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Search of human proteins with 120587027
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
(1352 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens] 2724 0.0
gi|148612811 ubiquitin specific protease 43 [Homo sapiens] 716 0.0
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens] 165 3e-40
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens] 165 3e-40
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 161 3e-39
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens] 149 2e-35
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens] 139 1e-32
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 130 9e-30
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 130 9e-30
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 130 9e-30
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 118 4e-26
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens] 118 4e-26
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens] 118 4e-26
gi|183396780 ubiquitin specific protease 20 [Homo sapiens] 116 2e-25
gi|183397136 ubiquitin specific protease 20 [Homo sapiens] 116 2e-25
gi|183397134 ubiquitin specific protease 20 [Homo sapiens] 116 2e-25
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 111 4e-24
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 111 4e-24
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 103 9e-22
gi|22550104 ubiquitin specific protease 32 [Homo sapiens] 103 9e-22
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 103 1e-21
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 101 4e-21
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 97 8e-20
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens] 97 1e-19
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 95 4e-19
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 95 4e-19
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 88 5e-17
gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens] 86 3e-16
gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens] 86 3e-16
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 84 7e-16
>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
Length = 1352
Score = 2724 bits (7061), Expect = 0.0
Identities = 1352/1352 (100%), Positives = 1352/1352 (100%)
Query: 1 MSKVTAPGSGPPAAASGKEKRSFSKRLFRSGRAGGGGAGGPGASGPAAPSSPSSPSSARS 60
MSKVTAPGSGPPAAASGKEKRSFSKRLFRSGRAGGGGAGGPGASGPAAPSSPSSPSSARS
Sbjct: 1 MSKVTAPGSGPPAAASGKEKRSFSKRLFRSGRAGGGGAGGPGASGPAAPSSPSSPSSARS 60
Query: 61 VGSFMSRVLKTLSTLSHLSSEGAAPDRGGLRSCFPPGPAAAPTPPPCPPPPASPAPPACA 120
VGSFMSRVLKTLSTLSHLSSEGAAPDRGGLRSCFPPGPAAAPTPPPCPPPPASPAPPACA
Sbjct: 61 VGSFMSRVLKTLSTLSHLSSEGAAPDRGGLRSCFPPGPAAAPTPPPCPPPPASPAPPACA 120
Query: 121 AEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGA 180
AEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGA
Sbjct: 121 AEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGA 180
Query: 181 QGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRV 240
QGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRV
Sbjct: 181 QGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRV 240
Query: 241 HEDLNHSVKQSGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSN 300
HEDLNHSVKQSGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSN
Sbjct: 241 HEDLNHSVKQSGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSN 300
Query: 301 TFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIP 360
TFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIP
Sbjct: 301 TFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIP 360
Query: 361 TDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETPEIFRPEGILSQRGIHLNNNLN 420
TDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETPEIFRPEGILSQRGIHLNNNLN
Sbjct: 361 TDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETPEIFRPEGILSQRGIHLNNNLN 420
Query: 421 HLKFGLDYHRLSSPTQTAAKQGKMDSPTSRAGSDKIVLLVCNRACTGQQGKRFGLPFVLH 480
HLKFGLDYHRLSSPTQTAAKQGKMDSPTSRAGSDKIVLLVCNRACTGQQGKRFGLPFVLH
Sbjct: 421 HLKFGLDYHRLSSPTQTAAKQGKMDSPTSRAGSDKIVLLVCNRACTGQQGKRFGLPFVLH 480
Query: 481 LEKTIAWDLLQKEILEKMKYFLRPTVCIQVCPFSLRVVSVVGITYLLPQEEQPLCHPIVE 540
LEKTIAWDLLQKEILEKMKYFLRPTVCIQVCPFSLRVVSVVGITYLLPQEEQPLCHPIVE
Sbjct: 481 LEKTIAWDLLQKEILEKMKYFLRPTVCIQVCPFSLRVVSVVGITYLLPQEEQPLCHPIVE 540
Query: 541 RALKSCGPGGTAHVKLVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQ 600
RALKSCGPGGTAHVKLVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQ
Sbjct: 541 RALKSCGPGGTAHVKLVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQ 600
Query: 601 CFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQN 660
CFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQN
Sbjct: 601 CFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQN 660
Query: 661 MVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQ 720
MVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQ
Sbjct: 661 MVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQ 720
Query: 721 GGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRTAIPSWSANSSVAGS 780
GGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRTAIPSWSANSSVAGS
Sbjct: 721 GGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRTAIPSWSANSSVAGS 780
Query: 781 TSSSLCEHWVSRLPGSKPASVTSAASSRRTSLASLSESVEMTGERSEDDGGFSTRPFVRS 840
TSSSLCEHWVSRLPGSKPASVTSAASSRRTSLASLSESVEMTGERSEDDGGFSTRPFVRS
Sbjct: 781 TSSSLCEHWVSRLPGSKPASVTSAASSRRTSLASLSESVEMTGERSEDDGGFSTRPFVRS 840
Query: 841 VQRQSLSSRSSVTSPLAVNENCMRPSWSLSAKLQMRSNSPSRFSGDSPIHSSASTLEKIG 900
VQRQSLSSRSSVTSPLAVNENCMRPSWSLSAKLQMRSNSPSRFSGDSPIHSSASTLEKIG
Sbjct: 841 VQRQSLSSRSSVTSPLAVNENCMRPSWSLSAKLQMRSNSPSRFSGDSPIHSSASTLEKIG 900
Query: 901 EAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVFKDESDTRRLNS 960
EAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVFKDESDTRRLNS
Sbjct: 901 EAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVFKDESDTRRLNS 960
Query: 961 SVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSHPGSLAKKPE 1020
SVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSHPGSLAKKPE
Sbjct: 961 SVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSHPGSLAKKPE 1020
Query: 1021 STTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKPSRSRSKADSS 1080
STTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKPSRSRSKADSS
Sbjct: 1021 STTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKPSRSRSKADSS 1080
Query: 1081 SRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASSTSAKKASGPATRS 1140
SRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASSTSAKKASGPATRS
Sbjct: 1081 SRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASSTSAKKASGPATRS 1140
Query: 1141 PFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPNSPRVSQARAGEGRGAGKHVRSSS 1200
PFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPNSPRVSQARAGEGRGAGKHVRSSS
Sbjct: 1141 PFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPNSPRVSQARAGEGRGAGKHVRSSS 1200
Query: 1201 MASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETRRSTDLGKTALLSKKAGGSSVK 1260
MASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETRRSTDLGKTALLSKKAGGSSVK
Sbjct: 1201 MASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETRRSTDLGKTALLSKKAGGSSVK 1260
Query: 1261 SVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPASAKHSLLSARKSKSSQLDSGV 1320
SVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPASAKHSLLSARKSKSSQLDSGV
Sbjct: 1261 SVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPASAKHSLLSARKSKSSQLDSGV 1320
Query: 1321 PSSPGGRQSAEKSSKKLSSSMQTSARPSQKPQ 1352
PSSPGGRQSAEKSSKKLSSSMQTSARPSQKPQ
Sbjct: 1321 PSSPGGRQSAEKSSKKLSSSMQTSARPSQKPQ 1352
>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
Length = 1123
Score = 716 bits (1849), Expect = 0.0
Identities = 399/837 (47%), Positives = 517/837 (61%), Gaps = 59/837 (7%)
Query: 40 GPGASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGLRSCFPPGPA 99
GPG + P +P P RS+ SR L L + S P G G A
Sbjct: 4 GPGDAAGGGPLAPR-PRRRRSLRRLFSRFLLALGSRSRPGDSPPRPQPGHCDGDGEGGFA 62
Query: 100 AAPTPPPCPPP------PASPAP----PACAAEPVPGVAGLRNHGNTCFMNATLQCLSNT 149
AP P P P P P P PA PG GL+NHGNTCFMNA +QCLSNT
Sbjct: 63 CAPGPVPAAPGSPGEERPPGPQPQLQLPAGDGARPPGAQGLKNHGNTCFMNAVVQCLSNT 122
Query: 150 ELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQHSRD 209
+L AE+LALG+YRA A G+ EVTEQLA LVRALWT EYTPQ S +
Sbjct: 123 DLLAEFLALGRYRA----------------APGRAEVTEQLAALVRALWTREYTPQLSAE 166
Query: 210 FKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHS----VKQSGQPPLKPPSETDMM 265
FK VSK Q++GNSQHDA EFLLWLLDRVHEDL S V + P SE +
Sbjct: 167 FKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVSEKLPPEATKTSENCLS 226
Query: 266 PEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVV 325
P P+ +FVQ FQAQYRSSLTCPHC KQSNTFDPFLC+SLPIPL TR L VT+V
Sbjct: 227 PSA-QLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTRFLSVTLV 285
Query: 326 YQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIPTDQIVLTEMYYDGFHRSFCDTDDLE 385
+ K +R+G+AVP+ TVA LR+ V+ E +P D+++L E+Y GF RSF D +DL
Sbjct: 286 FPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVILVELYPSGFQRSFFDEEDLN 345
Query: 386 TVHESDCIFAFETPEIFRPEGILSQRGIHLNNNLNHLKFGLDYHRLSSPTQTAAKQGKMD 445
T+ E D ++AF+ P +G LS + LS+ + AA++G+
Sbjct: 346 TIAEGDNVYAFQVPP-SPSQGTLSAHPL----------------GLSASPRLAAREGQRF 388
Query: 446 SPTSRAGSDKIVLLVCNRACTGQQGKRFGLPFVLHLEKTIAWDLLQKEILEKMKYFLRPT 505
S S K+++L CN +GQQ RFG PF++ ++ ++W LQ+ IL K+++ ++
Sbjct: 389 S-LSLHSESKVLILFCNLVGSGQQASRFGPPFLIREDRAVSWAQLQQSILSKVRHLMKSE 447
Query: 506 VCIQVCP--FSLRVVSV-VGITYLLPQEEQPLCHPIVERALKSCGPGGTAHVKLVVEWDK 562
+Q FS+RVV + V +YL P++ +PLCH V+R L PGG HVKL VEWD
Sbjct: 448 APVQNLGSLFSIRVVGLSVACSYLSPKDSRPLCHWAVDRVLHLRRPGGPPHVKLAVEWDS 507
Query: 563 ETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDDAWRCPHC 622
++ LF + ++E DA+SV Q+++ HQ +CTL +CFQ YTKEE+LA DDAW+CPHC
Sbjct: 508 SVKERLFGSLQEERAQDADSV-WQQQQAHQQHSCTLDECFQFYTKEEQLAQDDAWKCPHC 566
Query: 623 KQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHVVKRSQSS 682
+ LQQG + LSLWTLPD+LIIHLKRF Q G+RR KL +VKFPL+GL+M PHV +RS S
Sbjct: 567 QVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVAQRSTSP 626
Query: 683 WSLPSHWSPWRRPYGLGRD-PEDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGLWYCFDD 741
+ W W++P L P D++YDLYAVCNHHG +QGGHYTAYC+NS+DG WY +DD
Sbjct: 627 EAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQWYSYDD 686
Query: 742 SDVQQLSEDEVCTQTAYILFYQRRTAIPSWSANSSVAGSTSSSLCEHWVSRL---PGSKP 798
S V+ L EDEV T+ AYILFYQ+R +IP WSA+SS+ GSTSSSL +HW+ RL GS
Sbjct: 687 STVEPLREDEVNTRGAYILFYQKRNSIPPWSASSSMRGSTSSSLSDHWLLRLGSHAGSTR 746
Query: 799 ASVTSAASSRRTSLASLSESVEMTGER-SEDDGGFSTRPFVRSVQRQSLSSRSSVTS 854
S+ S +S+ SL + +S T +++ GG R VR V+ +S+S ++ TS
Sbjct: 747 GSLLSWSSAPCPSLPQVPDSPIFTNSLCNQEKGGLEPRRLVRGVKGRSISMKAPTTS 803
Score = 36.2 bits (82), Expect = 0.22
Identities = 79/342 (23%), Positives = 130/342 (38%), Gaps = 44/342 (12%)
Query: 1014 SLAKKPES---TTKRSPSSKGTSEPEKSLR--KGRP-ALASQESSLSSTSPSSPLPVKVS 1067
SL + P+S T KG EP + +R KGR ++ + +S + P +P++ S
Sbjct: 759 SLPQVPDSPIFTNSLCNQEKGGLEPRRLVRGVKGRSISMKAPTTSRAKQGPFKTMPLRWS 818
Query: 1068 LKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASS 1127
S+ + S S P + +S ++ + + +KSAS + A
Sbjct: 819 FG-SKEKPPGASVELVEYLESRRRP----RSTSQSIVSLLTGTAGEDEKSASPRSNVALP 873
Query: 1128 TSAKKASGPATRSPFP-PGKSRTSDHSLSREGS---------RQSLGSD-----RASATS 1172
+++ R P P S +H L+ S +++ G D +
Sbjct: 874 ANSEDGGRAIERGPAGVPCPSAQPNHCLAPGNSDGPNTARKLKENAGQDIKLPRKFDLPL 933
Query: 1173 TSKPNSPRVSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKG------- 1225
T P+ AR EG+ A S M S SP + G +SK +G
Sbjct: 934 TVMPSVEHEKPARP-EGQKAMNWKESFQMGSKSSPPSPYM-GFSGNSKDSRRGTSELDRP 991
Query: 1226 ----LSFFKSALRQKETRRSTDLGKTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQ 1281
L+ +S R+KE RR+ + A +S + S+ S + D G PPA +
Sbjct: 992 LQGTLTLLRSVFRKKENRRN----ERAEVSPQVPPVSLVSGGLSPAMDGQAPG-SPPALR 1046
Query: 1282 QPNANTTGKEQLVTKDPASAKHSLLSARKSKSSQLDSGVPSS 1323
P G + +D SA SL RK+ + S + S
Sbjct: 1047 IPEGLARGLGSRLERDVWSAPSSLRLPRKASRAPRGSALGMS 1088
>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
Length = 963
Score = 165 bits (417), Expect = 3e-40
Identities = 92/233 (39%), Positives = 125/233 (53%), Gaps = 28/233 (12%)
Query: 556 LVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDD 615
L ++WD ETR + E E + V + + + + T L C +L+T E L D
Sbjct: 738 LAMDWDSETRRLYYDEQESEAYE--KHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHD 795
Query: 616 AWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHV 675
W CP+CK+ QQ + LW+LP +L++HLKRF R KL +V+FP+ GL+M+ V
Sbjct: 796 PWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFV 855
Query: 676 VKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGL 735
S RPY +YDL AV NH+G M GHYTAY KN ++G
Sbjct: 856 CNLSA-------------RPY---------VYDLIAVSNHYGAMGVGHYTAYAKNKLNGK 893
Query: 736 WYCFDDSDVQQLSEDEVCTQTAYILFYQRRT----AIPSWSANSSVAGSTSSS 784
WY FDDS+V SED++ T+ AY+LFYQRR PS S++ S G T S
Sbjct: 894 WYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPS 946
Score = 152 bits (384), Expect = 2e-36
Identities = 114/366 (31%), Positives = 167/366 (45%), Gaps = 44/366 (12%)
Query: 43 ASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGLRSCFPPGPAAAP 102
++ P+ + S SSA S + ++ + S + RGG G +A+
Sbjct: 234 STAPSRNFTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGG------SGFSASY 287
