Guide to the Human Genome
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Search of human proteins with 28558982

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|28558982 thyroid peroxidase isoform a [Homo sapiens]
         (933 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|28558982 thyroid peroxidase isoform a [Homo sapiens]              1933   0.0  
gi|28558988 thyroid peroxidase isoform d [Homo sapiens]              1811   0.0  
gi|28558984 thyroid peroxidase isoform b [Homo sapiens]              1793   0.0  
gi|28558990 thyroid peroxidase isoform e [Homo sapiens]              1025   0.0  
gi|4557759 myeloperoxidase [Homo sapiens]                             606   e-173
gi|4503595 eosinophil peroxidase [Homo sapiens]                       596   e-170
gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens]    540   e-153
gi|109150416 peroxidasin [Homo sapiens]                               539   e-153
gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens]   533   e-151
gi|126517478 peroxidasin homolog-like [Homo sapiens]                  474   e-133
gi|20149640 dual oxidase 1 precursor [Homo sapiens]                   130   4e-30
gi|28872751 dual oxidase 1 precursor [Homo sapiens]                   130   4e-30
gi|132566532 dual oxidase 2 precursor [Homo sapiens]                  120   8e-27
gi|148886654 polydom [Homo sapiens]                                    72   2e-12
gi|194328809 latent transforming growth factor beta binding prot...    64   5e-10
gi|18497288 latent transforming growth factor beta binding prote...    64   5e-10
gi|4506265 prostaglandin-endoperoxide synthase 2 precursor [Homo...    57   1e-07
gi|24430141 fibrillin 1 precursor [Homo sapiens]                       55   4e-07
gi|66346695 fibrillin 2 precursor [Homo sapiens]                       52   2e-06
gi|56237021 fibrillin 3 precursor [Homo sapiens]                       52   2e-06
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]                52   2e-06
gi|157384998 low density lipoprotein receptor-related protein 4 ...    51   4e-06
gi|122937283 6720455I24Rik homolog [Homo sapiens]                      51   4e-06
gi|110347437 latent transforming growth factor beta binding prot...    51   6e-06
gi|110347412 latent transforming growth factor beta binding prot...    51   6e-06
gi|110347431 latent transforming growth factor beta binding prot...    51   6e-06
gi|46249414 latent transforming growth factor beta binding prote...    50   7e-06
gi|46249412 latent transforming growth factor beta binding prote...    50   7e-06
gi|18104969 prostaglandin-endoperoxide synthase 1 isoform 2 prec...    50   1e-05
gi|18104967 prostaglandin-endoperoxide synthase 1 isoform 1 prec...    50   1e-05

>gi|28558982 thyroid peroxidase isoform a [Homo sapiens]
          Length = 933

 Score = 1933 bits (5008), Expect = 0.0
 Identities = 933/933 (100%), Positives = 933/933 (100%)

Query: 1   MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR 60
           MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
Sbjct: 1   MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR 60

Query: 61  NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS 120
           NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
Sbjct: 61  NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS 120

Query: 121 EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV 180
           EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
Sbjct: 121 EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV 180

Query: 181 YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD 240
           YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
Sbjct: 181 YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD 240

Query: 241 IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD 300
           IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD
Sbjct: 241 IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD 300

Query: 301 QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG 360
           QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG
Sbjct: 301 QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG 360

Query: 361 RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA 420
           RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA
Sbjct: 361 RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA 420

Query: 421 LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT 480
           LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT
Sbjct: 421 LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT 480

Query: 481 VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR 540
           VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR
Sbjct: 481 VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR 540

Query: 541 GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL 600
           GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL
Sbjct: 541 GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL 600

Query: 601 PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ 660
           PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ
Sbjct: 601 PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ 660

Query: 661 MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES 720
           MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES
Sbjct: 661 MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES 720

Query: 721 CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL 780
           CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL
Sbjct: 721 CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL 780

Query: 781 TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD
Sbjct: 781 TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840

Query: 841 SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ 900
           SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ
Sbjct: 841 SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ 900

Query: 901 AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL 933
           AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL
Sbjct: 901 AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL 933


>gi|28558988 thyroid peroxidase isoform d [Homo sapiens]
          Length = 889

 Score = 1811 bits (4692), Expect = 0.0
 Identities = 889/933 (95%), Positives = 889/933 (95%), Gaps = 44/933 (4%)

Query: 1   MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR 60
           MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
Sbjct: 1   MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR 60

Query: 61  NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS 120
           NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
Sbjct: 61  NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS 120

Query: 121 EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV 180
           EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
Sbjct: 121 EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV 180

Query: 181 YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD 240
           YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
Sbjct: 181 YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD 240

Query: 241 IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD 300
           IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD
Sbjct: 241 IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD 300

Query: 301 QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG 360
           QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG
Sbjct: 301 QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG 360

Query: 361 RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA 420
           RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA
Sbjct: 361 RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA 420

Query: 421 LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT 480
           LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT
Sbjct: 421 LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT 480

Query: 481 VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR 540
           VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR
Sbjct: 481 VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR 540

Query: 541 GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL 600
           GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL
Sbjct: 541 GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL 600

Query: 601 PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ 660
           PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ
Sbjct: 601 PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ 660

Query: 661 MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES 720
           MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES
Sbjct: 661 MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES 720

Query: 721 CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL 780
           CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL
Sbjct: 721 CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL 780

Query: 781 TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           TCTQEGWDFQPPLCK                                            D
Sbjct: 781 TCTQEGWDFQPPLCK--------------------------------------------D 796

Query: 841 SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ 900
           SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ
Sbjct: 797 SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ 856

Query: 901 AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL 933
           AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL
Sbjct: 857 AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL 889


>gi|28558984 thyroid peroxidase isoform b [Homo sapiens]
          Length = 876

 Score = 1793 bits (4644), Expect = 0.0
 Identities = 875/933 (93%), Positives = 876/933 (93%), Gaps = 57/933 (6%)

Query: 1   MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR 60
           MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
Sbjct: 1   MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR 60

Query: 61  NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS 120
           NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
Sbjct: 61  NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS 120

Query: 121 EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV 180
           EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
Sbjct: 121 EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV 180

Query: 181 YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD 240
           YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
Sbjct: 181 YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD 240

Query: 241 IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD 300
           IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD
Sbjct: 241 IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD 300

Query: 301 QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG 360
           QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG
Sbjct: 301 QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG 360

Query: 361 RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA 420
           RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA
Sbjct: 361 RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA 420

Query: 421 LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT 480
           LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT
Sbjct: 421 LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT 480

Query: 481 VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR 540
           VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWT         L+R
Sbjct: 481 VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWT---------LLR 531

Query: 541 GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL 600
           G                                                GYNEWREFCGL
Sbjct: 532 G------------------------------------------------GYNEWREFCGL 543

Query: 601 PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ 660
           PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ
Sbjct: 544 PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ 603

Query: 661 MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES 720
           MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES
Sbjct: 604 MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES 663

Query: 721 CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL 780
           CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL
Sbjct: 664 CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL 723

Query: 781 TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD
Sbjct: 724 TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 783

Query: 841 SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ 900
           SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ
Sbjct: 784 SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ 843

Query: 901 AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL 933
           AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL
Sbjct: 844 AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL 876


>gi|28558990 thyroid peroxidase isoform e [Homo sapiens]
          Length = 760

 Score = 1025 bits (2651), Expect = 0.0
 Identities = 488/488 (100%), Positives = 488/488 (100%)

Query: 446 QIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLD 505
           QIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLD
Sbjct: 273 QIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLD 332

Query: 506 ASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLF 565
           ASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLF
Sbjct: 333 ASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLF 392

Query: 566 VLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDL 625
           VLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDL
Sbjct: 393 VLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDL 452

Query: 626 YKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRE 685
           YKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRE
Sbjct: 453 YKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRE 512

Query: 686 LEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFP 745
           LEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFP
Sbjct: 513 LEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFP 572

Query: 746 ESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAH 805
           ESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAH
Sbjct: 573 ESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAH 632

Query: 806 PPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRVTWISMSLAALLIGGFAGL 865
           PPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRVTWISMSLAALLIGGFAGL
Sbjct: 633 PPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRVTWISMSLAALLIGGFAGL 692

Query: 866 TSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQAVGTSPQRAAAQDSEQESAGMEGRD 925
           TSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQAVGTSPQRAAAQDSEQESAGMEGRD
Sbjct: 693 TSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQAVGTSPQRAAAQDSEQESAGMEGRD 752

Query: 926 THRLPRAL 933
           THRLPRAL
Sbjct: 753 THRLPRAL 760



 Score =  564 bits (1453), Expect = e-160
 Identities = 273/274 (99%), Positives = 274/274 (100%)

Query: 1   MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR 60
           MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
Sbjct: 1   MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR 60

Query: 61  NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS 120
           NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
Sbjct: 61  NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS 120

Query: 121 EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV 180
           EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
Sbjct: 121 EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV 180

Query: 181 YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD 240
           YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
Sbjct: 181 YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD 240

Query: 241 IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQL 274
           IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQ+
Sbjct: 241 IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQI 274


>gi|4557759 myeloperoxidase [Homo sapiens]
          Length = 745

 Score =  606 bits (1562), Expect = e-173
 Identities = 313/708 (44%), Positives = 437/708 (61%), Gaps = 24/708 (3%)

Query: 32  GKPEESRVSSVLEESKRLVDTAMYATMQRNLKKR---GILSPAQLLSFSKLPEPTSGVIA 88
           G+ + S V S +EE+K+LVD A Y   + ++K+R   G  SP +LLS+ K P   +    
Sbjct: 55  GEVDTSLVLSSMEEAKQLVDKA-YKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAV 113

Query: 89  RAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLA 148
           RAA+ +  ++  ++RK+    ++  + TD L+   L++++  SGC    +   CP     
Sbjct: 114 RAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQ--- 170

Query: 149 NKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREV 208
           +KYR ITG CNNR  P  GASN A  RWLP  YEDGFS P GW PG   NGFP+   R V
Sbjct: 171 DKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAV 230

Query: 209 TRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNP 268
           +  +++   + +T D   S + M WGQ +DHD+ FTP+  ++A+F  G +C+ +C  Q P
Sbjct: 231 SNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPP 290

Query: 269 CFPIQLP-EEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDAS 327
           CFP+++P  + R      C+PF+RS  AC            S    R Q+N LTSF+DAS
Sbjct: 291 CFPLKIPPNDPRIKNQADCIPFFRSCPACPG----------SNITIRNQINALTSFVDAS 340

Query: 328 TVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRG 387
            VYGS   L R LRN ++  GLL V+ R +D+GRA LPF                   R 
Sbjct: 341 MVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRS----ARI 396

Query: 388 PCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQI 447
           PCFLAGD R+SE+P LT++HTL LREHNRLA  LK+LN  W  + +YQEARK+VGA+ QI
Sbjct: 397 PCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQI 456

Query: 448 ITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS 507
           IT RDY+P +LGP A ++Y+  Y  Y+ + +P ++NVF T AFR+GH  I P + RLD  
Sbjct: 457 ITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDNR 515

Query: 508 FQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVL 567
           +Q     P + L + FF+ W ++  GG+DP++RGL+A PAKL  Q+Q+  +E+ ERLF  
Sbjct: 516 YQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQ 575

Query: 568 SNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYK 627
                LDL ++N+QR RDHGLPGYN WR FCGLP+ ET   L T + +  +A K+++ Y 
Sbjct: 576 VMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYG 635

Query: 628 HPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELE 687
            P+NID+W+GG++E    + R GPL AC+IG Q + LRDGD FWWEN  VF+  QR+ L 
Sbjct: 636 TPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALA 695

Query: 688 KHSLSRVICDNTGLTRVPM-DAFQVGKFPEDFESCDSITGMNLEAWRE 734
           + SL R+ICDNTG+T V   + F    +P DF +C ++  +NL +WRE
Sbjct: 696 QISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWRE 743


>gi|4503595 eosinophil peroxidase [Homo sapiens]
          Length = 715

 Score =  596 bits (1537), Expect = e-170
 Identities = 314/708 (44%), Positives = 428/708 (60%), Gaps = 25/708 (3%)

Query: 32  GKPEESRVSSVLEESKRLVDTAMYATMQRNLKKR---GILSPAQLLSFSKLPEPTSGVIA 88
           G  E S +   + E+K LVD A Y   Q+++K+R   G  SP  LLS+ K P   +  + 
Sbjct: 29  GAVETSVLRDCIAEAKLLVDAA-YNWTQKSIKQRLRSGSASPMDLLSYFKQPVAATRTVV 87

Query: 89  RAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLA 148
           RAA+ M  ++  ++ K+  +     + TD L+E  L +++  SGC       +C     +
Sbjct: 88  RAADYMHVALGLLEEKLQPQRSGPFNVTDVLTEPQLRLLSQASGCALRDQAERC-----S 142

Query: 149 NKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREV 208
           +KYR ITG CNN+  P  GASN ALARWLP  YEDG S P GW P    NGF LP VR V
Sbjct: 143 DKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAV 202

Query: 209 TRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNP 268
           +  +++  NE +T D   + + M WGQ+IDHD+ F+P+S ++ AF  G DC+ TC    P
Sbjct: 203 SNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVDCERTCAQLPP 262

Query: 269 CFPIQLP-EEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDAS 327
           CFPI++P  + R      C+PF+RS+ +C                 R Q+N LTSF+DAS
Sbjct: 263 CFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRV----------RNQINALTSFVDAS 312

Query: 328 TVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRG 387
            VYGS  +L  +LRN T+  GLL ++ R +D+GRA LPF                   R 
Sbjct: 313 MVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLPFDNLHDDPCLLTNRS----ARI 368

Query: 388 PCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQI 447
           PCFLAGD R++E P L A+HTL++REHNRLA  L+ LN  W+ D +Y EARK++GA+ QI
Sbjct: 369 PCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQI 428

Query: 448 ITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS 507
           IT RD++P +LG    ++ +G Y GY S  +P V+NVF T AFRFGH  + P + RLD+ 
Sbjct: 429 ITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRVANVF-TLAFRFGHTMLQPFMFRLDSQ 487

Query: 508 FQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVL 567
           ++       + L  AFF+ W ++  GG+DP++RGL+A PAKL  QD ++ +EL +RLF  
Sbjct: 488 YRASAPNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQ 547

Query: 568 SNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYK 627
                LDLA++N+QR RDHGLPGYN WR FCGL +    A LS  + ++ +A K L+LY 
Sbjct: 548 VRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYG 607

Query: 628 HPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELE 687
            PDNID+W+G +AE  LP AR GPL ACL   Q +  RDGD FWW+   VFT  QR+ L 
Sbjct: 608 TPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKRGVFTKRQRKALS 667

Query: 688 KHSLSRVICDNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRET 735
           + SLSR+ICDNTG+T V  D F+   +P  F +C  I  +NL AWR T
Sbjct: 668 RISLSRIICDNTGITTVSRDIFRANIYPRGFVNCSRIPRLNLSAWRGT 715


>gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens]
          Length = 712

 Score =  540 bits (1390), Expect = e-153
 Identities = 304/701 (43%), Positives = 413/701 (58%), Gaps = 30/701 (4%)

Query: 37  SRVSSVLEESKRLVDTAMYATMQRNLKKRGILSPA--QLLSFSKLPEPTSGVIARAAEIM 94
           S +S  + ++K  V+ A   +  R        +P   QL  + K  +  +    R  ++ 
Sbjct: 32  SAISDTVSQAKVQVNKAFLDSRTRLKTAMSSETPTSRQLSEYLKHAKGRTRTAIRNGQVW 91

Query: 95  ETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPI 154
           E S++ +++K +L      + TD  S DL S+   + GC       +C + C  + YR I
Sbjct: 92  EESLKRLRQKASLT-----NVTDP-SLDLTSLSLEV-GCGAPAPVVRC-DPC--SPYRTI 141

