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Search of human proteins with 29789283
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29789283 WD repeat domain 75 [Homo sapiens]
(830 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29789283 WD repeat domain 75 [Homo sapiens] 1691 0.0
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 56 2e-07
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 52 2e-06
gi|19913369 transducin beta-like 3 [Homo sapiens] 49 1e-05
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 48 3e-05
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 48 4e-05
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 48 4e-05
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 47 7e-05
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 47 7e-05
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 47 7e-05
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 47 7e-05
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 47 1e-04
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 47 1e-04
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 47 1e-04
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 46 1e-04
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 45 3e-04
gi|16554629 WD repeat domain 5 [Homo sapiens] 45 3e-04
gi|16554627 WD repeat domain 5 [Homo sapiens] 45 3e-04
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 45 4e-04
gi|34996489 pleckstrin homology domain interacting protein [Homo... 44 5e-04
gi|55769546 PAK1 interacting protein 1 [Homo sapiens] 44 6e-04
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 43 0.001
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 43 0.001
gi|23199987 WD repeat domain 5B [Homo sapiens] 43 0.001
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 43 0.001
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 43 0.001
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 43 0.001
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 43 0.001
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 43 0.001
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 43 0.001
>gi|29789283 WD repeat domain 75 [Homo sapiens]
Length = 830
Score = 1691 bits (4379), Expect = 0.0
Identities = 830/830 (100%), Positives = 830/830 (100%)
Query: 1 MVEEENIRVVRCGGSELNFRRAVFSADSKYIFCVSGDFVKVYSTVTEECVHILHGHRNLV 60
MVEEENIRVVRCGGSELNFRRAVFSADSKYIFCVSGDFVKVYSTVTEECVHILHGHRNLV
Sbjct: 1 MVEEENIRVVRCGGSELNFRRAVFSADSKYIFCVSGDFVKVYSTVTEECVHILHGHRNLV 60
Query: 61 TGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVN 120
TGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVN
Sbjct: 61 TGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVN 120
Query: 121 KEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSV 180
KEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSV
Sbjct: 121 KEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSV 180
Query: 181 YFFKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYT 240
YFFKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYT
Sbjct: 181 YFFKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYT 240
Query: 241 YTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSP 300
YTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSP
Sbjct: 241 YTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSP 300
Query: 301 AGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQF 360
AGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQF
Sbjct: 301 AGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQF 360
Query: 361 YSLQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMK 420
YSLQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMK
Sbjct: 361 YSLQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMK 420
Query: 421 LWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDDSD 480
LWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDDSD
Sbjct: 421 LWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDDSD 480
Query: 481 IYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAG 540
IYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAG
Sbjct: 481 IYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAG 540
Query: 541 KIRHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQ 600
KIRHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQ
Sbjct: 541 KIRHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQ 600
Query: 601 SSVGSDLFVFKPSEPRPLYIQKGISREKVQWGVFVPRDVPESFTSEAYQWLNRSQFYFLT 660
SSVGSDLFVFKPSEPRPLYIQKGISREKVQWGVFVPRDVPESFTSEAYQWLNRSQFYFLT
Sbjct: 601 SSVGSDLFVFKPSEPRPLYIQKGISREKVQWGVFVPRDVPESFTSEAYQWLNRSQFYFLT 660
Query: 661 KSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQ 720
KSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQ
Sbjct: 661 KSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQ 720
Query: 721 LPLTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESE 780
LPLTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESE
Sbjct: 721 LPLTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESE 780
Query: 781 DSDEENDFTEKVQDTSNTGLGEDIIHQLSKSEEKELRKFRKIDYSWIAAL 830
DSDEENDFTEKVQDTSNTGLGEDIIHQLSKSEEKELRKFRKIDYSWIAAL
Sbjct: 781 DSDEENDFTEKVQDTSNTGLGEDIIHQLSKSEEKELRKFRKIDYSWIAAL 830
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 55.8 bits (133), Expect = 2e-07
Identities = 72/295 (24%), Positives = 114/295 (38%), Gaps = 26/295 (8%)
Query: 27 DSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLW 85
+ +Y+ S D V+++ T C IL GH VT ++ + LYS S D TIK+W
Sbjct: 215 ECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG--LLYSASQDRTIKVW 272
Query: 86 DYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAK 145
DG+L +T + H + A + + + V+ + + S QE++ +
Sbjct: 273 RAHDGVLCRTL----QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKER 328
Query: 146 ELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYFFKKKTTSRFTLSSSRNKKHAKNN 205
LS Q P+ + G++ + F S KK T + N+
Sbjct: 329 ALSRYNLVRGQGPERLVSGSDDFTL-----FLWSPAEDKKPLTRMTGHQALINQ------ 377
Query: 206 FTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTY-TCLHWHHDMVMDLAFSVTGTSLL 264
V P +AS D I+LW D + Y L H V +A+S L+
Sbjct: 378 ---VLFSPDSRIVASASFDKSIKLW----DGRTGKYLASLRGHVAAVYQIAWSADSRLLV 430
Query: 265 SGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHR 319
SG +S L W +K LP + + SP G + D + I R
Sbjct: 431 SGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 485
Score = 34.3 bits (77), Expect = 0.49
Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 4 EENIRVVRCGGSELNFRRAVFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTG 62
E+ + R G + + +FS DS+ + S D +K++ T + + L GH V
Sbjct: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
Query: 63 IQLNPNNHLQLYSCSLDGTIKLWD 86
I + ++ L L S S D T+K+WD
Sbjct: 420 IAWSADSRL-LVSGSSDSTLKVWD 442
Score = 33.5 bits (75), Expect = 0.83
Identities = 21/73 (28%), Positives = 33/73 (45%), Gaps = 3/73 (4%)
Query: 209 VACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGR 268
VA PT +ASG D +R W + +T H V+ +++S G L SG +
Sbjct: 120 VAFSPTGKYLASGSGDTTVRFWDLSTETPHFT---CKGHRHWVLSISWSPDGRKLASGCK 176
Query: 269 ESVLVEWRDATEK 281
++ W +T K
Sbjct: 177 NGQILLWDPSTGK 189
