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Search of human proteins with 12083581
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12083581 phosphoinositide-specific phospholipase C beta 1
isoform a [Homo sapiens]
(1216 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 2420 0.0
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 2271 0.0
gi|11386139 phospholipase C beta 3 [Homo sapiens] 1307 0.0
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 1075 0.0
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 822 0.0
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 820 0.0
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 342 1e-93
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 332 2e-90
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 332 2e-90
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 328 2e-89
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 328 2e-89
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 326 9e-89
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 326 9e-89
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 318 2e-86
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 312 1e-84
gi|19115964 phospholipase C delta 3 [Homo sapiens] 307 3e-83
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 187 4e-47
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 174 5e-43
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 174 5e-43
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 174 5e-43
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 164 4e-40
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 164 4e-40
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 157 4e-38
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 68 5e-11
gi|28460688 taxilin [Homo sapiens] 67 1e-10
gi|239745081 PREDICTED: similar to Golgin subfamily A member 8-l... 66 2e-10
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 64 7e-10
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo... 64 7e-10
gi|239745085 PREDICTED: similar to Golgin subfamily A member 8-l... 63 1e-09
gi|148746195 trichohyalin [Homo sapiens] 62 3e-09
>gi|12083581 phosphoinositide-specific phospholipase C beta 1 isoform
a [Homo sapiens]
Length = 1216
Score = 2420 bits (6272), Expect = 0.0
Identities = 1216/1216 (100%), Positives = 1216/1216 (100%)
Query: 1 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE 60
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
Sbjct: 1 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE 60
Query: 61 TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV 120
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV
Sbjct: 61 TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV 120
Query: 121 AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA 180
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
Sbjct: 121 AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA 180
Query: 181 DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL 240
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
Sbjct: 181 DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL 240
Query: 241 TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS 300
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS
Sbjct: 241 TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS 300
Query: 301 GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV 360
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
Sbjct: 301 GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV 360
Query: 361 ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ 420
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
Sbjct: 361 ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ 420
Query: 421 QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK 480
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
Sbjct: 421 QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK 480
Query: 481 KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM 540
KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
Sbjct: 481 KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM 540
Query: 541 SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK 600
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
Sbjct: 541 SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK 600
Query: 601 GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK 660
GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
Sbjct: 601 GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK 660
Query: 661 HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG 720
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
Sbjct: 661 HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG 720
Query: 721 NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER 780
NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
Sbjct: 721 NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER 780
Query: 781 NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK 840
NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
Sbjct: 781 NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK 840
Query: 841 EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS 900
EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
Sbjct: 841 EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS 900
Query: 901 VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL 960
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
Sbjct: 901 VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL 960
Query: 961 RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR 1020
RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
Sbjct: 961 RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR 1020
Query: 1021 QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI 1080
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
Sbjct: 1021 QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI 1080
Query: 1081 TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP 1140
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
Sbjct: 1081 TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP 1140
Query: 1141 KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSS 1200
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSS
Sbjct: 1141 KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSS 1200
Query: 1201 EELGGDIPGKEFDTPL 1216
EELGGDIPGKEFDTPL
Sbjct: 1201 EELGGDIPGKEFDTPL 1216
>gi|33356544 phosphoinositide-specific phospholipase C beta 1 isoform
b [Homo sapiens]
Length = 1173
Score = 2271 bits (5886), Expect = 0.0
Identities = 1141/1141 (100%), Positives = 1141/1141 (100%)
Query: 1 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE 60
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
Sbjct: 1 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE 60
Query: 61 TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV 120
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV
Sbjct: 61 TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV 120
Query: 121 AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA 180
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
Sbjct: 121 AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA 180
Query: 181 DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL 240
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
Sbjct: 181 DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL 240
Query: 241 TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS 300
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS
Sbjct: 241 TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS 300
Query: 301 GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV 360
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
Sbjct: 301 GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV 360
Query: 361 ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ 420
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
Sbjct: 361 ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ 420
Query: 421 QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK 480
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
Sbjct: 421 QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK 480
Query: 481 KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM 540
KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
Sbjct: 481 KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM 540
Query: 541 SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK 600
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
Sbjct: 541 SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK 600
Query: 601 GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK 660
GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
Sbjct: 601 GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK 660
Query: 661 HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG 720
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
Sbjct: 661 HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG 720
Query: 721 NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER 780
NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
Sbjct: 721 NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER 780
Query: 781 NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK 840
NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
Sbjct: 781 NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK 840
Query: 841 EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS 900
EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
Sbjct: 841 EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS 900
Query: 901 VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL 960
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
Sbjct: 901 VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL 960
Query: 961 RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR 1020
RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
Sbjct: 961 RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR 1020
Query: 1021 QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI 1080
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
Sbjct: 1021 QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI 1080
Query: 1081 TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP 1140
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
Sbjct: 1081 TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP 1140
Query: 1141 K 1141
K
Sbjct: 1141 K 1141
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 1307 bits (3383), Expect = 0.0
Identities = 683/1269 (53%), Positives = 887/1269 (69%), Gaps = 88/1269 (6%)
Query: 1 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE 60
MAGAQPGVHALQL+P V ++L++G+KF+KWD++++ + LR DP GFF YWT N E
Sbjct: 1 MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNME 60
Query: 61 TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNI-GRLEQRMITVVYGPDLVNISHLNL 119
+ LD+S ++D R GR+A+ PKDPK+RE+L G RLE++++TVV GPD VN LN
Sbjct: 61 VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF 120
Query: 120 VAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFS 179
+A Q++ AK W+ E+F LA N+LAQN SR+ FL KAYTKLKLQV +GRIP+KNI ++FS
Sbjct: 121 MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS 180
Query: 180 ADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPY 239
AD+KRVETALE+C L +R++SI ++F+ E++ FLN LC RP+ID I E GAK KPY
Sbjct: 181 ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY 240
Query: 240 LTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYL 299
LT++Q+MDFIN KQRDPRLNE+LYPPL+ Q ++LIEKYEPN + Q+S++GF RYL
Sbjct: 241 LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL 300
Query: 300 SGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRC 359
GEENG++ E LDL+ DM+QPLS YFINSSHNTYLTAGQLAG SSVEMYRQ LL GCRC
Sbjct: 301 GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC 360
Query: 360 VELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPK 419
VELD WKGR EEEP ITHGFTMTTE+ ++V+EAIAE AFKTSP+P++LSFENHVDS K
Sbjct: 361 VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK 420
Query: 420 QQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEG--- 476
QQAKMAEYCR IFGDALL+EPL+KYPL GVPLPSP DLM +ILVKNKK+ S+ G
Sbjct: 421 QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDS 480
Query: 477 SGKKKLSEQASNTYSDSSSMFEPSSPGAGE------------------------------ 506
+G+K+ EQ+++ S+SS+ EPSSP G
Sbjct: 481 AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGD 540
Query: 507 ------------ADTESDDDDDDD----DCKKSSMDEGTAGSEAMATEEMSNLVNYIQPV 550
AD E +++D+++ D KK + DEGTA SE ATEEMS LVNYI+PV
Sbjct: 541 EGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV 600
Query: 551 KFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYM 610
KF+SFE ++KRNK FEMSSFVETK +EQLTKSP+EFVEYNK QLSRIYPKGTRVDSSNYM
Sbjct: 601 KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM 660
Query: 611 PQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIV 670
PQLFWN GCQ+VALNFQT+D+AMQ+N G++EYNG+SGY LKPEFMRRPDK FDPFTE IV
Sbjct: 661 PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV 720
Query: 671 DGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEE 730
DGIVAN L VK+ISGQFLSD+KVG YVEVDMFGLPVDTRRK ++T+TSQGN+ NPVW+EE
Sbjct: 721 DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRK-YRTRTSQGNSFNPVWDEE 779
Query: 731 PIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVF 790
P F KVVLPTLA LRIA +EEGGKF+GHRILPV AIR GYHY+CLRNE NQPL LPA+
Sbjct: 780 PFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALL 839
Query: 791 VYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSE 850
+Y E DY+PD + D EAL NPI++V+LM+QRA+QLAAL E E + +E +
Sbjct: 840 IYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQ 899
Query: 851 APSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTI 910
S+ + P + ++ + P P + PA S+ +P + +DLI S+L+EV +
Sbjct: 900 LGSQPSSNPTPSPLDASPRRPPGPT-----TSPASTSLSSPGQRDDLIASILSEVAPTPL 954
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQND--YLRRRAALEK 968
+EL+ K+ VKL+ + +++++L K+H +K L + + Q + R AL
Sbjct: 955 DELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGG 1014
Query: 969 SAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEK 1028
+A + K+ E + ++ + +++Q Q LL LR+ Q +E
Sbjct: 1015 AADVEDTKEGE--------------------DEAKRYQEFQNRQVQSLLELREAQVDAEA 1054
Query: 1029 YQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDK 1088
++ EH++ +Q+L +V + Q K+LKE+ E+EKKEL+K +D+KR I+EAK +DK
Sbjct: 1055 QRRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDK 1114
