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Search of human proteins with 26787962
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|26787962 advanced glycosylation end product-specific
receptor isoform 2 precursor [Homo sapiens]
(342 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|26787962 advanced glycosylation end product-specific receptor... 714 0.0
gi|10835203 advanced glycosylation end product-specific receptor... 530 e-151
gi|68163411 activated leukocyte cell adhesion molecule [Homo sap... 79 8e-15
gi|71274107 melanoma cell adhesion molecule [Homo sapiens] 69 6e-12
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 67 2e-11
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 67 2e-11
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 67 2e-11
gi|224994173 roundabout 1 isoform d [Homo sapiens] 64 2e-10
gi|224994171 roundabout 1 isoform c [Homo sapiens] 64 2e-10
gi|19743806 roundabout 1 isoform b [Homo sapiens] 64 2e-10
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 64 2e-10
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 64 2e-10
gi|4506569 roundabout 1 isoform a [Homo sapiens] 64 2e-10
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 62 1e-09
gi|24111244 MAM domain containing glycosylphosphatidylinositol a... 58 1e-08
gi|118572606 hemicentin 1 [Homo sapiens] 56 4e-08
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 56 4e-08
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 56 4e-08
gi|109150416 peroxidasin [Homo sapiens] 54 2e-07
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 54 2e-07
gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens] 52 8e-07
gi|221316762 neurotrimin isoform 4 [Homo sapiens] 51 2e-06
gi|221316757 neurotrimin isoform 3 [Homo sapiens] 51 2e-06
gi|115298665 neurotrimin isoform 2 [Homo sapiens] 51 2e-06
gi|7705413 neurotrimin isoform 1 [Homo sapiens] 51 2e-06
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 50 2e-06
gi|61742797 basal cell adhesion molecule isoform 2 precursor [Ho... 50 3e-06
gi|31543106 basal cell adhesion molecule isoform 1 precursor [Ho... 50 3e-06
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 50 3e-06
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ... 49 7e-06
>gi|26787962 advanced glycosylation end product-specific receptor
isoform 2 precursor [Homo sapiens]
Length = 342
Score = 714 bits (1844), Expect = 0.0
Identities = 342/342 (100%), Positives = 342/342 (100%)
Query: 1 MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDS 60
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDS
Sbjct: 1 MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDS 60
Query: 61 VARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELT 120
VARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELT
Sbjct: 61 VARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELT 120
Query: 121 AGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMV 180
AGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMV
Sbjct: 121 AGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMV 180
Query: 181 TPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGT 240
TPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGT
Sbjct: 181 TPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGT 240
Query: 241 VTLTCEVPAQPSPQIHWMKDVSDLERGAGRTRRGGANCRLCGRIRAGNSSPGPGDPGRPG 300
VTLTCEVPAQPSPQIHWMKDVSDLERGAGRTRRGGANCRLCGRIRAGNSSPGPGDPGRPG
Sbjct: 241 VTLTCEVPAQPSPQIHWMKDVSDLERGAGRTRRGGANCRLCGRIRAGNSSPGPGDPGRPG 300
Query: 301 DSRPAHWGHLVAKAATPRRGEEGPRKPGGRGGACRTESVGGT 342
DSRPAHWGHLVAKAATPRRGEEGPRKPGGRGGACRTESVGGT
Sbjct: 301 DSRPAHWGHLVAKAATPRRGEEGPRKPGGRGGACRTESVGGT 342
>gi|10835203 advanced glycosylation end product-specific receptor
isoform 1 precursor [Homo sapiens]
Length = 404
Score = 530 bits (1365), Expect = e-151
Identities = 260/274 (94%), Positives = 260/274 (94%), Gaps = 14/274 (5%)
Query: 1 MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKL------- 53
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKL
Sbjct: 1 MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA 60
Query: 54 -------GGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI 106
GGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI
Sbjct: 61 WKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI 120
Query: 107 PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH 166
PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH
Sbjct: 121 PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH 180
Query: 167 PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL 226
PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL
Sbjct: 181 PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL 240
Query: 227 VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD
Sbjct: 241 VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 274
Score = 32.3 bits (72), Expect = 0.63
Identities = 18/57 (31%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQA 87
G + L C+ P +P ++ W G P + P+ L LP +G QD+G + C A
Sbjct: 252 GGTVTLTCE-VPAQPSPQIHWMKDGVPLP----LPPSPVLILPEIGPQDQGTYSCVA 303
>gi|68163411 activated leukocyte cell adhesion molecule [Homo
sapiens]
Length = 583
Score = 78.6 bits (192), Expect = 8e-15
Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 5/189 (2%)
Query: 67 NGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNK 126
N +L + I DE F C + + V+V++ P KPEIV A L K
Sbjct: 95 NYTLSISNARISDEKRFVCMLVTEDNVFEAPTI-VKVFKQPSKPEIVSKALFLETEQLKK 153
Query: 127 VGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGG 186
+G C+SE SYP G ++W+ +GK L P E V + + P T L+T+ S L +
Sbjct: 154 LGDCISEDSYPDGNITWYRNGKVLHPLEGAVVIIFKKEMDPVTQLYTMTSTLEYKTTK-A 212
Query: 187 DPRPTFSCSFSPGLPRHRALRTAPIQPRVWE-PVPLEEVQLVVEPEGGAVAPGGTVTLTC 245
D + F+CS + P + +T + V++ P E+V + V P A+ G +TL C
Sbjct: 213 DIQMPFTCSVTYYGPSGQ--KTIHSEQAVFDIYYPTEQVTIQVLPPKNAIKEGDNITLKC 270
Query: 246 EVPAQPSPQ 254
P P+
Sbjct: 271 LGNGNPPPE 279
>gi|71274107 melanoma cell adhesion molecule [Homo sapiens]
Length = 646
Score = 68.9 bits (167), Expect = 6e-12
Identities = 57/189 (30%), Positives = 87/189 (46%), Gaps = 12/189 (6%)
Query: 69 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDS--ASELTAGVPNK 126
+L L V QDE IF CQ +E + ++RVY+ P +P I + + + P +
Sbjct: 100 TLALTQVTPQDERIFLCQGKRPRSQEYR--IQLRVYKAPEEPNIQVNPLGIPVNSKEPEE 157
Query: 127 VGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGG 186
V TCV YP + W+ +G+PL + V + + ++ +GL+TLQS L +
Sbjct: 158 VATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHI-QSSQTVESSGLYTLQSILKAQLVK-E 215
Query: 187 DPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPV--PLEEVQLVVEPEGGAVAPGGTVTLT 244
D F C + LP ++ + V PV P E+V L VEP G + G V +
Sbjct: 216 DKDAQFYCELNYRLPSGNHMKES---REVTVPVFYPTEKVWLEVEPV-GMLKEGDRVEIR 271
Query: 245 CEVPAQPSP 253
C P P
Sbjct: 272 CLADGNPPP 280
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 67.0 bits (162), Expect = 2e-11
Identities = 82/276 (29%), Positives = 114/276 (41%), Gaps = 47/276 (17%)
Query: 25 NITARIGEPLVLKCK--GAPK------KPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVG 76
N+T P +L C+ G+PK K Q+L+++L G + R+LP+ +L L A G
Sbjct: 2581 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAY----RLLPSNALLLTAPG 2636
Query: 77 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TCVSEGS 135
QD F C N G E Y+V V+ +P P I D ++ T + V TC S G
Sbjct: 2637 PQDSAQFECVVSNEVG-EAHRLYQVTVH-VP--PTIADDQTDFTVTMMAPVVLTCHSTG- 2691
Query: 136 YPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCS 195
PA T+SW G L G V +G + L P G R T S
Sbjct: 2692 IPAPTVSWSKAGAQLGARGSGYRVS-------PSGALEIGQAL---PIHAG--RYTCSAR 2739
Query: 196 FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 255
S G+ T P V +P+P V+ V E E V L CE P P I
Sbjct: 2740 NSAGVAHKHVFLTVQASP-VVKPLP-SVVRAVAEEE---------VLLPCEASGIPRPTI 2788
Query: 256 HWMKDVSDLERGAGRTRRGGANCRLCGRIRAGNSSP 291
W K+ ++ G G G++R ++SP
Sbjct: 2789 TWQKEGLNVATGVSTQVLPG------GQLRIAHASP 2818
Score = 60.1 bits (144), Expect = 3e-09
Identities = 64/256 (25%), Positives = 105/256 (41%), Gaps = 35/256 (13%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGS---LFLPAVGIQ 78
G+ + +R GE + + C PP + W G P R L +GS L + V +
Sbjct: 2128 GSGTLVSRPGELVTMVCP-VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLA 2186
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 138
D GIF C A + G + N+ ++V Q+P E V+ +++ + V P
Sbjct: 2187 DAGIFTCVAASPAGVADR-NFTLQV-QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 2244
Query: 139 GTLSWHLDGKPLVPN--EKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 196
+SW DG+PL+ E+G S++ + ++G ++ V + G+ R F
Sbjct: 2245 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSC-----VAVSEAGEARRHF---- 2295
Query: 197 SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIH 256
Q V EP +E+ +P ++ PG + L C+ P P I
Sbjct: 2296 ---------------QLTVMEPPHIEDSG---QPTELSLTPGAPMELLCDAQGTPQPNIT 2337
Query: 257 WMKDVSDLERGAGRTR 272
W KD L R +R
Sbjct: 2338 WHKDGQALTRLENNSR 2353
Score = 55.1 bits (131), Expect = 9e-08
Identities = 68/246 (27%), Positives = 104/246 (42%), Gaps = 48/246 (19%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNG-SLFLPAVGIQDEGIFRCQAMN 89
G + L C+ A P + W G P +++ L G SL L AVG D G + C A++
Sbjct: 2230 GSLVELPCE-ARGVPLPLVSWMKDGEPL--LSQSLEQGPSLQLEAVGAGDSGTYSCVAVS 2286
Query: 90 RNGKETKSNYRVRVYQIPGKPEIVDSAS----ELTAGVPNKVGTCVSEGSYPAGTLSWHL 145
G E + ++++ V + P I DS LT G P ++ C ++G+ P ++WH
Sbjct: 2287 EAG-EARRHFQLTVME---PPHIEDSGQPTELSLTPGAPMEL-LCDAQGT-PQPNITWHK 2340
Query: 146 DGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRA 205
DG+ L E S + R + GL+T +E SP ++
Sbjct: 2341 DGQALTRLENN-SRATRVLRVRDAGLYTCLAE-------------------SPAGAIEKS 2380
Query: 206 LRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPG---GTVTLTCEVPAQPSPQIHWMKDVS 262
R RV P +V P G G G + L C V A+P+P+I W +D
Sbjct: 2381 FRV-----RVQAPPN------IVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGI 2429
Query: 263 DLERGA 268
L+ A
Sbjct: 2430 VLQEDA 2435
Score = 52.4 bits (124), Expect = 6e-07
Identities = 63/243 (25%), Positives = 95/243 (39%), Gaps = 44/243 (18%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWDS-----VARVLPNGSLFLPAVGIQDEGIFRC 85
G+ + L C+ A +PP + W G P + L GSL L + D G + C
Sbjct: 2041 GQEVRLDCE-ADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2099
Query: 86 QAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT--CVSEGSYPAGTLSW 143
A N G++ + + V V P + D + L + P ++ T C GS P +SW
Sbjct: 2100 VAHNPAGEDARL-HTVNVLVPPTIKQGADGSGTLVSR-PGELVTMVCPVRGSPPI-HVSW 2156
Query: 144 HLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFS 197
DG PL +++ G +++ + + G+FT + +PA D T
Sbjct: 2157 LKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC---VAASPAGVADRNFTLQVQVP 2213
Query: 198 PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHW 257
P V EPV + +VV G V L CE P P + W
Sbjct: 2214 P----------------VLEPVEFQNDVVVVR--------GSLVELPCEARGVPLPLVSW 2249
Query: 258 MKD 260
MKD
Sbjct: 2250 MKD 2252
Score = 52.0 bits (123), Expect = 8e-07
Identities = 58/253 (22%), Positives = 96/253 (37%), Gaps = 24/253 (9%)
Query: 11 VLVLSLWGAVVGAQ-NITARIGEPLVLKCKGAPKKPPQRLEWKLGGG--PWDSVARVLPN 67
VL + + +++G + N++ E + L+C+ PP WK G P V
Sbjct: 873 VLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADK 932
Query: 68 GSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKV 127
L + + D G + C+A+N+ G+ K +Y + V+ P P + G P +
Sbjct: 933 ALLQVDRADVWDAGHYTCEALNQAGRSEK-HYNLNVWVAPVFPLRESHTLTVREGHPTSL 991
Query: 128 GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 187
+C G P +SW DG+PL G+ R L+ Q++L +
Sbjct: 992 -SCECRG-VPFPKISWRKDGQPLPGEGAGLQHVSAVGRL----LYLGQAQL------AQE 1039
Query: 188 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 247
T CS G + P++ P P +V G TL C
Sbjct: 1040 GTYTCECSNVVGNSSQDLQLEVHVPPQIAGPRE--------PPTQVSVVQDGVATLECNA 1091
Query: 248 PAQPSPQIHWMKD 260
+P P + W +D
Sbjct: 1092 TGKPPPTVTWERD 1104
Score = 50.1 bits (118), Expect = 3e-06
Identities = 65/251 (25%), Positives = 91/251 (36%), Gaps = 38/251 (15%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVG-------- 76
NITA + PL L C+ A PP + W G P V P +L A G
Sbjct: 1170 NITAALHSPLTLLCE-AMGIPPPAIRWFRGEEP------VSPGEDTYLLAGGWMLKMTQT 1222
Query: 77 -IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGS 135
QD G++ C A N G E + N+ V V +P E D + +
Sbjct: 1223 QEQDSGLYSCLASNEAG-EARRNFSVEVL-VPPSIENEDLEEVIKVLDGQTAHLMCNVTG 1280
Query: 136 YPAGTLSWHLDGKPLVPNE-KGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSC 194
+P L+W DG+PL + +S + + L + + G+ F
Sbjct: 1281 HPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQL 1340
Query: 195 SFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQ 254
S + AP E EEV + V ++L CE A PSP
Sbjct: 1341 S----------VLLAPTILGGAEDSADEEVTVTV---------NNPISLICEALAFPSPN 1381
Query: 255 IHWMKDVSDLE 265
I WMKD + E
Sbjct: 1382 ITWMKDGAPFE 1392
Score = 50.1 bits (118), Expect = 3e-06
Identities = 66/265 (24%), Positives = 110/265 (41%), Gaps = 37/265 (13%)
Query: 2 AAGTAVGAWVLVLSLWGAVV-GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDS 60
+AG+A+G LV+ + + G +++ G L CK A P + W G P
Sbjct: 2831 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCK-ARGSPEPNITWDKDGQPVSG 2889
Query: 61 VA---RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSAS 117
+ P+G L + + QD G + C A N G+ + RV + I P
Sbjct: 2890 AEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR---RVHL-TILVLPVFTTLPG 2945
Query: 118 ELTAGVPNKVGT-CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQS 176
+ + + +++ C + GS P + W ++ +P+ +GVS ++ G TLQ
Sbjct: 2946 DRSLRLGDRLWLRCAARGS-PTPRIGWTVNDRPVT---EGVSEQD--------GGSTLQR 2993
Query: 177 ELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEV-QLVVEPEGGAV 235
+ G T+ C + R +A+ ++ PV E +VEP GG++
Sbjct: 2994 AAVSREDSG-----TYVCWAENRVGRTQAVSFVHVKEA---PVLQGEAFSYLVEPVGGSI 3045
Query: 236 APGGTVTLTCEVPAQPSPQIHWMKD 260
L C V P P IHW+KD
Sbjct: 3046 Q------LDCVVRGDPVPDIHWIKD 3064
Score = 49.7 bits (117), Expect = 4e-06
Identities = 66/287 (22%), Positives = 112/287 (39%), Gaps = 44/287 (15%)
Query: 3 AGTAVGAWVLVLSLWGAVVGA--QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDS 60
AG+A + L + + + G + +TA + + L C P+ +K DS
Sbjct: 1731 AGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK------DS 1784
Query: 61 VARVLPNGSLFLPAVG--------IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEI 112
A L LP + D G++ C+A+N G++ K ++ V P +
Sbjct: 1785 QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL-VQLSVLVPPAFRQA 1843
Query: 113 VDSASE-LTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGL 171
+ + V +K + P T++W+ DG+PLV ++ +++ R
Sbjct: 1844 PRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR------- 1896
Query: 172 FTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQ-PRVWEPVPLEEVQLVVEP 230
L + A+ D + +SC S T +Q P +E E V V
Sbjct: 1897 ------LEIQEAQVSD-KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVA-- 1947
Query: 231 EGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERGA--GRTRRGG 275
G + LTC+V P+P + W+KD +E A G RGG
Sbjct: 1948 -------GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG 1987
Score = 49.3 bits (116), Expect = 5e-06
Identities = 61/251 (24%), Positives = 103/251 (41%), Gaps = 33/251 (13%)
Query: 11 VLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGP-WDSVARVLPNGS 69
+LVL ++ + G +++ R+G+ L L+C A P R+ W + P + V+ +
Sbjct: 2934 ILVLPVFTTLPGDRSL--RLGDRLWLRC-AARGSPTPRIGWTVNDRPVTEGVSEQDGGST 2990
Query: 70 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT 129
L AV +D G + C A NR G+ ++ V V + P ++ S L V +
Sbjct: 2991 LQRAAVSREDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQG--EAFSYLVEPVGGSIQL 3047
Query: 130 -CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDP 188
CV G P + W DG PL +G ++ Q LQ+ + D
Sbjct: 3048 DCVVRGD-PVPDIHWIKDGLPL----RGSHLRHQ-----------LQNGSLTIHRTERDD 3091
Query: 189 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 248
+ C L + + V + P+ +V EP+ V G V L C+
Sbjct: 3092 AGRYQC-----LAENEMGVAKKVVILVLQSAPVFQV----EPQDMTVRSGDDVALRCQAT 3142
Query: 249 AQPSPQIHWMK 259
+P+P I W++
Sbjct: 3143 GEPTPTIEWLQ 3153
Score = 47.4 bits (111), Expect = 2e-05
Identities = 54/199 (27%), Positives = 84/199 (42%), Gaps = 38/199 (19%)
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIP------GKPEIVDSASELTAGVPNKVGTCVS 132
D G++ C+A N G K+ R+ VY P G+P +V + AG P + CV+
Sbjct: 376 DAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAV----AGRPVAL-ECVA 429
Query: 133 EGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTF 192
G +P+ TLSWH +G P V+ ++R + + L+S G +
Sbjct: 430 RG-HPSPTLSWHHEGLP-------VAESNESRLETDGSVLRLESP-------GEASSGLY 474
Query: 193 SCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP--GGTVTLTCEVPAQ 250
SC S P A+ ++ +V QL+V G V G + L C+
Sbjct: 475 SCVASS--PAGEAVLQYSVEVQV-------PPQLLVAEGLGQVTTIVGQPLELPCQASGS 525
Query: 251 PSPQIHWMKDVSDLERGAG 269
P P I W+++ E AG
Sbjct: 526 PVPTIQWLQNGRPAEELAG 544
Score = 47.4 bits (111), Expect = 2e-05
Identities = 68/237 (28%), Positives = 94/237 (39%), Gaps = 38/237 (16%)
Query: 32 EPLVLKCKGAPKKPPQRLEWKLGGGPWDS-----VARVLPNGSLFLPAVGIQDEGIFRCQ 86
+P V + GA KPP W G W VA LP L + V ++DEGI+ C
Sbjct: 617 DPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPP-PLQIEKVDLRDEGIYTCA 675
Query: 87 AMNRNGKETKSNYRVRVYQIPG-KPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHL 145
A N G E+K ++V P +P V+ A A V + C++ G P +SW
Sbjct: 676 ATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLE---CLASG-VPPPDVSWFK 730
Query: 146 DGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFS--PGLPRH 203
+P V + GV+V R L + A+ D ++ C S G
Sbjct: 731 GHQP-VSSWMGVTVSVDGR------------VLRIEQAQLSDAG-SYRCVASNVAGSTEL 776
Query: 204 RALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
R + PR+ P L LV P V LTC PSP + W+KD
Sbjct: 777 RYGLRVNVPPRITLPPSLPGPVLVNTP----------VRLTCNATGAPSPTLMWLKD 823
Score = 47.0 bits (110), Expect = 2e-05
Identities = 57/252 (22%), Positives = 97/252 (38%), Gaps = 33/252 (13%)
Query: 45 PPQRLEWKLGGGPW---DSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRV 101
PP L W P D V+ + L +P V ++ G + C+A N G++ +Y +
Sbjct: 1587 PPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWL-HYEL 1645
Query: 102 RVYQIP---GKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVS 158
V P G E + E+T + V P T+SW +G P P+ +
Sbjct: 1646 LVLTPPVILGDTE--ELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQV 1703
Query: 159 VKE-QTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWE 217
+++ Q + + S + V + G F+ + PR+
Sbjct: 1704 LEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ-------------VPPRI-A 1749
Query: 218 PVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERGAGRTRRGGAN 277
+ LE+V ++ +V+L C+V A P+P++ W KD L G G +
Sbjct: 1750 GLDLEQVTAILN---------SSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH 1800
Query: 278 CRLCGRIRAGNS 289
GR R +S
Sbjct: 1801 TLQLGRARLSDS 1812
Score = 46.2 bits (108), Expect = 4e-05
Identities = 61/230 (26%), Positives = 92/230 (40%), Gaps = 31/230 (13%)
Query: 45 PPQRLEWKLGGGP---WDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRV 101
PP + W G P W V + L + + D G +RC A N G T+ Y +
Sbjct: 722 PPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS-TELRYGL 780
Query: 102 RVYQIPGKPEIVDSA-SELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVP-NEKGVSV 159
RV +P + + S + P ++ TC + G+ P+ TL W DG P+ P G+ V
Sbjct: 781 RV-NVPPRITLPPSLPGPVLVNTPVRL-TCNATGA-PSPTLMWLKDGNPVSPAGTPGLQV 837
Query: 160 KEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPV 219
P + TL S AR D +SC + R + +Q + +
Sbjct: 838 ------FPGGRVLTLAS------ARASDSG-RYSCVAVSAVGEDR--QDVVLQVHMPPSI 882
Query: 220 PLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERGAG 269
EE+ + +V +V L C+ A P P + W KD LE G
Sbjct: 883 LGEELNV-------SVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPG 925
Score = 45.8 bits (107), Expect = 6e-05
Identities = 31/93 (33%), Positives = 48/93 (51%), Gaps = 7/93 (7%)
Query: 21 VGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARV--LPNGSLFLPAVGIQ 78
V Q++T R G+ + L+C+ A +P +EW G P + R+ LP+GSL+L V
Sbjct: 3122 VEPQDMTVRSGDDVALRCQ-ATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG 3180
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPE 111
D G + C A N G T + V + G+P+
Sbjct: 3181 DAGTYDCVAHNLLGSATARAFLV----VRGEPQ 3209
Score = 45.4 bits (106), Expect = 7e-05
Identities = 63/251 (25%), Positives = 98/251 (39%), Gaps = 36/251 (14%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARV--LPNGS-LFLPAVGIQDEGI 82
+ R+G+ VL C+ P + W G P R L G L + + D+G+
Sbjct: 1851 VLVRVGDKAVLSCE-TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGL 1909
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNK--VGTCVSEGSYPAGT 140
+ C+ N G+ ++ + + V Q+P P + +E + V V TC G PA T
Sbjct: 1910 YSCKVSNVAGEAVRT-FTLTV-QVP--PTFENPKTETVSQVAGSPLVLTCDVSG-VPAPT 1964
Query: 141 LSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSC--SFSP 198
++W D P+ + +V R L LQ PA+ G T++C +
Sbjct: 1965 VTWLKDRMPV----ESSAVHGVVSRGGRLQLSRLQ------PAQAG----TYTCVAENTQ 2010
Query: 199 GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 258
R + + PR+ E V G V L CE QP P + W+
Sbjct: 2011 AEARKDFVVAVLVAPRIRSSGVAREHH---------VLEGQEVRLDCEADGQPPPDVAWL 2061
Query: 259 KDVSDLERGAG 269
KD S L + G
Sbjct: 2062 KDGSPLGQDMG 2072
Score = 45.4 bits (106), Expect = 7e-05
Identities = 65/256 (25%), Positives = 99/256 (38%), Gaps = 38/256 (14%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVA---RVLPNGSLFLPAVGIQ 78
