Search of human proteins with 25777696

Search of human proteins with 25777696

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|25777696 tripartite motif-containing 39 isoform 1 [Homo
sapiens]
         (518 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]  1058   0.0  
gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]   982   0.0  
gi|157743261 tripartite motif-containing 75 [Homo sapiens]            379   e-105
gi|22749269 ring finger protein 129 [Homo sapiens]                    376   e-104
gi|21630277 tripartite motif-containing 11 [Homo sapiens]             359   4e-99
gi|5730009 ret finger protein [Homo sapiens]                          348   5e-96
gi|15208660 tripartite motif protein 21 [Homo sapiens]                344   1e-94
gi|112421127 tripartite motif-containing 58 [Homo sapiens]            323   2e-88
gi|37622899 ring finger protein 137 [Homo sapiens]                    314   1e-85
gi|5454014 tripartite motif-containing 38 [Homo sapiens]              313   3e-85
gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]    309   5e-84
gi|68160933 tripartite motif-containing 17 isoform 1 [Homo sapiens]   308   8e-84
gi|7705825 tripartite motif-containing 17 isoform 1 [Homo sapiens]    308   8e-84
gi|157426898 tripartite motif-containing 10 isoform 1 [Homo sapi...   300   2e-81
gi|31542779 tripartite motif family-like 1 [Homo sapiens]             287   1e-77
gi|68160935 tripartite motif-containing 17 isoform 2 [Homo sapiens]   283   3e-76
gi|42516572 tripartite motif-containing 41 isoform 1 [Homo sapiens]   277   1e-74
gi|51477692 tripartite motif-containing 6 isoform 1 [Homo sapiens]    262   5e-70
gi|18079262 tripartite motif-containing 6 isoform 2 [Homo sapiens]    260   2e-69
gi|4557743 Mediterranean fever protein [Homo sapiens]                 258   1e-68
gi|15011941 tripartite motif protein TRIM4 isoform beta [Homo sa...   257   2e-68
gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens]   257   2e-68
gi|217035095 tripartite motif-containing 62 [Homo sapiens]            247   2e-65
gi|14670266 tripartite motif protein TRIM4 isoform alpha [Homo s...   243   3e-64
gi|4508005 tripartite motif-containing 26 [Homo sapiens]              241   2e-63
gi|157426896 tripartite motif-containing 10 isoform 2 [Homo sapi...   235   6e-62
gi|149193331 tripartite motif protein 15 [Homo sapiens]               234   1e-61
gi|51477690 tripartite motif-containing 6 and tripartite motif-c...   229   4e-60
gi|14719418 tripartite motif protein TRIM5 isoform alpha [Homo s...   228   8e-60
gi|51477687 tripartite motif protein 34 isoform 1 [Homo sapiens]      227   2e-59

>gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]
          Length = 518

 Score = 1058 bits (2736), Expect = 0.0
 Identities = 518/518 (100%), Positives = 518/518 (100%)

Query: 1   MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL 60
           MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL
Sbjct: 1   MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL 60

Query: 61  ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE 120
           ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE
Sbjct: 61  ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE 120

Query: 121 DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG 180
           DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG
Sbjct: 121 DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG 180

Query: 181 ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL 240
           ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL
Sbjct: 181 ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL 240

Query: 241 AHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCE 300
           AHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCE
Sbjct: 241 AHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCE 300

Query: 301 KVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVK 360
           KVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVK
Sbjct: 301 KVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVK 360

Query: 361 FVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGEL 420
           FVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGEL
Sbjct: 361 FVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGEL 420

Query: 421 TPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHI 480
           TPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHI
Sbjct: 421 TPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHI 480

Query: 481 YTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE 518
           YTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
Sbjct: 481 YTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE 518


>gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]
          Length = 488

 Score =  982 bits (2538), Expect = 0.0
 Identities = 488/518 (94%), Positives = 488/518 (94%), Gaps = 30/518 (5%)

Query: 1   MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL 60
           MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL
Sbjct: 1   MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL 60

Query: 61  ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE 120
           ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE
Sbjct: 61  ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE 120

Query: 121 DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG 180
           DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG
Sbjct: 121 DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG 180

Query: 181 ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL 240
           ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL
Sbjct: 181 ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL 240

Query: 241 AHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCE 300
           AHLAAEVEGKCLQSGFEMLKDVKSTLEK                              CE
Sbjct: 241 AHLAAEVEGKCLQSGFEMLKDVKSTLEK------------------------------CE 270

Query: 301 KVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVK 360
           KVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVK
Sbjct: 271 KVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVK 330

Query: 361 FVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGEL 420
           FVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGEL
Sbjct: 331 FVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGEL 390

Query: 421 TPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHI 480
           TPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHI
Sbjct: 391 TPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHI 450

Query: 481 YTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE 518
           YTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
Sbjct: 451 YTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE 488


>gi|157743261 tripartite motif-containing 75 [Homo sapiens]
          Length = 468

 Score =  379 bits (974), Expect = e-105
 Identities = 200/487 (41%), Positives = 289/487 (59%), Gaps = 38/487 (7%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSR 74
           + AAAL  LQ EA CS+CL+YL +PV IECGHNFC++CI + W DL+  FPCPVCR   +
Sbjct: 2   AVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQCQ 61

Query: 75  YRSLRPNRQLGSMVEIAKQLQAVK---RKIRDESLCPQHHEALSLFCYEDQEAVCLICAI 131
               R N QLG M+EIAK LQ+ K   RK  + +LC +H++ LS+FC ED   +C +C  
Sbjct: 62  EGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQ 121

Query: 132 SHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQ 191
              H+ H V P++ A   Y+++    ++PL+++L ++ +  S++ KKP EL+ +VE++RQ
Sbjct: 122 PPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQ 181

Query: 192 QILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKC 251
           ++  EFE L++ LD EQQ +LSRL EEE+D  Q+L  N     +    L    ++V    
Sbjct: 182 ELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELS 241

Query: 252 LQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVS 311
             S  E+L  +K   E                                        +  S
Sbjct: 242 ELSELELLSQIKIFYESE---------------------------------NESSPSIFS 268

Query: 312 IELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPD 371
           I L+++  +FP QY AL++I+K+   ++ LDPETAHPNL++SED+K V+F + R + +P 
Sbjct: 269 IHLKRDGCSFPPQYSALQRIIKKFKVEIILDPETAHPNLIVSEDKKRVRFTK-RKQKVPG 327

Query: 372 TPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRV 431
            P+RFT  P VL    F SGRH+WE+EVGDK+ WA+G+C+DS+  K       +   WR+
Sbjct: 328 FPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKSEWAIGICKDSLPTKARRPSSAQQECWRI 387

Query: 432 RLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKL 491
            L +   +A    P TPL ++VK + +GIFLDYE G +SFYN+ ++SHI TFTDTFT  L
Sbjct: 388 ELQDDGYHAPGAFP-TPLLLEVKARAIGIFLDYEMGEISFYNMAEKSHICTFTDTFTGPL 446

Query: 492 WPLFYPG 498
            P FY G
Sbjct: 447 RPYFYVG 453


>gi|22749269 ring finger protein 129 [Homo sapiens]
          Length = 471

 Score =  376 bits (966), Expect = e-104
 Identities = 205/503 (40%), Positives = 291/503 (57%), Gaps = 41/503 (8%)

Query: 19  ALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSL 78
           AL NLQ E+SC +CLEYLK+PV I CGHNFC++C++  W+DL+  FPCPVCR    Y+S 
Sbjct: 6   ALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCFPYKSF 65

Query: 79  RPNRQLGSMVEIAKQLQ---AVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTH 135
           R N QL ++ EIAKQLQ   + +++ ++ ++C +H++ L+LFC +D E +C  C+ S  H
Sbjct: 66  RRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFSTKH 125

Query: 136 RAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILR 195
           + H + P+  A   ++E L+  LEPL   ++ + +    +  K  ELK+ VE +R++I  
Sbjct: 126 QKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREEINS 185

Query: 196 EFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSG 255
           EFE++   L  EQ+++L ++++EE +IL +L EN   L D    L HL  EVEGK +QS 
Sbjct: 186 EFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSVQSN 245

Query: 256 FEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELE 315
            E+L   KS   K    K        CP                           S  L 
Sbjct: 246 LELLTQAKSMHHKYQNLK--------CPE------------------------LFSFRLT 273

Query: 316 KNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRR 375
           K   + P QY  L +I+K    DV LD  TAHP L++SEDRK+V++ E + R++   PRR
Sbjct: 274 KYGFSLPPQYSGLDRIIKPFQVDVILDLNTAHPQLLVSEDRKAVRY-ERKKRNICYDPRR 332

Query: 376 FTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWN 435
           F   P VL ++ F+SGRHYWEVEVG+K  W +GVC+D + R  +  P    G+W +  + 
Sbjct: 333 FYVCPAVLGSQRFSSGRHYWEVEVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWAIGRYM 392

Query: 436 GDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLF 495
              Y A+    T L   VKP ++GIFLDYE G LSFYN+ DRS +YTF D FTE +WP F
Sbjct: 393 KSGYVASGPKTTQLLPVVKPSKIGIFLDYELGDLSFYNMNDRSILYTFNDCFTEAVWPYF 452

Query: 496 YPGIRAGRKNAAPLTIRPPTDWE 518
           Y G      ++ PL I   +D E
Sbjct: 453 YTG-----TDSEPLKICSVSDSE 470


>gi|21630277 tripartite motif-containing 11 [Homo sapiens]
          Length = 468

