Search of human proteins with 27734955

Search of human proteins with 27734955

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27734955 EPH receptor A6 isoform b [Homo sapiens]
         (334 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27734955 EPH receptor A6 isoform b [Homo sapiens]                  675   0.0  
gi|145312251 EPH receptor A6 isoform a [Homo sapiens]                 596   e-170
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap...   345   2e-95
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi...   339   2e-93
gi|4758282 ephrin receptor EphA7 [Homo sapiens]                       339   2e-93
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap...   336   2e-92
gi|4758280 ephrin receptor EphA4 [Homo sapiens]                       321   7e-88
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi...   294   9e-80
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap...   290   9e-79
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]             290   1e-78
gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]            285   3e-77
gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo sapi...   285   5e-77
gi|32528301 EPH receptor B4 precursor [Homo sapiens]                  276   2e-74
gi|32967311 ephrin receptor EphA2 [Homo sapiens]                      265   3e-71
gi|221316650 ephrin receptor EphA1 [Homo sapiens]                     193   2e-49
gi|150456460 EPH receptor A10 isofom 3 [Homo sapiens]                 190   2e-48
gi|194097332 ephrin receptor EphB6 precursor [Homo sapiens]           185   4e-47
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]   111   8e-25
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]   111   8e-25
gi|4503787 fyn-related kinase [Homo sapiens]                          110   1e-24
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       110   2e-24
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               109   4e-24
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   108   5e-24
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   108   5e-24
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              108   9e-24
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...   107   2e-23
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...   107   2e-23
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   107   2e-23
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...   107   2e-23
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                107   2e-23

>gi|27734955 EPH receptor A6 isoform b [Homo sapiens]
          Length = 334

 Score =  675 bits (1741), Expect = 0.0
 Identities = 334/334 (100%), Positives = 334/334 (100%)

Query: 1   MKDSPFQVTKLYWLNEKWDFIASASDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGR 60
           MKDSPFQVTKLYWLNEKWDFIASASDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGR
Sbjct: 1   MKDSPFQVTKLYWLNEKWDFIASASDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGR 60

Query: 61  CQWYIKAKMKSEEKRRNHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIE 120
           CQWYIKAKMKSEEKRRNHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIE
Sbjct: 61  CQWYIKAKMKSEEKRRNHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIE 120

Query: 121 RVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIR 180
           RVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIR
Sbjct: 121 RVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIR 180

Query: 181 LEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYM 240
           LEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYM
Sbjct: 181 LEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYM 240

Query: 241 ENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKV 300
           ENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKV
Sbjct: 241 ENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKV 300

Query: 301 SDFGLSRVLEDDPEAAYTTTDLFQTLTLNLCYSA 334
           SDFGLSRVLEDDPEAAYTTTDLFQTLTLNLCYSA
Sbjct: 301 SDFGLSRVLEDDPEAAYTTTDLFQTLTLNLCYSA 334


>gi|145312251 EPH receptor A6 isoform a [Homo sapiens]
          Length = 1130

 Score =  596 bits (1536), Expect = e-170
 Identities = 298/308 (96%), Positives = 302/308 (98%), Gaps = 2/308 (0%)

Query: 15  NEKWDFIAS--ASDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSE 72
           ++K++F      SDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSE
Sbjct: 621 SQKFEFETGDETSDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSE 680

Query: 73  EKRRNHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVC 132
           EKRRNHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVC
Sbjct: 681 EKRRNHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVC 740

Query: 133 SGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPA 192
           SGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPA
Sbjct: 741 SGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPA 800

Query: 193 IGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKH 252
           IGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKH
Sbjct: 801 IGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKH 860

Query: 253 DGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD 312
           DGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD
Sbjct: 861 DGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD 920

Query: 313 PEAAYTTT 320
           PEAAYTTT
Sbjct: 921 PEAAYTTT 928


>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo
           sapiens]
          Length = 1015

 Score =  345 bits (886), Expect = 2e-95
 Identities = 185/292 (63%), Positives = 213/292 (72%), Gaps = 44/292 (15%)

Query: 28  AAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEKRRNHLQNGHLRFP 87
           +++Q QI VIA +   G  LL ++ +  L++GR   Y KAK   EE++  H  NGH++ P
Sbjct: 566 SSDQSQIPVIAVSVTVGVILLAVV-IGVLLSGRRCGYSKAKQDPEEEKM-HFHNGHIKLP 623

Query: 88  GIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVA 147
           G++TYIDP TYEDP+ AVHEFAKEI+ S I IERVIGAGEFGEVCSGRLK PGKRE+PVA
Sbjct: 624 GVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVA 683

Query: 148 IKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGF 207
           IKTLK G+ ++QRRDFL EASIMGQFDHPNII LEGVVTK                    
Sbjct: 684 IKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTK-------------------- 723

