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Search of human proteins with 24308541
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24308541 HtrA serine peptidase 4 precursor [Homo sapiens]
(476 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24308541 HtrA serine peptidase 4 precursor [Homo sapiens] 963 0.0
gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens] 474 e-134
gi|22129776 HtrA serine peptidase 3 [Homo sapiens] 425 e-119
gi|7019477 HtrA serine peptidase 2 isoform 1 preproprotein [Homo... 294 1e-79
gi|21614538 HtrA serine peptidase 2 isoform 2 [Homo sapiens] 93 5e-19
gi|4504619 insulin-like growth factor binding protein 7 [Homo sa... 90 5e-18
gi|56090548 insulin-like growth factor binding protein-like 1 [H... 84 2e-16
gi|5901946 endothelial cell-specific molecule 1 isoform a precur... 55 1e-07
gi|208022668 endothelial cell-specific molecule 1 isoform b prec... 55 1e-07
gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens] 50 6e-06
gi|4507923 WNT1 inducible signaling pathway protein 2 precursor ... 46 6e-05
gi|4503123 connective tissue growth factor [Homo sapiens] 43 7e-04
gi|31542331 cysteine-rich, angiogenic inducer, 61 [Homo sapiens] 42 0.001
gi|19923632 Kazal-type serine peptidase inhibitor domain 1 precu... 41 0.002
gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens] 40 0.005
gi|54873613 agrin [Homo sapiens] 39 0.010
gi|55925576 insulin-like growth factor binding protein 2, 36kDa ... 37 0.030
gi|193083191 synaptopodin 2 isoform c [Homo sapiens] 37 0.030
gi|193083185 synaptopodin 2 isoform b [Homo sapiens] 37 0.030
gi|193083183 synaptopodin 2 isoform a [Homo sapiens] 37 0.030
gi|13376349 PDZ domain containing 7 [Homo sapiens] 37 0.039
gi|30387656 late cornified envelope 1B [Homo sapiens] 37 0.039
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens] 37 0.039
gi|225690576 keratin associated protein 2-2 [Homo sapiens] 37 0.051
gi|38202241 WNT1 inducible signaling pathway protein 3 isoform 3... 37 0.051
gi|4507925 WNT1 inducible signaling pathway protein 3 isoform 1 ... 37 0.051
gi|169211819 PREDICTED: keratin associated protein [Homo sapiens] 37 0.051
gi|239745811 PREDICTED: hypothetical protein XP_002343557 [Homo ... 37 0.051
gi|10834982 insulin-like growth factor binding protein 5 [Homo s... 36 0.067
gi|239752912 PREDICTED: hypothetical protein [Homo sapiens] 36 0.067
>gi|24308541 HtrA serine peptidase 4 precursor [Homo sapiens]
Length = 476
Score = 963 bits (2489), Expect = 0.0
Identities = 476/476 (100%), Positives = 476/476 (100%)
Query: 1 MIRPQLRTAGLGRCLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTT 60
MIRPQLRTAGLGRCLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTT
Sbjct: 1 MIRPQLRTAGLGRCLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTT 60
Query: 61 PVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDR 120
PVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDR
Sbjct: 61 PVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDR 120
Query: 121 RTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAPS 180
RTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAPS
Sbjct: 121 RTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAPS 180
Query: 181 VVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNGARYEAVV 240
VVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNGARYEAVV
Sbjct: 181 VVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNGARYEAVV 240