 Score =  359 bits (921), Expect = 4e-99
 Identities = 206/479 (43%), Positives = 284/479 (59%), Gaps = 46/479 (9%)

Query: 22  NLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPN 81
           NLQ EA+C++CL+Y  +PV+ +CGHNFC+ CI R W   E  + CP CR+ S  R+LRPN
Sbjct: 9   NLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELSPQRNLRPN 68

Query: 82  RQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVV 141
           R L  M E+A++L         + +CP H E L+ FC ++   +C  C  S  H AH V 
Sbjct: 69  RPLAKMAEMARRLHPPSPV--PQGVCPAHREPLAAFCGDELRLLCAACERSGEHWAHRVR 126

Query: 142 PLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELH 201
           PL DA ++ K KL+K LE L +++Q+    ++  ++     +++VES+RQ +L EFE L 
Sbjct: 127 PLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLGEFERLR 186

Query: 202 RRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKD 261
           R L EE+Q LL RLEEEE ++L RLRE AAHLG +   LA L AE+EG+C      +L+D
Sbjct: 187 RLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPALGLLQD 246

Query: 262 VKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNF 321
           +K  L                               R + VK      V +EL +     
Sbjct: 247 IKDAL------------------------------RRVQDVKLQPPEVVPMEL-RTVCRV 275

Query: 322 PRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPC 381
           P     L + L++   DVTLDP+TA+P L+LSEDR+SV+  + R + LPD+P RF   PC
Sbjct: 276 P----GLVETLRRFRGDVTLDPDTANPELILSEDRRSVQRGDLR-QALPDSPERFDPGPC 330

Query: 382 VLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSR--KGELTPLPETGYWRVRLWNGDKY 439
           VL  E FTSGRHYWEVEVGD+T WA+GVCR++V+R  KGEL+     G+W + ++ G  Y
Sbjct: 331 VLGQERFTSGRHYWEVEVGDRTSWALGVCRENVNRKEKGELS--AGNGFW-ILVFLGSYY 387

Query: 440 AATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTD-TFTEKLWPLFYP 497
            ++     PL  +  P+RVGIFLDYEAG LSFY+ TD S ++ F +  F+  L PLF P
Sbjct: 388 NSSERALAPL--RDPPRRVGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSP 444


>gi|5730009 ret finger protein [Homo sapiens]
          Length = 513

 Score =  348 bits (894), Expect = 5e-96
 Identities = 192/506 (37%), Positives = 293/506 (57%), Gaps = 23/506 (4%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSR 74
           ++ +  E LQ E +C VCL+Y  EP++++CGHN C AC+ R W   E +  CP CR+T  
Sbjct: 2   ASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETFP 61

Query: 75  YRSLRPNRQLGSMVEIAKQLQAVKRKIR--DESLCPQHHEALSLFCYEDQEAVCLICAIS 132
            R +RPNR L ++ ++ KQL+  +      +  +C +H E L L+C EDQ  +C++C  S
Sbjct: 62  QRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRS 121

Query: 133 HTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQ 192
             HR H+V+PL++A + +KE++Q  L+ L++      R ++  E+   EL  L +  R++
Sbjct: 122 REHRGHSVLPLEEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREK 181

Query: 193 ILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCL 252
           I+ EFE+L+  L E +  LL+RLEE +  I   +             L+ L A++E K  
Sbjct: 182 IVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQ 241

Query: 253 QSGFEMLKDVKSTLEK----NIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVT 308
           Q   E+L+D+  TL +     IP  +      I P D +  + +  +       K + +T
Sbjct: 242 QPTRELLQDIGDTLSRAERIRIPEPW------ITPPDLQEKIHIFAQ-------KCLFLT 288

Query: 309 SVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRD 368
               +  +   +   +   LR+     + DVTLDP+TA+P+L+LS++ + V++   + +D
Sbjct: 289 ESLKQFTEKMQSDMEKIQELREAQLYSV-DVTLDPDTAYPSLILSDNLRQVRYSYLQ-QD 346

Query: 369 LPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGY 428
           LPD P RF  +PCVL +  F +GRHYWEVEVGDK  W +GVC DSV RKG +T  P+ G+
Sbjct: 347 LPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGF 406

Query: 429 WRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTD-TF 487
           W V LW G +Y A T+P T L ++   +RVGIFLDY+AG +SFYNVT+R H +TF+  TF
Sbjct: 407 WAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATF 466

Query: 488 TEKLWPLFYPGIRAGRKNAAPLTIRP 513
              + P F     +G K+AAPL I P
Sbjct: 467 CGPVRPYFSLSY-SGGKSAAPLIICP 491


>gi|15208660 tripartite motif protein 21 [Homo sapiens]
          Length = 475

 Score =  344 bits (882), Expect = 1e-94
 Identities = 196/501 (39%), Positives = 288/501 (57%), Gaps = 40/501 (7%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSR 74
           ++AA L  +  E +C +CL+   EPV IECGH+FC+ CI++  +       CPVCR+   
Sbjct: 2   ASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKG--GGSVCPVCRQRFL 59

Query: 75  YRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHT 134
            ++LRPNRQL +MV   K++    R+      C  H E L LFC +D +A+C +CA S  
Sbjct: 60  LKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRK 119

Query: 135 HRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQIL 194
           HR H +VPL++A QEY+EKLQ  L  L +K +   + +     K  + K+ VE+++ +I 
Sbjct: 120 HRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIH 179

Query: 195 REFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQS 254
            EF +    L EE+Q  L  LE++E++ L+ L E  A L  + + L  L +E++ +C  S
Sbjct: 180 AEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSS 239

Query: 255 GFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIEL 314
             E+L++V   LE++                                +K +++TS  +  
Sbjct: 240 ALELLQEVIIVLERS----------------------------ESWNLKDLDITSPEL-- 269

Query: 315 EKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPR 374
            ++  + P     L+K+L+     +TLDP+TA+P L+LSEDR+ V+  +T+ + +P    
Sbjct: 270 -RSVCHVP----GLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQ-QSIPGNEE 323

Query: 375 RFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLW 434
           RF  YP VL  + F SG+HYWEV+V  K  W +GVCRDSV RKG      ++G+W + LW
Sbjct: 324 RFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLW 383

Query: 435 NGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDR-SHIYTFTD-TFTEKLW 492
           N  KY A T P TPLH++V P +VGIFLDYEAG +SFYN+TD  S IY+F++  FT  L 
Sbjct: 384 NKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLR 443

Query: 493 PLFYPGIRAGRKNAAPLTIRP 513
           P F PG   G KN APLT+ P
Sbjct: 444 PFFSPGFNDGGKNTAPLTLCP 464


>gi|112421127 tripartite motif-containing 58 [Homo sapiens]
          Length = 486

 Score =  323 bits (828), Expect = 2e-88
 Identities = 188/499 (37%), Positives = 273/499 (54%), Gaps = 48/499 (9%)

Query: 21  ENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERD----FPCPVCRKTSRYR 76
           E L+ +A C VCL++L+EPV ++CGH+FC  CI+ + E  +      + CP CR   R  
Sbjct: 8   ERLREDARCPVCLDFLQEPVSVDCGHSFCLRCISEFCEKSDGAQGGVYACPQCRGPFRPS 67

Query: 77  SLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHR 136
             RPNRQL  +VE  ++L            C +H E LS FC ED+ A+C +C     HR
Sbjct: 68  GFRPNRQLAGLVESVRRLGLGAGP--GARRCARHGEDLSRFCEEDEAALCWVCDAGPEHR 125

Query: 137 AHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILRE 196
            H   PL +A   Y+ KLQ  LE + ++L++    +++  KK    K  VE +RQ+   E
Sbjct: 126 THRTAPLQEAAGSYQVKLQMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQRFRLE 185

Query: 197 FEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGF 256
           FE+    L +E+Q  L RLE EE+  LQRLRE+ + L  + + L  LA E++ +C +   
Sbjct: 186 FEKHRGFLAQEEQRQLRRLEAEERATLQRLRESKSRLVQQSKALKELADELQERCQRPAL 245

Query: 257 EMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEK 316
            +L+ V+  L                              +R + V  +E  ++ +EL K
Sbjct: 246 GLLEGVRGVL------------------------------SRSKAVTRLEAENIPMEL-K 274

Query: 317 NFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRF 376
                P +    R++L++   DV LDP TAHP+L+L+ D +SV+  E   RD+P+ P RF
Sbjct: 275 TACCIPGR----RELLRKFQVDVKLDPATAHPSLLLTADLRSVQDGEP-WRDVPNNPERF 329

Query: 377 TFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNG 436
             +PC+L  + F+SGRHYWEV VG+   W +GVC+D++ RKGE TP PE G W + L  G
Sbjct: 330 DTWPCILGLQSFSSGRHYWEVLVGEGAEWGLGVCQDTLPRKGETTPSPENGVWALWLLKG 389

Query: 437 DKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFY 496
           ++Y    +P  PL     P+ +GIFLDYEAG +SFYNVTD S+IYTF   F+  L P F+
Sbjct: 390 NEYMVLASPSVPLLQLESPRCIGIFLDYEAGEISFYNVTDGSYIYTFNQLFSGLLRPYFF 449

Query: 497 PGIRAGRKNAAPLTIRPPT 515
                   +A PL + P T
Sbjct: 450 ------ICDATPLILPPTT 462


>gi|37622899 ring finger protein 137 [Homo sapiens]
          Length = 485

 Score =  314 bits (804), Expect = 1e-85
 Identities = 185/510 (36%), Positives = 278/510 (54%), Gaps = 52/510 (10%)

