
++ R+ E+ E+SRV+ R+LDELV PFQE+QIDDNEYA LKAI+FFDPDAKGLSDP KIK
Sbjct: 239 VIHRNSCEV-EISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIK 297
Query: 310 RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 369
+R QVQ+ LEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQF+KLFGM KIDNL
Sbjct: 298 NMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNL 357
Query: 370 LQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAAT 429
LQEMLLGG+ +D H HHP+HPHL Q+ + I+ M T + Q+ +T
Sbjct: 358 LQEMLLGGASNDGSHLHHPMHPHLSQDPLTGQTILLGPMSTLVHADQI----------ST 407
Query: 430 PETPQPSPPGGSGSEPYKLLPGAVATI 456
PETP PSPP GSG E YK+ + I
Sbjct: 408 PETPLPSPPQGSGQEQYKIAANQASVI 434
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 265 bits (676), Expect = 9e-71
Identities = 141/332 (42%), Positives = 202/332 (60%), Gaps = 12/332 (3%)
Query: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
+CAICGDR++GKHYG SC+GCKGFF+R+VRK+ Y+CR ++ C++DK +RN+C+YCR +
Sbjct: 134 ICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQ 193
Query: 119 KCFRAGMKKEAVQNERDRISTRRSSYEDSSLPS-----INALLQAEVLSRQITSPVSGIN 173
KC GMK+EAVQ ER R R + +S+ + + +L+AE+ T N
Sbjct: 194 KCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEAN 253
Query: 174 GDIRAKKIAS-IADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGA 232
+ + ++C++ +QL LVEWAK IP F ELPLDDQV LLRA E L+
Sbjct: 254 MGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASF 313
Query: 233 TKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAI 292
+ RS+ KD +LL V R+ A + + R+L ELV +++Q+D E L+AI
Sbjct: 314 SHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAI 373
Query: 293 IFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMI 352
+ F+PD+KGLS+P +++ LR +V SLE Y + + GRF +LLL LP L+SI + +
Sbjct: 374 VLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCL 433
Query: 353 EQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
E + F KL G ID L EML +APH
Sbjct: 434 EHLFFFKLIGDTPIDTFLMEML------EAPH 459
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 261 bits (668), Expect = 7e-70
Identities = 144/336 (42%), Positives = 204/336 (60%), Gaps = 19/336 (5%)
Query: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
LCAICGDR++GKHYG SC+GCKGFF+R++RK+ YSCR ++ C VDK +RN+C+YCR +
Sbjct: 204 LCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQ 263
Query: 119 KCFRAGMKKEAVQNERDRISTRRSSYEDSS-----LPSINALLQAEVLSRQ-----ITSP 168
KC GMK+EAVQ ER R + E + +P ++ +L+AE+ Q + P
Sbjct: 264 KCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP-VDRILEAELAVEQKSDQGVEGP 322
Query: 169 VSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL 228
G G + + ++C++ +QL LVEWAK IP F LPLDDQV LLRA E L
Sbjct: 323 --GGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELL 380
Query: 229 LLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAY 288
+ + RS+ +D +LL V R+ A + + R+L ELV +++++D E
Sbjct: 381 IASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGC 440
Query: 289 LKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSIT 348
L+AII F+PDAKGLS+P +++ LR +V SLE Y + + +GRF +LLL LP L+SI
Sbjct: 441 LRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIG 500
Query: 349 WQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
+ +E + F KL G ID L EML +APH
Sbjct: 501 LKCLEHLFFFKLIGDTPIDTFLMEML------EAPH 530
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 259 bits (663), Expect = 3e-69
Identities = 140/342 (40%), Positives = 207/342 (60%), Gaps = 9/342 (2%)
Query: 36 MGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYS 95
+GN PS +P SL V +CAICGDR++GKHYG SC+GCKGFF+R++RK+ +Y+
Sbjct: 121 IGNMNYPS-----TSPGSL-VKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYT 174
Query: 96 CRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL 155
CR ++ C++DK +RN+C+YCR +KC GMK+EAVQ ER R R S + + +
Sbjct: 175 CRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDM 234
Query: 156 LQAEVLSRQIT-SPVSGINGDIRAKKIAS--IADVCESMKEQLLVLVEWAKYIPAFCELP 212
+L ++ P + GD+ + + + ++C + +QL LVEWAK IP F +L
Sbjct: 235 PVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLT 294
Query: 213 LDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDEL 272
L+DQV LLRA E L+ + RS+ +D +LL V R A + + R+L EL
Sbjct: 295 LEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTEL 354
Query: 273 VLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRG 332
V +++Q+D +E L+AI+ F+PDAKGLS+P +++ LR +V +LE Y + + G
Sbjct: 355 VSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPG 414
