Guide to the Human Genome
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Search of human proteins with 29789445

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|29789445 desmoglein 4 isoform 2 [Homo sapiens]
         (1040 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|29789445 desmoglein 4 isoform 2 [Homo sapiens]                    2106   0.0  
gi|197313787 desmoglein 4 isoform 1 [Homo sapiens]                   2053   0.0  
gi|119964718 desmoglein 3 preproprotein [Homo sapiens]                953   0.0  
gi|116534898 desmoglein 2 preproprotein [Homo sapiens]                610   e-174
gi|119703744 desmoglein 1 preproprotein [Homo sapiens]                605   e-173
gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo sapi...   365   e-100
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap...   351   2e-96
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi...   342   8e-94
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi...   323   7e-88
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]           323   7e-88
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]           317   5e-86
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap...   310   5e-84
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]   303   7e-82
gi|4826669 cadherin 15 preproprotein [Homo sapiens]                   301   2e-81
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]            295   1e-79
gi|4502719 cadherin 13 preproprotein [Homo sapiens]                   278   1e-74
gi|29570800 cadherin-like 26 isoform a [Homo sapiens]                 272   1e-72
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]           266   1e-70
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]            195   2e-49
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]           194   3e-49
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]           194   3e-49
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]          194   4e-49
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]           189   9e-48
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]          184   5e-46
gi|16753221 cadherin 22 precursor [Homo sapiens]                      179   1e-44
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]          176   1e-43
gi|221316595 cadherin 17 precursor [Homo sapiens]                     176   1e-43
gi|221316593 cadherin 17 precursor [Homo sapiens]                     176   1e-43
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]           174   3e-43
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]          174   5e-43

>gi|29789445 desmoglein 4 isoform 2 [Homo sapiens]
          Length = 1040

 Score = 2106 bits (5456), Expect = 0.0
 Identities = 1040/1040 (100%), Positives = 1040/1040 (100%)

Query: 1    MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE 60
            MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE
Sbjct: 1    MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE 60

Query: 61   GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT 120
            GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT
Sbjct: 61   GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT 120

Query: 121  PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC 180
            PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC
Sbjct: 121  PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC 180

Query: 181  ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS 240
            ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS
Sbjct: 181  ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS 240

Query: 241  DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT 300
            DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT
Sbjct: 241  DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT 300

Query: 301  DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS 360
            DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS
Sbjct: 301  DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS 360

Query: 361  VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN 420
            VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN
Sbjct: 361  VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN 420

Query: 421  PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT 480
            PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT
Sbjct: 421  PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT 480

Query: 481  GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD 540
            GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD
Sbjct: 481  GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD 540

Query: 541  VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA 600
            VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA
Sbjct: 541  VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA 600

Query: 601  AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP 660
            AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP
Sbjct: 601  AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP 660

Query: 661  EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVSNICAPMTASNTQDRMDSSEIYTNTYA 720
            EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVSNICAPMTASNTQDRMDSSEIYTNTYA
Sbjct: 661  EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVSNICAPMTASNTQDRMDSSEIYTNTYA 720

Query: 721  AGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLD 780
            AGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLD
Sbjct: 721  AGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLD 780

Query: 781  SYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKF 840
            SYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKF
Sbjct: 781  SYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKF 840

Query: 841  RTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESSGLTPSEVEFQEEMAASEPV 900
            RTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESSGLTPSEVEFQEEMAASEPV
Sbjct: 841  RTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESSGLTPSEVEFQEEMAASEPV 900

Query: 901  VHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYN 960
            VHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYN
Sbjct: 901  VHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYN 960

Query: 961  NVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDLPIGQTVGST 1020
            NVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDLPIGQTVGST
Sbjct: 961  NVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDLPIGQTVGST 1020

Query: 1021 SPMTSRHRVTRYSNIHYTQQ 1040
            SPMTSRHRVTRYSNIHYTQQ
Sbjct: 1021 SPMTSRHRVTRYSNIHYTQQ 1040


>gi|197313787 desmoglein 4 isoform 1 [Homo sapiens]
          Length = 1059

 Score = 2053 bits (5319), Expect = 0.0
 Identities = 1023/1059 (96%), Positives = 1024/1059 (96%), Gaps = 19/1059 (1%)

Query: 1    MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE 60
            MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE
Sbjct: 1    MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE 60

Query: 61   GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT 120
            GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT
Sbjct: 61   GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT 120

Query: 121  PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC 180
            PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC
Sbjct: 121  PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC 180

Query: 181  ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS 240
            ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS
Sbjct: 181  ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS 240

Query: 241  DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT 300
            DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT
Sbjct: 241  DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT 300

Query: 301  DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS 360
            DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS
Sbjct: 301  DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS 360

Query: 361  VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN 420
            VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN
Sbjct: 361  VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN 420

Query: 421  PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT 480
            PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT
Sbjct: 421  PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT 480

Query: 481  GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD 540
            GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD
Sbjct: 481  GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD 540

Query: 541  VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA 600
            VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA
Sbjct: 541  VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA 600

Query: 601  AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP 660
            AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP
Sbjct: 601  AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP 660

Query: 661  EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVSNICAP-------------------MT 701
            EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDR  S    P                    T
Sbjct: 661  EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRLFSAYALPGGGGTADGGGSVLGRCALQAT 720

Query: 702  ASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSS 761
             +        SEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSS
Sbjct: 721  PALLNQHPPFSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSS 780

Query: 762  TMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCC 821
            TMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCC
Sbjct: 781  TMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCC 840

Query: 822  SWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESS 881
            SWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESS
Sbjct: 841  SWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESS 900

Query: 882  GLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMA 941
            GLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMA
Sbjct: 901  GLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMA 960

Query: 942  PVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEI 1001
            PVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEI
Sbjct: 961  PVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEI 1020

Query: 1002 QVMQMMSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQQ 1040
            QVMQMMSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQQ
Sbjct: 1021 QVMQMMSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQQ 1059


>gi|119964718 desmoglein 3 preproprotein [Homo sapiens]
          Length = 999

 Score =  953 bits (2464), Expect = 0.0
 Identities = 504/1005 (50%), Positives = 674/1005 (67%), Gaps = 58/1005 (5%)

Query: 4   LFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACREGED 63
           LF R    L I +VV+ V+ E  +E K    E   T  Q  RRQKREW+KFA  CREGED
Sbjct: 4   LFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGED 63

Query: 64  NSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREITPLF 123
           NSKRNPIAKI SD ++ QKITYRISGVGID+PP+G+F ++  TG+INIT++VDRE TP F
Sbjct: 64  NSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSF 123

Query: 124 LIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLCATD 183
           LI CRALN++G D+E+PL L VK++DINDN PVFSQ ++   IEENS +N+LV+ L ATD
Sbjct: 124 LITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATD 183

Query: 184 ADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRD 243
           ADE NHLNSKIA+KIVSQEP+G PMF+L+R TGEV T+++ LDREQ S Y LVV G+D+D
Sbjct: 184 ADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKD 243

Query: 244 GAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNW 303
           G  +GLS++C+C IKV DVNDNFP    + YSA IEEN LSSEL+R Q  DLDEE TDNW
Sbjct: 244 G--EGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNW 301

Query: 304 LAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSVAS 363
           LA Y   SGN+GNWF+IQTDP+TNEGILKVVK LDYEQ  +++LSI VKN+A+FH SV S
Sbjct: 302 LAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVIS 361

Query: 364 QFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPAT 423
           ++++  TPV IQV++VREG AF P++  F+V++GI    L++Y+LGTY AID DT   A+
Sbjct: 362 RYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAAS 421

Query: 424 DVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTATGTI 483
           +V+Y++G + G +L IDS+T EI+F +  ++ S +I+N   TAE+LAID+ +GKT+TGT+
Sbjct: 422 NVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTV 481

Query: 484 CIEVPDINDYCPNIFPERRTICIDSPSVLISVN--EHSYGSPFTFCVVDEPPGIADMWDV 541
            + VPD ND CP    E+  +C  SPSV++S     + Y  P+TF + D+P  +  +W +
Sbjct: 482 YVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSI 541

Query: 542 RSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAA 601
            + NATSA+L A++ + PG Y I +++ DS N  CE+ + + L  C CD+  +C  S   
Sbjct: 542 TTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTS--- 598

Query: 602 GIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPE 661
             Y     G  YG     +       LGPA IG+++LG+LLL+LAPLLLL C C      
Sbjct: 599 --YPTTSPGTRYGRPHSGR-------LGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTG 649

Query: 662 GLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVSNICAPMTASNTQDRMDSSEIYTNTYAA 721
           G+   F PVP+G EG +  W IEGAHPED++++NIC P   +N  D M+SSE+ TNTYA 
Sbjct: 650 GVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYAR 709

Query: 722 GGTVEGGVSGVELNTGMGTA-------------VGLMAAG----------AAGASGAARK 758
           G  VE G SG+E+ T +G A             V   A+G          ++G SG  R 
Sbjct: 710 GTAVE-GTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRT 768

Query: 759 RSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEG---VGSPV 815
           R ST GT +DYAD  I+M FLDSYFS+KA+A A+ED+G+ ANDCLLIYD+EG    GSPV
Sbjct: 769 RHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPV 828

Query: 816 GSIGCCSWIVDDLDESCMETLDPKFRTLAEICLNT-----EIEPFPSHQACIPI-STDLP 869
           GS+GCCS+I DDLD+S +++L PKF+ LAEI L       E++P PS  +   I S   P
Sbjct: 829 GSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVDGEGKEVQP-PSKDSGYGIESCGHP 887

Query: 870 L-LGPNYFV-------NESSGLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPT 921
           + +    FV       ++ +    +    Q  ++  +P+ HG+ +VTETY  +   VQP+
Sbjct: 888 IEVQQTGFVKCQTLSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPS 947

Query: 922 TIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYNNVIYAE 966
           T  FDP L  NV+VTE V+ P+  + GN+  P +L   + ++  E
Sbjct: 948 TAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTMLCTE 992


>gi|116534898 desmoglein 2 preproprotein [Homo sapiens]
          Length = 1118

 Score =  610 bits (1572), Expect = e-174
 Identities = 388/1023 (37%), Positives = 558/1023 (54%), Gaps = 98/1023 (9%)

Query: 12  LIILMVVMEVNSEFIVEVKEFDIENGTT-KWQTVRRQKREWIKFAAACREGEDNSKRNPI 70
           L++L++   V S   ++V     EN    K   + RQKR WI    A REGED SK+NPI
Sbjct: 11  LLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPI 70

Query: 71  AKIRSDC--ESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREITPLFLIYCR 128
           AKI SD   E   KITY+ +G GI  PP+G+F  N  TGE+N+TS++DRE TP FL+   
Sbjct: 71  AKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGY 130

Query: 129 ALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLCATDADEEN 188
           AL++RG ++E+PLELR+KV+DINDN PVF+Q V+  S+EE S A+TLV+K+ ATDADE N
Sbjct: 131 ALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPN 190

Query: 189 HLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDG-AAD 247
            LNSKI+Y+IVS EP+  P+F LN+ TGE+ T S  LDRE+HS Y L V   D +G   D
Sbjct: 191 TLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTD 250

Query: 248 GLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNWLAQY 307
               +   +I++LDVNDN P +E       +EEN ++ E+ R++  D DE G+DNWLA +
Sbjct: 251 KPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANF 310

Query: 308 LILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSVASQFQM 367
              SGN+G +F I+TD QTNEGI+ ++K +DYE+  N+  S+ V N+A FH S+ S+++ 
Sbjct: 311 TFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKP 370

Query: 368 HPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRY 427
            P P++++V +V+EG  F  S ++  V E +  SS    ++G + A D DTG PA   RY
Sbjct: 371 TPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSS-KGQIIGNFQAFDEDTGLPA-HARY 428

Query: 428 IIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAI-DDGSGKTATGTICIE 486
           +   D  +W+ +DS T EI+ ++  D +S+Y+ NG YT +I+AI +D   KT TGT+ I 
Sbjct: 429 VKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLIN 488

Query: 487 VPDINDYCPNIFPERRTICIDSPSVLISVNE---HSYGSPFTFCVVDEPPGIADMWDVRS 543
           V DIND CP +    +TIC D+  V ++  +   H    PF+F V+D+PPG+A+ W +  
Sbjct: 489 VEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIAR 548

Query: 544 TNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGI 603
             +TS +L   +    G  EI  L+ D+   +C   Q++ L  C+C     C        
Sbjct: 549 QESTSVLLQQSE-KKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGC-------- 599

Query: 604 YTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGL 663
              +   D+Y            VGLGPA I +M+L  LLL+L PLLLL+C C      G 
Sbjct: 600 --REAQHDSY------------VGLGPAAIALMILAFLLLLLVPLLLLMCHC------GK 639