Query: 18  AALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWE----DLERDFPCPVCRKTS 73
           A +E +  E +C +C+ +L+EP+ I+CGH+FC +C++  WE         + CP+CR   
Sbjct: 5   ALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPV 64

Query: 74  RYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISH 133
           + R+LRPN QL ++VE  + L+          LC +H E L +FC ED   +C  C+ S 
Sbjct: 65  QPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSP 124

Query: 134 THRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQI 193
            H AH+VVP++D   EYK +L + LE L+++ +E  + +  E K+    K  VE+R+Q I
Sbjct: 125 EHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSI 184

Query: 194 LREFEEL----------HRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHL 243
           + EFE+           HR+L  E    L+ L+ E  + +Q+L  N + L  + + L  +
Sbjct: 185 VWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRM 244

Query: 244 AAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVK 303
            AE++ +  +    ML+D++  L                              NR +   
Sbjct: 245 IAELKERSQRPVRWMLQDIQEVL------------------------------NRSKSWS 274

Query: 304 TMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVE 363
             +   +S+EL+ +      +   LR+ILK   ADV LDP+TA+  L++SEDRK V + +
Sbjct: 275 LQQPEPISLELKTDC-----RVLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGD 329

Query: 364 TRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPL 423
           T  + LPD P RF  Y  VL ++  +SGRHYWEVEVGD++ W +GVC+ +V RK  +   
Sbjct: 330 TNQK-LPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLS 388

Query: 424 PETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTD-RSHIYT 482
           P  G+W +RL  G++Y A T  +  L + V P+RVGIF+DYEA  +SFYNVTD  SHI+T
Sbjct: 389 PHYGFWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFT 448

Query: 483 FTD-TFTEKLWPLFYPGIRAGRKNAAPLTI 511
           F    F  +L P F P    G  N APL I
Sbjct: 449 FPRYPFPGRLLPYFSPCYSIGTNNTAPLAI 478


>gi|5454014 tripartite motif-containing 38 [Homo sapiens]
          Length = 465

 Score =  313 bits (801), Expect = 3e-85
 Identities = 193/513 (37%), Positives = 275/513 (53%), Gaps = 56/513 (10%)

Query: 11  ASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWED------LERDF 64
           AS  ST   +E    EA+CS+CL  +  PV I CGH++C  CIT ++++       +  F
Sbjct: 2   ASTTSTKKMME----EATCSICLSLMTNPVSINCGHSYCHLCITDFFKNPSQKQLRQETF 57

Query: 65  PCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEA 124
            CP CR      SLRPN+QLGS++E  K+          E  C +H E   LFC ++ + 
Sbjct: 58  CCPQCRAPFHMDSLRPNKQLGSLIEALKETD-------QEMSCEEHGEQFHLFCEDEGQL 110

Query: 125 VCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKR 184
           +C  C  +  H+ HT   ++D  Q YKEKLQK +  L+Q     T  K S   +  + K 
Sbjct: 111 ICWRCERAPQHKGHTTALVEDVCQGYKEKLQKAVTKLKQLEDRCTEQKLSTAMRITKWKE 170

Query: 185 LVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLA 244
            V+ +RQ+I  +F+ L   L EE++  L RLE+EEQ  L RLR+  A LG K  +L    
Sbjct: 171 KVQIQRQKIRSDFKNLQCFLHEEEKSYLWRLEKEEQQTLSRLRDYEAGLGLKSNELKSHI 230

Query: 245 AEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKT 304
            E+E KC  S  ++L++V  TL ++                               K++T
Sbjct: 231 LELEEKCQGSAQKLLQNVNDTLSRSW----------------------------AVKLET 262

Query: 305 MEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVET 364
            E  +VS+EL     N  + YF ++K+L+     VTLDP+TAH  L+LSEDR+ V    T
Sbjct: 263 SE--AVSLELH-TMCNVSKLYFDVKKMLRSHQVSVTLDPDTAHHELILSEDRRQVTRGYT 319

Query: 365 RLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLP 424
           +  +   + RRFT +PCVL  EGFTSGR Y+EV+VG+ T W +GVC ++V R   +   P
Sbjct: 320 Q-ENQDTSSRRFTAFPCVLGCEGFTSGRRYFEVDVGEGTGWDLGVCMENVQRGTGMKQEP 378

Query: 425 ETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFT 484
           ++G+W +RL     Y A T+P T LH+  +P  VGIFLDYEAG +SFYN     HI+TF 
Sbjct: 379 QSGFWTLRLCKKKGYVALTSPPTSLHLHEQPLLVGIFLDYEAGVVSFYNGNTGCHIFTFP 438

Query: 485 D-TFTEKLWPLFYPGIRAGRKNAAPLTIRPPTD 516
             +F++ L P F           +PL + PP D
Sbjct: 439 KASFSDTLRPYFQV------YQYSPLFLPPPGD 465


>gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]
          Length = 511

 Score =  309 bits (791), Expect = 5e-84
 Identities = 193/526 (36%), Positives = 284/526 (53%), Gaps = 78/526 (14%)

Query: 10  GASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERD------ 63
           G  A + A A E LQ EA+CS+CLE  +EPV +ECGH+FC+ACI R WE           
Sbjct: 11  GTGAEALALAAE-LQGEATCSICLELFREPVSVECGHSFCRACIGRCWERPGAGSVGAAT 69

Query: 64  ------FPCPVCRKTSRYRSLRPNRQLGSMVEIAKQL------------QAVKRKIRDES 105
                  PCP CR+ +R   LRPNRQL ++  + ++             QA   +    +
Sbjct: 70  RAPPFPLPCPQCREPARPSQLRPNRQLAAVATLLRRFSLPAAAPGEHGSQAAAARAA-AA 128

Query: 106 LCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKL 165
            C QH E   L+C +D  A+C++C  +  HR H V+PLD+A QE KE L+  L  L+++L
Sbjct: 129 RCGQHGEPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESRLRVLKKEL 188

Query: 166 QEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQR 225
           ++    +S+E+K+  EL + + + ++++  EF+ L   L E++  LL RLEE  +++ Q+
Sbjct: 189 EDCEVFRSTEKKESKELLKQMAAEQEKVGAEFQALRAFLVEQEGRLLGRLEELSREVAQK 248

Query: 226 LRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRD 285
             EN A LG +   L+ L+++++    +   + L++ KSTL                   
Sbjct: 249 QNENLAQLGVEITQLSKLSSQIQETAQKPDLDFLQEFKSTL------------------- 289

Query: 286 HKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADV------ 339
                      +RC  V   + T+VS E++    N   + F L+ +LK+   D+      
Sbjct: 290 -----------SRCSNVPGPKPTTVSSEMKNKVWNVSLKTFVLKGMLKKFKEDLRGELEK 338

Query: 340 ------TLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRH 393
                 TLDP+TA+P L+LS D K V+  E R +DLP+ P RF     VLA+ GF+SGRH
Sbjct: 339 EEKVELTLDPDTANPRLILSLDLKGVRLGE-RAQDLPNHPCRFDTNTRVLASCGFSSGRH 397

Query: 394 YWEVEVGDKTHWAVGVCRDSVSRKGELTPL-PETGYWRVRLWNGDKYAATTTPFTPL--- 449
           +WEVEVG K  WA GV R+SV RKG LTP  PE G W ++L  G  +A T+   +PL   
Sbjct: 398 HWEVEVGSKDGWAFGVARESVRRKG-LTPFTPEEGVWALQLNGGQYWAVTSPERSPLSCG 456

Query: 450 HIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLF 495
           H+     RV + LD E G +SFY V D  H+YTF   F E+++PLF
Sbjct: 457 HL----SRVRVALDLEVGAVSFYAVEDMRHLYTFRVNFQERVFPLF 498


>gi|68160933 tripartite motif-containing 17 isoform 1 [Homo sapiens]
          Length = 477

 Score =  308 bits (789), Expect = 8e-84
 Identities = 181/496 (36%), Positives = 269/496 (54%), Gaps = 66/496 (13%)

Query: 23  LQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL---------ERDFPCPVCRKTS 73
           LQ EA+CS+CL+Y  +PV+  CGHNFC+ACI   WE           +  FPCP CR+ S
Sbjct: 10  LQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMS 69

Query: 74  RYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISH 133
             R+L PNR L  + E+A+Q   +++    + LC +HHE L LFC +DQ  +C++C  S 
Sbjct: 70  PQRNLLPNRLLTKVAEMAQQHPGLQK----QDLCQEHHEPLKLFCQKDQSPICVVCRESR 125

Query: 134 THRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQI 193
            HR H V+P ++A Q YK KL++ +E L +++      ++ EE+   E +  V+ RR++I
Sbjct: 126 EHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERI 185

Query: 194 LREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQ 253
           + EFE+++  L EE+Q LL  LE EE++   RLRE+ A L  +   L  L  ++E +  Q
Sbjct: 186 VLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQLEERSTQ 245

Query: 254 SGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIE 313
              +ML+D+K  L +        ++S  CP           E+    + +T+        
Sbjct: 246 GPLQMLQDMKEPLSRK------NNVSVQCP-----------EVAPPTRPRTV-------- 280

Query: 314 LEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTP 373
                   P Q   LR  L+ ++ D T    +A+P L+L E R+         R L  +P
Sbjct: 281 -----CRVPGQIEVLRGFLEDVVPDAT----SAYPYLLLYESRQR--------RYLGSSP 323