Query: 208 LNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRG 267
                                  +PVMIV EYMENGSLD+FL+K+DG FTVIQLVGMLRG
Sbjct: 724 ----------------------SKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRG 761

Query: 268 IASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTT 319
           I++GMKYLSDMGYVHRDLAARNIL+NSNLVCKVSDFGLSRVLEDDPEAAYTT
Sbjct: 762 ISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTT 813


>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
           sapiens]
          Length = 983

 Score =  339 bits (869), Expect = 2e-93
 Identities = 184/307 (59%), Positives = 217/307 (70%), Gaps = 48/307 (15%)

Query: 15  NEKWDFIASASD--MAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSE 72
           + K++F  S     ++ E  Q+++IA +A     LL ++   +++ GR   Y K+K  ++
Sbjct: 521 SRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVV--IYVLIGRFCGY-KSKHGAD 577

Query: 73  EKRRNHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVC 132
           EKR  H  NGHL+ PG++TY+DP TYEDP+ AVHEFAKE+D + I I++V+GAGEFGEVC
Sbjct: 578 EKRL-HFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVC 636

Query: 133 SGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPA 192
           SGRLK P K+EI VAIKTLK G+ ++QRRDFL EASIMGQFDHPNIIRLEGVVTK     
Sbjct: 637 SGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTK----- 691

Query: 193 IGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKH 252
                                                 +PVMIV EYMENGSLDSFLRKH
Sbjct: 692 -------------------------------------SKPVMIVTEYMENGSLDSFLRKH 714

Query: 253 DGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD 312
           D  FTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNIL+NSNLVCKVSDFGLSRVLEDD
Sbjct: 715 DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDD 774

Query: 313 PEAAYTT 319
           PEAAYTT
Sbjct: 775 PEAAYTT 781


>gi|4758282 ephrin receptor EphA7 [Homo sapiens]
          Length = 998

 Score =  339 bits (869), Expect = 2e-93
 Identities = 179/307 (58%), Positives = 216/307 (70%), Gaps = 47/307 (15%)

Query: 14  LNEKWDFIASASDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEE 73
           L E    +  A+ +++EQ  +++IA  AV G  +LV +   F+I  R   Y KA  + +E
Sbjct: 535 LEEATGKMFEATAVSSEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDE 594

Query: 74  KRRNHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCS 133
           +   H      +FPG KTYIDP+TYEDP+ AVH+FAKE+D S I+IERVIGAGEFGEVCS
Sbjct: 595 ELYFHF-----KFPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCS 649

Query: 134 GRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAI 193
           GRLK PGKR++ VAIKTLK G+ ++QRRDFL EASIMGQFDHPN++ LEGVVT+      
Sbjct: 650 GRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTR------ 703

Query: 194 GVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHD 253
                                               G+PVMIV+E+MENG+LD+FLRKHD
Sbjct: 704 ------------------------------------GKPVMIVIEFMENGALDAFLRKHD 727

Query: 254 GHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDP 313
           G FTVIQLVGMLRGIA+GM+YL+DMGYVHRDLAARNILVNSNLVCKVSDFGLSRV+EDDP
Sbjct: 728 GQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDP 787

Query: 314 EAAYTTT 320
           EA YTTT
Sbjct: 788 EAVYTTT 794


>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo
           sapiens]
          Length = 1037

 Score =  336 bits (861), Expect = 2e-92
 Identities = 186/314 (59%), Positives = 214/314 (68%), Gaps = 66/314 (21%)

Query: 28  AAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQ-------------------W---YI 65
           +++Q QI VIA +   G  LL ++ +  L++G C                    W   Y 
Sbjct: 566 SSDQSQIPVIAVSVTVGVILLAVV-IGVLLSGSCCECGCGRASSLCAVAHPSLIWRCGYS 624

Query: 66  KAKMKSEEKRRNHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGA 125
           KAK   EE++  H  NGH++ PG++TYIDP TYEDP+ AVHEFAKEI+ S I IERVIGA
Sbjct: 625 KAKQDPEEEKM-HFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGA 683

Query: 126 GEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVV 185
           GEFGEVCSGRLK PGKRE+PVAIKTLK G+ ++QRRDFL EASIMGQFDHPNII LEGVV
Sbjct: 684 GEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVV 743

Query: 186 TKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSL 245
           TK                                           +PVMIV EYMENGSL
Sbjct: 744 TK------------------------------------------SKPVMIVTEYMENGSL 761

Query: 246 DSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGL 305
           D+FL+K+DG FTVIQLVGMLRGI++GMKYLSDMGYVHRDLAARNIL+NSNLVCKVSDFGL
Sbjct: 762 DTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGL 821

Query: 306 SRVLEDDPEAAYTT 319
           SRVLEDDPEAAYTT
Sbjct: 822 SRVLEDDPEAAYTT 835


>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
          Length = 986

 Score =  321 bits (822), Expect = 7e-88
 Identities = 177/284 (62%), Positives = 200/284 (70%), Gaps = 50/284 (17%)