Query: 333 RFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 374
RF +LLL LP L+SI + +E + F KL G ID L EML
Sbjct: 415 RFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 456
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 229 bits (583), Expect = 5e-60
Identities = 135/353 (38%), Positives = 191/353 (54%), Gaps = 26/353 (7%)
Query: 55 GVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRY 114
G+ C +CGD+++GKHYG +C+GCK FF+RS+R+N Y+CR +R C +D+ RNQC+Y
Sbjct: 51 GLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQY 110
Query: 115 CRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL-----------------LQ 157
CRLKKCFR GM+KEAVQ R S + S P +AL L
Sbjct: 111 CRLKKCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELI 170
Query: 158 AEVLSRQITSPVSGI--NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDD 215
A++L + +G G A + I +VCE L VEWA++ P F ELP+ D
Sbjct: 171 AQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVAD 230
Query: 216 QVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDE 271
QVALLR E +L A + ++ LL H +A V+ +R E
Sbjct: 231 QVALLRLSWSELFVLNAAQAALPLHTAPLLA---AAGLHAAPMAAERAVAFMDQVRAFQE 287
Query: 272 LVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSR 331
V LQ+D EY LKAI F PDA GLSDP ++ L+ + QV+L +Y+ +
Sbjct: 288 QVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQP 347
Query: 332 GRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
RFG LLL LP L+++ +I Q+ F++L G I+ L+++MLL GS + P+
Sbjct: 348 QRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPY 400
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 223 bits (569), Expect = 2e-58
Identities = 129/337 (38%), Positives = 194/337 (57%), Gaps = 17/337 (5%)
Query: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
Query: 120 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQIT-------SPVSGI 172
C + GM++EAVQ R R+ + ++ +L + + L LS I+ P S
Sbjct: 139 CLKVGMRREAVQ--RGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRF 196
Query: 173 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 231
++ I I ++CE L VEWA+ IP F +L + DQVALLR E +L
Sbjct: 197 GSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLN 256
Query: 232 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 287
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 257 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 313
Query: 288 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 347
LKAI+ F DA GLSD ++ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 314 CLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTV 373
Query: 348 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
+ +IEQ+ F++L G I+ L+++MLL GS + P+
Sbjct: 374 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 410
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 219 bits (559), Expect = 3e-57
Identities = 128/337 (37%), Positives = 192/337 (56%), Gaps = 17/337 (5%)
Query: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
Query: 120 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALL-------QAEVLSRQITSPVSGI 172
C + GM++EAVQ R R+ + + +L + + L +L R P S
Sbjct: 146 CLKVGMRREAVQ--RGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRY 203
Query: 173 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 231
++ I I ++CE L VEWA+ IP F +L + DQV+LLR E +L
Sbjct: 204 GSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLN 263
Query: 232 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 287
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 264 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 320
Query: 288 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 347
LKAI+ F DA GLSD I+ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 321 CLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380
Query: 348 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
+ +IEQ+ F++L G I+ L+++MLL GS + P+
Sbjct: 381 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 417
>gi|238550159 estrogen-related receptor beta [Homo sapiens]
Length = 508
Score = 184 bits (467), Expect = 2e-46
Identities = 125/415 (30%), Positives = 199/415 (47%), Gaps = 46/415 (11%)
Query: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
LC +CGD A+G HYG +SC+ CK FF+R+++ N YSC + +C + K +R C+ CR
Sbjct: 102 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 161
Query: 119 KCFRAGMKKEAVQNERDRIS----TRRSSYEDSSLPS--------------INALLQAEV 160
KC + GM KE V+ +R R RR E S S ++ LL AE
Sbjct: 162 KCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEP 221
