Search of human proteins with 24497499

Search of human proteins with 24497499

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
         (542 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24497499 solute carrier family 22 member 8 [Homo sapiens]         1093   0.0  
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   543   e-154
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   538   e-153
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       488   e-138
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   481   e-136
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   476   e-134
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          430   e-120
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          415   e-116
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]       378   e-105
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]       378   e-105
gi|42542386 solute carrier family 22 (organic anion/cation trans...   360   1e-99
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   353   2e-97
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   348   5e-96
gi|153791484 putative UST1-like organic anion transporter [Homo ...   343   3e-94
gi|166064021 solute carrier family 22 (organic anion transporter...   320   2e-87
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           281   1e-75
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   277   2e-74
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          272   5e-73
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          261   2e-69
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           256   4e-68
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          239   5e-63
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   236   3e-62
gi|157426885 organic cation transporter like 4 [Homo sapiens]         235   9e-62
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        226   4e-59
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       212   6e-55
gi|24308167 SV2 related protein [Homo sapiens]                        142   6e-34
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...   137   2e-32
gi|170650643 solute carrier family 22, member 23 isoform a [Homo...   135   7e-32
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6...   132   8e-31
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   125   8e-29

>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score = 1093 bits (2827), Expect = 0.0
 Identities = 542/542 (100%), Positives = 542/542 (100%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW 60
           MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW
Sbjct: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW 60

Query: 61  VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK 120
           VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK
Sbjct: 61  VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK 120

Query: 121 LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR 180
           LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR
Sbjct: 121 LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR 180

Query: 181 FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL 240
           FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL
Sbjct: 181 FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL 240

Query: 241 TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN 300
           TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN
Sbjct: 241 TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN 300

Query: 301 LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI 360
           LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI
Sbjct: 301 LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI 360

Query: 361 IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG 420
           IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG
Sbjct: 361 IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG 420

Query: 421 CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI 480
           CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI
Sbjct: 421 CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI 480

Query: 481 TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG 540
           TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG
Sbjct: 481 TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG 540

Query: 541 SS 542
           SS
Sbjct: 541 SS 542


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  543 bits (1398), Expect = e-154
 Identities = 278/547 (50%), Positives = 372/547 (68%), Gaps = 20/547 (3%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP- 59
           M F+++L +VG +G FQ + V ++ LP+L MA+HN LQ FTAA P HHCRPP +A+    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60

Query: 60  -----WVLPMGPNGKPERCLRFVHPP------NASLPNDTQRAMEPCLDGWVY-NSTKDS 107
                W LP    G+PE CLRF  P       N +  N T  A EPC DGW+Y NST  S
Sbjct: 61  GGLEVW-LPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTG-ATEPCTDGWIYDNSTFPS 118

Query: 108 -IVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSG 166
            IVTEWDLVC+   L+++AQS++M G+L+G +V G L+DR GRR +L  +YL  A SG+ 
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 167 AAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILP 226
           AAF+P FPIY  FR L G  ++GI+L+ + LNVEW+P   RA + T +GY Y+ GQF+L 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 227 GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK 286
           G+AYA+P WR LQL VS PFF FF+ SW+  ES RW   SG+    L+ L+RVA  NGK+
Sbjct: 239 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR 298

Query: 287 EEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAM 346
           EEG +LS+E L+ +LQKE+++ K + +A +L R P LR +  CLS+ WFAT FAYY L M
Sbjct: 299 EEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM 358

Query: 347 GVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLD 406
            ++ FGV++Y++Q+IFG VD+PAK +  L ++ LGR   Q AALLLAG  IL    +P D
Sbjct: 359 DLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQD 418

Query: 407 LQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKIT 466
              VRT LAV GKGCL++SF+C+FLYT ELYPT+IRQTGMG+ +   RVGS+VSPLV +T
Sbjct: 419 QSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMT 478

Query: 467 GEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKA 526
            E+ P +P  IYG   +   +  + LPETL QPLP+T++DLE  S + K+ +Q+ E +K 
Sbjct: 479 AELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLE--SRKGKQTRQQQEHQK- 535

Query: 527 SQRIPLQ 533
              +PLQ
Sbjct: 536 -YMVPLQ 541


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  538 bits (1387), Expect = e-153
 Identities = 277/558 (49%), Positives = 373/558 (66%), Gaps = 29/558 (5%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP- 59
           M F+++L +VG +G FQ + V ++ LP+L MA+HN LQ FTAA P HHCRPP +A+    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60

Query: 60  -----WVLPMGPNGKPERCLRFVHPP------NASLPNDTQRAMEPCLDGWVY-NSTKDS 107
                W LP    G+PE CLRF  P       N +  N T  A EPC DGW+Y NST  S
Sbjct: 61  GGLEVW-LPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTG-ATEPCTDGWIYDNSTFPS 118

Query: 108 -IVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSG 166
            IVTEWDLVC+   L+++AQS++M G+L+G +V G L+DR GRR +L  +YL  A SG+ 
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 167 AAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILP 226
           AAF+P FPIY  FR L G  ++GI+L+ + LNVEW+P   RA + T +GY Y+ GQF+L 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 227 GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK 286
           G+AYA+P WR LQL VS PFF FF+ SW+  ES RW   SG+    L+ L+RVA  NGK+
Sbjct: 239 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR 298

Query: 287 EEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAM 346
           EEG +LS+E L+ +LQKE+++ K + +A +L R P LR +  CLS+ WFAT FAYY L M
Sbjct: 299 EEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM 358

Query: 347 GVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLD 406
            ++ FGV++Y++Q+IFG VD+PAK +  L ++ LGR   Q AALLLAG  IL    +P D
Sbjct: 359 DLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQD 418

Query: 407 LQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKIT 466
              VRT LAV GKGCL++SF+C+FLYT ELYPT+IRQTGMG+ +   RVGS+VSPLV +T
Sbjct: 419 QSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMT 478

Query: 467 GEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLEN-----------WSLRAK 515
            E+ P +P  IYG   +   +  + LPETL QPLP+T++DLE+           +  + K
Sbjct: 479 AELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGK 538

Query: 516 KPKQEPEVEKASQRIPLQ 533
           + +Q+ E +K    +PLQ
Sbjct: 539 QTRQQQEHQK--YMVPLQ 554


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  488 bits (1255), Expect = e-138
 Identities = 258/550 (46%), Positives = 346/550 (62%), Gaps = 23/550 (4%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHN---AST 57
           M F+++LD +GSMG FQ  H A+L LP   +A HN LQ FTAA P HHCR P N   AST
Sbjct: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST 60

Query: 58  ---GPWV---LPMGPNGKPERCLRFVHP------PNASLPNDTQRAMEPCLDGWVYNST- 104
              G W+   +P+   G PE C RF  P      PN+S+P     A E C DGWVYN + 
Sbjct: 61  NDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPG---AATEGCKDGWVYNRSV 117

Query: 105 -KDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAAS 163
              +IV EWDLVC +  L+++AQS++MAG+L+G  V G L+DR G +  L  SYL LAAS
Sbjct: 118 FPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAAS 177

Query: 164 GSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQF 223
           G+  A+  +F  Y VFRFL G   SGI L++V L VEW+PTR R +    LGY +T GQ 
Sbjct: 178 GAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQL 237

Query: 224 ILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFN 283
           IL G+AY I  WR LQ  +S PF +FFL SWW PES RWL+L GKS  A++ L++VA  N
Sbjct: 238 ILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMN 297

