Guide to the Human Genome
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Search of human proteins with 239757130

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
         (855 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...  1731   0.0  
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...  1625   0.0  
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...  1037   0.0  
gi|163965366 nascent polypeptide-associated complex alpha subuni...   211   2e-54
gi|116284392 mucin 2 precursor [Homo sapiens]                         165   2e-40
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]        153   6e-37
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                  152   2e-36
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                  152   2e-36
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                  152   2e-36
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                   152   2e-36
gi|47132519 Ras association and pleckstrin homology domains 1 is...   150   4e-36
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...   146   9e-35
gi|112421108 capicua homolog [Homo sapiens]                           144   3e-34
gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]        141   2e-33
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]      140   5e-33
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]             140   5e-33
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]         138   2e-32
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]         138   2e-32
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]         138   2e-32
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...   138   2e-32
gi|110832843 TBP-associated factor 4 [Homo sapiens]                   137   4e-32
gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapi...   133   6e-31
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...   131   3e-30
gi|239508790 PREDICTED: hypothetical protein, partial [Homo sapi...   130   5e-30
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]        130   7e-30
gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Hom...   128   2e-29
gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Hom...   128   2e-29
gi|160707881 formin 2 [Homo sapiens]                                  126   7e-29
gi|150170670 piccolo isoform 2 [Homo sapiens]                         124   3e-28
gi|150378539 piccolo isoform 1 [Homo sapiens]                         124   3e-28

>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 1731 bits (4482), Expect = 0.0
 Identities = 855/855 (100%), Positives = 855/855 (100%)

Query: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60
           MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE
Sbjct: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60

Query: 61  RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA 120
           RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA
Sbjct: 61  RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA 120

Query: 121 SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 180
           SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS
Sbjct: 121 SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 180

Query: 181 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 240
           RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR
Sbjct: 181 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 240

Query: 241 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300
           SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS
Sbjct: 241 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300

Query: 301 SSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT 360
           SSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT
Sbjct: 301 SSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT 360

Query: 361 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 420
           PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL
Sbjct: 361 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 420

Query: 421 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ 480
           ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ
Sbjct: 421 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ 480

Query: 481 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG 540
           VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG
Sbjct: 481 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG 540

Query: 541 QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSG 600
           QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSG
Sbjct: 541 QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSG 600

Query: 601 PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPD 660
           PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPD
Sbjct: 601 PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPD 660

Query: 661 AELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 720
           AELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG
Sbjct: 661 AELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 720

Query: 721 ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAE 780
           ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAE
Sbjct: 721 ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAE 780

Query: 781 GAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVA 840
           GAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVA
Sbjct: 781 GAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVA 840

Query: 841 SPQGDWTVVEVETFH 855
           SPQGDWTVVEVETFH
Sbjct: 841 SPQGDWTVVEVETFH 855


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 1625 bits (4207), Expect = 0.0
 Identities = 813/855 (95%), Positives = 814/855 (95%), Gaps = 39/855 (4%)

Query: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60
           MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE
Sbjct: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60

Query: 61  RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA 120
           RAGGIGGATIPESAPRAGPTR+         SRPPASGRGERAPPAKNTSPGPVSSPGRA
Sbjct: 61  RAGGIGGATIPESAPRAGPTRT---------SRPPASGRGERAPPAKNTSPGPVSSPGRA 111

Query: 121 SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 180
           SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS
Sbjct: 112 SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 171

Query: 181 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 240
           RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR
Sbjct: 172 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 231

Query: 241 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300
           SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS
Sbjct: 232 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 291

Query: 301 SSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT 360
           SSPLAT                              P P APPSPSAPPSLQTLPSPPAT
Sbjct: 292 SSPLAT------------------------------PSPSAPPSPSAPPSLQTLPSPPAT 321

Query: 361 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 420
           PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL
Sbjct: 322 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 381

Query: 421 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ 480
           ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ
Sbjct: 382 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ 441

Query: 481 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG 540
           VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG
Sbjct: 442 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG 501

Query: 541 QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSG 600
           QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSG
Sbjct: 502 QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSG 561

Query: 601 PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPD 660
           PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPD
Sbjct: 562 PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPD 621

Query: 661 AELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 720
           AELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG
Sbjct: 622 AELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 681

Query: 721 ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAE 780
           ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAE
Sbjct: 682 ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAE 741

Query: 781 GAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVA 840
           GAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVA
Sbjct: 742 GAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVA 801

Query: 841 SPQGDWTVVEVETFH 855
           SPQGDWTVVEVETFH
Sbjct: 802 SPQGDWTVVEVETFH 816


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score = 1037 bits (2682), Expect = 0.0
 Identities = 607/990 (61%), Positives = 644/990 (65%), Gaps = 155/990 (15%)

Query: 11   GAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATI 70
            G A   P   A      R    P P  P +PA  R   AAG     P   R         
Sbjct: 145  GKATEAPKRSALSAGARRDTSGPTPGTP-SPAMARRSRAAGTEVGLP---RPAPSARPRP 200

Query: 71   PESAPRAGPTRSAGTSSRNP---ASRPPASGRGERAPPAKNTSPG--PVSSPGR----AS 121
            P   PR   + ++  S+  P   A R P++G G + P +++ S    P+SSP R    A 
Sbjct: 201  PTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSAR 260

Query: 122  GTTR----PGPLGQKGLRISAEETVARGKATEAPKRSALSAG--ARRDTSG----PTP-- 169
            GT R    P     KGL+      V   +   AP    LS+   A    SG    P P  
Sbjct: 261  GTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPP 320

Query: 170  ---GTPSPAMARRSRAAGTEVGLPRPAPSARPR----------PPTEGPRKSVSSASE-- 214
                TP PA    S    T + L  P+PSA P           PP++ P    +   +  
Sbjct: 321  DNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAP 380

Query: 215  ------------HSTTEPSPAARRRPSAGGGLQRPASR---SLSSSATPLSSPARSGPSA 259
                        HS T PS  A   P A   LQ   S    +L ++ + L+   R   ++
Sbjct: 381  PSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQAS 440

Query: 260  RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS----------SPLATPSP 309
              +P  PA      P     L  P   P +   +PA+ PLSS          S LA+ SP
Sbjct: 441  LTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSP 500

Query: 310  SAALQSQ-----------APPTL---PA--------------------------TPHSSS 329
             A L S            APP+L   PA                          TPH  +
Sbjct: 501  QAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLET 560

Query: 330  LTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPL 389
              C    PL  APPSP   P  +T PS  ATPP QA  +L SP LQ     LPSPPLSPL
Sbjct: 561  PPCPAPCPLQ-APPSPLTTPPPET-PSSIATPPPQAPPALASPPLQG----LPSPPLSPL 614

Query: 390  ATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ 449
            ATPPPQAPP LALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ
Sbjct: 615  ATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ 674

Query: 450  APFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPP 509
            APFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPP
Sbjct: 675  APFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPP 734

Query: 510  LQ--------------------------------------------LAKPPPQAPPALAT 525
            LQ                                            LAKPPPQAPPALAT
Sbjct: 735  LQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALAT 794

Query: 526  PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585
            PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA
Sbjct: 795  PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 854

Query: 586  PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGY 645
            PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGY
Sbjct: 855  PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGY 914

Query: 646  DSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCT 705
            DSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCT
Sbjct: 915  DSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCT 974

Query: 706  IYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASV 765
            IYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASV
Sbjct: 975  IYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASV 1034

Query: 766  VQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESR 825
            VQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESR
Sbjct: 1035 VQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESR 1094

Query: 826  ASITSVTSFSPDDVASPQGDWTVVEVETFH 855
            ASITSVTSFSPDDVASPQGDWTVVEVETFH
Sbjct: 1095 ASITSVTSFSPDDVASPQGDWTVVEVETFH 1124



 Score =  904 bits (2335), Expect = 0.0
 Identities = 560/968 (57%), Positives = 589/968 (60%), Gaps = 181/968 (18%)

Query: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60
           MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE
Sbjct: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60

Query: 61  RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA 120
           RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA
Sbjct: 61  RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA 120

Query: 121 SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 180
           SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS
Sbjct: 121 SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 180

Query: 181 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 240
           RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR
Sbjct: 181 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 240

Query: 241 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300
           SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS
Sbjct: 241 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300

Query: 301 SSPLATPSPSAA-LQSQAPPTLPATPHSSSL--TCQLATPLPLAPPSPSAPPSLQTLPSP 357
           SSPLATPSPS    +   PP   ATP  ++L  +  LATPLPLAPPSPSAPPSLQTLPSP
Sbjct: 301 SSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSP 360

Query: 358 PATPPS----------------------------------------------QATTSLGS 371
           PATPPS                                              QATTSLGS
Sbjct: 361 PATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGS 420

Query: 372 PTLQATHSFL-------------PSPPLS-PLATPPPQAPPAL-ALPPLQAPPSPPASPP 416
           PTLQATHSFL             PS P S P  +PP QAP +L A PPLQ   SP  SP 
Sbjct: 421 PTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPL 480

Query: 417 LSPLATPSPQAPNALAVHLLQAPFS-------------PPPS------------------ 445
            SPL     QA ++LA H  QAP S              PPS                  
Sbjct: 481 SSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPS 540

Query: 446 ---PPVQAPFSP---------------PASPPVSPSATPPSQAPPSLAAPPLQVPP---S 484
              PP+Q   +P               P   P SP  TPP + P S+A PP Q PP   S
Sbjct: 541 LAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALAS 600

Query: 485 PP----ASPPMSPSATPPPQAPPPLAAPPLQ-------------LAKPPPQAPPALATPP 527
           PP     SPP+SP ATPPPQAPP LA PPLQ             LA P PQAP ALA   
Sbjct: 601 PPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHL 660

Query: 528 LQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPR 587
           LQA  SPP S P QAPFSP AS P+SP ATPP QAPP LAAP LQVPPSPPASP +    
Sbjct: 661 LQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSA 720

Query: 588 RPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSST--------LSGPDLAGHSSSATSTP 639
            PP   P    + P   L + P PP  P  SPS+T        L+ P L    S   S P
Sbjct: 721 TPPPQAPPPLAAPP---LQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLP 777

Query: 640 EELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRG----APGAPLPWPP-A 694
                          A PPP A  A   P   +  P+PP +F G    +P A LP  P A
Sbjct: 778 M-----------SPLAKPPPQAPPALATPPLQAL-PSPPASFPGQAPFSPSASLPMSPLA 825

Query: 695 TGPGSADGLCTIYETEGPESATPAPGAL------DPGPSPGTSGGKAAAGAGAG---ASS 745
           T P  A  +      + P S   +P          PGP    SG +       G     S
Sbjct: 826 TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 885

Query: 746 RSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAA 805
           RSP     G          +  H  S T   +  E   G   G  GGA          AA
Sbjct: 886 RSPSSTLSG--------PDLAGHSSSAT---STPEELRGYDSGPEGGAAASPPPDAELAA 934

Query: 806 LSDAELGR 813
              A   R
Sbjct: 935 CHPAAWSR 942


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  211 bits (537), Expect = 2e-54
 Identities = 219/780 (28%), Positives = 303/780 (38%), Gaps = 104/780 (13%)

Query: 9    KAGAAARTP--AARAPGLLTPRPPGSPRPPP----PVTPAALRVLGAAGAVGRKPLAERA 62
            K G A  +P  A   P +  P P GSP   P      TP A       G+    PL + A
Sbjct: 997  KGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGA 1056

Query: 63   GGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSS--PGRA 120
                 AT+P  +P+ GP   +   +  P +  P S +G  A P+   +P P ++  P   
Sbjct: 1057 PTTPAATLP--SPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPK 1114

Query: 121  SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 180
             G   P   G      +   +   G AT  PK +  +  A   +      TP P  A  +
Sbjct: 1115 GGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTT 1174

Query: 181  RAA---GTEVGLPRPAPSARPRPPTEGPRKSVSS-ASEHSTTEPSPAARRRPSAGGGLQR 236
             AA     + GL  P+P   P  P   P       A+      P+  A   PS  GGL  
Sbjct: 1175 PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLAT 1234

Query: 237  PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQV-----TPPRKD 291
            P+ +         ++PA + PS +G P  P     P P    A  PP +     TPP K 
Sbjct: 1235 PSPKGAP------TTPAATPPSPKGGPATPPPKGAPTP---PAATPPSLKGGLATPPHKG 1285

Query: 292  A---------APALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAP 342
            A         +P  GP +S P   P+P AA     PP+   +P          TP P   
Sbjct: 1286 APNPAVVTPPSPKGGPATSPPKGAPTPPAA----TPPSPKGSP---------GTPPPKGA 1332

Query: 343  PSPSA--PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLS-------PLATPP 393
            P+P A  PPS +  P+ PAT PS    S G PT  ++    P+PP +       P  TPP
Sbjct: 1333 PTPPAVTPPSPKGTPTLPATTPS----SKGGPTTPSSKEG-PTPPAATPSHKGGPAMTPP 1387

Query: 394  -PQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF 452
             P+  PA+  P  +  P+ PA  PLSP   P+       A    +   +PP   PV    
Sbjct: 1388 SPKRGPAIPSP--KGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKK 1445

Query: 453  SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATP--PPQAPPPLAAPPL 510
            +P  S P    ATP S+  P+L A     P  PPA   ++ S++P   P  P P+ AP L
Sbjct: 1446 APATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTL 1505

Query: 511  QLAKP--PPQAPPALATPPLQALP-SPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLA 567
                P  P + P   ATP  +  P +P A+   +   +P+   P   L  P    P    
Sbjct: 1506 PAVIPSSPKEVP---ATPSSRRDPIAPTATLLSKK--TPATLAPKEALIPPAMTVPSPKK 1560

Query: 568  APLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLAL------APGP---PPPPSRS 618
             P +  P   PA+P+ +    PP   P T    P     L      +P P   P PP+ +
Sbjct: 1561 TPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVT 1620

Query: 619  PSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAP- 677
            P S   GP       + TS P         P   A+ +     ++ A  P A    PA  
Sbjct: 1621 PPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVT----CKMGATVPQASKGLPAKK 1676

Query: 678  -PLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPE----SATPAPGALDPGPSPGTSG 732
             P A +    AP P         +  + T    +GP+    SAT  P   DP    G+ G
Sbjct: 1677 GPTALKEVLVAPAP--------ESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKG 1728



 Score =  207 bits (528), Expect = 3e-53
 Identities = 230/788 (29%), Positives = 303/788 (38%), Gaps = 101/788 (12%)

Query: 26   TPRPPGSPRPPPPV---TPAALRVLGAAGAVGRKPLAERAGGIGGATIPES-----APRA 77
            +P    SP PP P    TP+A+  L   G V   P       +     P+      AP+ 
Sbjct: 849  SPATTHSPTPPSPKGAPTPSAVTPLSPKG-VTLPPKETPTPSVVNLPFPKEGPATPAPKQ 907

Query: 78   GPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSS--PGRASGTTRPGPLGQKGLR 135
             P  S  +SS   A   PA  +G  A P+   +P P ++  P    G   P P       
Sbjct: 908  APALSMTSSSPKKARATPAP-KGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPP 966

Query: 136  ISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAA------GTEVGL 189
             +   +   G AT +PK +     A   +    P TPSP  A    A       G+    
Sbjct: 967  AATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAAT 1026

Query: 190  PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 249
            P P  ++ P   T    K   +A+      P+  A   PS  GG   PA+ SL  + TP 
Sbjct: 1027 PFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGG---PATPSLKGAPTP- 1082

Query: 250  SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP---LSSSPLAT 306
              PA + PS +G P  P+      PKG  A  PP  TPP      A  P     ++P AT
Sbjct: 1083 --PAATPPSPKGGPATPS------PKG--APMPPAATPPSPKGGLATPPHKGAPTTPAAT 1132

Query: 307  P-SPSAALQSQAPPTLPATPHSSSLTCQ--LATPLP--------LAPPSPS---APPSLQ 352
            P SP   L +  P   P TP ++  + +  LATP P          PPSP    A PS +
Sbjct: 1133 PPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPK 1192

Query: 353  TLPSPPATPPSQATTSLGSPTLQA---THSFLPSPPLSPLATPPPQAPPALALPPLQAPP 409
              P+ PA  P      L +P+ +    T +  P  P   LATP P+  P     P   PP
Sbjct: 1193 GAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPT---TPAATPP 1249

Query: 410  SP---PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSP---S 463
            SP   PA+PP     TP    P +L   L   P    P+P V  P SP   P  SP   +
Sbjct: 1250 SPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGA 1309

Query: 464  ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP-PLAAPPLQLAKPPPQAPPA 522
             TPP+  PPS        P   P +PP   + TPP   PP P   P L    P  +  P 
Sbjct: 1310 PTPPAATPPS--------PKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGP- 1360

Query: 523  LATPPLQALPSPPASFP----GQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPP 578
              TP  +  P+PPA+ P    G A   PS   P    A P P+  P   A +   P   P
Sbjct: 1361 -TTPSSKEGPTPPAATPSHKGGPAMTPPS---PKRGPAIPSPKGDPTSPAVIPLSPKKAP 1416

Query: 579  ASPTLQAPRRPPTPGPDTSVSGPRLTLALAP------GPPPPPSRSPSSTLSGPDLAGHS 632
            A+P  +     P+ G  T  +   ++L  AP      G P  PS     TL  P +   S
Sbjct: 1417 ATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTL--PAVTPPS 1474

Query: 633  SSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRG--APGAPL- 689
                  P+++    S  +  A  +P     L A  P++    PA P + R   AP A L 
Sbjct: 1475 PKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLL 1534

Query: 690  --PWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSR- 746
                P    P  A     I       S    P    P  +P T   K A+   A   S  
Sbjct: 1535 SKKTPATLAPKEA----LIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTY 1590

Query: 747  ----SPKQ 750
                SPK+
Sbjct: 1591 KGAPSPKE 1598



 Score =  203 bits (516), Expect = 6e-52
 Identities = 222/731 (30%), Positives = 292/731 (39%), Gaps = 173/731 (23%)

Query: 9    KAGAAARTPAARAPGLLTPRPPGSPRPPPP---VTPAALRVLGAAGAVGRKPLAERAGGI 65
            +A A + T ++      TP P G P  P P    TP A                      
Sbjct: 907  QAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPA---------------------- 944

Query: 66   GGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTR 125
              AT P  +P+ GP   +   +  P +  P S +G  A P+   +P P ++       T 
Sbjct: 945  --ATPP--SPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAA-------TP 993

Query: 126  PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT 185
            P P G              G AT +PK              PTP   +P   + S AA  
Sbjct: 994  PSPKG--------------GPATPSPK------------GAPTPPAVTPPSPKGSPAA-- 1025

Query: 186  EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSS 245
                P P  ++ P   T    K   +A+      P+  A   PS  GG   PA+ SL  +
Sbjct: 1026 ---TPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGG---PATPSLKGA 1079

Query: 246  ATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP---LSSS 302
             TP   PA + PS +G       P+ P PKG  A  PP  TPP      A  P     ++
Sbjct: 1080 PTP---PAATPPSPKG------GPATPSPKG--APMPPAATPPSPKGGLATPPHKGAPTT 1128

Query: 303  PLAT-PSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSP----SAPPSLQTLPSP 357
            P AT PSP   L +  P   P TP ++             PPSP    + PP      +P
Sbjct: 1129 PAATPPSPKGGLATPPPKGAPTTPAAT-------------PPSPKGGLATPPPKGAPTTP 1175

Query: 358  PATPPSQ----ATTS-LGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPP 412
             ATPPS     AT S  G+PT   T +  P  P   LATP P+  P     P   PPSP 
Sbjct: 1176 AATPPSPKGGLATPSPKGAPT---TPAATPPSPKGGLATPSPKGAPT---TPAATPPSPK 1229

Query: 413  ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPP 472
                   LATPSP+           AP +P  +PP  +P   PA+PP   + TPP+  PP
Sbjct: 1230 GG-----LATPSPKG----------APTTPAATPP--SPKGGPATPPPKGAPTPPAATPP 1272

Query: 473  S----LAAPPLQVPPSP----PASPPMSPSATPPPQAP-PPLAAPPLQLAK---PPPQ-- 518
            S    LA PP +  P+P    P SP   P+ +PP  AP PP A PP        PPP+  
Sbjct: 1273 SLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGA 1332

Query: 519  -APPALATPPLQALPSPPASFPGQ--APFSPSASL-PMSPLATPPPQAPPVLAAPLLQVP 574
              PPA+  P  +  P+ PA+ P     P +PS+   P  P ATP  +  P +       P
Sbjct: 1333 PTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAM------TP 1386

Query: 575  PSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSS 634
            PSP   P + +P+  PT       S   + L+    P  P +R  ++T S  DL    + 
Sbjct: 1387 PSPKRGPAIPSPKGDPT-------SPAVIPLSPKKAPATPVTREGAATPSKGDL----TP 1435

Query: 635  ATSTPEELR--GYDSGPEGG-AAASPPPDAELAACHPAAWSRGPAPPLAF-----RGAPG 686
               TP  L+     S P+GG A  S   D  L A  P +    PAP         + AP 
Sbjct: 1436 PAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPA 1495

Query: 687  APLPWPPATGP 697
             P P    T P
Sbjct: 1496 TPAPMGAPTLP 1506



 Score =  200 bits (508), Expect = 5e-51
 Identities = 200/699 (28%), Positives = 269/699 (38%), Gaps = 76/699 (10%)

Query: 13   AARTPAARAP----GLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRK--PLAERAGGIG 66
            A  TPAA  P    GL TP P G+P  P    P+    L      G    P A      G
Sbjct: 1171 APTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKG 1230

Query: 67   GATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSP-GRASGTTR 125
            G   P  +P+  PT         PA+ PP+   G   PP K     P ++P     G   
Sbjct: 1231 GLATP--SPKGAPT--------TPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLAT 1280

Query: 126  PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT 185
            P   G     +    +   G AT  PK +     A   +   +PGTP P      + A T
Sbjct: 1281 PPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPP------KGAPT 1334

Query: 186  EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSS 245
               +  P+P   P  P   P       +  S   P+P A      GG    P S      
Sbjct: 1335 PPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPS------ 1388

Query: 246  ATPLSSPARSGPSARGTPRAPAH-PSQPKPKGLQALRPPQVTPPRKDAA-PALGPLSSSP 303
              P   PA   PS +G P +PA  P  PK       + P     R+ AA P+ G L+   
Sbjct: 1389 --PKRGPAI--PSPKGDPTSPAVIPLSPK-------KAPATPVTREGAATPSKGDLTPPA 1437

Query: 304  LATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPS 363
            +   S   A  + AP   PATP SS     L    P +P  P AP  + T  SP   P +
Sbjct: 1438 VTPVSLKKAPATSAPKGGPATP-SSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPAT 1496

Query: 364  QATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATP 423
             A   +G+PTL A    +PS P    ATP  +  P      L +  +P    P   L  P
Sbjct: 1497 PAP--MGAPTLPAV---IPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPP 1551

Query: 424  SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP 483
            +   P+      +  P   P +P  +   SPPA   V+PS    + +P  L  PP    P
Sbjct: 1552 AMTVPSPKKTPAIPTPKEAPATPSSKEASSPPA---VTPSTYKGAPSPKELLIPPAVTSP 1608

Query: 484  SPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPAL---ATPPLQALPSPPASFPG 540
            SP  + P  P+ TPP     P    P      PP  P +L    T P        A+ P 
Sbjct: 1609 SPKEA-PTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQ 1667

Query: 541  QAPFSPSASLPMS---PLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTS 597
             +   P+   P +    L  P P++ P++ AP  + P +  +S T  +P   P P     
Sbjct: 1668 ASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSAT--SPPICPDPSAKNG 1725

Query: 598  VSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAA--- 654
              GP  T  +AP P  P  +  S T  G D A HS      P E +   S P   AA   
Sbjct: 1726 SKGPLST--VAPAPLLPVQKDSSKTAKGKD-ASHSPKGPLAPPESKA--STPLTAAAFEK 1780

Query: 655  ASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPP 693
              P P++       A+ S  P+PP++   AP +P+P  P
Sbjct: 1781 VLPKPES-------ASVSAAPSPPVSLPLAP-SPVPTLP 1811



 Score =  147 bits (370), Expect = 5e-35
 Identities = 178/626 (28%), Positives = 239/626 (38%), Gaps = 98/626 (15%)

Query: 7    KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVG--RKPLAERAGG 64
            K     A  TP +   G  T  P G+P PP    P+     G     G    P       
Sbjct: 1284 KGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSP 1343

Query: 65   IGGATIPESAP-----------RAGPTRSAGTSSR--NPASRPPASGRGERAPPAKN--T 109
             G  T+P + P           + GPT  A T S    PA  PP+  RG   P  K   T
Sbjct: 1344 KGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPT 1403

Query: 110  SPGPVS-SPGRASGT--TRPGPL----GQKGLRISAEETVARGKATEAPKRSALSAGARR 162
            SP  +  SP +A  T  TR G      G          ++ +  AT APK    +  ++ 
Sbjct: 1404 SPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKG 1463

Query: 163  DTSGP--TPGTPS--PAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTT 218
            D + P  TP +P   PA  + + ++  +     PAP   P  P   P    SS  E   T
Sbjct: 1464 DPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIP----SSPKEVPAT 1519

Query: 219  EPSPAARRRPSAGGGLQRPASRSLSSSATP--------LSSPARSGPSARGTPRAPAHPS 270
               P++RR P A        + +L S  TP        L  PA + PS + TP  P    
Sbjct: 1520 ---PSSRRDPIA-------PTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKE 1569

Query: 271  QP-KPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSS 329
             P  P   +A  PP VTP     AP+   L   P  T SPS       P   P +P    
Sbjct: 1570 APATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVT-SPSPKEAPTPPAVTPPSPEKGP 1628

Query: 330  LTCQLATPLPLAPPS--PSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFL----PS 383
                 ATP P   P+  P  P SL+  P    T P+  T  +G+   QA+        P+
Sbjct: 1629 -----ATPAPKGTPTSPPVTPSSLKDSP----TSPASVTCKMGATVPQASKGLPAKKGPT 1679

Query: 384  PPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 443
                 L  P P++ P +  P  + P +  +S   SP   P P A N     L  +  +P 
Sbjct: 1680 ALKEVLVAPAPESTPIITAPTRKGPQTKKSS-ATSPPICPDPSAKNGSKGPL--STVAPA 1736

Query: 444  PSPPVQ-----------APFSP--PASPPVSPSATPPSQAP-----PSLAAPPLQVPPSP 485
            P  PVQ           A  SP  P +PP S ++TP + A      P   +  +   PSP
Sbjct: 1737 PLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSP 1796

Query: 486  PASPPMSPSATP--PPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAP 543
            P S P++PS  P  PP+     ++P L L  P     PA     L  +P  P S  G  P
Sbjct: 1797 PVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPIS--GGVP 1854

Query: 544  FS------PSASLPMSPLATPPPQAP 563
            F       P+      P+ TP  + P
Sbjct: 1855 FQSVLVNMPTPKSAGIPVPTPSAKQP 1880



 Score =  143 bits (361), Expect = 6e-34
 Identities = 210/781 (26%), Positives = 284/781 (36%), Gaps = 101/781 (12%)

Query: 16   TPAARAPGLLTPRPPGS--------PRPPPPVTPAALRVLGAAGAVG---RKPLAERAGG 64
            +PAA     + P+ P +        P  PP   P  L+ L ++  V    +K L      
Sbjct: 479  SPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPAS 538

Query: 65   IGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTT 124
            + GA          P ++  T+ ++P   P      + +P  ++TS  P   P     T 
Sbjct: 539  LEGAPF-------SPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSP-EIPLSPEATL 590

Query: 125  RPGPLGQKGLRISAEETVARGKATEA---PKRSALSAGARRDTSGPTPGTPSPAMARRSR 181
                LG         E +  GK   +   P     SA   +  S   P +  P + + S 
Sbjct: 591  AKKSLG---------EPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLL-KSSL 640

Query: 182  AAGTEVGLPRPAPSARPRPPT--EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQR-PA 238
               T    P  +       PT  +G     ++AS       S A +  P   G L   P 
Sbjct: 641  ITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPL 700

Query: 239  SRSLSSSATPLSSPARSGPSARGTPRAPAHP-SQPKPKGLQALRPPQVTPPRKDAAP--- 294
              + S +     SP  +         AP  P S P P       PP  TPP         
Sbjct: 701  VPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPS-----LPPAGTPPGTKKVDGIS 755

Query: 295  ---ALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLA---PPSPSAP 348
               AL P++SSP   P+  +   + A           +LT    +P PL     P    P
Sbjct: 756  HTSALAPVASSPKECPTEDSGASATASS-------KGTLTYLADSPSPLGVSVSPQTKRP 808

Query: 349  PSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPL-QA 407
            P+ +    P  TP      +L SP      SFLP   LS   +    A      PP  + 
Sbjct: 809  PTKKGSAGPD-TPIG----NLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKG 863

Query: 408  PPSPPASPPLSP--LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT 465
             P+P A  PLSP  +  P  + P    V+L   PF      P + P +P  +P  +P+ +
Sbjct: 864  APTPSAVTPLSPKGVTLPPKETPTPSVVNL---PF------PKEGPATP--APKQAPALS 912

Query: 466  PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT 525
              S +P    A P   P   PASP  SP   P P    P A PP     P   +P    T
Sbjct: 913  MTSSSPKKARATP--APKGIPASP--SPKGAPTP----PAATPPSPKGGPATPSPKWAPT 964

Query: 526  PPLQALPSP---PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPT 582
            PP    PSP   PA+   +   +P A+ P SP   P   +P     P    PPSP  SP 
Sbjct: 965  PPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPA 1024

Query: 583  LQA-PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEE 641
                P+   TP P  +   P+ + A  P P   P+ +P++TL  P     + S    P  
Sbjct: 1025 ATPFPKGASTP-PAATPPSPKGSPAATPLPKGAPT-TPAATLPSPKGGPATPSLKGAPTP 1082

Query: 642  LRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSAD 701
                   P+GG A   P  A +    PAA    P   LA     GAP   P AT P    
Sbjct: 1083 PAATPPSPKGGPATPSPKGAPMP---PAATPPSPKGGLATPPHKGAPTT-PAATPPSPKG 1138

Query: 702  GLCTIYETEGPESATPAPGALDPGPSPG--TSGGKAAAGAGAGASSRSPKQARLGELPLG 759
            GL     T  P+ A   P A  P P  G  T   K A    A A+  SPK       P G
Sbjct: 1139 GLA----TPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPA-ATPPSPKGGLATPSPKG 1193

Query: 760  A 760
            A
Sbjct: 1194 A 1194



 Score =  114 bits (285), Expect = 4e-25
 Identities = 224/902 (24%), Positives = 317/902 (35%), Gaps = 176/902 (19%)

Query: 10   AGAAARTPAARAPGLLTPRPPGSPRPP--------PPVTPAALRVLGAAGAVGRKP---L 58
            A +  +T   + P  + P P G+P PP          VTP A    G A      P   L
Sbjct: 180  APSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTL 239

Query: 59   AERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPA---------------SGRGERA 103
            A  +  +   TI  S+    P      S + P S P A                  G   
Sbjct: 240  AIASPQVKDTTI--SSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNT 297

Query: 104  PPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETV-------ARGKATEAPKRSAL 156
            PP    S G   +P   S       LGQ G    ++ TV       +   A+   +RS +
Sbjct: 298  PPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVI 357

Query: 157  SAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE---GPRKSVSSAS 213
                 R+   P      P +A       + +     +PS      T     P  S+   S
Sbjct: 358  PPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKS 417

Query: 214  EHSTTEPSPAARRRPSAGGG-----LQRPASRSLSSS-----ATPLSSPARSGPSARGTP 263
              + T   P   + P +  G     +  P + + + +     AT +S P  SGP +   P
Sbjct: 418  SPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEP 477

Query: 264  RAPA-------HPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQ 316
             +PA        P +P  +    LR P V+PP  D    L  L SS L        LQ+ 
Sbjct: 478  TSPAALVMAPVAPKEPSTQVATTLRIP-VSPPLPDPED-LKNLPSSVLVKFPTQKDLQT- 534

Query: 317  APPTL---PATPHSSSLTCQL-ATPLPLAPPSPSAPPSLQTLPSPPATPPSQATT----S 368
             P +L   P +P  + LT +   T LPL   +P   PS Q+  S P  P S   T    S
Sbjct: 535  VPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKS 594

Query: 369  LGSP-TLQATHSFLPSP----------------------PL--SPLATPPPQAPPALALP 403
            LG P  +    S + SP                      PL  S L TP   A P  +  
Sbjct: 595  LGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESAD 654

Query: 404  PLQAPP---------SPPASP-----------------------PLSPLAT------PSP 425
            P    P         +  ASP                       PL P A+      PSP
Sbjct: 655  PAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSP 714

Query: 426  QAPNALAVHLLQAPFSPP--PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP 483
            Q   A    L+ AP  P   PSP +    +PP +  V   +   + AP  +A+ P + P 
Sbjct: 715  QNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAP--VASSPKECPT 772

Query: 484  SPPASPPMSPSA--------TPPP---QAPPPLAAPPLQLAKPPPQAPPA-LATP--PLQ 529
                +   + S         +P P      P    PP +     P  P   L++P  P++
Sbjct: 773  EDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVE 832

Query: 530  A--LPSPPASFPG--QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPT--- 582
            A  LP    SF G   +P +  +  P SP   P P A   L+   + +PP    +P+   
Sbjct: 833  ASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVN 892

Query: 583  LQAPRR-PPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEE 641
            L  P+  P TP P      P L++  +       + +P    + P   G  +   +TP  
Sbjct: 893  LPFPKEGPATPAPK---QAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPS 949

Query: 642  LRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSAD 701
             +G  + P    A +PP      A  P +   GPA P + +GAP  P   PP+   G A 
Sbjct: 950  PKGGPATPSPKWAPTPP------AATPPSPKGGPATP-SPKGAPTPPAATPPSPKGGPA- 1001

Query: 702  GLCTIYETEGPESATPAPGALDPGP--SPGTSGGKAAAGAGAGASSRSPKQARLG-ELPL 758
                   T  P+ A   P    P P  SP  +     A     A+  SPK +     LP 
Sbjct: 1002 -------TPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPK 1054

Query: 759  GA 760
            GA
Sbjct: 1055 GA 1056



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 159/643 (24%), Positives = 240/643 (37%), Gaps = 111/643 (17%)

Query: 151 PKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVS 210
           P  SALS  A     GPT   P     ++   +      P P+PS     P E P    S
Sbjct: 27  PMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSS 86

Query: 211 SASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPS 270
           S     T  P   A   P+    L  P    +S +A  L+SP    P+ +GTP + A   
Sbjct: 87  S----GTALPLGTAPEAPTFLPNLIGP---PISPAALALASP-MIAPTLKGTPSSSA--- 135

Query: 271 QPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSL 330
              P  L AL P  V   +K +A     L+S P    + S ++ + + P  P+ P  ++L
Sbjct: 136 ---PLALVALAPHSV---QKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEP-KTNL 188

Query: 331 TCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGS--PTLQATHSFLPSPPLSP 388
               +  +P    +PS P  + T+P    TP +   + + S   T   T   + SP +  
Sbjct: 189 NKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKD 248

Query: 389 LATP----PPQAPPALALPPLQAPPSPPASPPLS----PLATPS---------PQAPNAL 431
                    PQ P +L+   L+ P SPPA+  LS    P+ T S         P  P +L
Sbjct: 249 TTISSVLISPQNPGSLS---LKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISL 305

Query: 432 AVHLL---QAPF--------------SPPPSPPVQAPFSPP-ASPPVSPSATPP-----S 468
             HL    Q+ F              S P    +    S   AS P   S  PP      
Sbjct: 306 GSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNE 365

Query: 469 QAPPSLAAPPLQVP-----PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAP--- 520
             P ++AA P+  P     PS  +S   SPS +        L+     + K  P A    
Sbjct: 366 VVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHY 425

Query: 521 PALATPPLQALPSPP--ASFPGQAPFSPSASLPMSPLATPPPQAPPV-----------LA 567
           P +A  P+ ++ + P   + P     +P+ +  ++   +PP  + P+           + 
Sbjct: 426 PLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVM 485

Query: 568 APLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP-------------GPPPP 614
           AP+    PS   + TL+ P  PP P P+   + P   L   P             G P  
Sbjct: 486 APVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFS 545

Query: 615 PSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRG 674
           P+++  +T   P +     +A       +   S PE        P+A L     A  S G
Sbjct: 546 PAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPE----IPLSPEATL-----AKKSLG 596

Query: 675 PAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATP 717
              P+   G P + +  P   G  S+  +       GP+SA P
Sbjct: 597 EPLPI---GKPASSMTSP--LGVNSSASVIKTDSYAGPDSAGP 634



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 103/370 (27%), Positives = 145/370 (39%), Gaps = 47/370 (12%)

Query: 346 SAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPL 405
           + P + Q LP P A       +S  S T        P P L P  +P PQ  P  A    
Sbjct: 8   TVPATEQELPQPQAETAVLPMSSALSVTAALGQ---PGPTLPPPCSPAPQQCPLSAAN-- 62

Query: 406 QAPPSP-PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP-VQAPFSPPASPPVSPS 463
           QA P P P++   +PL  P PQ+ +  A+ L  AP +P   P  +  P SP A    SP 
Sbjct: 63  QASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPM 122

Query: 464 ATPPSQAPPSLAAPPLQV---PPSPPASPPMSPS-ATPPPQAPPPLAAPPLQLAKP-PPQ 518
             P  +  PS +AP   V   P S   S    P+  T PP      +   + L+ P  P 
Sbjct: 123 IAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPS 182

Query: 519 AP-------PALATPPLQALPSPPASFPGQAPF---SPSASL-----------PMSPLAT 557
            P       P+   P  +  PSPP       P+   +P AS+           P + LA 
Sbjct: 183 EPKTNLNKVPSEVVPNPKGTPSPPC-IVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAI 241

Query: 558 PPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR 617
             PQ      + +L + P  P S +L+ P  PP     ++ S P +T +     P  P  
Sbjct: 242 ASPQVKDTTISSVL-ISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPD 300

Query: 618 SPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPA- 676
            P S   G  LA    S+  + + L     G  G +A S P    ++  H +  +  P+ 
Sbjct: 301 FPISL--GSHLAPLHQSSFGSVQLL-----GQTGPSALSDPTVKTISVDHSSTGASYPSQ 353

Query: 677 ----PPLAFR 682
               PPL  R
Sbjct: 354 RSVIPPLPSR 363



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 134/530 (25%), Positives = 198/530 (37%), Gaps = 77/530 (14%)

Query: 185 TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEP--SPAARRRPSAGGGLQRPASRSL 242
           TE  LP+P       P +     + +      T  P  SPA ++ P +      P     
Sbjct: 12  TEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPS 71

Query: 243 SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 302
           + ++TPL  P     S    P   A P  P         P  + PP          +S +
Sbjct: 72  TIASTPLEVPFPQSSSGTALPLGTA-PEAP------TFLPNLIGPP----------ISPA 114

Query: 303 PLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPP 362
            LA  SP  A      PTL  TP SS+    +A        S + PP+L T P   A   
Sbjct: 115 ALALASPMIA------PTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAE 168

Query: 363 SQATTSLGSPTL----QATHSFLPSPPL-SPLATPPP----QAPPALALPPL----QAPP 409
           S +  +L +P      +   + +PS  + +P  TP P       P   + P+        
Sbjct: 169 SGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVA 228

Query: 410 SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQ 469
           S P + P + LA  SPQ  +     +L +P   P S  ++ P SPPA+  +S  + P   
Sbjct: 229 SLPQTTPTTTLAIASPQVKDTTISSVLISP-QNPGSLSLKGPVSPPAALSLSTQSLPVVT 287

Query: 470 APPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQ 529
           +    A P    PP  P S  +     P  Q+    +   +QL       P AL+ P ++
Sbjct: 288 SSQKTAGP--NTPPDFPIS--LGSHLAPLHQS----SFGSVQLL--GQTGPSALSDPTVK 337

Query: 530 AL----PSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585
            +     S  AS+P Q    P   LP      P   A   + AP +   PS  +S T   
Sbjct: 338 TISVDHSSTGASYPSQRSVIP--PLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITC-- 393

Query: 586 PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHS-SSATSTPEELRG 644
                +P    +V+    + +L+P        SP++T   P +A    SS  +TP  +  
Sbjct: 394 -----SPSGSLNVA---TSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTN 445

Query: 645 YDSGPEGGAAASPPPDAELAACHPAAWSRG------PAPPLAFRGAPGAP 688
             +      AA+P    E+A C     S G      P  P A   AP AP
Sbjct: 446 PCT-----IAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAP 490


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score =  165 bits (417), Expect = 2e-40
 Identities = 146/507 (28%), Positives = 187/507 (36%), Gaps = 68/507 (13%)

Query: 272  PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLT 331
            P  K +    PP  TP    + P     +  P  TPSP     +  PPT   +P  ++ T
Sbjct: 1391 PMDKCITTPSPPTTTP----SPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTT 1446

Query: 332  CQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH---SFLPSPPLSP 388
                T  P  P S +  P   T PSPP T PS  TT+   PT   T    +  PSPP + 
Sbjct: 1447 TPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTT 1506

Query: 389  LATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPV 448
              TPP        LPP   P SPP +   +P                   P +  PSPP 
Sbjct: 1507 PITPPASTT---TLPPTTTP-SPPTTTTTTP-------------------PPTTTPSPPT 1543

Query: 449  QAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA----SPPMSPSATPPPQAPPP 504
              P +PP S    P  T PS  P +   PP    PSPP     SPP   + TPPP   P 
Sbjct: 1544 TTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTP- 1602

Query: 505  LAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPP 564
              +PP      PP  P    +PP     +PP S     P + + S P +   TPPP   P
Sbjct: 1603 --SPPTTTTTTPP--PTTTPSPPTTTPITPPTSTTTLPP-TTTPSPPPTTTTTPPPTTTP 1657

Query: 565  VLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLS 624
               +P     PSPP + T   P       P T+   P  T    P P   PS SP +T +
Sbjct: 1658 ---SPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPS-SPITTTT 1713

Query: 625  GPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGA 684
             P       S+T+TP       + P      SPP                   P     +
Sbjct: 1714 TP-------SSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTL------------PPTTTSS 1754

Query: 685  PGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGP----SPGTSGGKAAAGAG 740
            P    P PP+  P +     T   T          G LD G      PG          G
Sbjct: 1755 PLTTTPLPPSITPPTFSPFSTTTPTTPCVPLCNWTGWLDSGKPNFHKPGGDTELIGDVCG 1814

Query: 741  AG-ASSRSPKQARLGELPLGALQASVV 766
             G A++ S +     ++P+G L  +VV
Sbjct: 1815 PGWAANISCRATMYPDVPIGQLGQTVV 1841



 Score =  163 bits (413), Expect = 6e-40
 Identities = 128/408 (31%), Positives = 164/408 (40%), Gaps = 54/408 (13%)

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTL 321
            TP  P     P P     L PP  TP    + P     +  P  TPSP     +  PPT 
Sbjct: 1398 TPSPPTTTPSPPPTSTTTL-PPTTTP----SPPTTTTTTPPPTTTPSPPITTTTTPPPTT 1452

Query: 322  PATPHSSSLTCQLATPLPLAP---PSPS----APPSLQTLPSPPATPPSQATTSLGSPTL 374
              +P  S+ T    T  P  P   PSP     +PP+  T   PP T PS  TT+  +P  
Sbjct: 1453 TPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPA 1512

Query: 375  QAT---HSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPAS-PPLSPLATPSPQAPNA 430
              T    +  PSPP +   TPPP   P+   PP   P +PP S   L P  TPSP     
Sbjct: 1513 STTTLPPTTTPSPPTTTTTTPPPTTTPS---PPTTTPITPPTSTTTLPPTTTPSPPPTTT 1569

Query: 431  LAVHLLQAPFSPP----PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPP 486
                    P SPP    PSPP     +PP +   SP  T  +  PP+    P   P + P
Sbjct: 1570 TTPPPTTTP-SPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSP---PTTTP 1625

Query: 487  ASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSP 546
             +PP S +  PP   P P   PP     PPP   P   +PP    PSPP +        P
Sbjct: 1626 ITPPTSTTTLPPTTTPSP---PPTTTTTPPPTTTP---SPPTTTTPSPPIT---TTTTPP 1676

Query: 547  SASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPT-----LQAPRRPP----TPGPDTS 597
              + P SP+ T P      +  P     PS P + T        P  PP    TP P T+
Sbjct: 1677 PTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTT 1736

Query: 598  VSGPRLTLALAPGPPPPPSRSPSST------LSGPDLAGHSSSATSTP 639
             S P  T+      PP  + SP +T      ++ P  +  S++  +TP
Sbjct: 1737 PSPPTTTMTTL---PPTTTSSPLTTTPLPPSITPPTFSPFSTTTPTTP 1781



 Score =  162 bits (410), Expect = 1e-39
 Identities = 134/468 (28%), Positives = 180/468 (38%), Gaps = 70/468 (14%)

Query: 148  TEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRK 207
            T +P  +  S      T+ P   TPSP     +           P P+  P PP      
Sbjct: 1398 TPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTT----------TPPPTTTPSPPI----- 1442

Query: 208  SVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPA 267
              ++ +   TT PSP              P S + +   T   SP  + PS   T  +P 
Sbjct: 1443 -TTTTTPPPTTTPSP--------------PISTTTTPPPTTTPSPPTTTPSPPTTTPSPP 1487

Query: 268  HPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS---PLATPSPSAALQSQAPP-TLPA 323
              +   P       PP  TP      P   P S++   P  TPSP     +  PP T P+
Sbjct: 1488 TTTTTTP-------PPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPS 1540

Query: 324  TPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQAT---HSF 380
             P ++ +T   +T       +PS PP+  T P P  TP    TT+   PT+  T    + 
Sbjct: 1541 PPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTT 1600

Query: 381  LPSPPLSPLATPPPQAPPALALPPLQAPPSPPAS-PPLSPLATPSPQAPNALAVHLLQAP 439
             PSPP +   TPPP   P+   PP   P +PP S   L P  TPSP              
Sbjct: 1601 TPSPPTTTTTTPPPTTTPS---PPTTTPITPPTSTTTLPPTTTPSPPPTTTT-------- 1649

Query: 440  FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP 499
             +PPP+     P +   SPP++ + TPP    PS    P+   PSPP +   +PS T  P
Sbjct: 1650 -TPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPS---SPITTTPSPPTTTMTTPSPTTTP 1705

Query: 500  QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPP----ASFPGQAPFSPSASLPMSPL 555
             +P      P     P P  P  + TP     PSPP     + P     SP  + P+ P 
Sbjct: 1706 SSPITTTTTPSSTTTPSP-PPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPS 1764

Query: 556  ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPT---PGPDTSVSG 600
             TPP  +P     P    P  P  + T       P    PG DT + G
Sbjct: 1765 ITPPTFSPFSTTTP--TTPCVPLCNWTGWLDSGKPNFHKPGGDTELIG 1810



 Score =  153 bits (387), Expect = 6e-37
 Identities = 128/434 (29%), Positives = 166/434 (38%), Gaps = 66/434 (15%)

Query: 198  PRPPTEGPRKSVSSASE-HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG 256
            P PPT  P    +S +    TT PSP                    +++ TP  +   S 
Sbjct: 1399 PSPPTTTPSPPPTSTTTLPPTTTPSPPT------------------TTTTTPPPTTTPSP 1440

Query: 257  PSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQ 316
            P    T   P     P P       PP  TP      P      S P  TPSP     + 
Sbjct: 1441 PITTTTTPPPTTTPSP-PISTTTTPPPTTTPSPPTTTP------SPPTTTPSPPTTTTTT 1493

Query: 317  APPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQA 376
             PPT   +P +++     A+   L P +  +PP+  T   PP T PS  TT+  +P    
Sbjct: 1494 PPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTST 1553

Query: 377  TH---SFLPSPP-LSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALA 432
            T    +  PSPP  +   TPPP   P+   PP    PSPP     +P  T +P  P    
Sbjct: 1554 TTLPPTTTPSPPPTTT-TTPPPTTTPS---PPTTTTPSPPTITTTTPPPTTTPSPPTTTT 1609

Query: 433  VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA----S 488
                  P +  PSPP   P +PP S    P  T PS  P +   PP    PSPP     S
Sbjct: 1610 T---TPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPS 1666

Query: 489  PPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSA 548
            PP++ + TPPP   P   + P+     PP     + TP     PS P +         + 
Sbjct: 1667 PPITTTTTPPPTTTP---SSPITTTPSPPTT--TMTTPSPTTTPSSPIT---------TT 1712

Query: 549  SLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALA 608
            + P S     PP  P  +  P     PSPP +          T  P T+ S P  T  L 
Sbjct: 1713 TTPSSTTTPSPP--PTTMTTPSPTTTPSPPTTTM--------TTLPPTTTSSPLTTTPLP 1762

Query: 609  PGPPPPPSRSPSST 622
            P    PP+ SP ST
Sbjct: 1763 PS-ITPPTFSPFST 1775



 Score =  138 bits (348), Expect = 2e-32
 Identities = 126/483 (26%), Positives = 172/483 (35%), Gaps = 101/483 (20%)

Query: 24   LLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSA 83
            + TP PP +   PPP +                            T+P +   + PT + 
Sbjct: 1396 ITTPSPPTTTPSPPPTSTT--------------------------TLPPTTTPSPPTTTT 1429

Query: 84   GTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVA 143
             T        PP +      PP   T   P+S+      TT P P               
Sbjct: 1430 TTPPPTTTPSPPITTT--TTPPPTTTPSPPISTTTTPPPTTTPSP--------------- 1472

Query: 144  RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 203
                T +P  +  S      T+ P   TPSP          +   LP   P+  P PPT 
Sbjct: 1473 -PTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLP---PTTTPSPPTT 1528

Query: 204  GPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS-RSLSSSATPLSSPARSGPSARGT 262
                        +TT P P     P     +  P S  +L  + TP   P  +      T
Sbjct: 1529 ------------TTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTT 1576

Query: 263  PRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLP 322
              +P   + P P  +    PP  T P   + P     +  P  TPSP        P T P
Sbjct: 1577 TPSPPTTTTPSPPTITTTTPPPTTTP---SPPTTTTTTPPPTTTPSP--------PTTTP 1625

Query: 323  ATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLP 382
             TP +S+ T    T       +PS PP+  T P PP T PS  TT+             P
Sbjct: 1626 ITPPTSTTTLPPTT-------TPSPPPTTTTTP-PPTTTPSPPTTT------------TP 1665

Query: 383  SPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS- 441
            SPP++   TPPP   P+    P+   PSPP +   +P  T +P +P    +     P S 
Sbjct: 1666 SPPITTTTTPPPTTTPS---SPITTTPSPPTTTMTTPSPTTTPSSP----ITTTTTPSST 1718

Query: 442  PPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA--SPPMSPSATPPP 499
              PSPP     +P  +   SP  T  +  PP+  + PL   P PP+   P  SP +T  P
Sbjct: 1719 TTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTP 1778

Query: 500  QAP 502
              P
Sbjct: 1779 TTP 1781



 Score =  113 bits (282), Expect = 9e-25
 Identities = 154/754 (20%), Positives = 245/754 (32%), Gaps = 84/754 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3609 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3661

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3662 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3721

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3722 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3775

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3776 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3832

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3833 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3889

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3890 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3944

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3945 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 4001

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 4002 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 4060

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 4061 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 4120

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSPPAS------PTLQ 584
            P  +  P   P + + ++  +P    T  P   P+     +   P+P  +      P   
Sbjct: 4121 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 4180

Query: 585  APRRPPTPGPDTSVSGPRLTLALAP------GPPPPPSRSPSSTLSGPDLAGHSSSATST 638
                 PTP P  + +GP    + AP        PPP S +P ++ S       S++  ST
Sbjct: 4181 TTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLST 4240

Query: 639  PEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPG 698
                      P     ++ PP    A    +       PP      PG P      TG  
Sbjct: 4241 --------LPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTR-GTTTGSS 4291

Query: 699  SADGLCTIYETEGPESATPAPGALDPGPSPGTSG 732
            SA    T+ +T    + TP P  L       T+G
Sbjct: 4292 SAPTPSTV-QTTTTSAWTPTPTPLSTPSIIRTTG 4324



 Score =  105 bits (263), Expect = 1e-22
 Identities = 144/668 (21%), Positives = 217/668 (32%), Gaps = 139/668 (20%)

Query: 22   PGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTR 81
            P   TP PP +   PP  TP                               S P    T 
Sbjct: 1465 PPTTTPSPPTTTPSPPTTTP-------------------------------SPPTTTTTT 1493

Query: 82   SAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEET 141
               T++ +P +  P +      PPA  T+  P ++P   + TT   P        +    
Sbjct: 1494 PPPTTTPSPPTTTPIT------PPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPI 1547

Query: 142  VARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPP 201
                  T  P  +  S      T+ P   TPSP     +  +   +    P P+  P PP
Sbjct: 1548 TPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTT--TTPSPPTITTTTPPPTTTPSPP 1605

Query: 202  TEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS-RSLSSSATPLSSPARSGPSAR 260
            T             +TT P P     P     +  P S  +L  + TP   P  +     
Sbjct: 1606 TT------------TTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPP 1653

Query: 261  GTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPL-ATPS-PSAALQSQAP 318
             T  +P   + P P       PP  T P            SSP+  TPS P+  + + +P
Sbjct: 1654 TTTPSPPTTTTPSPPITTTTTPPPTTTP------------SSPITTTPSPPTTTMTTPSP 1701

Query: 319  PTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH 378
             T P++P +++ T       P +  +PS PP+  T PS P T PS  TT++ +     T 
Sbjct: 1702 TTTPSSPITTTTT-------PSSTTTPSPPPTTMTTPS-PTTTPSPPTTTMTTLPPTTTS 1753

Query: 379  SFLPSPPLSPLATPPPQAPPALALPPLQAPP----------------------------- 409
            S L + PL P  TPP  +P +   P     P                             
Sbjct: 1754 SPLTTTPLPPSITPPTFSPFSTTTPTTPCVPLCNWTGWLDSGKPNFHKPGGDTELIGDVC 1813

Query: 410  SPPASPPLSPLATPSPQAPNA---------LAVHLLQAPFSPPPSPPVQAPF-------- 452
             P  +  +S  AT  P  P           ++V L+       P   +   F        
Sbjct: 1814 GPGWAANISCRATMYPDVPIGQLGQTVVCDVSVGLICKNEDQKPGGVIPMAFCLNYEINV 1873

Query: 453  ---SPPASPPVSPSATPPSQAPPSLA--APPLQVPPSPPASPPMSPSATPPPQAPPPLAA 507
                    P    + T  +  PP+         V P+P  +   +P+ T P      +  
Sbjct: 1874 QCCECVTQPTTMTTTTTENPTPPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTVTP 1932

Query: 508  PPLQLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPF--------SPSASLPMSPLATP 558
             P       P   P   T  +   P+P  +  P   P         +P+ +   +P  TP
Sbjct: 1933 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 1992

Query: 559  PPQAPPVLAAPL---LQVPPSPPASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPP 614
                  V   P     Q P + P + T      P   G  T  + P   T  + P P P 
Sbjct: 1993 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2052

Query: 615  PSRSPSST 622
             +++P++T
Sbjct: 2053 GTQTPTTT 2060



 Score =  103 bits (256), Expect = 9e-22
 Identities = 129/651 (19%), Positives = 212/651 (32%), Gaps = 68/651 (10%)

Query: 16   TPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAP 75
            TP    P   T     +P P    TP    +          P     G     T P +  
Sbjct: 1894 TPPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT---PTPTPTGTQTPTTTPITTT 1950

Query: 76   RAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLR 135
                     T ++ P + P  +       P    +  P ++P   + T  P P       
Sbjct: 1951 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2010

Query: 136  ISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPS 195
             +          T  P  +          +  T  TP+P         GT+     P  +
Sbjct: 2011 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITT 2064

Query: 196  ARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARS 255
                 PT  P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +
Sbjct: 2065 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPT 2121

Query: 256  G---PSARGTPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLS 300
            G   P+             P P G Q    P  TP            P     P   P++
Sbjct: 2122 GTQTPTTTPITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2178

Query: 301  SSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT 360
            ++   TP+P+    +Q P T P T    + T    TP P    +P+  P   T    P  
Sbjct: 2179 TTTTVTPTPTPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2233

Query: 361  PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASP 415
             P+   T   +P +  T +  P+P  +P  T  P   P      +   P+P     P + 
Sbjct: 2234 TPTGTQTPTTTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2290

Query: 416  PLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSAT 465
            P++   T +P       Q P    +       +P P+P   Q P + P   +  V+P+ T
Sbjct: 2291 PITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2349

Query: 466  PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALA 524
            P     P+          +P  +P  + + T  P        P P       P   P   
Sbjct: 2350 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2409

Query: 525  TPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---- 577
            T  +   P+P  +  P   P + + ++  +P    T  P   P+     +   P+P    
Sbjct: 2410 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2469

Query: 578  -----PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
                 P + T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2470 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2520



 Score =  103 bits (256), Expect = 9e-22
 Identities = 155/796 (19%), Positives = 249/796 (31%), Gaps = 97/796 (12%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3471 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3523

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3524 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3583

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3584 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3637

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3638 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3694

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3695 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3751

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3752 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3806

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3807 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3863

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3864 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3922

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3923 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3982

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3983 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 4042

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST----------------LS 624
            T      P   G  T  + P   T  + P P P  +++P++T                  
Sbjct: 4043 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 4102

Query: 625  GPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGA 684
             P     +++ T TP         P G    +  P        P     G   P      
Sbjct: 4103 TPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 4156

Query: 685  PGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAA--AGAGAG 742
                +  P  T  G+     T   T    + TP P     GP   TS    A    +   
Sbjct: 4157 TTTTVT-PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPP 4215

Query: 743  ASSRSPKQARLGELPL 758
              S +P+ +R    PL
Sbjct: 4216 PESSTPQTSRSTSSPL 4231



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 1930 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 1982

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 1983 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2042

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2043 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2096

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2097 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2153

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2154 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2210

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2211 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2265

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2266 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2322

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2323 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2381

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2382 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2441

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2442 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2501

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2502 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2543



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 1953 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2005

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2006 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2065

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2066 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2119

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2120 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2176

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2177 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2233

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2234 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2288

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2289 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2345

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2346 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2404

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2405 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2464

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2465 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2524

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2525 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2566



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 1976 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2028

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2029 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2088

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2089 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2142

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2143 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2199

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2200 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2256

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2257 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2311

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2312 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2368

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2369 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2427

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2428 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2487

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2488 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2547

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2548 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2589



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 1999 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2051

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2052 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2111

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2112 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2165

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2166 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2222

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2223 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2279

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2280 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2334

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2335 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2391

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2392 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2450

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2451 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2510

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2511 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2570

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2571 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2612



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2022 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2074

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2075 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2134

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2135 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2188

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2189 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2245

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2246 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2302

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2303 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2357

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2358 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2414

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2415 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2473

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2474 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2533

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2534 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2593

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2594 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2635



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2045 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2097

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2098 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2157

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2158 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2211

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2212 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2268

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2269 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2325

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2326 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2380

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2381 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2437

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2438 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2496

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2497 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2556

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2557 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2616

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2617 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2658



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2068 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2120

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2121 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2180

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2181 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2234

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2235 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2291

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2292 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2348

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2349 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2403

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2404 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2460

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2461 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2519

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2520 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2579

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2580 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2639

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2640 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2681



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2091 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2143

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2144 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2203

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2204 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2257

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2258 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2314

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2315 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2371

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2372 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2426

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2427 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2483

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2484 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2542

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2543 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2602

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2603 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2662

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2663 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2704



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2114 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2166

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2167 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2226

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2227 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2280

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2281 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2337

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2338 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2394

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2395 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2449

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2450 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2506

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2507 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2565

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2566 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2625

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2626 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2685

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2686 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2727



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2137 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2189

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2190 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2249

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2250 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2303

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2304 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2360

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2361 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2417

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2418 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2472

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2473 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2529

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2530 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2588

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2589 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2648

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2649 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2708

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2709 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2750



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2160 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2212

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2213 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2272

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2273 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2326

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2327 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2383

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2384 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2440

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2441 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2495

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2496 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2552

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2553 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2611

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2612 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2671

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2672 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2731

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2732 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2773



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2183 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2235

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2236 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2295

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2296 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2349

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2350 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2406

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2407 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2463

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2464 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2518

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2519 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2575

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2576 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2634

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2635 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2694

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2695 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2754

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2755 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2796



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2206 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2258

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2259 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2318

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2319 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2372

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2373 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2429

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2430 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2486

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2487 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2541

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2542 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2598

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2599 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2657

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2658 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2717

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2718 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2777

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2778 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2819



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2229 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2281

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2282 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2341

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2342 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2395

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2396 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2452

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2453 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2509

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2510 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2564

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2565 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2621

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2622 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2680

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2681 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2740

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2741 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2800

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2801 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2842



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2252 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2304

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2305 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2364

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2365 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2418

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2419 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2475

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2476 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2532

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2533 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2587

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2588 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2644

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2645 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2703

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2704 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2763

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2764 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2823

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2824 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2865



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2275 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2327

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2328 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2387

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2388 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2441

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2442 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2498

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2499 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2555

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2556 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2610

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2611 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2667

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2668 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2726

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2727 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2786

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2787 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2846

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2847 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2888



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2298 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2350

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2351 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2410

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2411 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2464

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2465 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2521

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2522 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2578

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2579 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2633

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2634 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2690

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2691 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2749

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2750 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2809

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2810 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2869

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2870 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2911



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2321 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2373

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2374 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2433

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2434 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2487

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2488 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2544

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2545 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2601

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2602 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2656

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2657 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2713

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2714 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2772

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2773 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2832

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2833 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2892

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2893 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2934



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2344 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2396

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2397 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2456

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2457 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2510

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2511 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2567

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2568 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2624

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2625 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2679

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2680 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2736

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2737 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2795

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2796 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2855

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2856 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2915

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2916 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2957



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2367 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2419

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2420 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2479

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2480 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2533

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2534 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2590

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2591 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2647

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2648 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2702

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2703 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2759

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2760 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2818

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2819 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2878

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2879 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2938

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2939 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2980



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2390 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2442

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2443 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2502

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2503 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2556

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2557 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2613

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2614 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2670

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2671 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2725

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2726 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2782

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2783 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2841

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2842 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2901

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2902 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2961

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2962 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3003



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2413 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2465

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2466 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2525

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2526 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2579

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2580 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2636

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2637 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2693

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2694 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2748

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2749 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2805

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2806 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2864

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2865 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2924

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2925 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2984

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2985 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3026



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2436 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2488

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2489 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2548

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2549 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2602

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2603 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2659

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2660 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2716

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2717 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2771

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2772 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2828

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2829 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2887

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2888 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2947

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2948 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3007

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3008 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3049



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2459 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2511

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2512 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2571

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2572 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2625

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2626 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2682

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2683 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2739

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2740 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2794

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2795 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2851

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2852 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2910

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2911 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2970

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2971 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3030

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3031 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3072



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2482 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2534

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2535 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2594

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2595 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2648

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2649 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2705

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2706 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2762

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2763 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2817

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2818 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2874

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2875 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2933

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2934 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2993

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 2994 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3053

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3054 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3095



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2505 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2557

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2558 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2617

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2618 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2671

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2672 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2728

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2729 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2785

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2786 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2840

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2841 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2897

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2898 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2956

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2957 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3016

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3017 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3076

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3077 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3118



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2528 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2580

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2581 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2640

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2641 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2694

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2695 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2751

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2752 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2808

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2809 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2863

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2864 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2920

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2921 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2979

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 2980 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3039

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3040 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3099

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3100 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3141



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2551 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2603

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2604 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2663

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2664 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2717

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2718 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2774

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2775 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2831

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2832 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2886

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2887 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2943

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2944 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3002

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3003 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3062

