Search of human proteins with 25777698

Search of human proteins with 25777698

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|25777698 tripartite motif-containing 39 isoform 2 [Homo
sapiens]
         (488 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]   998   0.0  
gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]   982   0.0  
gi|22749269 ring finger protein 129 [Homo sapiens]                    392   e-109
gi|157743261 tripartite motif-containing 75 [Homo sapiens]            390   e-108
gi|21630277 tripartite motif-containing 11 [Homo sapiens]             374   e-103
gi|5730009 ret finger protein [Homo sapiens]                          362   e-100
gi|15208660 tripartite motif protein 21 [Homo sapiens]                357   2e-98
gi|112421127 tripartite motif-containing 58 [Homo sapiens]            337   1e-92
gi|5454014 tripartite motif-containing 38 [Homo sapiens]              327   2e-89
gi|37622899 ring finger protein 137 [Homo sapiens]                    326   3e-89
gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]    323   2e-88
gi|68160933 tripartite motif-containing 17 isoform 1 [Homo sapiens]   316   3e-86
gi|7705825 tripartite motif-containing 17 isoform 1 [Homo sapiens]    316   3e-86
gi|157426898 tripartite motif-containing 10 isoform 1 [Homo sapi...   315   6e-86
gi|31542779 tripartite motif family-like 1 [Homo sapiens]             295   8e-80
gi|68160935 tripartite motif-containing 17 isoform 2 [Homo sapiens]   291   1e-78
gi|42516572 tripartite motif-containing 41 isoform 1 [Homo sapiens]   290   3e-78
gi|51477692 tripartite motif-containing 6 isoform 1 [Homo sapiens]    272   6e-73
gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens]   271   1e-72
gi|18079262 tripartite motif-containing 6 isoform 2 [Homo sapiens]    270   2e-72
gi|15011941 tripartite motif protein TRIM4 isoform beta [Homo sa...   267   2e-71
gi|4557743 Mediterranean fever protein [Homo sapiens]                 257   1e-68
gi|14670266 tripartite motif protein TRIM4 isoform alpha [Homo s...   253   4e-67
gi|217035095 tripartite motif-containing 62 [Homo sapiens]            253   4e-67
gi|157426896 tripartite motif-containing 10 isoform 2 [Homo sapi...   250   2e-66
gi|149193331 tripartite motif protein 15 [Homo sapiens]               249   5e-66
gi|51477690 tripartite motif-containing 6 and tripartite motif-c...   239   5e-63
gi|4508005 tripartite motif-containing 26 [Homo sapiens]              238   7e-63
gi|14719418 tripartite motif protein TRIM5 isoform alpha [Homo s...   238   9e-63
gi|51477687 tripartite motif protein 34 isoform 1 [Homo sapiens]      236   3e-62

>gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]
          Length = 488

 Score =  998 bits (2579), Expect = 0.0
 Identities = 488/488 (100%), Positives = 488/488 (100%)

Query: 1   MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL 60
           MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL
Sbjct: 1   MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL 60

Query: 61  ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE 120
           ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE
Sbjct: 61  ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE 120

Query: 121 DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG 180
           DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG
Sbjct: 121 DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG 180

Query: 181 ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL 240
           ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL
Sbjct: 181 ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL 240

Query: 241 AHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRK 300
           AHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRK
Sbjct: 241 AHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRK 300

Query: 301 ILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTS 360
           ILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTS
Sbjct: 301 ILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTS 360

Query: 361 GRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLH 420
           GRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLH
Sbjct: 361 GRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLH 420

Query: 421 IKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLT 480
           IKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLT
Sbjct: 421 IKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLT 480

Query: 481 IRPPTDWE 488
           IRPPTDWE
Sbjct: 481 IRPPTDWE 488


>gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]
          Length = 518

 Score =  982 bits (2538), Expect = 0.0
 Identities = 488/518 (94%), Positives = 488/518 (94%), Gaps = 30/518 (5%)

Query: 1   MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL 60
           MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL
Sbjct: 1   MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL 60

Query: 61  ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE 120
           ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE
Sbjct: 61  ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE 120

Query: 121 DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG 180
           DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG
Sbjct: 121 DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG 180

Query: 181 ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL 240
           ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL
Sbjct: 181 ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL 240

Query: 241 AHLAAEVEGKCLQSGFEMLKDVKSTLEK------------------------------CE 270
           AHLAAEVEGKCLQSGFEMLKDVKSTLEK                              CE
Sbjct: 241 AHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCE 300

Query: 271 KVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVK 330
           KVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVK
Sbjct: 301 KVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVK 360

Query: 331 FVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGEL 390
           FVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGEL
Sbjct: 361 FVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGEL 420

Query: 391 TPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHI 450
           TPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHI
Sbjct: 421 TPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHI 480

Query: 451 YTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE 488
           YTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
Sbjct: 481 YTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE 518


>gi|22749269 ring finger protein 129 [Homo sapiens]
          Length = 471

 Score =  392 bits (1006), Expect = e-109
 Identities = 204/473 (43%), Positives = 293/473 (61%), Gaps = 11/473 (2%)

Query: 19  ALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSL 78
           AL NLQ E+SC +CLEYLK+PV I CGHNFC++C++  W+DL+  FPCPVCR    Y+S 
Sbjct: 6   ALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCFPYKSF 65

Query: 79  RPNRQLGSMVEIAKQLQ---AVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTH 135
           R N QL ++ EIAKQLQ   + +++ ++ ++C +H++ L+LFC +D E +C  C+ S  H
Sbjct: 66  RRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFSTKH 125

Query: 136 RAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILR 195
           + H + P+  A   ++E L+  LEPL   ++ + +    +  K  ELK+ VE +R++I  
Sbjct: 126 QKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREEINS 185

Query: 196 EFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSG 255
           EFE++   L  EQ+++L ++++EE +IL +L EN   L D    L HL  EVEGK +QS 
Sbjct: 186 EFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSVQSN 245

Query: 256 FEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPET 315
            E+L   KS   K + +K  E+   S  L K   + P QY  L +I+K    DV LD  T
Sbjct: 246 LELLTQAKSMHHKYQNLKCPEL--FSFRLTKYGFSLPPQYSGLDRIIKPFQVDVILDLNT 303

Query: 316 AHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHW 375
           AHP L++SEDRK+V++ E + R++   PRRF   P VL ++ F+SGRHYWEVEVG+K  W
Sbjct: 304 AHPQLLVSEDRKAVRY-ERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKPKW 362

Query: 376 AVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYE 435
            +GVC+D + R  +  P    G+W +  +    Y A+    T L   VKP ++GIFLDYE
Sbjct: 363 ILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLDYE 422

Query: 436 AGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE 488
            G LSFYN+ DRS +YTF D FTE +WP FY G      ++ PL I   +D E
Sbjct: 423 LGDLSFYNMNDRSILYTFNDCFTEAVWPYFYTG-----TDSEPLKICSVSDSE 470


>gi|157743261 tripartite motif-containing 75 [Homo sapiens]
          Length = 468

 Score =  390 bits (1003), Expect = e-108
 Identities = 201/457 (43%), Positives = 291/457 (63%), Gaps = 8/457 (1%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSR 74
           + AAAL  LQ EA CS+CL+YL +PV IECGHNFC++CI + W DL+  FPCPVCR   +
Sbjct: 2   AVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQCQ 61

Query: 75  YRSLRPNRQLGSMVEIAKQLQAVK---RKIRDESLCPQHHEALSLFCYEDQEAVCLICAI 131
               R N QLG M+EIAK LQ+ K   RK  + +LC +H++ LS+FC ED   +C +C  
Sbjct: 62  EGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQ 121

Query: 132 SHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQ 191
              H+ H V P++ A   Y+++    ++PL+++L ++ +  S++ KKP EL+ +VE++RQ
Sbjct: 122 PPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQ 181

Query: 192 QILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKC 251
           ++  EFE L++ LD EQQ +LSRL EEE+D  Q+L  N     +    L    ++V    
Sbjct: 182 ELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELS 241

Query: 252 LQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTL 311
             S  E+L  +K   E  E   +  +   SI L+++  +FP QY AL++I+K+   ++ L
Sbjct: 242 ELSELELLSQIKIFYES-ENESSPSI--FSIHLKRDGCSFPPQYSALQRIIKKFKVEIIL 298

Query: 312 DPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGD 371
           DPETAHPNL++SED+K V+F + R + +P  P+RFT  P VL    F SGRH+WE+EVGD
Sbjct: 299 DPETAHPNLIVSEDKKRVRFTK-RKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGD 357

Query: 372 KTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIF 431
           K+ WA+G+C+DS+  K       +   WR+ L +   +A    P TPL ++VK + +GIF
Sbjct: 358 KSEWAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFP-TPLLLEVKARAIGIF 416

Query: 432 LDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPG 468
           LDYE G +SFYN+ ++SHI TFTDTFT  L P FY G
Sbjct: 417 LDYEMGEISFYNMAEKSHICTFTDTFTGPLRPYFYVG 453


>gi|21630277 tripartite motif-containing 11 [Homo sapiens]
          Length = 468