Query: 161 LSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALL 220
P GDI+A + +C+ +L+V++ WAK+IP F L L DQ++LL
Sbjct: 222 DKLYAMPPPGMPEGDIKA-----LTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLL 276
Query: 221 RAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQ 280
++ E L+LG RS+ + D L+ DYI+ LA + + IL +LV +++L+
Sbjct: 277 QSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAIL-QLVRRYKKLK 335
Query: 281 IDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLL 340
++ E+ LKA+ + D+ + D +++L+ + +L+DY ++++ R G+LLL
Sbjct: 336 VEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLT 395
Query: 341 LPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML--------LGGSPSDAPHAHH----P 388
LP L+ + ++ +KL G + L EML L GSP D + H P
Sbjct: 396 LPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCP 455
Query: 389 LHPHLMQEHMGTNVI-VANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSG 442
+N + N P+ P P + +P PGG G
Sbjct: 456 FQSAAFTSRDQSNSPGIPNPRPSS---------PTPLNERGRQISPSTRTPGGQG 501
>gi|7657395 photoreceptor-specific nuclear receptor isoform b [Homo
sapiens]
Length = 410
Score = 184 bits (467), Expect = 2e-46
Identities = 124/370 (33%), Positives = 179/370 (48%), Gaps = 47/370 (12%)
Query: 51 PNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF-SRQCVVDKDKR 109
P + S C +CGD ++GKHYG +C+GC GFF+RSVR+ +Y C+ + C VDK R
Sbjct: 38 PTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHR 97
Query: 110 NQCRYCRLKKCFRAGMKKEAVQNERDRISTRR------SSYEDSSLPSINALLQAEVLSR 163
NQC+ CRLKKC +AGM ++AVQNER ST + S +S S+ A S
Sbjct: 98 NQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSP 157
Query: 164 QITSPVSG------------INGDIRAKKIASIAD------------------------- 186
+ +P+S I + AK AD
Sbjct: 158 RGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGL 217
Query: 187 --VCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDV-L 243
+ E+ L + V+WAK +P F LP DQV LL E LLGA + S+ L
Sbjct: 218 DSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPL 277
Query: 244 LLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS 303
L + ++ + R+L E + F+ L +D E+A +KA++ F P+ +GL
Sbjct: 278 LAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLK 337
Query: 304 DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGM 363
DP ++ L+ Q QV L + RFG+LLLLLP+L+ IT + IE + F K G
Sbjct: 338 DPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGN 397
Query: 364 AKIDNLLQEM 373
++ LL +M
Sbjct: 398 TPMEKLLCDM 407
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 178 bits (452), Expect = 8e-45
Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)
Query: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
LC +CGD A+G HYG +SC+ CK FF+R+++ N YSC + +C + K +R C+ CR
Sbjct: 104 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 163
Query: 119 KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 169
KC + GM KE V Q + RI S Y + L +++S + +
Sbjct: 164 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 223
Query: 170 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 225
I + + I ++ +C+ +L+V++ WAK+IP F L L DQ++LL++
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283
Query: 226 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 285
E L+LG RS+ F+D L+ +DYI+ +LA + ++ IL +LV ++ ++++ E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 342
Query: 286 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 345
+ LKAI + D+ + D +++L+ + +L+DY + + R G++L+ LP L+
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402
Query: 346 SITWQMIEQIQFIKLFGMAKIDNLLQEML 374
+ + ++ IKL G + L EML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 178 bits (452), Expect = 8e-45
Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)
Query: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
LC +CGD A+G HYG +SC+ CK FF+R+++ N YSC + +C + K +R C+ CR
Sbjct: 104 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 163
Query: 119 KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 169
KC + GM KE V Q + RI S Y + L +++S + +
Sbjct: 164 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 223
Query: 170 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 225
I + + I ++ +C+ +L+V++ WAK+IP F L L DQ++LL++
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283
Query: 226 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 285
E L+LG RS+ F+D L+ +DYI+ +LA + ++ IL +LV ++ ++++ E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 342