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3063 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3122

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3123 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3164



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2574 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2626

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2627 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2686

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2687 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2740

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2741 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2797

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2798 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2854

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2855 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2909

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2910 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2966

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2967 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3025

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3026 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3085

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3086 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3145

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3146 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3187



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2597 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2649

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2650 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2709

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2710 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2763

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2764 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2820

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2821 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2877

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2878 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2932

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2933 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2989

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 2990 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3048

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3049 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3108

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3109 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3168

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3169 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3210



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2620 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2672

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2673 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2732

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2733 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2786

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2787 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2843

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2844 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2900

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2901 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2955

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2956 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3012

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3013 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3071

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3072 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3131

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3132 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3191

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3192 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3233



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2643 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2695

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2696 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2755

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2756 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2809

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2810 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2866

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2867 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2923

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2924 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2978

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 2979 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3035

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3036 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3094

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3095 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3154

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3155 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3214

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3215 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3256



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2666 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2718

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2719 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2778

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2779 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2832

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2833 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2889

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2890 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2946

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2947 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3001

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3002 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3058

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3059 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3117

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3118 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3177

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3178 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3237

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3238 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3279



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2689 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2741

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2742 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2801

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2802 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2855

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2856 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2912

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2913 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2969

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2970 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3024

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3025 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3081

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3082 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3140

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3141 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3200

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3201 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3260

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3261 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3302



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2712 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2764

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2765 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2824

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2825 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2878

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2879 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2935

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2936 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2992

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 2993 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3047

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3048 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3104

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3105 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3163

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3164 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3223

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3224 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3283

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3284 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3325



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2735 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2787

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2788 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2847

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2848 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2901

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2902 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2958

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2959 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3015

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3016 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3070

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3071 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3127

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3128 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3186

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3187 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3246

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3247 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3306

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3307 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3348



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2758 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2810

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2811 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2870

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2871 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2924

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2925 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2981

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 2982 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3038

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3039 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3093

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3094 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3150

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3151 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3209

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3210 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3269

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3270 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3329

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3330 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3371



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2781 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2833

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2834 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2893

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2894 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2947

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2948 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3004

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3005 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3061

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3062 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3116

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3117 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3173

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3174 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3232

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3233 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3292

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3293 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3352

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3353 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3394



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2804 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2856

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2857 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2916

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2917 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2970

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2971 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3027

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3028 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3084

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3085 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3139

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3140 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3196

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3197 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3255

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3256 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3315

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3316 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3375

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3376 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3417



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2827 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2879

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2880 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2939

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2940 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 2993

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 2994 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3050

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3051 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3107

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3108 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3162

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3163 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3219

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3220 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3278

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3279 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3338

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3339 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3398

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3399 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3440



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2850 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2902

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2903 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2962

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2963 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3016

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3017 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3073

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3074 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3130

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3131 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3185

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3186 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3242

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3243 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3301

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3302 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3361

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3362 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3421

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3422 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3463



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2873 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2925

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2926 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2985

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 2986 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3039

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3040 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3096

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3097 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3153

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3154 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3208

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3209 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3265

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3266 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3324

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3325 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3384

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3385 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3444

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3445 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3486



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2896 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2948

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2949 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3008

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3009 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3062

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3063 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3119

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3120 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3176

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3177 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3231

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3232 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3288

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3289 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3347

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3348 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3407

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3408 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3467

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3468 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3509



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2919 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2971

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2972 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3031

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3032 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3085

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3086 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3142

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3143 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3199

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3200 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3254

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3255 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3311

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3312 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3370

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3371 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3430

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3431 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3490

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3491 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3532



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2942 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 2994

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 2995 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3054

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3055 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3108

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3109 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3165

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3166 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3222

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3223 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3277

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3278 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3334

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3335 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3393

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3394 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3453

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3454 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3513

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3514 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3555



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2965 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3017

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3018 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3077

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3078 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3131

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3132 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3188

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3189 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3245

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3246 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3300

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3301 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3357

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3358 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3416

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3417 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3476

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3477 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3536

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3537 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3578



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 2988 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3040

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3041 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3100

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3101 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3154

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3155 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3211

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3212 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3268

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3269 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3323

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3324 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3380

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3381 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3439

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3440 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3499

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3500 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3559

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3560 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3601



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3011 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3063

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3064 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3123

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3124 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3177

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3178 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3234

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3235 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3291

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3292 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3346

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3347 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3403

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3404 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3462

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3463 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3522

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3523 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3582

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3583 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3624



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3034 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3086

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3087 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3146

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3147 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3200

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3201 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3257

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3258 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3314

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3315 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3369

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3370 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3426

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3427 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3485

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3486 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3545

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3546 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3605

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3606 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3647



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3057 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3109

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3110 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3169

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3170 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3223

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3224 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3280

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3281 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3337

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3338 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3392

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3393 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3449

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3450 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3508

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3509 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3568

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3569 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3628

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3629 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3670



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3080 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3132

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3133 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3192

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3193 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3246

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3247 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3303

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3304 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3360

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3361 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3415

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3416 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3472

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3473 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3531

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3532 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3591

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3592 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3651

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3652 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3693



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3103 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3155

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3156 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3215

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3216 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3269

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3270 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3326

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3327 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3383

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3384 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3438

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3439 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3495

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3496 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3554

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3555 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3614

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3615 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3674

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3675 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3716



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3126 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3178

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3179 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3238

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3239 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3292

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3293 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3349

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3350 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3406

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3407 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3461

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3462 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3518

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3519 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3577

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3578 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3637

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3638 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3697

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3698 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3739



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3149 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3201

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3202 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3261

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3262 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3315

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3316 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3372

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3373 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3429

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3430 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3484

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3485 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3541

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3542 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3600

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3601 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3660

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3661 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3720

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3721 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3762



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3172 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3224

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3225 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3284

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3285 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3338

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3339 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3395

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3396 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3452

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3453 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3507

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3508 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3564

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3565 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3623

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3624 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3683

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3684 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3743

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3744 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3785



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3195 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3247

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3248 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3307

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3308 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3361

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3362 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3418

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3419 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3475

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3476 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3530

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3531 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3587

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3588 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3646

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3647 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3706

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3707 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3766

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3767 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3808



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3218 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3270

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3271 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3330

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3331 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3384

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3385 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3441

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3442 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3498

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3499 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3553

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3554 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3610

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3611 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3669

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3670 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3729

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3730 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3789

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3790 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3831



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3241 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3293

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3294 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3353

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3354 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3407

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3408 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3464

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3465 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3521

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3522 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3576

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3577 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3633

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3634 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3692

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3693 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3752

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3753 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3812

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3813 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3854



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3264 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3316

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3317 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3376

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3377 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3430

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3431 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3487

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3488 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3544

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3545 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3599

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3600 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3656

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3657 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3715

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3716 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3775

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3776 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3835

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3836 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3877



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3287 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3339

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3340 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3399

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3400 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3453

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3454 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3510

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3511 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3567

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3568 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3622

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3623 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3679

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3680 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3738

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3739 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3798

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3799 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3858

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3859 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3900



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3310 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3362

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3363 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3422

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3423 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3476

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3477 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3533

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3534 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3590

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3591 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3645

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3646 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3702

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3703 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3761

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3762 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3821

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3822 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3881

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3882 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3923



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3333 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3385

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3386 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3445

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3446 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3499

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3500 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3556

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3557 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3613

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3614 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3668

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3669 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3725

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3726 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3784

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3785 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3844

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3845 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3904

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3905 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3946



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3356 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3408

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3409 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3468

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3469 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3522

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3523 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3579

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3580 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3636

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3637 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3691

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3692 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3748

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3749 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3807

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3808 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3867

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3868 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3927

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3928 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3969



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3379 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3431

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3432 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3491

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3492 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3545

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3546 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3602

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3603 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3659

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3660 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3714

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3715 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3771

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3772 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3830

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3831 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3890

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3891 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3950

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3951 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3992



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3402 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3454

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3455 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3514

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3515 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3568

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3569 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3625

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3626 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3682

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3683 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3737

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3738 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3794

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3795 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3853

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3854 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3913

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3914 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3973

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3974 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 4015



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3425 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3477

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3478 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3537

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3538 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3591

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3592 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3648

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3649 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3705

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3706 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3760

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3761 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3817

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3818 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3876

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3877 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3936

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3937 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3996

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 3997 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 4038



 Score =  101 bits (251), Expect = 3e-21
 Identities = 127/642 (19%), Positives = 210/642 (32%), Gaps = 72/642 (11%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3448 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3500

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3501 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3560

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3561 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 3614

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 3615 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3671

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 3672 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3728

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 3729 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3783

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPS 424
             +P +  T +  P+P  +P  T  P   P      +   P+P     P + P++   T +
Sbjct: 3784 TTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3840

Query: 425  P-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSL 474
            P       Q P    +       +P P+P   Q P + P   +  V+P+ TP     P+ 
Sbjct: 3841 PTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3899

Query: 475  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPS 533
                     +P  +P  + + T  P        P P       P   P   T  +   P+
Sbjct: 3900 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3959

Query: 534  PPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---------PASP 581
            P  +  P   P + + ++  +P    T  P   P+     +   P+P         P + 
Sbjct: 3960 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 4019

Query: 582  TLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
            T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 4020 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 4061



 Score =  100 bits (249), Expect = 6e-21
 Identities = 120/591 (20%), Positives = 200/591 (33%), Gaps = 68/591 (11%)

Query: 79   PTRSAGTSSRNPA---SRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLR 135
            PT    T++ NP    + P  +       P    +  P ++P   + T  P P       
Sbjct: 1882 PTTMTTTTTENPTPPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 1941

Query: 136  ISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPS 195
             +          T  P  +          +  T  TP+P         GT+     P  +
Sbjct: 1942 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITT 1995

Query: 196  ARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARS 255
                 PT  P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +
Sbjct: 1996 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPT 2052

Query: 256  G---PSARGTPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLS 300
            G   P+             P P G Q    P  TP            P     P   P++
Sbjct: 2053 GTQTPTTTPITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2109

Query: 301  SSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT 360
            ++   TP+P+    +Q P T P T    + T    TP P    +P+  P   T    P  
Sbjct: 2110 TTTTVTPTPTPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2164

Query: 361  PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASP 415
             P+   T   +P +  T +  P+P  +P  T  P   P      +   P+P     P + 
Sbjct: 2165 TPTGTQTPTTTP-ITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2221

Query: 416  PLSPLATPSP-------QAPNALAVHLLQAPFSPPPSPP-VQAPFSPP--ASPPVSPSAT 465
            P++   T +P       Q P    +       +P P+P   Q P + P   +  V+P+ T
Sbjct: 2222 PITTTTTVTPTPTPTGTQTPTTTPI-TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2280

Query: 466  PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALA 524
            P     P+          +P  +P  + + T  P        P P       P   P   
Sbjct: 2281 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2340

Query: 525  TPPLQALPSPPAS-FPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSP---- 577
            T  +   P+P  +  P   P + + ++  +P    T  P   P+     +   P+P    
Sbjct: 2341 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2400

Query: 578  -----PASPTLQAPRRPPTPGPDTSVSGP-RLTLALAPGPPPPPSRSPSST 622
                 P + T      P   G  T  + P   T  + P P P  +++P++T
Sbjct: 2401 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2451



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 141/682 (20%), Positives = 225/682 (32%), Gaps = 96/682 (14%)

Query: 16   TPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAP 75
            TP+       TP P  +P PP   TP+   +          P           T P +  
Sbjct: 1561 TPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTT---TTTTPPPTTT 1617

Query: 76   RAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLR 135
             + PT +  T   +  + PP +      PP   T+P P ++P   + TT   P+      
Sbjct: 1618 PSPPTTTPITPPTSTTTLPPTT--TPSPPPTTTTTPPPTTTPSPPTTTTPSPPI------ 1669

Query: 136  ISAEETVARGKATEAPKRSALSAGARRDTSGPTPG---TPSPAMARRSRAAGTEVGLP-- 190
                 T      T  P     +  +   T+  TP    TPS  +   +  + T    P  
Sbjct: 1670 ----TTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPP 1725

Query: 191  ----RPAPSARPRPPTEG----PRKSVSSA---------------SEHSTTEPSPAARRR 227
                 P+P+  P PPT      P  + SS                S  STT P+      
Sbjct: 1726 TTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTPTTPCVPL 1785

Query: 228  PSAGGGLQ--RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQAL----- 280
             +  G L   +P           +      G +A  + RA  +P  P  +  Q +     
Sbjct: 1786 CNWTGWLDSGKPNFHKPGGDTELIGDVCGPGWAANISCRATMYPDVPIGQLGQTVVCDVS 1845

Query: 281  ----------RPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSL 330
                      +P  V P        +       +  P+      ++ P T P T   ++ 
Sbjct: 1846 VGLICKNEDQKPGGVIPMAFCLNYEINVQCCECVTQPTTMTTTTTENP-TPPTTTPITTT 1904

Query: 331  TCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA 390
            T    TP P    +P+  P   T    P   P+   T   +P +  T +  P+P  +P  
Sbjct: 1905 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTP--TPTG 1961

Query: 391  TPPPQAPPALALPPLQAPPSP-----PASPPLSPLATPSP-------QAPNALAVHLLQA 438
            T  P   P      +   P+P     P + P++   T +P       Q P    +     
Sbjct: 1962 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-TTTT 2020

Query: 439  PFSPPPSPP-VQAPFSPP--ASPPVSPSATPPSQAPPSLA--APPLQVPPSPPASPPMSP 493
              +P P+P   Q P + P   +  V+P+ TP     P+         V P+P  +   +P
Sbjct: 2021 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2080

Query: 494  SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPAS-FPGQAPF-------- 544
            + T P      +   P       P   P   T  +   P+P  +  P   P         
Sbjct: 2081 TTT-PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 2139

Query: 545  SPSASLPMSPLATPPPQAPPVLAAPL---LQVPPSPPASPTLQAPRRPPTPGPDTSVSGP 601
            +P+ +   +P  TP      V   P     Q P + P + T      P   G  T  + P
Sbjct: 2140 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2199

Query: 602  -RLTLALAPGPPPPPSRSPSST 622
               T  + P P P  +++P++T
Sbjct: 2200 ITTTTTVTPTPTPTGTQTPTTT 2221



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 128/620 (20%), Positives = 196/620 (31%), Gaps = 93/620 (15%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3839 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3891

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3892 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3951

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 3952 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 4005

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 4006 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 4062

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 4063 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 4119

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +    +Q P T P T    + T    TP P    +P+  P   T    P   P+   T  
Sbjct: 4120 TPT-GTQTPTTTPIT----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 4174

Query: 370  GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPL-QAPPSPPASPPLSPLATPSPQAP 428
             +P +  T +  P+P  +   T PP       +  L  + P P +S P +  +T SP   
Sbjct: 4175 TTP-ITTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTE 4233

Query: 429  NALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 488
            +   +  L         P ++   + P S P +P+ T             L  PPS   S
Sbjct: 4234 STTLLSTL--------PPAIEMTSTAPPSTPTAPTTTSGGHT--------LSPPPSTTTS 4277

Query: 489  PPMSP--------SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPS------- 533
            PP +P        S+ P P                P   P  + T  L+  PS       
Sbjct: 4278 PPGTPTRGTTTGSSSAPTPSTVQTTTTSAWTPTPTPLSTPSIIRTTGLRPYPSSVLICCV 4337

Query: 534  --PPASFPGQAPF-------------SPSASLPM---SPLATPPPQAPPVLAAPLLQVPP 575
                   PG+  +             S S +L     S  +TP P   P  + P    P 
Sbjct: 4338 LNDTYYAPGEEVYNGTYGDTCYFVNCSLSCTLEFYNWSCPSTPSPTPTPSKSTPTPSKPS 4397

Query: 576  SPPASPTLQAPRRPPTPGPD 595
            S P+ PT   P   P   PD
Sbjct: 4398 STPSKPT---PGTKPPECPD 4414



 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 112/533 (21%), Positives = 176/533 (33%), Gaps = 77/533 (14%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            +TP P  +    P  TP               P     G     T P +           
Sbjct: 3908 VTPTPTPTGTQTPTTTPITTTTTVT-------PTPTPTGTQTPTTTPITTTTTVTPTPTP 3960

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144
            T ++ P + P  +       P    +  P ++P   + T  P P        +       
Sbjct: 3961 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 4020

Query: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204
               T  P  +          +  T  TP+P         GT+     P  +     PT  
Sbjct: 4021 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTPTTTPITTTTTVTPTPT 4074

Query: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARG 261
            P  + +  +   TT  +      P+   G Q P +  ++++ T   +P  +G   P+   
Sbjct: 4075 PTGTQTPTTTPITTTTTVTPTPTPT---GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 4131

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTP------------PRKDAAPALGPLSSSPLATPSP 309
                      P P G Q    P  TP            P     P   P++++   TP+P
Sbjct: 4132 ITTTTTVTPTPTPTGTQT---PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 4188

Query: 310  SAALQSQAPPTLPAT------------PHSSSLTCQLATPLPLAPPSP---SAPPSLQ-T 353
            +       PPT  +T            P SS+     +T  PL   +    + PP+++ T
Sbjct: 4189 TPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMT 4248

Query: 354  LPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPA 413
              +PP+TP +  TTS G  TL    S   SPP +P       +  A     +Q   +   
Sbjct: 4249 STAPPSTPTAPTTTS-GGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAW 4307

Query: 414  SPPLSPLATPS--------PQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA--------- 456
            +P  +PL+TPS        P   + L   +L   +  P        +             
Sbjct: 4308 TPTPTPLSTPSIIRTTGLRPYPSSVLICCVLNDTYYAPGEEVYNGTYGDTCYFVNCSLSC 4367

Query: 457  -------SPPVSPSATP-PSQAPPSLAAPP-LQVPPSPPASPPMSPSATPPPQ 500
                   S P +PS TP PS++ P+ + P      P+P   PP  P   PP Q
Sbjct: 4368 TLEFYNWSCPSTPSPTPTPSKSTPTPSKPSSTPSKPTPGTKPPECPDFDPPRQ 4420


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score =  153 bits (387), Expect = 6e-37
 Identities = 239/837 (28%), Positives = 315/837 (37%), Gaps = 151/837 (18%)

Query: 17   PAARAPG--LLTPRPP-----------------GSPRPPPPV-----TPAALRVLGAAGA 52
            PA+R PG  LL P  P                 G+ RPP P      TP A   L  A  
Sbjct: 1062 PASRPPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPP 1121

Query: 53   VGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGR-------GERAPP 105
             G   L +      G T P +A     T +A  ++    +  PA  R         R P 
Sbjct: 1122 PGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPS 1181

Query: 106  AKNTSPGPVSS----PGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKR------SA 155
             +  S G ++S    P   +G ++P     +G +++      R  A   P+         
Sbjct: 1182 GEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHL 1241

Query: 156  LSAGARRD----------------TSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPR 199
            +SAG +                  T GPTP +  P+    +  A T + LP  A      
Sbjct: 1242 VSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQV--- 1298

Query: 200  PPT----EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSS--SATPLSSPA 253
            PPT     G  K V   +      P P     P       RP S  L +  +  P  +P 
Sbjct: 1299 PPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAP-------RPPSSGLPAVLNPRPTLTPG 1351

Query: 254  RSGPSARGTPRAPAH-PSQPKPKGLQALRP-PQVTPPRKDAAPAL------------GPL 299
            R      GT RAP   P+  +P       P P+V+     AAP              GP 
Sbjct: 1352 RLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPA 1411

Query: 300  SS-------SPLATPSPS-------AALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSP 345
            SS       SPLA+P  S       ++L    P TLPA P S+ LT  ++ PL ++   P
Sbjct: 1412 SSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPA-PASAPLTIPISAPLTVSASGP 1470

Query: 346  S-----APPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQ---AP 397
            +      PP    +P+ P  PPS A +         T     +P LS   TP      AP
Sbjct: 1471 ALLTSVTPPLAPVVPAAPG-PPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAP 1529

Query: 398  PALALPPLQAPPSPPASP---PLSPLATPSPQAPN-ALAVHLLQAPFSPPPSPPVQAPFS 453
             +  +P L +  +P  SP   P S LA+P P APN A A   L AP S   S  +  P +
Sbjct: 1530 TSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPAS-SASQALATPLA 1588

Query: 454  PPASPP---VSPSATPPSQAPPSLAAPPLQVP---PSPPASPPMSPSATP--------PP 499
            P A+P    ++PS  PP    P LA  P   P    S    P M+PS+TP        P 
Sbjct: 1589 PMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPV 1648

Query: 500  QAPPPLAAPPLQLAKPPPQAPPALATP-PLQALPSPPASFPGQAPFSPSASLPMSPLATP 558
             AP P+ AP       P   P  L +P   Q L   PA  P     SPS +L    L T 
Sbjct: 1649 PAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTL---SLGTG 1705

Query: 559  PPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR- 617
             PQ P       L + P+    PT  A      PGP     GP  TL+LAP PP  P+  
Sbjct: 1706 NPQGP--FPTQTLSLTPASSLVPT-PAQTLSLAPGPPL---GPTQTLSLAPAPPLAPASP 1759

Query: 618  ---SPSSTLSGPDLAGHSSSAT-STPEELRGYDSGPEGGAAASPPPDAELAACHPAAWS- 672
               +P+ TL+   LA  SSSA+   P  ++     P       P     LA    +  S 
Sbjct: 1760 VGPAPAHTLT---LAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSP 1816

Query: 673  RGPAPPLAFRGAPGAPLPWPPATG-PGSADGLCTIYETEGPESATPAPGALDPGPSP 728
               A  L    +  APLP    +  P S D   T+    GP S  P+      GP P
Sbjct: 1817 ASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPS-PPSTATSFGGPRP 1872



 Score =  140 bits (352), Expect = 7e-33
 Identities = 182/623 (29%), Positives = 241/623 (38%), Gaps = 85/623 (13%)

Query: 13   AARTPAARAPGLLTPRPPGSP-RPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIP 71
            A R P++  P +L PRP  +P R P P    A   +     V  +PL +         + 
Sbjct: 1330 APRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLV--RPLLKLVHS-PSPEVS 1386

Query: 72   ESAPRAGPTRSAG-----TSSRNPASRP-PASGRGERAPPAKNTSPGPVSSPGRAS-GTT 124
             SAP A P   +      +S   PAS P P       A P  +T   P+SS    S  TT
Sbjct: 1387 ASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTT 1446

Query: 125  RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP-SPAMARRSRAA 183
             P P                     AP    +SA      SGP   T  +P +A      
Sbjct: 1447 LPAP-------------------ASAPLTIPISAPLTVSASGPALLTSVTPPLA------ 1481

Query: 184  GTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS---TTEPSPAARRRPSAGGGLQRPASR 240
                    P   A P PP+  P  +  SAS  +    T PS ++ + P     L   +S 
Sbjct: 1482 --------PVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSH 1533

Query: 241  --SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP 298
               L+S+  P  SP     SA  +P     PS P P   QA      +   +  A  L P
Sbjct: 1534 VPGLNSTVAPACSPVLVPASALASP----FPSAPNPAPAQASLLAPASSASQALATPLAP 1589

Query: 299  LSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPP 358
            +++   A  +PS A      P L  +P ++ +     TP+P+  PS +   SL +    P
Sbjct: 1590 MAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVP 1649

Query: 359  ATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLS 418
            A  P  A +S        T + LP+P  SPL  P P +   LAL P  AP    +SP  +
Sbjct: 1650 APTPVLAPSS--------TQTMLPAPVPSPL--PSPASTQTLALAPALAPTLGGSSPSQT 1699

Query: 419  -PLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP 477
              L T +PQ P       L    S  P+P      +P   PP+ P+ T  S AP    AP
Sbjct: 1700 LSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAP--GPPLGPTQT-LSLAP----AP 1752

Query: 478  PLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPPALATPPLQALPSPPA 536
            PL  P SP    P       P  +   L AP  +Q     P   P L     Q L   PA
Sbjct: 1753 PL-APASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPA 1811

Query: 537  SFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT 596
            S   Q+P S ++SL +S     P    PV     L V    P + TL++   P  P   T
Sbjct: 1812 S--TQSPASQASSLVVSASGAAP---LPVTMVSRLPVSKDEPDTLTLRS-GPPSPPSTAT 1865

Query: 597  SVSGPRLTLALAPGPPPPPSRSP 619
            S  GPR         PPPP RSP
Sbjct: 1866 SFGGPR-----PRRQPPPPPRSP 1883



 Score =  117 bits (294), Expect = 3e-26
 Identities = 195/750 (26%), Positives = 269/750 (35%), Gaps = 161/750 (21%)

Query: 30   PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRN 89
            P +P  P PV P     L A    G  P       +  A++  SA  AGP          
Sbjct: 1015 PRAPLGPVPVRPPPGPELSAQPTPGPVPQ------VLPASLMVSASPAGPPLI------- 1061

Query: 90   PASRPPASGRGERAPPAKNTSPGPVSSP-GRASGTTRPGPLGQKGLRISAEETVARGKAT 148
            PASRPP         P   + P  + SP G  SGT+RP P     L+ +    V    A 
Sbjct: 1062 PASRPPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRP-PTPTLSLKPTPPAPVRLSPAP 1120

Query: 149  EAPKRSALSAGARRDTSGPTPGTPSPAMARRSR---AAGTEVGLPRPAPSARPRPPTEGP 205
                 S L     +  + P   T  PA A  +    A  T   +P P P+ +    +   
Sbjct: 1121 PPGSSSLL-----KPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDM 1175

Query: 206  RKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA 265
            +  + S    S  + +  A+R P A  G  +P +  +  +   L+  A+    A G PR 
Sbjct: 1176 QARLPSGEVVSIGQLASLAQR-PVANAGGSKPLTFQIQGNKLTLTG-AQVRQLAVGQPR- 1232

Query: 266  PAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATP 325
                                 P +++    +       L +     AL     PT   TP
Sbjct: 1233 ---------------------PLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTP 1271

Query: 326  HSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTL---QATHSFL- 381
             S          LP + PS +  P+  +LP      P     + G   +   QA    L 
Sbjct: 1272 VSV---------LPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLT 1322

Query: 382  PSPPLSPLATPPPQAPPALALP-PLQAP---PSPPASPPLSPLATPSPQAPNALAVHLLQ 437
            P PPL+P   PP    PA+  P P   P   P+P      +P+ TP+   P    VH   
Sbjct: 1323 PVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVH--- 1379

Query: 438  APFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP---PLQVPPSPPASPPMSPS 494
                  PSP V A  S P + P++ S+  P   P SL  P   P+ +P S P + P+S +
Sbjct: 1380 -----SPSPEVSA--SAPGAAPLTISS--PLHVPSSLPGPASSPMPIPNSSPLASPVSST 1430

Query: 495  ATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 554
             + P  +  P++ P                   L A  S P + P  AP + SAS P   
Sbjct: 1431 VSVPLSSSLPISVPTT-----------------LPAPASAPLTIPISAPLTVSASGPALL 1473

Query: 555  LATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPD-TSVSGPRLTLALAPGPPP 613
             +  PP AP V AAP                   PP+  P   S S   LTL LA  P  
Sbjct: 1474 TSVTPPLAPVVPAAP------------------GPPSLAPSGASPSASALTLGLATAP-- 1513

Query: 614  PPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSR 673
                    +LS     GH      T   + G +S      +    P + LA+  P+A + 
Sbjct: 1514 --------SLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNP 1565

Query: 674  GP----------------APPLAFRGAPG----APLPWPP-------ATGPGSADGLCTI 706
             P                A PLA   AP     AP P PP       A  PG+A  L + 
Sbjct: 1566 APAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLAS- 1624

Query: 707  YETEGPESATPAPGALDPGPSPGTSGGKAA 736
                   S TP P  + P  +PGTS   A+
Sbjct: 1625 -------SQTPVP-VMAPSSTPGTSLASAS 1646



 Score =  100 bits (250), Expect = 4e-21
 Identities = 168/655 (25%), Positives = 236/655 (36%), Gaps = 103/655 (15%)

Query: 218  TEPSPAARRRP--SAGGGLQRPASRSLSSSATPLSSP-ARSGPSARGTPRAPAHPSQPKP 274
            T P P  R +P       + +P  +    +   +++P A  GP     P  P   +QP P
Sbjct: 979  TAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRPPPGPELSAQPTP 1038

Query: 275  KGLQALRP---------------PQVTPPRKDAAPALGPLSSS-PLATPSPSAALQSQAP 318
              +  + P               P   PP     P L P S S P   PSP   L   + 
Sbjct: 1039 GPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSR 1098

Query: 319  PTLPATPHSSSLTCQLATPLPLAP-PSPSAPPSLQTLPSPPA-TPPSQATTSLGSPTLQA 376
            P  P      SL      P+ L+P P P +   L+ L  PP  T P  A T+  + T  A
Sbjct: 1099 PPTPTL----SLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATA 1154

Query: 377  THSFLPSPPLSP---LATPPPQAP------------PALALPPL-QAPPSPPAS------ 414
            T + +P+P  +P   + +P  QA              +LA  P+  A  S P +      
Sbjct: 1155 TTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGN 1214

Query: 415  ------PPLSPLATPSPQAPNALAVHLLQAP------FSPPPSPPVQAPFSPPASPPVS- 461
                    +  LA   P+      VHL+ A         P     +QA    P   PVS 
Sbjct: 1215 KLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSV 1274

Query: 462  -PSATPPSQAPPSLAAPPLQVPPSPPA-------------SPPMSPSATPPPQAP---PP 504
             PS+TP +   P+  + PL     PP                P       PP AP   PP
Sbjct: 1275 LPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPP 1334

Query: 505  LAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPP 564
             +  P  L   P   P  L TP L    +P  +     P       P   ++   P A P
Sbjct: 1335 SSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAP 1394

Query: 565  VLAAPLLQVPPS--PPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPP---PPPSRSP 619
            +  +  L VP S   PAS  +  P   P   P +S     L+ +L    P   P P+ +P
Sbjct: 1395 LTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAP 1454

Query: 620  SST-LSGPDLAGHSSSA--TSTPEELRGYDSGPEGGAAASPPPDAELAACHPAA---WSR 673
             +  +S P     S  A  TS    L      P   AA  PP  A   A   A+      
Sbjct: 1455 LTIPISAPLTVSASGPALLTSVTPPL-----APVVPAAPGPPSLAPSGASPSASALTLGL 1509

Query: 674  GPAPPLAFRGAPGAPLPWPPATG--PG---SADGLCTIYETEGPESATPAPGALDPGPSP 728
              AP L+    PG PL   P +   PG   +    C+         A+P P A +P P+ 
Sbjct: 1510 ATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQ 1569

Query: 729  GTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAA 783
             +    A++ + A A+  +P  A     P  A+ A      L+   +LA + GAA
Sbjct: 1570 ASLLAPASSASQALATPLAPMAA-----PQTAILAPSPAPPLAPLPVLAPSPGAA 1619



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 178/676 (26%), Positives = 241/676 (35%), Gaps = 102/676 (15%)

Query: 102  RAPPAKNTSPGP--VSSPGRASGTTRPGPLGQK----GLRISAEETVARGKATEAPKRSA 155
            R P  +   PG    SS G   GT R     +     G R+S     AR +   A     
Sbjct: 2355 RLPQEEEEGPGAGDESSCGTGGGTHRRSKKAKAPERPGTRVSERLRGARAETQGANHTPV 2414

Query: 156  LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH 215
            +SA   R T+  TP   SPA  R          +PRPAP  RPRP       ++ +    
Sbjct: 2415 ISAHQTRSTT--TPPRCSPARER----------VPRPAP--RPRPTPASAPAAIPALVPV 2460

Query: 216  STTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPK 275
              + P P +   P     +    S    S   P SSPA + P A   P  PAH   P   
Sbjct: 2461 PVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSSPACTPPPACTPP--PAHTPPPAQT 2518

Query: 276  GLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLA 335
             L     P +  P   + P    +++ PL    P A L +QA  + P +   +S+     
Sbjct: 2519 CLVTPSSPLLLGP--PSVPISASVTNLPLGL-RPEAELCAQALAS-PESLELASVASSET 2574

Query: 336  TPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPS-----PPLSPLA 390
            + L L PP    P +++ LP          + +  +P+L      +P+      P S   
Sbjct: 2575 SSLSLVPPKDLLPVAVEILP----VSEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEG 2630

Query: 391  TPPPQAPPALALP-------PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 443
            T     P    LP        L+ PPS  +  PL       P   +  +  L +A  +P 
Sbjct: 2631 TTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQ-----EPLEADRTSEELTEAK-TPT 2684

Query: 444  PSP--PVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQA 501
             SP  P +   +  A+P  S SAT  S   PS A PP +      A   +    T  P  
Sbjct: 2685 SSPEKPQELVTAEVAAPSTSSSAT-SSPEGPSPARPPRR---RTSADVEIRGQGTGRPGQ 2740

Query: 502  PPPLAAPPLQLAKPPPQAPPALATPPL-----QALPSPPASFPGQAPFSPSASLP----M 552
            PP     P  L K P +    +    L     Q   +     PG +  S S   P    M
Sbjct: 2741 PP----GPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSM 2796

Query: 553  SPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPR-RPPTPGPDTSVSGPRLTLALAP-- 609
            S   + PP   P  AAP   + P+PP  P +          G  +  +G    LA+ P  
Sbjct: 2797 SGPESSPPIGGPCEAAPSSSL-PTPPQQPFIARRHIELGVTGGGSPENGDGALLAITPPA 2855

Query: 610  -----GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYD--SGPEGGAAASPPPDAE 662
                 G PP  +RSP+    G D A  S+    T     G D   GPE    A P  + +
Sbjct: 2856 VKRRRGRPPKKNRSPADAGRGVDEAPSSTLKGKT----NGADPVPGPETLIVADPVLEPQ 2911

Query: 663  LAACHPAAWSRGPAP-----PLAF------RGAPGAPLPWP-PATGPGSADGLCTIYETE 710
            L    P     GP P     PL        RG P      P P T   + DG      +E
Sbjct: 2912 LI---PGPQPLGPQPVHRPNPLLSPVEKRRRGRPPKARDLPIPGTISSAGDG-----NSE 2963

Query: 711  GPESATPAPGALDPGP 726
                  P P  L P P
Sbjct: 2964 SRTQPPPHPSPLTPLP 2979



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 123/439 (28%), Positives = 159/439 (36%), Gaps = 78/439 (17%)

Query: 355  PSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAP---PSP 411
            P  P T  S+      + T  A H+ + S   +   T PP+  PA    P  AP   P+P
Sbjct: 2388 PERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPRCSPARERVPRPAPRPRPTP 2447

Query: 412  PASPPLSPLATPSP-------QAPNA---LAVHLLQAPFSPPPS--PPVQAPFSPPASPP 459
             ++P   P   P P        APN    L VH+L +P  PPPS  PP     SP  +PP
Sbjct: 2448 ASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSP--PPPSQIPPCS---SPACTPP 2502

Query: 460  VSPSATPPSQAPPSLAAPPLQVPPSP----PASPPMSPSATPPPQAPPP--------LAA 507
              P+ TPP    P  A   L  P SP    P S P+S S T  P    P        LA+
Sbjct: 2503 --PACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALAS 2560

Query: 508  P-PLQLAKPPPQAPPALA-TPPLQALPSPPASFP------GQAPFSPSASLPMSPLATPP 559
            P  L+LA        +L+  PP   LP      P         P +PS +L    +    
Sbjct: 2561 PESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQ 2620

Query: 560  PQAPPVLA-------------APL-------LQVPPSPPASPTLQAPRRPPTPGPD---- 595
             Q  P  A              PL       L++PPS  +   LQ P        +    
Sbjct: 2621 EQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEA 2680

Query: 596  -TSVSGPRLTLALAPGPPPPPSRSPSSTLS--GPDLAGHSSSATSTPEELRGYDSG---- 648
             T  S P     L       PS S S+T S  GP  A      TS   E+RG  +G    
Sbjct: 2681 KTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQ 2740

Query: 649  PEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYE 708
            P G       P   +         R        RGA    +P    T   ++ G  ++  
Sbjct: 2741 PPGPKVLRKLPGRLVTVVEEKELVRRRRQQ---RGAASTLVPGVSET--SASPGSPSVRS 2795

Query: 709  TEGPESATPAPGALDPGPS 727
              GPES+ P  G  +  PS
Sbjct: 2796 MSGPESSPPIGGPCEAAPS 2814



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 156/584 (26%), Positives = 206/584 (35%), Gaps = 97/584 (16%)

Query: 12   AAARTPAARAPGLLTP-RPPGSPRPPPPVTPAALRVLGAAGAVGRKPLA-ERAGGIGGAT 69
            +A  T +A  P LLT   PP +P  P    P +L   GA+ +     L    A  +  + 
Sbjct: 1460 SAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQ 1519

Query: 70   IPESAPRAGPTRS---AGTSSRNPASRP---PASGRGERAPPAKNTSPG------PVSSP 117
             P       PT S      S+  PA  P   PAS      P A N +P       P SS 
Sbjct: 1520 TPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSA 1579

Query: 118  GRASGTT-RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGP------TPG 170
             +A  T   P    Q  +   +           AP   A    A   T  P      TPG
Sbjct: 1580 SQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPG 1639

Query: 171  T------PSPAMARRSRAAGTEVGLPRPAPSARPRP---------PTEGPRKSVSSASEH 215
            T      P PA       + T+  LP P PS  P P         P   P    SS S+ 
Sbjct: 1640 TSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQT 1699

Query: 216  ------STTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHP 269
                  +   P P      +    L    +++LS +  P   P ++   A   P APA P
Sbjct: 1700 LSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASP 1759

Query: 270  SQPKPKGLQALRPPQVTPPRKDAAPALGP-------LSSSPLATPSPSAALQSQAPPTLP 322
              P P     L P         +A  L P       LS +P+ T  P+AA      P   
Sbjct: 1760 VGPAPAHTLTLAPAS------SSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPAST 1813

Query: 323  ATPHSSS----LTCQLATPLPLA-----PPSPSAPPSLQTLPSPPATPPSQATTSLGSPT 373
             +P S +    ++   A PLP+      P S   P +L TL S P +PPS AT+  G   
Sbjct: 1814 QSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTL-TLRSGPPSPPSTATSFGG--- 1869

Query: 374  LQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALA- 432
                    P P   P   PPP++P    L  L+       S  L  +   S +A  ALA 
Sbjct: 1870 --------PRPRRQP--PPPPRSP--FYLDSLEEKRKRQRSERLERIFQLS-EAHGALAP 1916

Query: 433  VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ------------ 480
            V+  +         PV +P  P +  P  P+    ++A       P Q            
Sbjct: 1917 VYGTEVLDFCTLPQPVASPIGPRSPGPSHPTFWTYTEAAHRAVLFPQQRLDQLSEIIERF 1976

Query: 481  --VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP-PQAPP 521
              V P   A PP   +  PPP   P  AA   QLA    P+A P
Sbjct: 1977 IFVMPPVEAPPPSLHACHPPPWLAPRQAAFQEQLASELWPRARP 2020



 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 197/811 (24%), Positives = 266/811 (32%), Gaps = 172/811 (21%)

Query: 27   PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPL-AERAGGIGGATIPESAPRAG--PTRSA 83
            PRP   PRP P   PAA+  L         P+ A     I    I  S P     P  S+
Sbjct: 2437 PRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSS 2496

Query: 84   GTSSRNPASRPPASGRGERAPPAKN-----TSP---GPVSSPGRASGTTRPGPLGQKGLR 135
               +  PA  PP +      PPA+      +SP   GP S P  AS T  P      GLR
Sbjct: 2497 PACTPPPACTPPPA---HTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLP-----LGLR 2548

Query: 136  ISAEETVARGKATEAPKRSALSAGARRDTS-------------------------GPTPG 170
              AE      +A  +P+   L++ A  +TS                           TP 
Sbjct: 2549 PEAE---LCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPS 2605

Query: 171  TPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSA 230
             PS  +   S   G E   P  A         EG    +  +  +    P  AA   P  
Sbjct: 2606 APSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEP-- 2663

Query: 231  GGGLQRP-----ASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQ--PKPKGLQALRPP 283
               LQ P      S  L+ + TP SSP +          AP+  S     P+G    RPP
Sbjct: 2664 ---LQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPP 2720

Query: 284  QVTPPRKDAAPA--LGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQ-------L 334
            +    R+ +A     G  +  P   P P   +  + P  L        L  +        
Sbjct: 2721 R----RRTSADVEIRGQGTGRPGQPPGPK--VLRKLPGRLVTVVEEKELVRRRRQQRGAA 2774

Query: 335  ATPLPLAPPSPSAP--PSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSP---- 388
            +T +P    + ++P  PS++++  P ++PP      +G P   A  S LP+PP  P    
Sbjct: 2775 STLVPGVSETSASPGSPSVRSMSGPESSPP------IGGPCEAAPSSSLPTPPQQPFIAR 2828

Query: 389  --------------------LATPPPQAPPALALPPLQAPPSPPA-----SPPLSPL--- 420
                                LA  PP        PP +      A       P S L   
Sbjct: 2829 RHIELGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPSSTLKGK 2888

Query: 421  ---ATPSPQAPNALAV--HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA 475
               A P P  P  L V   +L+    P P P    P   P +P +SP        PP   
Sbjct: 2889 TNGADPVP-GPETLIVADPVLEPQLIPGPQPLGPQPVHRP-NPLLSPVEKRRRGRPPK-- 2944

Query: 476  APPLQVPPS-PPASPPMSPSATPPPQAPPPLA-APPLQLAKPPPQAPPALATPPLQALPS 533
            A  L +P +   A    S S T PP  P PL   PPL +    P A  A     +    S
Sbjct: 2945 ARDLPIPGTISSAGDGNSESRTQPPPHPSPLTPLPPLLVC---PTATVANTVTTVTISTS 3001

Query: 534  PPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPG 593
            PP    G+ P +P          +P P   PVL      V  S       Q   +  + G
Sbjct: 3002 PPKRKRGRPPKNP---------PSPRPSQLPVLDRDSTSVLESCGLGRRRQPQGQGESEG 3052

Query: 594  PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATST----PEELRGYDSGP 649
              +   G R           P +R     L    + G  S  +       ++L   DSGP
Sbjct: 3053 SSSDEDGSR-----------PLTRLARLRLEAEGMRGRKSGGSMVVAVIQDDLDLADSGP 3101

Query: 650  EG--------------------GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPL 689
             G                      +  PP + E      A    G +P LA RG    P 
Sbjct: 3102 GGLELTPPVVSLTPKLRSTRLRPGSLVPPLETEKLPRKRAGAPVGGSPGLAKRGRLQPPS 3161

Query: 690  PWPPATGPGSADGLCTIYETEGPESATPAPG 720
            P  P      ++   +  E EG  +    PG
Sbjct: 3162 PLGPEGSVEESEAEASGEEEEGDGTPRRRPG 3192



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 108/456 (23%), Positives = 152/456 (33%), Gaps = 65/456 (14%)

Query: 379  SFLPSPPLS-------PLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNAL 431
            +FLP   LS         A  PP  P  + +   +     P     + +   +P+AP   
Sbjct: 962  TFLPRHRLSRRVLLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAP--- 1018

Query: 432  AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM 491
               L   P  PPP P + A  +P   P V P++   S +P      P   PP P   PP+
Sbjct: 1019 ---LGPVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPL 1075

Query: 492  SPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLP 551
             P++   PQ  P         ++PP        TP L   P+PPA         P +S  
Sbjct: 1076 QPNSGSLPQVLPSPLGVLSGTSRPP--------TPTLSLKPTPPAPVRLSPAPPPGSSSL 1127

Query: 552  MSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGP 611
            + PL  PP    P  AA       +   +  + A    PTP P   +  P +   L  G 
Sbjct: 1128 LKPLTVPPGYTFPPAAATTTSTTTATATTTAVPA----PTPAPQRLILSPDMQARLPSGE 1183

Query: 612  PPPPSRSPSSTLSGPDLAGHS---------SSATSTPEELRGYDSG-------------P 649
                 +  S        AG S         +  T T  ++R    G              
Sbjct: 1184 VVSIGQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVS 1243

Query: 650  EGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATG-PGSAD------- 701
             GG        A +A     A + GP P      +  +  P P     P +A+       
Sbjct: 1244 AGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMV 1303

Query: 702  ---GLCTIYETEGP-ESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELP 757
               G+  I   + P +  TP P  L P P P +SG  A        +       RL    
Sbjct: 1304 NNTGVVKIVVRQAPRDGLTPVP-PLAPAPRPPSSGLPAVLNPRPTLT-----PGRLPTPT 1357

Query: 758  LGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGA 793
            LG  +A +    L R LL      +   S   PG A
Sbjct: 1358 LGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAA 1393



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 83/365 (22%), Positives = 117/365 (32%), Gaps = 46/365 (12%)

Query: 8    AKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGG 67
            A A A A T    +P        G+P+ P P    +L    +      + L+   G   G
Sbjct: 1682 ALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLG 1741

Query: 68   ATIPES---APRAGPTRSAGTSSRNPASRPPASGRGERAPPAK----NTSPGPVSSPGRA 120
             T   S   AP   P    G +  +  +  PAS       PA       SP PV + G A
Sbjct: 1742 PTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPA 1801

Query: 121  SGTT---RPGPLGQKGLRISAEETVARGKA---TEAPKRSALSAGARRDTSGPTPGTPSP 174
            +  T    P        + S+    A G A        R  +S     DT     G PSP
Sbjct: 1802 AAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKD-EPDTLTLRSGPPSP 1860

Query: 175  AMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGL 234
                   +  T  G PRP     P P +     S+    +   +E      +   A G L
Sbjct: 1861 P------STATSFGGPRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGAL 1914

Query: 235  QRPASRSLSSSAT---PLSSPARSGPSARGTPRAPAHPS---QPKPKGLQALRPPQ---- 284
                   +    T   P++SP   GP + G    P+HP+     +      L P Q    
Sbjct: 1915 APVYGTEVLDFCTLPQPVASPI--GPRSPG----PSHPTFWTYTEAAHRAVLFPQQRLDQ 1968

Query: 285  ----------VTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQL 334
                      V PP +   P+L      P   P  +A  +  A    P       + C +
Sbjct: 1969 LSEIIERFIFVMPPVEAPPPSLHACHPPPWLAPRQAAFQEQLASELWPRARPLHRIVCNM 2028

Query: 335  ATPLP 339
             T  P
Sbjct: 2029 RTQFP 2033


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score =  152 bits (383), Expect = 2e-36
 Identities = 189/771 (24%), Positives = 269/771 (34%), Gaps = 102/771 (13%)

Query: 2   DNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAER 61
           DNK+++ K     + P     G            P   T    +V  +      KP+  R
Sbjct: 68  DNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPR 127

Query: 62  AG-GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA 120
                   T  E++       +  T      ++  ++   E+   AK T     +S    
Sbjct: 128 PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDL 187

Query: 121 SGTTR----PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAM 176
           + T++    P P           ET  +G A   PK    +    ++ +  TP  P+P  
Sbjct: 188 APTSKVLAKPTPKA---------ETTTKGPALTTPKEPTPTTP--KEPASTTPKEPTPTT 236

Query: 177 ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQR 236
            + +     E     PAP+     PT  P++   +    +T EP+P   + P A    + 
Sbjct: 237 IKSAPTTPKE-----PAPTTTKSAPTT-PKEPAPT----TTKEPAPTTPKEP-APTTTKE 285

Query: 237 PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296
           PA  +  S+ T    PA + P  +  P  P  P+   PK      P +  P  K+ AP  
Sbjct: 286 PAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 344

Query: 297 GPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPS 356
            P   +P A   P+     +  PT P  P           P     PSP+ P      P+
Sbjct: 345 -PKEPAPTAPKKPAPTTPKEPAPTTPKEP----------APTTTKEPSPTTPKE----PA 389

Query: 357 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT--PPPQAP--PALALPPLQAPPSPP 412
           P  T  +  TT   +PT   +    P  P SP  T  P P  P  PA   P   AP +P 
Sbjct: 390 PTTTKSAPTTTKEPAPTTTKSAPTTPKEP-SPTTTKEPAPTTPKEPAPTTPKKPAPTTPK 448

Query: 413 ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ-APFSPPASPPVSPSATPPSQAP 471
              P     TP   AP          P  P P+ P + AP +P    P +P    P+   
Sbjct: 449 EPAP----TTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 504

Query: 472 PSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAP--PALATPPLQ 529
                 P ++ P+ P  P  +P+    P    P AA P    +P P  P  PA  TP   
Sbjct: 505 KPAPTTPEELAPTTPEEP--TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP 562

Query: 530 ALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP------PASPTL 583
           A  +P  + P     +   +L      TP   AP  LA    + P S       P +P  
Sbjct: 563 APTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG 622

Query: 584 QAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELR 643
            AP  P  P P T            P P  P   +P+ TL  P     ++     P+EL 
Sbjct: 623 TAPTTPKEPAPTTPKE---------PAPTTPKGTAPT-TLKEP---APTTPKKPAPKELA 669

Query: 644 GYDS-GPEGGAAASPPPDA--ELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSA 700
              + GP    +  P P    E A   P    + PAP       P  P P  P T P + 
Sbjct: 670 PTTTKGPTSTTSDKPAPTTPKETAPTTP----KEPAPT-----TPKKPAPTTPETPPPTT 720

Query: 701 DGLCTIYETEGPE-------------SATPAPGALDPGP-SPGTSGGKAAA 737
             + T   T+ P              SA P P AL+  P  PG    K  A
Sbjct: 721 SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPA 771



 Score =  150 bits (378), Expect = 6e-36
 Identities = 171/673 (25%), Positives = 240/673 (35%), Gaps = 84/673 (12%)

Query: 71  PESAPRAGPTRSAGTSSRNPASRPPASGRGERAP-PAKNTSPGPVSSPGRASGTT--RPG 127
           P S   A PT  A T+++ PA   P          PA  T   P  +  +++ TT   P 
Sbjct: 189 PTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPA 248

Query: 128 PLGQKGLRISAEE---TVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184
           P   K    + +E   T  +  A   PK  A +      T  P P T   A       A 
Sbjct: 249 PTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT-----TKEPAPTTTKSAPTTPKEPAP 303

Query: 185 TEVGLPRPAPSARPRPPT-EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 243
           T    P P     P P T + P  +       +T EP+P   + P+              
Sbjct: 304 TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP------------- 350

Query: 244 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSP 303
                 ++P +  P+   TP+ PA P+ PK       + P  T P++   PA     S+P
Sbjct: 351 ------TAPKKPAPT---TPKEPA-PTTPKEPAPTTTKEPSPTTPKE---PAPTTTKSAP 397

Query: 304 LATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPS 363
             T  P A   +++ PT P  P  ++       P P  P  P+  P+    P+P  TP  
Sbjct: 398 TTTKEP-APTTTKSAPTTPKEPSPTTTK----EPAPTTPKEPA--PTTPKKPAP-TTPKE 449

Query: 364 QATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATP 423
            A T+   P    T    P+ P  P  T P +  P    P    P +P    P +P   P
Sbjct: 450 PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT--PKKLTPTTPEKLAPTTP-EKP 506

Query: 424 SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA-TPPSQAPPSLAAPPLQVP 482
           +P  P  LA    + P   P +P   AP +P A+ P +P    P +   P+   P    P
Sbjct: 507 APTTPEELAPTTPEEP--TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 564

Query: 483 PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP-GQ 541
            +P  + P +P  T P     P    P + A P   AP     P       P  + P G 
Sbjct: 565 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPA-PKELAPTTTKEPTSTTCDKPAPTTPKGT 623

Query: 542 APFSPSASLPMSPLATPPPQAPPVLAAPLLQVP-PSPPASPTLQAPRRPPTPGPDTSVSG 600
           AP +P    P +P   P P  P   A   L+ P P+ P  P  +      T GP ++ S 
Sbjct: 624 APTTPKEPAPTTP-KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 682

Query: 601 ------PRLTLALAP---GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 651
                 P+ T    P    P  P   +P++  + P      S+ T+T E    + S  E 
Sbjct: 683 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 742

Query: 652 GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETE- 710
               S  P        P A    P         PG P    PA              TE 
Sbjct: 743 TPELSAEPT-------PKALENSPK-------EPGVPTTKTPAATKPEMTTTAKDKTTER 788

Query: 711 ----GPESATPAP 719
                PE+ T AP
Sbjct: 789 DLRTTPETTTAAP 801



 Score =  150 bits (378), Expect = 6e-36
 Identities = 166/658 (25%), Positives = 231/658 (35%), Gaps = 83/658 (12%)

Query: 4   KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63
           K +    G A  TP    P   TP+ P S  P  P TP  ++   +A    ++P      
Sbjct: 200 KAETTTKGPALTTPKEPTP--TTPKEPASTTPKEP-TPTTIK---SAPTTPKEP------ 247

Query: 64  GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGT 123
                T  +SAP   P   A T+++ PA   P         PA  T+  P  +  +++ T
Sbjct: 248 ---APTTTKSAPTT-PKEPAPTTTKEPAPTTPKE-------PAPTTTKEPAPTTTKSAPT 296

Query: 124 TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAA 183
           T   P            T  +  A   PK  A +         PTP TP          A
Sbjct: 297 TPKEPA----------PTTPKKPAPTTPKEPAPTTPKE-----PTPTTPKEPAPTTKEPA 341

Query: 184 GTEVGLPRPAPSARPRP--PTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241
            T    P P    +P P  P E    +    +  +T EPSP   + P+       P +  
Sbjct: 342 PTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK 401

Query: 242 LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 301
             +  T  S+P      +  T + PA  +  +P      +P   TP  K+ AP   P   
Sbjct: 402 EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP--KEPAPTT-PKEP 458

Query: 302 SPLATPSPSAALQSQAPPTLPA-TPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT 360
           +P  T  P+     +  PT P  T  ++       TP  LAP +P  P         P T
Sbjct: 459 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA--------PTT 510

Query: 361 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 420
           P   A T+   PT        P+P     A P     PA   P   AP +P    P +P 
Sbjct: 511 PEELAPTTPEEPTPTTPEE--PAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPK 568

Query: 421 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP-PVSPSATPPSQAPPSLAAP-- 477
            T +P  P   A   L+ P    P  P     +P  +  P S +   P+   P   AP  
Sbjct: 569 ET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT 627

Query: 478 PLQVPPSPPASP-PMSPSATPP-----PQAPPPLAAPPLQLAKPPPQAPPALA------T 525
           P +  P+ P  P P +P  T P     P    P    P +LA    + P +        T
Sbjct: 628 PKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT 687

Query: 526 PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585
            P +  P+ P      AP +P    P +P  TPPP    V      + P +   SP    
Sbjct: 688 TPKETAPTTPKE---PAPTTPKKPAPTTP-ETPPPTTSEVSTPTTTKEPTTIHKSPDEST 743

Query: 586 PRRPPTPGPDTSVSGPRLTLALAPGPP---PPPSRSPSSTLSGPDLAGHSSSATSTPE 640
           P     P P    + P+      PG P    P +  P  T +  D        T TPE
Sbjct: 744 PELSAEPTPKALENSPK-----EPGVPTTKTPAATKPEMTTTAKDKTTERDLRT-TPE 795



 Score =  130 bits (327), Expect = 5e-30
 Identities = 160/660 (24%), Positives = 233/660 (35%), Gaps = 86/660 (13%)

Query: 144 RGKATEAPKRSALS-AGARRDTSGPTPGTPSPAMARRSRAAGT-EVGLPRPAPSARPRPP 201
           R K    PK   +  AG+  D       TP  +  + ++ + + ++   +P       PP
Sbjct: 73  RTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPP 132

Query: 202 TEGPRKSVSSASEHSTT---EPSPAARRRPSAGG-----------GLQRPASRSLSSSAT 247
                K  S      TT   + +    ++ S  G            +++ +++ L+ ++ 
Sbjct: 133 NSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSK 192

Query: 248 PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATP 307
            L+ P    P A  T + PA  +  +P       P   TP  K+  P    + S+P  TP
Sbjct: 193 VLAKPT---PKAETTTKGPALTTPKEPTPTTPKEPASTTP--KEPTPTT--IKSAP-TTP 244

Query: 308 SPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATT 367
              A   +++ PT P  P           P     P+P+ P      P+P  T     TT
Sbjct: 245 KEPAPTTTKSAPTTPKEP----------APTTTKEPAPTTPKE----PAPTTTKEPAPTT 290

Query: 368 SLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLAT----P 423
           +  +PT     +  P+ P  P  T P +  P     P    P  PA     P  T    P
Sbjct: 291 TKSAPTTPKEPA--PTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP 348

Query: 424 SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA-SPPVSPSATPPSQAPPSLAAPPLQVP 482
           +P AP   A    + P    P  P       P+ + P  P+ T    AP +   P     
Sbjct: 349 APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 408

Query: 483 PSPPASP-PMSPSATPPPQAPPPLAAPPLQLAKPPPQAP--PALATP----------PLQ 529
            S P +P   SP+ T  P    P    P    KP P  P  PA  TP          P  
Sbjct: 409 KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 468

Query: 530 ALPSPPASFPGQ--APFSPSASLPMSP--LATPPPQAP----PVLAAPLLQVPPSP---- 577
             P  PA    +  AP +P    P +P  LA   P+ P    P   AP     P+P    
Sbjct: 469 TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 528

Query: 578 ---PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSS 634
              P +P   AP  P  P P T+   P  T    P P  P   +P +T  G         
Sbjct: 529 EPAPTTPKAAAPNTPKEPAP-TTPKEPAPTTPKEPAPTTPKETAP-TTPKGTAPTTLKEP 586

Query: 635 ATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWS-RGPAPPLAFRGAPGAPLPWPP 693
           A +TP++       P+  A  +           PA  + +G AP      AP  P    P
Sbjct: 587 APTTPKK-----PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP 641

Query: 694 ATGPGSADGLCTIYETEGPESATPAPGALDPGPSPG---TSGGKAAAGAGAGASSRSPKQ 750
            T  G+A    T+ E        PAP  L P  + G   T+  K A       +  +PK+
Sbjct: 642 TTPKGTAP--TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE 699



 Score =  101 bits (251), Expect = 3e-21
 Identities = 155/660 (23%), Positives = 222/660 (33%), Gaps = 113/660 (17%)

Query: 13  AARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPE 72
           A  TP   AP       P +P+ P P TP              K  A         T  E
Sbjct: 302 APTTPKKPAPTTPKEPAPTTPKEPTPTTP--------------KEPAPTTKEPAPTTPKE 347

Query: 73  SAPRAGPTRSAGTSSRNPAS---RPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 129
            AP A P + A T+ + PA    + PA    +   P     P P ++    + T  P P 
Sbjct: 348 PAPTA-PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 406

Query: 130 GQKGLRISAEE---TVARGKATEAPKRSALSAGARRDTSGPTPGTPS-PAMARRSRAAGT 185
             K    + +E   T  +  A   PK  A +   +     P P TP  PA       A T
Sbjct: 407 TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKK-----PAPTTPKEPAPTTPKEPAPT 461

Query: 186 EVGLPRPAPSARPRP-----------------------PTEGPRKSVSSASEHSTT---E 219
               P P     P P                       PT   + + ++  E + T   E
Sbjct: 462 TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 521

Query: 220 PSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPS--ARGTPRAPAHPSQPK---- 273
           P+P     P+       P +   ++  TP   PA + P   A  TP+ PA P+ PK    
Sbjct: 522 PTPTTPEEPA-------PTTPKAAAPNTP-KEPAPTTPKEPAPTTPKEPA-PTTPKETAP 572

Query: 274 --PKGLQ--ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSS 329
             PKG     L+ P  T P+K A   L P ++    + +      +    T P TP   +
Sbjct: 573 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 632

Query: 330 LTCQLATPLPLAPPSP--SAPPSLQ----TLPSPPATPPSQATTSLGSPTLQATHSFLPS 383
            T    TP   AP +P  +AP +L+    T P  PA P   A T+   PT   +    P+
Sbjct: 633 PT----TPKEPAPTTPKGTAPTTLKEPAPTTPKKPA-PKELAPTTTKGPTSTTSDKPAPT 687

Query: 384 PPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 443
            P     T P +  PA   P   AP +P   PP +   +          +H      +P 
Sbjct: 688 TPKETAPTTPKE--PAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE 745

Query: 444 PS--PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV--------PPSPPASPPMSP 493
            S  P  +A  + P  P V  + TP +  P        +         P +  A+P M+ 
Sbjct: 746 LSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTK 805

Query: 494 --SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS------ 545
             + T        + A   Q+     Q         L+     P     +   +      
Sbjct: 806 ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMN 865

Query: 546 -------PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPAS-PTLQAPRRPPTPGPDTS 597
                  P      S   TP PQ P    AP        P + P ++ P+  PTP   TS
Sbjct: 866 KPEETAKPKDRATNSKATTPKPQKPT--KAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTS 923



 Score = 30.0 bits (66), Expect = 9.5
 Identities = 40/195 (20%), Positives = 68/195 (34%), Gaps = 23/195 (11%)

Query: 26  TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPT--RSA 83
           +P+ PG P    P          A      + L          T PE+   A      +A
Sbjct: 758 SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLR---------TTPETTTAAPKMTKETA 808

Query: 84  GTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVA 143
            T+ +   S+  A+     +   ++T+P  +++      TT    +      I+  E + 
Sbjct: 809 TTTEKTTESKITATTTQVTSTTTQDTTPFKITT---LKTTTLAPKVTTTKKTITTTEIMN 865

Query: 144 RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 203
           + + T  PK  A ++ A          TP P    ++    T    P+  P  R    T 
Sbjct: 866 KPEETAKPKDRATNSKAT---------TPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTP 916

Query: 204 GPRKSVSSASEHSTT 218
            PRK  S+  E + T
Sbjct: 917 TPRKMTSTMPELNPT 931


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score =  152 bits (383), Expect = 2e-36
 Identities = 189/771 (24%), Positives = 269/771 (34%), Gaps = 102/771 (13%)

Query: 2   DNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAER 61
           DNK+++ K     + P     G            P   T    +V  +      KP+  R
Sbjct: 109 DNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPR 168

Query: 62  AG-GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA 120
                   T  E++       +  T      ++  ++   E+   AK T     +S    
Sbjct: 169 PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDL 228

Query: 121 SGTTR----PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAM 176
           + T++    P P           ET  +G A   PK    +    ++ +  TP  P+P  
Sbjct: 229 APTSKVLAKPTPKA---------ETTTKGPALTTPKEPTPTTP--KEPASTTPKEPTPTT 277

Query: 177 ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQR 236
            + +     E     PAP+     PT  P++   +    +T EP+P   + P A    + 
Sbjct: 278 IKSAPTTPKE-----PAPTTTKSAPTT-PKEPAPT----TTKEPAPTTPKEP-APTTTKE 326

Query: 237 PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296
           PA  +  S+ T    PA + P  +  P  P  P+   PK      P +  P  K+ AP  
Sbjct: 327 PAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 385

Query: 297 GPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPS 356
            P   +P A   P+     +  PT P  P           P     PSP+ P      P+
Sbjct: 386 -PKEPAPTAPKKPAPTTPKEPAPTTPKEP----------APTTTKEPSPTTPKE----PA 430

Query: 357 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT--PPPQAP--PALALPPLQAPPSPP 412
           P  T  +  TT   +PT   +    P  P SP  T  P P  P  PA   P   AP +P 
Sbjct: 431 PTTTKSAPTTTKEPAPTTTKSAPTTPKEP-SPTTTKEPAPTTPKEPAPTTPKKPAPTTPK 489

Query: 413 ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ-APFSPPASPPVSPSATPPSQAP 471
              P     TP   AP          P  P P+ P + AP +P    P +P    P+   
Sbjct: 490 EPAP----TTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 545

Query: 472 PSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAP--PALATPPLQ 529
                 P ++ P+ P  P  +P+    P    P AA P    +P P  P  PA  TP   
Sbjct: 546 KPAPTTPEELAPTTPEEP--TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP 603

Query: 530 ALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP------PASPTL 583
           A  +P  + P     +   +L      TP   AP  LA    + P S       P +P  
Sbjct: 604 APTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG 663

