Search of human proteins with 239756672

Search of human proteins with 239756672

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239756672 PREDICTED: hypothetical protein LOC146429 [Homo
sapiens]
         (495 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239756672 PREDICTED: hypothetical protein LOC146429 [Homo sap...   983   0.0  
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...   907   0.0  
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6...   898   0.0  
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   194   1e-49
gi|21361834 solute carrier family 22, member 17 isoform a [Homo ...   175   1e-43
gi|170650643 solute carrier family 22, member 23 isoform a [Homo...   153   4e-37
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           126   4e-29
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          120   2e-27
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   113   3e-25
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   113   5e-25
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          111   2e-24
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          107   2e-23
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           105   9e-23
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   102   1e-21
gi|48526516 solute carrier family 22, member 23 isoform b [Homo ...   101   2e-21
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]           97   3e-20
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...    93   6e-19
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...    91   2e-18
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...    91   2e-18
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...    91   2e-18
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...    87   3e-17
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]           84   4e-16
gi|166064021 solute carrier family 22 (organic anion transporter...    82   9e-16
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]        78   2e-14
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]         75   1e-13
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]        73   7e-13
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]        71   2e-12
gi|157426885 organic cation transporter like 4 [Homo sapiens]          69   1e-11
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]        62   9e-10
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]           57   3e-08

>gi|239756672 PREDICTED: hypothetical protein LOC146429 [Homo
           sapiens]
          Length = 495

 Score =  983 bits (2541), Expect = 0.0
 Identities = 495/495 (100%), Positives = 495/495 (100%)

Query: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60
           MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA
Sbjct: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60

Query: 61  LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPTWN 120
           LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPTWN
Sbjct: 61  LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPTWN 120

Query: 121 LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF 180
           LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF
Sbjct: 121 LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF 180

Query: 181 PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ 240
           PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ
Sbjct: 181 PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ 240

Query: 241 DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS 300
           DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS
Sbjct: 241 DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS 300

Query: 301 SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRANLPG 360
           SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRANLPG
Sbjct: 301 SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRANLPG 360

Query: 361 WTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGR 420
           WTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGR
Sbjct: 361 WTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGR 420

Query: 421 QGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHLPLL 480
           QGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHLPLL
Sbjct: 421 QGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHLPLL 480

Query: 481 PPSNSYWAGHTPEQH 495
           PPSNSYWAGHTPEQH
Sbjct: 481 PPSNSYWAGHTPEQH 495


>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score =  907 bits (2344), Expect = 0.0
 Identities = 476/558 (85%), Positives = 482/558 (86%), Gaps = 63/558 (11%)

Query: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60
           MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA
Sbjct: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60

Query: 61  LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPTWN 120
           LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPTWN
Sbjct: 61  LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPTWN 120

Query: 121 LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF 180
           LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF
Sbjct: 121 LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF 180

Query: 181 PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ 240
           PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ
Sbjct: 181 PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ 240

Query: 241 DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS 300
           DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS
Sbjct: 241 DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS 300

Query: 301 SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRAN--- 357
           SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRA+   
Sbjct: 301 SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASFRR 360

Query: 358 ------------------LPGWTVLFLSVLG--------LLASRAVSALSSL-------- 383
                             L    ++FL +          LL    V+ L+SL        
Sbjct: 361 SLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQY 420

Query: 384 --------------------------FAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTL 417
                                     FAAEVFPTVIRGAGLGLVLGAGFLGQAAG LDTL
Sbjct: 421 LPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTL 480

Query: 418 HGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHL 477
           HGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHL
Sbjct: 481 HGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHL 540

Query: 478 PLLPPSNSYWAGHTPEQH 495
           PLLPPSNSYWAGHTPEQH
Sbjct: 541 PLLPPSNSYWAGHTPEQH 558


>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
           [Homo sapiens]
          Length = 560

 Score =  898 bits (2321), Expect = 0.0
 Identities = 474/560 (84%), Positives = 480/560 (85%), Gaps = 65/560 (11%)

Query: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60
           MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA
Sbjct: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60

Query: 61  LRALRGPALLDAAIPRLGPTRA--PAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT 118
           LRALRGPALLDAAIPRLGPTRA  P   LGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT
Sbjct: 61  LRALRGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT 120

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA
Sbjct: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
           SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL
Sbjct: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 240

Query: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 298
           VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG
Sbjct: 241 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 300

Query: 299 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRAN- 357
           DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRA+ 
Sbjct: 301 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF 360

Query: 358 --------------------LPGWTVLFLSVLG--------LLASRAVSALSSL------ 383
                               L    ++FL +          LL    V+ L+SL      
Sbjct: 361 RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA 420

Query: 384 ----------------------------FAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLD 415
                                       FAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLD
Sbjct: 421 QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLD 480

Query: 416 TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD 475
           TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD
Sbjct: 481 TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD 540

Query: 476 HLPLLPPSNSYWAGHTPEQH 495
           HLPLLPPSNSYWAGHTPEQH
Sbjct: 541 HLPLLPPSNSYWAGHTPEQH 560


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  194 bits (494), Expect = 1e-49
 Identities = 149/432 (34%), Positives = 204/432 (47%), Gaps = 70/432 (16%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           W+LVC  GW+V LEQ+  +LG+  G + LG   DRFGRR + + +L L    G   A A 
Sbjct: 90  WDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAG 149

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
           S   ++ LR L G  LAG  L +YL RLELCDP  RL  ++   L  V G  L  GLA +
Sbjct: 150 SSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALV 209

Query: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 298
            +DWR LQ +      +L LF+G+P LF ES  WL+   Q+  A+ +L   AE +   P 
Sbjct: 210 SKDWRFLQRM-ITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERN--RPH 266

Query: 299 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSL--------- 349
              L E +     +L   +   P     S   LL  R  W+N LILGF++          
Sbjct: 267 GQMLGEEAQEALQDLEN-TCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCY 325

Query: 350 --VGGG-----------IRANLPGWTVLFLSV-------------------------LGL 371
             VGGG           + +       +FL V                         LGL
Sbjct: 326 QPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGL 385

Query: 372 --------LASRAVSALSSLFAAEVFPTV---------IRGAGLGLVLGAGFLGQAAGLL 414
                   + + +V  L S  AA +  T+         +RG GLGL++  G LG  +G  
Sbjct: 386 WDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPA 445

Query: 415 DTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRP-- 472
             LH   G FLQ VV A+ A+L +L ++LLPE++ + LP+ L+D +  RR  LLR  P  
Sbjct: 446 QRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPT 505