Query: 284 GKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYS 343
           G+KEEGERL+ E +   +Q E +      +  DLFR P +R++T CL + WF+   AYY 
Sbjct: 298 GRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYG 357

Query: 344 LAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFV 403
           LAM +++FG++LY++Q +FG ++ PA  +   ++ Y+GR  T A+ L+LAG  ++A  FV
Sbjct: 358 LAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFV 417

Query: 404 PLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLV 463
           P   Q + T  A  GKGCL+SSF C++L+T ELYPT IRQ GMG +++  R+G + +PLV
Sbjct: 418 PEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLV 477

Query: 464 KITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEV 523
              GE    +P + +G TA+L G A   L ET N PL ETI  +E    R K+   +  V
Sbjct: 478 TTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMER---RVKEGSSKKHV 534

Query: 524 EKASQRIPLQ 533
           E+ S+ I LQ
Sbjct: 535 EEKSEEISLQ 544


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  481 bits (1237), Expect = e-136
 Identities = 257/547 (46%), Positives = 344/547 (62%), Gaps = 64/547 (11%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP- 59
           M F+++L +VG +G FQ + V ++ LP+L MA+HN LQ FTAA P HHCRPP +A+    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60

Query: 60  -----WVLPMGPNGKPERCLRFVHPP------NASLPNDTQRAMEPCLDGWVY-NSTKDS 107
                W LP    G+PE CLRF  P       N +  N T  A EPC DGW+Y NST  S
Sbjct: 61  GGLEVW-LPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTG-ATEPCTDGWIYDNSTFPS 118

Query: 108 -IVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSG 166
            IVTEWDLVC+   L+++AQS++M G+L+G +V G L+DR GRR +L  +YL  A SG+ 
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 167 AAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILP 226
           AAF+P FPIY  FR L G  ++GI+L+ + LNVEW+P   RA + T +GY Y+ GQF+L 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 227 GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK 286
           G+AYA+P WR LQL VS PFF FF+ SW+  ES RW   SG+    L+ L+RVA  NGK+
Sbjct: 239 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR 298

Query: 287 EEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAM 346
           EEG +LS+E L+ +LQKE+++ K + +A +L R P LR +  CLS+ WFAT FAYY L M
Sbjct: 299 EEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM 358

Query: 347 GVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLD 406
            ++ FGV++Y++Q+IFG VD+PAK +  L ++ LGR   Q AALLLAG  IL    +P D
Sbjct: 359 DLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQD 418

Query: 407 LQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKIT 466
              VRT LAV GKGCL++SF+C+FLYT ELYPT+IR                        
Sbjct: 419 QSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR------------------------ 454

Query: 467 GEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKA 526
                               +  + LPETL QPLP+T++DLE  S + K+ +Q+ E +K 
Sbjct: 455 --------------------AVTVLLPETLGQPLPDTVQDLE--SRKGKQTRQQQEHQK- 491

Query: 527 SQRIPLQ 533
              +PLQ
Sbjct: 492 -YMVPLQ 497


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  476 bits (1226), Expect = e-134
 Identities = 256/558 (45%), Positives = 345/558 (61%), Gaps = 73/558 (13%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP- 59
           M F+++L +VG +G FQ + V ++ LP+L MA+HN LQ FTAA P HHCRPP +A+    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60

Query: 60  -----WVLPMGPNGKPERCLRFVHPP------NASLPNDTQRAMEPCLDGWVY-NSTKDS 107
                W LP    G+PE CLRF  P       N +  N T  A EPC DGW+Y NST  S
Sbjct: 61  GGLEVW-LPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTG-ATEPCTDGWIYDNSTFPS 118

Query: 108 -IVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSG 166
            IVTEWDLVC+   L+++AQS++M G+L+G +V G L+DR GRR +L  +YL  A SG+ 
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 167 AAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILP 226
           AAF+P FPIY  FR L G  ++GI+L+ + LNVEW+P   RA + T +GY Y+ GQF+L 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 227 GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK 286
           G+AYA+P WR LQL VS PFF FF+ SW+  ES RW   SG+    L+ L+RVA  NGK+
Sbjct: 239 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR 298

Query: 287 EEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAM 346
           EEG +LS+E L+ +LQKE+++ K + +A +L R P LR +  CLS+ WFAT FAYY L M
Sbjct: 299 EEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM 358

Query: 347 GVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLD 406
            ++ FGV++Y++Q+IFG VD+PAK +  L ++ LGR   Q AALLLAG  IL    +P D
Sbjct: 359 DLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQD 418

Query: 407 LQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKIT 466
              VRT LAV GKGCL++SF+C+FLYT ELYPT+IR                        
Sbjct: 419 QSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR------------------------ 454

Query: 467 GEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLEN-----------WSLRAK 515
                               +  + LPETL QPLP+T++DLE+           +  + K
Sbjct: 455 --------------------AVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGK 494

Query: 516 KPKQEPEVEKASQRIPLQ 533
           + +Q+ E +K    +PLQ
Sbjct: 495 QTRQQQEHQK--YMVPLQ 510


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  430 bits (1105), Expect = e-120
 Identities = 223/536 (41%), Positives = 335/536 (62%), Gaps = 23/536 (4%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPP--HNASTG 58
           M FSE+LD VG +G FQ L    L + I+ +   ++L+ F+AA P H C  P   N++  
Sbjct: 1   MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60

Query: 59  PWVL-------------PMGPNGKPERCLRFVHP------PNASLPNDTQRAMEPCLDGW 99
             +L             P GPN +P +C RF  P      PNA+  + ++   EPC+DGW
Sbjct: 61  ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120

Query: 100 VYNST--KDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSY 157
           VY+ +    +IV +W+LVC+S+ LK MAQSI++AGIL+G    G  SDRFGRR +LT SY
Sbjct: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180

Query: 158 LLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC 217
           L +A  G+ AAF+P FP+Y +FRFL  F ++G+ ++T  L +EW   R R ++ T     
Sbjct: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240

Query: 218 YTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILR 277
           ++FG  +   +AY +  W  LQL VS+PFF+ FL SWW  ES RWL+ +G+    L+ L 
Sbjct: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300

Query: 278 RVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFAT 337
           RVA  NGK    + L+ E L   +++E+S+ +   +   L R+P LR  T   +L WFA 
Sbjct: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360

Query: 338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAI 397
           GF ++ LA+ ++  G N+++LQ+  G VD+PAK   +L LS+LGR  T AA+LLLAG  I
Sbjct: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420

Query: 398 LALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGS 457
           LA T VP ++  +R+ LAV G G + ++F+C+ +Y+SEL+PTV+R T +G+  +  R G+
Sbjct: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480

Query: 458 MVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLR 513
           ++ PLV++ G   P++P ++YG   +L G AAL LPET + PLP+TI+D++N +++
Sbjct: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVK 536


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  415 bits (1067), Expect = e-116
 Identities = 226/545 (41%), Positives = 330/545 (60%), Gaps = 24/545 (4%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW 60
           M FS++L++ G +G FQ L V    LP L + +  LL+ F+AA P H C   H    G  
Sbjct: 1   MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWT-HMLDNGSA 59

Query: 61  V-------------LPMGPNGKPERCLRFVHP------PNASLPNDTQRAMEPCLDGWVY 101
           V             +P GPN  P +C RF  P      PNA+  + ++   EPC+DGWVY
Sbjct: 60  VSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVY 119

Query: 102 NST--KDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLL 159
           + +    +IV +WDLVC+S  LK ++QSIFM+GIL+G  + G LS RFGR+P+L+   L 
Sbjct: 120 DRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQ 179

