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Search of human proteins with 239756495
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
(1312 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 2589 0.0
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 2566 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 1166 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 1050 0.0
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 1047 0.0
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 1046 0.0
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 987 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 964 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 675 0.0
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 635 0.0
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 610 e-174
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 609 e-174
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 597 e-170
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 597 e-170
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 596 e-170
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 582 e-166
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 568 e-161
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 568 e-161
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 530 e-150
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 518 e-146
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 362 2e-99
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 252 2e-66
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 250 5e-66
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 228 3e-59
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 219 2e-56
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 164 7e-40
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 163 9e-40
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 154 5e-37
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 144 7e-34
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 144 7e-34
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 2589 bits (6711), Expect = 0.0
Identities = 1312/1312 (100%), Positives = 1312/1312 (100%)
Query: 1 MFTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSR 60
MFTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSR
Sbjct: 1 MFTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSR 60
Query: 61 LEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTF 120
LEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTF
Sbjct: 61 LEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTF 120
Query: 121 LLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNM 180
LLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNM
Sbjct: 121 LLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNM 180
Query: 181 YRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLW 240
YRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLW
Sbjct: 181 YRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLW 240
Query: 241 LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLT 300
LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLT
Sbjct: 241 LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLT 300
Query: 301 SSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVF 360
SSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVF
Sbjct: 301 SSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVF 360
Query: 361 AVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVD 420
AVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVD
Sbjct: 361 AVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVD 420
Query: 421 PGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSS 480
PGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSS
Sbjct: 421 PGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSS 480
Query: 481 LLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACAL 540
LLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACAL
Sbjct: 481 LLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACAL 540
Query: 541 QPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHV 600
QPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHV
Sbjct: 541 QPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHV 600
Query: 601 FNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL 660
FNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL
Sbjct: 601 FNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL 660
Query: 661 DQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLD 720
DQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLD
Sbjct: 661 DQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLD 720
Query: 721 DPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLW 780
DPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLW
Sbjct: 721 DPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLW 780
Query: 781 ADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRS 840
ADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRS
Sbjct: 781 ADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRS 840
Query: 841 PISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAI 900
PISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAI
Sbjct: 841 PISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAI 900
Query: 901 LPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNN 960
LPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNN
Sbjct: 901 LPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNN 960
Query: 961 ARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQ 1020
ARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQ
Sbjct: 961 ARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQ 1020
