Guide to the Human Genome
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Search of human proteins with 31077205

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
sapiens]
         (474 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo sa...   956   0.0  
gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo sa...   922   0.0  
gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo sa...   883   0.0  
gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo sa...   849   0.0  
gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo sa...   754   0.0  
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa...   681   0.0  
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]        642   0.0  
gi|4506755 retinoid X receptor, alpha [Homo sapiens]                  265   9e-71
gi|11415052 retinoid X receptor, beta [Homo sapiens]                  261   7e-70
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]        259   3e-69
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom...   229   5e-60
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof...   223   2e-58
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo...   219   3e-57
gi|238550159 estrogen-related receptor beta [Homo sapiens]            184   2e-46
gi|7657395 photoreceptor-specific nuclear receptor isoform b [Ho...   184   2e-46
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi...   178   8e-45
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi...   178   8e-45
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi...   178   8e-45
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap...   178   8e-45
gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo...   177   1e-44
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]     168   1e-41
gi|18860920 estrogen-related receptor alpha [Homo sapiens]            162   8e-40
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]   161   1e-39
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]    161   1e-39
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]     161   1e-39
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]     161   1e-39
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]   160   3e-39
gi|7706515 photoreceptor-specific nuclear receptor isoform a [Ho...   155   8e-38
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo...   145   8e-35
gi|189491771 thyroid hormone receptor, beta [Homo sapiens]            144   1e-34

>gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
           sapiens]
          Length = 474

 Score =  956 bits (2471), Expect = 0.0
 Identities = 474/474 (100%), Positives = 474/474 (100%)

Query: 1   MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 60
           MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
Sbjct: 1   MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 60

Query: 61  AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 120
           AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC
Sbjct: 61  AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 120

Query: 121 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 180
           FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK
Sbjct: 121 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 180

Query: 181 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 240
           IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK
Sbjct: 181 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 240

Query: 241 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 300
           DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK
Sbjct: 241 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 300

Query: 301 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 360
           GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL
Sbjct: 301 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 360

Query: 361 FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW 420
           FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW
Sbjct: 361 FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW 420

Query: 421 PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 474
           PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
Sbjct: 421 PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 474


>gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo
           sapiens]
          Length = 464

 Score =  922 bits (2383), Expect = 0.0
 Identities = 463/474 (97%), Positives = 464/474 (97%), Gaps = 10/474 (2%)

Query: 1   MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 60
           MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
Sbjct: 1   MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 60

Query: 61  AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 120
           AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC
Sbjct: 61  AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 120

Query: 121 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 180
           FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK
Sbjct: 121 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 180

Query: 181 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 240
           IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK
Sbjct: 181 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 240

Query: 241 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 300
           DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK
Sbjct: 241 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 300

Query: 301 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 360
           GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL
Sbjct: 301 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 360

Query: 361 FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW 420
           FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQM   
Sbjct: 361 FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQM--- 417

Query: 421 PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 474
                  +TPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
Sbjct: 418 -------STPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 464


>gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo
           sapiens]
          Length = 452

 Score =  883 bits (2281), Expect = 0.0
 Identities = 436/436 (100%), Positives = 436/436 (100%)

Query: 39  DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 98
           DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF
Sbjct: 17  DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 76

Query: 99  SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 158
           SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA
Sbjct: 77  SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 136

Query: 159 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 218
           EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA
Sbjct: 137 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196

Query: 219 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 278
           LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE
Sbjct: 197 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 256

Query: 279 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 338
           LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL
Sbjct: 257 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 316

Query: 339 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM 398
           LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM
Sbjct: 317 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM 376

Query: 399 GTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVK 458
           GTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVK
Sbjct: 377 GTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVK 436

Query: 459 PLSAIPQPTITKQEVI 474
           PLSAIPQPTITKQEVI
Sbjct: 437 PLSAIPQPTITKQEVI 452


>gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
           sapiens]
          Length = 442

 Score =  849 bits (2193), Expect = 0.0
 Identities = 425/436 (97%), Positives = 426/436 (97%), Gaps = 10/436 (2%)

Query: 39  DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 98
           DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF
Sbjct: 17  DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 76

Query: 99  SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 158
           SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA
Sbjct: 77  SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 136

Query: 159 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 218
           EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA
Sbjct: 137 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196

Query: 219 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 278
           LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE
Sbjct: 197 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 256

Query: 279 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 338
           LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL
Sbjct: 257 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 316

Query: 339 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM 398
           LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM
Sbjct: 317 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM 376

Query: 399 GTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVK 458
           GTNVIVANTMPTHLSNGQM          +TPETPQPSPPGGSGSEPYKLLPGAVATIVK
Sbjct: 377 GTNVIVANTMPTHLSNGQM----------STPETPQPSPPGGSGSEPYKLLPGAVATIVK 426

Query: 459 PLSAIPQPTITKQEVI 474
           PLSAIPQPTITKQEVI
Sbjct: 427 PLSAIPQPTITKQEVI 442


>gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo
           sapiens]
          Length = 417

 Score =  754 bits (1946), Expect = 0.0
 Identities = 382/397 (96%), Positives = 382/397 (96%), Gaps = 13/397 (3%)