Query: 160 LAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYT 219
           LA +G+   F+PTF IY   RF+  FG++GI LS++ L VEW  T  RA+  T +G  ++
Sbjct: 180 LAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFS 239

Query: 220 FGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRV 279
            GQ  L GLA+A+  WR LQL  S+PFF   L SWW PES RWL++ GK  +AL+ LR+V
Sbjct: 240 AGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKV 299

Query: 280 AVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGF 339
           A  NG K E + L++E L  ++++E++ AK   +  DLF +P+LR  +  + +  F+   
Sbjct: 300 ARINGHK-EAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLI 358

Query: 340 AYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILA 399
           +YY L   ++  G ++++LQ +FG VD   +  T L LS+LGR T QA +  +AG AILA
Sbjct: 359 SYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILA 418

Query: 400 LTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMV 459
              VP DLQT+R V AV GKGC   S +CL +Y +EL+PT +R T  G+ +   R+G+M+
Sbjct: 419 NMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMM 478

Query: 460 SPLVKITGEVQPFIPNIIYGITALLGGSAAL-FLPETLNQPLPETIEDLENWSLRAKKPK 518
            PL+ ++ +  P +P ++YG+ ++      L FLPET   PLP+TI+DLE+    A +  
Sbjct: 479 GPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQKSTAAQGN 538

Query: 519 QEPEV 523
           ++  V
Sbjct: 539 RQEAV 543


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score =  378 bits (971), Expect = e-105
 Identities = 203/539 (37%), Positives = 311/539 (57%), Gaps = 23/539 (4%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHC---RPPHNAST 57
           M F E+L +VG +G FQ LH+  +   ++ +  H LL+ F AA P H C      +N  +
Sbjct: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60

Query: 58  GPWV------------LPMGPNGKPERCLRFVHPP------NASLPNDTQRAMEPCLDGW 99
           G               +P+  N +PE+C RFVHP       N ++ + ++   EPC+DGW
Sbjct: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120

Query: 100 VYNST--KDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSY 157
           VY+ +    +IVT+WDLVC+   LK + Q + + G+L+GG++ G +SDRFGRR IL    
Sbjct: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180

Query: 158 LLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC 217
           L LA + + AAF+PTFP+Y V RFL GF    I  +  +   EW+    +A++       
Sbjct: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240

Query: 218 YTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILR 277
            + GQ IL GLAY    W+ L +  S+PFFVFFL S W  ES RWL+++ K  + LK LR
Sbjct: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300

Query: 278 RVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFAT 337
           +VA  NG K   E L++E ++  +Q+E+  A+ K T  DLFR P +R+    L    FA 
Sbjct: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360

Query: 338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAI 397
              +Y   + ++  G N+++LQ+++G V +  + + +L+L+++GR  +Q   + L G +I
Sbjct: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420

Query: 398 LALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGS 457
           LA TFVP ++QT+R  LA  G GC +++FS + ++  EL PTV+R    G+    +R+G+
Sbjct: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480

Query: 458 MVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKK 516
            ++PL+         +P IIYGI  ++GG     LPET N PLP+TI+D+EN     K+
Sbjct: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKE 539


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score =  378 bits (970), Expect = e-105
 Identities = 215/551 (39%), Positives = 312/551 (56%), Gaps = 24/551 (4%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPP-------H 53
           M F  +LD+VG MG FQ   +A   +  + +  + +L+ FTA TP H C  P        
Sbjct: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60

Query: 54  NASTGPWV--------LPMGPNGKPERCLRFVHPP------NASLPNDTQRAMEPCLDGW 99
           +  TG           +P+  N +P++C RF+HP       N + PN  +   EPC+DGW
Sbjct: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120

Query: 100 VYNSTK--DSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSY 157
           VY+ +    +IVTEWDLVC S  LK M QS+FMAG L+GGL+ G LSDR GR+ I    +
Sbjct: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180

Query: 158 LLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC 217
           L LA S + AAF+PTF +Y + RFL GF    I  +T IL++EW   R R++    L   
Sbjct: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240

Query: 218 YTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILR 277
           Y+ GQ +L GLA+AI  W  LQLTVS P  V FLSSW   ES RWL+++ +  + LK LR
Sbjct: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300

Query: 278 RVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFAT 337
           RVA  NGKK   E L+ E ++  ++KE+   + K +   LFR P LR   F L    FA 
Sbjct: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360

Query: 338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAI 397
              +Y L + ++  G N+ + QI+ G V   A+ +++L+L+++GR  +Q       G  I
Sbjct: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420

Query: 398 LALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGS 457
           L  TF+P ++Q +R VLA  G G +S++ +   ++ +EL PT++R T  G++ +  R G+
Sbjct: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480

Query: 458 MVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKP 517
            ++PL+       P +P I YG+  +L     L LPET + PLP TI+D+EN    ++  
Sbjct: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVEN-EKDSRNI 539

Query: 518 KQEPEVEKASQ 528
           KQE    K +Q
Sbjct: 540 KQEDTCMKVTQ 550


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score =  360 bits (925), Expect = 1e-99
 Identities = 210/550 (38%), Positives = 309/550 (56%), Gaps = 27/550 (4%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHC-------RPPH 53
           M F ++L   G +  FQ L    L +  +    H +L+ FTA  P H C           
Sbjct: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60

Query: 54  NASTGPWV--------LPMGPNGKPERCLRFVHPP------NASLPNDTQRAMEPCLDGW 99
           +  TG           +P+  N +PE+C RFVHP       N + PN +   MEPC+DGW
Sbjct: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120

Query: 100 VYN--STKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSY 157
           VY+  S   +IVTEWDLVC+S  L  +A+ +FMAG+++GG++ G LSDRFGRR +L   Y
Sbjct: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180

Query: 158 LLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC 217
           L +A  G+ AA +PTF IY   RFL G     +  +T++L  EW   R +A M   LG C
Sbjct: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQA-MGITLGMC 239

Query: 218 YTFGQFI-LPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKIL 276
            +   F+ L GLA+AI  W  LQL VS+P+FV FL+S W  ES RWL+++ K  + LK L
Sbjct: 240 PSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299

Query: 277 RRVAVFNGKKEEGERLSLEELKLNLQKEISLA-KAKYTASDLFRIPMLRRMTFCLSLAWF 335
           R+ A  +G K   + L+LE LK  ++KE+  A K K +  ++  +P + +    LS   F
Sbjct: 300 RKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRF 359

Query: 336 ATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGG 395
           A   AY+ L + V+  G N+++LQ +FG V + A  +   +L Y+ R  +Q   + L   
Sbjct: 360 ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAI 419

Query: 396 AILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRV 455
            +LA+ FVP ++QT+R VLA  G G  + + +  F + +E+ PT+IR   MG++  +  +
Sbjct: 420 CLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANI 479

Query: 456 GSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAK 515
              ++PL+ I     P +P IIYG+   + G A L LPET N+PL +TI+D +N     +
Sbjct: 480 AGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPR 539

Query: 516 KPKQE-PEVE 524
           +PKQE P VE
Sbjct: 540 EPKQEDPRVE 549


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  353 bits (907), Expect = 2e-97
 Identities = 203/540 (37%), Positives = 289/540 (53%), Gaps = 22/540 (4%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR----PPHNAS 56
           M F E+L++VG  G FQ  +VA+L LP + +  H LL IF AA P H C     P + + 
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60

Query: 57  TGPWV---LPMGPNGKPERCLRFVHP---PNASLPNDTQRAME--------PCLDGWVYN 102
              W+   LP  P+G    CLRF +P   PN +L  + Q   E        PC  GW Y+
Sbjct: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120