Query: 1089 SQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQ 1148
+ E E TE+ R +I E V I+RLEEAQ +R ++LV +++ QQ+ +E+PKL +L Q
Sbjct: 1115 HKKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQ 1174
Query: 1149 EYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSSEEL-GGDI 1207
E Q++ RLP EI + ++ G++ E G PL + G H SS L G D
Sbjct: 1175 ECQEQRARLPQEI----RRSLLGEMPE--GLGDGPLVACASNG---HAPGSSGHLSGADS 1225
Query: 1208 PGKEFDTPL 1216
+E +T L
Sbjct: 1226 ESQEENTQL 1234
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 1075 bits (2781), Expect = 0.0
Identities = 562/1177 (47%), Positives = 779/1177 (66%), Gaps = 56/1177 (4%)
Query: 13 LKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDA 72
L P V L +G +F+KWDD++T+ +P+ILR DP+G++ YWT Q+KE E LD++ ++D
Sbjct: 8 LLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDT 67
Query: 73 RCGRHAKAPKDPKLRELLDVG-NIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWT 131
R G+ AK PK KLR++ ++ + +TVV GPD+V+++ N V+++E V K W
Sbjct: 68 RFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWA 127
Query: 132 NEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEA 191
+V +L + L N SR FL+K KLK+Q+ EG+IP+KN +++F ADRKRVE AL A
Sbjct: 128 EDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSA 187
Query: 192 CSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINL 251
C LP +ND+I EDF VY+ FL +LCPRPEID IF+ + AK+KPY+T + + FIN
Sbjct: 188 CHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQ 247
Query: 252 KQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEK 311
KQRD RLN +L+PP + +QVQ LI+KYEP+ A++GQ+S +G + +L G EN V++ +K
Sbjct: 248 KQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDK 307
Query: 312 LDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAE 371
L L+ DM+QPL+HYFINSSHNTYLTAGQ +G SS EMYRQVLLSGCRCVELDCWKG+ +
Sbjct: 308 LLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPD 367
Query: 372 EEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLI 431
EEP+ITHGFTMTT+I FKE IEAIAE AFKTSP+PI+LSFENHVDSP+QQAKMAEYCR I
Sbjct: 368 EEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTI 427
Query: 432 FGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYS 491
FGD LL EPLEK+PL+ GVPLPSP DL KIL+KNKK ++ SG S+
Sbjct: 428 FGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKK-----NQFSGPTSSSKDTGGEAE 482
Query: 492 DSSSMFEPSSPG---AGEADTESDDDD------------DDDDCKKSSMDEGTAGSEAMA 536
SS P+ G AGE TE ++++ D+++ KK DEGTAG E A
Sbjct: 483 GSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTA 542
Query: 537 TEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSR 596
EEMS+LVNYIQP KF SFE S ++N+S+ +SSF E K + L+K+ V+FV+YNK Q+SR
Sbjct: 543 YEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSR 602
Query: 597 IYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMR 656
IYPKGTR+DSSNYMPQ+FWNAGCQMVALNFQTMDL MQ NM ++E+NG+SGY LK EFMR
Sbjct: 603 IYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMR 662
Query: 657 RPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTK 716
RPDK F+PF+ +D +VA TLS+ +ISGQFLS++ V TYVEV++FGLP D +R+ ++TK
Sbjct: 663 RPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRR-YRTK 721
Query: 717 TSQG-NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYIC 775
S N++NPVW+EEP VF+K+++P LA LR+AV EEG KF+GHRI+P+ A+ GYH++C
Sbjct: 722 LSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLC 781
Query: 776 LRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDE 835
L +E N PLT+PA+F+++E+KDY+P +AD+ AL+NPI++ + + ++ +L
Sbjct: 782 LHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKL-------- 833
Query: 836 EEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTE 895
KEA G P + NG L P + GS A A
Sbjct: 834 ----KEAMGGLPEKPFPLASPVASQVNG-----ALAP----------TSNGSPAARAGAR 874
Query: 896 DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEI 955
+ E ++EEL++ K VKLQ++H KE+++L +R ++ +L++ + E+
Sbjct: 875 EEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAEL 934
Query: 956 QNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQ 1015
+ A + K S+KK + + + +D ++ +LKD+ + +
Sbjct: 935 GPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDG----RVRELKDRLELE 990
Query: 1016 LLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKK 1075
LL +EQY +K +H+ I K+ ++A E Q +LK LKE E + KE+KKK++ K
Sbjct: 991 LLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETK 1050
Query: 1076 RQEKI--TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQ 1133
R E+I + DK E K E+ S+IQEVVQ IK++ E + QEKL EK +
Sbjct: 1051 RLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLE 1110
Query: 1134 QILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMK 1170
QI + + + Q E EY+ + K L E+ E V+ ++
Sbjct: 1111 QIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLR 1147
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 822 bits (2124), Expect = 0.0
Identities = 475/1184 (40%), Positives = 694/1184 (58%), Gaps = 82/1184 (6%)
Query: 18 VSDSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGR 76
V L++GT F +++++S + P + + D GFF W + KE ++L+ SL+ R G
Sbjct: 13 VPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGA 72
Query: 77 HAKAPKDPKLRELLDVGNIGR----LEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTN 132
PKDPK+ L+ +G+ LE R++ V G DLVNIS +VA EV K+W
Sbjct: 73 ---IPKDPKILAALEA--VGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVE 127
Query: 133 EVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADR--KRVETALE 190
+ S+ N A N+S L+K + KL G+IP+++I R F++ + K + AL+
Sbjct: 128 GLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALK 187
Query: 191 ACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFIN 250
LPS +ND I F+ E + +CPR +I+++F + YLTVDQ++ F+N
Sbjct: 188 ELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLN 247
Query: 251 LKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPE 310
QRDPRLNEIL+P ++ +IE YEP+ L +KG IS DGF RYL +EN V +
Sbjct: 248 EHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLD 307
Query: 311 KLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTA 370
+L+L ++M PL+HYFI+SSHNTYLT Q G SSVEMYRQVLL+GCRCVELDCW G+
Sbjct: 308 RLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGE 367
Query: 371 EEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRL 430
++EP+ITHG M T+I FK+VI+AI E AF TS +P++LSFENH S QQ KM++YC
Sbjct: 368 DQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHC-SKYQQYKMSKYCED 426
Query: 431 IFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKK--------------KSHKSSEG 476
+FGD LL + LE +PLE G LPSP DL KIL+KNK+ ++ E
Sbjct: 427 LFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGES 486
Query: 477 SGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTA------ 530
+ + E + +S+ E + P + S DD + +S+ +G
Sbjct: 487 ASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQ 546
Query: 531 ---------GSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTK 581
G+ +S ++NY QPVKF+ F ++++RN + MSSF E+ GL L
Sbjct: 547 AWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKT 606
Query: 582 SPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYE 641
+EFV YNK Q+SRIYPKG RVDSSNYMPQ+FWNAGCQMV+LN+QT DLAMQ+N G +E
Sbjct: 607 HAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFE 666
Query: 642 YNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDM 701
YNG GY LKP+FMRRPD+ FDPF+E VDG++A T SV++ISGQFLSDKK+GTYVEVDM
Sbjct: 667 YNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDM 726
Query: 702 FGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRI 761
+GLP DT RK F+T+ N +NPV+ EE VF+KV+LP LA LRIAVY++ K IG RI
Sbjct: 727 YGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRI 786
Query: 762 LPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLME 821
LP+ ++ GY +I LRNE N+PL+LP +F I +K YVPD + D+++ALS+P +++++ E
Sbjct: 787 LPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITE 846
Query: 822 QRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHS 881
+RA Q+ A+ +E +D + PS+ + A +TP+ S+ +
Sbjct: 847 KRADQMRAMGIE-------TSDIADVPSDTSKNDKKGKANTA---KANVTPQSSSELRPT 896
Query: 882 QPAPGSVKAPAKTE-DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKK 940
A + AK +LI V IE+LKQ K+++K KK KE+ L K+H K+
Sbjct: 897 TTAALASGVEAKKGIELIPQV-------RIEDLKQMKAYLKHLKKQQKELNSLKKKHAKE 949
Query: 941 TTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIE--------- 991
+ + K H T+ ++I Y + ++ EK +K KKK GS+ +E
Sbjct: 950 HSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKG-------GSNCLEMKKETEIKI 1002
Query: 992 QDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQN 1051
Q L + ++++ K+ +++N + + L++KL A E Q
Sbjct: 1003 QTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQT 1062
Query: 1052 NQLKKLKEICEKEKKELKKKMDKKRQEKITEAKS-KDKSQMEEEKTEMIRSYIQEVVQYI 1110
QLK + KE + + K+ + + I++ KS K+K++ E E+ S ++ ++
Sbjct: 1063 QQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEER 1122
Query: 1111 KRLEEAQSKRQEKLVE---KHKEIRQQILDEKPKLQ--VELEQE 1149
KRL QSK ++L + +H E ++ ++ ++Q V+LE E
Sbjct: 1123 KRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQAKEMQQMVKLEAE 1166
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 820 bits (2117), Expect = 0.0
Identities = 468/1154 (40%), Positives = 678/1154 (58%), Gaps = 77/1154 (6%)
Query: 18 VSDSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGR 76
V L++GT F +++++S + P + + D GFF W + KE ++L+ SL+ R G
Sbjct: 13 VPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGA 72
Query: 77 HAKAPKDPKLRELLDVGNIGR----LEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTN 132
PKDPK+ L+ +G+ LE R++ V G DLVNIS +VA EV K+W
Sbjct: 73 ---IPKDPKILAALEA--VGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVE 127
Query: 133 EVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADR--KRVETALE 190
+ S+ N A N+S L+K + KL G+IP+++I R F++ + K + AL+
Sbjct: 128 GLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALK 187
Query: 191 ACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFIN 250
LPS +ND I F+ E + +CPR +I+++F + YLTVDQ++ F+N
Sbjct: 188 ELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLN 247
Query: 251 LKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPE 310
QRDPRLNEIL+P ++ +IE YEP+ L +KG IS DGF RYL +EN V +
Sbjct: 248 EHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLD 307
Query: 311 KLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTA 370
+L+L ++M PL+HYFI+SSHNTYLT Q G SSVEMYRQVLL+GCRCVELDCW G+
Sbjct: 308 RLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGE 367
Query: 371 EEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRL 430
++EP+ITHG M T+I FK+VI+AI E AF TS +P++LSFENH S QQ KM++YC
Sbjct: 368 DQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHC-SKYQQYKMSKYCED 426
Query: 431 IFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKK--------------KSHKSSEG 476
+FGD LL + LE +PLE G LPSP DL KIL+KNK+ ++ E
Sbjct: 427 LFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGES 486
Query: 477 SGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTA------ 530
+ + E + +S+ E + P + S DD + +S+ +G
Sbjct: 487 ASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQ 546
Query: 531 ---------GSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTK 581
G+ +S ++NY QPVKF+ F ++++RN + MSSF E+ GL L
Sbjct: 547 AWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKT 606
Query: 582 SPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYE 641
+EFV YNK Q+SRIYPKG RVDSSNYMPQ+FWNAGCQMV+LN+QT DLAMQ+N G +E
Sbjct: 607 HAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFE 666
Query: 642 YNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDM 701
YNG GY LKP+FMRRPD+ FDPF+E VDG++A T SV++ISGQFLSDKK+GTYVEVDM
Sbjct: 667 YNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDM 726
Query: 702 FGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRI 761
+GLP DT RK F+T+ N +NPV+ EE VF+KV+LP LA LRIAVY++ K IG RI
Sbjct: 727 YGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRI 786
Query: 762 LPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLME 821
LP+ ++ GY +I LRNE N+PL+LP +F I +K YVPD + D+++ALS+P +++++ E
Sbjct: 787 LPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITE 846
Query: 822 QRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHS 881
+RA Q+ A+ +E +D + PS+ + A +TP+ S+ +
Sbjct: 847 KRADQMRAMGIE-------TSDIADVPSDTSKNDKKGKANTA---KANVTPQSSSELRPT 896
Query: 882 QPAPGSVKAPAKTE-DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKK 940
A + AK +LI V IE+LKQ K+++K KK KE+ L K+H K+
Sbjct: 897 TTAALASGVEAKKGIELIPQV-------RIEDLKQMKAYLKHLKKQQKELNSLKKKHAKE 949
Query: 941 TTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIE--------- 991
+ + K H T+ ++I Y + ++ EK +K KKK GS+ +E
Sbjct: 950 HSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKG-------GSNCLEMKKETEIKI 1002
Query: 992 QDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQN 1051
Q L + ++++ K+ +++N + + L++KL A E Q
Sbjct: 1003 QTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQT 1062
Query: 1052 NQLKKLKEICEKEKKELKKKMDKKRQEKITEAKS-KDKSQMEEEKTEMIRSYIQEVVQYI 1110
QLK + KE + + K+ + + I++ KS K+K++ E E+ S ++ ++
Sbjct: 1063 QQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEER 1122
Query: 1111 KRLEEAQSKRQEKL 1124
KRL QSK ++L
Sbjct: 1123 KRLAMKQSKEMDQL 1136
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 342 bits (878), Expect = 1e-93
Identities = 245/718 (34%), Positives = 373/718 (51%), Gaps = 67/718 (9%)
Query: 98 LEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYT 157
LEQ V +G S+L+L+A E A+ W + L L +M L++ +
Sbjct: 87 LEQGFTIVFHG----RRSNLDLMANSVEEAQIWMRGLQLLVD--LVTSMDHQERLDQWLS 140
Query: 158 KL--KLQVTPEGRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPE 210
+ +G++ + + RL D++ + +A +S++ ++ E+F
Sbjct: 141 DWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAAD--TSQSGTLEGEEFVQ- 197
Query: 211 VYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ 270
F L R E+ +F F A + LT+ + +DF+ +Q++ E
Sbjct: 198 ----FYKALTKRAEVQELFESFSADGQK-LTLLEFLDFLQEEQKERDCTS--------EL 244
Query: 271 VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSS 330
LI++YEP++S + +S+DGF+ YL ++ + +P L + +DM+QPL+HYFI SS
Sbjct: 245 ALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSS 304
Query: 331 HNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKE 390
HNTYL QL G SSVE Y + L GCRCVE+D W G + E PV+ HG T+T+ I FK+
Sbjct: 305 HNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGE--PVVYHGHTLTSRILFKD 362
Query: 391 VIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV 450
V+ +A+ AF+TS +P++LS E H S +QQ MA + I G+ LL L+
Sbjct: 363 VVATVAQYAFQTSDYPVILSLETHC-SWEQQQTMARHLTEILGEQLLSTTLDGV---LPT 418