Query: 1021 VTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFQDFG 1080
VTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFQDFG
Sbjct: 1021 VTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFQDFG 1080
Query: 1081 LRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIA 1140
LRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIA
Sbjct: 1081 LRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIA 1140
Query: 1141 HVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQL 1200
HVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQL
Sbjct: 1141 HVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQL 1200
Query: 1201 QYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQC 1260
QYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQC
Sbjct: 1201 QYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQC 1260
Query: 1261 TVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1312
TVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV
Sbjct: 1261 TVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1312
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 2566 bits (6652), Expect = 0.0
Identities = 1301/1311 (99%), Positives = 1304/1311 (99%)
Query: 2 FTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRL 61
F + +NPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRL
Sbjct: 193 FPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRL 252
Query: 62 EKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFL 121
EKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFL
Sbjct: 253 EKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFL 312
Query: 122 LGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMY 181
LGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMY
Sbjct: 313 LGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMY 372
Query: 182 RLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL 241
RLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL
Sbjct: 373 RLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL 432
Query: 242 PLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTS 301
PLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTS
Sbjct: 433 PLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTS 492
Query: 302 SILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFA 361
SILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFA
Sbjct: 493 SILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFA 552
Query: 362 VHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDP 421
VHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDP
Sbjct: 553 VHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDP 612
Query: 422 GAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSL 481
G VDSSSSGSAAGKDCITI SATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSL
Sbjct: 613 GVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSL 672
Query: 482 LSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 541
LSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ
Sbjct: 673 LSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 732
Query: 542 PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF 601
PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF
Sbjct: 733 PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF 792
Query: 602 NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLD 661
NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLD
Sbjct: 793 NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLD 852
Query: 662 QARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDD 721
QARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDD
Sbjct: 853 QARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDD 912
Query: 722 PDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWA 781
PDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWA
Sbjct: 913 PDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWA 972
Query: 782 DDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSP 841
DDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSP
Sbjct: 973 DDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSP 1032
Query: 842 ISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAIL 901
ISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAIL
Sbjct: 1033 ISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAIL 1092
Query: 902 PLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNA 961
PLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNA
Sbjct: 1093 PLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNA 1152
Query: 962 RVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQV 1021
RVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQV
Sbjct: 1153 RVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQV 1212
Query: 1022 TQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFQDFGL 1081
TQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEF+DFGL
Sbjct: 1213 TQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGL 1272
Query: 1082 RYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAH 1141
RYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAH
Sbjct: 1273 RYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAH 1332
Query: 1142 VGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQ 1201
VGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQ
Sbjct: 1333 VGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQ 1392
Query: 1202 YKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCT 1261
YKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCT
Sbjct: 1393 YKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCT 1452
Query: 1262 VLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1312
VLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV
Sbjct: 1453 VLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1503
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 1166 bits (3016), Expect = 0.0
Identities = 615/1340 (45%), Positives = 877/1340 (65%), Gaps = 33/1340 (2%)
Query: 1 MFTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSR 60
+F+ + NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 197 LFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPV 256
Query: 61 LEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLKA 111
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 257 LVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKV 316
Query: 112 IWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACL 171
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++ACL
Sbjct: 317 LYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACL 376
Query: 172 QTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTE 231
QTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR +
Sbjct: 377 QTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD 436
Query: 232 SVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMR 291
Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M+
Sbjct: 437 LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMK 496
Query: 292 QKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVS 351
KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++ +
Sbjct: 497 SKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCT 556
Query: 352 TFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRL 410
FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS RL
Sbjct: 557 PFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRL 616
Query: 411 VTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAV 470
FL EE++P +++ G + IT+++ATF W++ PP L+ I ++P+G L+AV
Sbjct: 617 RIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAV 676
Query: 471 VGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPW 530
VG VG GKSSLLSALL E+ KVEG V+I+G+VAYVPQ+AW+QN S+ EN+ FG +L+ P+
Sbjct: 677 VGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPY 736
Query: 531 LERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLA 590
V++ACAL PD++ P G T IGE+G+NLSGGQKQR+SLARAVY A +YL DDPL+
Sbjct: 737 YRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLS 796
Query: 591 ALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELL 650
A+DAHVG+H+F VIGP G+L+ TRILVTH++ LPQ D IIV++ G I+EMGSYQELL
Sbjct: 797 AVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELL 856
Query: 651 QRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELRRER 698
R GA L +Q + + G G + PG K SAG+ +L+R+
Sbjct: 857 ARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQL 914
Query: 699 SIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAVG 752
S S + +T+E Q + W + D Q G+VK +V+ Y++A+G
Sbjct: 915 SSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIG 971
Query: 753 TPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLF 812
+ ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I +F
Sbjct: 972 LFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVF 1031
Query: 813 ASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKL 872
AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP+ +
Sbjct: 1032 GYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVI 1091
Query: 873 RSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSV 932
+ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S S V
Sbjct: 1092 KMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPV 1151
Query: 933 CSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLV 992
SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN +V
Sbjct: 1152 YSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIV 1211
Query: 993 FAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTP 1052
AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+ T
Sbjct: 1212 LFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETE 1271
Query: 1053 KEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGA 1112
KEAPW++ A WPQ G++EF+++ LRYR +L ++ ++ I+ GEKVGIVGRTGA
Sbjct: 1272 KEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGA 1331
Query: 1113 GKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLL 1172
GKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD
Sbjct: 1332 GKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPF 1391
Query: 1173 QEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQIL 1232
++SDE +W +LE LK V++LP +L ++CA+ GE+LSVGQ+QL+CLARALLRKT+IL
Sbjct: 1392 SQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKIL 1451
Query: 1233 ILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSP 1292
+LDEATAAVD T+ +Q+ + + F CTVL IAHRL ++MD RV+V+DKG++ E G+P
Sbjct: 1452 VLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAP 1511
Query: 1293 AQLLAQKGLFYRLAQESGLV 1312
+ LL Q+GLFY +A+++GLV
Sbjct: 1512 SDLLQQRGLFYSMAKDAGLV 1531
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 1050 bits (2714), Expect = 0.0
Identities = 581/1333 (43%), Positives = 825/1333 (61%), Gaps = 42/1333 (3%)
Query: 10 NPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNR 69
NP PET A F S+ FWW + + GYR PL KDLWSL E+ S+ +V +L + W +
Sbjct: 205 NPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQE 264
Query: 70 SAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRP-LLKAIWQVFHSTFLLGTLSLI 128
RH KA A K SG E E L +P LKA+ F S+FL+ +
Sbjct: 265 KQTARH-KASAAPGKNASG----EDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKL 319
Query: 129 ISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQM 188
I D+ F P+LLS+ + FI +P P+W G+L+A LMFL + +Q+L Q + + V +
Sbjct: 320 IQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGV 379
Query: 189 RLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVV 248