Query: 1   MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 60
           MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
Sbjct: 1   MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 60

Query: 61  AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 120
           AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC
Sbjct: 61  AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 120

Query: 121 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 180
           FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK
Sbjct: 121 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 180

Query: 181 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 240
           IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK
Sbjct: 181 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 240

Query: 241 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 300
           DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK
Sbjct: 241 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 300

Query: 301 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 360
           GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL
Sbjct: 301 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 360

Query: 361 FGMAKIDNLLQEMLLGG-------------SPSDAPH 384
           FGMAKIDNLLQEMLLGG             SP D PH
Sbjct: 361 FGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPGDRPH 397


>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
           sapiens]
          Length = 395

 Score =  681 bits (1756), Expect = 0.0
 Identities = 344/359 (95%), Positives = 344/359 (95%), Gaps = 13/359 (3%)

Query: 39  DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 98
           DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF
Sbjct: 17  DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 76

Query: 99  SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 158
           SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA
Sbjct: 77  SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 136

Query: 159 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 218
           EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA
Sbjct: 137 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196

Query: 219 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 278
           LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE
Sbjct: 197 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 256

Query: 279 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 338
           LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL
Sbjct: 257 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 316

Query: 339 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG-------------SPSDAPH 384
           LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG             SP D PH
Sbjct: 317 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPGDRPH 375


>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
          Length = 445

 Score =  642 bits (1656), Expect = 0.0
 Identities = 321/447 (71%), Positives = 370/447 (82%), Gaps = 13/447 (2%)

Query: 10  MDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATG 69
           MDMA+YS  LDP YTTLEFE +Q+L   +D+S  E T++N  ++ GV+ LCAICGDRATG
Sbjct: 1   MDMANYSEVLDPTYTTLEFETMQILYNSSDSSAPE-TSMNTTDN-GVNCLCAICGDRATG 58

Query: 70  KHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEA 129
           KHYGASSCDGCKGFFRRS+RK+H+YSCRFSRQCVVDKDKRNQCRYCRL+KCFRAGMKKEA
Sbjct: 59  KHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEA 118

Query: 130 VQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCE 189
           VQNERDRISTRRS+++ S++PSIN L QAEV SRQI+    G + DI  KKIASI DVCE
Sbjct: 119 VQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISVSSPGSSTDINVKKIASIGDVCE 178

Query: 190 SMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDY 249
           SMK+QLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM++KD+LLLGN+Y
Sbjct: 179 SMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMYKDILLLGNNY 238

Query: 250 IVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIK 309
           ++ R+  E+ E+SRV+ R+LDELV PFQE+QIDDNEYA LKAI+FFDPDAKGLSDP KIK
Sbjct: 239 VIHRNSCEV-EISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIK 297

Query: 310 RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 369
            +R QVQ+ LEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQF+KLFGM KIDNL
Sbjct: 298 NMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNL 357

Query: 370 LQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAAT 429
           LQEMLLGG+ +D  H HHP+HPHL Q+ +    I+   M T +   Q+          +T
Sbjct: 358 LQEMLLGGASNDGSHLHHPMHPHLSQDPLTGQTILLGPMSTLVHADQI----------ST 407

Query: 430 PETPQPSPPGGSGSEPYKLLPGAVATI 456
           PETP PSPP GSG E YK+     + I
Sbjct: 408 PETPLPSPPQGSGQEQYKIAANQASVI 434


>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
          Length = 462

 Score =  265 bits (676), Expect = 9e-71
 Identities = 141/332 (42%), Positives = 202/332 (60%), Gaps = 12/332 (3%)

Query: 59  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
           +CAICGDR++GKHYG  SC+GCKGFF+R+VRK+  Y+CR ++ C++DK +RN+C+YCR +
Sbjct: 134 ICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQ 193

Query: 119 KCFRAGMKKEAVQNERDRISTRRSSYEDSSLPS-----INALLQAEVLSRQITSPVSGIN 173
           KC   GMK+EAVQ ER R   R  +  +S+  +     +  +L+AE+     T      N
Sbjct: 194 KCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEAN 253

Query: 174 GDIRAKKIAS-IADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGA 232
             +        + ++C++  +QL  LVEWAK IP F ELPLDDQV LLRA   E L+   
Sbjct: 254 MGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASF 313

Query: 233 TKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAI 292
           + RS+  KD +LL     V R+    A +  +  R+L ELV   +++Q+D  E   L+AI
Sbjct: 314 SHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAI 373

Query: 293 IFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMI 352
           + F+PD+KGLS+P +++ LR +V  SLE Y   +  +  GRF +LLL LP L+SI  + +
Sbjct: 374 VLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCL 433

Query: 353 EQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
           E + F KL G   ID  L EML      +APH
Sbjct: 434 EHLFFFKLIGDTPIDTFLMEML------EAPH 459


>gi|11415052 retinoid X receptor, beta [Homo sapiens]
          Length = 533

 Score =  261 bits (668), Expect = 7e-70
 Identities = 144/336 (42%), Positives = 204/336 (60%), Gaps = 19/336 (5%)