Query: 36  VIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEKRRNHLQNGHLRFPGIKTYIDP 95
           V+  +  G   L+VIL   F+I+ R   Y KAK +++E++  HL  G      ++TY+DP
Sbjct: 548 VLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEK--HLNQG------VRTYVDP 599

Query: 96  DTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGH 155
            TYEDP+ AV EFAKEID S I+IE+VIG GEFGEVCSGRLK PGKREI VAIKTLK G+
Sbjct: 600 FTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGY 659

Query: 156 MDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPH 215
            D+QRRDFL EASIMGQFDHPNII LEGVVTK           C                
Sbjct: 660 TDKQRRDFLSEASIMGQFDHPNIIHLEGVVTK-----------C---------------- 692

Query: 216 PVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYL 275
                          +PVMI+ EYMENGSLD+FLRK+DG FTVIQLVGMLRGI SGMKYL
Sbjct: 693 ---------------KPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYL 737

Query: 276 SDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTT 319
           SDM YVHRDLAARNILVNSNLVCKVSDFG+SRVLEDDPEAAYTT
Sbjct: 738 SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTT 781


>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo
           sapiens]
          Length = 987

 Score =  294 bits (752), Expect = 9e-80
 Identities = 162/290 (55%), Positives = 198/290 (68%), Gaps = 45/290 (15%)

Query: 31  QGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEKRRNHLQNGHLRFPGIK 90
           Q ++ +I  ++  G   L+ + +  ++  R + + +A  +  +K + H  +GH+  PG+K
Sbjct: 538 QEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRRGFERADSEYTDKLQ-HYTSGHMT-PGMK 595

Query: 91  TYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKT 150
            YIDP TYEDP+ AV EFAKEID S ++IE+VIGAGEFGEVCSG LK PGKREI VAIKT
Sbjct: 596 IYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKT 655

Query: 151 LKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNS 210
           LK G+ ++QRRDFL EASIMGQFDHPN+I LEGVVTK +                     
Sbjct: 656 LKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKST--------------------- 694

Query: 211 IQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIAS 270
                                PVMI+ E+MENGSLDSFLR++DG FTVIQLVGMLRGIA+
Sbjct: 695 ---------------------PVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAA 733

Query: 271 GMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD-PEAAYTT 319
           GMKYL+DM YVHRDLAARNILVNSNLVCKVSDFGLSR LEDD  +  YT+
Sbjct: 734 GMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTS 783


>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
           sapiens]
          Length = 986

 Score =  290 bits (743), Expect = 9e-79
 Identities = 162/290 (55%), Positives = 198/290 (68%), Gaps = 46/290 (15%)

Query: 31  QGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEKRRNHLQNGHLRFPGIK 90
           Q ++ +I  ++  G   L+ + +  ++  R + + +A  +  +K + H  +GH+  PG+K
Sbjct: 538 QEKLPLIIGSSAAGLVFLIAVVVIAIVCNR-RGFERADSEYTDKLQ-HYTSGHMT-PGMK 594

Query: 91  TYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKT 150
            YIDP TYEDP+ AV EFAKEID S ++IE+VIGAGEFGEVCSG LK PGKREI VAIKT
Sbjct: 595 IYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKT 654

Query: 151 LKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNS 210
           LK G+ ++QRRDFL EASIMGQFDHPN+I LEGVVTK +                     
Sbjct: 655 LKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKST--------------------- 693

Query: 211 IQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIAS 270
                                PVMI+ E+MENGSLDSFLR++DG FTVIQLVGMLRGIA+
Sbjct: 694 ---------------------PVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAA 732

Query: 271 GMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD-PEAAYTT 319
           GMKYL+DM YVHRDLAARNILVNSNLVCKVSDFGLSR LEDD  +  YT+
Sbjct: 733 GMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTS 782


>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
          Length = 984

 Score =  290 bits (742), Expect = 1e-78
 Identities = 163/289 (56%), Positives = 193/289 (66%), Gaps = 46/289 (15%)

Query: 33  QILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEKRRNHLQNGHLRFPGIKTY 92
           Q+ +IA +A  G   +V L    ++  R + Y K  + S++ +      G    PG+K Y
Sbjct: 538 QLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGS---PGMKIY 594

Query: 93  IDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLK 152
           IDP TYEDP+ AV EFAKEID S ++IE VIGAGEFGEV  GRLK PGKREI VAIKTLK
Sbjct: 595 IDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLK 654

Query: 153 GGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQ 212
            G+ ++QRRDFL EASIMGQFDHPNIIRLEGVVTK                         
Sbjct: 655 AGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTK------------------------- 689