Query: 241 KDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGIVSTKQR 300
KDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGIVSTKQR
Sbjct: 241 KDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGIVSTKQR 300
Query: 301 GGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQ 360
GGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQ
Sbjct: 301 GGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQ 360
Query: 361 FLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTA 420
FLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTA
Sbjct: 361 FLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTA 420
Query: 421 AQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIPETIN 476
AQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIPETIN
Sbjct: 421 AQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIPETIN 476
>gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens]
Length = 480
Score = 474 bits (1220), Expect = e-134
Identities = 251/478 (52%), Positives = 328/478 (68%), Gaps = 22/478 (4%)
Query: 15 LLPGLLLLLVPVLWAGAEKLHTQP----SCPAVCQPTRCPALPTCALGTTPVFDLCRCCR 70
LLP LLLLL A + CP C+P RCP P G D C CC
Sbjct: 8 LLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGR-ARDACGCCE 66
Query: 71 VCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPST-----------CGCPTLGGAVCGSD 119
VC A E CG +G PC GLQC+ P G P++ C C + VCGSD
Sbjct: 67 VCGAPEGAACGLQEG-PCGEGLQCVVPF--GVPASATVRRRAQAGLCVCAS-SEPVCGSD 122
Query: 120 RRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAP 179
TY ++C LRA +R + RL + P + +Q G CG G LR YNFIA VVEK+AP
Sbjct: 123 ANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQ-GQEDPNSLRHKYNFIADVVEKIAP 181
Query: 180 SVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNGARYEAV 239
+VVH++L+ +L R VPV SGSGFIVSEDGLI+TNAHVV N+ ++V L+NGA YEA
Sbjct: 182 AVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAK 241
Query: 240 VKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGIVSTKQ 299
+KD+D K D+A+IKI+ +LPVL+LGRSS+LR GEFVVA+GSPFSLQNT T GIVST Q
Sbjct: 242 IKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQ 301
Query: 300 RGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVR 359
RGGKELG+++SDMDY+Q DA INYGNSGGPLVNLDG+VIG+N+L+VT GISFAIPSD+++
Sbjct: 302 RGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIK 361
Query: 360 QFLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGT 419
+FL E H+ Q KGKA + KKY+G++M+SLT ++ELK + DFPDV SG Y+ +V+ T
Sbjct: 362 KFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDT 421
Query: 420 AAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDS-LSMAVLRGKDNLLLTVIPETIN 476
A++ GL+++DVI++ING+ + + DV + +S L+M V RG +++++TVIPE I+
Sbjct: 422 PAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEID 479
>gi|22129776 HtrA serine peptidase 3 [Homo sapiens]
Length = 453
Score = 425 bits (1092), Expect = e-119
Identities = 227/443 (51%), Positives = 304/443 (68%), Gaps = 22/443 (4%)
Query: 40 CPAVCQPTRCPALPTCALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLR 99
CPA C +RCP+ P C G P DLC CC VC A+E E CGG PC L+C++ L
Sbjct: 25 CPARCDVSRCPS-PRCPGGYVP--DLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGL- 80
Query: 100 PGFPSTCGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRS 159
C C AVCG+D TY ++CAL+A +R A +L P +Q G C G
Sbjct: 81 ------CRC-RWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGAC-PLGLHQ 132