Query: 664 GTR-FAPVPEGGEGVMQSWRIEGAHPEDRDVSNICAPMTASNTQDRMD----SSEIYTNT 718
           G + F P+P G   ++  W  EGA PED+ V +        +   R      + E     
Sbjct: 640 GAKGFTPIP-GTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKG 698

Query: 719 YAAGGTVEGGVSGVELNTGMGTAVGLMAAGA---AGASGA-----ARKRSSTMGTLRDYA 770
            ++   V+G     E++        L++  A    GA+GA       K +   G  RD A
Sbjct: 699 SSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMA 758

Query: 771 DAD-----INMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIV 825
            A      +N  FL +YF++KA +Y +EDE   A DCLL+Y  E   S   SIGCCS+I 
Sbjct: 759 GAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIE 818

Query: 826 DDLDESCMETLDPKFRTLAEICL------NTEIEP-----------FPSHQAC---IPIS 865
            +LD+  ++ L  KF+TLAE+CL      N EIE              SH  C   +  S
Sbjct: 819 GELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNS 878

Query: 866 TDLPLLGPNYFVNESSGLTPSEVEFQE---EMAAS------------EPVVHGDIIVTET 910
            +    G ++ V +S     +E   QE   E + S            +P+   ++I TET
Sbjct: 879 ENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATET 938

Query: 911 YGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYNNVIYAERVLA 970
                  + PTT+I  P    +++VTE V AP      +  V    A+   V+  ERV+ 
Sbjct: 939 SYVTGSTMPPTTVILGPSQPQSLIVTERVYAP-----ASTLVDQPYANEGTVVVTERVIQ 993

Query: 971 SPG 973
             G
Sbjct: 994 PHG 996



 Score = 33.9 bits (76), Expect = 0.82
 Identities = 31/122 (25%), Positives = 52/122 (42%), Gaps = 35/122 (28%)

Query: 918  VQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYNNVIYAERVLASPGVPDM 977
            VQPT  + +  +  NV VTE V+AP   +Q +  +P E    N++      ++  GVP  
Sbjct: 1029 VQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTE----NSMTARNTTVSGAGVP-- 1082

Query: 978  SNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDLPIGQTVGSTSPM-TSRHRVTRYSNIH 1036
                      GP+                  PD  + ++  S S + TS  RVT++S + 
Sbjct: 1083 ----------GPL------------------PDFGLEESGHSNSTITTSSTRVTKHSTVQ 1114

Query: 1037 YT 1038
            ++
Sbjct: 1115 HS 1116


>gi|119703744 desmoglein 1 preproprotein [Homo sapiens]
          Length = 1049

 Score =  605 bits (1560), Expect = e-173
 Identities = 291/503 (57%), Positives = 385/503 (76%), Gaps = 5/503 (0%)

Query: 1   MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE 60
           MDW FFR + +L I +VV+EVNSEF ++V++++ +NGT KW ++RRQKREWIKFAAACRE
Sbjct: 1   MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACRE 60

Query: 61  GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT 120
           GEDNSKRNPIAKI SDC +NQ++TYRISGVGID+PPYG+F IN +TGEINITS+VDRE+T
Sbjct: 61  GEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVT 120

Query: 121 PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC 180
           P F+IYCRALNS G+DLERPLELRV+V+DINDN PVFS + +   IEENS+ANTLV+ L 
Sbjct: 121 PFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILN 180

Query: 181 ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS 240
           ATDADE N+LNSKIA+KI+ QEPS +PMFI+NR TGE+ TM++FLDREQ+  Y L VRGS
Sbjct: 181 ATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGS 240

Query: 241 DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT 300
           DRDG ADG+S+EC+C IK+LDVNDN P +E++SY+  I+EN L+S L+ ++ IDLDEE +
Sbjct: 241 DRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFS 300

Query: 301 DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS 360
            NW+A    +SGN+GNWF+I+ + +TN GILKVVK LDYE   ++QLSIGV+N+A+FH+S
Sbjct: 301 ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS 360

Query: 361 VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN 420
           + SQ+++  + + + V++V EGP F P +  + V  G  GS   N  +G + A DLDTG 
Sbjct: 361 IMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVV-TGNMGS---NDKVGDFVATDLDTGR 416

Query: 421 PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT 480
           P+T VRY++G++    L +DSRTG++    +  K+   ++ G Y   IL+IDD   +T T
Sbjct: 417 PSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCT 476

Query: 481 GTICIEVPDI-NDYCPNIFPERR 502
           GTI I +    ND   N  P  +
Sbjct: 477 GTININIQSFGNDDRTNTEPNTK 499



 Score =  278 bits (712), Expect = 1e-74
 Identities = 280/1006 (27%), Positives = 445/1006 (44%), Gaps = 193/1006 (19%)

Query: 191  NSKIAYKI----VSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDGAA 246
            N ++ Y+I    + Q P G  +F++N+ TGE+  ++S +DRE    + +  R  +  G  
Sbjct: 80   NQQVTYRISGVGIDQPPYG--IFVINQKTGEI-NITSIVDREVTPFFIIYCRALNSMG-- 134

Query: 247  DGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIR-LQAIDLDEEGTDNWLA 305
              L    + R++VLD+NDN P     +++  IEEN  ++ L+  L A D DE    N   
Sbjct: 135  QDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKI 194

Query: 306  QYLIL--SGNDGNWFDIQTDPQTNEGILKVVK-MLDYEQAPNIQLSIGVKNQADFHYSVA 362
             + I+    +D   F I      N G ++ +   LD EQ     L++   ++      ++
Sbjct: 195  AFKIIRQEPSDSPMFIINR----NTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMS 250

Query: 363  SQFQMHPTPVRIQVVDVREG-PAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNP 421
            ++ + +     I+++DV +  P    S+    ++E    S+LL         IDLD    
Sbjct: 251  AECECN-----IKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEI-----RVIDLDEEFS 300

Query: 422  AT--DVRYIIGHDAGSW--LKIDSRT--GEIQFSREFDKKSKYIIN---GIYT-AEILAI 471
            A    V + I  + G+W  ++++ RT  G ++  +  D ++   +    G+   AE    
Sbjct: 301  ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS 360

Query: 472  DDGSGKTATGTICIEVPDINDYCPNIFPERRTICI-------DSPSVLISVNEHSYGSPF 524
                 K     I + V ++ +  P   P  +T  +       D     ++ +  + G P 
Sbjct: 361  IMSQYKLKASAISVTVLNVIEG-PVFRPGSKTYVVTGNMGSNDKVGDFVATDLDT-GRPS 418

Query: 525  TFC--VVDEPPGIADMWDVRSTNATSAILTAKQVLSP-------GFYEIPIL-VKDSYNR 574
            T    V+   P      D+ + ++ +  LT K  ++        G Y+  IL + D+  R
Sbjct: 419  TTVRYVMGNNPA-----DLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQR 473

Query: 575  ACELAQMVQLYACDCDD------------NHMCLDSGAAGIYTEDITGDTYGPVTEDQAG 622
             C     + + +   DD            N    +S ++  Y    T      V   + G
Sbjct: 474  TCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPG 533

Query: 623  -------VSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGE 675
                     NV  GPAGIG++++G L+L L P L++ C C        G  F PVPE  +
Sbjct: 534  NGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAG--FEPVPECSD 591

Query: 676  GVMQSWRIEGAHPEDRDVSNICA--PMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVE 733
            G + SW +EG  PE RD++ +    P   +N  + +D+S +YTN Y  GG     + G E
Sbjct: 592  GAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEY--GGREMQDLGGGE 649

Query: 734  LNTGMGTAVGLMAAGAAGA----SGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYA 789
              TG     G+  +G        SG  R+ S     +R+  +  +NM F++SYF +KAYA
Sbjct: 650  RMTGFELTEGVKTSGMPEICQEYSGTLRRNS-----MRECREGGLNMNFMESYFCQKAYA 704

Query: 790  YADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICLN 849
            YADEDEGRP+NDCLLIYD EGVGSP GS+GCCS+I +DLD+S ++TL PKF+ LA+I L 
Sbjct: 705  YADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLG 764

Query: 850  TEIEP-----FP---SHQACIPISTD---------------------------------L 868
             E  P     +P   +   C+P  T+                                  
Sbjct: 765  KESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPK 824

Query: 869  PLLGP----NYFVNES----SGLTPSEVEFQEEMAASEPVV-------------HG---- 903
            P+L P    N  V ES      L PS V   +   AS  VV             HG    
Sbjct: 825  PILDPLGYGNVTVTESYTTSDTLKPS-VHVHDNRPASNVVVTERVVGPISGADLHGMLEM 883

Query: 904  -------DIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAEL 956
                   ++IVTE        +  +  I  P+ + NVVVTE V+ P   + G++ +  EL
Sbjct: 884  PDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPEL 943

Query: 957  ADYNNVIYAERVLASPGVPDMSNSSTTEGCMGP-------------VMSGNILVGPEIQV 1003
            A+ +NVI  ERV++  GV  +S ++   G +G               +SG  + G  I +
Sbjct: 944  ANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGL 1003

Query: 1004 MQM----------MSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQ 1039
              +           S D    QT+GS SP T+R R+T+YS + Y++
Sbjct: 1004 SSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQYSK 1049


>gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo
           sapiens]
          Length = 901

 Score =  365 bits (936), Expect = e-100
 Identities = 257/827 (31%), Positives = 388/827 (46%), Gaps = 69/827 (8%)

Query: 39  TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98
           TK + +RR KR W     +  E         + +++SD   N  I Y I G G+D+ P  
Sbjct: 125 TKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRN 184

Query: 99  VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
           +F +   TG +  T  VDRE    F I   A    G   E PL L +K+ D NDN P+F+
Sbjct: 185 LFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFT 244

Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218
           +  YT +I EN    T V ++CATD DE + +++++ Y I+ Q P    +F ++  TG +
Sbjct: 245 EETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVI 304

Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
            T SS LDRE    Y L ++  D DG   GL +   C I + DVND+ PT  +TSY  S+
Sbjct: 305 TTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSV 364

Query: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338
           EEN +  E++R+   D D   T NW A Y IL GN+   F I TD +TNEG+L VVK L+
Sbjct: 365 EENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLN 424

Query: 339 YEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
           YE+   + L IGV N+A F    + +  M    V + V D  EGP  +P      ++E  
Sbjct: 425 YEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENA 484

Query: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKY 458
           +  +  N     Y A D +T   ++ +RY    D   W+ ID  TG I+  R  D++++ 
Sbjct: 485 EVGTTSN----GYKAYDPET-RSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAET 539

Query: 459 IINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSPS------VL 512
           I NGIY   +LA D G G+T TGT+ I + D+ND  P  F  ++T+ I  P+      V 
Sbjct: 540 IKNGIYNITVLASDQG-GRTCTGTLGIILQDVNDNSP--FIPKKTVIICKPTMSSAEIVA 596

Query: 513 ISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSY 572
           +  +E  +G PF F +      +  MW +++ N T+A L+ +     G Y +PI V+D  
Sbjct: 597 VDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRL 656

Query: 573 NRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAG 632
             +   +  V L  CDC   + C                      + + G   V LG   
Sbjct: 657 GMSSVTSLDVTL--CDCITENDCTHR------------------VDPRIGGGGVQLGKWA 696

Query: 633 IGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRD 692
           I  ++LGI LL    +L  L C                  G  G  +  ++    P+D  
Sbjct: 697 ILAILLGIALLFC--ILFTLVC------------------GASGTSKQPKV---IPDDLA 733

Query: 693 VSNICAPMTASNTQDRMDSSEIYTNTYAAGGTVEG--GVSGVELNTGMGTAVGLMAAG-- 748
             N+    T +   D++ S+  +T T   G + +G  G  G  +  G    + ++  G  
Sbjct: 734 QQNLIVSNTEAPGDDKVYSANGFT-TQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQ 792

Query: 749 ---AAGASGAARKRSSTMGTLRDYADADINM----AFLDSYFSEKAYAYADEDEGRPAND 801
              +   +G      S  G   +  +         +F      EK Y    ++  + A D
Sbjct: 793 TSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKVYLCNQDENHKHAQD 852

Query: 802 CLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICL 848
            +L Y++EG GS  GS+GCCS   ++     ++ L+PKFRTLAE C+
Sbjct: 853 YVLTYNYEGRGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAEACM 899


>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
           sapiens]
          Length = 896

 Score =  351 bits (901), Expect = 2e-96
 Identities = 248/825 (30%), Positives = 388/825 (47%), Gaps = 72/825 (8%)

Query: 39  TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98
           T+   +RR KR W     + +E         + ++ SD   N  + Y ISG G+D+ P  
Sbjct: 125 TRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLN 184

Query: 99  VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
           +F I   TG +  T  VDRE   +F +   A  + G   + PL L ++V D NDN PVF+
Sbjct: 185 LFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFT 244

Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218
           +++Y   + E+S   T V  +CATD DE + +++++ Y I+ Q P    +F ++  TG +
Sbjct: 245 EAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVI 304

Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
            T+S +LDRE    Y+L+++  D DG   GL     C I V D NDN PT  + +Y A +
Sbjct: 305 TTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFV 364

Query: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338
           EEN  + E++R+   D D   T NW   + IL GN+   F I TD +TNEG+L VVK L+
Sbjct: 365 EENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLN 424

Query: 339 YEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
           YE+   + L IGV N+A F   +     ++   V + V D+ EGP   P+     ++E +
Sbjct: 425 YEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENL 484

Query: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKY 458
              S +N     Y A D +  N    +RY   HD   W+ ID  +G I  S+  D++ + 
Sbjct: 485 AVGSKIN----GYKAYDPENRN-GNGLRYKKLHDPKGWITIDEISGSIITSKILDREVET 539

Query: 459 IINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICID----SPSVLIS 514
             N +Y   +LAID    ++ TGT+ + + D+ND  P I  E   IC      +  + + 
Sbjct: 540 PKNELYNITVLAIDK-DDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVD 598

Query: 515 VNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNR 574
            +E  +G+PF F + +  P I+ +W +   N T+A L+ ++      Y IPI VKD   +
Sbjct: 599 PDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQ 658

Query: 575 ACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIG 634
           A    +++++  C+C     C  +  +                      + V LG   I 
Sbjct: 659 AA--TKLLRVNLCECTHPTQCRATSRS----------------------TGVILGKWAIL 694

Query: 635 MMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVS 694
            ++LGI LL  + LL L+C                   G  G  +  R     PED    
Sbjct: 695 AILLGIALL-FSVLLTLVC-------------------GVFGATKGKRF----PEDLAQQ 730

Query: 695 NICAPMTASNTQDRMDSSEIY----TNTYAAG-------GTVEGGVSGVE-LNTGMGTAV 742
           N+    T +   DR+ S+  +    TN  + G       G   GG   +E +  G  T  
Sbjct: 731 NLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLE 790

Query: 743 GLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDC 802
               AG      + R   + +   R Y  ++ + +F      EK +     ++  P+ D 
Sbjct: 791 SCRGAGHHHTLDSCRGGHTEVDNCR-YTYSEWH-SFTQPRLGEKLHRCNQNEDRMPSQDY 848

Query: 803 LLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEIC 847
           +L Y++EG GSP GS+GCCS   ++     +  L+PKF TLAE C
Sbjct: 849 VLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEAC 893


>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
           sapiens]
          Length = 894

 Score =  342 bits (878), Expect = 8e-94
 Identities = 259/826 (31%), Positives = 389/826 (47%), Gaps = 73/826 (8%)

Query: 39  TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98
           TK   ++R KR W    A+  E         + +I+SD   N  I Y ISG G+D+ P+ 
Sbjct: 124 TKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFN 183

Query: 99  VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
           +F I   TG+I  T  +DRE    F +Y  A  + G   E PL L +K+ D NDNAP F 
Sbjct: 184 LFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFE 243

Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218
             V   ++ EN  + T V K+ ATD DE + L++++ YKI+ Q P     F ++  TG +
Sbjct: 244 HRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVI 303

Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
            T + FLDRE+   Y L++   D  G   GL +     I + D NDN P+  +TSY   +
Sbjct: 304 TTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEV 363

Query: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338
           EEN +  E++R++  D D   T +  A Y IL GN+   F I TDP TNEG+L VVK L+
Sbjct: 364 EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLN 423

Query: 339 YEQAPNIQLSIGVKNQADFHYSVASQF-QMHPTPVRIQVVDVREGPAFHPSTMAFSVREG 397
           YE    + L +GV N+A F  + +SQ   M  T V ++++D  EGP  HP       ++G
Sbjct: 424 YEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDG 483

Query: 398 I-KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKS 456
              G  LL      Y A+D +  +    +RY    D  +W +I+  TG+++  +  D++S
Sbjct: 484 FPAGQELLG-----YKALDPEISS-GEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRES 537

Query: 457 KYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSP--SVLIS 514
           K++ N  Y   ++A+ D  G++ TGT+ + + D ND+ P I  E  TIC ++   +VL  
Sbjct: 538 KFVKNNQYNISVVAV-DAVGRSCTGTLVVHLDDYNDHAPQIDKE-VTICQNNEDFAVLKP 595

Query: 515 VNEH--SYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSY 572
           V+      G PF F + +     +  W++   +  +AIL  +Q L   +Y +PI +KD +
Sbjct: 596 VDPDGPENGPPFQFFLDN---SASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRH 652

Query: 573 NRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAG 632
                   M+ +  CDC     C     +   T D+                NV LG   
Sbjct: 653 GLVA--THMLTVRVCDCSTPSECRMKDKS---TRDVR--------------PNVILGRWA 693

Query: 633 IGMMVLGILLLILAPLLLLLCCC-------KQRQPEGLGTRFAPVPEGGEGVMQSWRIEG 685
           I  MVLG +LL+    +L  C C       K+  PE +  +   V             EG
Sbjct: 694 ILAMVLGSVLLL---CILFTCFCVTAKRTVKKCFPEDIAQQNLIVS----------NTEG 740

Query: 686 AHPEDRDVSNICAPMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVG-- 743
              E  + +NI  PM  SN  D          T  + GTV G   G++         G  
Sbjct: 741 PGEEVTE-ANIRLPMQTSNICD----------TSMSVGTVGG--QGIKTQQSFEMVKGGY 787

Query: 744 -LMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDC 802
            L +    G       +    G    YA  D   +F      EK Y    ++E +   D 
Sbjct: 788 TLDSNKGGGHQTLESVKGVGQGDTGRYAYTDW-QSFTQPRLGEKVYLCGQDEEHKHCEDY 846

Query: 803 LLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICL 848
           +  Y++EG GS  GS+GCCS   ++     ++ L+PKFRTLA+ C+
Sbjct: 847 VCSYNYEGKGSLAGSVGCCSDRQEEEGLEFLDHLEPKFRTLAKTCI 892


>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
           sapiens]
          Length = 847

 Score =  323 bits (827), Expect = 7e-88
 Identities = 226/718 (31%), Positives = 339/718 (47%), Gaps = 60/718 (8%)

Query: 39  TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98
           TK + +RR KR W     +  E         + +++SD   N  I Y I G G+D+ P  
Sbjct: 125 TKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRN 184

Query: 99  VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
           +F +   TG +  T  VDRE    F I   A    G   E PL L +K+ D NDN P+F+
Sbjct: 185 LFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFT 244

Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218
           +  YT +I EN    T V ++CATD DE + +++++ Y I+ Q P    +F ++  TG +
Sbjct: 245 EETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVI 304

Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
            T SS LDRE    Y L ++  D DG   GL +   C I + DVND+ PT  +TSY  S+
Sbjct: 305 TTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSV 364

Query: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338
           EEN +  E++R+   D D   T NW A Y IL GN+   F I TD +TNEG+L VVK L+
Sbjct: 365 EENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLN 424

Query: 339 YEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
           YE+   + L IGV N+A F    + +  M    V + V D  EGP  +P      ++E  
Sbjct: 425 YEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENA 484

Query: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKY 458
           +  +  N     Y A D +T   ++ +RY    D   W+ ID  TG I+  R  D++++ 
Sbjct: 485 EVGTTSN----GYKAYDPET-RSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAET 539

Query: 459 IINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSPS------VL 512
           I NGIY   +LA D G G+T TGT+ I + D+ND  P  F  ++T+ I  P+      V 
Sbjct: 540 IKNGIYNITVLASDQG-GRTCTGTLGIILQDVNDNSP--FIPKKTVIICKPTMSSAEIVA 596

Query: 513 ISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSY 572
           +  +E  +G PF F +      +  MW +++ N T+A L+ +     G Y +PI V+D  
Sbjct: 597 VDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRL 656

Query: 573 NRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAG 632
             +   +  V L  CDC   + C                      + + G   V LG   
Sbjct: 657 GMSSVTSLDVTL--CDCITENDCTHR------------------VDPRIGGGGVQLGKWA 696

Query: 633 IGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRD 692
           I  ++LGI LL    +L  L C                  G  G  +  ++    P+D  
Sbjct: 697 ILAILLGIALLFC--ILFTLVC------------------GASGTSKQPKV---IPDDLA 733

Query: 693 VSNICAPMTASNTQDRMDSSEIYTNTYAAGGTVEG--GVSGVELNTGMGTAVGLMAAG 748
             N+    T +   D++ S+  +T T   G + +G  G  G  +  G    + ++  G
Sbjct: 734 QQNLIVSNTEAPGDDKVYSANGFT-TQTVGASAQGVCGTVGSGIKNGGQETIEMVKGG 790


>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
          Length = 916

 Score =  323 bits (827), Expect = 7e-88
 Identities = 239/815 (29%), Positives = 377/815 (46%), Gaps = 81/815 (9%)

Query: 44  VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTIN 103
           +RR+KR+W+       E         + +IRSD +++  I Y I+GVG D+PP  VF+I+
Sbjct: 164 LRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSID 223

Query: 104 PRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
             +G + +T  +DRE    + +   A++  G  +E P++L + V+D+NDN P F   VY 
Sbjct: 224 SMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYN 283

Query: 164 ASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAP--MFILNRYTGEVCTM 221
            S++E S   T V+ + A DAD+    N  + Y+IV+Q P      MF +N  TG++ T+
Sbjct: 284 GSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTV 343

Query: 222 SSFLDREQHSMYNLVVRGSDRDGAAD-GLSSECDCRIKVLDVNDNFPTLEKTSYSASIEE 280
           ++ LDRE+   Y ++V+ +D +G  + GLS+     I V DVNDN P    ++++  + E
Sbjct: 344 AAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPE 403

Query: 281 NCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYE 340
           N + + +  L  +D D+  + NW A Y I+SG+    F ++TDP TNEG++ VVK +DYE
Sbjct: 404 NRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYE 463

Query: 341 QAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
                 L++ V NQA     +   FQ     V I ++D+ E P F  +     + EG+  
Sbjct: 464 LNRAFMLTVMVSNQAPLASGIQMSFQ-STAGVTISIMDINEAPYFPSNHKLIRLEEGVPP 522

Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYII 460
            +    VL T++A+D D       VRY    D  SWL I++  G+I  +   D++S Y  
Sbjct: 523 GT----VLTTFSAVDPDRFMQQA-VRYSKLSDPASWLHINATNGQITTAAVLDRESLYTK 577

Query: 461 NGIYTAEILAIDDG-SGKTATGTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHS 519
           N +Y A  LA D+G    + TGT+ I + DIND  P + P+   IC       I++    
Sbjct: 578 NNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAAD 637

Query: 520 YG-----SPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQV-LSPGFYEIPILVKDSYN 573
                   P+ F +   P  +   W +   N   A L+ + + L  G Y++PI+V DS N
Sbjct: 638 ADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGN 697

Query: 574 RACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGI 633
                  ++++  C CDDN  C   GA                      V+  GLG   I
Sbjct: 698 PPLSNTSIIKVKVCPCDDNGDCTTIGA----------------------VAAAGLGTGAI 735

Query: 634 GMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGG-EGVMQSWRIEGAHPEDRD 692
            + +L  +L++L  +LL +   K+R+ E    +    PE      +  +  EG   ED+D
Sbjct: 736 -VAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQD 794

Query: 693 VSNICAPMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGA 752
                            D S++      A G V     GV         V     GA   
Sbjct: 795 ----------------YDLSQL--QQPEAMGHVPSKAPGVR-------RVDERPVGAE-P 828

Query: 753 SGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVG 812
               R      G + D+ +  +  A              D D   P  D LL++D+EG G
Sbjct: 829 QYPIRPMVPHPGDIGDFINEGLRAA--------------DNDPTAPPYDSLLVFDYEGSG 874

Query: 813 SPVGSIGCC-SWIVDDLDESCMETLDPKFRTLAEI 846
           S  GS+    S    D D   +    P+F+ LA++
Sbjct: 875 STAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADM 909


>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
          Length = 906

 Score =  317 bits (811), Expect = 5e-86
 Identities = 242/844 (28%), Positives = 376/844 (44%), Gaps = 103/844 (12%)

Query: 24  EFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKI 83
           E IV  ++F   +G      ++RQKR+W+       E         + +IRSD + N  +
Sbjct: 139 EEIVFPRQFSKHSGH-----LQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSL 193

Query: 84  TYRISGVGIDRPPYGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLEL 143
            Y ++G G D+PP G+F INP +G++++T  +DRE    F +   A++  G  +E P+++
Sbjct: 194 RYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDI 253

Query: 144 RVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEP 203
            + V+D+NDN P F   V+  ++ E S   T V+ + A DAD+ N LN  + Y+IVSQ P
Sbjct: 254 VINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAP 313