Query: 103 TPPPCPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYR 162
C PP+S P G+ GL N GNTCFMN+ LQCLSNT +Y +Y
Sbjct: 288 N---CQEPPSSHIQP--------GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYE 336
Query: 163 AGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYR 222
A + + P G +GE+ E A L++ +W+ R FKT V + A Q+
Sbjct: 337 A-----EINRDNPLGM----KGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFS 387
Query: 223 GNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMMPEGPSFPVC-------- 274
G Q D+QE L +LLD +HEDLN K KP E P V
Sbjct: 388 GYQQQDSQELLAFLLDGLHEDLNRVKK-------KPYLELKDANGRPDAVVAKEAWENHR 440
Query: 275 ---STFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCS 331
+ + + F ++S+L CP C K S TFDPF ++LP+PL R + V +V
Sbjct: 441 LRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHC 500
Query: 332 HCMRIGVAVPLSGTVARLREAVSMETKIPTDQIVLTEMYYDGFHRSFCDTDDLETVHESD 391
+ V VPL G V+ L EA+S + I + +V+ ++Y FH+ F + L + D
Sbjct: 501 RPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRD 560
Query: 392 CIFAFE 397
IF +E
Sbjct: 561 DIFVYE 566
>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
Length = 916
Score = 165 bits (417), Expect = 3e-40
Identities = 92/233 (39%), Positives = 125/233 (53%), Gaps = 28/233 (12%)
Query: 556 LVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDD 615
L ++WD ETR + E E + V + + + + T L C +L+T E L D
Sbjct: 691 LAMDWDSETRRLYYDEQESEAYE--KHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHD 748
Query: 616 AWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHV 675
W CP+CK+ QQ + LW+LP +L++HLKRF R KL +V+FP+ GL+M+ V
Sbjct: 749 PWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFV 808
Query: 676 VKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGL 735
S RPY +YDL AV NH+G M GHYTAY KN ++G
Sbjct: 809 CNLSA-------------RPY---------VYDLIAVSNHYGAMGVGHYTAYAKNKLNGK 846
Query: 736 WYCFDDSDVQQLSEDEVCTQTAYILFYQRRT----AIPSWSANSSVAGSTSSS 784
WY FDDS+V SED++ T+ AY+LFYQRR PS S++ S G T S
Sbjct: 847 WYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPS 899
Score = 150 bits (379), Expect = 8e-36
Identities = 102/302 (33%), Positives = 144/302 (47%), Gaps = 35/302 (11%)
Query: 107 CPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRP 166
C PP+S P G+ GL N GNTCFMN+ LQCLSNT +Y +Y A
Sbjct: 242 CQEPPSSHIQP--------GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEA--- 290
Query: 167 EPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQ 226
+ + P G +GE+ E A L++ +W+ R FKT V + A Q+ G Q
Sbjct: 291 --EINRDNPLGM----KGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQ 344
Query: 227 HDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMMPEGPSFPVC-----------S 275
D+QE L +LLD +HEDLN K KP E P V
Sbjct: 345 QDSQELLAFLLDGLHEDLNRVKK-------KPYLELKDANGRPDAVVAKEAWENHRLRND 397
Query: 276 TFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMR 335
+ + + F ++S+L CP C K S TFDPF ++LP+PL R + V +V +
Sbjct: 398 SVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQ 457
Query: 336 IGVAVPLSGTVARLREAVSMETKIPTDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFA 395
V VPL G V+ L EA+S + I + +V+ ++Y FH+ F + L + D IF
Sbjct: 458 YRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFV 517
Query: 396 FE 397
+E
Sbjct: 518 YE 519
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 161 bits (408), Expect = 3e-39
Identities = 96/281 (34%), Positives = 148/281 (52%), Gaps = 21/281 (7%)
Query: 125 PGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQG 184
PG+ GL N GNTCFMN+ +QCLSNT EY +Y + + + P G +G
Sbjct: 257 PGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKY-----QEELNFDNPLGM----RG 307
Query: 185 EVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDL 244
E+ + A L++ +W+ +++ R FKT V + A Q+ G Q D QE L +LLD +HEDL
Sbjct: 308 EIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDL 367
Query: 245 NHSVKQSGQPPLKPPSETDMMPEGPSFPVC--------STFVQELFQAQYRSSLTCPHCQ 296
N K+ P + D P+ + + ++F ++S+L CP C
Sbjct: 368 NRIRKK----PYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECA 423
Query: 297 KQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSME 356
K S TFDPF ++LP+P+ R L V +V + M+ V VP G + L A+S
Sbjct: 424 KISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSAL 483
Query: 357 TKIPTDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFE 397
+ IP D++++T++Y FHR F ++L ++ E D I+ FE
Sbjct: 484 SGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFE 524
Score = 150 bits (378), Expect = 1e-35
Identities = 80/210 (38%), Positives = 112/210 (53%), Gaps = 25/210 (11%)
Query: 556 LVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDD 615
L ++WD + + F E ESV + + L C +L+T +E+L +D
Sbjct: 720 LALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKK---PFVKLKDCIELFTTKEKLGAED 776
Query: 616 AWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHV 675
W CP+CK+ QQ + L LW+LP VL++HLKRF R KL +V FP+ LDM+ +
Sbjct: 777 PWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFL 836
Query: 676 VKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGL 735
+ + P R Y+L AV NH+G M GGHYTA+ KN DG
Sbjct: 837 INPNA---------GPCR-------------YNLIAVSNHYGGMGGGHYTAFAKNKDDGK 874
Query: 736 WYCFDDSDVQQLSEDEVCTQTAYILFYQRR 765
WY FDDS V SED++ ++ AY+LFYQR+
Sbjct: 875 WYYFDDSSVSTASEDQIVSKAAYVLFYQRQ 904
>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
Length = 1318
Score = 149 bits (376), Expect = 2e-35
Identities = 120/383 (31%), Positives = 171/383 (44%), Gaps = 52/383 (13%)
Query: 36 GGAGGPGASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGLRSCFP 95
GGA P A + S ARS + + V T + + H++ +
Sbjct: 410 GGAPHPLTGQEEARAVEKDKSKARSEDTGLDSVA-TRTPMEHVTPK-------------- 454
Query: 96 PGPAAAPTPPPC--PPPPASPAPPACAAEP--------VPGVAGLRNHGNTCFMNATLQC 145
P A P C PP P SP E +PG GL N GNTCFMN+ +Q
Sbjct: 455 PETHLASPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQS 514
Query: 146 LSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQ 205
LSNT ++ + A + P G G G + A L+RALW +
Sbjct: 515 LSNTRELRDFFHDRSFEA-----EINYNNPLGTG----GRLAIGFAVLLRALWKGTHHAF 565
Query: 206 HSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLN--------HSVKQSGQPPLK 257
K IV+ A Q+ G +QHDAQEF+ +LLD +HEDLN +V G+P
Sbjct: 566 QPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEV 625
Query: 258 PPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHT 317
E + + +F+ +LFQ QY+S L CP C K S TFDPFL LP+PLP
Sbjct: 626 VAEEAWQRHKMRN----DSFIVDLFQGQYKSKLVCPVCAKVSITFDPFL--YLPVPLPQK 679
Query: 318 RPLYVTVVYQGKCSHCMRIGVAVPLS---GTVARLREAVSMETKIPTDQIVLTEMYYDGF 374
+ + + V Y + H I V +S T + + +++S + + + L E+ + F
Sbjct: 680 QKV-LPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRF 738
Query: 375 HRSFCDTDDLETVHESDCIFAFE 397
HR F + L+TV SD + FE
Sbjct: 739 HRVFLPSHSLDTVSPSDTLLCFE 761
Score = 129 bits (325), Expect = 1e-29
Identities = 95/276 (34%), Positives = 130/276 (47%), Gaps = 52/276 (18%)
Query: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFR-QEGDRR 655
TL QC L+T+ E LAP++AW CP CKQ ++ S L LW LP+VLI+ LKRF + R
Sbjct: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
Query: 656 MKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNH 715
K+ ++V+FP+ LD++ + Q LPS YDLYAV NH
Sbjct: 1119 DKINDLVEFPVRNLDLSKFCI--GQKEEQLPS-------------------YDLYAVINH 1157
Query: 716 HGTMQGGHYTAYCK-------NSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRTAI 768
+G M GGHYTA + D W FDDS V + E +V T+ AY+LFY+RR
Sbjct: 1158 YGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRR--- 1214
Query: 769 PSWSANSSVAGSTSSSLCEHWVSRLPGSKPASVTSAASSRRTSLASLSESVEMTGERSED 828
NS V + EH P PA+ +A+ + R L E E S
Sbjct: 1215 -----NSPVERPPRAGHSEHH----PDLGPAAEAAASQASRI-WQELEAEEEPVPEGSGP 1264
Query: 829 DGGFSTRPFVRSVQRQSLSSRSSVTSPLAVNENCMR 864
G + + +V + R P +E C+R
Sbjct: 1265 LGPWGPQDWVGPLPR----------GPTTPDEGCLR 1290
>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
Length = 963
Score = 139 bits (351), Expect = 1e-32
Identities = 75/231 (32%), Positives = 118/231 (51%), Gaps = 22/231 (9%)
Query: 556 LVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDD 615
+ ++W+ E + + E E + V ++ L +C +L+T E L ++
Sbjct: 743 IAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKK----APVRLQECIELFTTVETLEKEN 798
Query: 616 AWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHV 675
W CP CKQ Q + L LW LP++LIIHLKRF R KL +V+FP+ LD + V
Sbjct: 799 PWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFV 858
Query: 676 VKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGL 735
++ S +PE Y YDL AV NH+G M+ GHYT + N G
Sbjct: 859 IQPQNES------------------NPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQ 900
Query: 736 WYCFDDSDVQQLSEDEVCTQTAYILFYQRRTAIPSWSANSSVAGSTSSSLC 786
W+ FDD+ V ++E+++ ++ AY+LFYQR+ + + +G+ +S C
Sbjct: 901 WHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLLSPAGSSGAPASPAC 951
Score = 134 bits (336), Expect = 8e-31
Identities = 88/282 (31%), Positives = 138/282 (48%), Gaps = 23/282 (8%)
Query: 125 PGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQG-Q 183
PG+ GL N GNTCFMN+ LQCLSN EY Y E+ R G +
Sbjct: 306 PGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYL----------EELNFRNPLGMK 355
Query: 184 GEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHED 243
GE+ E A LV+ W+ + FK V A Q+ G QHD+QE L +LLD +HED
Sbjct: 356 GEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHED 415
Query: 244 LNHSVKQ--------SGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHC 295
LN K+ +G+P + E + + + + + F ++S+L CP C
Sbjct: 416 LNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRN----DSVIVDTFHGLFKSTLVCPDC 471
Query: 296 QKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSM 355
S TFDPF +S+P+P+ H R L V + + + VP G ++ L A+S
Sbjct: 472 GNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSK 531
Query: 356 ETKIPTDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFE 397
T I +++++ +++ F++ + + L ++ + D IF +E
Sbjct: 532 HTGISPERMMVADVFSHRFYKLYQLEEPLSSILDRDDIFVYE 573
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 130 bits (327), Expect = 9e-30
Identities = 63/169 (37%), Positives = 95/169 (56%), Gaps = 26/169 (15%)
Query: 596 CTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRR 655
CTL C +L++KEE+L ++ + C HC+ + + +W LP VL++HLKRF +G +
Sbjct: 962 CTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWK 1021
Query: 656 MKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYI--YDLYAVC 713
KLQ V FPL LD++ +V+ P++ + Y+L++V
Sbjct: 1022 QKLQTSVDFPLENLDLSQYVI------------------------GPKNNLKKYNLFSVS 1057
Query: 714 NHHGTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFY 762
NH+G + GGHYTAYCKN+ W+ FDD +V +S V + AYILFY
Sbjct: 1058 NHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106
Score = 109 bits (273), Expect = 2e-23
Identities = 66/192 (34%), Positives = 101/192 (52%), Gaps = 13/192 (6%)
Query: 125 PGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQG 184
P + GLRN GNTC+MN+ LQCL N A+Y Y+ D + G +G
Sbjct: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQ-------DDINRSNLLGHKG-- 824
Query: 185 EVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDL 244
EV E+ +++ALWT +Y +DFK + K Q+ G SQ D+QE LL+L+D +HEDL
Sbjct: 825 EVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDL 884
Query: 245 NHSVKQSGQPPLKPPSETDMMPEGPSF----PVCSTFVQELFQAQYRSSLTCPHCQKQSN 300
N + + D ++ + + + LFQ Q++S++ C C K+S
Sbjct: 885 NKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSR 944
Query: 301 TFDPFLCISLPI 312
TF+ F+ +SLP+
Sbjct: 945 TFEAFMYLSLPL 956
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 130 bits (327), Expect = 9e-30
Identities = 63/169 (37%), Positives = 95/169 (56%), Gaps = 26/169 (15%)
Query: 596 CTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRR 655
CTL C +L++KEE+L ++ + C HC+ + + +W LP VL++HLKRF +G +
Sbjct: 962 CTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWK 1021
Query: 656 MKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYI--YDLYAVC 713
KLQ V FPL LD++ +V+ P++ + Y+L++V
Sbjct: 1022 QKLQTSVDFPLENLDLSQYVI------------------------GPKNNLKKYNLFSVS 1057
Query: 714 NHHGTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFY 762
NH+G + GGHYTAYCKN+ W+ FDD +V +S V + AYILFY
Sbjct: 1058 NHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106
Score = 109 bits (273), Expect = 2e-23
Identities = 66/192 (34%), Positives = 101/192 (52%), Gaps = 13/192 (6%)
Query: 125 PGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQG 184
P + GLRN GNTC+MN+ LQCL N A+Y Y+ D + G +G
Sbjct: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQ-------DDINRSNLLGHKG-- 824
Query: 185 EVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDL 244
EV E+ +++ALWT +Y +DFK + K Q+ G SQ D+QE LL+L+D +HEDL
Sbjct: 825 EVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDL 884
Query: 245 NHSVKQSGQPPLKPPSETDMMPEGPSF----PVCSTFVQELFQAQYRSSLTCPHCQKQSN 300
N + + D ++ + + + LFQ Q++S++ C C K+S
Sbjct: 885 NKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSR 944
Query: 301 TFDPFLCISLPI 312
TF+ F+ +SLP+
Sbjct: 945 TFEAFMYLSLPL 956
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 130 bits (327), Expect = 9e-30
Identities = 63/169 (37%), Positives = 95/169 (56%), Gaps = 26/169 (15%)
Query: 596 CTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRR 655
CTL C +L++KEE+L ++ + C HC+ + + +W LP VL++HLKRF +G +
Sbjct: 962 CTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWK 1021