G + + + +L C+ A P + W+ P D + +LP GSL + V Q
Sbjct: 2487 GPPAVNVSVNQTALLPCQ-ADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQ 2545
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE--LTAGVPNKVGTCVSEGSY 136
D G + C A N G + + R ++ P I S S LTA P + C + GS
Sbjct: 2546 DAGHYLCLASNSAGSDRQG----RDLRVLEPPAIAPSPSNLTLTAHTPALL-PCEASGS- 2599
Query: 137 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 196
P + W DG+ L R + L S ++ A G F C
Sbjct: 2600 PKPLVVWWKDGQKL------------DFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVV 2647
Query: 197 SPGL-PRHRALR-TAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQ 254
S + HR + T + P + + ++ V +AP V LTC P+P
Sbjct: 2648 SNEVGEAHRLYQVTVHVPPTIAD----DQTDFTVT----MMAP---VVLTCHSTGIPAPT 2696
Query: 255 IHWMKDVSDL-ERGAG 269
+ W K + L RG+G
Sbjct: 2697 VSWSKAGAQLGARGSG 2712
Score = 45.1 bits (105), Expect = 9e-05
Identities = 56/241 (23%), Positives = 89/241 (36%), Gaps = 38/241 (15%)
Query: 36 LKCKGAPKKPPQRLEWKLGGGPWDS-VARVLPNG--SLFLPAVGIQDEGIFRCQAMNRNG 92
L+C A KPP + W+ G P + + L N SL + G + C A N G
Sbjct: 1087 LECN-ATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG 1145
Query: 93 KETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVP 152
+ + + + V P +D + +TA + + + P + W +P+ P
Sbjct: 1146 RAERK-FELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 1204
Query: 153 NEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRAL 206
E G +K + ++GL++ + G+ R FS
Sbjct: 1205 GEDTYLLAGGWMLKMTQTQEQDSGLYSC-----LASNEAGEARRNFSVEV---------- 1249
Query: 207 RTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLER 266
+ P E LEEV V++ G T L C V P P++ W KD L R
Sbjct: 1250 ----LVPPSIENEDLEEVIKVLD--------GQTAHLMCNVTGHPQPKLTWFKDGRPLAR 1297
Query: 267 G 267
G
Sbjct: 1298 G 1298
Score = 43.1 bits (100), Expect = 4e-04
Identities = 58/264 (21%), Positives = 102/264 (38%), Gaps = 38/264 (14%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARV-LPNGSLFLPAVGIQ--DE 80
+ +T + P+ L C+ A P + W G P+++ + L G+ L + Q D
Sbjct: 1358 EEVTVTVNNPISLICE-ALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDA 1416
Query: 81 GIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASEL-TAGVPNKVGTCVS----EGS 135
G + C N G+ K NY V V IP D E+ V KV + ++ +
Sbjct: 1417 GQYTCVVTNELGEAVK-NYHVEVL-IPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWA 1474
Query: 136 YPAGTLSWHLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPR 189
P T+ W+ DG+P+ P+ + G ++ Q + ++G + L V G+
Sbjct: 1475 VPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY-----LCVATNVAGEDD 1529
Query: 190 PTFSCSFSPGLPRHRALRTAPIQPRVWE-PVPLEEVQLVVEPEGGA-----VAPGGTVTL 243
F+ ++ P+ +V + E + E GG + L
Sbjct: 1530 QDFNV----------LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYL 1579
Query: 244 TCEVPAQPSPQIHWMKDVSDLERG 267
C+ A P P + W ++ L G
Sbjct: 1580 YCDTNAIPPPDLTWYREDQPLSAG 1603
Score = 39.3 bits (90), Expect = 0.005
Identities = 62/263 (23%), Positives = 100/263 (38%), Gaps = 47/263 (17%)
Query: 21 VGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR--VLPNGSLF-LPAVGI 77
VG + + ++ L L+C+ + PP + W G P +R VL G L + +
Sbjct: 1453 VGVKEVKTKVNSTLTLECE-SWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQV 1511
Query: 78 QDEGIFRCQAMNRNGKETKS-NYRVRVYQIPGKP-------EIVDSASELTAGVP----- 124
D G + C A N G++ + N ++V + K EI+ E GV
Sbjct: 1512 SDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREI 1571
Query: 125 ---NKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 181
N + P L+W+ + +PL ++ VSV + R LQ L+
Sbjct: 1572 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE-VSVLQGGR--------VLQIPLVRA 1622
Query: 182 PARGGDPRPTFSCSFSPGLP----RHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP 237
G +SC S + + L P PV L + + +VE V
Sbjct: 1623 ENAG-----RYSCKASNEVGEDWLHYELLVLTP-------PVILGDTEELVEEV--TVNA 1668
Query: 238 GGTVTLTCEVPAQPSPQIHWMKD 260
TV+L C P P I W+++
Sbjct: 1669 SSTVSLQCPALGNPVPTISWLQN 1691
Score = 39.3 bits (90), Expect = 0.005
Identities = 52/200 (26%), Positives = 80/200 (40%), Gaps = 37/200 (18%)
Query: 63 RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASEL-TA 121
+VLP G L + +D G + C A N G V Q+P P I + +L T
Sbjct: 2804 QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTR--LVVQVP--PVIENGLPDLSTT 2859
Query: 122 GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQ--SELM 179
+ C + GS P ++W DG+P+ E G FT+Q EL+
Sbjct: 2860 EGSHAFLPCKARGS-PEPNITWDKDGQPVSGAE---------------GKFTIQPSGELL 2903
Query: 180 VTPARGGDPRPTFSCSF--SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP 237
V G D T++C+ + G R R T + P V+ +P + ++
Sbjct: 2904 VKNLEGQD-AGTYTCTAENAVGRARRRVHLTILVLP-VFTTLPGDR----------SLRL 2951
Query: 238 GGTVTLTCEVPAQPSPQIHW 257
G + L C P+P+I W
Sbjct: 2952 GDRLWLRCAARGSPTPRIGW 2971
Score = 38.9 bits (89), Expect = 0.007
Identities = 24/74 (32%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVA--RVLPNGS-LFLPAVGIQ 78
G +T +G+PL L C+ A P ++W G P + +A +V G+ L + V +
Sbjct: 504 GLGQVTTIVGQPLELPCQ-ASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELD 562
Query: 79 DEGIFRCQAMNRNG 92
G+F CQA N G
Sbjct: 563 HSGLFACQATNEAG 576
Score = 35.0 bits (79), Expect = 0.097
Identities = 55/208 (26%), Positives = 73/208 (35%), Gaps = 17/208 (8%)
Query: 64 VLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGV 123
VL GSLFL +V D G + CQA N G T ++ VY P E D +G+
Sbjct: 53 VLEEGSLFLASVSPADSGDYECQATNEVG-STSRRAKLVVYVPPSIRE--DGRKANVSGM 109
Query: 124 PNKVGT--CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSE---- 177
+ T C + G +P + W D + LV G + + G L E
Sbjct: 110 AGQSLTLECDANG-FPVPEIVWLKDAQ-LVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSL 167
Query: 178 --LMVTPARGGDPRPTFSCSFSPGLPRHRAL---RTAPIQPRVWEPVPLEEVQLVVEPEG 232
+ P R G S P L P P P + E
Sbjct: 168 HFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEV 227
Query: 233 GAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
+A G V L C P+PQ+ W KD
Sbjct: 228 LGLA-GADVELQCWTSGVPTPQVEWTKD 254
Score = 33.5 bits (75), Expect = 0.28
Identities = 33/127 (25%), Positives = 47/127 (37%), Gaps = 26/127 (20%)
Query: 137 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 196
P + W D +P++P + V+E + L +T + GD +F
Sbjct: 245 PTPQVEWTKDRQPVLPGGPHLQVQEDGQ------------VLRITGSHVGDEGRYQCVAF 292
Query: 197 SPGLPRHRALRT---APIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSP 253
SP + R + AP P +W EV AV V L CE P+P
Sbjct: 293 SPAGQQARDFQLRVHAP--PTIWGSNETGEV---------AVMEDHLVQLLCEARGVPTP 341
Query: 254 QIHWMKD 260
I W KD
Sbjct: 342 NITWFKD 348
Score = 30.0 bits (66), Expect = 3.1
Identities = 34/129 (26%), Positives = 50/129 (38%), Gaps = 22/129 (17%)
Query: 138 AGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELM----VTPARGGDPRPTFS 193
AG H KP V KG S + H + G+ L+ + V+PA GD +
Sbjct: 21 AGGCGTHGTPKPQVTWRKGPSSEPL---HGQPGVAVLEEGSLFLASVSPADSGD----YE 73
Query: 194 CSFSP--GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQP 251
C + G RA + P + E V + G ++TL C+ P
Sbjct: 74 CQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMA---------GQSLTLECDANGFP 124
Query: 252 SPQIHWMKD 260
P+I W+KD
Sbjct: 125 VPEIVWLKD 133
Score = 28.9 bits (63), Expect = 7.0
Identities = 22/86 (25%), Positives = 32/86 (37%), Gaps = 4/86 (4%)
Query: 65 LPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVP 124
L NGSL + D G ++C A N G K V + + P ++T
Sbjct: 3077 LQNGSLTIHRTERDDAGRYQCLAENEMGVAKK----VVILVLQSAPVFQVEPQDMTVRSG 3132
Query: 125 NKVGTCVSEGSYPAGTLSWHLDGKPL 150
+ V P T+ W G+PL
Sbjct: 3133 DDVALRCQATGEPTPTIEWLQAGQPL 3158
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 67.0 bits (162), Expect = 2e-11
Identities = 82/276 (29%), Positives = 114/276 (41%), Gaps = 47/276 (17%)
Query: 25 NITARIGEPLVLKCK--GAPK------KPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVG 76
N+T P +L C+ G+PK K Q+L+++L G + R+LP+ +L L A G
Sbjct: 3772 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAY----RLLPSNALLLTAPG 3827
Query: 77 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TCVSEGS 135
QD F C N G E Y+V V+ +P P I D ++ T + V TC S G
Sbjct: 3828 PQDSAQFECVVSNEVG-EAHRLYQVTVH-VP--PTIADDQTDFTVTMMAPVVLTCHSTG- 3882
Query: 136 YPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCS 195
PA T+SW G L G V +G + L P G R T S
Sbjct: 3883 IPAPTVSWSKAGAQLGARGSGYRVS-------PSGALEIGQAL---PIHAG--RYTCSAR 3930
Query: 196 FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 255
S G+ T P V +P+P V+ V E E V L CE P P I
Sbjct: 3931 NSAGVAHKHVFLTVQASP-VVKPLP-SVVRAVAEEE---------VLLPCEASGIPRPTI 3979
Query: 256 HWMKDVSDLERGAGRTRRGGANCRLCGRIRAGNSSP 291
W K+ ++ G G G++R ++SP
Sbjct: 3980 TWQKEGLNVATGVSTQVLPG------GQLRIAHASP 4009
Score = 60.1 bits (144), Expect = 3e-09
Identities = 64/256 (25%), Positives = 105/256 (41%), Gaps = 35/256 (13%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGS---LFLPAVGIQ 78
G+ + +R GE + + C PP + W G P R L +GS L + V +
Sbjct: 3319 GSGTLVSRPGELVTMVCP-VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLA 3377
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 138
D GIF C A + G + N+ ++V Q+P E V+ +++ + V P
Sbjct: 3378 DAGIFTCVAASPAGVADR-NFTLQV-QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 3435
Query: 139 GTLSWHLDGKPLVPN--EKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 196
+SW DG+PL+ E+G S++ + ++G ++ V + G+ R F
Sbjct: 3436 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSC-----VAVSEAGEARRHF---- 3486
Query: 197 SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIH 256
Q V EP +E+ +P ++ PG + L C+ P P I
Sbjct: 3487 ---------------QLTVMEPPHIEDSG---QPTELSLTPGAPMELLCDAQGTPQPNIT 3528
Query: 257 WMKDVSDLERGAGRTR 272
W KD L R +R
Sbjct: 3529 WHKDGQALTRLENNSR 3544
Score = 55.1 bits (131), Expect = 9e-08
Identities = 68/246 (27%), Positives = 104/246 (42%), Gaps = 48/246 (19%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNG-SLFLPAVGIQDEGIFRCQAMN 89
G + L C+ A P + W G P +++ L G SL L AVG D G + C A++
Sbjct: 3421 GSLVELPCE-ARGVPLPLVSWMKDGEPL--LSQSLEQGPSLQLEAVGAGDSGTYSCVAVS 3477
Query: 90 RNGKETKSNYRVRVYQIPGKPEIVDSAS----ELTAGVPNKVGTCVSEGSYPAGTLSWHL 145
G E + ++++ V + P I DS LT G P ++ C ++G+ P ++WH
Sbjct: 3478 EAG-EARRHFQLTVME---PPHIEDSGQPTELSLTPGAPMEL-LCDAQGT-PQPNITWHK 3531
Query: 146 DGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRA 205
DG+ L E S + R + GL+T +E SP ++
Sbjct: 3532 DGQALTRLENN-SRATRVLRVRDAGLYTCLAE-------------------SPAGAIEKS 3571
Query: 206 LRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPG---GTVTLTCEVPAQPSPQIHWMKDVS 262
R RV P +V P G G G + L C V A+P+P+I W +D
Sbjct: 3572 FRV-----RVQAPPN------IVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGI 3620
Query: 263 DLERGA 268
L+ A
Sbjct: 3621 VLQEDA 3626
Score = 53.9 bits (128), Expect = 2e-07
Identities = 62/264 (23%), Positives = 105/264 (39%), Gaps = 37/264 (14%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRC 85
+ +GE VL C+ A PP R+ W GG +G L +PA +D G + C
Sbjct: 707 VLVAVGEEAVLVCE-ASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTC 765
Query: 86 QAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHL 145
+A+N G + + ++ V P ++ + ++T + P T++W
Sbjct: 766 RAVNELG-DASAEIQLAVGHAP---QLTELPRDVTVELGRSALLACRATGRPPPTVTWRR 821
Query: 146 -DGKPLVPNEKGVSV---KEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCS----FS 197
DG+PL G+ + + R P++G+ +S V P + + + C F
Sbjct: 822 GDGQPL-----GLRLGAGRGSRSRQPDSGVLFFES---VAP----EDQAPYVCEARNVFG 869
Query: 198 PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPA-QPSPQIH 256
R + T P++ P V G V+L C V A +P P+ H
Sbjct: 870 KVQAEARLIVTGHAPPQIASSAPTVRV-----------LEGQPVSLPCIVLAGRPLPERH 918
Query: 257 WMKDVSDLERGAGRTRRGGANCRL 280
W+KD L G+ + R + L
Sbjct: 919 WLKDGRPLPPGSRHSIRADGSLHL 942
Score = 52.4 bits (124), Expect = 6e-07
Identities = 63/243 (25%), Positives = 95/243 (39%), Gaps = 44/243 (18%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWDS-----VARVLPNGSLFLPAVGIQDEGIFRC 85
G+ + L C+ A +PP + W G P + L GSL L + D G + C
Sbjct: 3232 GQEVRLDCE-ADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 3290
Query: 86 QAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT--CVSEGSYPAGTLSW 143
A N G++ + + V V P + D + L + P ++ T C GS P +SW
Sbjct: 3291 VAHNPAGEDARL-HTVNVLVPPTIKQGADGSGTLVSR-PGELVTMVCPVRGSPPI-HVSW 3347
Query: 144 HLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFS 197
DG PL +++ G +++ + + G+FT + +PA D T
Sbjct: 3348 LKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC---VAASPAGVADRNFTLQVQVP 3404
Query: 198 PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHW 257
P V EPV + +VV G V L CE P P + W
Sbjct: 3405 P----------------VLEPVEFQNDVVVVR--------GSLVELPCEARGVPLPLVSW 3440
Query: 258 MKD 260
MKD
Sbjct: 3441 MKD 3443
Score = 50.8 bits (120), Expect = 2e-06
Identities = 58/253 (22%), Positives = 95/253 (37%), Gaps = 24/253 (9%)
Query: 11 VLVLSLWGAVVGAQ-NITARIGEPLVLKCKGAPKKPPQRLEWKLGG--GPWDSVARVLPN 67
VL + + +++G + N++ E + L+C+ PP WK G P V
Sbjct: 2064 VLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADK 2123
Query: 68 GSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKV 127
L + + D G + C+A+N+ G K +Y + V+ P P + G P +
Sbjct: 2124 ALLQVDRADVWDAGHYTCEALNQAGHSEK-HYNLNVWVAPVFPLRESHTLTVREGHPTSL 2182
Query: 128 GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 187
+C G P +SW DG+PL G+ R L+ Q++L +
Sbjct: 2183 -SCECRG-VPFPKISWRKDGQPLPGEGAGLQHVSAVGRL----LYLGQAQL------AQE 2230
Query: 188 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 247
T CS G + P++ P P +V G TL C
Sbjct: 2231 GTYTCECSNVVGNSSQDLQLEVHVPPQIAGPRE--------PPTQVSVVQDGVATLECNA 2282
Query: 248 PAQPSPQIHWMKD 260
+P P + W +D
Sbjct: 2283 TGKPPPTVTWERD 2295
Score = 50.1 bits (118), Expect = 3e-06
Identities = 65/251 (25%), Positives = 91/251 (36%), Gaps = 38/251 (15%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVG-------- 76
NITA + PL L C+ A PP + W G P V P +L A G
Sbjct: 2361 NITAALHSPLTLLCE-AMGIPPPAIRWFRGEEP------VSPGEDTYLLAGGWMLKMTQT 2413
Query: 77 -IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGS 135
QD G++ C A N G E + N+ V V +P E D + +
Sbjct: 2414 QEQDSGLYSCLASNEAG-EARRNFSVEVL-VPPSIENEDLEEVIKVLDGQTAHLMCNVTG 2471
Query: 136 YPAGTLSWHLDGKPLVPNE-KGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSC 194
+P L+W DG+PL + +S + + L + + G+ F
Sbjct: 2472 HPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQL 2531
Query: 195 SFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQ 254
S + AP E EEV + V ++L CE A PSP
Sbjct: 2532 S----------VLLAPTILGGAEDSADEEVTVTV---------NNPISLICEALAFPSPN 2572
Query: 255 IHWMKDVSDLE 265
I WMKD + E
Sbjct: 2573 ITWMKDGAPFE 2583
Score = 50.1 bits (118), Expect = 3e-06
Identities = 66/265 (24%), Positives = 110/265 (41%), Gaps = 37/265 (13%)
Query: 2 AAGTAVGAWVLVLSLWGAVV-GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDS 60
+AG+A+G LV+ + + G +++ G L CK A P + W G P
Sbjct: 4022 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCK-ARGSPEPNITWDKDGQPVSG 4080
Query: 61 VA---RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSAS 117
+ P+G L + + QD G + C A N G+ + RV + I P
Sbjct: 4081 AEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR---RVHL-TILVLPVFTTLPG 4136
Query: 118 ELTAGVPNKVGT-CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQS 176
+ + + +++ C + GS P + W ++ +P+ +GVS ++ G TLQ
Sbjct: 4137 DRSLRLGDRLWLRCAARGS-PTPRIGWTVNDRPVT---EGVSEQD--------GGSTLQR 4184
Query: 177 ELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEV-QLVVEPEGGAV 235
+ G T+ C + R +A+ ++ PV E +VEP GG++
Sbjct: 4185 AAVSREDSG-----TYVCWAENRVGRTQAVSFVHVKEA---PVLQGEAFSYLVEPVGGSI 4236
Query: 236 APGGTVTLTCEVPAQPSPQIHWMKD 260
L C V P P IHW+KD
Sbjct: 4237 Q------LDCVVRGDPVPDIHWIKD 4255
Score = 49.7 bits (117), Expect = 4e-06
Identities = 66/287 (22%), Positives = 112/287 (39%), Gaps = 44/287 (15%)
Query: 3 AGTAVGAWVLVLSLWGAVVGA--QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDS 60
AG+A + L + + + G + +TA + + L C P+ +K DS
Sbjct: 2922 AGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK------DS 2975
Query: 61 VARVLPNGSLFLPAVG--------IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEI 112
A L LP + D G++ C+A+N G++ K ++ V P +
Sbjct: 2976 QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL-VQLSVLVPPAFRQA 3034
Query: 113 VDSASE-LTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGL 171
+ + V +K + P T++W+ DG+PLV ++ +++ R
Sbjct: 3035 PRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR------- 3087
Query: 172 FTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQ-PRVWEPVPLEEVQLVVEP 230
L + A+ D + +SC S T +Q P +E E V V
Sbjct: 3088 ------LEIQEAQVSD-KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVA-- 3138
Query: 231 EGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERGA--GRTRRGG 275
G + LTC+V P+P + W+KD +E A G RGG
Sbjct: 3139 -------GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG 3178
Score = 49.3 bits (116), Expect = 5e-06
Identities = 61/251 (24%), Positives = 103/251 (41%), Gaps = 33/251 (13%)
Query: 11 VLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGP-WDSVARVLPNGS 69
+LVL ++ + G +++ R+G+ L L+C A P R+ W + P + V+ +
Sbjct: 4125 ILVLPVFTTLPGDRSL--RLGDRLWLRC-AARGSPTPRIGWTVNDRPVTEGVSEQDGGST 4181
Query: 70 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT 129
L AV +D G + C A NR G+ ++ V V + P ++ S L V +
Sbjct: 4182 LQRAAVSREDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQG--EAFSYLVEPVGGSIQL 4238
Query: 130 -CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDP 188
CV G P + W DG PL +G ++ Q LQ+ + D
Sbjct: 4239 DCVVRGD-PVPDIHWIKDGLPL----RGSHLRHQ-----------LQNGSLTIHRTERDD 4282
Query: 189 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 248
+ C L + + V + P+ +V EP+ V G V L C+
Sbjct: 4283 AGRYQC-----LAENEMGVAKKVVILVLQSAPVFQV----EPQDMTVRSGDDVALRCQAT 4333
Query: 249 AQPSPQIHWMK 259
+P+P I W++
Sbjct: 4334 GEPTPTIEWLQ 4344
Score = 48.9 bits (115), Expect = 7e-06
Identities = 64/244 (26%), Positives = 103/244 (42%), Gaps = 34/244 (13%)
Query: 20 VVGAQNITARIGEPLVLKCK---GAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVG 76
+V A N+T GE VL C+ AP +W++ VA+ L + SL + +
Sbjct: 520 LVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQ-LADLSLEISGII 578
Query: 77 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSY 136
D G ++C A N NG T+++ + V + P + I S+ + GV KV +C + G Y
Sbjct: 579 PTDGGRYQCVASNANG-VTRASVWLLVREAP-QVSIHTSSQHFSQGVEVKV-SCSASG-Y 634
Query: 137 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPET-GLFTLQSELMVTPARGGDPRPTFSCS 195
P +SW + + L +E +R H + G +Q V P G+ +SC
Sbjct: 635 PTPHISWSRESQAL---------QEDSRIHVDAQGTLIIQG---VAPEDAGN----YSCQ 678
Query: 196 FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 255
+ + + T +P + V VV VA G L CE P P++
Sbjct: 679 ATNEVGTDQETVTL----YYTDPPSVSAVNAVV-----LVAVGEEAVLVCEASGVPPPRV 729
Query: 256 HWMK 259
W +
Sbjct: 730 IWYR 733
Score = 47.8 bits (112), Expect = 1e-05
Identities = 71/267 (26%), Positives = 106/267 (39%), Gaps = 43/267 (16%)
Query: 3 AGTAVGAWVLVLSLWGAVV-GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSV 61
AG+A +VL + + V G + + +GE L L C PQ L W G
Sbjct: 1105 AGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQ-LSWSKDGVVLQGR 1163
Query: 62 ARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIP--GKPE---IVDSA 116
P GS+ A+ D G +RC+A N G + +RV + P G E +++
Sbjct: 1164 G---PQGSVHFAAIRTSDAGRYRCEASNSAGVDA-WEVELRVLEPPHWGADETSGLLERV 1219
Query: 117 SELTAGVPNKV-GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQ 175
+ A +P GT + ++ G S L G+P GV+V E E LF
Sbjct: 1220 AGENASLPCPARGTPKPQVTWRKGPSSEPLHGQP------GVAVLE------EGSLFLAS 1267
Query: 176 SELMVTPARGGDPRPTFSCSFS--PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGG 233
V+PA GD + C + G RA + P + E V +
Sbjct: 1268 ----VSPADSGD----YECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMA----- 1314
Query: 234 AVAPGGTVTLTCEVPAQPSPQIHWMKD 260
G ++TL C+ P P+I W+KD
Sbjct: 1315 ----GQSLTLECDANGFPVPEIVWLKD 1337
Score = 47.4 bits (111), Expect = 2e-05
Identities = 54/199 (27%), Positives = 84/199 (42%), Gaps = 38/199 (19%)
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIP------GKPEIVDSASELTAGVPNKVGTCVS 132
D G++ C+A N G K+ R+ VY P G+P +V + AG P + CV+
Sbjct: 1567 DAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAV----AGRPVAL-ECVA 1620
Query: 133 EGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTF 192
G +P+ TLSWH +G P V+ ++R + + L+S G +
Sbjct: 1621 RG-HPSPTLSWHHEGLP-------VAESNESRLETDGSVLRLESP-------GEASSGLY 1665
Query: 193 SCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP--GGTVTLTCEVPAQ 250
SC S P A+ ++ +V QL+V G V G + L C+
Sbjct: 1666 SCVASS--PAGEAVLQYSVEVQV-------PPQLLVAEGLGQVTTIVGQPLELPCQASGS 1716
Query: 251 PSPQIHWMKDVSDLERGAG 269
P P I W+++ E AG
Sbjct: 1717 PVPTIQWLQNGRPAEELAG 1735
Score = 47.4 bits (111), Expect = 2e-05
Identities = 68/237 (28%), Positives = 94/237 (39%), Gaps = 38/237 (16%)
Query: 32 EPLVLKCKGAPKKPPQRLEWKLGGGPWDS-----VARVLPNGSLFLPAVGIQDEGIFRCQ 86
+P V + GA KPP W G W VA LP L + V ++DEGI+ C
Sbjct: 1808 DPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPP-PLQIEKVDLRDEGIYTCA 1866
Query: 87 AMNRNGKETKSNYRVRVYQIPG-KPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHL 145
A N G E+K ++V P +P V+ A A V + C++ G P +SW
Sbjct: 1867 ATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLE---CLASG-VPPPDVSWFK 1921
Query: 146 DGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFS--PGLPRH 203
+P V + GV+V R L + A+ D ++ C S G
Sbjct: 1922 GHQP-VSSWMGVTVSVDGR------------VLRIEQAQLSDAG-SYRCVASNVAGSTEL 1967