Query: 213 APHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGM 272
                             RPVMI+ E+MENG+LDSFLR++DG FTVIQLVGMLRGIA+GM
Sbjct: 690 -----------------SRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGM 732

Query: 273 KYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD-PEAAYTTT 320
           KYL++M YVHRDLAARNILVNSNLVCKVSDFGLSR L+DD  +  YT++
Sbjct: 733 KYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSS 781


>gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]
          Length = 998

 Score =  285 bits (730), Expect = 3e-77
 Identities = 163/291 (56%), Positives = 194/291 (66%), Gaps = 50/291 (17%)

Query: 31  QGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEKRRNHLQNGHLRFPGIK 90
           Q Q+ +I  +A  G   +V + +  ++  R Q +  +  +  EK + ++       PG+K
Sbjct: 554 QEQLPLIVGSATAGLVFVVAVVVIAIVCLRKQRH-GSDSEYTEKLQQYIA------PGMK 606

Query: 91  TYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKT 150
            YIDP TYEDP+ AV EFAKEID S ++IE VIGAGEFGEVC GRLK PG+RE+ VAIKT
Sbjct: 607 VYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKT 666

Query: 151 LKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNS 210
           LK G+ +RQRRDFL EASIMGQFDHPNIIRLEGVVTK                       
Sbjct: 667 LKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTK----------------------- 703

Query: 211 IQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIAS 270
                               RPVMI+ E+MEN +LDSFLR +DG FTVIQLVGMLRGIA+
Sbjct: 704 -------------------SRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAA 744

Query: 271 GMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDP-EAAYTTT 320
           GMKYLS+M YVHRDLAARNILVNSNLVCKVSDFGLSR LEDDP +  YT++
Sbjct: 745 GMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSS 795


>gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo
           sapiens]
          Length = 1005

 Score =  285 bits (728), Expect = 5e-77
 Identities = 155/288 (53%), Positives = 187/288 (64%), Gaps = 56/288 (19%)

Query: 46  TLLVILTLFFLITGRCQWYIKAKMKSEEKRRNHLQNGHL-------------RFPGIKTY 92
           T LV+L L  +   R   Y KA   S+E++  H QNG               + P  + Y
Sbjct: 552 TGLVVLLLLLICKKRHCGYSKAFQDSDEEKM-HYQNGQAPPPVFLPLHHPPGKLPEPQFY 610

Query: 93  IDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLK 152
            +P TYE+P  A   F +EI+ SRI IE++IG+G+ GEVC GRL+ PG+R++PVAIK LK
Sbjct: 611 AEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALK 670

Query: 153 GGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQ 212
            G+ +RQRRDFL EASIMGQFDHPNIIRLEGVVT+                         
Sbjct: 671 AGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTR------------------------- 705

Query: 213 APHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGM 272
                            GR  MIV EYMENGSLD+FLR HDG FT++QLVGMLRG+ +GM
Sbjct: 706 -----------------GRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGM 748

Query: 273 KYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTT 320
           +YLSD+GYVHRDLAARN+LV+SNLVCKVSDFGLSRVLEDDP+AAYTTT
Sbjct: 749 RYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTT 796


>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
          Length = 987

 Score =  276 bits (706), Expect = 2e-74
 Identities = 158/287 (55%), Positives = 189/287 (65%), Gaps = 50/287 (17%)

Query: 35  LVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEKRRNHLQNGHLRFPGIKTYID 94
           L+  TA VG   +LV++ +  L        ++ +    E   +     +L   G K YID
Sbjct: 540 LIAGTAVVGVVLVLVVIVVAVLC-------LRKQSNGREAEYSDKHGQYLIGHGTKVYID 592

Query: 95  PDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGG 154
           P TYEDP+ AV EFAKEID S ++IE VIGAGEFGEVC GRLK PGK+E  VAIKTLKGG
Sbjct: 593 PFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGG 652

Query: 155 HMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAP 214
           + +RQRR+FL EASIMGQF+HPNIIRLEGVVT                      NS+   
Sbjct: 653 YTERQRREFLSEASIMGQFEHPNIIRLEGVVT----------------------NSM--- 687

Query: 215 HPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKY 274
                            PVMI+ E+MENG+LDSFLR +DG FTVIQLVGMLRGIASGM+Y
Sbjct: 688 -----------------PVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRY 730

Query: 275 LSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD-PEAAYTTT 320
           L++M YVHRDLAARNILVNSNLVCKVSDFGLSR LE++  +  YT++
Sbjct: 731 LAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSS 777


>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
          Length = 976

 Score =  265 bits (678), Expect = 3e-71
 Identities = 150/290 (51%), Positives = 185/290 (63%), Gaps = 48/290 (16%)

Query: 32  GQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEKRRNHLQNGHLRFPGIKT 91
           G + VI   AVG   LLV+  + F I  R     +   ++ +   +   +   +   +KT
Sbjct: 533 GNLAVIGGVAVGVVLLLVLAGVGFFIHRR-----RKNQRARQSPEDVYFSKSEQLKPLKT 587