Query: 160 AGPLRRNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHV 219
R +NFIA VVEK+AP+VVH++L+ R R VP+ SGSGFI+SE GLIITNAHV
Sbjct: 133 LSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHV 192
Query: 220 VRN------QQWIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRA 273
V + +Q ++V LQNG YEA +KDID K D+A IKI +LPVL+LG S+DLR
Sbjct: 193 VSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRP 252
Query: 274 GEFVVALGSPFSLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNL 333
GEFVVA+GSPF+LQNT T GIVST QR G+ELG++DSDMDY+Q DA INYGNSGGPLVNL
Sbjct: 253 GEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNL 312
Query: 334 DGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLS 393
DG+VIG+N+L+VT GISFAIPSDR+ +FL E+ + Q+K K+++G++M ++T L
Sbjct: 313 DGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKD---WKKRFIGIRMRTITPSLV 369
Query: 394 EELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSD 453
+ELK PDFP+VSSG+YV +V + +Q G++D D+IV +NG+P+ ++++ +A+ ++
Sbjct: 370 DELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTE 429
Query: 454 S-LSMAVLRGKDNLLLTVIPETI 475
S L + V RG D+LL ++ PE +
Sbjct: 430 SPLLLEVRRGNDDLLFSIAPEVV 452
>gi|7019477 HtrA serine peptidase 2 isoform 1 preproprotein [Homo
sapiens]
Length = 458
Score = 294 bits (753), Expect = 1e-79
Identities = 153/312 (49%), Positives = 223/312 (71%), Gaps = 2/312 (0%)
Query: 164 RRNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQ 223
R YNFIA VVEK AP+VV++++ R R VP+ +GSGF+V+ DGLI+TNAHVV ++
Sbjct: 144 RSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADR 203
Query: 224 QWIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSP 283
+ + V L +G YEAVV +D D+A ++I++ LP L LGRS+D+R GEFVVA+GSP
Sbjct: 204 RRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSP 263
Query: 284 FSLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSL 343
F+LQNT T+GIVS+ QR ++LG+ ++++Y+Q DA I++GNSGGPLVNLDG+VIGVN++
Sbjct: 264 FALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTM 323
Query: 344 RVTDGISFAIPSDRVRQFLAE-YHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPD 402
+VT GISFAIPSDR+R+FL ++ G + S ++Y+G+ ML+L+ + EL++ P
Sbjct: 324 KVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPS 383
Query: 403 FPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDS-LSMAVLR 461
FPDV GV + KV+ G+ A +GLR DVI+ I + + DV +A+ + S L++ + R
Sbjct: 384 FPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRR 443
Query: 462 GKDNLLLTVIPE 473
G++ L L V PE
Sbjct: 444 GRETLTLYVTPE 455
>gi|21614538 HtrA serine peptidase 2 isoform 2 [Homo sapiens]
Length = 361
Score = 93.2 bits (230), Expect = 5e-19
Identities = 60/167 (35%), Positives = 89/167 (53%), Gaps = 34/167 (20%)
Query: 309 DSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAE-YHE 367
D D + +GNSGGPLVNLDG+VIGVN+++VT GISFAIPSDR+R+FL +
Sbjct: 224 DPVADIATLRIQTKFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKK 283
Query: 368 HQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLR 427
+ G + S ++Y+G+ ML+L + +GLR
Sbjct: 284 NSSSGISGSQRRYIGVMMLTL--------------------------------SPRAGLR 311
Query: 428 DHDVIVNINGKPITTTTDVVKALDSDS-LSMAVLRGKDNLLLTVIPE 473
DVI+ I + + DV +A+ + S L++ + RG++ L L V PE
Sbjct: 312 PGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPE 358
Score = 90.9 bits (224), Expect = 2e-18
Identities = 54/157 (34%), Positives = 88/157 (56%), Gaps = 4/157 (2%)