Query: 155 TGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQ 214
           TG CNNR  P  GA+N ALARWLP  YEDG S P GW PG   NGFPLP  REV+  ++ 
Sbjct: 142 TGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGWTPGKTRNGFPLPLAREVSNKIVG 201

Query: 215 VSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQL 274
             NE    D   S L M WGQ +DHD+ F P +   ++    A C   C   + CFPI  
Sbjct: 202 YLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEYSKAQCDEYCIQGDNCFPIMF 261

Query: 275 PEEARPAAGTA--CLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGS 332
           P    P AGT   C+PF+R+   C T    +L         R+Q+N LTSFLDAS VY S
Sbjct: 262 PPND-PKAGTQGKCMPFFRAGFVCPTPPYKSL--------AREQINALTSFLDASFVYSS 312

Query: 333 SPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLA 392
            P+L  +LRN +S  GL+ V+  + D G  YLP+   + P+ C     I    R PCFLA
Sbjct: 313 EPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPY-DSKKPSPCE---FINTTARVPCFLA 368

Query: 393 GDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRD 452
           GD RASE   L   HTL+LREHNRLA  LK LN  W  + +YQEARK++GA  QIIT RD
Sbjct: 369 GDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFRD 428

Query: 453 YIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQEHP 512
           Y+P +LG +  Q+++ PY+GY  + +P +SNVF T AFRFGH  +   + RLD ++Q   
Sbjct: 429 YLPILLG-DHMQKWIPPYQGYSESVDPRISNVF-TFAFRFGHLEVPSSMFRLDENYQPWG 486

Query: 513 DLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSNS-S 571
             P L LH  FF+ W +++ GG+DPL+RGLLA+ +KL  Q+++M  EL  +LF  ++   
Sbjct: 487 PEPELPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTHRIH 546

Query: 572 TLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPDN 631
             DLA+IN QR RDHG PGYN WR FC L + +T  +L+T + S+ +A K+L LY  PDN
Sbjct: 547 GFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTPDN 606

Query: 632 IDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSL 691
           ID+W+G +AE  + R R GPL ACL+GKQ + +RDGD FWWEN  VFT+ Q+  L+K S 
Sbjct: 607 IDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGVFTNEQKDSLQKMSF 666

Query: 692 SRVICDNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAW 732
           SR++CDNT +T+VP D F    +P DF  C +I  ++L  W
Sbjct: 667 SRLVCDNTRITKVPRDPFWANSYPYDFVDCSAIDKLDLSPW 707


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score =  539 bits (1388), Expect = e-153
 Identities = 298/706 (42%), Positives = 420/706 (59%), Gaps = 25/706 (3%)

Query: 39   VSSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLP-EPTSGVIARAAEIMETS 97
            V++ + E+   VD A+ +T       R   SP  LL+  + P +P +   ARA EI E +
Sbjct: 624  VATSIVEAIATVDRAINSTRTHLFDSRP-RSPNDLLALFRYPRDPYTVEQARAGEIFERT 682

Query: 98   IQAMKRKVNLKTQ-----QSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYR 152
            +Q ++  V           S H  D +S   L++IAN+SGC  +     C + C   KYR
Sbjct: 683  LQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYR 742

Query: 153  PITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHV 212
               G CNN  HP WGAS TA  R L  VYE+GF+ PRG NP  LYNG  LP  R V+  +
Sbjct: 743  THDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTL 802

Query: 213  IQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPI 272
            I    E VT D++++ +LM WGQ++DHD+  T  + S+A F  G  C   C N  PCF +
Sbjct: 803  I--GTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPPCFSV 860

Query: 273  QLP-EEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYG 331
             +P  ++R  +G  C+ F RSS  CG+G    L   +++  PR+Q+N LTS++DAS VYG
Sbjct: 861  MIPPNDSRARSGARCMFFVRSSPVCGSGMTSLL---MNSVYPREQINQLTSYIDASNVYG 917

Query: 332  SSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFL 391
            S+    R +R+  S  GLLR    ++ SG+  LPF     P  C  +     E+  PCFL
Sbjct: 918  STEHEARSIRDLASHRGLLR-QGIVQRSGKPLLPFATG-PPTECMRDEN---ESPIPCFL 972

Query: 392  AGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLR 451
            AGD RA+E   LT++HTLW REHNR+A  L  LN HW  D +Y E RK+VGA  Q IT +
Sbjct: 973  AGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQ 1032

Query: 452  DYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQE- 510
             ++P+ILG E   + +G Y GYD   N  + N F+TAAFRFGH  ++PL+ RLD +FQ  
Sbjct: 1033 HWLPKILG-EVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPI 1091

Query: 511  -HPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSN 569
                LP   LH+AFFSP+ ++  GG+DPL+RGL     K++V  QL+N ELTERLF +++
Sbjct: 1092 AQDHLP---LHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAH 1148

Query: 570  SSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHP 629
            +  LDLA+IN+QRGRDHG+P Y+++R +C L    T  DL   I +  + +K+  LY   
Sbjct: 1149 TVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGST 1208

Query: 630  DNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKH 689
             NID++   + E+ +P +R GP   CL+  Q K LRDGD  W+EN  VF+ AQ  ++++ 
Sbjct: 1209 LNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLTQIKQT 1268

Query: 690  SLSRVICDNT-GLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRE 734
            SL+R++CDN   +TRV  D F+V +FP  + SCD I  ++L  W++
Sbjct: 1269 SLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQD 1314


>gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens]
          Length = 629

 Score =  533 bits (1373), Expect = e-151
 Identities = 279/585 (47%), Positives = 364/585 (62%), Gaps = 18/585 (3%)

Query: 151 YRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTR 210
           YR ITG CNNR  P  GA+N ALARWLP  YEDG S P GW PG   NGFPLP  REV+ 
Sbjct: 55  YRTITGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGWTPGKTRNGFPLPLAREVSN 114

Query: 211 HVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCF 270
            ++   NE    D   S L M WGQ +DHD+ F P +   ++    A C   C   + CF
Sbjct: 115 KIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEYSKAQCDEYCIQGDNCF 174

Query: 271 PIQLPEEARPAAGTA--CLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDAST 328
           PI  P    P AGT   C+PF+R+   C T    +L         R+Q+N LTSFLDAS 
Sbjct: 175 PIMFPPND-PKAGTQGKCMPFFRAGFVCPTPPYKSL--------AREQINALTSFLDASF 225

Query: 329 VYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGP 388
           VY S P+L  +LRN +S  GL+ V+  + D G  YLP+   + P+ C     I    R P
Sbjct: 226 VYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPY-DSKKPSPCE---FINTTARVP 281

Query: 389 CFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQII 448
           CFLAGD RASE   L   HTL+LREHNRLA  LK LN  W  + +YQEARK++GA  QII
Sbjct: 282 CFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQII 341

Query: 449 TLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASF 508
           T RDY+P +LG +  Q+++ PY+GY  + +P +SNVF T AFRFGH  +   + RLD ++
Sbjct: 342 TFRDYLPILLG-DHMQKWIPPYQGYSESVDPRISNVF-TFAFRFGHLEVPSSMFRLDENY 399

Query: 509 QEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLS 568
           Q     P L LH  FF+ W +++ GG+DPL+RGLLA+ +KL  Q+++M  EL  +LF  +
Sbjct: 400 QPWGPEPELPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPT 459

Query: 569 NS-STLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYK 627
           +     DLA+IN QR RDHG PGYN WR FC L + +T  +L+T + S+ +A K+L LY 
Sbjct: 460 HRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYG 519

Query: 628 HPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELE 687
            PDNID+W+G +AE  + R R GPL ACL+GKQ + +RDGD FWWEN  VFT+ Q+  L+
Sbjct: 520 TPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGVFTNEQKDSLQ 579

Query: 688 KHSLSRVICDNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAW 732
           K S SR++CDNT +T+VP D F    +P DF  C +I  ++L  W
Sbjct: 580 KMSFSRLVCDNTRITKVPRDPFWANSYPYDFVDCSAIDKLDLSPW 624


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score =  474 bits (1220), Expect = e-133
 Identities = 273/702 (38%), Positives = 390/702 (55%), Gaps = 23/702 (3%)

Query: 40   SSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQ 99
            SS+L+  +R VD+A+ +T +    ++   S   L  F    +P    +ARA EI E ++Q
Sbjct: 612  SSILDAVQR-VDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQ 670

Query: 100  AMKRKV------NLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRP 153
             ++ +V      +L+ ++ ++  D +S   LS+IAN+SGC      P C N C   KYR 
Sbjct: 671  LIRERVKQGLTVDLEGKEFRY-NDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRA 729

Query: 154  ITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVI 213
              G CNN   P WGA+ TA AR L P Y DG   PRG     + +  PLPP R V    +
Sbjct: 730  HDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLP-VGSRQPLPPPRLVA--TV 786

Query: 214  QVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQ 273
                  VT D  Y+ +LM WG +++HD+  T  + S A F  G  C   C N  PCFP+ 
Sbjct: 787  WARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMN 846

Query: 274  LPEEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSS 333
                        C+ F RSS AC +G   A    + +   R+Q+N  T+++D S VYGSS
Sbjct: 847  TRHADPRGTHAPCMLFARSSPACASGRPSA---TVDSVYAREQINQQTAYIDGSNVYGSS 903

Query: 334  PALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAG 393
                + LR+ +   GLL+       SG+  LPF     P  CA +     E   PCFLAG
Sbjct: 904  ERESQALRDPSVPRGLLKTGFPWPPSGKPLLPF-STGPPTECARQ-----EQESPCFLAG 957

Query: 394  DGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDY 453
            D RA+E  +L A+HTLW REHNR+A  L ALN HW  + VYQEARK+VGA  Q IT   +
Sbjct: 958  DHRANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHW 1017

Query: 454  IPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQEHPD 513
            +P++LG    +   G Y GY+   N  + N F+TAAFRFGH  I+P++ RL+A+  E  +
Sbjct: 1018 LPKVLGDPGTRMLRG-YRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISE 1076

Query: 514  LPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSNSSTL 573
               L  H+A FSP  +++ GG+DP++RGL    AK +    L++ ELT+RLF  + S+ +
Sbjct: 1077 -GHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAV 1135

Query: 574  DLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPDNID 633
            D A+  +QRGRDHG+P Y ++R FC L  ++   DL   I    +  K+  LY  P +ID
Sbjct: 1136 DSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDID 1195

Query: 634  VWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSLSR 693
            +W   + E+ +P  R GP   CL   Q + LRDGD FW+EN  VFT AQ  +L++ SLSR
Sbjct: 1196 LWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSR 1255

Query: 694  VICDN-TGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRE 734
            V+CDN   + +V  D F   ++P+D+ +C  I  ++L  W++
Sbjct: 1256 VLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQD 1297


>gi|20149640 dual oxidase 1 precursor [Homo sapiens]
          Length = 1551

 Score =  130 bits (328), Expect = 4e-30
 Identities = 155/561 (27%), Positives = 241/561 (42%), Gaps = 74/561 (13%)

Query: 156 GACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGW----NPGFLYNGFPLPPVREVTRH 211
           G  NN    RWG+  + L R +P  Y DG  QP G     NP  L N     P       
Sbjct: 34  GWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLSNTISRGPAG----- 88

Query: 212 VIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFP 271
           +  + N  V        L + +G ++  D+         A F       +     +P F 
Sbjct: 89  LASLRNRTV--------LGVFFGYHVLSDLVSVETPGCPAEF-----LNIRIPPGDPMFD 135

Query: 272 IQLPEEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYG 331
              P++     G   LPF RS     TG         S +NPR   N +T +LD S +YG
Sbjct: 136 ---PDQR----GDVVLPFQRSRWDPETGR--------SPSNPRDPANQVTGWLDGSAIYG 180

Query: 332 SSPALERQLRNWTSAEGLLRVHARL-RDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCF 390
           SS +    LR+++  +          RDS    L +         AP+P          +
Sbjct: 181 SSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWA--------APDPATGQNGPRGLY 232

Query: 391 LAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITL 450
             G  R +  P L AL  LW R HN  A  L   +  W  + ++Q ARK V A +Q I +
Sbjct: 233 AFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAV 292

Query: 451 RDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS--F 508
            +++P  L     Q+ +  Y GY    +P++S+ F  A+ +F    + P V   +AS  F
Sbjct: 293 YEWLPSFL-----QKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHF 347

Query: 509 Q-----EHPDLPGLWLHQAFFSPW--TLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELT 561
           Q            L +  +++S    +L     +D L+ G+ ++ A  + +D ++ E++ 
Sbjct: 348 QGVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIA--EREDHVLVEDVR 405

Query: 562 ERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADK 621
           +        S  D  +  LQRGRD GLP Y + R   GL  +    D++ A+ SRS  D 
Sbjct: 406 DFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPAL-SRS-NDT 463

Query: 622 ILDLYKHPDNIDV-WL----GGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSH 676
           +L+      N D+ WL    GGL E+       GPLF+ ++ +Q   LRDGD +W+EN+ 
Sbjct: 464 VLEATAALYNQDLSWLELLPGGLLES---HRDPGPLFSTIVLEQFVRLRDGDRYWFENTR 520

Query: 677 --VFTDAQRRELEKHSLSRVI 695
             +F+  +  E+   +L  V+
Sbjct: 521 NGLFSKKEIEEIRNTTLQDVL 541


>gi|28872751 dual oxidase 1 precursor [Homo sapiens]
          Length = 1551

 Score =  130 bits (328), Expect = 4e-30
 Identities = 155/561 (27%), Positives = 241/561 (42%), Gaps = 74/561 (13%)

Query: 156 GACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGW----NPGFLYNGFPLPPVREVTRH 211
           G  NN    RWG+  + L R +P  Y DG  QP G     NP  L N     P       
Sbjct: 34  GWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLSNTISRGPAG----- 88

Query: 212 VIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFP 271
           +  + N  V        L + +G ++  D+         A F       +     +P F 
Sbjct: 89  LASLRNRTV--------LGVFFGYHVLSDLVSVETPGCPAEF-----LNIRIPPGDPMFD 135

Query: 272 IQLPEEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYG 331
              P++     G   LPF RS     TG         S +NPR   N +T +LD S +YG
Sbjct: 136 ---PDQR----GDVVLPFQRSRWDPETGR--------SPSNPRDPANQVTGWLDGSAIYG 180

Query: 332 SSPALERQLRNWTSAEGLLRVHARL-RDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCF 390
           SS +    LR+++  +          RDS    L +         AP+P          +
Sbjct: 181 SSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWA--------APDPATGQNGPRGLY 232

Query: 391 LAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITL 450
             G  R +  P L AL  LW R HN  A  L   +  W  + ++Q ARK V A +Q I +
Sbjct: 233 AFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAV 292

Query: 451 RDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS--F 508
            +++P  L     Q+ +  Y GY    +P++S+ F  A+ +F    + P V   +AS  F
Sbjct: 293 YEWLPSFL-----QKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHF 347

Query: 509 Q-----EHPDLPGLWLHQAFFSPW--TLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELT 561
           Q            L +  +++S    +L     +D L+ G+ ++ A  + +D ++ E++ 
Sbjct: 348 QGVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIA--EREDHVLVEDVR 405

Query: 562 ERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADK 621
           +        S  D  +  LQRGRD GLP Y + R   GL  +    D++ A+ SRS  D 
Sbjct: 406 DFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPAL-SRS-NDT 463

Query: 622 ILDLYKHPDNIDV-WL----GGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSH 676
           +L+      N D+ WL    GGL E+       GPLF+ ++ +Q   LRDGD +W+EN+ 
Sbjct: 464 VLEATAALYNQDLSWLELLPGGLLES---HRDPGPLFSTIVLEQFVRLRDGDRYWFENTR 520