+ R+ I G++YRK L +++ ++AS VG++VNL+SVD QR + +LN LW + I++
Sbjct: 380 KFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIIL 439
Query: 249 CFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK 308
+LWQ LGPS L +A + L+PLN ++ K Q +QM+ KDSR +L S IL K
Sbjct: 440 AIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIK 499
Query: 309 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLV-A 367
+K + WE +FL +V GIR EL LRT+ L + + ++ S FLV L+ V+ V
Sbjct: 500 VLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDP 559
Query: 368 ENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGAVDSS 427
N ++AEKAFV++++ NIL LP I +L QA VS R+ FL EE+DP +V+
Sbjct: 560 NNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERK 619
Query: 428 SSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLG 487
+ ITI S TF W+Q+ PP LH +++ VP+G L+AVVGPVG GKSSL+SALLG
Sbjct: 620 TISPGYA---ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLG 676
Query: 488 ELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSF 547
E+ K+EG V ++G+VAYVPQ+AW+QN ++ ENV FG+ L+P ++ LEACAL D++
Sbjct: 677 EMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEML 736
Query: 548 PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGP 607
P G T IGE+G+NLSGGQ+QR+SLARAVY A ++LLDDPL+A+D+HV +H+F+ VIGP
Sbjct: 737 PGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGP 796
Query: 608 GGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPG 667
G+L G TR+LVTH + LPQ D+IIVLA+G ++EMG Y LLQR G+ L
Sbjct: 797 EGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDE 856
Query: 668 DRG--------------------EGETEPGTSTKDPRGTSAGRRPELRRERSIKS----- 702
D+G E T D + + + R+ S S
Sbjct: 857 DQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEG 916
Query: 703 ----VPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLY 758
VP + SE +V + + G ++ G V+ +V Y +AVG L
Sbjct: 917 QGRPVPRRHLGPSE---KVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLA 973
Query: 759 ALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAV 818
L++ Q A+ WLS W +D +Q +LR G++ LG LQ + + A+
Sbjct: 974 ICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAM 1033
Query: 819 LLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMY 878
GG +A+R+L Q LL + +RSP SFF+ TP G +LN FSK+ VD + + LL
Sbjct: 1034 AAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNS 1093
Query: 879 AFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAE 938
F + +V+ +TPL TV ILPL +LY Q Y +S QL+RLES S S + SH +E
Sbjct: 1094 FFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSE 1153
Query: 939 TFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATC 998
T G++V+RA+ F ++ +VD +QR +P ++++RWL+ VE +GN +V AA
Sbjct: 1154 TVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALF 1213
Query: 999 AVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWR 1058
AV+ ++ L+ GLVG SVS +LQVT L W++R +DLE++IV+VER+++Y+ T EAPW
Sbjct: 1214 AVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWV 1273
Query: 1059 LPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLA 1118
+ WP G++EF+++ +RYRP L L ++ +S +H GEKVGIVGRTGAGKSS+
Sbjct: 1274 VEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMT 1333
Query: 1119 SGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDE 1178
L R+ EAA+G I IDG+ +A +GLH LRS+++IIPQDPILF G+LRMNLD +S+E
Sbjct: 1334 LCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEE 1393
Query: 1179 AIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEAT 1238
IW ALE L V+S P L ++C++ GE+LSVGQ+QL+CLARALLRK++IL+LDEAT
Sbjct: 1394 DIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEAT 1453
Query: 1239 AAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQ 1298
AA+D T+ +QA + + F CTVL IAHRL ++MD RVLV+DKG VAE SPA L+A
Sbjct: 1454 AAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAA 1513
Query: 1299 KGLFYRLAQESGL 1311
+G+FY +A+++GL
Sbjct: 1514 RGIFYGMARDAGL 1526
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 1047 bits (2707), Expect = 0.0
Identities = 579/1340 (43%), Positives = 830/1340 (61%), Gaps = 92/1340 (6%)
Query: 1 MFTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSR 60
+F+ + NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 197 LFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPV 256
Query: 61 LEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLKA 111
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 257 LVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKV 316
Query: 112 IWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACL 171
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++ACL
Sbjct: 317 LYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACL 376
Query: 172 QTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTE 231
QTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR +
Sbjct: 377 QTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD 436
Query: 232 SVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMR 291
Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M+
Sbjct: 437 LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMK 496
Query: 292 QKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVS 351
KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++ +
Sbjct: 497 SKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCT 556
Query: 352 TFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRL 410
FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS RL
Sbjct: 557 PFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRL 616
Query: 411 VTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAV 470
FL EE++P +++ G + IT+++ATF W++ PP L+ I ++P+G L+AV
Sbjct: 617 RIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAV 676
Query: 471 VGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPW 530
VG VG GK S+LL