Query: 164 RRNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQ 223
R YNFIA VVEK AP+VV++++ R R VP+ +GSGF+V+ DGLI+TNAHVV ++
Sbjct: 144 RSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADR 203
Query: 224 QWIEVVLQNGARYEAVVKDIDLKLDLAVIKIES---NAELPVLMLGRSSDLRAGEFVVAL 280
+ + V L +G YEAVV +D D+A ++I++ N+ P++ L + V
Sbjct: 204 RRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKFGNSGGPLVNLD-GEVIGVNTMKVTA 262
Query: 281 GSPFSLQNTATAGIVSTKQRGGKELGMKDSDMDYVQI 317
G F++ + + ++ G+ S Y+ +
Sbjct: 263 GISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGV 299
>gi|4504619 insulin-like growth factor binding protein 7 [Homo
sapiens]
Length = 282
Score = 89.7 bits (221), Expect = 5e-18
Identities = 72/212 (33%), Positives = 94/212 (44%), Gaps = 32/212 (15%)
Query: 1 MIRPQLRTAGLGRCLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPT--CALG 58
M RP LR LG GLLLLL+P+ + +C C+P CP LP C LG
Sbjct: 1 MERPSLRALLLGAA---GLLLLLLPL-----SSSSSSDTC-GPCEPASCPPLPPLGCLLG 51
Query: 59 TTPVFDLCRCCRVCPAAEREVC--GGAQGQPCAPGLQCLQPLR------------PGFPS 104
T D C CC +C E E C GGA CAPG++C++ + PG
Sbjct: 52 ETR--DACGCCPMCARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGAAAGGPGVSG 109
Query: 105 TCGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLR 164
C C + VCGSD TYPS C LRA ++ A G+ V G C + G P +
Sbjct: 110 VCVCKS-RYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTC-EQGPSIVTPPK 167
Query: 165 RNYNFIAAVVE---KVAPSVVHVQLWGRLLHG 193
+N A V +V V +W ++ G
Sbjct: 168 DIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRG 199
>gi|56090548 insulin-like growth factor binding protein-like 1 [Homo
sapiens]
Length = 278
Score = 84.3 bits (207), Expect = 2e-16
Identities = 53/132 (40%), Positives = 60/132 (45%), Gaps = 9/132 (6%)
Query: 15 LLPGLLLLLVPVLWAGAEKLHTQ------PSCPAVCQPTRCPALPTCALGTTPVFDLCRC 68
LLP LLLLL+P+L + L + P C C+P CPA C D C C
Sbjct: 7 LLPLLLLLLLPLLPPLSPSLGIRDVGGRRPKC-GPCRPEGCPAPAPCPAPGISALDECGC 65
Query: 69 CRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLG--GAVCGSDRRTYPSM 126
C C AE CGG G C PGL C P G G VCGSD R+YPS+
Sbjct: 66 CARCLGAEGASCGGRAGGRCGPGLVCASQAAGAAPEGTGLCVCAQRGTVCGSDGRSYPSV 125
Query: 127 CALRAENRAARR 138
CALR R R
Sbjct: 126 CALRLRARHTPR 137
>gi|5901946 endothelial cell-specific molecule 1 isoform a
precursor [Homo sapiens]
Length = 184
Score = 55.1 bits (131), Expect = 1e-07
Identities = 30/80 (37%), Positives = 34/80 (42%), Gaps = 7/80 (8%)
Query: 19 LLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTTPVFDLCRCCRVCPAAERE 78
L LLVP A + CP C + C + P C V D C CCRVC A E
Sbjct: 7 LTTLLVPAHLVAAWSNNYAVDCPQHCDSSECKSSPRCK---RTVLDDCGCCRVCAAGRGE 63
Query: 79 VC----GGAQGQPCAPGLQC 94
C G G C PGL+C
Sbjct: 64 TCYRTVSGMDGMKCGPGLRC 83
>gi|208022668 endothelial cell-specific molecule 1 isoform b
precursor [Homo sapiens]
Length = 134
Score = 55.1 bits (131), Expect = 1e-07
Identities = 30/80 (37%), Positives = 34/80 (42%), Gaps = 7/80 (8%)
Query: 19 LLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTTPVFDLCRCCRVCPAAERE 78
L LLVP A + CP C + C + P C V D C CCRVC A E
Sbjct: 7 LTTLLVPAHLVAAWSNNYAVDCPQHCDSSECKSSPRCK---RTVLDDCGCCRVCAAGRGE 63
Query: 79 VC----GGAQGQPCAPGLQC 94
C G G C PGL+C
Sbjct: 64 TCYRTVSGMDGMKCGPGLRC 83
>gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens]
Length = 357
Score = 49.7 bits (117), Expect = 6e-06
Identities = 40/113 (35%), Positives = 46/113 (40%), Gaps = 4/113 (3%)