Query: 204 RALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
R + PR+ P L LV P V LTC PSP + W+KD
Sbjct: 1968 RYGLRVNVPPRITLPPSLPGPVLVNTP----------VRLTCNATGAPSPTLMWLKD 2014
Score = 47.0 bits (110), Expect = 2e-05
Identities = 57/252 (22%), Positives = 97/252 (38%), Gaps = 33/252 (13%)
Query: 45 PPQRLEWKLGGGPW---DSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRV 101
PP L W P D V+ + L +P V ++ G + C+A N G++ +Y +
Sbjct: 2778 PPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWL-HYEL 2836
Query: 102 RVYQIP---GKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVS 158
V P G E + E+T + V P T+SW +G P P+ +
Sbjct: 2837 LVLTPPVILGDTE--ELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQV 2894
Query: 159 VKE-QTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWE 217
+++ Q + + S + V + G F+ + PR+
Sbjct: 2895 LEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ-------------VPPRI-A 2940
Query: 218 PVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERGAGRTRRGGAN 277
+ LE+V ++ +V+L C+V A P+P++ W KD L G G +
Sbjct: 2941 GLDLEQVTAILN---------SSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH 2991
Query: 278 CRLCGRIRAGNS 289
GR R +S
Sbjct: 2992 TLQLGRARLSDS 3003
Score = 46.2 bits (108), Expect = 4e-05
Identities = 61/230 (26%), Positives = 92/230 (40%), Gaps = 31/230 (13%)
Query: 45 PPQRLEWKLGGGP---WDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRV 101
PP + W G P W V + L + + D G +RC A N G T+ Y +
Sbjct: 1913 PPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS-TELRYGL 1971
Query: 102 RVYQIPGKPEIVDSA-SELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVP-NEKGVSV 159
RV +P + + S + P ++ TC + G+ P+ TL W DG P+ P G+ V
Sbjct: 1972 RV-NVPPRITLPPSLPGPVLVNTPVRL-TCNATGA-PSPTLMWLKDGNPVSPAGTPGLQV 2028
Query: 160 KEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPV 219
P + TL S AR D +SC + R + +Q + +
Sbjct: 2029 ------FPGGRVLTLAS------ARASDSG-RYSCVAVSAVGEDR--QDVVLQVHMPPSI 2073
Query: 220 PLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERGAG 269
EE+ + +V +V L C+ A P P + W KD LE G
Sbjct: 2074 LGEELNV-------SVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPG 2116
Score = 45.8 bits (107), Expect = 6e-05
Identities = 31/93 (33%), Positives = 48/93 (51%), Gaps = 7/93 (7%)
Query: 21 VGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARV--LPNGSLFLPAVGIQ 78
V Q++T R G+ + L+C+ A +P +EW G P + R+ LP+GSL+L V
Sbjct: 4313 VEPQDMTVRSGDDVALRCQ-ATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG 4371
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPE 111
D G + C A N G T + V + G+P+
Sbjct: 4372 DAGTYDCVAHNLLGSATARAFLV----VRGEPQ 4400
Score = 45.4 bits (106), Expect = 7e-05
Identities = 59/252 (23%), Positives = 92/252 (36%), Gaps = 39/252 (15%)
Query: 24 QNITARIGEPLVLKCKGAPKKPP---------QRLEWKLGGGPWDSVARVLPNGSLFLPA 74
+++T +G +L C+ + PP Q L +LG G S +R +G LF +
Sbjct: 793 RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR-GSRSRQPDSGVLFFES 851
Query: 75 VGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSAS--ELTAGVPNKVGTCVS 132
V +D+ + C+A N GK + P P+I SA + G P + C+
Sbjct: 852 VAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP--PQIASSAPTVRVLEGQPVSL-PCIV 908
Query: 133 EGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTF 192
P W DG+PL P + S++ H + L + +
Sbjct: 909 LAGRPLPERHWLKDGRPLPPGSRH-SIRADGSLHLDRAL--------------QEHAGRY 953
Query: 193 SCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPS 252
SC A TA Q R E V ++ G +L C P+
Sbjct: 954 SCV---------ATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 1004
Query: 253 PQIHWMKDVSDL 264
P I W K+ + L
Sbjct: 1005 PTITWTKETNAL 1016
Score = 45.4 bits (106), Expect = 7e-05
Identities = 63/251 (25%), Positives = 98/251 (39%), Gaps = 36/251 (14%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARV--LPNGS-LFLPAVGIQDEGI 82
+ R+G+ VL C+ P + W G P R L G L + + D+G+
Sbjct: 3042 VLVRVGDKAVLSCE-TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGL 3100
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNK--VGTCVSEGSYPAGT 140
+ C+ N G+ ++ + + V Q+P P + +E + V V TC G PA T
Sbjct: 3101 YSCKVSNVAGEAVRT-FTLTV-QVP--PTFENPKTETVSQVAGSPLVLTCDVSG-VPAPT 3155
Query: 141 LSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSC--SFSP 198
++W D P+ + +V R L LQ PA+ G T++C +
Sbjct: 3156 VTWLKDRMPV----ESSAVHGVVSRGGRLQLSRLQ------PAQAG----TYTCVAENTQ 3201
Query: 199 GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 258
R + + PR+ E V G V L CE QP P + W+
Sbjct: 3202 AEARKDFVVAVLVAPRIRSSGVAREHH---------VLEGQEVRLDCEADGQPPPDVAWL 3252
Query: 259 KDVSDLERGAG 269
KD S L + G
Sbjct: 3253 KDGSPLGQDMG 3263
Score = 45.4 bits (106), Expect = 7e-05
Identities = 65/256 (25%), Positives = 99/256 (38%), Gaps = 38/256 (14%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVA---RVLPNGSLFLPAVGIQ 78
G + + + +L C+ A P + W+ P D + +LP GSL + V Q
Sbjct: 3678 GPPAVNVSVNQTALLPCQ-ADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQ 3736
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE--LTAGVPNKVGTCVSEGSY 136
D G + C A N G + + R ++ P I S S LTA P + C + GS
Sbjct: 3737 DAGHYLCLASNSAGSDRQG----RDLRVLEPPAIAPSPSNLTLTAHTPALL-PCEASGS- 3790
Query: 137 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 196
P + W DG+ L R + L S ++ A G F C
Sbjct: 3791 PKPLVVWWKDGQKL------------DFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVV 3838
Query: 197 SPGL-PRHRALR-TAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQ 254
S + HR + T + P + + ++ V +AP V LTC P+P
Sbjct: 3839 SNEVGEAHRLYQVTVHVPPTIAD----DQTDFTVT----MMAP---VVLTCHSTGIPAPT 3887
Query: 255 IHWMKDVSDL-ERGAG 269
+ W K + L RG+G
Sbjct: 3888 VSWSKAGAQLGARGSG 3903
Score = 45.1 bits (105), Expect = 9e-05
Identities = 56/241 (23%), Positives = 89/241 (36%), Gaps = 38/241 (15%)
Query: 36 LKCKGAPKKPPQRLEWKLGGGPWDS-VARVLPNG--SLFLPAVGIQDEGIFRCQAMNRNG 92
L+C A KPP + W+ G P + + L N SL + G + C A N G
Sbjct: 2278 LECN-ATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG 2336
Query: 93 KETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVP 152
+ + + + V P +D + +TA + + + P + W +P+ P
Sbjct: 2337 RAERK-FELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 2395
Query: 153 NEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRAL 206
E G +K + ++GL++ + G+ R FS
Sbjct: 2396 GEDTYLLAGGWMLKMTQTQEQDSGLYSC-----LASNEAGEARRNFSVEV---------- 2440
Query: 207 RTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLER 266
+ P E LEEV V++ G T L C V P P++ W KD L R
Sbjct: 2441 ----LVPPSIENEDLEEVIKVLD--------GQTAHLMCNVTGHPQPKLTWFKDGRPLAR 2488
Query: 267 G 267
G
Sbjct: 2489 G 2489
Score = 44.7 bits (104), Expect = 1e-04
Identities = 65/266 (24%), Positives = 98/266 (36%), Gaps = 65/266 (24%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEW----KLGGGP-----------WDSVA--RVLPN 67
N++ G+ L L+C A P + W +L G P W V R+L
Sbjct: 1309 NVSGMAGQSLTLECD-ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE 1367
Query: 68 G-SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNK 126
G SL P + D G++ C+A N+ G + + + ++ S L AG +
Sbjct: 1368 GQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLL----------VLTPPSVLGAGAAQE 1417
Query: 127 VG---------TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSE 177
V C + G P + W D +P++P + V+E +
Sbjct: 1418 VLGLAGADVELQCWTSG-VPTPQVEWTKDRQPVLPGGPHLQVQEDGQ------------V 1464
Query: 178 LMVTPARGGDPRPTFSCSFSPGLPRHRALRT---APIQPRVWEPVPLEEVQLVVEPEGGA 234
L +T + GD +FSP + R + AP P +W EV A
Sbjct: 1465 LRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP--PTIWGSNETGEV---------A 1513
Query: 235 VAPGGTVTLTCEVPAQPSPQIHWMKD 260
V V L CE P+P I W KD
Sbjct: 1514 VMEDHLVQLLCEARGVPTPNITWFKD 1539
Score = 43.1 bits (100), Expect = 4e-04
Identities = 58/264 (21%), Positives = 102/264 (38%), Gaps = 38/264 (14%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARV-LPNGSLFLPAVGIQ--DE 80
+ +T + P+ L C+ A P + W G P+++ + L G+ L + Q D
Sbjct: 2549 EEVTVTVNNPISLICE-ALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDA 2607
Query: 81 GIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASEL-TAGVPNKVGTCVS----EGS 135
G + C N G+ K NY V V IP D E+ V KV + ++ +
Sbjct: 2608 GQYTCVVTNELGEAVK-NYHVEVL-IPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWA 2665
Query: 136 YPAGTLSWHLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPR 189
P T+ W+ DG+P+ P+ + G ++ Q + ++G + L V G+
Sbjct: 2666 VPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY-----LCVATNVAGEDD 2720
Query: 190 PTFSCSFSPGLPRHRALRTAPIQPRVWE-PVPLEEVQLVVEPEGGA-----VAPGGTVTL 243
F+ ++ P+ +V + E + E GG + L
Sbjct: 2721 QDFNV----------LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYL 2770
Query: 244 TCEVPAQPSPQIHWMKDVSDLERG 267
C+ A P P + W ++ L G
Sbjct: 2771 YCDTNAIPPPDLTWYREDQPLSAG 2794
Score = 40.4 bits (93), Expect = 0.002
Identities = 51/208 (24%), Positives = 74/208 (35%), Gaps = 49/208 (23%)
Query: 64 VLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGV 123
+LP+GSL L V + D G + C A N G + S+ V Q+P P++ L V
Sbjct: 1078 LLPSGSLRLAQVQVGDSGHYECTASNPAG--SASHRYVLGVQVP--PQVQPGPRVLKVLV 1133
Query: 124 PNKVG-TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTP 182
+ CV+EG+ P LSW DG +V
Sbjct: 1134 GEALDLNCVAEGN-PEPQLSWSKDG-------------------------------VVLQ 1161
Query: 183 ARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGG--- 239
RG F+ + R+R + WE E++++ P GA G
Sbjct: 1162 GRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWE----VELRVLEPPHWGADETSGLLE 1217
Query: 240 -----TVTLTCEVPAQPSPQIHWMKDVS 262
+L C P PQ+ W K S
Sbjct: 1218 RVAGENASLPCPARGTPKPQVTWRKGPS 1245
Score = 39.3 bits (90), Expect = 0.005
Identities = 62/263 (23%), Positives = 100/263 (38%), Gaps = 47/263 (17%)
Query: 21 VGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR--VLPNGSLF-LPAVGI 77
VG + + ++ L L+C+ + PP + W G P +R VL G L + +
Sbjct: 2644 VGVKEVKTKVNSTLTLECE-SWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQV 2702
Query: 78 QDEGIFRCQAMNRNGKETKS-NYRVRVYQIPGKP-------EIVDSASELTAGVP----- 124
D G + C A N G++ + N ++V + K EI+ E GV
Sbjct: 2703 SDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREI 2762
Query: 125 ---NKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 181
N + P L+W+ + +PL ++ VSV + R LQ L+
Sbjct: 2763 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE-VSVLQGGR--------VLQIPLVRA 2813
Query: 182 PARGGDPRPTFSCSFSPGLP----RHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP 237
G +SC S + + L P PV L + + +VE V
Sbjct: 2814 ENAG-----RYSCKASNEVGEDWLHYELLVLTP-------PVILGDTEELVEEV--TVNA 2859
Query: 238 GGTVTLTCEVPAQPSPQIHWMKD 260
TV+L C P P I W+++
Sbjct: 2860 SSTVSLQCPALGNPVPTISWLQN 2882
Score = 39.3 bits (90), Expect = 0.005
Identities = 52/200 (26%), Positives = 80/200 (40%), Gaps = 37/200 (18%)
Query: 63 RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASEL-TA 121
+VLP G L + +D G + C A N G V Q+P P I + +L T
Sbjct: 3995 QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTR--LVVQVP--PVIENGLPDLSTT 4050
Query: 122 GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQ--SELM 179
+ C + GS P ++W DG+P+ E G FT+Q EL+
Sbjct: 4051 EGSHAFLPCKARGS-PEPNITWDKDGQPVSGAE---------------GKFTIQPSGELL 4094
Query: 180 VTPARGGDPRPTFSCSF--SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP 237
V G D T++C+ + G R R T + P V+ +P + ++
Sbjct: 4095 VKNLEGQD-AGTYTCTAENAVGRARRRVHLTILVLP-VFTTLPGDR----------SLRL 4142
Query: 238 GGTVTLTCEVPAQPSPQIHW 257
G + L C P+P+I W
Sbjct: 4143 GDRLWLRCAARGSPTPRIGW 4162
Score = 38.9 bits (89), Expect = 0.007
Identities = 48/158 (30%), Positives = 66/158 (41%), Gaps = 26/158 (16%)
Query: 7 VGAWVLVLSL-----WGAVVGAQNITARIGEPLVLKC--KGAPKKPPQRLEWKLG----- 54
V AW + L + WGA + + GE L C +G PK PQ + W+ G
Sbjct: 1192 VDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPK--PQ-VTWRKGPSSEP 1248
Query: 55 --GGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEI 112
G P VL GSLFL +V D G + CQA N G T ++ VY P E
Sbjct: 1249 LHGQPG---VAVLEEGSLFLASVSPADSGDYECQATNEVG-STSRRAKLVVYVPPSIRE- 1303
Query: 113 VDSASELTAGVPNKVGT--CVSEGSYPAGTLSWHLDGK 148
D +G+ + T C + G +P + W D +
Sbjct: 1304 -DGRKANVSGMAGQSLTLECDANG-FPVPEIVWLKDAQ 1339
Score = 38.9 bits (89), Expect = 0.007
Identities = 24/74 (32%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVA--RVLPNGS-LFLPAVGIQ 78
G +T +G+PL L C+ A P ++W G P + +A +V G+ L + V +
Sbjct: 1695 GLGQVTTIVGQPLELPCQ-ASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELD 1753
Query: 79 DEGIFRCQAMNRNG 92
G+F CQA N G
Sbjct: 1754 HSGLFACQATNEAG 1767
Score = 35.8 bits (81), Expect = 0.057
Identities = 52/218 (23%), Positives = 76/218 (34%), Gaps = 33/218 (15%)
Query: 59 DSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE 118
DS V G+L + V +D G + CQA N G + ++ V +Y +A
Sbjct: 651 DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQET---VTLYYTDPPSVSAVNAVV 707
Query: 119 LTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSEL 178
L A V C + G P + W+ G ++ +G S S
Sbjct: 708 LVAVGEEAVLVCEASG-VPPPRVIWYRGGLEMILAPEGSS-----------------SGK 749
Query: 179 MVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPG 238
+ PA T++C L +A IQ V L E+ P V G
Sbjct: 750 LRIPAAQERDAGTYTCRAVNEL----GDASAEIQLAVGHAPQLTEL-----PRDVTVELG 800
Query: 239 GTVTLTCEVPAQPSPQIHWMKDVSD---LERGAGRTRR 273
+ L C +P P + W + L GAGR R
Sbjct: 801 RSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSR 838
Score = 28.9 bits (63), Expect = 7.0
Identities = 21/62 (33%), Positives = 28/62 (45%), Gaps = 5/62 (8%)
Query: 209 APIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERGA 268
A Q V +P P QLV P V+PG T L+C V + + W++D L
Sbjct: 507 AKAQIVVTDPPP----QLVPAPNV-TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST 561
Query: 269 GR 270
GR
Sbjct: 562 GR 563
Score = 28.9 bits (63), Expect = 7.0
Identities = 22/86 (25%), Positives = 32/86 (37%), Gaps = 4/86 (4%)
Query: 65 LPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVP 124
L NGSL + D G ++C A N G K V + + P ++T
Sbjct: 4268 LQNGSLTIHRTERDDAGRYQCLAENEMGVAKK----VVILVLQSAPVFQVEPQDMTVRSG 4323
Query: 125 NKVGTCVSEGSYPAGTLSWHLDGKPL 150
+ V P T+ W G+PL
Sbjct: 4324 DDVALRCQATGEPTPTIEWLQAGQPL 4349
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 67.0 bits (162), Expect = 2e-11
Identities = 82/276 (29%), Positives = 114/276 (41%), Gaps = 47/276 (17%)
Query: 25 NITARIGEPLVLKCK--GAPK------KPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVG 76
N+T P +L C+ G+PK K Q+L+++L G + R+LP+ +L L A G
Sbjct: 2490 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAY----RLLPSNALLLTAPG 2545
Query: 77 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TCVSEGS 135
QD F C N G E Y+V V+ +P P I D ++ T + V TC S G
Sbjct: 2546 PQDSAQFECVVSNEVG-EAHRLYQVTVH-VP--PTIADDQTDFTVTMMAPVVLTCHSTG- 2600
Query: 136 YPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCS 195
PA T+SW G L G V +G + L P G R T S
Sbjct: 2601 IPAPTVSWSKAGAQLGARGSGYRVS-------PSGALEIGQAL---PIHAG--RYTCSAR 2648
Query: 196 FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 255
S G+ T P V +P+P V+ V E E V L CE P P I
Sbjct: 2649 NSAGVAHKHVFLTVQASP-VVKPLP-SVVRAVAEEE---------VLLPCEASGIPRPTI 2697
Query: 256 HWMKDVSDLERGAGRTRRGGANCRLCGRIRAGNSSP 291
W K+ ++ G G G++R ++SP
Sbjct: 2698 TWQKEGLNVATGVSTQVLPG------GQLRIAHASP 2727
Score = 60.1 bits (144), Expect = 3e-09
Identities = 64/256 (25%), Positives = 105/256 (41%), Gaps = 35/256 (13%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGS---LFLPAVGIQ 78
G+ + +R GE + + C PP + W G P R L +GS L + V +
Sbjct: 2037 GSGTLVSRPGELVTMVCP-VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLA 2095
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 138
D GIF C A + G + N+ ++V Q+P E V+ +++ + V P
Sbjct: 2096 DAGIFTCVAASPAGVADR-NFTLQV-QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 2153
Query: 139 GTLSWHLDGKPLVPN--EKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 196
+SW DG+PL+ E+G S++ + ++G ++ V + G+ R F
Sbjct: 2154 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSC-----VAVSEAGEARRHF---- 2204
Query: 197 SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIH 256
Q V EP +E+ +P ++ PG + L C+ P P I
Sbjct: 2205 ---------------QLTVMEPPHIEDSG---QPTELSLTPGAPMELLCDAQGTPQPNIT 2246
Query: 257 WMKDVSDLERGAGRTR 272
W KD L R +R
Sbjct: 2247 WHKDGQALTRLENNSR 2262
Score = 55.1 bits (131), Expect = 9e-08
Identities = 68/246 (27%), Positives = 104/246 (42%), Gaps = 48/246 (19%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNG-SLFLPAVGIQDEGIFRCQAMN 89
G + L C+ A P + W G P +++ L G SL L AVG D G + C A++
Sbjct: 2139 GSLVELPCE-ARGVPLPLVSWMKDGEPL--LSQSLEQGPSLQLEAVGAGDSGTYSCVAVS 2195
Query: 90 RNGKETKSNYRVRVYQIPGKPEIVDSAS----ELTAGVPNKVGTCVSEGSYPAGTLSWHL 145
G E + ++++ V + P I DS LT G P ++ C ++G+ P ++WH
Sbjct: 2196 EAG-EARRHFQLTVME---PPHIEDSGQPTELSLTPGAPMEL-LCDAQGT-PQPNITWHK 2249
Query: 146 DGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRA 205
DG+ L E S + R + GL+T +E SP ++
Sbjct: 2250 DGQALTRLENN-SRATRVLRVRDAGLYTCLAE-------------------SPAGAIEKS 2289
Query: 206 LRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPG---GTVTLTCEVPAQPSPQIHWMKDVS 262
R RV P +V P G G G + L C V A+P+P+I W +D
Sbjct: 2290 FRV-----RVQAPPN------IVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGI 2338
Query: 263 DLERGA 268
L+ A
Sbjct: 2339 VLQEDA 2344
Score = 52.4 bits (124), Expect = 6e-07
Identities = 63/243 (25%), Positives = 95/243 (39%), Gaps = 44/243 (18%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWDS-----VARVLPNGSLFLPAVGIQDEGIFRC 85
G+ + L C+ A +PP + W G P + L GSL L + D G + C
Sbjct: 1950 GQEVRLDCE-ADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2008
Query: 86 QAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT--CVSEGSYPAGTLSW 143
A N G++ + + V V P + D + L + P ++ T C GS P +SW
Sbjct: 2009 VAHNPAGEDARL-HTVNVLVPPTIKQGADGSGTLVSR-PGELVTMVCPVRGSPPI-HVSW 2065
Query: 144 HLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFS 197
DG PL +++ G +++ + + G+FT + +PA D T
Sbjct: 2066 LKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC---VAASPAGVADRNFTLQVQVP 2122
Query: 198 PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHW 257
P V EPV + +VV G V L CE P P + W
Sbjct: 2123 P----------------VLEPVEFQNDVVVVR--------GSLVELPCEARGVPLPLVSW 2158
Query: 258 MKD 260
MKD
Sbjct: 2159 MKD 2161
Score = 51.6 bits (122), Expect = 1e-06
Identities = 58/253 (22%), Positives = 96/253 (37%), Gaps = 24/253 (9%)
Query: 11 VLVLSLWGAVVGAQ-NITARIGEPLVLKCKGAPKKPPQRLEWKLGG--GPWDSVARVLPN 67
VL + + +++G + N++ E + L+C+ PP WK G P V
Sbjct: 782 VLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADK 841
Query: 68 GSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKV 127
L + + D G + C+A+N+ G K +Y + V+ P P + G P ++
Sbjct: 842 ALLQVDRADVWDAGHYTCEALNQAGHSEK-HYNLNVWVAPVFPLRESHTLTVREGHPTRL 900
Query: 128 GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 187
+C G P +SW DG+PL G+ R L+ Q++L +
Sbjct: 901 -SCECRG-VPFPKISWRKDGQPLPGEGAGLQHVSAVGRL----LYLGQAQL------AQE 948
Query: 188 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 247
T CS G + P++ P P +V G TL C
Sbjct: 949 GTYTCECSNVVGNSSQDLQLEVHVPPQIAGPRE--------PPTQVSVVQDGVATLECNA 1000
Query: 248 PAQPSPQIHWMKD 260
+P P + W +D
Sbjct: 1001 TGKPPPTVTWERD 1013
Score = 50.1 bits (118), Expect = 3e-06
Identities = 65/251 (25%), Positives = 91/251 (36%), Gaps = 38/251 (15%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVG-------- 76
NITA + PL L C+ A PP + W G P V P +L A G
Sbjct: 1079 NITAALHSPLTLLCE-AMGIPPPAIRWFRGEEP------VSPGEDTYLLAGGWMLKMTQT 1131
Query: 77 -IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGS 135
QD G++ C A N G E + N+ V V +P E D + +
Sbjct: 1132 QEQDSGLYSCLASNEAG-EARRNFSVEVL-VPPSIENEDLEEVIKVLDGQTAHLMCNVTG 1189
Query: 136 YPAGTLSWHLDGKPLVPNE-KGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSC 194
+P L+W DG+PL + +S + + L + + G+ F
Sbjct: 1190 HPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQL 1249
Query: 195 SFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQ 254
S + AP E EEV + V ++L CE A PSP
Sbjct: 1250 S----------VLLAPTILGGAEDSADEEVTVTV---------NNPISLICEALAFPSPN 1290
Query: 255 IHWMKDVSDLE 265
I WMKD + E
Sbjct: 1291 ITWMKDGAPFE 1301
Score = 50.1 bits (118), Expect = 3e-06
Identities = 66/265 (24%), Positives = 110/265 (41%), Gaps = 37/265 (13%)
Query: 2 AAGTAVGAWVLVLSLWGAVV-GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDS 60
+AG+A+G LV+ + + G +++ G L CK A P + W G P
Sbjct: 2740 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCK-ARGSPEPNITWDKDGQPVSG 2798
Query: 61 VA---RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSAS 117
+ P+G L + + QD G + C A N G+ + RV + I P
Sbjct: 2799 AEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR---RVHL-TILVLPVFTTLPG 2854
Query: 118 ELTAGVPNKVGT-CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQS 176
+ + + +++ C + GS P + W ++ +P+ +GVS ++ G TLQ
Sbjct: 2855 DRSLRLGDRLWLRCAARGS-PTPRIGWTVNDRPVT---EGVSEQD--------GGSTLQR 2902
Query: 177 ELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEV-QLVVEPEGGAV 235
+ G T+ C + R +A+ ++ PV E +VEP GG++
Sbjct: 2903 AAVSREDSG-----TYVCWAENRVGRTQAVSFVHVKEA---PVLQGEAFSYLVEPVGGSI 2954
Query: 236 APGGTVTLTCEVPAQPSPQIHWMKD 260
L C V P P IHW+KD
Sbjct: 2955 Q------LDCVVRGDPVPDIHWIKD 2973
Score = 49.7 bits (117), Expect = 4e-06
Identities = 66/287 (22%), Positives = 112/287 (39%), Gaps = 44/287 (15%)
Query: 3 AGTAVGAWVLVLSLWGAVVGA--QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDS 60
AG+A + L + + + G + +TA + + L C P+ +K DS
Sbjct: 1640 AGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK------DS 1693
