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Search of human proteins with 239757187
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239757187 PREDICTED: similar to growth differentiation
factor 15 [Homo sapiens]
(270 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239757187 PREDICTED: similar to growth differentiation factor... 562 e-160
gi|153792495 growth differentiation factor 15 [Homo sapiens] 450 e-127
gi|110349792 growth differentiation factor 1 [Homo sapiens] 80 2e-15
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 80 2e-15
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 77 2e-14
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 75 5e-14
gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 75 5e-14
gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 74 2e-13
gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 71 9e-13
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 71 1e-12
gi|13899338 activin beta E [Homo sapiens] 70 1e-12
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens] 69 3e-12
gi|7705308 growth differentiation factor 2 [Homo sapiens] 69 6e-12
gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 68 7e-12
gi|222352098 nodal precursor [Homo sapiens] 67 2e-11
gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 63 3e-10
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ... 62 5e-10
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa... 62 5e-10
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] 61 1e-09
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 60 2e-09
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 60 2e-09
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 60 2e-09
gi|4507465 transforming growth factor, beta 3 [Homo sapiens] 60 2e-09
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 59 6e-09
gi|4826740 growth differentiation factor 10 precursor [Homo sapi... 58 8e-09
gi|63025222 transforming growth factor, beta 1 [Homo sapiens] 58 1e-08
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 58 1e-08
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 56 4e-08
gi|4504699 inhibin beta A precursor [Homo sapiens] 54 1e-07
gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 53 3e-07
>gi|239757187 PREDICTED: similar to growth differentiation factor 15
[Homo sapiens]
Length = 270
Score = 562 bits (1449), Expect = e-160
Identities = 270/270 (100%), Positives = 270/270 (100%)
Query: 1 MLSDAADVTDVVGGTLRGHPDSADPAWRVRGNGHPRSWKTVGLWVTSFPICLPTVRLGSG 60
MLSDAADVTDVVGGTLRGHPDSADPAWRVRGNGHPRSWKTVGLWVTSFPICLPTVRLGSG
Sbjct: 1 MLSDAADVTDVVGGTLRGHPDSADPAWRVRGNGHPRSWKTVGLWVTSFPICLPTVRLGSG 60
Query: 61 GHLHLRISRAALPEGLPEASRLHRALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLR 120
GHLHLRISRAALPEGLPEASRLHRALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLR
Sbjct: 61 GHLHLRISRAALPEGLPEASRLHRALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLR 120
Query: 121 LSPPPSQSDQLLAESSSARPQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRA 180
LSPPPSQSDQLLAESSSARPQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRA
Sbjct: 121 LSPPPSQSDQLLAESSSARPQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRA 180
Query: 181 SLEDLGWADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPAS 240
SLEDLGWADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPAS
Sbjct: 181 SLEDLGWADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPAS 240
Query: 241 YNPMVLIQKTDTGVSLQTYDDLLAKDCHCI 270
YNPMVLIQKTDTGVSLQTYDDLLAKDCHCI
Sbjct: 241 YNPMVLIQKTDTGVSLQTYDDLLAKDCHCI 270
>gi|153792495 growth differentiation factor 15 [Homo sapiens]
Length = 308
Score = 450 bits (1158), Expect = e-127
Identities = 224/246 (91%), Positives = 228/246 (92%), Gaps = 6/246 (2%)
Query: 28 RVRGNGHPRSWKTVGLWVTSFP---ICLPTVRLGSGGHLHLRISRAALPEGLPEASRLHR 84
R+R N +SW+ + P I P VRLGSGGHLHLRISRAALPEGLPEASRLHR
Sbjct: 66 RLRAN---QSWEDSNTDLVPAPAVRILTPEVRLGSGGHLHLRISRAALPEGLPEASRLHR 122