Query: 451 PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTE 510
LPSP +L KILVK KK + + +++ + + S FE E + +
Sbjct: 419 QLPSPEELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFET------EPEPQ 472
Query: 511 SDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSF 570
+ + D KKS + + +S+LV Y++ V F SF SK+ +E+SSF
Sbjct: 473 EQNLQNKDKKKKS---------KPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSF 523
Query: 571 VETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMD 630
ETK + ++ EFV++N QLSR+YP G R DSSNY PQ WNAGCQMVA+N QT
Sbjct: 524 SETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAG 583
Query: 631 LAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLS- 689
L M I G + NG GY LKP+F+R F P E + A TL +++ISGQ L
Sbjct: 584 LEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQVISGQQLPK 641
Query: 690 -DKK-----VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLA 743
DK V V+V +FG+ +DT R+ +T + N NP W + + +V++P LA
Sbjct: 642 VDKTKEGSIVDPLVKVQIFGVRLDTARQ--ETNYVENNGFNPYWGQ--TLCFRVLVPELA 697
Query: 744 CLRIAVYEEGGK----FIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKD 797
LR V + K FIG LP ++ GY +I L ++ L ++FVYI +++
Sbjct: 698 MLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQE 755
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 332 bits (850), Expect = 2e-90
Identities = 238/775 (30%), Positives = 384/775 (49%), Gaps = 86/775 (11%)
Query: 43 LRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRM 102
L TD Q + + ++ E LD+S +K+ R G++ + ++ L + + E
Sbjct: 137 LDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQI-------CEDCA 189
Query: 103 ITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAY 156
++++G N L+LVA +VA W + + L + + + N + F+
Sbjct: 190 FSILHGE---NYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKT 246
Query: 157 TKLKLQVTPEGRIPLKN----IYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVY 212
V G I L++ + + + K + L+ + S+ + T E +
Sbjct: 247 VFEAADVDGNG-IMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTR--VTEEEF 303
Query: 213 RVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQ 272
LC RPE+ + + +K+K YL + +M F+ +Q + E + +
Sbjct: 304 CEAFCELCTRPEVYFLLVQI-SKNKEYLDANDLMLFLEAEQGVTHITEDICLDI------ 356
Query: 273 VLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHN 332
I +YE + +KG +++DGF +YL E + PE+ + +DM+QPLSHY+IN+SHN
Sbjct: 357 --IRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHN 414
Query: 333 TYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVI 392
TYL Q G + + Y + L GCR VELD G ++ EP++ + MTT +SF+ VI
Sbjct: 415 TYLIEDQFRGPADINGYIRALKMGCRSVELDVSDG--SDNEPILCNRNNMTTHVSFRSVI 472
Query: 393 EAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPL 452
E I + AF S +P++L NH P+Q+ MA+ + +FG+ L E PL S L
Sbjct: 473 EVINKFAFVASEYPLILCLGNHCSLPQQKV-MAQQMKKVFGNKLYTEA----PLPSESYL 527
Query: 453 PSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESD 512
PSP L I+VK KK PS P E + +D
Sbjct: 528 PSPEKLKRMIIVKGKKL-----------------------------PSDPDVLEGEV-TD 557
Query: 513 DDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVE 572
+D++ + ++ S+D + E+S+LV+ + V++ FE+S K +EM SF E
Sbjct: 558 EDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSE 617
Query: 573 TKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLA 632
T+ + P +FV YNK LSRIYP R+DSSN PQ FWN GCQ+VA+NFQT
Sbjct: 618 TEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPM 677
Query: 633 MQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKK 692
M ++ G + NG GY L+P MR +F T+GI+ G+ L +KIISGQ K
Sbjct: 678 MDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPK 737
Query: 693 --------VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFK-KVVLPTLA 743
+ YV +++ G+P D + +TKT Q N+ NP+++E F+ +V LP LA
Sbjct: 738 GACAKGDVIDPYVCIEIHGIPADCSEQ--RTKTVQQNSDNPIFDE---TFEFQVNLPELA 792
Query: 744 CLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEV 795
+R V ++ G +FIG +P + ++PGY ++ LR+ + +FV+I +
Sbjct: 793 MIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 847
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 332 bits (850), Expect = 2e-90
Identities = 238/775 (30%), Positives = 384/775 (49%), Gaps = 86/775 (11%)
Query: 43 LRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRM 102
L TD Q + + ++ E LD+S +K+ R G++ + ++ L + + E
Sbjct: 39 LDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQI-------CEDCA 91
Query: 103 ITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAY 156
++++G N L+LVA +VA W + + L + + + N + F+
Sbjct: 92 FSILHGE---NYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKT 148
Query: 157 TKLKLQVTPEGRIPLKN----IYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVY 212
V G I L++ + + + K + L+ + S+ + T E +
Sbjct: 149 VFEAADVDGNG-IMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTR--VTEEEF 205
Query: 213 RVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQ 272
LC RPE+ + + +K+K YL + +M F+ +Q + E + +
Sbjct: 206 CEAFCELCTRPEVYFLLVQI-SKNKEYLDANDLMLFLEAEQGVTHITEDICLDI------ 258
Query: 273 VLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHN 332
I +YE + +KG +++DGF +YL E + PE+ + +DM+QPLSHY+IN+SHN
Sbjct: 259 --IRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHN 316
Query: 333 TYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVI 392
TYL Q G + + Y + L GCR VELD G ++ EP++ + MTT +SF+ VI
Sbjct: 317 TYLIEDQFRGPADINGYIRALKMGCRSVELDVSDG--SDNEPILCNRNNMTTHVSFRSVI 374
Query: 393 EAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPL 452
E I + AF S +P++L NH P+Q+ MA+ + +FG+ L E PL S L
Sbjct: 375 EVINKFAFVASEYPLILCLGNHCSLPQQKV-MAQQMKKVFGNKLYTEA----PLPSESYL 429
Query: 453 PSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESD 512
PSP L I+VK KK PS P E + +D
Sbjct: 430 PSPEKLKRMIIVKGKKL-----------------------------PSDPDVLEGEV-TD 459
Query: 513 DDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVE 572
+D++ + ++ S+D + E+S+LV+ + V++ FE+S K +EM SF E
Sbjct: 460 EDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSE 519
Query: 573 TKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLA 632
T+ + P +FV YNK LSRIYP R+DSSN PQ FWN GCQ+VA+NFQT
Sbjct: 520 TEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPM 579
Query: 633 MQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKK 692
M ++ G + NG GY L+P MR +F T+GI+ G+ L +KIISGQ K
Sbjct: 580 MDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPK 639
Query: 693 --------VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFK-KVVLPTLA 743
+ YV +++ G+P D + +TKT Q N+ NP+++E F+ +V LP LA
Sbjct: 640 GACAKGDVIDPYVCIEIHGIPADCSEQ--RTKTVQQNSDNPIFDE---TFEFQVNLPELA 694
Query: 744 CLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEV 795
+R V ++ G +FIG +P + ++PGY ++ LR+ + +FV+I +
Sbjct: 695 MIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 749
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 328 bits (840), Expect = 2e-89
Identities = 223/617 (36%), Positives = 316/617 (51%), Gaps = 67/617 (10%)
Query: 197 SRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDP 256
S+ DS+ E+ F L R EID F+E A S L+VDQ++ F+ +QR+
Sbjct: 191 SQTDSLEDEEI-----EAFYKMLTQRVEIDRTFAE-AAGSGETLSVDQLVTFLQHQQRE- 243
Query: 257 RLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNE 316
E P L LIE+YEP+ + + Q++ DGF+ YL + S + +
Sbjct: 244 ---EAAGPALALS----LIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQ 296
Query: 317 DMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVI 376
DM QPLSHY ++SSHNTYL QLAG SS E Y + L GCRC+ELDCW G +EP+I
Sbjct: 297 DMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDG--PNQEPII 354
Query: 377 THGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDAL 436
HG+T T++I F +V+ AI + AFK SP+P++LS ENH + +QQ MA + I G L
Sbjct: 355 YHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHC-TLEQQRVMARHLHAILGPML 413
Query: 437 LMEPLEKYPLESGV--PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSS 494
L PL+ GV LPSP L KIL+K KK
Sbjct: 414 LNRPLD------GVTNSLPSPEQLKGKILLKGKK------------------------LG 443
Query: 495 SMFEPSSPGAGEADTESDDDDD---DDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVK 551
+ P G EA SD+D+ +D+ +S + + +E+S++V Y + V
Sbjct: 444 GLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVH 503
Query: 552 FESFEISKKRNKSF-EMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYM 610
F F ++F EM+SF E + L L +S FV +N LSRIYP G R DSSNY
Sbjct: 504 FGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYS 563
Query: 611 PQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIV 670
P WN GCQ+VALNFQT M + G ++ NG GY LKP F+R P+ F+P
Sbjct: 564 PVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQG 623
Query: 671 DGIVANTLSVKIISGQFL------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVN 724
L++++ISGQ L + V V V++ G+ D + +T N N
Sbjct: 624 PWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASR--QTAVITNNGFN 681
Query: 725 PVWEEEPIVFKKVVLPTLACLRIAV--YEEGGK--FIGHRILPVQAIRPGYHYICLRNER 780
P W+ E F +VV+P LA +R V Y+ K FIG +P+ +++ GY ++ L ++
Sbjct: 682 PWWDTE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKN 739
Query: 781 NQPLTLPAVFVYIEVKD 797
+FV I ++D
Sbjct: 740 GDQHPSATLFVKISLQD 756
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 328 bits (840), Expect = 2e-89
Identities = 223/617 (36%), Positives = 316/617 (51%), Gaps = 67/617 (10%)
Query: 197 SRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDP 256
S+ DS+ E+ F L R EID F+E A S L+VDQ++ F+ +QR+
Sbjct: 212 SQTDSLEDEEI-----EAFYKMLTQRVEIDRTFAE-AAGSGETLSVDQLVTFLQHQQRE- 264
Query: 257 RLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNE 316
E P L LIE+YEP+ + + Q++ DGF+ YL + S + +
Sbjct: 265 ---EAAGPALALS----LIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQ 317
Query: 317 DMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVI 376
DM QPLSHY ++SSHNTYL QLAG SS E Y + L GCRC+ELDCW G +EP+I
Sbjct: 318 DMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDG--PNQEPII 375
Query: 377 THGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDAL 436
HG+T T++I F +V+ AI + AFK SP+P++LS ENH + +QQ MA + I G L
Sbjct: 376 YHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHC-TLEQQRVMARHLHAILGPML 434
Query: 437 LMEPLEKYPLESGV--PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSS 494
L PL+ GV LPSP L KIL+K KK
Sbjct: 435 LNRPLD------GVTNSLPSPEQLKGKILLKGKK------------------------LG 464
Query: 495 SMFEPSSPGAGEADTESDDDDD---DDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVK 551
+ P G EA SD+D+ +D+ +S + + +E+S++V Y + V
Sbjct: 465 GLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVH 524
Query: 552 FESFEISKKRNKSF-EMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYM 610
F F ++F EM+SF E + L L +S FV +N LSRIYP G R DSSNY
Sbjct: 525 FGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYS 584
Query: 611 PQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIV 670
P WN GCQ+VALNFQT M + G ++ NG GY LKP F+R P+ F+P
Sbjct: 585 PVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQG 644
Query: 671 DGIVANTLSVKIISGQFL------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVN 724
L++++ISGQ L + V V V++ G+ D + +T N N
Sbjct: 645 PWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASR--QTAVITNNGFN 702
Query: 725 PVWEEEPIVFKKVVLPTLACLRIAV--YEEGGK--FIGHRILPVQAIRPGYHYICLRNER 780
P W+ E F +VV+P LA +R V Y+ K FIG +P+ +++ GY ++ L ++
Sbjct: 703 PWWDTE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKN 760
Query: 781 NQPLTLPAVFVYIEVKD 797
+FV I ++D
Sbjct: 761 GDQHPSATLFVKISLQD 777
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 326 bits (835), Expect = 9e-89
Identities = 247/802 (30%), Positives = 392/802 (48%), Gaps = 88/802 (10%)
Query: 20 DSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHA 78
+S+ +G++ K +S I +L D Q + + ++ E +D+ +K+ R G++
Sbjct: 141 NSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNT 200
Query: 79 KAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLA 138
+ + + + E +V+YG N L+LVA +VA W + L
Sbjct: 201 DIFRSNGISDQIS-------EDCAFSVIYGE---NYESLDLVANSADVANIWVTGLRYLI 250
Query: 139 T------NLL--AQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIY---RLFSADRKRVET 187
+ ++L +Q+ R +++ + ++++ V G I L N R + K +
Sbjct: 251 SYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNAVQCIRNLNPGLKTSKI 308
Query: 188 ALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMD 247
L+ L S++ + + T E + + LC RPEI + +F + +K +L +M
Sbjct: 309 ELKFKELHKSKDKA--GTEVTKEEFIEVFHELCTRPEIYFLLVQFSS-NKEFLDTKDLMM 365
Query: 248 FINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVV 307
F+ +Q +NE E +I KYEP+ KG +S+DGF YL + +
Sbjct: 366 FLEAEQGVAHINE--------EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF 417
Query: 308 SPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKG 367
PE + +DM QPLSHYFINSSHNTYL Q G S + Y + L GCR VELD W G
Sbjct: 418 DPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDG 477
Query: 368 RTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEY 427
+ EPVI G TMT++I F+ VI+ I + AF S +P++L ENH S KQQ M ++
Sbjct: 478 --PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHC-SIKQQKVMVQH 534
Query: 428 CRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQAS 487
+ + GD L P LPSP L KIL+K KK S S SG +
Sbjct: 535 MKKLLGDKLYTTS----PNVEESYLPSPDVLKGKILIKAKKLS---SNCSGVE------- 580
Query: 488 NTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDE--GTAGSEAMATEEMSNLVN 545
G+ E + + K +M++ +E+S LV+
Sbjct: 581 -----------------GDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVS 623
Query: 546 YIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVD 605
+ V+F+ F++S + K +E+ SF E + ++P +FV YNK L+R++P R+D
Sbjct: 624 ICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRID 683
Query: 606 SSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPF 665
SSN PQ FW GCQ+VA+NFQT L M +N+G + NG GY L+P MR F
Sbjct: 684 SSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSAN 743
Query: 666 TEGIVDGIVANTLSVKIISGQFLSDKK--------VGTYVEVDMFGLPVDTRRKAFKTKT 717
T+ V G+ L +KIISGQ K V YV V++ G+P D + +TKT
Sbjct: 744 TKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKT 801
Query: 718 SQGNAVNPVWEEEPIVFK-KVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHY 773
N P+++E F+ ++ LP LA +R V ++ G +FIG +P + ++ GY +
Sbjct: 802 VHQNGDAPIFDES---FEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858
Query: 774 ICLRNERNQPLTLPAVFVYIEV 795
+ L++ + L ++FV++ +
Sbjct: 859 VPLQSLTGEVLAHASLFVHVAI 880
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 326 bits (835), Expect = 9e-89
Identities = 247/802 (30%), Positives = 392/802 (48%), Gaps = 88/802 (10%)