Query: 584 QAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELR 643
            AP  P  P P T            P P  P   +P+ TL  P     ++     P+EL 
Sbjct: 664 TAPTTPKEPAPTTPKE---------PAPTTPKGTAPT-TLKEP---APTTPKKPAPKELA 710

Query: 644 GYDS-GPEGGAAASPPPDA--ELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSA 700
              + GP    +  P P    E A   P    + PAP       P  P P  P T P + 
Sbjct: 711 PTTTKGPTSTTSDKPAPTTPKETAPTTP----KEPAPT-----TPKKPAPTTPETPPPTT 761

Query: 701 DGLCTIYETEGPE-------------SATPAPGALDPGP-SPGTSGGKAAA 737
             + T   T+ P              SA P P AL+  P  PG    K  A
Sbjct: 762 SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPA 812



 Score =  150 bits (378), Expect = 6e-36
 Identities = 171/673 (25%), Positives = 240/673 (35%), Gaps = 84/673 (12%)

Query: 71  PESAPRAGPTRSAGTSSRNPASRPPASGRGERAP-PAKNTSPGPVSSPGRASGTT--RPG 127
           P S   A PT  A T+++ PA   P          PA  T   P  +  +++ TT   P 
Sbjct: 230 PTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPA 289

Query: 128 PLGQKGLRISAEE---TVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184
           P   K    + +E   T  +  A   PK  A +      T  P P T   A       A 
Sbjct: 290 PTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT-----TKEPAPTTTKSAPTTPKEPAP 344

Query: 185 TEVGLPRPAPSARPRPPT-EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 243
           T    P P     P P T + P  +       +T EP+P   + P+              
Sbjct: 345 TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP------------- 391

Query: 244 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSP 303
                 ++P +  P+   TP+ PA P+ PK       + P  T P++   PA     S+P
Sbjct: 392 ------TAPKKPAPT---TPKEPA-PTTPKEPAPTTTKEPSPTTPKE---PAPTTTKSAP 438

Query: 304 LATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPS 363
             T  P A   +++ PT P  P  ++       P P  P  P+  P+    P+P  TP  
Sbjct: 439 TTTKEP-APTTTKSAPTTPKEPSPTTTK----EPAPTTPKEPA--PTTPKKPAP-TTPKE 490

Query: 364 QATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATP 423
            A T+   P    T    P+ P  P  T P +  P    P    P +P    P +P   P
Sbjct: 491 PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT--PKKLTPTTPEKLAPTTP-EKP 547

Query: 424 SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA-TPPSQAPPSLAAPPLQVP 482
           +P  P  LA    + P   P +P   AP +P A+ P +P    P +   P+   P    P
Sbjct: 548 APTTPEELAPTTPEEP--TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 605

Query: 483 PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP-GQ 541
            +P  + P +P  T P     P    P + A P   AP     P       P  + P G 
Sbjct: 606 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPA-PKELAPTTTKEPTSTTCDKPAPTTPKGT 664

Query: 542 APFSPSASLPMSPLATPPPQAPPVLAAPLLQVP-PSPPASPTLQAPRRPPTPGPDTSVSG 600
           AP +P    P +P   P P  P   A   L+ P P+ P  P  +      T GP ++ S 
Sbjct: 665 APTTPKEPAPTTP-KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 723

Query: 601 ------PRLTLALAP---GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 651
                 P+ T    P    P  P   +P++  + P      S+ T+T E    + S  E 
Sbjct: 724 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 783

Query: 652 GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETE- 710
               S  P        P A    P         PG P    PA              TE 
Sbjct: 784 TPELSAEPT-------PKALENSPK-------EPGVPTTKTPAATKPEMTTTAKDKTTER 829

Query: 711 ----GPESATPAP 719
                PE+ T AP
Sbjct: 830 DLRTTPETTTAAP 842



 Score =  150 bits (378), Expect = 6e-36
 Identities = 166/658 (25%), Positives = 231/658 (35%), Gaps = 83/658 (12%)

Query: 4   KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63
           K +    G A  TP    P   TP+ P S  P  P TP  ++   +A    ++P      
Sbjct: 241 KAETTTKGPALTTPKEPTP--TTPKEPASTTPKEP-TPTTIK---SAPTTPKEP------ 288

Query: 64  GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGT 123
                T  +SAP   P   A T+++ PA   P         PA  T+  P  +  +++ T
Sbjct: 289 ---APTTTKSAPTT-PKEPAPTTTKEPAPTTPKE-------PAPTTTKEPAPTTTKSAPT 337

Query: 124 TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAA 183
           T   P            T  +  A   PK  A +         PTP TP          A
Sbjct: 338 TPKEPA----------PTTPKKPAPTTPKEPAPTTPKE-----PTPTTPKEPAPTTKEPA 382

Query: 184 GTEVGLPRPAPSARPRP--PTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241
            T    P P    +P P  P E    +    +  +T EPSP   + P+       P +  
Sbjct: 383 PTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK 442

Query: 242 LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 301
             +  T  S+P      +  T + PA  +  +P      +P   TP  K+ AP   P   
Sbjct: 443 EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP--KEPAPTT-PKEP 499

Query: 302 SPLATPSPSAALQSQAPPTLPA-TPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT 360
           +P  T  P+     +  PT P  T  ++       TP  LAP +P  P         P T
Sbjct: 500 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA--------PTT 551

Query: 361 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 420
           P   A T+   PT        P+P     A P     PA   P   AP +P    P +P 
Sbjct: 552 PEELAPTTPEEPTPTTPEE--PAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPK 609

Query: 421 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP-PVSPSATPPSQAPPSLAAP-- 477
            T +P  P   A   L+ P    P  P     +P  +  P S +   P+   P   AP  
Sbjct: 610 ET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT 668

Query: 478 PLQVPPSPPASP-PMSPSATPP-----PQAPPPLAAPPLQLAKPPPQAPPALA------T 525
           P +  P+ P  P P +P  T P     P    P    P +LA    + P +        T
Sbjct: 669 PKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT 728

Query: 526 PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585
            P +  P+ P      AP +P    P +P  TPPP    V      + P +   SP    
Sbjct: 729 TPKETAPTTPKE---PAPTTPKKPAPTTP-ETPPPTTSEVSTPTTTKEPTTIHKSPDEST 784

Query: 586 PRRPPTPGPDTSVSGPRLTLALAPGPP---PPPSRSPSSTLSGPDLAGHSSSATSTPE 640
           P     P P    + P+      PG P    P +  P  T +  D        T TPE
Sbjct: 785 PELSAEPTPKALENSPK-----EPGVPTTKTPAATKPEMTTTAKDKTTERDLRT-TPE 836



 Score =  130 bits (327), Expect = 5e-30
 Identities = 160/660 (24%), Positives = 233/660 (35%), Gaps = 86/660 (13%)

Query: 144 RGKATEAPKRSALS-AGARRDTSGPTPGTPSPAMARRSRAAGT-EVGLPRPAPSARPRPP 201
           R K    PK   +  AG+  D       TP  +  + ++ + + ++   +P       PP
Sbjct: 114 RTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPP 173

Query: 202 TEGPRKSVSSASEHSTT---EPSPAARRRPSAGG-----------GLQRPASRSLSSSAT 247
                K  S      TT   + +    ++ S  G            +++ +++ L+ ++ 
Sbjct: 174 NSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSK 233

Query: 248 PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATP 307
            L+ P    P A  T + PA  +  +P       P   TP  K+  P    + S+P  TP
Sbjct: 234 VLAKPT---PKAETTTKGPALTTPKEPTPTTPKEPASTTP--KEPTPTT--IKSAP-TTP 285

Query: 308 SPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATT 367
              A   +++ PT P  P           P     P+P+ P      P+P  T     TT
Sbjct: 286 KEPAPTTTKSAPTTPKEP----------APTTTKEPAPTTPKE----PAPTTTKEPAPTT 331

Query: 368 SLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLAT----P 423
           +  +PT     +  P+ P  P  T P +  P     P    P  PA     P  T    P
Sbjct: 332 TKSAPTTPKEPA--PTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP 389

Query: 424 SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA-SPPVSPSATPPSQAPPSLAAPPLQVP 482
           +P AP   A    + P    P  P       P+ + P  P+ T    AP +   P     
Sbjct: 390 APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 449

Query: 483 PSPPASP-PMSPSATPPPQAPPPLAAPPLQLAKPPPQAP--PALATP----------PLQ 529
            S P +P   SP+ T  P    P    P    KP P  P  PA  TP          P  
Sbjct: 450 KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 509

Query: 530 ALPSPPASFPGQ--APFSPSASLPMSP--LATPPPQAP----PVLAAPLLQVPPSP---- 577
             P  PA    +  AP +P    P +P  LA   P+ P    P   AP     P+P    
Sbjct: 510 TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 569

Query: 578 ---PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSS 634
              P +P   AP  P  P P T+   P  T    P P  P   +P +T  G         
Sbjct: 570 EPAPTTPKAAAPNTPKEPAP-TTPKEPAPTTPKEPAPTTPKETAP-TTPKGTAPTTLKEP 627

Query: 635 ATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWS-RGPAPPLAFRGAPGAPLPWPP 693
           A +TP++       P+  A  +           PA  + +G AP      AP  P    P
Sbjct: 628 APTTPKK-----PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP 682

Query: 694 ATGPGSADGLCTIYETEGPESATPAPGALDPGPSPG---TSGGKAAAGAGAGASSRSPKQ 750
            T  G+A    T+ E        PAP  L P  + G   T+  K A       +  +PK+
Sbjct: 683 TTPKGTAP--TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE 740



 Score =  101 bits (251), Expect = 3e-21
 Identities = 155/660 (23%), Positives = 222/660 (33%), Gaps = 113/660 (17%)

Query: 13  AARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPE 72
           A  TP   AP       P +P+ P P TP              K  A         T  E
Sbjct: 343 APTTPKKPAPTTPKEPAPTTPKEPTPTTP--------------KEPAPTTKEPAPTTPKE 388

Query: 73  SAPRAGPTRSAGTSSRNPAS---RPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 129
            AP A P + A T+ + PA    + PA    +   P     P P ++    + T  P P 
Sbjct: 389 PAPTA-PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 447

Query: 130 GQKGLRISAEE---TVARGKATEAPKRSALSAGARRDTSGPTPGTPS-PAMARRSRAAGT 185
             K    + +E   T  +  A   PK  A +   +     P P TP  PA       A T
Sbjct: 448 TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKK-----PAPTTPKEPAPTTPKEPAPT 502

Query: 186 EVGLPRPAPSARPRP-----------------------PTEGPRKSVSSASEHSTT---E 219
               P P     P P                       PT   + + ++  E + T   E
Sbjct: 503 TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 562

Query: 220 PSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPS--ARGTPRAPAHPSQPK---- 273
           P+P     P+       P +   ++  TP   PA + P   A  TP+ PA P+ PK    
Sbjct: 563 PTPTTPEEPA-------PTTPKAAAPNTP-KEPAPTTPKEPAPTTPKEPA-PTTPKETAP 613

Query: 274 --PKGLQ--ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSS 329
             PKG     L+ P  T P+K A   L P ++    + +      +    T P TP   +
Sbjct: 614 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 673

Query: 330 LTCQLATPLPLAPPSP--SAPPSLQ----TLPSPPATPPSQATTSLGSPTLQATHSFLPS 383
            T    TP   AP +P  +AP +L+    T P  PA P   A T+   PT   +    P+
Sbjct: 674 PT----TPKEPAPTTPKGTAPTTLKEPAPTTPKKPA-PKELAPTTTKGPTSTTSDKPAPT 728

Query: 384 PPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 443
            P     T P +  PA   P   AP +P   PP +   +          +H      +P 
Sbjct: 729 TPKETAPTTPKE--PAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE 786

Query: 444 PS--PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV--------PPSPPASPPMSP 493
            S  P  +A  + P  P V  + TP +  P        +         P +  A+P M+ 
Sbjct: 787 LSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTK 846

Query: 494 --SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS------ 545
             + T        + A   Q+     Q         L+     P     +   +      
Sbjct: 847 ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMN 906

Query: 546 -------PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPAS-PTLQAPRRPPTPGPDTS 597
                  P      S   TP PQ P    AP        P + P ++ P+  PTP   TS
Sbjct: 907 KPEETAKPKDRATNSKATTPKPQKPT--KAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTS 964



 Score = 30.0 bits (66), Expect = 9.5
 Identities = 40/195 (20%), Positives = 68/195 (34%), Gaps = 23/195 (11%)

Query: 26  TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPT--RSA 83
           +P+ PG P    P          A      + L          T PE+   A      +A
Sbjct: 799 SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLR---------TTPETTTAAPKMTKETA 849

Query: 84  GTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVA 143
            T+ +   S+  A+     +   ++T+P  +++      TT    +      I+  E + 
Sbjct: 850 TTTEKTTESKITATTTQVTSTTTQDTTPFKITT---LKTTTLAPKVTTTKKTITTTEIMN 906

Query: 144 RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 203
           + + T  PK  A ++ A          TP P    ++    T    P+  P  R    T 
Sbjct: 907 KPEETAKPKDRATNSKAT---------TPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTP 957

Query: 204 GPRKSVSSASEHSTT 218
            PRK  S+  E + T
Sbjct: 958 TPRKMTSTMPELNPT 972


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score =  152 bits (383), Expect = 2e-36
 Identities = 189/771 (24%), Positives = 269/771 (34%), Gaps = 102/771 (13%)

Query: 2   DNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAER 61
           DNK+++ K     + P     G            P   T    +V  +      KP+  R
Sbjct: 161 DNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPR 220

Query: 62  AG-GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA 120
                   T  E++       +  T      ++  ++   E+   AK T     +S    
Sbjct: 221 PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDL 280

Query: 121 SGTTR----PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAM 176
           + T++    P P           ET  +G A   PK    +    ++ +  TP  P+P  
Sbjct: 281 APTSKVLAKPTPKA---------ETTTKGPALTTPKEPTPTTP--KEPASTTPKEPTPTT 329

Query: 177 ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQR 236
            + +     E     PAP+     PT  P++   +    +T EP+P   + P A    + 
Sbjct: 330 IKSAPTTPKE-----PAPTTTKSAPTT-PKEPAPT----TTKEPAPTTPKEP-APTTTKE 378

Query: 237 PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296
           PA  +  S+ T    PA + P  +  P  P  P+   PK      P +  P  K+ AP  
Sbjct: 379 PAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 437

Query: 297 GPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPS 356
            P   +P A   P+     +  PT P  P           P     PSP+ P      P+
Sbjct: 438 -PKEPAPTAPKKPAPTTPKEPAPTTPKEP----------APTTTKEPSPTTPKE----PA 482

Query: 357 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT--PPPQAP--PALALPPLQAPPSPP 412
           P  T  +  TT   +PT   +    P  P SP  T  P P  P  PA   P   AP +P 
Sbjct: 483 PTTTKSAPTTTKEPAPTTTKSAPTTPKEP-SPTTTKEPAPTTPKEPAPTTPKKPAPTTPK 541

Query: 413 ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ-APFSPPASPPVSPSATPPSQAP 471
              P     TP   AP          P  P P+ P + AP +P    P +P    P+   
Sbjct: 542 EPAP----TTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 597

Query: 472 PSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAP--PALATPPLQ 529
                 P ++ P+ P  P  +P+    P    P AA P    +P P  P  PA  TP   
Sbjct: 598 KPAPTTPEELAPTTPEEP--TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP 655

Query: 530 ALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP------PASPTL 583
           A  +P  + P     +   +L      TP   AP  LA    + P S       P +P  
Sbjct: 656 APTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG 715

Query: 584 QAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELR 643
            AP  P  P P T            P P  P   +P+ TL  P     ++     P+EL 
Sbjct: 716 TAPTTPKEPAPTTPKE---------PAPTTPKGTAPT-TLKEP---APTTPKKPAPKELA 762

Query: 644 GYDS-GPEGGAAASPPPDA--ELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSA 700
              + GP    +  P P    E A   P    + PAP       P  P P  P T P + 
Sbjct: 763 PTTTKGPTSTTSDKPAPTTPKETAPTTP----KEPAPT-----TPKKPAPTTPETPPPTT 813

Query: 701 DGLCTIYETEGPE-------------SATPAPGALDPGP-SPGTSGGKAAA 737
             + T   T+ P              SA P P AL+  P  PG    K  A
Sbjct: 814 SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPA 864



 Score =  150 bits (378), Expect = 6e-36
 Identities = 171/673 (25%), Positives = 240/673 (35%), Gaps = 84/673 (12%)

Query: 71  PESAPRAGPTRSAGTSSRNPASRPPASGRGERAP-PAKNTSPGPVSSPGRASGTT--RPG 127
           P S   A PT  A T+++ PA   P          PA  T   P  +  +++ TT   P 
Sbjct: 282 PTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPA 341

Query: 128 PLGQKGLRISAEE---TVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184
           P   K    + +E   T  +  A   PK  A +      T  P P T   A       A 
Sbjct: 342 PTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT-----TKEPAPTTTKSAPTTPKEPAP 396

Query: 185 TEVGLPRPAPSARPRPPT-EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 243
           T    P P     P P T + P  +       +T EP+P   + P+              
Sbjct: 397 TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP------------- 443

Query: 244 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSP 303
                 ++P +  P+   TP+ PA P+ PK       + P  T P++   PA     S+P
Sbjct: 444 ------TAPKKPAPT---TPKEPA-PTTPKEPAPTTTKEPSPTTPKE---PAPTTTKSAP 490

Query: 304 LATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPS 363
             T  P A   +++ PT P  P  ++       P P  P  P+  P+    P+P  TP  
Sbjct: 491 TTTKEP-APTTTKSAPTTPKEPSPTTTK----EPAPTTPKEPA--PTTPKKPAP-TTPKE 542

Query: 364 QATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATP 423
            A T+   P    T    P+ P  P  T P +  P    P    P +P    P +P   P
Sbjct: 543 PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT--PKKLTPTTPEKLAPTTP-EKP 599

Query: 424 SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA-TPPSQAPPSLAAPPLQVP 482
           +P  P  LA    + P   P +P   AP +P A+ P +P    P +   P+   P    P
Sbjct: 600 APTTPEELAPTTPEEP--TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 657

Query: 483 PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP-GQ 541
            +P  + P +P  T P     P    P + A P   AP     P       P  + P G 
Sbjct: 658 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPA-PKELAPTTTKEPTSTTCDKPAPTTPKGT 716

Query: 542 APFSPSASLPMSPLATPPPQAPPVLAAPLLQVP-PSPPASPTLQAPRRPPTPGPDTSVSG 600
           AP +P    P +P   P P  P   A   L+ P P+ P  P  +      T GP ++ S 
Sbjct: 717 APTTPKEPAPTTP-KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 775

Query: 601 ------PRLTLALAP---GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 651
                 P+ T    P    P  P   +P++  + P      S+ T+T E    + S  E 
Sbjct: 776 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 835

Query: 652 GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETE- 710
               S  P        P A    P         PG P    PA              TE 
Sbjct: 836 TPELSAEPT-------PKALENSPK-------EPGVPTTKTPAATKPEMTTTAKDKTTER 881

Query: 711 ----GPESATPAP 719
                PE+ T AP
Sbjct: 882 DLRTTPETTTAAP 894



 Score =  150 bits (378), Expect = 6e-36
 Identities = 166/658 (25%), Positives = 231/658 (35%), Gaps = 83/658 (12%)

Query: 4   KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63
           K +    G A  TP    P   TP+ P S  P  P TP  ++   +A    ++P      
Sbjct: 293 KAETTTKGPALTTPKEPTP--TTPKEPASTTPKEP-TPTTIK---SAPTTPKEP------ 340

Query: 64  GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGT 123
                T  +SAP   P   A T+++ PA   P         PA  T+  P  +  +++ T
Sbjct: 341 ---APTTTKSAPTT-PKEPAPTTTKEPAPTTPKE-------PAPTTTKEPAPTTTKSAPT 389

Query: 124 TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAA 183
           T   P            T  +  A   PK  A +         PTP TP          A
Sbjct: 390 TPKEPA----------PTTPKKPAPTTPKEPAPTTPKE-----PTPTTPKEPAPTTKEPA 434

Query: 184 GTEVGLPRPAPSARPRP--PTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241
            T    P P    +P P  P E    +    +  +T EPSP   + P+       P +  
Sbjct: 435 PTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK 494

Query: 242 LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 301
             +  T  S+P      +  T + PA  +  +P      +P   TP  K+ AP   P   
Sbjct: 495 EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP--KEPAPTT-PKEP 551

Query: 302 SPLATPSPSAALQSQAPPTLPA-TPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT 360
           +P  T  P+     +  PT P  T  ++       TP  LAP +P  P         P T
Sbjct: 552 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA--------PTT 603

Query: 361 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 420
           P   A T+   PT        P+P     A P     PA   P   AP +P    P +P 
Sbjct: 604 PEELAPTTPEEPTPTTPEE--PAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPK 661

Query: 421 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP-PVSPSATPPSQAPPSLAAP-- 477
            T +P  P   A   L+ P    P  P     +P  +  P S +   P+   P   AP  
Sbjct: 662 ET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT 720

Query: 478 PLQVPPSPPASP-PMSPSATPP-----PQAPPPLAAPPLQLAKPPPQAPPALA------T 525
           P +  P+ P  P P +P  T P     P    P    P +LA    + P +        T
Sbjct: 721 PKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT 780

Query: 526 PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585
            P +  P+ P      AP +P    P +P  TPPP    V      + P +   SP    
Sbjct: 781 TPKETAPTTPKE---PAPTTPKKPAPTTP-ETPPPTTSEVSTPTTTKEPTTIHKSPDEST 836

Query: 586 PRRPPTPGPDTSVSGPRLTLALAPGPP---PPPSRSPSSTLSGPDLAGHSSSATSTPE 640
           P     P P    + P+      PG P    P +  P  T +  D        T TPE
Sbjct: 837 PELSAEPTPKALENSPK-----EPGVPTTKTPAATKPEMTTTAKDKTTERDLRT-TPE 888



 Score =  132 bits (332), Expect = 1e-30
 Identities = 177/757 (23%), Positives = 263/757 (34%), Gaps = 109/757 (14%)

Query: 69  TIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPP-------------AKNTSPGPVS 115
           T P S+ +A P   A  + ++   R P     ++                ++N      S
Sbjct: 70  TSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSS 129

Query: 116 SPGRASGTTRPGPLG---------QKGLRISAEETVARGKATEAPKRSALS-AGARRDTS 165
           S   +S T R              QK L++  +    R K    PK   +  AG+  D  
Sbjct: 130 SSSSSSSTIRKIKSSKNSAANRELQKKLKVK-DNKKNRTKKKPTPKPPVVDEAGSGLDNG 188

Query: 166 GPTPGTPSPAMARRSRAAGT-EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTT---EPS 221
                TP  +  + ++ + + ++   +P       PP     K  S      TT   + +
Sbjct: 189 DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKET 248

Query: 222 PAARRRPSAGG-----------GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPS 270
               ++ S  G            +++ +++ L+ ++  L+ P    P A  T + PA  +
Sbjct: 249 TTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT---PKAETTTKGPALTT 305

Query: 271 QPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSL 330
             +P       P   TP  K+  P    + S+P  TP   A   +++ PT P  P     
Sbjct: 306 PKEPTPTTPKEPASTTP--KEPTPTT--IKSAP-TTPKEPAPTTTKSAPTTPKEP----- 355

Query: 331 TCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA 390
                 P     P+P+ P      P+P  T     TT+  +PT     +  P+ P  P  
Sbjct: 356 -----APTTTKEPAPTTPKE----PAPTTTKEPAPTTTKSAPTTPKEPA--PTTPKKPAP 404

Query: 391 TPPPQAPPALALPPLQAPPSPPASPPLSPLAT----PSPQAPNALAVHLLQAPFSPPPSP 446
           T P +  P     P    P  PA     P  T    P+P AP   A    + P    P  
Sbjct: 405 TTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE 464

Query: 447 PVQAPFSPPA-SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP-PMSPSATPPPQAPPP 504
           P       P+ + P  P+ T    AP +   P      S P +P   SP+ T  P    P
Sbjct: 465 PAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTP 524

Query: 505 LAAPPLQLAKPPPQAP--PALATP----------PLQALPSPPASFPGQ--APFSPSASL 550
               P    KP P  P  PA  TP          P    P  PA    +  AP +P    
Sbjct: 525 KEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLT 584

Query: 551 PMSP--LATPPPQAP----PVLAAPLLQVPPSP-------PASPTLQAPRRPPTPGPDTS 597
           P +P  LA   P+ P    P   AP     P+P       P +P   AP  P  P P T+
Sbjct: 585 PTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP-TT 643

Query: 598 VSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASP 657
              P  T    P P  P   +P +T  G         A +TP++       P+  A  + 
Sbjct: 644 PKEPAPTTPKEPAPTTPKETAP-TTPKGTAPTTLKEPAPTTPKK-----PAPKELAPTTT 697

Query: 658 PPDAELAACHPAAWS-RGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESAT 716
                     PA  + +G AP      AP  P    P T  G+A    T+ E        
Sbjct: 698 KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP--TTLKEPAPTTPKK 755

Query: 717 PAPGALDPGPSPG---TSGGKAAAGAGAGASSRSPKQ 750
           PAP  L P  + G   T+  K A       +  +PK+
Sbjct: 756 PAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE 792



 Score =  114 bits (285), Expect = 4e-25
 Identities = 123/555 (22%), Positives = 186/555 (33%), Gaps = 49/555 (8%)

Query: 186 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGL---------QR 236
           EV  P   PS++  PP  G  +++ S ++ S   P+    ++      +         Q 
Sbjct: 65  EVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQE 124

Query: 237 PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296
            +S S SSS++      +S  ++               K  +  + P   PP  D A + 
Sbjct: 125 SSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSG 184

Query: 297 GPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPS 356
                  + TP  S             T H+   T    T      P PS PP+  T   
Sbjct: 185 LDNGDFKVTTPDTS------------TTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKE 232

Query: 357 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPP 416
              T   + T      T     +               +   A     ++   +   +P 
Sbjct: 233 TSLTVNKETTVETKETTTTNKQTSTDG---------KEKTTSAKETQSIEKTSAKDLAPT 283

Query: 417 LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAA 476
              LA P+P+A        L  P  P P+ P +    P ++ P  P+ T    AP +   
Sbjct: 284 SKVLAKPTPKAETTTKGPALTTPKEPTPTTPKE----PASTTPKEPTPTTIKSAPTTPKE 339

Query: 477 PPLQVPPSPPASP-PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPP 535
           P      S P +P   +P+ T  P    P    P    +P P    +  T P +  P+ P
Sbjct: 340 PAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTP 399

Query: 536 ASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP-PASPTLQAPRRPPTPGP 594
                  P  P+ + P  P  T P +  P    P    P  P P +P   AP  P  P P
Sbjct: 400 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAP 459

Query: 595 DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGH-----SSSATSTPEE------LR 643
            T+   P  T    P P  P   +P++T S P          + SA +TP+E        
Sbjct: 460 -TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 518

Query: 644 GYDSGPEGGAAASPPPDAELAACHPAAWS-RGPAPPLAFRGAPGAPLPWPPATGPGSADG 702
              + P+  A  +P   A      PA  + + PAP    + AP  P    P T   +A  
Sbjct: 519 PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT 578

Query: 703 LCTIYETEGPESATP 717
                    PE   P
Sbjct: 579 TPKKLTPTTPEKLAP 593



 Score =  101 bits (251), Expect = 3e-21
 Identities = 155/660 (23%), Positives = 222/660 (33%), Gaps = 113/660 (17%)

Query: 13   AARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPE 72
            A  TP   AP       P +P+ P P TP              K  A         T  E
Sbjct: 395  APTTPKKPAPTTPKEPAPTTPKEPTPTTP--------------KEPAPTTKEPAPTTPKE 440

Query: 73   SAPRAGPTRSAGTSSRNPAS---RPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 129
             AP A P + A T+ + PA    + PA    +   P     P P ++    + T  P P 
Sbjct: 441  PAPTA-PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 499

Query: 130  GQKGLRISAEE---TVARGKATEAPKRSALSAGARRDTSGPTPGTPS-PAMARRSRAAGT 185
              K    + +E   T  +  A   PK  A +   +     P P TP  PA       A T
Sbjct: 500  TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKK-----PAPTTPKEPAPTTPKEPAPT 554

Query: 186  EVGLPRPAPSARPRP-----------------------PTEGPRKSVSSASEHSTT---E 219
                P P     P P                       PT   + + ++  E + T   E
Sbjct: 555  TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 614

Query: 220  PSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPS--ARGTPRAPAHPSQPK---- 273
            P+P     P+       P +   ++  TP   PA + P   A  TP+ PA P+ PK    
Sbjct: 615  PTPTTPEEPA-------PTTPKAAAPNTP-KEPAPTTPKEPAPTTPKEPA-PTTPKETAP 665

Query: 274  --PKGLQ--ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSS 329
              PKG     L+ P  T P+K A   L P ++    + +      +    T P TP   +
Sbjct: 666  TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 725

Query: 330  LTCQLATPLPLAPPSP--SAPPSLQ----TLPSPPATPPSQATTSLGSPTLQATHSFLPS 383
             T    TP   AP +P  +AP +L+    T P  PA P   A T+   PT   +    P+
Sbjct: 726  PT----TPKEPAPTTPKGTAPTTLKEPAPTTPKKPA-PKELAPTTTKGPTSTTSDKPAPT 780

Query: 384  PPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 443
             P     T P +  PA   P   AP +P   PP +   +          +H      +P 
Sbjct: 781  TPKETAPTTPKE--PAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE 838

Query: 444  PS--PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV--------PPSPPASPPMSP 493
             S  P  +A  + P  P V  + TP +  P        +         P +  A+P M+ 
Sbjct: 839  LSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTK 898

Query: 494  --SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS------ 545
              + T        + A   Q+     Q         L+     P     +   +      
Sbjct: 899  ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMN 958

Query: 546  -------PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPAS-PTLQAPRRPPTPGPDTS 597
                   P      S   TP PQ P    AP        P + P ++ P+  PTP   TS
Sbjct: 959  KPEETAKPKDRATNSKATTPKPQKPT--KAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTS 1016



 Score = 30.0 bits (66), Expect = 9.5
 Identities = 40/195 (20%), Positives = 68/195 (34%), Gaps = 23/195 (11%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPT--RSA 83
            +P+ PG P    P          A      + L          T PE+   A      +A
Sbjct: 851  SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLR---------TTPETTTAAPKMTKETA 901

Query: 84   GTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVA 143
             T+ +   S+  A+     +   ++T+P  +++      TT    +      I+  E + 
Sbjct: 902  TTTEKTTESKITATTTQVTSTTTQDTTPFKITT---LKTTTLAPKVTTTKKTITTTEIMN 958

Query: 144  RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 203
            + + T  PK  A ++ A          TP P    ++    T    P+  P  R    T 
Sbjct: 959  KPEETAKPKDRATNSKAT---------TPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTP 1009

Query: 204  GPRKSVSSASEHSTT 218
             PRK  S+  E + T
Sbjct: 1010 TPRKMTSTMPELNPT 1024


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score =  152 bits (383), Expect = 2e-36
 Identities = 189/771 (24%), Positives = 269/771 (34%), Gaps = 102/771 (13%)

Query: 2   DNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAER 61
           DNK+++ K     + P     G            P   T    +V  +      KP+  R
Sbjct: 202 DNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPR 261

Query: 62  AG-GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA 120
                   T  E++       +  T      ++  ++   E+   AK T     +S    
Sbjct: 262 PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDL 321

Query: 121 SGTTR----PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAM 176
           + T++    P P           ET  +G A   PK    +    ++ +  TP  P+P  
Sbjct: 322 APTSKVLAKPTPKA---------ETTTKGPALTTPKEPTPTTP--KEPASTTPKEPTPTT 370

Query: 177 ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQR 236
            + +     E     PAP+     PT  P++   +    +T EP+P   + P A    + 
Sbjct: 371 IKSAPTTPKE-----PAPTTTKSAPTT-PKEPAPT----TTKEPAPTTPKEP-APTTTKE 419

Query: 237 PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296
           PA  +  S+ T    PA + P  +  P  P  P+   PK      P +  P  K+ AP  
Sbjct: 420 PAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 478

Query: 297 GPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPS 356
            P   +P A   P+     +  PT P  P           P     PSP+ P      P+
Sbjct: 479 -PKEPAPTAPKKPAPTTPKEPAPTTPKEP----------APTTTKEPSPTTPKE----PA 523

Query: 357 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT--PPPQAP--PALALPPLQAPPSPP 412
           P  T  +  TT   +PT   +    P  P SP  T  P P  P  PA   P   AP +P 
Sbjct: 524 PTTTKSAPTTTKEPAPTTTKSAPTTPKEP-SPTTTKEPAPTTPKEPAPTTPKKPAPTTPK 582

Query: 413 ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ-APFSPPASPPVSPSATPPSQAP 471
              P     TP   AP          P  P P+ P + AP +P    P +P    P+   
Sbjct: 583 EPAP----TTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 638

Query: 472 PSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAP--PALATPPLQ 529
                 P ++ P+ P  P  +P+    P    P AA P    +P P  P  PA  TP   
Sbjct: 639 KPAPTTPEELAPTTPEEP--TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP 696

Query: 530 ALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP------PASPTL 583
           A  +P  + P     +   +L      TP   AP  LA    + P S       P +P  
Sbjct: 697 APTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG 756

Query: 584 QAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELR 643
            AP  P  P P T            P P  P   +P+ TL  P     ++     P+EL 
Sbjct: 757 TAPTTPKEPAPTTPKE---------PAPTTPKGTAPT-TLKEP---APTTPKKPAPKELA 803

Query: 644 GYDS-GPEGGAAASPPPDA--ELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSA 700
              + GP    +  P P    E A   P    + PAP       P  P P  P T P + 
Sbjct: 804 PTTTKGPTSTTSDKPAPTTPKETAPTTP----KEPAPT-----TPKKPAPTTPETPPPTT 854

Query: 701 DGLCTIYETEGPE-------------SATPAPGALDPGP-SPGTSGGKAAA 737
             + T   T+ P              SA P P AL+  P  PG    K  A
Sbjct: 855 SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPA 905



 Score =  150 bits (378), Expect = 6e-36
 Identities = 171/673 (25%), Positives = 240/673 (35%), Gaps = 84/673 (12%)

Query: 71  PESAPRAGPTRSAGTSSRNPASRPPASGRGERAP-PAKNTSPGPVSSPGRASGTT--RPG 127
           P S   A PT  A T+++ PA   P          PA  T   P  +  +++ TT   P 
Sbjct: 323 PTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPA 382

Query: 128 PLGQKGLRISAEE---TVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184
           P   K    + +E   T  +  A   PK  A +      T  P P T   A       A 
Sbjct: 383 PTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT-----TKEPAPTTTKSAPTTPKEPAP 437

Query: 185 TEVGLPRPAPSARPRPPT-EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 243
           T    P P     P P T + P  +       +T EP+P   + P+              
Sbjct: 438 TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP------------- 484

Query: 244 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSP 303
                 ++P +  P+   TP+ PA P+ PK       + P  T P++   PA     S+P
Sbjct: 485 ------TAPKKPAPT---TPKEPA-PTTPKEPAPTTTKEPSPTTPKE---PAPTTTKSAP 531

Query: 304 LATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPS 363
             T  P A   +++ PT P  P  ++       P P  P  P+  P+    P+P  TP  
Sbjct: 532 TTTKEP-APTTTKSAPTTPKEPSPTTTK----EPAPTTPKEPA--PTTPKKPAP-TTPKE 583

Query: 364 QATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATP 423
            A T+   P    T    P+ P  P  T P +  P    P    P +P    P +P   P
Sbjct: 584 PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT--PKKLTPTTPEKLAPTTP-EKP 640

Query: 424 SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA-TPPSQAPPSLAAPPLQVP 482
           +P  P  LA    + P   P +P   AP +P A+ P +P    P +   P+   P    P
Sbjct: 641 APTTPEELAPTTPEEP--TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 698

Query: 483 PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP-GQ 541
            +P  + P +P  T P     P    P + A P   AP     P       P  + P G 
Sbjct: 699 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPA-PKELAPTTTKEPTSTTCDKPAPTTPKGT 757

Query: 542 APFSPSASLPMSPLATPPPQAPPVLAAPLLQVP-PSPPASPTLQAPRRPPTPGPDTSVSG 600
           AP +P    P +P   P P  P   A   L+ P P+ P  P  +      T GP ++ S 
Sbjct: 758 APTTPKEPAPTTP-KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 816

Query: 601 ------PRLTLALAP---GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 651
                 P+ T    P    P  P   +P++  + P      S+ T+T E    + S  E 
Sbjct: 817 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 876

Query: 652 GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETE- 710
               S  P        P A    P         PG P    PA              TE 
Sbjct: 877 TPELSAEPT-------PKALENSPK-------EPGVPTTKTPAATKPEMTTTAKDKTTER 922

Query: 711 ----GPESATPAP 719
                PE+ T AP
Sbjct: 923 DLRTTPETTTAAP 935



 Score =  150 bits (378), Expect = 6e-36
 Identities = 166/658 (25%), Positives = 231/658 (35%), Gaps = 83/658 (12%)

Query: 4   KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63
           K +    G A  TP    P   TP+ P S  P  P TP  ++   +A    ++P      
Sbjct: 334 KAETTTKGPALTTPKEPTP--TTPKEPASTTPKEP-TPTTIK---SAPTTPKEP------ 381

Query: 64  GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGT 123
                T  +SAP   P   A T+++ PA   P         PA  T+  P  +  +++ T
Sbjct: 382 ---APTTTKSAPTT-PKEPAPTTTKEPAPTTPKE-------PAPTTTKEPAPTTTKSAPT 430

Query: 124 TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAA 183
           T   P            T  +  A   PK  A +         PTP TP          A
Sbjct: 431 TPKEPA----------PTTPKKPAPTTPKEPAPTTPKE-----PTPTTPKEPAPTTKEPA 475

Query: 184 GTEVGLPRPAPSARPRP--PTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241
            T    P P    +P P  P E    +    +  +T EPSP   + P+       P +  
Sbjct: 476 PTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK 535

Query: 242 LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 301
             +  T  S+P      +  T + PA  +  +P      +P   TP  K+ AP   P   
Sbjct: 536 EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP--KEPAPTT-PKEP 592

Query: 302 SPLATPSPSAALQSQAPPTLPA-TPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT 360
           +P  T  P+     +  PT P  T  ++       TP  LAP +P  P         P T
Sbjct: 593 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA--------PTT 644

Query: 361 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 420
           P   A T+   PT        P+P     A P     PA   P   AP +P    P +P 
Sbjct: 645 PEELAPTTPEEPTPTTPEE--PAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPK 702

Query: 421 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP-PVSPSATPPSQAPPSLAAP-- 477
            T +P  P   A   L+ P    P  P     +P  +  P S +   P+   P   AP  
Sbjct: 703 ET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT 761

Query: 478 PLQVPPSPPASP-PMSPSATPP-----PQAPPPLAAPPLQLAKPPPQAPPALA------T 525
           P +  P+ P  P P +P  T P     P    P    P +LA    + P +        T
Sbjct: 762 PKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT 821

Query: 526 PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585
            P +  P+ P      AP +P    P +P  TPPP    V      + P +   SP    
Sbjct: 822 TPKETAPTTPKE---PAPTTPKKPAPTTP-ETPPPTTSEVSTPTTTKEPTTIHKSPDEST 877

Query: 586 PRRPPTPGPDTSVSGPRLTLALAPGPP---PPPSRSPSSTLSGPDLAGHSSSATSTPE 640
           P     P P    + P+      PG P    P +  P  T +  D        T TPE
Sbjct: 878 PELSAEPTPKALENSPK-----EPGVPTTKTPAATKPEMTTTAKDKTTERDLRT-TPE 929



 Score =  132 bits (332), Expect = 1e-30
 Identities = 177/757 (23%), Positives = 263/757 (34%), Gaps = 109/757 (14%)

Query: 69  TIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPP-------------AKNTSPGPVS 115
           T P S+ +A P   A  + ++   R P     ++                ++N      S
Sbjct: 111 TSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSS 170

Query: 116 SPGRASGTTRPGPLG---------QKGLRISAEETVARGKATEAPKRSALS-AGARRDTS 165
           S   +S T R              QK L++  +    R K    PK   +  AG+  D  
Sbjct: 171 SSSSSSSTIRKIKSSKNSAANRELQKKLKVK-DNKKNRTKKKPTPKPPVVDEAGSGLDNG 229

Query: 166 GPTPGTPSPAMARRSRAAGT-EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTT---EPS 221
                TP  +  + ++ + + ++   +P       PP     K  S      TT   + +
Sbjct: 230 DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKET 289

Query: 222 PAARRRPSAGG-----------GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPS 270
               ++ S  G            +++ +++ L+ ++  L+ P    P A  T + PA  +
Sbjct: 290 TTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT---PKAETTTKGPALTT 346

Query: 271 QPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSL 330
             +P       P   TP  K+  P    + S+P  TP   A   +++ PT P  P     
Sbjct: 347 PKEPTPTTPKEPASTTP--KEPTPTT--IKSAP-TTPKEPAPTTTKSAPTTPKEP----- 396

Query: 331 TCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA 390
                 P     P+P+ P      P+P  T     TT+  +PT     +  P+ P  P  
Sbjct: 397 -----APTTTKEPAPTTPKE----PAPTTTKEPAPTTTKSAPTTPKEPA--PTTPKKPAP 445

Query: 391 TPPPQAPPALALPPLQAPPSPPASPPLSPLAT----PSPQAPNALAVHLLQAPFSPPPSP 446
           T P +  P     P    P  PA     P  T    P+P AP   A    + P    P  
Sbjct: 446 TTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE 505

Query: 447 PVQAPFSPPA-SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP-PMSPSATPPPQAPPP 504
           P       P+ + P  P+ T    AP +   P      S P +P   SP+ T  P    P
Sbjct: 506 PAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTP 565

Query: 505 LAAPPLQLAKPPPQAP--PALATP----------PLQALPSPPASFPGQ--APFSPSASL 550
               P    KP P  P  PA  TP          P    P  PA    +  AP +P    
Sbjct: 566 KEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLT 625

Query: 551 PMSP--LATPPPQAP----PVLAAPLLQVPPSP-------PASPTLQAPRRPPTPGPDTS 597
           P +P  LA   P+ P    P   AP     P+P       P +P   AP  P  P P T+
Sbjct: 626 PTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP-TT 684

Query: 598 VSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASP 657
              P  T    P P  P   +P +T  G         A +TP++       P+  A  + 
Sbjct: 685 PKEPAPTTPKEPAPTTPKETAP-TTPKGTAPTTLKEPAPTTPKK-----PAPKELAPTTT 738

Query: 658 PPDAELAACHPAAWS-RGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESAT 716
                     PA  + +G AP      AP  P    P T  G+A    T+ E        
Sbjct: 739 KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP--TTLKEPAPTTPKK 796

Query: 717 PAPGALDPGPSPG---TSGGKAAAGAGAGASSRSPKQ 750
           PAP  L P  + G   T+  K A       +  +PK+
Sbjct: 797 PAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE 833



 Score =  114 bits (285), Expect = 4e-25
 Identities = 123/555 (22%), Positives = 186/555 (33%), Gaps = 49/555 (8%)

Query: 186 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGL---------QR 236
           EV  P   PS++  PP  G  +++ S ++ S   P+    ++      +         Q 
Sbjct: 106 EVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQE 165

Query: 237 PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296
            +S S SSS++      +S  ++               K  +  + P   PP  D A + 
Sbjct: 166 SSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSG 225

Query: 297 GPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPS 356
                  + TP  S             T H+   T    T      P PS PP+  T   
Sbjct: 226 LDNGDFKVTTPDTS------------TTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKE 273

Query: 357 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPP 416
              T   + T      T     +               +   A     ++   +   +P 
Sbjct: 274 TSLTVNKETTVETKETTTTNKQTSTDG---------KEKTTSAKETQSIEKTSAKDLAPT 324

Query: 417 LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAA 476
              LA P+P+A        L  P  P P+ P +    P ++ P  P+ T    AP +   
Sbjct: 325 SKVLAKPTPKAETTTKGPALTTPKEPTPTTPKE----PASTTPKEPTPTTIKSAPTTPKE 380

Query: 477 PPLQVPPSPPASP-PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPP 535
           P      S P +P   +P+ T  P    P    P    +P P    +  T P +  P+ P
Sbjct: 381 PAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTP 440

Query: 536 ASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP-PASPTLQAPRRPPTPGP 594
                  P  P+ + P  P  T P +  P    P    P  P P +P   AP  P  P P
Sbjct: 441 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAP 500

Query: 595 DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGH-----SSSATSTPEE------LR 643
            T+   P  T    P P  P   +P++T S P          + SA +TP+E        
Sbjct: 501 -TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 559

Query: 644 GYDSGPEGGAAASPPPDAELAACHPAAWS-RGPAPPLAFRGAPGAPLPWPPATGPGSADG 702
              + P+  A  +P   A      PA  + + PAP    + AP  P    P T   +A  
Sbjct: 560 PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT 619

Query: 703 LCTIYETEGPESATP 717
                    PE   P
Sbjct: 620 TPKKLTPTTPEKLAP 634



 Score =  101 bits (251), Expect = 3e-21
 Identities = 155/660 (23%), Positives = 222/660 (33%), Gaps = 113/660 (17%)

Query: 13   AARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPE 72
            A  TP   AP       P +P+ P P TP              K  A         T  E
Sbjct: 436  APTTPKKPAPTTPKEPAPTTPKEPTPTTP--------------KEPAPTTKEPAPTTPKE 481

Query: 73   SAPRAGPTRSAGTSSRNPAS---RPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 129
             AP A P + A T+ + PA    + PA    +   P     P P ++    + T  P P 
Sbjct: 482  PAPTA-PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 540

Query: 130  GQKGLRISAEE---TVARGKATEAPKRSALSAGARRDTSGPTPGTPS-PAMARRSRAAGT 185
              K    + +E   T  +  A   PK  A +   +     P P TP  PA       A T
Sbjct: 541  TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKK-----PAPTTPKEPAPTTPKEPAPT 595

Query: 186  EVGLPRPAPSARPRP-----------------------PTEGPRKSVSSASEHSTT---E 219
                P P     P P                       PT   + + ++  E + T   E
Sbjct: 596  TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 655

Query: 220  PSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPS--ARGTPRAPAHPSQPK---- 273
            P+P     P+       P +   ++  TP   PA + P   A  TP+ PA P+ PK    
Sbjct: 656  PTPTTPEEPA-------PTTPKAAAPNTP-KEPAPTTPKEPAPTTPKEPA-PTTPKETAP 706

Query: 274  --PKGLQ--ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSS 329
              PKG     L+ P  T P+K A   L P ++    + +      +    T P TP   +
Sbjct: 707  TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 766

Query: 330  LTCQLATPLPLAPPSP--SAPPSLQ----TLPSPPATPPSQATTSLGSPTLQATHSFLPS 383
             T    TP   AP +P  +AP +L+    T P  PA P   A T+   PT   +    P+
Sbjct: 767  PT----TPKEPAPTTPKGTAPTTLKEPAPTTPKKPA-PKELAPTTTKGPTSTTSDKPAPT 821

Query: 384  PPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 443
             P     T P +  PA   P   AP +P   PP +   +          +H      +P 
Sbjct: 822  TPKETAPTTPKE--PAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE 879

Query: 444  PS--PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV--------PPSPPASPPMSP 493
             S  P  +A  + P  P V  + TP +  P        +         P +  A+P M+ 
Sbjct: 880  LSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTK 939

Query: 494  --SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS------ 545
              + T        + A   Q+     Q         L+     P     +   +      
Sbjct: 940  ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMN 999

Query: 546  -------PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPAS-PTLQAPRRPPTPGPDTS 597
                   P      S   TP PQ P    AP        P + P ++ P+  PTP   TS
Sbjct: 1000 KPEETAKPKDRATNSKATTPKPQKPT--KAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTS 1057



 Score = 30.0 bits (66), Expect = 9.5
 Identities = 40/195 (20%), Positives = 68/195 (34%), Gaps = 23/195 (11%)

Query: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPT--RSA 83
            +P+ PG P    P          A      + L          T PE+   A      +A
Sbjct: 892  SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLR---------TTPETTTAAPKMTKETA 942

Query: 84   GTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVA 143
             T+ +   S+  A+     +   ++T+P  +++      TT    +      I+  E + 
Sbjct: 943  TTTEKTTESKITATTTQVTSTTTQDTTPFKITT---LKTTTLAPKVTTTKKTITTTEIMN 999

Query: 144  RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 203
            + + T  PK  A ++ A          TP P    ++    T    P+  P  R    T 
Sbjct: 1000 KPEETAKPKDRATNSKAT---------TPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTP 1050

Query: 204  GPRKSVSSASEHSTT 218
             PRK  S+  E + T
Sbjct: 1051 TPRKMTSTMPELNPT 1065


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score =  150 bits (380), Expect = 4e-36
 Identities = 188/668 (28%), Positives = 244/668 (36%), Gaps = 99/668 (14%)

Query: 97   SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISA-EETVARGKATEAPKRSA 155
            SG    + P   ++    S  G  S T   G +  + +  S   E   RG   E   ++ 
Sbjct: 536  SGSSSSSIPESQSNHSNQSDSG-VSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKAR 594

Query: 156  LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH 215
            + +  R  TS   P +P P +     A+     LP P P   P PP   P          
Sbjct: 595  MESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPP---------- 644

Query: 216  STTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP-KP 274
                P   ++  PSAG         S   + T L + ++   +    P  P   SQ  KP
Sbjct: 645  --PPPPLPSQSAPSAGSAAPMFVKYS---TITRLQNASQHSGALFKPPTPPVMQSQSVKP 699

Query: 275  KGLQALRPPQ-VTPPRKDAAPALGPLSSSPLATPSPSAAL--QSQAPPTLPATPHSSSLT 331
               Q L PP  V PP     P   P S+     P+P A    Q  APP  P   H     
Sbjct: 700  ---QILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPP-PLKIHQVQHI 755

Query: 332  CQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT 391
             Q+A P P  PP   AP   Q  P P  T P+  +T   +P +        +PP     T
Sbjct: 756  TQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQA-----APP-----T 805

Query: 392  PPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAP--NALAVHLLQAPFSPPPS--PP 447
            P P  PPA   P   A   PP SPP  P+  P P  P   +       +P SP PS    
Sbjct: 806  PTPPVPPAKKQPAFPASYIPP-SPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQ 864

Query: 448  VQAPFSPPASPPVSPS-------ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQ 500
            + + F PP +PP   S       A    Q+PP++ A P   P S P   P  P   PPP+
Sbjct: 865  IASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFP--PPPPE 922

Query: 501  A----PPPLAAPPLQLAKPPPQAPP-ALATPPLQALP--------SPPASFPGQAPFSPS 547
            +    PPP   PP  +  PPP  PP A  TP     P        SP    P   P   S
Sbjct: 923  SSLVFPPP---PPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNS 979

Query: 548  ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASP---TLQAPRRPPTPGPDTSVSGPRLT 604
            +    S    P P+ P V +      PP+   SP   TL  P  PP PG   ++SG  L 
Sbjct: 980  SIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPG-KLNLSGVNLP 1038

Query: 605  LALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELA 664
              L  G           +   P L+G         + +  + S P       PPP+ EL 
Sbjct: 1039 GVLQQG---------CVSAKAPVLSGRGK------DSVVEFPSPPSDSDFPPPPPETELP 1083

Query: 665  ACH---PAAWSRGPAPPLAFRGAPGAPLPW--------PPATGPGSADG--LCTIYETEG 711
                  PA +S   +P +A       P  W        PP T P   D   L     +E 
Sbjct: 1084 LPPIEIPAVFSGNTSPKVAV--VNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQ 1141

Query: 712  PESATPAP 719
            P  AT  P
Sbjct: 1142 PTMATVVP 1149



 Score =  117 bits (293), Expect = 5e-26
 Identities = 166/666 (24%), Positives = 239/666 (35%), Gaps = 94/666 (14%)

Query: 14   ARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRK-------PLAERAGGIG 66
            A  P+   P    P PP  P PPPP  P   +   +AG+              + A    
Sbjct: 621  ASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHS 680

Query: 67   GATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRP 126
            GA      P    ++S       P    P +G     PP     P P  +PG A    +P
Sbjct: 681  GALFKPPTPPVMQSQSV-----KPQILVPPNGVVPPPPP-----PPPPPTPGSAMAQLKP 730

Query: 127  GPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTE 186
             P      + SA            P             + PTP  P P  A     A  +
Sbjct: 731  APCAPSLPQFSA----------PPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPK 780

Query: 187  VGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSA 246
              +  PAP++     T+     V+ A+  + T P P A+++P+       P+  +     
Sbjct: 781  PLVTIPAPTS-----TKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPV 835

Query: 247  TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG-PLSSSPLA 305
             P + P +    A+  P +P  P     K + +  PP  TPP  ++ P    P + +P +
Sbjct: 836  PPPTLPKQQSFCAK-PPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQS 894

Query: 306  TPSPSAALQSQ------APPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPA 359
             P+  A  + Q        P  P  P  SSL      P P+  P P  PP+    P    
Sbjct: 895  PPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSG 954

Query: 360  TP--PSQATTSLGS----PTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPA 413
            +P   +  T+S G     PT Q   S   S   S    P P+ P   +L     PP+   
Sbjct: 955  SPGKKTSKTSSPGGKKPPPTPQRNSSIKSS---SGAEHPEPKRPSVDSLVSKFTPPAESG 1011

Query: 414  SPPLS----PLATPSPQAPNALAVHL----------LQAPFSPP---------PSPPVQA 450
            SP       P A P P   N   V+L           +AP             PSPP  +
Sbjct: 1012 SPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDS 1071

Query: 451  PFSPPASPPVSPSATPPSQAPPSLA---APPLQ-VPPSPPASPPMSPSATPPPQAPPPLA 506
             F PP  PP +    PP + P   +   +P +  V P P     MS    PPP  P    
Sbjct: 1072 DFPPP--PPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRND 1129

Query: 507  APPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPM--------SPLATP 558
            +  L  A+   Q  P +AT   Q   SP +S   Q  F    +  +          L++ 
Sbjct: 1130 STRLTQAEISEQ--PTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSR 1187

Query: 559  PPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRS 618
              +A P      + +PP P   P L + ++    G  + +SG   TL   P PP PP R 
Sbjct: 1188 MSRAEPTATMDDMALPPPP---PELLSDQQKAGYG-GSHISG-YATLRRGP-PPAPPKRD 1241

Query: 619  PSSTLS 624
             ++ LS
Sbjct: 1242 QNTKLS 1247



 Score =  117 bits (293), Expect = 5e-26
 Identities = 115/392 (29%), Positives = 138/392 (35%), Gaps = 68/392 (17%)

Query: 382 PSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS 441
           PSPPL P   PPP  PP    PP   PP PP  PPL   + PS  +   + V        
Sbjct: 624 PSPPLPP---PPPPPPP----PP---PPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRL 673

Query: 442 PPPSPPVQAPFSPPASPPV--SPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP 499
              S    A F PP +PPV  S S  P    PP+   PP   PP PP          P P
Sbjct: 674 QNASQHSGALFKPP-TPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAP 732

Query: 500 QAP--PPLAAPP-----------LQLAKPPPQAPPALATP-PLQALPSPPASFPGQAPFS 545
            AP  P  +APP            Q+A P P  PP +  P P QA P P  + P  AP S
Sbjct: 733 CAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIP--APTS 790

Query: 546 PSASLPMSPLATPPPQAPPVLAAPLLQVPPSP--PASPTLQAPRRPPTPGPDTSVSGPRL 603
                P+   A PP   PPV        PP+   PA P    P  PPTP           
Sbjct: 791 TKTVAPVVTQAAPPTPTPPV--------PPAKKQPAFPASYIPPSPPTP----------- 831

Query: 604 TLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAEL 663
                P P PPP+     +          S   S  +++      P        PP  E 
Sbjct: 832 -----PVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPP------TPPAMES 880

Query: 664 AACHPAAWSRGPAPPLAFRGAP-----GAPLPWPPATGPGSADGLCTIYETEGPESATPA 718
               P   +  P  P A +  P       P+P P    P     L        P  A P 
Sbjct: 881 QPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPP 940

Query: 719 PGALDPGPSPGTSG--GKAAAGAGAGASSRSP 748
           P      P+P  SG  GK  +   +    + P
Sbjct: 941 PPPPTASPTPDKSGSPGKKTSKTSSPGGKKPP 972


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score =  146 bits (368), Expect = 9e-35
 Identities = 166/580 (28%), Positives = 240/580 (41%), Gaps = 92/580 (15%)

Query: 247 TPLSSPARSGPSARGTPRA-------PAHPS----QPKPKGLQALR-PPQVTPPRKDAAP 294
           TP   P     + +G P+        P  P     + KP G   ++  PQ+  P  +  P
Sbjct: 380 TPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEAPLNEEMP 439

Query: 295 ALGPLSSSPLA--------TPSPSAALQSQAPPTLPATPHSSSLTCQLATPL---PLAPP 343
            L P   SPL+        +P P A+  S  P  LPA+P   +L   L+ PL   PL+PP
Sbjct: 440 LLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEAL--HLSRPLEESPLSPP 497

Query: 344 ---SPSAPPSLQTLPSP----PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 396
              SP +PP   +  SP    P +PP ++  S   P L+   S  P P  SPL+ P  ++
Sbjct: 498 PEESPLSPPPESSPFSPLEESPLSPPEESPPS---PALETPLS--PPPEASPLSPPFEES 552

Query: 397 PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPS-----PPV-QA 450
           P  L+ PP + P SPP  P  S L+ P  ++P +      ++P SPPP      PP  ++
Sbjct: 553 P--LSPPPEELPTSPP--PEASRLSPPPEESPMSPPPE--ESPMSPPPEASRLFPPFEES 606

Query: 451 PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL 510
           P SPP  P  SP + PP  +   L+ PP   P SPP  P  SP  +PPP+       P +
Sbjct: 607 PLSPP--PEESPLSPPPEAS--RLSPPPEDSPMSPP--PEESP-MSPPPEVSRLSPLPVV 659

Query: 511 QLAKPPPQAPPALATPPLQALPSPPASFPGQAP---FSPSASLPMSPLATPPPQ----AP 563
               PPP+  P L+ PP ++  SPP      +P    SP++  P    A+PPP+    + 
Sbjct: 660 SRLSPPPEESP-LSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSL 718

Query: 564 PVLAAPLLQVPPSPPASPTLQAPR---RPPTPGPDTSVSGPRLTLA-----LAPGP---- 611
           P+  +PLL +P  P   P  + P    RP  P        P L+       L+P P    
Sbjct: 719 PLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPC 778

Query: 612 ----PPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACH 667
               P  P  SP +   GP L+        +P+    + S        SP P+    +  
Sbjct: 779 LCAVPEEPHLSPQA--EGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQ 836

Query: 668 PAAWSRGPAPPLA-----FRGAPGAPLPWPPATGPGS--ADGLCTIYETEGPESATP--- 717
                  P P  +         P +P P  P   PG   A     ++   G  S +P   
Sbjct: 837 SEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLG 896

Query: 718 APGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELP 757
            P   +PG  P +   +    + +G  S SP+      LP
Sbjct: 897 EPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLP 936



 Score =  145 bits (366), Expect = 2e-34
 Identities = 219/827 (26%), Positives = 285/827 (34%), Gaps = 143/827 (17%)

Query: 7    KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRK---------- 56
            KA+ G   R+ A +   + +   P  P   P   P AL V       G            
Sbjct: 351  KAQGGQTIRSVAEQHTPVCSRFSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPG 410

Query: 57   PLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSS 116
            PL   A  +G A +     +  P   A  +   P   PP        P    TSP P +S
Sbjct: 411  PLQCEAKPLGKAGV-----QLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEAS 465

Query: 117  PGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAM 176
              R S      P       +     +     +  P+ S LS         P P +   + 
Sbjct: 466  --RLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLS---------PPPESSPFSP 514

Query: 177  ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKS-------VSSASEHSTTEPSPAARRRPS 229
               S  +  E   P PA      PP E    S       +S   E   T P P A R   
Sbjct: 515  LEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASR--- 571

Query: 230  AGGGLQRPASRSLSSSATPLSSPARSGPSA-RGTPRAPAHPSQPKPKGLQALRPPQ---V 285
                L  P   S   S  P  SP    P A R  P     P  P P+      PP+   +
Sbjct: 572  ----LSPPPEES-PMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRL 626

Query: 286  TPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPP-- 343
            +PP +D +P   P   SP+ +P P  +  S  P     +P             PL+PP  
Sbjct: 627  SPPPED-SPMSPPPEESPM-SPPPEVSRLSPLPVVSRLSPPPEE--------SPLSPPPE 676

Query: 344  -SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALAL 402
             SP++PP   +  SP   PP  + TS             P P  SP A+PPP+    ++L
Sbjct: 677  ESPTSPPPEASRLSP---PPEDSPTS-------------PPPEDSP-ASPPPE-DSLMSL 718

Query: 403  PPLQAPPSP-PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAP-FSP------ 454
            P  ++P  P P  P L P +     +P     HL   P  P  SP  + P  SP      
Sbjct: 719  PLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPC 778

Query: 455  ----PASPPVSPSATPPSQAP--------PSLAAPPLQVPPSPPASPPMSPSATPPPQAP 502
                P  P +SP A  P  +P        P    P L   P  P   P    +   PQ+ 
Sbjct: 779  LCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSE 838

Query: 503  PPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPP--P 560
             P  +P            P L  PPL   P  P   PGQ P      LP+ P   PP  P
Sbjct: 839  EPCLSP----RPEESHLSPELEKPPLSPRPEKPPEEPGQCP--APEELPLFP---PPGEP 889

Query: 561  QAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPS 620
               P+L  P L  P  PP SP        P   P +    P L+  L P  P PP  SP 
Sbjct: 890  SLSPLLGEPALSEPGEPPLSPL-------PEELPLSPSGEPSLSPQLMPPDPLPPPLSPI 942

Query: 621  STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAA-------SPPPDAELAACHPAAWSR 673
             T + P  A         P   +G DS PE   AA       SPPP+A            
Sbjct: 943  ITAAAPP-ALSPLGELEYPFGAKG-DSDPESPLAAPILETPISPPPEANCT-------DP 993

Query: 674  GPAPPLAFRGAPGAPL---------PWPPATGPGSADGLCTIYETEGPESATPAPGALDP 724
             P PP+    +PG+P+         P PP   P     L  + +   P   +P P     
Sbjct: 994  EPVPPMILPPSPGSPVGPASPILMEPLPPQCSPLLQHSL--VPQNSPPSQCSP-PALPLS 1050

Query: 725  GPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLS 771
             PSP +  GK   G    A     +  ++ E    AL+ S    L S
Sbjct: 1051 VPSPLSPIGK-VVGVSDEAELHEMETEKVSEPECPALEPSATSPLPS 1096



 Score =  139 bits (349), Expect = 1e-32
 Identities = 201/753 (26%), Positives = 257/753 (34%), Gaps = 137/753 (18%)

Query: 25   LTPRPPGSPRPPPP----VTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPT 80
            L+P P  SP  PPP     +P     L         P  E       +  PE++P + P 
Sbjct: 494  LSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPL----SPPPEASPLSPPF 549

Query: 81   RSAGTS---SRNPASRPPASGRGERAPPAKNTSP----GPVSSPGRASGTTRPGPLGQKG 133
              +  S      P S PP + R    P     SP     P+S P  AS    P    +  
Sbjct: 550  EESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPP--FEESP 607

Query: 134  LRISAEETVARGKATEAPKRSALSAGARRDTSGP----TPGTPSPAMARRSRAAGTEVGL 189
            L    EE+      +  P+ S LS         P    +P +P P ++R S         
Sbjct: 608  LSPPPEES----PLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLS--------- 654