Query: 61 VARVLPNGSLFLPAVG--------IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEI 112
A L LP + D G++ C+A+N G++ K ++ V P +
Sbjct: 1694 QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL-VQLSVLVPPAFRQA 1752
Query: 113 VDSASE-LTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGL 171
+ + V +K + P T++W+ DG+PLV ++ +++ R
Sbjct: 1753 PRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR------- 1805
Query: 172 FTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQ-PRVWEPVPLEEVQLVVEP 230
L + A+ D + +SC S T +Q P +E E V V
Sbjct: 1806 ------LEIQEAQVSD-KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVA-- 1856
Query: 231 EGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERGA--GRTRRGG 275
G + LTC+V P+P + W+KD +E A G RGG
Sbjct: 1857 -------GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG 1896
Score = 49.3 bits (116), Expect = 5e-06
Identities = 61/251 (24%), Positives = 103/251 (41%), Gaps = 33/251 (13%)
Query: 11 VLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGP-WDSVARVLPNGS 69
+LVL ++ + G +++ R+G+ L L+C A P R+ W + P + V+ +
Sbjct: 2843 ILVLPVFTTLPGDRSL--RLGDRLWLRC-AARGSPTPRIGWTVNDRPVTEGVSEQDGGST 2899
Query: 70 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT 129
L AV +D G + C A NR G+ ++ V V + P ++ S L V +
Sbjct: 2900 LQRAAVSREDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQG--EAFSYLVEPVGGSIQL 2956
Query: 130 -CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDP 188
CV G P + W DG PL +G ++ Q LQ+ + D
Sbjct: 2957 DCVVRGD-PVPDIHWIKDGLPL----RGSHLRHQ-----------LQNGSLTIRRTERDD 3000
Query: 189 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 248
+ C L + + V + P+ +V EP+ V G V L C+
Sbjct: 3001 AGRYQC-----LAENEMGVAKKVVILVLQSAPVFQV----EPQDMTVRSGDDVALRCQAT 3051
Query: 249 AQPSPQIHWMK 259
+P+P I W++
Sbjct: 3052 GEPTPTIEWLQ 3062
Score = 47.4 bits (111), Expect = 2e-05
Identities = 54/199 (27%), Positives = 84/199 (42%), Gaps = 38/199 (19%)
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIP------GKPEIVDSASELTAGVPNKVGTCVS 132
D G++ C+A N G K+ R+ VY P G+P +V + AG P + CV+
Sbjct: 285 DAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAV----AGRPVAL-ECVA 338
Query: 133 EGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTF 192
G +P+ TLSWH +G P V+ ++R + + L+S G +
Sbjct: 339 RG-HPSPTLSWHHEGLP-------VAESNESRLETDGSVLRLESP-------GEASSGLY 383
Query: 193 SCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP--GGTVTLTCEVPAQ 250
SC S P A+ ++ +V QL+V G V G + L C+
Sbjct: 384 SCVASS--PAGEAVLQYSVEVQV-------PPQLLVAEGLGQVTTIVGQPLELPCQASGS 434
Query: 251 PSPQIHWMKDVSDLERGAG 269
P P I W+++ E AG
Sbjct: 435 PVPTIQWLQNGRPAEELAG 453
Score = 47.4 bits (111), Expect = 2e-05
Identities = 68/237 (28%), Positives = 94/237 (39%), Gaps = 38/237 (16%)
Query: 32 EPLVLKCKGAPKKPPQRLEWKLGGGPWDS-----VARVLPNGSLFLPAVGIQDEGIFRCQ 86
+P V + GA KPP W G W VA LP L + V ++DEGI+ C
Sbjct: 526 DPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPP-PLQIEKVDLRDEGIYTCA 584
Query: 87 AMNRNGKETKSNYRVRVYQIPG-KPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHL 145
A N G E+K ++V P +P V+ A A V + C++ G P +SW
Sbjct: 585 ATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLE---CLASG-VPPPDVSWFK 639
Query: 146 DGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFS--PGLPRH 203
+P V + GV+V R L + A+ D ++ C S G
Sbjct: 640 GHQP-VSSWMGVTVSVDGR------------VLRIEQAQLSDAG-SYRCVASNVAGSTEL 685
Query: 204 RALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
R + PR+ P L LV P V LTC PSP + W+KD
Sbjct: 686 RYGLRVNVPPRITLPPSLPGPVLVNTP----------VRLTCNATGAPSPTLMWLKD 732
Score = 47.0 bits (110), Expect = 2e-05
Identities = 57/252 (22%), Positives = 97/252 (38%), Gaps = 33/252 (13%)
Query: 45 PPQRLEWKLGGGPW---DSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRV 101
PP L W P D V+ + L +P V ++ G + C+A N G++ +Y +
Sbjct: 1496 PPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWL-HYEL 1554
Query: 102 RVYQIP---GKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVS 158
V P G E + E+T + V P T+SW +G P P+ +
Sbjct: 1555 LVLTPPVILGDTE--ELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQV 1612
Query: 159 VKE-QTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWE 217
+++ Q + + S + V + G F+ + PR+
Sbjct: 1613 LEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ-------------VPPRI-A 1658
Query: 218 PVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERGAGRTRRGGAN 277
+ LE+V ++ +V+L C+V A P+P++ W KD L G G +
Sbjct: 1659 GLDLEQVTAILN---------SSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH 1709
Query: 278 CRLCGRIRAGNS 289
GR R +S
Sbjct: 1710 TLQLGRARLSDS 1721
Score = 46.2 bits (108), Expect = 4e-05
Identities = 61/230 (26%), Positives = 92/230 (40%), Gaps = 31/230 (13%)
Query: 45 PPQRLEWKLGGGP---WDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRV 101
PP + W G P W V + L + + D G +RC A N G T+ Y +
Sbjct: 631 PPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS-TELRYGL 689
Query: 102 RVYQIPGKPEIVDSA-SELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVP-NEKGVSV 159
RV +P + + S + P ++ TC + G+ P+ TL W DG P+ P G+ V
Sbjct: 690 RV-NVPPRITLPPSLPGPVLVNTPVRL-TCNATGA-PSPTLMWLKDGNPVSPAGTPGLQV 746
Query: 160 KEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPV 219
P + TL S AR D +SC + R + +Q + +
Sbjct: 747 ------FPGGRVLTLAS------ARASDSG-RYSCVAVSAVGEDR--QDVVLQVHMPPSI 791
Query: 220 PLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERGAG 269
EE+ + +V +V L C+ A P P + W KD LE G
Sbjct: 792 LGEELNV-------SVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPG 834
Score = 45.8 bits (107), Expect = 6e-05
Identities = 31/93 (33%), Positives = 48/93 (51%), Gaps = 7/93 (7%)
Query: 21 VGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARV--LPNGSLFLPAVGIQ 78
V Q++T R G+ + L+C+ A +P +EW G P + R+ LP+GSL+L V
Sbjct: 3031 VEPQDMTVRSGDDVALRCQ-ATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG 3089
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPE 111
D G + C A N G T + V + G+P+
Sbjct: 3090 DAGTYDCVAHNLLGSATARAFLV----VRGEPQ 3118
Score = 45.4 bits (106), Expect = 7e-05
Identities = 63/251 (25%), Positives = 98/251 (39%), Gaps = 36/251 (14%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARV--LPNGS-LFLPAVGIQDEGI 82
+ R+G+ VL C+ P + W G P R L G L + + D+G+
Sbjct: 1760 VLVRVGDKAVLSCE-TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGL 1818
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNK--VGTCVSEGSYPAGT 140
+ C+ N G+ ++ + + V Q+P P + +E + V V TC G PA T
Sbjct: 1819 YSCKVSNVAGEAVRT-FTLTV-QVP--PTFENPKTETVSQVAGSPLVLTCDVSG-VPAPT 1873
Query: 141 LSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSC--SFSP 198
++W D P+ + +V R L LQ PA+ G T++C +
Sbjct: 1874 VTWLKDRMPV----ESSAVHGVVSRGGRLQLSRLQ------PAQAG----TYTCVAENTQ 1919
Query: 199 GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 258
R + + PR+ E V G V L CE QP P + W+
Sbjct: 1920 AEARKDFVVAVLVAPRIRSSGVAREHH---------VLEGQEVRLDCEADGQPPPDVAWL 1970
Query: 259 KDVSDLERGAG 269
KD S L + G
Sbjct: 1971 KDGSPLGQDMG 1981
Score = 45.4 bits (106), Expect = 7e-05
Identities = 65/256 (25%), Positives = 99/256 (38%), Gaps = 38/256 (14%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVA---RVLPNGSLFLPAVGIQ 78
G + + + +L C+ A P + W+ P D + +LP GSL + V Q
Sbjct: 2396 GPPAVNVSVNQTALLPCQ-ADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQ 2454
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE--LTAGVPNKVGTCVSEGSY 136
D G + C A N G + + R ++ P I S S LTA P + C + GS
Sbjct: 2455 DAGHYLCLASNSAGSDRQG----RDLRVLEPPAIAPSPSNLTLTAHTPALL-PCEASGS- 2508
Query: 137 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 196
P + W DG+ L R + L S ++ A G F C
Sbjct: 2509 PKPLVVWWKDGQKL------------DFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVV 2556
Query: 197 SPGL-PRHRALR-TAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQ 254
S + HR + T + P + + ++ V +AP V LTC P+P
Sbjct: 2557 SNEVGEAHRLYQVTVHVPPTIAD----DQTDFTVT----MMAP---VVLTCHSTGIPAPT 2605
Query: 255 IHWMKDVSDL-ERGAG 269
+ W K + L RG+G
Sbjct: 2606 VSWSKAGAQLGARGSG 2621
Score = 45.1 bits (105), Expect = 9e-05
Identities = 56/241 (23%), Positives = 89/241 (36%), Gaps = 38/241 (15%)
Query: 36 LKCKGAPKKPPQRLEWKLGGGPWDS-VARVLPNG--SLFLPAVGIQDEGIFRCQAMNRNG 92
L+C A KPP + W+ G P + + L N SL + G + C A N G
Sbjct: 996 LECN-ATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG 1054
Query: 93 KETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVP 152
+ + + + V P +D + +TA + + + P + W +P+ P
Sbjct: 1055 RAERK-FELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 1113
Query: 153 NEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRAL 206
E G +K + ++GL++ + G+ R FS
Sbjct: 1114 GEDTYLLAGGWMLKMTQTQEQDSGLYSC-----LASNEAGEARRNFSVEV---------- 1158
Query: 207 RTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLER 266
+ P E LEEV V++ G T L C V P P++ W KD L R
Sbjct: 1159 ----LVPPSIENEDLEEVIKVLD--------GQTAHLMCNVTGHPQPKLTWFKDGRPLAR 1206
Query: 267 G 267
G
Sbjct: 1207 G 1207
Score = 44.7 bits (104), Expect = 1e-04
Identities = 65/266 (24%), Positives = 98/266 (36%), Gaps = 65/266 (24%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEW----KLGGGP-----------WDSVA--RVLPN 67
N++ G+ L L+C A P + W +L G P W V R+L
Sbjct: 27 NVSGMAGQSLTLECD-ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE 85
Query: 68 G-SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNK 126
G SL P + D G++ C+A N+ G + + + ++ S L AG +
Sbjct: 86 GQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLL----------VLTPPSVLGAGAAQE 135
Query: 127 VG---------TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSE 177
V C + G P + W D +P++P + V+E +
Sbjct: 136 VLGLAGADVELQCWTSG-VPTPQVEWTKDRQPVLPGGPHLQVQEDGQ------------V 182
Query: 178 LMVTPARGGDPRPTFSCSFSPGLPRHRALRT---APIQPRVWEPVPLEEVQLVVEPEGGA 234
L +T + GD +FSP + R + AP P +W EV A
Sbjct: 183 LRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP--PTIWGSNETGEV---------A 231
Query: 235 VAPGGTVTLTCEVPAQPSPQIHWMKD 260
V V L CE P+P I W KD
Sbjct: 232 VMEDHLVQLLCEARGVPTPNITWFKD 257
Score = 43.5 bits (101), Expect = 3e-04
Identities = 56/263 (21%), Positives = 100/263 (38%), Gaps = 36/263 (13%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARV-LPNGSLFLPAVGIQ--DE 80
+ +T + P+ L C+ A P + W G P+++ + L G+ L + Q D
Sbjct: 1267 EEVTVTVNNPISLICE-ALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDA 1325
Query: 81 GIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVS----EGSY 136
G + C N G+ K NY V V P + A V KV + ++ +
Sbjct: 1326 GQYTCVVTNELGEAVK-NYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAV 1384
Query: 137 PAGTLSWHLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRP 190
P T+ W+ DG+P+ P+ + G ++ Q + ++G + L V G+
Sbjct: 1385 PPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY-----LCVATNVAGEDDQ 1439
Query: 191 TFSCSFSPGLPRHRALRTAPIQPRVWE-PVPLEEVQLVVEPEGGA-----VAPGGTVTLT 244
F+ ++ P+ +V + E + E GG + L
Sbjct: 1440 DFNV----------LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1489
Query: 245 CEVPAQPSPQIHWMKDVSDLERG 267
C+ A P P + W ++ L G
Sbjct: 1490 CDTNAIPPPDLTWYREDQPLSAG 1512
Score = 40.0 bits (92), Expect = 0.003
Identities = 63/265 (23%), Positives = 101/265 (38%), Gaps = 47/265 (17%)
Query: 19 AVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR--VLPNGSLF-LPAV 75
A VG + + ++ L L+C+ + PP + W G P +R VL G L +
Sbjct: 1360 AEVGVKEVKTKVNSTLTLECE-SWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPT 1418
Query: 76 GIQDEGIFRCQAMNRNGKETKS-NYRVRVYQIPGKP-------EIVDSASELTAGVP--- 124
+ D G + C A N G++ + N ++V + K EI+ E GV
Sbjct: 1419 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 1478
Query: 125 -----NKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELM 179
N + P L+W+ + +PL ++ VSV + R LQ L+
Sbjct: 1479 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE-VSVLQGGR--------VLQIPLV 1529
Query: 180 VTPARGGDPRPTFSCSFSPGLP----RHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 235
G +SC S + + L P PV L + + +VE V
Sbjct: 1530 RAENAG-----RYSCKASNEVGEDWLHYELLVLTP-------PVILGDTEELVEEV--TV 1575
Query: 236 APGGTVTLTCEVPAQPSPQIHWMKD 260
TV+L C P P I W+++
Sbjct: 1576 NASSTVSLQCPALGNPVPTISWLQN 1600
Score = 39.3 bits (90), Expect = 0.005
Identities = 52/200 (26%), Positives = 80/200 (40%), Gaps = 37/200 (18%)
Query: 63 RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASEL-TA 121
+VLP G L + +D G + C A N G V Q+P P I + +L T
Sbjct: 2713 QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTR--LVVQVP--PVIENGLPDLSTT 2768
Query: 122 GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQ--SELM 179
+ C + GS P ++W DG+P+ E G FT+Q EL+
Sbjct: 2769 EGSHAFLPCKARGS-PEPNITWDKDGQPVSGAE---------------GKFTIQPSGELL 2812
Query: 180 VTPARGGDPRPTFSCSF--SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP 237
V G D T++C+ + G R R T + P V+ +P + ++
Sbjct: 2813 VKNLEGQD-AGTYTCTAENAVGRARRRVHLTILVLP-VFTTLPGDR----------SLRL 2860
Query: 238 GGTVTLTCEVPAQPSPQIHW 257
G + L C P+P+I W
Sbjct: 2861 GDRLWLRCAARGSPTPRIGW 2880
Score = 38.9 bits (89), Expect = 0.007
Identities = 24/74 (32%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVA--RVLPNGS-LFLPAVGIQ 78
G +T +G+PL L C+ A P ++W G P + +A +V G+ L + V +
Sbjct: 413 GLGQVTTIVGQPLELPCQ-ASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELD 471
Query: 79 DEGIFRCQAMNRNG 92
G+F CQA N G
Sbjct: 472 HSGLFACQATNEAG 485
Score = 28.9 bits (63), Expect = 7.0
Identities = 22/86 (25%), Positives = 32/86 (37%), Gaps = 4/86 (4%)
Query: 65 LPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVP 124
L NGSL + D G ++C A N G K V + + P ++T
Sbjct: 2986 LQNGSLTIRRTERDDAGRYQCLAENEMGVAKK----VVILVLQSAPVFQVEPQDMTVRSG 3041
Query: 125 NKVGTCVSEGSYPAGTLSWHLDGKPL 150
+ V P T+ W G+PL
Sbjct: 3042 DDVALRCQATGEPTPTIEWLQAGQPL 3067
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 63.9 bits (154), Expect = 2e-10
Identities = 63/248 (25%), Positives = 91/248 (36%), Gaps = 37/248 (14%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWD-------SVARVLPNGSLFLPAV-----GIQ 78
GEP L CK A +P +EW GG + S +LP+GSLF +
Sbjct: 43 GEPATLNCK-AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 101
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 138
DEG++ C A N G+ N + V + S + G P V C +P
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP-AVMECQPPRGHPE 160
Query: 139 GTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSP 198
T+SW DG PL ++ ++++ +LM+T R D +
Sbjct: 161 PTISWKKDGSPLDDKDERITIRG--------------GKLMITYTRKSDAGKYVCVGTNM 206
Query: 199 GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 258
R + V E LE V P AV + CE P P + W
Sbjct: 207 VGER---------ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 259 KDVSDLER 266
KD +L +
Sbjct: 258 KDDGELPK 265
Score = 59.3 bits (142), Expect = 5e-09
Identities = 58/241 (24%), Positives = 87/241 (36%), Gaps = 29/241 (12%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR--VLPNGSLFLPAVGIQDEGI 82
++ +GEP V++C+ P + WK G P D + G L + D G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TCVSEGSYPAGTL 141
+ C N G+ + V + +P V S L V + C + G P T+
Sbjct: 199 YVCVGTNMVGERESEVAELTVLE---RPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTV 254
Query: 142 SWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLP 201
W D L + + R T L + GD +++C +
Sbjct: 255 RWRKDDGELPKSRYEI-------RDDHT--------LKIRKVTAGD-MGSYTCVAENMVG 298
Query: 202 RHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDV 261
+ A T +Q V E VV+P VA G TVT CE P P I W ++
Sbjct: 299 KAEASATLTVQ------VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Query: 262 S 262
S
Sbjct: 353 S 353
Score = 33.9 bits (76), Expect = 0.22
Identities = 36/126 (28%), Positives = 53/126 (42%), Gaps = 8/126 (6%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGG---GPWDSVARVLPNGSLFLPAVGIQ 78
G N T + VL C A P + W+ G DS + L NG L + +
Sbjct: 424 GPVNQTVAVDGTFVLSCV-ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 79 DEGIFRCQAMNRNGKETKSNY-RVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYP 137
D G + C A +G+ T S Y V+ + +P +P + L P+K V++ S
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP-RPTDPNLIPSAPSKPE--VTDVSRN 539
Query: 138 AGTLSW 143
TLSW
Sbjct: 540 TVTLSW 545
Score = 29.6 bits (65), Expect = 4.1
Identities = 12/35 (34%), Positives = 18/35 (51%)
Query: 225 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMK 259
++V P V+ G TL C+ +P+P I W K
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK 64
Score = 28.5 bits (62), Expect = 9.1
Identities = 13/31 (41%), Positives = 14/31 (45%)
Query: 230 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
P VA GT L+C P P I W KD
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTILWRKD 455
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 63.9 bits (154), Expect = 2e-10
Identities = 63/248 (25%), Positives = 91/248 (36%), Gaps = 37/248 (14%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWD-------SVARVLPNGSLFLPAV-----GIQ 78
GEP L CK A +P +EW GG + S +LP+GSLF +
Sbjct: 43 GEPATLNCK-AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 101
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 138
DEG++ C A N G+ N + V + S + G P V C +P
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP-AVMECQPPRGHPE 160
Query: 139 GTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSP 198
T+SW DG PL ++ ++++ +LM+T R D +
Sbjct: 161 PTISWKKDGSPLDDKDERITIRG--------------GKLMITYTRKSDAGKYVCVGTNM 206
Query: 199 GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 258
R + V E LE V P AV + CE P P + W
Sbjct: 207 VGER---------ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 259 KDVSDLER 266
KD +L +
Sbjct: 258 KDDGELPK 265
Score = 59.3 bits (142), Expect = 5e-09
Identities = 58/241 (24%), Positives = 87/241 (36%), Gaps = 29/241 (12%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR--VLPNGSLFLPAVGIQDEGI 82
++ +GEP V++C+ P + WK G P D + G L + D G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TCVSEGSYPAGTL 141
+ C N G+ + V + +P V S L V + C + G P T+
Sbjct: 199 YVCVGTNMVGERESEVAELTVLE---RPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTV 254
Query: 142 SWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLP 201
W D L + + R T L + GD +++C +
Sbjct: 255 RWRKDDGELPKSRYEI-------RDDHT--------LKIRKVTAGD-MGSYTCVAENMVG 298
Query: 202 RHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDV 261
+ A T +Q V E VV+P VA G TVT CE P P I W ++
Sbjct: 299 KAEASATLTVQ------VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Query: 262 S 262
S
Sbjct: 353 S 353
Score = 33.9 bits (76), Expect = 0.22
Identities = 36/126 (28%), Positives = 53/126 (42%), Gaps = 8/126 (6%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGG---GPWDSVARVLPNGSLFLPAVGIQ 78
G N T + VL C A P + W+ G DS + L NG L + +
Sbjct: 424 GPVNQTVAVDGTFVLSCV-ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 79 DEGIFRCQAMNRNGKETKSNY-RVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYP 137
D G + C A +G+ T S Y V+ + +P +P + L P+K V++ S
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP-RPTDPNLIPSAPSKPE--VTDVSRN 539
Query: 138 AGTLSW 143
TLSW
Sbjct: 540 TVTLSW 545
Score = 29.6 bits (65), Expect = 4.1
Identities = 12/35 (34%), Positives = 18/35 (51%)
Query: 225 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMK 259
++V P V+ G TL C+ +P+P I W K
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK 64
Score = 28.5 bits (62), Expect = 9.1
Identities = 13/31 (41%), Positives = 14/31 (45%)
Query: 230 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
P VA GT L+C P P I W KD
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTILWRKD 455
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 63.9 bits (154), Expect = 2e-10
Identities = 63/248 (25%), Positives = 91/248 (36%), Gaps = 37/248 (14%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWD-------SVARVLPNGSLFLPAV-----GIQ 78
GEP L CK A +P +EW GG + S +LP+GSLF +
Sbjct: 43 GEPATLNCK-AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 101
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 138
DEG++ C A N G+ N + V + S + G P V C +P
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP-AVMECQPPRGHPE 160
Query: 139 GTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSP 198
T+SW DG PL ++ ++++ +LM+T R D +
Sbjct: 161 PTISWKKDGSPLDDKDERITIRG--------------GKLMITYTRKSDAGKYVCVGTNM 206
Query: 199 GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 258
R + V E LE V P AV + CE P P + W
Sbjct: 207 VGER---------ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 259 KDVSDLER 266
KD +L +
Sbjct: 258 KDDGELPK 265
Score = 58.2 bits (139), Expect = 1e-08
Identities = 57/241 (23%), Positives = 86/241 (35%), Gaps = 32/241 (13%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR--VLPNGSLFLPAVGIQDEGI 82
++ +GEP V++C+ P + WK G P D + G L + D G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TCVSEGSYPAGTL 141
+ C N G+ + V + +P V S L V + C + G P T+
Sbjct: 199 YVCVGTNMVGERESEVAELTVLE---RPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTV 254
Query: 142 SWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLP 201
W D L + + R T L + GD +++C +
Sbjct: 255 RWRKDDGELPKSRYEI-------RDDHT--------LKIRKVTAGD-MGSYTCVAENMVG 298
Query: 202 RHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDV 261
+ A T +Q E VV+P VA G TVT CE P P I W ++
Sbjct: 299 KAEASATLTVQ---------EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 349
Query: 262 S 262
S
Sbjct: 350 S 350
Score = 33.9 bits (76), Expect = 0.22
