Search of human proteins with 24308167

Search of human proteins with 24308167

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24308167 SV2 related protein [Homo sapiens]
         (548 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24308167 SV2 related protein [Homo sapiens]                       1100   0.0  
gi|213021148 SVOP-like isoform 1 [Homo sapiens]                       364   e-100
gi|33457322 SVOP-like isoform 2 [Homo sapiens]                        239   6e-63
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   157   3e-38
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           152   6e-37
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          142   6e-34
gi|166064021 solute carrier family 22 (organic anion transporter...   140   4e-33
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   130   2e-30
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          130   3e-30
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       129   5e-30
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   129   5e-30
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   129   7e-30
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   129   7e-30
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           128   2e-29
gi|216548223 synaptic vesicle glycoprotein 2 [Homo sapiens]           125   1e-28
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   123   4e-28
gi|73695465 synaptic vesicle glycoprotein 2C [Homo sapiens]           123   4e-28
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       122   8e-28
gi|7662270 synaptic vesicle protein 2B homolog [Homo sapiens]         120   3e-27
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   105   1e-22
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   105   1e-22
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          105   1e-22
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          103   5e-22
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        101   2e-21
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          100   6e-21
gi|157426885 organic cation transporter like 4 [Homo sapiens]          98   2e-20
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]        82   1e-15
gi|153791484 putative UST1-like organic anion transporter [Homo ...    78   2e-14
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]        74   3e-13
gi|42542386 solute carrier family 22 (organic anion/cation trans...    73   6e-13

>gi|24308167 SV2 related protein [Homo sapiens]
          Length = 548

 Score = 1100 bits (2845), Expect = 0.0
 Identities = 548/548 (100%), Positives = 548/548 (100%)

Query: 1   MEEDLFQLRQLPVVKFRRTGESARSEDDTASGEHEVQIEGVHVGLEAVELDDGAAVPKEF 60
           MEEDLFQLRQLPVVKFRRTGESARSEDDTASGEHEVQIEGVHVGLEAVELDDGAAVPKEF
Sbjct: 1   MEEDLFQLRQLPVVKFRRTGESARSEDDTASGEHEVQIEGVHVGLEAVELDDGAAVPKEF 60

Query: 61  ANPTDDTFMVEDAVEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSW 120
           ANPTDDTFMVEDAVEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSW
Sbjct: 61  ANPTDDTFMVEDAVEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSW 120

Query: 121 QVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLR 180
           QVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLR
Sbjct: 121 QVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLR 180

Query: 181 GLVGFGIGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWL 240
           GLVGFGIGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWL
Sbjct: 181 GLVGFGIGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWL 240

Query: 241 LILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIISRQE 300
           LILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIISRQE
Sbjct: 241 LILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIISRQE 300

Query: 301 DRGKMRDLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAVEAK 360
           DRGKMRDLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAVEAK
Sbjct: 301 DRGKMRDLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAVEAK 360

Query: 361 CSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLLFIC 420
           CSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLLFIC
Sbjct: 361 CSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLLFIC 420

Query: 421 VGRNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQ 480
           VGRNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQ
Sbjct: 421 VGRNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQ 480

Query: 481 VMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQESSHREWGQEMVGRGMHGAGVT 540
           VMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQESSHREWGQEMVGRGMHGAGVT
Sbjct: 481 VMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQESSHREWGQEMVGRGMHGAGVT 540

Query: 541 RSNSGSQE 548
           RSNSGSQE
Sbjct: 541 RSNSGSQE 548


>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
          Length = 492

 Score =  364 bits (934), Expect = e-100
 Identities = 182/460 (39%), Positives = 286/460 (62%), Gaps = 7/460 (1%)

Query: 67  TFMVEDAVEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLT 126
           TF VEDAVE IGFG+F   L ++ G   + +AME+M++++++P + CEW+L +WQVAL+T
Sbjct: 31  TFTVEDAVETIGFGRFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVALVT 90

Query: 127 SVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFG 186
           ++VF G M  S L+G ++D+YGR   L IS LW  Y+ +L++FAP Y W + LR +VG G
Sbjct: 91  TMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCG 150

Query: 187 IGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLILSAV 246
           + G  Q + +  EFLP K R   + L +VFW  G++  + LA  ++P++GWRWL+ ++++
Sbjct: 151 VSGHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASI 210

Query: 247 PLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIISRQEDRGKMR 306
           P ++  V   ++PESAR++V +GN   A+ATL+R+A  N + MP GKL+    E RG+  
Sbjct: 211 PGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFA 270

Query: 307 DLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAV-------EA 359
           DL    +  TTL +W IW   +F+YYG++L + EL +   VCG  S    V       E+
Sbjct: 271 DLLDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGES 330

Query: 360 KCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLLFI 419
           +    C   +  DY  ++ +T+ E     + +  I+ LGR+ ++++     +   LLL I
Sbjct: 331 QSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNI 390

Query: 420 CVGRNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIA 479
           C     L   LF+ RA ++  F   Y+YT EVYPT  RALG+GT   + R+GA++ PFI+
Sbjct: 391 CTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFIS 450

Query: 480 QVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQE 519
           QV++ +S+   L ++S  C++ A+++  LPIETKGR LQ+
Sbjct: 451 QVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQ 490


>gi|33457322 SVOP-like isoform 2 [Homo sapiens]
          Length = 340

 Score =  239 bits (609), Expect = 6e-63
 Identities = 122/328 (37%), Positives = 195/328 (59%), Gaps = 7/328 (2%)

Query: 199 EFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLILSAVPLLLFAVLCFWL 258
           EFLP K R   + L +VFW  G++  + LA  ++P++GWRWL+ ++++P ++  V   ++
Sbjct: 11  EFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFI 70

Query: 259 PESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIISRQEDRGKMRDLFTPHFRWTTL 318
           PESAR++V +GN   A+ATL+R+A  N + MP GKL+    E RG+  DL    +  TTL
Sbjct: 71  PESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKYLRTTL 130

Query: 319 LLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAV-------EAKCSLACEYLSEE 371
            +W IW   +F+YYG++L + EL +   VCG  S    V       E++    C   +  
Sbjct: 131 QIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPS 190

Query: 372 DYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLLFICVGRNVLTLLLF 431
           DY  ++ +T+ E     + +  I+ LGR+ ++++     +   LLL IC     L   LF
Sbjct: 191 DYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLF 250

Query: 432 IARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTL 491
           + RA ++  F   Y+YT EVYPT  RALG+GT   + R+GA++ PFI+QV++ +S+   L
Sbjct: 251 MLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGAL 310

Query: 492 AVYSGCCLLAALASCFLPIETKGRGLQE 519
            ++S  C++ A+++  LPIETKGR LQ+
Sbjct: 311 CLFSSVCVVCAISAFTLPIETKGRALQQ 338


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  157 bits (396), Expect = 3e-38
 Identities = 124/411 (30%), Positives = 197/411 (47%), Gaps = 40/411 (9%)

Query: 119 SWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILV 178
           SW++ L  S +  G +  S   G  +D++GRK  L  +VL     G+L AF+P Y  +L+
Sbjct: 145 SWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLL 204