Query: 204 S--GAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDG-AADGLSSECDCRIKVL 260
           S     MF +N  TG++ T+++ LDRE+   Y L+++ +D +G    GLS+     I V 
Sbjct: 314 STPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVT 373

Query: 261 DVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDI 320
           DVNDN P     ++   + EN +   +  L   D D+  T  W A Y I  G+    F I
Sbjct: 374 DVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAI 433

Query: 321 QTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVR 380
           QTDP +N+G++ VVK +D+E      L++  +NQ      +    Q   T V + V+DV 
Sbjct: 434 QTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTAT-VSVTVIDVN 492

Query: 381 EGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKID 440
           E P F P+       EG+   ++L     T+TA D D      ++RY    D  +WLKID
Sbjct: 493 ENPYFAPNPKIIRQEEGLHAGTMLT----TFTAQDPDR-YMQQNIRYTKLSDPANWLKID 547

Query: 441 SRTGEIQFSREFDKKSKYIINGIYTAEILAIDDG-SGKTATGTICIEVPDINDYCPNIFP 499
              G+I      D++S  + N IY A  LA D+G    + TGT+ I + DIND  P + P
Sbjct: 548 PVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLP 607

Query: 500 ERRTICIDSPSVLISVNEHSY-----GSPFTFCVVDEPPGIADMWDVRSTNATSAILTAK 554
           +    C       I++    Y       PF F +   P  I   W +   N   A L  K
Sbjct: 608 QEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLK 667

Query: 555 -QVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTY 613
            + L  G YE+PI++ DS N       ++++  C CD N  C D        + I G   
Sbjct: 668 IKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTD-------VDRIVG--- 717

Query: 614 GPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEG 673
                        GLG   I  ++L I++L++  +L+ +   K+R  E    +    PE 
Sbjct: 718 ------------AGLGTGAIIAILLCIIILLIL-VLMFVVWMKRRDKERQAKQLLIDPED 764

Query: 674 G-EGVMQSWRIEGAHPEDR--DVSNICAPMTASNTQ------DRMDSSEIYTNTYAAGGT 724
                +  +  EG   ED+  D+S +  P T            RMD   I+         
Sbjct: 765 DVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRMDERPIH--------- 815

Query: 725 VEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFS 784
                                    A      R  +   G + D+ +  +          
Sbjct: 816 -------------------------AEPQYPVRSAAPHPGDIGDFINEGLKA-------- 842

Query: 785 EKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGC--CSWIVDDLDESCMETLDPKFRT 842
                 AD D   P  D LL++D+EG GS  GS+     S    + D   +    P+F+ 
Sbjct: 843 ------ADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKK 896

Query: 843 LAEI 846
           LA++
Sbjct: 897 LADM 900


>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
           sapiens]
          Length = 839

 Score =  310 bits (794), Expect = 5e-84
 Identities = 196/619 (31%), Positives = 308/619 (49%), Gaps = 35/619 (5%)

Query: 39  TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98
           T+   +RR KR W     + +E         + ++ SD   N  + Y ISG G+D+ P  
Sbjct: 125 TRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLN 184

Query: 99  VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
           +F I   TG +  T  VDRE   +F +   A  + G   + PL L ++V D NDN PVF+
Sbjct: 185 LFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFT 244

Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218
           +++Y   + E+S   T V  +CATD DE + +++++ Y I+ Q P    +F ++  TG +
Sbjct: 245 EAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVI 304

Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
            T+S +LDRE    Y+L+++  D DG   GL     C I V D NDN PT  + +Y A +
Sbjct: 305 TTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFV 364

Query: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338
           EEN  + E++R+   D D   T NW   + IL GN+   F I TD +TNEG+L VVK L+
Sbjct: 365 EENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLN 424

Query: 339 YEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
           YE+   + L IGV N+A F   +     ++   V + V D+ EGP   P+     ++E +
Sbjct: 425 YEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENL 484

Query: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKY 458
              S +N     Y A D +  N    +RY   HD   W+ ID  +G I  S+  D++ + 
Sbjct: 485 AVGSKIN----GYKAYDPENRN-GNGLRYKKLHDPKGWITIDEISGSIITSKILDREVET 539

Query: 459 IINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICID----SPSVLIS 514
             N +Y   +LAID    ++ TGT+ + + D+ND  P I  E   IC      +  + + 
Sbjct: 540 PKNELYNITVLAIDK-DDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVD 598

Query: 515 VNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNR 574
            +E  +G+PF F + +  P I+ +W +   N T+A L+ ++      Y IPI VKD   +
Sbjct: 599 PDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQ 658

Query: 575 ACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIG 634
           A    +++++  C+C     C  +  +                      + V LG   I 
Sbjct: 659 AA--TKLLRVNLCECTHPTQCRATSRS----------------------TGVILGKWAIL 694

Query: 635 MMVLGILLLILAPLLLLLC 653
            ++LGI LL  + LL L+C
Sbjct: 695 AILLGIALL-FSVLLTLVC 712


>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
          Length = 840

 Score =  303 bits (775), Expect = 7e-82
 Identities = 206/623 (33%), Positives = 311/623 (49%), Gaps = 39/623 (6%)

Query: 39  TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98
           TK   ++R KR W    A+  E         + +I+SD   N  I Y ISG G+D+ P+ 
Sbjct: 124 TKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFN 183

Query: 99  VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
           +F I   TG+I  T  +DRE    F +Y  A  + G   E PL L +K+ D NDNAP F 
Sbjct: 184 LFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFE 243

Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218
             V   ++ EN  + T V K+ ATD DE + L++++ YKI+ Q P     F ++  TG +
Sbjct: 244 HRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVI 303

Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
            T + FLDRE+   Y L++   D  G   GL +     I + D NDN P+  +TSY   +
Sbjct: 304 TTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEV 363

Query: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338
           EEN +  E++R++  D D   T +  A Y IL GN+   F I TDP TNEG+L VVK L+
Sbjct: 364 EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLN 423

Query: 339 YEQAPNIQLSIGVKNQADFHYSVASQF-QMHPTPVRIQVVDVREGPAFHPSTMAFSVREG 397
           YE    + L +GV N+A F  + +SQ   M  T V ++++D  EGP  HP       ++G
Sbjct: 424 YEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDG 483

Query: 398 I-KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKS 456
              G  LL      Y A+D +  +    +RY    D  +W +I+  TG+++  +  D++S
Sbjct: 484 FPAGQELLG-----YKALDPEISS-GEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRES 537

Query: 457 KYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSP--SVLIS 514
           K++ N  Y   ++A+ D  G++ TGT+ + + D ND+ P I  E  TIC ++   +VL  
Sbjct: 538 KFVKNNQYNISVVAV-DAVGRSCTGTLVVHLDDYNDHAPQIDKE-VTICQNNEDFAVLKP 595

Query: 515 VNEH--SYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSY 572
           V+      G PF F + +     +  W++   +  +AIL  +Q L   +Y +PI +KD +
Sbjct: 596 VDPDGPENGPPFQFFLDN---SASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRH 652

Query: 573 NRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAG 632
                   M+ +  CDC     C     +   T D+                NV LG   
Sbjct: 653 GLVA--THMLTVRVCDCSTPSECRMKDKS---TRDVR--------------PNVILGRWA 693

Query: 633 IGMMVLGILLLILAPLLLLLCCC 655
           I  MVLG +LL+    +L  C C
Sbjct: 694 ILAMVLGSVLLL---CILFTCFC 713


>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
          Length = 814

 Score =  301 bits (771), Expect = 2e-81
 Identities = 231/815 (28%), Positives = 381/815 (46%), Gaps = 91/815 (11%)

Query: 46  RQKREWIKFAAACREGEDNSKR--NPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTIN 103
           R +R W+    +  E   N KR   P+ +I+SD +    + Y I G G+D  P GVF+I+
Sbjct: 42  RVRRAWVIPPISVSE---NHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSID 98

Query: 104 PRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
             TG++ + +++DRE T  F +   AL+  G  LE P +L + V+D NDN P F Q  +T
Sbjct: 99  KFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFT 158

Query: 164 ASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAP-MFILNRYTGEVCTMS 222
             + E +   T V +  ATDAD+    N+ + + I+ Q   G+P +F ++  TGE+ T+ 
Sbjct: 159 GRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ---GSPELFSIDELTGEIRTVQ 215

Query: 223 SFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENC 282
             LDRE  ++YNL ++ +D  G  DGL++     I + D+NDN P   +  +     E  
Sbjct: 216 VGLDREVVAVYNLTLQVADMSG--DGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAV 273

Query: 283 LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQA 342
              ++ RL+  D D  G+ NW+A++ IL G+    F I+TDP+TNEG+L +VK LDYE  
Sbjct: 274 SGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESC 333

Query: 343 PNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSS 402
            + +L + V+N+A    + A + +     VR+ V D  E P F  + +  S+ EG    +
Sbjct: 334 EHYELKVSVQNEAPLQ-AAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGT 392

Query: 403 LLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIING 462
           L    + T++A D DT      + Y   +D   WL++D+ TG IQ        S ++  G
Sbjct: 393 L----VATFSARDPDT-EQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGG 447

Query: 463 IYTAEILAIDDGS-GKTATGTICIEVPDINDYCPNIF-PERRTICID---SPSVLISVNE 517
            Y A +LA DD S  +TATGT+ IE+ ++ND+ P +  P   ++C +    P +L+   +
Sbjct: 448 WYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATD 507

Query: 518 HS---YGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNR 574
                +G+PF F +    P +   W +   N + A L  +  +  G + + +L++DS   
Sbjct: 508 EDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQP 567

Query: 575 ACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIG 634
             +  Q + +  C C  + +CL   AA +                 AG + + LG   + 
Sbjct: 568 PQQREQPLNVTVCRCGKDGVCLPGAAALL-----------------AGGTGLSLG--ALV 608

Query: 635 MMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVS 694
           +++   LLL++  LL+ L     +Q  G G    P  +  + V+ ++  +G   ED+D  
Sbjct: 609 IVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVL-NYDEQGGGEEDQDAY 667

Query: 695 NICAPMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASG 754
           +I                                 S +   T +   +G           
Sbjct: 668 DI---------------------------------SQLRHPTALSLPLG----------P 684

Query: 755 AARKRSSTMGTLRDYADADINMAFLD-SYFSEKAYAYADEDEGRPANDCLLIYDHEGVGS 813
              +R +  G L       +  + LD + F       AD D   P  D  LIYD+EG GS
Sbjct: 685 PPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGS 744

Query: 814 PVGSIG--CCSWIVDDLDESCMETLDPKFRTLAEI 846
             G++     S   +D D   +    P+F  LA++
Sbjct: 745 VAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADM 779


>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
          Length = 882

 Score =  295 bits (756), Expect = 1e-79
 Identities = 244/820 (29%), Positives = 378/820 (46%), Gaps = 110/820 (13%)

Query: 44  VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTIN 103
           +RRQKR+W+    +C E E       + +I+S+ +   K+ Y I+G G D PP GVF I 
Sbjct: 149 LRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIE 208

Query: 104 PRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
             TG + +T  +DRE    + ++  A++S G  +E P+E+ + V D NDN P F+Q V+ 
Sbjct: 209 RETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFK 268

Query: 164 ASIEENSDANTLVVKLCATDADEE-NHLNSKIAYKIVSQEPS--GAPMFILNRYTGEVCT 220
            S+ E +   T V+++ ATDAD++ N  N+ IAY I+SQ+P      MF +NR TG +  
Sbjct: 269 GSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISV 328

Query: 221 MSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEE 280
           +++ LDRE    Y LVV+ +D  G  +GLS+     I V D NDN P    T+Y   + E
Sbjct: 329 VTTGLDRESFPTYTLVVQAADLQG--EGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPE 386

Query: 281 NCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYE 340
           N  +  +  L+  D D   T  W A Y IL+ +DG  F + T+P  N+GILK  K LD+E
Sbjct: 387 NEANVVITTLKVTDADAPNTPAWEAVYTILN-DDGGQFVVTTNPVNNDGILKTAKGLDFE 445

Query: 341 QAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
                 L + V N   F  S+ +        V + V+DV E P F P      V E    
Sbjct: 446 AKQQYILHVAVTNVVPFEVSLTTS----TATVTVDVLDVNEAPIFVPPEKRVEVSEDFG- 500

Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKS-KYI 459
              +   + +YTA + DT      + Y I  D  +WL+I+  TG I    E D++  +++
Sbjct: 501 ---VGQEITSYTAQEPDT-FMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHV 556

Query: 460 INGIYTAEILAIDDGSG-KTATGTICIEVPDINDYCPNIFPERRTI--CIDSPSV----L 512
            N  YTA I+A D+GS   T TGT+ + + D+ND  P   PE RTI  C  +P      +
Sbjct: 557 KNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAP--IPEPRTIFFCERNPKPQVINI 614