Query: 92  YIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTP-GKREIPVAIKT 150
           Y+DP TYEDP+ AV +F  EI PS +  ++VIGAGEFGEV  G LKT  GK+E+PVAIKT
Sbjct: 588 YVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKT 647

Query: 151 LKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNS 210
           LK G+ ++QR DFL EA IMGQF H NIIRLEGV++K                       
Sbjct: 648 LKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKY---------------------- 685

Query: 211 IQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIAS 270
                               +P+MI+ EYMENG+LD FLR+ DG F+V+QLVGMLRGIA+
Sbjct: 686 --------------------KPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAA 725

Query: 271 GMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTT 320
           GMKYL++M YVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEA YTT+
Sbjct: 726 GMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTS 775


>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
          Length = 976

 Score =  193 bits (490), Expect = 2e-49
 Identities = 109/231 (47%), Positives = 138/231 (59%), Gaps = 43/231 (18%)

Query: 89  IKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAI 148
           +K Y+D   YEDP+    +F +E+DP+ + ++ VIG GEFGEV  G L+ P +    VAI
Sbjct: 596 LKPYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAI 655

Query: 149 KTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFL 208
           KTLK      Q  +FLREA+IMGQF HP+I+ LEGVVTKR                    
Sbjct: 656 KTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKR-------------------- 695

Query: 209 NSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGI 268
                                 +P+MI+ E+MENG+LD+FLR+ +      QLV ML+GI
Sbjct: 696 ----------------------KPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGI 733

Query: 269 ASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTT 319
           ASGM YLS+  YVHRDLAARNILVN NL CKVSDFGL+R+L DD +  Y T
Sbjct: 734 ASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLL-DDFDGTYET 783


>gi|150456460 EPH receptor A10 isofom 3 [Homo sapiens]
          Length = 1008

 Score =  190 bits (482), Expect = 2e-48
 Identities = 112/299 (37%), Positives = 159/299 (53%), Gaps = 47/299 (15%)

Query: 21  IASASDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEKRRNHLQ 80
           +  A+  + +Q   +V+    +    +L  +     I  R   Y K    + ++   +  
Sbjct: 552 LGEAASGSRDQSPAIVVTVVTISALLVLGSVMSVLAIWRRPCSYGKGGGDAHDEEELYF- 610

Query: 81  NGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPG 140
             H + P  +T++DP +  D   AVH FAKE+D   + +ER +G G FGE+C G L+ PG
Sbjct: 611 --HFKVPTRRTFLDPQSCGDLLQAVHLFAKELDAKSVTLERSLGGGRFGELCCGCLQLPG 668

Query: 141 KREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCP 200
           ++E+ VA+  L+    D QR  FL EA  +GQFDH +I+RLEGVVT+             
Sbjct: 669 RQELLVAVHMLRDSASDSQRLGFLAEALTLGQFDHSHIVRLEGVVTR------------- 715

Query: 201 SFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQ 260
                                        G  +MIV EYM +G+LD FLR+H+G     Q
Sbjct: 716 -----------------------------GSTLMIVTEYMSHGALDGFLRRHEGQLVAGQ 746

Query: 261 LVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTT 319
           L+G+L G+AS MKYLS+MGYVHR LAAR++LV+S+LVCK+S FG  R   D  EA YTT
Sbjct: 747 LMGLLPGLASAMKYLSEMGYVHRGLAARHVLVSSDLVCKISGFG--RGPRDRSEAVYTT 803


>gi|194097332 ephrin receptor EphB6 precursor [Homo sapiens]
          Length = 1021

 Score =  185 bits (470), Expect = 4e-47
 Identities = 99/219 (45%), Positives = 131/219 (59%), Gaps = 42/219 (19%)

Query: 88  GIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVA 147
           G+K YIDP TYEDP  A+ E A+E+DP+ I+IE VIG G FGEV  GRL+  G+RE  VA
Sbjct: 641 GVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVA 700

Query: 148 IKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGF 207
           I+ L  G  +  +  FL  A+++GQF HPNI+RLEGVVTK                    
Sbjct: 701 IQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTK-------------------- 740

Query: 208 LNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRG 267
                                  RP+M++ E+ME G LDSFLR+ +G F+ +QLV M RG
Sbjct: 741 ----------------------SRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRG 778

Query: 268 IASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLS 306
           +A+ M+YLS   +VHR L+A ++LVNS+LVCKV+  G S
Sbjct: 779 VAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHS 817


>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
          Length = 1074

 Score =  111 bits (278), Expect = 8e-25
 Identities = 74/218 (33%), Positives = 103/218 (47%), Gaps = 47/218 (21%)