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 52.4 bits (124), Expect = 2e-06
Identities = 63/316 (19%), Positives = 136/316 (43%), Gaps = 20/316 (6%)
Query: 10 VRCGGSELNFRRAVFSADSKYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNN 69
+ GG + R FS+D+ + + D +K+++ T +C+ + L + P +
Sbjct: 409 ITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFV--PGD 466
Query: 70 HLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDS-VFVIVNKEKP-DIF 127
Q+ + G ++L+D G L++T + AL++++ + D FV +K +
Sbjct: 467 R-QVVIGTKTGKLQLYDLASGNLLET--IDAHDGALWSMSLSPDQRGFVTGGADKSVKFW 523
Query: 128 QLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFG-NEGVYVAAVREFYLSVYFFKKK 186
VK S+ + + K+ + +++ C+++ N+ + ++ + + +++
Sbjct: 524 DFELVKDENSTQKRLSVKQTRTL--QLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYV--- 578
Query: 187 TTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHW 246
T +F LS +K C+ IA+G D +++W + D + L
Sbjct: 579 DTLKFFLSLYGHKLPV----ICMDISHDGALIATGSADRNVKIWGLDFGD---CHKSLFA 631
Query: 247 HHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFC 306
H D VM L F + G++ + +W ++ + L I ++VSP+GD
Sbjct: 632 HDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVV 691
Query: 307 TSHSDNKIIIIHRNLE 322
+S D + + R E
Sbjct: 692 SSSHDKSLRLWERTRE 707
Score = 35.0 bits (79), Expect = 0.29
Identities = 33/161 (20%), Positives = 62/161 (38%), Gaps = 5/161 (3%)
Query: 203 KNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTS 262
K TC+ P +A G+ DG IR++ + T+ + H + L + G
Sbjct: 65 KQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTF---NGHKAAITTLKYDQLGGR 121
Query: 263 LLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLE 322
L SG +++ ++ W E L I +L TS D ++ +L+
Sbjct: 122 LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDT--MVKWWDLD 179
Query: 323 ASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSL 363
+ +V R+ GL++ K L+ L+ + +
Sbjct: 180 TQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 49.3 bits (116), Expect = 1e-05
Identities = 67/300 (22%), Positives = 119/300 (39%), Gaps = 25/300 (8%)
Query: 27 DSKYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWD 86
DS + + +KV+ T C ILHGH ++V + + L SC+ D ++++W
Sbjct: 347 DSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWL-FASCAKDQSVRIWR 404
Query: 87 YIDGILIKTFIVGC-KLHALFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAK 145
+ G H++ T+ + +V + +L LPK+ + A
Sbjct: 405 MNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWP--LPKALLSKNTAP 462
Query: 146 ELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYFFKKKTTSRFTLSSSRNK---KHA 202
+ +L + +C V +A + L + +T + L +
Sbjct: 463 DNGPILLQAQTTQRCHDKDINSVAIAPNDK--LLATGSQDRTAKLWALPQCQLLGVFSGH 520
Query: 203 KNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCL---HWHHDMVMDLAFSVT 259
+ CV P + +A+ DG I+LW ++CL H V+ +AF
Sbjct: 521 RRGLWCVQFSPMDQVLATASADGTIKLW------ALQDFSCLKTFEGHDASVLKVAFVSR 574
Query: 260 GTSLLSGGRESVLVEWRDATEKNKEFLPRLGA---TIEHISVSPAGDLFCTSHSDNKIII 316
GT LLS G + ++ W T KN E + L A + + S D T SD+++I+
Sbjct: 575 GTQLLSSGSDGLVKLW---TIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVIL 631
Score = 36.2 bits (82), Expect = 0.13
Identities = 23/69 (33%), Positives = 32/69 (46%), Gaps = 5/69 (7%)
Query: 209 VACHP--TEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSG 266
VA HP T + S D IR+W + L H+ V LAFS G ++LS
Sbjct: 157 VAFHPDPTRLLLFSSATDAAIRVWSL---QDRSCLAVLTAHYSAVTSLAFSADGHTMLSS 213
Query: 267 GRESVLVEW 275
GR+ + + W
Sbjct: 214 GRDKICIIW 222
Score = 35.0 bits (79), Expect = 0.29
Identities = 25/87 (28%), Positives = 43/87 (49%), Gaps = 4/87 (4%)
Query: 11 RCGGSELNFRRAVFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNN 69
RC ++N + + K + S D K+++ + + + GHR + +Q +P +
Sbjct: 476 RCHDKDIN--SVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMD 533
Query: 70 HLQLYSCSLDGTIKLWDYIDGILIKTF 96
+ L + S DGTIKLW D +KTF
Sbjct: 534 QV-LATASADGTIKLWALQDFSCLKTF 559
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 48.1 bits (113), Expect = 3e-05
Identities = 39/136 (28%), Positives = 58/136 (42%), Gaps = 5/136 (3%)
Query: 208 CVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGG 267
CV HP + +A+G D +RLW + +T H V+ LAFS G L S G
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFT---GHRGPVLSLAFSPNGKYLASAG 487
Query: 268 RESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIH-RNLEASAV 326
+ L W A+ + L I ++ SP L ++ DN + + RN SA
Sbjct: 488 EDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAP 547
Query: 327 IQGLVKDR-SIFTGLM 341
G + ++TG M
Sbjct: 548 ADGSSSELVGVYTGQM 563
Score = 36.2 bits (82), Expect = 0.13
Identities = 24/72 (33%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 24 FSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTI 82
F +S Y+ S D V+++S V + GHR V + +PN L S D +
Sbjct: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKY-LASAGEDQRL 492
Query: 83 KLWDYIDGILIK 94
KLWD G L K
Sbjct: 493 KLWDLASGTLYK 504
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 47.8 bits (112), Expect = 4e-05
Identities = 61/262 (23%), Positives = 105/262 (40%), Gaps = 22/262 (8%)
Query: 24 FSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTI 82
F K + S D +K++ EC+ +HGH + V+ + + PN + S S D TI
Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGD-HIVSASRDKTI 216
Query: 83 KLWDYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEV 142
K+W+ G +KTF G + + ++ + + Q V V + + +
Sbjct: 217 KMWEVQTGYCVKTF-TGHREWVRMVRPNQDGTLIASCSND-----QTVRVWVVATKECKA 270
Query: 143 EAKELSFVLDYINQSPKCI------AFGNEGVYVAAVREFYLSVYFFKKKTTSRFTLSSS 196
E +E V++ I+ +P+ A G+E F LS + KT + +S+
Sbjct: 271 ELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS--GSRDKTIKMWDVSTG 328
Query: 197 ---RNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMD 253
N V H I S D +R+W Y +K+ T L+ H V
Sbjct: 329 MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWD--YKNKRCMKT-LNAHEHFVTS 385
Query: 254 LAFSVTGTSLLSGGRESVLVEW 275
L F T +++G + + W
Sbjct: 386 LDFHKTAPYVVTGSVDQTVKVW 407
Score = 33.1 bits (74), Expect = 1.1
Identities = 62/252 (24%), Positives = 89/252 (35%), Gaps = 69/252 (27%)
Query: 51 HILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQ 110
+ L GHR+ VT + +P + + S S D TIK+WDY G + TL
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMV-SASEDATIKVWDYETGDFER------------TLKG 148
Query: 111 AEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYV 170
DSV DI S KL S S ++ K F Q +CI
Sbjct: 149 HTDSV--------QDISFDHSGKLLASCSADMTIKLWDF------QGFECI--------- 185
Query: 171 AAVREFYLSVYFFKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLW 230
R +N + VA P D I S D I++W
Sbjct: 186 --------------------------RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219
Query: 231 --RNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPR 288
+ Y K +T H + V + + GT + S + + W AT++ K L
Sbjct: 220 EVQTGYCVKTFT-----GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE 274
Query: 289 LGATIEHISVSP 300
+E IS +P
Sbjct: 275 HEHVVECISWAP 286
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 47.8 bits (112), Expect = 4e-05
Identities = 51/222 (22%), Positives = 98/222 (44%), Gaps = 25/222 (11%)
Query: 16 ELNFRRAVFSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLY 74
+L R A F A ++ + D ++V++ T E VH+ H + + I ++P L
