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Search of human proteins with 24234683
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
(963 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens] 1994 0.0
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 809 0.0
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens] 803 0.0
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens] 785 0.0
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens] 390 e-108
gi|22550104 ubiquitin specific protease 32 [Homo sapiens] 292 1e-78
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 251 2e-66
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 190 6e-48
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 190 6e-48
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 190 6e-48
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 154 3e-37
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 154 4e-37
gi|148612811 ubiquitin specific protease 43 [Homo sapiens] 143 7e-34
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens] 139 1e-32
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 127 4e-29
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 115 2e-25
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 115 2e-25
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 107 7e-23
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens] 107 7e-23
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens] 107 7e-23
gi|239751420 PREDICTED: similar to hCG2039376 [Homo sapiens] 106 9e-23
gi|183396780 ubiquitin specific protease 20 [Homo sapiens] 105 2e-22
gi|183397136 ubiquitin specific protease 20 [Homo sapiens] 105 2e-22
gi|183397134 ubiquitin specific protease 20 [Homo sapiens] 105 2e-22
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 96 2e-19
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens] 90 1e-17
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 88 4e-17
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] 85 3e-16
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] 85 3e-16
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens] 85 3e-16
>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
Length = 963
Score = 1994 bits (5165), Expect = 0.0
Identities = 963/963 (100%), Positives = 963/963 (100%)
Query: 1 MAVAPRLFGGLCFRFRDQNPEVAVEGRLPISHSCVGCRRERTAMATVAANPAAAAAAVAA 60
MAVAPRLFGGLCFRFRDQNPEVAVEGRLPISHSCVGCRRERTAMATVAANPAAAAAAVAA
Sbjct: 1 MAVAPRLFGGLCFRFRDQNPEVAVEGRLPISHSCVGCRRERTAMATVAANPAAAAAAVAA 60
Query: 61 AAAVTEDREPQHEELPGLDSQWRQIENGESGRERPLRAGESWFLVEKHWYKQWEAYVQGG 120
AAAVTEDREPQHEELPGLDSQWRQIENGESGRERPLRAGESWFLVEKHWYKQWEAYVQGG
Sbjct: 61 AAAVTEDREPQHEELPGLDSQWRQIENGESGRERPLRAGESWFLVEKHWYKQWEAYVQGG 120
Query: 121 DQDSSTFPGCINNATLFQDEINWRLKEGLVEGEDYVLLPAAAWHYLVSWYGLEHGQPPIE 180
DQDSSTFPGCINNATLFQDEINWRLKEGLVEGEDYVLLPAAAWHYLVSWYGLEHGQPPIE
Sbjct: 121 DQDSSTFPGCINNATLFQDEINWRLKEGLVEGEDYVLLPAAAWHYLVSWYGLEHGQPPIE 180
Query: 181 RKVIELPNIQKVEVYPVELLLVRHNDLGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDT 240
RKVIELPNIQKVEVYPVELLLVRHNDLGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDT
Sbjct: 181 RKVIELPNIQKVEVYPVELLLVRHNDLGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDT 240
Query: 241 RLWAKNSEGSLDRLYDTHITVLDAALETGQLIIMETRKKDGTWPSAQLHVMNNNMSEEDE 300
RLWAKNSEGSLDRLYDTHITVLDAALETGQLIIMETRKKDGTWPSAQLHVMNNNMSEEDE
Sbjct: 241 RLWAKNSEGSLDRLYDTHITVLDAALETGQLIIMETRKKDGTWPSAQLHVMNNNMSEEDE 300
Query: 301 DFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAE 360
DFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAE
Sbjct: 301 DFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAE 360
Query: 361 AYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVK 420
AYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVK
Sbjct: 361 AYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVK 420
Query: 421 KKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDP 480
KKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDP
Sbjct: 421 KKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDP 480
Query: 481 FCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPERM 540
FCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPERM
Sbjct: 481 FCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPERM 540
Query: 541 MVADVFSHRFYKLYQLEEPLSSILDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRERTPA 600
MVADVFSHRFYKLYQLEEPLSSILDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRERTPA
Sbjct: 541 MVADVFSHRFYKLYQLEEPLSSILDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRERTPA 600
Query: 601 RDYNNSYYGLMLFGHPLLVSVPRDRFTWEGLYNVLMYRLSRYVTKPNSDDEDDGDEKEDD 660
RDYNNSYYGLMLFGHPLLVSVPRDRFTWEGLYNVLMYRLSRYVTKPNSDDEDDGDEKEDD
Sbjct: 601 RDYNNSYYGLMLFGHPLLVSVPRDRFTWEGLYNVLMYRLSRYVTKPNSDDEDDGDEKEDD 660
Query: 661 EEDKDDVPGPSTGGSLRDPEPEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTLQ 720
EEDKDDVPGPSTGGSLRDPEPEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTLQ
Sbjct: 661 EEDKDDVPGPSTGGSLRDPEPEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTLQ 720
Query: 721 TVNSNGTSDRTTSPEEVHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKKAPVR 780
TVNSNGTSDRTTSPEEVHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKKAPVR
Sbjct: 721 TVNSNGTSDRTTSPEEVHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKKAPVR 780
Query: 781 LQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREK 840
LQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREK
Sbjct: 781 LQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREK 840
Query: 841 LDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQ 900
LDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQ
Sbjct: 841 LDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQ 900
Query: 901 WHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLLSPAGSSGAPASPACSSPPSSEFM 960
WHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLLSPAGSSGAPASPACSSPPSSEFM
Sbjct: 901 WHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLLSPAGSSGAPASPACSSPPSSEFM 960
Query: 961 DVN 963
DVN
Sbjct: 961 DVN 963
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 809 bits (2089), Expect = 0.0
Identities = 425/902 (47%), Positives = 577/902 (63%), Gaps = 86/902 (9%)
Query: 96 LRAGESWFLVEKHWYKQWEAYV--------QGGDQDSSTFPGCINNATLFQDEINWRLKE 147
LR G++W+LV+ W+KQW+ YV Q GDQ+ +PG I+N+ L +D LKE
Sbjct: 24 LRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQN--VYPGPIDNSGLLKDGDAQSLKE 81
Query: 148 GLVEGEDYVLLPAAAWHYLVSWYGLEHGQPPIERKVIELPNIQK---VEVYPVELLLVRH 204
L++ DY+LLP W+ LVSWY L GQ PI RKV+E K VEVY EL L +
Sbjct: 82 HLIDELDYILLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCEN 141
Query: 205 NDLGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDA 264
++ T +FS D+I + + R+ F + +++TRLW K + + L T+ DA
Sbjct: 142 GNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLWNKYMSNTFEPLNKPDSTIQDA 201
Query: 265 ALETGQLIIMETRKKDGTWPSAQL--HVMNNNM------SEEDEDFKG------QPGICG 310
L GQ++++E + +DGTWP +V N+N + ++ D+ QPG+CG
Sbjct: 202 GLYQGQVLVIEQKNEDGTWPRGPSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCG 261
Query: 311 LTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAW 370
L+NLGNTCFMNSA+QCLSN P LTEYFLN+ Y EELNF NPLGM+GEIA++YA+L+KQ W
Sbjct: 262 LSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMW 321
Query: 371 SGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDA 430
SG + P FK +VG FA QF GYQQ D QELL+FLLDGLHEDLNR++KK Y++L DA
Sbjct: 322 SGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDA 381
Query: 431 AGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPI 490
GRPD+ VA+EAW+NH +RNDS+IVD FHGLFKSTLVCP+C +SVTFDPFCYL++PLP+
Sbjct: 382 DGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPM 441
Query: 491 SHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPERMMVADVFSHRF 550
+R LEV+ + MDP KP Q+++VVPK G I DLC ALS +GI ++M+V D+++HRF
Sbjct: 442 KKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRF 501
Query: 551 YKLYQLEEPLSSILDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRERTPARDYNNSYYGL 610
++++ ++E LSSI++RDDI+V+E++ I E + E +++PV LRE+ Y + + G
Sbjct: 502 HRIFAMDENLSSIMERDDIYVFEIN--INRTEDT-EHVIIPVCLREKFRHSSYTH-HTGS 557
Query: 611 MLFGHPLLVSVPRDRFTWEGLYNVLMYRLSRYVTKPNSDDEDDG---------------- 654
LFG P L++VPR+ T + LYN+L+ R+ RYV +E +G
Sbjct: 558 SLFGQPFLMAVPRNN-TEDKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPN 616
Query: 655 -------------DEKEDDEEDKDDVPGPSTGGSLRDPEPEQAGPSSGVTNRCPFLLDNC 701
DE +D+ ++P + D +G+ D C
Sbjct: 617 GIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGGDNDSENGLCTE-----DTC 671
Query: 702 LGTSQWPPRRRRKQLFTLQTVNSNGTSDRTTSPEEVH-----------AQPYIAIDWEPE 750
G +K+LFT Q N T + H + ++A+DW+P+
Sbjct: 672 KGQL----TGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFLALDWDPD 727
Query: 751 MKKRYYDEVEAEGYVKHDCVGYVMKKAP-VRLQECIELFTTVETLEKENPWYCPSCKQHQ 809
+KKRY+DE AE + KH+ V Y K P V+L++CIELFTT E L E+PWYCP+CK+HQ
Sbjct: 728 LKKRYFDENAAEDFEKHESVEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQ 787
Query: 810 LATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVIQPQNESNPEL 869
ATKKLDLW LP +L++HLKRFSY+++ R+KLDTLV+FPI DLD SEF+I P N
Sbjct: 788 QATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLINP----NAGP 843
Query: 870 YKYDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQR 929
+Y+LIAVSNHYGGM GHYT FA NKD G+W+YFDD+SVS +E+QI SKAAYVLFYQR
Sbjct: 844 CRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQR 903
Query: 930 QD 931
QD
Sbjct: 904 QD 905
>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
Length = 916
Score = 803 bits (2075), Expect = 0.0
Identities = 435/903 (48%), Positives = 574/903 (63%), Gaps = 75/903 (8%)
Query: 96 LRAGESWFLVEKHWYKQWEAYVQGGDQDS------STFPGCINNATLFQDEINWRLKEGL 149
L+ G W+L++ W+KQW+ YV D + FPG I+N+ LF D + LKE L
Sbjct: 28 LQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHL 87
Query: 150 VEGEDYVLLPAAAWHYLVSWYGLEHGQPPIERKVIE---LPNIQKVEVYPVELLLVRHND 206
++ DYVL+P AW+ L++WYG GQ PI RKV+E KVEVY +EL L ++D
Sbjct: 88 IDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEHGLFVKHCKVEVYLLELKLCENSD 147
Query: 207 LGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDAAL 266
+ FS D+I + + R+ F + + +TRLW K + ++L TV DA L
Sbjct: 148 PTNVLSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTVQDAGL 207
Query: 267 ETGQLIIMETRKKDGTWPSAQLHVMNNNMS-----EEDEDFKGQPGICGLTNLGNTCFMN 321
GQ++++E + +DGTWP L + S +E QPG+CGL NLGNTCFMN
Sbjct: 208 YQGQVLVIEPQNEDGTWPRQTLQSNGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMN 267
Query: 322 SALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHV 381
SALQCLSN LT+YFL + Y E+N NPLGMKGEIAEAYA+L+KQ WSG + P +
Sbjct: 268 SALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRM 327
Query: 382 FKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQE 441
FK +VG FA QF GYQQ DSQELL+FLLDGLHEDLNRVKKK Y+EL DA GRPD VA+E
Sbjct: 328 FKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKE 387
Query: 442 AWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFI 501
AW+NH+ RNDSVIVDTFHGLFKSTLVCP+C VSVTFDPFCYL++PLP+ RV+EVF +
Sbjct: 388 AWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLV 447
Query: 502 PMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPERMMVADVFSHRFYKLYQLEEPLS 561
P DP +P Q+R+ VP G +SDLC ALS+ +GI+ E M+VADV++HRF+K++Q++E L+
Sbjct: 448 PADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLN 507
Query: 562 SILDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRERTPARDYNNSYYGLMLFGHPLLVSV 621
I+ RDDIFVYEV +++GS E + +PVY RER +S L+G PLL+SV
Sbjct: 508 HIMPRDDIFVYEVCS--TSVDGS-ECVTLPVYFRERKSRPSSTSS--ASALYGQPLLLSV 562
Query: 622 PRDRFTWEGLYNVLMYRLSRYVTKP-------------------NSDDEDDGDEKEDDEE 662
P+ + T E LY + R+SRYV +P NS + +D +E E EE
Sbjct: 563 PKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGEDEEEMEHQEE 622
Query: 663 DKDDVPGPSTGGSLRDP---EPEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTL 719
K+ + T GS D +P + CP K+LFT
Sbjct: 623 GKEQL--SETEGSGEDEPGNDPSETTQKKIKGQPCP------------------KRLFTF 662
Query: 720 QTVNSNGTSDRTTSPEE-----VHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCV--GY 772
VNS GT+D + + ++++ +A+DW+ E ++ YYDE E+E Y KH +
Sbjct: 663 SLVNSYGTADINSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQ 722
Query: 773 VMKKAPVRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFS 832
KK V L++CIELFTT+ETL + +PWYCP+CK+HQ ATKK DLW LP+IL++HLKRFS
Sbjct: 723 KKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFS 782
Query: 833 YTKFSREKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTF 892
Y ++ R+KLDT+VEFPIR L+ SEFV + Y YDLIAVSNHYG M GHYT +
Sbjct: 783 YNRYWRDKLDTVVEFPIRGLNMSEFVC----NLSARPYVYDLIAVSNHYGAMGVGHYTAY 838
Query: 893 ACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQD---VARRLLSPAGSSGAPASP 949
A NK +G+W+YFDD++VS +E+QI +KAAYVLFYQR+D LS +GSS P
Sbjct: 839 AKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRP 898
Query: 950 ACS 952
+ S
Sbjct: 899 SSS 901
>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
Length = 963
Score = 785 bits (2027), Expect = 0.0
Identities = 437/950 (46%), Positives = 577/950 (60%), Gaps = 122/950 (12%)
Query: 96 LRAGESWFLVEKHWYKQWEAYVQGGDQDS------STFPGCINNATLFQDEINWRLKEGL 149
L+ G W+L++ W+KQW+ YV D + FPG I+N+ LF D + LKE L
Sbjct: 28 LQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHL 87
Query: 150 VEGEDYVLLPAAAWHYLVSWYGLEHGQPPIERKVIE---LPNIQKVEVYPVELLLVRHND 206
++ DYVL+P AW+ L++WYG GQ PI RKV+E KVEVY +EL L ++D
Sbjct: 88 IDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEHGLFVKHCKVEVYLLELKLCENSD 147
Query: 207 LGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDAAL 266
+ FS D+I + + R+ F + + +TRLW K + ++L TV DA L
Sbjct: 148 PTNVLSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTVQDAGL 207
Query: 267 ETGQLIIMETRKKDGTWP------------------------------SAQLHVMNNNMS 296
GQ++++E + +DGTWP SA L ++ S
Sbjct: 208 YQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSPKSSASPYSSVSASLIANGDSTS 267
Query: 297 ----------------------EEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLT 334
+E QPG+CGL NLGNTCFMNSALQCLSN LT
Sbjct: 268 TCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLT 327
Query: 335 EYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFL 394
+YFL + Y E+N NPLGMKGEIAEAYA+L+KQ WSG + P +FK +VG FA QF
Sbjct: 328 DYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFS 387
Query: 395 GYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVI 454
GYQQ DSQELL+FLLDGLHEDLNRVKKK Y+EL DA GRPD VA+EAW+NH+ RNDSVI
Sbjct: 388 GYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVI 447
Query: 455 VDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRL 514
VDTFHGLFKSTLVCP+C VSVTFDPFCYL++PLP+ RV+EVF +P DP +P Q+R+
Sbjct: 448 VDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRV 507
Query: 515 VVPKKGKISDLCVALSKHTGISPERMMVADVFSHRFYKLYQLEEPLSSILDRDDIFVYEV 574
VP G +SDLC ALS+ +GI+ E M+VADV++HRF+K++Q++E L+ I+ RDDIFVYEV
Sbjct: 508 TVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEV 567
Query: 575 SGRIEAIEGSREDIVVPVYLRERTPARDYNNSYYGLMLFGHPLLVSVPRDRFTWEGLYNV 634
+++GS E + +PVY RER +S L+G PLL+SVP+ + T E LY
Sbjct: 568 CS--TSVDGS-ECVTLPVYFRERKSRPSSTSS--ASALYGQPLLLSVPKHKLTLESLYQA 622
Query: 635 LMYRLSRYVTKP-------------------NSDDEDDGDEKEDDEEDKDDVPGPSTGGS 675
+ R+SRYV +P NS + +D +E E EE K+ + T GS
Sbjct: 623 VCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGEDEEEMEHQEEGKEQL--SETEGS 680
Query: 676 LRDP---EPEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTLQTVNSNGTSDRTT 732
D +P + CP K+LFT VNS GT+D +
Sbjct: 681 GEDEPGNDPSETTQKKIKGQPCP------------------KRLFTFSLVNSYGTADINS 722
Query: 733 SPEE-----VHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCV--GYVMKKAPVRLQECI 785
+ ++++ +A+DW+ E ++ YYDE E+E Y KH + KK V L++CI
Sbjct: 723 LAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCI 782
Query: 786 ELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLV 845
ELFTT+ETL + +PWYCP+CK+HQ ATKK DLW LP+IL++HLKRFSY ++ R+KLDT+V
Sbjct: 783 ELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVV 842
Query: 846 EFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFD 905