Query: 59  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
           LCAICGDR++GKHYG  SC+GCKGFF+R++RK+  YSCR ++ C VDK +RN+C+YCR +
Sbjct: 204 LCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQ 263

Query: 119 KCFRAGMKKEAVQNERDRISTRRSSYEDSS-----LPSINALLQAEVLSRQ-----ITSP 168
           KC   GMK+EAVQ ER R   +    E +      +P ++ +L+AE+   Q     +  P
Sbjct: 264 KCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP-VDRILEAELAVEQKSDQGVEGP 322

Query: 169 VSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL 228
             G  G   +     + ++C++  +QL  LVEWAK IP F  LPLDDQV LLRA   E L
Sbjct: 323 --GGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELL 380

Query: 229 LLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAY 288
           +   + RS+  +D +LL     V R+    A +  +  R+L ELV   +++++D  E   
Sbjct: 381 IASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGC 440

Query: 289 LKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSIT 348
           L+AII F+PDAKGLS+P +++ LR +V  SLE Y   +  + +GRF +LLL LP L+SI 
Sbjct: 441 LRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIG 500

Query: 349 WQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
            + +E + F KL G   ID  L EML      +APH
Sbjct: 501 LKCLEHLFFFKLIGDTPIDTFLMEML------EAPH 530


>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
          Length = 463

 Score =  259 bits (663), Expect = 3e-69
 Identities = 140/342 (40%), Positives = 207/342 (60%), Gaps = 9/342 (2%)

Query: 36  MGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYS 95
           +GN   PS      +P SL V  +CAICGDR++GKHYG  SC+GCKGFF+R++RK+ +Y+
Sbjct: 121 IGNMNYPS-----TSPGSL-VKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYT 174

Query: 96  CRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL 155
           CR ++ C++DK +RN+C+YCR +KC   GMK+EAVQ ER R   R  S  + +      +
Sbjct: 175 CRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDM 234

Query: 156 LQAEVLSRQIT-SPVSGINGDIRAKKIAS--IADVCESMKEQLLVLVEWAKYIPAFCELP 212
               +L  ++   P +   GD+  +   +  + ++C +  +QL  LVEWAK IP F +L 
Sbjct: 235 PVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLT 294

Query: 213 LDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDEL 272
           L+DQV LLRA   E L+   + RS+  +D +LL     V R     A +  +  R+L EL
Sbjct: 295 LEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTEL 354

Query: 273 VLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRG 332
           V   +++Q+D +E   L+AI+ F+PDAKGLS+P +++ LR +V  +LE Y   +  +  G
Sbjct: 355 VSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPG 414

Query: 333 RFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 374
           RF +LLL LP L+SI  + +E + F KL G   ID  L EML
Sbjct: 415 RFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 456


>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
           sapiens]
          Length = 404

 Score =  229 bits (583), Expect = 5e-60
 Identities = 135/353 (38%), Positives = 191/353 (54%), Gaps = 26/353 (7%)

Query: 55  GVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRY 114
           G+   C +CGD+++GKHYG  +C+GCK FF+RS+R+N  Y+CR +R C +D+  RNQC+Y
Sbjct: 51  GLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQY 110

Query: 115 CRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL-----------------LQ 157
           CRLKKCFR GM+KEAVQ  R   S   +    S  P  +AL                 L 
Sbjct: 111 CRLKKCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELI 170

Query: 158 AEVLSRQITSPVSGI--NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDD 215
           A++L  +     +G    G   A  +  I +VCE     L   VEWA++ P F ELP+ D
Sbjct: 171 AQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVAD 230

Query: 216 QVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDE 271
           QVALLR    E  +L A + ++      LL        H   +A    V+    +R   E
Sbjct: 231 QVALLRLSWSELFVLNAAQAALPLHTAPLLA---AAGLHAAPMAAERAVAFMDQVRAFQE 287

Query: 272 LVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSR 331
            V     LQ+D  EY  LKAI  F PDA GLSDP  ++ L+ + QV+L +Y+  +     
Sbjct: 288 QVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQP 347

Query: 332 GRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
            RFG LLL LP L+++   +I Q+ F++L G   I+ L+++MLL GS  + P+
Sbjct: 348 QRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPY 400


>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
           a [Homo sapiens]
          Length = 414

 Score =  223 bits (569), Expect = 2e-58
 Identities = 129/337 (38%), Positives = 194/337 (57%), Gaps = 17/337 (5%)

Query: 60  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
           C +CGD+++GKHYG  +C+GCK FF+RSVR+N  Y+CR +R C +D+  RNQC+YCRLKK
Sbjct: 79  CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138

Query: 120 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQIT-------SPVSGI 172
           C + GM++EAVQ  R R+   + ++   +L + + L     LS  I+        P S  
Sbjct: 139 CLKVGMRREAVQ--RGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRF 196

Query: 173 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 231
               ++   I  I ++CE     L   VEWA+ IP F +L + DQVALLR    E  +L 
Sbjct: 197 GSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLN 256

Query: 232 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 287
           A + SM      LL        H   ++    V+    IRI  E V   + L +D  EY+
Sbjct: 257 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 313

Query: 288 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 347
            LKAI+ F  DA GLSD   ++ L+ + Q +LE+Y+  +  +   RFG+LLL LP+L+++
Sbjct: 314 CLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTV 373