Query: 103 STKDS--IVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLL 160
            ++ S  I TEWDLVC    L   A + F AG+L+G +  G LSDRFGRR +L  +Y+  
Sbjct: 121 HSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVST 180

Query: 161 AASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTF 220
              G  +A S ++ ++ + R L G  ++G T+  + L +EW+    R +        +T 
Sbjct: 181 LVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTG 240

Query: 221 GQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVA 280
           G  +L  + Y I  WRWL L V++P     LS WW PES RWL+  G   +A + L   A
Sbjct: 241 GVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCA 300

Query: 281 VFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFA 340
             NG+    +  S E +      E  + +  Y   DLFR P LR ++ C  + WF   F+
Sbjct: 301 RLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYL--DLFRTPRLRHISLCCVVVWFGVNFS 358

Query: 341 YYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILAL 400
           YY L++ V   G+N+Y  Q++FG V++P+K +  LS+ Y GR  TQA  LL    A    
Sbjct: 359 YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR 418

Query: 401 TFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVS 460
             V  D+++  TVLAV GK    ++F+  +L+TSELYPTV+RQTGMG++ L  R+G  ++
Sbjct: 419 LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA 478

Query: 461 PLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQE 520
           PL  +   V   +P + YG  ALL    AL LPET    LPETI+D+E  S      ++E
Sbjct: 479 PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEE 538


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  348 bits (894), Expect = 5e-96
 Identities = 203/542 (37%), Positives = 289/542 (53%), Gaps = 24/542 (4%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR----PPHNAS 56
           M F E+L++VG  G FQ  +VA+L LP + +  H LL IF AA P H C     P + + 
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60

Query: 57  TGPWV---LPMGPNGKPERCLRFVHP---PNASLPNDTQRAME--------PCLDGWVYN 102
              W+   LP  P+G    CLRF +P   PN +L  + Q   E        PC  GW Y+
Sbjct: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120

Query: 103 STKDS--IVTE--WDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYL 158
            ++ S  I TE  WDLVC    L   A + F AG+L+G +  G LSDRFGRR +L  +Y+
Sbjct: 121 HSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV 180

Query: 159 LLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCY 218
                G  +A S ++ ++ + R L G  ++G T+  + L +EW+    R +        +
Sbjct: 181 STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW 240

Query: 219 TFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRR 278
           T G  +L  + Y I  WRWL L V++P     LS WW PES RWL+  G   +A + L  
Sbjct: 241 TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH 300

Query: 279 VAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATG 338
            A  NG+    +  S E +      E  + +  Y   DLFR P LR ++ C  + WF   
Sbjct: 301 CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYL--DLFRTPRLRHISLCCVVVWFGVN 358

Query: 339 FAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAIL 398
           F+YY L++ V   G+N+Y  Q++FG V++P+K +  LS+ Y GR  TQA  LL    A  
Sbjct: 359 FSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFG 418

Query: 399 ALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSM 458
               V  D+++  TVLAV GK    ++F+  +L+TSELYPTV+RQTGMG++ L  R+G  
Sbjct: 419 TRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGS 478

Query: 459 VSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPK 518
           ++PL  +   V   +P + YG  ALL    AL LPET    LPETI+D+E  S      +
Sbjct: 479 LAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQE 538

Query: 519 QE 520
           +E
Sbjct: 539 EE 540


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  343 bits (879), Expect = 3e-94
 Identities = 196/546 (35%), Positives = 300/546 (54%), Gaps = 23/546 (4%)

Query: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHC----------- 49
           M F ++LD+VG +G FQ L +  L +  + + +   L+ F A    H C           
Sbjct: 1   MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60

Query: 50  -RPPHNASTGPWV---LPMGPNGKPERCLRFVHPP------NASLPNDTQRAMEPCLDGW 99
              P   S    +   +P   N +PE+C RFVHP       N + PN ++   EPC+DGW
Sbjct: 61  DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120

Query: 100 VYNSTK--DSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSY 157
           VY+ +    +IVT+WDLVC S  L  +A+ +FMAG+++GG + G LSDRFGR+ +L  SY
Sbjct: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180

Query: 158 LLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC 217
           L LA  G+ AAF+PT  +Y   RFL G     I ++TV+L VEW+  +  A+  T     
Sbjct: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240

Query: 218 YTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILR 277
            + G   L  LA+ I     LQL +S P FVFFL S W  ES RWL+++ K  + LK LR
Sbjct: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300

Query: 278 RVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFAT 337
           + A  NG K   + L++E LK  +++E+  A+ K++  +L RIP + +    LS   FA+
Sbjct: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360

Query: 338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAI 397
              ++ L + ++  G N+++LQ +FG V + A  +   +L+++ R  +Q   + L    +
Sbjct: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420

Query: 398 LALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGS 457
           LA+ FVP ++QT+R VLA  G G  S   +C     +EL P++IR    G++  +  +G 
Sbjct: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480

Query: 458 MVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKP 517
            ++ L+ I       +P IIYG+ A+L G   L LPET NQPL ++I+D+EN  + +   
Sbjct: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGVNSLAA 540

Query: 518 KQEPEV 523
            Q   V
Sbjct: 541 PQRSSV 546


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  320 bits (821), Expect = 2e-87
 Identities = 190/548 (34%), Positives = 292/548 (53%), Gaps = 37/548 (6%)

Query: 3   FSEILDRVGSMGHFQFLHVAILGLPILNMAN--HNLLQIFTAATPVHHC------RPPHN 54
           F ++L  +G  G FQ + + IL L +LN  +  +    +F      HHC          N
Sbjct: 4   FVQVLAEIGDFGRFQ-IQLLIL-LCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFN 61

Query: 55  ASTGPWVL---PMGPNGKPERCLRFVHPP-NASLP-------NDTQRAMEPCLDGWVYNS 103
            S    ++   P+   G PE CL F  PP NASL        N+TQ    PC  GW Y  
Sbjct: 62  LSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQ----PCDMGWEYPE 117

Query: 104 TK-DSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAA 162
            +  S+  E++LVC+   LK+  QS+FMAG+L+G L+ G L DR GR+  +    LL   
Sbjct: 118 NRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTL 177

Query: 163 SGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC-YTFG 221
            G   AF P+F +YM  RF     ++G++ S V L  EWV    R   +  L  C ++ G
Sbjct: 178 IGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRT-QAVVLAQCNFSLG 236

Query: 222 QFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAV 281
           Q +L GLAY    WR LQ+T + P  + F   W  PES RWL+  G+  +A++++++ A 
Sbjct: 237 QMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAAS 296

Query: 282 FNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAY 341
            N +K   E ++        Q           A DLFR P LR++T  +   WF     Y
Sbjct: 297 VNRRKLSPELMN--------QLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGY 348

Query: 342 YSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALT 401
           Y L++ V +FG+++Y+ Q+IFG V+VPA+  +I  +   GR  +Q   L+L G   + + 
Sbjct: 349 YGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIII 408

Query: 402 FVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSP 461
           F+P DL  V T+LAV GK   +++F+  ++Y++EL+PT++RQTGMG+  +++R+G +++P
Sbjct: 409 FIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTP 468

Query: 462 LVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEP 521
           LV + GE    +P +IYG   ++ G     LPET  Q L +T++DLE      + PK  P
Sbjct: 469 LVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE-LGPHPRSPKSVP 527