Query: 20 DSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHA 78
+S+ +G++ K +S I +L D Q + + ++ E +D+ +K+ R G++
Sbjct: 15 NSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNT 74
Query: 79 KAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLA 138
+ + + + E +V+YG N L+LVA +VA W + L
Sbjct: 75 DIFRSNGISDQIS-------EDCAFSVIYGE---NYESLDLVANSADVANIWVTGLRYLI 124
Query: 139 T------NLL--AQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIY---RLFSADRKRVET 187
+ ++L +Q+ R +++ + ++++ V G I L N R + K +
Sbjct: 125 SYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNAVQCIRNLNPGLKTSKI 182
Query: 188 ALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMD 247
L+ L S++ + + T E + + LC RPEI + +F + +K +L +M
Sbjct: 183 ELKFKELHKSKDKA--GTEVTKEEFIEVFHELCTRPEIYFLLVQFSS-NKEFLDTKDLMM 239
Query: 248 FINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVV 307
F+ +Q +NE E +I KYEP+ KG +S+DGF YL + +
Sbjct: 240 FLEAEQGVAHINE--------EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF 291
Query: 308 SPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKG 367
PE + +DM QPLSHYFINSSHNTYL Q G S + Y + L GCR VELD W G
Sbjct: 292 DPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDG 351
Query: 368 RTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEY 427
+ EPVI G TMT++I F+ VI+ I + AF S +P++L ENH S KQQ M ++
Sbjct: 352 --PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHC-SIKQQKVMVQH 408
Query: 428 CRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQAS 487
+ + GD L P LPSP L KIL+K KK S S SG +
Sbjct: 409 MKKLLGDKLYTTS----PNVEESYLPSPDVLKGKILIKAKKLS---SNCSGVE------- 454
Query: 488 NTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDE--GTAGSEAMATEEMSNLVN 545
G+ E + + K +M++ +E+S LV+
Sbjct: 455 -----------------GDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVS 497
Query: 546 YIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVD 605
+ V+F+ F++S + K +E+ SF E + ++P +FV YNK L+R++P R+D
Sbjct: 498 ICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRID 557
Query: 606 SSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPF 665
SSN PQ FW GCQ+VA+NFQT L M +N+G + NG GY L+P MR F
Sbjct: 558 SSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSAN 617
Query: 666 TEGIVDGIVANTLSVKIISGQFLSDKK--------VGTYVEVDMFGLPVDTRRKAFKTKT 717
T+ V G+ L +KIISGQ K V YV V++ G+P D + +TKT
Sbjct: 618 TKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKT 675
Query: 718 SQGNAVNPVWEEEPIVFK-KVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHY 773
N P+++E F+ ++ LP LA +R V ++ G +FIG +P + ++ GY +
Sbjct: 676 VHQNGDAPIFDES---FEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 732
Query: 774 ICLRNERNQPLTLPAVFVYIEV 795
+ L++ + L ++FV++ +
Sbjct: 733 VPLQSLTGEVLAHASLFVHVAI 754
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 318 bits (816), Expect = 2e-86
Identities = 240/787 (30%), Positives = 372/787 (47%), Gaps = 142/787 (18%)
Query: 117 LNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPEGRIP 170
L+LV+ EVA+ W + L +L + +RD +L++ + + +G +
Sbjct: 133 LDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEA--DKNGDGSLS 190
Query: 171 LKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEI 225
+ + +L + R+RV+ + ++ E+F F + R ++
Sbjct: 191 IGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQG-TLGFEEFC-----AFYKMMSTRRDL 244
Query: 226 DNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLA 285
+ + + K +L + F+ ++Q+ + E Q +IE++EP
Sbjct: 245 YLLMLTY-SNHKDHLDAASLQRFLQVEQK--------MAGVTLESCQDIIEQFEPCPENK 295
Query: 286 RKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSS 345
KG + +DGF Y + +PE +++DM+QPLSHYFI SSHNTYL QL S
Sbjct: 296 SKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSR 355
Query: 346 VEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPF 405
V+MY VL +GCRCVE+DCW G + EP++ HG+T+T++I FK+VIE I + AF + +
Sbjct: 356 VDMYAWVLQAGCRCVEVDCWDG--PDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEY 413
Query: 406 PILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVK 465
P++LS ENH S QQ KMA+Y I GD L L E LPSP L KILVK
Sbjct: 414 PVILSIENHC-SVIQQKKMAQYLTDILGDKL---DLSSVSSEDATTLPSPQMLKGKILVK 469
Query: 466 NKK-----------------------------------KSHKSSEGSGKKKLSE------ 484
KK + K E + K+KL
Sbjct: 470 GKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESK 529
Query: 485 --QASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDC---------------------- 520
+ + S S PS ++ E D + +D
Sbjct: 530 IRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSK 589
Query: 521 --KKSSMDEGTAGSEAMATEE---------------MSNLVNYIQPVKFESFEISKKRNK 563
K +S++EG G ++ + +S+LV Y + V + +I +
Sbjct: 590 LKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVA--THDIEMEAAS 647
Query: 564 SFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVA 623
S+++SSF ETK + L + P +++ +N+ QLSRIYP RVDSSNY PQ FWNAGCQMVA
Sbjct: 648 SWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVA 707
Query: 624 LNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKII 683
LN+Q+ +Q+N + NG GY LKP M + F+P +E + G + L ++II
Sbjct: 708 LNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQ--GVFNPNSEDPLPGQLKKQLVLRII 765
Query: 684 SGQFLSDKK----------VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIV 733
SGQ L + + +VEV++ GLPVD R+ +T+ N NP W EE +V
Sbjct: 766 SGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSRE--QTRVVDDNGFNPTW-EETLV 822
Query: 734 FKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVF 790
F V +P +A +R V++ G FIG R L ++ PGY ++ L + + ++F
Sbjct: 823 F-MVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYL-----EGMEEASIF 876
Query: 791 VYIEVKD 797
V++ V D
Sbjct: 877 VHVAVSD 883
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 312 bits (800), Expect = 1e-84
Identities = 212/609 (34%), Positives = 328/609 (53%), Gaps = 65/609 (10%)
Query: 199 NDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRL 258
ND + Q T E +R + R EI IF+ + ++++ L + F+ +Q +
Sbjct: 47 NDRLKQGRITIEEFRAIYRIITHREEIIEIFNTY-SENRKILLASNLAQFLTQEQYAAEM 105
Query: 259 NEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDM 318
++ + +I+KYEP + + Q+S++GF RY+ E + E + +DM
Sbjct: 106 SKAI--------AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDM 157
Query: 319 SQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITH 378
+ PL+ YFI+SSHNTYL + QL G S + Y L+ GCRC+E+DCW G A+ EPV+ H
Sbjct: 158 THPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDG--AQNEPVVYH 215
Query: 379 GFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLM 438
G+T+T+++ FK VI+AI + AF TS +P++LS ENH S QQ MA+ + FG++LL
Sbjct: 216 GYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHC-STAQQEVMADNLQATFGESLLS 274
Query: 439 EPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE 498
+ L+ +P LPSP L +KILVKNKK G+ K+ + S
Sbjct: 275 DMLDDFP----DTLPSPEALKFKILVKNKK------IGTLKETHERKGS----------- 313
Query: 499 PSSPGAGEADTESDDDDDDDDCKK---SSMDEGTAGSEAMATEEMSNLVNYIQPVKFESF 555
D D+ D + KK + + + +S+LV Y + KF+SF
Sbjct: 314 ---------DKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSF 364
Query: 556 EISKKRNKSFEMSSFVETKGLEQLTKSPV-EFVEYNKMQLSRIYPKGTRVDSSNYMPQLF 614
+ S+ + E +S ET+ +L+K V EF+ + + ++RIYPK TR DSSN+ PQ F
Sbjct: 365 QHSRLYQQFNENNSIGETQA-RKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEF 423
Query: 615 WNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIV 674
WN GCQMVALNFQT L M + G + NG SGY LKP F+R +F+P I +G+
Sbjct: 424 WNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNP--SNIKEGMP 481
Query: 675 ANTLSVKIISGQFL-----SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEE 729
TL++++ISG L S K + V +++FG+P D ++ +T+ + NA +P W E
Sbjct: 482 I-TLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQ--QTRVIKKNAFSPRWNE 538
Query: 730 EPIVFKKVV-LPTLACLRIAVYEE----GGKFIGHRILPVQAIRPGYHYICLRNERNQPL 784
F ++ +P LA +R V + G +F+G LP+ + GY I L + + L
Sbjct: 539 ---TFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESL 595
Query: 785 TLPAVFVYI 793
++FVY+
Sbjct: 596 EPASLFVYV 604
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 307 bits (787), Expect = 3e-83
Identities = 210/698 (30%), Positives = 348/698 (49%), Gaps = 76/698 (10%)
Query: 116 HLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSR------DAFLEKAYTKLKLQVTPEGRI 169
+L+L A E A+ W + L L A + ++L +A + +++ +
Sbjct: 149 NLDLAAPTAEEAQRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFK--- 205
Query: 170 PLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIF 229
+K++ R+ + D + L S ND + + FL L RPE++ IF
Sbjct: 206 EIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEGAEIEE-----FLRRLLKRPELEEIF 260
Query: 230 SEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQ 289
++ + + L+ ++++F+ + + + Q LI+ YE N + +
Sbjct: 261 HQYSGEDR-VLSAPELLEFLEDQGEEGAT---------LARAQQLIQTYELNETAKQHEL 310
Query: 290 ISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMY 349
+++DGFM YL E + + +DM+QPL+HYFI+SSHNTYLT Q+ G SS E Y
Sbjct: 311 MTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAY 370
Query: 350 RQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILL 409
+ GCRCVELDCW+G E PVI HG T+T++I F++V++A+ + AF SP+P++L
Sbjct: 371 VRAFAQGCRCVELDCWEGPGGE--PVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVIL 428
Query: 410 SFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKK 469
S ENH +QQA MA + I GD L+ + L+ E LPSP L ++LVK KK
Sbjct: 429 SLENHCGL-EQQAAMARHLCTILGDMLVTQALDSPNPEE---LPSPEQLKGRVLVKGKKL 484
Query: 470 SHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGT 529
SE + LS++ + E +DD+++++ +++
Sbjct: 485 PAARSEDG--RALSDR----------------------EEEEEDDEEEEEEVEAAAQRRL 520
Query: 530 AGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEY 589
A + E+S L Y + + + + ++SS E K + + ++ FV +
Sbjct: 521 A---KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRH 577
Query: 590 NKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYR 649
N QL+R+YP G R++S+NY PQ WN+GCQ+VALNFQT M +N G + NG+ GY
Sbjct: 578 NARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYV 637
Query: 650 LKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKK-------VGTYVEVDMF 702
LKP +R+PD FDP G TLS+++++ Q L V V +++
Sbjct: 638 LKPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIH 693
Query: 703 GLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYE----EGGKFIG 758
G+P D R+ +T N NP W + + ++ P LA +R V + F+G
Sbjct: 694 GVPADCARQ--ETDYVLNNGFNPRWGQ--TLQFQLRAPELALVRFVVEDYDATSPNDFVG 749
Query: 759 HRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVK 796
LP+ +++ GY +I L ++ L+ +F+ I ++
Sbjct: 750 QFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRIQ 787
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 187 bits (476), Expect = 4e-47
Identities = 122/337 (36%), Positives = 190/337 (56%), Gaps = 21/337 (6%)
Query: 269 EQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLN-EDMSQPLSHYFI 327
+++ +I+K+EP+ S+ +G +S +GF R+L +EN ++ N +++ PLS+Y+I
Sbjct: 1344 DEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLSYYYI 1403
Query: 328 NSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEIS 387
SSHNTYLT QL G SSVE+Y QVLL GCR VELDCW G + P+I HG T+TT+I
Sbjct: 1404 ESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDG--DDGMPIIYHGHTLTTKIP 1461
Query: 388 FKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLE 447
FKEV+EAI AF S PI++S ENH P QQ KMAE + +FG+ L+ + L +
Sbjct: 1462 FKEVVEAIDRSAFINSDLPIIISIENHCSLP-QQRKMAEIFKTVFGEKLVTKFLFETDFS 1520
Query: 448 SGVPLPSPMDLMYKILVKNKK-KSHKSSEGSGKKKLSEQAS---NTYSDSSSMFEPSSPG 503
LPSP L K+L+KNKK K+H++ K+K + AS Y+ ++ P++
Sbjct: 1521 DDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQAYNGGNANPRPAN-- 1578
Query: 504 AGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNK 563
+ E +D++D+ D S+ S+ E+ + ++FE E KR K
Sbjct: 1579 ----NEEEEDEEDEYDYDYESL------SDDNILEDRPENKSCNDKLQFEYNEEIPKRIK 1628
Query: 564 SFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK 600
+ S+ + K + + +++ NK + +I P+
Sbjct: 1629 KADNSACNKGK-VYDMELGEEFYLDQNKKESRQIAPE 1664
Score = 128 bits (322), Expect = 3e-29
Identities = 81/236 (34%), Positives = 126/236 (53%), Gaps = 12/236 (5%)
Query: 563 KSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMV 622
K + +SS E + + ++ QL R YP TR+DSSN P +FW G Q+V
Sbjct: 1753 KCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLV 1812
Query: 623 ALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPD----KHFDPFTEGIVDGIVANTL 678
ALN+QT DL + +N M+E NG GY LKP + + + F P E +D +
Sbjct: 1813 ALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPL-ERDLDSMDPAVY 1871
Query: 679 SVKIISGQFL--SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKK 736
S+ I+SGQ + S+ +EVD+ G+P+D+ F+TK N +NP+W E+ +
Sbjct: 1872 SLTIVSGQNVCPSNSMGSPCIEVDVLGMPLDSCH--FRTKPIHRNTLNPMWNEQFLF--H 1927
Query: 737 VVLPTLACLRIAVYEEGGKFI-GHRILPVQAIRPGYHYICLRNERNQPLTLPAVFV 791
V L LR AV E + RI+P++A++ GY ++ LRN N+ L + ++F+
Sbjct: 1928 VHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFI 1983
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 174 bits (441), Expect = 5e-43
Identities = 119/411 (28%), Positives = 212/411 (51%), Gaps = 35/411 (8%)
Query: 113 NISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPE 166
++ L+L+ E A+ W + L +L + + D ++++ + + +
Sbjct: 102 HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEA--DKNGD 159
Query: 167 GRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP 221
G + ++ I++L + R++V + + Q T E + VF +
Sbjct: 160 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDEN------QGTLTFEEFCVFYKMMSL 213
Query: 222 RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN 281
R ++ + + K K +LTV+++ F+ ++Q+ +N + + +I+K+E +
Sbjct: 214 RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT-----TDYCLDIIKKFEVS 264
Query: 282 NSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA 341
K + ++GF ++ + +P ++ +DM QPL +Y+I SSHNTYLT QL
Sbjct: 265 EENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLL 324
Query: 342 GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK 401
S V+MY +VL GCRCVE+DCW G + EPV+ HG+T+T++I F++V+E I + AF
Sbjct: 325 SQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETINKHAFV 382
Query: 402 TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461
+ FP++LS ENH S +QQ K+A+Y + IFGD L + ++ + LPSP L K
Sbjct: 383 KNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQ---LPSPQSLKGK 438
Query: 462 ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE-PSSPGAGEADTES 511
ILVK KK + + + + ++S++ S + F+ S G E ES
Sbjct: 439 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVES 489
Score = 145 bits (366), Expect = 2e-34
Identities = 99/309 (32%), Positives = 161/309 (52%), Gaps = 34/309 (11%)