Query: 473 RQDHLPLLPPSN 484
           R DH+PLL   N
Sbjct: 506 RCDHVPLLATPN 517


>gi|21361834 solute carrier family 22, member 17 isoform a [Homo
           sapiens]
          Length = 538

 Score =  175 bits (443), Expect = 1e-43
 Identities = 149/451 (33%), Positives = 201/451 (44%), Gaps = 90/451 (19%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           W+LVC  GW+V LEQ+  +LG+  G + LG   DRFGRR + + +L L    G   A A 
Sbjct: 90  WDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAG 149

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
           S   ++ LR L G  LAG  L +YL RLELCDP  RL  ++   L  V G  L  GLA +
Sbjct: 150 SSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALV 209

Query: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 298
            +DWR LQ +      +L LF+G+P LF ES  WL+   Q+  A+ +L   AE +   P 
Sbjct: 210 SKDWRFLQRM-ITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERN--RPH 266

Query: 299 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLV-------- 350
              L E +     +L   +   P     S   LL  R  W+N LILGF++ +        
Sbjct: 267 GQMLGEEAQEALQDLEN-TCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCY 325

Query: 351 ----GGGIRANL-------PGWTVLFLSVLG-----------LLASRAVSALSSLFAA-- 386
               GGG  ++         G   L    LG           LL S  ++ ++SL     
Sbjct: 326 QPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGL 385

Query: 387 -----EVFPTVIRGAG------------LGLVLGAGFLGQAAGLLDT------------- 416
                 +FPTV    G               VLG  F  QAA +L T             
Sbjct: 386 WDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGL-FSSQAAAILSTLLAAEVIPTTVRG 444

Query: 417 ---------------------LHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQS 455
                                LH   G FLQ VV A+ A+L +L ++LLPE++ + LP+ 
Sbjct: 445 RGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEV 504

Query: 456 LQDADRLRRSPLLRGRP--RQDHLPLLPPSN 484
           L+D +  RR  LLR  P  R DH+PLL   N
Sbjct: 505 LRDGELCRRPSLLRQPPPTRCDHVPLLATPN 535


>gi|170650643 solute carrier family 22, member 23 isoform a [Homo
           sapiens]
          Length = 686

 Score =  153 bits (386), Expect = 4e-37
 Identities = 143/486 (29%), Positives = 217/486 (44%), Gaps = 57/486 (11%)

Query: 1   MEQEARVLRAAGGFGRA-RRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRP--DPTLL 57
           ++ +  VL   GG G   ++ L   +W+P + +G    S+  L  QP   CR     T L
Sbjct: 78  LDYDGSVLPFLGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTEL 137

Query: 58  PPALRALRGPALLD-AAIPRLGPTRAPAEALGVLSPSYLA------PLTRAPRPSSWAS- 109
                  RG  + +  ++P      AP EA G  S S  A      PL   P     AS 
Sbjct: 138 AGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGGDTPPLPSPPDKGDNASN 197

Query: 110 CS------GAAAG------PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRR 157
           C       G  AG        W+LVC + WKV + + S L+G + G +I G   D  GRR
Sbjct: 198 CDCRAWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRR 257

Query: 158 AVFVASLVLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAF 217
            V + S++     G + AL+ +      LR   G  LAG +L LY  R+ELC P  R   
Sbjct: 258 PVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMI 317

Query: 218 SMGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATG 277
           +M A   ++ G  L+PGLAAL +DW++LQ L      L+LL+W   ++FPES  WL+AT 
Sbjct: 318 TMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYW---SIFPESLRWLMATQ 374

Query: 278 QVARARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVT 337
           Q   A++++  F + + + P     E +      EL    +R  +P+    + ++ TR  
Sbjct: 375 QFESAKRLILHFTQKNRMNP-----EGDIKGVIPELEKELSR--RPKKVCIVKVVGTRNL 427

Query: 338 WRNGLILGFSSLVGGGIR----ANLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVI 393
           W+N ++L  +SL G GI      ++ G  V    +    A    +A  +L +      V+
Sbjct: 428 WKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVV 487

Query: 394 RGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVL-LLPESRSRGL 452
           R           FLG+  GLL         F+     ASL  L LL ++    +    G+
Sbjct: 488 R-----------FLGRRGGLL--------LFMILTALASLLQLGLLNLIGKYSQHPDSGM 528

Query: 453 PQSLQD 458
             S++D
Sbjct: 529 SDSVKD 534



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 50/134 (37%), Positives = 79/134 (58%), Gaps = 7/134 (5%)

Query: 342 LILGFSSLVG-------GGIRANLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIR 394
           L LG  +L+G        G+  ++     +  S++G+ AS AV +LS  F AE+ PTVIR
Sbjct: 509 LQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIR 568

Query: 395 GAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQ 454
             GLGLVL +   G     +  LH ++G+FL  ++FA   ++ ++C+LLLPESR + LP+
Sbjct: 569 CGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPE 628

Query: 455 SLQDADRLRRSPLL 468
           ++ + +   R PLL
Sbjct: 629 NISNGEHYTRQPLL 642


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  126 bits (317), Expect = 4e-29
 Identities = 152/547 (27%), Positives = 224/547 (40%), Gaps = 97/547 (17%)

Query: 12  GGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCR-PDPTLLPPALRALRGPALL 70
           G F R    L SAS +P    GL   S   L A P   CR PD   L  A R    P  L
Sbjct: 15  GPFQRLIFFLLSASIIPNGFTGL---SSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRL 71

Query: 71  --DAAIP------RLGPTRAPAEALGVLSPSYLAPLTRAPRPS---SWASCSGAAAGPT- 118
                +P      RL  T A   ALG L P     L +  + S    W            
Sbjct: 72  RDGREVPHSCRRYRLA-TIANFSALG-LEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIV 129

Query: 119 --WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEAL 176
             WNLVC D WK PL      +G LLG  I G   DRFGR+ V   ++ + TG    +  
Sbjct: 130 TEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIF 189

Query: 177 AASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFS-MGAGLFSVVGTLLLPGL 235
           + +F   +VL +L G       +A ++   E+     R+ FS +G  +F   G ++LP  
Sbjct: 190 SKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLF 249

Query: 236 AALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGV 295
           A  ++DWR+L     +   L +  W F    PESP WL++ G+   A  I+ + A+A+G+
Sbjct: 250 AYFIRDWRMLLVALTMPGVLCVALWWF---IPESPRWLISQGRFEEAEVIIRKAAKANGI 306