Query: 522 EVEKASQR 529
             ++   +
Sbjct: 528 SEKETEAK 535


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  281 bits (719), Expect = 1e-75
 Identities = 182/545 (33%), Positives = 282/545 (51%), Gaps = 33/545 (6%)

Query: 2   TFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTG--- 58
           T  ++L+  G    FQ     +L L     A   +  +F   TP H CR P  A      
Sbjct: 4   TVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRC 63

Query: 59  --------PWVLP-MGPNGK--PERCLRF----------VHPPNASLPNDTQRA-MEPCL 96
                    + +P  GP G+  P +C R+             P ASL  +  R  + PC 
Sbjct: 64  GWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCR 123

Query: 97  DGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCS 156
           DGWVY +   SIVTE++LVC ++ + ++ QS    G  IG + +G ++DRFGR+  L  +
Sbjct: 124 DGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTT 183

Query: 157 YLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGY 216
            L+ AA+G   A SPT+   ++FR + G       L   IL  E+V  R R  +      
Sbjct: 184 VLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQV 243

Query: 217 CYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKIL 276
            YT G  +L G+AYA+P WRWLQ TV++P F F L  W  PES RWL+   K+++A++I+
Sbjct: 244 AYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRII 303

Query: 277 RRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFA 336
           + +A  NGK       SL+ L+L   +E +  K   +  DL R P +R+ T  L   WF 
Sbjct: 304 KHIAKKNGKSLPA---SLQRLRL---EEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFT 357

Query: 337 TGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGA 396
           +   Y  L M +   G N+Y+       V+ PA F+ IL++  +GR    AA+ ++AG A
Sbjct: 358 SSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAA 417

Query: 397 ILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVG 456
            LA  F+P DLQ ++ +++  G+  ++ ++  + L  +ELYPT IR  G+ + +    +G
Sbjct: 418 CLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIG 477

Query: 457 SMVSP-LVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAK 515
            +++P LV     +   +P +++G+  L+ G   L LPET  + LPETIE+ EN   R +
Sbjct: 478 GIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQ-RPR 536

Query: 516 KPKQE 520
           K K++
Sbjct: 537 KNKEK 541


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  277 bits (709), Expect = 2e-74
 Identities = 182/544 (33%), Positives = 275/544 (50%), Gaps = 33/544 (6%)

Query: 2   TFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP-- 59
           T  +IL++VG  G FQ     IL L     A   +  +F   TP HHC+ P  A      
Sbjct: 3   TVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRC 62

Query: 60  ---------WVLP-MGPNGKP--ERCLRF-----------VHPPNASLPNDTQRAMEPCL 96
                    + +P +GP G+    +C R+           V P  +   N +   + PC 
Sbjct: 63  GWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQ 122

Query: 97  DGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCS 156
           DGWVY++   SIVTE++LVC  +   ++ QS   AG L G L +G  +DRFGR+  L  +
Sbjct: 123 DGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGT 182

Query: 157 YLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGY 216
            L+ A SG   AFSP +   ++FR L G    G  ++   L  E+V +  R  ++     
Sbjct: 183 VLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQM 242

Query: 217 CYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKIL 276
            +T G   L GLAYA+P WRWLQL VS+P F+F L  W  PES RWL+   ++++A+KI+
Sbjct: 243 AFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIM 302

Query: 277 RRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFA 336
             +A  NGK      L   +LK+   +E    K   + +DLFR P LR+ TF L   WF 
Sbjct: 303 DHIAQKNGK------LPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFT 356

Query: 337 TGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGA 396
               Y  L + +     NLY+  +    V++P  FI ++++  +GR    A + LLAG A
Sbjct: 357 DSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAA 416

Query: 397 ILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVG 456
            L + F+  DL  +  ++   G+  ++ +   + L  +ELYPT +R  G+ V +    +G
Sbjct: 417 CLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIG 476

Query: 457 SMVSPLVKI-TGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAK 515
            +++P +     EV   +P I++ +  LL     L LPET    LPET++D EN   +A 
Sbjct: 477 GIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKA- 535

Query: 516 KPKQ 519
           KPK+
Sbjct: 536 KPKE 539


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  272 bits (696), Expect = 5e-73
 Identities = 179/540 (33%), Positives = 271/540 (50%), Gaps = 42/540 (7%)

Query: 2   TFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHH-CRPPHNAS---- 56
           +F E L RVG  G FQ     +L L  +  A   +  +F    P H+ CR P  A+    
Sbjct: 3   SFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAER 62

Query: 57  -----------TGPWVLPMGPNGKPERCLRFV----------------HPPNASLPNDTQ 89
                      T P      P  +  RC R++                  P A+ PN + 
Sbjct: 63  CGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSA 122

Query: 90  RAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGR 149
             + PC  GW Y     +IV+E+DLVC +  + ++ Q+I   G L G   LG  +DR+GR
Sbjct: 123 -PLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGR 181

Query: 150 RPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAI 209
             I   S L +  +G   AF+P FP++++FRFL G    G  ++  ++  E V ++ R I
Sbjct: 182 IVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRI 241

Query: 210 MSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKS 269
           +   +   +T G  ILPG+AY IP W+ +QL +++P F+F L  W  PES RWL+   K 
Sbjct: 242 VGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKG 301

Query: 270 SKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFC 329
            KAL+ILRR+A  NGK      LS    ++ +  E     +  +  DL R P +R+ T  
Sbjct: 302 DKALQILRRIAKCNGK-----YLSSNYSEITVTDE---EVSNPSFLDLVRTPQMRKCTLI 353

Query: 330 LSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAA 389
           L  AWF +   Y  L M +   G NLYI   I G V++P   + +L++  LGR    AA+
Sbjct: 354 LMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAAS 413

Query: 390 LLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVS 449
            ++AG A L   F+P  +  +RT +A  G+  ++ +F  ++L  SELYPT +R  G+ + 
Sbjct: 414 NIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLC 473

Query: 450 NLWTRVGSMVSP-LVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLE 508
           +     G +++P L+     V   +P II+GI A + G   + LPET    LPET++D+E
Sbjct: 474 SGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVE 533


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  261 bits (666), Expect = 2e-69
 Identities = 130/315 (41%), Positives = 202/315 (64%)

Query: 199 VEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPE 258
           +EW   R R ++ T     ++FG  +   +AY +  W  LQL VS+PFF+ FL SWW  E
Sbjct: 1   MEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAE 60

Query: 259 SIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLF 318
           S RWL+ +G+    L+ L RVA  NGK    + L+ E L   +++E+S+ +   +   L 
Sbjct: 61  SARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLL 120

Query: 319 RIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLS 378
           R+P LR  T   +L WFA GF ++ LA+ ++  G N+++LQ+  G VD+PAK   +L LS
Sbjct: 121 RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLS 180

Query: 379 YLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYP 438
           +LGR  T AA+LLLAG  ILA T VP ++  +R+ LAV G G + ++F+C+ +Y+SEL+P
Sbjct: 181 HLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFP 240

Query: 439 TVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQ 498
           TV+R T +G+  +  R G+++ PLV++ G   P++P ++YG   +L G AAL LPET + 
Sbjct: 241 TVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSL 300

Query: 499 PLPETIEDLENWSLR 513
           PLP+TI+D++N +++
Sbjct: 301 PLPDTIQDVQNQAVK 315


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  256 bits (654), Expect = 4e-68
 Identities = 170/530 (32%), Positives = 264/530 (49%), Gaps = 34/530 (6%)

Query: 3   FSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNAS-TGPWV 61
           + E+   +G  G FQ L   +L   I+      L  +F  ATP H CR P  A+ +  W 
Sbjct: 4   YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWR 63