Query: 509 TESDDDDDDDDCKKSSMDEG-------TAGSEAMATEEMSNLVNYIQPVKFESFEISKKR 561
++S DD++D ++S+ EG E+S+LV Y V +
Sbjct: 563 SKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDD--- 619
Query: 562 NKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQM 621
+ + SF ET+ + + + +F+ YN+ QL+RIYP R+DSSN+ P +WNAGCQ+
Sbjct: 620 GTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQL 679
Query: 622 VALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVK 681
VALN+Q+ MQ+N ++ NG GY LKP+ M + F+PF+ + L +K
Sbjct: 680 VALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--FNPFSGDPLPANPKKQLILK 737
Query: 682 IISGQFL----------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEP 731
+ISGQ L + + +VEV++ GLPVD + +T+ N NPVW EE
Sbjct: 738 VISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD--QTRVVDDNGFNPVW-EET 794
Query: 732 IVFKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788
+ F V +P +A +R V++ G F+G R + ++ PGY ++ L + LT +
Sbjct: 795 LTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEAS 848
Query: 789 VFVYIEVKD 797
+FV+I + +
Sbjct: 849 IFVHITINE 857
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 174 bits (441), Expect = 5e-43
Identities = 119/411 (28%), Positives = 212/411 (51%), Gaps = 35/411 (8%)
Query: 113 NISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPE 166
++ L+L+ E A+ W + L +L + + D ++++ + + +
Sbjct: 102 HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEA--DKNGD 159
Query: 167 GRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP 221
G + ++ I++L + R++V + + Q T E + VF +
Sbjct: 160 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDEN------QGTLTFEEFCVFYKMMSL 213
Query: 222 RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN 281
R ++ + + K K +LTV+++ F+ ++Q+ +N + + +I+K+E +
Sbjct: 214 RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT-----TDYCLDIIKKFEVS 264
Query: 282 NSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA 341
K + ++GF ++ + +P ++ +DM QPL +Y+I SSHNTYLT QL
Sbjct: 265 EENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLL 324
Query: 342 GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK 401
S V+MY +VL GCRCVE+DCW G + EPV+ HG+T+T++I F++V+E I + AF
Sbjct: 325 SQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETINKHAFV 382
Query: 402 TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461
+ FP++LS ENH S +QQ K+A+Y + IFGD L + ++ + LPSP L K
Sbjct: 383 KNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQ---LPSPQSLKGK 438
Query: 462 ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE-PSSPGAGEADTES 511
ILVK KK + + + + ++S++ S + F+ S G E ES
Sbjct: 439 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVES 489
Score = 145 bits (366), Expect = 2e-34
Identities = 99/309 (32%), Positives = 161/309 (52%), Gaps = 34/309 (11%)
Query: 509 TESDDDDDDDDCKKSSMDEG-------TAGSEAMATEEMSNLVNYIQPVKFESFEISKKR 561
++S DD++D ++S+ EG E+S+LV Y V +
Sbjct: 563 SKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDD--- 619
Query: 562 NKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQM 621
+ + SF ET+ + + + +F+ YN+ QL+RIYP R+DSSN+ P +WNAGCQ+
Sbjct: 620 GTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQL 679
Query: 622 VALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVK 681
VALN+Q+ MQ+N ++ NG GY LKP+ M + F+PF+ + L +K
Sbjct: 680 VALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--FNPFSGDPLPANPKKQLILK 737
Query: 682 IISGQFL----------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEP 731
+ISGQ L + + +VEV++ GLPVD + +T+ N NPVW EE
Sbjct: 738 VISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD--QTRVVDDNGFNPVW-EET 794
Query: 732 IVFKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788
+ F V +P +A +R V++ G F+G R + ++ PGY ++ L + LT +
Sbjct: 795 LTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEAS 848
Query: 789 VFVYIEVKD 797
+FV+I + +
Sbjct: 849 IFVHITINE 857
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 174 bits (441), Expect = 5e-43
Identities = 119/411 (28%), Positives = 212/411 (51%), Gaps = 35/411 (8%)
Query: 113 NISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPE 166
++ L+L+ E A+ W + L +L + + D ++++ + + +
Sbjct: 84 HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEA--DKNGD 141
Query: 167 GRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP 221
G + ++ I++L + R++V + + Q T E + VF +
Sbjct: 142 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDEN------QGTLTFEEFCVFYKMMSL 195
Query: 222 RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN 281
R ++ + + K K +LTV+++ F+ ++Q+ +N + + +I+K+E +
Sbjct: 196 RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT-----TDYCLDIIKKFEVS 246
Query: 282 NSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA 341
K + ++GF ++ + +P ++ +DM QPL +Y+I SSHNTYLT QL
Sbjct: 247 EENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLL 306
Query: 342 GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK 401
S V+MY +VL GCRCVE+DCW G + EPV+ HG+T+T++I F++V+E I + AF
Sbjct: 307 SQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETINKHAFV 364
Query: 402 TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461
+ FP++LS ENH S +QQ K+A+Y + IFGD L + ++ + LPSP L K
Sbjct: 365 KNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQ---LPSPQSLKGK 420
Query: 462 ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE-PSSPGAGEADTES 511
ILVK KK + + + + ++S++ S + F+ S G E ES
Sbjct: 421 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVES 471
Score = 145 bits (366), Expect = 2e-34
Identities = 99/309 (32%), Positives = 161/309 (52%), Gaps = 34/309 (11%)
Query: 509 TESDDDDDDDDCKKSSMDEG-------TAGSEAMATEEMSNLVNYIQPVKFESFEISKKR 561
++S DD++D ++S+ EG E+S+LV Y V +
Sbjct: 545 SKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDD--- 601
Query: 562 NKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQM 621
+ + SF ET+ + + + +F+ YN+ QL+RIYP R+DSSN+ P +WNAGCQ+
Sbjct: 602 GTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQL 661
Query: 622 VALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVK 681
VALN+Q+ MQ+N ++ NG GY LKP+ M + F+PF+ + L +K
Sbjct: 662 VALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--FNPFSGDPLPANPKKQLILK 719
Query: 682 IISGQFL----------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEP 731
+ISGQ L + + +VEV++ GLPVD + +T+ N NPVW EE
Sbjct: 720 VISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD--QTRVVDDNGFNPVW-EET 776
Query: 732 IVFKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788
+ F V +P +A +R V++ G F+G R + ++ PGY ++ L + LT +
Sbjct: 777 LTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEAS 830
Query: 789 VFVYIEVKD 797
+FV+I + +
Sbjct: 831 IFVHITINE 839
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 164 bits (416), Expect = 4e-40
Identities = 97/265 (36%), Positives = 152/265 (57%), Gaps = 13/265 (4%)
Query: 539 EMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSP-VEFVEYNKMQLSRI 597
E+S LV Y +PV F+ +I +R +MSSF ETK + + K+ +F++YN++QLSRI
Sbjct: 952 ELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRI 1011
Query: 598 YPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRR 657
YPKG R+DSSNY P W G Q+VALNFQT D MQ+N ++ GY L+P MR
Sbjct: 1012 YPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR- 1070
Query: 658 PDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVG---TYVEVDMFGLPVDTRRKAFK 714
D+ FDPF + + G+ +S++++ + L G +VE+++ G D+ ++ K
Sbjct: 1071 -DEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ--K 1127
Query: 715 TKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEE----GGKFIGHRILPVQAIRPG 770
T+ N +NPVW +P F ++ P A LR VYEE F+ PV+ ++ G
Sbjct: 1128 TEFVVDNGLNPVWPAKPFHF-QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTG 1186
Query: 771 YHYICLRNERNQPLTLPAVFVYIEV 795
Y + L+N ++ L L ++ + I++
Sbjct: 1187 YRAVPLKNNYSEDLELASLLIKIDI 1211
Score = 150 bits (380), Expect = 5e-36
Identities = 88/205 (42%), Positives = 125/205 (60%), Gaps = 12/205 (5%)
Query: 292 VDGFMRYLSGEENGVVSPEKLDLNED-MSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYR 350
+D F+ +L +EN V + + + D M+ PLSHY+I+SSHNTYLT Q + SS+E Y
Sbjct: 295 LDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYA 354
Query: 351 QVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLS 410
+ L GCRC+ELDCW G + PVI HG T+TT+I F +V+ I E AF S +P++LS
Sbjct: 355 RCLRMGCRCIELDCWDG--PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS 412
Query: 411 FENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKS 470
E+H S QQ MA+Y + + GD LL +P+E S LPSP L KIL+K+K
Sbjct: 413 IEDHC-SIAQQRNMAQYFKKVLGDTLLTKPVE----ISADGLPSPNQLKRKILIKHK--- 464
Query: 471 HKSSEGSGKKKLSEQASNTYSDSSS 495
K +EGS +++ + +D S+
Sbjct: 465 -KLAEGSAYEEVPTSMMYSENDISN 488
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 164 bits (416), Expect = 4e-40
Identities = 97/265 (36%), Positives = 152/265 (57%), Gaps = 13/265 (4%)
Query: 539 EMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSP-VEFVEYNKMQLSRI 597
E+S LV Y +PV F+ +I +R +MSSF ETK + + K+ +F++YN++QLSRI
Sbjct: 952 ELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRI 1011
Query: 598 YPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRR 657
YPKG R+DSSNY P W G Q+VALNFQT D MQ+N ++ GY L+P MR
Sbjct: 1012 YPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR- 1070
Query: 658 PDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVG---TYVEVDMFGLPVDTRRKAFK 714
D+ FDPF + + G+ +S++++ + L G +VE+++ G D+ ++ K
Sbjct: 1071 -DEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ--K 1127
Query: 715 TKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEE----GGKFIGHRILPVQAIRPG 770
T+ N +NPVW +P F ++ P A LR VYEE F+ PV+ ++ G
Sbjct: 1128 TEFVVDNGLNPVWPAKPFHF-QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTG 1186
Query: 771 YHYICLRNERNQPLTLPAVFVYIEV 795
Y + L+N ++ L L ++ + I++
Sbjct: 1187 YRAVPLKNNYSEDLELASLLIKIDI 1211
Score = 150 bits (380), Expect = 5e-36
Identities = 88/205 (42%), Positives = 125/205 (60%), Gaps = 12/205 (5%)
Query: 292 VDGFMRYLSGEENGVVSPEKLDLNED-MSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYR 350
+D F+ +L +EN V + + + D M+ PLSHY+I+SSHNTYLT Q + SS+E Y
Sbjct: 295 LDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYA 354
Query: 351 QVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLS 410
+ L GCRC+ELDCW G + PVI HG T+TT+I F +V+ I E AF S +P++LS
Sbjct: 355 RCLRMGCRCIELDCWDG--PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS 412
Query: 411 FENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKS 470
E+H S QQ MA+Y + + GD LL +P+E S LPSP L KIL+K+K
Sbjct: 413 IEDHC-SIAQQRNMAQYFKKVLGDTLLTKPVE----ISADGLPSPNQLKRKILIKHK--- 464
Query: 471 HKSSEGSGKKKLSEQASNTYSDSSS 495
K +EGS +++ + +D S+
Sbjct: 465 -KLAEGSAYEEVPTSMMYSENDISN 488
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 157 bits (398), Expect = 4e-38
Identities = 89/179 (49%), Positives = 115/179 (64%), Gaps = 10/179 (5%)
Query: 292 VDGFMRYLSGEENGVVSPEKLDL--NEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMY 349
VD F+ YL EN + EK D +DM+ PLSHY+I+SSHNTYLT QL SS E Y
Sbjct: 287 VDEFLTYLFSRENSIWD-EKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAY 345
Query: 350 RQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILL 409
+ L GCRC+ELDCW G + +PVI HG+T TT+I F +V++AI + AF TS FP++L
Sbjct: 346 IRCLRMGCRCIELDCWDG--PDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVIL 403
Query: 410 SFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKK 468
S E H S +QQ MA+ + +FGD LL +P E S LPSP L KI++K+KK
Sbjct: 404 SIEEHC-SVEQQRHMAKAFKEVFGDLLLTKPTE----ASADQLPSPSQLREKIIIKHKK 457
Score = 156 bits (394), Expect = 1e-37
Identities = 99/270 (36%), Positives = 153/270 (56%), Gaps = 23/270 (8%)
Query: 539 EMSNLVNYIQPVKFESFEISKKRNKSF-EMSSFVETKGLEQLTKSPVEFVEYNKMQLSRI 597
E+S+LV Y +P + N F E+ SFVETK + + PV+ ++YN+ L+R+
Sbjct: 929 ELSDLVVYCKPTSKTKDNLE---NPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRV 985
Query: 598 YPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRR 657
YPKG RVDSSNY P W G QMVALNFQT D MQ+N ++ NG++GY L+PE MR
Sbjct: 986 YPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR- 1044
Query: 658 PDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVG-----TYVEVDMFGLPVDTRRKA 712
+ +DP I+ TL+VK++ + L K+G +VEV++ G D +
Sbjct: 1045 -TEKYDPMPPESQRKILM-TLTVKVLGARHL--PKLGRSIACPFVEVEICGAEYDNNK-- 1098
Query: 713 FKTKTSQGNAVNPVW--EEEPIVFKKVVLPTLACLRIAVYEE----GGKFIGHRILPVQA 766
FKT N ++P+W +E + F ++ P LA LR VYEE F+ H P++A
Sbjct: 1099 FKTTVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKA 1157
Query: 767 IRPGYHYICLRNERNQPLTLPAVFVYIEVK 796
++ G+ + L+N ++ + L ++ V+ E++
Sbjct: 1158 VKSGFRSVPLKNGYSEDIELASLLVFCEMR 1187
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo sapiens]
Length = 955
Score = 68.2 bits (165), Expect = 5e-11
Identities = 71/333 (21%), Positives = 150/333 (45%), Gaps = 27/333 (8%)
Query: 818 NLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQ 877
++ E++A L + + +E+ +K+ E + E T E V +
Sbjct: 547 HIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTE--VQRLQAQQADAALE 604
Query: 878 ALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFV----KLQKKHYKEMKDL 933
Q S K A+ ++ ++ V ++ KQ K F+ +++++ +++ +L
Sbjct: 605 EFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVEL 664
Query: 934 VKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAK-KDSKKKSEPSSPDHGSSTIEQ 992
H ++ T L+++H + + + D+ R LEK + + + +++ + +
Sbjct: 665 KLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIA 724
Query: 993 DLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNN 1052
D+ A ++ ++LI++ +++QQL+ L + ++ REH
Sbjct: 725 DMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREH----------------EI 768
Query: 1053 QLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMI---RSYIQEVVQY 1109
+ KLK EK K ELKK + + + +A SK K Q+E+E T+ + I E+
Sbjct: 769 VVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLK-QIEKEYTQKLAKSSQIIAELQTT 827
Query: 1110 IKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKL 1142
I L+E S++Q + +++RQ+ DEK +L
Sbjct: 828 ISSLKEENSQQQLAAERRLQDVRQKFEDEKKQL 860
Score = 57.4 bits (137), Expect = 8e-08
Identities = 86/415 (20%), Positives = 175/415 (42%), Gaps = 64/415 (15%)
Query: 815 RYVNLMEQRAKQLAALTLEDEEEVKK---EADPGETP---SEAPSEARTTPAENGVNHTT 868
+Y + R+ L+ ED + + E ++P ++ EAR G+ +
Sbjct: 160 QYTGKLRVRSHSLSPTHREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPR 219
Query: 869 TLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQT---IEELKQQKSFVKLQKK 925
L KP +L + P K+ + +D S + E E + E K + +KLQ+K