Query: 14 CLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALP-TCALGTTPVFDLCRCCRVC 72
CL L L +L + TQ CP C P RCPA P TCA G V D C CC VC
Sbjct: 10 CLRKQCLCLTFLLLHLLGQVAATQ-RCPPQC-PGRCPATPPTCAPGVRAVLDGCSCCLVC 67
Query: 73 PAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTYPS 125
E C + + GL C + P T C + G C D Y S
Sbjct: 68 ARQRGESCSDLEPCDESSGLYCDRSADPS-NQTGICTAVEGDNCVFDGVIYRS 119
>gi|4507923 WNT1 inducible signaling pathway protein 2 precursor
[Homo sapiens]
Length = 250
Score = 46.2 bits (108), Expect = 6e-05
Identities = 28/66 (42%), Positives = 31/66 (46%), Gaps = 11/66 (16%)
Query: 33 KLHTQPSCPAVCQPTRCP-ALPTCALGTTPVFDLCRCCRVC------PAAEREVCGGAQG 85
K+ TQ CP C CP P C LG V D C CCRVC P + VC +QG
Sbjct: 20 KVRTQ-LCPTPCT---CPWPPPRCPLGVPLVLDGCGCCRVCARRLGEPCDQLHVCDASQG 75
Query: 86 QPCAPG 91
C PG
Sbjct: 76 LVCQPG 81
>gi|4503123 connective tissue growth factor [Homo sapiens]
Length = 349
Score = 42.7 bits (99), Expect = 7e-04
Identities = 28/64 (43%), Positives = 31/64 (48%), Gaps = 10/64 (15%)
Query: 39 SCPAVCQ----PTRCP--ALPTCALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAP-- 90
S PAV Q P RCP P C G + V D C CCRVC E+C + PC P
Sbjct: 21 SRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELC--TERDPCDPHK 78
Query: 91 GLQC 94
GL C
Sbjct: 79 GLFC 82
>gi|31542331 cysteine-rich, angiogenic inducer, 61 [Homo sapiens]
Length = 381
Score = 42.4 bits (98), Expect = 0.001
Identities = 25/59 (42%), Positives = 30/59 (50%), Gaps = 8/59 (13%)
Query: 39 SCPAVCQPTRCPA-LPTCALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPC--APGLQC 94
+CPA C CP P CA G V D C CC+VC E C ++ QPC GL+C
Sbjct: 25 TCPAACH---CPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDC--SKTQPCDHTKGLEC 78
>gi|19923632 Kazal-type serine peptidase inhibitor domain 1
precursor [Homo sapiens]
Length = 304
Score = 41.2 bits (95), Expect = 0.002
Identities = 47/160 (29%), Positives = 59/160 (36%), Gaps = 31/160 (19%)
Query: 1 MIRPQLRTAGLGRCLLPGLLLLLVPV---------------LWAGAEKLHTQPSCPAVCQ 45
M+ P A L LP LLLLLV + L G +L + A C+
Sbjct: 1 MLPPPRPAAALA---LPVLLLLLVVLTPPPTGARPSPGPDYLRRGWMRLLAEGEGCAPCR 57
Query: 46 PTRCPALPTCALGTTPVFDLCRCCRVCPAAEREVCGGAQGQP----CAPGLQCLQPL--- 98
P C A C G V D C CC C E ++C C L+C
Sbjct: 58 PEECAAPRGCLAGR--VRDACGCCWECANLEGQLCDLDPSAHFYGHCGEQLECRLDTGGD 115
Query: 99 --RPGFPST-CGCPTLGGAVCGSDRRTYPSMCALRAENRA 135
R P C C + +CGSD TY +C L+ RA
Sbjct: 116 LSRGEVPEPLCACRSQS-PLCGSDGHTYSQICRLQEAARA 154
>gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]
Length = 1036
Score = 40.0 bits (92), Expect = 0.005
Identities = 32/96 (33%), Positives = 43/96 (44%), Gaps = 15/96 (15%)
Query: 10 GLGRC--LLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQ-PTRCPALPTCALGTTPVFDLC 66
GL C LL LL LL+ + +G L P + C+ P CP + V +C
Sbjct: 9 GLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPG--------SIVQGVC 60
Query: 67 RCCRVCPAAEREVCGGAQG--QPCAPGLQCLQPLRP 100
CC C + E CGG G C GL+C+ +RP
Sbjct: 61 GCCYTCASQRNESCGGTFGIYGTCDRGLRCV--IRP 94
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 38.9 bits (89), Expect = 0.010
Identities = 32/119 (26%), Positives = 40/119 (33%), Gaps = 33/119 (27%)
Query: 41 PAVCQPTRCPALPTCALGTTPVFDLCRCCRVCPAAEREVCGG----------AQGQPCAP 90
P+ C +C TCA+ C C + C + VCG + C
Sbjct: 465 PSPCLGVQCAFGATCAVKNGQA--ACECLQACSSLYDPVCGSDGVTYGSACELEATACTL 522
Query: 91 GLQCLQPLRPGFPSTCG--------------------CPTLGGAVCGSDRRTYPSMCAL 129
G + +Q R G CG C L VCGSD TYPS C L