 Score =  374 bits (959), Expect = e-103
 Identities = 205/449 (45%), Positives = 284/449 (63%), Gaps = 16/449 (3%)

Query: 22  NLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPN 81
           NLQ EA+C++CL+Y  +PV+ +CGHNFC+ CI R W   E  + CP CR+ S  R+LRPN
Sbjct: 9   NLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELSPQRNLRPN 68

Query: 82  RQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVV 141
           R L  M E+A++L         + +CP H E L+ FC ++   +C  C  S  H AH V 
Sbjct: 69  RPLAKMAEMARRLHPPSPV--PQGVCPAHREPLAAFCGDELRLLCAACERSGEHWAHRVR 126

Query: 142 PLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELH 201
           PL DA ++ K KL+K LE L +++Q+    ++  ++     +++VES+RQ +L EFE L 
Sbjct: 127 PLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLGEFERLR 186

Query: 202 RRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKD 261
           R L EE+Q LL RLEEEE ++L RLRE AAHLG +   LA L AE+EG+C      +L+D
Sbjct: 187 RLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPALGLLQD 246

Query: 262 VKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLV 321
           +K  L + + VK      V +EL +     P     L + L++   DVTLDP+TA+P L+
Sbjct: 247 IKDALRRVQDVKLQPPEVVPMEL-RTVCRVP----GLVETLRRFRGDVTLDPDTANPELI 301

Query: 322 LSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCR 381
           LSEDR+SV+  + R + LPD+P RF   PCVL  E FTSGRHYWEVEVGD+T WA+GVCR
Sbjct: 302 LSEDRRSVQRGDLR-QALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR 360

Query: 382 DSVSR--KGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTL 439
           ++V+R  KGEL+     G+W + ++ G  Y ++     PL  +  P+RVGIFLDYEAG L
Sbjct: 361 ENVNRKEKGELS--AGNGFW-ILVFLGSYYNSSERALAPL--RDPPRRVGIFLDYEAGHL 415

Query: 440 SFYNVTDRSHIYTFTD-TFTEKLWPLFYP 467
           SFY+ TD S ++ F +  F+  L PLF P
Sbjct: 416 SFYSATDGSLLFIFPEIPFSGTLRPLFSP 444


>gi|5730009 ret finger protein [Homo sapiens]
          Length = 513

 Score =  362 bits (929), Expect = e-100
 Identities = 191/492 (38%), Positives = 288/492 (58%), Gaps = 25/492 (5%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSR 74
           ++ +  E LQ E +C VCL+Y  EP++++CGHN C AC+ R W   E +  CP CR+T  
Sbjct: 2   ASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETFP 61

Query: 75  YRSLRPNRQLGSMVEIAKQLQAVKRKIR--DESLCPQHHEALSLFCYEDQEAVCLICAIS 132
            R +RPNR L ++ ++ KQL+  +      +  +C +H E L L+C EDQ  +C++C  S
Sbjct: 62  QRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRS 121

Query: 133 HTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQ 192
             HR H+V+PL++A + +KE++Q  L+ L++      R ++  E+   EL  L +  R++
Sbjct: 122 REHRGHSVLPLEEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREK 181

Query: 193 ILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCL 252
           I+ EFE+L+  L E +  LL+RLEE +  I   +             L+ L A++E K  
Sbjct: 182 IVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQ 241

Query: 253 QSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLI------ 306
           Q   E+L+D+  TL + E+++  E      +L++    F ++   L + LKQ        
Sbjct: 242 QPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSD 301

Query: 307 --------------ADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCV 352
                          DVTLDP+TA+P+L+LS++ + V++   + +DLPD P RF  +PCV
Sbjct: 302 MEKIQELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQ-QDLPDNPERFNLFPCV 360

Query: 353 LATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAAT 412
           L +  F +GRHYWEVEVGDK  W +GVC DSV RKG +T  P+ G+W V LW G +Y A 
Sbjct: 361 LGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWAL 420

Query: 413 TTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTD-TFTEKLWPLFYPGIRA 471
           T+P T L ++   +RVGIFLDY+AG +SFYNVT+R H +TF+  TF   + P F     +
Sbjct: 421 TSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSY-S 479

Query: 472 GRKNAAPLTIRP 483
           G K+AAPL I P
Sbjct: 480 GGKSAAPLIICP 491


>gi|15208660 tripartite motif protein 21 [Homo sapiens]
          Length = 475

 Score =  357 bits (915), Expect = 2e-98
 Identities = 197/473 (41%), Positives = 288/473 (60%), Gaps = 14/473 (2%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSR 74
           ++AA L  +  E +C +CL+   EPV IECGH+FC+ CI++  +       CPVCR+   
Sbjct: 2   ASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKG--GGSVCPVCRQRFL 59

Query: 75  YRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHT 134
            ++LRPNRQL +MV   K++    R+      C  H E L LFC +D +A+C +CA S  
Sbjct: 60  LKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRK 119

Query: 135 HRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQIL 194
           HR H +VPL++A QEY+EKLQ  L  L +K +   + +     K  + K+ VE+++ +I 
Sbjct: 120 HRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIH 179

Query: 195 REFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQS 254
            EF +    L EE+Q  L  LE++E++ L+ L E  A L  + + L  L +E++ +C  S
Sbjct: 180 AEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSS 239

Query: 255 GFEMLKDVKSTLEKCE--KVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLD 312
             E+L++V   LE+ E   +K +++TS  +   ++  + P     L+K+L+     +TLD
Sbjct: 240 ALELLQEVIIVLERSESWNLKDLDITSPEL---RSVCHVP----GLKKMLRTCAVHITLD 292

Query: 313 PETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDK 372
           P+TA+P L+LSEDR+ V+  +T+ + +P    RF  YP VL  + F SG+HYWEV+V  K
Sbjct: 293 PDTANPWLILSEDRRQVRLGDTQ-QSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGK 351

Query: 373 THWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFL 432
             W +GVCRDSV RKG      ++G+W + LWN  KY A T P TPLH++V P +VGIFL
Sbjct: 352 EAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFL 411

Query: 433 DYEAGTLSFYNVTDR-SHIYTFTD-TFTEKLWPLFYPGIRAGRKNAAPLTIRP 483
           DYEAG +SFYN+TD  S IY+F++  FT  L P F PG   G KN APLT+ P
Sbjct: 412 DYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCP 464


>gi|112421127 tripartite motif-containing 58 [Homo sapiens]
          Length = 486

 Score =  337 bits (865), Expect = 1e-92
 Identities = 187/469 (39%), Positives = 272/469 (57%), Gaps = 18/469 (3%)

Query: 21  ENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERD----FPCPVCRKTSRYR 76
           E L+ +A C VCL++L+EPV ++CGH+FC  CI+ + E  +      + CP CR   R  
Sbjct: 8   ERLREDARCPVCLDFLQEPVSVDCGHSFCLRCISEFCEKSDGAQGGVYACPQCRGPFRPS 67

Query: 77  SLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHR 136
             RPNRQL  +VE  ++L            C +H E LS FC ED+ A+C +C     HR
Sbjct: 68  GFRPNRQLAGLVESVRRLGLGAGP--GARRCARHGEDLSRFCEEDEAALCWVCDAGPEHR 125

Query: 137 AHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILRE 196
            H   PL +A   Y+ KLQ  LE + ++L++    +++  KK    K  VE +RQ+   E
Sbjct: 126 THRTAPLQEAAGSYQVKLQMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQRFRLE 185

Query: 197 FEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGF 256
           FE+    L +E+Q  L RLE EE+  LQRLRE+ + L  + + L  LA E++ +C +   
Sbjct: 186 FEKHRGFLAQEEQRQLRRLEAEERATLQRLRESKSRLVQQSKALKELADELQERCQRPAL 245

Query: 257 EMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETA 316
            +L+ V+  L + + V  +E  ++ +EL K     P +    R++L++   DV LDP TA
Sbjct: 246 GLLEGVRGVLSRSKAVTRLEAENIPMEL-KTACCIPGR----RELLRKFQVDVKLDPATA 300

Query: 317 HPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWA 376
           HP+L+L+ D +SV+  E   RD+P+ P RF  +PC+L  + F+SGRHYWEV VG+   W 
Sbjct: 301 HPSLLLTADLRSVQDGEP-WRDVPNNPERFDTWPCILGLQSFSSGRHYWEVLVGEGAEWG 359

Query: 377 VGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEA 436
           +GVC+D++ RKGE TP PE G W + L  G++Y    +P  PL     P+ +GIFLDYEA
Sbjct: 360 LGVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLESPRCIGIFLDYEA 419

Query: 437 GTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPT 485
           G +SFYNVTD S+IYTF   F+  L P F+        +A PL + P T
Sbjct: 420 GEISFYNVTDGSYIYTFNQLFSGLLRPYFF------ICDATPLILPPTT 462


>gi|5454014 tripartite motif-containing 38 [Homo sapiens]
          Length = 465

 Score =  327 bits (838), Expect = 2e-89
 Identities = 192/483 (39%), Positives = 271/483 (56%), Gaps = 26/483 (5%)