Sbjct: 220 YLRQKPIPVSLMT-PKFSLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQK 278
Query: 926 HYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQN---------DYLRRRAALEKSAKKD--- 973
H +++ +++R + + +L + +K +E + L R + + K+D
Sbjct: 279 HDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIA 338
Query: 974 SKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQL----------LNLRQEQ 1023
KK S + ++ E+ L AEM Q+ DL+ + + + LN + +
Sbjct: 339 ELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESE 398
Query: 1024 YYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEA 1083
Y ++ IK L ++ + E +N+ L++ K I +EK EL++ E + E
Sbjct: 399 YMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLI--QEKAELERCYQITCSE-LQEV 455
Query: 1084 KSKDKSQMEEEKTEMIRSYIQ-------------------------EVVQYIKRLEEAQS 1118
K++ ++ + +EK ++ Y Q + I+ LE+
Sbjct: 456 KAR-RNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVC 514
Query: 1119 KRQEKLVEKHKEIRQQILDEKPKLQVE---LEQEYQDKFKRLPLEILEFVQEAMK 1170
+ +++L E + +QQ+ D++ K Q+E L+ Y+ K L E+ + ++ K
Sbjct: 515 QLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQK 569
Score = 50.4 bits (119), Expect = 1e-05
Identities = 67/310 (21%), Positives = 138/310 (44%), Gaps = 57/310 (18%)
Query: 889 KAPAKTEDLIQS--VLTEVEAQTIEELKQ-------------QKSFVKLQKKHYKEMKDL 933
K K + LI+ V+ E + I ELK+ +K + +E DL
Sbjct: 314 KLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDL 373
Query: 934 VKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQD 993
K+H + +L+++ + N+++++Y+ + + K+ + + + S+ Q
Sbjct: 374 QKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQK 433
Query: 994 LAALDAEMTQ-------KLIDLKDKQQ-------------QQLLNLRQEQYYSEKYQKRE 1033
L AE+ + +L ++K ++ +Q + L Q +Y ++ ++
Sbjct: 434 LIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQ 493
Query: 1034 HIKLLIQKLTDVAEECQNN--QLKKLKEICEKEKK------ELKKKMDKKRQEKITEAKS 1085
L K + + EE + N QLK+ + E ++K E K +M+K + I E K+
Sbjct: 494 EHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKA 553
Query: 1086 KD-KSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKL--VEKHKEIRQQILD---EK 1139
D +S++++ K ++ + I + EEA +++E+L V + + ++ Q D E+
Sbjct: 554 HDLQSELDKGK--------EDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEE 605
Query: 1140 PKLQVELEQE 1149
K QVEL E
Sbjct: 606 FKRQVELNSE 615
Score = 49.3 bits (116), Expect = 2e-05
Identities = 56/272 (20%), Positives = 131/272 (48%), Gaps = 32/272 (11%)
Query: 901 VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQ---- 956
++ E+EA+ +++L + LQ++ + K ++R ++ T ++E + N +
Sbjct: 409 MIKELEAR-VQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKD 467
Query: 957 ---NDYLRRRAALEKSAKKDSK--KKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDK 1011
NDY + L+ D K+ S SS IE E+ Q + LK +
Sbjct: 468 HLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIE--------ELEQNVCQLKQQ 519
Query: 1012 QQQQLLNLRQEQYYSE-KYQ-KREHIKLLIQKLT-------DVAEECQNNQLKKLKEICE 1062
Q+ L +Q+ E K+Q ++ H+K + +K D +E ++ K +E +
Sbjct: 520 LQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALK 579
Query: 1063 KEKKELKKKMDKKR-QEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIK----RLEEAQ 1117
+++++L + + +R Q + +A ++ + E +E + + ++E ++ ++ R + +
Sbjct: 580 EKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLR 639
Query: 1118 SKRQEKLVEKHKEIRQQILDEKPKLQVELEQE 1149
K+ ++ + + ++IRQ+ + +L++E EQE
Sbjct: 640 EKQSKEFLWQLEDIRQRYEQQIVELKLEHEQE 671
Score = 41.2 bits (95), Expect = 0.006
Identities = 48/231 (20%), Positives = 111/231 (48%), Gaps = 17/231 (7%)
Query: 901 VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL 960
V+ ++EAQ + +L+++ V Q+K L++ K+ +EH N+++ +
Sbjct: 722 VIADMEAQ-VHKLREELINVNSQRKQQLVELGLLREEEKQRAT--REHEIVVNKLKAESE 778
Query: 961 RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLK--------DKQ 1012
+ + L+K+ +++ E ++ IE++ A+ +Q + +L+ +
Sbjct: 779 KMKIELKKTHAAETEMTLEKANSK--LKQIEKEYTQKLAKSSQIIAELQTTISSLKEENS 836
Query: 1013 QQQLLNLRQEQYYSEKYQ--KREHIKLLIQKLTDVAEECQN--NQLKKLKEICEKEKKEL 1068
QQQL R+ Q +K++ K++ I+ Q + + +E +N NQ++ ++ + ++ E
Sbjct: 837 QQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELES 896
Query: 1069 KKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSK 1119
++++ RQE T+ K + + +E + I S +V KR Q +
Sbjct: 897 QEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEE 947
>gi|28460688 taxilin [Homo sapiens]
Length = 546
Score = 67.0 bits (162), Expect = 1e-10
Identities = 75/337 (22%), Positives = 149/337 (44%), Gaps = 24/337 (7%)
Query: 841 EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKT-----E 895
EA P E E PS+A PA ++ P+ P A G+++ ++ E
Sbjct: 24 EAGP-EGAQERPSQA--APAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLE 80
Query: 896 DLIQSVLTE----------VEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLI 945
D++ + + + + E +KS + + E +V + +
Sbjct: 81 DILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDP 140
Query: 946 KEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKL 1005
+ ++ D RR +K AK K+ + + ST E+ LAAL + + L
Sbjct: 141 NTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELL 200
Query: 1006 IDLKDKQQQ-QLLNLRQEQYYSEKYQKR-EHIKLLI--QKLTDVAEECQNNQLKKLKEIC 1061
+ ++ Q+Q +LL +Q Q EK R EH K ++ KL + E Q + +E
Sbjct: 201 EEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGV 260
Query: 1062 EKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQ 1121
++ ++E +K+ + ++T + + + E+ +R E+ + +K+L E R+
Sbjct: 261 QRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELRE 320
Query: 1122 EKL--VEKHKEIRQQILDEKPKLQVELEQEYQDKFKR 1156
E + V KHK+++QQ++D K + E+ +E +++ +R
Sbjct: 321 EHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQR 357
Score = 48.5 bits (114), Expect = 4e-05
Identities = 61/251 (24%), Positives = 113/251 (45%), Gaps = 41/251 (16%)
Query: 917 KSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKK 976
+S + ++H + +K+ + ++ + KE T+ + ND + +E+ +++SK
Sbjct: 242 ESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDI---QLQMEQHNERNSKL 298
Query: 977 KSEPSS-PDHGSSTIEQ--------DLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSE 1027
+ E + IEQ D ++ Q+L+D K +Q Q++L +E++ E
Sbjct: 299 RQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQRE 358
Query: 1028 K-----------------YQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKK 1070
K Q+ H+K + T+ EE QN L K E+ K+E++K
Sbjct: 359 KDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNT-LSKSSEVFTTFKQEMEK 417
Query: 1071 KMDK-KRQEKIT-------EAKSKDKSQMEEEKTEMIRSYIQEVVQY-IKRLEEAQSKRQ 1121
K K+ EK T E+ +K +M EEKT +R E +Q I+RLE+ Q
Sbjct: 418 MTKKIKKLEKETTMYRSRWESSNKALLEMAEEKT--VRDKELEGLQVKIQRLEKLCRALQ 475
Query: 1122 EKLVEKHKEIR 1132
+ + +K ++
Sbjct: 476 TERNDLNKRVQ 486
Score = 45.1 bits (105), Expect = 4e-04
Identities = 70/305 (22%), Positives = 122/305 (40%), Gaps = 33/305 (10%)
Query: 875 PSQALHSQPA--PGSVKAPAKTEDLI-----QSVLTEVEAQTIEELKQQKSFVKLQKKHY 927
PSQA + A PGS +AP K E L +V + +L+ S +
Sbjct: 34 PSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILSTYCVDNNQG 93
Query: 928 KEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGS 987
+D + + D K T Y+ R E + + +K EPS D +
Sbjct: 94 GPGEDGAQGEPAEPEDAEKSRT---------YVARNGEPEPTPVVNGEK--EPSKGDPNT 142
Query: 988 STIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAE 1047
I Q D + + K K + + L Q + E + L +K ++ E
Sbjct: 143 EEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLM-QTLNTLSTPEEKLAALCKKYAELLE 201
Query: 1048 ECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVV 1107
E +N+Q K+ K L+KK + QEK K+ + K E S +E+
Sbjct: 202 EHRNSQ---------KQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLE---SLCRELQ 249
Query: 1108 QYIKRLEEAQSKRQEKLVEKHKEIRQ--QILDEKPKLQVELEQEYQDKFKRLPLEILEFV 1165
++ + L+E +R + EK KE+ Q+ +LQ+E E K ++ +E+ E +
Sbjct: 250 RHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERL 309
Query: 1166 QEAMK 1170
++ ++
Sbjct: 310 KKLIE 314
Score = 36.2 bits (82), Expect = 0.20
Identities = 61/325 (18%), Positives = 135/325 (41%), Gaps = 48/325 (14%)
Query: 836 EEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTE 895
EE+++ + G+ P E + G+ TL Q L++ P A
Sbjct: 143 EEIRQSDEVGDRDHRRPQEKKKA---KGLGKEITLL----MQTLNTLSTPEEKLA----- 190
Query: 896 DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEM---KDLVKRHHKKTTDLIKEHTTKY 952
L + A+ +EE + + +KL +K ++ KD ++ H K + +
Sbjct: 191 -----ALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLC 245
Query: 953 NEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQ 1012
E+Q + + A+++ +K+ E +S H T+ D++ +
Sbjct: 246 RELQRHNRSLKEEGVQRAREEEEKRKEVTS--HFQVTLN---------------DIQLQM 288
Query: 1013 QQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKM 1072
+Q N R + E + E +K LI++ E + + K+ + + +++ + K+
Sbjct: 289 EQH--NERNSKLRQENMELAERLKKLIEQY-----ELREEHIDKVFKHKDLQQQLVDAKL 341
Query: 1073 DKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIR 1132
++ QE + EA+ + + + + E + S Q + + +K+ +E K+Q L + E
Sbjct: 342 -QQAQEMLKEAEERHQREKDFLLKEAVES--QRMCELMKQ-QETHLKQQLALYTEKFEEF 397
Query: 1133 QQILDEKPKLQVELEQEYQDKFKRL 1157
Q L + ++ +QE + K++
Sbjct: 398 QNTLSKSSEVFTTFKQEMEKMTKKI 422
>gi|239745081 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 2 [Homo sapiens]
Length = 629
Score = 66.2 bits (160), Expect = 2e-10
Identities = 105/423 (24%), Positives = 181/423 (42%), Gaps = 92/423 (21%)
Query: 845 GETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTE 904
G A S +P ++ ++ P+ P Q L P SVK ++ ++ I+S L +
Sbjct: 52 GSIHETATSGGCHSPGDSSSTSSSLHAPQSPCQELAVVPDSRSVKV-SQLKNTIKS-LKQ 109
Query: 905 VEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHH----KKTTDLI--KEHTTKYNEIQND 958
+ Q + +L+++K ++K +E++ ++R + K TDL K + E D
Sbjct: 110 QKKQVVHQLEEEKKANNEKQKAERELEVQIQRLNIQKGKLNTDLYHTKRSLRYFEEESKD 169
Query: 959 Y-------LRRRAALEKSAKK---DSKKKSEPSSPDHGSST---IEQDL---AALDAEMT 1002
L+R+ LE++ KKK+E S + T +EQ + A L A++T
Sbjct: 170 LAVRLQHSLQRKGELERALSAVTATQKKKAERFSSRSKARTEWKLEQSMREQALLKAQLT 229
Query: 1003 QKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICE 1062
Q LK+ Q L +++Y EH+K Q K +E+C
Sbjct: 230 QLKESLKEVQ------LERDEY-------AEHLK-------GERARWQQRMRKMSQEVCS 269
Query: 1063 KEKKELKKKMDKKRQEKITEAKSKDKSQMEE-------------------EKTEMIRSYI 1103
+K+ KK DK R E + + SK K+QM E ++ E + +
Sbjct: 270 LKKE---KKHDKYRVETLERSLSKLKNQMAEPLPPEPPAVPSEAELQHLRKELERVAGAL 326
Query: 1104 QEVVQYIKR---LEEAQSKR----QEKLVEKHKEIRQ--------QILDEKPKLQVELEQ 1148
Q V+Y +R L E Q +R QE+L E+ + ++Q + L+ + K ++LEQ
Sbjct: 327 QAQVEYNQRISLLNEGQKERLREQQERLPEQEERLQQLAEPQNSFKELNNENKSVLQLEQ 386
Query: 1149 EYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVN---HKTPSSEELGG 1205
+ ++ ++L E LE S+ +A LSL + PG+ + H EE
Sbjct: 387 QVKELQEKLGKERLE--------AASQQKQQLTAQLSLMALPGEGDGGGHLDSEGEEAPR 438
Query: 1206 DIP 1208
IP
Sbjct: 439 PIP 441
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 64.3 bits (155), Expect = 7e-10
Identities = 63/278 (22%), Positives = 130/278 (46%), Gaps = 14/278 (5%)
Query: 902 LTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLR 961
L E Q++E+ ++ LQ +H +E + ++ H +L KE+ N+IQ +
Sbjct: 975 LLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAE 1034
Query: 962 RRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQ 1021
+++ K+ + K + S +E +LA +AE + I L++ + QQ L+
Sbjct: 1035 ---IIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLK- 1090
Query: 1022 EQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEK-- 1079
E R I L QK+ D E Q L +L+ + EK + ++ + +E+
Sbjct: 1091 SLLEQETENLRTEISKLNQKIQDNNENYQVG-LAELRTLMTIEKDQCISELISRHEEESN 1149
Query: 1080 ITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQS----KRQEKLV---EKHKEIR 1132
I +A+ + + + E+ ++ +++++ +L+ S ++ EK+ EK++ I
Sbjct: 1150 ILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAII 1209
Query: 1133 QQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMK 1170
Q + ++ KL EQ+ + ++L E E +Q A+K
Sbjct: 1210 QNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALK 1247
Score = 55.1 bits (131), Expect = 4e-07
Identities = 71/323 (21%), Positives = 137/323 (42%), Gaps = 69/323 (21%)
Query: 903 TEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRR 962
T VE + I E + + L++KH KE+ L + K LIKE
Sbjct: 840 TAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKE--------------- 884
Query: 963 RAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQE 1022
E++ K K K E + + + A + E + +I L++++ Q+LL +
Sbjct: 885 ---TEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEK-EAVICLQNEKDQKLLEMENI 940
Query: 1023 QYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITE 1082
+ ++ C+ +LK+ +EI ++ K+L + D+K Q E
Sbjct: 941 MH---------------------SQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAE 979
Query: 1083 AKSKDKSQMEEEKTEMIRSYIQE----VVQYIKRLEEAQSKRQE---KLVEKHKEIRQQ- 1134
+S ++S ++E + + +IQE + + LEE + + Q+ ++ E H EI Q+
Sbjct: 980 LQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEK 1039
Query: 1135 -------------ILDEKPKLQVE--LEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNH 1179
+ D + KL+VE L++ D+ K L E +E +K + +++
Sbjct: 1040 EKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETE- 1098
Query: 1180 GSAPLSLSSDPGKVNHKTPSSEE 1202
+L ++ K+N K + E
Sbjct: 1099 -----NLRTEISKLNQKIQDNNE 1116
Score = 52.8 bits (125), Expect = 2e-06
Identities = 63/283 (22%), Positives = 119/283 (42%), Gaps = 72/283 (25%)
Query: 930 MKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSST 989
+ +L+ RH +++ +++K K + N +EK+ K+ + S
Sbjct: 1137 ISELISRHEEES-NILKAELNKVTSLHNQAFE----IEKNLKEQIIELQ---------SK 1182
Query: 990 IEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQY--YSEKYQKREHIKLLIQKLTDVAE 1047
++ +L+AL+ + +K+ ++K + + NL +++ S + Q RE LIQKL +
Sbjct: 1183 LDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQ---LIQKLNCEKD 1239
Query: 1048 ECQNNQLKKLK---EICEKEKKELKKKMDKK--------------------RQEKITEAK 1084
E LK+ K E+ EKE E K ++ + QEK+ E K
Sbjct: 1240 EAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEK 1299
Query: 1085 SKDKSQMEEE-----------KTEMI------------------RSYIQEVVQYIKRLEE 1115
+K Q+EE+ +T +I + I ++ +K +
Sbjct: 1300 AKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQ 1359
Query: 1116 AQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKRLP 1158
Q +R + L+E E R ++L+EK KL+ E+ + F P
Sbjct: 1360 -QQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSP 1401
>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
sapiens]
Length = 1594
Score = 64.3 bits (155), Expect = 7e-10
Identities = 63/278 (22%), Positives = 130/278 (46%), Gaps = 14/278 (5%)
Query: 902 LTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLR 961
L E Q++E+ ++ LQ +H +E + ++ H +L KE+ N+IQ +