Query: 374 R--------RFTFYPCVLATEGFTSGRHYWEV--EVGDKTHWAVGVCRDSVSRKGELTPL 423
                    RF  YPC +    F+SGRHYWEV   +     WA+GVCRD+VSRK  +   
Sbjct: 324 EGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMNITGDALWALGVCRDNVSRKDRVPKC 383

Query: 424 PETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTF 483
           PE G+W V+L  G KY +T +  TP+ +   P  +GIFLD+EAG +SFY+V+D SH++T+
Sbjct: 384 PENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTY 443

Query: 484 TD-TFTEKLWPLFYPG 498
           +  TF   L P F  G
Sbjct: 444 SQATFPGPLQPFFCLG 459


>gi|7705825 tripartite motif-containing 17 isoform 1 [Homo sapiens]
          Length = 477

 Score =  308 bits (789), Expect = 8e-84
 Identities = 181/496 (36%), Positives = 269/496 (54%), Gaps = 66/496 (13%)

Query: 23  LQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL---------ERDFPCPVCRKTS 73
           LQ EA+CS+CL+Y  +PV+  CGHNFC+ACI   WE           +  FPCP CR+ S
Sbjct: 10  LQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMS 69

Query: 74  RYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISH 133
             R+L PNR L  + E+A+Q   +++    + LC +HHE L LFC +DQ  +C++C  S 
Sbjct: 70  PQRNLLPNRLLTKVAEMAQQHPGLQK----QDLCQEHHEPLKLFCQKDQSPICVVCRESR 125

Query: 134 THRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQI 193
            HR H V+P ++A Q YK KL++ +E L +++      ++ EE+   E +  V+ RR++I
Sbjct: 126 EHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERI 185

Query: 194 LREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQ 253
           + EFE+++  L EE+Q LL  LE EE++   RLRE+ A L  +   L  L  ++E +  Q
Sbjct: 186 VLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQLEERSTQ 245

Query: 254 SGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIE 313
              +ML+D+K  L +        ++S  CP           E+    + +T+        
Sbjct: 246 GPLQMLQDMKEPLSRK------NNVSVQCP-----------EVAPPTRPRTV-------- 280

Query: 314 LEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTP 373
                   P Q   LR  L+ ++ D T    +A+P L+L E R+         R L  +P
Sbjct: 281 -----CRVPGQIEVLRGFLEDVVPDAT----SAYPYLLLYESRQR--------RYLGSSP 323

Query: 374 R--------RFTFYPCVLATEGFTSGRHYWEV--EVGDKTHWAVGVCRDSVSRKGELTPL 423
                    RF  YPC +    F+SGRHYWEV   +     WA+GVCRD+VSRK  +   
Sbjct: 324 EGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMNITGDALWALGVCRDNVSRKDRVPKC 383

Query: 424 PETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTF 483
           PE G+W V+L  G KY +T +  TP+ +   P  +GIFLD+EAG +SFY+V+D SH++T+
Sbjct: 384 PENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTY 443

Query: 484 TD-TFTEKLWPLFYPG 498
           +  TF   L P F  G
Sbjct: 444 SQATFPGPLQPFFCLG 459


>gi|157426898 tripartite motif-containing 10 isoform 1 [Homo
           sapiens]
          Length = 481

 Score =  300 bits (769), Expect = 2e-81
 Identities = 181/500 (36%), Positives = 276/500 (55%), Gaps = 52/500 (10%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWE----DLERDFPCPVCR 70
           ++AA++ +L  E +C +C   L+EPV I+CGHNFC+AC+TR+ E    DLE    CP+C+
Sbjct: 2   ASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLCK 61

Query: 71  KTSRYRSLRPNRQLGSMVEIAKQLQAVKRK-IRDESLCPQHHEALSLFCYEDQEAVCLIC 129
           +  R  S RPN QL ++VE  ++LQ V    + +E +C +H E +  FC +D+  +C++C
Sbjct: 62  EPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCVVC 121

Query: 130 AISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESR 189
             +  H  HT+  L+DA   Y+E++ KCL+ L ++ +EI   +S E K+   L   V ++
Sbjct: 122 REAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVSTK 181

Query: 190 RQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEG 249
           RQQ++ EF  L + L+E+Q +LL++LE ++ DIL++  E    +  +    + L  E+E 
Sbjct: 182 RQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEELEE 241

Query: 250 KCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTS 309
           K  +   E+L D++STL                               RCE  K  +  +
Sbjct: 242 KNERPARELLTDIRSTLI------------------------------RCETRKCRKPVA 271

Query: 310 VSIELEKNFSNFPRQYFALRKILKQLI-----------ADVTLDPETAHPNLVLSEDRKS 358
           VS EL +   +FP+Q   L++ +K  +           A ++LDP+T+HP L+LSED + 
Sbjct: 272 VSPELGQRIRDFPQQALPLQREMKMFLEKLCFELDYEPAHISLDPQTSHPKLLLSEDHQR 331

Query: 359 VKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWA---VGVCRDSVS 415
            +F   + ++ PD P+RF    CVLA  G T GRH W V + D  H     VGV  + V 
Sbjct: 332 AQF-SYKWQNSPDNPQRFDRATCVLAHTGITGGRHTWVVSI-DLAHGGSCTVGVVSEDVQ 389

Query: 416 RKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVT 475
           RKGEL   PE G W VRL  G   A  + P T L +K +P++V + LDYE G ++F N  
Sbjct: 390 RKGELRLRPEEGVWAVRLAWGFVSALGSFP-TRLTLKEQPRQVRVSLDYEVGWVTFTNAV 448

Query: 476 DRSHIYTFTDTFTEKLWPLF 495
            R  IYTFT +FT K+ P F
Sbjct: 449 TREPIYTFTASFTRKVIPFF 468


>gi|31542779 tripartite motif family-like 1 [Homo sapiens]
          Length = 468

 Score =  287 bits (735), Expect = 1e-77
 Identities = 174/503 (34%), Positives = 274/503 (54%), Gaps = 49/503 (9%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSR 74
           STA  +ENL+ E +C +CL+Y   PV  ECGH+FC  C+ R WE+      CP C +T  
Sbjct: 2   STADLMENLREELTCFICLDYFSSPVTTECGHSFCLVCLLRSWEEHNTPLSCPECWRTLE 61

Query: 75  YRSLRPNRQLGSMVEIAKQLQAVKRKIRDES----LCPQHHEALSLFCYEDQEAVCLICA 130
               + N +LG +  IA+QL++   +  DE       P   +ALS    +D++       
Sbjct: 62  GPHFQSNERLGRLASIARQLRSQVLQSEDEQGSYGRMPTTAKALS----DDEQGGSAF-- 115

Query: 131 ISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRR 190
           ++ +H A+ V    +A + ++EKLQ+ L  L  + +E     + E+++    +   ++ +
Sbjct: 116 VAQSHGANRVHLSSEAEEHHREKLQEILNLLRVRRKEAQAVLTHEKERVKLCQEETKTCK 175

Query: 191 QQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGK 250
           Q ++ E+ ++H+ L EE+Q+ L  LE+EE++ +++LR N   L  + R L+ + A++E  
Sbjct: 176 QVVVSEYMKMHQFLKEEEQLQLQLLEQEEKENMRKLRNNEIKLTQQIRSLSKMIAQIESS 235

Query: 251 CLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSV 310
              S FE L++V+  LE++ P                        + +C +  T E++  
Sbjct: 236 SQSSAFESLEEVRGALERSEPL-----------------------LLQCPEATTTELSLC 272

Query: 311 SIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLP 370
            I               ++++L++   ++TLDP TA+  LVLSED KSVK+  +R + LP
Sbjct: 273 RIT-------------GMKEMLRKFSTEITLDPATANAYLVLSEDLKSVKYGGSR-QQLP 318

Query: 371 DTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWR 430
           D P RF     VL T+ FTSGRHYWEVEVG+KT W VG+C+DSVSRKG L   P   +  
Sbjct: 319 DNPERFDQSATVLGTQIFTSGRHYWEVEVGNKTEWEVGICKDSVSRKGNLPKPPGDLFSL 378

Query: 431 VRLWNGDKYAA-TTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTD-TFT 488
           + L  GD Y+   ++P    H++    +VG+FLDYE+G ++FYN TD S IY+F   +F 
Sbjct: 379 IGLKIGDDYSLWVSSPLKGQHVREPVCKVGVFLDYESGHIAFYNGTDESLIYSFPQASFQ 438

Query: 489 EKLWPLFYPGIRAGRKNAAPLTI 511
           E L P+F P +     N  PLTI
Sbjct: 439 EALRPIFSPCLPNEGTNTDPLTI 461


>gi|68160935 tripartite motif-containing 17 isoform 2 [Homo sapiens]
          Length = 450

 Score =  283 bits (723), Expect = 3e-76
 Identities = 170/475 (35%), Positives = 253/475 (53%), Gaps = 66/475 (13%)

Query: 44  CGHNFCKACITRWWEDL---------ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQL 94
           CGHNFC+ACI   WE           +  FPCP CR+ S  R+L PNR L  + E+A+Q 
Sbjct: 4   CGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMSPQRNLLPNRLLTKVAEMAQQH 63

Query: 95  QAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKL 154
             +++    + LC +HHE L LFC +DQ  +C++C  S  HR H V+P ++A Q YK KL
Sbjct: 64  PGLQK----QDLCQEHHEPLKLFCQKDQSPICVVCRESREHRLHRVLPAEEAVQGYKLKL 119