Query: 677 --VFTDAQRRELEKHSLSRVI 695
             +F+  +  E+   +L  V+
Sbjct: 521 NGLFSKKEIEEIRNTTLQDVL 541


>gi|132566532 dual oxidase 2 precursor [Homo sapiens]
          Length = 1548

 Score =  120 bits (300), Expect = 8e-27
 Identities = 118/430 (27%), Positives = 191/430 (44%), Gaps = 48/430 (11%)

Query: 283 GTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRN 342
           G   LPF RS     TG         S +NPR   N +T +LD S +YGSS +    LR+
Sbjct: 146 GDVVLPFQRSRWDPETGR--------SPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRS 197

Query: 343 WTSAEGLLRVHARL-RDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVP 401
           ++  +          RDS    L +         AP+P          +  G  R +  P
Sbjct: 198 FSGGQLASGPDPAFPRDSQNPLLMWA--------APDPATGQNGPRGLYAFGAERGNREP 249

Query: 402 SLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPE 461
            L AL  LW R HN  A  L   +  W  + ++Q ARK V A +Q I + +++P  L   
Sbjct: 250 FLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL--- 306

Query: 462 AFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS----------FQEH 511
             Q+ +  Y GY    +P++S  F  A+ +F    + P V   +AS          FQ  
Sbjct: 307 --QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSS 364

Query: 512 PDL---PGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLS 568
             L      W+ +   +P  L     ++ L+ G+ ++ ++L  +D ++ E+L +      
Sbjct: 365 QALRVCNNYWIRE---NP-NLNSTQEVNELLLGMASQISEL--EDNIVVEDLRDYWPGPG 418

Query: 569 NSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKH 628
             S  D  + ++QRGRD GLP Y++     GL      +DL+  +    V +    LY  
Sbjct: 419 KFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNV-DPQVLEATAALYNQ 477

Query: 629 P-DNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSH--VFTDAQRRE 685
               +++ LGGL E+       GPLF+ ++  Q   LRDGD +W+EN+   +F+  +  +
Sbjct: 478 DLSQLELLLGGLLES---HGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIED 534

Query: 686 LEKHSLSRVI 695
           +   +L  V+
Sbjct: 535 IRNTTLRDVL 544


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 39/117 (33%), Positives = 55/117 (47%), Gaps = 7/117 (5%)

Query: 727  MNLEAWRETFPQDDK--CGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQ 784
            +N   W +  P  ++  CG P  +ENG     +      + Y C +GY L G  ++ CT 
Sbjct: 1673 LNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTD 1732

Query: 785  EG-WDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
             G W+   P C DV+ECA G+   C   A C N  G + C C  PY    DG+ C +
Sbjct: 1733 NGSWNGVSPSCLDVDECAVGS--DCSEHASCLNVDGSYICSCVPPYT--GDGKNCAE 1785



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 8/107 (7%)

Query: 741  KCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEG-WDFQPPLCKDVNE 799
            +C  P  + NG     +    + + + C  GY L G  +LTC  +G WD + PLCK VN 
Sbjct: 2890 RCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVN- 2948

Query: 800  CA---DGAHPPCHASARCRNTKGGFQCLCADPYEL-GDDGRTCVDSG 842
            C    D AH   +  +      G  Q  C   Y+L G+  R C+ +G
Sbjct: 2949 CGPPEDLAHGFPNGFSFIHG--GHIQYQCFPGYKLHGNSSRRCLSNG 2993



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 22/55 (40%), Positives = 28/55 (50%), Gaps = 1/55 (1%)

Query: 741  KCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEG-WDFQPPLC 794
            KC  PE++ NG ++    +      YSC  GY LQG   + CT  G WD  PP C
Sbjct: 1904 KCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPAC 1958



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 30/117 (25%), Positives = 47/117 (40%), Gaps = 5/117 (4%)

Query: 732  WRETFP--QDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEG-WD 788
            W   FP  +   CG    + N            V+ YSCR GY +QG   L CT++G W 
Sbjct: 3052 WSSGFPHCEHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWS 3111

Query: 789  FQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGR--TCVDSGR 843
               P+C+ ++  +  +     A+      +   +  C + Y +  D    TC   GR
Sbjct: 3112 QPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGR 3168



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 21/81 (25%), Positives = 38/81 (46%), Gaps = 1/81 (1%)

Query: 742  CGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECA 801
            C  P+ +ENG     + S   +++YSC  G+++ G    TC + GW    P C  + +C 
Sbjct: 2556 CDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPTCMPI-DCG 2614

Query: 802  DGAHPPCHASARCRNTKGGFQ 822
               H       + ++ +G F+
Sbjct: 2615 LPPHIDFGDCTKLKDDQGYFE 2635



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 34/118 (28%), Positives = 50/118 (42%), Gaps = 10/118 (8%)

Query: 730  EAWRETFPQDDK--CGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGW 787
            E W +T  + +K  CG P  VEN            ++ YSC  GY L+G  +  C + G 
Sbjct: 3402 ETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGT 3461

Query: 788  DFQPPLCKDVNE--CADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGR 843
               PP+C+ V    C +G    C     C   +G    LC +P  +      C++ GR
Sbjct: 3462 WTSPPICRAVCRFPCQNGG--ICQRPNACSCPEGWMGRLCEEPICI----LPCLNGGR 3513



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 33/107 (30%), Positives = 45/107 (42%), Gaps = 10/107 (9%)

Query: 742  CGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQE-GWDFQPPLCKDVNEC 800
            C  P  V NG       +    L Y C  GY L G E+ TC  +  WD   P+C  V   
Sbjct: 2775 CKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPV--- 2831

Query: 801  ADGAHPPCHASARCRNTKGGFQ----CLCADPYEL-GDDGRTCVDSG 842
             D + PP  A+ + R  +  FQ      C + + L G   R C+ +G
Sbjct: 2832 -DCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANG 2877



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 1/59 (1%)

Query: 741  KCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEG-WDFQPPLCKDVN 798
            +C  P+ + NG F + +    + + YSC  G+ L+G   LTC + G WD   P C  ++
Sbjct: 2497 ECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIH 2555



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 21/70 (30%), Positives = 32/70 (45%), Gaps = 5/70 (7%)

Query: 732  WRETFPQDD----KCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQ-EG 786
            W   F  +      CG PES E+G  V  + +    ++Y C  GYEL+G  +  C +   
Sbjct: 3227 WEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQ 3286

Query: 787  WDFQPPLCKD 796
            W     +CK+
Sbjct: 3287 WSGGVAICKE 3296



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 34/129 (26%), Positives = 55/129 (42%), Gaps = 15/129 (11%)

Query: 692  SRVICDNTGLTR------VPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDK---- 741
            SR+ C + G         + +D   VG    +  SC ++ G  + +    +  D K    
Sbjct: 1726 SRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAE 1785

Query: 742  ---CGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEG-WDFQPPLCKDV 797
               C  P + ENG       +    + +SC+ GY+L G  ++TC + G W+   P CK V
Sbjct: 1786 PIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAV 1845

Query: 798  NECADGAHP 806
            + C   A P
Sbjct: 1846 S-CGKPAIP 1853



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 24/65 (36%), Positives = 32/65 (49%), Gaps = 4/65 (6%)

Query: 738  QDDKCGFPESVENGDF-VHCEESGRRVLVYSCRHGYELQGREQLTCTQEG-WDFQPPLCK 795
            ++ +C  P    NG   +    +G  V VYSC  GY L+G  +  CT+ G W    PLCK
Sbjct: 3295 KETRCETPLEFLNGKADIENRTTGPNV-VYSCNRGYSLEGPSEAHCTENGTWSHPVPLCK 3353

Query: 796  DVNEC 800
              N C
Sbjct: 3354 P-NPC 3357



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 26/91 (28%), Positives = 41/91 (45%), Gaps = 12/91 (13%)

Query: 741  KCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEG-WDFQPPLCKDVNE 799
            +CG P S+ NG       S   ++ YSC  G+ ++G ++ TC   G W    P C  V+ 
Sbjct: 2145 RCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVS- 2203

Query: 800  CADGAHPPC-------HASARCRNTKGGFQC 823
            C +   PP        H + R   ++  +QC
Sbjct: 2204 CGE---PPKVENGFLEHTTGRIFESEVRYQC 2231



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 22/77 (28%), Positives = 31/77 (40%), Gaps = 3/77 (3%)

Query: 724  ITGMNLEAWRETFP--QDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLT 781
            IT +    W    P  +   CG P   ENG       +    + Y C  GY L G ++ +
Sbjct: 1827 ITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESS 1886

Query: 782  C-TQEGWDFQPPLCKDV 797
            C     W   PP+C+ V
Sbjct: 1887 CLANSSWSHSPPVCEPV 1903



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 27/100 (27%), Positives = 44/100 (44%), Gaps = 9/100 (9%)

Query: 742  CGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEG-WDFQPPLCKDVNEC 800
            CG P ++++        + R  + Y+C+ GY L G + + C  +G W      C  V+ C
Sbjct: 1963 CGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVS-C 2021

Query: 801  ADGAHPPC--HASARCRNTKGGFQCL--CADPYELGDDGR 836
             +   PP   HAS    +   G      C+D Y L D+ +
Sbjct: 2022 DE---PPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQ 2058



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 33/94 (35%), Positives = 42/94 (44%), Gaps = 10/94 (10%)

Query: 766  YSCRHGYELQGREQLTCTQEG-WDFQPPLCKDVNECADGAHPPCHASARCRNTKGG--FQ 822
            Y+C  GYEL G   L C ++G W+   P C  + EC D    P +   R   T  G   Q
Sbjct: 2683 YTCNPGYELLGNPVLICQEDGTWNGSAPSCISI-EC-DLPTAPENGFLRFTETSMGSAVQ 2740

Query: 823  CLCADPYEL-GDDGRTCVD----SGRLPRVTWIS 851
              C   + L G D R C++    SG  PR   IS
Sbjct: 2741 YSCKPGHILAGSDLRLCLENRKWSGASPRCEAIS 2774



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 6/104 (5%)

Query: 741  KCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQ-EGWDFQPPLCKDVNE 799
            +C  P + ENG     E S    + YSC+ G+ L G +   C +   W    P C+ ++ 
Sbjct: 2716 ECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAIS- 2774

Query: 800  CADGAHPPCHASARCRNTK--GGFQCLCADPYEL-GDDGRTCVD 840
                 +P  + S +  N          C   Y L G + RTC D
Sbjct: 2775 -CKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQD 2817



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 21/72 (29%), Positives = 31/72 (43%), Gaps = 4/72 (5%)

Query: 732  WRETFPQ--DDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEG-WD 788
            W    P+    +C  PE + NG       +     +Y+C+ G+EL G     C + G W 
Sbjct: 2428 WSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWL 2487

Query: 789  FQPPLCKDVNEC 800
               P CK + EC
Sbjct: 2488 GGKPTCKAI-EC 2498



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 1/58 (1%)

Query: 741  KCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTC-TQEGWDFQPPLCKDV 797
            KC  P  +EN   +    +   V+ +SC+ G+ LQG   L C   + W+   P+CK V
Sbjct: 2322 KCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIV 2379



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 4/47 (8%)

Query: 742  CGFPESVENGDFVHCE--ESGRRVLVYSCRHGYELQGREQLTCTQEG 786
            CG P  ++NG F+  E  E G +V  + C  GYEL G    TC + G
Sbjct: 2264 CGKPPPIQNG-FMKGENFEVGSKVQFF-CNEGYELVGDSSWTCQKSG 2308



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 13/32 (40%), Positives = 18/32 (56%), Gaps = 3/32 (9%)

Query: 795  KDVNECADGAHPPCHASARCRNTKGGFQCLCA 826
            K+V+EC      PC   A C++    F+CLCA
Sbjct: 1344 KNVDECLS---QPCKNGATCKDGANSFRCLCA 1372


>gi|194328809 latent transforming growth factor beta binding protein
           3 isoform 1 [Homo sapiens]
          Length = 1303

 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 43/128 (33%), Positives = 59/128 (46%), Gaps = 22/128 (17%)

Query: 714 FPEDFESCDSITGMNLEAWRETFPQD-DKCGFPESVENGDFVHCEESGRRVLVYSCRHGY 772
           FP  ++ C+   G  L+A R    +D D+C  P S  +G    CE         +C+ GY
Sbjct: 679 FPGHYK-CNCYPGYRLKASRPPVCEDIDECRDPSSCPDGK---CENKPGSFKCIACQPGY 734

Query: 773 ELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELG 832
             QG                 C+DVNECA+G+  PC +   C N  G F+C CA  Y   
Sbjct: 735 RSQGGGA--------------CRDVNECAEGS--PC-SPGWCENLPGSFRCTCAQGYAPA 777

Query: 833 DDGRTCVD 840
            DGR+C+D
Sbjct: 778 PDGRSCLD 785



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 34/144 (23%), Positives = 56/144 (38%), Gaps = 30/144 (20%)

Query: 695 ICDNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFV 754
           +CDN   +  P      G F      C  ++G +L   R      D+C FP +   GD +
Sbjct: 794 VCDNGICSNTP------GSF-----QCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCI 842

Query: 755 HCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARC 814
           +   S R +    C  G+ L G  +              C+D++EC+      C     C
Sbjct: 843 NTNGSYRCL----CPQGHRLVGGRK--------------CQDIDECSQDP-SLCLPHGAC 883

Query: 815 RNTKGGFQCLCADPYELGDDGRTC 838
           +N +G + C+C + +    D   C
Sbjct: 884 KNLQGSYVCVCDEGFTPTQDQHGC 907



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 29/78 (37%), Positives = 34/78 (43%), Gaps = 7/78 (8%)

Query: 768 CRHGYELQGREQLTC-TQEGWDFQPP--LCKDVNECADGAHPPCHASARCRNTKGGFQCL 824
           C HG  + G    +C    G+   P    C DVNEC   A P       C NT G + C 
Sbjct: 585 CGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECE--AEPCGPGRGICMNTGGSYNCH 642

Query: 825 CADPYEL--GDDGRTCVD 840
           C   Y L  G  GR+CVD
Sbjct: 643 CNRGYRLHVGAGGRSCVD 660



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 46/191 (24%), Positives = 70/191 (36%), Gaps = 25/191 (13%)

Query: 750  NGDFVHCEESGRRVLVYSCRHGY--ELQGREQLTCTQEGWDFQP-------PLCKDVNEC 800
            +G+ + C +    +   +CR+G     +G  +  CT    ++ P       P   DV+EC
Sbjct: 1028 DGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPA-EYSPAQRQCLSPEEMDVDEC 1086

Query: 801  ADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTC----VDSGRLPR---VTWISMS 853
             D   P      RC N  G ++C C  P+  G  GR C      + R P    V W    
Sbjct: 1087 QD---PAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRG 1143

Query: 854  LAALLIGGFAGLTST---VICRWTRTGTKSTLPISETGGGT--PELRCGKHQAVGTSPQR 908
               +  G  AG   T     CR  R       P    G G+  P  +   +    TSP  
Sbjct: 1144 EDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLL 1203

Query: 909  AAAQDSEQESA 919
                  +++S+
Sbjct: 1204 LGKPPRDEDSS 1214



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 15/46 (32%), Positives = 22/46 (47%), Gaps = 3/46 (6%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCV 839
           C+D+NECA    P       C N  G ++C+C   + LG     C+
Sbjct: 353 CQDINECA---MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI 395



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 29/103 (28%), Positives = 38/103 (36%), Gaps = 20/103 (19%)

Query: 747  SVENGDFVHCEESGRRV-----LVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECA 801
            S E+ D   C  SGR V      V  C  G++L             D     C D++EC 
Sbjct: 1214 SEEDSDECRCV-SGRCVPRPGGAVCECPGGFQL-------------DASRARCVDIDECR 1259