Query: 656 MKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYI--YDLYAVC 713
KLQ V FPL LD++ +V+ P++ + Y+L++V
Sbjct: 1022 QKLQTSVDFPLENLDLSQYVI------------------------GPKNNLKKYNLFSVS 1057
Query: 714 NHHGTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFY 762
NH+G + GGHYTAYCKN+ W+ FDD +V +S V + AYILFY
Sbjct: 1058 NHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106
Score = 109 bits (273), Expect = 2e-23
Identities = 66/192 (34%), Positives = 101/192 (52%), Gaps = 13/192 (6%)
Query: 125 PGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQG 184
P + GLRN GNTC+MN+ LQCL N A+Y Y+ D + G +G
Sbjct: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQ-------DDINRSNLLGHKG-- 824
Query: 185 EVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDL 244
EV E+ +++ALWT +Y +DFK + K Q+ G SQ D+QE LL+L+D +HEDL
Sbjct: 825 EVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDL 884
Query: 245 NHSVKQSGQPPLKPPSETDMMPEGPSF----PVCSTFVQELFQAQYRSSLTCPHCQKQSN 300
N + + D ++ + + + LFQ Q++S++ C C K+S
Sbjct: 885 NKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSR 944
Query: 301 TFDPFLCISLPI 312
TF+ F+ +SLP+
Sbjct: 945 TFEAFMYLSLPL 956
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 118 bits (295), Expect = 4e-26
Identities = 67/198 (33%), Positives = 97/198 (48%), Gaps = 23/198 (11%)
Query: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRM 656
TL C + + L D+ + C CK+L+ G + P++L IHLKRFR E
Sbjct: 560 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFST 619
Query: 657 KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHH 716
K+ V FPL GLD+ P + K S + + YDL +V HH
Sbjct: 620 KISTHVSFPLEGLDLQPFLAKDSPA---------------------QIVTYDLLSVICHH 658
Query: 717 GTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRT--AIPSWSAN 774
GT GHY AYC+N+++ LWY FDD V ++SE V AY+LFY++ + A
Sbjct: 659 GTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRI 718
Query: 775 SSVAGSTSSSLCEHWVSR 792
S++ SL + ++SR
Sbjct: 719 SNLLNIMEPSLLQFYISR 736
Score = 56.6 bits (135), Expect = 2e-07
Identities = 44/147 (29%), Positives = 62/147 (42%), Gaps = 30/147 (20%)
Query: 126 GVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGE 185
G+ GL+N GNTC+MNA LQ LSN ++ L R + P
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFF-LDCGGLARTDKKP--------------A 227
Query: 186 VTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQ--------YRGNSQHDAQEFLLWLL 237
+ + L+ LW H ++V Q +RG SQ DAQEFL L+
Sbjct: 228 ICKSYLKLMTELW-------HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLM 280
Query: 238 DRVHEDLNHSVKQSGQPPLKPPSETDM 264
D +HE+L V + + P +E M
Sbjct: 281 DLLHEELKEQVMEVEEDPQTITTEETM 307
>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
Length = 942
Score = 118 bits (295), Expect = 4e-26
Identities = 67/198 (33%), Positives = 97/198 (48%), Gaps = 23/198 (11%)
Query: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRM 656
TL C + + L D+ + C CK+L+ G + P++L IHLKRFR E
Sbjct: 568 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFST 627
Query: 657 KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHH 716
K+ V FPL GLD+ P + K S + + YDL +V HH
Sbjct: 628 KISTHVSFPLEGLDLQPFLAKDSPA---------------------QIVTYDLLSVICHH 666
Query: 717 GTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRT--AIPSWSAN 774
GT GHY AYC+N+++ LWY FDD V ++SE V AY+LFY++ + A
Sbjct: 667 GTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRI 726
Query: 775 SSVAGSTSSSLCEHWVSR 792
S++ SL + ++SR
Sbjct: 727 SNLLNIMEPSLLQFYISR 744
Score = 56.6 bits (135), Expect = 2e-07
Identities = 44/147 (29%), Positives = 62/147 (42%), Gaps = 30/147 (20%)
Query: 126 GVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGE 185
G+ GL+N GNTC+MNA LQ LSN ++ L R + P
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFF-LDCGGLARTDKKP--------------A 227
Query: 186 VTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQ--------YRGNSQHDAQEFLLWLL 237
+ + L+ LW H ++V Q +RG SQ DAQEFL L+
Sbjct: 228 ICKSYLKLMTELW-------HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLM 280
Query: 238 DRVHEDLNHSVKQSGQPPLKPPSETDM 264
D +HE+L V + + P +E M
Sbjct: 281 DLLHEELKEQVMEVEEDPQTITTEETM 307
>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
Length = 911
Score = 118 bits (295), Expect = 4e-26
Identities = 67/198 (33%), Positives = 97/198 (48%), Gaps = 23/198 (11%)
Query: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRM 656
TL C + + L D+ + C CK+L+ G + P++L IHLKRFR E
Sbjct: 537 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFST 596
Query: 657 KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHH 716
K+ V FPL GLD+ P + K S + + YDL +V HH
Sbjct: 597 KISTHVSFPLEGLDLQPFLAKDSPA---------------------QIVTYDLLSVICHH 635
Query: 717 GTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRT--AIPSWSAN 774
GT GHY AYC+N+++ LWY FDD V ++SE V AY+LFY++ + A
Sbjct: 636 GTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRI 695
Query: 775 SSVAGSTSSSLCEHWVSR 792
S++ SL + ++SR
Sbjct: 696 SNLLNIMEPSLLQFYISR 713
Score = 56.6 bits (135), Expect = 2e-07
Identities = 44/147 (29%), Positives = 62/147 (42%), Gaps = 30/147 (20%)
Query: 126 GVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGE 185
G+ GL+N GNTC+MNA LQ LSN ++ L R + P
Sbjct: 152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFF-LDCGGLARTDKKP--------------A 196
Query: 186 VTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQ--------YRGNSQHDAQEFLLWLL 237
+ + L+ LW H ++V Q +RG SQ DAQEFL L+
Sbjct: 197 ICKSYLKLMTELW-------HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLM 249
Query: 238 DRVHEDLNHSVKQSGQPPLKPPSETDM 264
D +HE+L V + + P +E M
Sbjct: 250 DLLHEELKEQVMEVEEDPQTITTEETM 276
>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 116 bits (290), Expect = 2e-25
Identities = 68/198 (34%), Positives = 95/198 (47%), Gaps = 23/198 (11%)
Query: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRM 656
TL C + + L D+ + C CK+L+ G + LP++L IHLKRFR E
Sbjct: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSF 597
Query: 657 KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHH 716
K+ + V FPL GLD+ P + K S + YDL +V HH
Sbjct: 598 KINSHVSFPLEGLDLRPFLAKECTSQITT---------------------YDLLSVICHH 636
Query: 717 GTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRT--AIPSWSAN 774
GT GHY AYC+N ++G WY FDD V ++ E V Y+LFY++ + A+
Sbjct: 637 GTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQV 696
Query: 775 SSVAGSTSSSLCEHWVSR 792
S+A SL +VSR
Sbjct: 697 VSLAAMREPSLLRFYVSR 714
Score = 54.3 bits (129), Expect = 8e-07
Identities = 53/185 (28%), Positives = 81/185 (43%), Gaps = 33/185 (17%)
Query: 103 TPPPCPPPPASPAPPACAAEPVP--------GVAGLRNHGNTCFMNATLQCLSN----TE 150
+PPP P A P A E G+ G++N GN+C+MNA LQ LSN T+
Sbjct: 112 SPPPSHPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQ 171
Query: 151 LFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQHSRDF 210
F E L + ++PA + ++ ++ H R + + + H
Sbjct: 172 FFLECGGLVR----------TDKKPA--LCKSYQKLVSEVWHKKRPSYVVPTSLSHG--- 216
Query: 211 KTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQS---GQPPLKPPSETDMMPE 267
I N + +RG +Q D QEFL L+D++HE+L V + + S+TD E
Sbjct: 217 --IKLVNPM-FRGYAQQDTQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKRE 273
Query: 268 GPSFP 272
G P
Sbjct: 274 GDRSP 278
>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 116 bits (290), Expect = 2e-25
Identities = 68/198 (34%), Positives = 95/198 (47%), Gaps = 23/198 (11%)
Query: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRM 656
TL C + + L D+ + C CK+L+ G + LP++L IHLKRFR E
Sbjct: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSF 597
Query: 657 KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHH 716
K+ + V FPL GLD+ P + K S + YDL +V HH
Sbjct: 598 KINSHVSFPLEGLDLRPFLAKECTSQITT---------------------YDLLSVICHH 636
Query: 717 GTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRT--AIPSWSAN 774
GT GHY AYC+N ++G WY FDD V ++ E V Y+LFY++ + A+
Sbjct: 637 GTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQV 696
Query: 775 SSVAGSTSSSLCEHWVSR 792
S+A SL +VSR
Sbjct: 697 VSLAAMREPSLLRFYVSR 714
Score = 54.3 bits (129), Expect = 8e-07
Identities = 53/185 (28%), Positives = 81/185 (43%), Gaps = 33/185 (17%)
Query: 103 TPPPCPPPPASPAPPACAAEPVP--------GVAGLRNHGNTCFMNATLQCLSN----TE 150
+PPP P A P A E G+ G++N GN+C+MNA LQ LSN T+
Sbjct: 112 SPPPSHPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQ 171
Query: 151 LFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQHSRDF 210
F E L + ++PA + ++ ++ H R + + + H
Sbjct: 172 FFLECGGLVR----------TDKKPA--LCKSYQKLVSEVWHKKRPSYVVPTSLSHG--- 216
Query: 211 KTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQS---GQPPLKPPSETDMMPE 267
I N + +RG +Q D QEFL L+D++HE+L V + + S+TD E
Sbjct: 217 --IKLVNPM-FRGYAQQDTQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKRE 273
Query: 268 GPSFP 272
G P
Sbjct: 274 GDRSP 278
>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 116 bits (290), Expect = 2e-25
Identities = 68/198 (34%), Positives = 95/198 (47%), Gaps = 23/198 (11%)
Query: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRM 656
TL C + + L D+ + C CK+L+ G + LP++L IHLKRFR E
Sbjct: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSF 597
Query: 657 KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHH 716
K+ + V FPL GLD+ P + K S + YDL +V HH
Sbjct: 598 KINSHVSFPLEGLDLRPFLAKECTSQITT---------------------YDLLSVICHH 636
Query: 717 GTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRT--AIPSWSAN 774
GT GHY AYC+N ++G WY FDD V ++ E V Y+LFY++ + A+
Sbjct: 637 GTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQV 696
Query: 775 SSVAGSTSSSLCEHWVSR 792
S+A SL +VSR
Sbjct: 697 VSLAAMREPSLLRFYVSR 714
Score = 54.3 bits (129), Expect = 8e-07
Identities = 53/185 (28%), Positives = 81/185 (43%), Gaps = 33/185 (17%)
Query: 103 TPPPCPPPPASPAPPACAAEPVP--------GVAGLRNHGNTCFMNATLQCLSN----TE 150
+PPP P A P A E G+ G++N GN+C+MNA LQ LSN T+
Sbjct: 112 SPPPSHPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQ 171
Query: 151 LFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQHSRDF 210
F E L + ++PA + ++ ++ H R + + + H
Sbjct: 172 FFLECGGLVR----------TDKKPA--LCKSYQKLVSEVWHKKRPSYVVPTSLSHG--- 216
Query: 211 KTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQS---GQPPLKPPSETDMMPE 267
I N + +RG +Q D QEFL L+D++HE+L V + + S+TD E
Sbjct: 217 --IKLVNPM-FRGYAQQDTQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKRE 273
Query: 268 GPSFP 272
G P
Sbjct: 274 GDRSP 278
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 111 bits (278), Expect = 4e-24
Identities = 59/167 (35%), Positives = 85/167 (50%), Gaps = 23/167 (13%)
Query: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRM 656
TL C +L+TKE+ L D+ C C+ ++ S+ P +L++HLKRF + R
Sbjct: 245 TLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTS 304
Query: 657 KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHH 716
KL V FPL LD+ + + + +Y+LYAV NH
Sbjct: 305 KLTTFVNFPLRDLDLREFASENTNHA-----------------------VYNLYAVSNHS 341
Query: 717 GTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQ 763
GT GGHYTAYC++ G W+ F+DS V +S +V T AY+LFY+
Sbjct: 342 GTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 388
Score = 107 bits (268), Expect = 6e-23
Identities = 79/242 (32%), Positives = 110/242 (45%), Gaps = 39/242 (16%)
Query: 95 PPGPAAAPTPPPC----PPPPASPA-----------PPACAAEPVPGVAGLRNHGNTCFM 139
P P AAP P P P SP+ A ++ G+AGLRN GNTCFM
Sbjct: 10 PEDPPAAPFPALAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFM 69
Query: 140 NATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWT 199
N+ LQCLSNT +Y Y + G+ + E+ A L++ +WT
Sbjct: 70 NSILQCLSNTRELRDYCLQRLYM-----------RDLHHGSNAHTALVEEFAKLIQTIWT 118
Query: 200 LEYTPQHS-RDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKP 258
S +FKT + + A ++ G +Q DAQEFL +LLD +H ++N + P
Sbjct: 119 SSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLR----PKSN 174
Query: 259 PSETDMMPEGPS--------FPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISL 310
P D +P+ + + +LF Q +SSLTC C S FDPF +SL
Sbjct: 175 PENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSL 234
Query: 311 PI 312
PI
Sbjct: 235 PI 236
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 111 bits (278), Expect = 4e-24
Identities = 59/167 (35%), Positives = 85/167 (50%), Gaps = 23/167 (13%)
Query: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRM 656
TL C +L+TKE+ L D+ C C+ ++ S+ P +L++HLKRF + R
Sbjct: 454 TLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTS 513
Query: 657 KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHH 716
KL V FPL LD+ + + + +Y+LYAV NH
Sbjct: 514 KLTTFVNFPLRDLDLREFASENTNHA-----------------------VYNLYAVSNHS 550
Query: 717 GTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQ 763
GT GGHYTAYC++ G W+ F+DS V +S +V T AY+LFY+
Sbjct: 551 GTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 597
Score = 109 bits (273), Expect = 2e-23
Identities = 72/216 (33%), Positives = 103/216 (47%), Gaps = 24/216 (11%)
Query: 106 PCPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGR 165
P P +SP ++ G+AGLRN GNTCFMN+ LQCLSNT +Y Y
Sbjct: 245 PGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYM--- 301
Query: 166 PEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQHS-RDFKTIVSKNALQYRGN 224
+ G+ + E+ A L++ +WT S +FKT + + A ++ G
Sbjct: 302 --------RDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGY 353