Query: 85 ALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQLEL 144
ALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQLEL
Sbjct: 123 ALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQLEL 182
Query: 145 HLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIG 204
HLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIG
Sbjct: 183 HLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIG 242
Query: 205 ACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLA 264
ACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLA
Sbjct: 243 ACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLA 302
Query: 265 KDCHCI 270
KDCHCI
Sbjct: 303 KDCHCI 308
>gi|110349792 growth differentiation factor 1 [Homo sapiens]
Length = 372
Score = 80.1 bits (196), Expect = 2e-15
Identities = 61/182 (33%), Positives = 80/182 (43%), Gaps = 26/182 (14%)
Query: 96 SWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQLELHLRPQAARGRR 155
SW R LR L+L RP+APA RL AE+S L+ L AR RR
Sbjct: 208 SWP--RSLRLALAL-RPRAPAACARL-----------AEASLLLVTLDPRLCHPLARPRR 253
Query: 156 RARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACP-------S 208
A G GPG CR + S ++GW WV++PR C G C S
Sbjct: 254 DAEPVLGG----GPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGS 309
Query: 209 QFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDC 267
A HA ++ +H P PCCVPA +P+ VL V L+ Y+D++ +C
Sbjct: 310 GGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDEC 369
Query: 268 HC 269
C
Sbjct: 370 GC 371
>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
sapiens]
Length = 513
Score = 79.7 bits (195), Expect = 2e-15
Identities = 45/146 (30%), Positives = 71/146 (48%), Gaps = 19/146 (13%)
Query: 143 ELHLRP-QAARGRRRARARN--------------GDHCPLGPGRCCRLHTVRASLEDLGW 187
E+H+R ++A RRR ++RN D+ CR H + S +DLGW
Sbjct: 367 EVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDLGW 426
Query: 188 ADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPM 244
DW+++P+ C G C A A HA ++T +H + P+ VP PCC P N +
Sbjct: 427 QDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAI 486
Query: 245 -VLIQKTDTGVSLQTYDDLLAKDCHC 269
VL ++ V L+ Y +++ + C C
Sbjct: 487 SVLYFDDNSNVILKKYRNMVVRACGC 512
>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
sapiens]
Length = 454
Score = 76.6 bits (187), Expect = 2e-14
Identities = 44/145 (30%), Positives = 66/145 (45%), Gaps = 18/145 (12%)
Query: 143 ELHLRPQAARGRRRARARN--------------GDHCPLGPGRCCRLHTVRASLEDLGWA 188
E+ LR A +R+ + RN GD+ + C+ H + S DLGW
Sbjct: 309 EVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQ 368
Query: 189 DWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPM- 244
DW+++P C G C A A HA ++T +H + PD VP PCC P N +
Sbjct: 369 DWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAIS 428
Query: 245 VLIQKTDTGVSLQTYDDLLAKDCHC 269
VL + V L+ Y +++ + C C
Sbjct: 429 VLYFDDSSNVILKKYRNMVVRSCGC 453
>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
Length = 431
Score = 75.5 bits (184), Expect = 5e-14
Identities = 34/103 (33%), Positives = 54/103 (52%), Gaps = 4/103 (3%)
Query: 171 RCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACP---SQFRAANMHAQIKTSLHRLK 227
+ C+ H + S DLGW DW+++P C G C + + A HA ++T +H +
Sbjct: 328 QACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFIN 387
Query: 228 PDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 269
P+TVP PCC P N + VL + V L+ Y +++ + C C
Sbjct: 388 PETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
>gi|61835232 growth differentiation factor 7 preproprotein [Homo
sapiens]
Length = 450
Score = 75.5 bits (184), Expect = 5e-14
Identities = 57/197 (28%), Positives = 86/197 (43%), Gaps = 23/197 (11%)
Query: 84 RALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQLE 143
RA+ +S R + R +R Q AR AL P P + +A P+
Sbjct: 265 RAVLVVSSRTQRKESLFREIRAQ---ARALGAALASEPLPDPG--------TGTASPRAV 313
Query: 144 L---HLRPQAARGRRRARARNGD----HCPLGPGRCCRLHTVRASLEDLGWADWVLSPRE 196
+ R A G R A+ G H G RC R + ++LGW DW+++P +
Sbjct: 314 IGGRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSR-KPLHVDFKELGWDDWIIAPLD 372