Sbjct: 523 GRE-IQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECML 580
Score = 37.7 bits (86), Expect = 0.023
Identities = 28/104 (26%), Positives = 41/104 (39%), Gaps = 18/104 (17%)
Query: 43 VCQPTRCPAL--PTCALGTTPVFDLCRCCRVCPAAEREV-------CGG---AQGQPCAP 90
VC+ + CP++ P C + + C R + +R + CG C+
Sbjct: 196 VCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSF 255
Query: 91 GLQCLQPLRPGFPSTCGCPTL-----GGAVCGSDRRTYPSMCAL 129
G C + G ++C CP G VCGSD YP C L
Sbjct: 256 GSTCARSA-DGLTASCLCPATCRGAPEGTVCGSDGADYPGECQL 298
Score = 36.6 bits (83), Expect = 0.051
Identities = 32/94 (34%), Positives = 37/94 (39%), Gaps = 15/94 (15%)
Query: 71 VCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLG----GAVCGSDRRTYPSM 126
V A E CG A CA G C C CP G VCGSD TY S
Sbjct: 593 VASAGPCETCGDAV---CAFGAVCSA-------GQCVCPRCEHPPPGPVCGSDGVTYGSA 642
Query: 127 CALR-AENRAARRLGKVPAVPVQWGNCGDTGTRS 159
C LR A ++ + A P + CG G+ S
Sbjct: 643 CELREAACLQQTQIEEARAGPCEQAECGSGGSGS 676
Score = 33.9 bits (76), Expect = 0.33
Identities = 27/79 (34%), Positives = 32/79 (40%), Gaps = 21/79 (26%)
Query: 66 CRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCG-------------CPTLG 112
CR R P+ + C A PC G+QC F +TC C +L
Sbjct: 447 CRQQRAIPSKHQGPCDQAPS-PCL-GVQC------AFGATCAVKNGQAACECLQACSSLY 498
Query: 113 GAVCGSDRRTYPSMCALRA 131
VCGSD TY S C L A
Sbjct: 499 DPVCGSDGVTYGSACELEA 517
Score = 31.2 bits (69), Expect = 2.2
Identities = 24/66 (36%), Positives = 32/66 (48%), Gaps = 12/66 (18%)
Query: 79 VCG-GAQGQPCAPG---LQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTYPSMCAL-RAEN 133
+CG GA +P A G C+ P CP++ VCGSD TY + C L RA+
Sbjct: 176 LCGFGAVCEPNAEGPGRASCVCKKSP-------CPSVVAPVCGSDASTYSNECELQRAQC 228
Query: 134 RAARRL 139
RR+
Sbjct: 229 SQQRRI 234
Score = 29.3 bits (64), Expect = 8.2
Identities = 32/120 (26%), Positives = 39/120 (32%), Gaps = 14/120 (11%)
Query: 31 AEKLHTQPSCPAVCQPTRCPALPTCALGTTPVFDLCRCCRVCPAAEREV-------CGGA 83
A+ L CPA C+ P C C+ R A + V C
Sbjct: 263 ADGLTASCLCPATCRGA--PEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPC 320
Query: 84 QGQPCAPGLQCLQPLRPGFPSTC----GCPTLGGAVCGSDRRTYPSMCALRAENRAARRL 139
QG P C R P CP VCG D TY + C + + AAR L
Sbjct: 321 QGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVM-GRSGAARGL 379
>gi|55925576 insulin-like growth factor binding protein 2, 36kDa
[Homo sapiens]
Length = 328
Score = 37.4 bits (85), Expect = 0.030
Identities = 37/123 (30%), Positives = 42/123 (34%), Gaps = 21/123 (17%)
Query: 15 LLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRC------PALPTCALGTT------PV 62
LLP LLLLL G + CP C P R P P A+ P
Sbjct: 20 LLPLLLLLLGASGGGGGARAEVLFRCPP-CTPERLAACGPPPVAPPAAVAAVAGGARMPC 78
Query: 63 FDL-----CRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCG 117
+L C CC VC E E C G C GL+C PG +G C
Sbjct: 79 AELVREPGCGCCSVCARLEGEAC-GVYTPRCGQGLRCYP--HPGSELPLQALVMGEGTCE 135
Query: 118 SDR 120
R
Sbjct: 136 KRR 138
>gi|193083191 synaptopodin 2 isoform c [Homo sapiens]
Length = 1109
Score = 37.4 bits (85), Expect = 0.030
Identities = 24/69 (34%), Positives = 36/69 (52%), Gaps = 4/69 (5%)
Query: 412 VCKVVEGTAAQSSGLRDHDVIVNINGKPITTTT--DVVKALDS--DSLSMAVLRGKDNLL 467
V K+ + A SGL + D +V+ING P T +V+K ++S DSL M + R +
Sbjct: 33 VAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPEVIKLMESITDSLQMLIKRPSSGIS 92
Query: 468 LTVIPETIN 476
+I E N
Sbjct: 93 EALISENEN 101
>gi|193083185 synaptopodin 2 isoform b [Homo sapiens]