Query: 802  D-GAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGR 843
            +         S RC NT G F+C+C   +        CV   R
Sbjct: 1260 ELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRR 1302


>gi|18497288 latent transforming growth factor beta binding protein
           3 isoform 2 [Homo sapiens]
          Length = 1256

 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 43/128 (33%), Positives = 59/128 (46%), Gaps = 22/128 (17%)

Query: 714 FPEDFESCDSITGMNLEAWRETFPQD-DKCGFPESVENGDFVHCEESGRRVLVYSCRHGY 772
           FP  ++ C+   G  L+A R    +D D+C  P S  +G    CE         +C+ GY
Sbjct: 679 FPGHYK-CNCYPGYRLKASRPPVCEDIDECRDPSSCPDGK---CENKPGSFKCIACQPGY 734

Query: 773 ELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELG 832
             QG                 C+DVNECA+G+  PC +   C N  G F+C CA  Y   
Sbjct: 735 RSQGGGA--------------CRDVNECAEGS--PC-SPGWCENLPGSFRCTCAQGYAPA 777

Query: 833 DDGRTCVD 840
            DGR+C+D
Sbjct: 778 PDGRSCLD 785



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 34/144 (23%), Positives = 56/144 (38%), Gaps = 30/144 (20%)

Query: 695 ICDNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFV 754
           +CDN   +  P      G F      C  ++G +L   R      D+C FP +   GD +
Sbjct: 794 VCDNGICSNTP------GSF-----QCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCI 842

Query: 755 HCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARC 814
           +   S R +    C  G+ L G  +              C+D++EC+      C     C
Sbjct: 843 NTNGSYRCL----CPQGHRLVGGRK--------------CQDIDECSQDP-SLCLPHGAC 883

Query: 815 RNTKGGFQCLCADPYELGDDGRTC 838
           +N +G + C+C + +    D   C
Sbjct: 884 KNLQGSYVCVCDEGFTPTQDQHGC 907



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 36/137 (26%), Positives = 52/137 (37%), Gaps = 14/137 (10%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPR------V 847
            C DV+EC D ++  C     C NT+GG++C C  P E     R C+    + R      V
Sbjct: 1034 CVDVDECLDESN--CRNGV-CENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDV 1090

Query: 848  TWISMSLAALLIGGFAGLTST---VICRWTRTGTKSTLPISETGGGT--PELRCGKHQAV 902
             W       +  G  AG   T     CR  R       P    G G+  P  +   +   
Sbjct: 1091 CWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFW 1150

Query: 903  GTSPQRAAAQDSEQESA 919
             TSP        +++S+
Sbjct: 1151 DTSPLLLGKPPRDEDSS 1167



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 29/78 (37%), Positives = 34/78 (43%), Gaps = 7/78 (8%)

Query: 768 CRHGYELQGREQLTC-TQEGWDFQPP--LCKDVNECADGAHPPCHASARCRNTKGGFQCL 824
           C HG  + G    +C    G+   P    C DVNEC   A P       C NT G + C 
Sbjct: 585 CGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECE--AEPCGPGRGICMNTGGSYNCH 642

Query: 825 CADPYEL--GDDGRTCVD 840
           C   Y L  G  GR+CVD
Sbjct: 643 CNRGYRLHVGAGGRSCVD 660



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 15/46 (32%), Positives = 22/46 (47%), Gaps = 3/46 (6%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCV 839
           C+D+NECA    P       C N  G ++C+C   + LG     C+
Sbjct: 353 CQDINECA---MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI 395



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 29/103 (28%), Positives = 38/103 (36%), Gaps = 20/103 (19%)

Query: 747  SVENGDFVHCEESGRRV-----LVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECA 801
            S E+ D   C  SGR V      V  C  G++L             D     C D++EC 
Sbjct: 1167 SEEDSDECRCV-SGRCVPRPGGAVCECPGGFQL-------------DASRARCVDIDECR 1212

Query: 802  D-GAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGR 843
            +         S RC NT G F+C+C   +        CV   R
Sbjct: 1213 ELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRR 1255


>gi|4506265 prostaglandin-endoperoxide synthase 2 precursor [Homo
           sapiens]
          Length = 604

 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 40/142 (28%), Positives = 63/142 (44%), Gaps = 9/142 (6%)

Query: 318 NGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAP 377
           NGL   +D + +YG + A +R+LR +   +   ++       G  Y P V         P
Sbjct: 208 NGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQII-----DGEMYPPTVKDTQAEMIYP 262

Query: 378 EPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEA 437
            P +P   R   F  G      VP L    T+WLREHNR+   LK  +  W  + ++Q +
Sbjct: 263 -PQVPEHLR---FAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTS 318

Query: 438 RKVVGALHQIITLRDYIPRILG 459
           R ++      I + DY+  + G
Sbjct: 319 RLILIGETIKIVIEDYVQHLSG 340


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 25/47 (53%), Positives = 30/47 (63%), Gaps = 1/47 (2%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C DV+ECA G    C  + +C NT G FQC C + YE+  DGRTCVD
Sbjct: 1928 CIDVDECASGNGNLCR-NGQCINTVGSFQCQCNEGYEVAPDGRTCVD 1973



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 46/170 (27%), Positives = 67/170 (39%), Gaps = 37/170 (21%)

Query: 695  ICDNTGLTRVP-------MDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFPES 747
            ICD    T +P        D F      ED ++C  +   +L       P     G  E+
Sbjct: 1248 ICDGGQCTNIPGEYRCLCYDGFMAS---EDMKTCVDVNECDLN------PNICLSGTCEN 1298

Query: 748  VENGDFVHCEE--SGRR-----VLVYSCRHGYELQGREQLTCTQE----------GWDFQ 790
             +     HC+   SG++       +  C  G    G+  + CT            GW   
Sbjct: 1299 TKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAV-CTNTAGSFKCSCSPGWIGD 1357

Query: 791  PPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
               C D++EC++G H  C   A C+NT G ++CLC + Y    DG TC D
Sbjct: 1358 GIKCTDLDECSNGTHM-CSQHADCKNTMGSYRCLCKEGYT--GDGFTCTD 1404



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 28/89 (31%), Positives = 42/89 (47%), Gaps = 6/89 (6%)

Query: 752  DFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHAS 811
            D   C    R+    +C++   L G  +  C   G+  Q   C+D++EC +   P   A 
Sbjct: 1973 DINECLLEPRKCAPGTCQN---LDGSYRCICPP-GYSLQNEKCEDIDECVE--EPEICAL 2026

Query: 812  ARCRNTKGGFQCLCADPYELGDDGRTCVD 840
              C NT+G F+CLC + + L   GR C D
Sbjct: 2027 GTCSNTEGSFKCLCPEGFSLSSSGRRCQD 2055



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 34/98 (34%), Positives = 46/98 (46%), Gaps = 6/98 (6%)

Query: 768  CRHGYELQGREQLTCT-QEGW--DFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCL 824
            CR+G  +  R    C  + G+  D     C D+NEC + A  PC+    C+NT+G +QC 
Sbjct: 2413 CRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNEC-NQAPKPCNFI--CKNTEGSYQCS 2469

Query: 825  CADPYELGDDGRTCVDSGRLPRVTWISMSLAALLIGGF 862
            C   Y L +DGR+C D             L    IGGF
Sbjct: 2470 CPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGF 2507



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 37/127 (29%), Positives = 55/127 (43%), Gaps = 34/127 (26%)

Query: 740  DKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGRE--------------------- 778
            D+C  P+  ++G  ++ + S R      C  GY L G E                     
Sbjct: 2129 DECKEPDVCKHGQCINTDGSYR----CECPFGYILAGNECVDTDECSVGNPCGNGTCKNV 2184

Query: 779  ----QLTCTQEGWDFQPPL-CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGD 833
                + TC +EG++  P + C+D+NECA     P   + RC NT G ++C C   Y L +
Sbjct: 2185 IGGFECTC-EEGFEPGPMMTCEDINECAQN---PLLCAFRCVNTYGSYECKCPVGYVLRE 2240

Query: 834  DGRTCVD 840
            D R C D
Sbjct: 2241 DRRMCKD 2247



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 18/48 (37%), Positives = 25/48 (52%)

Query: 793  LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            +CKD +EC +G H        C+N  G + C+C   Y+   DG  CVD
Sbjct: 2244 MCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVD 2291



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 21/48 (43%), Positives = 27/48 (56%), Gaps = 3/48 (6%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
           CKD+NEC     P    + RC NT G ++C C     +G DGR CVD+
Sbjct: 611 CKDINECET---PGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDT 655



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 23/68 (33%), Positives = 36/68 (52%), Gaps = 5/68 (7%)

Query: 775  QGREQLTCTQEGWDFQPPL--CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELG 832
            +G  + +C Q G+   P    C D++EC D  +P      +C N  G ++CLC D +   
Sbjct: 1216 EGSYECSC-QPGFALMPDQRSCTDIDECED--NPNICDGGQCTNIPGEYRCLCYDGFMAS 1272

Query: 833  DDGRTCVD 840
            +D +TCVD
Sbjct: 1273 EDMKTCVD 1280



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 33/124 (26%), Positives = 49/124 (39%), Gaps = 29/124 (23%)

Query: 721 CDSITGMNLEAWRETFPQDD----KCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQG 776
           C+   G  L+   E    D+     C   E + N     C+          CR GY+   
Sbjct: 474 CECNKGFQLDLRGECIDVDECEKNPCAGGECINNQGSYTCQ----------CRAGYQ--- 520

Query: 777 REQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGR 836
              LT T+         C+D++EC       C+ + RC NT G F C+C   + +  DG+
Sbjct: 521 -STLTRTE---------CRDIDECLQNGRI-CN-NGRCINTDGSFHCVCNAGFHVTRDGK 568

Query: 837 TCVD 840
            C D
Sbjct: 569 NCED 572



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 19/49 (38%), Positives = 24/49 (48%), Gaps = 2/49 (4%)

Query: 792  PLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            P  KD+NEC     P      +CRNT G F+C C   + L  + R C D
Sbjct: 1024 PFFKDINECK--MIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTD 1070



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 17/45 (37%), Positives = 25/45 (55%), Gaps = 2/45 (4%)

Query: 796 DVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           D+NECA    P    +  C N +G ++C+C   YE+   G+ CVD
Sbjct: 723 DINECA--LDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVD 765



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 35/113 (30%), Positives = 48/113 (42%), Gaps = 14/113 (12%)

Query: 737  PQDDKCGFPESVENG-----DFVHCEESGRRVLVYSCRHG--YELQGREQLTCTQEGWDF 789
            P D +C   E  E+G     + +  +E  R  L+  CR G  +  +G  +  C   G   
Sbjct: 1090 PGDFECKCDEGYESGFMMMKNCMDIDECQRDPLL--CRGGVCHNTEGSYRCECPP-GHQL 1146

Query: 790  QPPL--CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
             P +  C D+NEC   AH     + RC N  G +QC C   Y    D   CVD
Sbjct: 1147 SPNISACIDINECELSAH--LCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVD 1197



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 2/44 (4%)

Query: 793  LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGR 836
            +C+D++EC +G  P C  +A C NT G ++C C   Y     G+
Sbjct: 1805 VCEDIDECQNG--PVCQRNAECINTAGSYRCDCKPGYRFTSTGQ 1846



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 20/48 (41%), Positives = 23/48 (47%), Gaps = 3/48 (6%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
            C DVNEC D   P    S  C NT G + C C   +EL      CVD+
Sbjct: 1485 CTDVNECLD---PTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDT 1529



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 18/48 (37%), Positives = 25/48 (52%), Gaps = 2/48 (4%)

Query: 793  LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            + +D++EC +   P      +C NT G FQC C   Y L +D R C D
Sbjct: 1603 ILEDIDECQE--LPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDD 1648



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 3/47 (6%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C+D++EC+      C  +  C N  G F+C+C   ++L  DGR C D
Sbjct: 570 CEDMDECS--IRNMC-LNGMCINEDGSFKCICKPGFQLASDGRYCKD 613



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 17/47 (36%), Positives = 24/47 (51%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C+D++EC     P    +  C NT+G F+C C     L   GR C+D
Sbjct: 908 CEDIDECE--VFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLD 952



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 18/51 (35%), Positives = 23/51 (45%), Gaps = 3/51 (5%)

Query: 793  LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGR 843
            +C DVNEC     P       C NT G + C+C   Y   + G  C+D  R
Sbjct: 1645 VCDDVNECET---PGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRR 1692



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 18/53 (33%), Positives = 25/53 (47%), Gaps = 2/53 (3%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPR 846
            C D NEC +   P   +  +C +T G F CLC   ++  DD   C+D     R
Sbjct: 1847 CNDRNECQE--IPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECER 1897



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 1/47 (2%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C D NEC    +  C +   C+NT G F C C   + L   G +C D
Sbjct: 2522 CIDNNECTSDINL-CGSKGICQNTPGSFTCECQRGFSLDQTGSSCED 2567



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 17/36 (47%), Positives = 21/36 (58%), Gaps = 3/36 (8%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPY 829
            C+D+NEC   A  PC  S  C NT+GG+ C C   Y
Sbjct: 2646 CQDINECGS-AQAPC--SYGCSNTEGGYLCGCPPGY 2678



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 18/66 (27%), Positives = 33/66 (50%), Gaps = 4/66 (6%)

Query: 784  QEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTC--VDS 841
            +EG+      C D++EC++  +     + +C N  GG++C C   +    DG+ C  +D 
Sbjct: 1392 KEGYTGDGFTCTDLDECSENLN--LCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDE 1449

Query: 842  GRLPRV 847
              LP +
Sbjct: 1450 CSLPNI 1455



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 17/47 (36%), Positives = 24/47 (51%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C+DV+EC   A P       C NT G F+C C   ++L +  + C D
Sbjct: 244 CQDVDECQ--AIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCED 288



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 17/47 (36%), Positives = 23/47 (48%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C D+NEC    +     + +CRNT G F C C   +    D +TC D
Sbjct: 763 CVDINECV--LNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCED 807



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 16/48 (33%), Positives = 23/48 (47%), Gaps = 2/48 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
            C D NEC     P    + RC NT+G + C C D +    +   C+D+
Sbjct: 2289 CVDENECQ--TKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDN 2334



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 13/93 (13%)

Query: 752  DFVHCEESGRRVLVYSCRHG--YELQGREQLTCTQEGWDFQPP--LCKDVNECADGAHPP 807
            D   CE S      + C +G    L G+ Q  C   G+   P    C D++EC+   +  
Sbjct: 1155 DINECELSA-----HLCPNGRCVNLIGKYQCACNP-GYHSTPDRLFCVDIDECSI-MNGG 1207

Query: 808  CHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C     C N++G ++C C   + L  D R+C D
Sbjct: 1208 CETF--CTNSEGSYECSCQPGFALMPDQRSCTD 1238



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 3/47 (6%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C+D++EC+    P       C N  G F+C C   YEL   G  C D
Sbjct: 1444 CEDIDECS---LPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTD 1487



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 21/77 (27%), Positives = 36/77 (46%), Gaps = 7/77 (9%)

Query: 768 CRHGYELQGREQLTCT-QEGWDFQPPL--CKDVNECADGAHPPCHASARCRNTKGGFQCL 824
           C +G          CT  +G+ ++P L  C+D++EC      PC  +  C+N+ G F C 
Sbjct: 776 CDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESS---PC-INGVCKNSPGSFICE 831

Query: 825 CADPYELGDDGRTCVDS 841
           C+    L      C+++
Sbjct: 832 CSSESTLDPTKTICIET 848



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 25/75 (33%), Positives = 33/75 (44%), Gaps = 18/75 (24%)