Query: 179 LRGLVGF-GIGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGW 237
            R L G    G      TL  EF+   +R    ++ ++ + +G V    LA + +P   W
Sbjct: 205 FRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLA-YALPH--W 261

Query: 238 RWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIIS 297
           RWL +  ++P  LF +  + +PES R+ +      +AI  +  IA +NG   P    ++S
Sbjct: 262 RWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLS 321

Query: 298 RQED-----RGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGIS 351
            +ED          DLF TP  R  T +L ++WF+++  Y GL+L        G   G  
Sbjct: 322 LEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLIL------HMGATSG-- 373

Query: 352 SRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIF- 410
                                Y+D L++ L E PG  + L  IDR+GR   MA+  ++  
Sbjct: 374 -------------------NLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAG 414

Query: 411 SFCSLLLFICVGRNVLTLLLF-IARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMAR 469
           + C +++FI    + L +++  + R  I+   Q   +   E+YPT  R LG+  CS +  
Sbjct: 415 AACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCD 474

Query: 470 VGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520
           +G +ITPFI   + E    L L +++   LLAA  +  LP ETKG  L E+
Sbjct: 475 IGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLP-ETKGVALPET 524


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  152 bits (385), Expect = 6e-37
 Identities = 121/416 (29%), Positives = 193/416 (46%), Gaps = 50/416 (12%)

Query: 119 SWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILV 178
           SW + L  S V VG    S   G I+D++GRK  L  +VL     G+L A +P Y+W+L+
Sbjct: 146 SWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLI 205

Query: 179 LR---GLV---GFGIGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVM 232
            R   GLV   G+ IG +     L  EF+  + R    +  +V + +G +   VLA    
Sbjct: 206 FRLIQGLVSKAGWLIGYI-----LITEFVGRRYRRTVGIFYQVAYTVGLL---VLAGVAY 257

Query: 233 PSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLG 292
               WRWL    A+P   F +  + +PES R+ +      +A+  +K IA +NG  +P  
Sbjct: 258 ALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPAS 317

Query: 293 KLIISRQEDRGKMRD------LFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGD 346
              +  +E+ GK  +      + TP  R  T++L + WF+++  Y GL++    +  AGD
Sbjct: 318 LQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIM---HMGLAGD 374

Query: 347 VCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALC 406
                                     Y+D  ++ L EFP   + +  IDR+GR+   A  
Sbjct: 375 ------------------------NIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAAS 410

Query: 407 -FVIFSFCSLLLFICVGRNVLTLLLF-IARAFISGGFQAAYVYTPEVYPTATRALGLGTC 464
             V  + C   +FI      L +++  + R  I+  ++   +   E+YPT  R LG+  C
Sbjct: 411 NMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHIC 470

Query: 465 SGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520
           S M  +G +ITPF+   +    + L L V+    L+A      LP ETKG+ L E+
Sbjct: 471 SSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLP-ETKGKALPET 525


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  142 bits (359), Expect = 6e-34
 Identities = 114/414 (27%), Positives = 191/414 (46%), Gaps = 57/414 (13%)

Query: 127 SVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFG 186
           S+   G++    + G++SD++GR+  L  S L     G  +AF+P +   +V R L GFG
Sbjct: 127 SIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFG 186

Query: 187 IGGVPQS-VTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLG-----WRWL 240
           I G+  S V L  E++P + RA     +   +  G         F++P L      WRWL
Sbjct: 187 ISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQ--------FILPGLAYAIPQWRWL 238

Query: 241 LILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIAT-----ENGAPMPLGKLI 295
            +  ++P  +F +  +W PES R+ VLSG   KA+  L+R+A      E G  + L +L 
Sbjct: 239 QLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELK 298

Query: 296 ISRQED------RGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVC 348
           ++ Q++      +    DLF  P  R  T  L   WF+  F+YY L +   E        
Sbjct: 299 LNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEF------- 351

Query: 349 GISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFV 408
           G++               Y+ +  +  +      + P   +T+  +  LGR  T A   +
Sbjct: 352 GVNL--------------YILQIIFGGV------DVPAKFITILSLSYLGRHTTQAAALL 391

Query: 409 IFSFCSL-LLFICVG-RNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSG 466
           +     L L F+ +  + V T+L    +  +S  F   ++YT E+YPT  R  G+G  + 
Sbjct: 392 LAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNL 451

Query: 467 MARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520
             RVG++++P + ++  E   ++   +Y    LL   A+ FLP ET  + L E+
Sbjct: 452 WTRVGSMVSPLV-KITGEVQPFIPNIIYGITALLGGSAALFLP-ETLNQPLPET 503


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  140 bits (352), Expect = 4e-33
 Identities = 107/401 (26%), Positives = 190/401 (47%), Gaps = 39/401 (9%)

Query: 127 SVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFG 186
           SV   G++  + ++G + D+ GRK  +   +L     G+ +AF P +   + LR  V   
Sbjct: 142 SVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATA 201

Query: 187 IGGVPQS-VTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLILSA 245
           + G+  S VTL  E++    R + ++L +  +++G   ++VLA        WR L I   
Sbjct: 202 VAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLG---QMVLAGLAYGFRNWRLLQITGT 258

Query: 246 VPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENG---APMPLGKLIISRQEDR 302
            P LL     + LPESAR+ +  G  ++AI  +++ A+ N    +P  + +L+  +    
Sbjct: 259 APGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPS 318

Query: 303 GKMRDLFT-PHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAVEAKC 361
           G   DLF  P  R  TL+++ +WF ++  YYGL L      Q GD               
Sbjct: 319 GNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSL------QVGD--------------- 357

Query: 362 SLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSF-CSLLLFIC 420
                    + Y+  L     E P    +++++ R GRK +     V+    C +++FI 
Sbjct: 358 ------FGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIP 411

Query: 421 VGRNVL-TLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIA 479
               V+ T+L  + +   +  F  +YVY+ E++PT  R  G+G     +R+G ++TP + 
Sbjct: 412 ADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVI 471

Query: 480 QVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520
            ++ E    L + +Y    ++A L    LP ET G+GL+++
Sbjct: 472 -LLGEYHAALPMLIYGSLPIVAGLLCTLLP-ETHGQGLKDT 510


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  130 bits (328), Expect = 2e-30
 Identities = 121/425 (28%), Positives = 185/425 (43%), Gaps = 52/425 (12%)

Query: 114 EWRLPSWQVAL---LTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFA 170
           EW L   Q  L    ++  F G++  +  +G +SD++GR+  L ++ + TL  G+ SA +
Sbjct: 131 EWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAAS 190

Query: 171 PVYSWILVLRGLVGFGIGGVPQSVT-LYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAV 229
             Y    + R L G  + G    V  L  E+L ++ R    +L   FW  G +   ++  
Sbjct: 191 VSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGY 250

Query: 230 FVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPM 289
            +     WRWLL+   +P     +  +W+PESAR+ +  G+ ++A   L   A  NG P+
Sbjct: 251 LIRD---WRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPV 307