EFPIR L+ SEFV + Y YDLIAVSNHYG M GHYT +A NK +G+W+YFD
Sbjct: 843 EFPIRGLNMSEFVC----NLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFD 898
Query: 906 DNSVSPVNENQIESKAAYVLFYQRQD---VARRLLSPAGSSGAPASPACS 952
D++VS +E+QI +KAAYVLFYQR+D LS +GSS P+ S
Sbjct: 899 DSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSS 948
>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
Length = 1318
Score = 390 bits (1003), Expect = e-108
Identities = 267/783 (34%), Positives = 383/783 (48%), Gaps = 117/783 (14%)
Query: 284 PSAQLHVMNNNMSEEDEDFKGQ--PGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNC 341
P V +++ EE+E+ K PG GL NLGNTCFMNS +Q LSN +L ++F +
Sbjct: 470 PMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRS 529
Query: 342 YLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDS 401
+ E+N+ NPLG G +A +A L++ W G H + P K V ASQF GY QHD+
Sbjct: 530 FEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDA 589
Query: 402 QELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGL 461
QE ++FLLDGLHEDLNR++ K Y E D+ GRPD+ VA+EAWQ HK RNDS IVD F G
Sbjct: 590 QEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQ 649
Query: 462 FKSTLVCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGK 521
+KS LVCP C VS+TFDPF YL VPLP ++VL VF+ +P KP + + V K+
Sbjct: 650 YKSKLVCPVCAKVSITFDPFLYLPVPLP-QKQKVLPVFYFAREPHSKPIKFLVSVSKENS 708
Query: 522 -ISDLCVALSKHTGISPERMMVADVFSHRFYKLYQLEEPLSSILDRDDIFVYEVSGRIEA 580
S++ +LS+ + PE + +A+V +RF++++ L ++ D + +E+ + +
Sbjct: 709 TASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFEL---LSS 765
Query: 581 IEGSREDIVVPVYLRERTPA------------------------RDYNNSYYGLML---- 612
+V+ V R + P+ R Y Y +
Sbjct: 766 ELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTH 825
Query: 613 ------------FGHPLLVSVPRDRFTWEGLYNVL----MYRLSRY-------------- 642
G+P LVSVP R T+ L +L Y +S +
Sbjct: 826 WPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQ 885
Query: 643 ----VTKPNSDDEDDGDEKEDDEEDKD-DVPGPSTGGSL----------RDPEPEQAGPS 687
T ++ + GD + D + + + P G R P P +G S
Sbjct: 886 SPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGIS 945
Query: 688 SGVTNRCPFLL------------DNCLGTSQWPP---RRRRKQLFTLQTVNSN---GTSD 729
S + P + + + Q P Q F + +SN D
Sbjct: 946 SEMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLED 1005
Query: 730 RTTSPEEVHAQPYIAIDWEPEMKKRYYDEV---EAEGYVKHDCVGYVMKKAPVRLQECIE 786
+ +P E+ +A+ W + + + V E E G + L +C+
Sbjct: 1006 KGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLN 1065
Query: 787 LFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFS-REKLDTLV 845
LFT E L E WYCP CKQH+ A+K+L LW LP +LI+ LKRFS+ F R+K++ LV
Sbjct: 1066 LFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLV 1125
Query: 846 EFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFA--CNKDSGQ--- 900
EFP+R+LD S+F I + E P YDL AV NHYGGM GHYT A N S Q
Sbjct: 1126 EFPVRNLDLSKFCIGQKEEQLP---SYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSD 1182
Query: 901 --WHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLLSPAGSSG-----APASPACSS 953
W FDD++V+ V+E+Q+ ++ AYVLFY+R++ AG S PA+ A +S
Sbjct: 1183 VGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAAS 1242
Query: 954 PPS 956
S
Sbjct: 1243 QAS 1245
>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
Length = 1604
Score = 292 bits (747), Expect = 1e-78
Identities = 172/455 (37%), Positives = 252/455 (55%), Gaps = 43/455 (9%)
Query: 128 PGCINNATLFQDEI---------NWRLKEG--LVEGEDYVLLPAAAWHYLVSWYG--LEH 174
PG I+N L E RLK L+ G DY ++P W L WYG L
Sbjct: 521 PGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLAL 580
Query: 175 GQPPIERKVIELPNIQKVEVYPVELLLVRHNDLGKS------------------------ 210
+P I+ ++P + E++P LL +R ++
Sbjct: 581 PRPVIKNSKTDIPEL---ELFPRYLLFLRQQPATRTQQSNIWVNMGNVPSPNAPLKRVLA 637
Query: 211 HTVQFSHTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDAALETGQ 270
+T FS +I + +R ++ +ED RLW NSE L L D + ++ Q
Sbjct: 638 YTGCFSRMQTIKEIHEYLSQRLRIK-EEDMRLWLYNSENYLTLLDDEDHKLEYLKIQDEQ 696
Query: 271 LIIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNV 330
+++E R KD +WP + N++ + + + G GL+NLGNTCFMNS++QC+SN
Sbjct: 697 HLVIEVRNKDMSWPEEMSFIANSSKIDRHK-VPTEKGATGLSNLGNTCFMNSSIQCVSNT 755
Query: 331 PQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFA 390
LT+YF++ +L ELN NP+GMKG +A+ Y DLV++ WSG +++ P + + +A
Sbjct: 756 QPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYA 815
Query: 391 SQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRN 450
+F G+QQ DSQELL+FLLDGLHEDLNRV +K YVEL D+ GRPD EVA EAW NH RRN
Sbjct: 816 PRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRN 875
Query: 451 DSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPE 510
S++VD FHG +S + C CG++SV FDPF +LS+PLP+ LE+ I +D P
Sbjct: 876 RSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLD-GTTPV 934
Query: 511 QHRLVVPKKGKISDLCVALSKHTGISPERMMVADV 545
++ L + K + L LS G++ E++++A+V
Sbjct: 935 RYGLRLNMDEKYTGLKKQLSDLCGLNSEQILLAEV 969
Score = 93.2 bits (230), Expect = 1e-18
Identities = 48/120 (40%), Positives = 64/120 (53%), Gaps = 2/120 (1%)
Query: 742 YIAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKKA--PVRLQECIELFTTVETLEKENP 799
YIA+DW+P Y + +H+ V + P+ L C+ FT+ E L +
Sbjct: 1194 YIAVDWDPTALHLRYQTSQERVVDEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEM 1253
Query: 800 WYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVI 859
+YC CK H LATKKLDLW LP ILIIHLKRF + K +V+FP D S F++
Sbjct: 1254 YYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAFLV 1313
Score = 53.1 bits (126), Expect = 1e-06
Identities = 22/61 (36%), Positives = 43/61 (70%), Gaps = 1/61 (1%)
Query: 872 YDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQD 931
Y+L A+S H G + GHY T+A N + +W+ ++D+S ++ ++I++ +AY+LFY++Q
Sbjct: 1510 YNLYAISCHSGILGGGHYVTYAKNPNC-KWYCYNDSSCKELHPDEIDTDSAYILFYEQQG 1568
Query: 932 V 932
+
Sbjct: 1569 I 1569
Score = 35.4 bits (80), Expect = 0.26
Identities = 16/45 (35%), Positives = 25/45 (55%), Gaps = 2/45 (4%)
Query: 76 PGLDSQWRQIENGESGRERP--LRAGESWFLVEKHWYKQWEAYVQ 118
P + QI G RE L+AG +WF++ W++QW+ YV+
Sbjct: 368 PATPEEEGQIIRGWLERESRYGLQAGHNWFIISMQWWQQWKEYVK 412
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 251 bits (642), Expect = 2e-66
Identities = 127/271 (46%), Positives = 177/271 (65%), Gaps = 2/271 (0%)
Query: 275 ETRKKDGTWPSAQLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLT 334
E KD +WP N++ + + + G GL+NLGNTCFMNS++QC+SN LT
Sbjct: 499 EVHNKDMSWPEEMSFTANSSKIDRQK-VPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLT 557
Query: 335 EYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFL 394
+YF++ +L ELN NP+GMKG +A+ Y DLV++ WSG +S+ P + + +A +F
Sbjct: 558 QYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFD 617
Query: 395 GYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVI 454
G+QQ DSQELL+FLLDGLHEDLNRV +K YVEL D+ GRPD EVA EAW NH RRN S+I
Sbjct: 618 GFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSII 677
Query: 455 VDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRL 514
VD FHG +S + C CG++SV FDPF +LS+PLP+ LE+ I +D P ++ L
Sbjct: 678 VDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLEITVIKLD-GTTPVRYGL 736
Query: 515 VVPKKGKISDLCVALSKHTGISPERMMVADV 545
+ K + L L G++ E++++A+V
Sbjct: 737 RLNMDEKYTGLKKQLRDLCGLNSEQILLAEV 767
Score = 89.4 bits (220), Expect = 2e-17
Identities = 59/177 (33%), Positives = 76/177 (42%), Gaps = 25/177 (14%)
Query: 699 DNCLGTSQWPPRRRRKQLFTLQTVNSNGTSDRTT--------------SPEEVHAQPYIA 744
DNC+G Q+P FTL+ V +G S YIA
Sbjct: 944 DNCMGY-QYP--------FTLRVVQKDGNSCAWCPQYRFCRGCKIDCGEDRAFIGNAYIA 994
Query: 745 IDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKKA--PVRLQECIELFTTVETLEKENPWYC 802
+DW P Y + KH+ V + P+ L C+ FT+ E L + +YC
Sbjct: 995 VDWHPTALHLRYQTSQERVVDKHESVEQSRRAQAEPINLDSCLRAFTSEEELGESEMYYC 1054
Query: 803 PSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVI 859
CK H LATKKLDLW LP LIIHLKRF + K +V F D S F++
Sbjct: 1055 SKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQWIKSQKIVRFLRESFDPSAFLV 1111
Score = 53.1 bits (126), Expect = 1e-06
Identities = 22/61 (36%), Positives = 43/61 (70%), Gaps = 1/61 (1%)