Identities = 36/126 (28%), Positives = 53/126 (42%), Gaps = 8/126 (6%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGG---GPWDSVARVLPNGSLFLPAVGIQ 78
G N T + VL C A P + W+ G DS + L NG L + +
Sbjct: 421 GPVNQTVAVDGTFVLSCV-ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 479
Query: 79 DEGIFRCQAMNRNGKETKSNY-RVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYP 137
D G + C A +G+ T S Y V+ + +P +P + L P+K V++ S
Sbjct: 480 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP-RPTDPNLIPSAPSKPE--VTDVSRN 536
Query: 138 AGTLSW 143
TLSW
Sbjct: 537 TVTLSW 542
Score = 29.6 bits (65), Expect = 4.1
Identities = 12/35 (34%), Positives = 18/35 (51%)
Query: 225 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMK 259
++V P V+ G TL C+ +P+P I W K
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK 64
Score = 28.5 bits (62), Expect = 9.1
Identities = 13/31 (41%), Positives = 14/31 (45%)
Query: 230 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
P VA GT L+C P P I W KD
Sbjct: 422 PVNQTVAVDGTFVLSCVATGSPVPTILWRKD 452
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 63.9 bits (154), Expect = 2e-10
Identities = 63/248 (25%), Positives = 91/248 (36%), Gaps = 37/248 (14%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWD-------SVARVLPNGSLFLPAV-----GIQ 78
GEP L CK A +P +EW GG + S +LP+GSLF +
Sbjct: 43 GEPATLNCK-AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 101
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 138
DEG++ C A N G+ N + V + S + G P V C +P
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP-AVMECQPPRGHPE 160
Query: 139 GTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSP 198
T+SW DG PL ++ ++++ +LM+T R D +
Sbjct: 161 PTISWKKDGSPLDDKDERITIRG--------------GKLMITYTRKSDAGKYVCVGTNM 206
Query: 199 GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 258
R + V E LE V P AV + CE P P + W
Sbjct: 207 VGER---------ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 259 KDVSDLER 266
KD +L +
Sbjct: 258 KDDGELPK 265
Score = 59.3 bits (142), Expect = 5e-09
Identities = 58/241 (24%), Positives = 87/241 (36%), Gaps = 29/241 (12%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR--VLPNGSLFLPAVGIQDEGI 82
++ +GEP V++C+ P + WK G P D + G L + D G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TCVSEGSYPAGTL 141
+ C N G+ + V + +P V S L V + C + G P T+
Sbjct: 199 YVCVGTNMVGERESEVAELTVLE---RPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTV 254
Query: 142 SWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLP 201
W D L + + R T L + GD +++C +
Sbjct: 255 RWRKDDGELPKSRYEI-------RDDHT--------LKIRKVTAGD-MGSYTCVAENMVG 298
Query: 202 RHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDV 261
+ A T +Q V E VV+P VA G TVT CE P P I W ++
Sbjct: 299 KAEASATLTVQ------VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Query: 262 S 262
S
Sbjct: 353 S 353
Score = 33.9 bits (76), Expect = 0.22
Identities = 36/126 (28%), Positives = 53/126 (42%), Gaps = 8/126 (6%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGG---GPWDSVARVLPNGSLFLPAVGIQ 78
G N T + VL C A P + W+ G DS + L NG L + +
Sbjct: 424 GPVNQTVAVDGTFVLSCV-ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 79 DEGIFRCQAMNRNGKETKSNY-RVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYP 137
D G + C A +G+ T S Y V+ + +P +P + L P+K V++ S
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP-RPTDPNLIPSAPSKPE--VTDVSRN 539
Query: 138 AGTLSW 143
TLSW
Sbjct: 540 TVTLSW 545
Score = 29.6 bits (65), Expect = 4.1
Identities = 12/35 (34%), Positives = 18/35 (51%)
Query: 225 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMK 259
++V P V+ G TL C+ +P+P I W K
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK 64
Score = 28.5 bits (62), Expect = 9.1
Identities = 13/31 (41%), Positives = 14/31 (45%)
Query: 230 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
P VA GT L+C P P I W KD
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTILWRKD 455
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 63.9 bits (154), Expect = 2e-10
Identities = 63/248 (25%), Positives = 91/248 (36%), Gaps = 37/248 (14%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWD-------SVARVLPNGSLFLPAV-----GIQ 78
GEP L CK A +P +EW GG + S +LP+GSLF +
Sbjct: 43 GEPATLNCK-AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 101
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 138
DEG++ C A N G+ N + V + S + G P V C +P
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP-AVMECQPPRGHPE 160
Query: 139 GTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSP 198
T+SW DG PL ++ ++++ +LM+T R D +
Sbjct: 161 PTISWKKDGSPLDDKDERITIRG--------------GKLMITYTRKSDAGKYVCVGTNM 206
Query: 199 GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 258
R + V E LE V P AV + CE P P + W
Sbjct: 207 VGER---------ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 259 KDVSDLER 266
KD +L +
Sbjct: 258 KDDGELPK 265
Score = 59.3 bits (142), Expect = 5e-09
Identities = 58/241 (24%), Positives = 87/241 (36%), Gaps = 29/241 (12%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR--VLPNGSLFLPAVGIQDEGI 82
++ +GEP V++C+ P + WK G P D + G L + D G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TCVSEGSYPAGTL 141
+ C N G+ + V + +P V S L V + C + G P T+
Sbjct: 199 YVCVGTNMVGERESEVAELTVLE---RPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTV 254
Query: 142 SWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLP 201
W D L + + R T L + GD +++C +
Sbjct: 255 RWRKDDGELPKSRYEI-------RDDHT--------LKIRKVTAGD-MGSYTCVAENMVG 298
Query: 202 RHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDV 261
+ A T +Q V E VV+P VA G TVT CE P P I W ++
Sbjct: 299 KAEASATLTVQ------VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Query: 262 S 262
S
Sbjct: 353 S 353
Score = 33.9 bits (76), Expect = 0.22
Identities = 36/126 (28%), Positives = 53/126 (42%), Gaps = 8/126 (6%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGG---GPWDSVARVLPNGSLFLPAVGIQ 78
G N T + VL C A P + W+ G DS + L NG L + +
Sbjct: 424 GPVNQTVAVDGTFVLSCV-ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 79 DEGIFRCQAMNRNGKETKSNY-RVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYP 137
D G + C A +G+ T S Y V+ + +P +P + L P+K V++ S
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP-RPTDPNLIPSAPSKPE--VTDVSRN 539
Query: 138 AGTLSW 143
TLSW
Sbjct: 540 TVTLSW 545
Score = 29.6 bits (65), Expect = 4.1
Identities = 12/35 (34%), Positives = 18/35 (51%)
Query: 225 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMK 259
++V P V+ G TL C+ +P+P I W K
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK 64
Score = 28.5 bits (62), Expect = 9.1
Identities = 13/31 (41%), Positives = 14/31 (45%)
Query: 230 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
P VA GT L+C P P I W KD
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTILWRKD 455
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 63.9 bits (154), Expect = 2e-10
Identities = 63/248 (25%), Positives = 91/248 (36%), Gaps = 37/248 (14%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWD-------SVARVLPNGSLFLPAV-----GIQ 78
GEP L CK A +P +EW GG + S +LP+GSLF +
Sbjct: 82 GEPATLNCK-AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 140
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 138
DEG++ C A N G+ N + V + S + G P V C +P
Sbjct: 141 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP-AVMECQPPRGHPE 199
Query: 139 GTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSP 198
T+SW DG PL ++ ++++ +LM+T R D +
Sbjct: 200 PTISWKKDGSPLDDKDERITIRG--------------GKLMITYTRKSDAGKYVCVGTNM 245
Query: 199 GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 258
R + V E LE V P AV + CE P P + W
Sbjct: 246 VGER---------ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
Query: 259 KDVSDLER 266
KD +L +
Sbjct: 297 KDDGELPK 304
Score = 58.2 bits (139), Expect = 1e-08
Identities = 57/241 (23%), Positives = 86/241 (35%), Gaps = 32/241 (13%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR--VLPNGSLFLPAVGIQDEGI 82
++ +GEP V++C+ P + WK G P D + G L + D G
Sbjct: 178 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 237
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TCVSEGSYPAGTL 141
+ C N G+ + V + +P V S L V + C + G P T+
Sbjct: 238 YVCVGTNMVGERESEVAELTVLE---RPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTV 293
Query: 142 SWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLP 201
W D L + + R T L + GD +++C +
Sbjct: 294 RWRKDDGELPKSRYEI-------RDDHT--------LKIRKVTAGD-MGSYTCVAENMVG 337
Query: 202 RHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDV 261
+ A T +Q E VV+P VA G TVT CE P P I W ++
Sbjct: 338 KAEASATLTVQ---------EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 388
Query: 262 S 262
S
Sbjct: 389 S 389
Score = 33.9 bits (76), Expect = 0.22
Identities = 36/126 (28%), Positives = 53/126 (42%), Gaps = 8/126 (6%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGG---GPWDSVARVLPNGSLFLPAVGIQ 78
G N T + VL C A P + W+ G DS + L NG L + +
Sbjct: 460 GPVNQTVAVDGTFVLSCV-ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 518
Query: 79 DEGIFRCQAMNRNGKETKSNY-RVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYP 137
D G + C A +G+ T S Y V+ + +P +P + L P+K V++ S
Sbjct: 519 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP-RPTDPNLIPSAPSKPE--VTDVSRN 575
Query: 138 AGTLSW 143
TLSW
Sbjct: 576 TVTLSW 581
Score = 29.6 bits (65), Expect = 4.1
Identities = 12/35 (34%), Positives = 18/35 (51%)
Query: 225 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMK 259
++V P V+ G TL C+ +P+P I W K
Sbjct: 69 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK 103
Score = 28.5 bits (62), Expect = 9.1
Identities = 13/31 (41%), Positives = 14/31 (45%)
Query: 230 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
P VA GT L+C P P I W KD
Sbjct: 461 PVNQTVAVDGTFVLSCVATGSPVPTILWRKD 491
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 61.6 bits (148), Expect = 1e-09
Identities = 66/277 (23%), Positives = 102/277 (36%), Gaps = 50/277 (18%)
Query: 15 SLWGAVVGAQNITARI-----------GEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR 63
SL G+ VG ++ RI GEP L C+ A +P +EW G +V
Sbjct: 51 SLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCR-AEGRPRPNIEWYKNGARVATVRE 109
Query: 64 -------VLPNGSLFLPAV-----GIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPE 111
+LP+G+LF P + DEG++ C A N G N + V + + +
Sbjct: 110 DPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVL--RDD 167
Query: 112 IVDSASELTAGVPNK-VGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETG 170
S + V V CV +P ++SW DG L E ++++
Sbjct: 168 FRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRG--------- 218
Query: 171 LFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEP 230
+LM++ D + + R A E + LE + P
Sbjct: 219 -----GKLMMSHTLKSDAGMYVCVASNMAGERESAAA---------EVMVLERPSFLRRP 264
Query: 231 EGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERG 267
V VT CEV P P++ W K+ +L G
Sbjct: 265 VNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTG 301
Score = 50.1 bits (118), Expect = 3e-06
Identities = 53/243 (21%), Positives = 89/243 (36%), Gaps = 32/243 (13%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPW-DSVARV-LPNGSLFLPAVGIQDEGI 82
N+ +GEP VL+C P + W+ G + R+ + G L + D G+
Sbjct: 174 NVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGM 233
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLS 142
+ C A N G+ + V V + P + +++ C +G P L
Sbjct: 234 YVCVASNMAGERESAAAEVMVLERPSF--LRRPVNQVVLADAPVTFLCEVKGD-PPPRLR 290
Query: 143 WHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPAR-GGDPRPTFSCSFSPGLP 201
W + L TG + ++S+ + + T++C +
Sbjct: 291 WRKEDGEL-----------------PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVG 333
Query: 202 RHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDV 261
R A + + VP QLV +P+ APG +V CE P P I W K+
Sbjct: 334 RAEASGSLSVH------VP---PQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEG 384
Query: 262 SDL 264
S +
Sbjct: 385 SQV 387
Score = 43.9 bits (102), Expect = 2e-04
Identities = 53/223 (23%), Positives = 87/223 (39%), Gaps = 27/223 (12%)
Query: 45 PPQRLEWKLGGGPWDSVA-RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGK-ETKSNYRVR 102
PP RL W+ G + + + SL++ V +DEG + C A N G+ E + V
Sbjct: 285 PPPRLRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVH 344
Query: 103 VYQIPGKPEIVDSASELTAGVPNKVG-TCVSEGSYPAGTLSWHLDGKP--LVPNEKGVSV 159
V P++V + A V C ++G+ P + W +G L P++
Sbjct: 345 V-----PPQLVTQPQDQMAAPGESVAFQCETKGN-PPPAIFWQKEGSQVLLFPSQS---- 394
Query: 160 KEQTRRHPETGLFTL--QSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWE 217
TG F++ + +L +T + GD + C A I+ +
Sbjct: 395 ------LQPTGRFSVSPRGQLNITAVQRGDAG-YYVCQAVSVAGSILAKALLEIKGASLD 447
Query: 218 PVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
+P +Q P + G +V L C V P P + W KD
Sbjct: 448 GLPPVILQ---GPANQTLVLGSSVWLPCRVTGNPQPSVRWKKD 487
Score = 33.9 bits (76), Expect = 0.22
Identities = 23/82 (28%), Positives = 36/82 (43%), Gaps = 6/82 (7%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPW----DSVARVLPNGSLFLPAVGI 77
G N T +G + L C+ P + WK G W D + + NG+L++ V
Sbjct: 456 GPANQTLVLGSSVWLPCR-VTGNPQPSVRWKKDG-QWLQGDDLQFKTMANGTLYIANVQE 513
Query: 78 QDEGIFRCQAMNRNGKETKSNY 99
D G + C A + G+ T S +
Sbjct: 514 MDMGFYSCVAKSSTGEATWSGW 535
Score = 30.4 bits (67), Expect = 2.4
Identities = 19/48 (39%), Positives = 22/48 (45%), Gaps = 2/48 (4%)
Query: 230 PEGGAVAPGGTVTLTCEVP-AQPSPQIHWMKDVSDLERGAGR-TRRGG 275
P VA G L C P P P + W KD + L+ GR T RGG
Sbjct: 172 PGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGG 219
>gi|24111244 MAM domain containing glycosylphosphatidylinositol
anchor 1 [Homo sapiens]
Length = 955
Score = 57.8 bits (138), Expect = 1e-08
Identities = 57/245 (23%), Positives = 91/245 (37%), Gaps = 24/245 (9%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGIF 83
+ + GE + ++C P +L+W G GP + + G+L +P+V +D G +
Sbjct: 248 ETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP-LGALAQGGTLSIPSVQARDSGYY 306
Query: 84 RCQAMNRNGKETKSNYRVRVYQIPG-----KPEIVDSASELTAGVPNKVGTCVSEGSYPA 138
C A N G K + V + P+++ + + G K+ V
Sbjct: 307 NCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEK 366
Query: 139 GTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFS- 197
T W +GKP +++ + TR PE T EL+ T+ C S
Sbjct: 367 VTYQWFKNGKPARMSKRLL----VTRNDPELPAVTSSLELIDLHF---SDYGTYLCMASF 419
Query: 198 PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVA---PGGTVTLTCEVPAQPSPQ 254
PG P I P + P+G AV G L CEV +P P
Sbjct: 420 PGAPVPDLSVEVNISSETVPPT-------ISVPKGRAVVTVREGSPAELQCEVRGKPRPP 472
Query: 255 IHWMK 259
+ W +
Sbjct: 473 VLWSR 477
Score = 35.0 bits (79), Expect = 0.097
Identities = 34/138 (24%), Positives = 53/138 (38%), Gaps = 7/138 (5%)
Query: 22 GAQNITARIGEPLVLKC--KGAPKKPP--QRLEWKLGGGPWDSVARVLPNGSLFLPAVGI 77
G +T R G P L+C +G P+ P R++ + P P+G L L V
Sbjct: 447 GRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSR 506
Query: 78 QDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASEL--TAGVPNKVGTCVSEGS 135
G +RCQ NG + + PE+ S+ ++ G P + + GS
Sbjct: 507 DMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGS 566
Query: 136 -YPAGTLSWHLDGKPLVP 152
+ W G+ L P
Sbjct: 567 PQRIASAVWRFKGQLLPP 584
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 56.2 bits (134), Expect = 4e-08
Identities = 63/237 (26%), Positives = 96/237 (40%), Gaps = 32/237 (13%)
Query: 30 IGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVL--PNGSLF-LPAVGIQDEGIFRCQ 86
I P+ L C+ PP L W G P S +VL P G + +P ++D G + C
Sbjct: 2791 INNPISLYCE-TNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCV 2849
Query: 87 AMNRNGKETKSNYRVRVYQIP-GKPEIVDSASELTAGV-PNKVGTCVSEGSYPAGTLSWH 144
A+N G E Y VRV P K D E+T V + + C+S GS PA SW
Sbjct: 2850 AVNEAG-EDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGS-PAPRNSWQ 2907
Query: 145 LDGKPLVPNEKGVSVKE-QTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRH 203
DG+PL+ ++ + + + T + + + V G + F+ +
Sbjct: 2908 KDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLN-------- 2959
Query: 204 RALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
+ P V P + E V ++LTCEV P P + W+K+
Sbjct: 2960 -----VHVPPSVIGP----------KSENLTVVVNNFISLTCEVSGFPPPDLSWLKN 3001
Score = 55.8 bits (133), Expect = 5e-08
Identities = 60/251 (23%), Positives = 96/251 (38%), Gaps = 28/251 (11%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPW--DSVARVLPNGSLF-LPAVGIQDE 80
QN++ I + + L C+ + PP L W G P + N S+ + +QD
Sbjct: 2111 QNVSVLISQAVELLCQ-SDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDT 2169
Query: 81 GIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGT 140
G + C+A N GK T+ NY V ++ +P D ++LT N + P
Sbjct: 2170 GRYTCEATNVAGK-TEKNYNVNIW-VPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPN 2227
Query: 141 LSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFS--P 198
L W G P++ + G + + +L ++ A D +SC S
Sbjct: 2228 LIWKKKGSPVLTDSMG-----------RVRILSGGRQLQISIAEKSDAA-LYSCVASNVA 2275
Query: 199 GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 258
G + I+P + P V G +++L CEV P P + WM
Sbjct: 2276 GTAKKEYNLQVYIRPTITNSGS--------HPTEIIVTRGKSISLECEVQGIPPPTVTWM 2327
Query: 259 KDVSDLERGAG 269
KD L + G
Sbjct: 2328 KDGHPLIKAKG 2338
Score = 54.3 bits (129), Expect = 2e-07
Identities = 62/252 (24%), Positives = 106/252 (42%), Gaps = 35/252 (13%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVA--RVLPNGSLFLPAVGIQDE- 80
+++T + P L C+ A PP + W G P +S R+LP G L + Q++
Sbjct: 2583 EDVTVILNSPTSLVCE-AYSYPPATITWFKDGTPLESNRNIRILPGGRT-LQILNAQEDN 2640
Query: 81 -GIFRCQAMNRNGKETKSNYRVRVYQIP--GKPEIVD---SASELTAGVPNKVGTCVSEG 134
G + C A N G+ K +Y V+VY P K ++ S E+ V N +
Sbjct: 2641 AGRYSCVATNEAGEMIK-HYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAY 2699
Query: 135 SYPAGTLSWHLDGKPLVPNE------KGVSVKEQTRRHPETGLFTLQSELMVTPARGGDP 188
+ P+ +LSW+ DG+PL ++ G +++ + + +TG +T V G+
Sbjct: 2700 AIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTC-----VASNIAGED 2754
Query: 189 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 248
F + ++ P ++WE + + E V ++L CE
Sbjct: 2755 ELDFDVN----------IQVPPSFQKLWEIGNMLDTGR--NGEAKDVIINNPISLYCETN 2802
Query: 249 AQPSPQIHWMKD 260
A P P + W KD
Sbjct: 2803 AAPPPTLTWYKD 2814
Score = 52.0 bits (123), Expect = 8e-07
Identities = 69/278 (24%), Positives = 112/278 (40%), Gaps = 34/278 (12%)
Query: 2 AAGTAVGAWVLVLSLWGAVVGAQNITARI-GEPLVLKCKGAPKKPPQRLEWKLGGGPWDS 60
+AG + L + + ++ G+ N+ A + P+ L+C+ A P L W G P S
Sbjct: 1996 SAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECE-ARGIPAPSLTWLKDGSPVSS 2054
Query: 61 VA---RVLPNGSLF-LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSA 116
+ +VL G + L + I D G + C A+N G E + + +RVY +P P I+
Sbjct: 2055 FSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAG-EKQRDIDLRVY-VP--PNIMGEE 2110
Query: 117 SELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQS 176
++ + V + P TL+W DG PL+ + G+S+ E +S
Sbjct: 2111 QNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLL-KKPGLSISEN------------RS 2157
Query: 177 ELMVTPARGGDP-RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 235
L + A+ D R T + G + P + L ++ V
Sbjct: 2158 VLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQL---------TV 2208
Query: 236 APGGTVTLTCEVPAQPSPQIHWMKDVSD-LERGAGRTR 272
G ++L CE P P + W K S L GR R
Sbjct: 2209 IEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVR 2246
Score = 52.0 bits (123), Expect = 8e-07
Identities = 59/252 (23%), Positives = 104/252 (41%), Gaps = 30/252 (11%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPW-DSVAR--VLPNGSLFLPAVGIQ 78
G Q++ + + VL+C A P R+ W+ G + AR +L NG L + + +
Sbjct: 3718 GPQSLVILLNKSTVLECI-AEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVT 3776
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 138
D G + C A N G + + R+ + Q+ P I + +T V + P
Sbjct: 3777 DTGRYLCMATNAAGTDRR---RIDL-QVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPK 3832
Query: 139 GTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSP 198
+++W +G L ++ S + L + S ++++P+ D T+ C+ +
Sbjct: 3833 PSINWRKNGHLLNVDQNQNSYR----------LLSSGSLVIISPSV--DDTATYECTVTN 3880
Query: 199 GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 258
G + RT + +V + E +V AV +TC P P IHW
Sbjct: 3881 GAGDDK--RTVDLTVQVPPSIADEPTDFLVTKHAPAV-------ITCTASGVPFPSIHWT 3931
Query: 259 KD-VSDLERGAG 269
K+ + L RG G
Sbjct: 3932 KNGIRLLPRGDG 3943
Score = 48.9 bits (115), Expect = 7e-06
Identities = 56/239 (23%), Positives = 88/239 (36%), Gaps = 28/239 (11%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWDSV--ARVLPNGSLF-LPAVGIQDEGIFRCQA 87
G+ + L+C+ PP + W G P +L G + L + + D G + C A
Sbjct: 2307 GKSISLECE-VQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVA 2365
Query: 88 MNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDG 147
+N G T Y + V+ P S ++ N V P +++W DG
Sbjct: 2366 VNVAGM-TDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDG 2424
Query: 148 KPL-VPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRAL 206
P+ + N + + R +T + V G+ R F S
Sbjct: 2425 WPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVL--------- 2475
Query: 207 RTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLE 265
+ P + LE+V+ V +VTLTCEV P P+I W KD L+
Sbjct: 2476 ----VPPHIVGENTLEDVK---------VKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ 2521
Score = 48.5 bits (114), Expect = 8e-06
Identities = 38/152 (25%), Positives = 64/152 (42%), Gaps = 14/152 (9%)
Query: 16 LWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPW--DSVARVLPNG-SLFL 72