Query: 62  LPMGP----NGK--PERCLRFVHPPNASLPNDTQRAMEP-------------CLDGWVYN 102
               P    +G+  P  C R+     A++ N +   +EP             CLDGW ++
Sbjct: 64  NHTVPLRLRDGREVPHSCRRY---RLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 120

Query: 103 STK--DSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLL 160
                 +IVTEW+LVC  +    +  S+F  G+L+G  + G LSDRFGR+ +L  +  + 
Sbjct: 121 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ 180

Query: 161 AASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC--Y 218
                   FS  F +++V   L G G     ++  +L  E +   +R I ST LG C  Y
Sbjct: 181 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFST-LGVCIFY 239

Query: 219 TFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRR 278
            FG  +LP  AY I  WR L + +++P  +     W+ PES RWL+  G+  +A  I+R+
Sbjct: 240 AFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRK 299

Query: 279 VAVFNGKKEEGERLSLEELK-LNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFAT 337
            A  NG           EL+ L+ +K+ S     +   DL R   +R +T    + W   
Sbjct: 300 AAKANGIVVPSTIFDPSELQDLSSKKQQS-----HNILDLLRTWNIRMVTIMSIMLWMTI 354

Query: 338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAI 397
              Y+ L++       ++++   +   V+VPA  +  L L YL R  + A AL L G  +
Sbjct: 355 SVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVL 414

Query: 398 LALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGS 457
           L +  VP DL  + TVL + GK  ++++FS +++YT+ELYPTV+R  G+GVS+  +R+GS
Sbjct: 415 LFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGS 474

Query: 458 MVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDL 507
           ++SP     G    F+P I+ G   +L     LFLPE+   PLP+TI+ +
Sbjct: 475 ILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQM 524


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  239 bits (610), Expect = 5e-63
 Identities = 168/550 (30%), Positives = 262/550 (47%), Gaps = 38/550 (6%)

Query: 3   FSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNAS-TGPWV 61
           + E++  +G  G FQ L   +L   I+    + +  +F A TP H CR P  A+ +  W 
Sbjct: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWR 63

Query: 62  LPMGP----NGK--PERCLRFVHPPNASLPNDTQRAMEP-------------CLDGWVYN 102
               P    +G+  P  C R+     A++ N +   +EP             CLDGW ++
Sbjct: 64  NNSVPLRLRDGREVPHSCSRY---RLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 120

Query: 103 STK--DSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLL 160
                 ++VTEW+LVC  N    +  S+F  G+L+G  V G LSDRFGR+ +L  +  + 
Sbjct: 121 QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQ 180

Query: 161 AASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTF 220
                   FS ++ ++ V   + G G     +   IL  E +   +R I ST LG C  F
Sbjct: 181 TGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFST-LGVCTFF 239

Query: 221 --GQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRR 278
             G  +LP  AY I  WR L L +++P  +     W+ PES RWL+   +  +A  I+++
Sbjct: 240 AVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQK 299

Query: 279 VAVFNGKKEEGERL-SLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFAT 337
            A  N          S+EEL         L + K    DLFR   +  MT    L W  T
Sbjct: 300 AAKMNNIAVPAVIFDSVEELN-------PLKQQKAFILDLFRTRNIAIMTIMSLLLWMLT 352

Query: 338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAI 397
              Y++L++       + Y+   +   +++PA     L L  L R    AA L   GG +
Sbjct: 353 SVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVL 412

Query: 398 LALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGS 457
           L +  VP+D   +   L + GK  ++S+FS L+++T+ELYPT++R   +GV++  +RVGS
Sbjct: 413 LFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGS 472

Query: 458 MVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLE--NWSLRAK 515
           +++P     G     +P I+ G   +L G   LF PE+L   LPET+E ++   W    K
Sbjct: 473 IIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGK 532

Query: 516 KPKQEPEVEK 525
           K +   E E+
Sbjct: 533 KTRDSMETEE 542


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  236 bits (603), Expect = 3e-62
 Identities = 156/469 (33%), Positives = 234/469 (49%), Gaps = 31/469 (6%)

Query: 2   TFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP-- 59
           T  +IL++VG  G FQ     IL L     A   +  +F   TP HHC+ P  A      
Sbjct: 3   TVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRC 62

Query: 60  ---------WVLP-MGPNGKP--ERCLRF-----------VHPPNASLPNDTQRAMEPCL 96
                    + +P +GP G+    +C R+           V P  +   N +   + PC 
Sbjct: 63  GWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQ 122

Query: 97  DGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCS 156
           DGWVY++   SIVTE++LVC  +   ++ QS   AG L G L +G  +DRFGR+  L  +
Sbjct: 123 DGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGT 182

Query: 157 YLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGY 216
            L+ A SG   AFSP +   ++FR L G    G  ++   L  E+V +  R  ++     
Sbjct: 183 VLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQM 242

Query: 217 CYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKIL 276
            +T G   L GLAYA+P WRWLQL VS+P F+F L  W  PES RWL+   ++++A+KI+
Sbjct: 243 AFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIM 302

Query: 277 RRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFA 336
             +A  NGK      L   +LK+   +E    K   + +DLFR P LR+ TF L   WF 
Sbjct: 303 DHIAQKNGK------LPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFT 356

Query: 337 TGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGA 396
               Y  L + +     NLY+  +    V++P  FI ++++  +GR    A + LLAG A
Sbjct: 357 DSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAA 416

Query: 397 ILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTG 445
            L + F+  DL  +  ++   G+  ++ +   + L  +ELYPT +   G
Sbjct: 417 CLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVG 465


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score =  235 bits (599), Expect = 9e-62
 Identities = 162/536 (30%), Positives = 270/536 (50%), Gaps = 50/536 (9%)

Query: 3   FSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQ--IFTAATPVHHCRPPHNASTGPW 60
           F+ +LD VG  G FQ   VA+  +P +  A        +FTA  P  +C      + GP 
Sbjct: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKP--YCNTSWILAVGPH 109

Query: 61  V---------LPMGPNGKPERCLRFVHPPNASLPNDTQRAM---EPCLDGWVY-NSTKDS 107
           +         +P  PNG    C  ++  P  +L +  Q  +   + C DGW+Y ++ K S
Sbjct: 110 LSKAEQLNLTIPQAPNGSFLTCFMYLPVP-WNLDSIIQFGLNDTDTCQDGWIYPDAKKRS 168

Query: 108 IVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGA 167
           ++ E+DLVC     K+ AQ +FMAG+ IG L+   ++D+ GR P +  S L L   G G 
Sbjct: 169 LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGT 228

Query: 168 AFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC-YTFGQFILP 226
           AF  +F +Y+ FRF     + G  +S++ L  EW+    RA  +  LG+C +  G  +L 
Sbjct: 229 AFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRA-HAIILGHCFFAVGAVLLT 287

Query: 227 GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK 286
           G+AY++P W+ L L   I    F    W  PES RWL++ GK  +A ++L   A  N K 
Sbjct: 288 GIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKK- 346

Query: 287 EEGERLSLEELKLNLQKEISLAKAKYTAS---DLFRIPMLRRMTFCLSLAWFATGFAYYS 343
                     +  NL  E+ L + K T +   D  +   L ++T  +S  WF   + Y++
Sbjct: 347 ---------TIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFT 397

Query: 344 LAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFV 403
           L++ + E GV+++   ++   ++VPA+   I  L  +GR  + A  LL A    L L F+
Sbjct: 398 LSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFL 457