Query: 872 YDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQD 931
Y+L A+S H G + GHY T+A N + +W+ ++D+S ++ ++I++ +AY+LFY++Q
Sbjct: 1312 YNLYAISCHSGILSGGHYITYAKNPNC-KWYCYNDSSCEELHPDEIDTDSAYILFYEQQG 1370
Query: 932 V 932
+
Sbjct: 1371 I 1371
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 190 bits (482), Expect = 6e-48
Identities = 93/192 (48%), Positives = 122/192 (63%)
Query: 306 PGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADL 365
P + GL NLGNTC+MNS LQCL N P L +YF NCY +++N N LG KGE+AE + +
Sbjct: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGII 833
Query: 366 VKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYV 425
+K W+G +R I P FK +G QF GY Q DSQELL FL+DGLHEDLN+ ++
Sbjct: 834 MKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRY 893
Query: 426 ELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLS 485
+ + D + A+ AWQ HK+ N+S+IV F G FKST+ C C S TF+ F YLS
Sbjct: 894 KEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLS 953
Query: 486 VPLPISHKRVLE 497
+PL + K L+
Sbjct: 954 LPLASTSKCTLQ 965
Score = 146 bits (369), Expect = 8e-35
Identities = 66/147 (44%), Positives = 99/147 (67%), Gaps = 4/147 (2%)
Query: 781 LQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREK 840
LQ+C+ LF+ E L N +YC C+ + + KK+++W LP +L++HLKRFSY ++K
Sbjct: 964 LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023
Query: 841 LDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQ 900
L T V+FP+ +LD S++VI P+N L KY+L +VSNHYGG+ GHYT + N +
Sbjct: 1024 LQTSVDFPLENLDLSQYVIGPKN----NLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQR 1079
Query: 901 WHYFDDNSVSPVNENQIESKAAYVLFY 927
W FDD+ VS ++ + ++S AAY+LFY
Sbjct: 1080 WFKFDDHEVSDISVSSVKSSAAYILFY 1106
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 190 bits (482), Expect = 6e-48
Identities = 93/192 (48%), Positives = 122/192 (63%)
Query: 306 PGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADL 365
P + GL NLGNTC+MNS LQCL N P L +YF NCY +++N N LG KGE+AE + +
Sbjct: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGII 833
Query: 366 VKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYV 425
+K W+G +R I P FK +G QF GY Q DSQELL FL+DGLHEDLN+ ++
Sbjct: 834 MKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRY 893
Query: 426 ELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLS 485
+ + D + A+ AWQ HK+ N+S+IV F G FKST+ C C S TF+ F YLS
Sbjct: 894 KEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLS 953
Query: 486 VPLPISHKRVLE 497
+PL + K L+
Sbjct: 954 LPLASTSKCTLQ 965
Score = 146 bits (369), Expect = 8e-35
Identities = 66/147 (44%), Positives = 99/147 (67%), Gaps = 4/147 (2%)
Query: 781 LQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREK 840
LQ+C+ LF+ E L N +YC C+ + + KK+++W LP +L++HLKRFSY ++K
Sbjct: 964 LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023
Query: 841 LDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQ 900
L T V+FP+ +LD S++VI P+N L KY+L +VSNHYGG+ GHYT + N +
Sbjct: 1024 LQTSVDFPLENLDLSQYVIGPKN----NLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQR 1079
Query: 901 WHYFDDNSVSPVNENQIESKAAYVLFY 927
W FDD+ VS ++ + ++S AAY+LFY
Sbjct: 1080 WFKFDDHEVSDISVSSVKSSAAYILFY 1106
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 190 bits (482), Expect = 6e-48
Identities = 93/192 (48%), Positives = 122/192 (63%)
Query: 306 PGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADL 365
P + GL NLGNTC+MNS LQCL N P L +YF NCY +++N N LG KGE+AE + +
Sbjct: 774 PALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGII 833
Query: 366 VKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYV 425
+K W+G +R I P FK +G QF GY Q DSQELL FL+DGLHEDLN+ ++
Sbjct: 834 MKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRY 893
Query: 426 ELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLS 485
+ + D + A+ AWQ HK+ N+S+IV F G FKST+ C C S TF+ F YLS
Sbjct: 894 KEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLS 953
Query: 486 VPLPISHKRVLE 497
+PL + K L+
Sbjct: 954 LPLASTSKCTLQ 965
Score = 146 bits (369), Expect = 8e-35
Identities = 66/147 (44%), Positives = 99/147 (67%), Gaps = 4/147 (2%)
Query: 781 LQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREK 840
LQ+C+ LF+ E L N +YC C+ + + KK+++W LP +L++HLKRFSY ++K
Sbjct: 964 LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023
Query: 841 LDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQ 900
L T V+FP+ +LD S++VI P+N L KY+L +VSNHYGG+ GHYT + N +
Sbjct: 1024 LQTSVDFPLENLDLSQYVIGPKN----NLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQR 1079
Query: 901 WHYFDDNSVSPVNENQIESKAAYVLFY 927
W FDD+ VS ++ + ++S AAY+LFY
Sbjct: 1080 WFKFDDHEVSDISVSSVKSSAAYILFY 1106
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 154 bits (390), Expect = 3e-37
Identities = 83/215 (38%), Positives = 118/215 (54%), Gaps = 3/215 (1%)
Query: 275 ETRKKDGTWPSAQLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLT 334
E R + PS L + + ++ K G+ GL NLGNTCFMNS LQCLSN +L
Sbjct: 24 ELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELR 83
Query: 335 EYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIV-PHVFKNKVGHFASQF 393
+Y L Y+ +L+ + + E +A L++ W+ +V P FK ++ +A +F
Sbjct: 84 DYCLQRLYMRDLHHGS--NAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRF 141
Query: 394 LGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSV 453
+GY Q D+QE L FLLDGLH ++NRV + + PD E ++ W+ + R DS
Sbjct: 142 VGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSR 201
Query: 454 IVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPL 488
I D F G KS+L C DCG S FDPF LS+P+
Sbjct: 202 IGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI 236
Score = 124 bits (312), Expect = 3e-28
Identities = 59/150 (39%), Positives = 90/150 (60%), Gaps = 5/150 (3%)
Query: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838
V L +C+ LFT + L+ + C C+ + KK + P+IL++HLKRFS ++
Sbjct: 244 VTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRT 303
Query: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898
KL T V FP+RDLD EF + N + Y+L AVSNH G GHYT + + +
Sbjct: 304 SKLTTFVNFPLRDLDLREFASENTNHA-----VYNLYAVSNHSGTTMGGHYTAYCRSPGT 358
Query: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQ 928
G+WH F+D+SV+P++ +Q+ + AY+LFY+
Sbjct: 359 GEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 388
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 154 bits (389), Expect = 4e-37
Identities = 85/221 (38%), Positives = 119/221 (53%), Gaps = 8/221 (3%)
Query: 269 GQLIIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLS 328
G+ + ET K PS + M+ K G+ GL NLGNTCFMNS LQCLS
Sbjct: 232 GRYTLWETGKGQAPGPSRSSSPGRDGMNS-----KSAQGLAGLRNLGNTCFMNSILQCLS 286
Query: 329 NVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIV-PHVFKNKVG 387
N +L +Y L Y+ +L+ + + E +A L++ W+ +V P FK ++
Sbjct: 287 NTRELRDYCLQRLYMRDLHHGS--NAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQ 344
Query: 388 HFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHK 447
+A +F+GY Q D+QE L FLLDGLH ++NRV + + PD E ++ W+ +
Sbjct: 345 RYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYL 404
Query: 448 RRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPL 488
R DS I D F G KS+L C DCG S FDPF LS+P+
Sbjct: 405 EREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI 445
Score = 124 bits (312), Expect = 3e-28
Identities = 59/150 (39%), Positives = 90/150 (60%), Gaps = 5/150 (3%)
Query: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838
V L +C+ LFT + L+ + C C+ + KK + P+IL++HLKRFS ++
Sbjct: 453 VTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRT 512
Query: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898
KL T V FP+RDLD EF + N + Y+L AVSNH G GHYT + + +
Sbjct: 513 SKLTTFVNFPLRDLDLREFASENTNHA-----VYNLYAVSNHSGTTMGGHYTAYCRSPGT 567
Query: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQ 928
G+WH F+D+SV+P++ +Q+ + AY+LFY+
Sbjct: 568 GEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 597
>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
Length = 1123
Score = 143 bits (361), Expect = 7e-34