LWG + + + ++ L L+C+ A P L W G P D + NG +L +
Sbjct: 2674 LWGPGLSPKEVKIKVNNTLTLECE-AYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQI 2732
Query: 73 PAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAG---------V 123
I D G + C A N G E + ++ V + P ++ + + L G +
Sbjct: 2733 KEAQISDTGRYTCVASNIAG-EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVII 2791
Query: 124 PNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEK 155
N + + P TL+W+ DG PL ++K
Sbjct: 2792 NNPISLYCETNAAPPPTLTWYKDGHPLTSSDK 2823
Score = 47.0 bits (110), Expect = 2e-05
Identities = 62/250 (24%), Positives = 97/250 (38%), Gaps = 34/250 (13%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWK----LGGGPWDSVARVLPNGSLF-LPAVGIQD 79
N T + P+ L+CK A P +K L G + L G + + + I D
Sbjct: 1929 NETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGS---TSMTFLNRGQIIDIESAQISD 1985
Query: 80 EGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAG 139
GI++C A+N G T+ Y ++V+ P I S + + V N V PA
Sbjct: 1986 AGIYKCVAINSAGA-TELFYSLQVHVAPS---ISGSNNMVAVVVNNPVRLECEARGIPAP 2041
Query: 140 TLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPG 199
+L+W DG P+ G+ V R L +T A+ D + +
Sbjct: 2042 SLTWLKDGSPVSSFSNGLQVLSGGR------------ILALTSAQISDTGRYTCVAVNAA 2089
Query: 200 LPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMK 259
+ R I RV+ P ++ E + +V V L C+ A P P + W+K
Sbjct: 2090 GEKQR-----DIDLRVYVP-----PNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLK 2139
Query: 260 DVSDLERGAG 269
D L + G
Sbjct: 2140 DGHPLLKKPG 2149
Score = 43.5 bits (101), Expect = 3e-04
Identities = 58/251 (23%), Positives = 93/251 (37%), Gaps = 41/251 (16%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPW--DSVARVL-PNGSLFLPAVGIQ 78
G +++ ++G+ + + C A P + W GG D V P+G+L +
Sbjct: 1176 GPKHLKVQVGQRVDIPCN-AQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPS 1234
Query: 79 DEGIFRCQAMNRNGK-ETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT------CV 131
D GI+ C A N G ET+ V+ P + D +V C
Sbjct: 1235 DAGIYTCVATNIAGTDETEITLHVQE-----PPTVEDLEPPYNTTFQERVANQRIEFPCP 1289
Query: 132 SEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPT 191
++G+ P T+ W +G+ L E G+S+ E TL VTP G+
Sbjct: 1290 AKGT-PKPTIKWLHNGRELTGREPGISILEDG---------TLLVIASVTPYDNGE---- 1335
Query: 192 FSCSF--SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPA 249
+ C G + + P + + + V +++ L CEV
Sbjct: 1336 YICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQ---------LTNLFCEVEG 1386
Query: 250 QPSPQIHWMKD 260
PSP I W KD
Sbjct: 1387 TPSPIIMWYKD 1397
Score = 43.1 bits (100), Expect = 4e-04
Identities = 60/255 (23%), Positives = 99/255 (38%), Gaps = 26/255 (10%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSV-ARVLPNGS-LFLPAVGIQDEGIF 83
+ R G + L+C+ PP +K G +S +L +G L + + D G +
Sbjct: 3069 VNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQY 3128
Query: 84 RCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE-LTAGVPNKVGTCVSEGSYPAGTLS 142
C+A+N G++ K N+ + VY +P P I E + + N V P T++
Sbjct: 3129 VCRAINVAGRDDK-NFHLNVY-VP--PSIEGPEREVIVETISNPVTLTCDATGIPPPTIA 3184
Query: 143 WHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPR 202
W + N K + + E + + S+L + ++ D ++C S +
Sbjct: 3185 W-------LKNHKRIENSDSL----EVRILSGGSKLQIARSQHSD-SGNYTCIASNMEGK 3232
Query: 203 HRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVS 262
+ IQ VP V P +V G V L C P+P I W+KD
Sbjct: 3233 AQKYYFLSIQ------VP-PSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGK 3285
Query: 263 DLERGAGRTRRGGAN 277
+ G R AN
Sbjct: 3286 PIASGETERIRVSAN 3300
Score = 42.0 bits (97), Expect = 8e-04
Identities = 61/256 (23%), Positives = 99/256 (38%), Gaps = 27/256 (10%)
Query: 11 VLVLSLWGAVVGAQNITARI--GEPLVLKCKGAPKKPPQRLEWKLGGGPW--DSVARVLP 66
V V L ++G A + G+ L L C P W + V
Sbjct: 882 VTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRS 941
Query: 67 NGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNK 126
+GSL + V +QD G + C A N G K+ V V+ +P S + G+P
Sbjct: 942 DGSLHIERVQLQDGGEYTCVASNVAGTNNKTT-SVVVHVLPTIQHGQQILSTIE-GIPVT 999
Query: 127 VGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGG 186
+ C + G+ P ++ W G+ + + S S +V+P GG
Sbjct: 1000 L-PCKASGN-PKPSVIWSKKGELISTSSAKFSAGADG------------SLYVVSP--GG 1043
Query: 187 DPRPTFSCSFS--PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLT 244
+ + C+ + G + + T ++PRV+ + +P +V G VTL
Sbjct: 1044 EESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGD---QRGLSQDKPVEISVLAGEEVTLP 1100
Query: 245 CEVPAQPSPQIHWMKD 260
CEV + P P I W K+
Sbjct: 1101 CEVKSLPPPIITWAKE 1116
Score = 41.2 bits (95), Expect = 0.001
Identities = 61/249 (24%), Positives = 93/249 (37%), Gaps = 32/249 (12%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGP--WDSVARVLPNGSLF-LPAVGIQDE 80
+NI+ + L C+ A P + W G P + R+L G + L ++D
Sbjct: 2394 ENISVVEKNSVSLTCE-ASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDA 2452
Query: 81 GIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG---TCVSEGSYP 137
G + C N G+E K + + P IV + V K TC G+ P
Sbjct: 2453 GQYTCVVRNAAGEERK----IFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGN-P 2507
Query: 138 AGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSC-SF 196
++WH DG+PL +E H +G LQ + P G ++C +
Sbjct: 2508 VPEITWHKDGQPL---------QEDEAHHIISGGRFLQITNVQVPHTG-----RYTCLAS 2553
Query: 197 SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIH 256
SP + R+ V+ + V PE V +L CE + P I
Sbjct: 2554 SPAGHKSRSFSL-----NVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATIT 2608
Query: 257 WMKDVSDLE 265
W KD + LE
Sbjct: 2609 WFKDGTPLE 2617
Score = 41.2 bits (95), Expect = 0.001
Identities = 60/258 (23%), Positives = 98/258 (37%), Gaps = 47/258 (18%)
Query: 21 VGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPW--DSVARVLPNGSLF-LPAVGI 77
+G + IT G + C P + W G P D+ V +G + L
Sbjct: 3440 MGTEEITVLKGSSTSMACI-TDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAET 3498
Query: 78 QDEGIFRCQAMNRNGKETKSNYRVRVYQIP---GKPEIVDSASELTAGVPNKVG-TCVSE 133
+D G + C A N G+ +K ++ ++V + P G E E++ V N + TC++
Sbjct: 3499 EDSGKYTCIASNEAGEVSK-HFILKVLEPPHINGSEE----HEEISVIVNNPLELTCIAS 3553
Query: 134 GSYPAGTLSWHLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGD 187
G PA ++W DG+PL ++ G ++ T + +TG +T L +PA D
Sbjct: 3554 G-IPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTC---LASSPAGDDD 3609
Query: 188 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 247
P + EP V VTL C+
Sbjct: 3610 KEYLVRVHVPPNIAG------------------------TDEPRDITVLRNRQVTLECKS 3645
Query: 248 PAQPSPQIHWMKDVSDLE 265
A P P I W+++ L+
Sbjct: 3646 DAVPPPVITWLRNGERLQ 3663
Score = 40.4 bits (93), Expect = 0.002
Identities = 60/243 (24%), Positives = 100/243 (41%), Gaps = 32/243 (13%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPW--DSVARVLPNGSLF-LPAVGIQDE 80
+ +T + + +++C + P R W+ G P D + L NG + + I D
Sbjct: 2880 EEVTVLVNKSALIECLSSGSPAP-RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDI 2938
Query: 81 GIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE-LTAGVPNKVGTCVSEGSYPAG 139
G + C A N G K + + V+ +P P ++ SE LT V N + +P
Sbjct: 2939 GRYVCVAENTAGS-AKKYFNLNVH-VP--PSVIGPKSENLTVVVNNFISLTCEVSGFPPP 2994
Query: 140 TLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF--S 197
LSW + NE+ + + T P G TLQ + + GG+ ++C
Sbjct: 2995 DLSW-------LKNEQPIKLNTNTLIVP--GGRTLQI-IRAKVSDGGE----YTCIAINQ 3040
Query: 198 PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHW 257
G + + T + P + + E + +V V G +V+L CE A P P I W
Sbjct: 3041 AGESKKKFSLTVYVPPSIKDH-DSESLSVV------NVREGTSVSLECESNAVPPPVITW 3093
Query: 258 MKD 260
K+
Sbjct: 3094 YKN 3096
Score = 40.0 bits (92), Expect = 0.003
Identities = 52/235 (22%), Positives = 84/235 (35%), Gaps = 34/235 (14%)
Query: 30 IGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR---VLPNGSLFLPAVGIQDEGIFRCQ 86
+ P++L C+ A P + W+ G ++ R VLP+G L + +D G + C
Sbjct: 4001 LNNPILLPCE-ATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCV 4059
Query: 87 AMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLD 146
A N G ++ V Q+P P I E V + P ++WH D
Sbjct: 4060 AQNPAGTAL-GKIKLNV-QVP--PVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKD 4115
Query: 147 GKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDP-RPTFSCSFSPGLPRHRA 205
G+ +V S++++ L + + GD T + G
Sbjct: 4116 GRAIVE-----SIRQRV---------LSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTST 4161
Query: 206 LRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
T + PR+ E V A+ P C P+P I+W KD
Sbjct: 4162 KLTVHVPPRIRS----TEGHYTVNENSQAILP-------CVADGIPTPAINWKKD 4205
Score = 38.9 bits (89), Expect = 0.007
Identities = 48/241 (19%), Positives = 92/241 (38%), Gaps = 31/241 (12%)
Query: 26 ITARIGEPLVLKC--KGAPKKPPQRLEWKLGGGPW---DSVARVLPNGS-LFLPAVGIQD 79
++ + + L+C KG P + W G P D +L G L L D
Sbjct: 1463 VSVVLNRDVALECQVKGTPFPD---IHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRND 1519
Query: 80 EGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAG 139
+G ++C N GK+ K + ++ +Y IP + + ++++ + + + P
Sbjct: 1520 KGRYQCTVSNAAGKQAK-DIKLTIY-IPPSIKGGNVTTDISVLINSLIKLECETRGLPMP 1577
Query: 140 TLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPG 199
++W+ DG+P++ + + + + + H P T++C +
Sbjct: 1578 AITWYKDGQPIMSSSQALYIDKGQYLH--------------IPRAQVSDSATYTCHVA-- 1621
Query: 200 LPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMK 259
TA V VP + P V ++TL C+ PSP + W+K
Sbjct: 1622 ----NVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLK 1677
Query: 260 D 260
D
Sbjct: 1678 D 1678
Score = 38.9 bits (89), Expect = 0.007
Identities = 57/254 (22%), Positives = 103/254 (40%), Gaps = 36/254 (14%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPW-DSVARVLPNGSLFLPAVGIQ--DE 80
+++ + + + L C+ P+ + W G P + A + +G FL +Q
Sbjct: 2487 EDVKVKEKQSVTLTCEVTGNPVPE-ITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHT 2545
Query: 81 GIFRCQAMNRNGKETKSNYRVRVYQIPGKPEI-VDSASELTAGVPNKVGTCVSEG-SYPA 138
G + C A + G +++S + + V+ P + D E + N + V E SYP
Sbjct: 2546 GRYTCLASSPAGHKSRS-FSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPP 2604
Query: 139 GTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSC---S 195
T++W DG PL N + + + R L + A+ D +SC +
Sbjct: 2605 ATITWFKDGTPLESN-RNIRILPGGR------------TLQILNAQ-EDNAGRYSCVATN 2650
Query: 196 FSPGLPRHRALRT--API--QPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQP 251
+ + +H ++ PI + +W P + P+ + T+TL CE A P
Sbjct: 2651 EAGEMIKHYEVKVYIPPIINKGDLWGP--------GLSPKEVKIKVNNTLTLECEAYAIP 2702
Query: 252 SPQIHWMKDVSDLE 265
S + W KD L+
Sbjct: 2703 SASLSWYKDGQPLK 2716
Score = 38.1 bits (87), Expect = 0.011
Identities = 55/232 (23%), Positives = 83/232 (35%), Gaps = 33/232 (14%)
Query: 33 PLVLKCKGAPKKPPQRLEWKLGGG---PWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMN 89
P V+ C A P + W G P R+L +G++ + A + G + C A N
Sbjct: 3913 PAVITCT-ASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARN 3971
Query: 90 RNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKP 149
G S +R + P I SEL + N + P+ ++W
Sbjct: 3972 AAG----SAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQ----- 4022
Query: 150 LVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSC-SFSPGLPRHRALRT 208
++G++V R H LQ V G T+ C + +P ++
Sbjct: 4023 ----KEGINVNTSGRNHAVLPSGGLQISRAVREDAG-----TYMCVAQNPAGTALGKIKL 4073
Query: 209 APIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
P V P E V V +P +TL+CE P P I W KD
Sbjct: 4074 NVQVPPVISPHLKEYVIAVDKP----------ITLSCEADGLPPPDITWHKD 4115
Score = 37.7 bits (86), Expect = 0.015
Identities = 51/248 (20%), Positives = 87/248 (35%), Gaps = 42/248 (16%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSV----ARVLPNGS-LFLPAVGIQDE 80
I I P+ L C A PP + W ++ R+L GS L + D
Sbjct: 3161 IVETISNPVTLTCD-ATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDS 3219
Query: 81 GIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGT 140
G + C A N GK K Y Q+P + S+++ + V + P
Sbjct: 3220 GNYTCIASNMEGKAQK--YYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPL 3277
Query: 141 LSWHLDGKPLVPNE--------KGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTF 192
+ W DGKP+ E G ++ +TG +T + PA D
Sbjct: 3278 IQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTC---VATNPAGEEDRIFNL 3334
Query: 193 SCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPS 252
+ +P + ++ E++ +V+ ++ + C P
Sbjct: 3335 NVYVTPTIRGNKD--------------EAEKLMTLVDT---------SINIECRATGTPP 3371
Query: 253 PQIHWMKD 260
PQI+W+K+
Sbjct: 3372 PQINWLKN 3379
Score = 37.4 bits (85), Expect = 0.020
Identities = 54/221 (24%), Positives = 85/221 (38%), Gaps = 30/221 (13%)
Query: 45 PPQRLEWKLGGGPWDSVA--RVLPNG-SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRV 101
PP + W G D ++L NG L + + + G++RC A N G + K + V
Sbjct: 1762 PPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAG-DHKKEFEV 1820
Query: 102 RVYQIPGKPEIVDSASELTAGVPNK--VGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSV 159
V+ +P P I S V K C++ G P +++W D +P+ + + +
Sbjct: 1821 TVH-VP--PTIKSSGLSERVVVKYKPVALQCIANG-IPNPSITWLKDDQPVNTAQGNLKI 1876
Query: 160 KEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPV 219
+ R LQ + G R T + + G + IQ V EP
Sbjct: 1877 QSSGR--------VLQIAKTLLEDAG---RYTCVATNAAGETQQH------IQLHVHEPP 1919
Query: 220 PLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
LE+ ++ V V L C+ P P I W KD
Sbjct: 1920 SLEDAGKMLNE---TVLVSNPVQLECKAAGNPVPVITWYKD 1957
Score = 36.2 bits (82), Expect = 0.044
Identities = 48/219 (21%), Positives = 84/219 (38%), Gaps = 28/219 (12%)
Query: 66 PNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPN 125
P G L L V ++D G + C A N G++T + + V+ +P E+ S L G
Sbjct: 4220 PYGELILENVVLEDSGFYTCVANNAAGEDTHT-VSLTVHVLPTFTELPGDVS-LNKGEQL 4277
Query: 126 KVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARG 185
++ +C + G P L+W + + + V+ SEL++
Sbjct: 4278 RL-SCKATG-IPLPKLTWTFNNNIIPAHFDSVNG---------------HSELVIERVSK 4320
Query: 186 GDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTC 245
D T+ C+ + +A+ ++ EP + P GG L C
Sbjct: 4321 EDSG-TYVCTAENSVGFVKAIGFVYVK----EPPVFKGDY----PSNWIEPLGGNAILNC 4371
Query: 246 EVPAQPSPQIHWMKDVSDLERGAGRTRRGGANCRLCGRI 284
EV P+P I W + D+E + G + + G +
Sbjct: 4372 EVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTV 4410
Score = 35.8 bits (81), Expect = 0.057
Identities = 51/208 (24%), Positives = 78/208 (37%), Gaps = 30/208 (14%)
Query: 64 VLPNGSLFLPA-VGIQDEGIFRCQAMNRNGK-ETKSNYRVRVYQIPGKPEIVDSASELTA 121
+L +G+L + A V D G + C A+N G E K N +V V + E V + S L
Sbjct: 1316 ILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLN 1375
Query: 122 GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 181
+ N C EG+ P+ + W+ D + + +V + T
Sbjct: 1376 QLTNLF--CEVEGT-PSPIIMWYKDNVQVTESSTIQTVNNGK----------ILKLFRAT 1422
Query: 182 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVE--PEGGAVAPGG 239
P G +SC +A+ A + + L ++ P +V
Sbjct: 1423 PEDAG----RYSC---------KAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNR 1469
Query: 240 TVTLTCEVPAQPSPQIHWMKDVSDLERG 267
V L C+V P P IHW KD L G
Sbjct: 1470 DVALECQVKGTPFPDIHWFKDGKPLFLG 1497
Score = 35.8 bits (81), Expect = 0.057
Identities = 39/147 (26%), Positives = 66/147 (44%), Gaps = 8/147 (5%)
Query: 3 AGTAVGAWVLVLSLWGAVVG-AQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSV 61
AGTA+G L + + + + + +P+ L C+ PP K G +S+
Sbjct: 4064 AGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESI 4123
Query: 62 A-RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELT 120
RVL +GSL + V D G + C A N G + S ++ V+ +P P I + T
Sbjct: 4124 RQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTST-KLTVH-VP--PRIRSTEGHYT 4179
Query: 121 AGVPNK-VGTCVSEGSYPAGTLSWHLD 146
++ + CV++G P ++W D
Sbjct: 4180 VNENSQAILPCVADG-IPTPAINWKKD 4205
Score = 35.0 bits (79), Expect = 0.097
Identities = 45/203 (22%), Positives = 71/203 (34%), Gaps = 30/203 (14%)
Query: 63 RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAG 122
R L N SL L +V D G + C + G S + Q P K ++ T G
Sbjct: 569 RTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVF--LTVQEPPKVTVMPKNQSFTGG 626
Query: 123 VPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTP 182
++V S YP ++W ++ +V + + R G +++ P
Sbjct: 627 --SEVSIMCSATGYPKPKIAWTVNDMFIVGSHR--------YRMTSDGTLFIKN---AAP 673
Query: 183 ARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVT 242
G + C S + T +E +L+V VA G
Sbjct: 674 KDAG----IYGCLASNSAGTDKQNSTLRY---------IEAPKLMVVQSELLVALGDITV 720
Query: 243 LTCEVPAQPSPQIHWMKDVSDLE 265
+ C+ P PQ+ W K DLE
Sbjct: 721 MECKTSGIPPPQVKWFK--GDLE 741
Score = 35.0 bits (79), Expect = 0.097
Identities = 53/243 (21%), Positives = 89/243 (36%), Gaps = 28/243 (11%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLGG---GPWDSVARVLPNGSLFLPAVGIQDEGI 82
I+ GE + L C+ PP + W P+ LP+GS+ + D G+
Sbjct: 1089 ISVLAGEEVTLPCE-VKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGM 1147
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLS 142
+ C A N G T++ ++ V+ +P P+I L V +V + P ++
Sbjct: 1148 YLCVATNIAGNVTQA-VKLNVH-VP--PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVIT 1203
Query: 143 WHLDGKP-LVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLP 201
W G LV E VS +P+ L Q+ TP+ G ++C +
Sbjct: 1204 WSKGGSTMLVDGEHHVS-------NPDGTLSIDQA----TPSDAG----IYTCVAT---- 1244
Query: 202 RHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDV 261
I V EP +E+++ + C P P I W+ +
Sbjct: 1245 NIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNG 1304
Query: 262 SDL 264
+L
Sbjct: 1305 REL 1307
Score = 33.1 bits (74), Expect = 0.37
Identities = 57/240 (23%), Positives = 87/240 (36%), Gaps = 37/240 (15%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGG----PWDSVARVLPNGSLFLPAVGIQDE 80
+++ GE L L CK A P +L W +DSV + L + V +D
Sbjct: 4268 DVSLNKGEQLRLSCK-ATGIPLPKLTWTFNNNIIPAHFDSVNG---HSELVIERVSKEDS 4323
Query: 81 GIFRCQAMNRNGKETKSNYRVRVYQIPG-KPEIVDSASELTAGVPNKVGTCVSEGSYPAG 139
G + C A N G + V V + P K + + E G N + C +G P
Sbjct: 4324 GTYVCTAENSVGFVKAIGF-VYVKEPPVFKGDYPSNWIEPLGG--NAILNCEVKGD-PTP 4379
Query: 140 TLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPG 199
T+ W N KGV + E + R + G +L V G ++C
Sbjct: 4380 TIQW---------NRKGVDI-EISHRIRQLGNGSLAIYGTVNEDAGD-----YTCV---- 4420
Query: 200 LPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMK 259
A A + R + +EP + GG + L C+ +P P I W +
Sbjct: 4421 -----ATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSR 4475
Score = 33.1 bits (74), Expect = 0.37
Identities = 20/64 (31%), Positives = 28/64 (43%), Gaps = 3/64 (4%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGP--WDSVARVLPNGSLFLPAVGIQDEGIFRCQAM 88
G ++L C+ A +P + W G WD VL N SL++ +D F C A
Sbjct: 4454 GGKIILNCQ-ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVAR 4512
Query: 89 NRNG 92
N G
Sbjct: 4513 NLMG 4516
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 56.2 bits (134), Expect = 4e-08
Identities = 69/261 (26%), Positives = 97/261 (37%), Gaps = 61/261 (23%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWD-------SVARVLPNGSLFLPAV-----GIQ 78
GEP L CK A +P +EW G + S +LP+GSLF +
Sbjct: 61 GEPTTLNCK-AEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKP 119
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 138
DEG + C A N G+ N + V + + + AG P + C +P
Sbjct: 120 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP-AILECQPPRGHPE 178
Query: 139 GTLSWHLDGKPLVPNEKGVSVKE-----QTRRHPETGLFTLQSELMVTPARGGDP----- 188
T+ W D + E+ +S++ R + G++T MV R DP
Sbjct: 179 PTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGE-RDSDPAELTV 237
Query: 189 --RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCE 246
RPTF LR PI Q+V+E E V C+
Sbjct: 238 FERPTF-------------LRR-PIN------------QVVLEEEA--------VEFRCQ 263
Query: 247 VPAQPSPQIHWMKDVSDLERG 267
V P P + W KD +DL RG
Sbjct: 264 VQGDPQPTVRWKKDDADLPRG 284
Score = 45.1 bits (105), Expect = 9e-05
Identities = 52/247 (21%), Positives = 85/247 (34%), Gaps = 44/247 (17%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR--VLPNGSLFLPAVGIQDEGI 82
++ GEP +L+C+ P + WK D + G L + D G+
Sbjct: 157 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 216
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIP-------GKPEIVDSASELTAGVPNKVGTCVSEGS 135
+ C N G+ + V++ P + + + A E C +G
Sbjct: 217 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEF---------RCQVQGD 267
Query: 136 YPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCS 195
P T+ W D L +K+ +TL+ + ++ G T+ C
Sbjct: 268 -PQPTVRWKKDDADLPRGR--YDIKDD---------YTLRIKKTMSTDEG-----TYMCI 310
Query: 196 FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 255
+ + A T ++ Q VV P VA G TVT CE P P +
Sbjct: 311 AENRVGKMEASATLTVR---------APPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAV 361
Query: 256 HWMKDVS 262
W K+ S
Sbjct: 362 FWQKEGS 368
Score = 32.7 bits (73), Expect = 0.48
Identities = 14/41 (34%), Positives = 21/41 (51%)
Query: 225 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLE 265
++V P V+ G TL C+ +P+P I W KD +E
Sbjct: 48 RIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVE 88
Score = 29.3 bits (64), Expect = 5.3
Identities = 60/253 (23%), Positives = 99/253 (39%), Gaps = 36/253 (14%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPW---DSVARVLPNGSLFLPAVGIQ 78
G N T + +LKCK A P + W G + D A + G+L + + I
Sbjct: 439 GPANQTLAVDGTALLKCK-ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRIS 497
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELT--AGVPNKVGTCVSEGSY 136
D G + C A + +G+ + S V + + +L+ G P+K V++ +
Sbjct: 498 DTGTYTCVATSSSGETSWS----AVLDVTESGATISKNYDLSDLPGPPSK--PQVTDVTK 551