Query: 348 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
           +  +IEQ+ F++L G   I+ L+++MLL GS  + P+
Sbjct: 374 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 410


>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
           sapiens]
          Length = 423

 Score =  219 bits (559), Expect = 3e-57
 Identities = 128/337 (37%), Positives = 192/337 (56%), Gaps = 17/337 (5%)

Query: 60  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
           C +CGD+++GKHYG  +C+GCK FF+RSVR+N  Y+CR +R C +D+  RNQC+YCRLKK
Sbjct: 86  CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145

Query: 120 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALL-------QAEVLSRQITSPVSGI 172
           C + GM++EAVQ  R R+   + +    +L + + L           +L R    P S  
Sbjct: 146 CLKVGMRREAVQ--RGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRY 203

Query: 173 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 231
               ++   I  I ++CE     L   VEWA+ IP F +L + DQV+LLR    E  +L 
Sbjct: 204 GSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLN 263

Query: 232 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 287
           A + SM      LL        H   ++    V+    IRI  E V   + L +D  EY+
Sbjct: 264 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 320

Query: 288 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 347
            LKAI+ F  DA GLSD   I+ L+ + Q +LE+Y+  +  +   RFG+LLL LP+L+++
Sbjct: 321 CLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380

Query: 348 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
           +  +IEQ+ F++L G   I+ L+++MLL GS  + P+
Sbjct: 381 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 417


>gi|238550159 estrogen-related receptor beta [Homo sapiens]
          Length = 508

 Score =  184 bits (467), Expect = 2e-46
 Identities = 125/415 (30%), Positives = 199/415 (47%), Gaps = 46/415 (11%)

Query: 59  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
           LC +CGD A+G HYG +SC+ CK FF+R+++ N  YSC  + +C + K +R  C+ CR  
Sbjct: 102 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 161

Query: 119 KCFRAGMKKEAVQNERDRIS----TRRSSYEDSSLPS--------------INALLQAEV 160
           KC + GM KE V+ +R R       RR   E S   S              ++ LL AE 
Sbjct: 162 KCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEP 221

Query: 161 LSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALL 220
                  P     GDI+A     +  +C+    +L+V++ WAK+IP F  L L DQ++LL
Sbjct: 222 DKLYAMPPPGMPEGDIKA-----LTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLL 276

Query: 221 RAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQ 280
           ++   E L+LG   RS+ + D L+   DYI+      LA +  +   IL +LV  +++L+
Sbjct: 277 QSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAIL-QLVRRYKKLK 335

Query: 281 IDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLL 340
           ++  E+  LKA+   + D+  + D   +++L+  +  +L+DY   ++++   R G+LLL 
Sbjct: 336 VEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLT 395

Query: 341 LPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML--------LGGSPSDAPHAHH----P 388
           LP L+    + ++    +KL G   +  L  EML        L GSP D   + H    P
Sbjct: 396 LPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCP 455

Query: 389 LHPHLMQEHMGTNVI-VANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSG 442
                      +N   + N  P+          P P  +     +P    PGG G
Sbjct: 456 FQSAAFTSRDQSNSPGIPNPRPSS---------PTPLNERGRQISPSTRTPGGQG 501


>gi|7657395 photoreceptor-specific nuclear receptor isoform b [Homo
           sapiens]
          Length = 410

 Score =  184 bits (467), Expect = 2e-46
 Identities = 124/370 (33%), Positives = 179/370 (48%), Gaps = 47/370 (12%)

Query: 51  PNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF-SRQCVVDKDKR 109
           P  +  S  C +CGD ++GKHYG  +C+GC GFF+RSVR+  +Y C+  +  C VDK  R
Sbjct: 38  PTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHR 97

Query: 110 NQCRYCRLKKCFRAGMKKEAVQNERDRISTRR------SSYEDSSLPSINALLQAEVLSR 163
           NQC+ CRLKKC +AGM ++AVQNER   ST +       S  +S   S+ A       S 
Sbjct: 98  NQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSP 157

Query: 164 QITSPVSG------------INGDIRAKKIASIAD------------------------- 186
           +  +P+S             I  +  AK     AD                         
Sbjct: 158 RGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGL 217

Query: 187 --VCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDV-L 243
             + E+    L + V+WAK +P F  LP  DQV LL     E  LLGA + S+      L
Sbjct: 218 DSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPL 277

Query: 244 LLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS 303
           L   +            ++ +  R+L E +  F+ L +D  E+A +KA++ F P+ +GL 
Sbjct: 278 LAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLK 337

Query: 304 DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGM 363
           DP  ++ L+ Q QV L  +          RFG+LLLLLP+L+ IT + IE + F K  G 
Sbjct: 338 DPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGN 397

Query: 364 AKIDNLLQEM 373
             ++ LL +M
Sbjct: 398 TPMEKLLCDM 407


>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
           sapiens]
          Length = 435

 Score =  178 bits (452), Expect = 8e-45
 Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)

Query: 59  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
           LC +CGD A+G HYG +SC+ CK FF+R+++ N  YSC  + +C + K +R  C+ CR  
Sbjct: 104 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 163