Query: 767  SCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCA 826
            SC  GY LQ        ++G       CKD++ECA   H   +    C NT GGF C C 
Sbjct: 2469 SCPKGYILQ--------EDGRS-----CKDLDECATKQH---NCQFLCVNTIGGFTCKC- 2511

Query: 827  DPYELGDDGRTCVDS 841
             P        +C+D+
Sbjct: 2512 -PPGFTQHHTSCIDN 2525



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 26/88 (29%), Positives = 40/88 (45%), Gaps = 7/88 (7%)

Query: 756  CEESGRRVLVYSCRHGYE-LQGREQLTCTQEGW--DFQPPLCKDVNECADGAHPPCHASA 812
            CE+       + C+HG + + G  + +C Q G+   +Q   C D NEC   AH      A
Sbjct: 2565 CEDVDECEGNHRCQHGCQNIIGGYRCSCPQ-GYLQHYQWNQCVDENECLS-AH--ICGGA 2620

Query: 813  RCRNTKGGFQCLCADPYELGDDGRTCVD 840
             C NT G ++C+C   ++       C D
Sbjct: 2621 SCHNTLGSYKCMCPAGFQYEQFSGGCQD 2648



 Score = 34.3 bits (77), Expect = 0.56
 Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 13/84 (15%)

Query: 768  CRHGYELQGREQLTCT--------QEGWD---FQPPLCKDVNECADGAHPPCHASARCRN 816
            CR   +L GR Q   T         EG++        C D++EC     P       C N
Sbjct: 1074 CRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQ--RDPLLCRGGVCHN 1131

Query: 817  TKGGFQCLCADPYELGDDGRTCVD 840
            T+G ++C C   ++L  +   C+D
Sbjct: 1132 TEGSYRCECPPGHQLSPNISACID 1155



 Score = 33.5 bits (75), Expect = 0.95
 Identities = 14/47 (29%), Positives = 21/47 (44%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C+D++EC+    P       C NT   + C C   +    DG  C+D
Sbjct: 286 CEDIDECS--TIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCID 330



 Score = 33.5 bits (75), Expect = 0.95
 Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 5/48 (10%)

Query: 793  LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            +C D+NEC   A   C  +  CRNT G F C C   + L  +   C+D
Sbjct: 1888 MCLDINECERDA---C-GNGTCRNTIGSFNCRCNHGFILSHN-NDCID 1930


>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 50/168 (29%), Positives = 70/168 (41%), Gaps = 16/168 (9%)

Query: 685  ELEKHSLSRVICDNT--GLTRVPMDAFQVGKFPE--DFESCDSITGM---NLEAWRETFP 737
            E E+H      C NT      +    F++    +  D + C S  G    N   + E   
Sbjct: 1937 ECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEI-- 1994

Query: 738  QDDKCGFPESVE-NGDFVHCEESGRRV-LVYSCRHG--YELQGREQLTCTQEGWDFQPPL 793
               KC   E  E   D  +C ++   V L  SC  G    L+G  +  C   G++ +   
Sbjct: 1995 GSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPP-GYEVKSEN 2053

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
            C D+NEC +   P       C NT GGFQCLC   + L D+GR C D+
Sbjct: 2054 CIDINECDED--PNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDT 2099



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 39/151 (25%), Positives = 61/151 (40%), Gaps = 24/151 (15%)

Query: 697  DNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHC 756
            D TG+  V  D   +G  P    +C ++ G              +C   E  E G  ++C
Sbjct: 2205 DYTGVRCVDTDECSIGN-PCGNGTCTNVIG------------SFECNCNEGFEPGPMMNC 2251

Query: 757  EESGR-----RVLVYSCRHGYELQGREQLTCTQEGWDFQPP--LCKDVNECADGAHPPCH 809
            E+         +  + C + +   G  + TC   G+  +    +CKD++ECA+G H    
Sbjct: 2252 EDINECAQNPLLCAFRCMNTF---GSYECTCPI-GYALREDQKMCKDLDECAEGLHDCES 2307

Query: 810  ASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
                C+N  G F C+C        DG  CVD
Sbjct: 2308 RGMMCKNLIGTFMCICPPGMARRPDGEGCVD 2338



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 24/67 (35%), Positives = 39/67 (58%), Gaps = 4/67 (5%)

Query: 774  LQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGD 833
            + G  + +C +EGW      C D++EC++G H  C  +A+C NT G ++C C++ +    
Sbjct: 1387 IPGSFKCSC-REGWIGNGIKCIDLDECSNGTHQ-CSINAQCVNTPGSYRCACSEGFT--G 1442

Query: 834  DGRTCVD 840
            DG TC D
Sbjct: 1443 DGFTCSD 1449



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 3/75 (4%)

Query: 788  DFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRV 847
            D     C D++EC+    P    +  C+NT+G +QC C   Y L +DG+TC D       
Sbjct: 2483 DISGTSCIDLDECSQSPKP---CNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTK 2539

Query: 848  TWISMSLAALLIGGF 862
                  L    +GGF
Sbjct: 2540 QHNCQFLCVNTLGGF 2554



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C D++EC          + RC NT G FQC+C   +EL  DG+ CVD
Sbjct: 573 CIDIDECIQNG--VLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVD 617



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 25/123 (20%)

Query: 721  CDSITGMNLEAWRETFPQDDKCGFPESV-ENGDFVHCEESGRRVLVYSCRHGYELQGREQ 779
            CD   G  L   RE     ++C   +++  NG  V+   + +     SC  GY      Q
Sbjct: 1183 CDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQ----CSCNPGY------Q 1232

Query: 780  LTCTQEGWDFQPPLCKDVNECA--DGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRT 837
             T  ++G       C D++EC   +G         +C N++G ++C C++ Y L  DGR+
Sbjct: 1233 ATPDRQG-------CTDIDECMIMNGG-----CDTQCTNSEGSYECSCSEGYALMPDGRS 1280

Query: 838  CVD 840
            C D
Sbjct: 1281 CAD 1283



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 20/47 (42%), Positives = 25/47 (53%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C+DVNEC     P    + RC N+KG F C C +   L   GR C+D
Sbjct: 953 CEDVNECE--VFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLD 997



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 21/59 (35%), Positives = 30/59 (50%), Gaps = 6/59 (10%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRVTWISM 852
           C+D+NEC      PC  +  CRN  G F C C+   +L   G  C+DS  L    W+++
Sbjct: 850 CEDINECESN---PC-VNGACRNNLGSFNCECSPGSKLSSTGLICIDS--LKGTCWLNI 902



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 20/49 (40%), Positives = 25/49 (51%), Gaps = 2/49 (4%)

Query: 792  PLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            P  KD+NEC   A P      +CRNT G F+C C   + L  + R C D
Sbjct: 1069 PFYKDINECK--AFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTD 1115



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 21/68 (30%), Positives = 36/68 (52%), Gaps = 5/68 (7%)

Query: 775  QGREQLTCTQEGWDFQPP--LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELG 832
            +G  + +C+ EG+   P    C D++EC +  +P      +C N  G ++CLC D +   
Sbjct: 1261 EGSYECSCS-EGYALMPDGRSCADIDECEN--NPDICDGGQCTNIPGEYRCLCYDGFMAS 1317

Query: 833  DDGRTCVD 840
             D +TC+D
Sbjct: 1318 MDMKTCID 1325



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 18/46 (39%), Positives = 25/46 (54%), Gaps = 2/46 (4%)

Query: 795 KDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           +D+NECA    P   A+  C N +G ++C C   YE    GR C+D
Sbjct: 767 RDINECA--LDPDICANGICENLRGSYRCNCNSGYEPDASGRNCID 810



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 18/48 (37%), Positives = 32/48 (66%), Gaps = 2/48 (4%)

Query: 793  LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            +C+D++EC++G +  C  +A C N+ G ++C CA  ++L  +G  CVD
Sbjct: 1847 VCEDIDECSNGDNL-CQRNADCINSPGSYRCECAAGFKLSPNG-ACVD 1892



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 17/48 (35%), Positives = 25/48 (52%), Gaps = 2/48 (4%)

Query: 793  LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            +C+D++EC   AHP       C NT G + C+C   Y   + G  C+D
Sbjct: 1689 ICEDIDECF--AHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMD 1734



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 19/48 (39%), Positives = 26/48 (54%), Gaps = 3/48 (6%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
           C DV+EC     P    +  C N++G F+C C     +G DGR CVD+
Sbjct: 656 CTDVDECQT---PGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDT 700



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 18/48 (37%), Positives = 26/48 (54%), Gaps = 3/48 (6%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
            C D++ECAD   P    +  C NT G ++C C   ++L   G  CVD+
Sbjct: 1530 CTDIDECAD---PINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDN 1574



 Score = 38.9 bits (89), Expect = 0.023
 Identities = 19/47 (40%), Positives = 26/47 (55%), Gaps = 2/47 (4%)

Query: 795  KDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
            +DVNEC +   P   ++ +C NT G F+C C   Y L   G  CVD+
Sbjct: 2170 EDVNECLES--PGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDT 2214



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 20/47 (42%), Positives = 27/47 (57%), Gaps = 3/47 (6%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C DV+EC  GAH  C   A C N  G F+C C + + +G +G  C+D
Sbjct: 1365 CTDVDECEIGAHN-CDMHASCLNIPGSFKCSCREGW-IG-NGIKCID 1408



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 23/67 (34%), Positives = 30/67 (44%), Gaps = 6/67 (8%)

Query: 778  EQLTCTQEGWDFQPP----LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGD 833
            E  T    G  F+P     + +D++EC +   P       C NT G FQC C   Y L +
Sbjct: 1628 EYYTLCPGGEGFRPNPITIILEDIDECQE--LPGLCQGGNCINTFGSFQCECPQGYYLSE 1685

Query: 834  DGRTCVD 840
            D R C D
Sbjct: 1686 DTRICED 1692



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 26/90 (28%), Positives = 41/90 (45%), Gaps = 7/90 (7%)

Query: 754  VHCEESGRRVLVYSCRHGYE-LQGREQLTCTQEGW--DFQPPLCKDVNECADGAHPPCHA 810
            ++CE+       + C+HG + + G  +  C Q G+   +Q   C D NEC++   P    
Sbjct: 2610 LNCEDVDECDGNHRCQHGCQNILGGYRCGCPQ-GYIQHYQWNQCVDENECSN---PNACG 2665

Query: 811  SARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            SA C NT G ++C C   +        C D
Sbjct: 2666 SASCYNTLGSYKCACPSGFSFDQFSSACHD 2695



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 16/47 (34%), Positives = 24/47 (51%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C+D++EC+    P    +  C NT G + C+C   Y    DG  C+D
Sbjct: 316 CEDIDECS--IIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCID 360



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 20/48 (41%), Positives = 23/48 (47%), Gaps = 3/48 (6%)

Query: 794  CKDVNECADGAHPP-CHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C D NEC  G+ P  C A   C+NT G F C C   + L   G  C D
Sbjct: 2569 CIDNNEC--GSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCED 2614



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 3/47 (6%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C+D++EC+            C N  G F C+C D YEL   G  C D
Sbjct: 1489 CQDIDECS---FQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTD 1532



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 2/47 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C D++EC    +P       C NT+G FQC C   +EL      CVD
Sbjct: 1156 CMDIDECE--RNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVD 1200



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 25/94 (26%), Positives = 40/94 (42%), Gaps = 9/94 (9%)

Query: 741  KCGFPES-VENGDFVHCEESGRRVLVYSCRHG--YELQGREQLTCTQEGWDFQP--PLCK 795
            +CG P+  +++  +  C +        +C     Y   G  +  C   G+ F      C 
Sbjct: 2636 RCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPS-GFSFDQFSSACH 2694

Query: 796  DVNECADGAHPPCHASARCRNTKGGFQCLCADPY 829
            DVNEC+   +P    +  C NT+GG+ C C   Y
Sbjct: 2695 DVNECSSSKNP---CNYGCSNTEGGYLCGCPPGY 2725



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 20/65 (30%), Positives = 32/65 (49%), Gaps = 3/65 (4%)

Query: 776  GREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDG 835
            G  +  C+ EG+      C DV+ECA+  +  C  + +C N  G ++C C   +    D 
Sbjct: 1430 GSYRCACS-EGFTGDGFTCSDVDECAENINL-CE-NGQCLNVPGAYRCECEMGFTPASDS 1486

Query: 836  RTCVD 840
            R+C D
Sbjct: 1487 RSCQD 1491



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 17/45 (37%), Positives = 22/45 (48%), Gaps = 2/45 (4%)

Query: 788  DFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELG 832
            D +   C D++EC     P    S  C NT G F+C C + YE G
Sbjct: 1107 DMEERNCTDIDECR--ISPDLCGSGICVNTPGSFECECFEGYESG 1149



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 15/46 (32%), Positives = 23/46 (50%), Gaps = 2/46 (4%)

Query: 795  KDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            +D++EC     P    + +C NT G F+C C   Y     G +C+D
Sbjct: 2448 RDIDECK--VMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCID 2491



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 24/75 (32%), Positives = 31/75 (41%), Gaps = 18/75 (24%)

Query: 767  SCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCA 826
            SC  GY LQ        ++G       CKD++EC    H   +    C NT GGF C C 
Sbjct: 2516 SCPRGYVLQ--------EDG-----KTCKDLDECQTKQH---NCQFLCVNTLGGFTCKC- 2558

Query: 827  DPYELGDDGRTCVDS 841
             P         C+D+
Sbjct: 2559 -PPGFTQHHTACIDN 2572



 Score = 33.5 bits (75), Expect = 0.95
 Identities = 16/47 (34%), Positives = 23/47 (48%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C+DV+EC   A P       C NT G F+C C   ++  +  + C D
Sbjct: 274 CQDVDECQ--AIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCED 318



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 15/47 (31%), Positives = 20/47 (42%), Gaps = 9/47 (19%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C   N C +G          C N  G F+C+C   + L  +GR C D
Sbjct: 621 CTTTNMCLNGM---------CINEDGSFKCICKPGFVLAPNGRYCTD 658



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 14/47 (29%), Positives = 24/47 (51%), Gaps = 2/47 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C D NEC +  +   H    C + +G +QC+C + ++   D   C+D
Sbjct: 1890 CVDRNECLEIPNVCSHGL--CVDLQGSYQCICHNGFKASQDQTMCMD 1934



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 15/47 (31%), Positives = 21/47 (44%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C D++EC    +     +  CRNT G + C C   Y    +  TC D
Sbjct: 808 CIDIDECL--VNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCED 852



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 15/47 (31%), Positives = 22/47 (46%), Gaps = 4/47 (8%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C DV+EC      PC  +  C NT G + C C   ++     + C+D
Sbjct: 533 CIDVDECTSN---PC-TNGDCVNTPGSYYCKCHAGFQRTPTKQACID 575



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 17/47 (36%), Positives = 20/47 (42%), Gaps = 2/47 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C DVNEC   ++        C NTKG F C C   Y +      C D
Sbjct: 1323 CIDVNECDLNSN--ICMFGECENTKGSFICHCQLGYSVKKGTTGCTD 1367


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 30/82 (36%), Positives = 40/82 (48%), Gaps = 6/82 (7%)

Query: 762  RVLVYSCRHGYELQGREQLTC-TQEGW--DFQPPLCKDVNECADGAHPPCHASARCRNTK 818
            R+L + C HG  +       C  Q G+  D     C D++EC+    P    +  C+NTK
Sbjct: 2368 RMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKP---CTFLCKNTK 2424

Query: 819  GGFQCLCADPYELGDDGRTCVD 840
            G F C C   Y L +DGRTC D
Sbjct: 2425 GSFLCSCPRGYLLEEDGRTCKD 2446



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 30/77 (38%), Positives = 37/77 (48%), Gaps = 7/77 (9%)