Identities = 73/211 (34%), Positives = 114/211 (54%), Gaps = 22/211 (10%)
Query: 743 IAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMK---KAPVRLQECIELFTTVETLEKENP 799
+A++W+ +K+R + ++ E D V + + L EC + +T E L +++
Sbjct: 501 LAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDA 560
Query: 800 WYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVI 859
W CP C+ Q KL LW LP+ILIIHLKRF R KL TLV+FP+ L+ + V
Sbjct: 561 WKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVA 620
Query: 860 QPQNE-------------------SNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQ 900
Q S P + YDL AV NH+G ++ GHYT + N GQ
Sbjct: 621 QRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQ 680
Query: 901 WHYFDDNSVSPVNENQIESKAAYVLFYQRQD 931
W+ +DD++V P+ E+++ ++ AY+LFYQ+++
Sbjct: 681 WYSYDDSTVEPLREDEVNTRGAYILFYQKRN 711
Score = 130 bits (326), Expect = 8e-30
Identities = 83/270 (30%), Positives = 135/270 (50%), Gaps = 10/270 (3%)
Query: 306 PGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADL 365
PG GL N GNTCFMN+ +QCLSN L E+ Y R G + E+ E A L
Sbjct: 98 PGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRY------RAAPG-RAEVTEQLAAL 150
Query: 366 VKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYV 425
V+ W+ + + FKN V + SQF G QHD+ E L +LLD +HEDL +
Sbjct: 151 VRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVS 210
Query: 426 E-LCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYL 484
E L A + + + Q S + F ++S+L CP C S TFDPF +
Sbjct: 211 EKLPPEATKTSENCLSPSAQ--LPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCV 268
Query: 485 SVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPERMMVAD 544
S+P+P+ R L V + ++ + L VP ++ L +++ G+ + +++ +
Sbjct: 269 SLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVILVE 328
Query: 545 VFSHRFYKLYQLEEPLSSILDRDDIFVYEV 574
++ F + + EE L++I + D+++ ++V
Sbjct: 329 LYPSGFQRSFFDEEDLNTIAEGDNVYAFQV 358
>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
Length = 1352
Score = 139 bits (351), Expect = 1e-32
Identities = 75/231 (32%), Positives = 118/231 (51%), Gaps = 22/231 (9%)
Query: 743 IAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKK----APVRLQECIELFTTVETLEKEN 798
+ ++W+ E + + E E + V ++ L +C +L+T E L ++
Sbjct: 556 LVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDD 615
Query: 799 PWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFV 858
W CP CKQ Q + L LW LP++LIIHLKRF R KL +V+FP+ LD + V
Sbjct: 616 AWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHV 675
Query: 859 IQPQNES------------------NPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQ 900
++ S +PE Y YDL AV NH+G M+ GHYT + N G
Sbjct: 676 VKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGL 735
Query: 901 WHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLLSPAGSSGAPASPAC 951
W+ FDD+ V ++E+++ ++ AY+LFYQR+ + + +G+ +S C
Sbjct: 736 WYCFDDSDVQQLSEDEVCTQTAYILFYQRRTAIPSWSANSSVAGSTSSSLC 786
Score = 134 bits (336), Expect = 5e-31
Identities = 88/282 (31%), Positives = 138/282 (48%), Gaps = 23/282 (8%)
Query: 306 PGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYL----------EELNFRNPLGMK 355
PG+ GL N GNTCFMN+ LQCLSN EY Y E+ R G +
Sbjct: 125 PGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQG-Q 183
Query: 356 GEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHED 415
GE+ E A LV+ W+ + FK V A Q+ G QHD+QE L +LLD +HED
Sbjct: 184 GEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHED 243
Query: 416 LNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRN----DSVIVDTFHGLFKSTLVCPDC 471
LN K+ +G+P + E + + + + + F ++S+L CP C
Sbjct: 244 LNHSVKQ--------SGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHC 295
Query: 472 GNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSK 531
S TFDPF +S+P+P+ H R L V + + + VP G ++ L A+S
Sbjct: 296 QKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSM 355
Query: 532 HTGISPERMMVADVFSHRFYKLYQLEEPLSSILDRDDIFVYE 573
T I +++++ +++ F++ + + L ++ + D IF +E
Sbjct: 356 ETKIPTDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFE 397
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 127 bits (320), Expect = 4e-29
Identities = 62/148 (41%), Positives = 98/148 (66%), Gaps = 4/148 (2%)
Query: 781 LQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREK 840
L++C+ FT +E L++ + C CK+ Q +TKK + LP++L +HLKRF +T + R K
Sbjct: 364 LRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNK 423
Query: 841 LDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYG-GMRDGHYTTFACNKDSG 899
+DT VEFP+R LD ++++P+N S PE YDL AV H+G G+ GHYT +A ++ G
Sbjct: 424 VDTYVEFPLRGLDMKCYLLEPEN-SGPESCLYDLAAVVVHHGSGVGSGHYTAYATHE--G 480
Query: 900 QWHYFDDNSVSPVNENQIESKAAYVLFY 927
+W +F+D++V+ +E + AY+LFY
Sbjct: 481 RWFHFNDSTVTLTDEETVVKAKAYILFY 508
Score = 76.6 bits (187), Expect = 1e-13
Identities = 57/194 (29%), Positives = 82/194 (42%), Gaps = 22/194 (11%)
Query: 310 GLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELN----------FRNPLGMKGEIA 359
GL NLGNTCFMN+ LQ LSN+ Q YF +E N R+ +
Sbjct: 160 GLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLV 219
Query: 360 EAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDL--- 416
E + + W G + P V F GYQQ D+ E + +LLD LH +L
Sbjct: 220 EEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGG 279
Query: 417 -NRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVS 475
N V + ++ ++ A +V+ F G+ ++ + C CG S
Sbjct: 280 FNGVSRSAILQENSTLSASNKCCINGA--------STVVTAIFGGILQNEVNCLICGTES 331
Query: 476 VTFDPFCYLSVPLP 489
FDPF LS+ +P
Sbjct: 332 RKFDPFLDLSLDIP 345
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 115 bits (288), Expect = 2e-25
Identities = 64/159 (40%), Positives = 86/159 (54%), Gaps = 7/159 (4%)
Query: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838
V L++C LFT E LE EN C C+Q +TKKL + P IL++HL RFS ++ S
Sbjct: 414 VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473
Query: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898
+K V+FP++ L +F Y L A+ NH G + GHYT C +
Sbjct: 474 KKSSVGVDFPLQRLSLGDFASDKAGSP-----VYQLYALCNHSGSVHYGHYTAL-CRCQT 527
Query: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLL 937
G WH ++D+ VSPV+ENQ+ S YVLFYQ R L
Sbjct: 528 G-WHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL 565
Score = 110 bits (276), Expect = 5e-24
Identities = 68/199 (34%), Positives = 98/199 (49%), Gaps = 19/199 (9%)
Query: 307 GICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLV 366
G GL NLGNTCF+N+ LQCLS+ L ++ L + +E+ G E+ EA+AD++
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
Query: 367 KQAWSGHH-RSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYV 425
W ++ P F+ + F GY Q D+QE L L++ LH ++NR ++
Sbjct: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
Query: 426 ---------------ELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPD 470
L + D + A W+ + R DS IVD F G KS L C
Sbjct: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
Query: 471 CGNVSVTFDPFCYLSVPLP 489
CG S TF+ FC LS+P+P
Sbjct: 387 CGYRSTTFEVFCDLSLPIP 405
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 115 bits (288), Expect = 2e-25
Identities = 64/159 (40%), Positives = 86/159 (54%), Gaps = 7/159 (4%)
Query: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838
V L++C LFT E LE EN C C+Q +TKKL + P IL++HL RFS ++ S
Sbjct: 414 VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473
Query: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898
+K V+FP++ L +F Y L A+ NH G + GHYT C +
Sbjct: 474 KKSSVGVDFPLQRLSLGDFASDKAGSP-----VYQLYALCNHSGSVHYGHYTAL-CRCQT 527
Query: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLL 937
G WH ++D+ VSPV+ENQ+ S YVLFYQ R L
Sbjct: 528 G-WHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL 565
Score = 110 bits (276), Expect = 5e-24
Identities = 68/199 (34%), Positives = 98/199 (49%), Gaps = 19/199 (9%)
Query: 307 GICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLV 366
G GL NLGNTCF+N+ LQCLS+ L ++ L + +E+ G E+ EA+AD++
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
Query: 367 KQAWSGHH-RSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYV 425
W ++ P F+ + F GY Q D+QE L L++ LH ++NR ++