Query: 155 QKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSR 214
           ++ +E L +++      ++ EE+   E +  V+ RR++I+ EFE+++  L EE+Q LL  
Sbjct: 120 EEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERIVLEFEKMNLYLVEEEQRLLQA 179

Query: 215 LEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKF 274
           LE EE++   RLRE+ A L  +   L  L  ++E +  Q   +ML+D+K  L +      
Sbjct: 180 LETEEEETASRLRESVACLDRQGHSLELLLLQLEERSTQGPLQMLQDMKEPLSRK----- 234

Query: 275 GGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQ 334
             ++S  CP           E+    + +T+                P Q   LR  L+ 
Sbjct: 235 -NNVSVQCP-----------EVAPPTRPRTV-------------CRVPGQIEVLRGFLED 269

Query: 335 LIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPR--------RFTFYPCVLATE 386
           ++ D T    +A+P L+L E R+         R L  +P         RF  YPC +   
Sbjct: 270 VVPDAT----SAYPYLLLYESRQR--------RYLGSSPEGSGFCSKDRFVAYPCAVGQT 317

Query: 387 GFTSGRHYWEV--EVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTT 444
            F+SGRHYWEV   +     WA+GVCRD+VSRK  +   PE G+W V+L  G KY +T +
Sbjct: 318 AFSSGRHYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFS 377

Query: 445 PFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTD-TFTEKLWPLFYPG 498
             TP+ +   P  +GIFLD+EAG +SFY+V+D SH++T++  TF   L P F  G
Sbjct: 378 ALTPVMLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLG 432


>gi|42516572 tripartite motif-containing 41 isoform 1 [Homo sapiens]
          Length = 630

 Score =  277 bits (709), Expect = 1e-74
 Identities = 168/470 (35%), Positives = 248/470 (52%), Gaps = 67/470 (14%)

Query: 62  RDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVK---RKIRDESLCPQHHEALSLFC 118
           R F CP CRK+   RS RPN QL +MV++ +Q+        ++ D+ +CP+H EAL LFC
Sbjct: 179 RCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALKLFC 238

Query: 119 YEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKK 178
             D+EA+C++C  S +H+ H+VVPL++  QEYK KLQ  +EPL + L+ + + K+ EE++
Sbjct: 239 EVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERR 298

Query: 179 PGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRR 238
             ELK  ++S    +  EF  L R L EEQ  L  RL E  +  L R    A+ L ++  
Sbjct: 299 VTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAA 358

Query: 239 DLAHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINR 298
            L+ L AE + +  Q G  +L+D+K T                               NR
Sbjct: 359 QLSRLLAEAQERSQQGGLRLLQDIKETF------------------------------NR 388

Query: 299 CEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLI----ADVTLDPETAHPNLVLSE 354
           CE+V+       S +  +  S+       +RK+ +        D+TLDP+TAHP L+LS 
Sbjct: 389 CEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALMLSP 448

Query: 355 DRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSV 414
           DR+ V+  E R +++ D P+RF+   CVL  +GF SGRHYWEVEVG +  WAVG  R+S 
Sbjct: 449 DRRGVRLAERR-QEVADHPKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAAREST 507

Query: 415 SRKGELTP-----------------------LPETGYWRVRLW----NGDKY-AATTTPF 446
             K ++ P                       LP+    +  +W    NG +Y A ++T  
Sbjct: 508 HHKEKVGPGGSSVGSGDASSSRHHHRRRRLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQ 567

Query: 447 TPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFT-EKLWPLF 495
           T L    KP+R G++LDYEAG L FYN    +H++TF+  F  E+++P F
Sbjct: 568 TLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAHVHTFSAAFLGERVFPFF 617



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 23/47 (48%), Positives = 33/47 (70%)

Query: 11 ASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWW 57
          A+ A T   ++ LQ EA C++CL+Y  +PV I CGHNFC+ C+T+ W
Sbjct: 2  AAVAMTPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLW 48


>gi|51477692 tripartite motif-containing 6 isoform 1 [Homo sapiens]
          Length = 516

 Score =  262 bits (670), Expect = 5e-70
 Identities = 178/530 (33%), Positives = 275/530 (51%), Gaps = 56/530 (10%)

Query: 8   EAGAS--AASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL----E 61
           +AGA   A  T+  L +++ E +C +CLE L EP+ I+CGH+FC+ACIT    +     E
Sbjct: 20  QAGARRVATMTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQE 79

Query: 62  RDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYED 121
            +  CPVC+ + +  +LRPNR L ++V   +++     K     LC  H E L LFC ED
Sbjct: 80  GERSCPVCQTSYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQED 139

Query: 122 QEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGE 181
            + +C +C  S  HR H    +++  QEY+EK Q+ L+ L+ + QE  +  +   +K   
Sbjct: 140 GKVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTS 199

Query: 182 LKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLA 241
            K  +E  R +I  EF +L   LD  +Q  L +LE+EE+  L+ + E    L  + + L 
Sbjct: 200 WKNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLR 259

Query: 242 HLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEK 301
            L +++E +C  S  E+L+DV    E++          T+  R  +AL   ++ + R   
Sbjct: 260 ELISDLERRCQGSTMELLQDVSDVTERS-------EFWTL--RKPEALPTKLRSMFRAPD 310

Query: 302 VKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKF 361
           +K M    V  EL                 ++    DVTL+P TA+ NLVL+++R+ V+F
Sbjct: 311 LKRM--LRVCRELTD---------------VQSYWVDVTLNPHTANLNLVLAKNRRQVRF 353

Query: 362 VETRLRDLPDTPRRFTFYPC-VLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGEL 420
           V  ++       +    Y C VL ++ F+SG+HYWEV+V  KT W +GVC +S+      
Sbjct: 354 VGAKVSGPSCLEKH---YDCSVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSF 410

Query: 421 TPL-----------PETGYWRVRLWNGDKYAA--TTTPFTPLHIKVKPKRVGIFLDYEAG 467
                         P++GYW + L +  +Y A   ++P   L + V P+RVG+FLDYEAG
Sbjct: 411 NHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAG 470

Query: 468 TLSFYNVTDRSH-IYTFTD-TFTEKLWPLFYPGIRAGRKNAAPLTIRPPT 515
           T+SFYNVT+    IYTF+   F   L P F P          P+T+R P+
Sbjct: 471 TVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNP-----CNCVIPMTLRRPS 515


>gi|18079262 tripartite motif-containing 6 isoform 2 [Homo sapiens]
          Length = 488

 Score =  260 bits (665), Expect = 2e-69
 Identities = 174/520 (33%), Positives = 270/520 (51%), Gaps = 54/520 (10%)

Query: 16  TAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL----ERDFPCPVCRK 71
           T+  L +++ E +C +CLE L EP+ I+CGH+FC+ACIT    +     E +  CPVC+ 
Sbjct: 2   TSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQT 61

Query: 72  TSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAI 131
           + +  +LRPNR L ++V   +++     K     LC  H E L LFC ED + +C +C  
Sbjct: 62  SYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCER 121

Query: 132 SHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQ 191
           S  HR H    +++  QEY+EK Q+ L+ L+ + QE  +  +   +K    K  +E  R 
Sbjct: 122 SQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERC 181

Query: 192 QILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKC 251
           +I  EF +L   LD  +Q  L +LE+EE+  L+ + E    L  + + L  L +++E +C
Sbjct: 182 RIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRC 241

Query: 252 LQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVS 311
             S  E+L+DV    E++          T+  R  +AL   ++ + R   +K M    V 
Sbjct: 242 QGSTMELLQDVSDVTERS-------EFWTL--RKPEALPTKLRSMFRAPDLKRM--LRVC 290

Query: 312 IELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPD 371
            EL                 ++    DVTL+P TA+ NLVL+++R+ V+FV  ++     
Sbjct: 291 RELTD---------------VQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSC 335

Query: 372 TPRRFTFYPC-VLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPL------- 423
             +    Y C VL ++ F+SG+HYWEV+V  KT W +GVC +S+                
Sbjct: 336 LEKH---YDCSVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAY 392

Query: 424 ----PETGYWRVRLWNGDKYAA--TTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDR 477
               P++GYW + L +  +Y A   ++P   L + V P+RVG+FLDYEAGT+SFYNVT+ 
Sbjct: 393 SRYQPQSGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNH 452

Query: 478 SH-IYTFTD-TFTEKLWPLFYPGIRAGRKNAAPLTIRPPT 515
              IYTF+   F   L P F P          P+T+R P+
Sbjct: 453 GFPIYTFSKYYFPTTLCPYFNP-----CNCVIPMTLRRPS 487


>gi|4557743 Mediterranean fever protein [Homo sapiens]
          Length = 781

 Score =  258 bits (658), Expect = 1e-68
 Identities = 154/413 (37%), Positives = 236/413 (57%), Gaps = 19/413 (4%)

Query: 107 CPQHHEALSL-FCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKL 165
           C +H + + L FC +  E +CLIC++S  H+ H V P+++   E+K+K+QK LE L++  
Sbjct: 375 CKRHLKQVQLLFCEDHDEPICLICSLSQEHQGHRVRPIEEVALEHKKKIQKQLEHLKKLR 434

Query: 166 QEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQR 225
           +     +S  E+K     +  E+ +Q++ R+ E+++  L++++   ++ LE+  Q + Q 
Sbjct: 435 KSGEEQRSYGEEKAVSFLKQTEALKQRVQRKLEQVYYFLEQQEHFFVASLEDVGQMVGQI 494