Query: 290 --------PLGKLIIS-RQEDRGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTT 339
                    + K+    R   R    DLF TP  R  +L    +WF   FSYYGL L   
Sbjct: 308 CEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSL--- 364

Query: 340 ELFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGR 399
                 DV G+                      Y   L     E P  L+    +   GR
Sbjct: 365 ------DVSGLGLNV------------------YQTQLLFGAVELPSKLLVYLSVRYAGR 400

Query: 400 KKTMA--LCFVIFSFCSLLLFICVGRNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATR 457
           + T A  L     +F + LL     ++  T+L  + +AF    F  AY++T E+YPT  R
Sbjct: 401 RLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLR 460

Query: 458 ALGLGTCSGMARVGALITPFIAQVMLESSVYLTL--AVYSGCCLLAALASCFLPIETKGR 515
             G+G  + + R+G  + P  A   L   V+L+L    Y G  LLAA  +  LP ET+  
Sbjct: 461 QTGMGLTALVGRLGGSLAPLAA---LLDGVWLSLPKLTYGGIALLAAGTALLLP-ETRQA 516

Query: 516 GLQES 520
            L E+
Sbjct: 517 QLPET 521


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  130 bits (327), Expect = 3e-30
 Identities = 109/409 (26%), Positives = 187/409 (45%), Gaps = 38/409 (9%)

Query: 119 SWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILV 178
           +W + L  +++ +G ++ +   G  +D+YGR     +S L     G++ AFAP +   ++
Sbjct: 151 AWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVI 210

Query: 179 LRGLVG-FGIGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGW 237
            R L G FG G       +  E +  K R    ++I++F+ +G +    +A F+     W
Sbjct: 211 FRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIP---NW 267

Query: 238 RWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMP--LGKLI 295
           + + +   +P  LF +  + +PES R+ +     +KA+  L+RIA  NG  +     ++ 
Sbjct: 268 QGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEIT 327

Query: 296 ISRQE-DRGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSR 353
           ++ +E       DL  TP  R  TL+L F WF++A  Y GLV+      + G + G    
Sbjct: 328 VTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVM------RLGIIGG---- 377

Query: 354 KKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSF- 412
                              Y+D   + + E PG L+ L  I+RLGR+   A   ++    
Sbjct: 378 -----------------NLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVA 420

Query: 413 CSLLLFICVGRNVL-TLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVG 471
           C +  F+  G   L T +  + R  I+  F+  Y+   E+YPT  R  G+  CSG+   G
Sbjct: 421 CLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFG 480

Query: 472 ALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520
            +I PF+   +    + L L ++     +       LP ETKG  L E+
Sbjct: 481 GIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLP-ETKGIALPET 528


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  129 bits (325), Expect = 5e-30
 Identities = 111/412 (26%), Positives = 185/412 (44%), Gaps = 47/412 (11%)

Query: 124 LLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLV 183
           L  SV   G++  + ++G+++D+ G K  L  S L     G  +A+   +S   V R L+
Sbjct: 138 LAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAATAYFSSFSAYCVFRFLM 197

Query: 184 GFGIGGVP-QSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLI 242
           G    G+   SV+L  E++P + R    +L+   + +G +    +A  + P   WR L  
Sbjct: 198 GMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILAGVAYLIRP---WRCLQF 254

Query: 243 LSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMP---LGKLIISRQ 299
             + P L+F +  +WLPES+R+ +L G  + A+  L+++A  NG       L K ++S  
Sbjct: 255 AISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRKEEGERLTKEVMSSY 314

Query: 300 ED--------RGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGI 350
                        + DLF TP  R  T  L  IWFSN+ +YYGL +   +        G+
Sbjct: 315 IQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLAMDLQKF-------GL 367

Query: 351 SSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIF 410
           S                     Y+      +   P +LV    +  +GR+ T+A   ++ 
Sbjct: 368 SL--------------------YLVQALFGIINTPAMLVATATMIYVGRRATVASFLILA 407

Query: 411 SFCSLL-LFICVGRNVL-TLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMA 468
               +  +F+  G  +L T    + +  ++  F   Y++T E+YPT  R +G+G  S  A
Sbjct: 408 GLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHA 467

Query: 469 RVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520
           R+G L  P +   + E S  L    +    +LA LA C L  ET+   L E+
Sbjct: 468 RLGGLTAPLVT-TLGEYSTILPPVSFGATAILAGLAVCVL-TETRNMPLVET 517


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  129 bits (325), Expect = 5e-30
 Identities = 120/425 (28%), Positives = 185/425 (43%), Gaps = 52/425 (12%)

Query: 114 EWRLPSWQVAL---LTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFA 170
           +W L   Q  L    ++  F G++  +  +G +SD++GR+  L ++ + TL  G+ SA +
Sbjct: 133 QWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAAS 192

Query: 171 PVYSWILVLRGLVGFGIGGVPQSVT-LYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAV 229
             Y    + R L G  + G    V  L  E+L ++ R    +L   FW  G +   ++  
Sbjct: 193 VSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGY 252

Query: 230 FVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPM 289
            +     WRWLL+   +P     +  +W+PESAR+ +  G+ ++A   L   A  NG P+
Sbjct: 253 LIRD---WRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPV 309

Query: 290 --------PLGKLIIS-RQEDRGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTT 339
                    + K+    R   R    DLF TP  R  +L    +WF   FSYYGL L   
Sbjct: 310 CEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSL--- 366

Query: 340 ELFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGR 399
                 DV G+                      Y   L     E P  L+    +   GR
Sbjct: 367 ------DVSGLGLNV------------------YQTQLLFGAVELPSKLLVYLSVRYAGR 402

Query: 400 KKTMA--LCFVIFSFCSLLLFICVGRNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATR 457
           + T A  L     +F + LL     ++  T+L  + +AF    F  AY++T E+YPT  R
Sbjct: 403 RLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLR 462

Query: 458 ALGLGTCSGMARVGALITPFIAQVMLESSVYLTL--AVYSGCCLLAALASCFLPIETKGR 515
             G+G  + + R+G  + P  A   L   V+L+L    Y G  LLAA  +  LP ET+  
Sbjct: 463 QTGMGLTALVGRLGGSLAPLAA---LLDGVWLSLPKLTYGGIALLAAGTALLLP-ETRQA 518

Query: 516 GLQES 520
            L E+
Sbjct: 519 QLPET 523


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  129 bits (324), Expect = 7e-30
 Identities = 111/412 (26%), Positives = 189/412 (45%), Gaps = 47/412 (11%)

Query: 124 LLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLV 183
           L  S+  VG++  + ++G ++D+ GR+  L ++ L T   G  +AFAP +      R L 
Sbjct: 136 LAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLS 195

Query: 184 GFGIGGVP-QSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLI 242
           G  + G+    +TL  E++P+  RA    LI   +++G  F +    + +P   WR L +
Sbjct: 196 GMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQ-FLLAGVAYAVPH--WRHLQL 252

Query: 243 LSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIA-----TENGAPMPLGKLIIS 297
           L + P   F +  ++  ESAR+   SG  +  +  L+R+A      E GA + +  L  S
Sbjct: 253 LVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRAS 312