Query: 513 ISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNAT--SAILTAKQVLSPGFYEIPILVKD 570
           I  +     SPFT    +   G +  W ++  + T  S IL  K  L  G Y+I + + D
Sbjct: 615 IDADLPPNTSPFT---AELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMD 671

Query: 571 SYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGP 630
           + N+  +    +++  CDC+        GAAG+  +        PV   +AG+      P
Sbjct: 672 NQNK--DQVTTLEVSVCDCE--------GAAGVCRK------AQPV---EAGLQI----P 708

Query: 631 AGIGMM--VLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHP 688
           A +G++  +L +L+LIL  LL L      ++P        P  +     +  +  EG   
Sbjct: 709 AILGILGGILALLILILLLLLFLRRRAVVKEP------LLPPEDDTRDNVYYYDEEGGGE 762

Query: 689 EDRDVSNICAPMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAG 748
           ED+D                 D S+++    A        V                   
Sbjct: 763 EDQD----------------FDLSQLHRGLDARPEVTRNDV------------------- 787

Query: 749 AAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDH 808
                      + T+ ++  Y     N   + ++  E   A AD D   P  D LL++D+
Sbjct: 788 -----------APTLMSVPRYLPRPANPDEIGNFIDENLKA-ADTDPTAPPYDSLLVFDY 835

Query: 809 EGVGSPVGSIGCCSWIVDDLDE--SCMETLDPKFRTLAEI 846
           EG GS   S+   +    D D+    +     +F+ LA++
Sbjct: 836 EGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADM 875


>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
          Length = 713

 Score =  278 bits (712), Expect = 1e-74
 Identities = 183/577 (31%), Positives = 291/577 (50%), Gaps = 34/577 (5%)

Query: 44  VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTIN 103
           V RQKR  +       E +       + K+  D +  ++  +R++G G+D+ P G+F IN
Sbjct: 133 VPRQKRSIVVSPILIPENQRQPFPRDVGKV-VDSDRPERSKFRLTGKGVDQEPKGIFRIN 191

Query: 104 PRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
             TG +++T  +DRE+  ++ ++    +  G+ LE P+ L V V+D NDN P+F +  Y 
Sbjct: 192 ENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYI 251

Query: 164 ASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPS--GAPMFILNRYTGEVCTM 221
             + E S   T V+++ A DAD+    N+ + Y I  Q P      MF ++   G++ T+
Sbjct: 252 GHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTV 311

Query: 222 SS--FLDRE--QHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSAS 277
            S   LDRE  ++  Y L++   D  G   GL+      I + D ND+ P   K  + A+
Sbjct: 312 VSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQAT 371

Query: 278 IEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKML 337
           +EE  +   ++ L   D D+  T  W A Y I++GN G  F+I T+PQTNEG+L VVK L
Sbjct: 372 VEEGAV-GVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPL 430

Query: 338 DYEQAPNIQLSIGVKNQ----ADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFS 393
           DYE +    L I V+N+     D  Y  +S   +H     I V+DV EGP F+P  M  +
Sbjct: 431 DYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVH-----ITVLDVNEGPVFYPDPMMVT 485

Query: 394 VREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFD 453
            +E +   S    VL T  A D D+    T +RY +  D   WL I+   G +  +   D
Sbjct: 486 RQEDLSVGS----VLLTVNATDPDSLQHQT-IRYSVYKDPAGWLNINPINGTVDTTAVLD 540

Query: 454 KKSKYIINGIYTAEILAIDDGS-GKTATGTICIEVPDINDYCPNIFPERRTICIDSPSVL 512
           ++S ++ N +YTA  LAID G+   T TGT+ I + D+ND  P I+P    +C D+ ++ 
Sbjct: 541 RESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLS 600

Query: 513 ISV------NEHSYGSPFTFCVVDEPPGIAD-MWDVRSTNATSAILTAKQVLSPGFYEIP 565
           + +      + H    PF F +      + D +W +   N T A+++  Q L+   Y +P
Sbjct: 601 VVILGASDKDLHPNTDPFKFEI--HKQAVPDKVWKISKINNTHALVSLLQNLNKANYNLP 658

Query: 566 ILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAG 602
           I+V DS          +++  C C ++   +D  AAG
Sbjct: 659 IMVTDSGKPPMTNITDLRVQVCSCRNSK--VDCNAAG 693


>gi|29570800 cadherin-like 26 isoform a [Homo sapiens]
          Length = 832

 Score =  272 bits (695), Expect = 1e-72
 Identities = 184/617 (29%), Positives = 301/617 (48%), Gaps = 39/617 (6%)

Query: 9   ICLLIILMVVMEVNSEFIVEVKEFDIENGTTK--WQTVRRQKREWIKFAAACREGEDNSK 66
           + LL++L+ +++V+    V+ +  D+   T +  +Q +RR KR W+       E +    
Sbjct: 12  LLLLVLLLWLLQVSIIDSVQQETDDLTKQTKEKIYQPLRRSKRRWVITTLELEEEDPGPF 71

Query: 67  RNPIAKIRSDCESNQKITYRISGVGIDR-PPYGVFTINPR-TGEINITSVVDREITPLFL 124
              I ++ ++   N  + Y ISG G+D  P  G+F++     G I +   VDRE+TP F 
Sbjct: 72  PKLIGELFNNMSYNMSLMYLISGPGVDEYPEIGLFSLEDHENGRIYVHRPVDREMTPSFT 131

Query: 125 IYCRALN-SRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLCATD 183
           +Y   +  S G+ ++  L   +++ D+ND+AP F +  +  +++EN  A   + ++ A D
Sbjct: 132 VYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKEFNITVQENQSAGQPIFQMLAVD 191

Query: 184 ADEENHLNSKIAYKIVSQEP----SGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRG 239
            DEEN  NS++ Y ++SQ P    SG   F ++R +GE+  +S  LD E    + L++R 
Sbjct: 192 LDEENTPNSQVLYFLISQTPLLKESG---FRVDRLSGEI-RLSGCLDYETAPQFTLLIRA 247

Query: 240 SDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEG 299
             RD     LSS     + V + N++ P   + +Y   I E   S  ++RL   D D   
Sbjct: 248 --RDCGEPSLSSTTTVHVDVQEGNNHRPAFTQENYKVQIPEGRASQGVLRLLVQDRDSPF 305

Query: 300 TDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHY 359
           T  W A++ IL GN+   FDI TDP+TNEGIL V+K LDYE  P   L I V+N+    +
Sbjct: 306 TSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDYETRPAQSLIIVVENEERLVF 365

Query: 360 SVASQFQ-----MHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAI 414
               + Q          V +QV D  + PAFHP +   +  EG +  +L    LGT+ A+
Sbjct: 366 CERGKLQPPRKAAASATVSVQVTDANDPPAFHPQSFIVNKEEGARPGTL----LGTFNAM 421

Query: 415 DLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDG 474
           D     P + +RY + HD  +W+ +D  +G +      D++S ++ N  Y   I A+DDG
Sbjct: 422 D-----PDSQIRYELVHDPANWVSVDKNSGVVITVEPIDRESPHVNNSFYVIIIHAVDDG 476

Query: 475 -SGKTATGTICIEVPDINDYCPNIFPERR--TICIDSPSVLISVNEHS-----YGSPFTF 526
              +TATGT+ + + DIND  P + P  R   +C  +    + +         +  PFTF
Sbjct: 477 FPPQTATGTLMLFLSDINDNVPTLRPRSRYMEVCESAVHEPLHIEAEDPDLEPFSDPFTF 536

Query: 527 CVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYA 586
            + +      D W +      S  L   + L  G Y +P+ + D   +     Q V +  
Sbjct: 537 ELDNTWGNAEDTWKLGRNWGQSVELLTLRSLPRGNYLVPLFIGD--KQGLSQKQTVHVRI 594

Query: 587 CDCDDNHMCLDSGAAGI 603
           C C     C++   A +
Sbjct: 595 CPCASGLTCVELADAEV 611


>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
          Length = 829

 Score =  266 bits (679), Expect = 1e-70
 Identities = 173/557 (31%), Positives = 284/557 (50%), Gaps = 29/557 (5%)

Query: 44  VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTIN 103
           +RR KR+W+    +  E         + +++S+ + + KI Y I+G G D PP GVF + 
Sbjct: 102 LRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVE 161

Query: 104 PRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
             TG + +   +DRE    + ++  A++  G  +E P+ + + V D ND+ P F+Q  + 
Sbjct: 162 KETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFR 221

Query: 164 ASIEENSDANTLVVKLCATDADEENHL-NSKIAYKIVSQEPSGAP--MFILNRYTGEVCT 220
            S+ E     T V+++ ATD D+  +  N  +AY I SQEP      MF ++R TG +  
Sbjct: 222 GSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISV 281

Query: 221 MSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEE 280
           +SS LDRE+   Y L ++ +D DG  DG ++     +++LD NDN P  +   Y A + E
Sbjct: 282 ISSGLDREKVPEYTLTIQATDMDG--DGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPE 339

Query: 281 NCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYE 340
           N +  E+ RL   DLD   +  W A YLI+ G+DG+ F I T P++N+GIL   K LD+E
Sbjct: 340 NAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFE 399

Query: 341 QAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
                 L + V N+A F   + +        + + V DV E P F P +    V+EGI  
Sbjct: 400 AKNQHTLYVEVTNEAPFVLKLPTS----TATIVVHVEDVNEAPVFVPPSKVVEVQEGIPT 455

Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKK-SKYI 459
                  +  YTA D D  N    + Y I  D   WL +D  +G++      D++  +++
Sbjct: 456 GE----PVCVYTAEDPDKEN--QKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFV 509

Query: 460 INGIYTAEILAIDDGS-GKTATGTICIEVPDINDYCPNIFPERRTICIDSP-SVLISVNE 517
            N IY   +LA+D+GS   T TGT+ + + D+ND+ P   P + TIC  SP   ++++ +
Sbjct: 510 RNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITD 569

Query: 518 HS---YGSPFTFCVVDEPPGIADMWDVRSTN--ATSAILTAKQVLSPGFYEIPILVKDSY 572
                + SPF   + D+    +D++     N    + +L+ K+ L    Y++ + + D  
Sbjct: 570 KDLSPHTSPFQAQLTDD----SDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHG 625

Query: 573 NRACELAQMVQLYACDC 589
           N+  E   +++   CDC
Sbjct: 626 NK--EQLTVIRATVCDC 640



 Score = 31.2 bits (69), Expect = 5.3
 Identities = 17/58 (29%), Positives = 29/58 (50%), Gaps = 2/58 (3%)

Query: 791 ADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDE--SCMETLDPKFRTLAEI 846
           A+ D   P  D LL++D+EG GS   S+   +    D D+    +     +F+ LA++
Sbjct: 765 ANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADM 822


>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
          Length = 790

 Score =  195 bits (495), Expect = 2e-49
 Identities = 188/690 (27%), Positives = 303/690 (43%), Gaps = 69/690 (10%)

Query: 44  VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTI 102
           + R KR W+       E    S    + K+ SD +     + Y +SG G       +F I
Sbjct: 48  LNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAG----DLFII 103

Query: 103 NPRTGEINITSVVDREITPLFLIYCRALNSR-GEDLERPLELRVKVMDINDNAPVFSQSV 161
           N  TG+I  T  +DRE  P++++  +A+N R G  +E   E  +K+ DINDN P+F++ V
Sbjct: 104 NENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEV 163

Query: 162 YTASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCT 220
           YTA++ E SD  T VV++ ATDAD+  + NS K+ Y I+     G P F +   TG + T
Sbjct: 164 YTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSIL----QGQPYFSVESETGIIKT 219

Query: 221 MSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEE 280
               +DRE    Y +V++  D  G   GLS      I + DVNDN P   +++Y     E
Sbjct: 220 ALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPE 279

Query: 281 NCLSSELI-RLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDY 339
           +      I R++A D D    +N   +Y I  G   + FD+ TD +T EGI+ V K+LD+
Sbjct: 280 SSPPGTPIGRIKASDADV--GENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDF 337

Query: 340 EQAPNIQLSIGVKN-QADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
           E+     L +   N   +  +     F+   T VRI V DV E P F        +RE  
Sbjct: 338 EKKKVYTLKVEASNPYVEPRFLYLGPFKDSAT-VRIVVEDVDEPPVFSKLAYILQIRE-- 394

Query: 399 KGSSLLNYVLGTYTAIDLDTG-NPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDKK 455
              + +N  +G+ TA D D   NP   V+Y +    D      IDS  G I  S+  D++
Sbjct: 395 --DAQINTTIGSVTAQDPDAARNP---VKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRE 449

Query: 456 SKYIINGIYTAEILAIDDGSGKTATGT-ICIEVPDINDYCPNIFPERRTICIDSPSV--- 511
           +    N      ++A +  + K ++   + I+V D+ND  P       T   +       
Sbjct: 450 TLLWHN----ITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQL 505