Query: 296 GPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRT---RVTWRNGLILGFSSLVG- 351
                 +  +++   +EL  LS++  Q   H+ L LLRT   R+     ++L  +  VG 
Sbjct: 307 ------VVPSTIFDPSELQDLSSKKQQS--HNILDLLRTWNIRMVTIMSIMLWMTISVGY 358

Query: 352 -----------GGIRAN--------LPGW-----------------TVLFL--------- 366
                      G I  N        +P +                 T LFL         
Sbjct: 359 FGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQ 418

Query: 367 ----------SVLGLLASRAVSALSSL---FAAEVFPTVIRGAGLGLVLGAGFLGQAAGL 413
                     +VL ++    V+A  S+   + AE++PTV+R  G+G+   A  LG     
Sbjct: 419 LVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSP 478

Query: 414 LDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPR 473
                G    FL  ++  SL +L  +  L LPES    LP ++   D++ R   ++ R  
Sbjct: 479 YFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI---DQMLRVKGMKHRKT 535

Query: 474 QDHLPLL 480
             H  +L
Sbjct: 536 PSHTRML 542


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  120 bits (302), Expect = 2e-27
 Identities = 136/535 (25%), Positives = 214/535 (40%), Gaps = 82/535 (15%)

Query: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRAL 64
           + +L   G  G  + L  +   +P + +      +    A P  HCRP          A 
Sbjct: 4   SEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHN-------AS 56

Query: 65  RGPALLDAAIPRLGPTRAPAEALGVLSP---SYLAPLTRAPRP--SSWASCSGAAAGPT- 118
            GP +L      +GP   P   L  + P   S      RA  P    W   S   +  T 
Sbjct: 57  TGPWVLP-----MGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTE 111

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           W+LVC       + Q   + G L+G ++LG   DRFGRR +   S +L    G+  A + 
Sbjct: 112 WDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSP 171

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
           +FP  +V R L G  ++G  L+  +  +E      R   S   G     G  +LPGLA  
Sbjct: 172 TFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYA 231

Query: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 298
           +  WR LQ     +S    +F+      PES  WL+ +G+ ++A KIL R A  +G    
Sbjct: 232 IPQWRWLQ---LTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEE 288

Query: 299 DS--SLEENSLATATELTMLSAR-SPQPRYHSPLGLLRT---RVTW-------------- 338
               SLEE  L    E+++  A+ +    +  P+    T    + W              
Sbjct: 289 GERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGV 348

Query: 339 -RNGLILGFSSLVGGGIRANLPGWTVLFLSVLG---------LLASRAVSALS------- 381
              G+ L    ++ GG+       T+L LS LG         LLA  A+ AL+       
Sbjct: 349 EEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQ 408

Query: 382 ---------------------SLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGR 420
                                 L+ +E++PTVIR  G+G+      +G     L  + G 
Sbjct: 409 TVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGE 468

Query: 421 QGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD 475
              F+  +++   A+L     L LPE+ ++ LP++++D   L    L   +P+Q+
Sbjct: 469 VQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIED---LENWSLRAKKPKQE 520


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  113 bits (283), Expect = 3e-25
 Identities = 114/415 (27%), Positives = 164/415 (39%), Gaps = 75/415 (18%)

Query: 111 SGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGL 170
           S  A    W+LVC               G L+G V  G   DRFGRR + + + V T  L
Sbjct: 126 STIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVL 185

Query: 171 GASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTL 230
           G + A + S+    + R L G  LAG  + +    LE  D  HR    + +  F   G +
Sbjct: 186 GLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVM 245

Query: 231 LLPGLAALVQDWR--LLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWR 288
           LL  +  L++DWR  LL        G+L L+W      PES  WLL  G V  A + L  
Sbjct: 246 LLALVGYLIRDWRWLLLAVTLPCAPGILSLWW-----VPESARWLLTQGHVKEAHRYLLH 300

Query: 289 FAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTR----------VTW 338
            A  +G    + S  + +      ++ ++A     R  S L L RT           V W
Sbjct: 301 CARLNGRPVCEDSFSQEA------VSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVW 354

Query: 339 --RNGLILGFSSLVGG-GIR----------ANLPGWTVLFLSV----------------- 368
              N    G S  V G G+             LP   +++LSV                 
Sbjct: 355 FGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTA 414

Query: 369 ----------------------LGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGF 406
                                 +G   S A    + LF +E++PTV+R  G+GL    G 
Sbjct: 415 LAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGR 474

Query: 407 LGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADR 461
           LG +   L  L       L ++ +  +A+LA    LLLPE+R   LP+++QD +R
Sbjct: 475 LGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER 529


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  113 bits (282), Expect = 5e-25
 Identities = 112/407 (27%), Positives = 162/407 (39%), Gaps = 75/407 (18%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           W+LVC               G L+G V  G   DRFGRR + + + V T  LG + A + 
Sbjct: 132 WDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASV 191

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
           S+    + R L G  LAG  + +    LE  D  HR    + +  F   G +LL  +  L
Sbjct: 192 SYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYL 251

Query: 239 VQDWR--LLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVG 296
           ++DWR  LL        G+L L+W      PES  WLL  G V  A + L   A  +G  
Sbjct: 252 IRDWRWLLLAVTLPCAPGILSLWW-----VPESARWLLTQGHVKEAHRYLLHCARLNGRP 306

Query: 297 PGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTR----------VTW--RNGLIL 344
             + S  + +      ++ ++A     R  S L L RT           V W   N    
Sbjct: 307 VCEDSFSQEA------VSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYY 360

Query: 345 GFSSLVGG-GIR----------ANLPGWTVLFLSV------------------------- 368
           G S  V G G+             LP   +++LSV                         
Sbjct: 361 GLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLL 420

Query: 369 --------------LGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLL 414
                         +G   S A    + LF +E++PTV+R  G+GL    G LG +   L
Sbjct: 421 VSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPL 480

Query: 415 DTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADR 461
             L       L ++ +  +A+LA    LLLPE+R   LP+++QD +R
Sbjct: 481 AALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER 527


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  111 bits (277), Expect = 2e-24
 Identities = 106/402 (26%), Positives = 167/402 (41%), Gaps = 64/402 (15%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           WNLVC D WKVPL      +G LLG  + G   DRFGR+ V  A++ + TG    +  + 
Sbjct: 132 WNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSI 191

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFS-MGAGLFSVVGTLLLPGLAA 237
           S+    VL ++ G       +  ++   E+     R+ FS +G   F  VG +LLP  A 
Sbjct: 192 SWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAY 251