Query: 298 RQED--RGK-----MRDLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGI 350
            Q++   GK     M  L  P  R   L L  +WF+ +F+YYGLV+         D+ G 
Sbjct: 313 LQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM---------DLQG- 362

Query: 351 SSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIF 410
                                 Y+  +     + P  LV   +I+ LGR+       ++ 
Sbjct: 363 -----------------FGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLA 405

Query: 411 SFCSLLLFICVGRN--VLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMA 468
             C LL  +       V T L  + +  ++  F   ++YT E+YPT  R  G+G  S MA
Sbjct: 406 GICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMA 465

Query: 469 RVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520
           RVG++++P ++ +  E    + L +Y    + A+  +  LP ET G+ L ++
Sbjct: 466 RVGSIVSPLVS-MTAELYPSMPLFIYGAVPVAASAVTVLLP-ETLGQPLPDT 515


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  129 bits (324), Expect = 7e-30
 Identities = 111/412 (26%), Positives = 189/412 (45%), Gaps = 47/412 (11%)

Query: 124 LLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLV 183
           L  S+  VG++  + ++G ++D+ GR+  L ++ L T   G  +AFAP +      R L 
Sbjct: 136 LAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLS 195

Query: 184 GFGIGGVP-QSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLI 242
           G  + G+    +TL  E++P+  RA    LI   +++G  F +    + +P   WR L +
Sbjct: 196 GMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQ-FLLAGVAYAVPH--WRHLQL 252

Query: 243 LSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIA-----TENGAPMPLGKLIIS 297
           L + P   F +  ++  ESAR+   SG  +  +  L+R+A      E GA + +  L  S
Sbjct: 253 LVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRAS 312

Query: 298 RQED--RGK-----MRDLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGI 350
            Q++   GK     M  L  P  R   L L  +WF+ +F+YYGLV+         D+ G 
Sbjct: 313 LQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM---------DLQG- 362

Query: 351 SSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIF 410
                                 Y+  +     + P  LV   +I+ LGR+       ++ 
Sbjct: 363 -----------------FGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLA 405

Query: 411 SFCSLLLFICVGRN--VLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMA 468
             C LL  +       V T L  + +  ++  F   ++YT E+YPT  R  G+G  S MA
Sbjct: 406 GICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMA 465

Query: 469 RVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520
           RVG++++P ++ +  E    + L +Y    + A+  +  LP ET G+ L ++
Sbjct: 466 RVGSIVSPLVS-MTAELYPSMPLFIYGAVPVAASAVTVLLP-ETLGQPLPDT 515


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  128 bits (321), Expect = 2e-29
 Identities = 106/413 (25%), Positives = 189/413 (45%), Gaps = 50/413 (12%)

Query: 114 EWRL---PSWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFA 170
           EW L     W+  L  S+ FVG++  S + G +SD++GRK  L +++     +  L  F+
Sbjct: 131 EWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFS 190

Query: 171 PVYSWILVLRGLVGFG-IGGVPQSVTLYAEFLPMKARAKCILL-IEVFWAIGTVFEVVLA 228
             +   +VL  LVG G I     +  L  E L    R     L + +F+A G +   + A
Sbjct: 191 KNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFA 250

Query: 229 VFVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAP 288
            F+     WR LL+   +P +L   L +++PES R+ +  G  E+A   +++ A  NG  
Sbjct: 251 YFIRD---WRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIV 307

Query: 289 MP--------LGKLIISRQEDRGKMRDLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTE 340
           +P        L  L   +Q+    +  L T + R  T++   +W + +  Y+GL L T  
Sbjct: 308 VPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPN 367

Query: 341 LFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRK 400
           L   GD+                         +++   + + E P  ++   ++  L R+
Sbjct: 368 LH--GDI-------------------------FVNCFLSAMVEVPAYVLAWLLLQYLPRR 400

Query: 401 KTMALCFVIFSFCSLLLFICVGRNVL----TLLLFIARAFISGGFQAAYVYTPEVYPTAT 456
            +MA    +F   S+LLF+ +    L    T+L+ + +  ++  F   YVYT E+YPT  
Sbjct: 401 YSMATA--LFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVV 458

Query: 457 RALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLP 509
           R +G+G  S  +R+G++++P+   +      +L   +     +L A+ + FLP
Sbjct: 459 RNMGVGVSSTASRLGSILSPYFVYLGAYDR-FLPYILMGSLTILTAILTLFLP 510


>gi|216548223 synaptic vesicle glycoprotein 2 [Homo sapiens]
          Length = 742

 Score =  125 bits (314), Expect = 1e-28
 Identities = 89/333 (26%), Positives = 147/333 (44%), Gaps = 48/333 (14%)

Query: 71  EDAVEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVF 130
           E  +   G G+FQW L  + GLA MAD +E+ ++  + P    +  L      +L  +V+
Sbjct: 153 EAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVY 212

Query: 131 VGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFGIGG- 189
           +GMM  + LWG ++D+ GR+  L IS+     +   S+F   Y   L  R L G GIGG 
Sbjct: 213 LGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGS 272

Query: 190 VPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLG------------- 236
           +P   + ++EFL  + R + +  + +FW IG V+   +A  ++P  G             
Sbjct: 273 IPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHS 332

Query: 237 WRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATEN----GAP---M 289
           WR  +++ A P +         PES R+ + +G  ++A   LK++   N    G P    
Sbjct: 333 WRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVF 392

Query: 290 PLGKLIISRQEDR---------------------------GKMRDLFTPHFRWTTLLLWF 322
            +  +    QED                            G     F P +R  TL++  
Sbjct: 393 SVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMG 452

Query: 323 IWFSNAFSYYGLVLLTTELFQAGDVCGISSRKK 355
           +WF+ +FSYYGL +   ++ +       +SR K
Sbjct: 453 VWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTK 485



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 33/144 (22%), Positives = 62/144 (43%), Gaps = 11/144 (7%)

Query: 380 TLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLLFICVGRNVLTLLLFIARAFISG 439
           TL+  PG +V+  ++D++GR + +A   V+       L      + +  LL +       
Sbjct: 605 TLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIA 664

Query: 440 GFQAAYVYTPEVYPTATRALGLGTCSGMARVGALI-----TPFIAQVMLESSVYLTLAVY 494
            + A  V T E+YP+  R    G  + + ++ A++     T F+        ++ + A+ 
Sbjct: 665 SWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALA 724

Query: 495 SGCCLLAALASCFLPIETKGRGLQ 518
            G  L   L       ET+G+ LQ
Sbjct: 725 LGSSLALKLP------ETRGQVLQ 742


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  123 bits (309), Expect = 4e-28
 Identities = 99/351 (28%), Positives = 163/351 (46%), Gaps = 39/351 (11%)

Query: 119 SWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILV 178
           SW++ L  S +  G +  S   G  +D++GRK  L  +VL     G+L AF+P Y  +L+
Sbjct: 145 SWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLL 204

Query: 179 LRGLVGF-GIGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGW 237
            R L G    G      TL  EF+   +R    ++ ++ + +G V    LA + +P   W
Sbjct: 205 FRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLA-YALPH--W 261