Query: 768 CRHG--YELQGREQLTCTQEGWDFQPP--LCKDVNECADGAHPPCHASARCRNTKGGFQC 823
           C HG    + G     C   G+   P    C DV+EC       CH   RC NT+G FQC
Sbjct: 458 CHHGDCVNIPGTYHCRC-YPGFQATPTRQACVDVDECIVSGGL-CHLG-RCVNTEGSFQC 514

Query: 824 LCADPYELGDDGRTCVD 840
           +C   +EL  DG+ CVD
Sbjct: 515 VCNAGFELSPDGKNCVD 531



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 29/77 (37%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 756  CEESGRRVLVYSCRHGYELQ-GREQLTCTQEGWDF-QPPLCKDVNECADGAHPPCHASAR 813
            CE+       + C+HG + Q G  + +C Q      Q   C D NECA    PP   SA 
Sbjct: 2526 CEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECA--LSPPTCGSAS 2583

Query: 814  CRNTKGGFQCLCADPYE 830
            CRNT GGF+C+C   ++
Sbjct: 2584 CRNTLGGFRCVCPSGFD 2600



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 21/48 (43%), Positives = 25/48 (52%), Gaps = 1/48 (2%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
            C D +EC       C     C NT G F CLC D +EL  DG+ CVD+
Sbjct: 1884 CVDFDECTTLVGQVCRFG-HCLNTAGSFHCLCQDGFELTADGKNCVDT 1930



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 26/73 (35%), Positives = 35/73 (47%), Gaps = 5/73 (6%)

Query: 770  HGYELQGREQLTCTQEGWDFQPP--LCKDVNECADGAHPPCHASARCRNTKGGFQCLCAD 827
            H    +G  + +C Q G+   P    C DV+EC +  +P       C N  GG +CLC D
Sbjct: 1169 HCINTEGSYRCSCGQ-GYSLMPDGRACADVDECEE--NPRVCDQGHCTNMPGGHRCLCYD 1225

Query: 828  PYELGDDGRTCVD 840
             +    D RTCVD
Sbjct: 1226 GFMATPDMRTCVD 1238



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 37/135 (27%), Positives = 56/135 (41%), Gaps = 18/135 (13%)

Query: 717  DFESCDSITG--------MNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSC 768
            DF+ C ++ G        +N         QD   GF  + +  + V   E     L  +C
Sbjct: 1886 DFDECTTLVGQVCRFGHCLNTAGSFHCLCQD---GFELTADGKNCVDTNEC--LSLAGTC 1940

Query: 769  RHG--YELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCA 826
              G    L+G  +  C   G+  Q   C D++EC++   P       C N+ G FQCLC 
Sbjct: 1941 LPGTCQNLEGSFRCICPP-GFQVQSDHCIDIDECSE--EPNLCLFGTCTNSPGSFQCLCP 1997

Query: 827  DPYELGDDGRTCVDS 841
              + L D+G  C D+
Sbjct: 1998 PGFVLSDNGHRCFDT 2012



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 19/48 (39%), Positives = 26/48 (54%), Gaps = 3/48 (6%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
           C D++EC     P    +  C NT+G F+C C     +G DGR CVD+
Sbjct: 570 CMDIDECQT---PGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDT 614



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 21/47 (44%), Positives = 25/47 (53%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C DVNEC   + P    + RC NT G F+C C +   L   GR CVD
Sbjct: 867 CDDVNECE--SFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVD 911



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 21/55 (38%), Positives = 30/55 (54%), Gaps = 6/55 (10%)

Query: 789  FQPPL---CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            F+P L   C+D++EC+     P   + RC NT+G + C C   Y L +DG  C D
Sbjct: 2156 FEPGLMMTCEDIDECSLN---PLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRD 2207



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 18/46 (39%), Positives = 26/46 (56%), Gaps = 2/46 (4%)

Query: 795 KDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           +D+NECA    P   A+  C N +G ++C+C   YE G  G+ C D
Sbjct: 681 RDINECA--LDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTD 724



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 21/49 (42%), Positives = 22/49 (44%), Gaps = 2/49 (4%)

Query: 792  PLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            P  KDVNEC     P       CRNT G F C CA  + L    R C D
Sbjct: 982  PFYKDVNECK--VFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTD 1028



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 20/48 (41%), Positives = 25/48 (52%), Gaps = 3/48 (6%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
            C D+NECAD   P    +  C NT G + C C   +EL   G  CVD+
Sbjct: 1443 CTDINECAD---PVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDT 1487



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 27/79 (34%), Positives = 35/79 (44%), Gaps = 12/79 (15%)

Query: 768  CRHGY--ELQGREQLTCTQEGWDFQPPL--CKDVNECA--DGAHPPCHASARCRNTKGGF 821
            C HG    + G  Q +C   G+   P    C D+NEC   +G          C NT+G +
Sbjct: 1124 CPHGQCVNVIGAFQCSC-HAGFQSTPDRQGCVDINECRVQNGG-----CDVHCINTEGSY 1177

Query: 822  QCLCADPYELGDDGRTCVD 840
            +C C   Y L  DGR C D
Sbjct: 1178 RCSCGQGYSLMPDGRACAD 1196



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 42/153 (27%), Positives = 60/153 (39%), Gaps = 27/153 (17%)

Query: 697  DNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHC 756
            D TG+  V  D   VG  P    +C ++ G              +C   +  E G  + C
Sbjct: 2118 DFTGINCVDTDECSVGH-PCGQGTCTNVIG------------GFECACADGFEPGLMMTC 2164

Query: 757  EESGRRVL-----VYSCRHGYELQGREQLTCTQEGWDFQPP--LCKDVNECADGAHPPCH 809
            E+     L      + C   +  +G    TC   G+  +    +C+DV+ECADG    CH
Sbjct: 2165 EDIDECSLNPLLCAFRC---HNTEGSYLCTCPA-GYTLREDGAMCRDVDECADG-QQDCH 2219

Query: 810  A-SARCRNTKGGFQCLCADPYE-LGDDGRTCVD 840
            A    C+N  G F C+C      L   G  C D
Sbjct: 2220 ARGMECKNLIGTFACVCPPGMRPLPGSGEGCTD 2252



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 20/47 (42%), Positives = 24/47 (51%), Gaps = 3/47 (6%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C+DV+ECA G      A   C N  G F+C+C   YEL   G  C D
Sbjct: 1402 CQDVDECAQGN---LCAFGSCENLPGMFRCICNGGYELDRGGGNCTD 1445



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 24/68 (35%), Positives = 31/68 (45%), Gaps = 2/68 (2%)

Query: 795  KDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRVTWISMSL 854
            +DVNECA+  +P    +  C NT G F+C C   Y L   G  CVD+             
Sbjct: 2083 EDVNECAE--NPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGT 2140

Query: 855  AALLIGGF 862
               +IGGF
Sbjct: 2141 CTNVIGGF 2148



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 20/49 (40%), Positives = 24/49 (48%), Gaps = 4/49 (8%)

Query: 793 LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
           +CKDV+EC      PC  S  CRN  G + C C     L   G  C+DS
Sbjct: 763 ICKDVDECLSS---PC-VSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDS 807



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 28/100 (28%), Positives = 43/100 (43%), Gaps = 7/100 (7%)

Query: 743  GFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCT-QEGWDFQPPL--CKDVNE 799
            GF   +  G  +  +E G    +  C +G  +       C    G+++   L  C+DV+E
Sbjct: 1709 GFLTDIHTGKPLDIDECGEIPAI--CANGICINQIGSFRCECPAGFNYNSILLACEDVDE 1766

Query: 800  CADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCV 839
            C      PC  +A C N  G ++C C   Y+L   G  CV
Sbjct: 1767 CGS-RESPCQQNADCINIPGSYRCKCTRGYKLSPGG-ACV 1804



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 20/48 (41%), Positives = 24/48 (50%), Gaps = 3/48 (6%)

Query: 794  CKDVNECADGAHP-PCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C D +EC+  A P PC A   C NT G F+C C   + L   G  C D
Sbjct: 2483 CFDNDECS--AQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCED 2528



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 25/56 (44%), Positives = 29/56 (51%), Gaps = 6/56 (10%)

Query: 786  GWDFQPPL--CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCV 839
            G+DF   L  C++V+ECA G   PC  S  C NT GGF C C   Y     G  CV
Sbjct: 2598 GFDFDQALGGCQEVDECA-GRRGPCSYS--CANTPGGFLCGCPQGYFRAGQGH-CV 2649



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 19/47 (40%), Positives = 24/47 (51%), Gaps = 4/47 (8%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C+DVNEC DG H   H    C+N  GG++C C   +        CVD
Sbjct: 2526 CEDVNEC-DGPHRCQHG---CQNQLGGYRCSCPQGFTQHSQWAQCVD 2568



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 30/98 (30%), Positives = 39/98 (39%), Gaps = 8/98 (8%)

Query: 745  PESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPL--CKDVNECAD 802
            P+     D   CEE+ R   V    H   + G  +  C  +G+   P +  C DV+EC  
Sbjct: 1189 PDGRACADVDECEENPR---VCDQGHCTNMPGGHRCLC-YDGFMATPDMRTCVDVDECDL 1244

Query: 803  GAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
              H   H    C NTKG F C C   Y +      C D
Sbjct: 1245 NPHICLHGD--CENTKGSFVCHCQLGYMVRKGATGCSD 1280



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 33/133 (24%), Positives = 49/133 (36%), Gaps = 27/133 (20%)

Query: 710  QVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFPESV--ENGDFVHCEESGRRVLVYS 767
            Q+G F      C+   G N  +        D+CG  ES   +N D ++   S R      
Sbjct: 1740 QIGSF-----RCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYR----CK 1790

Query: 768  CRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCAD 827
            C  GY+L                   C   NEC +  +   H    C +T+G + CLC  
Sbjct: 1791 CTRGYKLS--------------PGGACVGRNECREIPNVCSHGD--CMDTEGSYMCLCHR 1834

Query: 828  PYELGDDGRTCVD 840
             ++   D   C+D
Sbjct: 1835 GFQASADQTLCMD 1847



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 18/47 (38%), Positives = 22/47 (46%), Gaps = 2/47 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C DV+ECA    P       C NT G ++C C   +EL   G  C D
Sbjct: 1069 CMDVDECA--RDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACED 1113



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 21/47 (44%), Positives = 24/47 (51%), Gaps = 3/47 (6%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C DV+EC  G H  C + A C N  G F C C  P  +G DG  C D
Sbjct: 1278 CSDVDECEVGGHN-CDSHASCLNIPGSFSCRCL-PGWVG-DGFECHD 1321



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 23/67 (34%), Positives = 29/67 (43%), Gaps = 6/67 (8%)

Query: 778  EQLTCTQEGWDFQPP----LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGD 833
            E  T    G  FQP     + +D++EC +   P       C NT G FQC C   Y L +
Sbjct: 1541 EYRTLCPGGEGFQPNRITVILEDIDECQE--LPGLCQGGDCVNTFGSFQCECPPGYHLSE 1598

Query: 834  DGRTCVD 840
              R C D
Sbjct: 1599 HTRICED 1605



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 15/48 (31%), Positives = 24/48 (50%), Gaps = 2/48 (4%)

Query: 793  LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            +C+D++EC+   H        C NT G + C+C   Y   + G  C+D
Sbjct: 1602 ICEDIDECS--THSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMD 1647



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 21/65 (32%), Positives = 33/65 (50%), Gaps = 3/65 (4%)

Query: 776  GREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDG 835
            G  + TC Q G+      C+D +ECA+     C  + +C N  GG++C C   ++  +D 
Sbjct: 1343 GSYRCTCRQ-GFAGDGFFCEDRDECAENVDL-CD-NGQCLNAPGGYRCECEMGFDPTEDH 1399

Query: 836  RTCVD 840
            R C D
Sbjct: 1400 RACQD 1404



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 23/68 (33%), Positives = 29/68 (42%), Gaps = 6/68 (8%)

Query: 775 QGREQLTCTQEGWDFQPP--LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELG 832
           +G  Q  C   G++  P    C D NECA      C  +  C N  G F CLC   + L 
Sbjct: 509 EGSFQCVCNA-GFELSPDGKNCVDHNECATSTM--C-VNGVCLNEDGSFSCLCKPGFLLA 564

Query: 833 DDGRTCVD 840
             G  C+D
Sbjct: 565 PGGHYCMD 572



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 21/78 (26%), Positives = 31/78 (39%), Gaps = 2/78 (2%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRVTWISMS 853
            C D NEC   A P    + RC NT G F+C C + ++       C D  + P    +  +
Sbjct: 2250 CTDDNECH--AQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQT 2307

Query: 854  LAALLIGGFAGLTSTVIC 871
            +   L      +T    C
Sbjct: 2308 MCRSLSSSSEAVTRAECC 2325



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 17/47 (36%), Positives = 20/47 (42%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C+DV+EC   A P       C N  G F C C   + L D    C D
Sbjct: 245 CQDVDECQ--AVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACED 289



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 17/45 (37%), Positives = 20/45 (44%), Gaps = 2/45 (4%)

Query: 788  DFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELG 832
            D Q   C D++EC     P       C NT G F+C C   YE G
Sbjct: 1020 DAQERNCTDIDECR--ISPDLCGQGTCVNTPGSFECECFPGYESG 1062



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 18/53 (33%), Positives = 24/53 (45%), Gaps = 2/53 (3%)

Query: 795  KDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRV 847
            +DV+EC   AH   H    C N+ G F+C C   Y       TC+D     +V
Sbjct: 2362 RDVDECRMLAHLCAHGE--CINSLGSFRCHCQAGYTPDATATTCLDMDECSQV 2412



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 17/55 (30%), Positives = 22/55 (40%), Gaps = 3/55 (5%)

Query: 786  GWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            GW      C D++EC    H  C     C N  G ++C C   +    DG  C D
Sbjct: 1311 GWVGDGFECHDLDECVSQEHR-CSPRGDCLNVPGSYRCTCRQGF--AGDGFFCED 1362


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 32/94 (34%), Positives = 43/94 (45%), Gaps = 16/94 (17%)

Query: 745 PESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGA 804
           P +  NG  +H  +  R +    C  GY+L    +              C+DV+ECA G 
Sbjct: 247 PCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKA-------------CEDVDECAAGL 293

Query: 805 HPPCHASARCRNTKGGFQCLCADPYELGDDGRTC 838
               H    C NT+G F+C+C   YELG DGR C
Sbjct: 294 AQCAHG---CLNTQGSFKCVCHAGYELGADGRQC 324



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 26/75 (34%), Positives = 31/75 (41%), Gaps = 6/75 (8%)

Query: 768 CRHGYELQGREQLTCTQEGW--DFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLC 825
           C HG        L     G+  D     C DV++CAD    PC     C N  GG++C C
Sbjct: 342 CSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADS---PCCQQV-CTNNPGGYECGC 397

Query: 826 ADPYELGDDGRTCVD 840
              Y L  DG  C D
Sbjct: 398 YAGYRLSADGCGCED 412



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 32/120 (26%), Positives = 39/120 (32%), Gaps = 37/120 (30%)

Query: 756 CEESGRRVLVY-SCRHGYELQGREQLTCTQEGWDFQPP------------LCKDVNECAD 802
           C    RR + Y   R  Y  + R  L C + GW  QP             LC     C  
Sbjct: 83  CVGHERRTVYYMGYRQVYTTEARTVLRCCR-GWMQQPDEEGCLSAECSASLCFHGGRCVP 141

Query: 803 GAHPPCHASA-----------------------RCRNTKGGFQCLCADPYELGDDGRTCV 839
           G+  PCH                          RC NT G + C C   + L  D RTC+
Sbjct: 142 GSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCL 201