Sbjct: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
Query: 426 ---------------ELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPD 470
L + D + A W+ + R DS IVD F G KS L C
Sbjct: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
Query: 471 CGNVSVTFDPFCYLSVPLP 489
CG S TF+ FC LS+P+P
Sbjct: 387 CGYRSTTFEVFCDLSLPIP 405
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 107 bits (266), Expect = 7e-23
Identities = 54/151 (35%), Positives = 85/151 (56%), Gaps = 3/151 (1%)
Query: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838
V LQ+C+ F + L+ +N + C CK+ + K + PEIL IHLKRF +
Sbjct: 559 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 618
Query: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898
K+ T V FP+ LD F+ + +S ++ YDL++V H+G GHY + N +
Sbjct: 619 TKISTHVSFPLEGLDLQPFLAK---DSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLN 675
Query: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQR 929
W+ FDD SV+ V+E+ +++ AYVLFY++
Sbjct: 676 NLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 706
Score = 80.1 bits (196), Expect = 9e-15
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 14/159 (8%)
Query: 294 NMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLG 353
++ ++ED G+ GL N+GNTC+MN+ALQ LSN P LT++FL+ L +
Sbjct: 170 DIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTD------ 223
Query: 354 MKGEIAEAYADLVKQAW-SGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGL 412
K I ++Y L+ + W S+VP + F GY Q D+QE L L+D L
Sbjct: 224 KKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLL 283
Query: 413 HEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRND 451
HE+L ++ + P +E + K ++D
Sbjct: 284 HEELKE-------QVMEVEEDPQTITTEETMEEDKSQSD 315
Score = 39.3 bits (90), Expect = 0.018
Identities = 23/59 (38%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 434 PDQEVAQEAWQNHKRRND---SVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLP 489
P + AQ A K+++ SVI D F G S++ C C VSVT + F LS+P+P
Sbjct: 452 PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIP 510
>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
Length = 942
Score = 107 bits (266), Expect = 7e-23
Identities = 54/151 (35%), Positives = 85/151 (56%), Gaps = 3/151 (1%)
Query: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838
V LQ+C+ F + L+ +N + C CK+ + K + PEIL IHLKRF +
Sbjct: 567 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 626
Query: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898
K+ T V FP+ LD F+ + +S ++ YDL++V H+G GHY + N +
Sbjct: 627 TKISTHVSFPLEGLDLQPFLAK---DSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLN 683
Query: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQR 929
W+ FDD SV+ V+E+ +++ AYVLFY++
Sbjct: 684 NLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 714
Score = 80.1 bits (196), Expect = 9e-15
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 14/159 (8%)
Query: 294 NMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLG 353
++ ++ED G+ GL N+GNTC+MN+ALQ LSN P LT++FL+ L +
Sbjct: 170 DIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTD------ 223
Query: 354 MKGEIAEAYADLVKQAW-SGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGL 412
K I ++Y L+ + W S+VP + F GY Q D+QE L L+D L
Sbjct: 224 KKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLL 283
Query: 413 HEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRND 451
HE+L ++ + P +E + K ++D
Sbjct: 284 HEELKE-------QVMEVEEDPQTITTEETMEEDKSQSD 315
Score = 39.3 bits (90), Expect = 0.018
Identities = 23/59 (38%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 434 PDQEVAQEAWQNHKRRND---SVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLP 489
P + AQ A K+++ SVI D F G S++ C C VSVT + F LS+P+P
Sbjct: 452 PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIP 510
Score = 38.5 bits (88), Expect = 0.031
Identities = 20/72 (27%), Positives = 39/72 (54%), Gaps = 8/72 (11%)
Query: 101 SWFLVEKHWYKQWEAYVQGGDQDSSTFPGCINNATLFQDEI-NWRLKEGLVEGEDYVLLP 159
+++ + W+++WE++V+G D D PG I+N + + N L++G G+ +
Sbjct: 846 TFYCISMQWFREWESFVKGKDGDP---PGPIDNTKIAVTKCGNVMLRQGADSGQ----IS 898
Query: 160 AAAWHYLVSWYG 171
W++L S YG
Sbjct: 899 EETWNFLQSIYG 910
>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
Length = 911
Score = 107 bits (266), Expect = 7e-23
Identities = 54/151 (35%), Positives = 85/151 (56%), Gaps = 3/151 (1%)
Query: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838
V LQ+C+ F + L+ +N + C CK+ + K + PEIL IHLKRF +
Sbjct: 536 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 595
Query: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898
K+ T V FP+ LD F+ + +S ++ YDL++V H+G GHY + N +
Sbjct: 596 TKISTHVSFPLEGLDLQPFLAK---DSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLN 652
Query: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQR 929
W+ FDD SV+ V+E+ +++ AYVLFY++
Sbjct: 653 NLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 683
Score = 80.1 bits (196), Expect = 9e-15
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 14/159 (8%)
Query: 294 NMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLG 353
++ ++ED G+ GL N+GNTC+MN+ALQ LSN P LT++FL+ L +
Sbjct: 139 DIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTD------ 192
Query: 354 MKGEIAEAYADLVKQAW-SGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGL 412
K I ++Y L+ + W S+VP + F GY Q D+QE L L+D L
Sbjct: 193 KKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLL 252
Query: 413 HEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRND 451
HE+L ++ + P +E + K ++D
Sbjct: 253 HEELKE-------QVMEVEEDPQTITTEETMEEDKSQSD 284
Score = 39.3 bits (90), Expect = 0.018
Identities = 23/59 (38%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 434 PDQEVAQEAWQNHKRRND---SVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLP 489
P + AQ A K+++ SVI D F G S++ C C VSVT + F LS+P+P
Sbjct: 421 PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIP 479
Score = 38.5 bits (88), Expect = 0.031
Identities = 20/72 (27%), Positives = 39/72 (54%), Gaps = 8/72 (11%)
Query: 101 SWFLVEKHWYKQWEAYVQGGDQDSSTFPGCINNATLFQDEI-NWRLKEGLVEGEDYVLLP 159
+++ + W+++WE++V+G D D PG I+N + + N L++G G+ +
Sbjct: 815 TFYCISMQWFREWESFVKGKDGDP---PGPIDNTKIAVTKCGNVMLRQGADSGQ----IS 867
Query: 160 AAAWHYLVSWYG 171
W++L S YG
Sbjct: 868 EETWNFLQSIYG 879
>gi|239751420 PREDICTED: similar to hCG2039376 [Homo sapiens]
Length = 858
Score = 106 bits (265), Expect = 9e-23
Identities = 78/269 (28%), Positives = 124/269 (46%), Gaps = 25/269 (9%)
Query: 128 PGCINNATLFQDEI---------NWRLKEG--LVEGEDYVLLPAAAWHYLVSWYGLEHGQ 176
PG I+N L E RLK L+ G DY ++P W L WYG
Sbjct: 589 PGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLAL 648
Query: 177 P-PIERKVIELPNIQKVEVYPVELLLVRHNDLGKSHTVQFSHTDSIGLVLR-----TARE 230
P P+ ++ ++ P + + + G+S +F S+ +++ A+
Sbjct: 649 PRPVS--IVNSALYKEQNTLPPVIPALWKAEAGRSRGQEFE--TSLANIVKPQSCCVAQA 704
Query: 231 RFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDAALETGQLIIMETRKKDGTWPSAQLHV 290
+ A S G + T + VL L+I+ +KK + +
Sbjct: 705 GLELLVSSSPSALASQSAGITGMSHCTWLVVLFLFDFYCSLLIL--KKKSSV--AEDIGY 760
Query: 291 MNNNMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRN 350
N+ + + G GL+NLGNTCFMNS++QC+SN LT+YF++ +L ELN N
Sbjct: 761 ETNSSKIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTN 820
Query: 351 PLGMKGEIAEAYADLVKQAWSGHHRSIVP 379
P+GMKG +A+ Y DLV++ WSG +++ P
Sbjct: 821 PIGMKGHMAKCYGDLVQELWSGTQKNVAP 849
Score = 35.4 bits (80), Expect = 0.26
Identities = 16/45 (35%), Positives = 25/45 (55%), Gaps = 2/45 (4%)
Query: 76 PGLDSQWRQIENGESGRERP--LRAGESWFLVEKHWYKQWEAYVQ 118
P + QI G RE L+AG +WF++ W++QW+ YV+
Sbjct: 436 PATPEEEGQIIRGWLERESRYGLQAGHNWFIISMQWWQQWKEYVK 480
>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 105 bits (263), Expect = 2e-22
Identities = 53/151 (35%), Positives = 85/151 (56%), Gaps = 3/151 (1%)
Query: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838
V L++C+ F + L+ +N + C CK+ + K + LPEIL IHLKRF +
Sbjct: 537 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596