Query: 238 RWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIIS 297
           RWL +  ++P  LF +  + +PES R+ +      +AI  +  IA +NG   P    ++S
Sbjct: 262 RWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLS 321

Query: 298 RQED-----RGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGIS 351
            +ED          DLF TP  R  T +L ++WF+++  Y GL+L        G   G  
Sbjct: 322 LEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLIL------HMGATSG-- 373

Query: 352 SRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIF- 410
                                Y+D L++ L E PG  + L  IDR+GR   MA+  ++  
Sbjct: 374 -------------------NLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAG 414

Query: 411 SFCSLLLFICVGRNVLTLLLF-IARAFISGGFQAAYVYTPEVYPTATRALG 460
           + C +++FI    + L +++  + R  I+   Q   +   E+YPT    +G
Sbjct: 415 AACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVG 465


>gi|73695465 synaptic vesicle glycoprotein 2C [Homo sapiens]
          Length = 727

 Score =  123 bits (309), Expect = 4e-28
 Identities = 86/309 (27%), Positives = 142/309 (45%), Gaps = 48/309 (15%)

Query: 74  VEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFVGM 133
           ++  G G+FQW L  + G+A MAD +E+ ++  + P    +  +P+     L S+V++GM
Sbjct: 142 IQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGM 201

Query: 134 MSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFGIGG-VPQ 192
           M  +  WG ++D+ GRK  L I +    ++  LS+F   Y + L  R L GFGIGG +P 
Sbjct: 202 MVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPT 261

Query: 193 SVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLG-------------WRW 239
             + +AE L  + R + +  + +FW IG ++   +A  ++P  G             WR 
Sbjct: 262 VFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRV 321

Query: 240 LLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATEN----GAP---MPLG 292
            +I+ A+P +   V   ++PES R+ +  G  ++A   LK I   N    G P     + 
Sbjct: 322 FVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVN 381

Query: 293 KL--------IISRQEDRG-------------------KMRDLFTPHFRWTTLLLWFIWF 325
           K+        +I  + D G                        F    R  T+ L  +WF
Sbjct: 382 KIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWF 441

Query: 326 SNAFSYYGL 334
           + +F YYGL
Sbjct: 442 TLSFGYYGL 450



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 32/152 (21%), Positives = 64/152 (42%), Gaps = 8/152 (5%)

Query: 365 CEYLSEEDYMDLLWT-------TLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLL 417
           C+   ++DY    W        TL+  PG +V+  ++DR+GR   +    V+       L
Sbjct: 569 CQITFDDDY-SAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFL 627

Query: 418 FICVGRNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPF 477
           +     +++  +L +        + +  V T E+YPT  RA G G  + + +  A++   
Sbjct: 628 WFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNL 687

Query: 478 IAQVMLESSVYLTLAVYSGCCLLAALASCFLP 509
           I   ++  +  + + + S   +   L    LP
Sbjct: 688 IFGSLVSITKSIPILLASTVLVCGGLVGLCLP 719


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  122 bits (306), Expect = 8e-28
 Identities = 126/445 (28%), Positives = 189/445 (42%), Gaps = 67/445 (15%)

Query: 114 EWRL---PSWQVALLTSVVFVGMMSSSTLWGNISDQYGRK----TGLKISVLWTLYYGIL 166
           EW L    S++V+  +S  F G+      +G +SD++GRK    TG  + +L    + I 
Sbjct: 100 EWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDIL----FAIA 155

Query: 167 SAFAPVYSWILVLRGLVGFGIGGVPQ-SVTLYAEFLPMKARAKCILLIEVFWAIGTVFEV 225
           + F+P Y +  V R LVG   GG+   +  L  E +     A    +  +F+A+G     
Sbjct: 156 NGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYA 215

Query: 226 VLAVFVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATEN 285
           +L  F+     WR L IL  +   +  +L  ++PES R+    G   +A   L  IA  N
Sbjct: 216 LLGYFIR---SWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRN 272

Query: 286 G---APMPLGKLIISRQEDRGKMRDLFTPH-FRWTTLLLWFIWFSNAFSYYGLVLLTTEL 341
                   L         + G   DLF        TL+L FIWF  +  YYGL L     
Sbjct: 273 RKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTL----- 327

Query: 342 FQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDR--LGR 399
             AGD+ G                       Y +L  + L E P   + +++I++   GR
Sbjct: 328 -SAGDLGG---------------------SIYANLALSGLIEIPSYPLCIYLINQKWFGR 365

Query: 400 KKTMALCFVIFSFCSLLL-----------FICVGRNVLTLLLFIARAFISGGFQAAYVYT 448
           K+T++    +     L++           F  V  + L+LL    +  IS  F   Y+YT
Sbjct: 366 KRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLL---GKLTISAAFNIVYIYT 422

Query: 449 PEVYPTATRALGLGTCSGMARVGALITPFI-----AQVMLESSVYLTLAVYSGCCLLAAL 503
            E+YPT  R +GLGTCS  +RVG +I PFI      Q  L   V+    + SG   L   
Sbjct: 423 SELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLP 482

Query: 504 ASCFLPIETKGRGLQESSHREWGQE 528
            +   P+      LQ  S+R  G+E
Sbjct: 483 ETLNSPLLETFSDLQVYSYRRLGEE 507


>gi|7662270 synaptic vesicle protein 2B homolog [Homo sapiens]
          Length = 683

 Score =  120 bits (301), Expect = 3e-27
 Identities = 86/314 (27%), Positives = 146/314 (46%), Gaps = 48/314 (15%)

Query: 71  EDAVEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVF 130
           E  ++  G G+FQW L  + GLA MAD +E+ ++S   P    +  L S +  +L  +V+
Sbjct: 96  ETIMDECGHGRFQWILFFVLGLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVY 155

Query: 131 VGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFGIGG- 189
           +GMM+ + + G ++D+ GRK  L +S+     +  LS+F   Y   L  R + G GIGG 
Sbjct: 156 LGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGA 215

Query: 190 VPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLG------------- 236
           +P     ++EFL  + R + +  + +FW  G ++   +A  ++P  G             
Sbjct: 216 LPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHS 275

Query: 237 WRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATEN----GAPMPLG 292
           WR  +I+ A+P  +  V   ++PES R+ +  G  ++A   LK++   N    G P  + 
Sbjct: 276 WRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVF 335

Query: 293 KL-----------IISRQEDRG--------KMRDLFTP-----------HFRWTTLLLWF 322
            +            I  Q   G        + + +F              +R  TL+L  
Sbjct: 336 TVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAV 395

Query: 323 IWFSNAFSYYGLVL 336
           +WF+ AFSYYGL +
Sbjct: 396 VWFAMAFSYYGLTV 409



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 33/118 (27%), Positives = 56/118 (47%), Gaps = 2/118 (1%)

Query: 380 TLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLLFICVGRNVLTLLLFIARAFISG 439
           +LS  PG +++  ++DR+GR K +    +I + C   LF     + +     +       
Sbjct: 546 SLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIA 605

Query: 440 GFQAAYVYTPEVYPTATRALGLGTCSGMARVGALI--TPFIAQVMLESSVYLTLAVYS 495
            + A  V T E+YPT  RA   G  +G+ + GA++  T F + V +   V + LA  S
Sbjct: 606 AWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAAS 663