Query: 119 KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 169
           KC + GM KE V         Q  + RI    S Y +  L         +++S  + +  
Sbjct: 164 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 223

Query: 170 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 225
             I    +  +    I ++  +C+    +L+V++ WAK+IP F  L L DQ++LL++   
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283

Query: 226 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 285
           E L+LG   RS+ F+D L+  +DYI+     +LA +  ++  IL +LV  ++ ++++  E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 342

Query: 286 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 345
           +  LKAI   + D+  + D   +++L+  +  +L+DY   +  +   R G++L+ LP L+
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402

Query: 346 SITWQMIEQIQFIKLFGMAKIDNLLQEML 374
             + + ++    IKL G   +  L  EML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431


>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
           sapiens]
          Length = 435

 Score =  178 bits (452), Expect = 8e-45
 Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)

Query: 59  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
           LC +CGD A+G HYG +SC+ CK FF+R+++ N  YSC  + +C + K +R  C+ CR  
Sbjct: 104 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 163

Query: 119 KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 169
           KC + GM KE V         Q  + RI    S Y +  L         +++S  + +  
Sbjct: 164 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 223

Query: 170 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 225
             I    +  +    I ++  +C+    +L+V++ WAK+IP F  L L DQ++LL++   
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283

Query: 226 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 285
           E L+LG   RS+ F+D L+  +DYI+     +LA +  ++  IL +LV  ++ ++++  E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 342

Query: 286 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 345
           +  LKAI   + D+  + D   +++L+  +  +L+DY   +  +   R G++L+ LP L+
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402

Query: 346 SITWQMIEQIQFIKLFGMAKIDNLLQEML 374
             + + ++    IKL G   +  L  EML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431


>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
           sapiens]
          Length = 458

 Score =  178 bits (452), Expect = 8e-45
 Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)

Query: 59  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
           LC +CGD A+G HYG +SC+ CK FF+R+++ N  YSC  + +C + K +R  C+ CR  
Sbjct: 127 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 186

Query: 119 KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 169
           KC + GM KE V         Q  + RI    S Y +  L         +++S  + +  
Sbjct: 187 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 246

Query: 170 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 225
             I    +  +    I ++  +C+    +L+V++ WAK+IP F  L L DQ++LL++   
Sbjct: 247 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 306

Query: 226 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 285
           E L+LG   RS+ F+D L+  +DYI+     +LA +  ++  IL +LV  ++ ++++  E
Sbjct: 307 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 365

Query: 286 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 345
           +  LKAI   + D+  + D   +++L+  +  +L+DY   +  +   R G++L+ LP L+
Sbjct: 366 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 425

Query: 346 SITWQMIEQIQFIKLFGMAKIDNLLQEML 374
             + + ++    IKL G   +  L  EML
Sbjct: 426 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 454


>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
           sapiens]
          Length = 435

 Score =  178 bits (452), Expect = 8e-45
 Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)

Query: 59  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
           LC +CGD A+G HYG +SC+ CK FF+R+++ N  YSC  + +C + K +R  C+ CR  
Sbjct: 104 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 163

Query: 119 KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 169
           KC + GM KE V         Q  + RI    S Y +  L         +++S  + +  
Sbjct: 164 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 223

Query: 170 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 225
             I    +  +    I ++  +C+    +L+V++ WAK+IP F  L L DQ++LL++   
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283

Query: 226 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 285
           E L+LG   RS+ F+D L+  +DYI+     +LA +  ++  IL +LV  ++ ++++  E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 342

Query: 286 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 345
           +  LKAI   + D+  + D   +++L+  +  +L+DY   +  +   R G++L+ LP L+
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402

Query: 346 SITWQMIEQIQFIKLFGMAKIDNLLQEML 374
             + + ++    IKL G   +  L  EML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431


>gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo
           sapiens]
          Length = 385

 Score =  177 bits (450), Expect = 1e-44
 Identities = 124/364 (34%), Positives = 178/364 (48%), Gaps = 50/364 (13%)

Query: 60  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQ--CVVDKDKRNQCRYCRL 117
           C +CGDR++GKHYG  +CDGC GFF+RS+R+N  Y C+   Q  C VDK  RNQCR CRL
Sbjct: 16  CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75

Query: 118 KKCFRAGMKKEAVQNER-DRISTRR-----------------SSYEDSSLPS---INALL 156
           KKC    M K+AVQ+ER  R ST R                 + +  ++LP+     A+ 
Sbjct: 76  KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135

Query: 157 QAE----VLSRQITSP---------------VSGINGDIRAKKIASIADVCESMKEQLLV 197
           Q E     L+   T+P                  +NG        +   VCES    L +
Sbjct: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195

Query: 198 LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM-VFKDVLLLGNDYIVPRHCP 256
            ++WAK +PAF  L L DQ+ LL     E  +LG  + ++ V  + LL  +         
Sbjct: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255

Query: 257 ELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFF-------DPDAKGLSDPGKIK 309
           +        I+ L E+V  F++L++D  E+A LK I+ F         + +   +   I 
Sbjct: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315

Query: 310 RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 369
            L+ + Q++L  YI+ R      RFG+LLLLLP L+SI+   IE++ F K  G   I  L
Sbjct: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375