Sbjct: 975 LLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAE 1034
Query: 962 RRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQ 1021
+++ K+ + K + S +E +LA +AE + I L++ + QQ L+
Sbjct: 1035 ---IIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLK- 1090
Query: 1022 EQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEK-- 1079
E R I L QK+ D E Q L +L+ + EK + ++ + +E+
Sbjct: 1091 SLLEQETENLRTEISKLNQKIQDNNENYQVG-LAELRTLMTIEKDQCISELISRHEEESN 1149
Query: 1080 ITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQS----KRQEKLV---EKHKEIR 1132
I +A+ + + + E+ ++ +++++ +L+ S ++ EK+ EK++ I
Sbjct: 1150 ILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAII 1209
Query: 1133 QQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMK 1170
Q + ++ KL EQ+ + ++L E E +Q A+K
Sbjct: 1210 QNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALK 1247
Score = 55.1 bits (131), Expect = 4e-07
Identities = 71/323 (21%), Positives = 137/323 (42%), Gaps = 69/323 (21%)
Query: 903 TEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRR 962
T VE + I E + + L++KH KE+ L + K LIKE
Sbjct: 840 TAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKE--------------- 884
Query: 963 RAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQE 1022
E++ K K K E + + + A + E + +I L++++ Q+LL +
Sbjct: 885 ---TEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEK-EAVICLQNEKDQKLLEMENI 940
Query: 1023 QYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITE 1082
+ ++ C+ +LK+ +EI ++ K+L + D+K Q E
Sbjct: 941 MH---------------------SQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAE 979
Query: 1083 AKSKDKSQMEEEKTEMIRSYIQE----VVQYIKRLEEAQSKRQE---KLVEKHKEIRQQ- 1134
+S ++S ++E + + +IQE + + LEE + + Q+ ++ E H EI Q+
Sbjct: 980 LQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEK 1039
Query: 1135 -------------ILDEKPKLQVE--LEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNH 1179
+ D + KL+VE L++ D+ K L E +E +K + +++
Sbjct: 1040 EKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETE- 1098
Query: 1180 GSAPLSLSSDPGKVNHKTPSSEE 1202
+L ++ K+N K + E
Sbjct: 1099 -----NLRTEISKLNQKIQDNNE 1116
Score = 52.8 bits (125), Expect = 2e-06
Identities = 63/283 (22%), Positives = 119/283 (42%), Gaps = 72/283 (25%)
Query: 930 MKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSST 989
+ +L+ RH +++ +++K K + N +EK+ K+ + S
Sbjct: 1137 ISELISRHEEES-NILKAELNKVTSLHNQAFE----IEKNLKEQIIELQ---------SK 1182
Query: 990 IEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQY--YSEKYQKREHIKLLIQKLTDVAE 1047
++ +L+AL+ + +K+ ++K + + NL +++ S + Q RE LIQKL +
Sbjct: 1183 LDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQ---LIQKLNCEKD 1239
Query: 1048 ECQNNQLKKLK---EICEKEKKELKKKMDKK--------------------RQEKITEAK 1084
E LK+ K E+ EKE E K ++ + QEK+ E K
Sbjct: 1240 EAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEK 1299
Query: 1085 SKDKSQMEEE-----------KTEMI------------------RSYIQEVVQYIKRLEE 1115
+K Q+EE+ +T +I + I ++ +K +
Sbjct: 1300 AKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQ 1359
Query: 1116 AQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKRLP 1158
Q +R + L+E E R ++L+EK KL+ E+ + F P
Sbjct: 1360 -QQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSP 1401
>gi|239745085 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 3 [Homo sapiens]
Length = 601
Score = 63.2 bits (152), Expect = 1e-09
Identities = 93/382 (24%), Positives = 165/382 (43%), Gaps = 81/382 (21%)
Query: 845 GETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTE 904
G A S +P ++ ++ P+ P Q L P SVK ++ ++ I+S L +
Sbjct: 52 GSIHETATSGGCHSPGDSSSTSSSLHAPQSPCQELAVVPDSRSVKV-SQLKNTIKS-LKQ 109
Query: 905 VEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHH----KKTTDLI--KEHTTKYNEIQND 958
+ Q + +L+++K ++K +E++ ++R + K TDL K + E D
Sbjct: 110 QKKQVVHQLEEEKKANNEKQKAERELEVQIQRLNIQKGKLNTDLYHTKRSLRYFEEESKD 169
Query: 959 Y-------LRRRAALEKSAKK---DSKKKSEPSSPDHGSST---IEQDL---AALDAEMT 1002
L+R+ LE++ KKK+E S + T +EQ + A L A++T
Sbjct: 170 LAVRLQHSLQRKGELERALSAVTATQKKKAERFSSRSKARTEWKLEQSMREQALLKAQLT 229
Query: 1003 QKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICE 1062
Q LK+ Q L +++Y EH+K Q K +E+C
Sbjct: 230 QLKESLKEVQ------LERDEY-------AEHLK-------GERARWQQRMRKMSQEVCS 269
Query: 1063 KEKKELKKKMDKKRQEKITEAKSKDKSQMEE-------------------EKTEMIRSYI 1103
+K+ KK DK R E + + SK K+QM E ++ E + +
Sbjct: 270 LKKE---KKHDKYRVETLERSLSKLKNQMAEPLPPEPPAVPSEAELQHLRKELERVAGAL 326
Query: 1104 QEVVQYIKR---LEEAQSKR----QEKLVEKHKEIRQ--------QILDEKPKLQVELEQ 1148
Q V+Y +R L E Q +R QE+L E+ + ++Q + L+ + K ++LEQ
Sbjct: 327 QAQVEYNQRISLLNEGQKERLREQQERLPEQEERLQQLAEPQNSFKELNNENKSVLQLEQ 386
Query: 1149 EYQDKFKRLPLEILEFVQEAMK 1170
+ ++ ++L + V A K
Sbjct: 387 QVKELQEKLGKRLAHLVASAQK 408
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 62.0 bits (149), Expect = 3e-09
Identities = 72/351 (20%), Positives = 157/351 (44%), Gaps = 17/351 (4%)
Query: 814 IRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEAR----TTPAENGVNHTTT 869
++++ EQ ++ A L++EE+ +E E + + HT
Sbjct: 831 LQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY 890
Query: 870 LTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELK-QQKSFVKLQKKHYK 928
P Q Q + + E+ + E E Q EE + QQ+ L+++ K
Sbjct: 891 AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK 950
Query: 929 EMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSS------ 982
+ +R ++K L ++ E RRR EK +++ + + E
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEK--RRRQEREKKYREEEELQQEEEQLLREER 1008
Query: 983 PDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKL 1042
E+ D ++ L+++++++ L R+ QY E+ ++E +LL ++
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068
Query: 1043 TDVAEECQNNQLKKLKEICEKEKKELKKKMDK-KRQEKITEAKSKDKSQMEEE---KTEM 1098
+ Q +K +E+ ++E++ L+++ +K +RQE+ + + +++ Q EEE + E
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Query: 1099 IRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQE 1149
+ QE+ + + EE Q + ++ L E+ ++ R+Q L+ + + + EL+QE
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179
Score = 58.9 bits (141), Expect = 3e-08
Identities = 51/256 (19%), Positives = 125/256 (48%), Gaps = 7/256 (2%)
Query: 907 AQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAAL 966
AQ ++E + + +++ ++ +D R + + HT + LR+ L
Sbjct: 846 AQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL 905
Query: 967 EKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYS 1026
+ +++ +++ ++ L E Q L + ++K+++Q R+ QY
Sbjct: 906 LQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE---RERQYRK 962
Query: 1027 EKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDK-KRQEKITEAKS 1085
+K +++ +LL ++ + + + ++ +E+ ++E++ L+++ +K +RQE + +
Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 1086 KDKSQMEEE---KTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKL 1142
KD+ Q EEE + E + +QE + + EE Q + ++ L E+ + R+Q L+ + +
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 1143 QVELEQEYQDKFKRLP 1158
+ EL+QE + + P
Sbjct: 1083 EEELQQEEEQLLREEP 1098
Score = 57.4 bits (137), Expect = 8e-08
Identities = 55/276 (19%), Positives = 136/276 (49%), Gaps = 34/276 (12%)
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSA 970
+E ++++ ++KL+++ +E ++ ++ ++ + +E K E + + L++R E+
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE-EEERLQQRLRSEQQL 538
Query: 971 KKDSKKKSEPSSPDHGSSTIEQD-----LAALDAEMTQKLIDLKDKQQQQLLNLRQEQYY 1025
+++ +++ E +EQ+ L E +L+ +++++QQ L QE+
Sbjct: 539 RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERL 598
Query: 1026 SEKYQKREHIKLLIQK-------LTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQE 1078
++ KRE ++ L Q+ + EE + QL K +E E+ +++L+++ ++R++
Sbjct: 599 EQRL-KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Query: 1079 KITEAKSKDKSQMEEEKTEM-IRSYIQEVVQYIKRLEEAQSKRQEKL----------VEK 1127
++ K + EEE+ E ++ +E + + EE Q + +E++ +E
Sbjct: 658 RL-------KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710
Query: 1128 HKEIRQQILDEKPKLQ--VELEQEYQDKFKRLPLEI 1161
+ RQ + +P+ Q QE ++K +R E+
Sbjct: 711 EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL 746
Score = 57.0 bits (136), Expect = 1e-07
Identities = 48/251 (19%), Positives = 134/251 (53%), Gaps = 17/251 (6%)
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSA 970
EE K+Q+ + +++ KE++ L + + + ++ + + +Q D RRR+ ++
Sbjct: 814 EEEKEQRR--RQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871
Query: 971 KK------DSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQY 1024
+K + +K+ + + +++ L + ++ +L+ +++++ QE+
Sbjct: 872 QKWRWQLEEERKRRRHTL--YAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ 929
Query: 1025 YSEKYQ-KREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEA 1083
Y E+ Q ++E +LL ++ + + Q +K K++ +KE++ L ++ +K+R+++ E
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE-REK 988
Query: 1084 KSKDKSQMEEEKTEMIRS-----YIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDE 1138
K +++ ++++E+ +++R QE + ++ +E Q + ++ L E+ ++ R Q +
Sbjct: 989 KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERER 1048
Query: 1139 KPKLQVELEQE 1149
+ + + EL+QE
Sbjct: 1049 QYREEEELQQE 1059
Score = 54.7 bits (130), Expect = 5e-07
Identities = 76/352 (21%), Positives = 157/352 (44%), Gaps = 46/352 (13%)
Query: 821 EQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALH 880
E R +Q EEE+++E + + E P + R E L + Q L
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEE--QLLREEPEKRRRQERERQCREEEELQQEE-EQLLR 1125
Query: 881 SQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEE--LKQQKSFVKLQK--KHYKEMKDLVKR 936
+ + + ++L + E E Q EE L+++ + Q+ + Y+E ++L +
Sbjct: 1126 EE------REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179
Query: 937 HHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAA 996
+ L++E K + + R L++ +K + + S E++ A
Sbjct: 1180 EEQ----LLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAV 1235
Query: 997 LDA---------EMTQKLID--LKDKQQQQ-LLNLRQEQYYSEKYQKREHIKLLIQKLTD 1044
D E ++L D L+D+Q QQ L +L EQ ++ Q+R + + +
Sbjct: 1236 RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE 1295
Query: 1045 VA--EECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSY 1102
E + + K+ ++EK+ L+++ ++KR+ + T+ K +++ Q+ +E+ E
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE----- 1350
Query: 1103 IQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKF 1154
Q ++R E + R+E+L +H+E ++ L+E+ +L+ QE + KF
Sbjct: 1351 -----QPLRRQERDRKFREEEL--RHQEQGRKFLEEEQRLR---RQERERKF 1392
Score = 54.3 bits (129), Expect = 7e-07
Identities = 42/211 (19%), Positives = 110/211 (52%), Gaps = 7/211 (3%)
Query: 945 IKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQK 1004
++E + + R + L + +K+ +++ + +E++ E Q+
Sbjct: 790 LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER-EKELQFLEEEEQLQRRERAQQ 848
Query: 1005 LIDLKDK-QQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEK 1063
L + +D Q+ Q QEQ +K++ + + ++ T A+ QL+K +++ ++
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 1064 EKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRS-----YIQEVVQYIKRLEEAQS 1118
E++EL+++ +KR+ + E + +++ Q+++E+ +++R QE + ++ ++ Q
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ 968
Query: 1119 KRQEKLVEKHKEIRQQILDEKPKLQVELEQE 1149
K ++ L E+ ++ R+Q ++K + + EL+QE
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEEELQQE 999
Score = 53.9 bits (128), Expect = 9e-07
Identities = 44/249 (17%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSA 970
EE K Q+ + Q++ +E + L K ++ +E + ++ + RR E+
Sbjct: 256 EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315
Query: 971 KKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLI--DLKDKQQQQLLNLRQEQYYSEK 1028
++ +++ + + EQ L E ++ + + ++++++Q L QE+ E+
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 1029 YQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDK 1088
+RE Q+L + + QL++ +++ + +++L+++ +R++++ + +++
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQL--RREQQLRREQQLRREQQLRREQEEER 433
Query: 1089 SQM---EEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEK-PKLQV 1144
+ +E + + ++ +E ++KR EE + QE+ ++ K +++ E+ KL+
Sbjct: 434 HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 1145 ELEQEYQDK 1153
E +E Q++
Sbjct: 494 EERREQQER 502
Score = 51.6 bits (122), Expect = 4e-06
Identities = 49/257 (19%), Positives = 133/257 (51%), Gaps = 19/257 (7%)
Query: 895 EDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNE 954
E L + L E+ + EE +QQ+ + Q + ++E ++ K K+ T L KE +
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRR--ERQDRVFQEEEE--KEWRKRETVLRKEE----EK 259
Query: 955 IQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQ 1014
+Q + +R+ L++ ++ K + + + +Q + ++ +K + + +QQ+
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Query: 1015 QLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDK 1074
+ R++Q E+ ++R Q+L EE + QL++ +E E+ +++L+++ ++
Sbjct: 320 ER---REQQERREQQEERRE-----QQLRREQEERREQQLRREQEE-ERREQQLRREQEE 370
Query: 1075 KRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQ 1134
+R+E+ + + + + + + + +R ++ ++ ++L Q R+E+ + + +++R++
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRR--EQQLRREQQLRREQQLRREQQLRREQQLRRE 428
Query: 1135 ILDEKPKLQVELEQEYQ 1151
+E+ + + E E+ Q
Sbjct: 429 QEEERHEQKHEQERREQ 445
Score = 50.8 bits (120), Expect = 8e-06
Identities = 51/268 (19%), Positives = 131/268 (48%), Gaps = 25/268 (9%)
Query: 892 AKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTK 951
A+ E L E E EE +++ ++L++K +E + + ++ D + +
Sbjct: 188 AEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQ----QQRRERQDRVFQE--- 240
Query: 952 YNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDK 1011
E + ++ +R L K ++ K + E E+ L L+ + ++ +++
Sbjct: 241 --EEEKEWRKRETVLRK---EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ 295
Query: 1012 QQQ------QLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEK 1065
QQQ QL ++E+ ++ ++RE Q+ + EE + QL++ +E E+ +
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQ-----QERREQQEERREQQLRREQE--ERRE 348
Query: 1066 KELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLV 1125
++L+++ +++R+E+ + +++ + ++ + E Q++ + + E Q +R+++L
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408
Query: 1126 EKHKEIRQQILDEKPKLQVELEQEYQDK 1153
+ + R+Q L + +L+ E E+E ++
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQ 436
Score = 50.4 bits (119), Expect = 1e-05
Identities = 50/258 (19%), Positives = 130/258 (50%), Gaps = 13/258 (5%)
Query: 904 EVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRR 963
E E + +E ++++ + Q++ +E + ++ ++ L +E + E Q +