Query: 137 PAGTLSWHLDGKPLVPN--------EKGVSVKEQT-RRHPETGLFTLQ----SELMVTPA 183
+ TLSW +P + VS QT H +T L+T++ + + +
Sbjct: 552 NSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMV 611
Query: 184 RGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQ-----LVVEPEGGAVAPG 238
R +P+ S P +RT I P + V +VQ ++V V
Sbjct: 612 RAINPQ-----GLSDPSPMSDPVRTQDISPPA-QGVDHRQVQKELGDVLVRLHNPVVLTP 665
Query: 239 GTVTLTCEVPAQP 251
TV +T V QP
Sbjct: 666 TTVQVTWTVDRQP 678
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 56.2 bits (134), Expect = 4e-08
Identities = 69/261 (26%), Positives = 97/261 (37%), Gaps = 61/261 (23%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWD-------SVARVLPNGSLFLPAV-----GIQ 78
GEP L CK A +P +EW G + S +LP+GSLF +
Sbjct: 45 GEPTTLNCK-AEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKP 103
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 138
DEG + C A N G+ N + V + + + AG P + C +P
Sbjct: 104 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP-AILECQPPRGHPE 162
Query: 139 GTLSWHLDGKPLVPNEKGVSVKE-----QTRRHPETGLFTLQSELMVTPARGGDP----- 188
T+ W D + E+ +S++ R + G++T MV R DP
Sbjct: 163 PTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGE-RDSDPAELTV 221
Query: 189 --RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCE 246
RPTF LR PI Q+V+E E V C+
Sbjct: 222 FERPTF-------------LRR-PIN------------QVVLEEEA--------VEFRCQ 247
Query: 247 VPAQPSPQIHWMKDVSDLERG 267
V P P + W KD +DL RG
Sbjct: 248 VQGDPQPTVRWKKDDADLPRG 268
Score = 45.1 bits (105), Expect = 9e-05
Identities = 52/247 (21%), Positives = 85/247 (34%), Gaps = 44/247 (17%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR--VLPNGSLFLPAVGIQDEGI 82
++ GEP +L+C+ P + WK D + G L + D G+
Sbjct: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 200
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIP-------GKPEIVDSASELTAGVPNKVGTCVSEGS 135
+ C N G+ + V++ P + + + A E C +G
Sbjct: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEF---------RCQVQGD 251
Query: 136 YPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCS 195
P T+ W D L +K+ +TL+ + ++ G T+ C
Sbjct: 252 -PQPTVRWKKDDADLPRGR--YDIKDD---------YTLRIKKTMSTDEG-----TYMCI 294
Query: 196 FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 255
+ + A T ++ Q VV P VA G TVT CE P P +
Sbjct: 295 AENRVGKMEASATLTVR---------APPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAV 345
Query: 256 HWMKDVS 262
W K+ S
Sbjct: 346 FWQKEGS 352
Score = 32.7 bits (73), Expect = 0.48
Identities = 14/41 (34%), Positives = 21/41 (51%)
Query: 225 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLE 265
++V P V+ G TL C+ +P+P I W KD +E
Sbjct: 32 RIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVE 72
Score = 29.3 bits (64), Expect = 5.3
Identities = 60/253 (23%), Positives = 99/253 (39%), Gaps = 36/253 (14%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPW---DSVARVLPNGSLFLPAVGIQ 78
G N T + +LKCK A P + W G + D A + G+L + + I
Sbjct: 423 GPANQTLAVDGTALLKCK-ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRIS 481
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELT--AGVPNKVGTCVSEGSY 136
D G + C A + +G+ + S V + + +L+ G P+K V++ +
Sbjct: 482 DTGTYTCVATSSSGETSWS----AVLDVTESGATISKNYDLSDLPGPPSK--PQVTDVTK 535
Query: 137 PAGTLSWHLDGKPLVPN--------EKGVSVKEQT-RRHPETGLFTLQ----SELMVTPA 183
+ TLSW +P + VS QT H +T L+T++ + + +
Sbjct: 536 NSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMV 595
Query: 184 RGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQ-----LVVEPEGGAVAPG 238
R +P+ S P +RT I P + V +VQ ++V V
Sbjct: 596 RAINPQ-----GLSDPSPMSDPVRTQDISPPA-QGVDHRQVQKELGDVLVRLHNPVVLTP 649
Query: 239 GTVTLTCEVPAQP 251
TV +T V QP
Sbjct: 650 TTVQVTWTVDRQP 662
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 54.3 bits (129), Expect = 2e-07
Identities = 62/248 (25%), Positives = 92/248 (37%), Gaps = 38/248 (15%)
Query: 20 VVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGG---PWDSVARVLPNGSLFLPAVG 76
V+ QN +GE + L+C A PP R+ W G P D + P+G L++ V
Sbjct: 345 VIQPQNTEVLVGESVTLECS-ATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVV 403
Query: 77 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSY 136
D G + C A N + + IV + + T ++V V EG
Sbjct: 404 QGDSGEYACSATNNIDSVHATAFI-----------IVQALPQFTVTPQDRV---VIEGQ- 448
Query: 137 PAGTLSWHLDGK----PLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTF 192
T+ + + K P++ KG S RRH TL+ + +G +
Sbjct: 449 ---TVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQG-----QY 500
Query: 193 SCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPS 252
C + + + +QPRV PV P V G V L C +P
Sbjct: 501 ECQAVNIIGSQKVVAHLTVQPRV-TPV------FASIPSDTTVEVGANVQLPCSSQGEPE 553
Query: 253 PQIHWMKD 260
P I W KD
Sbjct: 554 PAITWNKD 561
Score = 53.9 bits (128), Expect = 2e-07
Identities = 52/206 (25%), Positives = 80/206 (38%), Gaps = 23/206 (11%)
Query: 59 DSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE 118
DS +L +G+L + D+GI++C A N G+ +R + P +P V
Sbjct: 291 DSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQN 350
Query: 119 LTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSEL 178
V V S +P +SW + +P + V++ P GL+
Sbjct: 351 TEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNIT------PSGGLYIQN--- 401
Query: 179 MVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPG 238
V G+ ++CS + + A TA I + + +P Q V P+ V G
Sbjct: 402 -VVQGDSGE----YACSATNNIDSVHA--TAFI---IVQALP----QFTVTPQDRVVIEG 447
Query: 239 GTVTLTCEVPAQPSPQIHWMKDVSDL 264
TV CE P P I W K S L
Sbjct: 448 QTVDFQCEAKGNPPPVIAWTKGGSQL 473
Score = 45.4 bits (106), Expect = 7e-05
Identities = 38/154 (24%), Positives = 69/154 (44%), Gaps = 15/154 (9%)
Query: 9 AWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR--VLP 66
A+++V +L V Q+ G+ + +C+ A PP + W GG R VL
Sbjct: 425 AFIIVQALPQFTVTPQDRVVIEGQTVDFQCE-AKGNPPPVIAWTKGGSQLSVDRRHLVLS 483
Query: 67 NGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNK 126
+G+L + V + D+G + CQA+N G + V + +P + + + + +
Sbjct: 484 SGTLRISGVALHDQGQYECQAVNIIGSQKV------VAHLTVQPRVTPVFASIPSDTTVE 537
Query: 127 VGT-----CVSEGSYPAGTLSWHLDGKPLVPNEK 155
VG C S+G P ++W+ DG + + K
Sbjct: 538 VGANVQLPCSSQGE-PEPAITWNKDGVQVTESGK 570
Score = 40.0 bits (92), Expect = 0.003
Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 176 SELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 235
++L+ T A G+ + C + R + A I P E + E ++ EP+ V
Sbjct: 204 ADLLKTYAESGNAQAAAICEYPR---RIQGRSVATITP---EELNCERPRITSEPQDADV 257
Query: 236 APGGTVTLTCEVPAQPSPQIHWMKDVSDL 264
G TV TC P P+I W+++ ++L
Sbjct: 258 TSGNTVYFTCRAEGNPKPEIIWLRNNNEL 286
Score = 28.5 bits (62), Expect = 9.1
Identities = 31/133 (23%), Positives = 48/133 (36%), Gaps = 16/133 (12%)
Query: 27 TARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR--VLPNGSLFLPAVGIQDEGIFR 84
T +G + L C + +P + W G + + P G L + VG D G +
Sbjct: 535 TVEVGANVQLPCS-SQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYE 593
Query: 85 CQAMNRNGKETKS---NYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTL 141
C A N G + S + V G P + S E A V + + T
Sbjct: 594 CVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINS----------TR 643
Query: 142 SWHLDGKPLVPNE 154
+ D +P PN+
Sbjct: 644 THLFDSRPRSPND 656
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 53.9 bits (128), Expect = 2e-07
Identities = 62/264 (23%), Positives = 105/264 (39%), Gaps = 37/264 (14%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRC 85
+ +GE VL C+ A PP R+ W GG +G L +PA +D G + C
Sbjct: 590 VLVAVGEEAVLVCE-ASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTC 648
Query: 86 QAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHL 145
+A+N G + + ++ V P ++ + ++T + P T++W
Sbjct: 649 RAVNELG-DASAEIQLAVGHAP---QLTELPRDVTVELGRSALLACRATGRPPPTVTWRR 704
Query: 146 -DGKPLVPNEKGVSV---KEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCS----FS 197
DG+PL G+ + + R P++G+ +S V P + + + C F
Sbjct: 705 GDGQPL-----GLRLGAGRGSRSRQPDSGVLFFES---VAP----EDQAPYVCEARNVFG 752
Query: 198 PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPA-QPSPQIH 256
R + T P++ P V G V+L C V A +P P+ H
Sbjct: 753 KVQAEARLIVTGHAPPQIASSAPTVRV-----------LEGQPVSLPCIVLAGRPLPERH 801
Query: 257 WMKDVSDLERGAGRTRRGGANCRL 280
W+KD L G+ + R + L
Sbjct: 802 WLKDGRPLPPGSRHSIRADGSLHL 825
Score = 48.9 bits (115), Expect = 7e-06
Identities = 64/244 (26%), Positives = 103/244 (42%), Gaps = 34/244 (13%)
Query: 20 VVGAQNITARIGEPLVLKCK---GAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVG 76
+V A N+T GE VL C+ AP +W++ VA+ L + SL + +
Sbjct: 403 LVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQ-LADLSLEISGII 461
Query: 77 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSY 136
D G ++C A N NG T+++ + V + P + I S+ + GV KV +C + G Y
Sbjct: 462 PTDGGRYQCVASNANG-VTRASVWLLVREAP-QVSIHTSSQHFSQGVEVKV-SCSASG-Y 517
Query: 137 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPET-GLFTLQSELMVTPARGGDPRPTFSCS 195
P +SW + + L +E +R H + G +Q V P G+ +SC
Sbjct: 518 PTPHISWSRESQAL---------QEDSRIHVDAQGTLIIQG---VAPEDAGN----YSCQ 561
Query: 196 FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 255
+ + + T +P + V VV VA G L CE P P++
Sbjct: 562 ATNEVGTDQETVTL----YYTDPPSVSAVNAVV-----LVAVGEEAVLVCEASGVPPPRV 612
Query: 256 HWMK 259
W +
Sbjct: 613 IWYR 616
Score = 46.2 bits (108), Expect = 4e-05
Identities = 40/156 (25%), Positives = 63/156 (40%), Gaps = 32/156 (20%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVAR---VLPNGSLFLPAVGIQDEGI 82
+TA+ GE + L C+ A PP + W P + +LP+GSL L V + D G
Sbjct: 966 VTAKAGEEVTLDCE-AKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGH 1024
Query: 83 FRCQAMNRNGK---------ETKSNYRVRVYQIPGKPEIVDSAS---------------- 117
+ C A N G + +++++ + +P P + S
Sbjct: 1025 YECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLLQPTPRSVRLCHL 1084
Query: 118 ELTAGVPNKVGT---CVSEGSYPAGTLSWHLDGKPL 150
L A +P T C+S+ + TLS HL PL
Sbjct: 1085 SLRAPLPPPFATPTSCLSQACLSSSTLSLHLSPYPL 1120
Score = 45.4 bits (106), Expect = 7e-05
Identities = 59/252 (23%), Positives = 92/252 (36%), Gaps = 39/252 (15%)
Query: 24 QNITARIGEPLVLKCKGAPKKPP---------QRLEWKLGGGPWDSVARVLPNGSLFLPA 74
+++T +G +L C+ + PP Q L +LG G S +R +G LF +
Sbjct: 676 RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR-GSRSRQPDSGVLFFES 734
Query: 75 VGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSAS--ELTAGVPNKVGTCVS 132
V +D+ + C+A N GK + P P+I SA + G P + C+
Sbjct: 735 VAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP--PQIASSAPTVRVLEGQPVSL-PCIV 791
Query: 133 EGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTF 192
P W DG+PL P + S++ H + L + +
Sbjct: 792 LAGRPLPERHWLKDGRPLPPGSRH-SIRADGSLHLDRAL--------------QEHAGRY 836
Query: 193 SCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPS 252
SC A TA Q R E V ++ G +L C P+
Sbjct: 837 SCV---------ATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 887
Query: 253 PQIHWMKDVSDL 264
P I W K+ + L
Sbjct: 888 PTITWTKETNAL 899
Score = 35.8 bits (81), Expect = 0.057
Identities = 52/218 (23%), Positives = 76/218 (34%), Gaps = 33/218 (15%)
Query: 59 DSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE 118
DS V G+L + V +D G + CQA N G + ++ V +Y +A
Sbjct: 534 DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQET---VTLYYTDPPSVSAVNAVV 590
Query: 119 LTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSEL 178
L A V C + G P + W+ G ++ +G S S
Sbjct: 591 LVAVGEEAVLVCEASG-VPPPRVIWYRGGLEMILAPEGSS-----------------SGK 632
Query: 179 MVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPG 238
+ PA T++C L +A IQ V L E+ P V G
Sbjct: 633 LRIPAAQERDAGTYTCRAVNEL----GDASAEIQLAVGHAPQLTEL-----PRDVTVELG 683
Query: 239 GTVTLTCEVPAQPSPQIHWMKDVSD---LERGAGRTRR 273
+ L C +P P + W + L GAGR R
Sbjct: 684 RSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSR 721
Score = 28.9 bits (63), Expect = 7.0
Identities = 21/62 (33%), Positives = 28/62 (45%), Gaps = 5/62 (8%)
Query: 209 APIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERGA 268
A Q V +P P QLV P V+PG T L+C V + + W++D L
Sbjct: 390 AKAQIVVTDPPP----QLVPAPNV-TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST 444
Query: 269 GR 270
GR
Sbjct: 445 GR 446
Score = 28.9 bits (63), Expect = 7.0
Identities = 30/106 (28%), Positives = 48/106 (45%), Gaps = 18/106 (16%)
Query: 56 GPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDS 115
GP +V++ G+L + QD G + C A N G S+ +R+ + KP I +
Sbjct: 903 GPHYNVSK---EGTLLIAQPSAQDAGAYVCTATNTVG---FSSQEMRL-SVNTKPRIHMN 955
Query: 116 ASELTAGVPNKVGT---------CVSEGSYPAGTLSWHLDGKPLVP 152
S A VP +V C ++GS P ++W D +P+ P
Sbjct: 956 GSR-NANVPLQVTAKAGEEVTLDCEAKGS-PPPLVTWTKDSRPVPP 999
>gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]
Length = 1007
Score = 52.0 bits (123), Expect = 8e-07
Identities = 61/221 (27%), Positives = 90/221 (40%), Gaps = 47/221 (21%)
Query: 33 PLVLKCKGAPKKPPQRLEWKLGGGPWDSVA----RVLPNGSLFL---PAVG--------I 77
P + C+ A +PP + W L G P V +LP+G+L L PA G
Sbjct: 48 PARMSCQ-ASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALS 106
Query: 78 QDEGIFRCQAMNRNGKETKSNYRVRV------YQIPGKPEIVDSASELTAGVPNKVGTCV 131
D G++ C+A NR G R+ V +QI + + + T C
Sbjct: 107 TDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTL-------ECG 159
Query: 132 SEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPT 191
+P T+SW DGKPL Q RH +G L++ A D T
Sbjct: 160 PPWGHPEPTVSWWKDGKPLA---------LQPGRHTVSG-----GSLLMARAEKSD-EGT 204
Query: 192 FSC--SFSPGLPRHRALRTAPIQPRVW-EPVPLEEVQLVVE 229
+ C + S G RA R + +P+ + EPV L V++ +E
Sbjct: 205 YMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLE 245
Score = 30.0 bits (66), Expect = 3.1
Identities = 47/161 (29%), Positives = 63/161 (39%), Gaps = 34/161 (21%)
Query: 129 TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH--PETGLFTLQSELMVTPARG- 185
+C + G P T+ W L+G+PL S+ H P+ L LQ PARG
Sbjct: 52 SCQASGQ-PPPTIRWLLNGQPL-------SMVPPDPHHLLPDGTLLLLQP-----PARGH 98
Query: 186 ---GDPRPT----FSCSFSPGLPRHRALRTAPIQ-PRVWEPVPLEEVQLVVEPEGGAVAP 237
G T ++C S L TA + R+ V E+ Q ++P
Sbjct: 99 AHDGQALSTDLGVYTCEAS------NRLGTAVSRGARLSVAVLREDFQ--IQPRDMVAVV 150
Query: 238 GGTVTLTCEVP-AQPSPQIHWMKDVSDLERGAGR-TRRGGA 276
G TL C P P P + W KD L GR T GG+
Sbjct: 151 GEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGS 191
Score = 28.5 bits (62), Expect = 9.1
Identities = 10/34 (29%), Positives = 17/34 (50%)
Query: 225 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 258
Q++V P+ G ++C+ QP P I W+
Sbjct: 33 QILVHPQDQLFQGPGPARMSCQASGQPPPTIRWL 66
>gi|221316762 neurotrimin isoform 4 [Homo sapiens]
Length = 316
Score = 50.8 bits (120), Expect = 2e-06
Identities = 62/257 (24%), Positives = 100/257 (38%), Gaps = 49/257 (19%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWK-------LGGGPWDSVARVL------PNGSLF 71
N+T R GE L+C R+ W G W RV+ S+
Sbjct: 44 NVTVRQGESATLRC--TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIE 101
Query: 72 LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TC 130
+ V + DEG + C N +T + + + P+IV+ +S+++ N + TC
Sbjct: 102 IQNVDVYDEGPYTCSVQTDNHPKTSRVHLI----VQVSPKIVEISSDISINEGNNISLTC 157
Query: 131 VSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRP 190
++ G P T++W + + P G +++ +Q +T + GD
Sbjct: 158 IATGR-PEPTVTW----RHISPKAVGFVSEDE--------YLEIQG---ITREQSGD--- 198
Query: 191 TFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQ 250
+ CS S + AP+ RV V + + E +G V G TL CE A
Sbjct: 199 -YECSASNDV-------AAPVVRRV--KVTVNYPPYISEAKGTGVPVGQKGTLQCEASAV 248
Query: 251 PSPQIHWMKDVSDLERG 267
PS + W KD L G
Sbjct: 249 PSAEFQWYKDDKRLIEG 265
Score = 30.0 bits (66), Expect = 3.1
Identities = 34/142 (23%), Positives = 56/142 (39%), Gaps = 11/142 (7%)
Query: 23 AQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGI 82
+ +I+ G + L C A +P + W+ +V V + L + + + G
Sbjct: 142 SSDISINEGNNISLTCI-ATGRPEPTVTWRHISPK--AVGFVSEDEYLEIQGITREQSGD 198
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVP-NKVGTCVSEGS-YPAGT 140
+ C A N +V V P + A GVP + GT E S P+
Sbjct: 199 YECSASNDVAAPVVRRVKVTV----NYPPYISEAKG--TGVPVGQKGTLQCEASAVPSAE 252
Query: 141 LSWHLDGKPLVPNEKGVSVKEQ 162
W+ D K L+ +KGV V+ +
Sbjct: 253 FQWYKDDKRLIEGKKGVKVENR 274
>gi|221316757 neurotrimin isoform 3 [Homo sapiens]
Length = 355
Score = 50.8 bits (120), Expect = 2e-06
Identities = 62/257 (24%), Positives = 100/257 (38%), Gaps = 49/257 (19%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWK-------LGGGPWDSVARVL------PNGSLF 71
N+T R GE L+C R+ W G W RV+ S+
Sbjct: 44 NVTVRQGESATLRC--TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIE 101
Query: 72 LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TC 130
+ V + DEG + C N +T + + + P+IV+ +S+++ N + TC
Sbjct: 102 IQNVDVYDEGPYTCSVQTDNHPKTSRVHLI----VQVSPKIVEISSDISINEGNNISLTC 157
Query: 131 VSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRP 190
++ G P T++W + + P G +++ +Q +T + GD
Sbjct: 158 IATGR-PEPTVTW----RHISPKAVGFVSEDE--------YLEIQG---ITREQSGD--- 198
Query: 191 TFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQ 250
+ CS S + AP+ RV V + + E +G V G TL CE A
Sbjct: 199 -YECSASNDV-------AAPVVRRV--KVTVNYPPYISEAKGTGVPVGQKGTLQCEASAV 248
Query: 251 PSPQIHWMKDVSDLERG 267
PS + W KD L G
Sbjct: 249 PSAEFQWYKDDKRLIEG 265
Score = 30.0 bits (66), Expect = 3.1
Identities = 34/142 (23%), Positives = 56/142 (39%), Gaps = 11/142 (7%)
Query: 23 AQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGI 82
+ +I+ G + L C A +P + W+ +V V + L + + + G
Sbjct: 142 SSDISINEGNNISLTCI-ATGRPEPTVTWRHISPK--AVGFVSEDEYLEIQGITREQSGD 198
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVP-NKVGTCVSEGS-YPAGT 140
+ C A N +V V P + A GVP + GT E S P+
Sbjct: 199 YECSASNDVAAPVVRRVKVTV----NYPPYISEAKG--TGVPVGQKGTLQCEASAVPSAE 252
Query: 141 LSWHLDGKPLVPNEKGVSVKEQ 162
W+ D K L+ +KGV V+ +
Sbjct: 253 FQWYKDDKRLIEGKKGVKVENR 274
>gi|115298665 neurotrimin isoform 2 [Homo sapiens]
Length = 344
Score = 50.8 bits (120), Expect = 2e-06
Identities = 62/257 (24%), Positives = 100/257 (38%), Gaps = 49/257 (19%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWK-------LGGGPWDSVARVL------PNGSLF 71
N+T R GE L+C R+ W G W RV+ S+
Sbjct: 44 NVTVRQGESATLRC--TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIE 101
Query: 72 LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TC 130
+ V + DEG + C N +T + + + P+IV+ +S+++ N + TC
Sbjct: 102 IQNVDVYDEGPYTCSVQTDNHPKTSRVHLI----VQVSPKIVEISSDISINEGNNISLTC 157
Query: 131 VSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRP 190
++ G P T++W + + P G +++ +Q +T + GD
Sbjct: 158 IATGR-PEPTVTW----RHISPKAVGFVSEDE--------YLEIQG---ITREQSGD--- 198
Query: 191 TFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQ 250
+ CS S + AP+ RV V + + E +G V G TL CE A
Sbjct: 199 -YECSASNDV-------AAPVVRRV--KVTVNYPPYISEAKGTGVPVGQKGTLQCEASAV 248
Query: 251 PSPQIHWMKDVSDLERG 267
PS + W KD L G
Sbjct: 249 PSAEFQWYKDDKRLIEG 265
Score = 30.0 bits (66), Expect = 3.1
Identities = 34/142 (23%), Positives = 56/142 (39%), Gaps = 11/142 (7%)
Query: 23 AQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGI 82
+ +I+ G + L C A +P + W+ +V V + L + + + G
Sbjct: 142 SSDISINEGNNISLTCI-ATGRPEPTVTWRHISPK--AVGFVSEDEYLEIQGITREQSGD 198
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVP-NKVGTCVSEGS-YPAGT 140
+ C A N +V V P + A GVP + GT E S P+
Sbjct: 199 YECSASNDVAAPVVRRVKVTV----NYPPYISEAKG--TGVPVGQKGTLQCEASAVPSAE 252
Query: 141 LSWHLDGKPLVPNEKGVSVKEQ 162
W+ D K L+ +KGV V+ +
Sbjct: 253 FQWYKDDKRLIEGKKGVKVENR 274
>gi|7705413 neurotrimin isoform 1 [Homo sapiens]
Length = 344
Score = 50.8 bits (120), Expect = 2e-06
Identities = 62/257 (24%), Positives = 100/257 (38%), Gaps = 49/257 (19%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWK-------LGGGPWDSVARVL------PNGSLF 71
N+T R GE L+C R+ W G W RV+ S+
Sbjct: 44 NVTVRQGESATLRC--TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIE 101
Query: 72 LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TC 130
+ V + DEG + C N +T + + + P+IV+ +S+++ N + TC
Sbjct: 102 IQNVDVYDEGPYTCSVQTDNHPKTSRVHLI----VQVSPKIVEISSDISINEGNNISLTC 157
Query: 131 VSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRP 190
++ G P T++W + + P G +++ +Q +T + GD
Sbjct: 158 IATGR-PEPTVTW----RHISPKAVGFVSEDE--------YLEIQG---ITREQSGD--- 198
Query: 191 TFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQ 250
+ CS S + AP+ RV V + + E +G V G TL CE A
Sbjct: 199 -YECSASNDV-------AAPVVRRV--KVTVNYPPYISEAKGTGVPVGQKGTLQCEASAV 248
Query: 251 PSPQIHWMKDVSDLERG 267
PS + W KD L G
Sbjct: 249 PSAEFQWYKDDKRLIEG 265
Score = 30.0 bits (66), Expect = 3.1
Identities = 34/142 (23%), Positives = 56/142 (39%), Gaps = 11/142 (7%)
Query: 23 AQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGI 82
+ +I+ G + L C A +P + W+ +V V + L + + + G
Sbjct: 142 SSDISINEGNNISLTCI-ATGRPEPTVTWRHISPK--AVGFVSEDEYLEIQGITREQSGD 198
Query: 83 FRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVP-NKVGTCVSEGS-YPAGT 140
+ C A N +V V P + A GVP + GT E S P+
Sbjct: 199 YECSASNDVAAPVVRRVKVTV----NYPPYISEAKG--TGVPVGQKGTLQCEASAVPSAE 252
Query: 141 LSWHLDGKPLVPNEKGVSVKEQ 162
W+ D K L+ +KGV V+ +
Sbjct: 253 FQWYKDDKRLIEGKKGVKVENR 274
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 50.4 bits (119), Expect = 2e-06
Identities = 63/252 (25%), Positives = 96/252 (38%), Gaps = 37/252 (14%)
Query: 21 VGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPN--GSLFLPAVGIQ 78
V + G + L C+ A P + W+ GG AR +L +PA+
Sbjct: 1960 VSPERTQVHAGRTVRLYCRAAGV-PSATITWRKEGGSLPPQARSERTDIATLLIPAITTA 2018
Query: 79 DEGIFRCQAMNRNGKETKSNYRVRVYQI------PGKPEIVDSASELTAGVPNKVGTCVS 132
D G + C A + G + R++V + P +I S+ +T G + CV