Query: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898
K+++ V FP+ LD F+ + E ++ YDL++V H+G GHY + N +
Sbjct: 597 FKINSHVSFPLEGLDLRPFLAK---ECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVIN 653
Query: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQR 929
GQW+ FDD V+ V+E +++ YVLFY++
Sbjct: 654 GQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684
Score = 80.1 bits (196), Expect = 9e-15
Identities = 47/120 (39%), Positives = 67/120 (55%), Gaps = 8/120 (6%)
Query: 298 EDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGE 357
ED+D K + G+ G+ NLGN+C+MN+ALQ LSN P LT++FL L + K
Sbjct: 135 EDDDLKPR-GLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTD------KKPA 187
Query: 358 IAEAYADLVKQAWSGHHRS-IVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDL 416
+ ++Y LV + W S +VP + + F GY Q D+QE L L+D LHE+L
Sbjct: 188 LCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
Score = 44.3 bits (103), Expect = 6e-04
Identities = 22/69 (31%), Positives = 39/69 (56%), Gaps = 5/69 (7%)
Query: 103 FLVEKHWYKQWEAYVQGGDQDSSTFPGCINNATLFQDEINWRLKEGLVEGEDYVLLPAAA 162
+ + W+++WEA+V+G D + PG I+N+ + Q + + ++ L +G DY +
Sbjct: 818 YCISMQWFREWEAFVKGKDNEP---PGPIDNSRIAQVKGSGHVQ--LKQGADYGQISEET 872
Query: 163 WHYLVSWYG 171
W YL S YG
Sbjct: 873 WTYLNSLYG 881
Score = 34.7 bits (78), Expect = 0.44
Identities = 18/43 (41%), Positives = 24/43 (55%)
Query: 447 KRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLP 489
++R SVI D F G S + C C VS T + F LS+P+P
Sbjct: 438 EQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480
>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 105 bits (263), Expect = 2e-22
Identities = 53/151 (35%), Positives = 85/151 (56%), Gaps = 3/151 (1%)
Query: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838
V L++C+ F + L+ +N + C CK+ + K + LPEIL IHLKRF +
Sbjct: 537 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596
Query: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898
K+++ V FP+ LD F+ + E ++ YDL++V H+G GHY + N +
Sbjct: 597 FKINSHVSFPLEGLDLRPFLAK---ECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVIN 653
Query: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQR 929
GQW+ FDD V+ V+E +++ YVLFY++
Sbjct: 654 GQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684
Score = 80.1 bits (196), Expect = 9e-15
Identities = 47/120 (39%), Positives = 67/120 (55%), Gaps = 8/120 (6%)
Query: 298 EDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGE 357
ED+D K + G+ G+ NLGN+C+MN+ALQ LSN P LT++FL L + K
Sbjct: 135 EDDDLKPR-GLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTD------KKPA 187
Query: 358 IAEAYADLVKQAWSGHHRS-IVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDL 416
+ ++Y LV + W S +VP + + F GY Q D+QE L L+D LHE+L
Sbjct: 188 LCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
Score = 44.3 bits (103), Expect = 6e-04
Identities = 22/69 (31%), Positives = 39/69 (56%), Gaps = 5/69 (7%)
Query: 103 FLVEKHWYKQWEAYVQGGDQDSSTFPGCINNATLFQDEINWRLKEGLVEGEDYVLLPAAA 162
+ + W+++WEA+V+G D + PG I+N+ + Q + + ++ L +G DY +
Sbjct: 818 YCISMQWFREWEAFVKGKDNEP---PGPIDNSRIAQVKGSGHVQ--LKQGADYGQISEET 872
Query: 163 WHYLVSWYG 171
W YL S YG
Sbjct: 873 WTYLNSLYG 881
Score = 34.7 bits (78), Expect = 0.44
Identities = 18/43 (41%), Positives = 24/43 (55%)
Query: 447 KRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLP 489
++R SVI D F G S + C C VS T + F LS+P+P
Sbjct: 438 EQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480
>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 105 bits (263), Expect = 2e-22
Identities = 53/151 (35%), Positives = 85/151 (56%), Gaps = 3/151 (1%)
Query: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838
V L++C+ F + L+ +N + C CK+ + K + LPEIL IHLKRF +
Sbjct: 537 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596
Query: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898
K+++ V FP+ LD F+ + E ++ YDL++V H+G GHY + N +
Sbjct: 597 FKINSHVSFPLEGLDLRPFLAK---ECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVIN 653
Query: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQR 929
GQW+ FDD V+ V+E +++ YVLFY++
Sbjct: 654 GQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684
Score = 80.1 bits (196), Expect = 9e-15
Identities = 47/120 (39%), Positives = 67/120 (55%), Gaps = 8/120 (6%)
Query: 298 EDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGE 357
ED+D K + G+ G+ NLGN+C+MN+ALQ LSN P LT++FL L + K
Sbjct: 135 EDDDLKPR-GLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTD------KKPA 187
Query: 358 IAEAYADLVKQAWSGHHRS-IVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDL 416
+ ++Y LV + W S +VP + + F GY Q D+QE L L+D LHE+L
Sbjct: 188 LCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247
Score = 44.3 bits (103), Expect = 6e-04
Identities = 22/69 (31%), Positives = 39/69 (56%), Gaps = 5/69 (7%)
Query: 103 FLVEKHWYKQWEAYVQGGDQDSSTFPGCINNATLFQDEINWRLKEGLVEGEDYVLLPAAA 162
+ + W+++WEA+V+G D + PG I+N+ + Q + + ++ L +G DY +
Sbjct: 818 YCISMQWFREWEAFVKGKDNEP---PGPIDNSRIAQVKGSGHVQ--LKQGADYGQISEET 872
Query: 163 WHYLVSWYG 171
W YL S YG
Sbjct: 873 WTYLNSLYG 881
Score = 34.7 bits (78), Expect = 0.44
Identities = 18/43 (41%), Positives = 24/43 (55%)
Query: 447 KRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLP 489
++R SVI D F G S + C C VS T + F LS+P+P
Sbjct: 438 EQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 95.9 bits (237), Expect = 2e-19
Identities = 53/164 (32%), Positives = 82/164 (50%), Gaps = 12/164 (7%)
Query: 781 LQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREK 840
L +C++ FT E L C SC+ +Q +TK+L + LP + HLKRF + R K
Sbjct: 549 LTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRRK 608
Query: 841 LDTLVEFPIRDLDFSEFVI----------QPQNESNPELYKYDLIAVSNHYGGMRDGHYT 890
++T + FP+ +LD + F+ QP + P KY L AV NH+G + GHYT
Sbjct: 609 INTFISFPL-ELDMTPFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGHYT 667
Query: 891 TFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQDVAR 934
+F + QW DD ++ + Y+LFY +Q + +
Sbjct: 668 SF-IRQQKDQWFSCDDAIITKATIEDLLYSEGYLLFYHKQGLEK 710
Score = 72.4 bits (176), Expect = 2e-12
Identities = 54/186 (29%), Positives = 82/186 (44%), Gaps = 30/186 (16%)
Query: 307 GICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNN---CYLEELNFRNPLGMKGEIAEAYA 363
G+ GL NLGNTCFMN +Q L+++P L ++FL++ C + + M +
Sbjct: 361 GLRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLCLVCEM--------S 412
Query: 364 DLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKE 423
L +SG +P+ + + A GY+Q D+ E L +LD LH
Sbjct: 413 SLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRH-------- 464
Query: 424 YVELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCY 483
D QEA N+ + +I F G +S + C C +VS T DP
Sbjct: 465 ---------SKDDSGGQEA--NNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWD 513
Query: 484 LSVPLP 489
+S+ LP
Sbjct: 514 ISLDLP 519
>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
Length = 438
Score = 89.7 bits (221), Expect = 1e-17
Identities = 53/162 (32%), Positives = 77/162 (47%), Gaps = 15/162 (9%)
Query: 781 LQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREK 840
L +C+ FT E L C SC+ +Q +TK+L + LP + H KRF ++ R K
Sbjct: 263 LTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRK 322
Query: 841 LDTLVEFPIRDLDFSEFVIQ------------PQNESNPELYKYDLIAVSNHYGGMRDGH 888
+ T + FP+ +LD + F+ P N N E KY L AV NH G + GH
Sbjct: 323 ITTYISFPL-ELDMTPFMASSKESRMNGQLQLPTNSGNNE-NKYSLFAVVNHQGTLESGH 380
Query: 889 YTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQ 930
YT+F QW DD ++ + + Y+LFY +Q
Sbjct: 381 YTSF-IRHHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQ 421
Score = 75.1 bits (183), Expect = 3e-13
Identities = 66/233 (28%), Positives = 102/233 (43%), Gaps = 31/233 (13%)
Query: 278 KKDGTWPSA--QLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTE 335
+K TW + +L ++ +N G+ GL NLGNTCFMN +Q L++ P L +
Sbjct: 45 EKFPTWETTKPELELLGHNPRRRRITSSFTIGLRGLINLGNTCFMNCIVQALTHTPILRD 104
Query: 336 YFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLG 395
+FL++ + E+ P + E + L ++ +SG+ VP+ + V A G