Query: 197 VQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPM-VLIQKTDT 252
+ C G C R+ HA I+T L+ + PD PA CCVPA +P+ +L
Sbjct: 373 YEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAAN 432
Query: 253 GVSLQTYDDLLAKDCHC 269
V + Y+D++ + C C
Sbjct: 433 NVVYKQYEDMVVEACGC 449
>gi|48475062 growth differentiation factor 6 precursor [Homo
sapiens]
Length = 455
Score = 73.6 bits (179), Expect = 2e-13
Identities = 52/185 (28%), Positives = 80/185 (43%), Gaps = 19/185 (10%)
Query: 92 TASRSWDVTRPLRRQLSLARPQAPALHLRLS-PPPSQSDQLLAESSSARPQLELHLRPQA 150
T S+ ++ +R QL A P S PPPS + ARP L P
Sbjct: 282 TRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPD-------ARPWL-----PSP 329
Query: 151 ARGRRRAR--ARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPS 208
R RRR +R+G C + + ++LGW DW+++P E + C G C
Sbjct: 330 GRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDF 389
Query: 209 QFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLA 264
R+ HA I+T ++ + P + P CCVP P+ +L V + Y+D++
Sbjct: 390 PLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVV 449
Query: 265 KDCHC 269
+ C C
Sbjct: 450 ESCGC 454
>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
Length = 402
Score = 71.2 bits (173), Expect = 9e-13
Identities = 41/140 (29%), Positives = 65/140 (46%), Gaps = 18/140 (12%)
Query: 148 PQAARGRRRARARNGDHCPLG---PG-----------RCCRLHTVRASLEDLGWADWVLS 193
P+A R RR + + + P PG + CR H + S +DLGW DWV++
Sbjct: 262 PRAVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGRQVCRRHELYVSFQDLGWLDWVIA 321
Query: 194 PREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYN-PMVLIQK 249
P+ C G C + A HA +++ +H +KP+ VP CC P + VL
Sbjct: 322 PQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYD 381
Query: 250 TDTGVSLQTYDDLLAKDCHC 269
+ V L+ + +++ K C C
Sbjct: 382 SSNNVILRKHRNMVVKACGC 401
>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
sapiens]
Length = 402
Score = 70.9 bits (172), Expect = 1e-12
Identities = 41/140 (29%), Positives = 64/140 (45%), Gaps = 18/140 (12%)
Query: 148 PQAARGRRRARARNGDHCPLG---PG-----------RCCRLHTVRASLEDLGWADWVLS 193
P+A R RR + + + P PG + CR H + S +DLGW DWV++
Sbjct: 262 PRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIA 321
Query: 194 PREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYN-PMVLIQK 249
P+ C G C + A HA +++ +H + PD VP CC P + VL
Sbjct: 322 PQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYD 381
Query: 250 TDTGVSLQTYDDLLAKDCHC 269
+ V L+ + +++ K C C
Sbjct: 382 SSNNVILRKHRNMVVKACGC 401
>gi|13899338 activin beta E [Homo sapiens]
Length = 350
Score = 70.5 bits (171), Expect = 1e-12
Identities = 47/149 (31%), Positives = 67/149 (44%), Gaps = 9/149 (6%)
Query: 127 QSDQLLAESSSARPQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLG 186
Q +LL + +P LEL +R G RAR R P P C R H V ++LG
Sbjct: 204 QPRRLLDTAGHQQPFLELKIRANEP-GAGRARRRTPTCEPATPLCCRRDHYV--DFQELG 260
Query: 187 WADWVLSPREVQVTMCIGACPSQFR-----AANMHAQIKTSLHRLKPDTVPAPCCVPASY 241
W DW+L P Q+ C G CP AA+ H+ + + L P CCVP +
Sbjct: 261 WRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPASTSCCVPTAR 320
Query: 242 NPMVLIQKTDTGVSLQT-YDDLLAKDCHC 269
P+ L+ G ++T D++ + C C
Sbjct: 321 RPLSLLYLDHNGNVVKTDVPDMVVEACGC 349
>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
Length = 454
Score = 69.3 bits (168), Expect = 3e-12
Identities = 32/105 (30%), Positives = 52/105 (49%), Gaps = 4/105 (3%)
Query: 169 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACP---SQFRAANMHAQIKTSLHR 225
P C LH R S L W +W+++P C G CP + +H ++ ++
Sbjct: 349 PQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYE 408
Query: 226 LKPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 269
+VP P CVPA Y+P+ VL + D ++ + Y+D++A C C
Sbjct: 409 KLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
>gi|7705308 growth differentiation factor 2 [Homo sapiens]
Length = 429
Score = 68.6 bits (166), Expect = 6e-12
Identities = 39/142 (27%), Positives = 64/142 (45%), Gaps = 13/142 (9%)