Length = 1093
Score = 37.4 bits (85), Expect = 0.030
Identities = 24/69 (34%), Positives = 36/69 (52%), Gaps = 4/69 (5%)
Query: 412 VCKVVEGTAAQSSGLRDHDVIVNINGKPITTTT--DVVKALDS--DSLSMAVLRGKDNLL 467
V K+ + A SGL + D +V+ING P T +V+K ++S DSL M + R +
Sbjct: 33 VAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPEVIKLMESITDSLQMLIKRPSSGIS 92
Query: 468 LTVIPETIN 476
+I E N
Sbjct: 93 EALISENEN 101
>gi|193083183 synaptopodin 2 isoform a [Homo sapiens]
Length = 1261
Score = 37.4 bits (85), Expect = 0.030
Identities = 24/69 (34%), Positives = 36/69 (52%), Gaps = 4/69 (5%)
Query: 412 VCKVVEGTAAQSSGLRDHDVIVNINGKPITTTT--DVVKALDS--DSLSMAVLRGKDNLL 467
V K+ + A SGL + D +V+ING P T +V+K ++S DSL M + R +
Sbjct: 33 VAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPEVIKLMESITDSLQMLIKRPSSGIS 92
Query: 468 LTVIPETIN 476
+I E N
Sbjct: 93 EALISENEN 101
>gi|13376349 PDZ domain containing 7 [Homo sapiens]
Length = 517
Score = 37.0 bits (84), Expect = 0.039
Identities = 24/56 (42%), Positives = 33/56 (58%), Gaps = 3/56 (5%)
Query: 409 GVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTT--DVVKALDSDS-LSMAVLR 461
G++V KV EG++A+ +GL D I +NG + +TT VK L S S L M V R
Sbjct: 110 GIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRR 165
Score = 32.0 bits (71), Expect = 1.3
Identities = 19/62 (30%), Positives = 35/62 (56%), Gaps = 8/62 (12%)
Query: 409 GVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLL 468
G+YV KV G A+ +G++ D ++ NG D+ S S ++ VL+G+ +++L
Sbjct: 235 GIYVSKVDHGGLAEENGIKVGDQVLAANG---VRFDDI-----SHSQAVEVLKGQTHIML 286
Query: 469 TV 470
T+
Sbjct: 287 TI 288
>gi|30387656 late cornified envelope 1B [Homo sapiens]
Length = 118
Score = 37.0 bits (84), Expect = 0.039
Identities = 30/105 (28%), Positives = 37/105 (35%), Gaps = 20/105 (19%)
Query: 38 PSCPAVCQPTRCPALPTCALGTTPVFDLCRCCRV-----CPAAEREVCGGAQGQPCAPGL 92
P CP C RCP P C PV CC V C ++ CG + G C+ G
Sbjct: 18 PKCPPKCLTPRCP--PKCPPKCPPV---SSCCSVSSGGCCGSSSGGSCGSSSGGCCSSGG 72
Query: 93 Q--CLQP--------LRPGFPSTCGCPTLGGAVCGSDRRTYPSMC 127
CL RP C P+ G + CG + C
Sbjct: 73 GGCCLSHHRRRRSHCHRPQSSGCCSQPSGGSSCCGGGSGQHSGGC 117
>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
Length = 1066
Score = 37.0 bits (84), Expect = 0.039
Identities = 16/39 (41%), Positives = 27/39 (69%), Gaps = 1/39 (2%)
Query: 407 SSGVYVCKVVE-GTAAQSSGLRDHDVIVNINGKPITTTT 444
S G++V K+V+ G AA+ GL+ HD I+ +NG+ ++ T
Sbjct: 278 SEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRAT 316
>gi|225690576 keratin associated protein 2-2 [Homo sapiens]
Length = 123
Score = 36.6 bits (83), Expect = 0.051
Identities = 27/93 (29%), Positives = 32/93 (34%), Gaps = 16/93 (17%)
Query: 38 PSC--PAVCQPTRCPALPTCALGTTPVFDLCR---CCRVCPAAE---------REVCGGA 83
P C P CQ T C + T P+ + CR CC C E C
Sbjct: 28 PCCCRPVTCQTTVCRPVTCVPRCTRPICEPCRRPVCCDPCSLQEGCCRPITCCPSSCTAV 87
Query: 84 QGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVC 116
+PC C QP+ S CG PT C
Sbjct: 88 VCRPCCWATTCCQPV--SVQSPCGQPTPCSTTC 118
>gi|38202241 WNT1 inducible signaling pathway protein 3 isoform 3
[Homo sapiens]
Length = 372
Score = 36.6 bits (83), Expect = 0.051
Identities = 18/50 (36%), Positives = 23/50 (46%), Gaps = 1/50 (2%)
Query: 46 PTRCPAL-PTCALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQC 94
P +CP P C G + V D C CC++C E+C A GL C
Sbjct: 69 PCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYC 118
>gi|4507925 WNT1 inducible signaling pathway protein 3 isoform 1