Query: 404 P---------------LDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGV 448
           P                +L+++  ++ +  +  L+++ +  FLYT+EL PTV+R TG+G+
Sbjct: 458 PEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGL 517

Query: 449 SNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETI 504
            +L +  G+++S  + I  +    +P  +  + A++  S +  LPET +QPL E++
Sbjct: 518 VSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  226 bits (576), Expect = 4e-59
 Identities = 164/569 (28%), Positives = 260/569 (45%), Gaps = 44/569 (7%)

Query: 3   FSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNAS------ 56
           F  I D VG  G FQ +   I     ++   H L  +F   TP H CRPP N S      
Sbjct: 6   FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65

Query: 57  --------TGPWV-----------LPMGPNGKPERCLRFVHPPNASLPNDTQRAME--PC 95
                   TG  +           L  G   +  RC R      +SL  +   + +  PC
Sbjct: 66  HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPC 125

Query: 96  LDGWVY--NSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPIL 153
           +DG++Y  N+ K + VT+W+LVC+   L  + Q +FM G+L+G +  G  SDR GRR +L
Sbjct: 126 VDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVL 185

Query: 154 TCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTA 213
             +   +   G  AAF+  +  +M  RF      SG  +   +  +E++  + R   S  
Sbjct: 186 WATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVH 245

Query: 214 LGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKAL 273
           L   +  G  ++    Y +  W   Q+ +S     F L  W  PE+  WL+  G+  +A 
Sbjct: 246 LHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQ 305

Query: 274 KILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKA---KYTASDLFRIPMLRRMTFCL 330
           KI+  +A +N  +    +LS E L L+LQ  +S +     K+  S LF    + + T  +
Sbjct: 306 KIVDIMAKWN--RASSCKLS-ELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTV 362

Query: 331 SLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAAL 390
            L WF     +YS ++     G N Y+   + G V++PA     +++  +GR T  A +L
Sbjct: 363 WLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSL 422

Query: 391 LLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSN 450
             +  A   +  +P     +  V A+ GK  + ++F  ++LYT+ELYPT++R   +G  +
Sbjct: 423 FCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGS 482

Query: 451 LWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENW 510
           +  R+ S+++P       +  FIP +  G  ALL G   L LPETL + L  T E+    
Sbjct: 483 MVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEE---- 538

Query: 511 SLRAKKPKQEPEVEKASQRIPLQPHGPGL 539
                  K E E E  S ++ L  +  GL
Sbjct: 539 -----AAKLESENESKSSKLLLTTNNSGL 562


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  212 bits (540), Expect = 6e-55
 Identities = 142/424 (33%), Positives = 215/424 (50%), Gaps = 22/424 (5%)

Query: 101 YNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLL 160
           ++S+  SI +EW L+ N +     A S F +G+ +G +  G LSDRFGR+ +    + L 
Sbjct: 90  FSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALD 149

Query: 161 AASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTF 220
                   FSP++  + V RFL G    G++L   +L  E V T   A+  +  G  +  
Sbjct: 150 ILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAV 209

Query: 221 GQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVA 280
           G      L Y I  WR L + V++   V FL S + PES RWL   G+ S+A + L  +A
Sbjct: 210 GIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIA 269

Query: 281 VFNGKKEEGERLSLEELKLNLQ-KEISLAKAKYTAS--DLFRIPMLRRMTFCLSLAWFAT 337
             N K           LK        +    + T S  DLFR  +L   T  L   WF  
Sbjct: 270 KRNRK-----------LKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVC 318

Query: 338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPA--KFITILSLSYLGRHTTQAAALLLAGG 395
              YY L +   + G ++Y    + G +++P+    I +++  + GR  T +A L L G 
Sbjct: 319 SLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGL 378

Query: 396 AILALTFVPLDLQT-VRTV-----LAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVS 449
           A L + F+P    T V  V     L++ GK  +S++F+ +++YTSELYPTVIR  G+G  
Sbjct: 379 ACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTC 438

Query: 450 NLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLEN 509
           ++++RVG +++P +     VQ  +P I++G T L  G  +L LPETLN PL ET  DL+ 
Sbjct: 439 SMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQV 498

Query: 510 WSLR 513
           +S R
Sbjct: 499 YSYR 502


>gi|24308167 SV2 related protein [Homo sapiens]
          Length = 548

 Score =  142 bits (359), Expect = 6e-34
 Identities = 114/414 (27%), Positives = 191/414 (46%), Gaps = 57/414 (13%)

Query: 127 SIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFG 186
           S+   G++    + G++SD++GR+  L  S L     G  +AF+P +   +V R L GFG
Sbjct: 127 SVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFG 186

Query: 187 ISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQ--------FILPGLAYAIPQWRWL 238
           I G+  S V L  E++P + RA     +   +  G         F++P L      WRWL
Sbjct: 187 IGGVPQS-VTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLG-----WRWL 240

Query: 239 QLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELK 298
            +  ++P  +F +  +W PES R+ VLSG   KA+  L+R+A      E G  + L +L 
Sbjct: 241 LILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIAT-----ENGAPMPLGKLI 295

Query: 299 LNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEF------- 351
           ++ Q++      +    DLF  P  R  T  L   WF+  F+YY L +   E        
Sbjct: 296 ISRQED------RGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVC 348

Query: 352 GVNL--------------YILQIIFGGV------DVPAKFITILSLSYLGRHTTQAAALL 391
           G++               Y+ +  +  +      + P   +T+  +  LGR  T A   +
Sbjct: 349 GISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFV 408

Query: 392 LAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNL 451
           +     L L F+ +  + V T+L    +  +S  F   ++YT E+YPT  R  G+G  + 
Sbjct: 409 IFSFCSL-LLFICVG-RNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSG 466

Query: 452 WTRVGSMVSPLV-KITGEVQPFIPNIIYGITALLGGSAALFLP-ETLNQPLPET 503
             RVG++++P + ++  E   ++   +Y    LL   A+ FLP ET  + L E+
Sbjct: 467 MARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520


>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score =  137 bits (346), Expect = 2e-32
 Identities = 145/549 (26%), Positives = 227/549 (41%), Gaps = 47/549 (8%)

Query: 4   SEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHN-------AS 56
           + +L   G  G  + L  +   +P + +      +    A P  HCRP          A 
Sbjct: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRAL 64

Query: 57  TGPWVLP-----MGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTE 111
            GP +L      +GP   P   L  + P   S      RA  P    W   S   +  T 
Sbjct: 65  RGPALLDAAIPRLGPTRAPAEALGVLSP---SYLAPLTRAPRP--SSWASCSGAAAGPT- 118

Query: 112 WDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSP 171
           W+LVC       + Q   + G L+G ++LG   DRFGRR +   S +L    G+  A + 
Sbjct: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178

Query: 172 TFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYA 231
           +FP  +V R L G  ++G  L+  +  +E      R   S   G     G  +LPGLA  
Sbjct: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238

Query: 232 IPQWRWLQ---LTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEE 288
           +  WR LQ     +S    +F+      PES  WL+ +G+ ++A KIL R A  +G    
Sbjct: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 298

Query: 289 GERLSLEELKLNLQKEISLAKAK------YTASDLFRIPMLRRMTFCLSLAWFATGFAYY 342
               SLEE  L    E+++  A+      ++   L R  +  R    L  +    G    
Sbjct: 299 DS--SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRA 356

Query: 343 SLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRH--------TTQAAALLLAG 394
           S    +       Y+   +  G++  A    +L+    GR          T  A+LLL  
Sbjct: 357 SFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLA 416