Query: 190  PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 249
            P P  S    PP E P   +S   E S T P P A R          P      +S  P 
Sbjct: 655  PLPVVSRLSPPPEESP---LSPPPEESPTSPPPEASRLS--------PPPEDSPTSPPPE 703

Query: 250  SSPARSGP--SARGTP--RAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA 305
             SPA   P  S    P   +P  P   +P+       P ++P  ++  P L P    P  
Sbjct: 704  DSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEE--PHLSPRPEEPHL 761

Query: 306  TPSPSAALQSQAP--PTLPATPHSSSLTCQLATP--------LPLAPPSPSAPPSLQTLP 355
            +P       S  P  P L A P    L+ Q   P        L L+P +    P L  +P
Sbjct: 762  SPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEE--PHLSPVP 819

Query: 356  SPPATPPSQATTSLG--------SPTLQATHSF--LPSPPLSPLATPPPQAPPALALPPL 405
              P   P    + L         SP  + +H    L  PPLSP    PP+ P     P  
Sbjct: 820  EEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEE 879

Query: 406  QAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSP-PVQAPFSPPASPPVSPSA 464
                 PP  P LSPL          L    L  P  PP SP P + P SP   P +SP  
Sbjct: 880  LPLFPPPGEPSLSPL----------LGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQL 929

Query: 465  TPPSQAPPSL------AAPPL----------------QVPPSPPASPPMSPSATPPPQAP 502
             PP   PP L      AAPP                   P SP A+P +    +PPP+A 
Sbjct: 930  MPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEAN 989

Query: 503  -------PPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL 555
                   PP+  PP   +   P +P  +   P Q  P    S   Q       S P  PL
Sbjct: 990  CTDPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPL 1049

Query: 556  ATPPPQAP--PVLA----APLLQVPP---SPPASPTLQAPRRPPTPGPDTSVSGPRLTLA 606
            + P P +P   V+     A L ++     S P  P L+     P P P   +S P     
Sbjct: 1050 SVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSPLPSPMGDLSCP----- 1104

Query: 607  LAPGPPPPPS-----RSPSSTLSGPDLAGHSSSATSTP----EELRGYDSGPEGGAAASP 657
             AP P P           ++ L G D  G       TP     EL+G     +    A  
Sbjct: 1105 -APSPAPALDDFSGLGEDTAPLDGIDAPGSQPEPGQTPGSLASELKGSPVLLDPEELAPV 1163

Query: 658  PPDAELAACHPAAWSRGPAPPLAFRGAPGAPLP 690
             P      C   A    P        AP AP P
Sbjct: 1164 TPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTP 1196



 Score =  116 bits (290), Expect = 1e-25
 Identities = 187/695 (26%), Positives = 243/695 (34%), Gaps = 97/695 (13%)

Query: 222  PAARRRPSAGGGLQRPASRSLSS----SATPLSSPARSGPSARGTPRAPAHPSQPKPKGL 277
            PAA + P         A+  ++     + + ++   + G  AR T R   H   P   G 
Sbjct: 2053 PAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVGDIARKTDRPALHLRIPPQPGA 2112

Query: 278  QALRPPQVTP---------PRKDAAPALGPLSSSPLATPSPSAA--LQSQAPPTLPATPH 326
                PP   P         P   +  A G L     + P P +   L  + PP +PA   
Sbjct: 2113 LGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVP 2172

Query: 327  SSSLTCQLATPLPLAPPSPSAPPSLQTLPSP---PATPPSQATTSL-GSPTLQATHSFLP 382
            S      LA   PL P  P+APP+    PSP   PA PP    +S  G+      H+  P
Sbjct: 2173 SQD-PFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPP 2231

Query: 383  SPPLSPLATPPPQAPPAL-ALPPLQAPPSPPAS--PPLSPLATPSPQAPNALAVHLLQAP 439
              P    +TP P   P   +L  L  P SP         PL +P P   +  A+ + +  
Sbjct: 2232 GTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPFGESRKALEVKKEE 2291

Query: 440  F---SPPPSPPVQAPFSPPAS----------------PPVSPSATPPSQAPPSLAAPPLQ 480
                SP   PP       P+S                 P++P A+      P L   P +
Sbjct: 2292 LGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQVEPQSPGLGLRPQE 2351

Query: 481  VPPSPPA--SPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASF 538
             PP+     SPP  P    P     P A PPL    P PQ P     PP      PP S 
Sbjct: 2352 PPPAQALAPSPPSHPDIFRPGSYTDPYAQPPL---TPRPQPP-----PPESCCALPPRSL 2403

Query: 539  PGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAP---RRPPTPGPD 595
            P   PFS   + P S  ++  P  P  L+A      PS P +P  Q+P    RPP     
Sbjct: 2404 PSD-PFSRVPASPQSQSSSQSPLTPRPLSAEAF--CPS-PVTPRFQSPDPYSRPP----- 2454

Query: 596  TSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAA 655
               S P+     AP   PP  + P        LA  S  A   P  L    +G       
Sbjct: 2455 ---SRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVP 2511

Query: 656  SPPPDAELAACHPAAWSRGPAP-PLAFRGAPGAPLPWPPATGPG--SADGLCTIY---ET 709
            S  P   + +    A+   P+P    F  A G P   PP   PG     G+ + +    T
Sbjct: 2512 SGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPT 2571

Query: 710  EG-PESA--TPAPGALDPGPSP-GTSGGKAAAGAGAG---ASSRSPKQARLGELPL---G 759
             G P+S   T A G   P  SP G S G      G       S  P  A  G LP    G
Sbjct: 2572 LGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPAPDGSLPYLSHG 2631

Query: 760  ALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAEL------GR 813
            A Q S +      T  +   E    G G     AE  G      + LS  EL       R
Sbjct: 2632 ASQRSGI------TSPVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQTELEKQRQRQR 2685

Query: 814  WAELLSPLDESRASI--TSVTSFSPDDVASPQGDW 846
              ELL      R ++     T+ +      P G W
Sbjct: 2686 LRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSW 2720



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 206/809 (25%), Positives = 265/809 (32%), Gaps = 124/809 (15%)

Query: 7    KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE-----R 61
            + K G  AR     A  L  P  PG+   PPP     + +       G    A+      
Sbjct: 2087 QTKVGDIARKTDRPALHLRIPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPP 2146

Query: 62   AGGIGGATIP-ESAPRAGPTRSAGTSSRNPASRPPA---SGRGERAPPAKNTSPGPVSSP 117
            AG + G   P E   +  P   A   S++P    PA     R   APP     P P  +P
Sbjct: 2147 AGSVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAP 2206

Query: 118  GR---ASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSP 174
             +      ++RPG  GQ G       T   G     P            T  P      P
Sbjct: 2207 AQPPMLGASSRPG-AGQPG----EFHTTPPGTPRHQP-----------STPDPFLKPRCP 2250

Query: 175  AMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH-STTEPSPAARRRPSAGGG 233
            ++   +      VG  + +      PP    RK++    E    + PS      P   G 
Sbjct: 2251 SLDNLAVPESPGVGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYG----PPNLGF 2306

Query: 234  LQRPASRSLSSSATPLSSPARSGPSARGTPRAP-AHPSQPKPKGLQALRPPQVTPPRKDA 292
            +  P      SS T L       P     P  P A   +P+  GL  LR PQ  PP +  
Sbjct: 2307 VDSP------SSGTHLGGLELKTPDVFKAPLTPRASQVEPQSPGL-GLR-PQEPPPAQAL 2358

Query: 293  APALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAP-PSPSAPPSL 351
            AP                      +PP+ P      S T   A P PL P P P  P S 
Sbjct: 2359 AP----------------------SPPSHPDIFRPGSYTDPYAQP-PLTPRPQPPPPESC 2395

Query: 352  QTLP--SPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP-PLQAP 408
              LP  S P+ P S+   S  S +  ++ S L   PLS  A  P    P    P P   P
Sbjct: 2396 CALPPRSLPSDPFSRVPASPQSQS--SSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRP 2453

Query: 409  PSPPAS-PPLSPL-ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP 466
            PS P S  P +PL   P PQ P    V       +         P + PA P     A  
Sbjct: 2454 PSRPQSRDPFAPLHKPPRPQPPE---VAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKV 2510

Query: 467  PSQAPPSLAAPP----LQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA--- 519
            PS  PP+    P        PSP       P A   P   PP+  P L    PPP     
Sbjct: 2511 PSGQPPNFVRSPGTGAFVGTPSPMRF--TFPQAVGEPSLKPPVPQPGL----PPPHGINS 2564

Query: 520  ----PPALATPPLQALPSPPASF-PGQAPFSPSA-----SLPMSPLATP---PPQAPPVL 566
                 P L  P          +F P  +P  PS+     S  +SPL  P   PP AP   
Sbjct: 2565 HFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPAPDG- 2623

Query: 567  AAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP 626
            + P L    S  +  T    +R     P T + G  L  A  PG   P     S T    
Sbjct: 2624 SLPYLSHGASQRSGITSPVEKR---EDPGTGM-GSSLATAELPGTQDPGMSGLSQTELEK 2679

Query: 627  DLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPG 686
                         ++++      E   AA+    A  A   P +W   P+ P AF     
Sbjct: 2680 QRQRQRLRELLIRQQIQRNTLRQEKETAAA----AAGAVGPPGSWGAEPSSP-AFEQLSR 2734

Query: 687  APLPWPPATGPGSADGLCTIYETEGP---ESATPAPGALDPGPSPGTS-----GGKAAAG 738
               P+       S  GL    +  GP     + P+   L   P P T        +   G
Sbjct: 2735 GQTPFAGTQDKSSLVGL-PPSKLSGPILGPGSFPSDDRLSRPPPPATPSSMDVNSRQLVG 2793

Query: 739  AGAGASSRSPKQARLGELPLGALQASVVQ 767
                   R+P     G LPL   Q  + Q
Sbjct: 2794 GSQAFYQRAPYP---GSLPLQQQQQQLWQ 2819



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 184/794 (23%), Positives = 262/794 (32%), Gaps = 174/794 (21%)

Query: 11   GAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATI 70
            GA++R P A  PG     PPG+PR  P      L+               R   +    +
Sbjct: 2213 GASSR-PGAGQPGEFHTTPPGTPRHQPSTPDPFLK--------------PRCPSLDNLAV 2257

Query: 71   PESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKN-----TSP-------GPVSSPG 118
            PES P  G     G  +  P   PP  G   +A   K      +SP       G V SP 
Sbjct: 2258 PES-PGVG-----GGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSP- 2310

Query: 119  RASGTTRPG-----------PLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGP 167
             +SGT   G           PL  +  ++  +      +  E P   AL+          
Sbjct: 2311 -SSGTHLGGLELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIF 2369

Query: 168  TPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR 227
             PG+ +   A+       +   P    +  PR     P   V ++ +  ++  SP   R 
Sbjct: 2370 RPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRP 2429

Query: 228  PSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTP 287
             SA      P +    S   P S P  S P +R  P AP H   P+P+      PP+V  
Sbjct: 2430 LSAEAFCPSPVTPRFQSP-DPYSRPP-SRPQSRD-PFAPLH-KPPRPQ------PPEVAF 2479

Query: 288  PRKDAAPALGPLSSSPLATPS-PSAALQSQAPPTLPAT-PHSSSLTCQLATPLPLAPPSP 345
                 A         P A P+ P+  L ++ P   P     S      + TP P+    P
Sbjct: 2480 KAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFP 2539

Query: 346  SA--PPSLQT-LPSPPATPPSQATTSLG-SPTLQ---------ATHSFLPS--------- 383
             A   PSL+  +P P   PP    +  G  PTL          AT +F PS         
Sbjct: 2540 QAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSG 2599

Query: 384  --------PPLSPLATPPPQAPPALALPPLQAPPSPPA--SPPLSPLATPSPQAPNALAV 433
                     PL P +  PP AP   +LP L    S  +  + P+     P     ++LA 
Sbjct: 2600 STGESYGLSPLRPPSVLPPPAPDG-SLPYLSHGASQRSGITSPVEKREDPGTGMGSSLAT 2658

Query: 434  HLLQAPFSPPPSPPVQ---------------------------------APFSPPASPPV 460
              L     P  S   Q                                 A  +    PP 
Sbjct: 2659 AELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPG 2718

Query: 461  SPSATPPSQAPPSLA------------APPLQVPPSPPASPPMSPSATPPPQAPPPLAAP 508
            S  A P S A   L+            +  + +PPS  + P + P + P           
Sbjct: 2719 SWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDD-------- 2770

Query: 509  PLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 568
              +L++PPP A P+      + L     +F  +AP+    SLP+        Q     AA
Sbjct: 2771 --RLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPY--PGSLPLQQQQQQLWQQQQATAA 2826

Query: 569  PLLQVPPSP--PASPTLQAPRR----------PPTPGPDTSVSGP-----------RLTL 605
              ++   S   P++P  +  R+             PGP   V GP            +  
Sbjct: 2827 TSMRFAMSARFPSTPGPELGRQALGSPLAGISTRLPGPGEPVPGPAGPAQFIELRHNVQK 2886

Query: 606  ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAEL-A 664
             L PG  P P + P        ++         PE LRG           S PP  EL  
Sbjct: 2887 GLGPGGTPFPGQGPPQRPRFYPVS--EDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNN 2944

Query: 665  ACHPAAWSRGPAPP 678
            + HP   ++GP  P
Sbjct: 2945 SLHPTPHTKGPTLP 2958



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 138/555 (24%), Positives = 180/555 (32%), Gaps = 85/555 (15%)

Query: 17   PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76
            P +R P     R P +P   PP  P    V   AG+     LA  + G GG      A  
Sbjct: 2449 PYSRPPSRPQSRDPFAPLHKPP-RPQPPEVAFKAGS-----LAHTSLGAGGFPAALPAGP 2502

Query: 77   AGPTRSAGTSSRNPAS-RPPASGRGERAP-PAKNTSPGPVSSPGRASGTTRPGPLGQKGL 134
            AG   +   S + P   R P +G     P P + T P  V  P       +PG     G+
Sbjct: 2503 AGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPHGI 2562

Query: 135  RISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL-PRPA 193
                      GK    P+ +  +          +P  PS      S + G   GL P   
Sbjct: 2563 NSHFGPGPTLGK----PQSTNYTVATGNFHPSGSPLGPS------SGSTGESYGLSPLRP 2612

Query: 194  PSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPA 253
            PS  P P  +G    +S  +   +   SP  +R     G         + SS      P 
Sbjct: 2613 PSVLPPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTG---------MGSSLATAELPG 2663

Query: 254  RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVT--------PPRKDAAPALGPLSSSPLA 305
               P   G  +      + + +  + L   Q+              AA A+GP  S    
Sbjct: 2664 TQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAE 2723

Query: 306  TPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTL--PSPPATPPS 363
              SP+    S+       T   SSL     + L      P + PS   L  P PPATP S
Sbjct: 2724 PSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPATPSS 2783

Query: 364  QATTSL----GSPTLQATHSFLPSPPLSPLATPPPQ--------APPALALPPLQAPPSP 411
                S     GS   QA +   P P   PL     Q        A  ++        PS 
Sbjct: 2784 MDVNSRQLVGGS---QAFYQRAPYPGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPST 2840

Query: 412  PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFS-----------------P 454
            P  P L   A  SP A  +     L  P  P P P   A F                  P
Sbjct: 2841 PG-PELGRQALGSPLAGISTR---LPGPGEPVPGPAGPAQFIELRHNVQKGLGPGGTPFP 2896

Query: 455  PASPPVSPSATPPSQAPPSLAAP----------PLQVPPSPPASPPMSPSATPPPQAPPP 504
               PP  P   P S+ P  LA            P Q P +PPA P ++ S  P P    P
Sbjct: 2897 GQGPPQRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSAPPA-PELNNSLHPTPHTKGP 2955

Query: 505  LAAPPLQLAKPPPQA 519
                 L+L   PP +
Sbjct: 2956 TLPTGLELVNRPPSS 2970



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 148/584 (25%), Positives = 191/584 (32%), Gaps = 130/584 (22%)

Query: 126  PGPLGQKGLRISAEETVA----RGKATEAPKR---SALSAGARRDTSGPTPGTPSPAMAR 178
            PG LG   L    E+         +ATE P       L+ G   ++    PG   P+++ 
Sbjct: 4012 PGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSG 4071

Query: 179  RSRAAGTEVGLPRPAPSA-RPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRP 237
             S+    +   P+P PS+ + +PP   P +     S   T            AGGG    
Sbjct: 4072 DSQLLLVQPQ-PQPQPSSLQLQPPLRLPGQQQQQVSLLHT------------AGGGSHGQ 4118

Query: 238  ASRSLSSSATPLSSPARSGPSARGTPRAPAHPS-----QPKPKGLQALRPPQVTPPRKDA 292
                 SS A+ +             P   A PS     QP       L P Q    R   
Sbjct: 4119 LGSGSSSEASSV-------------PHLLAQPSVSLGDQPGSMTQNLLGPQQPMLER--- 4162

Query: 293  APALGPLSSSPLATPSPSAALQS-QAPPTLPATPHSSSLTCQLATPLPLAPP----SPSA 347
             P        P   P P   LQS Q  P +   P    L  QL   L   P     SP  
Sbjct: 4163 -PMQNNTGPQP---PKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQ 4218

Query: 348  PPSLQTL-------------PSPPATPPSQATTSL-GSPTLQATHSFLPSPPLSPL---- 389
               LQ L              +PP   P   T+ L G    Q      P P   PL    
Sbjct: 4219 QQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELG 4278

Query: 390  ATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ 449
            A P PQ PP L        P+PP +    P+  P         VH      +PPPS P +
Sbjct: 4279 AGPRPQGPPRL--------PAPPGALSTGPVLGP---------VHP-----TPPPSSPQE 4316

Query: 450  APFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP-PMSPSATPPPQAPPPLAAP 508
                 P  P   PS  P SQ P        Q+PP+ P +P P  P+  PPP    P AA 
Sbjct: 4317 -----PKRPSQLPS--PSSQLPTE-----AQLPPTHPGTPKPQGPTLEPPPGRVSPAAA- 4363

Query: 509  PLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 568
                     Q    L +  L     P      Q P   S+ +P           P     
Sbjct: 4364 ---------QLADTLFSKGLGPWDPPDNLAETQKP-EQSSLVPGHLDQVNGQVVPEASQL 4413

Query: 569  PLLQVPPSPPASPTLQAPRR----PPTPGPDTS----VSGPR------LTLALAPGPPPP 614
             + Q P   P +   Q+ +R     P   P TS    ++GPR      L   L       
Sbjct: 4414 SIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQ 4473

Query: 615  PSRSPSSTLSGPDLAGH-SSSATSTPEELRGYDSGPEGGAAASP 657
             S    S     ++ GH  S      ++L+G  S  E  AA  P
Sbjct: 4474 LSTGRGSEGLRAEINGHIDSKLAGLEQKLQGTPSNKEDAAARKP 4517



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 167/690 (24%), Positives = 228/690 (33%), Gaps = 118/690 (17%)

Query: 16   TPAARAP--GLLTPRPPGSPRP------PPP--VTPAALRVLGAAGAVGRKP------LA 59
            +P+++ P    L P  PG+P+P      PPP  V+PAA ++     + G  P      LA
Sbjct: 4325 SPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLA 4384

Query: 60   ERAGGIGGATIPESAPRAG----PTRSAGTSSRNPASRPPASGRGERAPPAKNTSPG-PV 114
            E       + +P    +      P  S  +  + P   P A G    A   K  + G P+
Sbjct: 4385 ETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALG----AQSVKREANGEPI 4440

Query: 115  SSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSG-------- 166
             +PG ++     GP  + G  +   + + R K  +       S G R + +G        
Sbjct: 4441 GAPGTSNHLLLAGPRSEAGHLLL--QKLLRAKNVQLSTGRG-SEGLRAEINGHIDSKLAG 4497

Query: 167  ---PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPA 223
                  GTPS     +  AA  +   P+P    +        RK +        +E    
Sbjct: 4498 LEQKLQGTPS----NKEDAAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVRASEALLK 4553

Query: 224  ARRRPSAGGGLQRPASRSLSSSATPLSS--PARSGPSARGT------PRAPAHPSQPKPK 275
              ++  +   L  PA  +  S   P  S  P       RG       P  P + SQ   K
Sbjct: 4554 QLKQELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPTGPDYYSQLLTK 4613

Query: 276  GLQALRP------PQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSS 329
               +  P      P   PP        G   S  L      AA    +   L  T    S
Sbjct: 4614 NNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERALRDTSEVKS 4673

Query: 330  LTCQLATPLPL----------APPSPSAPPSLQTLPSPPATPPSQATT--SLGSPTL-QA 376
            L    A P P           +     +P S+    SP +    +A     LGS    Q 
Sbjct: 4674 LDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPHLGSGRWEQE 4733

Query: 377  THSFLPSPPLSPLATPP--PQAPPALALPPLQAPPSPPASP-------PLSPLATPSPQA 427
              +  P  PL P A+ P  P   P  AL  L+ P   P +         +S + T S  A
Sbjct: 4734 DRALSPVIPLIPRASIPVFPDTKPYGALG-LEVPGKLPVTTWEKGKGSEVSVMLTVSAAA 4792

Query: 428  PNAL-----AVHLLQAPFSPP------PSPPVQAPFSPPASPPVSPSATP-------PSQ 469
               L     AV  L +   P       P  P +A   P       P           P  
Sbjct: 4793 AKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPDT 4852

Query: 470  APPSLAAPPLQVPPSPPASP--------PMSPSATPPPQAPPPLAAPPL---QLAKPPPQ 518
             P  L      +P     S           SP+  PP Q         L   QL+ PPP+
Sbjct: 4853 GPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPE 4912

Query: 519  APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPP 578
             P    +PP    PSP A  P   P  P   LP  PLA PP  +P  LA+      P P 
Sbjct: 4913 EP----SPP----PSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPR 4964

Query: 579  ASPTLQA-PRRPPTPGPDTSVSGPRLTLAL 607
            A P  +    RPP       V   RL L L
Sbjct: 4965 ARPPEEGEDSRPPRLKKWKGVRWKRLRLLL 4994



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 164/715 (22%), Positives = 226/715 (31%), Gaps = 149/715 (20%)

Query: 27   PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTS 86
            PRP G PR P P  P AL      G V   P             P S+P+  P R +   
Sbjct: 4281 PRPQGPPRLPAP--PGALSTGPVLGPVHPTP-------------PPSSPQE-PKRPSQLP 4324

Query: 87   SRNPASRPPASGRGERAPPAKNTSPGPV--SSPGRAS--GTTRPGPLGQKGLRISAEETV 142
            S  P+S+ P   +     P      GP     PGR S         L  KGL     +  
Sbjct: 4325 S--PSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGL--GPWDPP 4380

Query: 143  ARGKATEAPKRSALSAGARRDTSGP-TPGTPSPAMARRSR----AAGTEV------GLPR 191
                 T+ P++S+L  G     +G   P     ++ +  R    A G +       G P 
Sbjct: 4381 DNLAETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGEPI 4440

Query: 192  PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSS 251
             AP         GPR                          GL+   +  + S    L  
Sbjct: 4441 GAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEGLRAEINGHIDSKLAGLEQ 4500

Query: 252  PARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRK-------DAAPAL-----GPL 299
              +  PS +    A   P  PKPK +Q      V+  +K        A+ AL       L
Sbjct: 4501 KLQGTPSNK-EDAAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQEL 4559

Query: 300  SSSPLATPSPSAALQSQAP-------------------PTLPATP-HSSSLTCQLATPLP 339
            S  PL  P+ +A     AP                     LP  P + S L  +     P
Sbjct: 4560 SLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNP 4619

Query: 340  LAPPS---PSAPPSLQTLPSPPATP-------PSQATTSLGSP-TLQATHSFLPSPPLSP 388
              PPS   P+ PPS+Q       TP       P  A ++  S   L+ T        L+ 
Sbjct: 4620 PTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERALRDTSEVKSLDLLAA 4679

Query: 389  LATPPPQAPPALALPPLQAPPSP----PASPPLSPLATPSPQAPNALAVHLLQAPFSPPP 444
            L TPP      + +   +   SP    PAS P S L   +P+ P+  +    Q   +  P
Sbjct: 4680 LPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPHLGSGRWEQEDRALSP 4739

Query: 445  SPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPP 504
              P+    S P  P   P      + P  L     +       S  ++ SA         
Sbjct: 4740 VIPLIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAAAAKNLNGV 4799

Query: 505  L-AAPPLQLAKPP-------PQAPPALATPPLQALPSPP--------------------- 535
            + A   L   K P       P++P    T P +     P                     
Sbjct: 4800 MVAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQ 4859

Query: 536  --ASFPG-----------------QAPFSPS--------ASLPMSPLATPPPQAPPVLAA 568
              A  PG                  AP  P+        ++L +  L+ PPP+ P    +
Sbjct: 4860 FDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPS 4919

Query: 569  PLLQVPPSPPASPTLQAP----RRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSP 619
            PL   P SPP  P ++ P      PP P P    S P          P P +R P
Sbjct: 4920 PLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPE------SARPKPRARPP 4968



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 102/394 (25%), Positives = 141/394 (35%), Gaps = 53/394 (13%)

Query: 68   ATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSP----GPVSSPGRASGT 123
            AT   S  + GP  + GT+  + A+ P     GE  P     S      P   P  +S  
Sbjct: 4037 ATEGPSTHQGGPL-AIGTTPESMATEP-----GEVKPSLSGDSQLLLVQPQPQPQPSSLQ 4090

Query: 124  TRPGPL---GQKGLRISAEETVARGKATEAPKRSALSAG------ARRDTS-GPTPGTPS 173
             +P PL   GQ+  ++S   T   G   +    S+  A       A+   S G  PG+ +
Sbjct: 4091 LQP-PLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMT 4149

Query: 174  PAMARRSRAAGTEVGLPRPAPS-ARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG 232
              +    +       L RP  +   P+PP  GP              P+    R    G 
Sbjct: 4150 QNLLGPQQPM-----LERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGV 4204

Query: 233  GLQRPASRSLSSS------ATPLSSPARSGPSARGTPRAPAHPSQPKP-KGLQALRPPQV 285
              + P  R LS        A  +    +   + R TP      +Q  P +GL   +P   
Sbjct: 4205 LAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLG 4264

Query: 286  TPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSP 345
              P     P  GPL     A P P      Q PP LPA P +      L+T   L P  P
Sbjct: 4265 GFP----GPQTGPLQELG-AGPRP------QGPPRLPAPPGA------LSTGPVLGPVHP 4307

Query: 346  SAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALA--LP 403
            + PPS    P  P+  PS ++       L  TH   P P    L  PP +  PA A    
Sbjct: 4308 TPPPSSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLAD 4367

Query: 404  PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ 437
             L +    P  PP +   T  P+  + +  HL Q
Sbjct: 4368 TLFSKGLGPWDPPDNLAETQKPEQSSLVPGHLDQ 4401



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 110/431 (25%), Positives = 145/431 (33%), Gaps = 74/431 (17%)

Query: 340  LAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA--- 396
            L P  P+ P  LQ   SP A  P+   T     T+         P +S  AT  P     
Sbjct: 3997 LGPGMPAKP--LQHFSSPGALGPTLLLTGKEQNTVD--------PAVSSEATEGPSTHQG 4046

Query: 397  --------PPALALPPLQAPPSPPASPPLSPLATPSPQA-PNALAVHLLQAPFSPPPSPP 447
                    P ++A  P +  PS      L  L  P PQ  P++L    LQ P   P    
Sbjct: 4047 GPLAIGTTPESMATEPGEVKPSLSGDSQLL-LVQPQPQPQPSSLQ---LQPPLRLPGQQQ 4102

Query: 448  VQAPFSPPASPPV-----SPSATPPSQAPPSLAAPPLQVPPSPPASP-----PMSPSATP 497
             Q      A         S S++  S  P  LA P + +   P +       P  P    
Sbjct: 4103 QQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLER 4162

Query: 498  PPQ----APPPLAAPPLQLAKPPPQAPPALATPPLQA-LPSPPASFPGQAPFSPSASLPM 552
            P Q      PP   P LQ  +  P          L+A L    A  P     SP     +
Sbjct: 4163 PMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQL 4222

Query: 553  SPLA-------------TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVS 599
              L              TPP Q P    +PL  +    P             PGP T   
Sbjct: 4223 QALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGF--------PGPQT--- 4271

Query: 600  GPRLTLALAPGPPPPPS--RSPSSTLSGPDLAG-HSSSATSTPEELRGYDSGPEGGAAAS 656
            GP   L   P P  PP     P +  +GP L   H +   S+P+E +     P    ++ 
Sbjct: 4272 GPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPS--PSSQ 4329

Query: 657  PPPDAELAACHPAAWS-RGPA---PPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGP 712
             P +A+L   HP     +GP    PP     A         + G G  D    + ET+ P
Sbjct: 4330 LPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKP 4389

Query: 713  ESATPAPGALD 723
            E ++  PG LD
Sbjct: 4390 EQSSLVPGHLD 4400



 Score = 37.7 bits (86), Expect = 0.046
 Identities = 73/298 (24%), Positives = 96/298 (32%), Gaps = 51/298 (17%)

Query: 458  PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPP-LQLAKPP 516
            P VS  AT   + P +    PL +  +P +       AT P +  P L+    L L +P 
Sbjct: 4031 PAVSSEAT---EGPSTHQGGPLAIGTTPESM------ATEPGEVKPSLSGDSQLLLVQPQ 4081

Query: 517  PQAPPALATPPLQALPSPPASFPGQAPFSPSASLPM---------SPLATPPPQAPPVLA 567
            PQ  P+     LQ    PP   PGQ     S              S  ++     P +LA
Sbjct: 4082 PQPQPS----SLQL--QPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLA 4135

Query: 568  APLLQVPPSP---------PASPTLQAPRR------PPTPGPDTSVSGPRLTLALAPGPP 612
             P + +   P         P  P L+ P +      PP PGP          + + P   
Sbjct: 4136 QPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVG 4195

Query: 613  PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAA-CHPAAW 671
               ++        P L   S       + L       +  A    PP  E      P   
Sbjct: 4196 QLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQG 4255

Query: 672  SRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPG 729
              G  P L   G PG      P TGP    G       +GP      PGAL  GP  G
Sbjct: 4256 LLGCQPQLG--GFPG------PQTGPLQELGAGP--RPQGPPRLPAPPGALSTGPVLG 4303


>gi|112421108 capicua homolog [Homo sapiens]
          Length = 1608

 Score =  144 bits (364), Expect = 3e-34
 Identities = 220/877 (25%), Positives = 292/877 (33%), Gaps = 203/877 (23%)

Query: 28   RPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSS 87
            RPP  P PP P  P      G   A      +  +     AT           + +G  S
Sbjct: 507  RPPLDPEPPGPPDPPVAFGKGYGSAPSSSASSPASSSASAATSFSLGSGTFKAQESGQGS 566

Query: 88   RNPASRPPASGRGERAPPAKNTSPGPVSS-------PGRASGTTRPGPLGQKGLRISAEE 140
                 RPP  G G  A P+K T   P+         P    G   PGP       + A  
Sbjct: 567  TAGPLRPPPPGAGGPATPSKATRFLPMDPATFRRKRPESVGGLEPPGP------SVIAAP 620

Query: 141  TVARGKATEA----PKRSALSAGARRDTSGPTP----GTPSPAMARRSRAAGTEVGLP-- 190
                G   +     P +     G  R  S P P    G P+  ++R +    T V  P  
Sbjct: 621  PSGGGNILQTLVLPPNKEEQEGGGARVPSAPAPSLAYGAPAAPLSRPAATMVTNVVRPVS 680

Query: 191  -RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 249
              P P A    PT G  ++  + +  + TE    +R    +  G+    S   S++AT  
Sbjct: 681  STPVPIASKPFPTSGRAEASPNDTAGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSP 740

Query: 250  SSPARSGPSARGTPRAPAHPSQ----------PKPKGLQALR---PPQVTPPRKDAAPAL 296
            +    +GP      +APA  +           P P  +Q +    P   T     A    
Sbjct: 741  APHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGAGAGS 800

Query: 297  GPLSSSPLATPSPSAA------------------------LQSQAPPTLPATPHSSSLTC 332
            GP    PL    P A                           + AP T  A P   + T 
Sbjct: 801  GPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTT 860

Query: 333  QLATPLP---------LAPPSPSAP-PSLQTLPSPPATPPSQATTSLGSPTLQATHSFLP 382
             +   LP         LA  +P+   P LQ++PS P  P +Q+ + + +P    +   LP
Sbjct: 861  SIRFTLPPGTSTNGKVLAATAPTPGIPILQSVPSAPP-PKAQSVSPVQAPPPGGSAQLLP 919

Query: 383  SPPLSPLATPPPQA-------PPALALPPLQAP----PSPPAS----------------P 415
               L PLA P           P  L  PP   P      PP+                 P
Sbjct: 920  GKVLVPLAAPSMSVRGGGAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVP 979

Query: 416  PLSPLATPSPQA-------PNALAV--------HLLQAPFSPP----------------- 443
            PLSP   P P +       P++  +        H L    SP                  
Sbjct: 980  PLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPTSSVA 1039

Query: 444  -------PSPPV---------QAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV------ 481
                   PS P          QAP   P    VSP  +P  Q PP+ AAP   V      
Sbjct: 1040 LGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSP--QLPPACAAPGGPVITAFYS 1097

Query: 482  -PPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP-----PQAPPALATPPLQALPSPP 535
              P+P +S P++     P QAPP L         PP     P+ PPA AT    A P+P 
Sbjct: 1098 GSPAPTSSAPLAQ----PSQAPPSLVYTVATSTTPPAATILPKGPPAPAT----ATPAPT 1149

Query: 536  ASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVP----PSPPASPTLQAPRRPPT 591
            + FP     S + SL       P P+AP  + A +  +P     +  +     APR+P  
Sbjct: 1150 SPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFEAGASGRPGPAPRQPLE 1209

Query: 592  PGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 651
            PGP    + P   L   P PP PP    + T +       SS     P E R    GPE 
Sbjct: 1210 PGPVREPTAPESELEGQPTPPAPPPLPETWTPT-----ARSSPPLPPPAEERTSAKGPET 1264

Query: 652  GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEG 711
             A+  P   ++        W R P   L  RG P  P P  PA  P  A G        G
Sbjct: 1265 MASKFPSSSSD--------W-RVPGQGLENRGEP--PTPPSPAPAPAVAPG--------G 1305

Query: 712  PESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSP 748
               ++    A D      T   K AAG G     R P
Sbjct: 1306 SSESSSGRAAGD------TPERKEAAGTGKKVKVRPP 1336



 Score =  139 bits (351), Expect = 9e-33
 Identities = 203/741 (27%), Positives = 270/741 (36%), Gaps = 137/741 (18%)

Query: 11   GAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATI 70
            G  AR P+A AP L    P       P   PAA  V      V   P+   +     +  
Sbjct: 642  GGGARVPSAPAPSLAYGAPAA-----PLSRPAATMVTNVVRPVSSTPVPIASKPFPTSGR 696

Query: 71   PESAPR--AGPTRSAGTSSRNPASRP-PASGRGERAPPAKNTSPGPVSSPGRASGTTRPG 127
             E++P   AG     GT SR P   P   S        A  TSP P    G   GT    
Sbjct: 697  AEASPNDTAGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKA 756

Query: 128  PLGQKGLRIS----------AEETVARGKATEAPKRSALSAGARRDTSGPTP-GTPSP-A 175
            P     L +           A + +A+G A      +   AGA    +GP P G   P A
Sbjct: 757  PATVTNLLVGTPGYGAPAPPAVQFIAQG-APGGGTTAGSGAGAGSGPNGPVPLGILQPGA 815

Query: 176  MARRSRAAGTEVGLP------RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPS 229
            + +       +  LP      + AP+  P P T+    S           P+P    R +
Sbjct: 816  LGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPS----------GPAPTTSIRFT 865

Query: 230  AGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQ-PKPKGLQALRPPQVTPP 288
               G         +++ TP     +S PSA         P Q P P G   L P +V  P
Sbjct: 866  LPPGTSTNGKVLAATAPTPGIPILQSVPSAPPPKAQSVSPVQAPPPGGSAQLLPGKVLVP 925

Query: 289  RKDAAPAL-----GPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPP 343
               AAP++     G     PL +P  S  +Q+ A P         S   QL TP+P++ P
Sbjct: 926  L--AAPSMSVRGGGAGQPLPLVSPPFSVPVQNGAQPP--------SKIIQL-TPVPVSTP 974

Query: 344  SPSAPP-SLQTLPSPPATP-----PSQAT---------------TSLGSPTLQATHSFLP 382
            S   PP S  TLP P + P     PS                  TS  S       S+ P
Sbjct: 975  SGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGP 1034

Query: 383  SPPLSPLATPPPQAPPALALPPL---QAPPSPPASPPLSPLATPSPQAPNALAVHLLQAP 439
            +  ++   T    + PA   P L   QAP   P    +SP+  PSPQ P A A       
Sbjct: 1035 TSSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPV--PSPQLPPACAA------ 1086

Query: 440  FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA--APPLQVPPSP---PASPPMSPS 494
               P  P + A +S   +P  S     PSQAPPSL         PP+    P  PP   +
Sbjct: 1087 ---PGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAATILPKGPPAPAT 1143

Query: 495  ATPPPQAPPP----------LAAPPLQLAKPPPQAPP----ALATPPLQALPSPPASFPG 540
            ATP P +P P          L AP  Q  +P P+AP     A+A+ P+ +  +  +  PG
Sbjct: 1144 ATPAPTSPFPSATAGSMTYSLVAPKAQ--RPSPKAPQKVKAAIASIPVGSFEAGASGRPG 1201

Query: 541  QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPD---TS 597
             AP  P   L   P+  P      +   P    PP  P + T  A   PP P P    TS
Sbjct: 1202 PAPRQP---LEPGPVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLPPPAEERTS 1258

Query: 598  VSGPRLTLALAPG-----------------PPPPPSRSPSSTLS--GPDLAGHSSSATST 638
              GP    +  P                  PP PPS +P+  ++  G   +    +A  T
Sbjct: 1259 AKGPETMASKFPSSSSDWRVPGQGLENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDT 1318

Query: 639  PEELRGYDSGPEGGAAASPPP 659
            PE      +G +      PPP
Sbjct: 1319 PERKEAAGTGKK--VKVRPPP 1337



 Score =  139 bits (349), Expect = 1e-32
 Identities = 214/851 (25%), Positives = 291/851 (34%), Gaps = 159/851 (18%)

Query: 25   LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            L P PPG P PP           G   A      +  +     AT           + +G
Sbjct: 510  LDPEPPGPPDPPVAFGK------GYGSAPSSSASSPASSSASAATSFSLGSGTFKAQESG 563

Query: 85   TSSRNPASRPPASGRGERAPPAKNTSPGPV-------SSPGRASGTTRPGPLGQKGLRIS 137
              S     RPP  G G  A P+K T   P+         P    G   PGP       + 
Sbjct: 564  QGSTAGPLRPPPPGAGGPATPSKATRFLPMDPATFRRKRPESVGGLEPPGP------SVI 617

Query: 138  AEETVARGKATEA----PKRSALSAGARRDTSGPTP----GTPSPAMARRSRAAGTEVGL 189
            A      G   +     P +     G  R  S P P    G P+  ++R +    T V  
Sbjct: 618  AAPPSGGGNILQTLVLPPNKEEQEGGGARVPSAPAPSLAYGAPAAPLSRPAATMVTNVVR 677

Query: 190  P---RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSA 246
            P    P P A    PT G  ++  + +  + TE    +R    +  G+    S   S++A
Sbjct: 678  PVSSTPVPIASKPFPTSGRAEASPNDTAGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAA 737

Query: 247  TPLSSPARSGPSARGTPRAPAHPSQ----------PKPKGLQAL---RPPQVTPPRKDAA 293
            T  +    +GP      +APA  +           P P  +Q +    P   T     A 
Sbjct: 738  TSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGAG 797

Query: 294  PALGPLSSSPLATPSPSAALQ----SQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPP 349
               GP    PL    P A  +    +Q    LP  P            L +AP    AP 
Sbjct: 798  AGSGPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQ----------LQVAPAPAPAPG 847

Query: 350  SLQTLPSPPATPPS-----QATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPP--ALAL 402
            +    PS PA   S        TS     L AT    P+P + P+    P APP  A ++
Sbjct: 848  TKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAAT---APTPGI-PILQSVPSAPPPKAQSV 903

Query: 403  PPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSP 462
             P+QAPP P  S  L P     P A  +++V   +   +  P P V    SPP S PV  
Sbjct: 904  SPVQAPP-PGGSAQLLPGKVLVPLAAPSMSV---RGGGAGQPLPLV----SPPFSVPVQN 955

Query: 463  SATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA---------------- 506
             A PPS+    +   P+ V       PP+SP+  P P + P                   
Sbjct: 956  GAQPPSKI---IQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGG 1012

Query: 507  -APPLQLAKPPPQAPPALATPPLQAL--------PSPPASF-----PGQAPFSPSASLPM 552
             A PL  +    QA    +  P  ++        PS PA        GQAP      + +
Sbjct: 1013 HALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGV 1072

Query: 553  SPLATPPPQAPPVLAA---PLLQVPPSPPASPTLQAPRRPPTPGPD-------TSVSGPR 602
            SP+  P PQ PP  AA   P++    S   +PT  AP   P+  P        TS + P 
Sbjct: 1073 SPV--PSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPA 1130

Query: 603  LTLALAPGPPPPPSRSPSSTLSGPD-LAGHSSSATSTPEELRGYDSGP------------ 649
             T+ L  GPP P + +P+ T   P   AG  + +   P+  R     P            
Sbjct: 1131 ATI-LPKGPPAPATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPV 1189

Query: 650  ---EGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLP------W--------- 691
               E GA+  P P A      P       AP     G P  P P      W         
Sbjct: 1190 GSFEAGASGRPGP-APRQPLEPGPVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPP 1248

Query: 692  --PPATGPGSADG---LCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSR 746
              PPA    SA G   + + + +   +   P  G  + G  P       A     G SS 
Sbjct: 1249 LPPPAEERTSAKGPETMASKFPSSSSDWRVPGQGLENRGEPPTPPSPAPAPAVAPGGSSE 1308

Query: 747  SPKQARLGELP 757
            S      G+ P
Sbjct: 1309 SSSGRAAGDTP 1319



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 213/874 (24%), Positives = 300/874 (34%), Gaps = 186/874 (21%)

Query: 59   AERAGGIGGATIPESA-PRA-----------GPTRSAGTSSRNPASRPPASGRGERAPPA 106
            AER   +GG   P SA PRA           G   S            PAS  G + P  
Sbjct: 338  AERLHTVGG---PGSARPRAFSHSGVHSLDGGEVDSQALQELTQMVSGPASYSGPK-PST 393

Query: 107  KNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSAL---------- 156
            +  +PGP ++PG        G       R S  +  A    T   +R  +          
Sbjct: 394  QYGAPGPFAAPGEGGALAATGRPPLLPTRASRSQRAASEDMTSDEERMVICEEEGDDDVI 453

Query: 157  ------------------SAGARRDTSGPTP----GTPSPAMARRSRAAGTEVGLP-RPA 193
                              +     D+SG  P    G      +   R++ T    P  P 
Sbjct: 454  ADDGFGTTDIDLKCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPE 513

Query: 194  PSARPRPPTEGPR--KSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL-- 249
            P   P PP    +   S  S+S  S    S +A    S G G  +       S+A PL  
Sbjct: 514  PPGPPDPPVAFGKGYGSAPSSSASSPASSSASAATSFSLGSGTFKAQESGQGSTAGPLRP 573

Query: 250  -----SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPP------------------QVT 286
                   PA    + R  P  PA   + +P+ +  L PP                   V 
Sbjct: 574  PPPGAGGPATPSKATRFLPMDPATFRRKRPESVGGLEPPGPSVIAAPPSGGGNILQTLVL 633

Query: 287  PPRKDAAPALGPLSSSPLATPSPSAALQSQAPP-TLPATPHSSSLTCQL-ATPLPLAPPS 344
            PP K+     G    S    P+PS A  + A P + PA    +++   + +TP+P+A  S
Sbjct: 634  PPNKEEQEGGGARVPS---APAPSLAYGAPAAPLSRPAATMVTNVVRPVSSTPVPIA--S 688

Query: 345  PSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH---SFLPSPPLSPLATPPPQAPPALA 401
               P S +   SP  T  ++     GS     +    S + S   S  AT P  AP  +A
Sbjct: 689  KPFPTSGRAEASPNDTAGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSP--APHLVA 746

Query: 402  LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ-------------APFSPPPSPPV 448
             P L      PA+     + TP   AP   AV  +              A     P+ PV
Sbjct: 747  GPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGAGAGSGPNGPV 806

Query: 449  -----------------QAPFSPPASPPVSPSATPPSQAPPSLAAPP----------LQV 481
                             Q  +  P  P     A  P+ AP + AA P            +
Sbjct: 807  PLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTL 866

Query: 482  PPSPPASPPMSPSATPPPQAP----PPLAAPPLQLAKPPPQAPPALATPPLQALPSP--- 534
            PP    +  +  +  P P  P     P A PP   +  P QAPP   +   Q LP     
Sbjct: 867  PPGTSTNGKVLAATAPTPGIPILQSVPSAPPPKAQSVSPVQAPPPGGS--AQLLPGKVLV 924

Query: 535  PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA----PLLQVPPSPPASPT-LQAPRRP 589
            P + P  +     A  P+ PL +PP   P    A     ++Q+ P P ++P+ L  P  P
Sbjct: 925  PLAAPSMSVRGGGAGQPL-PLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSP 983

Query: 590  PT-PGPDTS------VSGPRLTL-------ALAPGPPPPPSRSPSSTLSGPDLA---GHS 632
             T PGP +        S  R+T        AL  G  P  S++ + T  GP  +   G +
Sbjct: 984  ATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPTSSVALGFT 1043

Query: 633  SSATSTP---EELRGYDSGP---EGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPG 686
            S   S P   + L      P    G    SP P  +L    PA  + G     AF     
Sbjct: 1044 SLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLP---PACAAPGGPVITAFYSGSP 1100

Query: 687  APLPWPPATGPGSADG--LCTIYETEGPESAT------PAPGALDPGPS----PGTSGGK 734
            AP    P   P  A    + T+  +  P +AT      PAP    P P+      T+G  
Sbjct: 1101 APTSSAPLAQPSQAPPSLVYTVATSTTPPAATILPKGPPAPATATPAPTSPFPSATAGSM 1160

Query: 735  AAAGAGAGASSRSPK-----QARLGELPLGALQA 763
              +     A   SPK     +A +  +P+G+ +A
Sbjct: 1161 TYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFEA 1194



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 148/571 (25%), Positives = 196/571 (34%), Gaps = 114/571 (19%)

Query: 18   AARAPGLLTPRPPG-SPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76
            A +AP LL P   G SP P P + PA         A G   +     G    T   SAP 
Sbjct: 1059 AGQAP-LLAPGQVGVSPVPSPQLPPAC-------AAPGGPVITAFYSGSPAPT--SSAPL 1108

Query: 77   AGPTRSAGTSSRNPASR--PPASGRGERAPPAKNTS-PGPVSS-PGRASGTTRPGPLGQK 132
            A P+++  +     A+   PPA+    + PPA  T+ P P S  P   +G+     +  K
Sbjct: 1109 AQPSQAPPSLVYTVATSTTPPAATILPKGPPAPATATPAPTSPFPSATAGSMTYSLVAPK 1168

Query: 133  GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP-SPAMARRSRAAGTEV-GLP 190
              R S +       A  +    +  AGA     GP P  P  P   R   A  +E+ G P
Sbjct: 1169 AQRPSPKAPQKVKAAIASIPVGSFEAGAS-GRPGPAPRQPLEPGPVREPTAPESELEGQP 1227

Query: 191  RP----------APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSA-------GGG 233
             P           P+AR  PP   P +  +SA       P   A + PS+       G G
Sbjct: 1228 TPPAPPPLPETWTPTARSSPPLPPPAEERTSAKG-----PETMASKFPSSSSDWRVPGQG 1282

Query: 234  LQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAA 293
            L+         S  P  + A  G S   + RA     + K       +     PP K   
Sbjct: 1283 LENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTPERKEAAGTGKKVKVRPPPLKKTF 1342

Query: 294  PALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTC-------------QLATPLPL 340
             ++     S +      A L    P  +  +P   SL               + +T L  
Sbjct: 1343 DSVDNRVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKKRKNSTDLDS 1402

Query: 341  APPSPSAPPSLQ----TLPSPPATPPS---------------QATTSLGS--------PT 373
            AP  P++P        +  S P TP S               +A   LG          +
Sbjct: 1403 APEDPTSPKRKMRRRSSCSSEPNTPKSAKCEGDIFTFDRTGTEAEDVLGELEYDKVPYSS 1462

Query: 374  LQAT--------------HSFLPSPPLSPLATPPPQAPPALALPP---LQAPPSPPASPP 416
            L+ T              H F PS      AT   QA  A   P    LQ          
Sbjct: 1463 LRRTLDQRRALVMQLFQDHGFFPSAQ----ATAAFQARYADIFPSKVCLQLKIRE-VRQK 1517

Query: 417  LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQ-APPSLA 475
            +   ATP+ Q P A      +AP   PP     A  +P  SP   P  T PS  +  + A
Sbjct: 1518 IMQAATPTEQPPGA------EAPLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQA 1571

Query: 476  APPLQVPPSPPASPPMSP--SATPPPQAPPP 504
            APPL   P PP S P  P     P P  PPP
Sbjct: 1572 APPL---PPPPESGPGQPGWEGAPQPSPPPP 1599



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 164/700 (23%), Positives = 229/700 (32%), Gaps = 117/700 (16%)

Query: 16   TPAARAPGLLTPRPPGSPRPPPPVT-PAALRVL------GAAGAVGRKPLAERAGGIGG- 67
            TP+   P L     PG    P  V  P++ R+       G A  +G  P + +AG +   
Sbjct: 973  TPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSY 1032

Query: 68   ---ATIPESAPRAGPTRSAGTSSRNPASRPPASGRGE---------RAPPAKNTSPGPVS 115
               +++       GP+  A       A + P    G+         + PPA     GPV 
Sbjct: 1033 GPTSSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACAAPGGPVI 1092

Query: 116  SP--GRASGTTRPGPLGQKGLRI-SAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP 172
            +     +   T   PL Q      S   TVA   +T  P  + L  G       P   TP
Sbjct: 1093 TAFYSGSPAPTSSAPLAQPSQAPPSLVYTVAT--STTPPAATILPKGP----PAPATATP 1146

Query: 173  SPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG 232
            +P     S  AG+ +     AP A+ RP  + P+K  ++ +          A  RP    
Sbjct: 1147 APTSPFPSATAGS-MTYSLVAPKAQ-RPSPKAPQKVKAAIASIPVGSFEAGASGRPG--- 1201

Query: 233  GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDA 292
                PA R       P+  P        G P  PA P  P+     A   P + PP ++ 
Sbjct: 1202 ----PAPRQPLEPG-PVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLPPPAEER 1256

Query: 293  APALGP------LSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPS 346
              A GP        SS      P   L+++  P  P +P           P P   P  S
Sbjct: 1257 TSAKGPETMASKFPSSSSDWRVPGQGLENRGEPPTPPSP----------APAPAVAPGGS 1306

Query: 347  APPSLQTLPSPPATPPSQATTSLGS------PTLQATHSFLPSPPLSPLATPPPQAPPAL 400
            +  S         TP  +     G       P L+ T   + +  LS +           
Sbjct: 1307 SESSSGRAAGD--TPERKEAAGTGKKVKVRPPPLKKTFDSVDNRVLSEV-----DFEERF 1359

Query: 401  ALPPLQAPPSPPASPPLSPLATPSPQA-------PNALAVHLLQAPFSPPPSPPVQAPFS 453
            A  P   P     SP L  LAT SP+A           +  L  AP  P          S
Sbjct: 1360 AELPEFRPEEVLPSPTLQSLAT-SPRAILGSYRKKRKNSTDLDSAPEDPTSPKRKMRRRS 1418

Query: 454  PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPL---AAPPL 510
              +S P +P +   ++    +         +      +     P       L    A  +
Sbjct: 1419 SCSSEPNTPKS---AKCEGDIFTFDRTGTEAEDVLGELEYDKVPYSSLRRTLDQRRALVM 1475

Query: 511  QLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL--ATPPPQAPPVLAA 568
            QL +     P A AT   QA  +    FP +             +  A  P + PP   A
Sbjct: 1476 QLFQDHGFFPSAQATAAFQARYAD--IFPSKVCLQLKIREVRQKIMQAATPTEQPPGAEA 1533

Query: 569  PLLQVPPSPPASPTLQAPRRPPTP--GPD-TSVSGPRLTLALAPGPPPPPSRSPSSTLSG 625
            PL    P PP + T  AP   P+P  GPD TS S    T   AP  PPPP   P      
Sbjct: 1534 PL----PVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQAAPPLPPPPESGPGQP--- 1586

Query: 626  PDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAA 665
                              G++  P+    + PPP    AA
Sbjct: 1587 ------------------GWEGAPQ---PSPPPPGPSTAA 1605



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 103/382 (26%), Positives = 135/382 (35%), Gaps = 56/382 (14%)

Query: 445 SPPVQAPFS---PPASPPVSPSATPP-------SQAPPSLAAPPLQVPPSPPASPPMSPS 494
           SP +++ F+   PP  P       PP         AP S A+ P     S   S  +   
Sbjct: 496 SPVIRSSFTHCRPPLDPEPPGPPDPPVAFGKGYGSAPSSSASSPASSSASAATSFSLGSG 555

Query: 495 ATPPPQAPPPLAAPPLQLAKPPPQAP-PALATPPLQALPSPPASFPGQAPFSPSASLPMS 553
                ++     A PL+   PPP A  PA  +   + LP  PA+F  + P S     P  
Sbjct: 556 TFKAQESGQGSTAGPLR--PPPPGAGGPATPSKATRFLPMDPATFRRKRPESVGGLEPPG 613

Query: 554 PLATPPPQAPPVLAAPLLQVPPSPPASPTLQA--PRRPPTPGPDTSVSGPRLTLALAPGP 611
           P       APP     +LQ    PP     +    R P  P P           +LA G 
Sbjct: 614 PSVIA---APPSGGGNILQTLVLPPNKEEQEGGGARVPSAPAP-----------SLAYGA 659

Query: 612 PPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAW 671
           P  P   P++T+    +       +STP  +      P  G A + P D   A       
Sbjct: 660 PAAPLSRPAATM----VTNVVRPVSSTPVPIASKPF-PTSGRAEASPNDTAGARTEMGTG 714

Query: 672 SRGPA-PPLAF------RGAPGAPLPWPP-ATGP-----GSADGLCTIYETEGPESATPA 718
           SR P   PL        + +  A  P P    GP     G A    T      P    PA
Sbjct: 715 SRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPA 774

Query: 719 PGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGAL-------QASVVQHLLS 771
           P A+    + G  GG   AG+GAGA S       LG L  GAL       Q   +   L 
Sbjct: 775 PPAVQ-FIAQGAPGGGTTAGSGAGAGSGPNGPVPLGILQPGALGKAGGITQVQYILPTLP 833

Query: 772 RTLLLAAAEGAAGGS-GGGPGG 792
           + L +A A   A G+    P G
Sbjct: 834 QQLQVAPAPAPAPGTKAAAPSG 855



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 100/432 (23%), Positives = 143/432 (33%), Gaps = 87/432 (20%)

Query: 9    KAGAAART-PAARAPGLLTPRP-----------PGSPRPP-PPVTPAALRVLGAAGAVGR 55
            +AGA+ R  PA R P  L P P            G P PP PP  P        +     
Sbjct: 1193 EAGASGRPGPAPRQP--LEPGPVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLP 1250

Query: 56   KPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVS 115
             P  ER    G  T+    P      S+ +  R P        RGE  P   + +P P  
Sbjct: 1251 PPAEERTSAKGPETMASKFP------SSSSDWRVPGQG--LENRGE-PPTPPSPAPAPAV 1301

Query: 116  SPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSG--------- 166
            +PG +S ++     G    R  A  T  + K    P +    +   R  S          
Sbjct: 1302 APGGSSESSSGRAAGDTPERKEAAGTGKKVKVRPPPLKKTFDSVDNRVLSEVDFEERFAE 1361

Query: 167  -----PTPGTPSPAMARRSRAAGTEVGLPRPAPS------ARPRPPTEGPRKSVSSASEH 215
                 P    PSP +   + +    +G  R          + P  PT  P++ +   S  
Sbjct: 1362 LPEFRPEEVLPSPTLQSLATSPRAILGSYRKKRKNSTDLDSAPEDPTS-PKRKMRRRSSC 1420

Query: 216  STTEPSPAARRRPSAGGGLQRPASRS------LSSSATPLSSPARS-------------- 255
            S+   +P + +         R  + +      L     P SS  R+              
Sbjct: 1421 SSEPNTPKSAKCEGDIFTFDRTGTEAEDVLGELEYDKVPYSSLRRTLDQRRALVMQLFQD 1480

Query: 256  ---GPSARGTPRAPAH-----PS---------QPKPKGLQALRPPQVTPPRKDAAPALGP 298
                PSA+ T    A      PS         + + K +QA  P +  P  +   P   P
Sbjct: 1481 HGFFPSAQATAAFQARYADIFPSKVCLQLKIREVRQKIMQAATPTEQPPGAEAPLPVPPP 1540

Query: 299  LSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPP 358
              ++    P+PS A         P +P S S T Q A PLP  P S    P  +  P P 
Sbjct: 1541 TGTAAAPAPTPSPAGGPD-----PTSPSSDSGTAQAAPPLPPPPESGPGQPGWEGAPQPS 1595

Query: 359  ATPPSQATTSLG 370
              PP  +T + G
Sbjct: 1596 PPPPGPSTAATG 1607



 Score = 37.7 bits (86), Expect = 0.046
 Identities = 41/139 (29%), Positives = 53/139 (38%), Gaps = 13/139 (9%)

Query: 428 PNALAV---HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPS 484
           P ++AV   H L  PF  P  P      S    P   P A+  S+ P   AA   + PP 
Sbjct: 29  PRSVAVFPWHSL-VPFLAPSQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHERPPG 87

Query: 485 PPASP-PMSPSATPPPQAPPPLAAPPLQLAK----PPPQAPPALATPPLQ-ALPSPPASF 538
              S  P  P     P++P P    PL + +    PPP      + PP +  L S   S 
Sbjct: 88  GTGSADPERPPGATCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESD 147

Query: 539 PGQA---PFSPSASLPMSP 554
              A     SP   LP+ P
Sbjct: 148 HDDAFLSIMSPEIQLPLPP 166



 Score = 37.7 bits (86), Expect = 0.046
 Identities = 41/147 (27%), Positives = 63/147 (42%), Gaps = 17/147 (11%)

Query: 358 PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPP--SPPASP 415
           P   PSQ       P++Q + +    P   P+A+   + P   A    + PP  +  A P
Sbjct: 42  PFLAPSQP-----DPSVQPSEA--QQPASHPVASNQSKEPAESAAVAHERPPGGTGSADP 94

Query: 416 PLSPLAT----PSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPV-SPSATPPSQA 470
              P AT    P P  P+ L V  +++   PPP+   +A   PP  P + S + +    A
Sbjct: 95  ERPPGATCPESPGPGPPHPLGV--VESGKGPPPTTEEEAS-GPPGEPRLDSETESDHDDA 151

Query: 471 PPSLAAPPLQVPPSPPASPPMSPSATP 497
             S+ +P +Q+P  P      S SA P
Sbjct: 152 FLSIMSPEIQLPLPPGKRRTQSLSALP 178



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 35/136 (25%), Positives = 46/136 (33%), Gaps = 34/136 (25%)

Query: 269 PSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPP--------- 319
           PSQP P             P +   PA  P++S+    P+ SAA+  + PP         
Sbjct: 46  PSQPDPS----------VQPSEAQQPASHPVASNQSKEPAESAAVAHERPPGGTGSADPE 95

Query: 320 ----------TLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
                       P  PH   +      P P      S PP    L S   +    A  S+
Sbjct: 96  RPPGATCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDDAFLSI 155

Query: 370 GSPTLQATHSFLPSPP 385
            SP +Q     LP PP
Sbjct: 156 MSPEIQ-----LPLPP 166



 Score = 32.0 bits (71), Expect = 2.5
 Identities = 38/156 (24%), Positives = 51/156 (32%), Gaps = 35/156 (22%)

Query: 191 RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLS 250
           +P PS +P    +     V+S       E +  A  RP  G G           SA P  
Sbjct: 48  QPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHERPPGGTG-----------SADPER 96

Query: 251 SPARSGPSARGTPRAPAHPSQPKPKGL--QALRPPQVT------PP---------RKDAA 293
            P  + P + G       P  P P G+      PP  T      PP           D  
Sbjct: 97  PPGATCPESPG-------PGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHD 149

Query: 294 PALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSS 329
            A   + S  +  P P    ++Q+   LP    SSS
Sbjct: 150 DAFLSIMSPEIQLPLPPGKRRTQSLSALPKERDSSS 185



 Score = 30.8 bits (68), Expect = 5.6
 Identities = 21/92 (22%), Positives = 27/92 (29%), Gaps = 7/92 (7%)

Query: 90   PASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATE 149
            P  +PP +      PP   T+  P  +P  A G     P    G       T        
Sbjct: 1524 PTEQPPGAEAPLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSG-------TAQAAPPLP 1576

Query: 150  APKRSALSAGARRDTSGPTPGTPSPAMARRSR 181
             P  S            P+P  P P+ A   R
Sbjct: 1577 PPPESGPGQPGWEGAPQPSPPPPGPSTAATGR 1608



 Score = 30.4 bits (67), Expect = 7.3
 Identities = 39/149 (26%), Positives = 51/149 (34%), Gaps = 24/149 (16%)

Query: 539 PGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPT-PGPDTS 597
           P  AP  P  S+        P +A    + P+       PA     A  RPP   G    
Sbjct: 42  PFLAPSQPDPSVQ-------PSEAQQPASHPVASNQSKEPAESAAVAHERPPGGTGSADP 94

Query: 598 VSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASP 657
              P  T   +PGP PP       +  GP          +T EE     SGP G     P
Sbjct: 95  ERPPGATCPESPGPGPPHPLGVVESGKGP--------PPTTEEEA----SGPPG----EP 138

Query: 658 PPDAELAACHPAAWSRGPAPPLAFRGAPG 686
             D+E  + H  A+    +P +     PG
Sbjct: 139 RLDSETESDHDDAFLSIMSPEIQLPLPPG 167


>gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]
          Length = 1003

 Score =  141 bits (356), Expect = 2e-33
 Identities = 230/836 (27%), Positives = 289/836 (34%), Gaps = 178/836 (21%)

Query: 35  PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATI--------PESAPRAG--PTRSAG 84
           P  PVTP    V  A+     K    R   +  AT+          S+P  G  P     
Sbjct: 78  PLAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHT 137

Query: 85  TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL--GQKGLRISAEETV 142
            S   P++RPP      R PP    + GP S P      ++  P   G  GL        
Sbjct: 138 VSPGPPSARPPC-----RVPPTTPLNGGPGSLPPEPPSVSQAFPTLAGPGGL-------F 185

Query: 143 ARGKATEAPKRSALSAGARRDTSGPTPGTPSP------------AMARRSRAAGTEVGLP 190
               A   P   + S       + P+P  P P              A RS    +++G P
Sbjct: 186 PPRLADPVPSGGSSSPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSLVPSDLGSP 245

Query: 191 RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLS 250
            PAP A   PP++ P   +   S+  T  P P +   P+  G   +P   S +     + 
Sbjct: 246 -PAPHASSSPPSDPP---LFHCSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLPLVL 301