[Homo sapiens]
Length = 354
Score = 36.6 bits (83), Expect = 0.051
Identities = 18/50 (36%), Positives = 23/50 (46%), Gaps = 1/50 (2%)
Query: 46 PTRCPAL-PTCALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQC 94
P +CP P C G + V D C CC++C E+C A GL C
Sbjct: 51 PCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYC 100
>gi|169211819 PREDICTED: keratin associated protein [Homo sapiens]
Length = 517
Score = 36.6 bits (83), Expect = 0.051
Identities = 36/155 (23%), Positives = 52/155 (33%), Gaps = 37/155 (23%)
Query: 41 PAVCQPTRCPALPTCALGTTPVFDLCRCCR-VCPAAEREVCGGAQG-----QPCAPGLQ- 93
P VC+P+ C A+ T PV CC+ VCP V Q PC P
Sbjct: 201 PVVCEPSCCSAVCTLPSSCQPVVCEPSCCQPVCPTPTCSVTSSCQAVCCDPSPCEPSCSE 260
Query: 94 -----------------CLQPL--------RPGFPSTCGCP-----TLGGAVCGSDRRTY 123
CL+P+ P PSTC P ++ +C
Sbjct: 261 SSICQPATCVALVCEPVCLRPVCCVQSSCEPPSVPSTCQEPSCCVSSICQPICSEPSPCS 320
Query: 124 PSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTR 158
P++C + + P+V + +C T R
Sbjct: 321 PAVCVSSPCQPTCYVVKRCPSVCPEPVSCPSTSCR 355
>gi|239745811 PREDICTED: hypothetical protein XP_002343557 [Homo
sapiens]
Length = 517
Score = 36.6 bits (83), Expect = 0.051
Identities = 36/155 (23%), Positives = 52/155 (33%), Gaps = 37/155 (23%)
Query: 41 PAVCQPTRCPALPTCALGTTPVFDLCRCCR-VCPAAEREVCGGAQG-----QPCAPGLQ- 93
P VC+P+ C A+ T PV CC+ VCP V Q PC P
Sbjct: 201 PVVCEPSCCSAVCTLPSSCQPVVCEPSCCQPVCPTPTCSVTSSCQAVCCDPSPCEPSCSE 260
Query: 94 -----------------CLQPL--------RPGFPSTCGCP-----TLGGAVCGSDRRTY 123
CL+P+ P PSTC P ++ +C
Sbjct: 261 SSICQPATCVALVCEPVCLRPVCCVQSSCEPPSVPSTCQEPSCCVSSICQPICSEPSPCS 320
Query: 124 PSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTR 158
P++C + + P+V + +C T R
Sbjct: 321 PAVCVSSPCQPTCYVVKRCPSVCPEPVSCPSTSCR 355
>gi|10834982 insulin-like growth factor binding protein 5 [Homo
sapiens]
Length = 272
Score = 36.2 bits (82), Expect = 0.067
Identities = 31/85 (36%), Positives = 40/85 (47%), Gaps = 10/85 (11%)
Query: 15 LLPGLLLLLVPVLWAG-AEKLHTQPSCPAVCQP--TRCPALPT-CALGTTPVFDLCRCCR 70
LL +LLLL +AG A+ L + C + + CP P C L P C CC
Sbjct: 3 LLTAVLLLLAA--YAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPG---CGCCM 57
Query: 71 VCPAAEREVCGGAQGQPCAPGLQCL 95
C AE + C G + CA GL+CL
Sbjct: 58 TCALAEGQSC-GVYTERCAQGLRCL 81
>gi|239752912 PREDICTED: hypothetical protein [Homo sapiens]
Length = 118
Score = 36.2 bits (82), Expect = 0.067
Identities = 29/105 (27%), Positives = 37/105 (35%), Gaps = 20/105 (19%)
Query: 38 PSCPAVCQPTRCPALPTCALGTTPVFDLCRCCRV-----CPAAEREVCGGAQGQPCAPGL 92
P CP C +CP P C PV CC V C ++ CG + G C+ G
Sbjct: 18 PKCPPKCPTPKCP--PKCPPKCPPV---SSCCSVSSGGCCGSSSGGSCGSSSGGCCSSGG 72
Query: 93 Q--CL--------QPLRPGFPSTCGCPTLGGAVCGSDRRTYPSMC 127
CL RP C P+ G + CG + C
Sbjct: 73 GGCCLSHHRHHRSHRHRPQSSDCCSQPSGGSSCCGGGSGQHSGGC 117
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,932,309
Number of Sequences: 37866
Number of extensions: 936814
Number of successful extensions: 2840
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 94
Number of HSP's that attempted gapping in prelim test: 2663
Number of HSP's gapped (non-prelim): 229
length of query: 476
length of database: 18,247,518
effective HSP length: 106
effective length of query: 370
effective length of database: 14,233,722
effective search space: 5266477140
effective search space used: 5266477140
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.