Query: 370 LQEM 373
           L +M
Sbjct: 376 LSDM 379


>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
          Length = 448

 Score =  168 bits (425), Expect = 1e-41
 Identities = 111/374 (29%), Positives = 186/374 (49%), Gaps = 31/374 (8%)

Query: 35  TMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMY 94
           T   +  PS  + L  P    V   C +C D+++G HYG S+C+GCKGFFRRS++KN +Y
Sbjct: 59  TSSEELVPSPPSPLPPPR---VYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIY 115

Query: 95  SCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINA 154
           +C   + CV++K  RN+C+YCRL+KCF  GM KE+V+N+R++     S  E +    + A
Sbjct: 116 TCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTA 175

Query: 155 LLQ--AEVLSR----------QITSPVSGINGDIRAKKIASIADVCESMKEQLLV-LVEW 201
            L    E + +          Q+    +  + D R +    + D    +  + ++ +VE+
Sbjct: 176 ELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEF 235

Query: 202 AKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEM 261
           AK +P F  L + DQ+ LL+A   + L+L    R    +D +   +   + R      +M
Sbjct: 236 AKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR-----TQM 290

Query: 262 SRVSIRILDELVLPFQE----LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQV 317
                  L +LV  F      L++DD E   L AI     D + L +P K+ +L+  +  
Sbjct: 291 HNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLE 350

Query: 318 SLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG 377
           +L+ YI  R+      F ++L+ +  L+SI+ +  E++  +K+     +  L+QEML   
Sbjct: 351 ALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEML--- 407

Query: 378 SPSDAPHAHHPLHP 391
              +    H PL P
Sbjct: 408 ---ENSEGHEPLTP 418


>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
          Length = 423

 Score =  162 bits (409), Expect = 8e-40
 Identities = 102/346 (29%), Positives = 169/346 (48%), Gaps = 35/346 (10%)

Query: 59  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
           LC +CGD A+G HYG +SC+ CK FF+R+++ +  YSC  S +C + K +R  C+ CR  
Sbjct: 78  LCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFT 137

Query: 119 KCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL----------LQAEVLSRQITSP 168
           KC R GM KE V+   DR+   R  Y+    P ++ L          L      R+  +P
Sbjct: 138 KCLRVGMLKEGVR--LDRVRGGRQKYK--RRPEVDPLPFPGPFPAGPLAVAGGPRKTAAP 193

Query: 169 VSGINGDIRAKK----------------IASIADVCESMKEQLLVLVEWAKYIPAFCELP 212
           V+ +   +   +                + ++A +C+    +++V + WAK IP F  L 
Sbjct: 194 VNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLS 253

Query: 213 LDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDEL 272
           L DQ+++L++   E L+LG  +RS+  +D L    D ++       A +  +   +L +L
Sbjct: 254 LSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALL-QL 312

Query: 273 VLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRG 332
           V   Q L+++  EY  LKA+   + D+  + D   +++LR  +  +L +Y   R     G
Sbjct: 313 VRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGG 372

Query: 333 ----RFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 374
               R G LLL LP L+    +++     +KL G   +  L  EML
Sbjct: 373 AERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEML 418


>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  161 bits (407), Expect = 1e-39
 Identities = 97/332 (29%), Positives = 171/332 (51%), Gaps = 22/332 (6%)

Query: 60  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
           C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+C   + C+++K  RN+C+YCRL+K
Sbjct: 88  CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 147

Query: 120 CFRAGMKKEAVQNERDR----ISTRRSSYEDSSLPSINALLQAEVLSRQITSPV-----S 170
           CF  GM KE+V+N+R++    +     S   +  P +  L++    + Q T P       
Sbjct: 148 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 207

Query: 171 GINGDIRAKKIASIADVCESMKEQ----LLVLVEWAKYIPAFCELPLDDQVALLRAHAGE 226
               +   ++++   D+ +   E     ++  VE+AK +P F  L + DQ+ LL+A   +
Sbjct: 208 YTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 267

Query: 227 HLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE----LQID 282
            L+L    R    +D +   +   + R      +M       L +LV  F      L++D
Sbjct: 268 ILILRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFANQLLPLEMD 322

Query: 283 DNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLP 342
           D E   L AI     D + L  P ++  L+  +  +L+ Y+  R+      F ++L+ + 
Sbjct: 323 DAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT 382

Query: 343 TLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 374
            L+SI+ +  E++  +K+     +  L+QEML
Sbjct: 383 DLRSISAKGAERVITLKMEIPGSMPPLIQEML 414


>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
          Length = 457

 Score =  161 bits (407), Expect = 1e-39
 Identities = 97/332 (29%), Positives = 171/332 (51%), Gaps = 22/332 (6%)

Query: 60  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
           C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+C   + C+++K  RN+C+YCRL+K
Sbjct: 83  CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 142

Query: 120 CFRAGMKKEAVQNERDR----ISTRRSSYEDSSLPSINALLQAEVLSRQITSPV-----S 170
           CF  GM KE+V+N+R++    +     S   +  P +  L++    + Q T P       
Sbjct: 143 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 202