Sbjct: 2019 DAGFYLCVATSPAGT---AQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLN-CVV 2074
Query: 133 EGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTF 192
GS A ++W+ G L P+ + V R P+ V+PA G+ +
Sbjct: 2075 AGSAHA-QVTWYRRGGSLPPHTQ---VHGSRLRLPQ-----------VSPADSGE----Y 2115
Query: 193 SCSFSPGLPRHRALRTAPIQPRV-----WEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 247
C G A T + + PVP + +EP VA G T+ L C V
Sbjct: 2116 VCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVV 2175
Query: 248 PAQPSPQIHWMK 259
P Q Q+ W K
Sbjct: 2176 PGQAHAQVTWHK 2187
Score = 47.4 bits (111), Expect = 2e-05
Identities = 62/244 (25%), Positives = 87/244 (35%), Gaps = 39/244 (15%)
Query: 27 TARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQ--DEGIFR 84
T + G+ KC P LEWK + + PNGS+ + VG + + G +R
Sbjct: 3032 TVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSI-ITIVGTRPSNHGTYR 3090
Query: 85 CQAMNRNG-KETKSNYRVR----VYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAG 139
C A N G ++ N V V +P P V +T CVS G P
Sbjct: 3091 CVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTL-------ECVSAGE-PRS 3142
Query: 140 TLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPG 199
+ W K + R + GL + L ++ A+ D T+ C
Sbjct: 3143 SARW--------TRISSTPAKLEQRTY---GLMDSHAVLQISSAKPSDAG-TYVCLAQNA 3190
Query: 200 LPRHRALRTAPIQPRVWEP----VPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 255
L + + P V EE +L VE G T TL C P+P I
Sbjct: 3191 LGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEA-------GHTATLRCSATGSPAPTI 3243
Query: 256 HWMK 259
HW K
Sbjct: 3244 HWSK 3247
Score = 42.7 bits (99), Expect = 5e-04
Identities = 51/235 (21%), Positives = 81/235 (34%), Gaps = 24/235 (10%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRC 85
+T + G+ +C A P LEW G G + G L LPAV D+ + C
Sbjct: 1875 LTVQPGQLAEFRCS-ATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLC 1933
Query: 86 QAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHL 145
+A + G++ V G P + S V P+ T++W
Sbjct: 1934 RAHSSAGQQVAR--AVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRK 1991
Query: 146 DGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSC-SFSPGLPRHR 204
+G L P R T + TL + T G + C + SP
Sbjct: 1992 EGGSLPPQ----------ARSERTDIATLLIPAITTADAG-----FYLCVATSPAGTAQA 2036
Query: 205 ALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMK 259
++ + P P++ +E +V G T+ L C V Q+ W +
Sbjct: 2037 RIQVVVLSASDASPPPVK-----IESSSPSVTEGQTLDLNCVVAGSAHAQVTWYR 2086
Score = 41.6 bits (96), Expect = 0.001
Identities = 60/241 (24%), Positives = 86/241 (35%), Gaps = 33/241 (13%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNR 90
GE L L C P + ++ W GG S + L L V D G + C+ M
Sbjct: 2741 GETLDLNCV-VPGQAHAQVTWHKRGGSLPSHHQTR-GSRLRLHHVSPADSGEYVCRVMGS 2798
Query: 91 NGK---------ETKSNYRVRVYQIPGKPEI-VDSASELTAGVPNKVGTCVSEGSYPAGT 140
+G E + V V G P I ++ +S A CV G A
Sbjct: 2799 SGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHA-Q 2857
Query: 141 LSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGL 200
++WH G L RH G ++ V+PA G+ +SC +
Sbjct: 2858 VTWHKRGGNL------------PARHQVHGPLLRLNQ--VSPADSGE----YSCQVTGSS 2899
Query: 201 PRHRALRTAPIQPRVWEPVPLEEVQ--LVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 258
A I+P P+P + + +E V G T+ L C VP Q Q+ W
Sbjct: 2900 GTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWY 2959
Query: 259 K 259
K
Sbjct: 2960 K 2960
Score = 41.2 bits (95), Expect = 0.001
Identities = 75/303 (24%), Positives = 105/303 (34%), Gaps = 54/303 (17%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGS-LFLPAVGIQDEGIFRCQAMN 89
G+ L L C A + Q + W GG AR +GS L L V D G + C+ +
Sbjct: 2451 GQTLDLNCLVAGQAHAQ-VTWHKRGGSLP--ARHQVHGSRLRLLQVTPADSGEYVCRVVG 2507
Query: 90 RNGKETKSNYRVRVYQIPGK-------PEIVDSASELTAGVPNKVGTCVSEGSYPAGTLS 142
+G + S ++ G P ++S+S A C+ P T++
Sbjct: 2508 SSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPH-TIT 2566
Query: 143 WHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPR 202
W+ G L + V + R P+ VTPA G+ + C S G
Sbjct: 2567 WYKRGGSLPSRHQIVGSR---LRIPQ-----------VTPADSGE----YVCHVSNGAGS 2608
Query: 203 HRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVS 262
IQ VP + +E V G T+ L C V QP I W K
Sbjct: 2609 RETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGG 2668
Query: 263 DLERGAGRTRRGGANCRLCGR---------IRAGNS------------SPGPGDPGRPGD 301
L R + G++ RL RA N+ SP G P PG
Sbjct: 2669 SL---PSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGS 2725
Query: 302 SRP 304
S P
Sbjct: 2726 SMP 2728
Score = 40.8 bits (94), Expect = 0.002
Identities = 61/238 (25%), Positives = 89/238 (37%), Gaps = 28/238 (11%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGS-LFLPAVGIQDEGIFRCQAMN 89
G+ L L C A ++P + W GG S R +GS L L + + D G + C+A N
Sbjct: 2644 GQTLDLNCVVA-RQPQAIITWYKRGGSLPS--RHQTHGSHLRLHQMSVADSGEYVCRA-N 2699
Query: 90 RNGKETKSNYRVRVYQIPGKPEI--------VDSASELTAGVPNKVGTCVSEGSYPAGTL 141
N +++ + V G P ++S+S A CV G A +
Sbjct: 2700 NNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHA-QV 2758
Query: 142 SWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLP 201
+WH G L + + + + R H V+PA G+ S P
Sbjct: 2759 TWHKRGGSLPSHHQ--TRGSRLRLHH------------VSPADSGEYVCRVMGSSGPLEA 2804
Query: 202 RHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMK 259
A V P P + +EP VA G T+ L C VP Q Q+ W K
Sbjct: 2805 SVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHK 2862
Score = 40.0 bits (92), Expect = 0.003
Identities = 60/235 (25%), Positives = 86/235 (36%), Gaps = 30/235 (12%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLF-LPAVGIQDEGIFRCQAMN 89
G+ L L C P + ++ W GG AR +GSL L V D G + C +
Sbjct: 2166 GQTLDLNCV-VPGQAHAQVTWHKRGGSLP--ARHQTHGSLLRLHQVTPADSGEYVCHVVG 2222
Query: 90 RNGK-ETKSNYRVRVYQIPGK--PEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLD 146
+G E + IPG P ++S+S A +CV G A ++W+
Sbjct: 2223 TSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHA-QVTWYKR 2281
Query: 147 GKPLVPNEKGVSVKEQTRRHPETG--LFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHR 204
G L RH G L+ Q+ +PA G + C S G+
Sbjct: 2282 GGSL------------PARHQVRGSRLYIFQA----SPADAGQ----YVCRASNGMEASI 2321
Query: 205 ALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMK 259
+ Q + +EP VA G T+ L C VP Q Q+ W K
Sbjct: 2322 TVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHK 2376
Score = 39.7 bits (91), Expect = 0.004
Identities = 50/227 (22%), Positives = 80/227 (35%), Gaps = 28/227 (12%)
Query: 36 LKCKGAPKKPPQRLEW-KLGGGPWDSVARVLPNGS-LFLPAVGIQDEGIFRCQAMNRNGK 93
L+C+ PP W + G P S + GS L P+V D G++ C N +
Sbjct: 1696 LRCQ-VSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQS 1754
Query: 94 ETKSNYRVRVYQIPGKPEIVDSASELTAGV---PNKVGTCVSEGSYPAGTLSWHLDGKPL 150
T S + V + P KP V + + V + C ++ PA TL W
Sbjct: 1755 NT-SRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGK 1813
Query: 151 VPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAP 210
+P TR G+ T+++ + T+ C+ S + T
Sbjct: 1814 LP----------TRAMDFNGILTIRNVQLSDAG-------TYVCTGSNMFAMDQGTATLH 1856
Query: 211 IQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHW 257
+Q P+ + + P V PG C P+P + W
Sbjct: 1857 VQASGTLSAPV----VSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW 1899
Score = 38.1 bits (87), Expect = 0.011
Identities = 31/93 (33%), Positives = 39/93 (41%), Gaps = 4/93 (4%)
Query: 2 AAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGG-PWDS 60
AAGT +L++ + Q + G V C + P KL G P DS
Sbjct: 3560 AAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDS 3619
Query: 61 VARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGK 93
L N L LP+V QD G + C A NR GK
Sbjct: 3620 R---LENNMLMLPSVRPQDAGTYVCTATNRQGK 3649
Score = 34.7 bits (78), Expect = 0.13
Identities = 55/247 (22%), Positives = 88/247 (35%), Gaps = 29/247 (11%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRC 85
+T G L+C A P + W P R L +L +P V QD G + C
Sbjct: 3221 LTVEAGHTATLRCS-ATGSPAPTIHWSKLRSPLPWQHR-LEGDTLIIPRVAQQDSGQYIC 3278
Query: 86 QAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHL 145
A + G ++ + V P + + AS + AG ++ C++ G+ P T W
Sbjct: 3279 NATSPAG-HAEATIILHVESPPYATTVPEHAS-VQAGETVQL-QCLAHGTPPL-TFQWSR 3334
Query: 146 DGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRA 205
G L G T ++EL+ + + C + + A
Sbjct: 3335 VGSSL------------------PGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEA 3376
Query: 206 LRTAPIQ-PRVWEP---VPLEEVQLV-VEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
+Q P P +P V V P+ + G +V C VP+ Q+ W K+
Sbjct: 3377 FAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKE 3436
Query: 261 VSDLERG 267
L G
Sbjct: 3437 GGQLPPG 3443
Score = 30.8 bits (68), Expect = 1.8
Identities = 22/74 (29%), Positives = 33/74 (44%), Gaps = 6/74 (8%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPN-----GSLFLPAVGIQ 78
++I A G+ + C A P + W+L G S RV G+L + V
Sbjct: 414 ESIQASRGQTVTFTCV-AIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKES 472
Query: 79 DEGIFRCQAMNRNG 92
D+G + C+AMN G
Sbjct: 473 DQGAYTCEAMNARG 486
>gi|61742797 basal cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 588
Score = 50.1 bits (118), Expect = 3e-06
Identities = 50/196 (25%), Positives = 75/196 (38%), Gaps = 12/196 (6%)
Query: 68 GSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTA--GVPN 125
G L L + DE + C ++ R+ V+ P E+ + L+
Sbjct: 108 GRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQ 167
Query: 126 KVGTCVSEGSYPAGTLSWHLDGK----PLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 181
++ TC S PA ++W+ +G+ P+ N +G R +GL +L S L +
Sbjct: 168 EIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVRE--ASGLLSLTSTLYLR 225
Query: 182 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVV---EPEGGAVAPG 238
R D +F C+ LP R R + P E VQ V G V G
Sbjct: 226 -LRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREG 284
Query: 239 GTVTLTCEVPAQPSPQ 254
TV L C PSP+
Sbjct: 285 DTVQLLCRGDGSPSPE 300
Score = 34.3 bits (77), Expect = 0.17
Identities = 47/232 (20%), Positives = 77/232 (33%), Gaps = 31/232 (13%)
Query: 29 RIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAM 88
R G+ + L C+G P+ ++L + V V G+L L V G + C+
Sbjct: 282 REGDTVQLLCRGDGSPSPEYTLFRLQDEQ-EEVLNVNLEGNLTLEGVTRGQSGTYGCRVE 340
Query: 89 NRNGKET---KSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHL 145
+ + + +RV + P + L+ + + S P L W
Sbjct: 341 DYDAADDVQLSKTLELRVAYLD--PLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK 398
Query: 146 DGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRA 205
D PL G + + G + ++ L P T SP
Sbjct: 399 DSTPL---GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSP------E 449
Query: 206 LRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHW 257
L+TA I+P+ G+ G VTL C P P++ W
Sbjct: 450 LKTAEIEPKA----------------DGSWREGDEVTLICSARGHPDPKLSW 485
>gi|31543106 basal cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 628
Score = 50.1 bits (118), Expect = 3e-06
Identities = 50/196 (25%), Positives = 75/196 (38%), Gaps = 12/196 (6%)
Query: 68 GSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTA--GVPN 125
G L L + DE + C ++ R+ V+ P E+ + L+
Sbjct: 108 GRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQ 167
Query: 126 KVGTCVSEGSYPAGTLSWHLDGK----PLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 181
++ TC S PA ++W+ +G+ P+ N +G R +GL +L S L +
Sbjct: 168 EIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVRE--ASGLLSLTSTLYLR 225
Query: 182 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVV---EPEGGAVAPG 238
R D +F C+ LP R R + P E VQ V G V G
Sbjct: 226 -LRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREG 284
Query: 239 GTVTLTCEVPAQPSPQ 254
TV L C PSP+
Sbjct: 285 DTVQLLCRGDGSPSPE 300
Score = 34.3 bits (77), Expect = 0.17
Identities = 47/232 (20%), Positives = 77/232 (33%), Gaps = 31/232 (13%)
Query: 29 RIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAM 88
R G+ + L C+G P+ ++L + V V G+L L V G + C+
Sbjct: 282 REGDTVQLLCRGDGSPSPEYTLFRLQDEQ-EEVLNVNLEGNLTLEGVTRGQSGTYGCRVE 340
Query: 89 NRNGKET---KSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHL 145
+ + + +RV + P + L+ + + S P L W
Sbjct: 341 DYDAADDVQLSKTLELRVAYLD--PLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK 398
Query: 146 DGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRA 205
D PL G + + G + ++ L P T SP
Sbjct: 399 DSTPL---GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSP------E 449
Query: 206 LRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHW 257
L+TA I+P+ G+ G VTL C P P++ W
Sbjct: 450 LKTAEIEPKA----------------DGSWREGDEVTLICSARGHPDPKLSW 485
Score = 30.0 bits (66), Expect = 3.1
Identities = 19/54 (35%), Positives = 25/54 (46%), Gaps = 6/54 (11%)
Query: 272 RRGGANCRLCGRIRAGNSSPGPGDPG--RPGDSRPAHWGHLVAKAATPRRGEEG 323
R+GG CR R +P PG+PG G +P G L+ A+ RG G
Sbjct: 573 RKGGPCCRQ----RREKGAPPPGEPGLSHSGSEQPEQTGLLMGGASGGARGGSG 622
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 50.1 bits (118), Expect = 3e-06
Identities = 62/251 (24%), Positives = 98/251 (39%), Gaps = 41/251 (16%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLGG----------GPWDSVARVLPNGSLFLPAVGIQDE 80
G+ L+L C + PQ + W+L G W V PNGSLF+ +V +D
Sbjct: 1956 GDKLLLNCSATGEPKPQ-IMWRLPSKAVVDQQHRVGSW---IHVYPNGSLFIGSVTEKDS 2011
Query: 81 GIFRCQAMNRNGKE---TKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYP 137
G++ C A N+ G + + R++ +I K ++ G +V C + GS P
Sbjct: 2012 GVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF---RKQVLHGKDFQV-DCKASGS-P 2066
Query: 138 AGTLSWHLDGKPLVPNE-KGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 196
+SW L ++ N + +TRR+ TL V A GD ++C
Sbjct: 2067 VPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFN-KVGVAEEGD----YTCYA 2121
Query: 197 SPGLPRHRA---LRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSP 253
L + L PR+ + + G T L CEV P P
Sbjct: 2122 QNTLGKDEMKVHLTVITAAPRIRQS----------NKTNKRIKAGDTAVLDCEVTGDPKP 2171
Query: 254 QIHWMKDVSDL 264
+I W+ +D+
Sbjct: 2172 KIFWLLPSNDM 2182
Score = 47.4 bits (111), Expect = 2e-05
Identities = 55/244 (22%), Positives = 92/244 (37%), Gaps = 31/244 (12%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLGG-------GPWDSVARVLPNGSLFLPAVG 76
+ IT G + LKC+ A +P + W L A V +G+L L +
Sbjct: 1753 KEITVHSGSTVELKCR-AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLS 1811
Query: 77 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGV--PNKVGTCVSEG 134
I D G ++C A N G+++ V++ I P I++ ++ G + C ++G
Sbjct: 1812 IYDRGFYKCVASNPGGQDS---LLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKG 1868
Query: 135 SYPAGTLSWHL-DGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFS 193
+ P ++ W L DG + P + + LF + + R T+
Sbjct: 1869 T-PQPSVYWVLSDGTEVKPLQ-----------FTNSKLFLFSNGTLYIRNLASSDRGTYE 1916
Query: 194 CSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSP 253
C + R + ++ RV P Q E V G + L C +P P
Sbjct: 1917 CIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTE-----VNFGDKLLLNCSATGEPKP 1971
Query: 254 QIHW 257
QI W
Sbjct: 1972 QIMW 1975
Score = 44.3 bits (103), Expect = 2e-04
Identities = 65/285 (22%), Positives = 97/285 (34%), Gaps = 39/285 (13%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEW------KLGGGPWDSVARVLPNGSLFLPAVGI 77
+ I A++G+ L C PP + W + GP + NGS +
Sbjct: 2345 EKIVAQLGKSTALNCS-VDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTR 2403
Query: 78 QDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT--CVSEGS 135
+D G +RC A N+ G K + + +I KP I+ A G+ + + CVS+G
Sbjct: 2404 EDAGKYRCAARNKVGYIEK----LVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDG- 2458
Query: 136 YPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSE--LMVTPARGGDPRPTFS 193
P + W + +V R G + L L++ A D R +
Sbjct: 2459 IPKPNIKWTMPSGYVVD------------RPQINGKYILHDNGTLVIKEATAYD-RGNYI 2505
Query: 194 CSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSP 253
C + L T P+ + P P G L C P P
Sbjct: 2506 CKAQNSV--GHTLITVPVMIVAYPPRITNR-----PPRSIVTRTGAAFQLHCVALGVPKP 2558
Query: 254 QIHW-MKDVSDLERGAGRTRRGGANCRLCGRIRAGNSSPGPGDPG 297
+I W M D S L + G L G + N P D G
Sbjct: 2559 EITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQN--PQTSDSG 2601
Score = 43.9 bits (102), Expect = 2e-04
Identities = 53/202 (26%), Positives = 87/202 (43%), Gaps = 23/202 (11%)
Query: 59 DSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVD-SAS 117
+S +VLPNG+L + V IQD G + C A N G + + V + + P I++
Sbjct: 1697 NSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTD---HLHVTLSVVSYPPRILERRTK 1753
Query: 118 ELTAGVPNKVG-TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQS 176
E+T + V C +EG P+ T++W ++ N+ VS Q R + T+
Sbjct: 1754 EITVHSGSTVELKCRAEGR-PSPTVTW------ILANQTVVSESSQGSRQ---AVVTVDG 1803
Query: 177 ELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVA 236
L++ D R + C S P + IQ PV LE+ + V+ G
Sbjct: 1804 TLVLHNLSIYD-RGFYKCVASN--PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGE-- 1858
Query: 237 PGGTVTLTCEVPAQPSPQIHWM 258
++ L C P P ++W+
Sbjct: 1859 ---SLKLPCTAKGTPQPSVYWV 1877
Score = 31.6 bits (70), Expect = 1.1
Identities = 23/70 (32%), Positives = 32/70 (45%), Gaps = 5/70 (7%)
Query: 27 TARIGEPLVLKCKGAPKKPPQRLEWKLGGG----PWDSVARVLPNGSLFLPAVGIQDEGI 82
T IGE L L C P + W + G +VL NG+L + V +D+G
Sbjct: 584 TVFIGETLDLPCHSTGI-PDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGY 642
Query: 83 FRCQAMNRNG 92
+RC A N +G
Sbjct: 643 YRCVAANPSG 652
Score = 30.4 bits (67), Expect = 2.4
Identities = 31/141 (21%), Positives = 48/141 (34%), Gaps = 8/141 (5%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGP-------WDSVARVLPNGSLFLPAVG 76
Q I GE L L C A P + W L G +S + NG+L++ +
Sbjct: 1850 QVIVGTWGESLKLPCT-AKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLA 1908
Query: 77 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSY 136
D G + C A + G E + ++ S +K+ S
Sbjct: 1909 SSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGE 1968
Query: 137 PAGTLSWHLDGKPLVPNEKGV 157
P + W L K +V + V
Sbjct: 1969 PKPQIMWRLPSKAVVDQQHRV 1989
Score = 30.0 bits (66), Expect = 3.1
Identities = 25/87 (28%), Positives = 38/87 (43%), Gaps = 6/87 (6%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVA----RVLPNGSLFLPAVGIQDE 80
N + G+ VL C+ P ++ W L S + NGSL + V + D
Sbjct: 2150 NKRIKAGDTAVLDCE-VTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDS 2208
Query: 81 GIFRCQAMNRNGKETKSNYRVRVYQIP 107
G + C A N +G +TK Y++ V P
Sbjct: 2209 GEYVCVARNPSGDDTKM-YKLDVVSKP 2234
>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
Length = 790
Score = 48.9 bits (115), Expect = 7e-06
Identities = 64/244 (26%), Positives = 103/244 (42%), Gaps = 34/244 (13%)
Query: 20 VVGAQNITARIGEPLVLKCK---GAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVG 76
+V A N+T GE VL C+ AP +W++ VA+ L + SL + +
Sbjct: 519 LVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQ-LADLSLEISGII 577
Query: 77 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSY 136
D G ++C A N NG T+++ + V + P + I S+ + GV KV +C + G Y
Sbjct: 578 PTDGGRYQCVASNANGV-TRASVWLLVREAP-QVSIHTSSQHFSQGVEVKV-SCSASG-Y 633
Query: 137 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPET-GLFTLQSELMVTPARGGDPRPTFSCS 195
P +SW + + L +E +R H + G +Q V P G+ +SC
Sbjct: 634 PTPHISWSRESQAL---------QEDSRIHVDAQGTLIIQG---VAPEDAGN----YSCQ 677
Query: 196 FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 255
+ + + T +P + V VV VA G L CE P P++
Sbjct: 678 ATNEVGTDQETVTLYYT----DPPSVSAVNAVV-----LVAVGEEAVLVCEASGVPPPRV 728
Query: 256 HWMK 259
W +
Sbjct: 729 IWYR 732
Score = 37.7 bits (86), Expect = 0.015
Identities = 22/67 (32%), Positives = 32/67 (47%), Gaps = 1/67 (1%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRC 85
+ +GE VL C+ A PP R+ W GG +G L +PA +D G + C
Sbjct: 706 VLVAVGEEAVLVCE-ASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTC 764
Query: 86 QAMNRNG 92
+A+N G
Sbjct: 765 RAVNELG 771
Score = 30.8 bits (68), Expect = 1.8
Identities = 32/140 (22%), Positives = 56/140 (40%), Gaps = 16/140 (11%)
Query: 59 DSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE 118
DS V G+L + V +D G + CQA N G + ++ V +Y +A
Sbjct: 650 DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQET---VTLYYTDPPSVSAVNAVV 706
Query: 119 LTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVS---VKEQTRRHPETGLFTLQ 175
L A V C + G P + W+ G ++ +G S ++ + + G +T +
Sbjct: 707 LVAVGEEAVLVCEASG-VPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCR 765
Query: 176 ---------SELMVTPARGG 186
+E+ + RGG
Sbjct: 766 AVNELGDASAEIQLAVGRGG 785
Score = 28.9 bits (63), Expect = 7.0
Identities = 21/62 (33%), Positives = 28/62 (45%), Gaps = 5/62 (8%)
Query: 209 APIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERGA 268
A Q V +P P QLV P V+PG T L+C V + + W++D L
Sbjct: 506 AKAQIVVTDPPP----QLVPAPNV-TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST 560
Query: 269 GR 270
GR
Sbjct: 561 GR 562
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.136 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,839,462
Number of Sequences: 37866
Number of extensions: 1116412
Number of successful extensions: 5259
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 182
Number of HSP's successfully gapped in prelim test: 306
Number of HSP's that attempted gapping in prelim test: 3363
Number of HSP's gapped (non-prelim): 2071
length of query: 342
length of database: 18,247,518
effective HSP length: 103
effective length of query: 239
effective length of database: 14,347,320
effective search space: 3429009480
effective search space used: 3429009480
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.