Query: 225 SQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMMPEGPS--------FPVCST 276
+Q DAQEFL +LLD +H ++N + P P D +P+ +
Sbjct: 354 NQQDAQEFLRFLLDGLHNEVNRVTLR----PKSNPENLDHLPDDEKGRQMWRKYLEREDS 409
Query: 277 FVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPI 312
+ +LF Q +SSLTC C S FDPF +SLPI
Sbjct: 410 RIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI 445
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 103 bits (258), Expect = 9e-22
Identities = 60/199 (30%), Positives = 97/199 (48%), Gaps = 21/199 (10%)
Query: 572 TEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSIT 631
T D P+ + R+ H P +L+ C Q +T+ E L +C C+ Q+ +
Sbjct: 524 TFDSQNPERADSTVSRD-DHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQ 582
Query: 632 LSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSP 691
L++ LP V HLKRF G +R K+ + FPL LDMTP + +S
Sbjct: 583 LTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLE-LDMTPFLASTKESRMK------- 634
Query: 692 WRRPYGLGRDPEDYI-----YDLYAVCNHHGTMQGGHYTAYCKNSVDGLWYCFDDSDVQQ 746
G+ P D + Y L+AV NHHGT++ GHYT++ + D W+ DD+ + +
Sbjct: 635 ------EGQPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIRQQKD-QWFSCDDAIITK 687
Query: 747 LSEDEVCTQTAYILFYQRR 765
+ +++ Y+LFY ++
Sbjct: 688 ATIEDLLYSEGYLLFYHKQ 706
Score = 68.9 bits (167), Expect = 3e-11
Identities = 50/188 (26%), Positives = 80/188 (42%), Gaps = 29/188 (15%)
Query: 126 GVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGE 185
G+ GL N GNTCFMN +Q L++ L ++ +++ PS
Sbjct: 361 GLRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLC-------------- 406
Query: 186 VTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLN 245
+ +++ L A+++ TP ++ +A G Q DA EFL+ +LD +H
Sbjct: 407 LVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLH---R 463
Query: 246 HSVKQSGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPF 305
HS SG P+ C+ + ++F +S +TC C S T DP
Sbjct: 464 HSKDDSGGQEANNPN------------CCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPC 511
Query: 306 LCISLPIP 313
ISL +P
Sbjct: 512 WDISLDLP 519
Score = 38.5 bits (88), Expect = 0.044
Identities = 15/24 (62%), Positives = 16/24 (66%)
Query: 95 PPGPAAAPTPPPCPPPPASPAPPA 118
PP P A P PPP PPPP +P P A
Sbjct: 123 PPPPPARPPPPPPPPPPPAPRPRA 146
Score = 37.4 bits (85), Expect = 0.098
Identities = 22/58 (37%), Positives = 26/58 (44%), Gaps = 7/58 (12%)
Query: 67 RVLKTLSTLSHLSSEGAAPDRGG-------LRSCFPPGPAAAPTPPPCPPPPASPAPP 117
+VL ++ H SS P R RS PG +A P PP PPPP P PP
Sbjct: 82 KVLPSIPLRCHSSSSPVCPRRKPRPRPQPRARSRSQPGLSAPPPPPARPPPPPPPPPP 139
>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
Length = 1604
Score = 103 bits (258), Expect = 9e-22
Identities = 81/287 (28%), Positives = 131/287 (45%), Gaps = 33/287 (11%)
Query: 126 GVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQ--YRAGRPEPSPDPEQPAGRGAQGQ 183
G GL N GNTCFMN+++QC+SNT+ +Y G+ Y R P +
Sbjct: 732 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNP-----------IGMK 780
Query: 184 GEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHED 243
G + + LV+ LW+ + ++K A ++ G Q D+QE L +LLD +HED
Sbjct: 781 GHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHED 840
Query: 244 LNHSVKQSGQPPLKPPSETDMMPEGPSFPVCS-----------TFVQELFQAQYRSSLTC 292
LN + KP E P + V + + V +LF Q RS + C
Sbjct: 841 LNRVHE-------KPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKC 893
Query: 293 PHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREA 352
C S FDPF +SLP+P+ L +TV+ + +R G+ + + L++
Sbjct: 894 KTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLDGTTP-VRYGLRLNMDEKYTGLKKQ 952
Query: 353 VSMETKIPTDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETP 399
+S + ++QI+L E++ ++F + + S + AFE P
Sbjct: 953 LSDLCGLNSEQILLAEVHGSNI-KNFPQDNQKVRLSVSGFLCAFEIP 998
Score = 77.4 bits (189), Expect = 9e-14
Identities = 40/123 (32%), Positives = 63/123 (51%), Gaps = 2/123 (1%)
Query: 556 LVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDD 615
+ V+WD + +++ + + ESV ++ R Q + L C + +T EE L ++
Sbjct: 1195 IAVDWDPTALHLRYQTSQERVVDEHESV--EQSRRAQAEPINLDSCLRAFTSEEELGENE 1252
Query: 616 AWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHV 675
+ C CK + L LW LP +LIIHLKRF+ R +K Q +VKFP D + +
Sbjct: 1253 MYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAFL 1312
Query: 676 VKR 678
V R
Sbjct: 1313 VPR 1315
Score = 67.8 bits (164), Expect = 7e-11
Identities = 29/60 (48%), Positives = 42/60 (70%), Gaps = 1/60 (1%)
Query: 706 IYDLYAVCNHHGTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRR 765
IY+LYA+ H G + GGHY Y KN + WYC++DS ++L DE+ T +AYILFY+++
Sbjct: 1509 IYNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQ 1567
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 103 bits (256), Expect = 1e-21
Identities = 80/287 (27%), Positives = 131/287 (45%), Gaps = 33/287 (11%)
Query: 126 GVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQ--YRAGRPEPSPDPEQPAGRGAQGQ 183
G GL N GNTCFMN+++QC+SNT+ +Y G+ Y R P +
Sbjct: 530 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNP-----------IGMK 578
Query: 184 GEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHED 243
G + + LV+ LW+ + ++K A ++ G Q D+QE L +LLD +HED
Sbjct: 579 GHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHED 638
Query: 244 LNHSVKQSGQPPLKPPSETDMMPEGPSFPVCS-----------TFVQELFQAQYRSSLTC 292
LN + KP E P + V + + + +LF Q RS + C
Sbjct: 639 LNRVHE-------KPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKC 691
Query: 293 PHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREA 352
C S FDPF +SLP+P+ L +TV+ + +R G+ + + L++
Sbjct: 692 KTCGHISVRFDPFNFLSLPLPMDSYMDLEITVIKLDGTTP-VRYGLRLNMDEKYTGLKKQ 750
Query: 353 VSMETKIPTDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETP 399
+ + ++QI+L E+ +D ++F + + S + AFE P
Sbjct: 751 LRDLCGLNSEQILLAEV-HDSNIKNFPQDNQKVQLSVSGFLCAFEIP 796
Score = 68.6 bits (166), Expect = 4e-11
Identities = 29/60 (48%), Positives = 42/60 (70%), Gaps = 1/60 (1%)
Query: 706 IYDLYAVCNHHGTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRR 765
IY+LYA+ H G + GGHY Y KN + WYC++DS ++L DE+ T +AYILFY+++
Sbjct: 1311 IYNLYAISCHSGILSGGHYITYAKNP-NCKWYCYNDSSCEELHPDEIDTDSAYILFYEQQ 1369
Score = 67.8 bits (164), Expect = 7e-11
Identities = 37/123 (30%), Positives = 59/123 (47%), Gaps = 2/123 (1%)
Query: 556 LVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDD 615
+ V+W + +++ + ESV ++ R Q + L C + +T EE L +
Sbjct: 993 IAVDWHPTALHLRYQTSQERVVDKHESV--EQSRRAQAEPINLDSCLRAFTSEEELGESE 1050
Query: 616 AWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHV 675
+ C CK + L LW LP LIIHLKRF+ D+ +K Q +V+F D + +
Sbjct: 1051 MYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQWIKSQKIVRFLRESFDPSAFL 1110
Query: 676 VKR 678
V R
Sbjct: 1111 VPR 1113
Score = 32.3 bits (72), Expect = 3.2
Identities = 45/157 (28%), Positives = 64/157 (40%), Gaps = 15/157 (9%)
Query: 972 QGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSHPGSLAKKPESTTKRSPSS-- 1029
QGD L S P ++ VD S + K+PS SL+ S+ K SPSS
Sbjct: 1126 QGDEL---SKPRILAREVKKVDAQSSAGKEDMLLSKSPS---SLSANISSSPKGSPSSSR 1179
Query: 1030 -KGTSEPEKSLRKGRPALASQESSLSSTSPSSPLP-VKVSLKPSRSRSKADSS-SRGSGR 1086
GTS P S + P S +L + LP + KPS S+ D+S G+G+
Sbjct: 1180 KSGTSCP--SSKNSSP--NSSPRTLGRSKGRLRLPQIGSKNKPSSSKKNLDASKENGAGQ 1235
Query: 1087 HSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTY 1123
A A + SQ + +P + A+ Y
Sbjct: 1236 ICELADALSRGHMRGGSQPELVTPQDHEVALANGFLY 1272
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 101 bits (252), Expect = 4e-21
Identities = 65/192 (33%), Positives = 92/192 (47%), Gaps = 23/192 (11%)
Query: 577 IPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWT 636
IP + + + + P C+L C + +T E L + + C CK+ Q+ + +
Sbjct: 344 IPSQFRSKRSKNQENGP-VCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQK 402
Query: 637 LPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPY 696
LP VL +HLKRF R K+ V+FPL GLDM ++++ S
Sbjct: 403 LPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGLDMKCYLLEPENSG-------------- 448
Query: 697 GLGRDPEDYIYDLYAVCNHHGTMQG-GHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQ 755
PE +YDL AV HHG+ G GHYTAY + +G W+ F+DS V E+ V
Sbjct: 449 -----PESCLYDLAAVVVHHGSGVGSGHYTAYATH--EGRWFHFNDSTVTLTDEETVVKA 501
Query: 756 TAYILFYQRRTA 767
AYILFY A
Sbjct: 502 KAYILFYVEHQA 513
Score = 83.2 bits (204), Expect = 2e-15
Identities = 65/195 (33%), Positives = 86/195 (44%), Gaps = 19/195 (9%)
Query: 129 GLRNHGNTCFMNATLQCLSNTELFAEY---LALGQYRAGRPEPSPDPEQPAGR-----GA 180
GLRN GNTCFMNA LQ LSN E F Y L + R G+ AGR +
Sbjct: 160 GLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGK---------TAGRRTYHTRS 210
Query: 181 QGQGEVT--EQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLD 238
QG V+ E+ + ALW T +V K +RG Q DA EF+ +LLD
Sbjct: 211 QGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLD 270
Query: 239 RVHEDLNHSVKQSGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQ 298
+H +L + + + T ST V +F ++ + C C +
Sbjct: 271 HLHLELQGGFNGVSRSAILQENSTLSASNKCCINGASTVVTAIFGGILQNEVNCLICGTE 330
Query: 299 SNTFDPFLCISLPIP 313
S FDPFL +SL IP
Sbjct: 331 SRKFDPFLDLSLDIP 345
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 97.4 bits (241), Expect = 8e-20
Identities = 58/180 (32%), Positives = 86/180 (47%), Gaps = 19/180 (10%)
Query: 591 HQPQTCTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQ 650
H T TL+ C + +T+ E L +C C Q+ + L++ LP V HLKRF
Sbjct: 355 HVSGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEH 414
Query: 651 EGDRRMKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYI---- 706
R K+ V FPL LDMTP + +S R G + P D +
Sbjct: 415 SAKLRRKITTYVSFPLE-LDMTPFMASSKES------------RMNGQYQQPTDSLNNDN 461
Query: 707 -YDLYAVCNHHGTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRR 765
Y L+AV NH GT++ GHYT++ + D W+ DD+ + + S +V Y+LFY ++
Sbjct: 462 KYSLFAVVNHQGTLESGHYTSFIRQHKD-QWFKCDDAIITKASIKDVLDSEGYLLFYHKQ 520
Score = 67.0 bits (162), Expect = 1e-10
Identities = 49/188 (26%), Positives = 77/188 (40%), Gaps = 29/188 (15%)
Query: 126 GVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGE 185
G+ GL N GNTCFMN +Q L++T L ++ ++R PS
Sbjct: 174 GLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPS--------------SC 219
Query: 186 VTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLN 245
+ +++ L + ++ +P +V +A G Q DA EFL+ LD +H
Sbjct: 220 LVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLH---R 276
Query: 246 HSVKQSGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPF 305
H P+ C+ + ++F +S +TC C S T DPF
Sbjct: 277 HCKGDDNGKKANNPNH------------CNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPF 324
Query: 306 LCISLPIP 313
ISL +P
Sbjct: 325 WDISLDLP 332
>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
Length = 438
Score = 97.1 bits (240), Expect = 1e-19
Identities = 54/175 (30%), Positives = 87/175 (49%), Gaps = 9/175 (5%)
Query: 591 HQPQTCTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQ 650
H P TL+ C + +T+ E L +C C+ Q+ + L++ LP V H KRF
Sbjct: 256 HIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEH 315
Query: 651 EGDRRMKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLY 710
+R K+ + FPL LDMTP + +S + + P G + Y L+
Sbjct: 316 SAKQRRKITTYISFPLE-LDMTPFMASSKESRMN-----GQLQLPTNSGNNENK--YSLF 367
Query: 711 AVCNHHGTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRR 765
AV NH GT++ GHYT++ ++ D W+ DD+ + + S +V Y+LFY ++
Sbjct: 368 AVVNHQGTLESGHYTSFIRHHKD-QWFKCDDAVITKASIKDVLDSEGYLLFYHKQ 421
Score = 64.7 bits (156), Expect = 6e-10
Identities = 49/188 (26%), Positives = 78/188 (41%), Gaps = 29/188 (15%)
Query: 126 GVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGE 185
G+ GL N GNTCFMN +Q L++T + ++ ++R P P +
Sbjct: 76 GLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSP--------------ELC 121
Query: 186 VTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLN 245
+ +++ L R L++ +P +V +A G Q DA EFL+ LD +H
Sbjct: 122 LVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLH---R 178
Query: 246 HSVKQSGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPF 305
H P+ C+ + ++F +S +TC C S T DP
Sbjct: 179 HCKGDDVGKAANNPNH------------CNCIIDQIFTGGLQSDVTCQACHGVSTTIDPC 226
Query: 306 LCISLPIP 313
ISL +P
Sbjct: 227 WDISLDLP 234
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 95.1 bits (235), Expect = 4e-19
Identities = 53/167 (31%), Positives = 81/167 (48%), Gaps = 25/167 (14%)
Query: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRM 656
+L CF L+TKEE L ++A C C+Q + + L++ P +L++HL RF
Sbjct: 415 SLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIK 474
Query: 657 KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHH 716
K V FPL L + ++ S +Y LYA+CNH
Sbjct: 475 KSSVGVDFPLQRLSLGDFASDKAGSP-----------------------VYQLYALCNHS 511
Query: 717 GTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQ 763
G++ GHYTA C+ W+ ++DS V +SE++V + Y+LFYQ
Sbjct: 512 GSVHYGHYTALCRCQTG--WHVYNDSRVSPVSENQVASSEGYVLFYQ 556
Score = 93.6 bits (231), Expect = 1e-18
Identities = 68/210 (32%), Positives = 98/210 (46%), Gaps = 36/210 (17%)
Query: 126 GVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGE 185
G GLRN GNTCF+NA LQCLS+T ++ +R E P G AQ E
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFR---------QEVPGGGRAQ---E 257
Query: 186 VTEQLAHLVRALWTLEYTPQ-HSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDL 244
+TE A ++ ALW + + F+ + K + G SQ DAQEFL L++R+H ++
Sbjct: 258 LTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEI 317