Sbjct: 57 DLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILT 116
Query: 75 SCSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSVKL 134
S S D IKLWD+ G H + + +++N + D Q S L
Sbjct: 117 S-SDDMLIKLWDWDKKWSCSQVFEG---HTHYVMQ-------IVINPK--DNNQFASASL 163
Query: 135 PKSSSQ-EVEAKELSFVLDYINQSPKCIAF---GNEGVYVAAVREFYLSVYFFKKKTTSR 190
++ ++ + +F L+ + CI + G++ ++ + + ++ ++ KT +
Sbjct: 164 DRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQ 223
Query: 191 FTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRN 232
TL HA+N +C + HP I +G DG +R+W +
Sbjct: 224 -TLEG-----HAQN-VSCASFHPELPIIITGSEDGTVRIWHS 258
Score = 30.8 bits (68), Expect = 5.4
Identities = 30/150 (20%), Positives = 57/150 (38%), Gaps = 28/150 (18%)
Query: 377 QEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTK 436
Q + + + + + A F NW+ T ++Q++++ YN + +
Sbjct: 47 QTLVKTFEVCDLPVRAAKFVARKNWVVTGAD--------DMQIRVFNYNTLERVHMFEA- 97
Query: 437 INMPHEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSY 496
H D I C A QP ++T+S D K+W D KK W+C V
Sbjct: 98 ----HSDYIR----CIAVHPTQPFILTSSDDMLIKLW------DWDKK---WSCSQVFEG 140
Query: 497 HKYQATNCCFS--EDGSLLAVSFEEIVTIW 524
H + + ++ + S + + +W
Sbjct: 141 HTHYVMQIVINPKDNNQFASASLDRTIKVW 170
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 47.0 bits (110), Expect = 7e-05
Identities = 24/66 (36%), Positives = 39/66 (59%), Gaps = 4/66 (6%)
Query: 24 FSADSKYIFCVSGD---FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDG 80
F+ S ++ +G F+K++ +EC + + GH N V + +P++ L L SCS DG
Sbjct: 707 FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKL-LASCSADG 765
Query: 81 TIKLWD 86
T+KLWD
Sbjct: 766 TLKLWD 771
Score = 42.7 bits (99), Expect = 0.001
Identities = 26/75 (34%), Positives = 43/75 (57%), Gaps = 4/75 (5%)
Query: 24 FSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTI 82
F+AD K + S D ++V++ ++C+ L GH+ V +L N+ +L S S DGT+
Sbjct: 968 FTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNS--RLLSWSFDGTV 1024
Query: 83 KLWDYIDGILIKTFI 97
K+W+ I G K F+
Sbjct: 1025 KVWNIITGNKEKDFV 1039
Score = 37.4 bits (85), Expect = 0.058
Identities = 24/65 (36%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 24 FSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQL-NPNNHLQLYSCSLDGT 81
FS D ++I S D VK+++++T E VH H V N ++HL L + S D
Sbjct: 665 FSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 724
Query: 82 IKLWD 86
+KLWD
Sbjct: 725 LKLWD 729
Score = 33.1 bits (74), Expect = 1.1
Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 7/95 (7%)
Query: 441 HEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQ 500
H C+ C+A + L T +G ++W +++ ++ A + + H
Sbjct: 1083 HNGCVR----CSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAP--LSEEGAATHGGW 1136
Query: 501 ATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTF 535
T+ CFS DG +L +S + W+ VT E TF
Sbjct: 1137 VTDLCFSPDGKML-ISAGGYIKWWNVVTGESSQTF 1170
Score = 32.3 bits (72), Expect = 1.9
Identities = 26/100 (26%), Positives = 41/100 (41%), Gaps = 11/100 (11%)
Query: 208 CVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTC-------LHWHHDMVMDLAFSVTG 260
C A +A+G +G+IR+W + + + C H V DL FS G
Sbjct: 1089 CSAFSVDSTLLATGDDNGEIRIWN--VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDG 1146
Query: 261 TSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSP 300
L+S G + W T ++ + G ++ I VSP
Sbjct: 1147 KMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1184
Score = 30.4 bits (67), Expect = 7.0
Identities = 19/76 (25%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Query: 22 AVFSADSKYIF-CVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDG 80
A FS D + I C + ++V+ T E + + H + V + ++ + +CS+D
Sbjct: 621 ACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF-IATCSVDK 679
Query: 81 TIKLWDYIDGILIKTF 96
+K+W+ + G L+ T+
Sbjct: 680 KVKIWNSMTGELVHTY 695
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 47.0 bits (110), Expect = 7e-05
Identities = 24/66 (36%), Positives = 39/66 (59%), Gaps = 4/66 (6%)
Query: 24 FSADSKYIFCVSGD---FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDG 80
F+ S ++ +G F+K++ +EC + + GH N V + +P++ L L SCS DG
Sbjct: 707 FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKL-LASCSADG 765
Query: 81 TIKLWD 86
T+KLWD
Sbjct: 766 TLKLWD 771
Score = 42.7 bits (99), Expect = 0.001
Identities = 26/75 (34%), Positives = 43/75 (57%), Gaps = 4/75 (5%)
Query: 24 FSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTI 82
F+AD K + S D ++V++ ++C+ L GH+ V +L N+ +L S S DGT+
Sbjct: 1011 FTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNS--RLLSWSFDGTV 1067
Query: 83 KLWDYIDGILIKTFI 97
K+W+ I G K F+
Sbjct: 1068 KVWNIITGNKEKDFV 1082
Score = 37.4 bits (85), Expect = 0.058
Identities = 24/65 (36%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 24 FSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQL-NPNNHLQLYSCSLDGT 81
FS D ++I S D VK+++++T E VH H V N ++HL L + S D
Sbjct: 665 FSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 724
Query: 82 IKLWD 86
+KLWD
Sbjct: 725 LKLWD 729
Score = 33.1 bits (74), Expect = 1.1
Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 7/95 (7%)
Query: 441 HEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQ 500
H C+ C+A + L T +G ++W +++ ++ A + + H
Sbjct: 1126 HNGCVR----CSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAP--LSEEGAATHGGW 1179
Query: 501 ATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTF 535
T+ CFS DG +L +S + W+ VT E TF
Sbjct: 1180 VTDLCFSPDGKML-ISAGGYIKWWNVVTGESSQTF 1213
Score = 32.3 bits (72), Expect = 1.9
Identities = 26/100 (26%), Positives = 41/100 (41%), Gaps = 11/100 (11%)
Query: 208 CVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTC-------LHWHHDMVMDLAFSVTG 260
C A +A+G +G+IR+W + + + C H V DL FS G
Sbjct: 1132 CSAFSVDSTLLATGDDNGEIRIWN--VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDG 1189
Query: 261 TSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSP 300
L+S G + W T ++ + G ++ I VSP
Sbjct: 1190 KMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1227
Score = 30.4 bits (67), Expect = 7.0
Identities = 19/76 (25%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Query: 22 AVFSADSKYIF-CVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDG 80
A FS D + I C + ++V+ T E + + H + V + ++ + +CS+D
Sbjct: 621 ACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF-IATCSVDK 679
Query: 81 TIKLWDYIDGILIKTF 96
+K+W+ + G L+ T+
Sbjct: 680 KVKIWNSMTGELVHTY 695
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 47.0 bits (110), Expect = 7e-05
Identities = 24/66 (36%), Positives = 39/66 (59%), Gaps = 4/66 (6%)
Query: 24 FSADSKYIFCVSGD---FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDG 80
F+ S ++ +G F+K++ +EC + + GH N V + +P++ L L SCS DG
Sbjct: 696 FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKL-LASCSADG 754
Query: 81 TIKLWD 86
T+KLWD
Sbjct: 755 TLKLWD 760
Score = 42.7 bits (99), Expect = 0.001
Identities = 26/75 (34%), Positives = 43/75 (57%), Gaps = 4/75 (5%)
Query: 24 FSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTI 82
F+AD K + S D ++V++ ++C+ L GH+ V +L N+ +L S S DGT+
Sbjct: 957 FTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNS--RLLSWSFDGTV 1013
Query: 83 KLWDYIDGILIKTFI 97