Query: 11  ASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWED------LERDF 64
           AS  ST   +E    EA+CS+CL  +  PV I CGH++C  CIT ++++       +  F
Sbjct: 2   ASTTSTKKMME----EATCSICLSLMTNPVSINCGHSYCHLCITDFFKNPSQKQLRQETF 57

Query: 65  PCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEA 124
            CP CR      SLRPN+QLGS++E  K+          E  C +H E   LFC ++ + 
Sbjct: 58  CCPQCRAPFHMDSLRPNKQLGSLIEALKETD-------QEMSCEEHGEQFHLFCEDEGQL 110

Query: 125 VCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKR 184
           +C  C  +  H+ HT   ++D  Q YKEKLQK +  L+Q     T  K S   +  + K 
Sbjct: 111 ICWRCERAPQHKGHTTALVEDVCQGYKEKLQKAVTKLKQLEDRCTEQKLSTAMRITKWKE 170

Query: 185 LVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLA 244
            V+ +RQ+I  +F+ L   L EE++  L RLE+EEQ  L RLR+  A LG K  +L    
Sbjct: 171 KVQIQRQKIRSDFKNLQCFLHEEEKSYLWRLEKEEQQTLSRLRDYEAGLGLKSNELKSHI 230

Query: 245 AEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQ 304
            E+E KC  S  ++L++V  TL +   VK     +VS+EL     N  + YF ++K+L+ 
Sbjct: 231 LELEEKCQGSAQKLLQNVNDTLSRSWAVKLETSEAVSLELH-TMCNVSKLYFDVKKMLRS 289

Query: 305 LIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHY 364
               VTLDP+TAH  L+LSEDR+ V    T+  +   + RRFT +PCVL  EGFTSGR Y
Sbjct: 290 HQVSVTLDPDTAHHELILSEDRRQVTRGYTQ-ENQDTSSRRFTAFPCVLGCEGFTSGRRY 348

Query: 365 WEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVK 424
           +EV+VG+ T W +GVC ++V R   +   P++G+W +RL     Y A T+P T LH+  +
Sbjct: 349 FEVDVGEGTGWDLGVCMENVQRGTGMKQEPQSGFWTLRLCKKKGYVALTSPPTSLHLHEQ 408

Query: 425 PKRVGIFLDYEAGTLSFYNVTDRSHIYTFTD-TFTEKLWPLFYPGIRAGRKNAAPLTIRP 483
           P  VGIFLDYEAG +SFYN     HI+TF   +F++ L P F           +PL + P
Sbjct: 409 PLLVGIFLDYEAGVVSFYNGNTGCHIFTFPKASFSDTLRPYFQV------YQYSPLFLPP 462

Query: 484 PTD 486
           P D
Sbjct: 463 PGD 465


>gi|37622899 ring finger protein 137 [Homo sapiens]
          Length = 485

 Score =  326 bits (836), Expect = 3e-89
 Identities = 183/480 (38%), Positives = 277/480 (57%), Gaps = 22/480 (4%)

Query: 18  AALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWE----DLERDFPCPVCRKTS 73
           A +E +  E +C +C+ +L+EP+ I+CGH+FC +C++  WE         + CP+CR   
Sbjct: 5   ALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPV 64

Query: 74  RYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISH 133
           + R+LRPN QL ++VE  + L+          LC +H E L +FC ED   +C  C+ S 
Sbjct: 65  QPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSP 124

Query: 134 THRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQI 193
            H AH+VVP++D   EYK +L + LE L+++ +E  + +  E K+    K  VE+R+Q I
Sbjct: 125 EHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSI 184

Query: 194 LREFEEL----------HRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHL 243
           + EFE+           HR+L  E    L+ L+ E  + +Q+L  N + L  + + L  +
Sbjct: 185 VWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRM 244

Query: 244 AAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILK 303
            AE++ +  +    ML+D++  L + +     +   +S+EL+ +      +   LR+ILK
Sbjct: 245 IAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDC-----RVLGLREILK 299

Query: 304 QLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRH 363
              ADV LDP+TA+  L++SEDRK V + +T  + LPD P RF  Y  VL ++  +SGRH
Sbjct: 300 TYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQK-LPDNPERFYRYNIVLGSQCISSGRH 358

Query: 364 YWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKV 423
           YWEVEVGD++ W +GVC+ +V RK  +   P  G+W +RL  G++Y A T  +  L + V
Sbjct: 359 YWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPV 418

Query: 424 KPKRVGIFLDYEAGTLSFYNVTD-RSHIYTFTD-TFTEKLWPLFYPGIRAGRKNAAPLTI 481
            P+RVGIF+DYEA  +SFYNVTD  SHI+TF    F  +L P F P    G  N APL I
Sbjct: 419 PPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAI 478


>gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]
          Length = 511

 Score =  323 bits (828), Expect = 2e-88
 Identities = 192/496 (38%), Positives = 283/496 (57%), Gaps = 48/496 (9%)

Query: 10  GASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERD------ 63
           G  A + A A E LQ EA+CS+CLE  +EPV +ECGH+FC+ACI R WE           
Sbjct: 11  GTGAEALALAAE-LQGEATCSICLELFREPVSVECGHSFCRACIGRCWERPGAGSVGAAT 69

Query: 64  ------FPCPVCRKTSRYRSLRPNRQLGSMVEIAKQL------------QAVKRKIRDES 105
                  PCP CR+ +R   LRPNRQL ++  + ++             QA   +    +
Sbjct: 70  RAPPFPLPCPQCREPARPSQLRPNRQLAAVATLLRRFSLPAAAPGEHGSQAAAARAA-AA 128

Query: 106 LCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKL 165
            C QH E   L+C +D  A+C++C  +  HR H V+PLD+A QE KE L+  L  L+++L
Sbjct: 129 RCGQHGEPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESRLRVLKKEL 188

Query: 166 QEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQR 225
           ++    +S+E+K+  EL + + + ++++  EF+ L   L E++  LL RLEE  +++ Q+
Sbjct: 189 EDCEVFRSTEKKESKELLKQMAAEQEKVGAEFQALRAFLVEQEGRLLGRLEELSREVAQK 248

Query: 226 LRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELE 285
             EN A LG +   L+ L+++++    +   + L++ KSTL +C  V   + T+VS E++
Sbjct: 249 QNENLAQLGVEITQLSKLSSQIQETAQKPDLDFLQEFKSTLSRCSNVPGPKPTTVSSEMK 308

Query: 286 KNFSNFPRQYFALRKILKQLIAD------------VTLDPETAHPNLVLSEDRKSVKFVE 333
               N   + F L+ +LK+   D            +TLDP+TA+P L+LS D K V+  E
Sbjct: 309 NKVWNVSLKTFVLKGMLKKFKEDLRGELEKEEKVELTLDPDTANPRLILSLDLKGVRLGE 368

Query: 334 TRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPL 393
            R +DLP+ P RF     VLA+ GF+SGRH+WEVEVG K  WA GV R+SV RKG LTP 
Sbjct: 369 -RAQDLPNHPCRFDTNTRVLASCGFSSGRHHWEVEVGSKDGWAFGVARESVRRKG-LTPF 426

Query: 394 -PETGYWRVRLWNGDKYAATTTPFTPL---HIKVKPKRVGIFLDYEAGTLSFYNVTDRSH 449
            PE G W ++L  G  +A T+   +PL   H+     RV + LD E G +SFY V D  H
Sbjct: 427 TPEEGVWALQLNGGQYWAVTSPERSPLSCGHL----SRVRVALDLEVGAVSFYAVEDMRH 482

Query: 450 IYTFTDTFTEKLWPLF 465
           +YTF   F E+++PLF
Sbjct: 483 LYTFRVNFQERVFPLF 498


>gi|68160933 tripartite motif-containing 17 isoform 1 [Homo sapiens]
          Length = 477

 Score =  316 bits (810), Expect = 3e-86
 Identities = 177/466 (37%), Positives = 260/466 (55%), Gaps = 36/466 (7%)

Query: 23  LQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL---------ERDFPCPVCRKTS 73
           LQ EA+CS+CL+Y  +PV+  CGHNFC+ACI   WE           +  FPCP CR+ S
Sbjct: 10  LQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMS 69

Query: 74  RYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISH 133
             R+L PNR L  + E+A+Q   +++    + LC +HHE L LFC +DQ  +C++C  S 
Sbjct: 70  PQRNLLPNRLLTKVAEMAQQHPGLQK----QDLCQEHHEPLKLFCQKDQSPICVVCRESR 125

Query: 134 THRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQI 193
            HR H V+P ++A Q YK KL++ +E L +++      ++ EE+   E +  V+ RR++I
Sbjct: 126 EHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERI 185

Query: 194 LREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQ 253
           + EFE+++  L EE+Q LL  LE EE++   RLRE+ A L  +   L  L  ++E +  Q
Sbjct: 186 VLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQLEERSTQ 245

Query: 254 SGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDP 313
              +ML+D+K  L +   V             +     P Q   LR  L+ ++ D T   
Sbjct: 246 GPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVPDAT--- 302