Query: 245 NHSVKQSGQPPL-------KPPSETDMMPEGPSFPVC--------------STFVQELFQ 283
N +++ PP+ PP + E P + + +LF
Sbjct: 318 NRRGRRA--PPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFV 375
Query: 284 AQYRSSLTCPHCQKQSNTFDPFLCISLPIP 313
Q +S L C C +S TF+ F +SLPIP
Sbjct: 376 GQLKSCLKCQACGYRSTTFEVFCDLSLPIP 405
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 95.1 bits (235), Expect = 4e-19
Identities = 53/167 (31%), Positives = 81/167 (48%), Gaps = 25/167 (14%)
Query: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRM 656
+L CF L+TKEE L ++A C C+Q + + L++ P +L++HL RF
Sbjct: 415 SLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIK 474
Query: 657 KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHH 716
K V FPL L + ++ S +Y LYA+CNH
Sbjct: 475 KSSVGVDFPLQRLSLGDFASDKAGSP-----------------------VYQLYALCNHS 511
Query: 717 GTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQ 763
G++ GHYTA C+ W+ ++DS V +SE++V + Y+LFYQ
Sbjct: 512 GSVHYGHYTALCRCQTG--WHVYNDSRVSPVSENQVASSEGYVLFYQ 556
Score = 93.6 bits (231), Expect = 1e-18
Identities = 68/210 (32%), Positives = 98/210 (46%), Gaps = 36/210 (17%)
Query: 126 GVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGE 185
G GLRN GNTCF+NA LQCLS+T ++ +R E P G AQ E
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFR---------QEVPGGGRAQ---E 257
Query: 186 VTEQLAHLVRALWTLEYTPQ-HSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDL 244
+TE A ++ ALW + + F+ + K + G SQ DAQEFL L++R+H ++
Sbjct: 258 LTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEI 317
Query: 245 NHSVKQSGQPPL-------KPPSETDMMPEGPSFPVC--------------STFVQELFQ 283
N +++ PP+ PP + E P + + +LF
Sbjct: 318 NRRGRRA--PPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFV 375
Query: 284 AQYRSSLTCPHCQKQSNTFDPFLCISLPIP 313
Q +S L C C +S TF+ F +SLPIP
Sbjct: 376 GQLKSCLKCQACGYRSTTFEVFCDLSLPIP 405
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 88.2 bits (217), Expect = 5e-17
Identities = 129/573 (22%), Positives = 215/573 (37%), Gaps = 34/573 (5%)
Query: 772 SANSSVAGSTSSSLCEHWVSRLPGSKPASVTSAASSRRTSLASLSESVEMTGERSEDDGG 831
S++S + S SS + S S +S +S +S +S +S S + +SE D
Sbjct: 577 SSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSD--SSDSSDSSDSKSDSSKSESDSS 634
Query: 832 FSTRPFVRSVQRQSLSSRSSVTSPLAVNENCMRPSWSLSAKLQMRSNSPSRFSGDSPIHS 891
S S S SS +S +S + + N S S S S+S S S DS S
Sbjct: 635 DSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDS-SDSSDSSSSSDSSNSSDSSDSS 693
Query: 892 SASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVFKD 951
+S + +++D S S S SS SDS S D
Sbjct: 694 DSSNSSESSDSSDSSDSDSSDSS----DSSNSNSSDSDSSNS----------------SD 733
Query: 952 ESDTRRLNSSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSH 1011
SD+ + S + S +S+ S D+++ D SDS DSS + S+
Sbjct: 734 SSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS---DSSDSSDSSN----SSDSN 786
Query: 1012 PGSLAKKPESTTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKPS 1071
S + ++ S SS + + S + S +SS SS S S S S
Sbjct: 787 DSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDS----SNSSDSS 842
Query: 1072 RSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASSTSAK 1131
S +D S S S + + +SS S S SS S +S+++ + SS S+
Sbjct: 843 DSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSD 902
Query: 1132 KASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPNSPRVSQARAGEGRG 1191
S ++ S S +SD S S S S SD ++++ +S + S +
Sbjct: 903 SDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDS 962
Query: 1192 AGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETRRSTDLGKTALLS 1251
+ S S +S S S++ S+ S ++ ++ S+D ++ S
Sbjct: 963 SNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSS 1022
Query: 1252 KKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPASAKHSLLSARKS 1311
+ S+ ++ ++ S + ++ + + D + + S S+ S
Sbjct: 1023 NSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1082
Query: 1312 KSSQLDSGVPSSPGGRQSAEKSSKKLSSSMQTS 1344
+SS SS S S S S +S
Sbjct: 1083 ESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1115
Score = 85.5 bits (210), Expect = 3e-16
Identities = 127/577 (22%), Positives = 212/577 (36%), Gaps = 12/577 (2%)
Query: 770 SWSANSSVAGSTSSSLCEHWVSRLPGSKPASVTSAASSRRTSLASLSESVEMTGERSEDD 829
S S++SS + +S S S S +S + ++ S +S ++ S+S S D
Sbjct: 678 SSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDS 737
Query: 830 GGFSTRPFVRSVQRQSLSSRSSVTSPLAVNENCMRPSWSLSAKLQMRSNSPSRFSGDSPI 889
S S SS SS +S + + + S S + SN S S DS
Sbjct: 738 SNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSN-SSDSSD 796
Query: 890 HSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVF 949
S++S +++D S S + SS+ + SDS + + + +G
Sbjct: 797 SSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS----DG-- 850
Query: 950 KDESDTRRLNSSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAP 1009
+SD+ + S + S S+ S D+N D SDS +SS +
Sbjct: 851 -SDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSS 909
Query: 1010 SHPGSLAKKPESTTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLK 1069
+ S S + S +S S S + +S S+ S +S SS
Sbjct: 910 NSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 969
Query: 1070 PSRSRSKADSS-SRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASST 1128
S S +DSS S S S + + +SS S S SS S S+ + + SS
Sbjct: 970 DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSN 1029
Query: 1129 SAKKA-SGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPNSPRVSQARAG 1187
S+ + S ++ S S +SD S S + S S SD + ++ +S + S +
Sbjct: 1030 SSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSD 1089
Query: 1188 EGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETRRSTDLGKT 1247
+ S S S S +S S S S D S + ++ S+D +
Sbjct: 1090 SSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDS--SDSSDSSDSSNSSDSSDS 1147
Query: 1248 ALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPASAKHSLLS 1307
+ S + S ++ ++ S + ++ + + D + + S S
Sbjct: 1148 SESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1207
Query: 1308 ARKSKSSQLDSGVPSSPGGRQSAEKSSKKLSSSMQTS 1344
+ S SS SS S S S S +S
Sbjct: 1208 SDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSS 1244
Score = 82.8 bits (203), Expect = 2e-15
Identities = 118/524 (22%), Positives = 182/524 (34%), Gaps = 18/524 (3%)
Query: 823 GERSEDDGGFSTRPFVRSVQRQSLSSRSSVTSPLA-VNENCMRPSWSLSAKLQMRSNSPS 881
G DD S +S S SS SS +S + +++ S S S S+S
Sbjct: 530 GNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSD 589
Query: 882 RFSGDSPIHSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAP 941
DS S++S +++D S S + S S + SDS S+ +
Sbjct: 590 SSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSS------ 643
Query: 942 LAVMEGVFKDESDTRRLNSSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSS 1001
+ D SD + S + S S+ S D++N D SDS +SS
Sbjct: 644 ----DSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSS 699
Query: 1002 PVKEVKAPSHPGSLAKKPESTTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSP 1061
+ S S S + S S S + S +SS SS S S
Sbjct: 700 ESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS- 758
Query: 1062 LPVKVSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASAL 1121
S + S S S S S S+ + + SS S S SS S S+ +
Sbjct: 759 -----SDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSS 813
Query: 1122 TYTASSTSAKKASGPATRSPFPPGKSRTSDHSLSREGS-RQSLGSDRASATSTSKPNSPR 1180
+ S +S S ++ S S +SD S S +GS S +S +S S +S
Sbjct: 814 DSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDS 873
Query: 1181 VSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETRR 1240
+ + + + + + SS + + S S S S S D S S
Sbjct: 874 SNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNS 933
Query: 1241 STDLGKTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPAS 1300
++ + S + SS S N+ D S + ++ + + D +
Sbjct: 934 NSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSD 993
Query: 1301 AKHSLLSARKSKSSQLDSGVPSSPGGRQSAEKSSKKLSSSMQTS 1344
+ S S+ S SS SS S S S S +S
Sbjct: 994 SSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSS 1037
Score = 80.5 bits (197), Expect = 1e-14
Identities = 122/583 (20%), Positives = 214/583 (36%), Gaps = 12/583 (2%)
Query: 772 SANSSVAGSTSSSLCEHWVSRLPGSKPASVTSAASSRRTSLASLSESVEMTGERSEDDGG 831
S++SS + +S S + S S S + ++ S + + S+S + + + D
Sbjct: 610 SSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSS 669
Query: 832 FSTRPFVRSVQRQSL----SSRSSVTSPLAVNENCMRPSWSLSAKLQMRSNSPSRFSGDS 887
S+ S S SS SS +S + + + S S S+ SNS S S S
Sbjct: 670 DSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSS 729
Query: 888 PIHSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEG 947
S+ + + S S S + SS+ + SDS + + +
Sbjct: 730 NSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSS 789
Query: 948 VFKDESDTRRLNSSVVDTQSKHSAQGD-----RLPPLSGPFDNNNQIAYVDQSDSVDSSP 1002
D SD+ + S + S S+ S D+++ D SDS DSS
Sbjct: 790 NSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSD 849
Query: 1003 VKEVKAPSHPGSLAKKPESTTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPL 1062
+ + + S S + S +S +S+ S + +S S+ S + S
Sbjct: 850 GSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSS 909
Query: 1063 PVKVSLKPSRSRSKADSSSRGSGRHSSPAP-AQPKKESSPKSQDSVSSPSPQKQKSASAL 1121
S S S ++SS+ +SS + + +SS S S SS S S+ +
Sbjct: 910 NSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 969
Query: 1122 TYTASSTSAKKASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPNSPRV 1181
+S +S S ++ S S +SD S S + S S SD ++++ +S +
Sbjct: 970 DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSN 1029
Query: 1182 SQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETRRS 1241
S + + S S S S ++S S S S D S + E+ S
Sbjct: 1030 SSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDS--SDSSDSSESSDS 1087
Query: 1242 TDLGKTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPASA 1301
+D ++ S + S ++ ++ S + ++ + + D + +
Sbjct: 1088 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDS 1147
Query: 1302 KHSLLSARKSKSSQLDSGVPSSPGGRQSAEKSSKKLSSSMQTS 1344
S S+ S SS SS S +S S S +S
Sbjct: 1148 SESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1190
Score = 79.0 bits (193), Expect = 3e-14
Identities = 121/535 (22%), Positives = 193/535 (36%), Gaps = 27/535 (5%)
Query: 772 SANSSVAGSTSSSLCEHWVSRLPGSKPASVTSAASSRRTSLASLSESVEMTGERSEDDGG 831
S+NSS + +S+S S S +S + +++S +S + S+S + + D
Sbjct: 788 SSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSS--NSSDSSDSSNSSDSSDSS 845
Query: 832 FSTRPFVRSVQRQSLSSRSSVTSPLAVNENCMRPSWSLSAKLQMRSN--SPSRFSGDSPI 889
S+ +S SS SS +S + + N S S + S+ S S S DS
Sbjct: 846 DSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDS 905
Query: 890 HSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVF 949
S+++ + + S S S + SS SDS + + +
Sbjct: 906 SDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNS 965
Query: 950 KDESDTRRLNSSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAP 1009
D SD+ +SS S S D S D++N D SDS DSS +
Sbjct: 966 SDSSDSNSSDSSDSSNSSDSSDSSDSSDS-SDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024
Query: 1010 SHPGSLAKKPESTTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLK 1069
S + + +S+ S S + S +SS SS S S
Sbjct: 1025 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDS--------- 1075
Query: 1070 PSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASSTS 1129
S S S S S S + + +SS S S SS S S+ +S +S
Sbjct: 1076 SDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD-----SSDSS 1130
Query: 1130 AKKASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPNSPRVSQARAGEG 1189
S ++ S S +SD S S + S S SD + ++ +S ++ S +
Sbjct: 1131 DSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1190
Query: 1190 RGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETRRSTDLGKTAL 1249
+ S S S S +S S S S D + E+ S+D ++
Sbjct: 1191 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS-----SDSSDSNESSDSSDSSDSSD 1245
Query: 1250 LSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPASAKHS 1304
S + S +T D E Q S+ N N G + + + + HS
Sbjct: 1246 SSNSSDSSDSSDSSDSTSDSNDESDSQ---SKSGNGNNNGSDSDSDSEGSDSNHS 1297
Score = 76.6 bits (187), Expect = 1e-13
Identities = 111/463 (23%), Positives = 171/463 (36%), Gaps = 25/463 (5%)
Query: 772 SANSSVAGSTSSSLCEHWVSRLPGSKPA-SVTSAASSRRTSLASLSESVEMTGERSEDDG 830
S++SS + +S +R S + S S+ SS + + S+S E + D
Sbjct: 838 SSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDS 897
Query: 831 GFSTRPFVRSVQRQSLSSRSSVTSPLAVNENCMRPSWSLSAKLQMRSNSPSRFSGDSPIH 890
S+ S SS SS +S + + N S S S +S S S +S
Sbjct: 898 SNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNS-SDSSNSSDSSDSSDSSNSSDS 956
Query: 891 SSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVFK 950
S++S +++D S S S + SS + SDS + + +
Sbjct: 957 SNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1016
Query: 951 DESDTRRLNSSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPS 1010
+ SD+ + S + S S+ S D+++ D SDS DSS + S
Sbjct: 1017 NSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1076
Query: 1011 HPGSLAKKPESTTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKP 1070
++ +S+ + S S + S +SS SS S S S
Sbjct: 1077 DSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1136
Query: 1071 SRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASSTSA 1130
S S S S S S + + +SS S S SS S S+ + + SS S+
Sbjct: 1137 DSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1196
Query: 1131 KKA----------SGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRA------------ 1168