Query: 133 AESSSARPQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVL 192
A SS + H+ + RR+ A G HC + ++R + ED+GW W++
Sbjct: 295 AGESSHEEDTDGHVAAGSTLARRKRSAGAGSHC--------QKTSLRVNFEDIGWDSWII 346
Query: 193 SPREVQVTMCIGAC---PSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQK 249
+P+E + C G C + HA ++T +H P V CCVP +P+ ++ K
Sbjct: 347 APKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYK 406
Query: 250 TDTGVSL--QTYDDLLAKDCHC 269
D GV Y+ + +C C
Sbjct: 407 DDMGVPTLKYHYEGMSVAECGC 428
>gi|4503969 growth differentiation factor 5 preproprotein [Homo
sapiens]
Length = 501
Score = 68.2 bits (165), Expect = 7e-12
Identities = 36/145 (24%), Positives = 66/145 (45%), Gaps = 4/145 (2%)
Query: 129 DQLLAESSSARPQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWA 188
+++ A S + +L Q + R R G C + + +D+GW
Sbjct: 356 NEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWD 415
Query: 189 DWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPM- 244
DW+++P E + C G C R+ HA I+T ++ + P++ P CCVP +P+
Sbjct: 416 DWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475
Query: 245 VLIQKTDTGVSLQTYDDLLAKDCHC 269
+L + V + Y+D++ + C C
Sbjct: 476 ILFIDSANNVVYKQYEDMVVESCGC 500
>gi|222352098 nodal precursor [Homo sapiens]
Length = 347
Score = 67.0 bits (162), Expect = 2e-11
Identities = 34/122 (27%), Positives = 57/122 (46%), Gaps = 10/122 (8%)
Query: 153 GRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPS---- 208
G+R R D L CR + +GW W++ P++ C G CP+
Sbjct: 232 GKRHRRHHLPDRSQL-----CRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGE 286
Query: 209 QFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAKDCH 268
+F N HA I++ L R +P VP+ CC P P+ ++ + V L + D++ ++C
Sbjct: 287 EFHPTN-HAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLDHHKDMIVEECG 345
Query: 269 CI 270
C+
Sbjct: 346 CL 347
>gi|10190670 growth differentiation factor 3 precursor [Homo
sapiens]
Length = 364
Score = 62.8 bits (151), Expect = 3e-10
Identities = 39/150 (26%), Positives = 68/150 (45%), Gaps = 19/150 (12%)
Query: 134 ESSSARPQLELH-------LRPQAARGRRRARARNGDHCPLGPGRC---CRLHTVRASLE 183
E + AR + LH L P R+ RA P+ C C H + +
Sbjct: 219 EDTCARLRCSLHASLLVVTLNPDQCHPSRKRRAA----IPVPKLSCKNLCHRHQLFINFR 274
Query: 184 DLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPAS 240
DLGW W+++P+ C G CP ++ +A ++ +H + P+ +P C+P
Sbjct: 275 DLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPE-IPQAVCIPTK 333
Query: 241 YNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 269
+P+ +L Q + V L+ Y+D++ +C C
Sbjct: 334 LSPISMLYQDNNDNVILRHYEDMVVDECGC 363
>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
sapiens]
Length = 442
Score = 62.0 bits (149), Expect = 5e-10
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 7/142 (4%)
Query: 134 ESSSARPQLELHLRPQ-----AARGRRRARARNGDHCPLGPGRCCRLHTVRASLE-DLGW 187
++S P L L L P RR+ RA + +C C L + + DLGW
Sbjct: 301 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 360
Query: 188 ADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLI 247
W+ P+ C GACP + + H+++ + + + P+ +PCCV P+ ++
Sbjct: 361 K-WIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTIL 419
Query: 248 QKTDTGVSLQTYDDLLAKDCHC 269
++ +++ K C C
Sbjct: 420 YYIGKTPKIEQLSNMIVKSCKC 441
>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
sapiens]
Length = 414
Score = 62.0 bits (149), Expect = 5e-10
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 7/142 (4%)
Query: 134 ESSSARPQLELHLRPQ-----AARGRRRARARNGDHCPLGPGRCCRLHTVRASLE-DLGW 187
++S P L L L P RR+ RA + +C C L + + DLGW
Sbjct: 273 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 332
Query: 188 ADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLI 247
W+ P+ C GACP + + H+++ + + + P+ +PCCV P+ ++
Sbjct: 333 K-WIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTIL 391
Query: 248 QKTDTGVSLQTYDDLLAKDCHC 269
++ +++ K C C
Sbjct: 392 YYIGKTPKIEQLSNMIVKSCKC 413
>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
Length = 392
Score = 60.8 bits (146), Expect = 1e-09