Query: 94  DPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKG 153
           + DTY  PS   +E  +E    RI + R IG G+FG+V  G   +P    + VAIKT K 
Sbjct: 425 EEDTYTMPSTRDYEIQRE----RIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN 480

Query: 154 GHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQA 213
              D  R  FL+EA  M QFDHP+I++L GV+T+                          
Sbjct: 481 CTSDSVREKFLQEALTMRQFDHPHIVKLIGVITE-------------------------- 514

Query: 214 PHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMK 273
                             PV I++E    G L SFL+       +  L+     +++ + 
Sbjct: 515 -----------------NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALA 557

Query: 274 YLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLED 311
           YL    +VHRD+AARN+LV+SN   K+ DFGLSR +ED
Sbjct: 558 YLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMED 595


>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
          Length = 1052

 Score =  111 bits (278), Expect = 8e-25
 Identities = 74/218 (33%), Positives = 103/218 (47%), Gaps = 47/218 (21%)

Query: 94  DPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKG 153
           + DTY  PS   +E  +E    RI + R IG G+FG+V  G   +P    + VAIKT K 
Sbjct: 403 EEDTYTMPSTRDYEIQRE----RIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN 458

Query: 154 GHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQA 213
              D  R  FL+EA  M QFDHP+I++L GV+T+                          
Sbjct: 459 CTSDSVREKFLQEALTMRQFDHPHIVKLIGVITE-------------------------- 492

Query: 214 PHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMK 273
                             PV I++E    G L SFL+       +  L+     +++ + 
Sbjct: 493 -----------------NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALA 535

Query: 274 YLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLED 311
           YL    +VHRD+AARN+LV+SN   K+ DFGLSR +ED
Sbjct: 536 YLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMED 573


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  110 bits (276), Expect = 1e-24
 Identities = 77/210 (36%), Positives = 100/210 (47%), Gaps = 53/210 (25%)

Query: 111 EIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIM 170
           EID + I++ + +G+G+FGEV  G          PVA+KTLK G MD    DFLREA IM
Sbjct: 228 EIDRNSIQLLKRLGSGQFGEVWEGLWNNT----TPVAVKTLKPGSMDPN--DFLREAQIM 281

Query: 171 GQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAG 230
               HP +I+L  V T                                            
Sbjct: 282 KNLRHPKLIQLYAVCTLED----------------------------------------- 300

Query: 231 RPVMIVVEYMENGSLDSFLRKHDG---HFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAA 287
            P+ I+ E M +GSL  +L+   G   H T  Q V M   +ASGM YL    Y+HRDLAA
Sbjct: 301 -PIYIITELMRHGSLQEYLQNDTGSKIHLT--QQVDMAAQVASGMAYLESRNYIHRDLAA 357

Query: 288 RNILVNSNLVCKVSDFGLSRVLEDDPEAAY 317
           RN+LV  + + KV+DFGL+RV + D E  Y
Sbjct: 358 RNVLVGEHNIYKVADFGLARVFKVDNEDIY 387


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  110 bits (275), Expect = 2e-24
 Identities = 71/213 (33%), Positives = 106/213 (49%), Gaps = 49/213 (23%)

Query: 101 PSLAVHEFAK-EIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQ 159
           P+ A   + K EIDPS +   + IG+G+FG V  G  ++     I VAIK +  G M  +
Sbjct: 254 PATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRS----HIQVAIKAINEGSMSEE 309

Query: 160 RRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPG 219
             DF+ EA +M +  H  +++L GV  +R                               
Sbjct: 310 --DFIEEAKVMMKLSHSKLVQLYGVCIQR------------------------------- 336

Query: 220 GGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMG 279
                      +P+ IV E+MENG L ++LR++ G      L+ + + I  GM+YL   G
Sbjct: 337 -----------KPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNG 385

Query: 280 YVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD 312
           Y+HRDLAARN LV+S  + K+SDFG++R + DD
Sbjct: 386 YIHRDLAARNCLVSSTCIVKISDFGMTRYVLDD 418


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  109 bits (272), Expect = 4e-24
 Identities = 72/213 (33%), Positives = 107/213 (50%), Gaps = 49/213 (23%)

Query: 101 PSLAVHEFAK-EIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQ 159
           P+ A   + K EI+PS +   R +G+G FG V  G+ +   K    VAIK ++ G M  +
Sbjct: 353 PTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYK----VAIKAIREGAMCEE 408

Query: 160 RRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPG 219
             DF+ EA +M +  HP +++L GV T++                               
Sbjct: 409 --DFIEEAKVMMKLTHPKLVQLYGVCTQQ------------------------------- 435

Query: 220 GGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMG 279
                      +P+ IV E+ME G L +FLR+  GHF+   L+ M + +  GM+YL    
Sbjct: 436 -----------KPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNS 484