+ S ++ S S +SD S S E S S SD +
Sbjct: 1197 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSS 1256
Query: 1169 -SATSTSKPNSPRVSQARAGEGRGAGKHVRSSSMASLRSPSTS 1210
S+ STS N SQ+++G G G S S S + STS
Sbjct: 1257 DSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTS 1299
Score = 76.3 bits (186), Expect = 2e-13
Identities = 122/537 (22%), Positives = 206/537 (38%), Gaps = 23/537 (4%)
Query: 816 SESVEMTGERSEDDGGFSTRPFVRSVQRQSLSSRSSVTSPLAVNENCMRPSWSLSAKLQM 875
S+S + + S+ D S+ S S SS S+ +S ++ S S+
Sbjct: 540 SDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSD-------SDSSDSSD 592
Query: 876 RSNSPSRFSGDSPIHSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSR--RE 933
+S S S DS S +S +++D K S S + S S + SDS+S +
Sbjct: 593 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSD 652
Query: 934 HKAVGRAPLAVMEGVFKDESDTRRLNSSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVD 993
+ + + D SD+ +SS + S S+ S D+++ + D
Sbjct: 653 NSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDS-SDSD 711
Query: 994 QSDSVDSSPVKEVKAPSHPGSLAKKPESTTKRSPS--SKGTSEPEKSLRKGRPALASQES 1051
SDS DSS + S S + +++ S S S +S+ S + +S S
Sbjct: 712 SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 771
Query: 1052 SLSSTSPSSPLPVKVSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPS 1111
S +S SS S + S + +DSS + SS + S S S SS S
Sbjct: 772 DSSDSSDSSN-----SSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDS 826
Query: 1112 PQKQKSASALTYTASSTSAKKASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASAT 1171
S+ + + SS S+ + G + S S +SD S S + S S SD +S +
Sbjct: 827 SNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSD-SSDS 885
Query: 1172 STSKPNSPRVSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKS 1231
+ S +S + + + + S S S S +S S +S S D S S
Sbjct: 886 NESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSS 945
Query: 1232 ----ALRQKETRRSTDLGKTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNANT 1287
+ ++ S+D ++ S S S + D ++ +S N++
Sbjct: 946 DSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSD 1005
Query: 1288 TGKEQLVTKDPASAKHSLLSARKSKSSQLDSGVPSSPGGRQSAEKSSKKLSSSMQTS 1344
+ + + D +++ S S+ S SS SS S S S+S +S
Sbjct: 1006 S-SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS 1061
Score = 75.5 bits (184), Expect = 3e-13
Identities = 106/474 (22%), Positives = 166/474 (35%), Gaps = 40/474 (8%)
Query: 877 SNSPSRFSGDSPIHSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKA 936
++S S S DS S S+ + +D S S + SS + SDS
Sbjct: 559 NSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDS-------- 610
Query: 937 VGRAPLAVMEGVFKDESDTRRLNSSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSD 996
D SD+ + S D+ S D D+ + + + SD
Sbjct: 611 -------------SDSSDSSDSSDSKSDSSKSESDSSDS--------DSKSDSSDSNSSD 649
Query: 997 SVDSSPVKEVKAPSHPGSLAKKPESTTKRSPSSKGTSEPEKSLRKGRPALASQESSLSST 1056
S D+S + S+ + +S+ S S S + S +SS SS
Sbjct: 650 SSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD 709
Query: 1057 SPSSPLPVKVSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQK 1116
S SS + S S S S S S S + + SS S S SS S
Sbjct: 710 SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSD 769
Query: 1117 SASALTYTASSTSAKKASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKP 1176
S+ + + SS S+ S ++ S S +SD S S + S S SD S+ S+
Sbjct: 770 SSDSSDSSDSSNSSD--SNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSS 827
Query: 1177 NSPRVSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQK 1236
NS S + S + + S S S DS S+ S +
Sbjct: 828 NSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDS-SDSSNSSDSSDSSDSN 886
Query: 1237 ETRRSTDLGKTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNA--NTTGKEQLV 1294
E+ S+D S + S S + D ++ + +S+ N+ N+ +
Sbjct: 887 ESSNSSD------SSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSN 940
Query: 1295 TKDPASAKHSLLSARKSKSSQLDSGVPSSPGGRQSAEKSSKKLSSSMQTSARPS 1348
+ D + + S S+ S SS + SS + SS SS + + S
Sbjct: 941 SSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDS 994
Score = 74.7 bits (182), Expect = 6e-13
Identities = 112/472 (23%), Positives = 177/472 (37%), Gaps = 34/472 (7%)
Query: 878 NSPSRFSGDSPIHSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAV 937
+S S S S +SS+ + +++D S S S + SS + SDS +
Sbjct: 563 SSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSS-- 620
Query: 938 GRAPLAVMEGVFKDESDTRRLNSSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDS 997
+SD+ + S D+ SK + S DN++ + S+S
Sbjct: 621 ------------DSKSDSSKSESDSSDSDSKSDSSDSNSSDSS---DNSDSSDSSNSSNS 665
Query: 998 VDSSPVKEVKAPSHPGSLAKKPESTTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTS 1057
DSS + S S + +++ S SS ++ E S S +SS SS S
Sbjct: 666 SDSSD----SSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNS 721
Query: 1058 PSSPLPVKVSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKS 1117
SS S S S + +DSS +SS + +S S DS S S S
Sbjct: 722 NSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDS-SDSSDSSDSS 780
Query: 1118 ASALTYTASSTSAKKASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPN 1177
S+ + +S++S S ++ S S +SD S S S S S +S +S S +
Sbjct: 781 NSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDS--DSSNSSDSSNSSDSSDSSNS 838
Query: 1178 SPRVSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKE 1237
S + + +G + RS S S S +S S S S D S S
Sbjct: 839 SDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSS 898
Query: 1238 TRRSTDLGKTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKD 1297
+D S + SS S N+ D ++ ++N++ + D
Sbjct: 899 NSSDSD-------SSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD--SSD 949
Query: 1298 PASAKHSLLSARKSKSS-QLDSGVPSSPGGRQSAEKSSKKLSSSMQTSARPS 1348
+++ S S+ S SS DS S S++ S SS S+ S
Sbjct: 950 SSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1001
Score = 43.5 bits (101), Expect = 0.001
Identities = 70/385 (18%), Positives = 120/385 (31%), Gaps = 14/385 (3%)
Query: 962 VVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVK--EVKAPSHPGSLAKKP 1019
+ DTQ + + R+ N+I ++ +V S K E+K PS K
Sbjct: 341 IEDTQKLNHRESKRV---------ENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKE 391
Query: 1020 ESTTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKPSRSRSKADS 1079
KG + L KG + ++ S KV + S S +D
Sbjct: 392 VGKGNEGKEDKG--QHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDG 449
Query: 1080 SSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASSTSAKKASGPATR 1139
S P D +S S S +Y S S +G ++
Sbjct: 450 YDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYN-SDESKDNGNGSDSK 508
Query: 1140 SPFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPNSPRVSQARAGEGRGAGKHVRSS 1199
TSD + S + G+D + + K S + + S
Sbjct: 509 GAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSD 568
Query: 1200 SMASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETRRSTDLGKTALLSKKAGGSSV 1259
S +S + S+ S S S D S ++ ++ S+D ++ S SS
Sbjct: 569 SDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSK 628
Query: 1260 KSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPASAKHSLLSARKSKSSQLDSG 1319
+ D +++ + N++++ +S + S S S
Sbjct: 629 SESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSD 688
Query: 1320 VPSSPGGRQSAEKSSKKLSSSMQTS 1344
S S+E S SS +S
Sbjct: 689 SSDSSDSSNSSESSDSSDSSDSDSS 713
>gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]
Length = 712
Score = 85.5 bits (210), Expect = 3e-16
Identities = 64/185 (34%), Positives = 84/185 (45%), Gaps = 32/185 (17%)
Query: 594 QTCTLSQCFQLYTKEERLAPDDAWRCPHCKQ-----------LQQGSITLSLWTLPDVLI 642
Q C +++ +T+ E L + C C L + L + LP VL
Sbjct: 513 QPCLVTEMLAKFTETEALE-GKIYVCDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLR 571
Query: 643 IHLKRFRQEG-DRRMKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRD 701
+HLKRFR G + R K+ V F L+M P+ + + S
Sbjct: 572 LHLKRFRWSGRNNREKIGVHVGFEEI-LNMEPYCCRETLKSLR----------------- 613
Query: 702 PEDYIYDLYAVCNHHGTMQG-GHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYIL 760
PE +IYDL AV HHG G GHYTAYC NS G W +DS + + DEVC AYIL
Sbjct: 614 PECFIYDLSAVVMHHGKGFGSGHYTAYCYNSEGGFWVHCNDSKLSMCTMDEVCKAQAYIL 673
Query: 761 FYQRR 765
FY +R
Sbjct: 674 FYTQR 678
Score = 68.6 bits (166), Expect = 4e-11
Identities = 65/239 (27%), Positives = 98/239 (41%), Gaps = 58/239 (24%)
Query: 125 PGVAGLRNHGNTCFMNATLQCLSNTELFAEY---LALGQY---------RAGRPEPSPDP 172
PGV GLRN GNTC+MN+ LQ LS+ +F + L L Q+ R+ + P D
Sbjct: 270 PGVTGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKLDLNQWLAMTASEKTRSCKHPPVTDT 329
Query: 173 ---------EQPAG-------------RGAQGQGEVTE----------------QLAHLV 194
E+ G G +G E +L L
Sbjct: 330 VVYQMNECQEKDTGFVCSRQSSLSSGLSGGASKGRKMELIQPKEPTSQYISLCHELHTLF 389
Query: 195 RALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQP 254
+ +W+ ++ V + +RG +Q DAQEFL LLD++ +L + + P
Sbjct: 390 QVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQRELETT--GTSLP 447
Query: 255 PLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIP 313
L P S+ ++ + V +F Q S +TC C +SNT +PF +SL P
Sbjct: 448 ALIPTSQRKLIKQ------VLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFP 500
>gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens]
Length = 712
Score = 85.5 bits (210), Expect = 3e-16
Identities = 64/185 (34%), Positives = 84/185 (45%), Gaps = 32/185 (17%)
Query: 594 QTCTLSQCFQLYTKEERLAPDDAWRCPHCKQ-----------LQQGSITLSLWTLPDVLI 642
Q C +++ +T+ E L + C C L + L + LP VL
Sbjct: 513 QPCLVTEMLAKFTETEALE-GKIYVCDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLR 571
Query: 643 IHLKRFRQEG-DRRMKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRD 701
+HLKRFR G + R K+ V F L+M P+ + + S
Sbjct: 572 LHLKRFRWSGRNNREKIGVHVGFEEI-LNMEPYCCRETLKSLR----------------- 613
Query: 702 PEDYIYDLYAVCNHHGTMQG-GHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYIL 760
PE +IYDL AV HHG G GHYTAYC NS G W +DS + + DEVC AYIL
Sbjct: 614 PECFIYDLSAVVMHHGKGFGSGHYTAYCYNSEGGFWVHCNDSKLSMCTMDEVCKAQAYIL 673
Query: 761 FYQRR 765
FY +R
Sbjct: 674 FYTQR 678
Score = 68.6 bits (166), Expect = 4e-11
Identities = 65/239 (27%), Positives = 98/239 (41%), Gaps = 58/239 (24%)
Query: 125 PGVAGLRNHGNTCFMNATLQCLSNTELFAEY---LALGQY---------RAGRPEPSPDP 172
PGV GLRN GNTC+MN+ LQ LS+ +F + L L Q+ R+ + P D
Sbjct: 270 PGVTGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKLDLNQWLAMTASEKTRSCKHPPVTDT 329
Query: 173 ---------EQPAG-------------RGAQGQGEVTE----------------QLAHLV 194
E+ G G +G E +L L
Sbjct: 330 VVYQMNECQEKDTGFVCSRQSSLSSGLSGGASKGRKMELIQPKEPTSQYISLCHELHTLF 389
Query: 195 RALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQP 254
+ +W+ ++ V + +RG +Q DAQEFL LLD++ +L + + P
Sbjct: 390 QVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQRELETT--GTSLP 447
Query: 255 PLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIP 313
L P S+ ++ + V +F Q S +TC C +SNT +PF +SL P
Sbjct: 448 ALIPTSQRKLIKQ------VLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFP 500
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 84.3 bits (207), Expect = 7e-16
Identities = 127/536 (23%), Positives = 206/536 (38%), Gaps = 69/536 (12%)
Query: 795 GSKPASVTSAASSRRTSLASLS---ESVEMTGERSEDDGGFSTRPFVRSVQRQSLSSRSS 851
GS P + + R SL+ S + + T R + S P Q+ RS
Sbjct: 1442 GSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEP---KALPQTPRPRSR 1498
Query: 852 VTSPLAVNENCMRPSWSLSAKLQMRSNSPSRFSGDSPIHSSASTLEKIGEAADDKVSISC 911
S +N C+ P R S S S D + ++ + ++ +
Sbjct: 1499 SPSSPELNNKCLTPQ---------RERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKP 1549
Query: 912 FGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVFKDESDTRRLNSSVVDTQSKHSA 971
S+S QE S+S S + KA R PL +R +S VD++S+ S
Sbjct: 1550 -------SASPQERSESDSSPDSKAKTRTPL---------RQRSRSGSSPEVDSKSRLSP 1593
Query: 972 QGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSHPGSLAKKPESTTKRSPSSKG 1031
+ R S P + A DSSP + AP ++ S+ R PS +G
Sbjct: 1594 RRSRSG--SSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEG 1651
Query: 1032 TSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKPSRSRSKADSSSRGSGRHSSPA 1091
+S E S + ++ S SS P + + SRS + +R S R S +
Sbjct: 1652 SSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSAS 1711
Query: 1092 PAQPKKESSP---KSQDSVSSPSPQKQKSASALTYTASSTSAKKASGPA-TRSPFPPGKS 1147
+ + +P + SVSSP P ++ +S +ASS K S + SP P G
Sbjct: 1712 SSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQ 1771
Query: 1148 RTSDHSLSREGSRQSLGSDRA-SATSTSKPNSPRVSQARAGEGR--GAGKHVRSSSMASL 1204
R+ S RE +R + DR+ S+ STS+ S++R R G+G H RS +
Sbjct: 1772 RSRSRS-RREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQES 1830
Query: 1205 RSPSTSIKSGLKRD-------SKSEDKGLSFFKSALRQKETRRSTDLGKTALLSKKAGGS 1257
S+ + G R S+S + +S R +T L+S++
Sbjct: 1831 SRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRR---- 1886
Query: 1258 SVKSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPASAKHSLLSARKSKS 1313
R P S++ + + T VT+ + ++ S +S R+S+S
Sbjct: 1887 -------------RSRSRTSPVSRRRSRSRTS----VTRRRSRSRASPVSRRRSRS 1925
Score = 73.6 bits (179), Expect = 1e-12
Identities = 111/410 (27%), Positives = 160/410 (39%), Gaps = 61/410 (14%)
Query: 798 PASVTSAASSRRTSLASLSESVEMTGERSEDDGGFSTRPFV---RSVQRQSLSSRSSVTS 854
PAS+TSA + S A+L+ S + E G ++ P + RS S S+S +TS
Sbjct: 2363 PASLTSARMAPALSGANLT-SPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTS 2421
Query: 855 PLAVNENC---MRPSWSL--SAKLQMRSNSPSRFSGDSPIHSSASTLEKIGEAADDKVSI 909
A + + PS SL A+ Q RS PS FS S + +T ++
Sbjct: 2422 ERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVA 2481