Query: 238 LVQDWRLLQGLGALMSGLLLL-FWGFPALFPESPCWLLATGQVARARKILWRFAEASGVG 296
            ++DWR+L  L   + G+L +  W F    PESP WL++  +   A  I+ + A+ + + 
Sbjct: 252 FIRDWRMLL-LALTVPGVLCVPLWWF---IPESPRWLISQRRFREAEDIIQKAAKMNNIA 307

Query: 297 PGD---SSLEE-----------------NSLATATELTM--------------------- 315
                  S+EE                  ++A  T +++                     
Sbjct: 308 VPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLH 367

Query: 316 --------LSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIR--ANLPGWTVLF 365
                   LSA    P Y +   LLR   T     I+      GGG+     L      F
Sbjct: 368 GDAYLNCFLSALIEIPAYITAWLLLR---TLPRRYIIAAVLFWGGGVLLFIQLVPVDYYF 424

Query: 366 LSV----LGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQ 421
           LS+    LG     +  ++  +F AE++PT++R   +G+   A  +G          G  
Sbjct: 425 LSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAY 484

Query: 422 GFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLR 463
              L  +V  SL VL  +  L  PES    LP++L+   +++
Sbjct: 485 NRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVK 526


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  107 bits (267), Expect = 2e-23
 Identities = 119/472 (25%), Positives = 189/472 (40%), Gaps = 86/472 (18%)

Query: 58  PPALRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGP 117
           PP  R      LL+AA      + +   AL    P    P   AP          A A  
Sbjct: 83  PPERRGRCQRYLLEAA----NDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYAQAHS 138

Query: 118 T----WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGAS 173
           T    ++LVC + W + L Q    LG+L G   LG   DR+GR  +++ S +     G  
Sbjct: 139 TIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVV 198

Query: 174 EALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLP 233
            A A +FP  ++ R L G    G  +  Y+   E+     R    +   +F  +G ++LP
Sbjct: 199 VAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILP 258

Query: 234 GLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS 293
           G+A  + +W+ +Q    L S L LL++    + PESP WL+   +  +A +IL R A+ +
Sbjct: 259 GIAYFIPNWQGIQLAITLPSFLFLLYYW---VVPESPRWLITRKKGDKALQILRRIAKCN 315

Query: 294 GVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFS------ 347
           G       L  N     +E+T+       P +   L L+RT    +  LIL F+      
Sbjct: 316 G-----KYLSSN----YSEITVTDEEVSNPSF---LDLVRTPQMRKCTLILMFAWFTSAV 363

Query: 348 ---------SLVGGGIR--------ANLPGWTVLFLSV------LGLLASRAVSALSSLF 384
                     ++GG +           LPG  ++ L++      L   AS  V+ ++ L 
Sbjct: 364 VYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLV 423

Query: 385 AA---------------------------------EVFPTVIRGAGLGLVLG-AGFLGQA 410
            A                                 E++PT +R  G+ L  G   F G  
Sbjct: 424 TAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGII 483

Query: 411 AGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRL 462
           A  L          L  ++F  LA +    V+LLPE++   LP+++ D ++L
Sbjct: 484 APFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKL 535


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  105 bits (262), Expect = 9e-23
 Identities = 99/409 (24%), Positives = 179/409 (43%), Gaps = 62/409 (15%)

Query: 112 GAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLG 171
           G++    +NLVC + W + L Q S  +G+ +G + +G   DRFGR+   + ++++    G
Sbjct: 132 GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAG 191

Query: 172 ASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLL 231
              A++ ++  +L+ RL+ G       L  Y+   E     +R    +   +   VG L+
Sbjct: 192 VLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLV 251

Query: 232 LPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAE 291
           L G+A  +  WR LQ   AL +   LL++      PESP WL++  + A A +I+   A+
Sbjct: 252 LAGVAYALPHWRWLQFTVALPNFFFLLYYW---CIPESPRWLISQNKNAEAMRIIKHIAK 308

Query: 292 ASGVGPGDS----SLEENSLATATELTMLSARSPQPRYHSPL-------------GLLRT 334
            +G     S     LEE +        +   R+PQ R H+ +             GL+  
Sbjct: 309 KNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMH 368

Query: 335 RVTWRNGLILGF-----------------------------SSLVGGG---IRANLPG-- 360
                + + L F                             S++V G        +PG  
Sbjct: 369 MGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDL 428

Query: 361 -WTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLD--TL 417
            W  + +S LG +       +  L  AE++PT IR  G+ +      +G   G++    +
Sbjct: 429 QWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIG---GIITPFLV 485

Query: 418 HGRQGFFLQ--QVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRR 464
           +     +L+   +VF  L ++A   VLLLPE++ + LP+++++A+ ++R
Sbjct: 486 YRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQR 534


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  102 bits (253), Expect = 1e-21
 Identities = 131/532 (24%), Positives = 214/532 (40%), Gaps = 87/532 (16%)

Query: 21  LASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRGPAL-LDAAIPRLGP 79
           L SA++ P I +G+V      L   P  HC+  P +   + R    PA  L+  +P LGP
Sbjct: 27  LLSAAFAP-ICVGIVF-----LGFTPDHHCQ-SPGVAELSQRCGWSPAEELNYTVPGLGP 79

Query: 80  TRAP-------------AEALGVLSPSYLAPLTRAPRP-----SSWA-SCSGAAAGPTWN 120
                              AL  + P       R+  P       W     G++    +N
Sbjct: 80  AGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTPGSSIVTEFN 139

Query: 121 LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF 180
           LVC D WK+ L Q     G+L G + +G   DRFGR+   + ++++    G   A + ++
Sbjct: 140 LVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNY 199

Query: 181 PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ 240
            ++L+ RLL G    G  +A Y    E      R   ++   +   VG + L GLA  + 
Sbjct: 200 MSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALP 259

Query: 241 DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASG-VGPGD 299
            WR LQ   +L + L LL++      PESP WLL+  +   A KI+   A+ +G + P D
Sbjct: 260 HWRWLQLAVSLPTFLFLLYYW---CVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPAD 316

Query: 300 ---SSLEENSLATATELTMLSARSPQPRYHS--PLGLLRTRVTWRNGLILGFSSLVGG-- 352
               SLEE+     +       R+P+ R  +   + L  T      GLIL   +  G   
Sbjct: 317 LKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLY 376

Query: 353 -----GIRANLPG---------------------------------------WTVLFLSV 368
                     +PG                                       W  + +  
Sbjct: 377 LDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMC 436

Query: 369 LGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQGF-FLQQ 427
           +G +       +  L  AE++PT +R  G+ +      +G           R+ +  L  
Sbjct: 437 VGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPL 496