Query: 286 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 345
+ LKAI + D+ + D +++L+ + +L+DY + + R G++L+ LP L+
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402
Query: 346 SITWQMIEQIQFIKLFGMAKIDNLLQEML 374
+ + ++ IKL G + L EML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 178 bits (452), Expect = 8e-45
Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)
Query: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
LC +CGD A+G HYG +SC+ CK FF+R+++ N YSC + +C + K +R C+ CR
Sbjct: 127 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 186
Query: 119 KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 169
KC + GM KE V Q + RI S Y + L +++S + +
Sbjct: 187 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 246
Query: 170 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 225
I + + I ++ +C+ +L+V++ WAK+IP F L L DQ++LL++
Sbjct: 247 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 306
Query: 226 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 285
E L+LG RS+ F+D L+ +DYI+ +LA + ++ IL +LV ++ ++++ E
Sbjct: 307 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 365
Query: 286 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 345
+ LKAI + D+ + D +++L+ + +L+DY + + R G++L+ LP L+
Sbjct: 366 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 425
Query: 346 SITWQMIEQIQFIKLFGMAKIDNLLQEML 374
+ + ++ IKL G + L EML
Sbjct: 426 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 454
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 178 bits (452), Expect = 8e-45
Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)
Query: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
LC +CGD A+G HYG +SC+ CK FF+R+++ N YSC + +C + K +R C+ CR
Sbjct: 104 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 163
Query: 119 KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 169
KC + GM KE V Q + RI S Y + L +++S + +
Sbjct: 164 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 223
Query: 170 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 225
I + + I ++ +C+ +L+V++ WAK+IP F L L DQ++LL++
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283
Query: 226 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 285
E L+LG RS+ F+D L+ +DYI+ +LA + ++ IL +LV ++ ++++ E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 342
Query: 286 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 345
+ LKAI + D+ + D +++L+ + +L+DY + + R G++L+ LP L+
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402
Query: 346 SITWQMIEQIQFIKLFGMAKIDNLLQEML 374
+ + ++ IKL G + L EML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
>gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo
sapiens]
Length = 385
Score = 177 bits (450), Expect = 1e-44
Identities = 124/364 (34%), Positives = 178/364 (48%), Gaps = 50/364 (13%)
Query: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQ--CVVDKDKRNQCRYCRL 117
C +CGDR++GKHYG +CDGC GFF+RS+R+N Y C+ Q C VDK RNQCR CRL
Sbjct: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
Query: 118 KKCFRAGMKKEAVQNER-DRISTRR-----------------SSYEDSSLPS---INALL 156
KKC M K+AVQ+ER R ST R + + ++LP+ A+
Sbjct: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
Query: 157 QAE----VLSRQITSP---------------VSGINGDIRAKKIASIADVCESMKEQLLV 197
Q E L+ T+P +NG + VCES L +
Sbjct: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
Query: 198 LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM-VFKDVLLLGNDYIVPRHCP 256
++WAK +PAF L L DQ+ LL E +LG + ++ V + LL +
Sbjct: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
Query: 257 ELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFF-------DPDAKGLSDPGKIK 309
+ I+ L E+V F++L++D E+A LK I+ F + + + I
Sbjct: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315
Query: 310 RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 369
L+ + Q++L YI+ R RFG+LLLLLP L+SI+ IE++ F K G I L
Sbjct: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375
Query: 370 LQEM 373
L +M
Sbjct: 376 LSDM 379
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 168 bits (425), Expect = 1e-41
Identities = 111/374 (29%), Positives = 186/374 (49%), Gaps = 31/374 (8%)
Query: 35 TMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMY 94
T + PS + L P V C +C D+++G HYG S+C+GCKGFFRRS++KN +Y
Sbjct: 59 TSSEELVPSPPSPLPPPR---VYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIY 115
Query: 95 SCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINA 154
+C + CV++K RN+C+YCRL+KCF GM KE+V+N+R++ S E + + A