Query: 910 SCFGSLRNLSSSYQEPSDSHSRREHKAVGRAP----------LAVMEGVFKDESDTRRLN 959
+ S + + P+ H VG P LA ++ + RR +
Sbjct: 2482 TTTSSAGDHNGMLSVPAPGVP---HSDVGEPPASTGAQQPSALAALQ-----PAKERRSS 2533
Query: 960 SSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSHPGSLAKKP 1019
SS + S S+ S S SS + S SL +P
Sbjct: 2534 SSSSSSSSSSSSSS---------------------SSSSSSSSSGSSSSDSEGSSLPVQP 2572
Query: 1020 ESTTKRSPSSKGTSEPEKSLRKGRPA--------LASQESSLSSTSPSSPLPVKVSLKPS 1071
E KR PS T P++++R+GRP S SS SS+S SS S S
Sbjct: 2573 EVALKRVPSP--TPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSS 2630
Query: 1072 RSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASSTSAK 1131
S S + SSS S SSP+PA+P ++ PK S P P +++S S S ++
Sbjct: 2631 SSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPA-SPKKPPPGERRSRSPRKPIDSLRDSR 2689
Query: 1132 KASGPAT--RSPFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPNSP 1179
S R P P R S S GSR+ D S + + +P
Sbjct: 2690 SLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETP 2739
Score = 72.4 bits (176), Expect = 3e-12
Identities = 73/269 (27%), Positives = 113/269 (42%), Gaps = 43/269 (15%)
Query: 978 PLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSHPGS-LAKKPESTTKRSPSSKGTSEPE 1036
P++G ++ S + D + + V AP P S + + P ST + PS+ +P
Sbjct: 2468 PVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPA 2527
Query: 1037 KSLRKGRPALASQESSLSSTSPSS-----------------PLPVKVSLKPSRSRSKADS 1079
K R + +S SS SS+S SS P+ +V+LK S + A
Sbjct: 2528 KERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPK 2587
Query: 1080 SSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASSTSAKKASGPATR 1139
+ GR P PA+ K+ SS S S SS S S+S+ + ++SS+S+ +S ++
Sbjct: 2588 EAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2647
Query: 1140 SPFP--PG------------------KSRTSDHSLSREGSRQSLGSDRASATSTSKPNSP 1179
SP P PG +SR+ + +SL S SP
Sbjct: 2648 SPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSP 2707
Query: 1180 RVSQARAGEGRGAGKHVRSSSMASLRSPS 1208
R Q+ + E RG+ + R S RSPS
Sbjct: 2708 RDQQSSSSE-RGSRRGQRGDS----RSPS 2731
Score = 64.3 bits (155), Expect = 8e-10
Identities = 104/467 (22%), Positives = 163/467 (34%), Gaps = 65/467 (13%)
Query: 916 RNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVFKDESDTRR-------LNSSVVDTQSK 968
R+ S+ SD+ R A + + G + RR TQ
Sbjct: 262 RSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRP 321
Query: 969 HSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPS-----------HPGS--- 1014
S + P S P+++ ++ + SP + P H GS
Sbjct: 322 SSPETATKQP-SSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQP 380
Query: 1015 LAKKPESTTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKPSRSR 1074
LA P S +P S+ + ++S K L +SS S +SP SP P KVS
Sbjct: 381 LATTPLSQEPVNPPSEASPTRDRSPPKSPEKLP--QSSSSESSPPSPQPTKVS------- 431
Query: 1075 SKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTAS-----STS 1129
RH+S +P PK +P S +SS K +S S S
Sbjct: 432 -----------RHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRR 480
Query: 1130 AKKASGPAT--------RSPFPPGKSRTSDHSLSREGSRQSLGSDRASAT--STSKPNSP 1179
++ PAT R+P G SR+ R S Q G R+ + P P
Sbjct: 481 MGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRP 540
Query: 1180 RVSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETR 1239
S++R + RG + R S RSP+T G R +G S ++ R++
Sbjct: 541 GWSRSRNTQRRGRSRSARRGRSHS-RSPAT---RGRSRSRTPARRGRSRSRTPARRRSRS 596
Query: 1240 RSTDLGKTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPA 1299
R+ ++ + G S + S+ P A +G+ + T
Sbjct: 597 RTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSP-ARRSGRSRSRTPARR 655
Query: 1300 SAKHSLLSARKSKSSQLDSGVPSSPGGRQSAEKSSKKLSSSMQTSAR 1346
S AR+ +S S P+ GR + +++ S +T R
Sbjct: 656 GRSRSRTPARRGRSR---SRTPARRSGRSRSRTPARRGRSRSRTPRR 699
Score = 63.5 bits (153), Expect = 1e-09
Identities = 124/544 (22%), Positives = 207/544 (38%), Gaps = 63/544 (11%)
Query: 842 QRQSLSSRSSVTSPLAVNENCMRPSWSLSAKL--QMRSNSPSRFSGDSPIHSSASTLEKI 899
Q +L + S + V E P+ + + L +++ S S F SP +
Sbjct: 1225 QNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFES-SPEVEERPAVSLT 1283
Query: 900 GEAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVFKDESDTRRLN 959
+ + + S+ + +++SS+ P H EHK + +PL E F + R N
Sbjct: 1284 LDQSQSQASLEAV-EVPSMASSWGGP---HFSPEHKELSNSPLR--ENSFGSPLEFR--N 1335
Query: 960 SSVVDTQSKHSAQGDRLPPLSGPF----------DNNNQIAYVDQSDSVDSSPVKEVKAP 1009
S + T+ + L+GPF D Q S + SP KA
Sbjct: 1336 SGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAG 1395
Query: 1010 SHPGSLAKKP-----ESTTKRSPSSKGTS---------EPEKSLRKG-RPAL--ASQESS 1052
P T R SS +S P + R G P L S S
Sbjct: 1396 MSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPS 1455
Query: 1053 LSSTSPSSPLPVKVSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSP 1112
S S SSP + PSR RS+ DSS +P P + + SSP+ + +P
Sbjct: 1456 RHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRP-RSRSPSSPELNNKCLTPQR 1514
Query: 1113 QKQKSASALTYTASSTSAKKASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASATS 1172
++ S S++ T A+ G +RS G S+ D + S Q +S S
Sbjct: 1515 ERSGSESSVD---QKTVARTPLGQRSRS----GSSQELD--VKPSASPQERSESDSSPDS 1565
Query: 1173 TSKPNSPRVSQARAG-------EGRGAGKHVRSSSMASLR-SPSTSIKSGLKRDSKSEDK 1224
+K +P ++R+G + R + + RS S ++ P + ++ DS E K
Sbjct: 1566 KAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPK 1625
Query: 1225 GLSFFKSALRQKETRRSTDLGKTALLSKKAGGSSVKSVCKNTGDDE-AERGHQPPASQQP 1283
+ AL ++ S+ G+ G SS +S ++ A RG + +
Sbjct: 1626 APA--PRALPRRSRSGSSSKGRG---PSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKT 1680
Query: 1284 NANTTGKEQLVTKDPASAKHSLLSAR-KSKSSQLDSGVPSSPGGRQSAEKSSKKLSSSMQ 1342
+ T + + P + + LS R +S SS ++ + P R+S SS + + +
Sbjct: 1681 KSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSR 1740
Query: 1343 TSAR 1346
+S R
Sbjct: 1741 SSRR 1744
Score = 63.2 bits (152), Expect = 2e-09
Identities = 108/592 (18%), Positives = 221/592 (37%), Gaps = 53/592 (8%)
Query: 794 PGSKPASV-TSAASSRRTSLASLSESVEMTGERSEDDGGFSTRPFVRSVQRQSLSSRSSV 852
P S+P + T SS T+ S E + ++ +TRP S +R S
Sbjct: 309 PFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKS--ATRPSP-SPERSSTGPEPPA 365
Query: 853 TSPLAVNENCMRPSWSLSAKLQMRSNSPSRFSGDSPIHSSASTLEKIGEAADDKVSISCF 912
+PL + P + L +P + + S + EK+ +++ + S
Sbjct: 366 PTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSP 425
Query: 913 GSL---RNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVFKDESD-------TRRLNSSV 962
R+ SSS + P + + H+ + +P + + + D +RR+ S
Sbjct: 426 QPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSR 485
Query: 963 VDTQSKHSAQGDRLPPLSGPFDNNN---QIAYVDQSDSVDSSPVKE--VKAPSHPG---- 1013
+K R P G + + + + Q SP + ++P PG
Sbjct: 486 SPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRS 545
Query: 1014 --------SLAKKPESTTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVK 1065
S + + + RSP+++G S R+GR + S + + +
Sbjct: 546 RNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSR 605
Query: 1066 VSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALT--- 1122
R RS++ + +R R SP + + S + S +P ++ + + T
Sbjct: 606 SRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPAR 665
Query: 1123 --YTASSTSAKKASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPNSPR 1180
+ S T A+++ +R+P G+SR+ R SR + R+ + + +
Sbjct: 666 RGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSG 725
Query: 1181 VSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETRR 1240
S R + R + + RS+S ++ R S + LS +S + + + R
Sbjct: 726 SSSERKNKSRTSQRRSRSNSSPEMKK---------SRISSRRSRSLSSPRSKAKSRLSLR 776
Query: 1241 STDLGKTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPAS 1300
+ G + +K+ +S ++ + PP + +++ K++ +K P+
Sbjct: 777 RSLSGSSPCPKQKSQTPPRRS--RSGSSQPKAKSRTPPRRSRSSSSPPPKQK--SKTPSR 832
Query: 1301 AKHSLLSARKSKSSQLDSGVPSSPGGRQSAEKSSKKLSSSMQTSARPSQKPQ 1352
HS S ++ SG P G S + + + ++ ++ S P+
Sbjct: 833 QSHS----SSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPE 880
Score = 62.0 bits (149), Expect = 4e-09
Identities = 91/365 (24%), Positives = 143/365 (39%), Gaps = 54/365 (14%)
Query: 990 AYVDQSDSVDSSPVKEVKAPSHPGSLAKKPESTTKRSPSSKGTSEPEKSLRKGRPALASQ 1049
+YVD S P + + P KP S + S SS+ + +K +K +
Sbjct: 144 SYVDGSSF---DPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKK------KK 194
Query: 1050 ESSLSSTSPSSPLPVKVSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVS- 1108
+ S S S K S K + RS+++S R +H SP P +K K + S S
Sbjct: 195 DRGRRSESSSPRRERKKSSKKKKHRSESESKKR---KHRSPTPKSKRKSKDKKRKRSRST 251
Query: 1109 SPSPQKQKSASALTYTASSTSAKKASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRA 1168
+P+P+ +++ STSA AS +SD S SR S +
Sbjct: 252 TPAPKSRRA-------HRSTSADSAS--------------SSDTSRSRSRSAAA-----K 285
Query: 1169 SATSTSKPNSPRVSQARAGEGRGAGKHVRSSSMASLRSPSTSIKS-GLKRDSKSEDKGLS 1227
+ T+ SP + R GEG ++S SP T+ K + K +DK
Sbjct: 286 THTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKK-- 343
Query: 1228 FFKSALRQKETRRSTDLG-----KTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQ 1282
KSA R + + G T LL+++ GGS + PP+
Sbjct: 344 -EKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPV----NPPSEAS 398
Query: 1283 PNAN-TTGKEQLVTKDPASAKHSLLSARKSKSSQLDSGVPSSPGGRQSAEKSSKKLSSSM 1341
P + + K +S++ S S + +K S+ S P SP A S +++SSS
Sbjct: 399 PTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESP-KPAPAPGSHREISSSP 457
Query: 1342 QTSAR 1346
+ R
Sbjct: 458 TSKNR 462
Score = 62.0 bits (149), Expect = 4e-09
Identities = 110/472 (23%), Positives = 168/472 (35%), Gaps = 67/472 (14%)
Query: 807 SRRTSLASLSESVEMTGERSEDDGGFSTRPFV-RSVQRQSLSSRSSVTSPLAVNENCMRP 865
SR SL S T +R G S R R+ QR+S S+ S ++ R
Sbjct: 702 SRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRS 761
Query: 866 SWSLSAKLQMRSNSPSRFSGDSPIHSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEP 925
S +K + R + SG SP S R+ SS +
Sbjct: 762 LSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRS--------------RSGSSQPKAK 807
Query: 926 SDSHSRREHKAVGRAPLAVMEGVFKDESDTRRLNSSVVDTQSKHSAQGDRLPPLSGPFDN 985
S + RR + P K ++ +R+ +SS S H PP G +
Sbjct: 808 SRTPPRRSRSSSSPPPKQ------KSKTPSRQSHSS----SSPHPKVKSGTPPRQGSITS 857
Query: 986 ---NNQIAYVDQSDSVDSSPVKEVKA--PSHPGSLAKKPESTTKRSPSSKGTSEPEKSLR 1040
N Q + +SSP E+K+ PS P +P + S
Sbjct: 858 PQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQP 917
Query: 1041 KGRPALASQESSLSSTSPSSPLPVKVSLKPSRSRSKADSSS-------RGSGRHSSPAPA 1093
K + ++ ++ S S +S SP V P RSRS + S+ R S SS
Sbjct: 918 KVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDT 977
Query: 1094 QPKKESSPKSQDSVS---------------------SPSPQKQKSASALTYTASSTSAKK 1132
+ K E+ P+ S S SP PQ +KS +L + + +
Sbjct: 978 KVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQ-EKSKDSLVQSCPGSLSLC 1036
Query: 1133 ASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPNSPRVSQARAGEGRGA 1192
A +S PPG+S SL +G Q+ R+ +S S S + + + +
Sbjct: 1037 AG---VKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTS 1093
Query: 1193 GKHVRSSSMASLRSPSTSIKSGLK-RDSKSEDKGLSFFKSALRQKETRRSTD 1243
K RS S SP T + S R + E KS + +++R +D
Sbjct: 1094 PKGGRSRS----SSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSD 1141
Score = 59.7 bits (143), Expect = 2e-08
Identities = 152/637 (23%), Positives = 215/637 (33%), Gaps = 95/637 (14%)
Query: 772 SANSSVAGSTSSSLCEHWVSRLPGSK--PASVTSAASSRRTSLA---SLSESVEMTGERS 826
S N S + H SR G PA+ S RT S S S + RS
Sbjct: 459 SKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRS 518
Query: 827 EDDGGFSTRPFVRSVQRQSLSSRSSVTSPLAVNENCMRPSWSLSAKLQMRSNSPSRFSGD 886
G S RS QR+ S SP RP WS S Q R S S G
Sbjct: 519 AQRWGRS-----RSPQRRGRSR-----SP-------QRPGWSRSRNTQRRGRSRSARRGR 561
Query: 887 SPIHSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSR-----REHKAVGRAP 941
S S A+ + R S S + P+ SR R ++ R P
Sbjct: 562 SHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRS-RTPTRRRSRSRTPARRGRSRSRTP 620
Query: 942 L-------AVMEGVFKDESDTRRLNSSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQ 994
+ + + S RR S T ++ R P G + +
Sbjct: 621 ARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGR 680
Query: 995 SDSVDSSPVKEVKAPSHPG-SLAKKPESTTKRSPS--SKGTSEPEKSLRKGRPALASQES 1051
S S + P+ G S ++ P RS S +G S R+GR +S+
Sbjct: 681 SRS---------RTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERK 731
Query: 1052 SLSSTSP------SSPLPVKVSLKPSRSRSKADSSSRGSGR--------HSSPAPAQ--- 1094
+ S TS SSP K + RSRS + S+ R SSP P Q
Sbjct: 732 NKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQ 791
Query: 1095 --PKKESSPKSQDSVSSPSPQKQKSASALTYTASSTSAKKASGPATRSPFPPGKSRTSDH 1152
P++ S SQ S +P ++ +S+ + ++ SP P KS T
Sbjct: 792 TPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPR 851
Query: 1153 S---LSREGSRQSLGSDRASA-TSTSKPNSPRVSQARAGEGRGAGKHVRSS-----SMAS 1203
S + + QS+ R S S+ P + +R + V+SS S +
Sbjct: 852 QGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSR 911
Query: 1204 LRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKET-RRSTDLG-----KTALLSKKAGGS 1257
SP +K+ + +S S S + + T RRS + ++ LL + +
Sbjct: 912 SSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSG 971
Query: 1258 SVKSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPASAKHSLLSARKSKSSQLD 1317
S K + + H S P K Q S S KSK S +
Sbjct: 972 SSSPDTKVKPETPPRQSHSGSISPYPKV----KAQTPPGPSLSGSKSPCPQEKSKDSLVQ 1027
Query: 1318 S---------GVPSS-PGGRQSAEKSSKKLSSSMQTS 1344
S GV SS P G SS +L QTS
Sbjct: 1028 SCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTS 1064
Score = 56.2 bits (134), Expect = 2e-07
Identities = 112/451 (24%), Positives = 160/451 (35%), Gaps = 61/451 (13%)