Query: 280 YVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD 312
           ++HRDLAARN LV+   V KVSDFG++R + DD
Sbjct: 485 FIHRDLAARNCLVSEAGVVKVSDFGMARYVLDD 517


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  108 bits (271), Expect = 5e-24
 Identities = 78/209 (37%), Positives = 101/209 (48%), Gaps = 50/209 (23%)

Query: 109 AKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREAS 168
           A EI    +R+E  +G G FGEV  G      +    VAIKTLK G M  +   FL+EA 
Sbjct: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTMSPEA--FLQEAQ 315

Query: 169 IMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIP 228
           +M +  H  +++L  VV++                                         
Sbjct: 316 VMKKLRHEKLVQLYAVVSEE---------------------------------------- 335

Query: 229 AGRPVMIVVEYMENGSLDSFLRKHDGHFTVI-QLVGMLRGIASGMKYLSDMGYVHRDLAA 287
              P+ IV EYM  GSL  FL+   G +  + QLV M   IASGM Y+  M YVHRDL A
Sbjct: 336 ---PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRA 392

Query: 288 RNILVNSNLVCKVSDFGLSRVLEDDPEAA 316
            NILV  NLVCKV+DFGL+R++ED+   A
Sbjct: 393 ANILVGENLVCKVADFGLARLIEDNEYTA 421


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  108 bits (271), Expect = 5e-24
 Identities = 78/209 (37%), Positives = 101/209 (48%), Gaps = 50/209 (23%)

Query: 109 AKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREAS 168
           A EI    +R+E  +G G FGEV  G      +    VAIKTLK G M  +   FL+EA 
Sbjct: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTMSPEA--FLQEAQ 315

Query: 169 IMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIP 228
           +M +  H  +++L  VV++                                         
Sbjct: 316 VMKKLRHEKLVQLYAVVSEE---------------------------------------- 335

Query: 229 AGRPVMIVVEYMENGSLDSFLRKHDGHFTVI-QLVGMLRGIASGMKYLSDMGYVHRDLAA 287
              P+ IV EYM  GSL  FL+   G +  + QLV M   IASGM Y+  M YVHRDL A
Sbjct: 336 ---PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRA 392

Query: 288 RNILVNSNLVCKVSDFGLSRVLEDDPEAA 316
            NILV  NLVCKV+DFGL+R++ED+   A
Sbjct: 393 ANILVGENLVCKVADFGLARLIEDNEYTA 421


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  108 bits (269), Expect = 9e-24
 Identities = 77/209 (36%), Positives = 101/209 (48%), Gaps = 50/209 (23%)

Query: 109 AKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREAS 168
           A EI    +R+E  +G G FGEV  G      K    VAIKTLK G M  +   FL+EA 
Sbjct: 269 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTK----VAIKTLKPGTMMPEA--FLQEAQ 322

Query: 169 IMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIP 228
           IM +  H  ++ L  VV++                                         
Sbjct: 323 IMKKLRHDKLVPLYAVVSEE---------------------------------------- 342

Query: 229 AGRPVMIVVEYMENGSLDSFLRKHDGHFTVI-QLVGMLRGIASGMKYLSDMGYVHRDLAA 287
              P+ IV E+M  GSL  FL++ DG +  + QLV M   IA GM Y+  M Y+HRDL A
Sbjct: 343 ---PIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRA 399

Query: 288 RNILVNSNLVCKVSDFGLSRVLEDDPEAA 316
            NILV  NLVCK++DFGL+R++ED+   A
Sbjct: 400 ANILVGENLVCKIADFGLARLIEDNEYTA 428


>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  107 bits (266), Expect = 2e-23
 Identities = 70/207 (33%), Positives = 100/207 (48%), Gaps = 50/207 (24%)

Query: 111 EIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIM 170
           E+    +++   +GAG+FGEV  G      K    VA+K+LK G M      FL EA++M
Sbjct: 239 EVPRETLKLVERLGAGQFGEVWMGYYNGHTK----VAVKSLKQGSMSPDA--FLAEANLM 292

Query: 171 GQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAG 230
            Q  H  ++RL  VVT+                                           
Sbjct: 293 KQLQHQRLVRLYAVVTQE------------------------------------------ 310

Query: 231 RPVMIVVEYMENGSLDSFLRKHDG-HFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARN 289
            P+ I+ EYMENGSL  FL+   G   T+ +L+ M   IA GM ++ +  Y+HRDL A N
Sbjct: 311 -PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAAN 369

Query: 290 ILVNSNLVCKVSDFGLSRVLEDDPEAA 316
           ILV+  L CK++DFGL+R++ED+   A
Sbjct: 370 ILVSDTLSCKIADFGLARLIEDNEYTA 396


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  107 bits (266), Expect = 2e-23
 Identities = 70/207 (33%), Positives = 100/207 (48%), Gaps = 50/207 (24%)