Query: 171 GINGDIRAKKIASIADVCESMKEQ----LLVLVEWAKYIPAFCELPLDDQVALLRAHAGE 226
               +   ++++   D+ +   E     ++  VE+AK +P F  L + DQ+ LL+A   +
Sbjct: 203 YTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 262

Query: 227 HLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE----LQID 282
            L+L    R    +D +   +   + R      +M       L +LV  F      L++D
Sbjct: 263 ILILRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFANQLLPLEMD 317

Query: 283 DNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLP 342
           D E   L AI     D + L  P ++  L+  +  +L+ Y+  R+      F ++L+ + 
Sbjct: 318 DAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT 377

Query: 343 TLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 374
            L+SI+ +  E++  +K+     +  L+QEML
Sbjct: 378 DLRSISAKGAERVITLKMEIPGSMPPLIQEML 409


>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  161 bits (407), Expect = 1e-39
 Identities = 97/332 (29%), Positives = 171/332 (51%), Gaps = 22/332 (6%)

Query: 60  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
           C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+C   + C+++K  RN+C+YCRL+K
Sbjct: 88  CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 147

Query: 120 CFRAGMKKEAVQNERDR----ISTRRSSYEDSSLPSINALLQAEVLSRQITSPV-----S 170
           CF  GM KE+V+N+R++    +     S   +  P +  L++    + Q T P       
Sbjct: 148 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 207

Query: 171 GINGDIRAKKIASIADVCESMKEQ----LLVLVEWAKYIPAFCELPLDDQVALLRAHAGE 226
               +   ++++   D+ +   E     ++  VE+AK +P F  L + DQ+ LL+A   +
Sbjct: 208 YTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 267

Query: 227 HLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE----LQID 282
            L+L    R    +D +   +   + R      +M       L +LV  F      L++D
Sbjct: 268 ILILRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFANQLLPLEMD 322

Query: 283 DNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLP 342
           D E   L AI     D + L  P ++  L+  +  +L+ Y+  R+      F ++L+ + 
Sbjct: 323 DAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT 382

Query: 343 TLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 374
            L+SI+ +  E++  +K+     +  L+QEML
Sbjct: 383 DLRSISAKGAERVITLKMEIPGSMPPLIQEML 414


>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
          Length = 454

 Score =  161 bits (407), Expect = 1e-39
 Identities = 110/389 (28%), Positives = 185/389 (47%), Gaps = 26/389 (6%)

Query: 27  EFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRR 86
           E  ++ V T    +     ++ + P    V   C +C D+++G HYG SSC+GCKGFFRR
Sbjct: 57  EMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRR 116

Query: 87  SVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTR------ 140
           S++KN +Y+C   + C+++K  RN+C+YCRL+KCF  GM KEAV+N+R++          
Sbjct: 117 SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGS 176

Query: 141 RSSYEDSSLPSINALLQAEVLSRQITSP--------VSGINGDIRAKKIASIADVCESMK 192
             SYE S  P +  L+     + Q T P         +  + D R +    + D    + 
Sbjct: 177 PDSYELS--PQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELA 234

Query: 193 EQLLV-LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIV 251
            + ++ +VE+AK +P F  L + DQ+ LL+A   + L+L    R    +D +   +   +
Sbjct: 235 TKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTL 294

Query: 252 PRHCPELAEMSRVSIRILDELVLPFQ----ELQIDDNEYAYLKAIIFFDPDAKGLSDPGK 307
            R      +M       L +LV  F      L++DD E   L AI     D   L +P K
Sbjct: 295 NR-----TQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEK 349

Query: 308 IKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKID 367
           + +L+  +  +L  Y   R+      F  +L+ +  L+ I+ +  E+   +K+     + 
Sbjct: 350 VDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMP 409

Query: 368 NLLQEMLLGGSPSDAPHAHHPLHPHLMQE 396
            L++EML      +   +    HP+   E
Sbjct: 410 PLIREMLENPEMFEDDSSQPGPHPNASSE 438


>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
          Length = 443

 Score =  160 bits (404), Expect = 3e-39
 Identities = 105/356 (29%), Positives = 174/356 (48%), Gaps = 26/356 (7%)

Query: 60  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
           C +C D+++G HYG SSC+GCKGFFRRS++KN +Y+C   + C+++K  RN+C+YCRL+K
Sbjct: 79  CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 138

Query: 120 CFRAGMKKEAVQNERDRISTR------RSSYEDSSLPSINALLQAEVLSRQITSP----- 168
           CF  GM KEAV+N+R++            SYE S  P +  L+     + Q T P     
Sbjct: 139 CFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELS--PQLEELITKVSKAHQETFPSLCQL 196

Query: 169 ---VSGINGDIRAKKIASIADVCESMKEQLLV-LVEWAKYIPAFCELPLDDQVALLRAHA 224
               +  + D R +    + D    +  + ++ +VE+AK +P F  L + DQ+ LL+A  
Sbjct: 197 GKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAAC 256

Query: 225 GEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQ----ELQ 280
            + L+L    R    +D +   +   + R      +M       L +LV  F      L+
Sbjct: 257 LDILMLRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFAGQLLPLE 311