Query: 251 SPARSGPSARGTPRAPA--------------HPSQPKPKGLQALRPPQVTPPRKDAAPAL 296
            P    P+  G P AP               HP  P P  LQ  RP +   P    + +L
Sbjct: 302 GPLGGAPTVEG-PGAPPFLASSLLSAAAKAQHPPLPPPSTLQGRRP-RAQAPSASHSSSL 359

Query: 297 GPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAP--PSLQTL 354
            P    P   P+    L+ + P T    P  S        P P + P PS P  PS+ +L
Sbjct: 360 RPSQRRPRRPPTVFRLLEGRGPQT----PRRSRPRAPAPVPQPFSLPEPSQPILPSVLSL 415

Query: 355 PSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP-PQAPPALALP-----PLQAP 408
              P   PS +    GS  L  + + LP PP     +PP P+ P   +LP      L + 
Sbjct: 416 LGLPTPGPSHSD---GSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGSLSSV 472

Query: 409 PSPPASP----------------------------PLSPLAT------PSPQAPNALA-- 432
           P  PA P                            PL PLA       PSP+   AL+  
Sbjct: 473 PGAPAPPAASKAPVVPSPVLQSPSEGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGA 532

Query: 433 -----VHLLQAPFS---PPPSP----------------PVQAPFSPPASPPVSPSATPPS 468
                +  L  P S   PPPSP                P   P  PP   P  P A    
Sbjct: 533 GFPGMLGALPLPLSLGQPPPSPLLNHSLFGVLTGGGGQPPPEPLLPPPGGPGPPLAPGEP 592

Query: 469 QAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPP-LAAPPLQLAKPPPQAPPALATPP 527
           + P  L A  L  PPS            PPP APP  L A  L L    P A     +  
Sbjct: 593 EGPSLLVASLLPPPPSDLL---------PPPSAPPSNLLASFLPLLALGPTAGDGEGS-- 641

Query: 528 LQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA---PLLQV---PPS--PPA 579
                +  A  P   PFS    L  SPL  PP  APP L A    LL     PPS  PP 
Sbjct: 642 -----AEGAGGPSGEPFSGLGDL--SPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQ 694

Query: 580 SPTLQAPR-RPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLS---GPDLAGHSSSA 635
              L AP+  PPT    T+ + P    A + G  P  S  P   LS   G  L G  SS 
Sbjct: 695 PCVLSAPQPGPPTSSVTTATTDPG---ASSLGKAPSNSGRPPQLLSPLLGASLLGDLSSL 751

Query: 636 TSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPAT 695
           TS+P  L      P  G   S     +L          G  PPL+   +P A L      
Sbjct: 752 TSSPGALPSLLQPP--GPLLSGQLGLQLLP------GGGAPPPLSEASSPLACLLQSLQI 803

Query: 696 GPGSADGLCTIYETEG----PESATPAPGAL-DPGPSPGTSGGKAAAGAGAGASSR 746
            P   +  C   E+      PE A P   AL  P  SP     +   G G+G   R
Sbjct: 804 PPEQPEAPCLPPESPASALEPEPARPPLSALAPPHGSPDPPVPELLTGRGSGKRGR 859



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 143/546 (26%), Positives = 178/546 (32%), Gaps = 124/546 (22%)

Query: 17  PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76
           P A AP    P+P   P P  P+ P+ L +LG                          P 
Sbjct: 389 PRAPAP---VPQPFSLPEPSQPILPSVLSLLG-------------------------LPT 420

Query: 77  AGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRI 136
            GP+ S G+ +          G     PP    S G    P      + PG         
Sbjct: 421 PGPSHSDGSFN--------LLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPG--------- 463

Query: 137 SAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAP-- 194
                   G  +  P   A  A ++       P  PSP +   S   G   G   P P  
Sbjct: 464 -----TTSGSLSSVPGAPAPPAASK------APVVPSPVLQSPSEGLGMGAGPACPLPPL 512

Query: 195 ---SARPRP-PTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS-SSATPL 249
               A P P P +G   S +         P P +  +P     L       L+     P 
Sbjct: 513 AGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPLLNHSLFGVLTGGGGQPP 572

Query: 250 SSPARSGPSARGTPRAPAHPSQPK-------PKGLQALRPPQVTPPRKDAAP-----ALG 297
             P    P   G P AP  P  P        P     L PP   PP    A      ALG
Sbjct: 573 PEPLLPPPGGPGPPLAPGEPEGPSLLVASLLPPPPSDLLPPPSAPPSNLLASFLPLLALG 632

Query: 298 PLSS-----------------SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPL 340
           P +                  S L   SP       APPTL A   +S+L      P   
Sbjct: 633 PTAGDGEGSAEGAGGPSGEPFSGLGDLSPLLFPPLSAPPTLIAL--NSALLAATLDPPSG 690

Query: 341 APPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP--LSPLATPPPQAPP 398
            PP P    + Q  P PP +  + ATT  G+ +L    S    PP  LSPL         
Sbjct: 691 TPPQPCVLSAPQ--PGPPTSSVTTATTDPGASSLGKAPSNSGRPPQLLSPLL-------G 741

Query: 399 ALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP 458
           A  L  L +  S P + P S L  P P     L + LL    +P               P
Sbjct: 742 ASLLGDLSSLTSSPGALP-SLLQPPGPLLSGQLGLQLLPGGGAP---------------P 785

Query: 459 PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP-SATPPPQAPPPLAAPPLQLAKPPP 517
           P+S +++P +    SL  PP Q  P  P  PP SP SA  P  A PPL+A       P P
Sbjct: 786 PLSEASSPLACLLQSLQIPPEQ--PEAPCLPPESPASALEPEPARPPLSALAPPHGSPDP 843

Query: 518 QAPPAL 523
             P  L
Sbjct: 844 PVPELL 849



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 74/274 (27%), Positives = 99/274 (36%), Gaps = 58/274 (21%)

Query: 21  APGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG----GATIPESAPR 76
           +PG L    P   +PP P+    L +    G     PL+E +  +        IP   P 
Sbjct: 754 SPGAL----PSLLQPPGPLLSGQLGLQLLPGGGAPPPLSEASSPLACLLQSLQIPPEQPE 809

Query: 77  AG--PTRSAGTSSRNPASRPPASGRGERAPPAKNTSPG-PVSSPGRASGTTRPGPLGQKG 133
           A   P  S  ++     +RPP S     APP  +  P  P    GR SG  + G  G  G
Sbjct: 810 APCLPPESPASALEPEPARPPLSAL---APPHGSPDPPVPELLTGRGSG--KRGRRGGGG 864

Query: 134 LR-ISAEETVARGK---ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL 189
           LR I+ E   ARG+   +   P R AL  G R   +G    +P      +      E G 
Sbjct: 865 LRGINGEARPARGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHWQHNGELAEGGA 924

Query: 190 -----PRPAP--------------SARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSA 230
                P P P              S R R     P ++ +S+ +  T EPSP AR     
Sbjct: 925 EPKDPPPPGPHSEDLKVPPGVVRKSRRGRRRKYNPTRNSNSSRQDITLEPSPTAR----- 979

Query: 231 GGGLQRPASRSLSSSATPLSSPARSGPSARGTPR 264
                         +A PL   AR G  A+   R
Sbjct: 980 --------------AAVPLPPRARPGRPAKNKRR 999



 Score = 32.0 bits (71), Expect = 2.5
 Identities = 53/204 (25%), Positives = 75/204 (36%), Gaps = 25/204 (12%)

Query: 12   AAARTPAARAPGLLTPRPP-GSPRPPPP--VTPAALRVLGAAGAVGRKPLAERAGGIGGA 68
            A+A  P    P L    PP GSP PP P  +T       G  G  G +       GI G 
Sbjct: 819  ASALEPEPARPPLSALAPPHGSPDPPVPELLTGRGSGKRGRRGGGGLR-------GINGE 871

Query: 69   TIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKN--TSPGPVSSPGRASGTTRP 126
              P    + G  R  G  +    +R   +G+ ER+P   +     G ++  G  +    P
Sbjct: 872  ARPARGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHWQHNGELAEGG--AEPKDP 929

Query: 127  GPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTE 186
             P G     +     V R K+    +R          +       PSP     +RAA   
Sbjct: 930  PPPGPHSEDLKVPPGVVR-KSRRGRRRKYNPTRNSNSSRQDITLEPSPT----ARAA--- 981

Query: 187  VGLPRPAPSARPRPPTEGPRKSVS 210
            V LP   P ARP  P +  R+ ++
Sbjct: 982  VPLP---PRARPGRPAKNKRRKLA 1002



 Score = 30.8 bits (68), Expect = 5.6
 Identities = 38/149 (25%), Positives = 50/149 (33%), Gaps = 12/149 (8%)

Query: 607 LAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYD---SGPEGGAAASPPPDAEL 663
           LAP  P      P+S      L  H   A +     R  +   S    G  ASP     +
Sbjct: 79  LAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTV 138

Query: 664 AACHPAAWSRGPAPPLA-FRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGAL 722
           +   P+A      PP     G PG+  P PP+                GP    P P   
Sbjct: 139 SPGPPSARPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPT-------LAGPGGLFP-PRLA 190

Query: 723 DPGPSPGTSGGKAAAGAGAGASSRSPKQA 751
           DP PS G+S  +      A + +  P  A
Sbjct: 191 DPVPSGGSSSPRFLPRGNAPSPAPPPPPA 219


>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
          Length = 2217

 Score =  140 bits (353), Expect = 5e-33
 Identities = 175/619 (28%), Positives = 227/619 (36%), Gaps = 83/619 (13%)

Query: 75   PRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVS-SPGRASGTTRPGPLGQKG 133
            P   P       S + A  PP   + +    A+   PGP       A     P  L    
Sbjct: 548  PALQPKEQQDVGSPDKARGPPVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLPPTLPTSA 607

Query: 134  LRISAEETVARGKATEA-----PKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVG 188
              ++++ T   G+ +         + ++  G+  D +      PSPA    S        
Sbjct: 608  TSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAA------PSPAQCVCSPPVSEGPV 661

Query: 189  LPRPAPSARP-RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSAT 247
            LP+  PS    + PT  P   V S        P+PA    PS       PA  S +    
Sbjct: 662  LPQSLPSLGAYQQPTAAPGLPVGSV-------PAPACP--PSLQQHFPDPAM-SFAPVLP 711

Query: 248  PLSSPARSGPSARGTPRAPAHPSQP--KPKGLQALRPPQVTPPRKDAAPALGPL--SSSP 303
            P S+P  +GP   G P  P     P  +P  L  +  PQ   P +   P L P    +S 
Sbjct: 712  PPSTPMPTGP---GQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQ 768

Query: 304  LATPS-------PSAALQ--SQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTL 354
            +  P+       P A LQ  +Q PP +P  P    +T     PL      P A P L T 
Sbjct: 769  VGAPAQLKPLQMPQAPLQPLAQVPPQMPPIPVVPPIT-----PLAGIDGLPPALPDLPTA 823

Query: 355  PSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATP--------PPQAPPALALPPLQ 406
              PP  PP   + ++  P+L A     P PP SP A P        PP AP  LA+P   
Sbjct: 824  TVPPVPPPQYFSPAVILPSLAA-----PLPPASP-ALPLQAVKLPHPPGAP--LAMPCRT 875

Query: 407  APPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP 466
              P+ PA+ PL  +A P   A   L++H   A     P  P   P   P   P SP  T 
Sbjct: 876  IVPNAPATIPLLAVAPPGVAA---LSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTV 932

Query: 467  PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATP 526
             +      A PP    P  P  PP  P   P P  PP    PP     P P  PP    P
Sbjct: 933  QNMR----ATPPQPALPPQPTLPPQ-PVLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLP 987

Query: 527  PLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAP 586
            P   LP  PA      P  P      +P ATP  Q        +L   P+P A     A 
Sbjct: 988  PQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQ--------ILLGHPAPYAVDV--AA 1037

Query: 587  RRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS--TLSGPDLAGHSSSATSTPEELRG 644
            + P  P P  +V  P L   L P  P    + PSS  T+S    +  + +AT  P     
Sbjct: 1038 QVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTATLLPPANPP 1097

Query: 645  YDSGPEGGAAASPPPDAEL 663
               GP     ASP P  +L
Sbjct: 1098 LPGGP---GIASPCPTVQL 1113



 Score =  102 bits (254), Expect = 2e-21
 Identities = 159/617 (25%), Positives = 230/617 (37%), Gaps = 97/617 (15%)

Query: 31   GSPRPPPPVTPAALRVL------GAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAG 84
            G P PP P  P A + L       +A ++      +   G    +  +S+ ++    S  
Sbjct: 582  GQPGPPEPEEPEADQHLLPPTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLA 641

Query: 85   TSSRNPAS---RPPASGRGERAP---PAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISA 138
             ++ +PA     PP S  G   P   P+      P ++PG   G+  P P     L+   
Sbjct: 642  DAAPSPAQCVCSPPVS-EGPVLPQSLPSLGAYQQPTAAPGLPVGSV-PAPACPPSLQQHF 699

Query: 139  EETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARP 198
             +          P  + +  G  +      PG   P +A+ +     +V  P+P    +P
Sbjct: 700  PDPAMSFAPVLPPPSTPMPTGPGQPAP---PGQQPPPLAQPTPLP--QVLAPQPVVPLQP 754

Query: 199  RPPTEGPRKSVSS---ASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARS 255
             PP   P  + +S   A         P A  +P A    Q P    +    TPL+     
Sbjct: 755  VPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPI-PVVPPITPLAGIDGL 813

Query: 256  GPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPS------P 309
             P+    P A   P  P      A+  P +  P   A+PAL PL +  L  P       P
Sbjct: 814  PPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPAL-PLQAVKLPHPPGAPLAMP 872

Query: 310  SAALQSQAPPTLP----ATPHSSSLTCQLATP-LPLAPPSPSAPPSLQTLPSPPATPPSQ 364
               +   AP T+P    A P  ++L+   A   LP  P  P+A P +    +P   PPS 
Sbjct: 873  CRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQM----APTDVPPSP 928

Query: 365  ATTSLGSPTLQATHSFLPSPPLSPLATPPPQA--PPALALPPLQAPPSPPASPPLSPLAT 422
                    T+Q   +  P P L P  T PPQ   PP   LPP    P  P  PP  P+  
Sbjct: 929  ------HHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPP-QPVLP 981

Query: 423  PSPQAPNALAVHLLQAPFSPPPSPPVQA-PFSPPASPPVSPSATPPSQ------APPSL- 474
            P P  P        Q    P P+ PV+  P  P      +P+ATP SQ      AP ++ 
Sbjct: 982  PQPMLPP-------QPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVD 1034

Query: 475  ---AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT--PPLQ 529
                 P + VPP+   SPP+     P        AAP L      PQ P +LAT    +Q
Sbjct: 1035 VAAQVPTVPVPPAAVLSPPLPEVLLP--------AAPELL-----PQFPSSLATVSASVQ 1081

Query: 530  ALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA--PLLQVPPSPPASPTLQAPR 587
            ++P+  A+              + P A PP    P +A+  P +Q+   P         +
Sbjct: 1082 SVPTQTAT--------------LLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDK 1127

Query: 588  RPPTPGPDTSVSGPRLT 604
             P  P    S  G  +T
Sbjct: 1128 PPGLPQSCESYGGSDVT 1144



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 118/436 (27%), Positives = 154/436 (35%), Gaps = 94/436 (21%)

Query: 265  APAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPAT 324
            AP  P    P  L +L PP+ +   +D+AP    LSS    +   S  L SQA P+ P  
Sbjct: 1323 APEAPESSPPLPLSSL-PPEAS---QDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPG 1378

Query: 325  PHSSSLTCQLATPLPLAPPSP--------SAPPSLQTLPSPPATPPSQATTSLGSPTLQA 376
                      A P PLAP SP         A P+  T+P P +   SQA    G  T Q 
Sbjct: 1379 ----------APPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAG---GPGTPQG 1425

Query: 377  THSFLP-SPPLS-----PLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNA 430
              S L  S PL+     PLA  P     A   P  +A  +  AS P  PL  P+P+    
Sbjct: 1426 LTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEP--- 1482

Query: 431  LAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPP 490
                   +P S  P P +  P       P+ P+A        SLA   L  PP  P  PP
Sbjct: 1483 -------SPHSGTPQPALGQP------APLLPAAV----GAVSLATSQLPSPPLGPTVPP 1525

Query: 491  MSPSATPPP-QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP---GQAPFS- 545
              PSA     + PPP         K   +    L         S  A  P   G   F+ 
Sbjct: 1526 QPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDFTL 1585

Query: 546  -------PSASLPMSPLATPPPQAPPVLAAPLLQVP----PSPPASPTLQAPRRPPTPGP 594
                   P + +    LA PP   P    +  +Q+P         +PT  A     T   
Sbjct: 1586 EPLRGDQPRSEVCGGDLALPP--VPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSS 1643

Query: 595  DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGY--------- 645
             T+ S PR  L                   G  +A  S    S P+++  +         
Sbjct: 1644 MTAESSPRSMLGY--------------DRDGRQVASDSHVVPSVPQDVPAFVRPARVEPT 1689

Query: 646  --DSGPEGGAAASPPP 659
              D G  G ++A PPP
Sbjct: 1690 DRDGGEAGESSAEPPP 1705



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 125/506 (24%), Positives = 170/506 (33%), Gaps = 96/506 (18%)

Query: 12   AAARTPAARAPGLLTPRPPGSP-----RPPPPVTPAAL-RVLGAAGAVGRKPLAERAGGI 65
            A +  P    P    P  PG P     +PPP   P  L +VL     V  +P+       
Sbjct: 703  AMSFAPVLPPPSTPMPTGPGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVP------ 756

Query: 66   GGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTR 125
                 P   P   P    G  ++    + P +     A       P PV  P        
Sbjct: 757  -----PHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPIPVVPP-------- 803

Query: 126  PGPL-GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184
              PL G  GL  +  +          P +    A      + P P   SPA+  ++    
Sbjct: 804  ITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLP-PASPALPLQAVKLP 862

Query: 185  TEVGLP--RPAPSARPRPPTEGP-----RKSVSSASEHSTTEPSPAARRRPSAGGGLQRP 237
               G P   P  +  P  P   P        V++ S HS     P     P+        
Sbjct: 863  HPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPA-------- 914

Query: 238  ASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG 297
            A   ++ +  P  SP  +  + R TP  PA P QP       L P  V PP+    P L 
Sbjct: 915  AFPQMAPTDVP-PSPHHTVQNMRATPPQPALPPQP------TLPPQPVLPPQ----PTLP 963

Query: 298  PLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAP-------PS 350
            P    P+  P P+   Q    P LP  P        +  P P+ PP P+ P       P 
Sbjct: 964  P---QPVLPPQPTRPPQ----PVLPPQP--------MLPPQPVLPPQPALPVRPEPLQPH 1008

Query: 351  LQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPS 410
            L    +P ATP SQ      +P      + +P+ P+ P A   P  P  L          
Sbjct: 1009 LPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLL--------- 1059

Query: 411  PPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQA 470
             PA+P L       PQ P++LA        S    P   A   PPA+PP+       S  
Sbjct: 1060 -PAAPEL------LPQFPSSLAT----VSASVQSVPTQTATLLPPANPPLPGGPGIASPC 1108

Query: 471  PP-SLAAPPLQVPPSPPASPPMSPSA 495
            P   L   P+Q   +    PP  P +
Sbjct: 1109 PTVQLTVEPVQEEQASQDKPPGLPQS 1134



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 143/590 (24%), Positives = 191/590 (32%), Gaps = 146/590 (24%)

Query: 104  PPAKNTSP-GPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARR 162
            P A++ +P  P SSP        P PL       S +    + + +   + S L++    
Sbjct: 1317 PVAEHPAPEAPESSP--------PLPLSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLL 1368

Query: 163  DTSGPT--PGTPSPAMARRSRAAGTEVGLPRPAPSARPRPP-TEGPRKSVSSASEHSTTE 219
              +GP+  PG P                   PAP A   PP T  P+   + A+   +T 
Sbjct: 1369 SQAGPSNPPGAP-------------------PAPLAPSSPPVTALPQDGAAPAT---STM 1406

Query: 220  PSPAARRRPSAGGGLQRPASRSLSSSATPLS----SPARSGPSARGTPRAPAHPSQPKPK 275
            P PA+     AGG        S   ++ PL+    +P    P   G       P     +
Sbjct: 1407 PEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTR 1466

Query: 276  GLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSL-TCQL 334
               A R P + PP  + +P  G        TP P+     Q  P LPA   + SL T QL
Sbjct: 1467 DASAPREP-LPPPAPEPSPHSG--------TPQPALG---QPAPLLPAAVGAVSLATSQL 1514

Query: 335  ATPLPLAPPSPSAPPS--------------------------LQTLPSPPATPPSQATTS 368
             +P PL P  P  PPS                          L+TL      P S A  S
Sbjct: 1515 PSP-PLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSA--S 1571

Query: 369  LGSPTLQATHSFLPSPPLSPLATPPPQAPPA---LALPPLQAPPSPPASPPLSPLATPSP 425
             G+P       F     L PL    P++      LALPP+             PL   S 
Sbjct: 1572 AGTPVEVGDRDFT----LEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSE 1627

Query: 426  QAPNALAV--HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPS--QAPPSLAAPPLQV 481
             AP   AV      +  +   SP     +        S S   PS  Q  P+   P    
Sbjct: 1628 LAPTRGAVMEQGTSSSMTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVE 1687

Query: 482  PPSPPASPPMSPSATPPPQA----------PPPLAAPPLQLAKPPPQ----APPA----- 522
            P           SA PPP            P  L A  L   +  P+    + PA     
Sbjct: 1688 PTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGR 1747

Query: 523  -----------LATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP------------- 558
                       LA+P      +PP  +  +AP SP   L +    T              
Sbjct: 1748 FSVVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVSS 1807

Query: 559  ------PPQAPPVLAAPLLQVPPS------PPASPTLQAPRRPPTPGPDT 596
                  P   PPV     L V  S        A+  LQ P R  + GP+T
Sbjct: 1808 DSGDEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPET 1857



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 122/503 (24%), Positives = 162/503 (32%), Gaps = 125/503 (24%)

Query: 76   RAGPTRSAGT--SSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKG 133
            +AGP+   G   +   P+S P  +   + A PA +T P P S     +G    GP   +G
Sbjct: 1370 QAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAG----GPGTPQG 1425

Query: 134  LRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPA 193
            L    E +    +  EAP         +    G  P TP+P  A    A+     LP PA
Sbjct: 1426 LTSELETSQPLAETHEAP------LAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPA 1479

Query: 194  PSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPA 253
            P   P   T  P          +  +P+P     P+A G +      SL++S  P  SP 
Sbjct: 1480 PEPSPHSGTPQP----------ALGQPAPLL---PAAVGAV------SLATSQLP--SP- 1517

Query: 254  RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL----------------G 297
                     P  P  P QP P  L++    +  PPR     +                  
Sbjct: 1518 ---------PLGPTVPPQP-PSALES--DGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHV 1565

Query: 298  PLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSP 357
            P SS+   TP           P     P S      LA      PP P    S +     
Sbjct: 1566 PTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLA-----LPPVPKEAVSGRVQLPQ 1620

Query: 358  PATPPSQATTSLGSPTLQATHSFL--PSPPLSPL---------------ATPPPQAPPAL 400
            P    S+   + G+   Q T S +   S P S L                   PQ  PA 
Sbjct: 1621 PLVEKSELAPTRGAVMEQGTSSSMTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAF 1680

Query: 401  ALPPLQAPP--------SPPASPPLSPLATPSPQA--PNALAVHLLQAPFSPPPSPPVQA 450
              P    P            A PP S + T   QA  P  L    L +P   P    V +
Sbjct: 1681 VRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSS 1740

Query: 451  P------FSPPASPPVSPSATPPS---QAPPSLAAPPLQVPPSPP--------------- 486
            P      FS  ++      A+P S    APP +    L   PS P               
Sbjct: 1741 PAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVY---LDEAPSSPDVKLAVRRAQTASSI 1797

Query: 487  ----ASPPMSPSATPPPQAPPPL 505
                  P  S S    P+A PP+
Sbjct: 1798 EVGVGEPVSSDSGDEGPRARPPV 1820



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 72/245 (29%), Positives = 95/245 (38%), Gaps = 39/245 (15%)

Query: 497  PPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLA 556
            P P+AP   ++PPL L+  PP+A    A P    L S       Q  F  S  L      
Sbjct: 1322 PAPEAPE--SSPPLPLSSLPPEASQDSA-PYKDQLSSKE-----QPSFLASQQLLSQAGP 1373

Query: 557  TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 616
            + PP APP   APL   P SPP +   Q    P T       SG   T + A GP  P  
Sbjct: 1374 SNPPGAPP---APL--APSSPPVTALPQDGAAPATSTMPEPASG---TASQAGGPGTPQG 1425

Query: 617  RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPA 676
             +     S P    H +     P  +        G A  +P P+A  A+   A+  R P 
Sbjct: 1426 LTSELETSQPLAETHEAPLAVQPLVV--------GLAPCTPAPEA--ASTRDASAPREPL 1475

Query: 677  PPLAFRGAPGAPLPWP----PATGPGSADGLCTIYETE------GPESATPAPGALD--- 723
            PP A   +P +  P P    PA    +A G  ++  ++      GP      P AL+   
Sbjct: 1476 PPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPPSALESDG 1535

Query: 724  PGPSP 728
             GP P
Sbjct: 1536 EGPPP 1540



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 69/237 (29%), Positives = 89/237 (37%), Gaps = 46/237 (19%)

Query: 515  PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVP 574
            P P+AP +  +PPL     PP +    AP+    S    P      Q        L Q  
Sbjct: 1322 PAPEAPES--SPPLPLSSLPPEASQDSAPYKDQLSSKEQPSFLASQQL-------LSQAG 1372

Query: 575  PS-PPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSS 633
            PS PP +P   AP  P +P P T++  P+   A A    P P+   +S   GP      +
Sbjct: 1373 PSNPPGAPP--APLAPSSP-PVTAL--PQDGAAPATSTMPEPASGTASQAGGPGTPQGLT 1427

Query: 634  SATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPP 693
            S   T + L      P     A  P    LA C PA      A       AP  PLP PP
Sbjct: 1428 SELETSQPLAETHEAP----LAVQPLVVGLAPCTPAP----EAASTRDASAPREPLP-PP 1478

Query: 694  ATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGG--KAAAGAGAGASSRSP 748
            A                 PE   P+P +  P P+ G       AA GA + A+S+ P
Sbjct: 1479 A-----------------PE---PSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLP 1515



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 109/459 (23%), Positives = 158/459 (34%), Gaps = 85/459 (18%)

Query: 11   GAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERA-GGIGGAT 69
            G A  TPA  A        P  P PPP   P+              PL   A G +  AT
Sbjct: 1452 GLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLAT 1511

Query: 70   IPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 129
                +P  GPT            +PP++         ++   GP    G    T +   L
Sbjct: 1512 SQLPSPPLGPT---------VPPQPPSA--------LESDGEGPPPRVGFVDSTIK--SL 1552

Query: 130  GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL 189
             +K   +  +E V    A+     + +  G R  T  P  G        RS   G ++ L
Sbjct: 1553 DEKLRTLLYQEHVPTSSASAG---TPVEVGDRDFTLEPLRGDQP-----RSEVCGGDLAL 1604

Query: 190  PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 249
            P P P        + P+  V         E S  A   P+ G  +++  S S+++ ++P 
Sbjct: 1605 P-PVPKEAVSGRVQLPQPLV---------EKSELA---PTRGAVMEQGTSSSMTAESSPR 1651

Query: 250  SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSP 309
            S         +    +   PS P+      +RP +V P  +D   A G  S+ P  +   
Sbjct: 1652 SMLGYDRDGRQVASDSHVVPSVPQDVP-AFVRPARVEPTDRDGGEA-GESSAEPPPSDMG 1709

Query: 310  SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
            +   Q+  P TL A                 A  SP   P  Q + SP  T    +  S 
Sbjct: 1710 TVGGQASHPQTLGAR----------------ALGSPRKRPEQQDVSSPAKTVGRFSVVST 1753

Query: 370  GSP-TLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAP 428
                TL + HS   S            APP + L   +AP SP        LA    Q  
Sbjct: 1754 QDEWTLASPHSLRYS------------APPDVYLD--EAPSSPDVK-----LAVRRAQTA 1794

Query: 429  NALAVHLLQAPFS------PPPSPPVQAPFSPPASPPVS 461
            +++ V + +   S      P   PPVQ   S P S  V+
Sbjct: 1795 SSIEVGVGEPVSSDSGDEGPRARPPVQKQASLPVSGSVA 1833



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 40/157 (25%), Positives = 58/157 (36%), Gaps = 25/157 (15%)

Query: 222 PAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALR 281
           P     P  G G   PA       A P +  AR GP  R   R+     Q +P GL+A  
Sbjct: 11  PGTLMEPGRGAG---PAGM-----AEPRAKAARPGPQ-RFLRRSVVESDQEEPPGLEAAE 61

Query: 282 PPQVTPPRKDAAPALGPLSSSPL---------ATPSPSAALQSQAPPTLPATPHSSSLTC 332
            P   PP+      L    +  L         A P+P+A +     P  PA      +  
Sbjct: 62  APGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGT 121

Query: 333 QLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369
           Q   P P+A        +++T P+P   P  +A  ++
Sbjct: 122 QEPGPDPIA-------AAVETAPAPDGGPREEAAATV 151



 Score = 37.0 bits (84), Expect = 0.078
 Identities = 40/154 (25%), Positives = 57/154 (37%), Gaps = 10/154 (6%)

Query: 249 LSSPAR-SGPSARGTPRAPAHPSQPKPKGL---QALRPPQVTPPRKDAAPALGPLSSSPL 304
           L  P R +GP+    PRA A  ++P P+       +   Q  PP  +AA A GP    PL
Sbjct: 14  LMEPGRGAGPAGMAEPRAKA--ARPGPQRFLRRSVVESDQEEPPGLEAAEAPGPQPPQPL 71

Query: 305 ATP----SPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT 360
                    +  L ++     PA P  ++L  Q   P   A   P    + +  P P A 
Sbjct: 72  QRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGPDPIAA 131

Query: 361 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPP 394
               A    G P  +A  +       +  A P P
Sbjct: 132 AVETAPAPDGGPREEAAATVRKEDEGAAEAKPEP 165



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 28/97 (28%), Positives = 41/97 (42%), Gaps = 4/97 (4%)

Query: 489 PPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSA 548
           P +  +  P PQ P PL    L L K            P    P+   + PG AP +P+ 
Sbjct: 55  PGLEAAEAPGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPG-APGAPAD 113

Query: 549 SLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585
           + P  P+ T  P   P+ AA  ++  P+P   P  +A
Sbjct: 114 AGP-EPVGTQEPGPDPIAAA--VETAPAPDGGPREEA 147



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 44/166 (26%), Positives = 51/166 (30%), Gaps = 18/166 (10%)

Query: 563 PPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSV------SGPRLTLALAPGPPPPPS 616
           P  L  P     P+  A P  +A R  P      SV        P L  A APGP PP  
Sbjct: 11  PGTLMEPGRGAGPAGMAEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAAEAPGPQPPQP 70

Query: 617 RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP--PDAELAACHPAAWSRG 674
                 L          +     E  RG  + P   A  + P  P A   A      ++ 
Sbjct: 71  LQRRVLLL-------CKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQE 123

Query: 675 PAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 720
           P P         AP    P  GP          E EG   A P PG
Sbjct: 124 PGPDPIAAAVETAP---APDGGPREEAAATVRKEDEGAAEAKPEPG 166



 Score = 30.4 bits (67), Expect = 7.3
 Identities = 39/155 (25%), Positives = 56/155 (36%), Gaps = 30/155 (19%)

Query: 111 PGPVSSPGRASG----------TTRPGPLGQKGLRISAEETVARG----KATEAP----- 151
           PG +  PGR +G            RPGP  Q+ LR S  E+        +A EAP     
Sbjct: 11  PGTLMEPGRGAGPAGMAEPRAKAARPGP--QRFLRRSVVESDQEEPPGLEAAEAPGPQPP 68

Query: 152 ----KRSALSAGARR---DTSGPTPGTPSPA-MARRSRAAGTEVGL-PRPAPSARPRPPT 202
               +R  L    RR   + +   P  P+PA +  +  A G      P P  +  P P  
Sbjct: 69  QPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGPDP 128

Query: 203 EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRP 237
                  + A +    E + A  R+   G    +P
Sbjct: 129 IAAAVETAPAPDGGPREEAAATVRKEDEGAAEAKP 163


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score =  140 bits (353), Expect = 5e-33
 Identities = 193/722 (26%), Positives = 268/722 (37%), Gaps = 100/722 (13%)

Query: 100 GERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEA---PKRSAL 156
           G RAPP   T P  ++ PG   G     PL    + IS + T        A   P    +
Sbjct: 311 GTRAPPL--TRPMSLAVPGLTGGAGPAEPLSP-AMSISPQATYLSKLIPHAVLPPTVDVV 367

Query: 157 SAG--ARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 214
           + G  + R  S  +  + SPA  R   + G    +  P P +R  P +     S S +S+
Sbjct: 368 ALGRCSLRTLSRCSLHSASPASVR---SLGRFSSVSSPQPRSR-HPSSSSDTWSHSQSSD 423

Query: 215 HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATP--LSSPARSGPSARGTPRAPAHPS-- 270
              ++ S  +    S GG   +P S + S+S  P       R  PS   T  A    S  
Sbjct: 424 TIVSDGSTLS----SKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIR 479

Query: 271 -----QPKPKGLQALRPPQVTPPRKDAAPALG-PLSSSPLATPSPSAALQSQAPPTLPAT 324
                  +   L+ L+ P   P R  +    G  +   PL  P      Q    P LP  
Sbjct: 480 SSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQ---PQLPRP 536

Query: 325 PHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSP 384
           P +       A P P   P+ S  P L   P     PP     +L   +  ++ S  P+ 
Sbjct: 537 PTTGGSEGAGAAPCP-PNPANSWVPGLS--PGGSRRPPRSPERTLSPSSGYSSQSGTPTL 593

Query: 385 PLSPLATPPPQAPPALALPP-------LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ 437
           P   LA PP  A P  A PP       L++P +  +S   S  ++ S  AP+  +   + 
Sbjct: 594 PPKGLAGPP--ASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQIL 651

Query: 438 AP----FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP 493
            P    F  PP P V APFSPP S P SP+   P+ A P++   P+    + P SPP   
Sbjct: 652 TPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQ 711

Query: 494 SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMS 553
           +   P Q  P ++        PPP  PP+   PP      PP   P     +PSA    S
Sbjct: 712 TTLTPLQESPVISKD----QSPPPSPPPSYHPPP------PPTKKPEVVVEAPSA----S 757

Query: 554 PLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPP 613
             A  P Q P          PP PP +P  Q       P P+ +        ++A   P 
Sbjct: 758 ETAEEPLQDP--------NWPPPPPPAPEEQDLSMADFPPPEEAF------FSVASPEPA 803

Query: 614 PPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSR 673
            PS SP   +S P  A  SSSAT+   +  G         +  PPP              
Sbjct: 804 GPSGSP-ELVSSP--AASSSSATALQIQPPG---------SPDPPP-------------- 837

Query: 674 GPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGG 733
            P  P     APG     P     G + G     E  G    TP+   +    S G  GG
Sbjct: 838 APPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGG 897

Query: 734 KAAAGAGAGASSRSPKQARLGEL-PLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGG 792
                 G  A  +  ++A  G   P+ A  + +   +  +   LAA+EG +     GP  
Sbjct: 898 APTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPE 957

Query: 793 AE 794
           AE
Sbjct: 958 AE 959



 Score =  110 bits (276), Expect = 4e-24
 Identities = 190/714 (26%), Positives = 255/714 (35%), Gaps = 176/714 (24%)

Query: 36   PPPVTPAAL-----RVLGAAGAVGRKPLAERA-GGIGGATIPESAPRAGPTRSAGTSSRN 89
            PP V   AL     R L         P + R+ G     + P+   R  P+ S+ T S +
Sbjct: 361  PPTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRH-PSSSSDTWSHS 419

Query: 90   PASRPPAS--------GRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEET 141
             +S    S        G  E  P +   S   V  P   SG  R  P G  G    A +T
Sbjct: 420  QSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSG--RGSPSG--GSTAEASDT 475

Query: 142  VARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT-EVGLPRPAPSAR--- 197
            ++      + + S  S   R+    P P   + ++ +R  A     +GLP P P  +   
Sbjct: 476  LS---IRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLP-PKPERKQQP 531

Query: 198  --PRPPTEGPRKSVSSASEHSTTEPSPAARRRP--SAGGGLQRPAS--RSLSSSA---TP 248
              PRPPT G  +   +A       P+PA    P  S GG  + P S  R+LS S+   + 
Sbjct: 532  QLPRPPTTGGSEGAGAAP----CPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQ 587

Query: 249  LSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPP---------QVTPPRKDAAPA---- 295
              +P        G P +P     PKP+ + +LR P          +     D AP+    
Sbjct: 588  SGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSG 647

Query: 296  ---LGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQ 352
               L PL    +  P P        PP+ P +P+ ++    LA P  +  P  +   S  
Sbjct: 648  PQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPA--LAAPAVVPGPVSTTDAS-- 703

Query: 353  TLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP--------- 403
              P  P TP +  T    SP +    S  PSPP S    PPP   P + +          
Sbjct: 704  --PQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAE 761

Query: 404  -PLQAPPSPPASPPL-------------------------------SPLATPSPQAPNAL 431
             PLQ P  PP  PP                                SP    SP A ++ 
Sbjct: 762  EPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSS 821

Query: 432  AVHL-LQAPFSP--PPSPPVQAPFSP--------PASPPV--SPSATPPSQ---AP---P 472
            A  L +Q P SP  PP+PP  AP S         P   PV  S    PP +   AP   P
Sbjct: 822  ATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTP 881

Query: 473  SL-------------AAPPLQVPPSPPASP---PMSPSATPPPQAPPPL-AAPPLQ---- 511
            SL              AP   + PS P  P    +S  A+P P     L AA  L+    
Sbjct: 882  SLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSL 941

Query: 512  -----LAKPPPQAPPALATPPLQALPSPPASF---------PGQAPFSPSASLPM----- 552
                 L+   P  PP     P Q+ P+  ASF           + P SP     +     
Sbjct: 942  AASEGLSSAQPNGPPEAEPRPPQS-PASTASFIFSKGSRKLQLERPVSPETQADLQRNLV 1000

Query: 553  ----SPLATPPPQAP--------PVLAAPLLQVPP-SPPASPTLQAPRRPPTPG 593
                S     PPQAP        PV   P + VPP + P+ P  +    PPT G
Sbjct: 1001 AELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNG 1054



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 165/638 (25%), Positives = 220/638 (34%), Gaps = 139/638 (21%)

Query: 13   AARTPAARAPGLLTPRPPGSPR----PPPPVTPAALRVLGAA---GAVGRKPLAERAGGI 65
            A+ T + R+ G L+ R     +    PPPP    +L   G A   G +G  P  ER    
Sbjct: 472  ASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQ-- 529

Query: 66   GGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTR 125
                     PR  P  + G+     A  PP         PA +  PG   SPG   G+ R
Sbjct: 530  -----QPQLPR--PPTTGGSEGAGAAPCPPN--------PANSWVPG--LSPG---GSRR 569

Query: 126  PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT 185
            P    ++ L  S+  +   G  T  PK  A   G         P  P    + RS  A  
Sbjct: 570  PPRSPERTLSPSSGYSSQSGTPTLPPKGLA---GPPASPGKAQPPKPERVTSLRSPGASV 626

Query: 186  EVGLPR-------PAPSARPRPPTEGPRKSVSSASEHSTT----EPSPAARRRPSAGGGL 234
               L         PAPS R  P    P         H        P P+  R P+     
Sbjct: 627  SSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPN----- 681

Query: 235  QRPASRSLSSSAT---PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKD 291
              PA+ +L++ A    P+S+   S P +  TP+    P Q  P   +   PP   PP   
Sbjct: 682  --PAAPALAAPAVVPGPVSTTDAS-PQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYH 738

Query: 292  AAPALGPLSSSPLATPSPSAALQSQAP-------PTLPATPHSSSLTCQLATP-----LP 339
              P   P     +   +PSA+  ++ P       P  P  P    L+     P       
Sbjct: 739  PPPP--PTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFS 796

Query: 340  LAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA-TPPPQAPP 398
            +A P P+ P     L S PA   S AT       LQ      P PP +P A  P   AP 
Sbjct: 797  VASPEPAGPSGSPELVSSPAASSSSATA------LQIQPPGSPDPPPAPPAPAPASSAPG 850

Query: 399  ALALPPLQAPPS------PPASPPLSPLATPSPQAPNALAVHLLQAPFSPP--------P 444
             +A  P + P        PP     +PL TPS      + +  + AP   P        P
Sbjct: 851  HVAKLPQKEPVGCSKGGGPPREDVGAPLVTPS--LLQMVRLRSVGAPGGAPTPALGPSAP 908

Query: 445  SPPVQAPFSPPASPPVSPSATPPSQ---------APPSLAAPPLQVPPSPPASPPMSPSA 495
              P++   S  ASP  +PS+   +          A   L++     PP     PP SP++
Sbjct: 909  QKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPAS 968

Query: 496  TPP--------------PQAPPPLA---------------APPLQLAKPPPQAPPALATP 526
            T                P +P   A                 P Q  K  P+APP +A  
Sbjct: 969  TASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARK 1028

Query: 527  PLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPP 564
            P   +P PPAS     P  P A     PL  PP    P
Sbjct: 1029 PSVGVP-PPAS-----PSYPRA----EPLTAPPTNGLP 1056


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score =  138 bits (348), Expect = 2e-32
 Identities = 177/638 (27%), Positives = 247/638 (38%), Gaps = 97/638 (15%)

Query: 56  KPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVS 115
           KP+ E   G+ G    + + R   +R + ++ R+   + PAS  G  +P  ++      +
Sbjct: 3   KPVKEEDDGLSG----KHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRN 58

Query: 116 SPGRASGTTRPGPLG--QKGLRISAEETVARGKA-----------TEAPKRSALSAGARR 162
           SP  AS ++        +K  +   EE  +  K+           TE   R++      +
Sbjct: 59  SPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQ 118

Query: 163 DTSGPTPGTPSPAMARRSRAAGTEVG-----LPRPAPSARPRPPTEGPRKSVS-SASEHS 216
           + S P   +     +  SR+   E       + +   S  P  P+    +S S S+++  
Sbjct: 119 EISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQ 178

Query: 217 TTEPSPAARRRP--------SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAH 268
             +  P A + P        SA  G  +  +   + SAT +  P +  P+A   P  P  
Sbjct: 179 MLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAV--PPQGSPTASQAPNQPQA 236

Query: 269 PSQPKPK-------GLQALRPPQV-TPPRKDAAPALGPLSSSPLATPSPSAA---LQSQA 317
           P+ P P         L   RPP    PP     P L PL+ S     +PS A   L  Q 
Sbjct: 237 PTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQG 296

Query: 318 PPTLPATPHSSSLTCQLATPLPLAPPSP-SAPPSLQTLPSPPATPPSQAT--TSLGSPTL 374
           PP     PHS      L  P    PP P   PP      +P  T P+ A   TSL  P  
Sbjct: 297 PPG----PHSLQAGPLLQHP---GPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPAS 349

Query: 375 QATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 434
           Q+       P   PL    P AP  LA+P ++ PP+ P  P L     P+PQA       
Sbjct: 350 QSALQSQQPPREQPL----PPAP--LAMPHIKPPPTTPI-PQL-----PAPQAHKHPPHL 397

Query: 435 LLQAPFSPPPSPPVQAPFSPPASPPVSPSAT--PPSQAPPSLAAPPLQVP-PSPPASPP- 490
              +PFS   + P      PPA  P+S  +T  PPS  PP L   P   P PS PA PP 
Sbjct: 398 SGPSPFSMNANLP-----PPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPG 452

Query: 491 MSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL 550
           ++ S   P   PPP + PP  L +  PQ P A                  Q PF P    
Sbjct: 453 LTQSQNLP---PPPASHPPTGLHQVAPQPPFA------------------QHPFVPGGPP 491

Query: 551 PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPG 610
           P++P   P    PP       Q P S  A+           P P   +    L  A  P 
Sbjct: 492 PITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPE 551

Query: 611 PPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL-RGYDS 647
            PPPP RSPS   +  D   H+S +    + L RGY+S
Sbjct: 552 SPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNS 589



 Score =  117 bits (292), Expect = 6e-26
 Identities = 139/531 (26%), Positives = 196/531 (36%), Gaps = 99/531 (18%)

Query: 70  IPESAPRAGPTRSAGTSSRNPASRP--PASGRGERAPPAK-----NTSPGPVSSPGRASG 122
           +      A  T S  T ++   SRP  P+ G GE +         ++ P  +    R++ 
Sbjct: 100 VASDTEEADRTSSKKTKTQE-ISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTS 158

Query: 123 TTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA 182
            + P P   +    S  ++ A+ +  +A +  AL A        PT  TP+P+ A     
Sbjct: 159 PSIPSPQDNE----SDSDSSAQQQMLQA-QPPALQA--------PTGVTPAPSSA----P 201

Query: 183 AGT-EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241
            GT ++  P P PSA   PP   P  S +     + T P P    + +     QRP S  
Sbjct: 202 PGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPH 261

Query: 242 LSSSATPLSSPARSGPSARGTPRAPAHPSQPK----PKGLQALR---------PPQVTPP 288
                +P   P +    + G P AP+H   P     P G  +L+         PPQ    
Sbjct: 262 PPPHPSP-HPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGL 320

Query: 289 RKDAAPALGPLSSSPLAT--------PSPSAALQSQAPPTLPATPHSSSLTCQLATPLPL 340
              A+    PL +SP A         P+  +ALQSQ PP     P           P PL
Sbjct: 321 PPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLP-----------PAPL 369

Query: 341 APPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP-LSPLATPPPQAPPA 399
           A P    PP+   +P  PA    +    L  P+  + ++ LP PP L PL++     PP+
Sbjct: 370 AMPHIKPPPTTP-IPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPS 428

Query: 400 LALPPLQAPPSP---PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP-VQAPFSPP 455
              PPLQ  P     P+SP   P  T S   P   A H         P PP  Q PF P 
Sbjct: 429 AHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPG 488

Query: 456 ASPPVSPSATPPSQAPP-------------------------SLAAPPLQVP-------- 482
             PP++P   P +  PP                         S   P +Q+         
Sbjct: 489 GPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAE 548

Query: 483 -PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 532
            P  P  PP SPS  P     P  A+   +  K   +   + A   L  +P
Sbjct: 549 EPESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMP 599



 Score =  115 bits (288), Expect = 2e-25
 Identities = 156/555 (28%), Positives = 211/555 (38%), Gaps = 98/555 (17%)

Query: 225 RRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQ 284
           +++P++  G   P +  + SS        R+ PSA  T    +     K K  + ++   
Sbjct: 35  KKQPASPDGRTSPINEDIRSSG-------RNSPSAASTSSNDSKAETVK-KSAKKVKEEA 86

Query: 285 VTPPRKDAAPALGPLSSSPLA--TPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAP 342
            +P + +        S +  A  T S     Q  + P  P+     S   +       + 
Sbjct: 87  SSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSD 146

Query: 343 PSPSAPPSLQTLPSPPATPP--SQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL 400
           P      +  T PS P+     S + +S     LQA    L +P  + +   P  APP  
Sbjct: 147 PKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAP--TGVTPAPSSAPPGT 204

Query: 401 ALPPLQAP-PSPPASPPL-SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP 458
              P   P PS  A PP  SP A+ +P  P        QAP +P P   +Q   +P   P
Sbjct: 205 PQLPTPGPTPSATAVPPQGSPTASQAPNQP--------QAPTAPVPHTHIQQ--APALHP 254

Query: 459 PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP---QAPPPLAAPPLQLAKP 515
              PS  PP    P    PPLQ P +  A  P +PS   PP   Q PP     P  L   
Sbjct: 255 QRPPSPHPPPHPSPH---PPLQ-PLTGSAGQPSAPSHAQPPLHGQGPPG----PHSL--- 303

Query: 516 PPQAPPALATP-PLQALPSPPASFPGQAPF--SPSASLPMSPLATP----------PPQA 562
             QA P L  P P Q    PP +  GQAP   SP+A+ P + L  P          PP+ 
Sbjct: 304 --QAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPRE 361

Query: 563 PPVLAAPL----LQVPPSPPAS--PTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 616
            P+  APL    ++ PP+ P    P  QA + PP       +SGP    ++    PPPP+
Sbjct: 362 QPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPP------HLSGPS-PFSMNANLPPPPA 414

Query: 617 RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELA------ACHPAA 670
             P S+LS      H  SA   P +L    S P   + A PP   +        A HP  
Sbjct: 415 LKPLSSLS----THHPPSAHPPPLQLMP-QSQPLPSSPAQPPGLTQSQNLPPPPASHPPT 469

Query: 671 WSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGT 730
                AP   F   P  P   PP T P              P ++TP  G       PGT
Sbjct: 470 GLHQVAPQPPFAQHPFVPGGPPPITPPTC------------PSTSTPPAG-------PGT 510

Query: 731 SGGKAAAGAGAGASS 745
           S     +GA A   S
Sbjct: 511 SAQPPCSGAAASGGS 525



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 127/480 (26%), Positives = 166/480 (34%), Gaps = 104/480 (21%)

Query: 14  ARTPAARAPGLLTP----RPPGSPR-PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA 68
           A+ PA +AP  +TP     PPG+P+ P P  TP+A  V                      
Sbjct: 182 AQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAV---------------------- 219

Query: 69  TIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAP---PAKNTSPGPVSSPGRASGTTR 125
                 P+  PT S   +     + P      ++AP   P +  SP P   P        
Sbjct: 220 -----PPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPS------- 267

Query: 126 PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT---PGTPSPAMARRSRA 182
           P P  Q  L  SA +  A   A + P       G     +GP    PG P P        
Sbjct: 268 PHPPLQP-LTGSAGQPSAPSHA-QPPLHGQGPPGPHSLQAGPLLQHPGPPQP-------- 317

Query: 183 AGTEVGLPRPAPSAR----PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPA 238
                GLP  A   +      P    P  S+   +  S  +     R +P        PA
Sbjct: 318 ----FGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLP------PA 367

Query: 239 SRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP 298
             ++     P ++P    P+ +   + P H S P P  + A  PP          PAL P
Sbjct: 368 PLAMPHIKPPPTTPIPQLPAPQ-AHKHPPHLSGPSPFSMNANLPP---------PPALKP 417

Query: 299 LSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPP 358
           LSS  L+T  P +A     PP L   P S         PLP +P  P      Q LP PP
Sbjct: 418 LSS--LSTHHPPSA----HPPPLQLMPQSQ--------PLPSSPAQPPGLTQSQNLPPPP 463

Query: 359 ATPPSQATTSLGSPTLQATHSFLPS--PPLSPLATPPPQAPPALALPPLQAPPSPPASPP 416
           A+ P      +      A H F+P   PP++P   P    PP        A P   A PP
Sbjct: 464 ASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPP--------AGPGTSAQPP 515

Query: 417 LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAA 476
            S  A          +  L             + P SPP  PP SPS  P     PS A+
Sbjct: 516 CSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPP-PPPRSPSPEPTVVDTPSHAS 574



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 69/257 (26%), Positives = 90/257 (35%), Gaps = 69/257 (26%)

Query: 532 PSPPASFPGQAPFSPSASLPMSPLATPPPQAPP-VLAAPLLQVPPSPPASPTLQAPRRPP 590
           PS P+    ++    SA   M     P  QAP  V  AP      +PP +P L      P
Sbjct: 159 PSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAP----SSAPPGTPQL------P 208

Query: 591 TPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPE 650
           TPGP  S +      A+ P   P  S++P+   +      H+    +           P+
Sbjct: 209 TPGPTPSAT------AVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALH-------PQ 255

Query: 651 GGAAASPPPDAELAACHPAAWSRGPAPPL----AFRGAPGAPL-PWPPATGPGSADGLCT 705
              +  PPP       HP+     P PPL       G P AP    PP  G G       
Sbjct: 256 RPPSPHPPP-------HPS-----PHPPLQPLTGSAGQPSAPSHAQPPLHGQGPP----- 298

Query: 706 IYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASV 765
                GP S    P    PGP P   G               P QA  G+ PLG   A+ 
Sbjct: 299 -----GPHSLQAGPLLQHPGP-PQPFG--------------LPPQASQGQAPLGTSPAAA 338

Query: 766 VQHLLSRTLLLAAAEGA 782
             H    +L L A++ A
Sbjct: 339 YPH---TSLQLPASQSA 352


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  138 bits (348), Expect = 2e-32
 Identities = 177/638 (27%), Positives = 247/638 (38%), Gaps = 97/638 (15%)

Query: 56   KPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVS 115
            KP+ E   G+ G    + + R   +R + ++ R+   + PAS  G  +P  ++      +
Sbjct: 557  KPVKEEDDGLSG----KHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRN 612

Query: 116  SPGRASGTTRPGPLG--QKGLRISAEETVARGKA-----------TEAPKRSALSAGARR 162
            SP  AS ++        +K  +   EE  +  K+           TE   R++      +
Sbjct: 613  SPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQ 672

Query: 163  DTSGPTPGTPSPAMARRSRAAGTEVG-----LPRPAPSARPRPPTEGPRKSVS-SASEHS 216
            + S P   +     +  SR+   E       + +   S  P  P+    +S S S+++  
Sbjct: 673  EISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQ 732

Query: 217  TTEPSPAARRRP--------SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAH 268
              +  P A + P        SA  G  +  +   + SAT +  P +  P+A   P  P  
Sbjct: 733  MLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAV--PPQGSPTASQAPNQPQA 790

Query: 269  PSQPKPK-------GLQALRPPQV-TPPRKDAAPALGPLSSSPLATPSPSAA---LQSQA 317
            P+ P P         L   RPP    PP     P L PL+ S     +PS A   L  Q 
Sbjct: 791  PTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQG 850

Query: 318  PPTLPATPHSSSLTCQLATPLPLAPPSP-SAPPSLQTLPSPPATPPSQAT--TSLGSPTL 374
            PP     PHS      L  P    PP P   PP      +P  T P+ A   TSL  P  
Sbjct: 851  PPG----PHSLQAGPLLQHP---GPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPAS 903

Query: 375  QATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 434
            Q+       P   PL    P AP  LA+P ++ PP+ P  P L     P+PQA       
Sbjct: 904  QSALQSQQPPREQPL----PPAP--LAMPHIKPPPTTPI-PQL-----PAPQAHKHPPHL 951

Query: 435  LLQAPFSPPPSPPVQAPFSPPASPPVSPSAT--PPSQAPPSLAAPPLQVP-PSPPASPP- 490
               +PFS   + P      PPA  P+S  +T  PPS  PP L   P   P PS PA PP 
Sbjct: 952  SGPSPFSMNANLP-----PPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPG 1006

Query: 491  MSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL 550
            ++ S   P   PPP + PP  L +  PQ P A                  Q PF P    
Sbjct: 1007 LTQSQNLP---PPPASHPPTGLHQVAPQPPFA------------------QHPFVPGGPP 1045

Query: 551  PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPG 610
            P++P   P    PP       Q P S  A+           P P   +    L  A  P 
Sbjct: 1046 PITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPE 1105

Query: 611  PPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL-RGYDS 647
             PPPP RSPS   +  D   H+S +    + L RGY+S
Sbjct: 1106 SPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNS 1143



 Score =  117 bits (292), Expect = 6e-26
 Identities = 139/531 (26%), Positives = 196/531 (36%), Gaps = 99/531 (18%)

Query: 70   IPESAPRAGPTRSAGTSSRNPASRP--PASGRGERAPPAK-----NTSPGPVSSPGRASG 122
            +      A  T S  T ++   SRP  P+ G GE +         ++ P  +    R++ 
Sbjct: 654  VASDTEEADRTSSKKTKTQE-ISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTS 712

Query: 123  TTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA 182
             + P P   +    S  ++ A+ +  +A +  AL A        PT  TP+P+ A     
Sbjct: 713  PSIPSPQDNE----SDSDSSAQQQMLQA-QPPALQA--------PTGVTPAPSSA----P 755

Query: 183  AGT-EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241
             GT ++  P P PSA   PP   P  S +     + T P P    + +     QRP S  
Sbjct: 756  PGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPH 815

Query: 242  LSSSATPLSSPARSGPSARGTPRAPAHPSQPK----PKGLQALR---------PPQVTPP 288
                 +P   P +    + G P AP+H   P     P G  +L+         PPQ    
Sbjct: 816  PPPHPSP-HPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGL 874

Query: 289  RKDAAPALGPLSSSPLAT--------PSPSAALQSQAPPTLPATPHSSSLTCQLATPLPL 340
               A+    PL +SP A         P+  +ALQSQ PP     P           P PL
Sbjct: 875  PPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLP-----------PAPL 923

Query: 341  APPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP-LSPLATPPPQAPPA 399
            A P    PP+   +P  PA    +    L  P+  + ++ LP PP L PL++     PP+
Sbjct: 924  AMPHIKPPPTTP-IPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPS 982

Query: 400  LALPPLQAPPSP---PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP-VQAPFSPP 455
               PPLQ  P     P+SP   P  T S   P   A H         P PP  Q PF P 
Sbjct: 983  AHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPG 1042

Query: 456  ASPPVSPSATPPSQAPP-------------------------SLAAPPLQVP-------- 482
              PP++P   P +  PP                         S   P +Q+         
Sbjct: 1043 GPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAE 1102

Query: 483  -PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 532
             P  P  PP SPS  P     P  A+   +  K   +   + A   L  +P
Sbjct: 1103 EPESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMP 1153



 Score =  115 bits (288), Expect = 2e-25
 Identities = 156/555 (28%), Positives = 211/555 (38%), Gaps = 98/555 (17%)

Query: 225  RRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQ 284
            +++P++  G   P +  + SS        R+ PSA  T    +     K K  + ++   
Sbjct: 589  KKQPASPDGRTSPINEDIRSSG-------RNSPSAASTSSNDSKAETVK-KSAKKVKEEA 640

Query: 285  VTPPRKDAAPALGPLSSSPLA--TPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAP 342
             +P + +        S +  A  T S     Q  + P  P+     S   +       + 
Sbjct: 641  SSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSD 700

Query: 343  PSPSAPPSLQTLPSPPATPP--SQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL 400
            P      +  T PS P+     S + +S     LQA    L +P  + +   P  APP  
Sbjct: 701  PKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAP--TGVTPAPSSAPPGT 758

Query: 401  ALPPLQAP-PSPPASPPL-SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP 458
               P   P PS  A PP  SP A+ +P  P        QAP +P P   +Q   +P   P
Sbjct: 759  PQLPTPGPTPSATAVPPQGSPTASQAPNQP--------QAPTAPVPHTHIQQ--APALHP 808

Query: 459  PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP---QAPPPLAAPPLQLAKP 515
               PS  PP    P    PPLQ P +  A  P +PS   PP   Q PP     P  L   
Sbjct: 809  QRPPSPHPPPHPSPH---PPLQ-PLTGSAGQPSAPSHAQPPLHGQGPPG----PHSL--- 857

Query: 516  PPQAPPALATP-PLQALPSPPASFPGQAPF--SPSASLPMSPLATP----------PPQA 562
              QA P L  P P Q    PP +  GQAP   SP+A+ P + L  P          PP+ 
Sbjct: 858  --QAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPRE 915

Query: 563  PPVLAAPL----LQVPPSPPAS--PTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 616
             P+  APL    ++ PP+ P    P  QA + PP       +SGP    ++    PPPP+
Sbjct: 916  QPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPP------HLSGPS-PFSMNANLPPPPA 968

Query: 617  RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELA------ACHPAA 670
              P S+LS      H  SA   P +L    S P   + A PP   +        A HP  
Sbjct: 969  LKPLSSLS----THHPPSAHPPPLQLMP-QSQPLPSSPAQPPGLTQSQNLPPPPASHPPT 1023

Query: 671  WSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGT 730
                 AP   F   P  P   PP T P              P ++TP  G       PGT
Sbjct: 1024 GLHQVAPQPPFAQHPFVPGGPPPITPPTC------------PSTSTPPAG-------PGT 1064

Query: 731  SGGKAAAGAGAGASS 745
            S     +GA A   S
Sbjct: 1065 SAQPPCSGAAASGGS 1079



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 127/480 (26%), Positives = 166/480 (34%), Gaps = 104/480 (21%)

Query: 14   ARTPAARAPGLLTP----RPPGSPR-PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA 68
            A+ PA +AP  +TP     PPG+P+ P P  TP+A  V                      
Sbjct: 736  AQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAV---------------------- 773

Query: 69   TIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAP---PAKNTSPGPVSSPGRASGTTR 125
                  P+  PT S   +     + P      ++AP   P +  SP P   P        
Sbjct: 774  -----PPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPS------- 821

Query: 126  PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT---PGTPSPAMARRSRA 182
            P P  Q  L  SA +  A   A + P       G     +GP    PG P P        
Sbjct: 822  PHPPLQP-LTGSAGQPSAPSHA-QPPLHGQGPPGPHSLQAGPLLQHPGPPQP-------- 871

Query: 183  AGTEVGLPRPAPSAR----PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPA 238
                 GLP  A   +      P    P  S+   +  S  +     R +P        PA
Sbjct: 872  ----FGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLP------PA 921

Query: 239  SRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP 298
              ++     P ++P    P+ +   + P H S P P  + A  PP          PAL P
Sbjct: 922  PLAMPHIKPPPTTPIPQLPAPQ-AHKHPPHLSGPSPFSMNANLPP---------PPALKP 971

Query: 299  LSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPP 358
            LSS  L+T  P +A     PP L   P S         PLP +P  P      Q LP PP
Sbjct: 972  LSS--LSTHHPPSA----HPPPLQLMPQSQ--------PLPSSPAQPPGLTQSQNLPPPP 1017

Query: 359  ATPPSQATTSLGSPTLQATHSFLPS--PPLSPLATPPPQAPPALALPPLQAPPSPPASPP 416
            A+ P      +      A H F+P   PP++P   P    PP        A P   A PP
Sbjct: 1018 ASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPP--------AGPGTSAQPP 1069

Query: 417  LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAA 476
             S  A          +  L             + P SPP  PP SPS  P     PS A+
Sbjct: 1070 CSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPP-PPPRSPSPEPTVVDTPSHAS 1128



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 69/257 (26%), Positives = 90/257 (35%), Gaps = 69/257 (26%)

Query: 532 PSPPASFPGQAPFSPSASLPMSPLATPPPQAPP-VLAAPLLQVPPSPPASPTLQAPRRPP 590
           PS P+    ++    SA   M     P  QAP  V  AP      +PP +P L      P
Sbjct: 713 PSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAP----SSAPPGTPQL------P 762

Query: 591 TPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPE 650
           TPGP  S +      A+ P   P  S++P+   +      H+    +           P+
Sbjct: 763 TPGPTPSAT------AVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALH-------PQ 809

Query: 651 GGAAASPPPDAELAACHPAAWSRGPAPPL----AFRGAPGAPL-PWPPATGPGSADGLCT 705
              +  PPP       HP+     P PPL       G P AP    PP  G G       
Sbjct: 810 RPPSPHPPP-------HPS-----PHPPLQPLTGSAGQPSAPSHAQPPLHGQGPP----- 852

Query: 706 IYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASV 765
                GP S    P    PGP P   G               P QA  G+ PLG   A+ 
Sbjct: 853 -----GPHSLQAGPLLQHPGP-PQPFG--------------LPPQASQGQAPLGTSPAAA 892

Query: 766 VQHLLSRTLLLAAAEGA 782
             H    +L L A++ A
Sbjct: 893 YPH---TSLQLPASQSA 906


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  138 bits (348), Expect = 2e-32
 Identities = 177/638 (27%), Positives = 247/638 (38%), Gaps = 97/638 (15%)