K+W+ I G K F+
Sbjct: 1014 KVWNIITGNKEKDFV 1028
Score = 37.4 bits (85), Expect = 0.058
Identities = 24/65 (36%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 24 FSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQL-NPNNHLQLYSCSLDGT 81
FS D ++I S D VK+++++T E VH H V N ++HL L + S D
Sbjct: 654 FSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 713
Query: 82 IKLWD 86
+KLWD
Sbjct: 714 LKLWD 718
Score = 33.1 bits (74), Expect = 1.1
Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 7/95 (7%)
Query: 441 HEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQ 500
H C+ C+A + L T +G ++W +++ ++ A + + H
Sbjct: 1072 HNGCVR----CSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAP--LSEEGAATHGGW 1125
Query: 501 ATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTF 535
T+ CFS DG +L +S + W+ VT E TF
Sbjct: 1126 VTDLCFSPDGKML-ISAGGYIKWWNVVTGESSQTF 1159
Score = 32.3 bits (72), Expect = 1.9
Identities = 26/100 (26%), Positives = 41/100 (41%), Gaps = 11/100 (11%)
Query: 208 CVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTC-------LHWHHDMVMDLAFSVTG 260
C A +A+G +G+IR+W + + + C H V DL FS G
Sbjct: 1078 CSAFSVDSTLLATGDDNGEIRIWN--VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDG 1135
Query: 261 TSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSP 300
L+S G + W T ++ + G ++ I VSP
Sbjct: 1136 KMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1173
Score = 30.4 bits (67), Expect = 7.0
Identities = 19/76 (25%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Query: 22 AVFSADSKYIF-CVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDG 80
A FS D + I C + ++V+ T E + + H + V + ++ + +CS+D
Sbjct: 610 ACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF-IATCSVDK 668
Query: 81 TIKLWDYIDGILIKTF 96
+K+W+ + G L+ T+
Sbjct: 669 KVKIWNSMTGELVHTY 684
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 47.0 bits (110), Expect = 7e-05
Identities = 24/66 (36%), Positives = 39/66 (59%), Gaps = 4/66 (6%)
Query: 24 FSADSKYIFCVSGD---FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDG 80
F+ S ++ +G F+K++ +EC + + GH N V + +P++ L L SCS DG
Sbjct: 696 FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKL-LASCSADG 754
Query: 81 TIKLWD 86
T+KLWD
Sbjct: 755 TLKLWD 760
Score = 42.7 bits (99), Expect = 0.001
Identities = 26/75 (34%), Positives = 43/75 (57%), Gaps = 4/75 (5%)
Query: 24 FSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTI 82
F+AD K + S D ++V++ ++C+ L GH+ V +L N+ +L S S DGT+
Sbjct: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNS--RLLSWSFDGTV 1056
Query: 83 KLWDYIDGILIKTFI 97
K+W+ I G K F+
Sbjct: 1057 KVWNIITGNKEKDFV 1071
Score = 37.4 bits (85), Expect = 0.058
Identities = 24/65 (36%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 24 FSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQL-NPNNHLQLYSCSLDGT 81
FS D ++I S D VK+++++T E VH H V N ++HL L + S D
Sbjct: 654 FSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 713
Query: 82 IKLWD 86
+KLWD
Sbjct: 714 LKLWD 718
Score = 33.1 bits (74), Expect = 1.1
Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 7/95 (7%)
Query: 441 HEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQ 500
H C+ C+A + L T +G ++W +++ ++ A + + H
Sbjct: 1115 HNGCVR----CSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAP--LSEEGAATHGGW 1168
Query: 501 ATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTF 535
T+ CFS DG +L +S + W+ VT E TF
Sbjct: 1169 VTDLCFSPDGKML-ISAGGYIKWWNVVTGESSQTF 1202
Score = 32.3 bits (72), Expect = 1.9
Identities = 26/100 (26%), Positives = 41/100 (41%), Gaps = 11/100 (11%)
Query: 208 CVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTC-------LHWHHDMVMDLAFSVTG 260
C A +A+G +G+IR+W + + + C H V DL FS G
Sbjct: 1121 CSAFSVDSTLLATGDDNGEIRIWN--VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDG 1178
Query: 261 TSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSP 300
L+S G + W T ++ + G ++ I VSP
Sbjct: 1179 KMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1216
Score = 30.4 bits (67), Expect = 7.0
Identities = 19/76 (25%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Query: 22 AVFSADSKYIF-CVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDG 80
A FS D + I C + ++V+ T E + + H + V + ++ + +CS+D
Sbjct: 610 ACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF-IATCSVDK 668
Query: 81 TIKLWDYIDGILIKTF 96
+K+W+ + G L+ T+
Sbjct: 669 KVKIWNSMTGELVHTY 684
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 46.6 bits (109), Expect = 1e-04
Identities = 32/103 (31%), Positives = 51/103 (49%), Gaps = 7/103 (6%)
Query: 23 VFSADSKYIFCVSGDF---VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLD 79
V+S I VSG ++V+ T C+H L GH++L +G++L N L S + D
Sbjct: 426 VYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN---ILVSGNAD 482
Query: 80 GTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVNKE 122
T+K+WD G ++T K + T Q + FVI + +
Sbjct: 483 STVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN-FVITSSD 524
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/70 (37%), Positives = 38/70 (54%), Gaps = 4/70 (5%)
Query: 27 DSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLW 85
D + + + DF VKV+ TE C+H L GH N V +Q + + + S SLD +I++W
Sbjct: 392 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF---DGIHVVSGSLDTSIRVW 448
Query: 86 DYIDGILIKT 95
D G I T
Sbjct: 449 DVETGNCIHT 458
Score = 38.1 bits (87), Expect = 0.034
Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 6/71 (8%)
Query: 23 VFSADSKYIFCVSGDF---VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLD 79
V+S+ + +SG +KV++ T EC+H L+GH + V + L+ ++ S S D
Sbjct: 306 VWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK---RVVSGSRD 362
Query: 80 GTIKLWDYIDG 90
T+++WD G
Sbjct: 363 ATLRVWDIETG 373
Score = 33.9 bits (76), Expect = 0.64
Identities = 21/57 (36%), Positives = 30/57 (52%), Gaps = 3/57 (5%)
Query: 39 VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKT 95
+KV+S VT +C+ L GH V Q+ N + S S D T+K+W+ G I T
Sbjct: 285 LKVWSAVTGKCLRTLVGHTGGVWSSQMRDN---IIISGSTDRTLKVWNAETGECIHT 338
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 46.6 bits (109), Expect = 1e-04
Identities = 32/103 (31%), Positives = 51/103 (49%), Gaps = 7/103 (6%)
Query: 23 VFSADSKYIFCVSGDF---VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLD 79
V+S I VSG ++V+ T C+H L GH++L +G++L N L S + D
Sbjct: 544 VYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN---ILVSGNAD 600
Query: 80 GTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVNKE 122
T+K+WD G ++T K + T Q + FVI + +
Sbjct: 601 STVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN-FVITSSD 642
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/70 (37%), Positives = 38/70 (54%), Gaps = 4/70 (5%)
Query: 27 DSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLW 85
D + + + DF VKV+ TE C+H L GH N V +Q + + + S SLD +I++W
Sbjct: 510 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF---DGIHVVSGSLDTSIRVW 566
Query: 86 DYIDGILIKT 95
D G I T
Sbjct: 567 DVETGNCIHT 576
Score = 38.1 bits (87), Expect = 0.034
Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 6/71 (8%)
Query: 23 VFSADSKYIFCVSGDF---VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLD 79