Query: 428 VVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHLPL 479
           ++FA L +LA    LLLPE++   LP++++DA+ L R    + +P+++ + L
Sbjct: 497 ILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGR----KAKPKENTIYL 544


>gi|48526516 solute carrier family 22, member 23 isoform b [Homo
           sapiens]
          Length = 405

 Score =  101 bits (251), Expect = 2e-21
 Identities = 84/278 (30%), Positives = 131/278 (47%), Gaps = 34/278 (12%)

Query: 186 LRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQDWRLL 245
           LR   G  LAG +L LY  R+ELC P  R   +M A   ++ G  L+PGLAAL +DW++L
Sbjct: 5   LRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVL 64

Query: 246 QGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDSSLEEN 305
           Q L      L+LL+W   ++FPES  WL+AT Q   A++++  F + + + P     E +
Sbjct: 65  QALIICPFLLMLLYW---SIFPESLRWLMATQQFESAKRLILHFTQKNRMNP-----EGD 116

Query: 306 SLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIR----ANLPGW 361
                 EL    +R  +P+    + ++ TR  W+N ++L  +SL G GI      ++ G 
Sbjct: 117 IKGVIPELEKELSR--RPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGH 174

Query: 362 TVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQ 421
            V    +    A    +A  +L +      V+R           FLG+  GLL       
Sbjct: 175 EVKVPLLENFYADYYTTASIALVSCLAMCVVVR-----------FLGRRGGLL------- 216

Query: 422 GFFLQQVVFASLAVLALLCVL-LLPESRSRGLPQSLQD 458
             F+     ASL  L LL ++    +    G+  S++D
Sbjct: 217 -LFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKD 253



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 50/134 (37%), Positives = 79/134 (58%), Gaps = 7/134 (5%)

Query: 342 LILGFSSLVG-------GGIRANLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIR 394
           L LG  +L+G        G+  ++     +  S++G+ AS AV +LS  F AE+ PTVIR
Sbjct: 228 LQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIR 287

Query: 395 GAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQ 454
             GLGLVL +   G     +  LH ++G+FL  ++FA   ++ ++C+LLLPESR + LP+
Sbjct: 288 CGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPE 347

Query: 455 SLQDADRLRRSPLL 468
           ++ + +   R PLL
Sbjct: 348 NISNGEHYTRQPLL 361


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 147/544 (27%), Positives = 211/544 (38%), Gaps = 108/544 (19%)

Query: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHC----RPDPTLLPPA 60
           + +L   GG GR + L   A  V  + L      E    A P+  C      + T     
Sbjct: 4   SELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASI 63

Query: 61  LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSY--LAPLTRA---------PRPSSWA- 108
           L +L   ALL  +IP  GP + P +      P +  L P   A         P    W  
Sbjct: 64  LGSLSPEALLAISIPP-GPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVY 122

Query: 109 --SCSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVL 166
             S   +     WNLVC      P+ Q  +L G L+G    G   DRFGRR V   S + 
Sbjct: 123 DRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQ 182

Query: 167 TTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLE--------LCDPPHRLAFS 218
              +G + A A +FP   + R L    +AG ++      +E        L    + L FS
Sbjct: 183 MAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFS 242

Query: 219 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQ 278
            G GL + V        A  V+DW LLQ + ++   L  L+  + A   ES  WLL TG+
Sbjct: 243 FGHGLTAAV--------AYGVRDWTLLQLVVSVPFFLCFLYSWWLA---ESARWLLTTGR 291

Query: 279 VARARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLL------ 332
           +    + LWR A  +G G    +L    L +A    +   + P     + LG L      
Sbjct: 292 LDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPP-----ASLGTLLRMPGL 346

Query: 333 --RTRVTWRNGLILGFS--------SLVGGGI--------RANLPG--WTVLFLSVLGLL 372
             RT ++       GF+          +G  I          ++P     +L LS LG  
Sbjct: 347 RFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRR 406

Query: 373 ASRAVSALSS---LFAAEVFP-------TVIRGAGLGLVLGAGF---------------- 406
            + A S L +   + A  + P       + +   GLG V GA F                
Sbjct: 407 PTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGV-GAAFTCITIYSSELFPTVLR 465

Query: 407 -----LGQAA-------GLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQ 454
                LGQ A       G L  L G  G +L  +V+ ++ VL+ L  LLLPE++S  LP 
Sbjct: 466 MTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPD 525

Query: 455 SLQD 458
           ++QD
Sbjct: 526 TIQD 529


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 127/519 (24%), Positives = 197/519 (37%), Gaps = 72/519 (13%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L+  GG GR +++  +   +P +++    + +    A P  HCRP      PA   L  
Sbjct: 6   LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRP------PADANLSK 59

Query: 67  PALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAG---------- 116
              L+  +PR      P   L   SP +  P       +   +      G          
Sbjct: 60  NGGLEVWLPR-DRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118

Query: 117 ---PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGAS 173
                W+LVC       L Q  +++G LLG ++ G   DR GRR V + + + T   G  
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 174 EALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLP 233
            A A +FP     RLL G  LAG  L      +E      R       G    +G  LL 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 234 GLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS 293
           G+A  V  WR LQ    L+S     F+ +   F ES  W  ++G++    + L R A  +
Sbjct: 239 GVAYAVPHWRHLQ---LLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARIN 295

Query: 294 GVGPGDSSLEENSLATA--TELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGF----S 347
           G     + L    L  +   ELTM   ++      S + LLR        L L      +
Sbjct: 296 GKREEGAKLSMEVLRASLQKELTMGKGQA------SAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 348 SLVGGGIRANLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTV-IRGAGLGLVLGAGF 406
           S    G+  +L G+ V    +  +    AV   + L    V  ++  R A +  +L AG 
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFG--AVDLPAKLVGFLVINSLGRRPAQMAALLLAGI 407

Query: 407 LGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCV-----------------------LL 443
                G++           Q +V  SLAVL   C+                       +L
Sbjct: 408 CILLNGVIPQ--------DQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRAVTVL 459

Query: 444 LPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHLPLLPP 482
           LPE+  + LP ++QD +  +     + R +Q+H   + P
Sbjct: 460 LPETLGQPLPDTVQDLESRKGK---QTRQQQEHQKYMVP 495


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 86/324 (26%), Positives = 127/324 (39%), Gaps = 25/324 (7%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L+  GG GR +++  +   +P +++    + +    A P  HCRP      PA   L  
Sbjct: 6   LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRP------PADANLSK 59