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Query: 964 AALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQ 1023
E+ +++ + + E EQ L + ++ ++ +++Q ++ LR+EQ
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRR-EQQLRREQQLRREQQLRREQQLRREQ 429
Query: 1024 YYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEI----CEKEKKELKKKMDKKRQEK 1079
E+++++ + Q+L EE + + LK+ +E E+ K++LK+ +++R+E+
Sbjct: 430 E-EERHEQKHEQERREQRLKREQEE-RRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 1080 ITEAKSKDKSQMEEEKTEMIRSYIQE-VVQYIKRLEEAQSKRQ-----EKLVEKHKEIRQ 1133
+ + +++ + +E + + +R +E Q +KR EE + +Q ++L + +E R+
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Query: 1134 QILDEKPKLQVELEQEYQ 1151
Q+L + + ++E E+ Q
Sbjct: 548 QLLKREEEKRLEQERREQ 565
Score = 50.4 bits (119), Expect = 1e-05
Identities = 50/271 (18%), Positives = 134/271 (49%), Gaps = 22/271 (8%)
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLR--RRAALEK 968
E +Q + KLQ+K + + + ++ ++ + + + + LR R +
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014
Query: 969 SAKKDSKKKSEPSSPDHGSSTIEQDLAAL-DAEMTQKLIDLKDKQQQQLLN----LRQEQ 1023
++ +KK E + E++ L + E + + ++++QLL R+ Q
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQ 1074
Query: 1024 YYSEKYQKREHI-----KLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQE 1078
+Y+K E + +LL ++ + + Q ++ +E+ ++E++ L+++ +K+R++
Sbjct: 1075 ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ 1134
Query: 1079 KITEAKSKDKSQMEEEKTEMIRS-----YIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQ 1133
++ E + +++ ++++E+ +++R QE+ + + EE Q + ++ L E+ ++ RQ
Sbjct: 1135 EL-ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193
Query: 1134 ----QILDEKPKLQVELEQEYQDKFKRLPLE 1160
Q +E+ + + +Q Y+D+ +R L+
Sbjct: 1194 ERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224
Score = 50.4 bits (119), Expect = 1e-05
Identities = 56/278 (20%), Positives = 133/278 (47%), Gaps = 25/278 (8%)
Query: 906 EAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAA 965
E Q ++E ++Q ++ Q++ K ++ ++ + L +E + E + +L+
Sbjct: 1341 EEQLLQEREEQP--LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 966 LEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYY 1025
L ++ ++ D EQ L+ + + ++++QQ R+ ++
Sbjct: 1399 LRCQEREQQLRQDR----DRKFREEEQQLSRQERDRK-----FREEEQQVRRQERERKFL 1449
Query: 1026 SEKYQKRE--HIKLLIQK-LTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITE 1082
E+ Q R+ H K ++ L EE Q ++ ++ ++ E+E++ +++ D+K +E+
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509
Query: 1083 AKSKDKSQMEEE----KTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDE 1138
++ ++ +EEE + + R ++QE Q ++R E Q +RQ++ ++ +Q+ E
Sbjct: 1510 SQEPERKFLEEEQQLHRQQRQRKFLQE-EQQLRRQERGQQRRQDR--DRKFREEEQLRQE 1566
Query: 1139 KPKLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISED 1176
+ + Q+ QE KF+ LE + ++ + K ED
Sbjct: 1567 REEQQLS-RQERDRKFR---LEEQKVRRQEQERKFMED 1600
Score = 50.1 bits (118), Expect = 1e-05
Identities = 56/289 (19%), Positives = 136/289 (47%), Gaps = 19/289 (6%)
Query: 873 KPPSQALHSQPAPGS-VKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMK 931
+P + L +P K + +L + + + +E+ +Q+ +L ++ + +
Sbjct: 123 EPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQE 182
Query: 932 DLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAK-KDSKKKSEPSSPDHGSSTI 990
+R ++ K H T+ + LRRR LE K ++ K++ D +
Sbjct: 183 REERRAEEEQLQSCKGHETEEFP-DEEQLRRRELLELRRKGREEKQQQRRERQDR----V 237
Query: 991 EQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKL--TDVAEE 1048
Q+ + + ++ ++++ Q+ RQ + E+ Q R KL Q+L EE
Sbjct: 238 FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLR---KLERQELRRERQEEE 294
Query: 1049 CQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQE-VV 1107
Q +L++ +++ K+++E +++ +++R+++ + + Q EE + + +R +E
Sbjct: 295 QQQQRLRREQQLRRKQEEERREQQEERREQQ------ERREQQEERREQQLRREQEERRE 348
Query: 1108 QYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKR 1156
Q ++R +E + + Q+ E+ +E R+Q L + +L+ E + + + +R
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRR 397
Score = 50.1 bits (118), Expect = 1e-05
Identities = 41/191 (21%), Positives = 96/191 (50%), Gaps = 21/191 (10%)
Query: 991 EQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQK--------- 1041
E+ L + T++ D + ++++LL LR++ ++ Q+RE + Q+
Sbjct: 190 EEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR 249
Query: 1042 ---LTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDK----SQMEEE 1094
L E+ Q + ++ +E+ E+E++ K + + R+E+ E + + + Q+ +
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK 309
Query: 1095 KTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQIL-----DEKPKLQVELEQE 1149
+ E R +E + +R E+ + +R+++L + +E R+Q L +E+ + Q+ EQE
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE 369
Query: 1150 YQDKFKRLPLE 1160
+ + ++L E
Sbjct: 370 EERREQQLRRE 380
Score = 48.5 bits (114), Expect = 4e-05
Identities = 58/282 (20%), Positives = 132/282 (46%), Gaps = 18/282 (6%)
Query: 906 EAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHH---KKTTDLIKEHTTKYNEIQ---NDY 959
E Q E ++++ +L+++ + + ++R ++ L +E + E Q
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382
Query: 960 LRRRAAL--EKSAKKDSKKKSEPSSPDHGSSTIEQDLAA---LDAEMTQKLIDLKDKQQQ 1014
LRR L E+ +++ + + E EQ L L E ++ + K +Q++
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442
Query: 1015 QLLNLRQEQYYSEKYQKREHI------KLLIQKLTDVAEECQNNQLKKLKEICEKEKKEL 1068
+ L++EQ + KRE + Q+L EE + + KL+E +E++E
Sbjct: 443 REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502
Query: 1069 KKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKH 1128
+++ ++ QE+ E + K + + EE + +RS Q + +R E+ + +EK +E+
Sbjct: 503 REQQLRREQEERREQRLK-RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561
Query: 1129 KEIRQQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMK 1170
+ ++ +++ + L++E + + +RL E E +++ +K
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603
Score = 47.4 bits (111), Expect = 8e-05
Identities = 43/232 (18%), Positives = 116/232 (50%), Gaps = 8/232 (3%)
Query: 902 LTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLR 961
L + E Q + E +++K ++ +++ Y+E ++L + + + + T + E++ Y R
Sbjct: 1026 LQQEEEQLLRE-EREKRRLQERERQYREEEELQQEEEQLLGE--ERETRRRQELERQY-R 1081
Query: 962 RRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQ 1021
+ L++ ++ +++ E ++ L E Q L + ++K+++Q L +
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREE-EELQQEEEQLLREEREKRRRQEL---E 1137
Query: 1022 EQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKIT 1081
QY E+ ++E +LL ++ + Q ++ +E+ ++E++ L+++ +K+RQE+
Sbjct: 1138 RQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197
Query: 1082 EAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQ 1133
+ + +++ Q ++ K + +++ E+ + R K+ K +E Q
Sbjct: 1198 QYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQ 1249
Score = 47.0 bits (110), Expect = 1e-04
Identities = 50/271 (18%), Positives = 130/271 (47%), Gaps = 15/271 (5%)
Query: 906 EAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAA 965
E Q ++E ++Q+ + + + ++E + ++R ++ L +E + E++ + R
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF-REEEQ 1730
Query: 966 LEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYY 1025
L + +++ ++ E + + + ++ ++ D K ++++QL R+EQ
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPERE--EQQLRRQERDRKFREEEQLRQEREEQQL 1788
Query: 1026 SEKYQKREHIKLLIQKLTDVAEECQ-NNQLKKLKEICEKEKKELKKKMDKKRQEKITEAK 1084
+ R+ + ++L EE Q Q + K E+E+ +L+++ + RQE+ + +
Sbjct: 1789 RSQESDRKFREE--EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR 1846
Query: 1085 SKDKSQMEEEKTEMIRSYIQEVVQ-----YIKRLEEAQSKRQEKLVEKHKEIRQQILDEK 1139
++++ +E+ + QE Q ++L E +RQ+K ++H+++ +I ++
Sbjct: 1847 AEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV-GEIKSQE 1905
Query: 1140 PKLQVELEQEYQDKFKRLPLE---ILEFVQE 1167
K L + +F +P+ + E++QE
Sbjct: 1906 GKGHGRLLEPGTHQFASVPVRSSPLYEYIQE 1936
Score = 44.7 bits (104), Expect = 5e-04
Identities = 54/266 (20%), Positives = 123/266 (46%), Gaps = 20/266 (7%)
Query: 904 EVEAQTIEELKQQKSFVKLQKKHYKE-MKDLVKRHH---KKTTDLIKEHTTKYNE-IQND 958
E Q + +Q++ +L+++ +E ++ +KR H ++ +L +E + E I++
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700
Query: 959 YLRRRAALEKSAK-KDSKKKSEPSSPDHGSSTIEQD--LAALDAEMTQKLIDLKDKQQQQ 1015
+ + LE A + SK S P + EQ+ ++E+ + + +QQQ+
Sbjct: 701 IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQE 760
Query: 1016 LLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKK 1075
R + + +K E + + + E Q + + +E ++E++ L ++ +K+
Sbjct: 761 EEQRRDFTWQWQAEEKSERGRQRLSARPPLRE--QRERQLRAEERQQREQRFLPEEEEKE 818
Query: 1076 RQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEK----------LV 1125
++ + + K+ +EEE+ R Q++ + L+E Q +R+ + +
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Query: 1126 EKHKEIRQQILDEKPKLQVELEQEYQ 1151
E+ ++ R+ L KP LQ +L +E Q
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQ 904
Score = 42.4 bits (98), Expect = 0.003
Identities = 49/281 (17%), Positives = 134/281 (47%), Gaps = 33/281 (11%)
Query: 904 EVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRR 963
E + + EEL+Q++ + L+++ K + ++R +++ ++ +E E RRR
Sbjct: 1107 ERQCREEEELQQEEEQL-LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK--RRR 1163
Query: 964 AALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQ 1023
LE+ +++ + + E E+ L + E ++ + + +++++L +++Q
Sbjct: 1164 QELERQYREEEELQQE-----------EEQLLREEQEKRRQERERQYREEEELQRQKRKQ 1212
Query: 1024 YYSE-------KYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKE-------LK 1069
Y + K+Q + ++ + +N Q ++L++ ++++ L
Sbjct: 1213 RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG 1272
Query: 1070 KKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHK 1129
++ ++ R+++ + +D+ EEE+ E +E + +R ++Q ++Q E+ +
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLER-----EEQKEAKRRDRKSQEEKQLLREEREE 1327
Query: 1130 EIRQQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMK 1170
+ R+Q D K + + +L QE +++ R +F +E ++
Sbjct: 1328 KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR 1368
Score = 42.4 bits (98), Expect = 0.003
Identities = 45/255 (17%), Positives = 122/255 (47%), Gaps = 17/255 (6%)
Query: 899 QSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQND 958
+ +L E E Q + ++ + F++ + + ++ ++ RH + +E E +
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRK--FREEEQLLQEGEEQ 1682
Query: 959 YLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLN 1018
LRR+ K +++ + + + E+ + ++ ++ ++ K ++++QL
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQER---------ERKFLQEEQQLRRQELERKFREEEQL-- 1731
Query: 1019 LRQEQYYSEKYQKREHIKLLIQK-LTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQ 1077
RQE + ++ + K+L ++ L EE Q + ++ ++ E+E+ +++ + R
Sbjct: 1732 -RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS 1790
Query: 1078 EKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILD 1137
++ ++ K +++ Q+ +E+ E Q +Y E+ Q + QE+ + + ++ RQ +
Sbjct: 1791 QE-SDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD-RQYRAE 1848
Query: 1138 EKPKLQVELEQEYQD 1152
E+ Q + +E Q+
Sbjct: 1849 EQFATQEKSRREEQE 1863
Score = 41.6 bits (96), Expect = 0.005
Identities = 57/242 (23%), Positives = 115/242 (47%), Gaps = 39/242 (16%)
Query: 913 LKQQKSFVKLQKKHYKEMKDLVK-RHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAK 971
L++QK V+ Q++ K M+D + R + L +E K+ E ++ L + ++ +
Sbjct: 1583 LEEQK--VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE--DEQLLQEREEQQLHR 1638
Query: 972 KDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQK 1031
++ +K P EQ L + D K ++++QLL +EQ + +
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQL--------RHDRDRKFREEEQLLQEGEEQQLRRQERD 1690
Query: 1032 REHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQM 1091
R+ + + QL++ E+E+K L+++ +RQE E K +++ Q+
Sbjct: 1691 RKFRE-------------EEQQLRRQ----ERERKFLQEEQQLRRQE--LERKFREEEQL 1731
Query: 1092 EEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQ 1151
+E TE + QE +Y K LEE Q + + + +++R+Q D K + + +L QE +
Sbjct: 1732 RQE-TEQEQLRRQE--RYRKILEEEQLRPERE----EQQLRRQERDRKFREEEQLRQERE 1784
Query: 1152 DK 1153
++
Sbjct: 1785 EQ 1786
Score = 39.3 bits (90), Expect = 0.023
Identities = 54/276 (19%), Positives = 126/276 (45%), Gaps = 25/276 (9%)
Query: 899 QSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQND 958
Q + + + E +QQ + ++K +E + L + H+K +E E +
Sbjct: 1421 QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK----FREEEQLLQEREEQ 1476
Query: 959 YLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKD---KQQQQ 1015
L R+ K +++ + + + + EQ+L + + E +K ++ + +QQ+Q
Sbjct: 1477 QLHRQERDRKFLEEEQQLRRQ----ERDRKFREQELRSQEPE--RKFLEEEQQLHRQQRQ 1530
Query: 1016 LLNLRQEQYYSEK---YQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKM 1072
L++EQ + Q+R+ ++ + +E + QL + E+++K ++
Sbjct: 1531 RKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ----ERDRKFRLEEQ 1586
Query: 1073 DKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIR 1132
+RQE+ + ++ +E + +R QE + + E+ +R+E+ + + + R
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLR---QERDRKFREDEQLLQEREEQQLHRQERDR 1643
Query: 1133 QQILDEKPKL-QVELEQEYQDKFKRLPLEILEFVQE 1167
+ L+E+P+L + E EQ+ + R E + +QE
Sbjct: 1644 -KFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Score = 37.4 bits (85), Expect = 0.088
Identities = 34/159 (21%), Positives = 86/159 (54%), Gaps = 8/159 (5%)
Query: 1000 EMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKE 1059
E ++ + +++QQ++ L +E+ EK Q+R + ++L + EE Q + ++ ++
Sbjct: 792 EQRERQLRAEERQQREQRFLPEEE---EKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 1060 ICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRS-YIQEVVQYIKRLEEAQS 1118
+ ++E+ L++ +++R ++ K + Q+EEE+ + Y + +Q ++L + Q
Sbjct: 849 L-QEEEDGLQEDQERRRSQE-QRRDQKWRWQLEEERKRRRHTLYAKPALQ--EQLRKEQQ 904
Query: 1119 KRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKRL 1157
QE+ E +E R++ ++ + Q E++ Q + ++L
Sbjct: 905 LLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQL 943
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,132,550
Number of Sequences: 37866
Number of extensions: 2292882
Number of successful extensions: 22023
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 322
Number of HSP's successfully gapped in prelim test: 1176
Number of HSP's that attempted gapping in prelim test: 12106
Number of HSP's gapped (non-prelim): 6474
length of query: 1216
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1102
effective length of database: 13,930,794
effective search space: 15351734988
effective search space used: 15351734988
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.