V+S+ + +SG +KV++ T EC+H L+GH + V + L+ ++ S S D
Sbjct: 424 VWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK---RVVSGSRD 480
Query: 80 GTIKLWDYIDG 90
T+++WD G
Sbjct: 481 ATLRVWDIETG 491
Score = 33.9 bits (76), Expect = 0.64
Identities = 21/57 (36%), Positives = 30/57 (52%), Gaps = 3/57 (5%)
Query: 39 VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKT 95
+KV+S VT +C+ L GH V Q+ N + S S D T+K+W+ G I T
Sbjct: 403 LKVWSAVTGKCLRTLVGHTGGVWSSQMRDN---IIISGSTDRTLKVWNAETGECIHT 456
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 46.6 bits (109), Expect = 1e-04
Identities = 32/103 (31%), Positives = 51/103 (49%), Gaps = 7/103 (6%)
Query: 23 VFSADSKYIFCVSGDF---VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLD 79
V+S I VSG ++V+ T C+H L GH++L +G++L N L S + D
Sbjct: 464 VYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN---ILVSGNAD 520
Query: 80 GTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVNKE 122
T+K+WD G ++T K + T Q + FVI + +
Sbjct: 521 STVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN-FVITSSD 562
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/70 (37%), Positives = 38/70 (54%), Gaps = 4/70 (5%)
Query: 27 DSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLW 85
D + + + DF VKV+ TE C+H L GH N V +Q + + + S SLD +I++W
Sbjct: 430 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF---DGIHVVSGSLDTSIRVW 486
Query: 86 DYIDGILIKT 95
D G I T
Sbjct: 487 DVETGNCIHT 496
Score = 38.1 bits (87), Expect = 0.034
Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 6/71 (8%)
Query: 23 VFSADSKYIFCVSGDF---VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLD 79
V+S+ + +SG +KV++ T EC+H L+GH + V + L+ ++ S S D
Sbjct: 344 VWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK---RVVSGSRD 400
Query: 80 GTIKLWDYIDG 90
T+++WD G
Sbjct: 401 ATLRVWDIETG 411
Score = 33.9 bits (76), Expect = 0.64
Identities = 21/57 (36%), Positives = 30/57 (52%), Gaps = 3/57 (5%)
Query: 39 VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKT 95
+KV+S VT +C+ L GH V Q+ N + S S D T+K+W+ G I T
Sbjct: 323 LKVWSAVTGKCLRTLVGHTGGVWSSQMRDN---IIISGSTDRTLKVWNAETGECIHT 376
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 46.2 bits (108), Expect = 1e-04
Identities = 57/261 (21%), Positives = 105/261 (40%), Gaps = 31/261 (11%)
Query: 18 NFRRAVFSADSKYIFCVSGDFVKV--YSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYS 75
N V S + GD +V +S C+ L GH + V ++LN L + +
Sbjct: 22 NVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL-IVA 80
Query: 76 CSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSVKLP 135
S G+I++WD +++T ++G K + + +L FV + +I
Sbjct: 81 GSQSGSIRVWDLEAAKILRT-LMGHKAN-ICSLDFHPYGEFVASGSQDTNI--------- 129
Query: 136 KSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYFFKKKTTSRFTLSS 195
++ K F +Q+ +C+ F +G ++A+ + + T + L++
Sbjct: 130 --KLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDH---------TVKLWDLTA 178
Query: 196 SRNKKHAKNN---FTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVM 252
+ + V HP E +ASG D IR W +K +C+ V
Sbjct: 179 GKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL---EKFQVVSCIEGEPGPVR 235
Query: 253 DLAFSVTGTSLLSGGRESVLV 273
+ F+ G L SG ++S+ V
Sbjct: 236 SVLFNPDGCCLYSGCQDSLRV 256
Score = 32.0 bits (71), Expect = 2.4
Identities = 28/112 (25%), Positives = 38/112 (33%), Gaps = 3/112 (2%)
Query: 203 KNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTS 262
K N + HP + +ASG D I+LW + Y H V L FS G
Sbjct: 105 KANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRY---RGHSQAVRCLRFSPDGKW 161
Query: 263 LLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKI 314
L S + + W K P + + P L + SD I
Sbjct: 162 LASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTI 213
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 45.1 bits (105), Expect = 3e-04
Identities = 96/468 (20%), Positives = 172/468 (36%), Gaps = 80/468 (17%)
Query: 73 LYSCSLDGTIKLWDYIDGILI------KTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDI 126
L+ + DG ++LWD G + + I GC L PD
Sbjct: 1732 LFLTAFDGLLELWDLQHGCRVLQTKAHQYQITGCCL--------------------SPDC 1771
Query: 127 FQLVSVKLPKSSSQ-EVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYFFKK 185
L +V L + +L+F Y +S C+AF EG V A + S+ FF+
Sbjct: 1772 RLLATVCLGGCLKLWDTVRGQLAFQHTY-PKSLNCVAFHPEG-QVIATGSWAGSISFFQV 1829
Query: 186 KTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLH 245
L +++ + +A + +A G +D + LW + +
Sbjct: 1830 DG-----LKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPA-- 1882
Query: 246 WHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIE-HISVSPAGDL 304
HH V F G LL+ G + + W + + + L L + +++SP GD
Sbjct: 1883 -HHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDR 1941
Query: 305 FCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQ 364
+ + I I ++ S QG D ++ + P K LV + G LQ ++L+
Sbjct: 1942 VAVGYRADGIRI-YKISSGSQGAQGQALDVAVSALAWLSP--KVLVSGAEDGSLQGWALK 1998
Query: 365 --SDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMKLW 422
S + L+ L Q+ + LAT ++ +E + ++LW
Sbjct: 1999 ECSLQSLWLLSRFQKPVLG--------------------LATSQELLASASE-DFTVQLW 2037
Query: 423 MYN-----KKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTD 477
K + F T++ HE ++ F ++ +L T +D W
Sbjct: 2038 PRQLLTRPHKAEDFPCGTELR-GHEGPVSCCSF----STDGGSLATGGRDRSLLCW---- 2088
Query: 478 DSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWD 525
D+ + H+ T C +++D L++ S + V +WD
Sbjct: 2089 --DVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWD 2134
Score = 37.0 bits (84), Expect = 0.075
Identities = 47/223 (21%), Positives = 83/223 (37%), Gaps = 18/223 (8%)
Query: 56 HRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDSV 115
HR+ VTG +N L SCS DG++ LWD G + F+ A+ +A E+ V
Sbjct: 2106 HRDWVTGCAWTKDN--LLISCSSDGSVGLWDPESGQRLGQFL--GHQSAVSAVAAVEEHV 2161
Query: 116 FVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVRE 175
+ ++ V+L + + ++ P+ + V V
Sbjct: 2162 VSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAME-----PRAAGQPGSELLVVTVGL 2216
Query: 176 FYLSVYFFKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYD 235
+ + TL A A T + + DG +RLW+
Sbjct: 2217 DGATRLWHPLLVCQTHTLLGHSGPVRA------AAVSETSGLMLTASEDGSVRLWQ---V 2267
Query: 236 DKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDA 278
K+ TC+ V +A++ G+ +SG + L+ W++A
Sbjct: 2268 PKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEA 2310
Score = 34.3 bits (77), Expect = 0.49
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 11/73 (15%)
Query: 460 TLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLA-VSFE 518
TL + DG ++W L + + H+YQ T CC S D LLA V
Sbjct: 1731 TLFLTAFDGLLELWDLQHGCRVLQTKA----------HQYQITGCCLSPDCRLLATVCLG 1780
Query: 519 EIVTIWDSVTWEL 531
+ +WD+V +L
Sbjct: 1781 GCLKLWDTVRGQL 1793
Score = 32.3 bits (72), Expect = 1.9
Identities = 21/94 (22%), Positives = 41/94 (43%), Gaps = 3/94 (3%)
Query: 223 MDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKN 282
+DG RLW + +T L H V A S T +L+ + + W+ E +
Sbjct: 2216 LDGATRLWHPLLVCQTHT---LLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEAD 2272
Query: 283 KEFLPRLGATIEHISVSPAGDLFCTSHSDNKIII 316
+PR A + ++ +P G + + + ++I+
Sbjct: 2273 DTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELIL 2306