Query: 314 ETAHPNLVLSEDRKSVKFVETRLRDLPDTPR--------RFTFYPCVLATEGFTSGRHYW 365
            +A+P L+L E R+         R L  +P         RF  YPC +    F+SGRHYW
Sbjct: 303 -SAYPYLLLYESRQR--------RYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYW 353

Query: 366 EV--EVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKV 423
           EV   +     WA+GVCRD+VSRK  +   PE G+W V+L  G KY +T +  TP+ +  
Sbjct: 354 EVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLME 413

Query: 424 KPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTD-TFTEKLWPLFYPG 468
            P  +GIFLD+EAG +SFY+V+D SH++T++  TF   L P F  G
Sbjct: 414 PPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLG 459


>gi|7705825 tripartite motif-containing 17 isoform 1 [Homo sapiens]
          Length = 477

 Score =  316 bits (810), Expect = 3e-86
 Identities = 177/466 (37%), Positives = 260/466 (55%), Gaps = 36/466 (7%)

Query: 23  LQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL---------ERDFPCPVCRKTS 73
           LQ EA+CS+CL+Y  +PV+  CGHNFC+ACI   WE           +  FPCP CR+ S
Sbjct: 10  LQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMS 69

Query: 74  RYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISH 133
             R+L PNR L  + E+A+Q   +++    + LC +HHE L LFC +DQ  +C++C  S 
Sbjct: 70  PQRNLLPNRLLTKVAEMAQQHPGLQK----QDLCQEHHEPLKLFCQKDQSPICVVCRESR 125

Query: 134 THRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQI 193
            HR H V+P ++A Q YK KL++ +E L +++      ++ EE+   E +  V+ RR++I
Sbjct: 126 EHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERI 185

Query: 194 LREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQ 253
           + EFE+++  L EE+Q LL  LE EE++   RLRE+ A L  +   L  L  ++E +  Q
Sbjct: 186 VLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQLEERSTQ 245

Query: 254 SGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDP 313
              +ML+D+K  L +   V             +     P Q   LR  L+ ++ D T   
Sbjct: 246 GPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVPDAT--- 302

Query: 314 ETAHPNLVLSEDRKSVKFVETRLRDLPDTPR--------RFTFYPCVLATEGFTSGRHYW 365
            +A+P L+L E R+         R L  +P         RF  YPC +    F+SGRHYW
Sbjct: 303 -SAYPYLLLYESRQR--------RYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYW 353

Query: 366 EV--EVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKV 423
           EV   +     WA+GVCRD+VSRK  +   PE G+W V+L  G KY +T +  TP+ +  
Sbjct: 354 EVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLME 413

Query: 424 KPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTD-TFTEKLWPLFYPG 468
            P  +GIFLD+EAG +SFY+V+D SH++T++  TF   L P F  G
Sbjct: 414 PPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLG 459


>gi|157426898 tripartite motif-containing 10 isoform 1 [Homo
           sapiens]
          Length = 481

 Score =  315 bits (807), Expect = 6e-86
 Identities = 180/470 (38%), Positives = 276/470 (58%), Gaps = 22/470 (4%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWE----DLERDFPCPVCR 70
           ++AA++ +L  E +C +C   L+EPV I+CGHNFC+AC+TR+ E    DLE    CP+C+
Sbjct: 2   ASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLCK 61

Query: 71  KTSRYRSLRPNRQLGSMVEIAKQLQAVKRK-IRDESLCPQHHEALSLFCYEDQEAVCLIC 129
           +  R  S RPN QL ++VE  ++LQ V    + +E +C +H E +  FC +D+  +C++C
Sbjct: 62  EPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCVVC 121

Query: 130 AISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESR 189
             +  H  HT+  L+DA   Y+E++ KCL+ L ++ +EI   +S E K+   L   V ++
Sbjct: 122 REAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVSTK 181

Query: 190 RQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEG 249
           RQQ++ EF  L + L+E+Q +LL++LE ++ DIL++  E    +  +    + L  E+E 
Sbjct: 182 RQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEELEE 241

Query: 250 KCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLI--- 306
           K  +   E+L D++STL +CE  K  +  +VS EL +   +FP+Q   L++ +K  +   
Sbjct: 242 KNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQALPLQREMKMFLEKL 301

Query: 307 --------ADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGF 358
                   A ++LDP+T+HP L+LSED +  +F   + ++ PD P+RF    CVLA  G 
Sbjct: 302 CFELDYEPAHISLDPQTSHPKLLLSEDHQRAQF-SYKWQNSPDNPQRFDRATCVLAHTGI 360

Query: 359 TSGRHYWEVEVGDKTH---WAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTP 415
           T GRH W V + D  H     VGV  + V RKGEL   PE G W VRL  G   A  + P
Sbjct: 361 TGGRHTWVVSI-DLAHGGSCTVGVVSEDVQRKGELRLRPEEGVWAVRLAWGFVSALGSFP 419

Query: 416 FTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLF 465
            T L +K +P++V + LDYE G ++F N   R  IYTFT +FT K+ P F
Sbjct: 420 -TRLTLKEQPRQVRVSLDYEVGWVTFTNAVTREPIYTFTASFTRKVIPFF 468


>gi|31542779 tripartite motif family-like 1 [Homo sapiens]
          Length = 468

 Score =  295 bits (754), Expect = 8e-80
 Identities = 173/475 (36%), Positives = 272/475 (57%), Gaps = 23/475 (4%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSR 74
           STA  +ENL+ E +C +CL+Y   PV  ECGH+FC  C+ R WE+      CP C +T  
Sbjct: 2   STADLMENLREELTCFICLDYFSSPVTTECGHSFCLVCLLRSWEEHNTPLSCPECWRTLE 61

Query: 75  YRSLRPNRQLGSMVEIAKQLQAVKRKIRDES----LCPQHHEALSLFCYEDQEAVCLICA 130
               + N +LG +  IA+QL++   +  DE       P   +ALS    +D++       
Sbjct: 62  GPHFQSNERLGRLASIARQLRSQVLQSEDEQGSYGRMPTTAKALS----DDEQGGSAF-- 115

Query: 131 ISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRR 190
           ++ +H A+ V    +A + ++EKLQ+ L  L  + +E     + E+++    +   ++ +
Sbjct: 116 VAQSHGANRVHLSSEAEEHHREKLQEILNLLRVRRKEAQAVLTHEKERVKLCQEETKTCK 175

Query: 191 QQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGK 250
           Q ++ E+ ++H+ L EE+Q+ L  LE+EE++ +++LR N   L  + R L+ + A++E  
Sbjct: 176 QVVVSEYMKMHQFLKEEEQLQLQLLEQEEKENMRKLRNNEIKLTQQIRSLSKMIAQIESS 235

Query: 251 CLQSGFEMLKDVKSTLEKCEKV--KTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIAD 308
              S FE L++V+  LE+ E +  +  E T+  + L +           ++++L++   +
Sbjct: 236 SQSSAFESLEEVRGALERSEPLLLQCPEATTTELSLCR--------ITGMKEMLRKFSTE 287

Query: 309 VTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVE 368
           +TLDP TA+  LVLSED KSVK+  +R + LPD P RF     VL T+ FTSGRHYWEVE
Sbjct: 288 ITLDPATANAYLVLSEDLKSVKYGGSR-QQLPDNPERFDQSATVLGTQIFTSGRHYWEVE 346

Query: 369 VGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAA-TTTPFTPLHIKVKPKR 427
           VG+KT W VG+C+DSVSRKG L   P   +  + L  GD Y+   ++P    H++    +
Sbjct: 347 VGNKTEWEVGICKDSVSRKGNLPKPPGDLFSLIGLKIGDDYSLWVSSPLKGQHVREPVCK 406

Query: 428 VGIFLDYEAGTLSFYNVTDRSHIYTFTD-TFTEKLWPLFYPGIRAGRKNAAPLTI 481
           VG+FLDYE+G ++FYN TD S IY+F   +F E L P+F P +     N  PLTI
Sbjct: 407 VGVFLDYESGHIAFYNGTDESLIYSFPQASFQEALRPIFSPCLPNEGTNTDPLTI 461


>gi|68160935 tripartite motif-containing 17 isoform 2 [Homo sapiens]
          Length = 450

 Score =  291 bits (744), Expect = 1e-78
 Identities = 166/445 (37%), Positives = 244/445 (54%), Gaps = 36/445 (8%)

Query: 44  CGHNFCKACITRWWEDL---------ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQL 94
           CGHNFC+ACI   WE           +  FPCP CR+ S  R+L PNR L  + E+A+Q 
Sbjct: 4   CGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMSPQRNLLPNRLLTKVAEMAQQH 63

Query: 95  QAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKL 154
             +++    + LC +HHE L LFC +DQ  +C++C  S  HR H V+P ++A Q YK KL
Sbjct: 64  PGLQK----QDLCQEHHEPLKLFCQKDQSPICVVCRESREHRLHRVLPAEEAVQGYKLKL 119