Query: 226 LRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKN----IPRKFGGSLSTI 281
            +     +      L  L  E+E K  QS +E+L+D+   L +     +P K+       
Sbjct: 495 RKAYDTRVSQDIALLDALIGELEAKECQSEWELLQDIGDILHRAKTVPVPEKW------T 548

Query: 282 CPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTL 341
            P++ K  + L+ + +   + K+ +  S ++  E    N P    A    +     +V L
Sbjct: 549 TPQEIKQKIQLLHQKSEFVE-KSTKYFSETLRSEMEMFNVPELIGAQAHAV-----NVIL 602

Query: 342 DPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGD 401
           D ETA+PNL+ S+D KSV+ +  +   LPD P+RF     VL +  F SGR YWEVEVGD
Sbjct: 603 DAETAYPNLIFSDDLKSVR-LGNKWERLPDGPQRFDSCIIVLGSPSFLSGRRYWEVEVGD 661

Query: 402 KTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIF 461
           KT W +G C+ S+SRKG +T  PE GYW V +   ++Y A++ P T L IK  PKRVGIF
Sbjct: 662 KTAWILGACKTSISRKGNMTLSPENGYWVVIMMKENEYQASSVPPTRLLIKEPPKRVGIF 721

Query: 462 LDYEAGTLSFYNVTDRSHIYTFTD-TFTEKLWPLFYPGIRAGRKNAAPLTIRP 513
           +DY  G++SFYNVT RSHIYTF   +F+  L P+F PG R G KN APLTI P
Sbjct: 722 VDYRVGSISFYNVTARSHIYTFASCSFSGPLQPIFSPGTRDGGKNTAPLTICP 774


>gi|15011941 tripartite motif protein TRIM4 isoform beta [Homo
           sapiens]
          Length = 474

 Score =  257 bits (657), Expect = 2e-68
 Identities = 166/516 (32%), Positives = 244/516 (47%), Gaps = 67/516 (12%)

Query: 21  ENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRP 80
           E++Q E +C +CL+Y ++PV IECGHNFC+ C+ R W      FPCP CR  S   +LRP
Sbjct: 4   EDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPSAPAALRP 63

Query: 81  NRQLGSMVEIAKQLQAVKRKIRD--ESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAH 138
           N  L  + E     +  +R++      LC +H E L LFC +DQ  VCL+C  S  H+ H
Sbjct: 64  NWALARLTE-----KTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQTH 118

Query: 139 TVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFE 198
            + P+D+A + Y+EKL K    L  K++++   +  E K   + K  ++S+R +I  EF 
Sbjct: 119 AMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKSQRMRISTEFS 178

Query: 199 ELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEM 258
           +LH  L EE+ + L RL +EE++  ++L EN   L      L  L  EV  K      E+
Sbjct: 179 KLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEVGEKSQAPTLEL 238

Query: 259 LKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNF 318
           L++ K  L ++  +    SL  +                   KVKT+             
Sbjct: 239 LQNPKEVLTRSEIQDVNYSLEAV-------------------KVKTV------------- 266

Query: 319 SNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVK-----------------F 361
                Q   ++++LK+    V L  +TAHP LV S++ + VK                 F
Sbjct: 267 ----CQIPLMKEMLKRFQVAVNLAEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNYF 322

Query: 362 VETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELT 421
              R         RF   PCVL    FTSG+HYWEVE  D    AVGVCR+ V    + +
Sbjct: 323 AGWRNPQKTAFVERFQHLPCVLGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRS 382

Query: 422 PL-PETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHI 480
            + P+ G W +       +     P TP   +    RVG++LD   G +SFY+  D  H+
Sbjct: 383 KMSPDVGIWAIYWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSFYSAVDGVHL 442

Query: 481 YTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTD 516
           +TF+ +   +L P F+          A L I P TD
Sbjct: 443 HTFSCSSVSRLRPFFW------LSPLASLVIPPVTD 472


>gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens]
          Length = 500

 Score =  257 bits (656), Expect = 2e-68
 Identities = 161/501 (32%), Positives = 256/501 (51%), Gaps = 39/501 (7%)

Query: 20  LENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLR 79
           ++++ +E  C +C ++ ++P+++ CGHNFC+ACI  +W    ++  CP C+   +Y +  
Sbjct: 32  IQDITMELHCPLCNDWFRDPLMLSCGHNFCEACIQDFWRLQAKETFCPECKMLCQYNNCT 91

Query: 80  PNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLIC--AISHTHRA 137
            N  L  +VE  K+L  +K        CP+H E L LF   D + +C  C  A     ++
Sbjct: 92  FNPVLDKLVEKIKKLPLLK----GHPQCPEHGENLKLFSKPDGKLICFQCKDARLSVGQS 147

Query: 138 HTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREF 197
              + + DA   + E+L      LE  L+E+   ++ +++     K      +Q +  EF
Sbjct: 148 KEFLQISDAVHFFTEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQHVSMEF 207

Query: 198 EELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKC-LQSGF 256
            +LH+ L  +++ +L+ L EE + + + +  N + L ++      +   ++ K   Q+ F
Sbjct: 208 LKLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSF 267

Query: 257 EMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEK 316
           + LKD+ + L                   H    G+       + + T E+ S  + L +
Sbjct: 268 DFLKDITTLL-------------------HSLEQGM-------KVLATRELISRKLNLGQ 301

Query: 317 NFSNFPRQYFALRKILKQL---IADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTP 373
                P QY   R++   L   ++ +TLDP+TAHPNLVLS+ + SV   + + + +PD P
Sbjct: 302 YKG--PIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIK-KIMPDDP 358

Query: 374 RRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRL 433
            RF     VL + GFTSG+ YWEVEV  KT W VGV R+S+ RKG     PE G+W +RL
Sbjct: 359 ERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRL 418

Query: 434 WNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWP 493
            N     A   P   L +     +VGI+LDYE G LSFYN    +HIYTF++TF EKL+P
Sbjct: 419 RNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFMEKLYP 478

Query: 494 LFYPGIRAGRKNAAPLTIRPP 514
            F P +  G +N  PL I  P
Sbjct: 479 YFCPCLNDGGENKEPLHILHP 499


>gi|217035095 tripartite motif-containing 62 [Homo sapiens]
          Length = 475

 Score =  247 bits (630), Expect = 2e-65
 Identities = 160/499 (32%), Positives = 246/499 (49%), Gaps = 41/499 (8%)

Query: 22  NLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWW--EDLERDFPCPVCRKTSRYRSLR 79
           +L+ E  CS+CL   ++PV + C H FC+ CIT  W  ++ +    CP CR+T    +L 
Sbjct: 4   SLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEPALA 63

Query: 80  PNRQLGSMVEIAKQ--LQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRA 137
           P+ +L ++VE      L A+    R    C Q H+ + LFC  D+  +C  C     H  
Sbjct: 64  PSLKLANIVERYSSFPLDAILNARRAARPC-QAHDKVKLFCLTDRALLCFFCDEPALHEQ 122

Query: 138 HTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREF 197
           H V  +DDA  E + +L+  L+ L+   +E T      +++  E K   +S R  I   F
Sbjct: 123 HQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAF 182

Query: 198 EELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFE 257
           E LHR L E Q+ +L  LE +    L  + +       + R +            Q G +
Sbjct: 183 ERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKV------------QEGAQ 230

Query: 258 MLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRC-EKVKTMEVTSVSIELEK 316
           +L++  +  +++       SLS       + L G + E N   E   T + T        
Sbjct: 231 ILQERLAETDRHTFLAGVASLS-------ERLKGKIHETNLTYEDFPTSKYTG------- 276

Query: 317 NFSNFPRQYFALRKILKQLI---ADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTP 373
                P QY   + + + +    A +TLDP TAH  L+LS+D   V +     + L D+P
Sbjct: 277 -----PLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSP 331

Query: 374 RRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRL 433
           +RF     VL +E F+SG HYWEV V +KT W +G+  ++ SRKG +   P  G++ + +
Sbjct: 332 KRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVM 391

Query: 434 WNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWP 493
            +G++Y+A T P+T L+++ K  +VG+FLDY+ G L FYN  D S +YTF + F  KL  
Sbjct: 392 HDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCS 451

Query: 494 LFYPG-IRAGRKNAAPLTI 511
            F PG   A  KN  PL I
Sbjct: 452 YFSPGQSHANGKNVQPLRI 470


>gi|14670266 tripartite motif protein TRIM4 isoform alpha [Homo
           sapiens]
          Length = 500

 Score =  243 bits (620), Expect = 3e-64
 Identities = 166/540 (30%), Positives = 242/540 (44%), Gaps = 89/540 (16%)

Query: 21  ENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRP 80
           E++Q E +C +CL+Y ++PV IECGHNFC+ C+ R W      FPCP CR  S   +LRP
Sbjct: 4   EDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPSAPAALRP 63

Query: 81  NRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTV 140
           N  L  + E   + Q  +       LC +H E L LFC +DQ  VCL+C  S  H+ H +
Sbjct: 64  NWALARLTE---KTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQTHAM 120

Query: 141 VPLDDATQEYK--------------------------EKLQKCLEPLEQKLQEITRCKSS 174
            P+D+A + Y+                          EKL K    L  K++++   +  
Sbjct: 121 APIDEAFESYRTGNFDIHVDEWKRRLIRLLLYHSKQEEKLLKSQRNLVAKMKKVMHLQDV 180