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 45.1 bits (105), Expect = 3e-04
Identities = 56/262 (21%), Positives = 99/262 (37%), Gaps = 57/262 (21%)
Query: 14 GSELNFRRAVFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQ 72
G +L +S+DS + S D +K++ + +C+ L GH N V NP ++L
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL- 143
Query: 73 LYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSV 132
+ S S D ++++WD G +K TL D V + + S
Sbjct: 144 IVSGSFDESVRIWDVKTGKCLK------------TLPAHSDPVSAVHFNRDGSLIVSSSY 191
Query: 133 KLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYV-AAVREFYLSVYFFKKKTTSRF 191
+ L ++D N + F G Y+ AA + L ++ + K +
Sbjct: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK- 250
Query: 192 TLSSSRNKKH-----------------AKNNFTCV----------------------ACH 212
T + +N+K+ +++N + ACH
Sbjct: 251 TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310
Query: 213 PTEDCIASGHM--DGKIRLWRN 232
PTE+ IAS + D I+LW++
Sbjct: 311 PTENIIASAALENDKTIKLWKS 332
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/66 (36%), Positives = 34/66 (51%), Gaps = 3/66 (4%)
Query: 53 LHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQAE 112
L GH V+ ++ +PN L S S D IK+W DG KT I G KL + +A +
Sbjct: 41 LAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKT-ISGHKL-GISDVAWSS 97
Query: 113 DSVFVI 118
DS ++
Sbjct: 98 DSNLLV 103
Score = 30.0 bits (66), Expect = 9.2
Identities = 40/185 (21%), Positives = 72/185 (38%), Gaps = 32/185 (17%)
Query: 390 LTKAAFGCFGNWLATVEQRQEKETELELQMKLW-MYNKKTQGFILNTKINMPHEDCITAL 448
++ F G WLA+ + + +K+W Y+ K + I K+ +
Sbjct: 48 VSSVKFSPNGEWLAS--------SSADKLIKIWGAYDGKFEKTISGHKLGISDV------ 93
Query: 449 CFCNAEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSE 508
A S+ LV+AS D K+W ++ + K G H C F+
Sbjct: 94 ----AWSSDSNLLVSASDDKTLKIWDVSSGKCL-KTLKG---------HSNYVFCCNFNP 139
Query: 509 DGSLLAV-SFEEIVTIWDSVTWELKCTFCQRAGKIRHLCFGRLTCSKYLLGATENGILCC 567
+L+ SF+E V IWD T + T + + + F R ++ ++ +G+
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR--DGSLIVSSSYDGLCRI 197
Query: 568 WNLLS 572
W+ S
Sbjct: 198 WDTAS 202
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 45.1 bits (105), Expect = 3e-04
Identities = 56/262 (21%), Positives = 99/262 (37%), Gaps = 57/262 (21%)
Query: 14 GSELNFRRAVFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQ 72
G +L +S+DS + S D +K++ + +C+ L GH N V NP ++L
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL- 143
Query: 73 LYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVNKEKPDIFQLVSV 132
+ S S D ++++WD G +K TL D V + + S
Sbjct: 144 IVSGSFDESVRIWDVKTGKCLK------------TLPAHSDPVSAVHFNRDGSLIVSSSY 191
Query: 133 KLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYV-AAVREFYLSVYFFKKKTTSRF 191
+ L ++D N + F G Y+ AA + L ++ + K +
Sbjct: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK- 250
Query: 192 TLSSSRNKKH-----------------AKNNFTCV----------------------ACH 212
T + +N+K+ +++N + ACH
Sbjct: 251 TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310
Query: 213 PTEDCIASGHM--DGKIRLWRN 232
PTE+ IAS + D I+LW++
Sbjct: 311 PTENIIASAALENDKTIKLWKS 332
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/66 (36%), Positives = 34/66 (51%), Gaps = 3/66 (4%)
Query: 53 LHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQAE 112
L GH V+ ++ +PN L S S D IK+W DG KT I G KL + +A +
Sbjct: 41 LAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKT-ISGHKL-GISDVAWSS 97
Query: 113 DSVFVI 118
DS ++
Sbjct: 98 DSNLLV 103
Score = 30.0 bits (66), Expect = 9.2
Identities = 40/185 (21%), Positives = 72/185 (38%), Gaps = 32/185 (17%)
Query: 390 LTKAAFGCFGNWLATVEQRQEKETELELQMKLW-MYNKKTQGFILNTKINMPHEDCITAL 448
++ F G WLA+ + + +K+W Y+ K + I K+ +
Sbjct: 48 VSSVKFSPNGEWLAS--------SSADKLIKIWGAYDGKFEKTISGHKLGISDV------ 93
Query: 449 CFCNAEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSE 508
A S+ LV+AS D K+W ++ + K G H C F+
Sbjct: 94 ----AWSSDSNLLVSASDDKTLKIWDVSSGKCL-KTLKG---------HSNYVFCCNFNP 139
Query: 509 DGSLLAV-SFEEIVTIWDSVTWELKCTFCQRAGKIRHLCFGRLTCSKYLLGATENGILCC 567
+L+ SF+E V IWD T + T + + + F R ++ ++ +G+
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR--DGSLIVSSSYDGLCRI 197
Query: 568 WNLLS 572
W+ S
Sbjct: 198 WDTAS 202
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/71 (35%), Positives = 34/71 (47%), Gaps = 8/71 (11%)
Query: 33 CVSGDFVKVYSTVTEECVHILHGHRNLVTGIQL--------NPNNHLQLYSCSLDGTIKL 84
C +K++S + CVH L H + I+ NPN +L L S S D T++L
Sbjct: 367 CSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRL 426
Query: 85 WDYIDGILIKT 95
WD GI I T
Sbjct: 427 WDVDRGICIHT 437
Score = 33.1 bits (74), Expect = 1.1
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 12/54 (22%)
Query: 43 STVTEECVHI-----------LHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLW 85
S T+ C+H+ GH N V I+ +P +L L SCS D T+K+W
Sbjct: 324 SCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNL-LASCSDDMTLKIW 376
>gi|34996489 pleckstrin homology domain interacting protein [Homo
sapiens]
Length = 1821
Score = 44.3 bits (103), Expect = 5e-04
Identities = 20/70 (28%), Positives = 41/70 (58%)
Query: 27 DSKYIFCVSGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWD 86
D+ I V+ +KV+++ T + +H+L GH + V ++ +P + L+S DG + +WD
Sbjct: 436 DNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWD 495
Query: 87 YIDGILIKTF 96
G+ I+++
Sbjct: 496 LARGVKIRSY 505
>gi|55769546 PAK1 interacting protein 1 [Homo sapiens]
Length = 392
Score = 43.9 bits (102), Expect = 6e-04
Identities = 43/190 (22%), Positives = 81/190 (42%), Gaps = 22/190 (11%)
Query: 48 ECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALFT 107
EC+ + H+ VT + ++P+ L L S D T++ W+ ++G FI K +A
Sbjct: 114 ECLKSIKAHKGQVTFLSIHPSGKLAL-SVGTDKTLRTWNLVEGR--SAFIKNIKQNAHIV 170
Query: 108 LAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEG 167
+V++ + K DI+QL + + + + E + F +++S +A G+E
Sbjct: 171 EWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISSVKF----LSESVLAVA-GDEE 225
Query: 168 VYVAAVREFYLSVYFFKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKI 227
V + + + FK ++ K+ F+ P I S DG I
Sbjct: 226 VIRFFDCDSLVCLCEFKA------------HENRVKDMFSFEI--PEHHVIVSASSDGFI 271
Query: 228 RLWRNFYDDK 237
++W+ D K
Sbjct: 272 KMWKLKQDKK 281
Score = 34.3 bits (77), Expect = 0.49
Identities = 26/110 (23%), Positives = 44/110 (40%), Gaps = 4/110 (3%)
Query: 496 YHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKIRHLCFGRLTCSKY 555
+H T F + L++ + + ++ IWD+ WE + G++ L K
Sbjct: 80 HHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIH--PSGKL 137
Query: 556 LLGATENGILCCWNLLS--CALEWNAKLNVRVMEPDPNSENIAAISQSSV 603
L + L WNL+ A N K N ++E P E I Q+ +
Sbjct: 138 ALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKI 187
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/128 (26%), Positives = 51/128 (39%), Gaps = 5/128 (3%)
Query: 194 SSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMD 253
S R+ K ++ TCV +ASG MD + +W + Y +T H D V
Sbjct: 10 SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT---GHKDAVTC 66
Query: 254 LAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDN- 312
+ FS +G L SG R+ + W + AT+ + G F T+ D
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 313 -KIIIIHR 319