Query: 111 EIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIM 170
           E+    +++   +GAG+FGEV  G      K    VA+K+LK G M      FL EA++M
Sbjct: 239 EVPRETLKLVERLGAGQFGEVWMGYYNGHTK----VAVKSLKQGSMSPDA--FLAEANLM 292

Query: 171 GQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAG 230
            Q  H  ++RL  VVT+                                           
Sbjct: 293 KQLQHQRLVRLYAVVTQE------------------------------------------ 310

Query: 231 RPVMIVVEYMENGSLDSFLRKHDG-HFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARN 289
            P+ I+ EYMENGSL  FL+   G   T+ +L+ M   IA GM ++ +  Y+HRDL A N
Sbjct: 311 -PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAAN 369

Query: 290 ILVNSNLVCKVSDFGLSRVLEDDPEAA 316
           ILV+  L CK++DFGL+R++ED+   A
Sbjct: 370 ILVSDTLSCKIADFGLARLIEDNEYTA 396


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  107 bits (266), Expect = 2e-23
 Identities = 71/209 (33%), Positives = 101/209 (48%), Gaps = 49/209 (23%)

Query: 109 AKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREAS 168
           A EI    I++ + +GAG+FGEV  G      K    VA+KTLK G M  Q   FL EA+
Sbjct: 218 AWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTK----VAVKTLKPGTMSVQA--FLEEAN 271

Query: 169 IMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIP 228
           +M    H  ++RL  VVT+                                         
Sbjct: 272 LMKTLQHDKLVRLYAVVTREE--------------------------------------- 292

Query: 229 AGRPVMIVVEYMENGSLDSFLRKHDGHFTVI-QLVGMLRGIASGMKYLSDMGYVHRDLAA 287
              P+ I+ EYM  GSL  FL+  +G   ++ +L+     IA GM Y+    Y+HRDL A
Sbjct: 293 ---PIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRA 349

Query: 288 RNILVNSNLVCKVSDFGLSRVLEDDPEAA 316
            N+LV+ +L+CK++DFGL+RV+ED+   A
Sbjct: 350 ANVLVSESLMCKIADFGLARVIEDNEYTA 378


>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score =  107 bits (266), Expect = 2e-23
 Identities = 71/209 (33%), Positives = 101/209 (48%), Gaps = 49/209 (23%)

Query: 109 AKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREAS 168
           A EI    I++ + +GAG+FGEV  G      K    VA+KTLK G M  Q   FL EA+
Sbjct: 239 AWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTK----VAVKTLKPGTMSVQA--FLEEAN 292

Query: 169 IMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIP 228
           +M    H  ++RL  VVT+                                         
Sbjct: 293 LMKTLQHDKLVRLYAVVTREE--------------------------------------- 313

Query: 229 AGRPVMIVVEYMENGSLDSFLRKHDGHFTVI-QLVGMLRGIASGMKYLSDMGYVHRDLAA 287
              P+ I+ EYM  GSL  FL+  +G   ++ +L+     IA GM Y+    Y+HRDL A
Sbjct: 314 ---PIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRA 370

Query: 288 RNILVNSNLVCKVSDFGLSRVLEDDPEAA 316
            N+LV+ +L+CK++DFGL+RV+ED+   A
Sbjct: 371 ANVLVSESLMCKIADFGLARVIEDNEYTA 399


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  107 bits (266), Expect = 2e-23
 Identities = 70/209 (33%), Positives = 99/209 (47%), Gaps = 48/209 (22%)

Query: 112 IDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMG 171
           IDPS +   + IG+G+FG V  G      K    VAIKT++ G M  +  DF+ EA +M 
Sbjct: 358 IDPSELTFVQEIGSGQFGLVHLGYWLNKDK----VAIKTIREGAMSEE--DFIEEAEVMM 411

Query: 172 QFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGR 231
           +  HP +++L GV  +++                                          
Sbjct: 412 KLSHPKLVQLYGVCLEQA------------------------------------------ 429

Query: 232 PVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNIL 291
           P+ +V E+ME+G L  +LR   G F    L+GM   +  GM YL +   +HRDLAARN L
Sbjct: 430 PICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCL 489

Query: 292 VNSNLVCKVSDFGLSRVLEDDPEAAYTTT 320
           V  N V KVSDFG++R + DD   + T T
Sbjct: 490 VGENQVIKVSDFGMTRFVLDDQYTSSTGT 518


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.140    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,859,655
Number of Sequences: 37866
Number of extensions: 601618
Number of successful extensions: 3087
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 593
Number of HSP's successfully gapped in prelim test: 124
Number of HSP's that attempted gapping in prelim test: 1784
Number of HSP's gapped (non-prelim): 1206
length of query: 334
length of database: 18,247,518
effective HSP length: 103
effective length of query: 231
effective length of database: 14,347,320
effective search space: 3314230920
effective search space used: 3314230920
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.