Query: 56   KPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVS 115
            KP+ E   G+ G    + + R   +R + ++ R+   + PAS  G  +P  ++      +
Sbjct: 557  KPVKEEDDGLSG----KHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRN 612

Query: 116  SPGRASGTTRPGPLG--QKGLRISAEETVARGKA-----------TEAPKRSALSAGARR 162
            SP  AS ++        +K  +   EE  +  K+           TE   R++      +
Sbjct: 613  SPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQ 672

Query: 163  DTSGPTPGTPSPAMARRSRAAGTEVG-----LPRPAPSARPRPPTEGPRKSVS-SASEHS 216
            + S P   +     +  SR+   E       + +   S  P  P+    +S S S+++  
Sbjct: 673  EISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQ 732

Query: 217  TTEPSPAARRRP--------SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAH 268
              +  P A + P        SA  G  +  +   + SAT +  P +  P+A   P  P  
Sbjct: 733  MLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAV--PPQGSPTASQAPNQPQA 790

Query: 269  PSQPKPK-------GLQALRPPQV-TPPRKDAAPALGPLSSSPLATPSPSAA---LQSQA 317
            P+ P P         L   RPP    PP     P L PL+ S     +PS A   L  Q 
Sbjct: 791  PTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQG 850

Query: 318  PPTLPATPHSSSLTCQLATPLPLAPPSP-SAPPSLQTLPSPPATPPSQAT--TSLGSPTL 374
            PP     PHS      L  P    PP P   PP      +P  T P+ A   TSL  P  
Sbjct: 851  PPG----PHSLQAGPLLQHP---GPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPAS 903

Query: 375  QATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 434
            Q+       P   PL    P AP  LA+P ++ PP+ P  P L     P+PQA       
Sbjct: 904  QSALQSQQPPREQPL----PPAP--LAMPHIKPPPTTPI-PQL-----PAPQAHKHPPHL 951

Query: 435  LLQAPFSPPPSPPVQAPFSPPASPPVSPSAT--PPSQAPPSLAAPPLQVP-PSPPASPP- 490
               +PFS   + P      PPA  P+S  +T  PPS  PP L   P   P PS PA PP 
Sbjct: 952  SGPSPFSMNANLP-----PPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPG 1006

Query: 491  MSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL 550
            ++ S   P   PPP + PP  L +  PQ P A                  Q PF P    
Sbjct: 1007 LTQSQNLP---PPPASHPPTGLHQVAPQPPFA------------------QHPFVPGGPP 1045

Query: 551  PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPG 610
            P++P   P    PP       Q P S  A+           P P   +    L  A  P 
Sbjct: 1046 PITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPE 1105

Query: 611  PPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL-RGYDS 647
             PPPP RSPS   +  D   H+S +    + L RGY+S
Sbjct: 1106 SPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNS 1143



 Score =  117 bits (292), Expect = 6e-26
 Identities = 139/531 (26%), Positives = 196/531 (36%), Gaps = 99/531 (18%)

Query: 70   IPESAPRAGPTRSAGTSSRNPASRP--PASGRGERAPPAK-----NTSPGPVSSPGRASG 122
            +      A  T S  T ++   SRP  P+ G GE +         ++ P  +    R++ 
Sbjct: 654  VASDTEEADRTSSKKTKTQE-ISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTS 712

Query: 123  TTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA 182
             + P P   +    S  ++ A+ +  +A +  AL A        PT  TP+P+ A     
Sbjct: 713  PSIPSPQDNE----SDSDSSAQQQMLQA-QPPALQA--------PTGVTPAPSSA----P 755

Query: 183  AGT-EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241
             GT ++  P P PSA   PP   P  S +     + T P P    + +     QRP S  
Sbjct: 756  PGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPH 815

Query: 242  LSSSATPLSSPARSGPSARGTPRAPAHPSQPK----PKGLQALR---------PPQVTPP 288
                 +P   P +    + G P AP+H   P     P G  +L+         PPQ    
Sbjct: 816  PPPHPSP-HPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGL 874

Query: 289  RKDAAPALGPLSSSPLAT--------PSPSAALQSQAPPTLPATPHSSSLTCQLATPLPL 340
               A+    PL +SP A         P+  +ALQSQ PP     P           P PL
Sbjct: 875  PPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLP-----------PAPL 923

Query: 341  APPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP-LSPLATPPPQAPPA 399
            A P    PP+   +P  PA    +    L  P+  + ++ LP PP L PL++     PP+
Sbjct: 924  AMPHIKPPPTTP-IPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPS 982

Query: 400  LALPPLQAPPSP---PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP-VQAPFSPP 455
               PPLQ  P     P+SP   P  T S   P   A H         P PP  Q PF P 
Sbjct: 983  AHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPG 1042

Query: 456  ASPPVSPSATPPSQAPP-------------------------SLAAPPLQVP-------- 482
              PP++P   P +  PP                         S   P +Q+         
Sbjct: 1043 GPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAE 1102

Query: 483  -PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 532
             P  P  PP SPS  P     P  A+   +  K   +   + A   L  +P
Sbjct: 1103 EPESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMP 1153



 Score =  115 bits (288), Expect = 2e-25
 Identities = 156/555 (28%), Positives = 211/555 (38%), Gaps = 98/555 (17%)

Query: 225  RRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQ 284
            +++P++  G   P +  + SS        R+ PSA  T    +     K K  + ++   
Sbjct: 589  KKQPASPDGRTSPINEDIRSSG-------RNSPSAASTSSNDSKAETVK-KSAKKVKEEA 640

Query: 285  VTPPRKDAAPALGPLSSSPLA--TPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAP 342
             +P + +        S +  A  T S     Q  + P  P+     S   +       + 
Sbjct: 641  SSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSD 700

Query: 343  PSPSAPPSLQTLPSPPATPP--SQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL 400
            P      +  T PS P+     S + +S     LQA    L +P  + +   P  APP  
Sbjct: 701  PKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAP--TGVTPAPSSAPPGT 758

Query: 401  ALPPLQAP-PSPPASPPL-SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP 458
               P   P PS  A PP  SP A+ +P  P        QAP +P P   +Q   +P   P
Sbjct: 759  PQLPTPGPTPSATAVPPQGSPTASQAPNQP--------QAPTAPVPHTHIQQ--APALHP 808

Query: 459  PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP---QAPPPLAAPPLQLAKP 515
               PS  PP    P    PPLQ P +  A  P +PS   PP   Q PP     P  L   
Sbjct: 809  QRPPSPHPPPHPSPH---PPLQ-PLTGSAGQPSAPSHAQPPLHGQGPPG----PHSL--- 857

Query: 516  PPQAPPALATP-PLQALPSPPASFPGQAPF--SPSASLPMSPLATP----------PPQA 562
              QA P L  P P Q    PP +  GQAP   SP+A+ P + L  P          PP+ 
Sbjct: 858  --QAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPRE 915

Query: 563  PPVLAAPL----LQVPPSPPAS--PTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 616
             P+  APL    ++ PP+ P    P  QA + PP       +SGP    ++    PPPP+
Sbjct: 916  QPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPP------HLSGPS-PFSMNANLPPPPA 968

Query: 617  RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELA------ACHPAA 670
              P S+LS      H  SA   P +L    S P   + A PP   +        A HP  
Sbjct: 969  LKPLSSLS----THHPPSAHPPPLQLMP-QSQPLPSSPAQPPGLTQSQNLPPPPASHPPT 1023

Query: 671  WSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGT 730
                 AP   F   P  P   PP T P              P ++TP  G       PGT
Sbjct: 1024 GLHQVAPQPPFAQHPFVPGGPPPITPPTC------------PSTSTPPAG-------PGT 1064

Query: 731  SGGKAAAGAGAGASS 745
            S     +GA A   S
Sbjct: 1065 SAQPPCSGAAASGGS 1079



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 127/480 (26%), Positives = 166/480 (34%), Gaps = 104/480 (21%)

Query: 14   ARTPAARAPGLLTP----RPPGSPR-PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA 68
            A+ PA +AP  +TP     PPG+P+ P P  TP+A  V                      
Sbjct: 736  AQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAV---------------------- 773

Query: 69   TIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAP---PAKNTSPGPVSSPGRASGTTR 125
                  P+  PT S   +     + P      ++AP   P +  SP P   P        
Sbjct: 774  -----PPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPS------- 821

Query: 126  PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT---PGTPSPAMARRSRA 182
            P P  Q  L  SA +  A   A + P       G     +GP    PG P P        
Sbjct: 822  PHPPLQP-LTGSAGQPSAPSHA-QPPLHGQGPPGPHSLQAGPLLQHPGPPQP-------- 871

Query: 183  AGTEVGLPRPAPSAR----PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPA 238
                 GLP  A   +      P    P  S+   +  S  +     R +P        PA
Sbjct: 872  ----FGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLP------PA 921

Query: 239  SRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP 298
              ++     P ++P    P+ +   + P H S P P  + A  PP          PAL P
Sbjct: 922  PLAMPHIKPPPTTPIPQLPAPQ-AHKHPPHLSGPSPFSMNANLPP---------PPALKP 971

Query: 299  LSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPP 358
            LSS  L+T  P +A     PP L   P S         PLP +P  P      Q LP PP
Sbjct: 972  LSS--LSTHHPPSA----HPPPLQLMPQSQ--------PLPSSPAQPPGLTQSQNLPPPP 1017

Query: 359  ATPPSQATTSLGSPTLQATHSFLPS--PPLSPLATPPPQAPPALALPPLQAPPSPPASPP 416
            A+ P      +      A H F+P   PP++P   P    PP        A P   A PP
Sbjct: 1018 ASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPP--------AGPGTSAQPP 1069

Query: 417  LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAA 476
             S  A          +  L             + P SPP  PP SPS  P     PS A+
Sbjct: 1070 CSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPP-PPPRSPSPEPTVVDTPSHAS 1128



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 69/257 (26%), Positives = 90/257 (35%), Gaps = 69/257 (26%)

Query: 532 PSPPASFPGQAPFSPSASLPMSPLATPPPQAPP-VLAAPLLQVPPSPPASPTLQAPRRPP 590
           PS P+    ++    SA   M     P  QAP  V  AP      +PP +P L      P
Sbjct: 713 PSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAP----SSAPPGTPQL------P 762

Query: 591 TPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPE 650
           TPGP  S +      A+ P   P  S++P+   +      H+    +           P+
Sbjct: 763 TPGPTPSAT------AVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALH-------PQ 809

Query: 651 GGAAASPPPDAELAACHPAAWSRGPAPPL----AFRGAPGAPL-PWPPATGPGSADGLCT 705
              +  PPP       HP+     P PPL       G P AP    PP  G G       
Sbjct: 810 RPPSPHPPP-------HPS-----PHPPLQPLTGSAGQPSAPSHAQPPLHGQGPP----- 852

Query: 706 IYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASV 765
                GP S    P    PGP P   G               P QA  G+ PLG   A+ 
Sbjct: 853 -----GPHSLQAGPLLQHPGP-PQPFG--------------LPPQASQGQAPLGTSPAAA 892

Query: 766 VQHLLSRTLLLAAAEGA 782
             H    +L L A++ A
Sbjct: 893 YPH---TSLQLPASQSA 906


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
            sapiens]
          Length = 1560

 Score =  138 bits (347), Expect = 2e-32
 Identities = 216/842 (25%), Positives = 299/842 (35%), Gaps = 135/842 (16%)

Query: 35   PPPPVTPAALRVLG-AAGAVGRKPLAERA----------GGIGGATIPESAPRAGPTRSA 83
            P  PVT A+  V    AG V +K L+             GG G A+ P   P   P   A
Sbjct: 269  PSEPVTLASAGVSPQGAGLVIQKNLSAAVATTLNGNSVFGGAGAASAPTGTPSGQPLAVA 328

Query: 84   GTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAE-ETV 142
                 +P   P  +    R P      P  V  P     T  P P    G  ++ + E  
Sbjct: 329  PGLGSSPLV-PAPNVILHRTPTPIQPKPAGVLPPKLYQLT--PKPFAPAGATLTIQGEPG 385

Query: 143  ARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMA----RRSRAAGTEVGLPRPAPSARP 198
            A  +  +AP+     A  +   +    G P+PA+     ++  A  T    P+P P A  
Sbjct: 386  ALPQQPKAPQNLTFMAAGKAGQNVVLSGFPAPALQANVFKQPPATTTGAAPPQP-PGALS 444

Query: 199  RPPT-----EG-----PRKSVSSASEHSTTEPSPA-------------------ARRRPS 229
            +P +     +G     P + +           +PA                   A   P 
Sbjct: 445  KPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGAPAVQLPQQLSALPANVGGQILAAAAPH 504

Query: 230  AGGGLQRPASRSLSSSATPLS-----SPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQ 284
             GG L      +  + A PLS     +P     SA     AP    QP    +       
Sbjct: 505  TGGQLIANPILTNQNLAGPLSLGPVLAPHSGAHSAHILSAAPIQVGQPALFQMPVSLAAG 564

Query: 285  VTPPRKDAAPALGPLSSSPL--ATPSPSAALQSQAPPTL--PATPHSSSLTCQLATPLPL 340
              P +   APA GP +++ L   T  PSA      P  L  PATP +++     A P+  
Sbjct: 565  SLPTQSQPAPA-GPAATTVLQGVTLPPSAVAMLNTPDGLVQPATPAAATGE---AAPVLT 620

Query: 341  APPSPSAPPSLQT-----LPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSP-----LA 390
              P+P APP++ T     L  P A  P QA T   +   QAT    PSP L+      + 
Sbjct: 621  VQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTP-QPSPGLASSPEKIVL 679

Query: 391  TPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA 450
              PP A P   L         P      PL+   P      +V +   P +  P+P    
Sbjct: 680  GQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPV 739

Query: 451  PFSPPASPPVSPSATPPSQAPPSLAAPPLQVP-----PSPPASPPM-------SPSATPP 498
                   P    S   P+ AP   AA PL+ P     PS P   P+       SP  T P
Sbjct: 740  AKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRP 799

Query: 499  PQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 558
            P  PP   + P  +++PP +       PPL   P P A      P  P   +  + L  P
Sbjct: 800  PSRPP---SRPQSVSRPPSE-------PPLHPCPPPQA-----PPTLPGIFVIQNQLGVP 844

Query: 559  PPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRS 618
            PP + P   AP    PP PP  P  Q P  P                 L P P  PPS +
Sbjct: 845  PPASNP---APTAPGPPQPPLRPQSQPPEGP-----------------LPPAPHLPPSST 884

Query: 619  PSSTLSGPDLAGHSSSATSTPEELRGYDS-GPEGGAAASPPPDAELAACHPAAWSRGPAP 677
             S+  S  + +    + T +  +L+   S GP    + +PPP   L    P   +  P P
Sbjct: 885  SSAVASSSETSSRLPAPTPSDFQLQFPPSQGPH--KSPTPPPTLHLV---PEPAAPPPPP 939

Query: 678  PLAFR--GAPGAPLPWPPA---TGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTS- 731
            P  F+    P   LP P A          G+    +  G  +A     +L P  SP  S 
Sbjct: 940  PRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPAASV 999

Query: 732  --GGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGG 789
               G+A +G    A S +P  A +    L  L  +  +   S    L  A+ A+ G G  
Sbjct: 1000 LVSGQAPSGTPT-APSHAPAPAPMAATGLPPLLPAENKAFASNLPTLNVAKAASSGPGKP 1058

Query: 790  PG 791
             G
Sbjct: 1059 SG 1060



 Score =  138 bits (347), Expect = 2e-32
 Identities = 192/700 (27%), Positives = 258/700 (36%), Gaps = 118/700 (16%)

Query: 15   RTPAARAPGLLTPRPPGSPRPPPPV----------------TPAALRVL--GAAGAVGRK 56
            + P A   G   P+PPG+   P  V                 P   + L  GA      +
Sbjct: 425  KQPPATTTGAAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGAPAVQLPQ 484

Query: 57   PLAERAGGIGGATIPESAPRAGPTRSAGTSSRN-----PASRPPASGRGERAPPAKNTSP 111
             L+     +GG  +  +AP  G    A     N     P S  P       A  A   S 
Sbjct: 485  QLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAGPLSLGPVLAPHSGAHSAHILSA 544

Query: 112  GPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGT 171
             P+   G+ +    P  L    L   ++   A   AT   +   L   A    + P  G 
Sbjct: 545  API-QVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPSAVAMLNTP-DGL 602

Query: 172  PSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAG 231
              PA    +      V   +PAP A P   T  P       ++     P+P A   P A 
Sbjct: 603  VQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQAT 662

Query: 232  GGLQRPASRSLSSSATPLSSPARSGPSARGTPRA-----PAHPSQP--KPKGLQALRPPQ 284
                 P   S S     L  P  + P+A  T  +     P   SQ     +G     P  
Sbjct: 663  TPQPSPGLAS-SPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPAS 721

Query: 285  V----TPPRKDAAPA--------LGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTC 332
            V     PP +D APA        LGP +    A+P+P+  + + AP   P    S SL  
Sbjct: 722  VIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPH 781

Query: 333  QLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATP 392
            Q   PL  +P  PS  P+      PP+ PPS+  +    P+          PPL P   P
Sbjct: 782  Q--APLGDSPHLPSPHPT-----RPPSRPPSRPQSVSRPPS---------EPPLHP--CP 823

Query: 393  PPQAPPALA---LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ 449
            PPQAPP L    +   Q    PPAS P +P A   PQ P       L+    PP  P   
Sbjct: 824  PPQAPPTLPGIFVIQNQLGVPPPASNP-APTAPGPPQPP-------LRPQSQPPEGPLPP 875

Query: 450  APFSPPA--SPPVSPSATPPSQAP-PSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA 506
            AP  PP+  S  V+ S+   S+ P P+ +   LQ PPS    P  SP+  P     P  A
Sbjct: 876  APHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPPS--QGPHKSPTPPPTLHLVPEPA 933

Query: 507  APPLQLAKPPPQAPPALATPPLQALPSPPA---------------SFPGQAPFSPSASLP 551
            APP     PPP     + T P  ALP P A               +  G AP +P  S  
Sbjct: 934  APP-----PPPPRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQTSTS 988

Query: 552  MSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGP 611
            + PL +P        AA +L    +P  +PT  AP   P P P  +   P L        
Sbjct: 989  LGPLTSP--------AASVLVSGQAPSGTPT--APSHAPAPAPMAATGLPPLL------- 1031

Query: 612  PPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 651
             P  +++ +S L   ++A  +SS    P  L+ Y+S   G
Sbjct: 1032 -PAENKAFASNLPTLNVAKAASSGPGKPSGLQ-YESKLSG 1069



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 207/865 (23%), Positives = 281/865 (32%), Gaps = 218/865 (25%)

Query: 18   AARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRA 77
            +A  P L  P       PPP   PA    +     +G +    +A       IP +AP  
Sbjct: 710  SAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLK 769

Query: 78   GPTRSAGTS-----------------SRNPASRPPASGRGERAPPAK---NTSPGPVSSP 117
            GP  S+  S                    P SRPP+  +    PP++   +  P P + P
Sbjct: 770  GPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPP 829

Query: 118  GRASGTTRPGPL---GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP-- 172
                  T PG      Q G+   A            P     S    +   GP P  P  
Sbjct: 830  ------TLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQS----QPPEGPLPPAPHL 879

Query: 173  SPAMARRSRAAGTEVG--LPRPAPS--ARPRPPTEGPRKSVS------------------ 210
             P+    + A+ +E    LP P PS      PP++GP KS +                  
Sbjct: 880  PPSSTSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKSPTPPPTLHLVPEPAAPPPPP 939

Query: 211  SASEHSTTEPSPAARR-----------------RPSAGGGLQRPASRSLSSSATPLSSPA 253
              +    T P PA  +                 +  AGG    PA+   S+S  PL+SPA
Sbjct: 940  PRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGA---PAAPQTSTSLGPLTSPA 996

Query: 254  R----SGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSP 309
                 SG +  GTP AP+H   P P     L PP +    K  A  L  L+ +  A+  P
Sbjct: 997  ASVLVSGQAPSGTPTAPSHAPAPAPMAATGL-PPLLPAENKAFASNLPTLNVAKAASSGP 1055

Query: 310  S--AALQSQA-------PPTLPATPHSSSLT-CQLATPLPLAPPSPSAPPSLQ------- 352
               + LQ ++       PPTL  +  +  L          L P   +A PS +       
Sbjct: 1056 GKPSGLQYESKLSGLKKPPTLQPSKEACFLEHLHKHQGSVLHPDYKTAFPSFEDALHRLL 1115

Query: 353  -------TLPSP-PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPA----- 399
                    LPSP       +   ++ +  L+ T + L    L  L      +P A     
Sbjct: 1116 PYHVYQGALPSPSDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLEESRRVSPSAEMVMI 1175

Query: 400  -----------LALPPLQAPPSPPASPPLS-----PLATPSP----QAPNALAVHLLQAP 439
                       LAL    A   P      S     P+A  S          L+     A 
Sbjct: 1176 DRMFIQEEKTTLALDKQLAKEKPDEYVSSSRSLGLPIAASSEGHRLPGHGPLSSSAPGAS 1235

Query: 440  FSPPPSPPVQ-------APFSPP-----ASPPVSPSATPPSQAP----------PSLAAP 477
              PPP  P +       A  SP      AS  +S S++  S A           PS   P
Sbjct: 1236 TQPPPHLPTKLVIRHGGAGGSPSVTWARASSSLSSSSSSSSAASSLDADEDGPMPSRNRP 1295

Query: 478  P-------------LQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALA 524
            P             L++      S  +  +A  P   PPP  A  L++A+PPP+ PP   
Sbjct: 1296 PIKTYEARSRIGLKLKIKQEAGLSKVVHNTALDPVHQPPPPPA-TLKVAEPPPRPPPP-- 1352

Query: 525  TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQV-------PPSP 577
                   P P     G     P A+    PL T    AP     PL +        P +P
Sbjct: 1353 -------PPPTGQMNGTVDHPPPAAPERKPLGT----APHCPRLPLRKTYRENVGGPGAP 1401

Query: 578  PASPTLQAPRRPPTPGP---DTSVSGPRLTLA---------LAPGPPPPPSRSPSSTLSG 625
              +P  +A    P P P   D + SG    LA         +  GPPP P+ S +     
Sbjct: 1402 EGTPAGRARGGSPAPLPAKVDEATSGLIRELAAVEDELYQRMLKGPPPEPAASAAQGTGD 1461

Query: 626  PDLAGHSSSATSTPEELRGYDSGPEGGAAA----SPPPDAELAACHPA---------AWS 672
            PD       A   P   R     P+   A+    SP  D        A         A  
Sbjct: 1462 PDW-----EAPGLPPAKRRKSESPDVDQASFSSDSPQDDTLTEHLQSAIDSILNLQQAPG 1516

Query: 673  RGPAPPLAFRGAPGAPLPWPPATGP 697
            R PAP      + G P   PP   P
Sbjct: 1517 RTPAPSYPHAASAGTPASPPPLHRP 1541



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 205/874 (23%), Positives = 295/874 (33%), Gaps = 144/874 (16%)

Query: 4    KRDKAKAGAAARTPAARAPG-LLTPRP-PG---SPRP-----PPPVTPAALRVLGAAGAV 53
            ++ +A+    A TP A AP    TP+P PG   SP       PP  TP A+    +    
Sbjct: 640  QQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMF 699

Query: 54   GRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPAS---GRGERAPPAKNT- 109
              +  +++     G   P  +  A    SA   +++PA   P +   G G +AP ++ + 
Sbjct: 700  LPQERSQQPLSAEG---PHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASP 756

Query: 110  -------SPGPVSSPGRASGTTRP--GPLGQKGLRISAEETVARGKATEAPKRSALSAGA 160
                   +  P+  PG +S  + P   PLG      S   T    +    P+  ++S   
Sbjct: 757  APAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQ--SVSRPP 814

Query: 161  RRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEP 220
                  P P   +P           ++G+P PA  + P P   GP +            P
Sbjct: 815  SEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPA--SNPAPTAPGPPQPPLRPQSQPPEGP 872

Query: 221  SPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQAL 280
             P A   P +       A  S S +++ L +P  S    +  P    H S   P  L  +
Sbjct: 873  LPPAPHLPPSSTS---SAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKSPTPPPTLHLV 929

Query: 281  RPPQVTPPRKDAAPALGPLSSSPL-ATPSPSAALQS--QAPPTL---------PATPHSS 328
              P   PP     P    + ++P  A P P A L+   Q P  +         PA P +S
Sbjct: 930  PEPAAPPP---PPPRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQTS 986

Query: 329  SLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH----SFLPSP 384
            +    L +P      S  AP    T PS    P   A T L  P L A +    S LP+ 
Sbjct: 987  TSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPAPMAATGL-PPLLPAENKAFASNLPTL 1045

Query: 385  PLSPLATPPPQAPPALA----LPPLQAPPSPPASPPLSPLA---------------TPSP 425
             ++  A+  P  P  L     L  L+ PP+   S     L                T  P
Sbjct: 1046 NVAKAASSGPGKPSGLQYESKLSGLKKPPTLQPSKEACFLEHLHKHQGSVLHPDYKTAFP 1105

Query: 426  QAPNAL----AVHLLQAPF-SPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ 480
               +AL      H+ Q    SP     V   F   ++  +  +    ++    L     +
Sbjct: 1106 SFEDALHRLLPYHVYQGALPSPSDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLEESRR 1165

Query: 481  VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQ----APPALATPPLQALPSPPA 536
            V PS      M        Q      A   QLAK  P     +  +L  P   A  S   
Sbjct: 1166 VSPSAE----MVMIDRMFIQEEKTTLALDKQLAKEKPDEYVSSSRSLGLPI--AASSEGH 1219

Query: 537  SFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT 596
              PG  P S SA     P A+  P  PP L   L+        SP++   R   +    +
Sbjct: 1220 RLPGHGPLSSSA-----PGASTQP--PPHLPTKLVIRHGGAGGSPSVTWARASSSLSSSS 1272

Query: 597  SVSGPRLTL-ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAA 655
            S S    +L A   GP P  +R P  T                      Y++    G   
Sbjct: 1273 SSSSAASSLDADEDGPMPSRNRPPIKT----------------------YEARSRIGLKL 1310

Query: 656  SPPPDAELA-ACHPAAWS---RGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEG 711
                +A L+   H  A     + P PP   + A   P P PP    G  +G         
Sbjct: 1311 KIKQEAGLSKVVHNTALDPVHQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAA 1370

Query: 712  PE---------------SATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGEL 756
            PE                 T       PG   GT  G+A  G      S +P  A++ E 
Sbjct: 1371 PERKPLGTAPHCPRLPLRKTYRENVGGPGAPEGTPAGRARGG------SPAPLPAKVDEA 1424

Query: 757  PLGALQ--ASVVQHLLSRTLLLAAAEGAAGGSGG 788
              G ++  A+V   L  R L     E AA  + G
Sbjct: 1425 TSGLIRELAAVEDELYQRMLKGPPPEPAASAAQG 1458



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 99/381 (25%), Positives = 133/381 (34%), Gaps = 108/381 (28%)

Query: 182  AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSP-----AARRRPSAGGG--- 233
            ++   +GLP  A S   R P  GP   +SS++  ++T+P P        R   AGG    
Sbjct: 1203 SSSRSLGLPIAASSEGHRLPGHGP---LSSSAPGASTQPPPHLPTKLVIRHGGAGGSPSV 1259

Query: 234  LQRPASRSLSSSATPLSS------------PARSGPSAR--------------------- 260
                AS SLSSS++  S+            P+R+ P  +                     
Sbjct: 1260 TWARASSSLSSSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLS 1319

Query: 261  ----GTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQ 316
                 T   P H   P P  L+   PP   PP                  P P+  +   
Sbjct: 1320 KVVHNTALDPVHQPPPPPATLKVAEPPPRPPP-----------------PPPPTGQMNGT 1362

Query: 317  APPTLPATPHSSSL-TCQLATPLPL---------APPSPSAPPSLQTLPSPPATPPS--- 363
                 PA P    L T      LPL          P +P   P+ +     PA  P+   
Sbjct: 1363 VDHPPPAAPERKPLGTAPHCPRLPLRKTYRENVGGPGAPEGTPAGRARGGSPAPLPAKVD 1422

Query: 364  QATT----SLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPA------ 413
            +AT+     L +   +     L  PP  P A+    A      P  +AP  PPA      
Sbjct: 1423 EATSGLIRELAAVEDELYQRMLKGPPPEPAAS----AAQGTGDPDWEAPGLPPAKRRKSE 1478

Query: 414  SPPL--SPLATPSPQAPNALAVH----------LLQAP-FSPPPSPPVQAPFSPPASPPV 460
            SP +  +  ++ SPQ  + L  H          L QAP  +P PS P  A    PASPP 
Sbjct: 1479 SPDVDQASFSSDSPQ-DDTLTEHLQSAIDSILNLQQAPGRTPAPSYPHAASAGTPASPPP 1537

Query: 461  --SPSATPPSQAPPSLAAPPL 479
               P A PPS     L A  L
Sbjct: 1538 LHRPEAYPPSSHNGGLGARTL 1558



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 101/396 (25%), Positives = 129/396 (32%), Gaps = 84/396 (21%)

Query: 13   AARTPAARAPGL--LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATI 70
            AA +   R PG   L+   PG+   PPP  P  L +              R GG GG+  
Sbjct: 1213 AASSEGHRLPGHGPLSSSAPGASTQPPPHLPTKLVI--------------RHGGAGGSPS 1258

Query: 71   PESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLG 130
               A RA  + S+ +SS + AS   A   G    P++N  P                   
Sbjct: 1259 VTWA-RASSSLSSSSSSSSAASSLDADEDGPM--PSRNRPP------------------- 1296

Query: 131  QKGLRISAEETVAR-GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL 189
                 I   E  +R G   +  + + LS         P    P P        A  +V  
Sbjct: 1297 -----IKTYEARSRIGLKLKIKQEAGLSKVVHNTALDPVHQPPPP-------PATLKVAE 1344

Query: 190  PRPAPSARP-----------RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQR-- 236
            P P P   P            PP   P +     + H    P     R    G G     
Sbjct: 1345 PPPRPPPPPPPTGQMNGTVDHPPPAAPERKPLGTAPHCPRLPLRKTYRENVGGPGAPEGT 1404

Query: 237  PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPP-------QVTPPR 289
            PA R+   S  PL  PA+   +  G  R  A       + +    PP       Q T   
Sbjct: 1405 PAGRARGGSPAPL--PAKVDEATSGLIRELAAVEDELYQRMLKGPPPEPAASAAQGTGDP 1462

Query: 290  KDAAPALGPLSSSPLATPS-PSAALQSQAPPTLPATPH-----SSSLTCQLA---TPLPL 340
               AP L P       +P    A+  S +P     T H      S L  Q A   TP P 
Sbjct: 1463 DWEAPGLPPAKRRKSESPDVDQASFSSDSPQDDTLTEHLQSAIDSILNLQQAPGRTPAPS 1522

Query: 341  APPSPSA--PPSLQTLPSPPATPPSQATTSLGSPTL 374
             P + SA  P S   L  P A PPS     LG+ TL
Sbjct: 1523 YPHAASAGTPASPPPLHRPEAYPPSSHNGGLGARTL 1558



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 90/388 (23%), Positives = 123/388 (31%), Gaps = 81/388 (20%)

Query: 143  ARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPT 202
            A  +    P    LS+ A   ++ P P  P+  + R   A G+          AR     
Sbjct: 1214 ASSEGHRLPGHGPLSSSAPGASTQPPPHLPTKLVIRHGGAGGSP-----SVTWARASSSL 1268

Query: 203  EGPRKSVSSASEHSTTEPSPA-ARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARG 261
                 S S+AS     E  P  +R RP     ++   +RS       +   A        
Sbjct: 1269 SSSSSSSSAASSLDADEDGPMPSRNRPP----IKTYEARSRIGLKLKIKQEAGLSKVVHN 1324

Query: 262  TPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTL 321
            T   P H   P P  L+   PP   PP                  P P+  +        
Sbjct: 1325 TALDPVHQPPPPPATLKVAEPPPRPPP-----------------PPPPTGQMNGTVDHPP 1367

Query: 322  PATPHSSSL-TCQLATPLPL---------APPSPSAPPSLQTLPSPPATPPS---QATTS 368
            PA P    L T      LPL          P +P   P+ +     PA  P+   +AT+ 
Sbjct: 1368 PAAPERKPLGTAPHCPRLPLRKTYRENVGGPGAPEGTPAGRARGGSPAPLPAKVDEATSG 1427

Query: 369  L----GSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPA------SPPL- 417
            L     +   +     L  PP  P A+    A      P  +AP  PPA      SP + 
Sbjct: 1428 LIRELAAVEDELYQRMLKGPPPEPAAS----AAQGTGDPDWEAPGLPPAKRRKSESPDVD 1483

Query: 418  -SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAA 476
             +  ++ SPQ  + L  HL  A                        S     QAP    A
Sbjct: 1484 QASFSSDSPQ-DDTLTEHLQSA----------------------IDSILNLQQAPGRTPA 1520

Query: 477  PPLQVPPSPPASPPMSPSATPPPQAPPP 504
            P    P +  A  P SP     P+A PP
Sbjct: 1521 P--SYPHAASAGTPASPPPLHRPEAYPP 1546


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score =  137 bits (345), Expect = 4e-32
 Identities = 168/600 (28%), Positives = 218/600 (36%), Gaps = 102/600 (17%)

Query: 169 PGTPSPAMARRSRAAGTEV--GLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR 226
           P TP    A  + A G  V  G P  A  A P  P EG        +  +  EP PA R 
Sbjct: 45  PRTPE-VRAAAAGALGNHVVSGSPAGAAGAGPAAPAEG--------APGAAPEPPPAGRA 95

Query: 227 RPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVT 286
           RP  GG                   P R GP +   P  PA P+ P  K    LRPP   
Sbjct: 96  RPGGGG-------------------PQRPGPPSPRRPLVPAGPAPPAAK----LRPP--- 129

Query: 287 PPRKDAAPALGPLSSSPLATPSPSAALQSQAP---PTLPATPHSSSLTCQLATPLPLAPP 343
                      P  S+    P P+AA  +  P   P  PA P   +     A P P   P
Sbjct: 130 -----------PEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGP 178

Query: 344 SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSP------PLSPLATPPPQAP 397
            P   P     P  PA P +  T +  +  L + H+  P+       P + L  P P AP
Sbjct: 179 GPGPGPG----PGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAP 234

Query: 398 -PALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA-PFSPP 455
              +  PP     +PPA    SP A P+P AP A       AP  PPP+P   A P   P
Sbjct: 235 GTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAA-------APPPPPPAPATLARPPGHP 287

Query: 456 ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKP 515
           A PP +  A PP  A  +  +      P+P A  P   S  P P A     AP ++   P
Sbjct: 288 AGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESP 347

Query: 516 PPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL---ATPPPQAPPVLAAPLLQ 572
                       +QA P    +     P S +AS+ + P    A P P A P  A     
Sbjct: 348 ---------KRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPT 398

Query: 573 VPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTL---ALAPGPPPPPSRSPSSTLSGPDLA 629
             P   A    Q+  R PT     + SG R TL    LAP  P PP ++P++  +     
Sbjct: 399 GLPKGAAGAVTQSLSRTPT----ATTSGIRATLTPTVLAPRLPQPP-QNPTNIQNFQLPP 453

Query: 630 GHSSSATSTPEELR-GYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAP 688
           G     +   + L     +  +  A A   P   +A   PA  +  P   ++   APG P
Sbjct: 454 GMVLVRSENGQLLMIPQQALAQMQAQAHAQPQTTMAP-RPATPTSAPPVQISTVQAPGTP 512

Query: 689 LPWPPATGPGSADGLCTIYETEGPESATPAPGAL---DPGPSPGTSGGKAAAGAGAGASS 745
           +     T         TI +       T  P A     PG  P    G AA  A  G ++
Sbjct: 513 IIARQVTP-------TTIIKQVSQAQTTVQPSATLQRSPGVQPQLVLGGAAQTASLGTAT 565



 Score =  114 bits (286), Expect = 3e-25
 Identities = 153/559 (27%), Positives = 198/559 (35%), Gaps = 95/559 (16%)

Query: 37  PPVTPAALRVLG-------AAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRN 89
           P V  AA   LG        AGA G  P A   G  G A  P  A RA P          
Sbjct: 48  PEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGP 107

Query: 90  PASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATE 149
           P+ R P    G   P AK                 RP P G            + G    
Sbjct: 108 PSPRRPLVPAGPAPPAAK----------------LRPPPEG------------SAGSCAP 139

Query: 150 APKRSALSAGARRDTSGPT-PGTPSPAMARRSRAAGTEVGLPRPAPS-ARPRPPTEGPRK 207
            P  +A++AG     +GP  P  P+   AR     G   G P P P   +P  P      
Sbjct: 140 VPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPG-PGPGPGPGKPAGPGAAQTL 198

Query: 208 SVSSA---SEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPR 264
           + S+A   S H+           P+A   L +PA+       T + +P   G +A   P 
Sbjct: 199 NGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAA-----PGTVIQTPPFVGAAAPPAPA 253

Query: 265 APAHPSQPKPKGLQALRPPQVTPPRKDAAPA---LGPLSSSPLATPSPSAALQ----SQA 317
           AP+ P+ P P    A  PP    P   A P     GP +++P A P P+AA        A
Sbjct: 254 APSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAP-AVPPPAAAQNGGSAGAA 312

Query: 318 PPTLPATPHSSSLTCQLATPLPLAPPSP------------SAPPSLQTLPSPPATPPSQA 365
           P   PA    + ++ Q       A P+P            +APP+ QTL +  + P S A
Sbjct: 313 PAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAA--SGPASTA 370

Query: 366 TTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPS- 424
            + +  PT+Q     LPSP     A  PP AP      P  A  +   S   +P AT S 
Sbjct: 371 ASMVIGPTMQGA---LPSP-----AAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSG 422

Query: 425 ---PQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV 481
                 P  LA  L Q P +P      Q P          P           L   P Q 
Sbjct: 423 IRATLTPTVLAPRLPQPPQNPTNIQNFQLP----------PGMVLVRSENGQLLMIPQQA 472

Query: 482 PPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQ 541
                A     P  T  P+   P +APP+Q++       P +A    Q  P+       Q
Sbjct: 473 LAQMQAQAHAQPQTTMAPRPATPTSAPPVQISTVQAPGTPIIAR---QVTPTTIIKQVSQ 529

Query: 542 A--PFSPSASLPMSPLATP 558
           A     PSA+L  SP   P
Sbjct: 530 AQTTVQPSATLQRSPGVQP 548



 Score =  108 bits (269), Expect = 3e-23
 Identities = 110/371 (29%), Positives = 139/371 (37%), Gaps = 24/371 (6%)

Query: 393 PPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF 452
           P  A  A    P +  P     PP +  A P    P        + P  P    P  A  
Sbjct: 67  PAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKL 126

Query: 453 SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQL 512
            PP        A  P+ A  +    P    P+ PA P    +   P   P P   P    
Sbjct: 127 RPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGP 186

Query: 513 AKPPPQAPPALATPPLQALPSPPASFPGQAPFS--PSASLPMSPLATPPP--QAPPVL-- 566
            KP               L S  A+ P  +  +  P+A LP+   A P    Q PP +  
Sbjct: 187 GKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGA 246

Query: 567 AAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPG-PPPPPSRSPSSTLSG 625
           AAP     PSPPA+P   AP   P P P         TLA  PG P  PP+ +P+     
Sbjct: 247 AAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPA-----TLARPPGHPAGPPTAAPAVPPPA 301

Query: 626 PDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAP 685
               G S+ A   P    G   GP  G +  P P A  AA  PA   +  +P    + AP
Sbjct: 302 AAQNGGSAGAAPAPAPAAG---GP-AGVSGQPGPGA--AAAAPAPGVKAESPKRVVQAAP 355

Query: 686 GAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGG--KAAAGAGAGA 743
            A      A+GP S      I  T   + A P+P A+ P P+PGT  G  K AAGA   +
Sbjct: 356 PAAQTL-AASGPASTAASMVIGPT--MQGALPSPAAVPP-PAPGTPTGLPKGAAGAVTQS 411

Query: 744 SSRSPKQARLG 754
            SR+P     G
Sbjct: 412 LSRTPTATTSG 422



 Score =  107 bits (266), Expect = 6e-23
 Identities = 146/518 (28%), Positives = 183/518 (35%), Gaps = 79/518 (15%)

Query: 8   AKAGAAARTPAARA-PGLLTPRPPGSPRPPPPVT------PAA-LR--VLGAAGAVGRKP 57
           A   A    PA RA PG   P+ PG P P  P+       PAA LR    G+AG+    P
Sbjct: 82  APGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVP 141

Query: 58  LAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSP 117
            A        A  PE AP AGP + AG     PA+    +G G    P     PGP    
Sbjct: 142 AAAAV-----AAGPEPAP-AGPAKPAG-----PAALAARAGPGPGPGPGPGPGPGPGKPA 190

Query: 118 GRASGTTRPGP---LGQKGLRISAEETVARGKATEAPKRSALSAGARRDT-------SGP 167
           G  +  T  G    L        A   V  G A   P     + G    T       + P
Sbjct: 191 GPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPP 250

Query: 168 TPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR 227
            P  PSP  A    A       P PAP+   RPP             H    P+ A    
Sbjct: 251 APAAPSPPAAPAPAAPAAAPPPPPPAPATLARPP------------GHPAGPPTAAPAVP 298

Query: 228 PSAGGGLQRPASRSLSSSATPLSSPARSGP---SARGTPRAPAHPSQPKPKGLQALRPPQ 284
           P A       A    S+ A P  +PA  GP   S +  P A A    P  K     R  Q
Sbjct: 299 PPAA------AQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQ 352

Query: 285 VTPPRKDAAPALGPLS--SSPLATPSPSAALQSQA--PPTLPATPHSSSLTCQLATPLPL 340
             PP      A GP S  +S +  P+   AL S A  PP  P T              P 
Sbjct: 353 AAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGT--------------PT 398

Query: 341 APPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL 400
             P  +A    Q+L   P    S    +L +PT+ A    LP PP +P      Q PP +
Sbjct: 399 GLPKGAAGAVTQSLSRTPTATTSGIRATL-TPTVLAPR--LPQPPQNPTNIQNFQLPPGM 455

Query: 401 ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ-APFSPPASPP 459
            L  +++        P   LA    QA       +   P +P  +PPVQ +    P +P 
Sbjct: 456 VL--VRSENGQLLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPVQISTVQAPGTPI 513

Query: 460 VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATP 497
           ++   TP +       A   Q    P A+   SP   P
Sbjct: 514 IARQVTPTTIIKQVSQA---QTTVQPSATLQRSPGVQP 548



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 96/339 (28%), Positives = 122/339 (35%), Gaps = 49/339 (14%)

Query: 482 PPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP---PQ--APPALATPPLQALPSPPA 536
           P     + P +P+   P  AP P   PP   A+P    PQ   PP+   P + A P+PPA
Sbjct: 67  PAGAAGAGPAAPAEGAPGAAPEP---PPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPA 123

Query: 537 SFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPL-LQVPPSPPASPTLQAPRRPPTPGPD 595
           +     P   + S        P P A  V A P      P+ PA P   A R  P PGP 
Sbjct: 124 AKLRPPPEGSAGS------CAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPG 177

Query: 596 TSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPE----- 650
               GP       PGP  P     + TL+G     +S  A +    L   ++GP      
Sbjct: 178 PG-PGP------GPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSL--VNNGPAALLPL 228

Query: 651 ------GGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLC 704
                 G    +PP     A   PAA    P+PP A   AP AP   PP   P  A    
Sbjct: 229 PKPAAPGTVIQTPPFVGAAAPPAPAA----PSPPAA--PAPAAPAAAPPPPPPAPATLAR 282

Query: 705 TIYETEGPESATPA---PGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGAL 761
                 GP +A PA   P A   G S G +   A A  G    S  P        P   +
Sbjct: 283 PPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGV 342

Query: 762 QASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTG 800
           +A   + ++      AA   A   +  GP       V G
Sbjct: 343 KAESPKRVVQ-----AAPPAAQTLAASGPASTAASMVIG 376



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 138/595 (23%), Positives = 193/595 (32%), Gaps = 124/595 (20%)

Query: 10  AGAAARTPAARAPGLLTPRPPGSPRPPPPVTPA-----ALRVLGAAGAV-GRKPLAERAG 63
           A AAA  P   AP  L  RPPG P  PP   PA     A +  G+AGA     P A    
Sbjct: 265 APAAAPPPPPPAPATLA-RPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPA 323

Query: 64  GIGGATIPESAPRA-GPTRSAGTSSRNPASRPPA------SGRGERA------PPAKNTS 110
           G+ G   P +A  A  P   A +  R   + PPA      SG    A      P  +   
Sbjct: 324 GVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGAL 383

Query: 111 PGPVSSPGRASGTTRPGPLGQ----------------KGLRISAEETVARGKATEAPKRS 154
           P P + P  A GT    P G                  G+R +   TV   +  + P+  
Sbjct: 384 PSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNP 443

Query: 155 ALSAGAR--------RDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPR 206
                 +        R  +G     P  A+A+    A  +   P+   + RP  PT  P 
Sbjct: 444 TNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQAHAQ---PQTTMAPRPATPTSAPP 500

Query: 207 KSVSS----------------------ASEHSTTEPSPAARRRPSAG-----GGLQRPAS 239
             +S+                      +   +T +PS   +R P        GG  + AS
Sbjct: 501 VQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPSATLQRSPGVQPQLVLGGAAQTAS 560

Query: 240 RSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPL 299
              +++A    +P R+ P A  T  A     +   K              K+    L  L
Sbjct: 561 LG-TATAVQTGTPQRTVPGATTTSSAATETMENVKKC-------------KNFLSTLIKL 606

Query: 300 SSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQL-----ATPLPLAPP----------- 343
           +SS   +   +A ++      L     +   T +L     ++P P   P           
Sbjct: 607 ASSGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQ 666

Query: 344 -SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALAL 402
            +P +   +Q     P  P SQATT+L +  L +  S   +   +         PP L+L
Sbjct: 667 LTPDSAAFIQQSQQQPPPPTSQATTALTAVVLSS--SVQRTAGKTAATVTSALQPPVLSL 724

Query: 403 -PPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 461
             P Q        P  +PL    P  P AL          PP     Q P      P   
Sbjct: 725 TQPTQVGVGKQGQP--TPLVIQQPPKPGAL--------IRPPQVTLTQTPMVALRQPHNR 774

Query: 462 PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP 516
              T P Q    +   PLQ  P P   P + P            AA      K P
Sbjct: 775 IMLTTPQQ----IQLNPLQ--PVPVVKPAVLPGTKALSAVSAQAAAAQKNKLKEP 823



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 91/320 (28%), Positives = 107/320 (33%), Gaps = 40/320 (12%)

Query: 499 PQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 558
           P+ P   AA    L        PA A     A P+  A  PG AP  P A         P
Sbjct: 45  PRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGA--PGAAPEPPPAGRARPGGGGP 102

Query: 559 PPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRS 618
               PP    PL+   P+PPA     A  RPP  G   S +      A+A GP P P+  
Sbjct: 103 QRPGPPSPRRPLVPAGPAPPA-----AKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPA-G 156

Query: 619 PSSTLSGPDLAGHSSSATST-----PEELRGYDSGPEGGAAASPPPDAELAACHPAAW-- 671
           P+       LA  +           P    G  +GP  GAA +    A L   H AA   
Sbjct: 157 PAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGP--GAAQTLNGSAALLNSHHAAAPA 214

Query: 672 ----SRGPAP--PLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPG 725
               + GPA   PL    APG  +  PP  G  +            P  A PA     P 
Sbjct: 215 VSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPP 274

Query: 726 PSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGG 785
           P+P T        AG       P  A     P  A Q              A A  A   
Sbjct: 275 PAPATLARPPGHPAG-------PPTAAPAVPPPAAAQNGGS----------AGAAPAPAP 317

Query: 786 SGGGPGGAEGGGVTGGARAA 805
           + GGP G  G    G A AA
Sbjct: 318 AAGGPAGVSGQPGPGAAAAA 337



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 59/184 (32%), Positives = 64/184 (34%), Gaps = 33/184 (17%)

Query: 629 AGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAP 688
           A H   A  TPE +R   +G  G    S  P     A        GPA P    GAPGA 
Sbjct: 38  AHHHHLAPRTPE-VRAAAAGALGNHVVSGSPAGAAGA--------GPAAPA--EGAPGAA 86

Query: 689 LPWPPATGPGSADGLCTIYETEGPES-------ATPAPGALDPGPSPGTSGGKAAAGAGA 741
            P PP  G     G     +  GP S       A PAP A    P P  S G  A    A
Sbjct: 87  -PEPPPAGRARPGGGGP--QRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAA 143

Query: 742 GASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGG 801
            A +  P+ A  G        A            LAA  G   G G GPG   G G   G
Sbjct: 144 AAVAAGPEPAPAGPAKPAGPAA------------LAARAGPGPGPGPGPGPGPGPGKPAG 191

Query: 802 ARAA 805
             AA
Sbjct: 192 PGAA 195


>gi|239752594 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 673

 Score =  133 bits (335), Expect = 6e-31
 Identities = 177/690 (25%), Positives = 253/690 (36%), Gaps = 107/690 (15%)

Query: 15  RTPAARAP------GLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA 68
           RTP+  +P        LT  P  +     P T + +     A   G  P A   G    A
Sbjct: 6   RTPSRASPTRTPSTASLTGTPSRASLTGTPSTASLMGTPSRASLTGTPPRASLKGTTSMA 65

Query: 69  TIPESAPRAGPTRSAGTS--SRNPASR-----PPASGRGERAPPA----KNTSPGPVSSP 117
           ++  S  RA  TR   +S  +R P+       PP + R    P A    + ++     SP
Sbjct: 66  SLMVSPSRASLTRMQSSSLLTRTPSMASLKRMPPRASRTRTLPRASLMRRPSTASLTRSP 125

Query: 118 GRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMA 177
            RAS TT P        R S   T +   A   P R++L+   R         TPS A  
Sbjct: 126 SRASLTTTPS-------RASLSMTPSTAAALTMPSRASLT---RTPPRASLTMTPSTASL 175

Query: 178 RRSRAAGTEVGLP-RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQR 236
            R+    +  G+P R +P+  P   +     S +S +   +         R S  G   R
Sbjct: 176 TRTPPRASPTGMPSRTSPTGMPSTASLTKMDSTASITRTLSRASPTGTPPRASPTGSPPR 235

Query: 237 PASRSLSSSATPLSSPARSGP-------------SARGTPRAPAHPSQPKPKGLQALRPP 283
            +   + S+A  + +P R+ P             S     R P+ PS   P G  +    
Sbjct: 236 ASLSMMPSTALLIRTPPRASPTGMLSRTSLTKMDSTASITRTPSRPSTASPTGTPSRASL 295

Query: 284 QVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPP 343
            +TP        L    +SP    S ++  +  +  ++  TP  +S+T   +   P   P
Sbjct: 296 SMTPSTASLMRMLP--RASPTGMLSRTSLTKMDSTASISRTPPRASITRTPSRASPTGKP 353

Query: 344 SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP-LSPLATP--------PP 394
           S ++P    +  SP  +P + + T L S     T S   +PP  SP  TP        PP
Sbjct: 354 STASPTGTPSRASPTGSPSTASLTGLSS-----TASPTGTPPRASPTGTPSTASLTRKPP 408

Query: 395 QAPPALALP------------PLQAPP--SPPASPP-LSPLATPSPQAPNALAVHLLQAP 439
           +A P   L             P + PP  SP  +PP  SP  TPS  +P        Q+ 
Sbjct: 409 RASPTGMLSRTSITKMDSTASPTRTPPRASPTGTPPRASPTGTPSRASPTGT-----QST 463

Query: 440 FSPPPSPPVQAPFSPP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATP 497
            SP  SP   +P   P  ASP  SPS    ++ P   +   ++   S   +P  + S T 
Sbjct: 464 ASPTGSPSTASPTGSPSTASPTGSPSRASLTRTPSRASLTKMESTASITRTPSRA-SPTW 522

Query: 498 PPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPA----SFPGQAPFS-------- 545
            P    P  +P   LA   P       TP   +L   P+    + P +A  +        
Sbjct: 523 TPSTASPTGSPSTALAMGSPSRAALTRTPSRASLTRTPSRASLTTPSRASLTRTPSTVLL 582

Query: 546 ----PSASLPMSPLATPPPQAPPVL-------AAPLLQVPPSPPASPTLQAPRRPPTPGP 594
               PSAS    P  T P   P           A + + PP   ASPT   PR  PT  P
Sbjct: 583 TRMPPSASPTGMPSRTSPTGMPSSALLTKMDSTASITRTPPR--ASPTETPPRASPTGTP 640

Query: 595 DTSVSGPRLTLALAPGPPPPPSRSPSSTLS 624
               + P  T   A     PP  SP+ T S
Sbjct: 641 PR--ASPTGTPPRASPTGTPPRASPTGTPS 668



 Score =  115 bits (289), Expect = 1e-25
 Identities = 145/533 (27%), Positives = 209/533 (39%), Gaps = 82/533 (15%)

Query: 15  RTPAARAPGLLTPR--PPGSPRPPPPV----TPAALRVLGAAGAVGRKPLAERAGGIGGA 68
           RTP   +P  +  R  P G P          T +  R L  A   G  P A   G    A
Sbjct: 177 RTPPRASPTGMPSRTSPTGMPSTASLTKMDSTASITRTLSRASPTGTPPRASPTGSPPRA 236

Query: 69  TI---PESA------PRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGR 119
           ++   P +A      PRA PT   G  SR   ++  ++    R P   +T+  P  +P R
Sbjct: 237 SLSMMPSTALLIRTPPRASPT---GMLSRTSLTKMDSTASITRTPSRPSTA-SPTGTPSR 292

Query: 120 ASGTTRP---------------GPLGQKGLR-----ISAEETVARGKATEAPKRSALSAG 159
           AS +  P               G L +  L       S   T  R   T  P R+  S  
Sbjct: 293 ASLSMTPSTASLMRMLPRASPTGMLSRTSLTKMDSTASISRTPPRASITRTPSRA--SPT 350

Query: 160 ARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTE 219
            +  T+ PT GTPS A    S +  +  GL   A S    PP   P  + S+AS    T 
Sbjct: 351 GKPSTASPT-GTPSRASPTGSPSTASLTGLSSTA-SPTGTPPRASPTGTPSTAS---LTR 405

Query: 220 PSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAH-PSQPKPKGLQ 278
             P    R S  G L R +   + S+A+P  +P R+ P+      +P   PS+  P G Q
Sbjct: 406 KPP----RASPTGMLSRTSITKMDSTASPTRTPPRASPTGTPPRASPTGTPSRASPTGTQ 461

Query: 279 ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPL 338
           +            A+P   P ++SP  +PS ++   S +  +L  TP  +SLT   +T  
Sbjct: 462 ST-----------ASPTGSPSTASPTGSPSTASPTGSPSRASLTRTPSRASLTKMESTAS 510

Query: 339 PLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH------SFLPSPPLSPLATP 392
               PS ++P    +  SP  +P +    ++GSP+  A        S   +P  + L TP
Sbjct: 511 ITRTPSRASPTWTPSTASPTGSPST--ALAMGSPSRAALTRTPSRASLTRTPSRASLTTP 568

Query: 393 PPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF 452
              +        L     P ASP   P  T     P++  +  + +  S   +PP     
Sbjct: 569 SRASLTRTPSTVLLTRMPPSASPTGMPSRTSPTGMPSSALLTKMDSTASITRTPP----- 623

Query: 453 SPPASPPVSPSATPPSQAPPSLAAPPLQVPP--SPPASPP-MSPSATPPPQAP 502
              ASP  +P    P+  PP   A P   PP  SP  +PP  SP+ TP   +P
Sbjct: 624 --RASPTETPPRASPTGTPP--RASPTGTPPRASPTGTPPRASPTGTPSRASP 672



 Score =  103 bits (257), Expect = 7e-22
 Identities = 165/668 (24%), Positives = 236/668 (35%), Gaps = 123/668 (18%)

Query: 141 TVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRP 200
           T +R   T  P  ++L+    R +   TP T S  M   SRA+ T  G P          
Sbjct: 7   TPSRASPTRTPSTASLTGTPSRASLTGTPSTAS-LMGTPSRASLT--GTP---------- 53

Query: 201 PTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSAR 260
               PR S+   +  ++   SP+          L R  S SL +    ++S  R  P A 
Sbjct: 54  ----PRASLKGTTSMASLMVSPSR-------ASLTRMQSSSLLTRTPSMASLKRMPPRAS 102

Query: 261 GTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPT 320
            T   P      +P      R P        A+    P  +S   TPS +AAL   +  +
Sbjct: 103 RTRTLPRASLMRRPSTASLTRSPS------RASLTTTPSRASLSMTPSTAAALTMPSRAS 156

Query: 321 LPATPHSSSLTCQLAT-PLPLAPP-----------SPSAPPSLQTL-------------- 354
           L  TP  +SLT   +T  L   PP           SP+  PS  +L              
Sbjct: 157 LTRTPPRASLTMTPSTASLTRTPPRASPTGMPSRTSPTGMPSTASLTKMDSTASITRTLS 216

Query: 355 -PSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL----------ALP 403
             SP  TPP  + T  GSP  +A+ S +PS  L  + TPP  +P  +          +  
Sbjct: 217 RASPTGTPPRASPT--GSPP-RASLSMMPSTALL-IRTPPRASPTGMLSRTSLTKMDSTA 272

Query: 404 PLQAPPSPP--ASPPLSPLATPSPQAPNALAVHLLQAPFSP------------------- 442
            +   PS P  ASP  +P        P+  ++  +    SP                   
Sbjct: 273 SITRTPSRPSTASPTGTPSRASLSMTPSTASLMRMLPRASPTGMLSRTSLTKMDSTASIS 332

Query: 443 --PP------SPPVQAPFSPP--ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPP-M 491
             PP      +P   +P   P  ASP  +PS   P+ +P + +   L    SP  +PP  
Sbjct: 333 RTPPRASITRTPSRASPTGKPSTASPTGTPSRASPTGSPSTASLTGLSSTASPTGTPPRA 392

Query: 492 SPSATP--------PPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAP 543
           SP+ TP        PP+A P        + K    A P    P      +PP + P    
Sbjct: 393 SPTGTPSTASLTRKPPRASPTGMLSRTSITKMDSTASPTRTPPRASPTGTPPRASP---T 449

Query: 544 FSPSASLPMSPLATPPPQAPPVLAAPL-LQVPPSPPASPTLQAPRRPPTPGPDTSVSGPR 602
            +PS + P    +T  P   P  A+P       SP  SP+  +  R P+    T +    
Sbjct: 450 GTPSRASPTGTQSTASPTGSPSTASPTGSPSTASPTGSPSRASLTRTPSRASLTKME--- 506

Query: 603 LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELR-GYDSGPEGGAAASPPPDA 661
              + A     P   SP+ T S     G  S+A +     R      P   +    P  A
Sbjct: 507 ---STASITRTPSRASPTWTPSTASPTGSPSTALAMGSPSRAALTRTPSRASLTRTPSRA 563

Query: 662 ELAACHPAAWSRGPAPPLAFRGAPGA-PLPWPPATGPGSADGLCTIYETEGPESATPAPG 720
            L     A+ +R P+  L  R  P A P   P  T P        + + +   S T  P 
Sbjct: 564 SLTTPSRASLTRTPSTVLLTRMPPSASPTGMPSRTSPTGMPSSALLTKMDSTASITRTPP 623

Query: 721 ALDPGPSP 728
              P  +P
Sbjct: 624 RASPTETP 631



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 149/602 (24%), Positives = 227/602 (37%), Gaps = 85/602 (14%)

Query: 292 AAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSL 351
           A P   P  +SP  TPS ++   + +  +L  TP ++SL   + TP   +        SL
Sbjct: 2   APPTRTPSRASPTRTPSTASLTGTPSRASLTGTPSTASL---MGTPSRASLTGTPPRASL 58

Query: 352 QTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP--PLQAPP 409
           +   S  +   S +  SL    +Q++     +P ++ L   PP+A     LP   L   P
Sbjct: 59  KGTTSMASLMVSPSRASL--TRMQSSSLLTRTPSMASLKRMPPRASRTRTLPRASLMRRP 116

Query: 410 SPPA---SPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP 466
           S  +   SP  + L T   +A  ++      A   P  +   + P  P AS  ++PS   
Sbjct: 117 STASLTRSPSRASLTTTPSRASLSMTPSTAAALTMPSRASLTRTP--PRASLTMTPSTAS 174

Query: 467 PSQAPPSLAAPPLQVPPSPPASPP-------------------MSPSATPPPQAPPPLAA 507
            ++ PP  +   +    SP   P                     SP+ TPP  +  P  +
Sbjct: 175 LTRTPPRASPTGMPSRTSPTGMPSTASLTKMDSTASITRTLSRASPTGTPPRAS--PTGS 232

Query: 508 PPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL--ATPPPQAPPV 565
           PP       P     + TPP +A P+   S         +AS+  +P   +T  P   P 
Sbjct: 233 PPRASLSMMPSTALLIRTPP-RASPTGMLSRTSLTKMDSTASITRTPSRPSTASPTGTPS 291

Query: 566 LAAPLLQVPPS--------PPASPTLQAPRRPPTPGPDT---SVSGPRLTLALAP----- 609
            A+  L + PS        P ASPT    R   T    T   S + PR ++   P     
Sbjct: 292 RAS--LSMTPSTASLMRMLPRASPTGMLSRTSLTKMDSTASISRTPPRASITRTPSRASP 349

Query: 610 -------GPPPPPSR-SPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAAS--PPP 659
                   P   PSR SP+ + S   L G SS+A+ T    R   +G    A+ +  PP 
Sbjct: 350 TGKPSTASPTGTPSRASPTGSPSTASLTGLSSTASPTGTPPRASPTGTPSTASLTRKPPR 409

Query: 660 DAELAACHPAAWSRGPAPPLAFRGAPGA-PLPWPPATGPGSADGLCTIYETEGPESATPA 718
            +        + ++  +     R  P A P   PP   P       +   T+   S T +
Sbjct: 410 ASPTGMLSRTSITKMDSTASPTRTPPRASPTGTPPRASPTGTPSRASPTGTQSTASPTGS 469

Query: 719 PGALDPGPSPGTSGGKAAAGAGAGAS-SRSPKQARLGELPLGALQASVVQHLLSRTLLLA 777
           P    P  SP T+   +  G+ + AS +R+P +A L ++          +   S T   +
Sbjct: 470 PSTASPTGSPSTA---SPTGSPSRASLTRTPSRASLTKM----------ESTASITRTPS 516

Query: 778 AAEGAAGGSGGGPGGAEGGGVTGG--ARAAL----SDAELGRWAELLSPLDESRASITSV 831
            A      S   P G+    +  G  +RAAL    S A L R     S    SRAS+T  
Sbjct: 517 RASPTWTPSTASPTGSPSTALAMGSPSRAALTRTPSRASLTRTPSRASLTTPSRASLTRT 576

Query: 832 TS 833
            S
Sbjct: 577 PS 578


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score =  131 bits (329), Expect = 3e-30
 Identities = 135/461 (29%), Positives = 177/461 (38%), Gaps = 77/461 (16%)

Query: 189 LPRPAP--SARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSA 246
           LP P P   A P PP   P  S  ++S         +A       G   R  ++    SA
Sbjct: 11  LPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSA 70

Query: 247 TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPP-RKDAAPALGPLSSSPLA 305
             + S   +     G+       + P    L A   P + P  ++D A   G     P +
Sbjct: 71  PQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAG--GKTGQGPGS 128