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  105 bits (262), Expect = 1e-22
 Identities = 93/351 (26%), Positives = 156/351 (44%), Gaps = 45/351 (12%)

Query: 124 LLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLV 183
           L  S+  VG++  + ++G ++D+ GR+  L ++ L T   G  +AFAP +      R L 
Sbjct: 136 LAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLS 195

Query: 184 GFGIGGVP-QSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLI 242
           G  + G+    +TL  E++P+  RA    LI   +++G  F +    + +P   WR L +
Sbjct: 196 GMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQ-FLLAGVAYAVPH--WRHLQL 252

Query: 243 LSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIA-----TENGAPMPLGKLIIS 297
           L + P   F +  ++  ESAR+   SG  +  +  L+R+A      E GA + +  L  S
Sbjct: 253 LVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRAS 312

Query: 298 RQED--RGK-----MRDLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGI 350
            Q++   GK     M  L  P  R   L L  +WF+ +F+YYGLV+         D+ G 
Sbjct: 313 LQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM---------DLQG- 362

Query: 351 SSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIF 410
                                 Y+  +     + P  LV   +I+ LGR+       ++ 
Sbjct: 363 -----------------FGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLA 405

Query: 411 SFCSLLLFICVGRN--VLTLLLFIARAFISGGFQAAYVYTPEVYPTATRAL 459
             C LL  +       V T L  + +  ++  F   ++YT E+YPT  RA+
Sbjct: 406 GICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRAV 456


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  105 bits (262), Expect = 1e-22
 Identities = 93/351 (26%), Positives = 156/351 (44%), Gaps = 45/351 (12%)

Query: 124 LLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLV 183
           L  S+  VG++  + ++G ++D+ GR+  L ++ L T   G  +AFAP +      R L 
Sbjct: 136 LAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLS 195

Query: 184 GFGIGGVP-QSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLI 242
           G  + G+    +TL  E++P+  RA    LI   +++G  F +    + +P   WR L +
Sbjct: 196 GMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQ-FLLAGVAYAVPH--WRHLQL 252

Query: 243 LSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIA-----TENGAPMPLGKLIIS 297
           L + P   F +  ++  ESAR+   SG  +  +  L+R+A      E GA + +  L  S
Sbjct: 253 LVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRAS 312

Query: 298 RQED--RGK-----MRDLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGI 350
            Q++   GK     M  L  P  R   L L  +WF+ +F+YYGLV+         D+ G 
Sbjct: 313 LQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM---------DLQG- 362

Query: 351 SSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIF 410
                                 Y+  +     + P  LV   +I+ LGR+       ++ 
Sbjct: 363 -----------------FGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLA 405

Query: 411 SFCSLLLFICVGRN--VLTLLLFIARAFISGGFQAAYVYTPEVYPTATRAL 459
             C LL  +       V T L  + +  ++  F   ++YT E+YPT  RA+
Sbjct: 406 GICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRAV 456


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  105 bits (262), Expect = 1e-22
 Identities = 108/424 (25%), Positives = 185/424 (43%), Gaps = 53/424 (12%)

Query: 114 EWRL---PSWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFA 170
           EW L    +W+V L TS+ FVG++  S + G +SD++GRK  L  ++     +  L  F+
Sbjct: 131 EWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFS 190

Query: 171 PVYSWILVLRGLVGFG-IGGVPQSVTLYAEFLPMKARAKCILL-IEVFWAIGTVFEVVLA 228
             +    VL  +VG G I     +  L  E L    R     L +  F+A+G +   + A
Sbjct: 191 ISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFA 250

Query: 229 VFVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAP 288
            F+     WR LL+   VP +L   L +++PES R+ +      +A   +++ A  N   
Sbjct: 251 YFIRD---WRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIA 307

Query: 289 MPLGKLIISRQEDRGKMR-------DLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTE 340
           +P   +I    E+   ++       DLF T +    T++   +W   +  Y+ L      
Sbjct: 308 VPA--VIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFAL------ 359

Query: 341 LFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRK 400
                                SL    L  + Y++   + L E P  +    ++  L R+
Sbjct: 360 ---------------------SLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRR 398

Query: 401 KTMALCFVIFSFCSLLLFIC---VGRNVLTL-LLFIARAFISGGFQAAYVYTPEVYPTAT 456
             +A   V+F    +LLFI    V    L++ L+ + +  I+  F   YV+T E+YPT  
Sbjct: 399 YIIAA--VLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLV 456

Query: 457 RALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRG 516
           R + +G  S  +RVG++I P+   +   + + L   V     +L  + + F P E+ G  
Sbjct: 457 RNMAVGVTSTASRVGSIIAPYFVYLGAYNRM-LPYIVMGSLTVLIGILTLFFP-ESLGMT 514

Query: 517 LQES 520
           L E+
Sbjct: 515 LPET 518


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  103 bits (256), Expect = 5e-22
 Identities = 103/450 (22%), Positives = 187/450 (41%), Gaps = 51/450 (11%)

Query: 105 SILAPQLHCEWRLPSWQVAL---LTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTL 161
           SI    +  +W L     AL     S+   G++  +   G  SD++GR+  L  S L   
Sbjct: 125 SIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMA 184

Query: 162 YYGILSAFAPVYSWILVLRGLVGFGIGGVPQSV-TLYAEFLPMKARAKCILLIEVFWAIG 220
             G  +AFAP +    + R L+ F + GV  +  TL  E+   +AR   + L  + ++ G
Sbjct: 185 VMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFG 244

Query: 221 TVFEVVLAVFVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKR 280
                 +A  V     W  L ++ +VP  L  +  +WL ESAR+ + +G  +  +  L R
Sbjct: 245 HGLTAAVAYGVRD---WTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWR 301

Query: 281 IATENGAPMPLGKL----IISRQEDRGKMRD--------LFTPHFRWTTLLLWFIWFSNA 328
           +A  NG       L    ++S   +   M          L  P  R+ T +    WF+  
Sbjct: 302 VAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFG 361

Query: 329 FSYYGLVLLTTELFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVL 388
           F+++GL                           +L  + L    ++  ++  + + P  +
Sbjct: 362 FTFFGL---------------------------ALDLQALGSNIFLLQMFIGVVDIPAKM 394

Query: 389 VTLWIIDRLGRKKTMALCFVIFSFCSLLLFICVGRN--VLTLLLFIARAFISGGFQAAYV 446
             L ++  LGR+ T+A   ++   C L   +       + + L  +    +   F    +
Sbjct: 395 GALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITI 454

Query: 447 YTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASC 506
           Y+ E++PT  R   +G     AR GA++ P + +++     +L L VY    +L+ LA+ 
Sbjct: 455 YSSELFPTVLRMTAVGLGQMAARGGAILGPLV-RLLGVHGPWLPLLVYGTVPVLSGLAAL 513

Query: 507 FLPIETKGRGLQESSHREWGQEMVGRGMHG 536
            LP ET+   L ++  ++   + V +  HG
Sbjct: 514 LLP-ETQSLPLPDTI-QDVQNQAVKKATHG 541