Sbjct: 677 VGQVGCGK----SSLLS------------------------------------------- 689
Query: 531 LERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLA 590
AL ++D EG H +I +G+NLSGGQKQR+SLARAVY A +YL DDPL+
Sbjct: 690 --------ALLAEMDKV-EG-HVAI--KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLS 737
Query: 591 ALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELL 650
A+DAHVG+H+F VIGP G+L+ TRILVTH++ LPQ D IIV++ G I+EMGSYQELL
Sbjct: 738 AVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELL 797
Query: 651 QRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELRRER 698
R GA L +Q + + G G + PG K SAG+ +L+R+
Sbjct: 798 ARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQL 855
Query: 699 SIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAVG 752
S S + +T+E Q + W + D Q G+VK +V+ Y++A+G
Sbjct: 856 SSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIG 912
Query: 753 TPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLF 812
+ ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I +F
Sbjct: 913 LFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVF 972
Query: 813 ASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKL 872
AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP+ +
Sbjct: 973 GYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVI 1032
Query: 873 RSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSV 932
+ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S S V
Sbjct: 1033 KMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPV 1092
Query: 933 CSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLV 992
SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN +V
Sbjct: 1093 YSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIV 1152
Query: 993 FAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTP 1052
AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+ T
Sbjct: 1153 LFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETE 1212
Query: 1053 KEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGA 1112
KEAPW++ A WPQ G++EF+++ LRYR +L ++ ++ I+ GEKVGIVGRTGA
Sbjct: 1213 KEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGA 1272
Query: 1113 GKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLL 1172
GKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD
Sbjct: 1273 GKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPF 1332
Query: 1173 QEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQIL 1232
++SDE +W +LE LK V++LP +L ++CA+ GE+LSVGQ+QL+CLARALLRKT+IL
Sbjct: 1333 SQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKIL 1392
Query: 1233 ILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSP 1292
+LDEATAAVD T+ +Q+ + + F CTVL IAHRL ++MD RV+V+DKG++ E G+P
Sbjct: 1393 VLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAP 1452
Query: 1293 AQLLAQKGLFYRLAQESGLV 1312
+ LL Q+GLFY +A+++GLV
Sbjct: 1453 SDLLQQRGLFYSMAKDAGLV 1472
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 1046 bits (2704), Expect = 0.0
Identities = 555/1241 (44%), Positives = 795/1241 (64%), Gaps = 33/1241 (2%)
Query: 1 MFTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSR 60
+F+ + NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 197 LFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPV 256
Query: 61 LEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLKA 111
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 257 LVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKV 316
Query: 112 IWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACL 171
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++ACL
Sbjct: 317 LYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACL 376
Query: 172 QTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTE 231
QTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR +
Sbjct: 377 QTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD 436
Query: 232 SVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMR 291
Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M+
Sbjct: 437 LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMK 496
Query: 292 QKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVS 351
KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++ +
Sbjct: 497 SKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCT 556
Query: 352 TFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRL 410
FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS RL
Sbjct: 557 PFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRL 616
Query: 411 VTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAV 470
FL EE++P +++ G + IT+++ATF W++ PP L+ I ++P+G L+AV
Sbjct: 617 RIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAV 676
Query: 471 VGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPW 530
VG VG GKSSLLSALL E+ KVEG V+I+G+VAYVPQ+AW+QN S+ EN+ FG +L+ P+
Sbjct: 677 VGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPY 736
Query: 531 LERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLA 590
V++ACAL PD++ P G T IGE+G+NLSGGQKQR+SLARAVY A +YL DDPL+
Sbjct: 737 YRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLS 796
Query: 591 ALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELL 650
A+DAHVG+H+F VIGP G+L+ TRILVTH++ LPQ D IIV++ G I+EMGSYQELL
Sbjct: 797 AVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELL 856
Query: 651 QRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELRRER 698
R GA L +Q + + G G + PG K SAG+ +L+R+
Sbjct: 857 ARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQL 914
Query: 699 SIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAVG 752
S S + +T+E Q + W + D Q G+VK +V+ Y++A+G
Sbjct: 915 SSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIG 971
Query: 753 TPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLF 812
+ ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I +F
Sbjct: 972 LFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVF 1031
Query: 813 ASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKL 872
AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP+ +
Sbjct: 1032 GYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVI 1091
Query: 873 RSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSV 932
+ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S S V
Sbjct: 1092 KMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPV 1151
Query: 933 CSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLV 992
SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN +V
Sbjct: 1152 YSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIV 1211
Query: 993 FAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTP 1052
AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+ T
Sbjct: 1212 LFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETE 1271
Query: 1053 KEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGA 1112
KEAPW++ A WPQ G++EF+++ LRYR +L ++ ++ I+ GEKVGIVGRTGA
Sbjct: 1272 KEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGA 1331
Query: 1113 GKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLL 1172
GKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD
Sbjct: 1332 GKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPF 1391
Query: 1173 QEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1213
++SDE +W +LE LK V++LP +L ++CA+ GE+L V
Sbjct: 1392 SQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
Score = 82.8 bits (203), Expect = 2e-15
Identities = 61/218 (27%), Positives = 104/218 (47%), Gaps = 16/218 (7%)
Query: 1088 PLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTL 1147
P + G++F I G V +VG+ G GKSSL S LL + EG + I G
Sbjct: 658 PPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG----------- 706
Query: 1148 RSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADR 1207
++ +PQ + SLR N+ + + + ++ L + LP + + ++
Sbjct: 707 --SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEK 764
Query: 1208 GEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLG--SWFAQCTVLL 1264
G +LS GQKQ + LARA+ I + D+ +AVD + + ++G T +L
Sbjct: 765 GVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRIL 824
Query: 1265 IAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLF 1302
+ H + + ++VM G+++E GS +LLA+ G F
Sbjct: 825 VTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 862
Score = 49.3 bits (116), Expect = 2e-05
Identities = 20/36 (55%), Positives = 31/36 (86%)
Query: 1277 RVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1312
RV+V+DKG++ E G+P+ LL Q+GLFY +A+++GLV
Sbjct: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1466
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 987 bits (2552), Expect = 0.0
Identities = 566/1342 (42%), Positives = 810/1342 (60%), Gaps = 93/1342 (6%)
Query: 1 MFTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSR 60
+F+ + NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 197 LFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPV 256
Query: 61 LEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLKA 111
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 257 LVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKV 316
Query: 112 IWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACL 171
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++ACL
Sbjct: 317 LYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACL 376
Query: 172 QTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTE 231
QTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR +
Sbjct: 377 QTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD 436
Query: 232 SVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMR 291
Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M+
Sbjct: 437 LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMK 496
Query: 292 QKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVS 351
KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++ +
Sbjct: 497 SKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCT 556
Query: 352 TFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRL 410
FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS RL
Sbjct: 557 PFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRL 616
Query: 411 VTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAV 470
FL EE++P +++ G + IT+++ATF W++ PP L+ I ++P+G L+AV
Sbjct: 617 RIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAV 676
Query: 471 VGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPW 530
VG VG GKSSLLSALL E+ KVE G VA A+V + W
Sbjct: 677 VGQVGCGKSSLLSALLAEMDKVE------GHVAIKGSVAYVPQQA--------------W 716
Query: 531 LERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKA--AVYLLDDP 588
++ DS E I L G Q L YR A LL D
Sbjct: 717 IQN-----------DSLRENI----------LFGCQ-----LEEPYYRSVIQACALLPD- 749
Query: 589 LAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQE 648
L L + G + TRILVTH++ LPQ D IIV++ G I+EMGSYQE
Sbjct: 750 LEILPS-----------GDRTEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQE 798
Query: 649 LLQRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELRR 696
LL R GA L +Q + + G G + PG K SAG+ +L+R
Sbjct: 799 LLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQR 856
Query: 697 ERSIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRA 750
+ S S + +T+E Q + W + D Q G+VK +V+ Y++A
Sbjct: 857 QLSSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMKA 913
Query: 751 VGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIG 810
+G + ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I
Sbjct: 914 IGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIA 973