Query: 67  PALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAG---------- 116
              L+  +PR      P   L   SP +  P       +   +      G          
Sbjct: 60  NGGLEVWLPR-DRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118

Query: 117 ---PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGAS 173
                W+LVC       L Q  +++G LLG ++ G   DR GRR V + + + T   G  
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 174 EALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLP 233
            A A +FP     RLL G  LAG  L      +E      R       G    +G  LL 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 234 GLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS 293
           G+A  V  WR LQ    L+S     F+ +   F ES  W  ++G++    + L R A  +
Sbjct: 239 GVAYAVPHWRHLQ---LLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARIN 295

Query: 294 GVGPGDSSLEENSLATA--TELTM 315
           G     + L    L  +   ELTM
Sbjct: 296 GKREEGAKLSMEVLRASLQKELTM 319


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 86/324 (26%), Positives = 127/324 (39%), Gaps = 25/324 (7%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L+  GG GR +++  +   +P +++    + +    A P  HCRP      PA   L  
Sbjct: 6   LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRP------PADANLSK 59

Query: 67  PALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAG---------- 116
              L+  +PR      P   L   SP +  P       +   +      G          
Sbjct: 60  NGGLEVWLPR-DRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118

Query: 117 ---PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGAS 173
                W+LVC       L Q  +++G LLG ++ G   DR GRR V + + + T   G  
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 174 EALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLP 233
            A A +FP     RLL G  LAG  L      +E      R       G    +G  LL 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 234 GLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS 293
           G+A  V  WR LQ    L+S     F+ +   F ES  W  ++G++    + L R A  +
Sbjct: 239 GVAYAVPHWRHLQ---LLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARIN 295

Query: 294 GVGPGDSSLEENSLATA--TELTM 315
           G     + L    L  +   ELTM
Sbjct: 296 GKREEGAKLSMEVLRASLQKELTM 319



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 29/117 (24%), Positives = 55/117 (47%), Gaps = 3/117 (2%)

Query: 366 LSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFL 425
           L+VLG     A      L+  E++PT+IR  G+G+      +G     L ++       +
Sbjct: 426 LAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSM 485

Query: 426 QQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHLPLLPP 482
              ++ ++ V A    +LLPE+  + LP ++QD +  +     + R +Q+H   + P
Sbjct: 486 PLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGK---QTRQQQEHQKYMVP 539


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 86/324 (26%), Positives = 127/324 (39%), Gaps = 25/324 (7%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L+  GG GR +++  +   +P +++    + +    A P  HCRP      PA   L  
Sbjct: 6   LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRP------PADANLSK 59

Query: 67  PALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAG---------- 116
              L+  +PR      P   L   SP +  P       +   +      G          
Sbjct: 60  NGGLEVWLPR-DRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118

Query: 117 ---PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGAS 173
                W+LVC       L Q  +++G LLG ++ G   DR GRR V + + + T   G  
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 174 EALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLP 233
            A A +FP     RLL G  LAG  L      +E      R       G    +G  LL 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 234 GLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS 293
           G+A  V  WR LQ    L+S     F+ +   F ES  W  ++G++    + L R A  +
Sbjct: 239 GVAYAVPHWRHLQ---LLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARIN 295

Query: 294 GVGPGDSSLEENSLATA--TELTM 315
           G     + L    L  +   ELTM
Sbjct: 296 GKREEGAKLSMEVLRASLQKELTM 319



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 25/95 (26%), Positives = 46/95 (48%)

Query: 366 LSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFL 425
           L+VLG     A      L+  E++PT+IR  G+G+      +G     L ++       +
Sbjct: 426 LAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSM 485

Query: 426 QQVVFASLAVLALLCVLLLPESRSRGLPQSLQDAD 460
              ++ ++ V A    +LLPE+  + LP ++QD +
Sbjct: 486 PLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLE 520


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 89/309 (28%), Positives = 136/309 (44%), Gaps = 34/309 (11%)

Query: 21  LASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRGPAL-LDAAIPRLGP 79
           L SA++ P I +G+V      L   P  HC+  P +   + R    PA  L+  +P LGP
Sbjct: 27  LLSAAFAP-ICVGIVF-----LGFTPDHHCQ-SPGVAELSQRCGWSPAEELNYTVPGLGP 79

Query: 80  TRAP-------------AEALGVLSPSYLAPLTRAPRP-----SSWA-SCSGAAAGPTWN 120
                              AL  + P       R+  P       W     G++    +N
Sbjct: 80  AGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTPGSSIVTEFN 139

Query: 121 LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF 180
           LVC D WK+ L Q     G+L G + +G   DRFGR+   + ++++    G   A + ++
Sbjct: 140 LVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNY 199

Query: 181 PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ 240
            ++L+ RLL G    G  +A Y    E      R   ++   +   VG + L GLA  + 
Sbjct: 200 MSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALP 259

Query: 241 DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASG-VGPGD 299
            WR LQ   +L + L LL++      PESP WLL+  +   A KI+   A+ +G + P D
Sbjct: 260 HWRWLQLAVSLPTFLFLLYYW---CVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPAD 316

Query: 300 ---SSLEEN 305
               SLEE+
Sbjct: 317 LKMLSLEED 325


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 127/535 (23%), Positives = 202/535 (37%), Gaps = 89/535 (16%)

Query: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRAL 64
           +++L  AGG G  + L      +PC+++   +  E    A P   C         A+   
Sbjct: 4   SKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTN 63

Query: 65  RGP-ALLDAAIPRLGPTRAPAEALGVLSPSY--LAPLTRA---------PRPSSWA---S 109
             P ALL  +IP  GP + P +      P +  L P   A         P    W    S
Sbjct: 64  MTPKALLTISIPP-GPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRS 122

Query: 110 CSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTG 169
              +     W+LVC      PL Q   + G L+G  I G    RFGR+ +     +    
Sbjct: 123 VFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAV 182

Query: 170 LGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGT 229
            G S   A +F     LR +    +AG  L+     +E      R       G     G 
Sbjct: 183 AGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQ 242

Query: 230 LLLPGLAALVQDWRLLQGLGAL-MSGLLLLFWGFPALFPESPCWLLATGQVARARKILWR 288
             L GLA  ++DWR LQ   ++    + L+ W      PES  WL+  G+  +A + L +
Sbjct: 243 AALGGLAFALRDWRTLQLAASVPFFAISLISW----WLPESARWLIIKGKPDQALQELRK 298