K+ HR
Sbjct: 127 VKVWATHR 134
Score = 41.2 bits (95), Expect = 0.004
Identities = 67/308 (21%), Positives = 127/308 (41%), Gaps = 40/308 (12%)
Query: 24 FSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTI 82
FS ++K + S D + V+ + + GH++ VT + +P+ HL L S S D T+
Sbjct: 27 FSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL-LASGSRDKTV 85
Query: 83 KLWDYIDGILIKTFIVGCKLHALFTLAQAEDSV-FVIVNKEKPDIFQLVSVKLPKSSSQE 141
++W + + ++ + + ++ D FV + +K +VK+ + Q
Sbjct: 86 RIW--VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK-------TVKVWATHRQ- 135
Query: 142 VEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYFFKKKTTSRFTLSSSRNKKH 201
K L + +IN +C F +G + + + T + SSR H
Sbjct: 136 ---KFLFSLSQHINWV-RCAKFSPDGRLIVSASD----------DKTVKLWDKSSRECVH 181
Query: 202 AKNNF----TCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHW--HHDMVMDLA 255
+ T V HP+ CIA+ MD +++W D + H+ H V L+
Sbjct: 182 SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW-----DVRTHRLLQHYQLHSAAVNGLS 236
Query: 256 FSVTGTSLLSGGRESVLVEWRDATEKNKEF-LPRLGATIEHISVSPAGDLFCTSHSDNKI 314
F +G L++ +S L + D E + L ++ S G+ F + SD ++
Sbjct: 237 FHPSGNYLITASSDSTL-KILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQV 295
Query: 315 IIIHRNLE 322
++ N +
Sbjct: 296 MVWKSNFD 303
Score = 37.4 bits (85), Expect = 0.058
Identities = 30/130 (23%), Positives = 55/130 (42%), Gaps = 20/130 (15%)
Query: 419 MKLWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDD 478
+++W+ N K + + H + ++ FC S+ + VTAS D KVW
Sbjct: 85 VRIWVPNVKGESTVFRA-----HTATVRSVHFC----SDGQSFVTASDDKTVKVWATHRQ 135
Query: 479 SDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLL-AVSFEEIVTIWDSVTWELKCTFCQ 537
++ S H FS DG L+ + S ++ V +WD + E ++C+
Sbjct: 136 KFLFSL----------SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE 185
Query: 538 RAGKIRHLCF 547
G + ++ F
Sbjct: 186 HGGFVTYVDF 195
Score = 33.5 bits (75), Expect = 0.83
Identities = 23/68 (33%), Positives = 35/68 (51%), Gaps = 2/68 (2%)
Query: 20 RRAVFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSL 78
R F +D + S D VKV++T ++ + L H N V + +P+ L + S S
Sbjct: 107 RSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL-IVSASD 165
Query: 79 DGTIKLWD 86
D T+KLWD
Sbjct: 166 DKTVKLWD 173
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/128 (26%), Positives = 51/128 (39%), Gaps = 5/128 (3%)
Query: 194 SSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMD 253
S R+ K ++ TCV +ASG MD + +W + Y +T H D V
Sbjct: 10 SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT---GHKDAVTC 66
Query: 254 LAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDN- 312
+ FS +G L SG R+ + W + AT+ + G F T+ D
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 313 -KIIIIHR 319
K+ HR
Sbjct: 127 VKVWATHR 134
Score = 41.2 bits (95), Expect = 0.004
Identities = 67/308 (21%), Positives = 127/308 (41%), Gaps = 40/308 (12%)
Query: 24 FSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTI 82
FS ++K + S D + V+ + + GH++ VT + +P+ HL L S S D T+
Sbjct: 27 FSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL-LASGSRDKTV 85
Query: 83 KLWDYIDGILIKTFIVGCKLHALFTLAQAEDSV-FVIVNKEKPDIFQLVSVKLPKSSSQE 141
++W + + ++ + + ++ D FV + +K +VK+ + Q
Sbjct: 86 RIW--VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK-------TVKVWATHRQ- 135
Query: 142 VEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSVYFFKKKTTSRFTLSSSRNKKH 201
K L + +IN +C F +G + + + T + SSR H
Sbjct: 136 ---KFLFSLSQHINWV-RCAKFSPDGRLIVSASD----------DKTVKLWDKSSRECVH 181
Query: 202 AKNNF----TCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHW--HHDMVMDLA 255
+ T V HP+ CIA+ MD +++W D + H+ H V L+
Sbjct: 182 SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW-----DVRTHRLLQHYQLHSAAVNGLS 236
Query: 256 FSVTGTSLLSGGRESVLVEWRDATEKNKEF-LPRLGATIEHISVSPAGDLFCTSHSDNKI 314
F +G L++ +S L + D E + L ++ S G+ F + SD ++
Sbjct: 237 FHPSGNYLITASSDSTL-KILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQV 295
Query: 315 IIIHRNLE 322
++ N +
Sbjct: 296 MVWKSNFD 303
Score = 37.4 bits (85), Expect = 0.058
Identities = 30/130 (23%), Positives = 55/130 (42%), Gaps = 20/130 (15%)
Query: 419 MKLWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDD 478
+++W+ N K + + H + ++ FC S+ + VTAS D KVW
Sbjct: 85 VRIWVPNVKGESTVFRA-----HTATVRSVHFC----SDGQSFVTASDDKTVKVWATHRQ 135
Query: 479 SDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLL-AVSFEEIVTIWDSVTWELKCTFCQ 537
++ S H FS DG L+ + S ++ V +WD + E ++C+
Sbjct: 136 KFLFSL----------SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE 185
Query: 538 RAGKIRHLCF 547
G + ++ F
Sbjct: 186 HGGFVTYVDF 195
Score = 33.5 bits (75), Expect = 0.83
Identities = 23/68 (33%), Positives = 35/68 (51%), Gaps = 2/68 (2%)
Query: 20 RRAVFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSL 78
R F +D + S D VKV++T ++ + L H N V + +P+ L + S S
Sbjct: 107 RSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL-IVSASD 165
Query: 79 DGTIKLWD 86
D T+KLWD
Sbjct: 166 DKTVKLWD 173
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/83 (31%), Positives = 42/83 (50%), Gaps = 2/83 (2%)
Query: 14 GSELNFRRAVFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQ 72
G L +S+DS + S D +K++ + +C+ L GH N V NP ++L
Sbjct: 81 GHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNL- 139
Query: 73 LYSCSLDGTIKLWDYIDGILIKT 95
+ S S D T+K+W+ G +KT
Sbjct: 140 IISGSFDETVKIWEVKTGKCLKT 162
Score = 42.4 bits (98), Expect = 0.002
Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 14/83 (16%)
Query: 28 SKYIFC----------VSGDF---VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLY 74
S Y+FC +SG F VK++ T +C+ L H + V+ + N + L +
Sbjct: 125 SNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL-IV 183
Query: 75 SCSLDGTIKLWDYIDGILIKTFI 97
S S DG ++WD G +KT +
Sbjct: 184 SGSYDGLCRIWDAASGQCLKTLV 206
Score = 35.0 bits (79), Expect = 0.29
Identities = 32/136 (23%), Positives = 57/136 (41%), Gaps = 13/136 (9%)
Query: 186 KTTSRFTLSSSRNKKHAKNNFTCVAC---HPTEDCIASGHMDGKIRLWRNFYDDKKYTYT 242
KT + + S + K K + V C +P + I SG D +++W + T
Sbjct: 105 KTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW------EVKTGK 158
Query: 243 CLHW---HHDMVMDLAFSVTGTSLLSGGRESVLVEWRDAT-EKNKEFLPRLGATIEHISV 298
CL H D V + F+ +G+ ++SG + + W A+ + K + + +
Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218
Query: 299 SPAGDLFCTSHSDNKI 314
SP G T+ DN +
Sbjct: 219 SPNGKYILTATLDNTL 234
Score = 34.7 bits (78), Expect = 0.37
Identities = 21/67 (31%), Positives = 37/67 (55%), Gaps = 5/67 (7%)
Query: 34 VSGDF---VKVYSTVTEECVHILHGHRNL-VTGIQLNPNNHLQLYSCSLDGTIKLWDYID 89
VSG + +++ + +C+ L N V+ ++ +PN L + +LD T+KLWDY
Sbjct: 183 VSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYIL-TATLDNTLKLWDYSR 241
Query: 90 GILIKTF 96
G +KT+
Sbjct: 242 GRCLKTY 248
Score = 30.4 bits (67), Expect = 7.0
Identities = 22/60 (36%), Positives = 33/60 (55%), Gaps = 4/60 (6%)
Query: 29 KYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSL--DGTIKLW 85
K+I S D V +++ T+E V L GH ++V +P +L + S +L D TIKLW
Sbjct: 268 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENL-IASAALENDKTIKLW 326
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 42.7 bits (99), Expect = 0.001
Identities = 28/73 (38%), Positives = 38/73 (52%), Gaps = 4/73 (5%)