Sbjct: 105 FFLSDRHRCEM----PSPELCLVCE-MSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAG 159
Query: 396 YQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVIV 455
Y+Q D+ E L LD LH +V + A N+ + +I
Sbjct: 160 YRQQDAHEFLIAALDVLHRHCK-----------------GDDVGKAA--NNPNHCNCIID 200
Query: 456 DTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRK 508
F G +S + C C VS T DP +S+ LP S F PM P R+
Sbjct: 201 QIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSC-----TSFWPMSPGRE 248
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 87.8 bits (216), Expect = 4e-17
Identities = 53/162 (32%), Positives = 78/162 (48%), Gaps = 15/162 (9%)
Query: 781 LQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREK 840
L +C+ FT E L C C +Q +TK+L + LP + HLKRF ++ R K
Sbjct: 362 LTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRRK 421
Query: 841 LDTLVEFPIRDLDFSEFVI------------QPQNESNPELYKYDLIAVSNHYGGMRDGH 888
+ T V FP+ +LD + F+ QP + N + KY L AV NH G + GH
Sbjct: 422 ITTYVSFPL-ELDMTPFMASSKESRMNGQYQQPTDSLNND-NKYSLFAVVNHQGTLESGH 479
Query: 889 YTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQ 930
YT+F + QW DD ++ + + Y+LFY +Q
Sbjct: 480 YTSF-IRQHKDQWFKCDDAIITKASIKDVLDSEGYLLFYHKQ 520
Score = 81.6 bits (200), Expect = 3e-15
Identities = 62/240 (25%), Positives = 102/240 (42%), Gaps = 26/240 (10%)
Query: 252 DRLYDTHITVLDAALETGQLIIMETRKKDGTWPSA--QLHVMNNNMSEEDEDFKGQPGIC 309
D +YD + ++ + + +K TW +L ++ +N G+
Sbjct: 117 DYIYDKDMEIIAKEEQRKAWKMQGVGEKFSTWEPTKRELELLKHNPKRRKITSNCTIGLR 176
Query: 310 GLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQA 369
GL NLGNTCFMN +Q L++ P L ++FL++ + E+ + + + L ++
Sbjct: 177 GLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSC-----LVCEMSSLFQEF 231
Query: 370 WSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCD 429
+SGH +P+ + V A GY+Q D+ E L LD LH D
Sbjct: 232 YSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCKG----------D 281
Query: 430 AAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLP 489
G+ N+ + +I F G +S + C C VS T DPF +S+ LP
Sbjct: 282 DNGKK---------ANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLP 332
>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
Length = 822
Score = 85.1 bits (209), Expect = 3e-16
Identities = 67/233 (28%), Positives = 107/233 (45%), Gaps = 16/233 (6%)
Query: 272 IIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKG--QPGICGLTNLGNTCFMNSALQCLSN 329
I +E +K + + Q NM++E+ Q + GL+NLGNTCF N+ +Q LS
Sbjct: 156 IELENKKLEKESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQ 215
Query: 330 VPQLTEYF--------LNNCYLEELNFRNPLGMK----GEIAEAYADLVKQAWSGHHRSI 377
P L E + +L PL + G + A + + + +
Sbjct: 216 TPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVV 275
Query: 378 VPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLH-EDLNRVKKKEYVELCDAAGRPDQ 436
P ++V A +F GYQQ DSQELL +LLDG+ E+ RV K ++ + D+
Sbjct: 276 TPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDE 335
Query: 437 EVAQEAWQNHKRRNDSVIVD-TFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPL 488
E+ + K+++ VD F G S ++C C VS+ + F LS+P+
Sbjct: 336 ELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 388
Score = 70.1 bits (170), Expect = 9e-12
Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 42/190 (22%)
Query: 781 LQECIELFTTVETLEKENPWYCPSCKQHQL-----------------ATKKLDLWMLPEI 823
+Q C+ FT E L N C C + Q A K++ + + P +
Sbjct: 632 IQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPPV 691
Query: 824 LIIHLKRFSYTKFSREKLDTLVEFP-IRDL-DFSEFVIQPQNESNPELYKYDLIAVSNHY 881
L +HLKRF F+ K++ ++FP I DL F + E N + Y L V H
Sbjct: 692 LTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLKCKNVAEENTRVL-YSLYGVVEHS 750
Query: 882 GGMRDGHYTTFACNK----------------------DSGQWHYFDDNSVSPVNENQIES 919
G MR GHYT +A + GQW + D V V ++ +
Sbjct: 751 GTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLN 810
Query: 920 KAAYVLFYQR 929
AY+LFY+R
Sbjct: 811 SQAYLLFYER 820
>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 85.1 bits (209), Expect = 3e-16
Identities = 67/233 (28%), Positives = 107/233 (45%), Gaps = 16/233 (6%)
Query: 272 IIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKG--QPGICGLTNLGNTCFMNSALQCLSN 329
I +E +K + + Q NM++E+ Q + GL+NLGNTCF N+ +Q LS
Sbjct: 157 IELENKKLEKESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQ 216
Query: 330 VPQLTEYF--------LNNCYLEELNFRNPLGMK----GEIAEAYADLVKQAWSGHHRSI 377
P L E + +L PL + G + A + + + +
Sbjct: 217 TPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVV 276
Query: 378 VPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLH-EDLNRVKKKEYVELCDAAGRPDQ 436
P ++V A +F GYQQ DSQELL +LLDG+ E+ RV K ++ + D+
Sbjct: 277 TPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDE 336
Query: 437 EVAQEAWQNHKRRNDSVIVD-TFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPL 488
E+ + K+++ VD F G S ++C C VS+ + F LS+P+
Sbjct: 337 ELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 389
Score = 70.1 bits (170), Expect = 9e-12
Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 42/190 (22%)
Query: 781 LQECIELFTTVETLEKENPWYCPSCKQHQL-----------------ATKKLDLWMLPEI 823
+Q C+ FT E L N C C + Q A K++ + + P +
Sbjct: 633 IQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPPV 692
Query: 824 LIIHLKRFSYTKFSREKLDTLVEFP-IRDL-DFSEFVIQPQNESNPELYKYDLIAVSNHY 881
L +HLKRF F+ K++ ++FP I DL F + E N + Y L V H
Sbjct: 693 LTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLKCKNVAEENTRVL-YSLYGVVEHS 751
Query: 882 GGMRDGHYTTFACNK----------------------DSGQWHYFDDNSVSPVNENQIES 919
G MR GHYT +A + GQW + D V V ++ +
Sbjct: 752 GTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLN 811
Query: 920 KAAYVLFYQR 929
AY+LFY+R
Sbjct: 812 SQAYLLFYER 821
>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 85.1 bits (209), Expect = 3e-16
Identities = 67/233 (28%), Positives = 107/233 (45%), Gaps = 16/233 (6%)
Query: 272 IIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKG--QPGICGLTNLGNTCFMNSALQCLSN 329
I +E +K + + Q NM++E+ Q + GL+NLGNTCF N+ +Q LS
Sbjct: 157 IELENKKLEKESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQ 216
Query: 330 VPQLTEYF--------LNNCYLEELNFRNPLGMK----GEIAEAYADLVKQAWSGHHRSI 377
P L E + +L PL + G + A + + + +
Sbjct: 217 TPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVV 276
Query: 378 VPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLH-EDLNRVKKKEYVELCDAAGRPDQ 436
P ++V A +F GYQQ DSQELL +LLDG+ E+ RV K ++ + D+
Sbjct: 277 TPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDE 336
Query: 437 EVAQEAWQNHKRRNDSVIVD-TFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPL 488
E+ + K+++ VD F G S ++C C VS+ + F LS+P+
Sbjct: 337 ELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 389
Score = 70.1 bits (170), Expect = 9e-12
Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 42/190 (22%)
Query: 781 LQECIELFTTVETLEKENPWYCPSCKQHQL-----------------ATKKLDLWMLPEI 823
+Q C+ FT E L N C C + Q A K++ + + P +
Sbjct: 633 IQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPPV 692
Query: 824 LIIHLKRFSYTKFSREKLDTLVEFP-IRDL-DFSEFVIQPQNESNPELYKYDLIAVSNHY 881
L +HLKRF F+ K++ ++FP I DL F + E N + Y L V H
Sbjct: 693 LTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLKCKNVAEENTRVL-YSLYGVVEHS 751
Query: 882 GGMRDGHYTTFACNK----------------------DSGQWHYFDDNSVSPVNENQIES 919
G MR GHYT +A + GQW + D V V ++ +
Sbjct: 752 GTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLN 811
Query: 920 KAAYVLFYQR 929
AY+LFY+R
Sbjct: 812 SQAYLLFYER 821
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,247,209
Number of Sequences: 37866
Number of extensions: 2056430
Number of successful extensions: 12947
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 149
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 11503
Number of HSP's gapped (non-prelim): 1018
length of query: 963
length of database: 18,247,518
effective HSP length: 112
effective length of query: 851
effective length of database: 14,006,526
effective search space: 11919553626
effective search space used: 11919553626
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.