Query: 395 GAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTR 454
           GA     +  L L +V  +LA      LSS      L+ +E++PTVIR  G+G+      
Sbjct: 417 GAQYLPGWTVLFL-SVLGLLASRAVSALSS------LFAAEVFPTVIRGAGLGLVLGAGF 469

Query: 455 VGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIED---LENWS 511
           +G    PL  + G    F+  +++   A+L     L LPE+ ++ LP++++D   L    
Sbjct: 470 LGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSP 529

Query: 512 LRAKKPKQE 520
           L   +P+Q+
Sbjct: 530 LLRGRPRQD 538


>gi|170650643 solute carrier family 22, member 23 isoform a [Homo
           sapiens]
          Length = 686

 Score =  135 bits (341), Expect = 7e-32
 Identities = 118/474 (24%), Positives = 212/474 (44%), Gaps = 38/474 (8%)

Query: 79  PPNASLPNDTQRAMEPCLDGWVYN---STKDSIVTEWDLVCNSNKLKEMAQSIFMAGILI 135
           PP  S P+    A       W Y        ++V++WDLVC++     +A+   + G++ 
Sbjct: 183 PPLPSPPDKGDNASNCDCRAWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIF 242

Query: 136 GGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTV 195
           G L+ G ++D  GRRP+L  S + +   G   A S    ++   RF  GF ++GI L+  
Sbjct: 243 GYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLY 302

Query: 196 ILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWW 255
            L +E  P   R +++    +    GQF++PGLA     W+ LQ  +  PF +  L  +W
Sbjct: 303 ALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLL--YW 360

Query: 256 T--PESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYT 313
           +  PES+RWL+ + +   A +++      N    EG+   ++ +   L+KE+S    K  
Sbjct: 361 SIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGD---IKGVIPELEKELSRRPKKVC 417

Query: 314 ASDLFRIPMLRR--MTFCL-SLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAK 370
              +     L +  +  C+ SL  +     +    MG E   V + +L+  +      A 
Sbjct: 418 IVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHE---VKVPLLENFYADYYTTAS 474

Query: 371 FITILSLS------YLGRHTTQAAALLLAGGAIL----ALTFVPLDLQTVRTVLAVFGKG 420
              +  L+      +LGR       ++L   A L     L  +    Q   + ++   K 
Sbjct: 475 IALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKD 534

Query: 421 CLSSSFSCLFLYTS------------ELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGE 468
             S +FS + ++ S            E+ PTVIR  G+G+       G + +P++++  +
Sbjct: 535 KFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQ 594

Query: 469 VQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPE 522
              F+ +II+    L+     L LPE+ +Q LPE I + E+++ +   P ++ E
Sbjct: 595 KGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPLLPHKKGE 648


>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
           [Homo sapiens]
          Length = 560

 Score =  132 bits (332), Expect = 8e-31
 Identities = 145/550 (26%), Positives = 227/550 (41%), Gaps = 47/550 (8%)

Query: 4   SEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHN-------AS 56
           + +L   G  G  + L  +   +P + +      +    A P  HCRP          A 
Sbjct: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRAL 64

Query: 57  TGPWVLP-----MGPNGKPERCLRF-VHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVT 110
            GP +L      +GP      CL   V  P+   P    RA  P    W   S   +  T
Sbjct: 65  RGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAP--LTRAPRP--SSWASCSGAAAGPT 120

Query: 111 EWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFS 170
            W+LVC       + Q   + G L+G ++LG   DRFGRR +   S +L    G+  A +
Sbjct: 121 -WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALA 179

Query: 171 PTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAY 230
            +FP  +V R L G  ++G  L+  +  +E      R   S   G     G  +LPGLA 
Sbjct: 180 ASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAA 239

Query: 231 AIPQWRWLQ---LTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKE 287
            +  WR LQ     +S    +F+      PES  WL+ +G+ ++A KIL R A  +G   
Sbjct: 240 LVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGP 299

Query: 288 EGERLSLEELKLNLQKEISLAKAK------YTASDLFRIPMLRRMTFCLSLAWFATGFAY 341
                SLEE  L    E+++  A+      ++   L R  +  R    L  +    G   
Sbjct: 300 GDS--SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIR 357

Query: 342 YSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRH--------TTQAAALLLA 393
            S    +       Y+   +  G++  A    +L+    GR          T  A+LLL 
Sbjct: 358 ASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLL 417

Query: 394 GGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWT 453
            GA     +  L L +V  +LA      LSS      L+ +E++PTVIR  G+G+     
Sbjct: 418 AGAQYLPGWTVLFL-SVLGLLASRAVSALSS------LFAAEVFPTVIRGAGLGLVLGAG 470

Query: 454 RVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIED---LENW 510
            +G     L  + G    F+  +++   A+L     L LPE+ ++ LP++++D   L   
Sbjct: 471 FLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRS 530

Query: 511 SLRAKKPKQE 520
            L   +P+Q+
Sbjct: 531 PLLRGRPRQD 540


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  125 bits (315), Expect = 8e-29
 Identities = 125/491 (25%), Positives = 205/491 (41%), Gaps = 26/491 (5%)

Query: 39  IFTAATPVH--HCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQRA----- 91
           IFT A P+H  +   P NAS   W  P   +G             + +   T  +     
Sbjct: 6   IFTLAPPLHCHYGAFPPNASG--WEQPPNASGVSVASAALAASAASRVATSTDPSCSGFA 63

Query: 92  ---MEPCLDGWVYNSTK---DSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSD 145
                 CL  W YN       + + +WDLVC+      + Q +F+ G   G L LG  +D
Sbjct: 64  PPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPAD 123

Query: 146 RFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTR 205
           RFGRR I+  +  L+   G G A + +    M  RFL GF ++G+ L   ++ +E     
Sbjct: 124 RFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPT 183

Query: 206 MRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSW--WTPESIRWL 263
            R  ++ A       G F+  GLA     WR+LQ  ++ P  +F    W     ES RWL
Sbjct: 184 QRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWL 243

Query: 264 VLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPML 323
           ++  +  +A  +LR +A  N  +  G+ L  EE +  LQ   +      T+S  F   + 
Sbjct: 244 IVKRQIEEAQSVLRILAERN--RPHGQMLG-EEAQEALQDLENTCPLPATSSFSFASLLN 300

Query: 324 RRMTFCLSLAWFATGFAYYSLAMGVEEFG-----VNLYILQIIFGGVDVPAKFITILSLS 378
            R  +   L    T F  +++    +  G      + Y+  ++  G    A     +++ 
Sbjct: 301 YRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVD 360

Query: 379 YLGRHTTQAAALLLAGGAILALTFVPLDL-QTVRTVLAVFGKGCLSSSFSCLFLYTSELY 437
             GR      ++ L G A L L  +   L +   T  +V G     ++     L  +E+ 
Sbjct: 361 RFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVI 420

Query: 438 PTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLN 497
           PT +R  G+G+      +G +  P  ++      F+ +++    ALL   + + LPET  
Sbjct: 421 PTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKR 480

Query: 498 QPLPETIEDLE 508
           + LPE + D E
Sbjct: 481 KLLPEVLRDGE 491


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,784,248
Number of Sequences: 37866
Number of extensions: 954187
Number of successful extensions: 3463
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 3262
Number of HSP's gapped (non-prelim): 108
length of query: 542
length of database: 18,247,518
effective HSP length: 107
effective length of query: 435
effective length of database: 14,195,856
effective search space: 6175197360
effective search space used: 6175197360
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.