Sbjct: 116 TCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTA 175
Query: 155 LLQ--AEVLSR----------QITSPVSGINGDIRAKKIASIADVCESMKEQLLV-LVEW 201
L E + + Q+ + + D R + + D + + ++ +VE+
Sbjct: 176 ELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEF 235
Query: 202 AKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEM 261
AK +P F L + DQ+ LL+A + L+L R +D + + + R +M
Sbjct: 236 AKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR-----TQM 290
Query: 262 SRVSIRILDELVLPFQE----LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQV 317
L +LV F L++DD E L AI D + L +P K+ +L+ +
Sbjct: 291 HNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLE 350
Query: 318 SLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG 377
+L+ YI R+ F ++L+ + L+SI+ + E++ +K+ + L+QEML
Sbjct: 351 ALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEML--- 407
Query: 378 SPSDAPHAHHPLHP 391
+ H PL P
Sbjct: 408 ---ENSEGHEPLTP 418
>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
Length = 423
Score = 162 bits (409), Expect = 8e-40
Identities = 102/346 (29%), Positives = 169/346 (48%), Gaps = 35/346 (10%)
Query: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
LC +CGD A+G HYG +SC+ CK FF+R+++ + YSC S +C + K +R C+ CR
Sbjct: 78 LCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFT 137
Query: 119 KCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL----------LQAEVLSRQITSP 168
KC R GM KE V+ DR+ R Y+ P ++ L L R+ +P
Sbjct: 138 KCLRVGMLKEGVR--LDRVRGGRQKYK--RRPEVDPLPFPGPFPAGPLAVAGGPRKTAAP 193
Query: 169 VSGINGDIRAKK----------------IASIADVCESMKEQLLVLVEWAKYIPAFCELP 212
V+ + + + + ++A +C+ +++V + WAK IP F L
Sbjct: 194 VNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLS 253
Query: 213 LDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDEL 272
L DQ+++L++ E L+LG +RS+ +D L D ++ A + + +L +L
Sbjct: 254 LSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALL-QL 312
Query: 273 VLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRG 332
V Q L+++ EY LKA+ + D+ + D +++LR + +L +Y R G
Sbjct: 313 VRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGG 372
Query: 333 ----RFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 374
R G LLL LP L+ +++ +KL G + L EML
Sbjct: 373 AERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEML 418
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 161 bits (407), Expect = 1e-39
Identities = 97/332 (29%), Positives = 171/332 (51%), Gaps = 22/332 (6%)
Query: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+C + C+++K RN+C+YCRL+K
Sbjct: 88 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 147
Query: 120 CFRAGMKKEAVQNERDR----ISTRRSSYEDSSLPSINALLQAEVLSRQITSPV-----S 170
CF GM KE+V+N+R++ + S + P + L++ + Q T P
Sbjct: 148 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 207
Query: 171 GINGDIRAKKIASIADVCESMKEQ----LLVLVEWAKYIPAFCELPLDDQVALLRAHAGE 226
+ ++++ D+ + E ++ VE+AK +P F L + DQ+ LL+A +
Sbjct: 208 YTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 267
Query: 227 HLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE----LQID 282
L+L R +D + + + R +M L +LV F L++D
Sbjct: 268 ILILRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFANQLLPLEMD 322
Query: 283 DNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLP 342
D E L AI D + L P ++ L+ + +L+ Y+ R+ F ++L+ +
Sbjct: 323 DAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT 382
Query: 343 TLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 374
L+SI+ + E++ +K+ + L+QEML
Sbjct: 383 DLRSISAKGAERVITLKMEIPGSMPPLIQEML 414
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 161 bits (407), Expect = 1e-39
Identities = 97/332 (29%), Positives = 171/332 (51%), Gaps = 22/332 (6%)
Query: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+C + C+++K RN+C+YCRL+K
Sbjct: 83 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 142
Query: 120 CFRAGMKKEAVQNERDR----ISTRRSSYEDSSLPSINALLQAEVLSRQITSPV-----S 170
CF GM KE+V+N+R++ + S + P + L++ + Q T P
Sbjct: 143 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 202
Query: 171 GINGDIRAKKIASIADVCESMKEQ----LLVLVEWAKYIPAFCELPLDDQVALLRAHAGE 226
+ ++++ D+ + E ++ VE+AK +P F L + DQ+ LL+A +
Sbjct: 203 YTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 262
Query: 227 HLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE----LQID 282
L+L R +D + + + R +M L +LV F L++D
Sbjct: 263 ILILRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFANQLLPLEMD 317
Query: 283 DNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLP 342