Query: 281 IDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLL 340
           +DD E   L AI     D   L +P K+ +L+  +  +L  Y   R+      F  +L+ 
Sbjct: 312 MDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMK 371

Query: 341 LPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQE 396
           +  L+ I+ +  E+   +K+     +  L++EML      +   +    HP+   E
Sbjct: 372 ITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSE 427


>gi|7706515 photoreceptor-specific nuclear receptor isoform a [Homo
           sapiens]
          Length = 367

 Score =  155 bits (392), Expect = 8e-38
 Identities = 104/319 (32%), Positives = 151/319 (47%), Gaps = 47/319 (14%)

Query: 51  PNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF-SRQCVVDKDKR 109
           P  +  S  C +CGD ++GKHYG  +C+GC GFF+RSVR+  +Y C+  +  C VDK  R
Sbjct: 38  PTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHR 97

Query: 110 NQCRYCRLKKCFRAGMKKEAVQNERDRISTRR------SSYEDSSLPSINALLQAEVLSR 163
           NQC+ CRLKKC +AGM ++AVQNER   ST +       S  +S   S+ A       S 
Sbjct: 98  NQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSP 157

Query: 164 QITSPVSG------------INGDIRAKKIASIAD------------------------- 186
           +  +P+S             I  +  AK     AD                         
Sbjct: 158 RGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGL 217

Query: 187 --VCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDV-L 243
             + E+    L + V+WAK +P F  LP  DQV LL     E  LLGA + S+      L
Sbjct: 218 DSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPL 277

Query: 244 LLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS 303
           L   +            ++ +  R+L E +  F+ L +D  E+A +KA++ F P+ +GL 
Sbjct: 278 LAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLK 337

Query: 304 DPGKIKRLRSQVQVSLEDY 322
           DP  ++ L+ Q QV L  +
Sbjct: 338 DPEHVEALQDQSQVMLSQH 356


>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
           sapiens]
          Length = 598

 Score =  145 bits (366), Expect = 8e-35
 Identities = 106/370 (28%), Positives = 183/370 (49%), Gaps = 36/370 (9%)

Query: 32  QVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKN 91
           Q+L     + PS G+  N         LCA+CGD A  +HYG  +C+GCKGFF+R+V+KN
Sbjct: 242 QLLDTQVPSPPSRGSPSN-------EGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKN 294

Query: 92  HMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNE-----RDRISTRRSSYED 146
             Y C  ++ C VDK +RN+C+YCR +KC   GM KE V+ +     R R+ ++  S ++
Sbjct: 295 AKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQE 354

Query: 147 SSLPS-----INALLQAEV----------LSRQITSPVSGINGDIRAKKIASIADVCESM 191
            S PS     I+AL++A V           SR   +P   ++GD   + I    D+    
Sbjct: 355 PSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGD-DTQHIQQFYDLLTGS 413

Query: 192 KEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIV 251
            E   ++  WA+ IP F +LP  DQ  L  +   E  +L    RS   +  L+  N  ++
Sbjct: 414 ME---IIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVL 470

Query: 252 PRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRL 311
             H  +        I  + E     Q + ID + ++ + A+     +  GL +P +++ L
Sbjct: 471 --HRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMV-TERHGLKEPKRVEEL 527

Query: 312 RSQVQVSLEDYI--NDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 369
           ++++   L+D++  N+   +      +LL  LP L+++  Q +++I ++KL  +     +
Sbjct: 528 QNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAI 587

Query: 370 LQEMLLGGSP 379
           + ++ L   P
Sbjct: 588 IDKLFLDTLP 597


>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  144 bits (364), Expect = 1e-34
 Identities = 99/335 (29%), Positives = 158/335 (47%), Gaps = 39/335 (11%)

Query: 51  PNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKN--HMYSCRFSRQCVVDKDK 108
           P+ L    LC +CGD+ATG HY   +C+GCKGFFRR+++KN    YSC++  +CV+DK  
Sbjct: 98  PSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVT 157

Query: 109 RNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA---------- 158
           RNQC+ CR KKC   GM  + V ++  R++ R+   E+        L ++          
Sbjct: 158 RNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDE 217

Query: 159 ------EVLSRQITSPVSGINGDIRAKKI------ASIADVCESMKEQLLV--------- 197
                  V    + +   G +   + K +      A I +  E  K  L           
Sbjct: 218 EWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIIT 277

Query: 198 -----LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVP 252
                +V++AK +P FCELP +DQ+ LL+    E + L A  R     + L L  +  V 
Sbjct: 278 PAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVT 337

Query: 253 RHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLR 312
           R   +   +  VS  I D L +      +DD E A L+A++    D  GL+   +I++ +
Sbjct: 338 RGQLKNGGLGVVSDAIFD-LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQ 396

Query: 313 SQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 347
               ++ E YIN R++     + +LL+ +  L+ I
Sbjct: 397 DSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMI 431


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,044,410
Number of Sequences: 37866
Number of extensions: 943093
Number of successful extensions: 5310
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 121
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 4883
Number of HSP's gapped (non-prelim): 345
length of query: 474
length of database: 18,247,518
effective HSP length: 106
effective length of query: 368
effective length of database: 14,233,722
effective search space: 5238009696
effective search space used: 5238009696
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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