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 19/45 (42%), Positives = 22/45 (48%), Gaps = 3/45 (6%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTC 838
           C+DV+ECA       H    C N  G FQC C   Y L +D R C
Sbjct: 410 CEDVDECASSRGGCEH---HCTNLAGSFQCSCEAGYRLHEDRRGC 451



 Score = 34.3 bits (77), Expect = 0.56
 Identities = 24/73 (32%), Positives = 29/73 (39%), Gaps = 11/73 (15%)

Query: 768 CRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCAD 827
           C  GYEL G +   C +   +        VN C        H    C +T  G  C C  
Sbjct: 311 CHAGYEL-GADGRQCYRIEMEI-------VNSCEANNGGCSHG---CSHTSAGPLCTCPR 359

Query: 828 PYELGDDGRTCVD 840
            YEL  D RTC+D
Sbjct: 360 GYELDTDQRTCID 372


>gi|157384998 low density lipoprotein receptor-related protein 4
           [Homo sapiens]
          Length = 1905

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 44/160 (27%), Positives = 67/160 (41%), Gaps = 33/160 (20%)

Query: 696 CDNTGLTRVPMDAFQV--GKFPEDFESCDSITGMNLEAWRETFPQ--------DDKCGFP 745
           C+NTG  +  +D F    G+     + C+ +      +  +  PQ        ++ C   
Sbjct: 304 CENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNS--DESPQQNCRPRTGEENC--- 358

Query: 746 ESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAH 805
            +V NG      +  R  +  +C  GY L        T++G       C+DVNECA+  +
Sbjct: 359 -NVNNGGCAQKCQMVRGAVQCTCHTGYRL--------TEDGHT-----CQDVNECAEEGY 404

Query: 806 PPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLP 845
                S  C N++G FQC C   YEL  D R+C   G  P
Sbjct: 405 ----CSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEP 440


>gi|122937283 6720455I24Rik homolog [Homo sapiens]
          Length = 1413

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 27/90 (30%), Positives = 41/90 (45%), Gaps = 4/90 (4%)

Query: 742 CGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL-TCTQEGWDFQPPLCKDVNEC 800
           CG PE V++            V +Y+C  GY L    ++  C   G   +PP C +++EC
Sbjct: 698 CGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDEC 757

Query: 801 ADGAHPPCHASARCRNTKGGFQCLCADPYE 830
                 PC     C++   G+ CLC+  YE
Sbjct: 758 RS---QPCLHGGSCQDRVAGYLCLCSTGYE 784



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 31/108 (28%), Positives = 45/108 (41%), Gaps = 28/108 (25%)

Query: 756 CEESGRRVLVYSCRHGYELQ---GREQLTCTQEGWDFQPPLCK-DVNECADGAHPPCHAS 811
           CE +        C+HG + Q   G     C Q G  +    C+ DV++C+     PC   
Sbjct: 346 CETAQSPCDTKECQHGGQCQVENGSAVCVC-QAG--YTGAACEMDVDDCSPD---PCLNG 399

Query: 812 ARCRNTKGGFQCLCADPY-----ELGD-------------DGRTCVDS 841
             C +  G + CLCA+P+     E GD             +G TCVD+
Sbjct: 400 GSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDA 447


>gi|110347437 latent transforming growth factor beta binding protein
           4 isoform c [Homo sapiens]
          Length = 1557

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 38/126 (30%), Positives = 48/126 (38%), Gaps = 18/126 (14%)

Query: 715 PEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYEL 774
           P  F+     +G +L   R T   +   G P    +G   + E S R     SC  GY  
Sbjct: 746 PGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFR----CSCAPGYRA 801

Query: 775 QGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDD 834
                          +P  C DVNEC +G    C     C NT G F C CA  Y  G  
Sbjct: 802 PSG------------RPGPCADVNECLEGDF--CFPHGECLNTDGSFACTCAPGYRPGPR 847

Query: 835 GRTCVD 840
           G +C+D
Sbjct: 848 GASCLD 853



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 24/47 (51%), Positives = 29/47 (61%), Gaps = 2/47 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C+DV+EC + +   C A A C+N  G FQCLC   YE   DGR CVD
Sbjct: 980  CQDVDECRNRSF--CGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVD 1024



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 36/115 (31%), Positives = 49/115 (42%), Gaps = 26/115 (22%)

Query: 715  PEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCR--HGY 772
            PE+     S  G   E + E   + ++CG  +   NG  V   E       ++CR   GY
Sbjct: 1445 PEEPPEGGSYAGSLAEPYEEL--EAEECGILDGCTNGRCVRVPEG------FTCRCFDGY 1496

Query: 773  ELQGREQLTCTQEGWDFQPPLCKDVNEC--ADGAHPPCHASARCRNTKGGFQCLC 825
             L             D     C D+NEC  A+ A P C  +ARC NT G F+C+C
Sbjct: 1497 RL-------------DMTRMACVDINECDEAEAASPLC-VNARCLNTDGSFRCIC 1537



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 21/47 (44%), Positives = 27/47 (57%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C+DV+ECA    PPC    RC NT+G FQC+C   ++    G  C D
Sbjct: 683 CQDVDECARSP-PPC-TYGRCENTEGSFQCVCPMGFQPNTAGSECED 727



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 26/91 (28%), Positives = 41/91 (45%), Gaps = 8/91 (8%)

Query: 754 VHCEESGRRVLVYSCRHGYELQGREQLTCTQEG-----WDFQPPLCKDVNECADGAHPPC 808
           V C  +G    V+ C+   E  G  +     +G     ++     C+DV+ECA G    C
Sbjct: 243 VCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGR--C 300

Query: 809 HASARCRNTKGGFQCLCADPYELGDDGRTCV 839
                C NT+GG+ C+C D + L     +C+
Sbjct: 301 Q-HGECANTRGGYTCVCPDGFLLDSSRSSCI 330



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 21/54 (38%), Positives = 27/54 (50%), Gaps = 2/54 (3%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRV 847
           C DV+EC     PPC A  RC N+ G F+C+C   +  G     C+D     RV
Sbjct: 518 CIDVDECRR-VPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRV 569



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 20/47 (42%), Positives = 24/47 (51%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C DV+EC     PPC    RC NT G F C+C   Y+    G +C D
Sbjct: 560 CLDVDEC-HRVPPPCDLG-RCENTPGSFLCVCPAGYQAAPHGASCQD 604



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 20/48 (41%), Positives = 23/48 (47%), Gaps = 2/48 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
            C D +ECAD   P C    RC NT G + C C  P  L    R CV +
Sbjct: 1227 CIDNDECAD-EEPACEGG-RCVNTVGSYHCTCEPPLVLDGSQRRCVSN 1272



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 18/47 (38%), Positives = 26/47 (55%), Gaps = 3/47 (6%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C DV+EC++     C  S  C NT G F+C+C   +  G D  +C+D
Sbjct: 851 CLDVDECSE--EDLCQ-SGICTNTDGSFECICPPGHRAGPDLASCLD 894



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 19/46 (41%), Positives = 22/46 (47%), Gaps = 2/46 (4%)

Query: 795 KDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           +DV+ECA    PPC    RC NT G F C C   +     G  C D
Sbjct: 642 EDVDECAQEP-PPC-GPGRCDNTAGSFHCACPAGFRSRGPGAPCQD 685



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 19/49 (38%), Positives = 26/49 (53%), Gaps = 4/49 (8%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCL--CADPYELGDDGRTCVD 840
           C DV+EC +     C  S RC N+ G ++C+  C   Y  G +G TC D
Sbjct: 892 CLDVDECRERGPALC-GSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDD 938



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 19/48 (39%), Positives = 23/48 (47%), Gaps = 2/48 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCA-DPYELGDDGRTCVD 840
           C DV+EC +     C A  RC NT G ++C  A DP      G  C D
Sbjct: 936 CDDVDECQEYGPEICGAQ-RCENTPGSYRCTPACDPGYQPTPGGGCQD 982



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 12/32 (37%), Positives = 17/32 (53%), Gaps = 2/32 (6%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLC 825
           C+DV+EC     P       C+N  G F+C+C
Sbjct: 602 CQDVDECTQS--PGLCGRGACKNLPGSFRCVC 631



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 16/37 (43%), Positives = 20/37 (54%), Gaps = 2/37 (5%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYE 830
            C DVNEC +     C A A C N +G F C+C +  E
Sbjct: 1022 CVDVNEC-ETLQGVCGA-ALCENVEGSFLCVCPNSPE 1056



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 15/49 (30%), Positives = 23/49 (46%), Gaps = 1/49 (2%)

Query: 793  LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
            L +DV+EC       C +   C NT  G+ C C++ Y        C+D+
Sbjct: 1183 LRRDVDECQLFRDQVCKSGV-CVNTAPGYSCYCSNGYYYHTQRLECIDN 1230


>gi|110347412 latent transforming growth factor beta binding protein
           4 isoform b [Homo sapiens]
          Length = 1587

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 38/126 (30%), Positives = 48/126 (38%), Gaps = 18/126 (14%)

Query: 715 PEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYEL 774
           P  F+     +G +L   R T   +   G P    +G   + E S R     SC  GY  
Sbjct: 776 PGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFR----CSCAPGYRA 831

Query: 775 QGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDD 834
                          +P  C DVNEC +G    C     C NT G F C CA  Y  G  
Sbjct: 832 PSG------------RPGPCADVNECLEGDF--CFPHGECLNTDGSFACTCAPGYRPGPR 877

Query: 835 GRTCVD 840
           G +C+D
Sbjct: 878 GASCLD 883



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 24/47 (51%), Positives = 29/47 (61%), Gaps = 2/47 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C+DV+EC + +   C A A C+N  G FQCLC   YE   DGR CVD
Sbjct: 1010 CQDVDECRNRSF--CGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVD 1054



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 36/115 (31%), Positives = 49/115 (42%), Gaps = 26/115 (22%)

Query: 715  PEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCR--HGY 772
            PE+     S  G   E + E   + ++CG  +   NG  V   E       ++CR   GY
Sbjct: 1475 PEEPPEGGSYAGSLAEPYEEL--EAEECGILDGCTNGRCVRVPEG------FTCRCFDGY 1526

Query: 773  ELQGREQLTCTQEGWDFQPPLCKDVNEC--ADGAHPPCHASARCRNTKGGFQCLC 825
             L             D     C D+NEC  A+ A P C  +ARC NT G F+C+C
Sbjct: 1527 RL-------------DMTRMACVDINECDEAEAASPLC-VNARCLNTDGSFRCIC 1567



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 21/47 (44%), Positives = 27/47 (57%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C+DV+ECA    PPC    RC NT+G FQC+C   ++    G  C D
Sbjct: 713 CQDVDECARSP-PPC-TYGRCENTEGSFQCVCPMGFQPNTAGSECED 757



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 26/91 (28%), Positives = 41/91 (45%), Gaps = 8/91 (8%)

Query: 754 VHCEESGRRVLVYSCRHGYELQGREQLTCTQEG-----WDFQPPLCKDVNECADGAHPPC 808
           V C  +G    V+ C+   E  G  +     +G     ++     C+DV+ECA G    C
Sbjct: 273 VCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGR--C 330

Query: 809 HASARCRNTKGGFQCLCADPYELGDDGRTCV 839
                C NT+GG+ C+C D + L     +C+
Sbjct: 331 Q-HGECANTRGGYTCVCPDGFLLDSSRSSCI 360



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 21/54 (38%), Positives = 27/54 (50%), Gaps = 2/54 (3%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRV 847
           C DV+EC     PPC A  RC N+ G F+C+C   +  G     C+D     RV
Sbjct: 548 CIDVDECRR-VPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRV 599



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 20/47 (42%), Positives = 24/47 (51%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C DV+EC     PPC    RC NT G F C+C   Y+    G +C D
Sbjct: 590 CLDVDEC-HRVPPPCDLG-RCENTPGSFLCVCPAGYQAAPHGASCQD 634



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 20/48 (41%), Positives = 23/48 (47%), Gaps = 2/48 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
            C D +ECAD   P C    RC NT G + C C  P  L    R CV +
Sbjct: 1257 CIDNDECAD-EEPACEGG-RCVNTVGSYHCTCEPPLVLDGSQRRCVSN 1302



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 18/47 (38%), Positives = 26/47 (55%), Gaps = 3/47 (6%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C DV+EC++     C  S  C NT G F+C+C   +  G D  +C+D
Sbjct: 881 CLDVDECSE--EDLCQ-SGICTNTDGSFECICPPGHRAGPDLASCLD 924



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 19/46 (41%), Positives = 22/46 (47%), Gaps = 2/46 (4%)

Query: 795 KDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           +DV+ECA    PPC    RC NT G F C C   +     G  C D
Sbjct: 672 EDVDECAQEP-PPC-GPGRCDNTAGSFHCACPAGFRSRGPGAPCQD 715



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 19/49 (38%), Positives = 26/49 (53%), Gaps = 4/49 (8%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCL--CADPYELGDDGRTCVD 840
           C DV+EC +     C  S RC N+ G ++C+  C   Y  G +G TC D
Sbjct: 922 CLDVDECRERGPALC-GSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDD 968



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 19/48 (39%), Positives = 23/48 (47%), Gaps = 2/48 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCA-DPYELGDDGRTCVD 840
            C DV+EC +     C A  RC NT G ++C  A DP      G  C D
Sbjct: 966  CDDVDECQEYGPEICGAQ-RCENTPGSYRCTPACDPGYQPTPGGGCQD 1012



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 12/32 (37%), Positives = 17/32 (53%), Gaps = 2/32 (6%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLC 825
           C+DV+EC     P       C+N  G F+C+C
Sbjct: 632 CQDVDECTQS--PGLCGRGACKNLPGSFRCVC 661



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 16/37 (43%), Positives = 20/37 (54%), Gaps = 2/37 (5%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYE 830
            C DVNEC +     C A A C N +G F C+C +  E
Sbjct: 1052 CVDVNEC-ETLQGVCGA-ALCENVEGSFLCVCPNSPE 1086



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 15/49 (30%), Positives = 23/49 (46%), Gaps = 1/49 (2%)

Query: 793  LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
            L +DV+EC       C +   C NT  G+ C C++ Y        C+D+
Sbjct: 1213 LRRDVDECQLFRDQVCKSGV-CVNTAPGYSCYCSNGYYYHTQRLECIDN 1260


>gi|110347431 latent transforming growth factor beta binding protein
           4 isoform a [Homo sapiens]
          Length = 1624

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 38/126 (30%), Positives = 48/126 (38%), Gaps = 18/126 (14%)

Query: 715 PEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYEL 774
           P  F+     +G +L   R T   +   G P    +G   + E S R     SC  GY  
Sbjct: 813 PGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFR----CSCAPGYRA 868

Query: 775 QGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDD 834
                          +P  C DVNEC +G    C     C NT G F C CA  Y  G  
Sbjct: 869 PSG------------RPGPCADVNECLEGDF--CFPHGECLNTDGSFACTCAPGYRPGPR 914

Query: 835 GRTCVD 840
           G +C+D
Sbjct: 915 GASCLD 920



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 24/47 (51%), Positives = 29/47 (61%), Gaps = 2/47 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C+DV+EC + +   C A A C+N  G FQCLC   YE   DGR CVD
Sbjct: 1047 CQDVDECRNRSF--CGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVD 1091



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 36/115 (31%), Positives = 49/115 (42%), Gaps = 26/115 (22%)

Query: 715  PEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCR--HGY 772
            PE+     S  G   E + E   + ++CG  +   NG  V   E       ++CR   GY
Sbjct: 1512 PEEPPEGGSYAGSLAEPYEEL--EAEECGILDGCTNGRCVRVPEG------FTCRCFDGY 1563