Query: 155 QKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSR 214
           ++ +E L +++      ++ EE+   E +  V+ RR++I+ EFE+++  L EE+Q LL  
Sbjct: 120 EEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERIVLEFEKMNLYLVEEEQRLLQA 179

Query: 215 LEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKT 274
           LE EE++   RLRE+ A L  +   L  L  ++E +  Q   +ML+D+K  L +   V  
Sbjct: 180 LETEEEETASRLRESVACLDRQGHSLELLLLQLEERSTQGPLQMLQDMKEPLSRKNNVSV 239

Query: 275 MEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVET 334
                      +     P Q   LR  L+ ++ D T    +A+P L+L E R+       
Sbjct: 240 QCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVPDAT----SAYPYLLLYESRQR------ 289

Query: 335 RLRDLPDTPR--------RFTFYPCVLATEGFTSGRHYWEV--EVGDKTHWAVGVCRDSV 384
             R L  +P         RF  YPC +    F+SGRHYWEV   +     WA+GVCRD+V
Sbjct: 290 --RYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMNITGDALWALGVCRDNV 347

Query: 385 SRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNV 444
           SRK  +   PE G+W V+L  G KY +T +  TP+ +   P  +GIFLD+EAG +SFY+V
Sbjct: 348 SRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSHMGIFLDFEAGEVSFYSV 407

Query: 445 TDRSHIYTFTD-TFTEKLWPLFYPG 468
           +D SH++T++  TF   L P F  G
Sbjct: 408 SDGSHLHTYSQATFPGPLQPFFCLG 432


>gi|42516572 tripartite motif-containing 41 isoform 1 [Homo sapiens]
          Length = 630

 Score =  290 bits (741), Expect = 3e-78
 Identities = 166/440 (37%), Positives = 247/440 (56%), Gaps = 37/440 (8%)

Query: 62  RDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVK---RKIRDESLCPQHHEALSLFC 118
           R F CP CRK+   RS RPN QL +MV++ +Q+        ++ D+ +CP+H EAL LFC
Sbjct: 179 RCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALKLFC 238

Query: 119 YEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKK 178
             D+EA+C++C  S +H+ H+VVPL++  QEYK KLQ  +EPL + L+ + + K+ EE++
Sbjct: 239 EVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERR 298

Query: 179 PGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRR 238
             ELK  ++S    +  EF  L R L EEQ  L  RL E  +  L R    A+ L ++  
Sbjct: 299 VTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAA 358

Query: 239 DLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFAL 298
            L+ L AE + +  Q G  +L+D+K T  +CE+V+       S +  +  S+       +
Sbjct: 359 QLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTDAIV 418

Query: 299 RKILKQLI----ADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLA 354
           RK+ +        D+TLDP+TAHP L+LS DR+ V+  E R +++ D P+RF+   CVL 
Sbjct: 419 RKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERR-QEVADHPKRFSADCCVLG 477

Query: 355 TEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTP---------------------- 392
            +GF SGRHYWEVEVG +  WAVG  R+S   K ++ P                      
Sbjct: 478 AQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRRRL 537

Query: 393 -LPETGYWRVRLW----NGDKY-AATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTD 446
            LP+    +  +W    NG +Y A ++T  T L    KP+R G++LDYEAG L FYN   
Sbjct: 538 HLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAET 597

Query: 447 RSHIYTFTDTFT-EKLWPLF 465
            +H++TF+  F  E+++P F
Sbjct: 598 LAHVHTFSAAFLGERVFPFF 617



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 23/47 (48%), Positives = 33/47 (70%)

Query: 11 ASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWW 57
          A+ A T   ++ LQ EA C++CL+Y  +PV I CGHNFC+ C+T+ W
Sbjct: 2  AAVAMTPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLW 48


>gi|51477692 tripartite motif-containing 6 isoform 1 [Homo sapiens]
          Length = 516

 Score =  272 bits (695), Expect = 6e-73
 Identities = 174/504 (34%), Positives = 271/504 (53%), Gaps = 34/504 (6%)

Query: 8   EAGAS--AASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL----E 61
           +AGA   A  T+  L +++ E +C +CLE L EP+ I+CGH+FC+ACIT    +     E
Sbjct: 20  QAGARRVATMTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQE 79

Query: 62  RDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYED 121
            +  CPVC+ + +  +LRPNR L ++V   +++     K     LC  H E L LFC ED
Sbjct: 80  GERSCPVCQTSYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQED 139

Query: 122 QEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGE 181
            + +C +C  S  HR H    +++  QEY+EK Q+ L+ L+ + QE  +  +   +K   
Sbjct: 140 GKVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTS 199

Query: 182 LKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLA 241
            K  +E  R +I  EF +L   LD  +Q  L +LE+EE+  L+ + E    L  + + L 
Sbjct: 200 WKNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLR 259

Query: 242 HLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNF--SNFPRQYFALR 299
            L +++E +C  S  E+L+DV    E+ E     +  ++  +L   F   +  R     R
Sbjct: 260 ELISDLERRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCR 319

Query: 300 KI--LKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPC-VLATE 356
           ++  ++    DVTL+P TA+ NLVL+++R+ V+FV  ++   P    +   Y C VL ++
Sbjct: 320 ELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSG-PSCLEK--HYDCSVLGSQ 376

Query: 357 GFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPL-----------PETGYWRVRLWN 405
            F+SG+HYWEV+V  KT W +GVC +S+                    P++GYW + L +
Sbjct: 377 HFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQH 436

Query: 406 GDKYAA--TTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSH-IYTFTD-TFTEKL 461
             +Y A   ++P   L + V P+RVG+FLDYEAGT+SFYNVT+    IYTF+   F   L
Sbjct: 437 NHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTL 496

Query: 462 WPLFYPGIRAGRKNAAPLTIRPPT 485
            P F P          P+T+R P+
Sbjct: 497 CPYFNP-----CNCVIPMTLRRPS 515


>gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens]
          Length = 500

 Score =  271 bits (693), Expect = 1e-72
 Identities = 159/473 (33%), Positives = 252/473 (53%), Gaps = 13/473 (2%)

Query: 20  LENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLR 79
           ++++ +E  C +C ++ ++P+++ CGHNFC+ACI  +W    ++  CP C+   +Y +  
Sbjct: 32  IQDITMELHCPLCNDWFRDPLMLSCGHNFCEACIQDFWRLQAKETFCPECKMLCQYNNCT 91

Query: 80  PNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLIC--AISHTHRA 137
            N  L  +VE  K+L  +K        CP+H E L LF   D + +C  C  A     ++
Sbjct: 92  FNPVLDKLVEKIKKLPLLK----GHPQCPEHGENLKLFSKPDGKLICFQCKDARLSVGQS 147

Query: 138 HTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREF 197
              + + DA   + E+L      LE  L+E+   ++ +++     K      +Q +  EF
Sbjct: 148 KEFLQISDAVHFFTEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQHVSMEF 207

Query: 198 EELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKC-LQSGF 256
            +LH+ L  +++ +L+ L EE + + + +  N + L ++      +   ++ K   Q+ F
Sbjct: 208 LKLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSF 267

Query: 257 EMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNF--PRQYFALRKILKQL---IADVTL 311
           + LKD+ + L   E+   +  T   I  + N   +  P QY   R++   L   ++ +TL
Sbjct: 268 DFLKDITTLLHSLEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTL 327

Query: 312 DPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGD 371
           DP+TAHPNLVLS+ + SV   + + + +PD P RF     VL + GFTSG+ YWEVEV  
Sbjct: 328 DPKTAHPNLVLSKSQTSVWHGDIK-KIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAK 386

Query: 372 KTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIF 431
           KT W VGV R+S+ RKG     PE G+W +RL N     A   P   L +     +VGI+
Sbjct: 387 KTKWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGIY 446

Query: 432 LDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPP 484
           LDYE G LSFYN    +HIYTF++TF EKL+P F P +  G +N  PL I  P
Sbjct: 447 LDYEGGQLSFYNAKTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHILHP 499


>gi|18079262 tripartite motif-containing 6 isoform 2 [Homo sapiens]
          Length = 488

 Score =  270 bits (690), Expect = 2e-72
 Identities = 170/494 (34%), Positives = 266/494 (53%), Gaps = 32/494 (6%)

Query: 16  TAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL----ERDFPCPVCRK 71
           T+  L +++ E +C +CLE L EP+ I+CGH+FC+ACIT    +     E +  CPVC+ 
Sbjct: 2   TSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQT 61

Query: 72  TSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAI 131
           + +  +LRPNR L ++V   +++     K     LC  H E L LFC ED + +C +C  
Sbjct: 62  SYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCER 121

Query: 132 SHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQ 191
           S  HR H    +++  QEY+EK Q+ L+ L+ + QE  +  +   +K    K  +E  R 
Sbjct: 122 SQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERC 181

Query: 192 QILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKC 251
           +I  EF +L   LD  +Q  L +LE+EE+  L+ + E    L  + + L  L +++E +C
Sbjct: 182 RIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRC 241

Query: 252 LQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNF--SNFPRQYFALRKI--LKQLIA 307
             S  E+L+DV    E+ E     +  ++  +L   F   +  R     R++  ++    
Sbjct: 242 QGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWV 301