Identities = 31/101 (30%), Positives = 51/101 (50%), Gaps = 4/101 (3%)
Query: 173 CRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFR---AANMHAQIKTSLHRLKPD 229
C LH + S LGW W+++P C G C R + HA I+ +++L
Sbjct: 291 CSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQ 350
Query: 230 TVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 269
+VP P CVP Y P+ VL+ + + + + Y+ ++A+ C C
Sbjct: 351 SVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391
>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 60.5 bits (145), Expect = 2e-09
Identities = 34/129 (26%), Positives = 61/129 (47%), Gaps = 7/129 (5%)
Query: 147 RPQAARGRRRARARNGDHCPLG--PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIG 204
R A RRRA+ H + CR H++ D+GW DW+++P Q C G
Sbjct: 280 RGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHG 339
Query: 205 ACP---SQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTD-TGVSLQTYD 260
CP + + HA ++T ++ + ++P CCVP + + ++ + V L+ Y
Sbjct: 340 DCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQ 398
Query: 261 DLLAKDCHC 269
+++ + C C
Sbjct: 399 EMVVEGCGC 407
>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 60.5 bits (145), Expect = 2e-09
Identities = 34/129 (26%), Positives = 61/129 (47%), Gaps = 7/129 (5%)
Query: 147 RPQAARGRRRARARNGDHCPLG--PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIG 204
R A RRRA+ H + CR H++ D+GW DW+++P Q C G
Sbjct: 280 RGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHG 339
Query: 205 ACP---SQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTD-TGVSLQTYD 260
CP + + HA ++T ++ + ++P CCVP + + ++ + V L+ Y
Sbjct: 340 DCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQ 398
Query: 261 DLLAKDCHC 269
+++ + C C
Sbjct: 399 EMVVEGCGC 407
>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 60.5 bits (145), Expect = 2e-09
Identities = 34/129 (26%), Positives = 61/129 (47%), Gaps = 7/129 (5%)
Query: 147 RPQAARGRRRARARNGDHCPLG--PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIG 204
R A RRRA+ H + CR H++ D+GW DW+++P Q C G
Sbjct: 280 RGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHG 339
Query: 205 ACP---SQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTD-TGVSLQTYD 260
CP + + HA ++T ++ + ++P CCVP + + ++ + V L+ Y
Sbjct: 340 DCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQ 398
Query: 261 DLLAKDCHC 269
+++ + C C
Sbjct: 399 EMVVEGCGC 407
>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
Length = 412
Score = 60.1 bits (144), Expect = 2e-09
Identities = 31/118 (26%), Positives = 51/118 (43%), Gaps = 2/118 (1%)
Query: 153 GRRRARARNGDHCPLG-PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFR 211
G+R+ RA + ++C CC +DLGW WV P+ C G CP
Sbjct: 295 GQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRS 353
Query: 212 AANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAKDCHC 269
A H+ + + L P+ +PCCVP P+ ++ ++ +++ K C C
Sbjct: 354 ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKC 411
>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
sapiens]
Length = 472
Score = 58.5 bits (140), Expect = 6e-09
Identities = 30/107 (28%), Positives = 54/107 (50%), Gaps = 8/107 (7%)
Query: 169 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGAC----PSQFRAANMHAQIKTSLH 224
P C R + ++ D+GW++W++SP+ C GAC P + +N HA I++ +
Sbjct: 367 PRNCARRY-LKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSN-HATIQSIVR 424
Query: 225 RL-KPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 269
+ +P PCCVP + + +L + V L+ Y ++ + C C
Sbjct: 425 AVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
>gi|4826740 growth differentiation factor 10 precursor [Homo
sapiens]
Length = 478
Score = 58.2 bits (139), Expect = 8e-09
Identities = 32/105 (30%), Positives = 50/105 (47%), Gaps = 7/105 (6%)
Query: 171 RCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGAC----PSQFRAANMHAQIKTSLHRL 226
R C ++ D+GW +W++SP+ C GAC P R +N HA I++ + +
Sbjct: 374 RVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSN-HATIQSIVRAV 432