Query: 306 -TPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQ 364
             PSP    ++ + P +P        T +       APP P+ P      P PP  PP  
Sbjct: 129 RAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPA-----PPPPTPPP-- 181

Query: 365 ATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPS 424
                            P PPL P   P P + P     PL +PP P     L  +A P 
Sbjct: 182 -----------------PPPPLPP---PLPSSSPIKT--PLVSPPGPLTKGNLPVVAPPV 219

Query: 425 PQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQA-PPSLAAPPLQVPP 483
           P AP             PPP PP      PP  PP+ P++    +A  P LA  PL +PP
Sbjct: 220 PCAP-------------PPPPPP-----PPPTPPPLPPASVLSDKAVKPQLA--PLHLPP 259

Query: 484 SPPASPPMSPSATPPPQAPPPLAAPPLQLAK----PPPQAPPALATPPLQALPSPPASFP 539
            PP  P + P   P  +A P   A P Q A+    PPP  PP  +  P  +LP+PP   P
Sbjct: 260 IPPPLPLLPPCGYPGLKAEP---ASPAQDAQEPPAPPPPLPPYASCSPRASLPAPP--LP 314

Query: 540 GQAPFSPSASLPMSPLATPPPQAPPVLA-APLLQVPPSPPASPTLQAPRRPPTPGPDTSV 598
           G    S S + P  P  +P  QAPP  A A  L  PP+PP S      +R   PG     
Sbjct: 315 GVN--SSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGK 372

Query: 599 SGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTP 639
             P         PP PP+RSP++ LS       + + T  P
Sbjct: 373 LNP---------PPAPPARSPTTELSSKSQQATAWTPTQQP 404



 Score =  105 bits (263), Expect = 1e-22
 Identities = 141/472 (29%), Positives = 172/472 (36%), Gaps = 88/472 (18%)

Query: 17  PAARAPGLLTPRPP-GSPRPPPPVTPAA---LRVLGAAGAVGRKP-LAERAGGIGGATIP 71
           P    P L  P PP G+P PPPP  P        L  A   GR   LA+   G     + 
Sbjct: 4   PPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVT 63

Query: 72  ESAPRAGP--TRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 129
           +   R+ P    S GT+     S   A+ RG   PP                G    G  
Sbjct: 64  QINDRSAPQIESSKGTNKEGGGS---ANTRGASTPP--------------TLGDLFAG-- 104

Query: 130 GQKGLRISAEETVARGKATEAPKRSALSAGARRDT-SGPTPGTPSPAMARRSRAAG-TEV 187
           G   LR + +  VA GK  + P   A S      T SGP     SP +   S A G    
Sbjct: 105 GFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAART 164

Query: 188 GLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSAT 247
             PRP   A P PPT  P              P P     PS+            S   T
Sbjct: 165 APPRPNVPA-PPPPTPPP-------------PPPPLPPPLPSS------------SPIKT 198

Query: 248 PLSSPARSGPSARG-----TPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 302
           PL SP   GP  +G      P  P  P  P P       PP  TPP    A  L   +  
Sbjct: 199 PLVSP--PGPLTKGNLPVVAPPVPCAPPPPPP-------PPPPTPPPLPPASVLSDKAVK 249

Query: 303 PLATPSPSAALQSQAPPTLPATPHSS--SLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT 360
           P   P     +    PP LP  P      L  + A+P   A   P+ PP     P PP  
Sbjct: 250 PQLAPLHLPPI----PPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPP-----PLPPYA 300

Query: 361 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALA-LPPLQAPPSPPASPPLSP 419
             S    SL +P L   +S   +PP  P  +P  QAPP  A    L APP+PP S P   
Sbjct: 301 SCS-PRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPF-- 357

Query: 420 LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP 471
           L       P A    L     +PPP+PP ++P +  +S     +A  P+Q P
Sbjct: 358 LQKKRHGRPGAGGGKL-----NPPPAPPARSPTTELSSKSQQATAWTPTQQP 404



 Score =  104 bits (259), Expect = 4e-22
 Identities = 114/401 (28%), Positives = 146/401 (36%), Gaps = 101/401 (25%)

Query: 381 LPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ--- 437
           +P PP  P   PPP  PP L  PP   P +PP S   S L    P+  +AL   + Q   
Sbjct: 1   MPVPPPPPPPLPPP--PPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTR 58

Query: 438 ----------------------------APFSPPPSPPVQAPFSPPASPPVSPSAT---- 465
                                       A      +PP          P + P+      
Sbjct: 59  LRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVA 118

Query: 466 -------PPSQAP-PSLAAPPLQVPPSPPASPPMSPSA-------TPPPQAPPPLAAPPL 510
                  P S+AP P L    +  P  PPASP +  ++       T PP+   P   PP 
Sbjct: 119 GGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPT 178

Query: 511 QLAKPPPQAPPALATPPLQA-LPSPP-----ASFPGQAPFSPSASLPMSPLATPPPQAPP 564
               PPP  PP  ++ P++  L SPP      + P  AP  P A  P  P   PPP  PP
Sbjct: 179 PPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCA--PPPPPPPPPPTPPP 236

Query: 565 VLAAPL------------LQVPPSPPASPTLQAPRRPPT--PGPDTSVSGPRLTLALAPG 610
           +  A +            L +PP PP  P L     PP   PG     + P       P 
Sbjct: 237 LPPASVLSDKAVKPQLAPLHLPPIPPPLPLL-----PPCGYPGLKAEPASPAQDAQEPPA 291

Query: 611 PPPP----PSRSPSSTLSGPDLAGHSSSATS---TPEELRGYDSGPE-GGAAASPPPDAE 662
           PPPP     S SP ++L  P L G +SS+ +    P +   + + P+  GA A P P   
Sbjct: 292 PPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAP--- 348

Query: 663 LAACHPAAWSRGPAPPLAFRGAPGA------PLPWPPATGP 697
                PA     P       G PGA      P P PPA  P
Sbjct: 349 -----PAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP 384



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 116/440 (26%), Positives = 144/440 (32%), Gaps = 135/440 (30%)

Query: 3   NKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERA 62
           +K    + G +A T  A  P  L     G     P + PA  R + A G  G+ P   RA
Sbjct: 76  SKGTNKEGGGSANTRGASTPPTLGDLFAGGF---PVLRPAGQRDV-AGGKTGQGP-GSRA 130

Query: 63  GG-------IGGATIPESAPRAGPTRSAGTSSRNPASRP--PASGRGERAPPAKNTSPG- 112
                    I G  IP ++PR G T  A  ++R    RP  PA       PP     P  
Sbjct: 131 PSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPL 190

Query: 113 PVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP 172
           P SSP +    + PGPL +  L + A                            P P  P
Sbjct: 191 PSSSPIKTPLVSPPGPLTKGNLPVVAP---------------------------PVPCAP 223

Query: 173 SPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG 232
            P               P P P+  P PP        +S       +P  A    P    
Sbjct: 224 PPPP-------------PPPPPTPPPLPP--------ASVLSDKAVKPQLAPLHLPPIPP 262

Query: 233 GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDA 292
            L             PL  P    P  +  P +PA  +Q  P       PP   PP    
Sbjct: 263 PL-------------PLLPPC-GYPGLKAEPASPAQDAQEPP------APPPPLPP---- 298

Query: 293 APALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPS--APP- 349
                       A+ SP A+L +   P LP    SS       TP PL P SPS  APP 
Sbjct: 299 -----------YASCSPRASLPA---PPLPGVNSSSE------TPPPLPPKSPSFQAPPQ 338

Query: 350 --SLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQA 407
               Q LP+PPA P SQ                       P         P      L  
Sbjct: 339 KAGAQALPAPPAPPGSQ-----------------------PFLQKKRHGRPGAGGGKLNP 375

Query: 408 PPSPPASPPLSPLATPSPQA 427
           PP+PPA  P + L++ S QA
Sbjct: 376 PPAPPARSPTTELSSKSQQA 395



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 106/416 (25%), Positives = 138/416 (33%), Gaps = 131/416 (31%)

Query: 474 LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPAL---------- 523
           +  PP   PP PP  PP+     PPP A PP++     L +  P+   AL          
Sbjct: 1   MPVPPPPPPPLPPPPPPLGAPPPPPPSA-PPVSTDTSSLRRADPKGRSALLADIQQGTRL 59

Query: 524 ---------ATPPLQA----------------LPSPP-------ASFP------------ 539
                    + P +++                  +PP         FP            
Sbjct: 60  RKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAG 119

Query: 540 ---GQAPFS--PSASLPMSPLATP--PPQAPPV-----------LAAPLLQVPPSPPASP 581
              GQ P S  PS  LP   ++ P  PP +P +            A P   VP  PP +P
Sbjct: 120 GKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP 179

Query: 582 TLQAPRRPP--------------TPGPDTS----VSGPRLTLALAPGPPPPPSR----SP 619
               P  PP               PGP T     V  P +  A  P PPPPP       P
Sbjct: 180 PPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPP 239

Query: 620 SSTLSG----PDLAGHSSSATSTPEEL------RGYDSGPEGGA------AASPPPDAEL 663
           +S LS     P LA         P  L       G  + P   A       A PPP    
Sbjct: 240 ASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPY 299

Query: 664 AACHPAAWSRGPAPPL-AFRGAPGAPLPWPPAT----GPGSADGLCTIYETEGPESATP- 717
           A+C P A    PAPPL     +   P P PP +     P    G   +     P  + P 
Sbjct: 300 ASCSPRA--SLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPF 357

Query: 718 -------APGA----LDPGPS-PGTSGGKAAAGAGAGASSRSPKQARLGELPLGAL 761
                   PGA    L+P P+ P  S     +     A++ +P Q   G+L  G+L
Sbjct: 358 LQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPGGQLRNGSL 413


>gi|239508790 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 490

 Score =  130 bits (327), Expect = 5e-30
 Identities = 141/471 (29%), Positives = 190/471 (40%), Gaps = 74/471 (15%)

Query: 265 APAHPSQPKPKGLQALRPPQVTP------PRKDAAPALGPLSSS-PLATP-----SPSAA 312
           +P  P  P    L +L  P V+P      P         P+S   PL +P     SP  +
Sbjct: 18  SPHCPLVPPHHPLVSLHHPLVSPHFPLVSPHHPLVSLHHPVSPHFPLVSPHHPLMSPHYS 77

Query: 313 LQSQAPPTLPATPHSSSLTCQLATP--LPLAPPSPSAPPSLQTLPSPPATPPSQATTSLG 370
           L S  P   P +PH     C L +P    ++P  P   P L  +PSPP+  PS       
Sbjct: 78  LVS--PQYSPVSPH-----CPLVSPHYSLVSPHRPLVSPLLSGVPSPPSDVPSLL----- 125

Query: 371 SPTLQATHSFLPSPPLSPLATPPPQAPPALALPP--LQAPPSPPASPPLSPLATPSPQAP 428
                   S +PS P S +++PP   P  L+  P  L   PSPP+  P  P   PSP + 
Sbjct: 126 --------SGVPSLP-SDVSSPPSDVPSLLSDVPSLLSGVPSPPSDVPSPPSDVPSPPSD 176

Query: 429 NALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP--PSLAAPPLQVPPSPP 486
               +  + +P S  PSPP   P  P   P +S   +PPS  P    + +PP  VP  P 
Sbjct: 177 VPSLLSGVPSPPSDVPSPPSDVPSPPSDVPLLSDVPSPPSDVPLLSDVPSPPSDVPSLPS 236

Query: 487 ASPPMSPSATPPPQAPPPLA---APPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAP 543
             P +S   +PP   P  L+   +PP  ++ PP   P  L+  P  +LPS   S     P
Sbjct: 237 DVPSLSGVPSPPSDVPSLLSGVPSPPSDIS-PPSDVPSLLSDVP--SLPSDVPSLLSGVP 293

Query: 544 FSPSASLP--MSPLATPPPQAP-PVLAAPLLQVPPSPPA---SPTLQAPRRPPTPGPDTS 597
            SP + +P  +S + +PP   P P    PLL   PSPP+   SP    P  P      + 
Sbjct: 294 -SPPSDVPSLLSDVPSPPSDVPSPPSDIPLLSGVPSPPSDVPSPPSDVPSPPSDVPLLSG 352

Query: 598 VSGPRLTLALAPGPPPPPSRSPSSTLS------------GPDLAGHSSSATSTPEELRGY 645
           V  P   + L  G P PPS  PS  +S             P      S  +  P  L G 
Sbjct: 353 VPSPLSDVPLLSGVPSPPSDVPSLLMSPHRLLMSHYSLVSPHRLDVPSLLSDVPSLLSGV 412

Query: 646 DSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLP-WPPAT 695
            S P G    S P    + +  P+  S  P+P        G P+  W P T
Sbjct: 413 PSSPSG--VPSLPSGVPILSGVPSLPSGVPSP-------SGVPITLWCPLT 454



 Score =  100 bits (248), Expect = 7e-21
 Identities = 110/366 (30%), Positives = 143/366 (39%), Gaps = 48/366 (13%)

Query: 376 ATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASP--PLSPLATP-SPQAPNALA 432
           +TH  + SP   PL   PP  P      PL +P  P  SP  PL  L  P SP  P    
Sbjct: 11  STHYSVVSPHC-PLV--PPHHPLVSLHHPLVSPHFPLVSPHHPLVSLHHPVSPHFPLVSP 67

Query: 433 VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMS 492
            H L +P     SP   +P SP   P VSP  +  S   P L +P L   PSPP+  P  
Sbjct: 68  HHPLMSPHYSLVSPQY-SPVSPHC-PLVSPHYSLVSPHRP-LVSPLLSGVPSPPSDVPSL 124

Query: 493 PSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPP--LQALPSPPASFPGQAPFSPSASL 550
            S  P         + P  ++ PP   P  L+  P  L  +PSPP+  P           
Sbjct: 125 LSGVP---------SLPSDVSSPPSDVPSLLSDVPSLLSGVPSPPSDVPS---------- 165

Query: 551 PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPG 610
           P S + +PP   P +L+   +  PPS   SP    P  P      + V  P   + L   
Sbjct: 166 PPSDVPSPPSDVPSLLSG--VPSPPSDVPSPPSDVPSPPSDVPLLSDVPSPPSDVPLLSD 223

Query: 611 PPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDA--------E 662
            P PPS  PS     P L+G  S  +  P  L G  S P      SPP D          
Sbjct: 224 VPSPPSDVPSLPSDVPSLSGVPSPPSDVPSLLSGVPSPPSD---ISPPSDVPSLLSDVPS 280

Query: 663 LAACHPAAWSRGPAPPLAFRGAPG--APLPWPPATGPGSADGLCTIYETEGPESATPAPG 720
           L +  P+  S  P+PP      P   + +P PP+  P     +  +     P S  P+P 
Sbjct: 281 LPSDVPSLLSGVPSPP---SDVPSLLSDVPSPPSDVPSPPSDIPLLSGVPSPPSDVPSPP 337

Query: 721 ALDPGP 726
           +  P P
Sbjct: 338 SDVPSP 343



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 105/366 (28%), Positives = 136/366 (37%), Gaps = 57/366 (15%)

Query: 241 SLSSSATPLSSPARSG--------PSA-RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKD 291
           SL S   PL SP  SG        PS   G P  P+  S P         P  V     D
Sbjct: 98  SLVSPHRPLVSPLLSGVPSPPSDVPSLLSGVPSLPSDVSSP---------PSDVPSLLSD 148

Query: 292 AAPALGPLSSSPLATPSPSAALQSQ------------APPTLPATPHSSSLTCQLATPLP 339
               L  + S P   PSP + + S             +PP+   +P S   +     PL 
Sbjct: 149 VPSLLSGVPSPPSDVPSPPSDVPSPPSDVPSLLSGVPSPPSDVPSPPSDVPSPPSDVPLL 208

Query: 340 LAPPSP-SAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP------LSPLATP 392
              PSP S  P L  +PSPP+  PS        P+   + S +PSPP      LS + +P
Sbjct: 209 SDVPSPPSDVPLLSDVPSPPSDVPS-------LPSDVPSLSGVPSPPSDVPSLLSGVPSP 261

Query: 393 PPQAPPALALPPLQAP-PSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAP 451
           P    P   +P L +  PS P+  P      PSP +     +  + +P S  PSPP   P
Sbjct: 262 PSDISPPSDVPSLLSDVPSLPSDVPSLLSGVPSPPSDVPSLLSDVPSPPSDVPSPPSDIP 321

Query: 452 FSPPASPPVSPSATPPSQAP-PSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPP- 509
                  P S   +PPS  P P    P L   PSP +  P+      PP   P L   P 
Sbjct: 322 LLSGVPSPPSDVPSPPSDVPSPPSDVPLLSGVPSPLSDVPLLSGVPSPPSDVPSLLMSPH 381

Query: 510 ------LQLAKPPPQAPPALATPP---LQALPSPPASFPGQAPFSPSAS-LPMSPLATPP 559
                   L  P     P+L +     L  +PS P+  P      P  S +P  P   P 
Sbjct: 382 RLLMSHYSLVSPHRLDVPSLLSDVPSLLSGVPSSPSGVPSLPSGVPILSGVPSLPSGVPS 441

Query: 560 PQAPPV 565
           P   P+
Sbjct: 442 PSGVPI 447


>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
          Length = 1682

 Score =  130 bits (326), Expect = 7e-30
 Identities = 208/756 (27%), Positives = 255/756 (33%), Gaps = 147/756 (19%)

Query: 22  PGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGI-----GGATIPESAPR 76
           PGL  P PP  P PPPP  P         G     P      G+     G A  PE    
Sbjct: 242 PGLPLPPPPLPPPPPPPPPPPP----PLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGS 297

Query: 77  AGPTRSAGTSSRN-----PASRPPASGRGERAPPAKNTSPGP----VSSPGRASGTTRPG 127
           A P R     S       PA    A   G R  PA    PGP      S G    T  PG
Sbjct: 298 APPERQEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPG 357

Query: 128 PLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT--PGTPSPAMARRSRAAGT 185
                 LR   E  V R +   +   +A +A      S P   PGT + + +  S   G 
Sbjct: 358 ----SDLR---ESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGL 410

Query: 186 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSS 245
               P P       P  +  +      S H    PS  + R+P  G           + +
Sbjct: 411 RGVEPNPGI-----PGADHYQTPALEVSHHGRLGPSAHSSRKPFLG-----------APA 454

Query: 246 ATP-LSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPL 304
           ATP LS P   GPS+   P  P     P P     L+ P     R+D    L  L     
Sbjct: 455 ATPHLSLPP--GPSSPPPPPCPRLLRPPPPPAW--LKGPACRAAREDGE-ILEELFFGTE 509

Query: 305 ATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQ 364
             P P       APP LP   H             L PP+       Q   +PP TPP+ 
Sbjct: 510 GPPRP-------APPPLP---HREGF---------LGPPASRFSVGTQDSHTPP-TPPTP 549

Query: 365 ATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALA--LPPLQAPPSP---PASPPLSP 419
            T+S  S +   +HS   S P  P++ PPP   P LA  + PL  PPSP   P  PPL P
Sbjct: 550 TTSSSNSNS--GSHS---SSPAGPVSFPPP---PYLARSIDPLPRPPSPAQNPQDPPLVP 601

Query: 420 LATPSPQAPNALAVHLLQAPFSPP--PSPPVQAPFSPPASP--PVSPSATPPSQAPPSLA 475
           L    P AP +         F  P  P P V  P +P   P  P  P +  P   PP + 
Sbjct: 602 LTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAPQPVPPGVG 661

Query: 476 APPLQVP---PSPPASPPMSPSATPPPQ---APPPLAAPPLQL----AKPPPQAPPALAT 525
             P + P     PP   P+      P +    P  LA     L     K   Q       
Sbjct: 662 ELPARGPRLFDFPPT--PLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGV 719

Query: 526 PPLQALPSPPASFPGQAPF----SPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASP 581
            P   L  P AS   Q+PF    +P+ + P   + T         A    +  P P   P
Sbjct: 720 APQPPLKEPFASL--QSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPP 777

Query: 582 TLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS-----RSPSSTLSGPDLA----GHS 632
                + PP   P              P PPPPPS     +S +S L G        G +
Sbjct: 778 PPPLAKFPPPSQPQ-------------PPPPPPPSPASLLKSLASVLEGQKYCYRGTGAA 824

Query: 633 SSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWP 692
            S    P     Y  GP  GA A PP  A              AP      A G+P P  
Sbjct: 825 VSTRPGPLPTTQYSPGPPSGATALPPTSA--------------AP-----SAQGSPQPSA 865

Query: 693 PATGPGSADGLCTIYETEGPESATPAPGALDPGPSP 728
            ++   S  G     E    E   P PG + P   P
Sbjct: 866 SSSSQFSTSGGPWARERRAGEE--PVPGPMTPTQPP 899



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 193/751 (25%), Positives = 241/751 (32%), Gaps = 151/751 (20%)

Query: 11   GAAARTP-AARAPGLLTPRPPGSP---RPPPPVTPAALRVLGAAGAVGRKP---LAERAG 63
            GA A TP  +  PG  +P PP  P   RPPPP  PA L+  G A    R+    L E   
Sbjct: 451  GAPAATPHLSLPPGPSSPPPPPCPRLLRPPPP--PAWLK--GPACRAAREDGEILEELFF 506

Query: 64   GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGT 123
            G  G   P  AP   P R        PASR     +    PP   T P P +S   ++  
Sbjct: 507  GTEGP--PRPAPPPLPHREGFLGP--PASRFSVGTQDSHTPP---TPPTPTTSSSNSNS- 558

Query: 124  TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAA 183
                                 G  + +P             +GP    P P +AR     
Sbjct: 559  ---------------------GSHSSSP-------------AGPVSFPPPPYLARSIDP- 583

Query: 184  GTEVGLPR-PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL 242
                 LPR P+P+  P+ P   P              P+P +    +  G  +RP S   
Sbjct: 584  -----LPRPPSPAQNPQDPPLVPLT--------LALPPAPPSSCHQNTSGSFRRPES--- 627

Query: 243  SSSATPLSSPARSGPSAR-GTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP--- 298
                          P  R   P+ P     P P  L   + PQ  PP     PA GP   
Sbjct: 628  --------------PRPRVSFPKTPEVGPGPPPGPLS--KAPQPVPPGVGELPARGPRLF 671

Query: 299  -LSSSPL-----------ATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPS 346
                +PL             P   A +      ++            +A   PL  P  S
Sbjct: 672  DFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFAS 731

Query: 347  APPSLQTLPSPPATPPSQA--TTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP 404
                  T  +P  T P+ A  TT+  + T  AT      P   P A PPP  PP    PP
Sbjct: 732  LQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKP---PPALPPP--PPLAKFPP 786

Query: 405  ---LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 461
                Q PP PP SP     +  S             A  S  P P     +SP   PP  
Sbjct: 787  PSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQYSP--GPPSG 844

Query: 462  PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAA-PPLQLAKPPPQAP 520
             +A PP+      AAP  Q  P P AS     S +  P A    A   P+     P Q P
Sbjct: 845  ATALPPTS-----AAPSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPP 899

Query: 521  PALATPPLQALPSPPASFPGQAP-----FSPSASLPMSPLAT------------PPPQAP 563
            P L+ PP ++                     SA+ P  P+ T            PP QA 
Sbjct: 900  PPLSLPPARSESEVLEEISRACETLVERVGRSATDPADPVDTAEPADSGTERLLPPAQAK 959

Query: 564  PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTL 623
                                Q   R        SV G R     A      P       L
Sbjct: 960  EEAGGVAAVSGSCKRRQKEHQKEHRRHRRACKDSV-GRRPREGRAKAKAKVPKEKSRRVL 1018

Query: 624  SGPDLAGHSSSATSTPEELRGYD-SGPE-GGAAASPPPDAELAACHPAAWSRGPAPPLAF 681
               DL           EE++G + S P+ GGA+ + PP A      PA  S  P PP A 
Sbjct: 1019 GNLDLQS---------EEIQGREKSRPDLGGASKAKPPTAPAPPSAPAP-SAQPTPPSAS 1068

Query: 682  RGAPGAPLPWPPATGPGSADGLCTIYETEGP 712
                 A    P   G   AD L     +EGP
Sbjct: 1069 VPGKKAREEAPGPPGVSRADMLKLRSLSEGP 1099



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 136/497 (27%), Positives = 169/497 (34%), Gaps = 98/497 (19%)

Query: 342 PPSPSA--PPSLQTLPSPPAT---PPSQATTSLGSPTLQATHSFLPS-PPLSPLATPPPQ 395
           PP   A  PP +Q  P PPA    P  +   S G    +  +S     PP  PL  PPP 
Sbjct: 195 PPVKRAAEPPVVQ--PVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPL--PPPP 250

Query: 396 APPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPP 455
            PP    PP   PP PP  PPL  LAT SP  P  L    L +        P +   +PP
Sbjct: 251 LPP----PP---PPPPPPPPPLPGLAT-SP--PFQLTKPGLWSTLHGDAWGPERKGSAPP 300

Query: 456 ASPPVSPSATP--PSQAPPSLAAPP--LQVPPSPPASPPMSPSATP----PPQAPP--PL 505
                  S     P  AP   A PP    VP +PP   P  P A      P   PP   L
Sbjct: 301 ERQEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPGSDL 360

Query: 506 AAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL--ATPPPQAP 563
               +Q ++      PA  T  +   PS P   PG    S S+S   + L    P P  P
Sbjct: 361 RESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIP 420

Query: 564 ---------------------------PVLAAPL----LQVPPSPPASPTLQAPRRPPTP 592
                                      P L AP     L +PP P + P    PR    P
Sbjct: 421 GADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPCPRLLRPP 480

Query: 593 GPDTSVSGPRLTLAL-----------------APGPPPPPSRS-----PSSTLSGPDLAG 630
            P   + GP    A                   P PPP P R      P+S  S      
Sbjct: 481 PPPAWLKGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDS 540

Query: 631 HS-----SSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAP 685
           H+     +  TS+     G  S    G  + PPP     +  P    R P+P    +  P
Sbjct: 541 HTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPL--PRPPSPAQNPQDPP 598

Query: 686 GAPL-----PWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAG 740
             PL     P PP++   +  G     E+  P  + P    + PGP PG    KA     
Sbjct: 599 LVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPL-SKAPQPVP 657

Query: 741 AGASSRSPKQARLGELP 757
            G      +  RL + P
Sbjct: 658 PGVGELPARGPRLFDFP 674



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 92/361 (25%), Positives = 131/361 (36%), Gaps = 55/361 (15%)

Query: 22   PGLLTPRPPGSPRPPPPVTPAALRVLGAAGAV--GRKPLAERAGGIGGATIPESAPRA-- 77
            P L    PP  P+PPPP  P+   +L +  +V  G+K    R  G   +T P   P    
Sbjct: 779  PPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQK-YCYRGTGAAVSTRPGPLPTTQY 837

Query: 78   GPTRSAGTSSRNPASRPPASGRGERAPPAKN-----TSPGPVSSPGRASGTTRPGPLG-- 130
             P   +G ++  P S  P S +G   P A +     TS GP +   RA     PGP+   
Sbjct: 838  SPGPPSGATALPPTSAAP-SAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPT 896

Query: 131  QKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP 190
            Q    +S     +  +  E   R+  +   R   S   P  P              V   
Sbjct: 897  QPPPPLSLPPARSESEVLEEISRACETLVERVGRSATDPADP--------------VDTA 942

Query: 191  RPAPSARPR--PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATP 248
             PA S   R  PP +   ++   A+       S + +RR        R   R+   S   
Sbjct: 943  EPADSGTERLLPPAQAKEEAGGVAAV------SGSCKRRQKEHQKEHRRHRRACKDS--- 993

Query: 249  LSSPARSGPSARGTPRAPAHPSQPKPKGLQALR----PPQVTPPRKDAAPALGPLSSS-P 303
            +    R G       RA A    PK K  + L       +    R+ + P LG  S + P
Sbjct: 994  VGRRPREG-------RAKAKAKVPKEKSRRVLGNLDLQSEEIQGREKSRPDLGGASKAKP 1046

Query: 304  LATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPS 363
               P+P +A    A PT    P S+S+  + A      PP  S    L+ L S    PP 
Sbjct: 1047 PTAPAPPSAPAPSAQPT----PPSASVPGKKAREEAPGPPGVSRADMLK-LRSLSEGPPK 1101

Query: 364  Q 364
            +
Sbjct: 1102 E 1102


>gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Homo
           sapiens]
          Length = 1487

 Score =  128 bits (322), Expect = 2e-29
 Identities = 227/880 (25%), Positives = 283/880 (32%), Gaps = 133/880 (15%)

Query: 3   NKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERA 62
           ++ DK + GA         PG  TP  PG P PP P  P  L    AA   G     E+A
Sbjct: 136 DRGDKGEKGAPGPRGRDGEPG--TPGNPGPPGPPGPPGPPGLGGNFAAQMAGG--FDEKA 191

Query: 63  GG------------IGGATIPESAPRAGPTRSAGTSSR--NPASRPPASGRGERAPPAKN 108
           GG            +G    P  A   GP    G       P    P   RG   PP K 
Sbjct: 192 GGAQLGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPPGKP 251

Query: 109 TSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARG----KATEAPKRSALSAGARRDT 164
              G    PG+A     PGP G +G   +      +G       +  K  A + G + ++
Sbjct: 252 GDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGES 311

Query: 165 SGP-TPGTPSPAMAR-----RSR-----AAGTEVGLPRPAPSARPRP--PTEGPRKSVSS 211
             P   G+P P   R     R R     AAG      +P P+  P P  P  GP      
Sbjct: 312 GSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPG---FP 368

Query: 212 ASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQ 271
            +  +  E  P   R P    G Q P      +  +P  + A   P   G P A      
Sbjct: 369 GAPGAKGEAGPTGARGPE---GAQGPRGEP-GTPGSPGPAGASGNPGTDGIPGAKGSAGA 424

Query: 272 PKPKGLQALRPPQVTPPRKDAAPALGPLSSS-------------PLATPSPSAALQSQAP 318
           P   G      P+  P  + A   LGP   +             P   P P+     Q  
Sbjct: 425 PGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAG---PQGA 481

Query: 319 PTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLP------SPPATPPSQATTSLGSP 372
           P             +     P+ PP     P  +  P       P   P  +  + L  P
Sbjct: 482 PGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGP 541

Query: 373 TLQATHSFLPSPPLSP----LATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQ-A 427
                    P  P  P    L   P  A P   + P  AP       P      P PQ A
Sbjct: 542 KGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGP------PGPQGA 595

Query: 428 PNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA 487
                V     P      P        P +P +     P        A PP    P+ PA
Sbjct: 596 RGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGL--RGLPGKDGETGAAGPP---GPAGPA 650

Query: 488 SPPMSPSATPPP--QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS 545
                  A  P   Q  P    PP +  KP  Q  P  A  P    P     FPG+   S
Sbjct: 651 GERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERG-S 709

Query: 546 PSA-------SLPMSPLATPP-----PQAPP-VLAAPLLQVPPSPPASPTLQAPR----- 587
           P A        LP +P    P     P  PP     P LQ  P    +  +  P+     
Sbjct: 710 PGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGD 769

Query: 588 ---RPP--TPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL 642
              + P   PG D    G  LT  +  GPP P   +      GP     S+ A   P E 
Sbjct: 770 VGEKGPEGAPGKD---GGRGLTGPI--GPPGPAGANGEKGEVGPPGPAGSAGARGAPGE- 823

Query: 643 RGYDSGPEGGAAASPPPDAE----LAACHPAAWSRGPAPPLAFRGAPGAPLPWPP--ATG 696
           RG ++GP G A  + PP A+           A  +G A     +G  GAP P  P   TG
Sbjct: 824 RG-ETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTG 882

Query: 697 PGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGEL 756
           P  A G       +GP  AT  PGA      PG++G     G    +    PK AR    
Sbjct: 883 PKGARG------AQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSG 936

Query: 757 PLGALQASVVQHLLSRTLLLAAAEGAAGGSG-GGPGGAEG 795
           P G      +Q         A   G  G  G  GP GAEG
Sbjct: 937 PPGRAGEPGLQG-------PAGPPGEKGEPGDDGPSGAEG 969



 Score =  119 bits (298), Expect = 1e-26
 Identities = 207/818 (25%), Positives = 246/818 (30%), Gaps = 131/818 (16%)

Query: 11   GAAART-PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG--G 67
            G   RT PA  A        PG   PP PV PA     G  GA G K  A   G  G  G
Sbjct: 330  GERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGP--GFPGAPGAKGEAGPTGARGPEG 387

Query: 68   ATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPG---PVSSPGRASGTT 124
            A  P   P    +     +S NP +      +G    P    +PG   P   PG    T 
Sbjct: 388  AQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGAT- 446

Query: 125  RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184
              GPLG KG   + E  +A  K  + PK     AG +        G P PA     R A 
Sbjct: 447  --GPLGPKGQ--TGEPGIAGFKGEQGPKGEPGPAGPQ--------GAPGPAGEEGKRGAR 494

Query: 185  TEVGLPRPA--PSARPRPPTEG-PRKSVSSASEHSTTEPSPAARRRPS-AGGGLQRPASR 240
             E G   P   P  R  P   G P +   +  + +  E  P+    P  A G   RP   
Sbjct: 495  GEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEP 554

Query: 241  SLSSSATPLSSPARSGPSAR-GTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPL 299
             L  +      P  +GP  + G   AP    +P P G Q  R            P +   
Sbjct: 555  GLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGAR----------GQPGVMGF 604

Query: 300  SSSPLATPSPSAALQSQAP--PTLPATPHSSSLTCQLATPLPLAPPSPSA------PPSL 351
                 A   P  A +   P  P L   P     T     P P  P           P   
Sbjct: 605  PGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGF 664

Query: 352  QTLPSPPATPPSQATTSLGSPTLQATHSFLPSP----PLSPLATPPPQAPPALALPPLQA 407
            Q LP PP  PP +     G P  Q       +P    P      P  +  P      LQ 
Sbjct: 665  QGLPGPPG-PPGEG----GKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQ--GLQG 717

Query: 408  PPSPPASPPLS-------PLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPV 460
            P   P +P          P   P  Q P  L            P     A  + P     
Sbjct: 718  PRGLPGTPGTDGPKGASGPAGPPGAQGPPGL---------QGMPGERGAAGIAGPKGDRG 768

Query: 461  SPSATPPSQAPPSLAAPPLQVPPSPP----ASPPMSPSATPPPQAPPPLAAPPLQLAKPP 516
                  P  AP       L  P  PP    A+        P P         P +  +  
Sbjct: 769  DVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETG 828

Query: 517  PQAPPALATPPLQALPSPPASFPGQAPFSPSASLP--MSPLATPPPQAPPVLAAPL---- 570
            P  P   A PP            G+A     A  P    P   P PQ P  +  P     
Sbjct: 829  PPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARG 888

Query: 571  LQVPPS------------PPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRS 618
             Q PP             PP S     P  PP P       G R       G   PP R+
Sbjct: 889  AQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGAR-------GDSGPPGRA 941

Query: 619  PSSTLSGP-----------DLAGHSSSATSTPEELRGYDS-----GPEG--GAAASPPPD 660
                L GP           D     +     P+ L G        G  G  G    P P 
Sbjct: 942  GEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPS 1001

Query: 661  AELA--ACHPAAWSRGPAPPLAFRGAPGAPLPW--------PPATGPGSADGLCTIYETE 710
             E        A+  RGP  P+   G PG   P         P A GP   DG   +    
Sbjct: 1002 GEPGKQGAPGASGDRGPPGPV---GPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDR 1058

Query: 711  GPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSP 748
            G   A  APGA  P  SPG +G     G    A ++ P
Sbjct: 1059 GETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGP 1096



 Score =  100 bits (250), Expect = 4e-21
 Identities = 204/860 (23%), Positives = 250/860 (29%), Gaps = 154/860 (17%)

Query: 11   GAAARTPAARAPGLLTPR-PPGSPRPPPPV----TPAALRVLGAAGAVGRKPLAERAGGI 65
            G A  T A    G   PR  PG+P  P P      P    + GA G+ G   +A   G  
Sbjct: 375  GEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFP 434

Query: 66   GGATIPESAPRAGPTRSAGTSSRNPAS--RPPASGRGERAPPAKNTSPGPVSSPGRASGT 123
            G    P      GP    G +     +  +     +GE  P     +PGP    G+    
Sbjct: 435  GPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGAR 494

Query: 124  TRPG---PLGQKGLR-------ISAEETVARGKATEAPKRSALSAGARRDTSGP-TPGTP 172
              PG   P+G  G R          ++ +A  K     +  +  AG +     P  PG P
Sbjct: 495  GEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEP 554

Query: 173  SPAMAR----RSRAAGTE--VGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR 226
                AR    R   AG +  VG P  AP    RP   GP+ +           P   A  
Sbjct: 555  GLPGARGLTGRPGDAGPQGKVG-PSGAPGEDGRPGPPGPQGARGQPGVMGFPGPK-GANG 612

Query: 227  RPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPS-------QPKPKGLQA 279
             P   G    P +  L         P + G +    P  PA P+        P P G Q 
Sbjct: 613  EPGKAGEKGLPGAPGLRGL------PGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQG 666

Query: 280  LRPPQVTP-----------PRKDAAPAL-GPLSSSPLATPSPSAALQS-QAPPTLPATPH 326
            L  P   P           P +  AP L GP           S   Q  Q P  LP TP 
Sbjct: 667  LPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPG 726

Query: 327  SSSLTCQLATPLPLAPPSPSAPPSLQTLPSP----------------------------- 357
            +           P  PP    PP LQ +P                               
Sbjct: 727  TDG---PKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDG 783

Query: 358  ------PATPPSQATTS-----LGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 406
                  P  PP  A  +     +G P    +     +P       PP   P   A PP  
Sbjct: 784  GRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPP--GPAGFAGPP-G 840

Query: 407  APPSPPASP---------------PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAP 451
            A   P A                 P  P   P PQ P  +           PP     A 
Sbjct: 841  ADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPG----AT 896

Query: 452  FSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQ 511
              P A+  V P  +  +  PP    P  +  P         P     P    P A PP +
Sbjct: 897  GFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGP-AGPPGE 955

Query: 512  LAKPPPQAPPALATPP-LQALPSPPA--SFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 568
              +P    P     PP  Q L         PGQ        LP  P   P  Q  P  + 
Sbjct: 956  KGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLP-GPSGEPGKQGAPGASG 1014

Query: 569  PLLQVPPSPPASPTLQAPRRPP----TPGPD--------TSVSGPRLTLAL-----APGP 611
               + PP P   P L  P   P    +PG D          V G R          APGP
Sbjct: 1015 D--RGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGP 1072

Query: 612  PPPPSRSPSSTLSGP--DLAGHSSSATSTPEELRGYDS--GPEGGAAASPPPDAELAACH 667
            P  P  +  +   G   +         S P   RG     GP G    +  P       H
Sbjct: 1073 PGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGH 1132

Query: 668  PAAWSR----GPAPPLAFRGA-----PGAPLPWPPATGPGSADGLCTIYETEGPESATPA 718
                      GP  P   +GA     P  P   P   GP   DG   I    GP      
Sbjct: 1133 RGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGR 1192

Query: 719  PGALDPGPSPGTSGGKAAAG 738
             G   P   PG  G     G
Sbjct: 1193 SGETGPAGPPGNPGPPGPPG 1212



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 181/715 (25%), Positives = 214/715 (29%), Gaps = 115/715 (16%)

Query: 10   AGAAARTPAARAPGLL----TPRPPGSP----RPPPPVTPAALRVLGAAGAVGRKPLAER 61
            AG A       APG       P PPG P    +P     P      GA G VG  P  ER
Sbjct: 647  AGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEA---GAPGLVG--PRGER 701

Query: 62   AGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRAS 121
             G  G    P +    GP    GT    P +  P    G   PP     PG    PG   
Sbjct: 702  -GFPGERGSPGAQGLQGPRGLPGT----PGTDGPKGASGPAGPPGAQGPPGLQGMPGERG 756

Query: 122  GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSR 181
                 GP G             RG   E     A      R  +GP  G P PA A   +
Sbjct: 757  AAGIAGPKGD------------RGDVGEKGPEGAPGKDGGRGLTGPI-GPPGPAGANGEK 803

Query: 182  AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241
                EVG P PA SA       G R +     E  T  P PA    P    G  +P ++ 
Sbjct: 804  G---EVGPPGPAGSA-------GARGAPGERGE--TGPPGPAGFAGPPGADG--QPGAKG 849

Query: 242  LSSSATP---LSSPARSGPSARGTPRAPAHPSQPK-PKGLQALRPPQVT----------P 287
                A       +P   GPS    P+ P   + PK  +G Q   PP  T          P
Sbjct: 850  EQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQG--PPGATGFPGAAGRVGP 907

Query: 288  PRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSA 347
            P  +  P   P    P     P  A     PP     P    L      P     P    
Sbjct: 908  PGSNGNPG-PPGPPGPSGKDGPKGARGDSGPPGRAGEP---GLQGPAGPPGEKGEPGDDG 963

Query: 348  PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA-----PPALAL 402
            P   +  P P      +    L     +     LP P   P     P A     PP    
Sbjct: 964  PSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVG 1023

Query: 403  PPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSP 462
            PP    P+       SP A   P    A  V   +       +  V AP +P   PP SP
Sbjct: 1024 PPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGE-----TGAVGAPGAP--GPPGSP 1076

Query: 463  SATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPA 522
                P+           Q P  P  S P        PQ P        +  +P  +    
Sbjct: 1077 GPAGPTGKQGDRGEAGAQGPMGP--SGPAGARGIQGPQGP---RGDKGEAGEPGERGLKG 1131

Query: 523  -LATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV------LAAPLLQV-- 573
                  LQ LP PP     Q    P+   P  P   P P  P        +  P+     
Sbjct: 1132 HRGFTGLQGLPGPPGPSGDQGASGPAG--PSGPRGPPGPVGPSGKDGANGIPGPIGPPGP 1189

Query: 574  --------PPSPPASPTLQAPRRPPTPGPDTSV---SGPRLTLALAPGPPPPPSRSPSST 622
                    P  PP +P    P  PP PG D S     GPR       GP P         
Sbjct: 1190 RGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPR-----EKGPDPLQYMRADQA 1244

Query: 623  LSGPDLAGHSSSATSTPEELRGYDS---GPEGGAAASPPPDAELAACHPAAWSRG 674
              G  L  H +   +T + L         PEG          +L  CHP  W  G
Sbjct: 1245 AGG--LRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHP-EWKSG 1296


>gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 1418

 Score =  128 bits (322), Expect = 2e-29
 Identities = 227/880 (25%), Positives = 283/880 (32%), Gaps = 133/880 (15%)

Query: 3   NKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERA 62
           ++ DK + GA         PG  TP  PG P PP P  P  L    AA   G     E+A
Sbjct: 67  DRGDKGEKGAPGPRGRDGEPG--TPGNPGPPGPPGPPGPPGLGGNFAAQMAGG--FDEKA 122

Query: 63  GG------------IGGATIPESAPRAGPTRSAGTSSR--NPASRPPASGRGERAPPAKN 108
           GG            +G    P  A   GP    G       P    P   RG   PP K 
Sbjct: 123 GGAQLGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPPGKP 182

Query: 109 TSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARG----KATEAPKRSALSAGARRDT 164
              G    PG+A     PGP G +G   +      +G       +  K  A + G + ++
Sbjct: 183 GDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGES 242

Query: 165 SGP-TPGTPSPAMAR-----RSR-----AAGTEVGLPRPAPSARPRP--PTEGPRKSVSS 211
             P   G+P P   R     R R     AAG      +P P+  P P  P  GP      
Sbjct: 243 GSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPG---FP 299

Query: 212 ASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQ 271
            +  +  E  P   R P    G Q P      +  +P  + A   P   G P A      
Sbjct: 300 GAPGAKGEAGPTGARGPE---GAQGPRGEP-GTPGSPGPAGASGNPGTDGIPGAKGSAGA 355

Query: 272 PKPKGLQALRPPQVTPPRKDAAPALGPLSSS-------------PLATPSPSAALQSQAP 318
           P   G      P+  P  + A   LGP   +             P   P P+     Q  
Sbjct: 356 PGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAG---PQGA 412

Query: 319 PTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLP------SPPATPPSQATTSLGSP 372
           P             +     P+ PP     P  +  P       P   P  +  + L  P
Sbjct: 413 PGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGP 472

Query: 373 TLQATHSFLPSPPLSP----LATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQ-A 427
                    P  P  P    L   P  A P   + P  AP       P      P PQ A
Sbjct: 473 KGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGP------PGPQGA 526

Query: 428 PNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA 487
                V     P      P        P +P +     P        A PP    P+ PA
Sbjct: 527 RGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGL--RGLPGKDGETGAAGPP---GPAGPA 581

Query: 488 SPPMSPSATPPP--QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS 545
                  A  P   Q  P    PP +  KP  Q  P  A  P    P     FPG+   S
Sbjct: 582 GERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERG-S 640

Query: 546 PSA-------SLPMSPLATPP-----PQAPP-VLAAPLLQVPPSPPASPTLQAPR----- 587
           P A        LP +P    P     P  PP     P LQ  P    +  +  P+     
Sbjct: 641 PGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGD 700

Query: 588 ---RPP--TPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL 642
              + P   PG D    G  LT  +  GPP P   +      GP     S+ A   P E 
Sbjct: 701 VGEKGPEGAPGKD---GGRGLTGPI--GPPGPAGANGEKGEVGPPGPAGSAGARGAPGE- 754

Query: 643 RGYDSGPEGGAAASPPPDAE----LAACHPAAWSRGPAPPLAFRGAPGAPLPWPP--ATG 696
           RG ++GP G A  + PP A+           A  +G A     +G  GAP P  P   TG
Sbjct: 755 RG-ETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTG 813

Query: 697 PGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGEL 756
           P  A G       +GP  AT  PGA      PG++G     G    +    PK AR    
Sbjct: 814 PKGARG------AQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSG 867

Query: 757 PLGALQASVVQHLLSRTLLLAAAEGAAGGSG-GGPGGAEG 795
           P G      +Q         A   G  G  G  GP GAEG
Sbjct: 868 PPGRAGEPGLQG-------PAGPPGEKGEPGDDGPSGAEG 900



 Score =  119 bits (298), Expect = 1e-26
 Identities = 207/818 (25%), Positives = 246/818 (30%), Gaps = 131/818 (16%)

Query: 11   GAAART-PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG--G 67
            G   RT PA  A        PG   PP PV PA     G  GA G K  A   G  G  G
Sbjct: 261  GERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGP--GFPGAPGAKGEAGPTGARGPEG 318

Query: 68   ATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPG---PVSSPGRASGTT 124
            A  P   P    +     +S NP +      +G    P    +PG   P   PG    T 
Sbjct: 319  AQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGAT- 377

Query: 125  RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184
              GPLG KG   + E  +A  K  + PK     AG +        G P PA     R A 
Sbjct: 378  --GPLGPKGQ--TGEPGIAGFKGEQGPKGEPGPAGPQ--------GAPGPAGEEGKRGAR 425

Query: 185  TEVGLPRPA--PSARPRPPTEG-PRKSVSSASEHSTTEPSPAARRRPS-AGGGLQRPASR 240
             E G   P   P  R  P   G P +   +  + +  E  P+    P  A G   RP   
Sbjct: 426  GEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEP 485

Query: 241  SLSSSATPLSSPARSGPSAR-GTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPL 299
             L  +      P  +GP  + G   AP    +P P G Q  R            P +   
Sbjct: 486  GLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGAR----------GQPGVMGF 535

Query: 300  SSSPLATPSPSAALQSQAP--PTLPATPHSSSLTCQLATPLPLAPPSPSA------PPSL 351
                 A   P  A +   P  P L   P     T     P P  P           P   
Sbjct: 536  PGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGF 595

Query: 352  QTLPSPPATPPSQATTSLGSPTLQATHSFLPSP----PLSPLATPPPQAPPALALPPLQA 407
            Q LP PP  PP +     G P  Q       +P    P      P  +  P      LQ 
Sbjct: 596  QGLPGPPG-PPGEG----GKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQ--GLQG 648

Query: 408  PPSPPASPPLS-------PLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPV 460
            P   P +P          P   P  Q P  L            P     A  + P     
Sbjct: 649  PRGLPGTPGTDGPKGASGPAGPPGAQGPPGL---------QGMPGERGAAGIAGPKGDRG 699

Query: 461  SPSATPPSQAPPSLAAPPLQVPPSPP----ASPPMSPSATPPPQAPPPLAAPPLQLAKPP 516
                  P  AP       L  P  PP    A+        P P         P +  +  
Sbjct: 700  DVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETG 759

Query: 517  PQAPPALATPPLQALPSPPASFPGQAPFSPSASLP--MSPLATPPPQAPPVLAAPL---- 570
            P  P   A PP            G+A     A  P    P   P PQ P  +  P     
Sbjct: 760  PPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARG 819

Query: 571  LQVPPS------------PPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRS 618
             Q PP             PP S     P  PP P       G R       G   PP R+
Sbjct: 820  AQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGAR-------GDSGPPGRA 872

Query: 619  PSSTLSGP-----------DLAGHSSSATSTPEELRGYDS-----GPEG--GAAASPPPD 660
                L GP           D     +     P+ L G        G  G  G    P P 
Sbjct: 873  GEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPS 932

Query: 661  AELA--ACHPAAWSRGPAPPLAFRGAPGAPLPW--------PPATGPGSADGLCTIYETE 710
             E        A+  RGP  P+   G PG   P         P A GP   DG   +    
Sbjct: 933  GEPGKQGAPGASGDRGPPGPV---GPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDR 989

Query: 711  GPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSP 748
            G   A  APGA  P  SPG +G     G    A ++ P
Sbjct: 990  GETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGP 1027



 Score =  100 bits (250), Expect = 4e-21
 Identities = 204/860 (23%), Positives = 250/860 (29%), Gaps = 154/860 (17%)

Query: 11   GAAARTPAARAPGLLTPR-PPGSPRPPPPV----TPAALRVLGAAGAVGRKPLAERAGGI 65
            G A  T A    G   PR  PG+P  P P      P    + GA G+ G   +A   G  
Sbjct: 306  GEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFP 365

Query: 66   GGATIPESAPRAGPTRSAGTSSRNPAS--RPPASGRGERAPPAKNTSPGPVSSPGRASGT 123
            G    P      GP    G +     +  +     +GE  P     +PGP    G+    
Sbjct: 366  GPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGAR 425

Query: 124  TRPG---PLGQKGLR-------ISAEETVARGKATEAPKRSALSAGARRDTSGP-TPGTP 172
              PG   P+G  G R          ++ +A  K     +  +  AG +     P  PG P
Sbjct: 426  GEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEP 485

Query: 173  SPAMAR----RSRAAGTE--VGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR 226
                AR    R   AG +  VG P  AP    RP   GP+ +           P   A  
Sbjct: 486  GLPGARGLTGRPGDAGPQGKVG-PSGAPGEDGRPGPPGPQGARGQPGVMGFPGPK-GANG 543

Query: 227  RPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPS-------QPKPKGLQA 279
             P   G    P +  L         P + G +    P  PA P+        P P G Q 
Sbjct: 544  EPGKAGEKGLPGAPGLRGL------PGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQG 597

Query: 280  LRPPQVTP-----------PRKDAAPAL-GPLSSSPLATPSPSAALQS-QAPPTLPATPH 326
            L  P   P           P +  AP L GP           S   Q  Q P  LP TP 
Sbjct: 598  LPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPG 657

Query: 327  SSSLTCQLATPLPLAPPSPSAPPSLQTLPSP----------------------------- 357
            +           P  PP    PP LQ +P                               
Sbjct: 658  TDG---PKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDG 714

Query: 358  ------PATPPSQATTS-----LGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 406
                  P  PP  A  +     +G P    +     +P       PP   P   A PP  
Sbjct: 715  GRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPP--GPAGFAGPP-G 771

Query: 407  APPSPPASP---------------PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAP 451
            A   P A                 P  P   P PQ P  +           PP     A 
Sbjct: 772  ADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPG----AT 827

Query: 452  FSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQ 511
              P A+  V P  +  +  PP    P  +  P         P     P    P A PP +
Sbjct: 828  GFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGP-AGPPGE 886

Query: 512  LAKPPPQAPPALATPP-LQALPSPPA--SFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 568
              +P    P     PP  Q L         PGQ        LP  P   P  Q  P  + 
Sbjct: 887  KGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLP-GPSGEPGKQGAPGASG 945

Query: 569  PLLQVPPSPPASPTLQAPRRPP----TPGPD--------TSVSGPRLTLAL-----APGP 611
               + PP P   P L  P   P    +PG D          V G R          APGP
Sbjct: 946  D--RGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGP 1003

Query: 612  PPPPSRSPSSTLSGP--DLAGHSSSATSTPEELRGYDS--GPEGGAAASPPPDAELAACH 667
            P  P  +  +   G   +         S P   RG     GP G    +  P       H
Sbjct: 1004 PGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGH 1063

Query: 668  PAAWSR----GPAPPLAFRGA-----PGAPLPWPPATGPGSADGLCTIYETEGPESATPA 718
                      GP  P   +GA     P  P   P   GP   DG   I    GP      
Sbjct: 1064 RGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGR 1123

Query: 719  PGALDPGPSPGTSGGKAAAG 738
             G   P   PG  G     G
Sbjct: 1124 SGETGPAGPPGNPGPPGPPG 1143



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 181/715 (25%), Positives = 214/715 (29%), Gaps = 115/715 (16%)

Query: 10   AGAAARTPAARAPGLL----TPRPPGSP----RPPPPVTPAALRVLGAAGAVGRKPLAER 61
            AG A       APG       P PPG P    +P     P      GA G VG  P  ER
Sbjct: 578  AGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEA---GAPGLVG--PRGER 632

Query: 62   AGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRAS 121
             G  G    P +    GP    GT    P +  P    G   PP     PG    PG   
Sbjct: 633  -GFPGERGSPGAQGLQGPRGLPGT----PGTDGPKGASGPAGPPGAQGPPGLQGMPGERG 687

Query: 122  GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSR 181
                 GP G             RG   E     A      R  +GP  G P PA A   +
Sbjct: 688  AAGIAGPKGD------------RGDVGEKGPEGAPGKDGGRGLTGPI-GPPGPAGANGEK 734

Query: 182  AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241
                EVG P PA SA       G R +     E  T  P PA    P    G  +P ++ 
Sbjct: 735  G---EVGPPGPAGSA-------GARGAPGERGE--TGPPGPAGFAGPPGADG--QPGAKG 780

Query: 242  LSSSATP---LSSPARSGPSARGTPRAPAHPSQPK-PKGLQALRPPQVT----------P 287
                A       +P   GPS    P+ P   + PK  +G Q   PP  T          P
Sbjct: 781  EQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQG--PPGATGFPGAAGRVGP 838

Query: 288  PRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSA 347
            P  +  P   P    P     P  A     PP     P    L      P     P    
Sbjct: 839  PGSNGNPG-PPGPPGPSGKDGPKGARGDSGPPGRAGEP---GLQGPAGPPGEKGEPGDDG 894

Query: 348  PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA-----PPALAL 402
            P   +  P P      +    L     +     LP P   P     P A     PP    
Sbjct: 895  PSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVG 954

Query: 403  PPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSP 462
            PP    P+       SP A   P    A  V   +       +  V AP +P   PP SP
Sbjct: 955  PPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGE-----TGAVGAPGAP--GPPGSP 1007

Query: 463  SATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPA 522
                P+           Q P  P  S P        PQ P        +  +P  +    
Sbjct: 1008 GPAGPTGKQGDRGEAGAQGPMGP--SGPAGARGIQGPQGP---RGDKGEAGEPGERGLKG 1062

Query: 523  -LATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV------LAAPLLQV-- 573
                  LQ LP PP     Q    P+   P  P   P P  P        +  P+     
Sbjct: 1063 HRGFTGLQGLPGPPGPSGDQGASGPAG--PSGPRGPPGPVGPSGKDGANGIPGPIGPPGP 1120

Query: 574  --------PPSPPASPTLQAPRRPPTPGPDTSV---SGPRLTLALAPGPPPPPSRSPSST 622
                    P  PP +P    P  PP PG D S     GPR       GP P         
Sbjct: 1121 RGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPR-----EKGPDPLQYMRADQA 1175

Query: 623  LSGPDLAGHSSSATSTPEELRGYDS---GPEGGAAASPPPDAELAACHPAAWSRG 674
              G  L  H +   +T + L         PEG          +L  CHP  W  G
Sbjct: 1176 AGG--LRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHP-EWKSG 1227


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score =  126 bits (317), Expect = 7e-29
 Identities = 159/565 (28%), Positives = 197/565 (34%), Gaps = 89/565 (15%)

Query: 250  SSPARSG-----PSARGTPRAPAHP----SQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300
            +SP   G     P   G P  P  P    S P+ K    +    +  PR+ +        
Sbjct: 746  TSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEIS--LIVSPRRISVQLDSHQP 803

Query: 301  SSPLATPSPSAALQSQAPPTLPAT--PHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPP 358
            +  ++ P P  +L   A    P +  PHS S   Q +    ++    SA  +   +PSPP
Sbjct: 804  TQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVS----SAFKNSCNIPSPP 859

Query: 359  ATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQA-----PPSPP- 412
              P +++++S+  P L       P PPL  +  P   +      PPLQ      PP PP 
Sbjct: 860  PLPCTESSSSM--PGLGMVPP--PPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPL 915

Query: 413  ---ASPPLSPL----ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT 465
                 PP  PL      P P  P A        P +  P PP       P  PP+  +  
Sbjct: 916  PGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGI 975

Query: 466  PPSQAPPSLAAPP------LQVPPSPP------ASPPMSPSATPPPQAPPPLAA------ 507
            PP    P    PP        +PP PP        PP  P A  PP  PPPL        
Sbjct: 976  PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP--PPPLPGAGIPPP 1033

Query: 508  PPLQLAK-PPPQAPPALATPPLQALPS----PPASFPGQAPFSPSASLPMSPLATPPP-- 560
            PPL  A  PPP   P    PP   LP     PP   PG A   P   LP + +  PPP  
Sbjct: 1034 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AGIPPPPPLPGAGIPPPPPLP 1092

Query: 561  --QAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPP------ 612
                PP    P + +PP PP  P    P  PP PG       P     + P PP      
Sbjct: 1093 GAGIPPPPPLPGVGIPPPPPL-PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGI 1151

Query: 613  PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWS 672
            PPP   P + +  P     +      P    G    P       PPP     A  P    
Sbjct: 1152 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIP---- 1207

Query: 673  RGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGP-------ESATPAPGALDPG 725
              P PPL   G P  P P PP   PG+      +    GP        S  P P      
Sbjct: 1208 --PPPPLPGMGIP--PAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFL 1263

Query: 726  PSPGTSGGKAAAGAGAGASSRSPKQ 750
            P P  SG     G G      S KQ
Sbjct: 1264 PPPLPSG---LFGLGMNQDKGSRKQ 1285



 Score =  119 bits (298), Expect = 1e-26
 Identities = 131/440 (29%), Positives = 154/440 (35%), Gaps = 76/440 (17%)

Query: 169  PGTPSPAMARRSRAAGTEV--GLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR 226
            P  PS A+ +     GTE+    P P P A   PP   P   +          P P    
Sbjct: 889  PTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGIL---------PLP---- 935

Query: 227  RPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVT 286
             P  G G+  P     ++   P   P    P     P A   P  P P     + PP   
Sbjct: 936  -PLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGA--GIPPP--- 989

Query: 287  PPRKDAA-PALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSP 345
            PP   A  P   PL  + +  P P        PP LP               +P  PP P
Sbjct: 990  PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG------------IPPPPPLP 1037

Query: 346  SA----PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALA 401
             A    PP L     PP  PP      +  P         P PPL     PPP   P   
Sbjct: 1038 GAGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1095

Query: 402  LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 461
            +PP   PP P    P      P P  P A            PP PP+     PP  PP+ 
Sbjct: 1096 IPP--PPPLPGVGIP------PPPPLPGA----------GIPPPPPLPGAGIPP-PPPLP 1136

Query: 462  PSATPPSQAPPSLAAPPLQVPPSPPAS---PPMSPSATPPPQAPPPLAAPPLQLAKPPPQ 518
             +  PP    P +  PP   PP P A    PP  P A  PP  PPPL      +  PPP 
Sbjct: 1137 GAGIPPPPPLPRVGIPP--PPPLPGAGIPPPPPLPGAGIPP--PPPLPG----VGIPPPP 1188

Query: 519  APPALATPPLQALPS----PPASFPGQA-PFSPSASLPMSPLATPPPQAPPVLAAPLL-Q 572
              P +  PP   LP     PP   PG   P +P+  LP      PPP   PV   PLL Q
Sbjct: 1189 PLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQ 1248

Query: 573  VPPSPPASPTLQAPRRPPTP 592
            V  S   +P +     PP P
Sbjct: 1249 VGSSTLPTPQVCGFLPPPLP 1268



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 104/375 (27%), Positives = 127/375 (33%), Gaps = 53/375 (14%)

Query: 389  LATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAP----FSPPP 444
            + T P +    L LPP+      P  PP  P A   PQ      + L+ +P         
Sbjct: 744  IQTSPTEEGGVLTLPPVDG---LPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDS 800

Query: 445  SPPVQAPFSPPASPPV--SPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP 502
              P Q+   PP  P +  S     P   PP   +   Q       S     S   P  +P
Sbjct: 801  HQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIP--SP 858

Query: 503  PPL-------AAPPLQLAKPPPQAPPALATP--PLQALPSPP-----ASFPGQAPFSPSA 548
            PPL       + P L +  PPP   P +  P  P  A+P PP        P   P  P A
Sbjct: 859  PPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGA 918

Query: 549  SLPMSPLATPPPQAPPVLAAPLLQVP----PSPPASPTLQAPRRPPTPGPDTSVSGPRLT 604
             +P      PPP  P     PL  +P    P PP  P    P  PP PG    +  P   
Sbjct: 919  GIP------PPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPG 972

Query: 605  LALAPGPP------PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP 658
              + P PP      PPP   P + +  P     +      P    G    P    A  PP
Sbjct: 973  AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1032

Query: 659  PDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPA 718
            P     A  P      P PPL     PGA +P PP   PG+           G     P 
Sbjct: 1033 PPPLPGAGIP------PPPPL-----PGAGIP-PPPPLPGAGIPPPPPLPGAGIPPPPPL 1080

Query: 719  PGALDPGPSPGTSGG 733
            PGA  P P P    G
Sbjct: 1081 PGAGIPPPPPLPGAG 1095



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 122/454 (26%), Positives = 146/454 (32%), Gaps = 99/454 (21%)

Query: 12   AAARTPAARAPGLLTPRPP---GSPRPPPPVTPAA----LRVLGAAGAVGRKPLAERAGG 64
            A  + P  +   +L P PP   G+  PPPP  P A    L  L  AG     PL      
Sbjct: 895  AIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLP----- 949

Query: 65   IGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTT 124
              GA IP   P  G    AG         PP  G G   PP    +  P   P   +G  
Sbjct: 950  --GAAIPPPPPLPG----AGI-----PLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 998

Query: 125  RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184
             P PL   G+                P      AG       P  G P P         G
Sbjct: 999  PPPPLPGAGI---------------PPPPPLPGAGIPPPPPLPGAGIPPP-----PPLPG 1038

Query: 185  TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSS 244
              +  P P P A   PP   P   +          P P     P  G G+  P     + 
Sbjct: 1039 AGIPPPPPLPGAGIPPPPPLPGAGI---------PPPP-----PLPGAGIPPPPPLPGAG 1084

Query: 245  SATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAA-PALGPLSSSP 303
               P   P    P     P     P  P P     + PP   PP   A  P   PL  + 
Sbjct: 1085 IPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGA--GIPPP---PPLPGAGIPPPPPLPGAG 1139