Query: 308 DVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPC-VLATEGFTSGRHYWE 366
           DVTL+P TA+ NLVL+++R+ V+FV  ++   P    +   Y C VL ++ F+SG+HYWE
Sbjct: 302 DVTLNPHTANLNLVLAKNRRQVRFVGAKVSG-PSCLEK--HYDCSVLGSQHFSSGKHYWE 358

Query: 367 VEVGDKTHWAVGVCRDSVSRKGELTPL-----------PETGYWRVRLWNGDKYAA--TT 413
           V+V  KT W +GVC +S+                    P++GYW + L +  +Y A   +
Sbjct: 359 VDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDS 418

Query: 414 TPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSH-IYTFTD-TFTEKLWPLFYPGIRA 471
           +P   L + V P+RVG+FLDYEAGT+SFYNVT+    IYTF+   F   L P F P    
Sbjct: 419 SPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNP---- 474

Query: 472 GRKNAAPLTIRPPT 485
                 P+T+R P+
Sbjct: 475 -CNCVIPMTLRRPS 487


>gi|15011941 tripartite motif protein TRIM4 isoform beta [Homo
           sapiens]
          Length = 474

 Score =  267 bits (682), Expect = 2e-71
 Identities = 164/486 (33%), Positives = 240/486 (49%), Gaps = 37/486 (7%)

Query: 21  ENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRP 80
           E++Q E +C +CL+Y ++PV IECGHNFC+ C+ R W      FPCP CR  S   +LRP
Sbjct: 4   EDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPSAPAALRP 63

Query: 81  NRQLGSMVEIAKQLQAVKRKIRD--ESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAH 138
           N  L  + E     +  +R++      LC +H E L LFC +DQ  VCL+C  S  H+ H
Sbjct: 64  NWALARLTE-----KTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQTH 118

Query: 139 TVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFE 198
            + P+D+A + Y+EKL K    L  K++++   +  E K   + K  ++S+R +I  EF 
Sbjct: 119 AMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKSQRMRISTEFS 178

Query: 199 ELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEM 258
           +LH  L EE+ + L RL +EE++  ++L EN   L      L  L  EV  K      E+
Sbjct: 179 KLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEVGEKSQAPTLEL 238

Query: 259 LKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHP 318
           L++ K  L +       E+  V+  LE        Q   ++++LK+    V L  +TAHP
Sbjct: 239 LQNPKEVLTR------SEIQDVNYSLEAVKVKTVCQIPLMKEMLKRFQVAVNLAEDTAHP 292

Query: 319 NLVLSEDRKSVK-----------------FVETRLRDLPDTPRRFTFYPCVLATEGFTSG 361
            LV S++ + VK                 F   R         RF   PCVL    FTSG
Sbjct: 293 KLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCVLGKNVFTSG 352

Query: 362 RHYWEVEVGDKTHWAVGVCRDSVSRKGELTPL-PETGYWRVRLWNGDKYAATTTPFTPLH 420
           +HYWEVE  D    AVGVCR+ V    + + + P+ G W +       +     P TP  
Sbjct: 353 KHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTPTQ 412

Query: 421 IKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLT 480
            +    RVG++LD   G +SFY+  D  H++TF+ +   +L P F+          A L 
Sbjct: 413 QEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSVSRLRPFFW------LSPLASLV 466

Query: 481 IRPPTD 486
           I P TD
Sbjct: 467 IPPVTD 472


>gi|4557743 Mediterranean fever protein [Homo sapiens]
          Length = 781

 Score =  257 bits (657), Expect = 1e-68
 Identities = 151/401 (37%), Positives = 228/401 (56%), Gaps = 25/401 (6%)

Query: 107 CPQHHEALSL-FCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKL 165
           C +H + + L FC +  E +CLIC++S  H+ H V P+++   E+K+K+QK LE L++  
Sbjct: 375 CKRHLKQVQLLFCEDHDEPICLICSLSQEHQGHRVRPIEEVALEHKKKIQKQLEHLKKLR 434

Query: 166 QEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQR 225
           +     +S  E+K     +  E+ +Q++ R+ E+++  L++++   ++ LE+  Q + Q 
Sbjct: 435 KSGEEQRSYGEEKAVSFLKQTEALKQRVQRKLEQVYYFLEQQEHFFVASLEDVGQMVGQI 494

Query: 226 LRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELE 285
            +     +      L  L  E+E K  QS +E+L+D+   L + + V   E  +   E++
Sbjct: 495 RKAYDTRVSQDIALLDALIGELEAKECQSEWELLQDIGDILHRAKTVPVPEKWTTPQEIK 554

Query: 286 KN---------FSNFPRQYFA--LRKILKQL-----------IADVTLDPETAHPNLVLS 323
           +          F     +YF+  LR  ++               +V LD ETA+PNL+ S
Sbjct: 555 QKIQLLHQKSEFVEKSTKYFSETLRSEMEMFNVPELIGAQAHAVNVILDAETAYPNLIFS 614

Query: 324 EDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDS 383
           +D KSV+ +  +   LPD P+RF     VL +  F SGR YWEVEVGDKT W +G C+ S
Sbjct: 615 DDLKSVR-LGNKWERLPDGPQRFDSCIIVLGSPSFLSGRRYWEVEVGDKTAWILGACKTS 673

Query: 384 VSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYN 443
           +SRKG +T  PE GYW V +   ++Y A++ P T L IK  PKRVGIF+DY  G++SFYN
Sbjct: 674 ISRKGNMTLSPENGYWVVIMMKENEYQASSVPPTRLLIKEPPKRVGIFVDYRVGSISFYN 733

Query: 444 VTDRSHIYTFTD-TFTEKLWPLFYPGIRAGRKNAAPLTIRP 483
           VT RSHIYTF   +F+  L P+F PG R G KN APLTI P
Sbjct: 734 VTARSHIYTFASCSFSGPLQPIFSPGTRDGGKNTAPLTICP 774


>gi|14670266 tripartite motif protein TRIM4 isoform alpha [Homo
           sapiens]
          Length = 500

 Score =  253 bits (645), Expect = 4e-67
 Identities = 164/510 (32%), Positives = 238/510 (46%), Gaps = 59/510 (11%)

Query: 21  ENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRP 80
           E++Q E +C +CL+Y ++PV IECGHNFC+ C+ R W      FPCP CR  S   +LRP
Sbjct: 4   EDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPSAPAALRP 63

Query: 81  NRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTV 140
           N  L  + E   + Q  +       LC +H E L LFC +DQ  VCL+C  S  H+ H +
Sbjct: 64  NWALARLTE---KTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQTHAM 120

Query: 141 VPLDDATQEYK--------------------------EKLQKCLEPLEQKLQEITRCKSS 174
            P+D+A + Y+                          EKL K    L  K++++   +  
Sbjct: 121 APIDEAFESYRTGNFDIHVDEWKRRLIRLLLYHSKQEEKLLKSQRNLVAKMKKVMHLQDV 180

Query: 175 EEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLG 234
           E K   + K  ++S+R +I  EF +LH  L EE+ + L RL +EE++  ++L EN   L 
Sbjct: 181 EVKNATQWKDKIKSQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLN 240

Query: 235 DKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQ 294
                L  L  EV  K      E+L++ K  L +       E+  V+  LE        Q
Sbjct: 241 QTIASLKKLILEVGEKSQAPTLELLQNPKEVLTR------SEIQDVNYSLEAVKVKTVCQ 294

Query: 295 YFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVK-----------------FVETRLR 337
              ++++LK+    V L  +TAHP LV S++ + VK                 F   R  
Sbjct: 295 IPLMKEMLKRFQVAVNLAEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNP 354

Query: 338 DLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPL-PET 396
                  RF   PCVL    FTSG+HYWEVE  D    AVGVCR+ V    + + + P+ 
Sbjct: 355 QKTAFVERFQHLPCVLGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDV 414

Query: 397 GYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDT 456
           G W +       +     P TP   +    RVG++LD   G +SFY+  D  H++TF+ +
Sbjct: 415 GIWAIYWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCS 474

Query: 457 FTEKLWPLFYPGIRAGRKNAAPLTIRPPTD 486
              +L P F+          A L I P TD
Sbjct: 475 SVSRLRPFFW------LSPLASLVIPPVTD 498


>gi|217035095 tripartite motif-containing 62 [Homo sapiens]
          Length = 475

 Score =  253 bits (645), Expect = 4e-67
 Identities = 152/468 (32%), Positives = 237/468 (50%), Gaps = 9/468 (1%)

Query: 22  NLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWW--EDLERDFPCPVCRKTSRYRSLR 79
           +L+ E  CS+CL   ++PV + C H FC+ CIT  W  ++ +    CP CR+T    +L 
Sbjct: 4   SLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEPALA 63

Query: 80  PNRQLGSMVEIAKQ--LQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRA 137
           P+ +L ++VE      L A+    R    C Q H+ + LFC  D+  +C  C     H  
Sbjct: 64  PSLKLANIVERYSSFPLDAILNARRAARPC-QAHDKVKLFCLTDRALLCFFCDEPALHEQ 122