Query: 175 EEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLG 234
           E K   + K  ++S+R +I  EF +LH  L EE+ + L RL +EE++  ++L EN   L 
Sbjct: 181 EVKNATQWKDKIKSQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLN 240

Query: 235 DKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVK 294
                L  L  EV  K      E+L++ K  L ++  +    SL  +             
Sbjct: 241 QTIASLKKLILEVGEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEAV------------- 287

Query: 295 EINRCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSE 354
                 KVKT+                  Q   ++++LK+    V L  +TAHP LV S+
Sbjct: 288 ------KVKTV-----------------CQIPLMKEMLKRFQVAVNLAEDTAHPKLVFSQ 324

Query: 355 DRKSVK-----------------FVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEV 397
           + + VK                 F   R         RF   PCVL    FTSG+HYWEV
Sbjct: 325 EGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCVLGKNVFTSGKHYWEV 384

Query: 398 EVGDKTHWAVGVCRDSVSRKGELTPL-PETGYWRVRLWNGDKYAATTTPFTPLHIKVKPK 456
           E  D    AVGVCR+ V    + + + P+ G W +       +     P TP   +    
Sbjct: 385 ESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTPTQQEPALH 444

Query: 457 RVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTD 516
           RVG++LD   G +SFY+  D  H++TF+ +   +L P F+          A L I P TD
Sbjct: 445 RVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSVSRLRPFFW------LSPLASLVIPPVTD 498


>gi|4508005 tripartite motif-containing 26 [Homo sapiens]
          Length = 539

 Score =  241 bits (614), Expect = 2e-63
 Identities = 174/555 (31%), Positives = 274/555 (49%), Gaps = 91/555 (16%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSR 74
           +T+A L +L+ E +CS+CL+YL++PV I+CGH FC++C T           CP+C+K  +
Sbjct: 2   ATSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTTDVRPISGSRPVCPLCKKPFK 61

Query: 75  YRSLRPNRQLGSMVEIAKQLQA--------VKRKIRDESLCPQHHEALSLFCYEDQEAVC 126
             ++RP  QL S+VE  ++L+         V R+ +D  LC +H E L  +C +D + +C
Sbjct: 62  KENIRPVWQLASLVENIERLKVDKGRQPGEVTREQQDAKLCERHREKLHYYCEDDGKLLC 121

Query: 127 LICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLV 186
           ++C  S  HR HT V ++ A Q ++EK+   L  L +   +I   ++  E       + +
Sbjct: 122 VMCRESREHRPHTAVLMEKAAQPHREKILNHLSTLRRDRDKIQGFQAKGEADILAALKKL 181

Query: 187 ESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQ-RLRENAAHLGDKRRDLAHLAA 245
           + +RQ I+ EFE+ H+ L E ++ LL +L + EQ++ + R +  +  +G+  R LA + +
Sbjct: 182 QDQRQYIVAEFEQGHQFLREREEHLLEQLAKLEQELTEGREKFKSRGVGELAR-LALVIS 240

Query: 246 EVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTM 305
           E+EGK  Q   E+++D +  L +   +KF                 + K I R  K KT 
Sbjct: 241 ELEGKAQQPAAELMQDTRDFLNRYPRKKFW----------------VGKPIARVVKKKTG 284

Query: 306 EVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETR 365
           E +   + L++    F  +   L + L+     VTLDP++A   L LSED K V +    
Sbjct: 285 EFSDKLLSLQRGLREFQGK---LLRDLEYKTVSVTLDPQSASGYLQLSEDWKCVTYTSL- 340

Query: 366 LRDLPDTPRRFTFYPCVLATEGFTSGRHY------------------------------- 394
            +     P++F   P VL ++GFT G+ Y                               
Sbjct: 341 YKSAYLHPQQFDCEPGVLGSKGFTWGKVYWEVEVEREGWSEDEEEGDEEEEGEEEEEEEE 400

Query: 395 ---------WEVE-----VGDKTH------------WAVGVCRDSVSRKGELTPLPETGY 428
                    WE +     +GD+                VGV RDSV RKG+L+  PE G 
Sbjct: 401 AGYGDGYDDWETDEDEESLGDEEEEEEEEEEEVLESCMVGVARDSVKRKGDLSLRPEDGV 460

Query: 429 WRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFT 488
           W +RL +   +A  T+P   L   ++P+RVGI LDYE GT++F N   +  IYTFT TFT
Sbjct: 461 WALRLSSSGIWA-NTSPEAELFPALRPRRVGIALDYEGGTVTFTNAESQELIYTFTATFT 519

Query: 489 EKLWP---LFYPGIR 500
            +L P   L +PG R
Sbjct: 520 RRLVPFLWLKWPGTR 534


>gi|157426896 tripartite motif-containing 10 isoform 2 [Homo
           sapiens]
          Length = 395

 Score =  235 bits (600), Expect = 6e-62
 Identities = 136/397 (34%), Positives = 219/397 (55%), Gaps = 47/397 (11%)

Query: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWE----DLERDFPCPVCR 70
           ++AA++ +L  E +C +C   L+EPV I+CGHNFC+AC+TR+ E    DLE    CP+C+
Sbjct: 2   ASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLCK 61

Query: 71  KTSRYRSLRPNRQLGSMVEIAKQLQAVKRK-IRDESLCPQHHEALSLFCYEDQEAVCLIC 129
           +  R  S RPN QL ++VE  ++LQ V    + +E +C +H E +  FC +D+  +C++C
Sbjct: 62  EPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCVVC 121

Query: 130 AISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESR 189
             +  H  HT+  L+DA   Y+E++ KCL+ L ++ +EI   +S E K+   L   V ++
Sbjct: 122 REAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVSTK 181

Query: 190 RQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEG 249
           RQQ++ EF  L + L+E+Q +LL++LE ++ DIL++  E    +  +    + L  E+E 
Sbjct: 182 RQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEELEE 241

Query: 250 KCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTS 309
           K  +   E+L D++STL                               RCE  K  +  +
Sbjct: 242 KNERPARELLTDIRSTLI------------------------------RCETRKCRKPVA 271

Query: 310 VSIELEKNFSNFPRQYFALRKILKQLI-----------ADVTLDPETAHPNLVLSEDRKS 358
           VS EL +   +FP+Q   L++ +K  +           A ++LDP+T+HP L+LSED + 
Sbjct: 272 VSPELGQRIRDFPQQALPLQREMKMFLEKLCFELDYEPAHISLDPQTSHPKLLLSEDHQR 331

Query: 359 VKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYW 395
            +F   + ++ PD P+RF    CVLA  G T GRH W
Sbjct: 332 AQF-SYKWQNSPDNPQRFDRATCVLAHTGITGGRHTW 367


>gi|149193331 tripartite motif protein 15 [Homo sapiens]
          Length = 465

 Score =  234 bits (598), Expect = 1e-61
 Identities = 151/485 (31%), Positives = 242/485 (49%), Gaps = 64/485 (13%)

Query: 28  SCSVCLEYLKEPVIIECGHNFCKACITRWWE----DLERDFPCPVCRKTSRYRSLRPNRQ 83
           +C++C   L++ V I CGH FC+ C+    +       +   CP+C++  +  +      
Sbjct: 15  ACTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLCQEEEQAETPMAPVP 74

Query: 84  LGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPL 143
           LG +                E+ C +H E +  FC  D E +C+ C    TH+AHTV  L
Sbjct: 75  LGPL---------------GETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFL 119

Query: 144 DDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRR 203
           D+A Q Y+++L+  LE L  +  EI   K  E++K   L   +ES++ Q+   FE L + 
Sbjct: 120 DEAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQE 179

Query: 204 LDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVK 263
           L++++ +LL+RL E EQ I +   E    + ++   L     E+E KC Q   E+L+DV+
Sbjct: 180 LEQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQPASELLQDVR 239

Query: 264 STLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNFPR 323
                                            +RCE    +   ++S +L K   +F R
Sbjct: 240 VNQ------------------------------SRCEMKTFVSPEAISPDLVKKIRDFHR 269

Query: 324 QYFALRKILKQLIAD-----------VTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDT 372
           +   L ++++    +           +TLDP+TA  +LVLSEDRKSV++   + + LPD+
Sbjct: 270 KILTLPEMMRMFSENLAHHLEIDSGVITLDPQTASRSLVLSEDRKSVRYTRQK-KSLPDS 328

Query: 373 PRRFTFYPCVLATEGFTSGRHYWEVEV--GDKTHWAVGVCRDSVSRKGELTPLPETGYWR 430
           P RF   P VL   GF+SGRH W+V++  GD     VGV  + V RKGE+    E G W 
Sbjct: 329 PLRFDGLPAVLGFPGFSSGRHRWQVDLQLGDGGGCTVGVAGEGVRRKGEMGLSAEDGVWA 388

Query: 431 VRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEK 490
           V + +   +A+T+ P T L +   P+ V + LDYEAG ++ +N   +  I+TFT +F+ K
Sbjct: 389 VIISHQQCWASTS-PGTDLPLSEIPRGVRVALDYEAGQVTLHNAQTQEPIFTFTASFSGK 447

Query: 491 LWPLF 495
           ++P F
Sbjct: 448 VFPFF 452


>gi|51477690 tripartite motif-containing 6 and tripartite
           motif-containing 34 [Homo sapiens]
          Length = 842

 Score =  229 bits (585), Expect = 4e-60
 Identities = 165/529 (31%), Positives = 264/529 (49%), Gaps = 64/529 (12%)