D E L AI D + L P ++ L+ + +L+ Y+ R+ F ++L+ +
Sbjct: 318 DAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT 377
Query: 343 TLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 374
L+SI+ + E++ +K+ + L+QEML
Sbjct: 378 DLRSISAKGAERVITLKMEIPGSMPPLIQEML 409
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 161 bits (407), Expect = 1e-39
Identities = 97/332 (29%), Positives = 171/332 (51%), Gaps = 22/332 (6%)
Query: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+C + C+++K RN+C+YCRL+K
Sbjct: 88 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 147
Query: 120 CFRAGMKKEAVQNERDR----ISTRRSSYEDSSLPSINALLQAEVLSRQITSPV-----S 170
CF GM KE+V+N+R++ + S + P + L++ + Q T P
Sbjct: 148 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 207
Query: 171 GINGDIRAKKIASIADVCESMKEQ----LLVLVEWAKYIPAFCELPLDDQVALLRAHAGE 226
+ ++++ D+ + E ++ VE+AK +P F L + DQ+ LL+A +
Sbjct: 208 YTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 267
Query: 227 HLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE----LQID 282
L+L R +D + + + R +M L +LV F L++D
Sbjct: 268 ILILRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFANQLLPLEMD 322
Query: 283 DNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLP 342
D E L AI D + L P ++ L+ + +L+ Y+ R+ F ++L+ +
Sbjct: 323 DAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT 382
Query: 343 TLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 374
L+SI+ + E++ +K+ + L+QEML
Sbjct: 383 DLRSISAKGAERVITLKMEIPGSMPPLIQEML 414
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 161 bits (407), Expect = 1e-39
Identities = 110/389 (28%), Positives = 185/389 (47%), Gaps = 26/389 (6%)
Query: 27 EFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRR 86
E ++ V T + ++ + P V C +C D+++G HYG SSC+GCKGFFRR
Sbjct: 57 EMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRR 116
Query: 87 SVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTR------ 140
S++KN +Y+C + C+++K RN+C+YCRL+KCF GM KEAV+N+R++
Sbjct: 117 SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGS 176
Query: 141 RSSYEDSSLPSINALLQAEVLSRQITSP--------VSGINGDIRAKKIASIADVCESMK 192
SYE S P + L+ + Q T P + + D R + + D +
Sbjct: 177 PDSYELS--PQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELA 234
Query: 193 EQLLV-LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIV 251
+ ++ +VE+AK +P F L + DQ+ LL+A + L+L R +D + + +
Sbjct: 235 TKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTL 294
Query: 252 PRHCPELAEMSRVSIRILDELVLPFQ----ELQIDDNEYAYLKAIIFFDPDAKGLSDPGK 307
R +M L +LV F L++DD E L AI D L +P K
Sbjct: 295 NR-----TQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEK 349
Query: 308 IKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKID 367
+ +L+ + +L Y R+ F +L+ + L+ I+ + E+ +K+ +
Sbjct: 350 VDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMP 409
Query: 368 NLLQEMLLGGSPSDAPHAHHPLHPHLMQE 396
L++EML + + HP+ E
Sbjct: 410 PLIREMLENPEMFEDDSSQPGPHPNASSE 438
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 160 bits (404), Expect = 3e-39
Identities = 105/356 (29%), Positives = 174/356 (48%), Gaps = 26/356 (7%)
Query: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
C +C D+++G HYG SSC+GCKGFFRRS++KN +Y+C + C+++K RN+C+YCRL+K
Sbjct: 79 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 138
Query: 120 CFRAGMKKEAVQNERDRISTR------RSSYEDSSLPSINALLQAEVLSRQITSP----- 168
CF GM KEAV+N+R++ SYE S P + L+ + Q T P
Sbjct: 139 CFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELS--PQLEELITKVSKAHQETFPSLCQL 196
Query: 169 ---VSGINGDIRAKKIASIADVCESMKEQLLV-LVEWAKYIPAFCELPLDDQVALLRAHA 224
+ + D R + + D + + ++ +VE+AK +P F L + DQ+ LL+A
Sbjct: 197 GKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAAC 256
Query: 225 GEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQ----ELQ 280
+ L+L R +D + + + R +M L +LV F L+
Sbjct: 257 LDILMLRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFAGQLLPLE 311
Query: 281 IDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLL 340
+DD E L AI D L +P K+ +L+ + +L Y R+ F +L+
Sbjct: 312 MDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMK 371
Query: 341 LPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQE 396
+ L+ I+ + E+ +K+ + L++EML + + HP+ E
Sbjct: 372 ITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSE 427
>gi|7706515 photoreceptor-specific nuclear receptor isoform a [Homo
sapiens]
Length = 367
Score = 155 bits (392), Expect = 8e-38
Identities = 104/319 (32%), Positives = 151/319 (47%), Gaps = 47/319 (14%)