Query: 289 FAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRV-TWRN--GLILG 345
            A  +G      +L    L ++ +  + SA+ P+    S L L    V  WR+   L++ 
Sbjct: 299 VARINGHKEA-KNLTIEVLMSSVKEEVASAKEPR----SVLDLFCVPVLRWRSCAMLVVN 353

Query: 346 FSSLVG----------------------GGIRANLPGWTVLFLSVLG----LLASRAVSA 379
           FS L+                       G +       T L LS LG       S+A++ 
Sbjct: 354 FSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAG 413

Query: 380 LS---------------------------------SLFAAEVFPTVIRGAGLGLVLGAGF 406
           L+                                 +++ AE+FPT +R    G++   G 
Sbjct: 414 LAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGR 473

Query: 407 LGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVL-LLPESRSRGLPQSLQDAD 460
           LG   G L  +  +    L  +++  +++ + L VL  LPE++   LP ++QD +
Sbjct: 474 LGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLE 528


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 106/400 (26%), Positives = 158/400 (39%), Gaps = 69/400 (17%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           +NLVC         Q   + G L+G ++ G  CDR GR+A  +A L+L T +G + A   
Sbjct: 127 FNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVP 186

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLA--------FSMG----AGL--- 223
           SF   + LR      +AG   +      E   P  R          FS+G    AGL   
Sbjct: 187 SFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYG 246

Query: 224 ------FSVVGTLLLPGLAALVQDWRLLQGL------GALMSGLLLLFWGFPA------- 264
                   + GT   PGL      W L +        G +   + L+             
Sbjct: 247 FRNWRLLQITGTA--PGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSP 304

Query: 265 -----LFPE------SPCWLLATGQVARARKILWRFAEASGVGPGDSSLEENSLATATEL 313
                L PE      +   L    Q+ +   I++       +G    SL+         L
Sbjct: 305 ELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYL 364

Query: 314 TML--SARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGG--------IRANLPGWTV 363
           T L   A     R  S   + R    W         +LV GG        I A+LP   V
Sbjct: 365 TQLIFGAVEVPARCSSIFMMQRFGRKWSQ-----LGTLVLGGLMCIIIIFIPADLPV-VV 418

Query: 364 LFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLD---TLHGR 420
             L+V+G +A+ A   +S +++AE+FPT++R  G+GLV   G   +  G+L     L G 
Sbjct: 419 TMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLV---GIFSRIGGILTPLVILLGE 475

Query: 421 QGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDAD 460
               L  +++ SL ++A L   LLPE+  +GL  +LQD +
Sbjct: 476 YHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 83/299 (27%), Positives = 122/299 (40%), Gaps = 17/299 (5%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L A G  GR +    +   +PC +L      +    A P  HCR  P     A     G
Sbjct: 6   LLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCR-GPANHTEASTNDSG 64

Query: 67  PALLDAAIPRLGPTRAPAEALGVLSPSY--LAPLTRAPRPSSWASCSGAAAGPT------ 118
            A L A IP L    AP        P +  L+P +  P  ++     G     +      
Sbjct: 65  -AWLRATIP-LDQLGAPEPCRRFTKPQWALLSPNSSIPGAATEGCKDGWVYNRSVFPSTI 122

Query: 119 ---WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEA 175
              W+LVC       L Q  ++ G L+G  + G+  DR G +   V S +     GA+ A
Sbjct: 123 VMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAATA 182

Query: 176 LAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGL 235
             +SF    V R L G T +G +L      +E      R    +  G    +G L+L G+
Sbjct: 183 YFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILAGV 242

Query: 236 AALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASG 294
           A L++ WR LQ     +S   L+F+ +    PES  WLL  G+   A + L + A  +G
Sbjct: 243 AYLIRPWRCLQ---FAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNG 298



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 31/92 (33%), Positives = 44/92 (47%), Gaps = 2/92 (2%)

Query: 370 GLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVV 429
           G LAS  +     LF  E++PT IR  G+G       LG     L T  G     L  V 
Sbjct: 434 GCLASSFICVY--LFTGELYPTEIRQMGMGFASVHARLGGLTAPLVTTLGEYSTILPPVS 491

Query: 430 FASLAVLALLCVLLLPESRSRGLPQSLQDADR 461
           F + A+LA L V +L E+R+  L +++   +R
Sbjct: 492 FGATAILAGLAVCVLTETRNMPLVETIAAMER 523


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 55/169 (32%), Positives = 76/169 (44%), Gaps = 5/169 (2%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           WNLVC   W   L Q   + G LLG V  G   DR GRR V  A+       G + A A 
Sbjct: 144 WNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAV 203

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
            + T +  R       +G L+  ++  +E      R   S+    F  VGTLL+     L
Sbjct: 204 DYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYL 263

Query: 239 VQDWRLLQG-LGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKIL 286
           V+ W L Q  L  +    +L  W    + PE+P WLL+ G+   A+KI+
Sbjct: 264 VRTWWLYQMILSTVTVPFILCCW----VLPETPFWLLSEGRYEEAQKIV 308



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 23/96 (23%), Positives = 45/96 (46%)

Query: 367 SVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQ 426
           +++G  A  A   L  L+ AE++PT++R   +G       L                F+ 
Sbjct: 447 AMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIP 506

Query: 427 QVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRL 462
           Q+   ++A+L+ +  L LPE+  + L  + ++A +L
Sbjct: 507 QLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKL 542


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 101/409 (24%), Positives = 171/409 (41%), Gaps = 69/409 (16%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           W+LVC       + Q   L G L+G +I G   DRFGRR +    L+         A A 
Sbjct: 135 WDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCLLQLAITDTCAAFAP 194

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHR-LAFSMGAGLFSVVGTLLLPGLAA 237
           +FP   VLR L G +    +    L   E   P  + L   + +G  S +G ++L GLA 
Sbjct: 195 TFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGALS-IGQIILGGLAY 253

Query: 238 LVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGP 297
           + +DW   Q L  + S    +F+       ES  WL+ T ++    K L + A  +G+  
Sbjct: 254 VFRDW---QTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRKVARTNGIKN 310

Query: 298 GD---------SSLEENSLATATELTMLSA-RSPQP----------RYHSPLGLLRTRVT 337
            +         S+++E   A  T+ T+    R+P            R+ + +    T V 
Sbjct: 311 AEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPFYGTMVN 370

Query: 338 WRN-GLILGFSSLVGGGI----------RANLPG---WTVLFLSVLGL------------ 371
            ++ G  +    ++ G +            N  G     +LF+ ++GL            
Sbjct: 371 LQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILANTFVPKEM 430