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  101 bits (251), Expect = 2e-21
 Identities = 102/425 (24%), Positives = 183/425 (43%), Gaps = 56/425 (13%)

Query: 114 EWRLP---SWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFA 170
           +W L     W   L+  +   G++  S  +G  SD+ GR+  L  +      +GI +AFA
Sbjct: 143 QWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFA 202

Query: 171 PVYSWILVLRGLVGFGIGGVPQSVTLYA-EFLPMKARAKCILLIEVFWAIGTVFEVVLAV 229
             Y   +  R  +     G      +Y  EF+ MK+R    + +  F+A+GT+   +   
Sbjct: 203 VDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGY 262

Query: 230 FVMPSLGWRWLLILSAVPLLLFAVLCFW-LPESARYDVLSGNQEKAIATLKRIATENGAP 288
            V     W + +ILS V +    +LC W LPE+  + +  G  E+A   +  +A  N A 
Sbjct: 263 LVRT--WWLYQMILSTVTVPF--ILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRAS 318

Query: 289 M-PLGKLI-------ISRQEDRGKMRDLFTPHFRWT----TLLLWFIWFSNAFSYYGLVL 336
              L +L+       +S      +  +L    + W+    TL +W IWF+ +  +Y    
Sbjct: 319 SCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSF-- 376

Query: 337 LTTELFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDR 396
                                    SL    L   +Y++L    + E P        +D+
Sbjct: 377 -------------------------SLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDK 411

Query: 397 LGRKKTMALCFVIFSF-CSLLLFICVGRNVLTLLLFIARAF-ISGGFQAAYVYTPEVYPT 454
           +GR+  +A      +  C +++ I     +L ++  +   F I   F   Y+YT E+YPT
Sbjct: 412 VGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPT 471

Query: 455 ATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTL-AVYSG-CCLLAALASCFLPIET 512
             R+L +G+ S + R+ +++ PF   +   SS+++ +  ++ G   LL+ + +  LP ET
Sbjct: 472 IVRSLAVGSGSMVCRLASILAPFSVDL---SSIWIFIPQLFVGTMALLSGVLTLKLP-ET 527

Query: 513 KGRGL 517
            G+ L
Sbjct: 528 LGKRL 532


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 98/412 (23%), Positives = 176/412 (42%), Gaps = 47/412 (11%)

Query: 124 LLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLV 183
           L  S+   G++  S +WG +S ++GRK  L    L     G  + FAP +     LR + 
Sbjct: 144 LSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVA 203

Query: 184 GFGIGGV-PQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLI 242
            FG+ G+   S+TL  E+     RA  + ++   ++ G   +  L         WR L +
Sbjct: 204 AFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAG---QAALGGLAFALRDWRTLQL 260

Query: 243 LSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENG----------APMPLG 292
            ++VP    +++ +WLPESAR+ ++ G  ++A+  L+++A  NG            M   
Sbjct: 261 AASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSV 320

Query: 293 KLIISRQEDRGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGIS 351
           K  ++  ++   + DLF  P  RW +  +  + FS   SYYGLV     L    D+  + 
Sbjct: 321 KEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSL--GRDIFLLQ 378

Query: 352 SRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFS 411
           +   AV                         +F G   T  ++  LGR +T+       +
Sbjct: 379 ALFGAV-------------------------DFLGRATTALLLSFLGR-RTIQAGSQAMA 412

Query: 412 FCSLLLFICVGRNVLTLLLFIA---RAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMA 468
             ++L  + V +++ TL +  A   +           +Y  E++PT  R    G    + 
Sbjct: 413 GLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVG 472

Query: 469 RVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520
           R+GA++ P I  +  ++   L   +Y    + ++L   F   ET+G  L ++
Sbjct: 473 RLGAMMGPLIL-MSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDT 523


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 107/416 (25%), Positives = 194/416 (46%), Gaps = 65/416 (15%)

Query: 132 GMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLR-GLVGFGIGGV 190
           G+   S ++  I+D+ GR   + +S+L  + +G  +AF   +   L  R G+    +G  
Sbjct: 193 GLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYA 252

Query: 191 PQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLILSAVPLLL 250
             S++L  E+L  + RA  I+L   F+A+G V    +A + +P   W+ L ++  + ++ 
Sbjct: 253 ISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIA-YSLPH--WQLLFLVGGILVIP 309

Query: 251 FAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMP---LGKLIISRQE-DRGKMR 306
           F    + LPES R+ ++ G  ++A   L   A+ N   +P   L +L + R++  R  + 
Sbjct: 310 FISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDELQLPRKKVTRASVL 369

Query: 307 DLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAVEAKCSLAC 365
           D          TL++  +WF+ +++Y+ L L   EL       G+S   + V        
Sbjct: 370 DFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMREL-------GVSVHFRHVV------- 415

Query: 366 EYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFV-IFSFCSLLLFICVGRN 424
                         ++ E P  L  ++++ ++GRK ++A+  +    +C LLLF+  G +
Sbjct: 416 -------------PSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGED 462

Query: 425 VL---------------TLLLFIARAF-ISGGFQAAYVYTPEVYPTATRALGLGTCSGMA 468
            L               T+L+ + R F ++      ++YT E+ PT  RA GLG  S  +
Sbjct: 463 GLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLAS 522

Query: 469 RVGALIT-PFIAQVMLESSVYLTLAVYSGCCLLAALA---SCFLPIETKGRGLQES 520
             GA+++   I+Q      ++L       CC+LA +A   S  LP ET+ + L ES
Sbjct: 523 VAGAILSLTIISQTPSLLPIFL-------CCVLAIVAFSLSSLLP-ETRDQPLSES 570


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 92/409 (22%), Positives = 178/409 (43%), Gaps = 49/409 (11%)

Query: 128 VVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFGI 187
           ++  GM+    + G++SD++GR+  L+  +L        +AFAP +    VLR L GF  
Sbjct: 151 LLLTGMLVGGIIGGHVSDRFGRRFILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSS 210

Query: 188 GGVPQSVTL-YAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLILSAV 246
             +  + +L   E++   ++A  ++L     +IG   +++L         W+ L ++++V
Sbjct: 211 MIIISNNSLPITEWIRPNSKALVVILSSGALSIG---QIILGGLAYVFRDWQTLHVVASV 267

Query: 247 PLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLII-----SRQED 301
           P  +F +L  WL ESAR+ +++   ++ +  L+++A  NG       L I     + QE+
Sbjct: 268 PFFVFFLLSRWLVESARWLIITNKLDEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEE 327

Query: 302 ------RGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRK 354
                 +  + DLF  P  R    +L F+ F+N   +YG ++    +     +  +    
Sbjct: 328 LDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGA 387

Query: 355 KAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCS 414
            A+  +C                           + L  ++ +GR+ +  L F+     S
Sbjct: 388 VALIVRC---------------------------LALLTLNHMGRRISQIL-FMFLVGLS 419