Query: 512 -----LISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLS---PGFYE 563
                 +  ++   G  F+F +  E    ++     + + T+ ILT K   +      Y 
Sbjct: 506 IQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYL 565

Query: 564 IPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGV 623
           +P+++ D+          V +  C C D+H  + S  A                  +A +
Sbjct: 566 LPVVISDNDYPVQSSTGTVTVRVCAC-DHHGNMQSCHA------------------EALI 606

Query: 624 SNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRI 683
              GL    +  ++L I++L L  ++L     +QR+ E L      + +     + S+  
Sbjct: 607 HPTGLSTGALVAILLCIVIL-LVTVVLFAALRRQRKKEPLIISKEDIRDN----IVSYND 661

Query: 684 EGAHPEDR---DVSNICAPMTASNTQDRMD 710
           EG   ED    D+  +  P    + + R D
Sbjct: 662 EGGGEEDTQAFDIGTLRNPEAIEDNKLRRD 691



 Score = 31.2 bits (69), Expect = 5.3
 Identities = 17/57 (29%), Positives = 26/57 (45%), Gaps = 2/57 (3%)

Query: 792 DEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDE--SCMETLDPKFRTLAEI 846
           D D   P  D L  Y +EG GS   S+     +  D D+    +    P+F+ LA++
Sbjct: 724 DTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADM 780


>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
          Length = 785

 Score =  194 bits (494), Expect = 3e-49
 Identities = 177/637 (27%), Positives = 284/637 (44%), Gaps = 61/637 (9%)

Query: 46  RQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTINP 104
           R KR W+       E    S    + K+ SD +     I Y +SG G       +F I+ 
Sbjct: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99

Query: 105 RTGEINITSVVDREITPLFLIYCRALNS-RGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
            TG+I+ T  +DRE    + +  +AL+    + +E   E  +K+ DINDN P F    YT
Sbjct: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159

Query: 164 ASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCTMS 222
           A + E S   T VV++ ATDAD+  + NS ++ Y I+     G P F +   TG + T  
Sbjct: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSIL----QGQPYFSVEPKTGVIKTAL 215

Query: 223 SFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENC 282
             +DRE    Y LV++  D  G   GLS      + + DVNDN P   + SY  ++ E+ 
Sbjct: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275

Query: 283 -LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQ 341
            ++S + R++A D D     N   +Y I+ G+    F I  D +T EGI+ + K LD+E 
Sbjct: 276 PVASVVARIKAADADIGA--NAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333

Query: 342 APNIQLSIGVKNQ-ADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
             +  L I   N+ AD  +     F    T V+I V DV E P F        V E    
Sbjct: 334 KTSYTLRIEAANKDADPRFLSLGPFS-DTTTVKIIVEDVDEPPVFSSPLYPMEVSE---- 388

Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDKKSKY 458
           ++ +  ++GT  A D D+ N  + VRY I    D   +  ID+ +G I  ++  D+++  
Sbjct: 389 ATQVGNIIGTVAAHDPDSSN--SPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET-- 444

Query: 459 IINGIYTAEILAID-DGSGKTATGTICIEVPDINDYCPNIFPE-RRTICIDS-PSVLI-- 513
             N I+   +LA++     +   G + I + DIND  P    +   T+C ++ P  +I  
Sbjct: 445 --NAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQK 502

Query: 514 ----SVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVL---SPGFYEIPI 566
                 +E S G  F F +  +     +     + + T++ILT +          Y +PI
Sbjct: 503 ISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPI 562

Query: 567 LVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNV 626
            + DS + +      + +  CDCD                    D        +A V   
Sbjct: 563 FIVDSGSPSLSSTNTLTIRVCDCD-------------------ADGVAQTCNAEAYVLPA 603

Query: 627 GLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGL 663
           GL    +  ++  +L L++  L+LL+   ++R+ E L
Sbjct: 604 GLSTGALIAILACVLTLLV--LILLIVTMRRRKKEPL 638


>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
          Length = 785

 Score =  194 bits (494), Expect = 3e-49
 Identities = 177/637 (27%), Positives = 284/637 (44%), Gaps = 61/637 (9%)

Query: 46  RQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTINP 104
           R KR W+       E    S    + K+ SD +     I Y +SG G       +F I+ 
Sbjct: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99

Query: 105 RTGEINITSVVDREITPLFLIYCRALNS-RGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
            TG+I+ T  +DRE    + +  +AL+    + +E   E  +K+ DINDN P F    YT
Sbjct: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159

Query: 164 ASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCTMS 222
           A + E S   T VV++ ATDAD+  + NS ++ Y I+     G P F +   TG + T  
Sbjct: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSIL----QGQPYFSVEPKTGVIKTAL 215

Query: 223 SFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENC 282
             +DRE    Y LV++  D  G   GLS      + + DVNDN P   + SY  ++ E+ 
Sbjct: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275

Query: 283 -LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQ 341
            ++S + R++A D D     N   +Y I+ G+    F I  D +T EGI+ + K LD+E 
Sbjct: 276 PVASVVARIKAADADIGA--NAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333

Query: 342 APNIQLSIGVKNQ-ADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
             +  L I   N+ AD  +     F    T V+I V DV E P F        V E    
Sbjct: 334 KTSYTLRIEAANKDADPRFLSLGPFS-DTTTVKIIVEDVDEPPVFSSPLYPMEVSE---- 388

Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDKKSKY 458
           ++ +  ++GT  A D D+ N  + VRY I    D   +  ID+ +G I  ++  D+++  
Sbjct: 389 ATQVGNIIGTVAAHDPDSSN--SPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET-- 444

Query: 459 IINGIYTAEILAID-DGSGKTATGTICIEVPDINDYCPNIFPE-RRTICIDS-PSVLI-- 513
             N I+   +LA++     +   G + I + DIND  P    +   T+C ++ P  +I  
Sbjct: 445 --NAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQK 502

Query: 514 ----SVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVL---SPGFYEIPI 566
                 +E S G  F F +  +     +     + + T++ILT +          Y +PI
Sbjct: 503 ISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPI 562

Query: 567 LVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNV 626
            + DS + +      + +  CDCD                    D        +A V   
Sbjct: 563 FIVDSGSPSLSSTNTLTIRVCDCD-------------------ADGVAQTCNAEAYVLPA 603

Query: 627 GLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGL 663
           GL    +  ++  +L L++  L+LL+   ++R+ E L
Sbjct: 604 GLSTGALIAILACVLTLLV--LILLIVTMRRRKKEPL 638


>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
          Length = 794

 Score =  194 bits (493), Expect = 4e-49
 Identities = 180/641 (28%), Positives = 289/641 (45%), Gaps = 62/641 (9%)

Query: 45  RRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTIN 103
           +R KR W+       E    S+   + K+ SD +  +  + Y +SG G       VFTI+
Sbjct: 50  QRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGT----VFTID 105

Query: 104 PRTGEINITSVVDREITPLFLIYCRALN-SRGEDLERPLELRVKVMDINDNAPVFSQSVY 162
             TG+I+    +DRE  P + +  +A++    + LE   E  +KV DINDN P F    Y
Sbjct: 106 ETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPY 165

Query: 163 TASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCTM 221
            A++ E S     V+++ ATDAD+  + NS ++ Y I+     G P F ++  TG + T 
Sbjct: 166 VATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSIL----QGQPYFSIDPKTGVIRTA 221

Query: 222 SSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEEN 281
              +DRE    Y ++++  D  G   GL+      I + DVNDN P   K+ +   + E+
Sbjct: 222 LPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPES 281

Query: 282 C-LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYE 340
             + S + R++A+D D     N   +Y I+ G+ GN FDI TD  T EG++K+ K LD+E
Sbjct: 282 SPIGSAIGRIRAVDPD--FGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFE 339

Query: 341 QAPNIQLSIGVKN-QADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIK 399
                   +   N   D  +  A  F+   T V+I V+DV E P F        V E   
Sbjct: 340 TKKAYTFKVEASNLHLDHRFHSAGPFKDTAT-VKISVLDVDEPPVFSKPLYTMEVYE--- 395

Query: 400 GSSLLNYVLGTYTAIDLDTGNPATDVRYIIG--HDAGSWLKIDSRTGEIQFSREFDKKSK 457
             + +  ++G  TA DLD G+ A  VRY I    D  S+  ID   G I  +   D++S 
Sbjct: 396 -DTPVGTIIGAVTAQDLDVGSSA--VRYFIDWKSDGDSYFTIDGNEGTIATNELLDRES- 451

Query: 458 YIINGIYTAEILAIDDGSG-KTATGTICIEVPDINDYCPNI-FPERRTICIDS-PSVLIS 514
                 Y   I+A    +   T+   I I V D+N++ P I  P    +C ++ P  +I 
Sbjct: 452 ---TAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQ 508

Query: 515 V------NEHSYGSPFTFCVVDEPPGIADMWDVRS-TNATSAILTAKQVLS---PGFYEI 564
           +      +    G  F+F +  E   I   + VR   N T+ I T +   S      Y +
Sbjct: 509 IVSAADRDLSPAGQQFSFRLSPE-AAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFL 567

Query: 565 PILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVS 624
           P++++DS          + +  C CD +   L      I+                    
Sbjct: 568 PVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLP------------------ 609

Query: 625 NVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGT 665
            VGL   G  + +L  ++++LA ++L +   +Q++ + L T
Sbjct: 610 -VGLS-TGALIAILLCIVILLAIVVLYVALRRQKKKDTLMT 648


>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
          Length = 790

 Score =  189 bits (481), Expect = 9e-48
 Identities = 207/828 (25%), Positives = 347/828 (41%), Gaps = 110/828 (13%)

Query: 46  RQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTINP 104
           R KR W+       E         + K+ S+ +     + Y ++G G       +F I+ 
Sbjct: 50  RPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGT----IFIIDD 105

Query: 105 RTGEINITSVVDREITPLFLIYCRALNSR-GEDLERPLELRVKVMDINDNAPVFSQSVYT 163
            TG+I+ T  +DRE    ++++ +A++ R  + LE   E  +KV DINDNAP F+   Y 
Sbjct: 106 TTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYI 165

Query: 164 ASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCTMS 222
            ++ E SD  T V+++ ATDAD+  + NS ++ Y I+     G P F ++  TG + T  
Sbjct: 166 VTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSIL----QGQPYFSVDPKTGVIRTAL 221

Query: 223 SFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENC 282
             +DRE    Y++V++  D  G   GLS      I + DVNDN P   +  Y   + E+ 
Sbjct: 222 HNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESA 281

Query: 283 -LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQ 341
            + S + +++A D D     N    Y I++G+    F I TD +T EGIL + K L+YE+
Sbjct: 282 QVGSAVGKIKANDADT--GSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEK 339

Query: 342 APNIQLSI-GVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
             +  L+I G     DF +S    F+   T ++I V DV E P F   +    V E  K 
Sbjct: 340 KKSYTLNIEGANTHLDFRFSHLGPFK-DATMLKIIVGDVDEPPLFSMPSYLMEVYENAK- 397

Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDA--GSWLKIDSRTGEIQFSREFDKKSKY 458
              +  V+GT  A D D+ N    VRY I ++     +  ID+ TG I+ ++  D++   
Sbjct: 398 ---IGTVVGTVLAQDPDSTNSL--VRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETP 452

Query: 459 IINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDS--PSVLISV- 515
             N   TA  +   D     +  T+ I V D+ND  P +  E   I  ++  P  +I   
Sbjct: 453 WYNITVTASEI---DNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTI 509

Query: 516 -----NEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLS---PGFYEIPIL 567
                ++ + G  F F + +  P   +     + + T++ILT ++  S      Y +PI+
Sbjct: 510 SATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIM 569

Query: 568 VKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVG 627
           + D    +   +  + +  C C+ +       A                   +A +S+ G
Sbjct: 570 ISDGGIPSLSSSSTLTIRVCACERDGRVRTCHA-------------------EAFLSSAG 610

Query: 628 LGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAH 687
           L    +  ++L +L+L+   +++L    ++ + E L      V E     + ++  EG  
Sbjct: 611 LSTGALIAILLCVLILL--AIVVLFITLRRSKKEPLIISEEDVREN----VVTYDDEGGG 664

Query: 688 PEDRDVSNICAPMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAA 747
            ED +  +I A    S  ++     +I                                 
Sbjct: 665 EEDTEAFDITALRNPSAAEELKYRRDI--------------------------------- 691

Query: 748 GAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYD 807
                      R     T R    + +    +  +  ++  A AD D   P  D L  Y 
Sbjct: 692 -----------RPEVKLTPRHQTSSTLESIDVQEFIKQR-LAEADLDPSVPPYDSLQTYA 739