Query: 773  ELQGREQLTCTQEGWDFQPPLCKDVNEC--ADGAHPPCHASARCRNTKGGFQCLC 825
             L             D     C D+NEC  A+ A P C  +ARC NT G F+C+C
Sbjct: 1564 RL-------------DMTRMACVDINECDEAEAASPLC-VNARCLNTDGSFRCIC 1604



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 21/47 (44%), Positives = 27/47 (57%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C+DV+ECA    PPC    RC NT+G FQC+C   ++    G  C D
Sbjct: 750 CQDVDECARSP-PPC-TYGRCENTEGSFQCVCPMGFQPNTAGSECED 794



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 26/91 (28%), Positives = 41/91 (45%), Gaps = 8/91 (8%)

Query: 754 VHCEESGRRVLVYSCRHGYELQGREQLTCTQEG-----WDFQPPLCKDVNECADGAHPPC 808
           V C  +G    V+ C+   E  G  +     +G     ++     C+DV+ECA G    C
Sbjct: 310 VCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGR--C 367

Query: 809 HASARCRNTKGGFQCLCADPYELGDDGRTCV 839
                C NT+GG+ C+C D + L     +C+
Sbjct: 368 Q-HGECANTRGGYTCVCPDGFLLDSSRSSCI 397



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 21/54 (38%), Positives = 27/54 (50%), Gaps = 2/54 (3%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRV 847
           C DV+EC     PPC A  RC N+ G F+C+C   +  G     C+D     RV
Sbjct: 585 CIDVDECRR-VPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRV 636



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 20/47 (42%), Positives = 24/47 (51%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C DV+EC     PPC    RC NT G F C+C   Y+    G +C D
Sbjct: 627 CLDVDEC-HRVPPPCDLG-RCENTPGSFLCVCPAGYQAAPHGASCQD 671



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 20/48 (41%), Positives = 23/48 (47%), Gaps = 2/48 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
            C D +ECAD   P C    RC NT G + C C  P  L    R CV +
Sbjct: 1294 CIDNDECAD-EEPACEGG-RCVNTVGSYHCTCEPPLVLDGSQRRCVSN 1339



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 18/47 (38%), Positives = 26/47 (55%), Gaps = 3/47 (6%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C DV+EC++     C  S  C NT G F+C+C   +  G D  +C+D
Sbjct: 918 CLDVDECSE--EDLCQ-SGICTNTDGSFECICPPGHRAGPDLASCLD 961



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 19/46 (41%), Positives = 22/46 (47%), Gaps = 2/46 (4%)

Query: 795 KDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           +DV+ECA    PPC    RC NT G F C C   +     G  C D
Sbjct: 709 EDVDECAQEP-PPC-GPGRCDNTAGSFHCACPAGFRSRGPGAPCQD 752



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 19/49 (38%), Positives = 26/49 (53%), Gaps = 4/49 (8%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCL--CADPYELGDDGRTCVD 840
            C DV+EC +     C  S RC N+ G ++C+  C   Y  G +G TC D
Sbjct: 959  CLDVDECRERGPALC-GSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDD 1005



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 19/48 (39%), Positives = 23/48 (47%), Gaps = 2/48 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCA-DPYELGDDGRTCVD 840
            C DV+EC +     C A  RC NT G ++C  A DP      G  C D
Sbjct: 1003 CDDVDECQEYGPEICGAQ-RCENTPGSYRCTPACDPGYQPTPGGGCQD 1049



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 12/32 (37%), Positives = 17/32 (53%), Gaps = 2/32 (6%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLC 825
           C+DV+EC     P       C+N  G F+C+C
Sbjct: 669 CQDVDECTQS--PGLCGRGACKNLPGSFRCVC 698



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 16/37 (43%), Positives = 20/37 (54%), Gaps = 2/37 (5%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYE 830
            C DVNEC +     C A A C N +G F C+C +  E
Sbjct: 1089 CVDVNEC-ETLQGVCGA-ALCENVEGSFLCVCPNSPE 1123



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 15/49 (30%), Positives = 23/49 (46%), Gaps = 1/49 (2%)

Query: 793  LCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDS 841
            L +DV+EC       C +   C NT  G+ C C++ Y        C+D+
Sbjct: 1250 LRRDVDECQLFRDQVCKSGV-CVNTAPGYSCYCSNGYYYHTQRLECIDN 1297


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 30/90 (33%), Positives = 42/90 (46%), Gaps = 7/90 (7%)

Query: 755  HCEESGRRVLVYS-CRHGYELQGREQLTCT-QEGWDFQP-PLCKDVNECADGAHPP-CHA 810
            HCE+    +   S C+ G  +       CT  +G+       C+D+NEC    HP  C  
Sbjct: 1159 HCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECE---HPGLCGP 1215

Query: 811  SARCRNTKGGFQCLCADPYELGDDGRTCVD 840
               C NT+G F C+C   + +  DGRTC D
Sbjct: 1216 QGECLNTEGSFHCVCQQGFSISADGRTCED 1245



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 2/47 (4%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C+D++EC +     C +   C NT G F+CLC   ++   DG+ CVD
Sbjct: 1243 CEDIDECVNNT--VCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVD 1287



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 5/76 (6%)

Query: 768 CRHGYELQGREQLTCT-QEGWDF--QPPLCKDVNECADGAHPPCHASARCRNTKGGFQCL 824
           C  G+ +    + TC   EG+ F  Q   C D++EC    H    +  RC NT+G F C+
Sbjct: 885 CGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQH--LCSQGRCENTEGSFLCI 942

Query: 825 CADPYELGDDGRTCVD 840
           C   +   ++G  C+D
Sbjct: 943 CPAGFMASEEGTNCID 958



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 30/101 (29%), Positives = 41/101 (40%), Gaps = 20/101 (19%)

Query: 740  DKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNE 799
            D+C       NG   + E S R     +C  GY+L   +               C+D++E
Sbjct: 1082 DECQQGNLCVNGQCKNTEGSFR----CTCGQGYQLSAAKDQ-------------CEDIDE 1124

Query: 800  CADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            C    H    A  +CRNT+G FQC+C   Y     G  C D
Sbjct: 1125 CQ---HRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCED 1162



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 30/102 (29%), Positives = 38/102 (37%), Gaps = 18/102 (17%)

Query: 738  QDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDV 797
            Q ++CG     ENG  V  +E         C  GY L             D     C DV
Sbjct: 1622 QAEECGILNGCENGRCVRVQEG----YTCDCFDGYHL-------------DTAKMTCVDV 1664

Query: 798  NECAD-GAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTC 838
            NEC +         +A+C NT G ++CLC   Y   D    C
Sbjct: 1665 NECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYC 1706



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 21/75 (28%), Positives = 34/75 (45%), Gaps = 6/75 (8%)

Query: 768  CRHGYELQGREQLTCTQEGWDFQPPL---CKDVNECADGAHPPCHASARCRNTKGGFQCL 824
            C++G+ L  R    C  +   +  P+   C D++EC D   P      +C NT+G + C 
Sbjct: 1437 CKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQD---PSSCIDGQCVNTEGSYNCF 1493

Query: 825  CADPYELGDDGRTCV 839
            C  P  L    + C+
Sbjct: 1494 CTHPMVLDASEKRCI 1508



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 8/61 (13%)

Query: 782  CTQ--EGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCV 839
            CT+   GW+ Q   C DV+EC +   P   A+  C N +G + C C   Y    D + C 
Sbjct: 1026 CTEGFRGWNGQ---CLDVDECLE---PNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCR 1079

Query: 840  D 840
            D
Sbjct: 1080 D 1080



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 14/50 (28%), Positives = 22/50 (44%), Gaps = 2/50 (4%)

Query: 791 PPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           P    ++NEC    +P    +  C N    + C+C + Y   +  R CVD
Sbjct: 869 PTQVTEINECT--VNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVD 916



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 16/34 (47%), Positives = 19/34 (55%), Gaps = 2/34 (5%)

Query: 794  CKDVNECADGAHPPCHASARCRNTKGGFQCLCAD 827
            C DVNEC +     C   A C N +G F C+CAD
Sbjct: 1285 CVDVNEC-ELLSGVC-GEAFCENVEGSFLCVCAD 1316



 Score = 31.2 bits (69), Expect = 4.7
 Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 15/89 (16%)

Query: 738 QDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDV 797
           Q+D CG   +  +  F  C++  ++       HGY     + + C           C+D+
Sbjct: 578 QEDCCGTVGT--SWGFNKCQKCPKK----PSYHGYN----QMMECLPGYKRVNNTFCQDI 627

Query: 798 NECA-DGAHPPCHASARCRNTKGGFQCLC 825
           NEC   G  P    +  C NT G ++C C
Sbjct: 628 NECQLQGVCP----NGECLNTMGSYRCTC 652



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 17/53 (32%), Positives = 22/53 (41%), Gaps = 9/53 (16%)

Query: 788  DFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            + Q   C  +N C +G         RC   + G+ C C D Y L     TCVD
Sbjct: 1620 ELQAEECGILNGCENG---------RCVRVQEGYTCDCFDGYHLDTAKMTCVD 1663


>gi|46249412 latent transforming growth factor beta binding protein
           1 isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 30/90 (33%), Positives = 42/90 (46%), Gaps = 7/90 (7%)

Query: 755 HCEESGRRVLVYS-CRHGYELQGREQLTCT-QEGWDFQP-PLCKDVNECADGAHPP-CHA 810
           HCE+    +   S C+ G  +       CT  +G+       C+D+NEC    HP  C  
Sbjct: 833 HCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECE---HPGLCGP 889

Query: 811 SARCRNTKGGFQCLCADPYELGDDGRTCVD 840
              C NT+G F C+C   + +  DGRTC D
Sbjct: 890 QGECLNTEGSFHCVCQQGFSISADGRTCED 919



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 2/47 (4%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C+D++EC +     C +   C NT G F+CLC   ++   DG+ CVD
Sbjct: 917 CEDIDECVNNT--VCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVD 961



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 5/76 (6%)

Query: 768 CRHGYELQGREQLTCT-QEGWDF--QPPLCKDVNECADGAHPPCHASARCRNTKGGFQCL 824
           C  G+ +    + TC   EG+ F  Q   C D++EC    H    +  RC NT+G F C+
Sbjct: 559 CGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQH--LCSQGRCENTEGSFLCI 616

Query: 825 CADPYELGDDGRTCVD 840
           C   +   ++G  C+D
Sbjct: 617 CPAGFMASEEGTNCID 632



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 30/101 (29%), Positives = 41/101 (40%), Gaps = 20/101 (19%)

Query: 740 DKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNE 799
           D+C       NG   + E S R     +C  GY+L   +               C+D++E
Sbjct: 756 DECQQGNLCVNGQCKNTEGSFR----CTCGQGYQLSAAKDQ-------------CEDIDE 798

Query: 800 CADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           C    H    A  +CRNT+G FQC+C   Y     G  C D
Sbjct: 799 CQ---HRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCED 836



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 30/102 (29%), Positives = 38/102 (37%), Gaps = 18/102 (17%)

Query: 738  QDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDV 797
            Q ++CG     ENG  V  +E         C  GY L             D     C DV
Sbjct: 1296 QAEECGILNGCENGRCVRVQEG----YTCDCFDGYHL-------------DTAKMTCVDV 1338

Query: 798  NECAD-GAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTC 838
            NEC +         +A+C NT G ++CLC   Y   D    C
Sbjct: 1339 NECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYC 1380



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 21/75 (28%), Positives = 34/75 (45%), Gaps = 6/75 (8%)

Query: 768  CRHGYELQGREQLTCTQEGWDFQPPL---CKDVNECADGAHPPCHASARCRNTKGGFQCL 824
            C++G+ L  R    C  +   +  P+   C D++EC D   P      +C NT+G + C 
Sbjct: 1111 CKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQD---PSSCIDGQCVNTEGSYNCF 1167

Query: 825  CADPYELGDDGRTCV 839
            C  P  L    + C+
Sbjct: 1168 CTHPMVLDASEKRCI 1182



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 8/61 (13%)

Query: 782 CTQ--EGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCV 839
           CT+   GW+ Q   C DV+EC +   P   A+  C N +G + C C   Y    D + C 
Sbjct: 700 CTEGFRGWNGQ---CLDVDECLE---PNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCR 753

Query: 840 D 840
           D
Sbjct: 754 D 754



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 14/50 (28%), Positives = 22/50 (44%), Gaps = 2/50 (4%)

Query: 791 PPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
           P    ++NEC    +P    +  C N    + C+C + Y   +  R CVD
Sbjct: 543 PTQVTEINECT--VNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVD 590



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 16/34 (47%), Positives = 19/34 (55%), Gaps = 2/34 (5%)

Query: 794 CKDVNECADGAHPPCHASARCRNTKGGFQCLCAD 827
           C DVNEC +     C   A C N +G F C+CAD
Sbjct: 959 CVDVNEC-ELLSGVC-GEAFCENVEGSFLCVCAD 990



 Score = 31.2 bits (69), Expect = 4.7
 Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 15/89 (16%)

Query: 738 QDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDV 797
           Q+D CG   +  +  F  C++  ++       HGY     + + C           C+D+
Sbjct: 252 QEDCCGTVGT--SWGFNKCQKCPKK----PSYHGYN----QMMECLPGYKRVNNTFCQDI 301

Query: 798 NECA-DGAHPPCHASARCRNTKGGFQCLC 825
           NEC   G  P    +  C NT G ++C C
Sbjct: 302 NECQLQGVCP----NGECLNTMGSYRCTC 326



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 17/53 (32%), Positives = 22/53 (41%), Gaps = 9/53 (16%)

Query: 788  DFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD 840
            + Q   C  +N C +G         RC   + G+ C C D Y L     TCVD
Sbjct: 1294 ELQAEECGILNGCENG---------RCVRVQEGYTCDCFDGYHLDTAKMTCVD 1337


>gi|18104969 prostaglandin-endoperoxide synthase 1 isoform 2
           precursor [Homo sapiens]
          Length = 562

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 39/136 (28%), Positives = 61/136 (44%), Gaps = 9/136 (6%)

Query: 324 LDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPG 383
           +D   +YG +  LERQ +     +G L+        G  Y P V   AP       GIP 
Sbjct: 227 VDLGHIYGDN--LERQYQLRLFKDGKLKYQVL---DGEMYPPSVE-EAPVLMHYPRGIPP 280

Query: 384 ETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGA 443
           +++      G      +P L    TLWLREHNR+   LKA +  W  + ++Q  R ++  
Sbjct: 281 QSQ---MAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIG 337

Query: 444 LHQIITLRDYIPRILG 459
               I + +Y+ ++ G
Sbjct: 338 ETIKIVIEEYVQQLSG 353


>gi|18104967 prostaglandin-endoperoxide synthase 1 isoform 1
           precursor [Homo sapiens]
          Length = 599

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 39/136 (28%), Positives = 61/136 (44%), Gaps = 9/136 (6%)

Query: 324 LDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPG 383
           +D   +YG +  LERQ +     +G L+        G  Y P V   AP       GIP 
Sbjct: 227 VDLGHIYGDN--LERQYQLRLFKDGKLKYQVL---DGEMYPPSVE-EAPVLMHYPRGIPP 280

Query: 384 ETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGA 443
           +++      G      +P L    TLWLREHNR+   LKA +  W  + ++Q  R ++  
Sbjct: 281 QSQ---MAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIG 337

Query: 444 LHQIITLRDYIPRILG 459
               I + +Y+ ++ G
Sbjct: 338 ETIKIVIEEYVQQLSG 353


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,354,601
Number of Sequences: 37866
Number of extensions: 1903799
Number of successful extensions: 6639
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 132
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 5202
Number of HSP's gapped (non-prelim): 1220
length of query: 933
length of database: 18,247,518
effective HSP length: 112
effective length of query: 821
effective length of database: 14,006,526
effective search space: 11499357846
effective search space used: 11499357846
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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