Query: 138 HTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREF 197
           H V  +DDA  E + +L+  L+ L+   +E T      +++  E K   +S R  I   F
Sbjct: 123 HQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAF 182

Query: 198 EELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFE 257
           E LHR L E Q+ +L  LE +    L  + +       + R +   A  ++ +  ++   
Sbjct: 183 ERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRH 242

Query: 258 MLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLI---ADVTLDPE 314
                 ++L +  K K  E      +   +    P QY   + + + +    A +TLDP 
Sbjct: 243 TFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPG 302

Query: 315 TAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTH 374
           TAH  L+LS+D   V +     + L D+P+RF     VL +E F+SG HYWEV V +KT 
Sbjct: 303 TAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQ 362

Query: 375 WAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDY 434
           W +G+  ++ SRKG +   P  G++ + + +G++Y+A T P+T L+++ K  +VG+FLDY
Sbjct: 363 WVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDY 422

Query: 435 EAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPG-IRAGRKNAAPLTI 481
           + G L FYN  D S +YTF + F  KL   F PG   A  KN  PL I
Sbjct: 423 DQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRI 470


>gi|157426896 tripartite motif-containing 10 isoform 2 [Homo
           sapiens]
          Length = 395

 Score =  250 bits (638), Expect = 2e-66
 Identities = 135/367 (36%), Positives = 219/367 (59%), Gaps = 17/367 (4%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWE----DLERDFPCPVCR 70
           ++AA++ +L  E +C +C   L+EPV I+CGHNFC+AC+TR+ E    DLE    CP+C+
Sbjct: 2   ASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLCK 61

Query: 71  KTSRYRSLRPNRQLGSMVEIAKQLQAVKRK-IRDESLCPQHHEALSLFCYEDQEAVCLIC 129
           +  R  S RPN QL ++VE  ++LQ V    + +E +C +H E +  FC +D+  +C++C
Sbjct: 62  EPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCVVC 121

Query: 130 AISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESR 189
             +  H  HT+  L+DA   Y+E++ KCL+ L ++ +EI   +S E K+   L   V ++
Sbjct: 122 REAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVSTK 181

Query: 190 RQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEG 249
           RQQ++ EF  L + L+E+Q +LL++LE ++ DIL++  E    +  +    + L  E+E 
Sbjct: 182 RQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEELEE 241

Query: 250 KCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLI--- 306
           K  +   E+L D++STL +CE  K  +  +VS EL +   +FP+Q   L++ +K  +   
Sbjct: 242 KNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQALPLQREMKMFLEKL 301

Query: 307 --------ADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGF 358
                   A ++LDP+T+HP L+LSED +  +F   + ++ PD P+RF    CVLA  G 
Sbjct: 302 CFELDYEPAHISLDPQTSHPKLLLSEDHQRAQF-SYKWQNSPDNPQRFDRATCVLAHTGI 360

Query: 359 TSGRHYW 365
           T GRH W
Sbjct: 361 TGGRHTW 367


>gi|149193331 tripartite motif protein 15 [Homo sapiens]
          Length = 465

 Score =  249 bits (635), Expect = 5e-66
 Identities = 150/455 (32%), Positives = 241/455 (52%), Gaps = 34/455 (7%)

Query: 28  SCSVCLEYLKEPVIIECGHNFCKACITRWWE----DLERDFPCPVCRKTSRYRSLRPNRQ 83
           +C++C   L++ V I CGH FC+ C+    +       +   CP+C++  +  +      
Sbjct: 15  ACTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLCQEEEQAETPMAPVP 74

Query: 84  LGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPL 143
           LG +                E+ C +H E +  FC  D E +C+ C    TH+AHTV  L
Sbjct: 75  LGPL---------------GETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFL 119

Query: 144 DDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRR 203
           D+A Q Y+++L+  LE L  +  EI   K  E++K   L   +ES++ Q+   FE L + 
Sbjct: 120 DEAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQE 179

Query: 204 LDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVK 263
           L++++ +LL+RL E EQ I +   E    + ++   L     E+E KC Q   E+L+DV+
Sbjct: 180 LEQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQPASELLQDVR 239

Query: 264 STLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIAD-----------VTLD 312
               +CE    +   ++S +L K   +F R+   L ++++    +           +TLD
Sbjct: 240 VNQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPEMMRMFSENLAHHLEIDSGVITLD 299

Query: 313 PETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEV--EVG 370
           P+TA  +LVLSEDRKSV++   + + LPD+P RF   P VL   GF+SGRH W+V  ++G
Sbjct: 300 PQTASRSLVLSEDRKSVRYTRQK-KSLPDSPLRFDGLPAVLGFPGFSSGRHRWQVDLQLG 358

Query: 371 DKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGI 430
           D     VGV  + V RKGE+    E G W V + +  +  A+T+P T L +   P+ V +
Sbjct: 359 DGGGCTVGVAGEGVRRKGEMGLSAEDGVWAV-IISHQQCWASTSPGTDLPLSEIPRGVRV 417

Query: 431 FLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLF 465
            LDYEAG ++ +N   +  I+TFT +F+ K++P F
Sbjct: 418 ALDYEAGQVTLHNAQTQEPIFTFTASFSGKVFPFF 452


>gi|51477690 tripartite motif-containing 6 and tripartite
           motif-containing 34 [Homo sapiens]
          Length = 842

 Score =  239 bits (609), Expect = 5e-63
 Identities = 163/503 (32%), Positives = 264/503 (52%), Gaps = 42/503 (8%)

Query: 12  SAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDF----PCP 67
           S+A  +  L N+Q E +C +CLE L EP+ ++CGH+ C+ACIT   ++          CP
Sbjct: 352 SSAMASKILLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCP 411

Query: 68  VCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCL 127
           VC  +  +  L+ N+ L ++VE  K+++      +   LC  H E L LFC ED++ +C 
Sbjct: 412 VCGISYSFEHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICW 471

Query: 128 ICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVE 187
           +C  S  HR H  V  ++  +E +EKLQ  L+ L+++ +E  + ++   ++    K  V+
Sbjct: 472 LCERSQEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQ 531

Query: 188 SRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEV 247
           + RQ+I  EF++L   L+ E+Q  L RLEEEE+  L +  E    L  +++ +  L ++V
Sbjct: 532 TERQRIQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDV 591

Query: 248 EGKCLQSGFEMLKDVKSTLEKCE--KVKTMEVTSVSIELEKNFSNFPRQYFALRKI--LK 303
           E +   S  E+L+D+   ++  E  ++K  ++ S  ++   +  +  R     R++  ++
Sbjct: 592 ECRSQWSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKTVFHAPDLSRMLQMFRELTAVR 651

Query: 304 QLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRH 363
               DVTL+    + NLVLSED++ V  V       P  P +   Y  VL ++ F+SG+H
Sbjct: 652 CYWVDVTLNSVNLNLNLVLSEDQRQVISV-------PIWPFQCYNYG-VLGSQYFSSGKH 703

Query: 364 YWEVEVGDKTHWAVG------------VCRDSVSRKGELTPL-PETGYWRVRLWNGDKYA 410
           YWEV+V  KT W +G            V R   +R+   T   P  GYW + L N  KY 
Sbjct: 704 YWEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYG 763

Query: 411 ------ATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDR-SHIYTFTD-TFTEKLW 462
                 ++      L + V P RVG+FLDYEAG +SF+NVT   S IY F+   F++ ++
Sbjct: 764 VFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVY 823

Query: 463 PLFYPGIRAGRKNAAPLTIRPPT 485
           P F P         AP+T+ PP+
Sbjct: 824 PYFNPW-----NCPAPMTLCPPS 841



 Score =  163 bits (413), Expect = 3e-40
 Identities = 93/269 (34%), Positives = 147/269 (54%), Gaps = 6/269 (2%)

Query: 8   EAGAS--AASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL----E 61
           +AGA   A  T+  L +++ E +C +CLE L EP+ I+CGH+FC+ACIT    +     E
Sbjct: 20  QAGARRVATMTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQE 79

Query: 62  RDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYED 121
            +  CPVC+ + +  +LRPNR L ++V   +++     K     LC  H E L LFC ED
Sbjct: 80  GERSCPVCQTSYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQED 139

Query: 122 QEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGE 181
            + +C +C  S  HR H    +++  QEY+EK Q+ L+ L+ + QE  +  +   +K   
Sbjct: 140 GKVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTS 199

Query: 182 LKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLA 241
            K  +E  R +I  EF +L   LD  +Q  L +LE+EE+  L+ + E    L  + + L 
Sbjct: 200 WKNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLR 259

Query: 242 HLAAEVEGKCLQSGFEMLKDVKSTLEKCE 270
            L +++E +C  S  E+L+DV    E+ E
Sbjct: 260 ELISDLERRCQGSTMELLQDVSDVTERSE 288