Query: 304  LATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSA----PPSLQTLPSPPA 359
            +  P P   +    PP LP               +P  PP P A    PP L  +  PP 
Sbjct: 1140 IPPPPPLPRVGIPPPPPLP------------GAGIPPPPPLPGAGIPPPPPLPGVGIPPP 1187

Query: 360  TPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPAS----- 414
             P       +G P         P PPL     PPP   P + +PP  APP PP       
Sbjct: 1188 PP----LPGVGIP---------PPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPP 1234

Query: 415  PPLSPLATPS--PQAPNALAVHLLQAPFSPPPSP 446
            PPL P++ P   PQ  ++         F PPP P
Sbjct: 1235 PPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLP 1268



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 85/323 (26%), Positives = 110/323 (34%), Gaps = 44/323 (13%)

Query: 412 PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP 471
           PA+PP +   +P P A   L   LL          P       P SP    + +  S  P
Sbjct: 232 PAAPPTA--VSPQPGAFLGLDRFLLG---------PSGGAGEAPGSPDTEQALSALSDLP 280

Query: 472 PSLAAPPL--QVPPSPPASP----PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALA- 524
            SLAA P   Q PPSP   P    P  P+A P  +  P   A P   A P  +A  A   
Sbjct: 281 ESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVR 340

Query: 525 -------TPPLQALPSPPASFPGQ--APFSPSASLPMSPLATPPPQAPPVLAAPLLQVPP 575
                       A    P   PG+  AP       P      P  +A    A     +P 
Sbjct: 341 GAGDTDEEGEEDAFEDAPRGSPGEEWAP-EVGEDAPQRLGEEPEEEAQGPDAPAAASLPG 399

Query: 576 SPPASPTLQAPRRPPTP----GPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGH 631
           SP  S     P    TP         +S P  + + +P   P   R P  +LS       
Sbjct: 400 SPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPSQSPNQSPRIKRRPEPSLSRGSRTAL 459

Query: 632 SSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPG----- 686
           +S A   P +    D G   G + S     EL A  P     G +  L  RG        
Sbjct: 460 ASVA--APAKKHRADGGLAAGLSRSADWTEELGARTPRV---GGSAHLLERGVASDSGGG 514

Query: 687 -APLPWPPATG-PGSADGLCTIY 707
            +P     A+G P +ADG   ++
Sbjct: 515 VSPALAAKASGAPAAADGFQNVF 537



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 50/215 (23%), Positives = 83/215 (38%), Gaps = 16/215 (7%)

Query: 165 SGPTPGTPSP-----AMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTE 219
           +G  PG+P       A++    +   E   P+  PS    P +E P  S+ +A   +   
Sbjct: 260 AGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAP--SLPAAQPAAKDS 317

Query: 220 PSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA-RGTPRAPAHPSQPKPKGLQ 278
           PS  A   P AG G +   +    +  T       +   A RG+P     P   +    +
Sbjct: 318 PSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQR 377

Query: 279 ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPL 338
               P+      DA     P ++S   +P+PS       P   P   +  + T QL++P 
Sbjct: 378 LGEEPEEEAQGPDA-----PAAASLPGSPAPSQRCFKPYPLITPC--YIKTTTRQLSSPN 430

Query: 339 PLAPPSPSAPPSLQTLPSPPATPPSQ-ATTSLGSP 372
                SP+  P ++  P P  +  S+ A  S+ +P
Sbjct: 431 HSPSQSPNQSPRIKRRPEPSLSRGSRTALASVAAP 465



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 111/467 (23%), Positives = 149/467 (31%), Gaps = 60/467 (12%)

Query: 48  GAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAK 107
           GA  A+G + +     G GG        + G     G  S    S+  +     RA    
Sbjct: 22  GAEDALGPRDVEATKKGSGGKKALGKHGKGGGGGGGGGESGKKKSKSDS-----RASVFS 76

Query: 108 NTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAP--KRSALSAG-ARRDT 164
           N       S G+ +G +R   L  + L+ + E   A    T+ P    SA  AG +  + 
Sbjct: 77  NLRIRKNLSKGKGAGGSREDVLDSQALQ-TGELDSAHSLLTKTPDLSLSADEAGLSDTEC 135

Query: 165 SGPT----PGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE----HS 216
           + P     PG P PA AR         G P            +G R S  S ++    HS
Sbjct: 136 ADPFEVTGPGGPGPAEARVG-------GRPIAEDVETAAGAQDGQRTSSGSDTDIYSFHS 188

Query: 217 TTEPSP-------AARRRPSAGGGLQ-----RPASRSLSSSATPLSSPARSGPSAR---G 261
            TE          A R +      LQ     +   + L  +  P + P    P      G
Sbjct: 189 ATEQEDLLSDIQQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLG 248

Query: 262 TPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTL 321
             R    PS    +   +    Q      D   +L      P   PSP     S+AP   
Sbjct: 249 LDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLP 308

Query: 322 PATPHSSSLTCQLATPLPLAPP---SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH 378
            A P +       A P P A P   +  AP              +      GSP  +   
Sbjct: 309 AAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAP 368

Query: 379 SFLPSPPLSPLATPP------PQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALA 432
                 P   L   P      P AP A +LP   AP      P   PL TP         
Sbjct: 369 EVGEDAP-QRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKP--YPLITP-------CY 418

Query: 433 VHLLQAPFSPPPSPPVQAP-FSPPASPPVSPSATPPSQ-APPSLAAP 477
           +       S P   P Q+P  SP       PS +  S+ A  S+AAP
Sbjct: 419 IKTTTRQLSSPNHSPSQSPNQSPRIKRRPEPSLSRGSRTALASVAAP 465



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 54/205 (26%), Positives = 63/205 (30%), Gaps = 34/205 (16%)

Query: 571 LQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAG 630
           LQ    P A PT  +P+     G D  + GP      APG               PD   
Sbjct: 226 LQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPG--------------SPDTEQ 271

Query: 631 HSSSATSTPEELRGYDSGPE-----GGAAASPPPDAELAACHPAAWSRGPAPPLAF-RGA 684
             S+ +  PE L      P+     GG   S  P   L A  PAA     +    F    
Sbjct: 272 ALSALSDLPESLAAEPREPQQPPSPGGLPVSEAP--SLPAAQPAAKDSPSSTAFPFPEAG 329

Query: 685 PGAPLPWPPATGPGSAD--GLCTIYETE---------GPESATPAPGALDPGPSPGTSGG 733
           PG      P  G G  D  G    +E            PE    AP  L   P     G 
Sbjct: 330 PGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGP 389

Query: 734 KAAAGAGAGASSRSPKQARLGELPL 758
            A A A     S +P Q      PL
Sbjct: 390 DAPAAASL-PGSPAPSQRCFKPYPL 413


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score =  124 bits (312), Expect = 3e-28
 Identities = 173/626 (27%), Positives = 225/626 (35%), Gaps = 98/626 (15%)

Query: 31  GSPRPPPPVTPAALRV-LGAAGAVGRKPLA---ERAGGIGGATIPESAPRAGPTRSAGTS 86
           G+  P     PA +   L       R+ +A    RA G+   ++P   P A  + S    
Sbjct: 28  GAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP---PAAAESPSMHRK 84

Query: 87  SRNPASRPPA-SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL--GQKGLRISAEETVA 143
               +S PP  SGR    PP       P  S  R + T R      G+    IS +E+ +
Sbjct: 85  QELDSSHPPKQSGR----PPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKS 140

Query: 144 RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 203
           R    E  K S +            PG  S   A    A  + V    P           
Sbjct: 141 RTDLKEEHKSSMM------------PGFLSEVNALS--AVSSVVNKFNPFDLI------- 179

Query: 204 GPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTP 263
               S S AS+  TT+     ++      G+ +P  +           P +  P  +G  
Sbjct: 180 ----SDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQ---------QPPKPIPKQQGPG 226

Query: 264 RAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPS-AALQSQAPPTLP 322
           R P       PK + + +P ++    K   P  G     P  TP    A L  Q   + P
Sbjct: 227 RDPLQ-QDGTPKSISSQQPEKI----KSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRP 281

Query: 323 ATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPS-PPATPPSQATTSLGSPTLQATHSFL 381
            T  +  +  +   P   + PSPS PP  Q  P  PPA  P    +  G     A  S L
Sbjct: 282 QTKQADIVRGESVKP---SLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGL 338

Query: 382 PSP-PLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQA----PNALA---- 432
             P    P    PP  PP    PP Q  P  PA PP     +  P +    P ALA    
Sbjct: 339 TKPLAQQPGTVKPPVQPPGTTKPPAQ--PLGPAKPPAQQTGSEKPSSEQPGPKALAQPPG 396

Query: 433 VHLLQAPFSPPPSPPVQAPFSP-----------PASPPVSPSATPPSQAPPSLAAPPLQV 481
           V    A    P  PP Q   +P           PA  P  P+ TP  Q  P    P  Q 
Sbjct: 397 VGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAP-GPTKTPVQQPGPG-KIPAQQA 454

Query: 482 PPSPPASPPMSPSATPPPQAPPPLAAPPLQL--AKPPPQAPPALATPPLQALPS--PPAS 537
            P   ++    P+  PP Q P P   PP Q   AKPPPQ P + A PP Q   S  PP  
Sbjct: 455 GPGKTSAQQTGPTK-PPSQLPGPAKPPPQQPGPAKPPPQQPGS-AKPPSQQPGSTKPPPQ 512

Query: 538 FPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTS 597
            PG  P  PS   P  P +T PP   P  A P  Q P   PA P+ Q   +P +    T 
Sbjct: 513 QPG--PAKPS---PQQPGSTKPPSQQPGSAKPSAQQPS--PAKPSAQQSTKPVS---QTG 562

Query: 598 VSGPRLTLALAPGPPPPPSRSPSSTL 623
              P     ++P    PPS+    T+
Sbjct: 563 SGKPLQPPTVSPSAKQPPSQGLPKTI 588



 Score =  117 bits (294), Expect = 3e-26
 Identities = 175/728 (24%), Positives = 262/728 (35%), Gaps = 107/728 (14%)

Query: 5   RDKAKAGAAARTPAARAPGLLTPRPPGSPRP--PPPVTPAALRVLGAAGAVGRKPLAERA 62
           RD  +     ++ +++ P  +  +PPG+ +P   P  TP              +P  ++A
Sbjct: 227 RDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQA 286

Query: 63  GGIGGATIPESAPRAG-PTRSAGTSSRNPASRP--PASGRGERAPPAKNTS--------P 111
             + G ++  S P    P     T  + PA +P    S  G   PPA+ +         P
Sbjct: 287 DIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQP 346

Query: 112 GPVSSPGRASGTTRPG--PLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTP 169
           G V  P +  GTT+P   PLG    +  A++T +   ++E P   AL   A+    G TP
Sbjct: 347 GTVKPPVQPPGTTKPPAQPLGPA--KPPAQQTGSEKPSSEQPGPKAL---AQPPGVGKTP 401

Query: 170 GT-PSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRP 228
              P PA     +    +VG P+P      +P  + P K+    ++    +P P      
Sbjct: 402 AQQPGPA-----KPPTQQVGTPKPLAQ---QPGLQSPAKA-PGPTKTPVQQPGPGKIPAQ 452

Query: 229 SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPP 288
            AG G         +   + L  PA+  P   G  + P  P QP      + +P    PP
Sbjct: 453 QAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPP--PQQPGSAKPPSQQPGSTKPP 510

Query: 289 RKDAAPALG----PLSSSPLATPSPSAALQSQAP-PTLPATPHSSSLTCQLATPLPLAPP 343
            +   PA      P S+ P +    SA   +Q P P  P+   S+    Q  +  PL PP
Sbjct: 511 PQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPP 570

Query: 344 SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP 403
           + S  PS +        PPSQ       P    T   L  P  +   T         +L 
Sbjct: 571 TVS--PSAKQ-------PPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLC 621

Query: 404 PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPS 463
                P+P  +     L   + Q   AL   L   P SP P            + PV+ +
Sbjct: 622 GFN--PNPHLTEVKEWLCL-NCQMKRALGGDLAPVPSSPQPKLK---------TAPVTTT 669

Query: 464 ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA------APPLQLAKPPP 517
           +     +P      P Q  P   A+P    S  P P+ PPPL         P   AK PP
Sbjct: 670 SAVSKSSPQ-----PQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPP 724

Query: 518 Q-------APPALATPPLQALPSPPASFPGQAP--FSPSASLPMSPLATPPPQAPPVLAA 568
           +       APP   + P +   +P A    + P    P+  L  S  AT  P  P     
Sbjct: 725 EADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQ 784

Query: 569 PLLQVPPSPPASPTLQAPRR--PPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP 626
              +   +PP       P +  PPT        G +++   +   P P S S   +  GP
Sbjct: 785 SQAEEKTTPPLKTDSAKPSQSFPPT--------GEKVSPFDSKAIPRPASDSKIISHPGP 836

Query: 627 DLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPG 686
                 S      + ++  +   +     SP PDA+            P P    +G+P 
Sbjct: 837 ---SSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAK------------PMP----KGSPT 877

Query: 687 APLPWPPA 694
            P P P A
Sbjct: 878 PPGPRPTA 885



 Score =  112 bits (280), Expect = 1e-24
 Identities = 151/579 (26%), Positives = 202/579 (34%), Gaps = 74/579 (12%)

Query: 96  ASGRGERAPP---AKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEE----TVARGKAT 148
           AS  GE  P    A   + G  S  G  S T  P  +     ++S EE         +A 
Sbjct: 5   ASLEGEGLPEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQ 64

Query: 149 EAPKRSALSAGARRDT---------------SG--PTPGTPSPAMARRSRAAGT---EVG 188
             PK S   A A   +               SG  P PG P+     +SR   T   E  
Sbjct: 65  GLPKGSVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQK 124

Query: 189 LPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATP 248
           LP  +PS      +    KS +   E   +   P      +A       A  S+ +   P
Sbjct: 125 LPGRSPSTISLKES----KSRTDLKEEHKSSMMPGFLSEVNA-----LSAVSSVVNKFNP 175

Query: 249 LSSPARSGPSARGTPRAP--AHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLAT 306
               + S  S   T +        Q KP+G+  ++PP    P K      GP    PL  
Sbjct: 176 FDLISDSEASQEETTKKQKVVQKEQGKPEGI--IKPPLQQQPPKPIPKQQGP-GRDPLQQ 232

Query: 307 PSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAT 366
                ++ SQ P  + + P  +    Q  T     P +  A   LQ   S P T   QA 
Sbjct: 233 DGTPKSISSQQPEKIKSQPPGTGKPIQGPTQ---TPQTDHAKLPLQRDASRPQT--KQAD 287

Query: 367 TSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSP--LATPS 424
              G    ++    LPSP   P+  P P  PPA      ++ P P A PP  P  L  P 
Sbjct: 288 IVRG----ESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGP-AKPPAQPSGLTKPL 342

Query: 425 PQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPS 484
            Q P  +   +     + PP+ P+  P  PPA    S   +     P +LA PP  V  +
Sbjct: 343 AQQPGTVKPPVQPPGTTKPPAQPL-GPAKPPAQQTGSEKPSSEQPGPKALAQPP-GVGKT 400

Query: 485 P-----PASPPMSPSATPPPQAPPPLAAPPLQLAKP---PPQAPPALATPPLQALPS--- 533
           P     PA PP     TP P A  P    P +   P   P Q P     P  QA P    
Sbjct: 401 PAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTS 460

Query: 534 --------PPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585
                   PP+  PG A   P    P  P    P  A P    P    PP     P   +
Sbjct: 461 AQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPS 520

Query: 586 PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLS 624
           P++P +  P +   G     A  P P  P ++  +  +S
Sbjct: 521 PQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVS 559



 Score =  111 bits (277), Expect = 3e-24
 Identities = 175/697 (25%), Positives = 254/697 (36%), Gaps = 137/697 (19%)

Query: 17  PAARAPGLLTP--RPPGSPRPPP-PVTPAALRVLGAAGAVGRKPLAERAG--------GI 65
           P A+ PG + P  +PPG+ +PP  P+ PA      A      KP +E+ G        G+
Sbjct: 341 PLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPP---AQQTGSEKPSSEQPGPKALAQPPGV 397

Query: 66  GGATIPESAPRAGPTRSAGTS---SRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASG 122
           G     +  P   PT+  GT    ++ P  + PA   G    P +   PGP   P + +G
Sbjct: 398 GKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQ--PGPGKIPAQQAG 455

Query: 123 TTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA 182
              PG       + SA++T      T+ P  S L   A+     P P  P P     ++ 
Sbjct: 456 ---PG-------KTSAQQT----GPTKPP--SQLPGPAKPPPQQPGPAKPPPQQPGSAKP 499

Query: 183 AGTEVGLPRPAPS----ARPRPPTEGPRKSVSS---ASEHSTTEPSPAARRRPSAGGGLQ 235
              + G  +P P     A+P P   G  K  S    +++ S  +PSPA   +PSA     
Sbjct: 500 PSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPA---KPSAQQST- 555

Query: 236 RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPA 295
           +P S++   S  PL  P  S       P A   PSQ  PK    + P   T       P 
Sbjct: 556 KPVSQT--GSGKPLQPPTVS-------PSAKQPPSQGLPK---TICPLCNTTELLLHVPE 603

Query: 296 LGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPL--PLAPPSPSAPPSLQT 353
               ++      +  +       P L        L CQ+   L   LAP   S  P L+T
Sbjct: 604 KANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKT 663

Query: 354 LPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA-TPPPQAPPALALPPL------- 405
            P    +  S++     SP  Q T     + P   L+  P P+ PP L   P        
Sbjct: 664 APVTTTSAVSKS-----SPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSA 718

Query: 406 ---QAP-------PSPPASPPL------SPLATPSPQAPNALA-----VHLLQAPFSPP- 443
              Q P       P+PP  P +      +P+A   P+ P  +      V    A   P  
Sbjct: 719 KAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDI 778

Query: 444 PSPPVQAPFSPPASPPVSPSATPPSQA-PPS---LAAPPLQVPPSPPASPPMSPSATPPP 499
           PS  VQ+      +PP+   +  PSQ+ PP+   ++    +  P P +   +     P  
Sbjct: 779 PSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSS 838

Query: 500 QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPP 559
           ++       P+Q  + P +A   ++  P  A P P  S       +P    P +    P 
Sbjct: 839 ESKGQKQVDPVQKKEEPKKAQTKMSPKP-DAKPMPKGSP------TPPGPRPTAGQTVPT 891

Query: 560 PQAPP----------VLAAPLLQVPPSPPASPT---------------LQAPRRPPT--- 591
           PQ  P          +    +   P S P +P                 QA     T   
Sbjct: 892 PQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQ 951

Query: 592 PGPDTSVSGPRLTLALAPGPPPPPSRS--PSSTLSGP 626
           PGP  S SGP   +  AP P  PP+    P ST   P
Sbjct: 952 PGPH-SQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAP 987



 Score =  100 bits (250), Expect = 4e-21
 Identities = 171/634 (26%), Positives = 223/634 (35%), Gaps = 103/634 (16%)

Query: 138 AEETVARGKATEA--PKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPS 195
           A    A G A+ A  P  +A+ AG   D S  +        A  SRA G   G   PA +
Sbjct: 17  AAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPPAAA 76

Query: 196 ARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARS 255
             P         S+    E  ++ P   + R P  G    RPA   LS S T  +   RS
Sbjct: 77  ESP---------SMHRKQELDSSHPPKQSGRPPDPG----RPAQPGLSKSRT--TDTFRS 121

Query: 256 GPSARGTPRAPAHPSQPKPKGLQALRPPQ---VTPPRKDAAPALGPLSS-----SPLATP 307
                G  R+P+  S  + K    L+      + P       AL  +SS     +P    
Sbjct: 122 EQKLPG--RSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLI 179

Query: 308 SPSAALQSQAPPTLPATPHSSSLTCQLATPLPLA-PPSPSAPPSLQTLPSPPATPPSQAT 366
           S S A Q +       T     +  +   P  +  PP    PP        P   P Q  
Sbjct: 180 SDSEASQEET------TKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQD 233

Query: 367 TSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLAT-PSP 425
              G+P      S     P    + PP    P     P Q P +  A  PL   A+ P  
Sbjct: 234 ---GTPK-----SISSQQPEKIKSQPPGTGKPIQG--PTQTPQTDHAKLPLQRDASRPQT 283

Query: 426 QAPNALAVHLLQAPFSPPPSPPVQAPF--SPPASPPVSPSATP-PSQAP--PSLAAPPLQ 480
           +  + +    ++     P  PP+Q P    PPA  P    + P P++ P  PS    PL 
Sbjct: 284 KQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLA 343

Query: 481 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLA---KPPPQ--APPALATPPLQALPSPP 535
             P     P   P  T PP  P   A PP Q     KP  +   P ALA PP   +   P
Sbjct: 344 QQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPP--GVGKTP 401

Query: 536 ASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGP- 594
           A  PG  P  P    P   + TP P A      P LQ P   P  PT + P + P PG  
Sbjct: 402 AQQPG--PAKP----PTQQVGTPKPLAQQ----PGLQSPAKAPG-PT-KTPVQQPGPGKI 449

Query: 595 DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAA 654
               +GP  T A   GP  PPS+ P     GP        A   P++      GP     
Sbjct: 450 PAQQAGPGKTSAQQTGPTKPPSQLP-----GP--------AKPPPQQ-----PGP----- 486

Query: 655 ASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPES 714
           A PPP    +A  P+       PP    G P  P P  P +         T   ++ P S
Sbjct: 487 AKPPPQQPGSAKPPSQQPGSTKPPPQQPG-PAKPSPQQPGS---------TKPPSQQPGS 536

Query: 715 ATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSP 748
           A P+     P         K  +  G+G   + P
Sbjct: 537 AKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPP 570



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 132/598 (22%), Positives = 199/598 (33%), Gaps = 97/598 (16%)

Query: 4    KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63
            K    + G+    P    P   +P+ PGS +PP     +A     A      KP A+++ 
Sbjct: 498  KPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKP--SAQQPSPAKPSAQQS- 554

Query: 64   GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGT 123
                 T P S   +G      T S + A +PP+ G  +   P  NT+   +  P +A+  
Sbjct: 555  -----TKPVSQTGSGKPLQPPTVSPS-AKQPPSQGLPKTICPLCNTTELLLHVPEKANFN 608

Query: 124  TRPGPLGQKGLRISAEETVA-------RGKATEAPKRSALSAGARRDTSG---PTPGTPS 173
            T              + TV            TE  +   L+   +R   G   P P +P 
Sbjct: 609  TCT----------ECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQ 658

Query: 174  PAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEP---SPAARRRPSA 230
            P +        + V    P P          P++ +S A E     P    P     PSA
Sbjct: 659  PKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSA 718

Query: 231  GGGLQRPASRSLSSSATP----LSSPARSGPSARGTPRAP----------------AHPS 270
                Q P + SLS  A P    + S     P A   P+ P                  P 
Sbjct: 719  KAK-QPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPD 777

Query: 271  QPKPKGLQALRPPQVTPPRK--DAAPA---------LGPLSSSPLATPSPSAALQSQAPP 319
             P  K +Q+    + TPP K   A P+         + P  S  +  P+  + + S   P
Sbjct: 778  IPSSK-VQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGP 836

Query: 320  TL----------------PATPHSSSLTCQLATPLPLAPPSPSAPPSL--QTLPSPPATP 361
            +                 P    +       A P+P   P+P  P     QT+P+P  +P
Sbjct: 837  SSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSP 896

Query: 362  PSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLA 421
              Q  +   S  L +      S P +P  T   +      L    A     AS  +S   
Sbjct: 897  KPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGK------LFGFGASIFSQASNLISTAG 950

Query: 422  TPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV 481
             P P + +     + QAP    P      P S   +PP    + P  +   + AA  L+ 
Sbjct: 951  QPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLE- 1009

Query: 482  PPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP 539
               P A    +   T   + PPP+       A+P     P      L+  P P ++ P
Sbjct: 1010 ---PKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPT----KLEKSPKPESTCP 1060



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 88/346 (25%), Positives = 128/346 (36%), Gaps = 52/346 (15%)

Query: 309  PSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTS 368
            PS+ +       L  T  +S  T     P   A   PS  PS+ +LP+ P   P   ++S
Sbjct: 2344 PSSVIALPMKEQLSTTYFTSGETFGQEKP---ASQLPSGSPSVSSLPAKPR--PFFRSSS 2398

Query: 369  LGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQ-- 426
            L         S  P PP  P   PPP  PP         PP PP  PP SP  T  P+  
Sbjct: 2399 LDI-------SAQPPPPPPPPPPPPPPPPP---------PPPPPLPPPTSPKPTILPKKK 2442

Query: 427  ----APNALAVHLLQAPFSPPPSPPVQAPFSP------PASPPVSPSATPPSQAPPSLAA 476
                +P   A  L  A  +   +  +++   P       A PPV P    PS  P  L  
Sbjct: 2443 LTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPK---PSSIPSGLVF 2499

Query: 477  PPLQVPPSPPASP-PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPP 535
                 P  PP +P P+ P      Q P  +   P  L+         L T     LPSP 
Sbjct: 2500 THRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMT-LNLVTSADYKLPSP- 2557

Query: 536  ASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPD 595
                  +P SP ++       + P  +  +    ++   PS P +PT  +  +  T  P 
Sbjct: 2558 -----TSPLSPHSN------KSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAITSWPL 2606

Query: 596  TSVSGPRLTL--ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTP 639
             S S   +++    +  PP      P S+     ++G   + ++TP
Sbjct: 2607 GSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATP 2652



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 89/355 (25%), Positives = 127/355 (35%), Gaps = 64/355 (18%)

Query: 282  PPQ--VTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPP--TLPATPH----SSSLTCQ 333
            PP   +  P K+        S        P++ L S +P   +LPA P     SSSL   
Sbjct: 2343 PPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDIS 2402

Query: 334  LATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP 393
             A P P  PP P  PP     P PP  PP                  LP PP SP  T  
Sbjct: 2403 -AQPPPPPPPPPPPPPP----PPPPPPPP------------------LP-PPTSPKPTIL 2438

Query: 394  PQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF- 452
            P+    +A P   A P   A   ++ L T +    N L V  +    +PPP PP  +   
Sbjct: 2439 PKKKLTVASPVTTATPLFDA---VTTLETTAVLRSNGLPVTRI-CTTAPPPVPPKPSSIP 2494

Query: 453  --------SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP-----PASPPMSPSATPPP 499
                      P+ PP++P    P    P+    P  + P P      +S  ++   +   
Sbjct: 2495 SGLVFTHRPEPSKPPIAPKPVIPQL--PTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADY 2552

Query: 500  QAPPPLAAPPLQLAKPPPQAPPALA-TPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 558
            + P P +       K  P+   +L  T  +  LPS P +       S S ++   PL +P
Sbjct: 2553 KLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGT---PTDSSASQAITSWPLGSP 2609

Query: 559  PPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPP 613
                    +  L+ V P     P + A   P +      +SG   T +  P   P
Sbjct: 2610 --------SKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVTAP 2656



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 96/372 (25%), Positives = 136/372 (36%), Gaps = 60/372 (16%)

Query: 233  GLQRPASRSLSSSATPLSSPARSGPSARGTP-RAPAHPSQPKPKGLQALRPPQVTPPRKD 291
            G ++PAS+  S S +  S PA+  P  R +     A P  P P       PP   PP   
Sbjct: 2368 GQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPP------PPPPPPPPPP 2421

Query: 292  AAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSL 351
              P   P  +SP  T  P   L + A P   ATP   ++T  L T   L   S   P + 
Sbjct: 2422 PPPPPLPPPTSPKPTILPKKKL-TVASPVTTATPLFDAVT-TLETTAVLR--SNGLPVTR 2477

Query: 352  QTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAP--PALALPPLQAPP 409
                +PP  PP  ++   G   L  TH   P P   P+A P P  P  P     P    P
Sbjct: 2478 ICTTAPPPVPPKPSSIPSG---LVFTHR--PEPSKPPIA-PKPVIPQLPTTTQKPTDIHP 2531

Query: 410  SPPASPPLSPLATPSPQAPNAL--AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT-- 465
             P      + L+  S    N +  A + L +P SP       +P S  +SP  S S T  
Sbjct: 2532 KP------TGLSLTSSMTLNLVTSADYKLPSPTSP------LSPHSNKSSPRFSKSLTET 2579

Query: 466  ------PPSQAPPSLAAPPLQVPPSPPASPPMS-PSATPPPQAPPPLAAPPLQLAKPPP- 517
                  P     P+ ++    +   P  SP     S  P     PP+ A  + ++     
Sbjct: 2580 YVVITLPSEPGTPTDSSASQAITSWPLGSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTF 2639

Query: 518  ---------QAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV-LA 567
                      A P  A    QA P+    F        +  +  + ++     AP V L+
Sbjct: 2640 YISGALQTFSATPVTAPSSFQAAPTSVTQF-------LTTEVSKTEVSATRSTAPSVGLS 2692

Query: 568  APLLQVPPSPPA 579
            +  + +PP P A
Sbjct: 2693 SISITIPPEPLA 2704



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 71/296 (23%), Positives = 101/296 (34%), Gaps = 58/296 (19%)

Query: 169  PGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSAS--------EHSTTEP 220
            P  P P     S     +   P P P   P PP   P   +   +        +   T  
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVA 2446

Query: 221  SPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQAL 280
            SP     P          +  L S+  P++    + P     P  P  PS   P GL   
Sbjct: 2447 SPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAP-----PPVPPKPSS-IPSGLVFT 2500

Query: 281  RPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPH----SSSLTCQLAT 336
              P+ + P         P++  P+    P+    +Q P  +   P     +SS+T  L T
Sbjct: 2501 HRPEPSKP---------PIAPKPVIPQLPTT---TQKPTDIHPKPTGLSLTSSMTLNLVT 2548

Query: 337  PLPLAPPSPSAPPS-------------------LQTLPSPPATP----PSQATTS--LGS 371
                  PSP++P S                   + TLPS P TP     SQA TS  LGS
Sbjct: 2549 SADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAITSWPLGS 2608

Query: 372  PT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPS 424
            P+   +     F   PP++ +  P            LQ   + P + P S  A P+
Sbjct: 2609 PSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAAPT 2664



 Score = 34.7 bits (78), Expect = 0.39
 Identities = 38/141 (26%), Positives = 55/141 (39%), Gaps = 10/141 (7%)

Query: 406  QAPPSPPASPPLSPLATPSP----QAPNALAVHLLQAPFSPPPSPPV-QAPFSPPASPPV 460
            Q+P    A+ P      P+P     + +  A   +Q   SPP SP V  +P SP +    
Sbjct: 3576 QSPQYLSATSPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKA 3635

Query: 461  SPSATPPSQAP-PSLAAPPLQVPPS----PPASPPMSPSATPPPQAPPPLAAPPLQLAKP 515
              SA  P + P P   +P   + P     PPASP  +         P PL+    + ++ 
Sbjct: 3636 LESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRA 3695

Query: 516  PPQAPPALATPPLQALPSPPA 536
            P Q      T   Q + S  A
Sbjct: 3696 PFQYTEGYTTKGSQTMTSSGA 3716



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 93/391 (23%), Positives = 126/391 (32%), Gaps = 79/391 (20%)

Query: 18   AARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRA 77
            +A+ P    P PP  P PPPP  P           +  K     A  +  AT    A   
Sbjct: 2402 SAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTT 2461

Query: 78   GPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 137
              T +   S+  P +R   +     APP     P P S P     T RP P         
Sbjct: 2462 LETTAVLRSNGLPVTRICTT-----APPP--VPPKPSSIPSGLVFTHRPEP--------- 2505

Query: 138  AEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSAR 197
                    K   APK   +       T  PT   P P     S  +   + L   A    
Sbjct: 2506 -------SKPPIAPK--PVIPQLPTTTQKPTDIHPKP--TGLSLTSSMTLNLVTSADYKL 2554

Query: 198  PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGP 257
            P P         S  S HS  + SP                S+SL+ +   ++      P
Sbjct: 2555 PSP--------TSPLSPHS-NKSSPR--------------FSKSLTETYVVITL-----P 2586

Query: 258  SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQA 317
            S  GTP              QA+    +  P KD       +S  P+ +  P        
Sbjct: 2587 SEPGTP--------TDSSASQAITSWPLGSPSKDL------VSVEPVFSVVP-------- 2624

Query: 318  PPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQAT 377
            P T    P SS  T  ++  L     +P   PS  +  + P +     TT +    + AT
Sbjct: 2625 PVTAVEIPISSEQTFYISGALQTFSATPVTAPS--SFQAAPTSVTQFLTTEVSKTEVSAT 2682

Query: 378  HSFLPSPPLSPLATPPPQAPPALALPPLQAP 408
             S  PS  LS ++   P  P AL    L+ P
Sbjct: 2683 RSTAPSVGLSSISITIPPEPLALDNIHLEKP 2713



 Score = 33.5 bits (75), Expect = 0.86
 Identities = 32/125 (25%), Positives = 46/125 (36%), Gaps = 3/125 (2%)

Query: 441  SPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQ 500
            S   SP   +  SPP      P+      +    A   +Q+ PSPP SP +  S   P  
Sbjct: 3573 SDTQSPQYLSATSPPKDKK-RPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLS 3631

Query: 501  APPPLAAPPLQLAKPPPQ--APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 558
                L +  +   KP P   +P  +  P +  +P            S S   P+SP A  
Sbjct: 3632 PGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADE 3691

Query: 559  PPQAP 563
              +AP
Sbjct: 3692 SSRAP 3696



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 39/152 (25%), Positives = 50/152 (32%), Gaps = 18/152 (11%)

Query: 324  TPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPS 383
            T    SL CQ          S +  P   +  SPP          +G        S L +
Sbjct: 3559 TYKGGSLGCQTEAD------SDTQSPQYLSATSPPKDKKRPTPLEIGYS------SHLRA 3606

Query: 384  PPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 443
                 LA  PP++P  L  P     P         P   P P   +   V        PP
Sbjct: 3607 DSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPP 3666

Query: 444  PSPP----VQAPFSPPASPPVSPSATPPSQAP 471
             SP     +Q   S P   P+SP+A   S+AP
Sbjct: 3667 ASPKTAKMMQRSMSDP--KPLSPTADESSRAP 3696



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 37/141 (26%), Positives = 52/141 (36%), Gaps = 22/141 (15%)

Query: 299  LSSSPLATPSPSAALQSQ----APPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTL 354
            +S S +++  P+  ++SQ     P T P T  S  +  Q  T   L PP+    P  Q  
Sbjct: 3834 MSDSEVSSTRPTR-IESQHGIERPRTAPQTEFSQFIPPQTQTESQLVPPT---SPYTQYQ 3889

Query: 355  PSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPAS 414
             S PA P             QA  S+              Q  P    P  QA  +   +
Sbjct: 3890 YSSPALP------------TQAPTSYTQQSHFEQQTLYHQQVSPYQTQPTFQAVATMSFT 3937

Query: 415  PPLSPLATPSP--QAPNALAV 433
            P + P  TP P  Q P+ + V
Sbjct: 3938 PQVQPTPTPQPSYQLPSQMMV 3958


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score =  124 bits (312), Expect = 3e-28
 Identities = 173/626 (27%), Positives = 225/626 (35%), Gaps = 98/626 (15%)

Query: 31  GSPRPPPPVTPAALRV-LGAAGAVGRKPLA---ERAGGIGGATIPESAPRAGPTRSAGTS 86
           G+  P     PA +   L       R+ +A    RA G+   ++P   P A  + S    
Sbjct: 28  GAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP---PAAAESPSMHRK 84

Query: 87  SRNPASRPPA-SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL--GQKGLRISAEETVA 143
               +S PP  SGR    PP       P  S  R + T R      G+    IS +E+ +
Sbjct: 85  QELDSSHPPKQSGR----PPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKS 140

Query: 144 RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 203
           R    E  K S +            PG  S   A    A  + V    P           
Sbjct: 141 RTDLKEEHKSSMM------------PGFLSEVNALS--AVSSVVNKFNPFDLI------- 179

Query: 204 GPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTP 263
               S S AS+  TT+     ++      G+ +P  +           P +  P  +G  
Sbjct: 180 ----SDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQ---------QPPKPIPKQQGPG 226

Query: 264 RAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPS-AALQSQAPPTLP 322
           R P       PK + + +P ++    K   P  G     P  TP    A L  Q   + P
Sbjct: 227 RDPLQ-QDGTPKSISSQQPEKI----KSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRP 281

Query: 323 ATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPS-PPATPPSQATTSLGSPTLQATHSFL 381
            T  +  +  +   P   + PSPS PP  Q  P  PPA  P    +  G     A  S L
Sbjct: 282 QTKQADIVRGESVKP---SLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGL 338

Query: 382 PSP-PLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQA----PNALA---- 432
             P    P    PP  PP    PP Q  P  PA PP     +  P +    P ALA    
Sbjct: 339 TKPLAQQPGTVKPPVQPPGTTKPPAQ--PLGPAKPPAQQTGSEKPSSEQPGPKALAQPPG 396

Query: 433 VHLLQAPFSPPPSPPVQAPFSP-----------PASPPVSPSATPPSQAPPSLAAPPLQV 481
           V    A    P  PP Q   +P           PA  P  P+ TP  Q  P    P  Q 
Sbjct: 397 VGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAP-GPTKTPVQQPGPG-KIPAQQA 454

Query: 482 PPSPPASPPMSPSATPPPQAPPPLAAPPLQL--AKPPPQAPPALATPPLQALPS--PPAS 537
            P   ++    P+  PP Q P P   PP Q   AKPPPQ P + A PP Q   S  PP  
Sbjct: 455 GPGKTSAQQTGPTK-PPSQLPGPAKPPPQQPGPAKPPPQQPGS-AKPPSQQPGSTKPPPQ 512

Query: 538 FPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTS 597
            PG  P  PS   P  P +T PP   P  A P  Q P   PA P+ Q   +P +    T 
Sbjct: 513 QPG--PAKPS---PQQPGSTKPPSQQPGSAKPSAQQPS--PAKPSAQQSTKPVS---QTG 562

Query: 598 VSGPRLTLALAPGPPPPPSRSPSSTL 623
              P     ++P    PPS+    T+
Sbjct: 563 SGKPLQPPTVSPSAKQPPSQGLPKTI 588



 Score =  117 bits (294), Expect = 3e-26
 Identities = 175/728 (24%), Positives = 262/728 (35%), Gaps = 107/728 (14%)

Query: 5   RDKAKAGAAARTPAARAPGLLTPRPPGSPRP--PPPVTPAALRVLGAAGAVGRKPLAERA 62
           RD  +     ++ +++ P  +  +PPG+ +P   P  TP              +P  ++A
Sbjct: 227 RDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQA 286

Query: 63  GGIGGATIPESAPRAG-PTRSAGTSSRNPASRP--PASGRGERAPPAKNTS--------P 111
             + G ++  S P    P     T  + PA +P    S  G   PPA+ +         P
Sbjct: 287 DIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQP 346

Query: 112 GPVSSPGRASGTTRPG--PLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTP 169
           G V  P +  GTT+P   PLG    +  A++T +   ++E P   AL   A+    G TP
Sbjct: 347 GTVKPPVQPPGTTKPPAQPLGPA--KPPAQQTGSEKPSSEQPGPKAL---AQPPGVGKTP 401

Query: 170 GT-PSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRP 228
              P PA     +    +VG P+P      +P  + P K+    ++    +P P      
Sbjct: 402 AQQPGPA-----KPPTQQVGTPKPLAQ---QPGLQSPAKA-PGPTKTPVQQPGPGKIPAQ 452

Query: 229 SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPP 288
            AG G         +   + L  PA+  P   G  + P  P QP      + +P    PP
Sbjct: 453 QAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPP--PQQPGSAKPPSQQPGSTKPP 510

Query: 289 RKDAAPALG----PLSSSPLATPSPSAALQSQAP-PTLPATPHSSSLTCQLATPLPLAPP 343
            +   PA      P S+ P +    SA   +Q P P  P+   S+    Q  +  PL PP
Sbjct: 511 PQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPP 570

Query: 344 SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP 403
           + S  PS +        PPSQ       P    T   L  P  +   T         +L 
Sbjct: 571 TVS--PSAKQ-------PPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLC 621

Query: 404 PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPS 463
                P+P  +     L   + Q   AL   L   P SP P            + PV+ +
Sbjct: 622 GFN--PNPHLTEVKEWLCL-NCQMKRALGGDLAPVPSSPQPKLK---------TAPVTTT 669

Query: 464 ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA------APPLQLAKPPP 517
           +     +P      P Q  P   A+P    S  P P+ PPPL         P   AK PP
Sbjct: 670 SAVSKSSPQ-----PQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPP 724

Query: 518 Q-------APPALATPPLQALPSPPASFPGQAP--FSPSASLPMSPLATPPPQAPPVLAA 568
           +       APP   + P +   +P A    + P    P+  L  S  AT  P  P     
Sbjct: 725 EADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQ 784

Query: 569 PLLQVPPSPPASPTLQAPRR--PPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP 626
              +   +PP       P +  PPT        G +++   +   P P S S   +  GP
Sbjct: 785 SQAEEKTTPPLKTDSAKPSQSFPPT--------GEKVSPFDSKAIPRPASDSKIISHPGP 836

Query: 627 DLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPG 686
                 S      + ++  +   +     SP PDA+            P P    +G+P 
Sbjct: 837 ---SSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAK------------PMP----KGSPT 877

Query: 687 APLPWPPA 694
            P P P A
Sbjct: 878 PPGPRPTA 885



 Score =  112 bits (280), Expect = 1e-24
 Identities = 151/579 (26%), Positives = 202/579 (34%), Gaps = 74/579 (12%)

Query: 96  ASGRGERAPP---AKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEE----TVARGKAT 148
           AS  GE  P    A   + G  S  G  S T  P  +     ++S EE         +A 
Sbjct: 5   ASLEGEGLPEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQ 64

Query: 149 EAPKRSALSAGARRDT---------------SG--PTPGTPSPAMARRSRAAGT---EVG 188
             PK S   A A   +               SG  P PG P+     +SR   T   E  
Sbjct: 65  GLPKGSVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQK 124

Query: 189 LPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATP 248
           LP  +PS      +    KS +   E   +   P      +A       A  S+ +   P
Sbjct: 125 LPGRSPSTISLKES----KSRTDLKEEHKSSMMPGFLSEVNA-----LSAVSSVVNKFNP 175

Query: 249 LSSPARSGPSARGTPRAP--AHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLAT 306
               + S  S   T +        Q KP+G+  ++PP    P K      GP    PL  
Sbjct: 176 FDLISDSEASQEETTKKQKVVQKEQGKPEGI--IKPPLQQQPPKPIPKQQGP-GRDPLQQ 232

Query: 307 PSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAT 366
                ++ SQ P  + + P  +    Q  T     P +  A   LQ   S P T   QA 
Sbjct: 233 DGTPKSISSQQPEKIKSQPPGTGKPIQGPTQ---TPQTDHAKLPLQRDASRPQT--KQAD 287

Query: 367 TSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSP--LATPS 424
              G    ++    LPSP   P+  P P  PPA      ++ P P A PP  P  L  P 
Sbjct: 288 IVRG----ESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGP-AKPPAQPSGLTKPL 342

Query: 425 PQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPS 484
            Q P  +   +     + PP+ P+  P  PPA    S   +     P +LA PP  V  +
Sbjct: 343 AQQPGTVKPPVQPPGTTKPPAQPL-GPAKPPAQQTGSEKPSSEQPGPKALAQPP-GVGKT 400

Query: 485 P-----PASPPMSPSATPPPQAPPPLAAPPLQLAKP---PPQAPPALATPPLQALPS--- 533
           P     PA PP     TP P A  P    P +   P   P Q P     P  QA P    
Sbjct: 401 PAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTS 460

Query: 534 --------PPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585
                   PP+  PG A   P    P  P    P  A P    P    PP     P   +
Sbjct: 461 AQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPS 520

Query: 586 PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLS 624
           P++P +  P +   G     A  P P  P ++  +  +S
Sbjct: 521 PQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVS 559



 Score =  111 bits (277), Expect = 3e-24
 Identities = 175/697 (25%), Positives = 254/697 (36%), Gaps = 137/697 (19%)

Query: 17  PAARAPGLLTP--RPPGSPRPPP-PVTPAALRVLGAAGAVGRKPLAERAG--------GI 65
           P A+ PG + P  +PPG+ +PP  P+ PA      A      KP +E+ G        G+
Sbjct: 341 PLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPP---AQQTGSEKPSSEQPGPKALAQPPGV 397

Query: 66  GGATIPESAPRAGPTRSAGTS---SRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASG 122
           G     +  P   PT+  GT    ++ P  + PA   G    P +   PGP   P + +G
Sbjct: 398 GKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQ--PGPGKIPAQQAG 455

Query: 123 TTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA 182
              PG       + SA++T      T+ P  S L   A+     P P  P P     ++ 
Sbjct: 456 ---PG-------KTSAQQT----GPTKPP--SQLPGPAKPPPQQPGPAKPPPQQPGSAKP 499

Query: 183 AGTEVGLPRPAPS----ARPRPPTEGPRKSVSS---ASEHSTTEPSPAARRRPSAGGGLQ 235
              + G  +P P     A+P P   G  K  S    +++ S  +PSPA   +PSA     
Sbjct: 500 PSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPA---KPSAQQST- 555

Query: 236 RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPA 295
           +P S++   S  PL  P  S       P A   PSQ  PK    + P   T       P 
Sbjct: 556 KPVSQT--GSGKPLQPPTVS-------PSAKQPPSQGLPK---TICPLCNTTELLLHVPE 603

Query: 296 LGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPL--PLAPPSPSAPPSLQT 353
               ++      +  +       P L        L CQ+   L   LAP   S  P L+T
Sbjct: 604 KANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKT 663

Query: 354 LPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA-TPPPQAPPALALPPL------- 405
            P    +  S++     SP  Q T     + P   L+  P P+ PP L   P        
Sbjct: 664 APVTTTSAVSKS-----SPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSA 718

Query: 406 ---QAP-------PSPPASPPL------SPLATPSPQAPNALA-----VHLLQAPFSPP- 443
              Q P       P+PP  P +      +P+A   P+ P  +      V    A   P  
Sbjct: 719 KAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDI 778

Query: 444 PSPPVQAPFSPPASPPVSPSATPPSQA-PPS---LAAPPLQVPPSPPASPPMSPSATPPP 499
           PS  VQ+      +PP+   +  PSQ+ PP+   ++    +  P P +   +     P  
Sbjct: 779 PSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSS 838

Query: 500 QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPP 559
           ++       P+Q  + P +A   ++  P  A P P  S       +P    P +    P 
Sbjct: 839 ESKGQKQVDPVQKKEEPKKAQTKMSPKP-DAKPMPKGSP------TPPGPRPTAGQTVPT 891

Query: 560 PQAPP----------VLAAPLLQVPPSPPASPT---------------LQAPRRPPT--- 591
           PQ  P          +    +   P S P +P                 QA     T   
Sbjct: 892 PQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQ 951

Query: 592 PGPDTSVSGPRLTLALAPGPPPPPSRS--PSSTLSGP 626
           PGP  S SGP   +  AP P  PP+    P ST   P
Sbjct: 952 PGPH-SQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAP 987



 Score =  100 bits (250), Expect = 4e-21
 Identities = 171/634 (26%), Positives = 223/634 (35%), Gaps = 103/634 (16%)

Query: 138 AEETVARGKATEA--PKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPS 195
           A    A G A+ A  P  +A+ AG   D S  +        A  SRA G   G   PA +
Sbjct: 17  AAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPPAAA 76

Query: 196 ARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARS 255
             P         S+    E  ++ P   + R P  G    RPA   LS S T  +   RS
Sbjct: 77  ESP---------SMHRKQELDSSHPPKQSGRPPDPG----RPAQPGLSKSRT--TDTFRS 121

Query: 256 GPSARGTPRAPAHPSQPKPKGLQALRPPQ---VTPPRKDAAPALGPLSS-----SPLATP 307
                G  R+P+  S  + K    L+      + P       AL  +SS     +P    
Sbjct: 122 EQKLPG--RSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLI 179

Query: 308 SPSAALQSQAPPTLPATPHSSSLTCQLATPLPLA-PPSPSAPPSLQTLPSPPATPPSQAT 366
           S S A Q +       T     +  +   P  +  PP    PP        P   P Q  
Sbjct: 180 SDSEASQEET------TKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQD 233

Query: 367 TSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLAT-PSP 425
              G+P      S     P    + PP    P     P Q P +  A  PL   A+ P  
Sbjct: 234 ---GTPK-----SISSQQPEKIKSQPPGTGKPIQG--PTQTPQTDHAKLPLQRDASRPQT 283

Query: 426 QAPNALAVHLLQAPFSPPPSPPVQAPF--SPPASPPVSPSATP-PSQAP--PSLAAPPLQ 480
           +  + +    ++     P  PP+Q P    PPA  P    + P P++ P  PS    PL 
Sbjct: 284 KQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLA 343

Query: 481 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLA---KPPPQ--APPALATPPLQALPSPP 535
             P     P   P  T PP  P   A PP Q     KP  +   P ALA PP   +   P
Sbjct: 344 QQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPP--GVGKTP 401

Query: 536 ASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGP- 594
           A  PG  P  P    P   + TP P A      P LQ P   P  PT + P + P PG  
Sbjct: 402 AQQPG--PAKP----PTQQVGTPKPLAQQ----PGLQSPAKAPG-PT-KTPVQQPGPGKI 449

Query: 595 DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAA 654
               +GP  T A   GP  PPS+ P     GP        A   P++      GP     
Sbjct: 450 PAQQAGPGKTSAQQTGPTKPPSQLP-----GP--------AKPPPQQ-----PGP----- 486

Query: 655 ASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPES 714
           A PPP    +A  P+       PP    G P  P P  P +         T   ++ P S
Sbjct: 487 AKPPPQQPGSAKPPSQQPGSTKPPPQQPG-PAKPSPQQPGS---------TKPPSQQPGS 536

Query: 715 ATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSP 748
           A P+     P         K  +  G+G   + P
Sbjct: 537 AKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPP 570



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 132/598 (22%), Positives = 199/598 (33%), Gaps = 97/598 (16%)

Query: 4    KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63
            K    + G+    P    P   +P+ PGS +PP     +A     A      KP A+++ 
Sbjct: 498  KPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKP--SAQQPSPAKPSAQQS- 554

Query: 64   GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGT 123
                 T P S   +G      T S + A +PP+ G  +   P  NT+   +  P +A+  
Sbjct: 555  -----TKPVSQTGSGKPLQPPTVSPS-AKQPPSQGLPKTICPLCNTTELLLHVPEKANFN 608

Query: 124  TRPGPLGQKGLRISAEETVA-------RGKATEAPKRSALSAGARRDTSG---PTPGTPS 173
            T              + TV            TE  +   L+   +R   G   P P +P 
Sbjct: 609  TCT----------ECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQ 658

Query: 174  PAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEP---SPAARRRPSA 230
            P +        + V    P P          P++ +S A E     P    P     PSA
Sbjct: 659  PKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSA 718

Query: 231  GGGLQRPASRSLSSSATP----LSSPARSGPSARGTPRAP----------------AHPS 270
                Q P + SLS  A P    + S     P A   P+ P                  P 
Sbjct: 719  KAK-QPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPD 777

Query: 271  QPKPKGLQALRPPQVTPPRK--DAAPA---------LGPLSSSPLATPSPSAALQSQAPP 319
             P  K +Q+    + TPP K   A P+         + P  S  +  P+  + + S   P
Sbjct: 778  IPSSK-VQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGP 836

Query: 320  TL----------------PATPHSSSLTCQLATPLPLAPPSPSAPPSL--QTLPSPPATP 361
            +                 P    +       A P+P   P+P  P     QT+P+P  +P
Sbjct: 837  SSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSP 896

Query: 362  PSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLA 421
              Q  +   S  L +      S P +P  T   +      L    A     AS  +S   
Sbjct: 897  KPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGK------LFGFGASIFSQASNLISTAG 950

Query: 422  TPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV 481
             P P + +     + QAP    P      P S   +PP    + P  +   + AA  L+ 
Sbjct: 951  QPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLE- 1009

Query: 482  PPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP 539
               P A    +   T   + PPP+       A+P     P      L+  P P ++ P
Sbjct: 1010 ---PKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPT----KLEKSPKPESTCP 1060



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 88/346 (25%), Positives = 128/346 (36%), Gaps = 52/346 (15%)

Query: 309  PSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTS 368
            PS+ +       L  T  +S  T     P   A   PS  PS+ +LP+ P   P   ++S
Sbjct: 2344 PSSVIALPMKEQLSTTYFTSGETFGQEKP---ASQLPSGSPSVSSLPAKPR--PFFRSSS 2398

Query: 369  LGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQ-- 426
            L         S  P PP  P   PPP  PP         PP PP  PP SP  T  P+  
Sbjct: 2399 LDI-------SAQPPPPPPPPPPPPPPPPP---------PPPPPLPPPTSPKPTILPKKK 2442

Query: 427  ----APNALAVHLLQAPFSPPPSPPVQAPFSP------PASPPVSPSATPPSQAPPSLAA 476
                +P   A  L  A  +   +  +++   P       A PPV P    PS  P  L  
Sbjct: 2443 LTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPK---PSSIPSGLVF 2499

Query: 477  PPLQVPPSPPASP-PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPP 535
                 P  PP +P P+ P      Q P  +   P  L+         L T     LPSP 
Sbjct: 2500 THRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMT-LNLVTSADYKLPSP- 2557

Query: 536  ASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPD 595
                  +P SP ++       + P  +  +    ++   PS P +PT  +  +  T  P 
Sbjct: 2558 -----TSPLSPHSN------KSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAITSWPL 2606

Query: 596  TSVSGPRLTL--ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTP 639
             S S   +++    +  PP      P S+     ++G   + ++TP
Sbjct: 2607 GSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATP 2652



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 89/355 (25%), Positives = 127/355 (35%), Gaps = 64/355 (18%)

Query: 282  PPQ--VTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPP--TLPATPH----SSSLTCQ 333
            PP   +  P K+        S        P++ L S +P   +LPA P     SSSL   
Sbjct: 2343 PPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDIS 2402

Query: 334  LATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP 393
             A P P  PP P  PP     P PP  PP                  LP PP SP  T  
Sbjct: 2403 -AQPPPPPPPPPPPPPP----PPPPPPPP------------------LP-PPTSPKPTIL 2438

Query: 394  PQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF- 452
            P+    +A P   A P   A   ++ L T +    N L V  +    +PPP PP  +   
Sbjct: 2439 PKKKLTVASPVTTATPLFDA---VTTLETTAVLRSNGLPVTRI-CTTAPPPVPPKPSSIP 2494

Query: 453  --------SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP-----PASPPMSPSATPPP 499
                      P+ PP++P    P    P+    P  + P P      +S  ++   +   
Sbjct: 2495 SGLVFTHRPEPSKPPIAPKPVIPQL--PTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADY 2552

Query: 500  QAPPPLAAPPLQLAKPPPQAPPALA-TPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 558
            + P P +       K  P+   +L  T  +  LPS P +       S S ++   PL +P
Sbjct: 2553 KLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGT---PTDSSASQAITSWPLGSP 2609

Query: 559  PPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPP 613
                    +  L+ V P     P + A   P +      +SG   T +  P   P
Sbjct: 2610 --------SKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVTAP 2656



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 96/372 (25%), Positives = 136/372 (36%), Gaps = 60/372 (16%)

Query: 233  GLQRPASRSLSSSATPLSSPARSGPSARGTP-RAPAHPSQPKPKGLQALRPPQVTPPRKD 291
            G ++PAS+  S S +  S PA+  P  R +     A P  P P       PP   PP   
Sbjct: 2368 GQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPP------PPPPPPPPPP 2421

Query: 292  AAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSL 351
              P   P  +SP  T  P   L + A P   ATP   ++T  L T   L   S   P + 
Sbjct: 2422 PPPPPLPPPTSPKPTILPKKKL-TVASPVTTATPLFDAVT-TLETTAVLR--SNGLPVTR 2477

Query: 352  QTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAP--PALALPPLQAPP 409
                +PP  PP  ++   G   L  TH   P P   P+A P P  P  P     P    P
Sbjct: 2478 ICTTAPPPVPPKPSSIPSG---LVFTHR--PEPSKPPIA-PKPVIPQLPTTTQKPTDIHP 2531

Query: 410  SPPASPPLSPLATPSPQAPNAL--AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT-- 465
             P      + L+  S    N +  A + L +P SP       +P S  +SP  S S T  
Sbjct: 2532 KP------TGLSLTSSMTLNLVTSADYKLPSPTSP------LSPHSNKSSPRFSKSLTET 2579

Query: 466  ------PPSQAPPSLAAPPLQVPPSPPASPPMS-PSATPPPQAPPPLAAPPLQLAKPPP- 517
                  P     P+ ++    +   P  SP     S  P     PP+ A  + ++     
Sbjct: 2580 YVVITLPSEPGTPTDSSASQAITSWPLGSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTF 2639

Query: 518  ---------QAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV-LA 567
                      A P  A    QA P+    F        +  +  + ++     AP V L+
Sbjct: 2640 YISGALQTFSATPVTAPSSFQAAPTSVTQF-------LTTEVSKTEVSATRSTAPSVGLS 2692

Query: 568  APLLQVPPSPPA 579
            +  + +PP P A
Sbjct: 2693 SISITIPPEPLA 2704



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 71/296 (23%), Positives = 101/296 (34%), Gaps = 58/296 (19%)

Query: 169  PGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSAS--------EHSTTEP 220
            P  P P     S     +   P P P   P PP   P   +   +        +   T  
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVA 2446

Query: 221  SPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQAL 280
            SP     P          +  L S+  P++    + P     P  P  PS   P GL   
Sbjct: 2447 SPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAP-----PPVPPKPSS-IPSGLVFT 2500

Query: 281  RPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPH----SSSLTCQLAT 336
              P+ + P         P++  P+    P+    +Q P  +   P     +SS+T  L T
Sbjct: 2501 HRPEPSKP---------PIAPKPVIPQLPTT---TQKPTDIHPKPTGLSLTSSMTLNLVT 2548

Query: 337  PLPLAPPSPSAPPS-------------------LQTLPSPPATP----PSQATTS--LGS 371
                  PSP++P S                   + TLPS P TP     SQA TS  LGS
Sbjct: 2549 SADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAITSWPLGS 2608

Query: 372  PT---LQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPS 424
            P+   +     F   PP++ +  P            LQ   + P + P S  A P+
Sbjct: 2609 PSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAAPT 2664



 Score = 34.7 bits (78), Expect = 0.39
 Identities = 38/141 (26%), Positives = 55/141 (39%), Gaps = 10/141 (7%)

Query: 406  QAPPSPPASPPLSPLATPSP----QAPNALAVHLLQAPFSPPPSPPV-QAPFSPPASPPV 460
            Q+P    A+ P      P+P     + +  A   +Q   SPP SP V  +P SP +    
Sbjct: 3576 QSPQYLSATSPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKA 3635

Query: 461  SPSATPPSQAP-PSLAAPPLQVPPS----PPASPPMSPSATPPPQAPPPLAAPPLQLAKP 515
              SA  P + P P   +P   + P     PPASP  +         P PL+    + ++ 
Sbjct: 3636 LESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRA 3695

Query: 516  PPQAPPALATPPLQALPSPPA 536
            P Q      T   Q + S  A
Sbjct: 3696 PFQYTEGYTTKGSQTMTSSGA 3716



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 93/391 (23%), Positives = 126/391 (32%), Gaps = 79/391 (20%)

Query: 18   AARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRA 77
            +A+ P    P PP  P PPPP  P           +  K     A  +  AT    A   
Sbjct: 2402 SAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTT 2461

Query: 78   GPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 137
              T +   S+  P +R   +     APP     P P S P     T RP P         
Sbjct: 2462 LETTAVLRSNGLPVTRICTT-----APPP--VPPKPSSIPSGLVFTHRPEP--------- 2505

Query: 138  AEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSAR 197
                    K   APK   +       T  PT   P P     S  +   + L   A    
Sbjct: 2506 -------SKPPIAPK--PVIPQLPTTTQKPTDIHPKP--TGLSLTSSMTLNLVTSADYKL 2554

Query: 198  PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGP 257
            P P         S  S HS  + SP                S+SL+ +   ++      P
Sbjct: 2555 PSP--------TSPLSPHS-NKSSPR--------------FSKSLTETYVVITL-----P 2586

Query: 258  SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQA 317
            S  GTP              QA+    +  P KD       +S  P+ +  P        
Sbjct: 2587 SEPGTP--------TDSSASQAITSWPLGSPSKDL------VSVEPVFSVVP-------- 2624

Query: 318  PPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQAT 377
            P T    P SS  T  ++  L     +P   PS  +  + P +     TT +    + AT
Sbjct: 2625 PVTAVEIPISSEQTFYISGALQTFSATPVTAPS--SFQAAPTSVTQFLTTEVSKTEVSAT 2682

Query: 378  HSFLPSPPLSPLATPPPQAPPALALPPLQAP 408
             S  PS  LS ++   P  P AL    L+ P
Sbjct: 2683 RSTAPSVGLSSISITIPPEPLALDNIHLEKP 2713



 Score = 33.5 bits (75), Expect = 0.86
 Identities = 32/125 (25%), Positives = 46/125 (36%), Gaps = 3/125 (2%)

Query: 441  SPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQ 500
            S   SP   +  SPP      P+      +    A   +Q+ PSPP SP +  S   P  
Sbjct: 3573 SDTQSPQYLSATSPPKDKK-RPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLS 3631

Query: 501  APPPLAAPPLQLAKPPPQ--APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 558
                L +  +   KP P   +P  +  P +  +P            S S   P+SP A  
Sbjct: 3632 PGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADE 3691

Query: 559  PPQAP 563
              +AP
Sbjct: 3692 SSRAP 3696



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 39/152 (25%), Positives = 50/152 (32%), Gaps = 18/152 (11%)

Query: 324  TPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPS 383
            T    SL CQ          S +  P   +  SPP          +G        S L +
Sbjct: 3559 TYKGGSLGCQTEAD------SDTQSPQYLSATSPPKDKKRPTPLEIGYS------SHLRA 3606

Query: 384  PPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 443
                 LA  PP++P  L  P     P         P   P P   +   V        PP
Sbjct: 3607 DSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPP 3666

Query: 444  PSPP----VQAPFSPPASPPVSPSATPPSQAP 471
             SP     +Q   S P   P+SP+A   S+AP
Sbjct: 3667 ASPKTAKMMQRSMSDP--KPLSPTADESSRAP 3696



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 37/141 (26%), Positives = 52/141 (36%), Gaps = 22/141 (15%)

Query: 299  LSSSPLATPSPSAALQSQ----APPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTL 354
            +S S +++  P+  ++SQ     P T P T  S  +  Q  T   L PP+    P  Q  
Sbjct: 3834 MSDSEVSSTRPTR-IESQHGIERPRTAPQTEFSQFIPPQTQTESQLVPPT---SPYTQYQ 3889

Query: 355  PSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPAS 414
             S PA P             QA  S+              Q  P    P  QA  +   +
Sbjct: 3890 YSSPALP------------TQAPTSYTQQSHFEQQTLYHQQVSPYQTQPTFQAVATMSFT 3937

Query: 415  PPLSPLATPSP--QAPNALAV 433
            P + P  TP P  Q P+ + V
Sbjct: 3938 PQVQPTPTPQPSYQLPSQMMV 3958


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.127    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,506,354
Number of Sequences: 37866
Number of extensions: 4993575
Number of successful extensions: 180804
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2047
Number of HSP's successfully gapped in prelim test: 3548
Number of HSP's that attempted gapping in prelim test: 24928
Number of HSP's gapped (non-prelim): 54003
length of query: 855
length of database: 18,247,518
effective HSP length: 111
effective length of query: 744
effective length of database: 14,044,392
effective search space: 10449027648
effective search space used: 10449027648
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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