Query: 51 PNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF-SRQCVVDKDKR 109
P + S C +CGD ++GKHYG +C+GC GFF+RSVR+ +Y C+ + C VDK R
Sbjct: 38 PTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHR 97
Query: 110 NQCRYCRLKKCFRAGMKKEAVQNERDRISTRR------SSYEDSSLPSINALLQAEVLSR 163
NQC+ CRLKKC +AGM ++AVQNER ST + S +S S+ A S
Sbjct: 98 NQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSP 157
Query: 164 QITSPVSG------------INGDIRAKKIASIAD------------------------- 186
+ +P+S I + AK AD
Sbjct: 158 RGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGL 217
Query: 187 --VCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDV-L 243
+ E+ L + V+WAK +P F LP DQV LL E LLGA + S+ L
Sbjct: 218 DSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPL 277
Query: 244 LLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS 303
L + ++ + R+L E + F+ L +D E+A +KA++ F P+ +GL
Sbjct: 278 LAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLK 337
Query: 304 DPGKIKRLRSQVQVSLEDY 322
DP ++ L+ Q QV L +
Sbjct: 338 DPEHVEALQDQSQVMLSQH 356
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 145 bits (366), Expect = 8e-35
Identities = 106/370 (28%), Positives = 183/370 (49%), Gaps = 36/370 (9%)
Query: 32 QVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKN 91
Q+L + PS G+ N LCA+CGD A +HYG +C+GCKGFF+R+V+KN
Sbjct: 242 QLLDTQVPSPPSRGSPSN-------EGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKN 294
Query: 92 HMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNE-----RDRISTRRSSYED 146
Y C ++ C VDK +RN+C+YCR +KC GM KE V+ + R R+ ++ S ++
Sbjct: 295 AKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQE 354
Query: 147 SSLPS-----INALLQAEV----------LSRQITSPVSGINGDIRAKKIASIADVCESM 191
S PS I+AL++A V SR +P ++GD + I D+
Sbjct: 355 PSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGD-DTQHIQQFYDLLTGS 413
Query: 192 KEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIV 251
E ++ WA+ IP F +LP DQ L + E +L RS + L+ N ++
Sbjct: 414 ME---IIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVL 470
Query: 252 PRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRL 311
H + I + E Q + ID + ++ + A+ + GL +P +++ L
Sbjct: 471 --HRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMV-TERHGLKEPKRVEEL 527
Query: 312 RSQVQVSLEDYI--NDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 369
++++ L+D++ N+ + +LL LP L+++ Q +++I ++KL + +
Sbjct: 528 QNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAI 587
Query: 370 LQEMLLGGSP 379
+ ++ L P
Sbjct: 588 IDKLFLDTLP 597
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 144 bits (364), Expect = 1e-34
Identities = 99/335 (29%), Positives = 158/335 (47%), Gaps = 39/335 (11%)
Query: 51 PNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKN--HMYSCRFSRQCVVDKDK 108
P+ L LC +CGD+ATG HY +C+GCKGFFRR+++KN YSC++ +CV+DK
Sbjct: 98 PSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVT 157
Query: 109 RNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA---------- 158
RNQC+ CR KKC GM + V ++ R++ R+ E+ L ++
Sbjct: 158 RNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDE 217
Query: 159 ------EVLSRQITSPVSGINGDIRAKKI------ASIADVCESMKEQLLV--------- 197
V + + G + + K + A I + E K L
Sbjct: 218 EWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIIT 277
Query: 198 -----LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVP 252
+V++AK +P FCELP +DQ+ LL+ E + L A R + L L + V
Sbjct: 278 PAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVT 337
Query: 253 RHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLR 312
R + + VS I D L + +DD E A L+A++ D GL+ +I++ +
Sbjct: 338 RGQLKNGGLGVVSDAIFD-LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQ 396
Query: 313 SQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 347
++ E YIN R++ + +LL+ + L+ I
Sbjct: 397 DSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMI 431
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,044,410
Number of Sequences: 37866
Number of extensions: 943093
Number of successful extensions: 5310
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 121
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 4883
Number of HSP's gapped (non-prelim): 345
length of query: 474
length of database: 18,247,518
effective HSP length: 106
effective length of query: 368
effective length of database: 14,233,722
effective search space: 5238009696
effective search space used: 5238009696
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.