Query: 12  SAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDF----PCP 67
           S+A  +  L N+Q E +C +CLE L EP+ ++CGH+ C+ACIT   ++          CP
Sbjct: 352 SSAMASKILLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCP 411

Query: 68  VCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCL 127
           VC  +  +  L+ N+ L ++VE  K+++      +   LC  H E L LFC ED++ +C 
Sbjct: 412 VCGISYSFEHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICW 471

Query: 128 ICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVE 187
           +C  S  HR H  V  ++  +E +EKLQ  L+ L+++ +E  + ++   ++    K  V+
Sbjct: 472 LCERSQEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQ 531

Query: 188 SRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEV 247
           + RQ+I  EF++L   L+ E+Q  L RLEEEE+  L +  E    L  +++ +  L ++V
Sbjct: 532 TERQRIQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDV 591

Query: 248 EGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEV 307
           E +   S  E+L+D+   ++ +                         EI R +K K +  
Sbjct: 592 ECRSQWSTMELLQDMSGIMKWS-------------------------EIWRLKKPKMVSK 626

Query: 308 TSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLR 367
              ++    + S   + +  L  +    + DVTL+    + NLVLSED++ V  V     
Sbjct: 627 KLKTVFHAPDLSRMLQMFRELTAVRCYWV-DVTLNSVNLNLNLVLSEDQRQVISV----- 680

Query: 368 DLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVG------------VCRDSVS 415
             P  P +   Y  VL ++ F+SG+HYWEV+V  KT W +G            V R   +
Sbjct: 681 --PIWPFQCYNYG-VLGSQYFSSGKHYWEVDVSKKTAWILGVYCRTYSRHMKYVVRRCAN 737

Query: 416 RKGELTPL-PETGYWRVRLWNGDKYA------ATTTPFTPLHIKVKPKRVGIFLDYEAGT 468
           R+   T   P  GYW + L N  KY       ++      L + V P RVG+FLDYEAG 
Sbjct: 738 RQNLYTKYRPLFGYWVIGLQNKCKYGVFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGI 797

Query: 469 LSFYNVTDR-SHIYTFTD-TFTEKLWPLFYPGIRAGRKNAAPLTIRPPT 515
           +SF+NVT   S IY F+   F++ ++P F P         AP+T+ PP+
Sbjct: 798 VSFFNVTSHGSLIYKFSKCCFSQPVYPYFNPW-----NCPAPMTLCPPS 841



 Score =  162 bits (410), Expect = 7e-40
 Identities = 92/268 (34%), Positives = 147/268 (54%), Gaps = 6/268 (2%)

Query: 8   EAGAS--AASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL----E 61
           +AGA   A  T+  L +++ E +C +CLE L EP+ I+CGH+FC+ACIT    +     E
Sbjct: 20  QAGARRVATMTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQE 79

Query: 62  RDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYED 121
            +  CPVC+ + +  +LRPNR L ++V   +++     K     LC  H E L LFC ED
Sbjct: 80  GERSCPVCQTSYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQED 139

Query: 122 QEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGE 181
            + +C +C  S  HR H    +++  QEY+EK Q+ L+ L+ + QE  +  +   +K   
Sbjct: 140 GKVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTS 199

Query: 182 LKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLA 241
            K  +E  R +I  EF +L   LD  +Q  L +LE+EE+  L+ + E    L  + + L 
Sbjct: 200 WKNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLR 259

Query: 242 HLAAEVEGKCLQSGFEMLKDVKSTLEKN 269
            L +++E +C  S  E+L+DV    E++
Sbjct: 260 ELISDLERRCQGSTMELLQDVSDVTERS 287


>gi|14719418 tripartite motif protein TRIM5 isoform alpha [Homo
           sapiens]
          Length = 493

 Score =  228 bits (582), Expect = 8e-60
 Identities = 158/523 (30%), Positives = 263/523 (50%), Gaps = 63/523 (12%)

Query: 20  LENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERD---FPCPVCRKTSRYR 76
           L N++ E +C +CLE L +P+ ++CGH+FC+AC+T   +    D     CPVCR + +  
Sbjct: 6   LVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRISYQPE 65

Query: 77  SLRPNRQLGSMVEIAKQLQAVKRKIRDESL--CPQHHEALSLFCYEDQEAVCLICAISHT 134
           ++RPNR + ++VE   +L+ VK     + +  C +H E L LFC ED + +C +C  S  
Sbjct: 66  NIRPNRHVANLVE---KLREVKLSPEGQKVDHCARHGEKLLLFCQEDGKVICWLCERSQE 122

Query: 135 HRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQIL 194
           HR H   P ++  QEY+ KLQ  LE L QK QE    ++   ++    K  ++  +  +L
Sbjct: 123 HRGHHTFPTEEVAQEYQVKLQAALEMLRQKQQEAEELEADIREEKASWKTQIQYDKTNVL 182

Query: 195 REFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQS 254
            +FE+L   LD E+   L  LE+EE+DIL+ L  +   +  + + L  L +++E +   S
Sbjct: 183 ADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQTQSLRELISDLEHRLQGS 242

Query: 255 GFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIEL 314
             E+L+ V   +++            +  +  +      + + R   +K M      +E+
Sbjct: 243 VMELLQGVDGVIKRT---------ENVTLKKPETFPKNQRRVFRAPDLKGM------LEV 287

Query: 315 EKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRL-----RDL 369
            +  ++  R +            DVT+ P       V+SED++ V   + ++        
Sbjct: 288 FRELTDVRRYW-----------VDVTVAPNNISC-AVISEDKRQVSSPKPQIIYGARGTR 335

Query: 370 PDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCR----DSVS--RKGELTPL 423
             T   F +   +L ++  TSG+HYWEV+V  KT W +GVC     D++    K E    
Sbjct: 336 YQTFVNFNYCTGILGSQSITSGKHYWEVDVSKKTAWILGVCAGFQPDAMCNIEKNE-NYQ 394

Query: 424 PETGYWRVRLWNGDKYAA--------TTTPF-TPLHIKVKPKRVGIFLDYEAGTLSFYNV 474
           P+ GYW + L  G K +A         + PF  PL + + P RVG+FLDYEA T+SF+N+
Sbjct: 395 PKYGYWVIGLEEGVKCSAFQDSSFHTPSVPFIVPLSVIICPDRVGVFLDYEACTVSFFNI 454

Query: 475 TDRSH-IYTFTD-TFTEKLWPLFYPGIRAGRKNAAPLTIRPPT 515
           T+    IY F+  +F++ ++P   P     RK   P+T+  P+
Sbjct: 455 TNHGFLIYKFSHCSFSQPVFPYLNP-----RKCGVPMTLCSPS 492


>gi|51477687 tripartite motif protein 34 isoform 1 [Homo sapiens]
          Length = 488

 Score =  227 bits (578), Expect = 2e-59
 Identities = 163/521 (31%), Positives = 260/521 (49%), Gaps = 64/521 (12%)

Query: 20  LENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDF----PCPVCRKTSRY 75
           L N+Q E +C +CLE L EP+ ++CGH+ C+ACIT   ++          CPVC  +  +
Sbjct: 6   LLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSF 65

Query: 76  RSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTH 135
             L+ N+ L ++VE  K+++      +   LC  H E L LFC ED++ +C +C  S  H
Sbjct: 66  EHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCERSQEH 125

Query: 136 RAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILR 195
           R H  V  ++  +E +EKLQ  L+ L+++ +E  + ++   ++    K  V++ RQ+I  
Sbjct: 126 RGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQRIQT 185

Query: 196 EFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSG 255
           EF++L   L+ E+Q  L RLEEEE+  L +  E    L  +++ +  L ++VE +   S 
Sbjct: 186 EFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECRSQWST 245

Query: 256 FEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELE 315
            E+L+D+   ++ +                         EI R +K K +     ++   
Sbjct: 246 MELLQDMSGIMKWS-------------------------EIWRLKKPKMVSKKLKTVFHA 280

Query: 316 KNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRR 375
            + S   + +  L  +    + DVTL+    + NLVLSED++ V  V       P  P +
Sbjct: 281 PDLSRMLQMFRELTAVRCYWV-DVTLNSVNLNLNLVLSEDQRQVISV-------PIWPFQ 332

Query: 376 FTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVG------------VCRDSVSRKGELTPL 423
              Y  VL ++ F+SG+HYWEV+V  KT W +G            V R   +R+   T  
Sbjct: 333 CYNYG-VLGSQYFSSGKHYWEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKY 391

Query: 424 -PETGYWRVRLWNGDKYA------ATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTD 476
            P  GYW + L N  KY       ++      L + V P RVG+FLDYEAG +SF+NVT 
Sbjct: 392 RPLFGYWVIGLQNKCKYGVFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTS 451

Query: 477 R-SHIYTFTD-TFTEKLWPLFYPGIRAGRKNAAPLTIRPPT 515
             S IY F+   F++ ++P F P         AP+T+ PP+
Sbjct: 452 HGSLIYKFSKCCFSQPVYPYFNPW-----NCPAPMTLCPPS 487


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,842,213
Number of Sequences: 37866
Number of extensions: 989136
Number of successful extensions: 7736
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 377
Number of HSP's successfully gapped in prelim test: 646
Number of HSP's that attempted gapping in prelim test: 4704
Number of HSP's gapped (non-prelim): 2653
length of query: 518
length of database: 18,247,518
effective HSP length: 107
effective length of query: 411
effective length of database: 14,195,856
effective search space: 5834496816
effective search space used: 5834496816
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.