Query: 415 LLLFICVGRNVLTLLLFIARAFI---SGGFQAAYVYTPEVYPTATRALGLGTCSGMARVG 471
           +L    V + + TL + +A   I   +  F +  V+  E+ PT  RA   G     +R+G
Sbjct: 420 ILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIG 479

Query: 472 ALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520
           A + P +  + +  +  L   +Y    ++  L    LP ETK   L ++
Sbjct: 480 AALAPLLMTLTVFFTT-LPWIIYGIFPIIGGLIVFLLP-ETKNLPLPDT 526


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 112/475 (23%), Positives = 188/475 (39%), Gaps = 80/475 (16%)

Query: 83  QWKLSVLTGL--------------AWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSV 128
           QWKL  L G                W+ D        +    L CE + P   VA    +
Sbjct: 95  QWKLIHLNGTFPNTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQ-PLNSVAKF--L 151

Query: 129 VFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAP---VYSWILVLRGLVGF 185
              GMM    L+G++SD++GRK  L+ S L     G  +AFAP   VY  +  L G   F
Sbjct: 152 FMAGMMVGGNLYGHLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATF 211

Query: 186 GIGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLILSA 245
            I  +  +V L  E++  +  A  + L     +IG +    LA  +        L ++ +
Sbjct: 212 SI--IVNTVLLIVEWITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQC---ILQLVMS 266

Query: 246 VPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIISRQEDRGKM 305
            P  +F +   WL ESAR+ +++   E+ +  L++ A  NG  M   + I++ +  +  M
Sbjct: 267 APCFVFFLFSRWLAESARWLIINNKPEEGLKELRKAAHRNG--MKNAEDILTMEVLKSTM 324

Query: 306 RD--------------LFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGIS 351
           +               L  P+       L F+ F++   ++GL L    L    +V  + 
Sbjct: 325 KQELEAAQKKHSLCELLRIPNICKRICFLSFVRFASTIPFWGLTLHLQHL--GNNVFLLQ 382

Query: 352 SRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFS 411
           +   AV                     T L+      V  W ++ + R+ +  L   + +
Sbjct: 383 TLFGAV---------------------TLLAN----CVAPWALNHMSRRLSQMLLMFLLA 417

Query: 412 FCSLLLFICVGRNVLTLLLFIARAFI---SGGFQAAYVYTPEVYPTATRALGLGTCSGMA 468
            C LL  I V + + TL + +A   +   S G   +     E+ P+  R    G     A
Sbjct: 418 TC-LLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFA 476

Query: 469 RVGALITPFIAQVMLESSVY---LTLAVYSGCCLLAALASCFLPIETKGRGLQES 520
            +G      +A +M+  S+Y   L   +Y    +L+ L    LP ET+ + L +S
Sbjct: 477 NIGGA----LASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLP-ETRNQPLLDS 526


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 89/431 (20%), Positives = 176/431 (40%), Gaps = 49/431 (11%)

Query: 94  WMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGL 153
           W+ D    +   +    L CE +      +++ S+   G +    ++G++SD+ GRK   
Sbjct: 120 WVYDRSSFLSTIVTEWDLVCESQSLK---SMVQSLFMAGSLLGGLIYGHLSDRVGRKIIC 176

Query: 154 KISVLWTLYYGILSAFAPVYSWILVLRGLVGFGIGGV-PQSVTLYAEFLPMKARAKCILL 212
           K+  L        +AFAP +    +LR L GF    +   +  L  E+   ++R+  I++
Sbjct: 177 KLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMV 236

Query: 213 IEVFWAIGTVFEVVLAVFVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQE 272
           +   +++G   +++L         W  L +  + P+++  +  + + ESAR+ +++   +
Sbjct: 237 LLCSYSVG---QMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLD 293

Query: 273 KAIATLKRIA-------TENGAPMPLGKLIISRQEDRGKMR----DLF-TPHFRWTTLLL 320
           + +  L+R+A       TE      L +  + ++ D  +++     LF  P  R     L
Sbjct: 294 EGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGL 353

Query: 321 WFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTT 380
            F+ F+    +YGL+L    L     +  I        A+C                   
Sbjct: 354 CFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARC------------------- 394

Query: 381 LSEFPGVLVTLWIIDRLGRKKTMAL-CFVIFSFCSLLLFICVGRNVLTLLL-FIARAFIS 438
                   V+L  ++ +GR+ +  L  F +  F  +  F+     +L ++L  +    +S
Sbjct: 395 --------VSLLTLNHMGRRISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVS 446

Query: 439 GGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCC 498
               +A V+  E+ PT  R+   G  +   R GA + P +  +M  S  +L    Y    
Sbjct: 447 AASNSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSP-HLPWISYGVFP 505

Query: 499 LLAALASCFLP 509
           +LA      LP
Sbjct: 506 ILAVPVILLLP 516


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 100/440 (22%), Positives = 176/440 (40%), Gaps = 71/440 (16%)

Query: 114 EWRLPSWQVALLTSVVFV---GMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFA 170
           EW L     +L +   FV   GMM    L G++SD++GR+  L+   L     G  +A A
Sbjct: 134 EWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALA 193

Query: 171 PVYSWILVLRGLVGF-GIGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAV 229
           P +     LR L G   +  +  ++ L AE+   + +A  I L       G  F + LA 
Sbjct: 194 PTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITL--GMCPSGIAF-MTLAG 250

Query: 230 FVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENG--- 286
                  W  L ++ +VP  +  +   WL ESAR+ +++   E+ +  L++ A  +G   
Sbjct: 251 LAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKN 310

Query: 287 ----APMPLGKLIISRQEDRGKMRD------LFTPHFRWTTLLLWFIWFSNAFSYYGLVL 336
                 + + K  + ++ +  + +       L  P+      LL F  F+N  +Y+GL  
Sbjct: 311 ARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGL-- 368

Query: 337 LTTELFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTL----- 391
                                    +L  ++L    ++      L    G ++ L     
Sbjct: 369 -------------------------NLHVQHLGNNVFL------LQTLFGAVILLANCVA 397

Query: 392 -WIIDRLGRKKTMALCFVIFSFCSLLLFICVGRNVLTLLLFIARAFISGGFQA---AYVY 447
            W +  + R+ +  L   + + C LL  I V + + TL   +A   +     A   A+ +
Sbjct: 398 PWALKYMNRRASQMLLMFLLAIC-LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAH 456

Query: 448 TPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVY---LTLAVYSGCCLLAALA 504
             EV PT  RA  +G  +  A +   + P    +M+  SVY   L   +Y     ++  A
Sbjct: 457 GNEVIPTIIRARAMGINATFANIAGALAP----LMMILSVYSPPLPWIIYGVFPFISGFA 512

Query: 505 SCFLPIETKGRGLQESSHRE 524
              LP ET+ + L ++   E
Sbjct: 513 FLLLP-ETRNKPLFDTIQDE 531


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,263,652
Number of Sequences: 37866
Number of extensions: 797244
Number of successful extensions: 2464
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 2267
Number of HSP's gapped (non-prelim): 129
length of query: 548
length of database: 18,247,518
effective HSP length: 107
effective length of query: 441
effective length of database: 14,195,856
effective search space: 6260372496
effective search space used: 6260372496
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.