>gi|4508005 tripartite motif-containing 26 [Homo sapiens]
          Length = 539

 Score =  238 bits (608), Expect = 7e-63
 Identities = 168/536 (31%), Positives = 271/536 (50%), Gaps = 83/536 (15%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSR 74
           +T+A L +L+ E +CS+CL+YL++PV I+CGH FC++C T           CP+C+K  +
Sbjct: 2   ATSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTTDVRPISGSRPVCPLCKKPFK 61

Query: 75  YRSLRPNRQLGSMVEIAKQLQA--------VKRKIRDESLCPQHHEALSLFCYEDQEAVC 126
             ++RP  QL S+VE  ++L+         V R+ +D  LC +H E L  +C +D + +C
Sbjct: 62  KENIRPVWQLASLVENIERLKVDKGRQPGEVTREQQDAKLCERHREKLHYYCEDDGKLLC 121

Query: 127 LICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLV 186
           ++C  S  HR HT V ++ A Q ++EK+   L  L +   +I   ++  E       + +
Sbjct: 122 VMCRESREHRPHTAVLMEKAAQPHREKILNHLSTLRRDRDKIQGFQAKGEADILAALKKL 181

Query: 187 ESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQ-RLRENAAHLGDKRRDLAHLAA 245
           + +RQ I+ EFE+ H+ L E ++ LL +L + EQ++ + R +  +  +G+  R LA + +
Sbjct: 182 QDQRQYIVAEFEQGHQFLREREEHLLEQLAKLEQELTEGREKFKSRGVGELAR-LALVIS 240

Query: 246 EVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQ- 304
           E+EGK  Q   E+++D +  L +  + K      ++  ++K    F  +  +L++ L++ 
Sbjct: 241 ELEGKAQQPAAELMQDTRDFLNRYPRKKFWVGKPIARVVKKKTGEFSDKLLSLQRGLREF 300

Query: 305 ---LIAD-------VTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLA 354
              L+ D       VTLDP++A   L LSED K V +     +     P++F   P VL 
Sbjct: 301 QGKLLRDLEYKTVSVTLDPQSASGYLQLSEDWKCVTYTSL-YKSAYLHPQQFDCEPGVLG 359

Query: 355 TEGFTSGRHY----------------------------------------WEVE-----V 369
           ++GFT G+ Y                                        WE +     +
Sbjct: 360 SKGFTWGKVYWEVEVEREGWSEDEEEGDEEEEGEEEEEEEEAGYGDGYDDWETDEDEESL 419

Query: 370 GDKTH------------WAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFT 417
           GD+                VGV RDSV RKG+L+  PE G W +RL +   +A  T+P  
Sbjct: 420 GDEEEEEEEEEEEVLESCMVGVARDSVKRKGDLSLRPEDGVWALRLSSSGIWA-NTSPEA 478

Query: 418 PLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWP---LFYPGIR 470
            L   ++P+RVGI LDYE GT++F N   +  IYTFT TFT +L P   L +PG R
Sbjct: 479 ELFPALRPRRVGIALDYEGGTVTFTNAESQELIYTFTATFTRRLVPFLWLKWPGTR 534


>gi|14719418 tripartite motif protein TRIM5 isoform alpha [Homo
           sapiens]
          Length = 493

 Score =  238 bits (607), Expect = 9e-63
 Identities = 159/505 (31%), Positives = 263/505 (52%), Gaps = 57/505 (11%)

Query: 20  LENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERD---FPCPVCRKTSRYR 76
           L N++ E +C +CLE L +P+ ++CGH+FC+AC+T   +    D     CPVCR + +  
Sbjct: 6   LVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRISYQPE 65

Query: 77  SLRPNRQLGSMVEIAKQLQAVKRKIRDESL--CPQHHEALSLFCYEDQEAVCLICAISHT 134
           ++RPNR + ++VE   +L+ VK     + +  C +H E L LFC ED + +C +C  S  
Sbjct: 66  NIRPNRHVANLVE---KLREVKLSPEGQKVDHCARHGEKLLLFCQEDGKVICWLCERSQE 122

Query: 135 HRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQIL 194
           HR H   P ++  QEY+ KLQ  LE L QK QE    ++   ++    K  ++  +  +L
Sbjct: 123 HRGHHTFPTEEVAQEYQVKLQAALEMLRQKQQEAEELEADIREEKASWKTQIQYDKTNVL 182

Query: 195 REFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQS 254
            +FE+L   LD E+   L  LE+EE+DIL+ L  +   +  + + L  L +++E +   S
Sbjct: 183 ADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQTQSLRELISDLEHRLQGS 242

Query: 255 GFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYF------ALRKILKQLI-- 306
             E+L+ V   +++ E        +V+++  + F    R+ F       + ++ ++L   
Sbjct: 243 VMELLQGVDGVIKRTE--------NVTLKKPETFPKNQRRVFRAPDLKGMLEVFRELTDV 294

Query: 307 ----ADVTLDPETAHPNLVLSEDRKSVKFVETRL-----RDLPDTPRRFTFYPCVLATEG 357
                DVT+ P       V+SED++ V   + ++          T   F +   +L ++ 
Sbjct: 295 RRYWVDVTVAPNNI-SCAVISEDKRQVSSPKPQIIYGARGTRYQTFVNFNYCTGILGSQS 353

Query: 358 FTSGRHYWEVEVGDKTHWAVGVCR----DSVS--RKGELTPLPETGYWRVRLWNGDKYAA 411
            TSG+HYWEV+V  KT W +GVC     D++    K E    P+ GYW + L  G K +A
Sbjct: 354 ITSGKHYWEVDVSKKTAWILGVCAGFQPDAMCNIEKNE-NYQPKYGYWVIGLEEGVKCSA 412

Query: 412 --------TTTPF-TPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSH-IYTFTD-TFTEK 460
                    + PF  PL + + P RVG+FLDYEA T+SF+N+T+    IY F+  +F++ 
Sbjct: 413 FQDSSFHTPSVPFIVPLSVIICPDRVGVFLDYEACTVSFFNITNHGFLIYKFSHCSFSQP 472

Query: 461 LWPLFYPGIRAGRKNAAPLTIRPPT 485
           ++P   P     RK   P+T+  P+
Sbjct: 473 VFPYLNP-----RKCGVPMTLCSPS 492


>gi|51477687 tripartite motif protein 34 isoform 1 [Homo sapiens]
          Length = 488

 Score =  236 bits (602), Expect = 3e-62
 Identities = 161/495 (32%), Positives = 260/495 (52%), Gaps = 42/495 (8%)

Query: 20  LENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDF----PCPVCRKTSRY 75
           L N+Q E +C +CLE L EP+ ++CGH+ C+ACIT   ++          CPVC  +  +
Sbjct: 6   LLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSF 65

Query: 76  RSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTH 135
             L+ N+ L ++VE  K+++      +   LC  H E L LFC ED++ +C +C  S  H
Sbjct: 66  EHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCERSQEH 125

Query: 136 RAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILR 195
           R H  V  ++  +E +EKLQ  L+ L+++ +E  + ++   ++    K  V++ RQ+I  
Sbjct: 126 RGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQRIQT 185

Query: 196 EFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSG 255
           EF++L   L+ E+Q  L RLEEEE+  L +  E    L  +++ +  L ++VE +   S 
Sbjct: 186 EFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECRSQWST 245

Query: 256 FEMLKDVKSTLEKCE--KVKTMEVTSVSIELEKNFSNFPRQYFALRKI--LKQLIADVTL 311
            E+L+D+   ++  E  ++K  ++ S  ++   +  +  R     R++  ++    DVTL
Sbjct: 246 MELLQDMSGIMKWSEIWRLKKPKMVSKKLKTVFHAPDLSRMLQMFRELTAVRCYWVDVTL 305

Query: 312 DPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGD 371
           +    + NLVLSED++ V  V       P  P +   Y  VL ++ F+SG+HYWEV+V  
Sbjct: 306 NSVNLNLNLVLSEDQRQVISV-------PIWPFQCYNYG-VLGSQYFSSGKHYWEVDVSK 357

Query: 372 KTHWAVG------------VCRDSVSRKGELTPL-PETGYWRVRLWNGDKYA------AT 412
           KT W +G            V R   +R+   T   P  GYW + L N  KY       ++
Sbjct: 358 KTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYGVFEESLSS 417

Query: 413 TTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDR-SHIYTFTD-TFTEKLWPLFYPGIR 470
                 L + V P RVG+FLDYEAG +SF+NVT   S IY F+   F++ ++P F P   
Sbjct: 418 DPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVYPYFNPW-- 475

Query: 471 AGRKNAAPLTIRPPT 485
                 AP+T+ PP+
Sbjct: 476 ---NCPAPMTLCPPS 487


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,657,532
Number of Sequences: 37866
Number of extensions: 935002
Number of successful extensions: 7663
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 379
Number of HSP's successfully gapped in prelim test: 673
Number of HSP's that attempted gapping in prelim test: 4569
Number of HSP's gapped (non-prelim): 2592
length of query: 488
length of database: 18,247,518
effective HSP length: 106
effective length of query: 382
effective length of database: 14,233,722
effective search space: 5437281804
effective search space used: 5437281804
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.