Query: 808 HEGVGSPVGSIGC--CSWIVDDLDESCMETLDPKFRTLAEICLNTEIE 853
           +EG  S  GSI     +    D D   +    P+F+ LAE+    E E
Sbjct: 740 YEGQRSEAGSISSLDSATTQSDQDYHYLGDWGPEFKKLAELYGEIESE 787


>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
          Length = 801

 Score =  184 bits (466), Expect = 5e-46
 Identities = 159/573 (27%), Positives = 257/573 (44%), Gaps = 42/573 (7%)

Query: 40  KWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYG 98
           K Q+ +R KR W+       E    +    + K+ SD +     I Y +SG G       
Sbjct: 50  KPQSHQRTKRSWVWNQFFVLEEYTGTDPLYVGKLHSDMDRGDGSIKYILSGEGAGI---- 105

Query: 99  VFTINPRTGEINITSVVDREITPLFLIYCRALNSR-GEDLERPLELRVKVMDINDNAPVF 157
           VFTI+  TG+I+    +DRE    + +  +AL+ R G  +E   E  +K+ DINDN P F
Sbjct: 106 VFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKF 165

Query: 158 SQSVYTASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTG 216
               Y A++ E S   T V+++ ATDAD+  + NS ++ Y I+     G P F ++  TG
Sbjct: 166 LDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSIL----QGQPYFSVDSKTG 221

Query: 217 EVCTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSA 276
            + T    +DRE    Y ++++  D  G   GL+      I + DVNDN P   +  Y  
Sbjct: 222 VIRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQM 281

Query: 277 SIEENC-LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVK 335
           S+ E+  +SS + R+ A DLDE    N   +Y I+ G+  + FDI TDP    GI+ V K
Sbjct: 282 SVLESAPISSTVGRVFAKDLDE--GINAEMKYTIVDGDGADAFDISTDPNFQVGIITVKK 339

Query: 336 MLDYEQAPNIQLSI-GVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSV 394
            L +E   +  L + G     +  +     FQ   T V I V DV E P F P      V
Sbjct: 340 PLSFESKKSYTLKVEGANPHLEMRFLNLGPFQ-DTTTVHISVEDVDEPPVFEPGFYFVEV 398

Query: 395 REGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYII--GHDAGSWLKIDSRTGEIQFSREF 452
            E +   + +  +    +A D D  N    +RY I    D G +  +D  TG +  +R  
Sbjct: 399 PEDVAIGTTIQII----SAKDPDVTN--NSIRYSIDRSSDPGRFFYVDITTGALMTARPL 452

Query: 453 DKKSKYIINGIYTAEILAID-DGSGKTATGTICIEVPDINDYCPNIFPE--RRTICIDSP 509
           D++        +   +LA++ +   +  +  + I+V D+ND  P  FP      +C ++ 
Sbjct: 453 DREE----FSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPE-FPRFYEAFVCENAK 507

Query: 510 S-------VLISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAK---QVLSP 559
           +         +  ++   G  F + +  E     +     + + T+ ILT +   +    
Sbjct: 508 AGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDNTARILTRRSGFRQQEQ 567

Query: 560 GFYEIPILVKDSYNRACELAQMVQLYACDCDDN 592
             + +PIL+ DS          + +  C CDD+
Sbjct: 568 SVFHLPILIADSGQPVLSSTGTLTIQVCSCDDD 600


>gi|16753221 cadherin 22 precursor [Homo sapiens]
          Length = 828

 Score =  179 bits (454), Expect = 1e-44
 Identities = 211/824 (25%), Positives = 333/824 (40%), Gaps = 90/824 (10%)

Query: 46  RQKREWIKFAAACREGEDNSKRNPIAKIRSDC-ESNQKITYRISGVGIDRPPYGVFTINP 104
           R KR W+       E    ++   + KI SD  E +  I Y ISG G       +F I+ 
Sbjct: 59  RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGT----IFLIDE 114

Query: 105 RTGEINITSVVDREITPLFLIYCRALNSRGEDLERP-LELRVKVMDINDNAPVFSQSVYT 163
            TG+I+    +DRE    + +  +A +     L  P  E  +KV DIND+ P F    Y 
Sbjct: 115 LTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYI 174

Query: 164 ASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCTMS 222
            S+ E S   T V+++ A+DAD+  + +S ++ Y ++     G   F ++  TG + T  
Sbjct: 175 GSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLD----GEHHFTVDPKTGVIRTAV 230

Query: 223 SFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENC 282
             LDRE    Y +V++ +D  G   GLS      I V DVNDN P   +  Y  SI+E+ 
Sbjct: 231 PDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESA 290

Query: 283 -LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQ 341
            + + + R++A D D     +        S + G+ F + TD  T E I+ V K LD+E 
Sbjct: 291 PIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFES 350

Query: 342 APNIQLSIGVKNQ-ADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
            P   + +   N+  D  ++    F+     VR+ V DV E P F P +    V+E  + 
Sbjct: 351 QPVHTVILEALNKFVDPRFADLGTFR-DQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQV 409

Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDKKSKY 458
            SL    +G  TA D D  N    VRY I    D      ID+ TG I   +  D+++  
Sbjct: 410 GSL----VGVVTARDPDAAN--RPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETA- 462

Query: 459 IINGIYTAEILAID-DGSGKTATGTICIEVPDINDYCPNI-FPERRTICIDS-PSVLISV 515
              G +   +LA++ D   + +  ++ I + D+ND  P +  P    +C D+ P  LI  
Sbjct: 463 ---GWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQT 519

Query: 516 ------NEHSYGSPFTFCVVDEPP-----GIADMWDVRSTNATSAILTAKQVLSPGFYEI 564
                 +E   G  F F +V E P      + D+ D  +   T  +   +Q      + +
Sbjct: 520 ISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQ--EQDVFFL 577

Query: 565 PILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVS 624
           PILV DS          + +  C CD +                            A V 
Sbjct: 578 PILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTT-------------------AFVM 618

Query: 625 NVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIE 684
              L P    ++ L + +LIL  L+LL+   ++     L    +   E     +  +  E
Sbjct: 619 AASLSPG--ALIALLVCVLILVVLVLLILTLRRHHKSHLS---SDEDEDMRDNVIKYNDE 673

Query: 685 GAHPEDRDVSNICAPMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGL 744
           G   +D +  ++ A  +  +                  G ++GG  G     G G   G 
Sbjct: 674 GGGEQDTEAYDMSALRSLYDF-----------------GELKGGDGGGSAGGGAGGGSG- 715

Query: 745 MAAGAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLL 804
              G AG+   A   S      +     + + +    + S K  A AD D   P  D   
Sbjct: 716 ---GGAGSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKV-ALADGDLSVPPYDAFQ 771

Query: 805 IYDHEGVGSPVGSIGC--CSWIVDDLDESCMETLDPKFRTLAEI 846
            Y  EG  SP  S+          + D + + +  P+FR LA +
Sbjct: 772 TYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAAL 815


>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
          Length = 796

 Score =  176 bits (445), Expect = 1e-43
 Identities = 173/645 (26%), Positives = 281/645 (43%), Gaps = 69/645 (10%)

Query: 42  QTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVF 100
           Q ++R KR W+       E         + ++ SD +S    I Y +SG G       +F
Sbjct: 46  QVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGT----IF 101

Query: 101 TINPRTGEINITSVVDREITPLFLIYCRALN-SRGEDLERPLELRVKVMDINDNAPVFSQ 159
            I+ ++G I+ T  +DRE    + +  +A++      LE P E  VKV DINDN P F  
Sbjct: 102 VIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLH 161

Query: 160 SVYTASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEV 218
             Y A++ E S+  T V+++ A+DAD+  + NS K+ Y I+     G P F +   TG +
Sbjct: 162 ETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSIL----EGQPYFSVEAQTGII 217

Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
            T    +DRE    Y++V++  D  G   GLS      I + DVNDN P   ++ Y  S+
Sbjct: 218 RTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSV 277

Query: 279 EENCLSSELI-RLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKML 337
            E  +  E + R++A D D    +N L  Y I+ G+    F+I TD +T EG++K+ K +
Sbjct: 278 SEAAVPGEEVGRVKAKDPDI--GENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPV 335

Query: 338 DYEQAPNIQLSIGVKN-QADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVRE 396
           D+E      L +   N   D  +     F+   T V+I V D  E P F   +    V+E
Sbjct: 336 DFETKRAYSLKVEAANVHIDPKFISNGPFKDTVT-VKISVEDADEPPMFLAPSYIHEVQE 394

Query: 397 GIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDK 454
                +    V+G   A D D  N  + +RY I    D   +  I+   G I+ ++  D+
Sbjct: 395 NAAAGT----VVGRVHAKDPDAAN--SPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDR 448

Query: 455 KSKYIIN-GIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNI-FPERRTIC------- 505
           +    +N  ++ AEI        + A   + I V D+ND  P    P    IC       
Sbjct: 449 EETAWLNITVFAAEI----HNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKP 504

Query: 506 -IDSPSVLISVNEH---SYGSPFTFCVVDEPPGIA--DMWDVRSTNATSAILTAKQ---- 555
             + P V IS ++    + G  F F +   PP I     + VR     +A + A++    
Sbjct: 505 LSNQPIVTISADDKDDTANGPRFIFSL---PPEIIHNPNFTVRDNRDNTAGVYARRGGFS 561

Query: 556 VLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGP 615
                 Y +PI++ D           + +  C CD N   L   A               
Sbjct: 562 RQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNA--------------- 606

Query: 616 VTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP 660
               +A + N GL    +  ++  I++L++  +L +    ++++P
Sbjct: 607 ----EAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEP 647



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 20/58 (34%), Positives = 29/58 (50%), Gaps = 2/58 (3%)

Query: 791 ADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIV--DDLDESCMETLDPKFRTLAEI 846
           AD D   P  D + IY +EG GS  GS+          DLD   ++   P+F+ LA++
Sbjct: 728 ADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADL 785


>gi|221316595 cadherin 17 precursor [Homo sapiens]
          Length = 832

 Score =  176 bits (445), Expect = 1e-43
 Identities = 155/574 (27%), Positives = 247/574 (43%), Gaps = 65/574 (11%)

Query: 93  DRPPYGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDIND 152
           ++ P   F+I+ + G+I +T  +DRE    ++ Y  A +  G+ L  PLE+ VKV DIND
Sbjct: 277 EKLPRFPFSID-QEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDIND 335

Query: 153 NAPVFSQSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPM---F 209
           N P     V    ++EN      +  L A D DEEN  NS + Y+IV Q P   PM   F
Sbjct: 336 NPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPK-LPMDGLF 394

Query: 210 ILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTL 269
           ++  Y G +      L ++    YNL +  SD+D       + C  +I V+D+ND  P  
Sbjct: 395 LIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKD-----FKTLCFVQINVIDINDQIPIF 449

Query: 270 EKTSYS--ASIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTN 327
           EK+ Y      E+  + S ++ +QA D DE  T +    Y I+ G+      + TDP TN
Sbjct: 450 EKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTN 509

Query: 328 EGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSV---ASQFQMHPTPVRIQVVDVREGPA 384
            G + + K LD+E A    +    +N     + V   AS F        + V DV E P 
Sbjct: 510 TGYVIIKKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSF----AKFTLIVTDVNEAPQ 565

Query: 385 FHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTG 444
           F        V E +     +   +G  TA D +      D+ Y +  D   WLKID  TG
Sbjct: 566 FSQHVFQAKVSEDV----AIGTKVGNVTAKDPE----GLDISYSLRGDTRGWLKIDHVTG 617

Query: 445 EIQFSREFDKKSKYIINGIYTAEILAID-DGSGKTATGTICIEVPDINDYCPNIFPERRT 503
           EI      D+++       Y  +++A +  GS  ++     + + D+ND  P +  +   
Sbjct: 618 EIFSVAPLDREA----GSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTG 673

Query: 504 IC----IDSPSVLI----SVNEHSYGSP-FTFCVVDEPPGIADMWDVRSTNATSAILTAK 554
           +     + +P  LI      ++H +  P FTF +      + + W+V   N T A L+ +
Sbjct: 674 LFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSL--GSGSLQNDWEVSKINGTHARLSTR 731

Query: 555 QV-LSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTY 613
                   Y + I + D      E    + +  C C                  + G  +
Sbjct: 732 HTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSC------------------VEGSCF 773

Query: 614 GPVTEDQAGVSNVGL--GPAGIGMMVLGILLLIL 645
            P    Q G+  VG+  G     ++V+GI+L ++
Sbjct: 774 RPAGH-QTGIPTVGMAVGILLTTLLVIGIILAVV 806



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 118/450 (26%), Positives = 189/450 (42%), Gaps = 59/450 (13%)

Query: 99  VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
           +F I  R G +     +DRE      +   AL++ G  +E P+ + +KV DINDN P F 
Sbjct: 69  IFVIE-REGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFL 127

Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEP--SGAPMFILNRYTG 216
           QS Y  S+ +NS      + + ATD D+    N ++ Y+IV Q P  +    F +N  TG
Sbjct: 128 QSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTG 187

Query: 217 EVCTM---SSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTS 273
            +      S  L+  ++  YNLV+   D  G ++  +S  D     + V +N   + K  
Sbjct: 188 AISLTREGSQELNPAKNPSYNLVISVKDMGGQSE--NSFSDTTSVDIIVTEN---IWKAP 242

Query: 274 YSASIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKV 333
               + EN      I++  +  ++ G     AQY ++       F    D    EG + V
Sbjct: 243 KPVEMVENSTDPHPIKITQVRWNDPG-----AQYSLVDKEKLPRFPFSID---QEGDIYV 294

Query: 334 VKMLDYEQAPNIQLSIGVKNQADFHYSVASQFQ----MHPTPVRIQVVDVREGPAFHPST 389
            + LD E+             A   Y+VA         +P  + ++V D+ + P   PS 
Sbjct: 295 TQPLDREE-----------KDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSP 343

Query: 390 M-AFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATD-VRYIIGHDA------GSWLKIDS 441
           +  F V+E    +  L   +GT TA D D  N A   + Y I          G +L I +
Sbjct: 344 VTVFEVQE----NERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFL-IQT 398

Query: 442 RTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPE- 500
             G +Q +++  KK       +     + + D   KT    + I V DIND  P IF + 
Sbjct: 399 YAGMLQLAKQSLKKQDTPQYNL----TIEVSDKDFKTLC-FVQINVIDINDQIP-IFEKS 452

Query: 501 ---RRTICIDS--PSVLISVNEHSYGSPFT 525
                T+  D+   S ++++       PFT
Sbjct: 453 DYGNLTLAEDTNIGSTILTIQATDADEPFT 482


>gi|221316593 cadherin 17 precursor [Homo sapiens]
          Length = 832

 Score =  176 bits (445), Expect = 1e-43
 Identities = 155/574 (27%), Positives = 247/574 (43%), Gaps = 65/574 (11%)

Query: 93  DRPPYGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDIND 152
           ++ P   F+I+ + G+I +T  +DRE    ++ Y  A +  G+ L  PLE+ VKV DIND
Sbjct: 277 EKLPRFPFSID-QEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDIND 335

Query: 153 NAPVFSQSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPM---F 209
           N P     V    ++EN      +  L A D DEEN  NS + Y+IV Q P   PM   F
Sbjct: 336 NPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPK-LPMDGLF 394

Query: 210 ILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTL 269
           ++  Y G +      L ++    YNL +  SD+D       + C  +I V+D+ND  P  
Sbjct: 395 LIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKD-----FKTLCFVQINVIDINDQIPIF 449

Query: 270 EKTSYS--ASIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTN 327
           EK+ Y      E+  + S ++ +QA D DE  T +    Y I+ G+      + TDP TN
Sbjct: 450 EKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTN 509

Query: 328 EGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSV---ASQFQMHPTPVRIQVVDVREGPA 384
            G + + K LD+E A    +    +N     + V   AS F        + V DV E P 
Sbjct: 510 TGYVIIKKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSF----AKFTLIVTDVNEAPQ 565

Query: 385 FHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTG 444
           F        V E +     +   +G  TA D +      D+ Y +  D   WLKID  TG
Sbjct: 566 FSQHVFQAKVSEDV----AIGTKVGNVTAKDPE----GLDISYSLRGDTRGWLKIDHVTG 617

Query: 445 EIQFSREFDKKSKYIINGIYTAEILAID-DGSGKTATGTICIEVPDINDYCPNIFPERRT 503
           EI      D+++       Y  +++A +  GS  ++     + + D+ND  P +  +   
Sbjct: 618 EIFSVAPLDREA----GSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTG 673

Query: 504 IC----IDSPSVLI----SVNEHSYGSP-FTFCVVDEPPGIADMWDVRSTNATSAILTAK 554
           +     + +P  LI      ++H +  P FTF +      + + W+V   N T A L+ +
Sbjct: 674 LFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSL--GSGSLQNDWEVSKINGTHARLSTR 731

Query: 555 QV-LSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTY 613
                   Y + I + D      E    + +  C C                  + G  +
Sbjct: 732 HTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSC------------------VEGSCF 773

Query: 614 GPVTEDQAGVSNVGL--GPAGIGMMVLGILLLIL 645
            P    Q G+  VG+  G     ++V+GI+L ++
Sbjct: 774 RPAGH-QTGIPTVGMAVGILLTTLLVIGIILAVV 806



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 118/450 (26%), Positives = 189/450 (42%), Gaps = 59/450 (13%)

Query: 99  VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
           +F I  R G +     +DRE      +   AL++ G  +E P+ + +KV DINDN P F 
Sbjct: 69  IFVIE-REGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFL 127

Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEP--SGAPMFILNRYTG 216
           QS Y  S+ +NS      + + ATD D+    N ++ Y+IV Q P  +    F +N  TG
Sbjct: 128 QSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTG 187

Query: 217 EVCTM---SSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTS 273
            +      S  L+  ++  YNLV+   D  G ++  +S  D     + V +N   + K  
Sbjct: 188 AISLTREGSQELNPAKNPSYNLVISVKDMGGQSE--NSFSDTTSVDIIVTEN---IWKAP 242

Query: 274 YSASIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKV 333
               + EN      I++  +  ++ G     AQY ++       F    D    EG + V
Sbjct: 243 KPVEMVENSTDPHPIKITQVRWNDPG-----AQYSLVDKEKLPRFPFSID---QEGDIYV 294

Query: 334 VKMLDYEQAPNIQLSIGVKNQADFHYSVASQFQ----MHPTPVRIQVVDVREGPAFHPST 389
            + LD E+             A   Y+VA         +P  + ++V D+ + P   PS 
Sbjct: 295 TQPLDREE-----------KDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSP 343

Query: 390 M-AFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATD-VRYIIGHDA------GSWLKIDS 441
           +  F V+E    +  L   +GT TA D D  N A   + Y I          G +L I +
Sbjct: 344 VTVFEVQE----NERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFL-IQT 398

Query: 442 RTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPE- 500
             G +Q +++  KK       +     + + D   KT    + I V DIND  P IF + 
Sbjct: 399 YAGMLQLAKQSLKKQDTPQYNL----TIEVSDKDFKTLC-FVQINVIDINDQIP-IFEKS 452

Query: 501 ---RRTICIDS--PSVLISVNEHSYGSPFT 525
                T+  D+   S ++++       PFT
Sbjct: 453 DYGNLTLAEDTNIGSTILTIQATDADEPFT 482


>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
          Length = 789

 Score =  174 bits (442), Expect = 3e-43
 Identities = 181/686 (26%), Positives = 301/686 (43%), Gaps = 65/686 (9%)

Query: 44  VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTI 102
           +RR KR W+       E    +    + K+ +D +     + Y ++G G       +F I
Sbjct: 48  LRRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAG----SLFVI 103

Query: 103 NPRTGEINITSVVDREITPLFLIYCRALNSR-GEDLERPLELRVKVMDINDNAPVFSQSV 161
           +  TG+I+    +DRE   L+++  +A++ + G  +E   E  +K+ DINDN P F++ +
Sbjct: 104 DENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDL 163

Query: 162 YTASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCT 220
           YTAS+ E S   T V+++ ATDAD+ N+ NS K+ Y I+     G P F ++  +G + T
Sbjct: 164 YTASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSIL----QGQPYFSVDPESGIIKT 219

Query: 221 MSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEE 280
               + RE    Y +V++  D  G   GLS      I + DVN+N P   +++Y  +  E
Sbjct: 220 ALPDMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPE 279

Query: 281 NC-LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDY 339
           +  L + L R++A D D    +N   +Y I  G+  + FD+ TD  T EGI+ V + LD+
Sbjct: 280 SVPLGTHLGRIKANDPDV--GENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDF 337

Query: 340 EQAPNIQLSIGVKN-QADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
           E      L +   N   D  +     F+     V+I V D+ E P F   +    V E +
Sbjct: 338 ENQMLYTLRVDASNTHPDPRFLHLGPFK-DTAVVKISVEDIDEPPVFTKVSYLIEVDEDV 396

Query: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDKKS 456
           K  S    ++G  TA D D  N    ++Y +    D      I S  G I   +  D++S
Sbjct: 397 KEGS----IIGQVTAYDPDARNNL--IKYSVDRHTDMDRIFGIHSENGSIFTLKALDRES 450

Query: 457 KYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDS--PSVLIS 514
               N   TA  +   +   +++   + I + DIND+ P       T   ++  P  LI 
Sbjct: 451 SPWHNITVTATEI---NNPKQSSHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQ 507

Query: 515 V------NEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLS---PGFYEIP 565
                  ++   G  F F  V E     +   V + + T+ I+T K   S      Y +P
Sbjct: 508 TVSVMDKDDPPRGHKFFFEPVPEFTLNPNFTIVDNKDNTAGIMTRKDGYSRNKMSTYLLP 567

Query: 566 ILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSN 625
           IL+ D+          + +  C C DN   + S  A                  +A + +
Sbjct: 568 ILIFDNDYPIQSSTGTLTIRVCAC-DNQGNMQSCTA------------------EALILS 608

Query: 626 VGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEG 685
            GL    +  ++L +L+L++  ++L     +QR+ E L      V +     + ++  EG
Sbjct: 609 AGLSTGALVAILLCVLILLIL-VVLFAALKRQRKKEPLIISKDDVRDN----IVTYNDEG 663

Query: 686 AHPEDRDVSNICAPMTASNTQDRMDS 711
              ED    +I    T  N + R DS
Sbjct: 664 GGEEDTQAFDI---GTLRNPEAREDS 686


>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
          Length = 788

 Score =  174 bits (440), Expect = 5e-43
 Identities = 168/636 (26%), Positives = 280/636 (44%), Gaps = 61/636 (9%)

Query: 44  VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTI 102
           + RQKR W+       E    S    + K+ SD +     + Y +SG G       +F I
Sbjct: 49  LHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGT----LFII 104

Query: 103 NPRTGEINITSVVDREITPLFLIYCRALNSRG-EDLERPLELRVKVMDINDNAPVFSQSV 161
           + +TG+I+ T  +DRE    + +  +A+N R    +E   E  +K+ DINDN P F + +
Sbjct: 105 DEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEI 164

Query: 162 YTASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCT 220
           YTAS+ E S   T VV++ ATDAD+ ++ NS ++ Y I+     G P F +   TG + T
Sbjct: 165 YTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSIL----QGQPYFSVEPETGIIRT 220

Query: 221 MSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTL-EKTSYSASIE 279
               ++RE    Y +V++  D  G   GLS      I + DVNDN P   + T +   +E
Sbjct: 221 ALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLE 280

Query: 280 ENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDY 339
            + + + +  ++A D D     N   +Y I+ G+  + FDI T+  T EGI+ V K LDY
Sbjct: 281 SSPVGTAIGSVKATDADT--GKNAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDY 338

Query: 340 EQAPNIQLSIGVKN-QADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
           E      L +  +N   D  +     F+   T V+I + DV E P F  S+  F V E I
Sbjct: 339 ESRRLYTLKVEAENTHVDPRFYYLGPFK-DTTIVKISIEDVDEPPVFSRSSYLFEVHEDI 397

Query: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDKK- 455
           +    +  ++GT  A D D  + ++ +R+ +    D      I S  G +  S+  D++ 
Sbjct: 398 E----VGTIIGTVMARDPD--SISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDREL 451

Query: 456 SKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDS--PSVLI 513
           S++    +  AEI    +   +T    + + + D+ND  P       T   ++  P  LI
Sbjct: 452 SQWHNLTVIAAEI----NNPKETTRVAVFVRILDVNDNAPQFAVFYDTFVCENARPGQLI 507

Query: 514 SV------NEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSP---GFYEI 564
                   ++   G  F F +    P         + + T+ ILT K   +      Y +
Sbjct: 508 QTISAVDKDDPLGGQKFFFSLAAVNPNFTVQ---DNEDNTARILTRKNGFNRHEISTYLL 564

Query: 565 PILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVS 624
           P+++ D+          + +  C CD         A  +                 AG+S
Sbjct: 565 PVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLL--------------PAGLS 610

Query: 625 NVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP 660
              L    I +++  I+LL++  L   L   ++++P
Sbjct: 611 TGAL----IAILLCIIILLVIVVLFAALKRQRKKEP 642


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,575,950
Number of Sequences: 37866
Number of extensions: 1926777
Number of successful extensions: 7042
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 192
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 4150
Number of HSP's gapped (non-prelim): 902
length of query: 1040
length of database: 18,247,518
effective HSP length: 112
effective length of query: 928
effective length of database: 14,006,526
effective search space: 12998056128
effective search space used: 12998056128
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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