Query: 23 VFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGT 81
V D KYI SGD +KV+ST T E V L+GH+ + +Q + S S D T
Sbjct: 368 VVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR---LVVSGSSDNT 424
Query: 82 IKLWDYIDGILIK 94
I+LWD G ++
Sbjct: 425 IRLWDIECGACLR 437
Score = 37.7 bits (86), Expect = 0.044
Identities = 26/98 (26%), Positives = 45/98 (45%), Gaps = 15/98 (15%)
Query: 11 RCGGSELNFRRAVFSADSKYIFCVSGD-----------FVKVYSTVTEECVHILHGHRNL 59
RCG L R S +SK ++C+ D +K++ + EC+ +L GH
Sbjct: 224 RCGRHNLQ-RIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGS 282
Query: 60 VTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFI 97
V +Q + + + S D T+++WD G ++ T I
Sbjct: 283 VLCLQYDER---VIVTGSSDSTVRVWDVNTGEVLNTLI 317
Score = 34.3 bits (77), Expect = 0.49
Identities = 42/171 (24%), Positives = 72/171 (42%), Gaps = 21/171 (12%)
Query: 361 YSLQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLAT-VEQRQEKETELELQM 419
Y LQ D + + ++ I + +E K G G+ L ++R + +
Sbjct: 244 YCLQYDDEKI-ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTV 302
Query: 420 KLWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDDS 479
++W N G +LNT I+ H + + L F N +VT SKD VW + +
Sbjct: 303 RVWDVNT---GEVLNTLIH--HNEAVLHLRFSNG------LMVTCSKDRSIAVWDMASAT 351
Query: 480 DIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWE 530
DI + V VG H+ A N +D +++ S + + +W + T E
Sbjct: 352 DITLRRV-----LVG--HR-AAVNVVDFDDKYIVSASGDRTIKVWSTSTCE 394
Score = 31.6 bits (70), Expect = 3.2
Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 3/52 (5%)
Query: 35 SGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWD 86
S + ++++ C+ +L GH LV I+ + + ++ S + DG IK+WD
Sbjct: 421 SDNTIRLWDIECGACLRVLEGHEELVRCIRFD---NKRIVSGAYDGKIKVWD 469
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 42.7 bits (99), Expect = 0.001
Identities = 22/71 (30%), Positives = 34/71 (47%), Gaps = 8/71 (11%)
Query: 33 CVSGDFVKVYSTVTEECVHILHGHRNLVTGIQL--------NPNNHLQLYSCSLDGTIKL 84
C +K++S E C+H L H + I+ NPN+++ L S S D T++L
Sbjct: 379 CSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRL 438
Query: 85 WDYIDGILIKT 95
WD G+ T
Sbjct: 439 WDIERGVCTHT 449
Score = 32.3 bits (72), Expect = 1.9
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 12/54 (22%)
Query: 43 STVTEECVHI-----------LHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLW 85
S T+ C+H+ GH N V I+ +P+ L L SCS D T+K+W
Sbjct: 336 SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIW 388
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 42.7 bits (99), Expect = 0.001
Identities = 22/71 (30%), Positives = 34/71 (47%), Gaps = 8/71 (11%)
Query: 33 CVSGDFVKVYSTVTEECVHILHGHRNLVTGIQL--------NPNNHLQLYSCSLDGTIKL 84
C +K++S E C+H L H + I+ NPN+++ L S S D T++L
Sbjct: 379 CSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRL 438
Query: 85 WDYIDGILIKT 95
WD G+ T
Sbjct: 439 WDIERGVCTHT 449
Score = 32.3 bits (72), Expect = 1.9
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 12/54 (22%)
Query: 43 STVTEECVHI-----------LHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLW 85
S T+ C+H+ GH N V I+ +P+ L L SCS D T+K+W
Sbjct: 336 SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIW 388
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 42.7 bits (99), Expect = 0.001
Identities = 22/71 (30%), Positives = 34/71 (47%), Gaps = 8/71 (11%)
Query: 33 CVSGDFVKVYSTVTEECVHILHGHRNLVTGIQL--------NPNNHLQLYSCSLDGTIKL 84
C +K++S E C+H L H + I+ NPN+++ L S S D T++L
Sbjct: 430 CSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRL 489
Query: 85 WDYIDGILIKT 95
WD G+ T
Sbjct: 490 WDIERGVCTHT 500
Score = 32.3 bits (72), Expect = 1.9
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 12/54 (22%)
Query: 43 STVTEECVHI-----------LHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLW 85
S T+ C+H+ GH N V I+ +P+ L L SCS D T+K+W
Sbjct: 387 SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIW 439
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 42.7 bits (99), Expect = 0.001
Identities = 22/71 (30%), Positives = 34/71 (47%), Gaps = 8/71 (11%)
Query: 33 CVSGDFVKVYSTVTEECVHILHGHRNLVTGIQL--------NPNNHLQLYSCSLDGTIKL 84
C +K++S E C+H L H + I+ NPN+++ L S S D T++L
Sbjct: 430 CSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRL 489
Query: 85 WDYIDGILIKT 95
WD G+ T
Sbjct: 490 WDIERGVCTHT 500
Score = 32.3 bits (72), Expect = 1.9
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 12/54 (22%)
Query: 43 STVTEECVHI-----------LHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLW 85
S T+ C+H+ GH N V I+ +P+ L L SCS D T+K+W
Sbjct: 387 SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIW 439
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 42.7 bits (99), Expect = 0.001
Identities = 28/73 (38%), Positives = 38/73 (52%), Gaps = 4/73 (5%)
Query: 23 VFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGT 81
V D KYI SGD +KV+ST T E V L+GH+ + +Q + S S D T
Sbjct: 334 VVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR---LVVSGSSDNT 390
Query: 82 IKLWDYIDGILIK 94
I+LWD G ++
Sbjct: 391 IRLWDIECGACLR 403
Score = 37.7 bits (86), Expect = 0.044
Identities = 26/98 (26%), Positives = 45/98 (45%), Gaps = 15/98 (15%)
Query: 11 RCGGSELNFRRAVFSADSKYIFCVSGD-----------FVKVYSTVTEECVHILHGHRNL 59
RCG L R S +SK ++C+ D +K++ + EC+ +L GH
Sbjct: 190 RCGRHNLQ-RIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGS 248
Query: 60 VTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFI 97
V +Q + + + S D T+++WD G ++ T I
Sbjct: 249 VLCLQYDER---VIVTGSSDSTVRVWDVNTGEVLNTLI 283
Score = 34.3 bits (77), Expect = 0.49
Identities = 42/171 (24%), Positives = 72/171 (42%), Gaps = 21/171 (12%)
Query: 361 YSLQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLAT-VEQRQEKETELELQM 419
Y LQ D + + ++ I + +E K G G+ L ++R + +
Sbjct: 210 YCLQYDDEKI-ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTV 268
Query: 420 KLWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDDS 479
++W N G +LNT I+ H + + L F N +VT SKD VW + +
Sbjct: 269 RVWDVNT---GEVLNTLIH--HNEAVLHLRFSNG------LMVTCSKDRSIAVWDMASAT 317
Query: 480 DIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWE 530
DI + V VG H+ A N +D +++ S + + +W + T E
Sbjct: 318 DITLRRV-----LVG--HR-AAVNVVDFDDKYIVSASGDRTIKVWSTSTCE 360
Score = 31.6 bits (70), Expect = 3.2
Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 3/52 (5%)
Query: 35 SGDFVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWD 86
S + ++++ C+ +L GH LV I+ + + ++ S + DG IK+WD
Sbjct: 387 SDNTIRLWDIECGACLRVLEGHEELVRCIRFD---NKRIVSGAYDGKIKVWD 435
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,747,615
Number of Sequences: 37866
Number of extensions: 1437190
Number of successful extensions: 8896
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 114
Number of HSP's successfully gapped in prelim test: 194
Number of HSP's that attempted gapping in prelim test: 7311
Number of HSP's gapped (non-prelim): 1394
length of query: 830
length of database: 18,247,518
effective HSP length: 111
effective length of query: 719
effective length of database: 14,044,392
effective search space: 10097917848
effective search space used: 10097917848
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.