Query: 372 ------LASRAVSALSSLFAA------EVFPTVIRGAGLGLVLGAGFLGQA-AGLLDTLH 418
                 LA   +   ++ F++      E+ PTV+R    G+ L A  +G A A LL TL 
Sbjct: 431 QTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGAALAPLLMTL- 489

Query: 419 GRQGFF--LQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRS 465
               FF  L  +++    ++  L V LLPE+++  LP +++D +  +++
Sbjct: 490 --TVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKN 536


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 108/422 (25%), Positives = 159/422 (37%), Gaps = 89/422 (21%)

Query: 109 SCSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTT 168
           S S  +    W L+    +KV         G  +G +  G   DRFGR+ V++    L  
Sbjct: 91  SSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDI 150

Query: 169 GLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPH-RLAFSMGAGLFSVV 227
               +   + S+    V R L G    G  L  ++   E     +  LA S+G GLF  V
Sbjct: 151 LFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIG-GLFFAV 209

Query: 228 GTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILW 287
           G      L   ++ WR L  L  L   ++ L   F    PESP WL + G+++ A + L+
Sbjct: 210 GIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLF---IPESPRWLYSQGRLSEAEEALY 266

Query: 288 RFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGF- 346
             A+               L     LT  + RS +    S L L R RV   + LIL F 
Sbjct: 267 LIAK-----------RNRKLKCTFSLTHPANRSCR-ETGSFLDLFRYRVLLGHTLILMFI 314

Query: 347 ---SSLV-----------GGGIRANL--------PGW----------------------- 361
               SLV           GG I ANL        P +                       
Sbjct: 315 WFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLC 374

Query: 362 -------TVLFL-----------------SVLGLLASRAVSALSSLFAAEVFPTVIRGAG 397
                   V+FL                 S+LG L   A   +  ++ +E++PTVIR  G
Sbjct: 375 LGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVG 434

Query: 398 LGLV-LGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSL 456
           LG   + +   G  A  + +L   Q + L  +VF +  + + L  LLLPE+ +  L ++ 
Sbjct: 435 LGTCSMFSRVGGIIAPFIPSLKYVQ-WSLPFIVFGATGLTSGLLSLLLPETLNSPLLETF 493

Query: 457 QD 458
            D
Sbjct: 494 SD 495


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 71/307 (23%), Positives = 120/307 (39%), Gaps = 47/307 (15%)

Query: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRAL 64
           A +L A G FG  ++ L + +++P I+    + ++  +     P+C              
Sbjct: 53  ANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCN------------- 99

Query: 65  RGPALLDAAIPRLGPTRAPAEALGVLSP-----SYLAPLTRAPRP-----------SSWA 108
                  + I  +GP  + AE L +  P     S+L      P P           +   
Sbjct: 100 ------TSWILAVGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTD 153

Query: 109 SCSGAAAGP---------TWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAV 159
           +C      P          ++LVCG   K    Q+  + G  +G +I     D+ GR   
Sbjct: 154 TCQDGWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPA 213

Query: 160 FVASLVLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSM 219
            + SL+     G   A   SF   L  R     ++ G  ++      E     HR    +
Sbjct: 214 ILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAII 273

Query: 220 GAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQV 279
               F  VG +LL G+A  +  W+LL  +G +   L++ F  +  + PESP WL+  G+V
Sbjct: 274 LGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGI---LVIPFISYIWILPESPRWLMMKGKV 330

Query: 280 ARARKIL 286
             A+++L
Sbjct: 331 KEAKQVL 337



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 35/106 (33%), Positives = 53/106 (50%), Gaps = 3/106 (2%)

Query: 358 LPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTL 417
           L   T+L L +L   +  A   +  L+ AE+ PTV+R  GLGLV  A   G    L  T+
Sbjct: 476 LKSMTILVL-MLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILSL--TI 532

Query: 418 HGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLR 463
             +    L   +   LA++A     LLPE+R + L +SL  + ++R
Sbjct: 533 ISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQIR 578


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 99/406 (24%), Positives = 156/406 (38%), Gaps = 63/406 (15%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           W+LVC       + Q   + G LLG +I G   DR GR+ +     +         A A 
Sbjct: 135 WDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLAISNTCAAFAP 194

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
           +F    +LR L G +    L   ++  LE   P  R    M       VG +LL GLA  
Sbjct: 195 TFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYSVGQMLLGGLAFA 254

Query: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 298
           +QDW +LQ    + + +++LF     +  ES  WL+   Q+    K L R A  +G    
Sbjct: 255 IQDWHILQ--LTVSTPIIVLFLSSWKMV-ESARWLIINNQLDEGLKELRRVAHINGKKNT 311

Query: 299 DSSLEENSLATATELTMLSA-----------RSPQPRYH-SPLGLLRTRVTWR-NGLILG 345
           + +L    L  +T    L A           R+P+ R     L  +R  +T    GLIL 
Sbjct: 312 EETL-TTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAITVPFYGLILN 370

Query: 346 FSSL---------VGGGIRANLPGWTVLFLSVLGLLASRAVSALS-SLF---------AA 386
              L         + G +       ++L L+ +G   S+ +      LF           
Sbjct: 371 LQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFILVNTFLPQEM 430

Query: 387 EVFPTVIRGAGLGLVLGAG-------------FLGQAAGLLDTLHGRQGFFLQQVVFASL 433
           ++   V+   G+G V  A               L      ++ + GR G  L  ++   +
Sbjct: 431 QILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLM 490

Query: 434 A--------------VLALLCVLLLPESRSRGLPQSLQDADRLRRS 465
           A              +LA+  +LLLPE+R   LP ++QD +  + S
Sbjct: 491 AYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENEKDS 536


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 36/93 (38%), Positives = 55/93 (59%)

Query: 366 LSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFL 425
           L+VLGL    A     +++++E+FPTV+R   +GL   A   G   G L  L G  G +L
Sbjct: 216 LAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWL 275

Query: 426 QQVVFASLAVLALLCVLLLPESRSRGLPQSLQD 458
             +V+ ++ VL+ L  LLLPE++S  LP ++QD
Sbjct: 276 PLLVYGTVPVLSGLAALLLPETQSLPLPDTIQD 308


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.140    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,393,415
Number of Sequences: 37866
Number of extensions: 1034958
Number of successful extensions: 3651
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 79
Number of HSP's that attempted gapping in prelim test: 3476
Number of HSP's gapped (non-prelim): 196
length of query: 495
length of database: 18,247,518
effective HSP length: 106
effective length of query: 389
effective length of database: 14,233,722
effective search space: 5536917858
effective search space used: 5536917858
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.