Query: 227 K-PDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 269
+P PCCVP N + VL + V L+ Y ++ C C
Sbjct: 433 GIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
>gi|63025222 transforming growth factor, beta 1 [Homo sapiens]
Length = 390
Score = 57.8 bits (138), Expect = 1e-08
Identities = 28/124 (22%), Positives = 54/124 (43%), Gaps = 2/124 (1%)
Query: 147 RPQAARGRRRARARNGDHCPLGPGR-CCRLHTVRASLEDLGWADWVLSPREVQVTMCIGA 205
R Q + R RA + ++C + CC +DLGW W+ P+ C+G
Sbjct: 267 RAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGP 325
Query: 206 CPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAK 265
CP + ++++ ++ P APCCVP + P+ ++ ++ +++ +
Sbjct: 326 CPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVR 385
Query: 266 DCHC 269
C C
Sbjct: 386 SCKC 389
>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
Length = 352
Score = 57.8 bits (138), Expect = 1e-08
Identities = 44/164 (26%), Positives = 68/164 (41%), Gaps = 20/164 (12%)
Query: 117 LHLRLSPPPSQSDQLLAESSSARPQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLH 176
L L L +QS +L ++ RP + +R G + R G C G CCR
Sbjct: 197 LELVLEGQVAQSSVILG-GAAHRPFVAARVRV----GGKHQIHRRGIDCQGGSRMCCRQE 251
Query: 177 TVRASLEDLGWADWVLSPREVQVTMCIGACPSQFR-----AANMHAQIKTSLHRLKPDTV 231
++GW DW++ P + CIG CP AA+ H + L+ LK +T
Sbjct: 252 FF-VDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAV---LNLLKANTA 307
Query: 232 P-----APCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 269
CCVP + P+ +L D+ + D++ + C C
Sbjct: 308 AGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351
>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
sapiens]
Length = 396
Score = 55.8 bits (133), Expect = 4e-08
Identities = 27/101 (26%), Positives = 49/101 (48%), Gaps = 5/101 (4%)
Query: 173 CRLHTVRASLEDLGWADWVLSPREVQVTMCIGACP---SQFRAANMHAQIKTSLHRLKPD 229
C+ H + D+GW DW+++P C G CP + + HA ++T ++ +
Sbjct: 296 CKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-S 354
Query: 230 TVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 269
+P CCVP + + +L + V L+ Y D++ + C C
Sbjct: 355 KIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395
>gi|4504699 inhibin beta A precursor [Homo sapiens]
Length = 426
Score = 54.3 bits (129), Expect = 1e-07
Identities = 37/145 (25%), Positives = 61/145 (42%), Gaps = 13/145 (8%)
Query: 134 ESSSARPQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLS 193
+ S RP L L R RR R G C CC+ S +D+GW DW+++
Sbjct: 285 KEQSHRPFLMLQARQSEDHPHRRRR--RGLECDGKVNICCKKQFF-VSFKDIGWNDWIIA 341
Query: 194 PREVQVTMCIGACPSQF-----RAANMHAQIKTSLHRLK---PDTVPAPCCVPASYNPMV 245
P C G CPS + + H+ + + +R++ P CCVP PM
Sbjct: 342 PSGYHANYCEGECPSHIAGTSGSSLSFHSTV-INHYRMRGHSPFANLKSCCVPTKLRPMS 400
Query: 246 LIQKTD-TGVSLQTYDDLLAKDCHC 269
++ D + + +++ ++C C
Sbjct: 401 MLYYDDGQNIIKKDIQNMIVEECGC 425
>gi|5031613 growth differentiation factor 11 precursor [Homo
sapiens]
Length = 407
Score = 52.8 bits (125), Expect = 3e-07
Identities = 29/112 (25%), Positives = 46/112 (41%), Gaps = 7/112 (6%)
Query: 140 PQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQV 199
P +EL + R RR +H RCCR + + E GW DW+++P+ +
Sbjct: 283 PFMELRVLENTKRSRRNLGLDCDEHS--SESRCCR-YPLTVDFEAFGW-DWIIAPKRYKA 338
Query: 200 TMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTD 251
C G C F H + + + P PCC P +P+ ++ D
Sbjct: 339 NYCSGQCEYMFMQKYPHTHL---VQQANPRGSAGPCCTPTKMSPINMLYFND 387
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.135 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,147,722
Number of Sequences: 37866
Number of extensions: 600495
Number of successful extensions: 2005
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 1930
Number of HSP's gapped (non-prelim): 89
length of query: 270
length of database: 18,247,518
effective HSP length: 101
effective length of query: 169
effective length of database: 14,423,052
effective search space: 2437495788
effective search space used: 2437495788
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.