Query: 796 SKPASVTSAASSRRT-SLASLSESVEMTGERSEDDGGFSTRPFVRSVQRQSLSSRSSVTS 854
S P S SSRR+ SL+S + G S P +S Q SRS +
Sbjct: 745 SSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKS-QTPPRRSRSGSSQ 803
Query: 855 PLAVNENCMRPSWSLSAKL-QMRSNSPSRFSGDS-----------PIHSSASTLEKIGEA 902
P A + R S S S+ + +S +PSR S S P + T + E
Sbjct: 804 PKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQ 863
Query: 903 ADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVFKDESDTR------ 956
+ SCF S + + PS H G +P V +S +R
Sbjct: 864 SVTPQRRSCFESSPDPELKSRTPS------RHSCSGSSPPRVKSSTPPRQSPSRSSSPQP 917
Query: 957 RLNSSVVDTQSKHSAQGDRLPPLS------------GPFDNNNQIAYVDQSDSVDSSPVK 1004
++ + + Q HS P P N S S SSP
Sbjct: 918 KVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDT 977
Query: 1005 EVKAP-----SHPGSLAKKPE--STTKRSPSSKGTSEP------EKSLRKGRPALASQES 1051
+VK SH GS++ P+ + T PS G+ P + SL + P S +
Sbjct: 978 KVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCA 1037
Query: 1052 SLSSTSPSSPLPVKVSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPS 1111
+ S++P VS + +S+ R SSP Q ES S +SP
Sbjct: 1038 GVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDT--SSPEVRQSHSESPSLQSKSQTSPK 1095
Query: 1112 PQKQKSASALTYTASSTSAKKASG-----PATRSPFPPGKSRTSDHSLS--REGSRQSLG 1164
+ +S+S +T AS + ++ G P +S P +SR S S S LG
Sbjct: 1096 GGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLG 1155
Query: 1165 SDR-ASATSTSKPNSPRVSQARAGEGRGAGK 1194
R +A S K P A A R K
Sbjct: 1156 QSRLETAESKEKMALPPQEDATASPPRQKDK 1186
Score = 56.2 bits (134), Expect = 2e-07
Identities = 157/709 (22%), Positives = 257/709 (36%), Gaps = 121/709 (17%)
Query: 746 QLSEDEVCTQTAYILFYQRRTAIPSWSANSSVAGSTSSSLCEHWVSRLPGSKPASVTSAA 805
++ + + ++ + L R A S S++GS S C S+ P + S +S
Sbjct: 748 EMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGS---SPCPKQKSQTPPRRSRSGSSQP 804
Query: 806 SSR-----RTSLASLSESVEMTGERSEDDGGFSTRPFVRSVQRQSLSSRSSVTSPLAVNE 860
++ R S +S S + + S+ P + V+ + + S+TSP A NE
Sbjct: 805 KAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPK-VKSGTPPRQGSITSPQA-NE 862
Query: 861 NCMRPS----WSLSAKLQMRSNSPSRFS--GDSP--IHSSASTLEKIGEAADDKVSISCF 912
+ P + S +++S +PSR S G SP + SS + ++ + +
Sbjct: 863 QSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAI 922
Query: 913 GSLRNLS---SSYQEPSDSHSR---REHKAVGRAPLAVMEGVF----------------K 950
S R S SS PS SR R ++V +P + +E K
Sbjct: 923 ISPRQRSHSGSSSPSPSRVTSRTTPRRSRSV--SPCSNVESRLLPRYSHSGSSSPDTKVK 980
Query: 951 DESDTRRLNSSVVDTQSKHSAQGDRLPPLSG---PFDNNNQIAYVDQSDSVDSSPVKEVK 1007
E+ R+ +S + K AQ P LSG P + QS S VK
Sbjct: 981 PETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVK 1040
Query: 1008 APSHPG----------------------SLAKKPESTTKRSPSSKGTSEPEKSLRKGRPA 1045
+ + PG S PE S S S+ + S + GR
Sbjct: 1041 SSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSR 1100
Query: 1046 LASQESSLSSTSP---------SSPLPVKVSLKPSRSRSKADSSS--------------- 1081
+S + L+S SP +SP+ +K + P +SR ++DSSS
Sbjct: 1101 SSSPVTELASRSPIRQDRGEFSASPM-LKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRL 1159
Query: 1082 -RGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTY-----TASSTSAKKASG 1135
+ P Q +SP Q SP P + + S+L + T + S
Sbjct: 1160 ETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSS 1219
Query: 1136 PATRSPFPPGKSRTSDHSL------SREGSRQSLG--SDRASATSTSKPNSPRVSQARAG 1187
P T+ + + D L S E + Q L S STS S + R
Sbjct: 1220 PETKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPA 1279
Query: 1188 EGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQK------ETRRS 1241
+ +S+ ++ PS + G S E K LS S LR+ E R S
Sbjct: 1280 VSLTLDQSQSQASLEAVEVPSMASSWGGPHFS-PEHKELS--NSPLRENSFGSPLEFRNS 1336
Query: 1242 TDLGKTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPASA 1301
LG S VK ++ E P + + + P +
Sbjct: 1337 GPLGTE---MNTGFSSEVKEDLNGPFLNQLET--DPSLDMKEQSTRSSGHSSSELSPDAV 1391
Query: 1302 KHSLLSARKSKSSQLDSGVPSSPGGRQSAEKSSKKLSSSM-QTSARPSQ 1349
+ + +S+ +S SS + VP +P +S+ SS ++ + +T +R S+
Sbjct: 1392 EKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSR 1440
Score = 55.8 bits (133), Expect = 3e-07
Identities = 116/478 (24%), Positives = 182/478 (38%), Gaps = 64/478 (13%)
Query: 831 GFSTRPFVRSVQRQSLSSRSSVTSP-LAVNENCMRPSWSLSAKLQMRSNSPSRFSGDSPI 889
G + P ++ R RSS +SP L R S S S+ + RS +P R SP
Sbjct: 1671 GSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRR-SPS 1729
Query: 890 HSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVF 949
SS EK S R S+ + + SRR GR+P G+
Sbjct: 1730 VSSPEPAEKSR-------------SSRRRRSASSPRTKTTSRR-----GRSPSPKPRGLQ 1771
Query: 950 KDESDTRRL------------NSSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDS 997
+ S +RR +S + + S R+ + + Q S
Sbjct: 1772 RSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESS 1831
Query: 998 VDSSPVKEVKAPSHPGSLAKKPESTTKRSP--SSKGTSEPEKSLR-KGRPALASQESSLS 1054
SS + ++ + P S K+ S T +P S+ + P R + R L S+ S S
Sbjct: 1832 RTSSRRRRGRSRTPPTS-RKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRS 1890
Query: 1055 STSPSS--PLPVKVSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKS--QDSVSSP 1110
TSP S + S+ RSRS+A SR R +P + + S + + S S
Sbjct: 1891 RTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRT 1950
Query: 1111 SPQKQKSASALTYTASSTSAKKASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASA 1170
P ++ + + T + ++ + P TR +SRTS + R SR S + R S
Sbjct: 1951 PPVTRRRSRSRTPPVTRRRSRSRTSPITRR---RSRSRTSPVTRRRSRSRTSPVTRRRSR 2007
Query: 1171 TSTSKPNSPRVSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFK 1230
+ TS P + R S++R R+ + RS S S ++R S+S
Sbjct: 2008 SRTS-PVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRS-PLAIRRRSRSRTP------ 2059
Query: 1231 SALRQKETRRSTDLGKTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNANTT 1288
R +RS A+ + A GSS + R PPA++ + + T
Sbjct: 2060 ---RTARGKRSLTRSPPAIRRRSASGSS----------SDRSRSATPPATRNHSGSRT 2104
Score = 50.4 bits (119), Expect = 1e-05
Identities = 81/378 (21%), Positives = 145/378 (38%), Gaps = 51/378 (13%)
Query: 1012 PGSLAKKPEST-TKRSPSSKGTSEPEKS-------LRKGRPALASQESSLSS-------- 1055
P + A P S+ T ++P+S P + + R A A +SL+S
Sbjct: 2317 PPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALS 2376
Query: 1056 ----TSPSSPLPV--KVSLKPS-----RSRSKADSSSRGSGRHSS---PAPAQ-----PK 1096
TSP PL +VS + S R+RS+ S+ R +S P+P+ P
Sbjct: 2377 GANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPS 2436
Query: 1097 KESSPKSQDSVSSPSPQ--KQKSASALTYTASSTSAKKASGPATRSPFPPGKSRTSDHSL 1154
+ P +QD SP P +S + T ++ S A + S+
Sbjct: 2437 QSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSV 2496
Query: 1155 SREGSRQSLGSDRASATSTSKPNSPRVSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSG 1214
G S + ++T +P++ ++ + + R + SSS +S S S+S S
Sbjct: 2497 PAPGVPHSDVGEPPASTGAQQPSA--LAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSS 2554
Query: 1215 LKRDSKSEDKGLSF-FKSALRQKETRRSTDLGKTALLSKKAGGSSVKSVCKNTGDDEAER 1273
S S+ +G S + + K T K A+ + + A+R
Sbjct: 2555 SSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPT-----------PAKR 2603
Query: 1274 GHQPPASQQPNANTTGKEQLVTKDPASAKHSLLSARKSKSSQLDSGVPSSPGGRQSAEKS 1333
+ +S +++++ + +S+ S S+ S SS S P+ PG + + +
Sbjct: 2604 KRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPA 2663
Query: 1334 SKKLSSSMQTSARPSQKP 1351
S K + +R +KP
Sbjct: 2664 SPKKPPPGERRSRSPRKP 2681
Score = 48.1 bits (113), Expect = 6e-05
Identities = 93/386 (24%), Positives = 142/386 (36%), Gaps = 66/386 (17%)
Query: 772 SANSSVAGSTSSSLCEHWVSRLPGSKPASVTSAASSRRTSLASLSESVEMTGERSED--- 828
SA V+G TS L + SR P S P+ SR TS + S S M S+
Sbjct: 2388 SAYERVSGRTSPPLLDRARSRTPPSAPSQ------SRMTSERAPSPSSRMGQAPSQSLLP 2441
Query: 829 ---DGGFSTRPFVRSVQRQSLSSRSSVTSPLAVNENCMRPSWSLSAKLQMRSNS------ 879
D S P S Q + L ++ T+P+A +++ + + + N
Sbjct: 2442 PAQDQPRSPVPSAFSDQSRCLIAQ---TTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPA 2498
Query: 880 ---PSRFSGDSPIHSSA---STLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSR-- 931
P G+ P + A S L + A + + S S S + SSS S S S
Sbjct: 2499 PGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGS 2558
Query: 932 ------------REHKAVGRAPL-------AVMEGVFKDESDTRRLNSSVVDTQSKHSAQ 972
+ A+ R P AV EG + + +R S + S S+
Sbjct: 2559 SSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSS 2618
Query: 973 GDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSHPGSLA-KKPESTTKRSPSSKG 1031
S +++ + S S SS +P+ PG A KP S K P +
Sbjct: 2619 SSS----SSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERR 2674
Query: 1032 TSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKPSRSRSKADSSSRGS-----GR 1086
+ P K + R + + S + PS +PS ++ SS RGS G
Sbjct: 2675 SRSPRKPIDSLRDSRSLSYSPVERRRPSP--------QPSPRDQQSSSSERGSRRGQRGD 2726
Query: 1087 HSSPAPAQPKKESSPKSQDSVSSPSP 1112
SP+ + ++ SP+ SS SP
Sbjct: 2727 SRSPSHKRRRETPSPRPMRHRSSRSP 2752
Score = 44.7 bits (104), Expect = 6e-04
Identities = 46/181 (25%), Positives = 74/181 (40%), Gaps = 5/181 (2%)
Query: 1054 SSTSPSSPLPVKVSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESS-PKSQDSVSSPSP 1112
+ST P + +L+P++ R + SSS S SS + + SS S DS S P
Sbjct: 2511 ASTGAQQPSAL-AALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLP 2569
Query: 1113 QKQKSASALTYTASSTSAKKASGPATRSPFP-PGKSRTSDHSLSREGSRQSLGSDRASAT 1171
+ + AL S T A K + R P P P K + S S S S S +S++
Sbjct: 2570 VQPE--VALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSS 2627
Query: 1172 STSKPNSPRVSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKS 1231
S+S +S S + + + + A + S +R S+S K + +
Sbjct: 2628 SSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRD 2687
Query: 1232 A 1232
+
Sbjct: 2688 S 2688
Score = 43.9 bits (102), Expect = 0.001
Identities = 71/297 (23%), Positives = 117/297 (39%), Gaps = 23/297 (7%)
Query: 745 QQLSEDEVCTQTAYILFYQRRTAIPSWSANSSVAGSTSSSLCEHWVSRLPGSKPA----- 799
Q LS V T T+ + ++P+ S G +S S L +PA
Sbjct: 2473 QSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRS 2532
Query: 800 -SVTSAASSRRTSLASLSESVEMTGERSEDDGGFSTRPFVRSVQRQSLSSRSSVTSPLAV 858
S +S++SS +S +S S S +G S D G S+ P V + + S + AV
Sbjct: 2533 SSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEG-SSLPVQPEVALKRVPSPTPAPKE-AV 2590
Query: 859 NENCMRPSWSLSAKLQMRSNSPSRFSGDSPIHSSASTLEKIGEAADDKVSISCFGSLRNL 918
E RP AK + RS+S S S S SS+S+ ++ S S S +
Sbjct: 2591 REG--RPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSS------SSSSSSSSSSSSSSSSS 2642
Query: 919 SSSYQEPSDSHSRREHKAVGRAPLAVMEGVFKDESDTRRLNSSVVDTQSKHSAQGDRLPP 978
SSS PS + + +P G + S + ++ S+ D++S + +R P
Sbjct: 2643 SSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPID-SLRDSRSLSYSPVERRRP 2701
Query: 979 LSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSHPGSLAKKPESTTKRSPSSKGTSEP 1035
P + QS S + + + S S ++ E+ + R + + P
Sbjct: 2702 SPQPSPRD------QQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSSRSP 2752
Score = 37.4 bits (85), Expect = 0.098
Identities = 50/227 (22%), Positives = 86/227 (37%), Gaps = 28/227 (12%)
Query: 955 TRRLNSSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSHPGS 1014
TRR + S T + S R PP++ + + +SP+ ++ S
Sbjct: 1931 TRRRSRSRTPTTRRRSRS--RTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSP 1988
Query: 1015 LAKKPES------TTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPS------SPL 1062
+ ++ T +RS S +S + PA+ + S + P SPL
Sbjct: 1989 VTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPL 2048
Query: 1063 PVKVSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSP--QKQKSASA 1120
++ RSRS+ ++RG + PA ++ +S S D S +P + S S
Sbjct: 2049 AIR-----RRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSR 2103
Query: 1121 LTYTASSTSAKKASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDR 1167
A ++S + SP P + R+ G + LGS R
Sbjct: 2104 TPPVALNSSRMSCFSRPSMSPTPLDRCRS-------PGMLEPLGSSR 2143
Score = 33.9 bits (76), Expect = 1.1
Identities = 26/70 (37%), Positives = 34/70 (48%), Gaps = 8/70 (11%)
Query: 43 ASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGLRSCFPPGPAAAP 102
+S ++ SS SS SS+ S S S + S+ S SS ++P S PGP A P
Sbjct: 2607 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSP------SPAKPGPQALP 2660
Query: 103 TP--PPCPPP 110
P P PPP
Sbjct: 2661 KPASPKKPPP 2670
Score = 31.2 bits (69), Expect = 7.1
Identities = 33/136 (24%), Positives = 51/136 (37%), Gaps = 17/136 (12%)
Query: 39 GGPGASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGLRSCFPPGP 98
G P PA SS SS+ S S S + S+ S SS ++
Sbjct: 2593 GRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS--------- 2643
Query: 99 AAAPTPPPCPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLAL 158
+++ +P P P P + PA +P PG R+ + LS + +
Sbjct: 2644 SSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPV------- 2696
Query: 159 GQYRAGRPEPSPDPEQ 174
+ R P+PSP +Q
Sbjct: 2697 -ERRRPSPQPSPRDQQ 2711
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.127 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,943,949
Number of Sequences: 37866
Number of extensions: 3361632
Number of successful extensions: 52133
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 634
Number of HSP's successfully gapped in prelim test: 1925
Number of HSP's that attempted gapping in prelim test: 25387
Number of HSP's gapped (non-prelim): 19017
length of query: 1352
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1238
effective length of database: 13,930,794
effective search space: 17246322972
effective search space used: 17246322972
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.