Query: 811 LFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPD 870
+F AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP+
Sbjct: 974 VFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPE 1033
Query: 871 KLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYS 930
++ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S S
Sbjct: 1034 VIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRS 1093
Query: 931 SVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNG 990
V SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN
Sbjct: 1094 PVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNC 1153
Query: 991 LVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAW 1050
+V AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+
Sbjct: 1154 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1213
Query: 1051 TPKEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRT 1110
T KEAPW++ A WPQ G++EF+++ LRYR +L ++ ++ I+ GEKVGIVGRT
Sbjct: 1214 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1273
Query: 1111 GAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLD 1170
GAGKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD
Sbjct: 1274 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1333
Query: 1171 LLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQ 1230
++SDE +W +LE LK V++LP +L ++CA+ GE+LSVGQ+QL+CLARALLRKT+
Sbjct: 1334 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1393
Query: 1231 ILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESG 1290
IL+LDEATAAVD T+ +Q+ + + F CTVL IAHRL ++MD RV+V+DKG++ E G
Sbjct: 1394 ILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG 1453
Query: 1291 SPAQLLAQKGLFYRLAQESGLV 1312
+P+ LL Q+GLFY +A+++GLV
Sbjct: 1454 APSDLLQQRGLFYSMAKDAGLV 1475
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 964 bits (2491), Expect = 0.0
Identities = 537/1355 (39%), Positives = 807/1355 (59%), Gaps = 67/1355 (4%)
Query: 13 PETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAA 72
P + A+F S T+ W ++ +GY+RPL +D+W + E ++ LVS+ E R A
Sbjct: 194 PSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKA 253
Query: 73 RRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRP------------------------L 108
RR A+ +++ S + P L + SQ + L
Sbjct: 254 RR---ALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWL 310
Query: 109 LKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLS 168
+KA+++ F+ L L +++D+F F P+LL L + F D W GYL A+L+F +
Sbjct: 311 MKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTA 370
Query: 169 ACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQR 228
A +Q+ Q L +++R+AI VY+K L LS+ +RK VG+ VNL+SVD Q+
Sbjct: 371 ALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQK 430
Query: 229 LTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEE 288
L + +++ LW ++ IV+ +LW+ LGPS L + V + ++P+N +S K Q +
Sbjct: 431 LMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVK 490
Query: 289 QMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSF 348
M+ KD R ++ + IL K +K+ WE +F D+V +R +EL L L V + F
Sbjct: 491 NMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVF 550
Query: 349 QVSTFLVALVVFAVHTLV-AENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSF 407
Q++ LV++V F+V+ LV + N ++A+KAF ++T+ NIL + LP I S++QA VS
Sbjct: 551 QLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVST 610
Query: 408 DRLVTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCL 467
+RL +L +++D A+ + A + A+F W +S + +NL + G L
Sbjct: 611 ERLEKYLGGDDLDTSAIRHDCNFDKA----MQFSEASFTWEHDSEATVRDVNLDIMAGQL 666
Query: 468 LAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELD 527
+AV+GPVG+GKSSL+SA+LGE+ V G ++I+G AYVPQ++W+QN ++ +N+ FG E +
Sbjct: 667 VAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFN 726
Query: 528 PPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDD 587
++VLEACAL PD++ P G IGE+G+NLSGGQKQR+SLARA Y+ +YLLDD
Sbjct: 727 EKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDD 786
Query: 588 PLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQ 647
PL+A+DAHVG+H+FN+V+GP GLL+G TR+LVTH++H LPQ D I+VL NG I E GSY
Sbjct: 787 PLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYS 846
Query: 648 ELLQRKGALVCLLDQ-ARQPGDRGEGETEPGTSTKDP--------------------RGT 686
LL +KG L R G E G+ +D R
Sbjct: 847 ALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRE 906
Query: 687 SAGRRPELRRERS----IKSVPE--KDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVK 740
++ RR R RS +KS+ K R + + + L + K+ I+ G+VK
Sbjct: 907 NSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKL---IKKEFIETGKVK 963
Query: 741 ATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQ----TQAALR 796
+++L YL+A+G + + F+ VA WLS W D + +Q +R
Sbjct: 964 FSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMR 1023
Query: 797 GGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNR 856
G++G LG Q I +F + G AS +L ++LL +++R+P+ FF+ TP G ++NR
Sbjct: 1024 VGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNR 1083
Query: 857 FSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVV 916
F+ + TVD +P LRS + G++ +++ +ATP+ T+ ++PL ++Y Q YV
Sbjct: 1084 FAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVS 1143
Query: 917 SSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVA 976
+S QLRRL+S + S + SH +ET G V+RAF Q F+ N R+D +Q+ F + +
Sbjct: 1144 TSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITS 1203
Query: 977 DRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLE 1036
+RWLA +EL+GN VF +A V+ + LS VGF +S AL +TQTL W+VR +++E
Sbjct: 1204 NRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIE 1263
Query: 1037 NSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQGVSF 1096
+IV+VER+ +Y EAPW + P WP G+I+F ++ +RYRPEL L ++G++
Sbjct: 1264 TNIVAVERITEYTKVENEAPW-VTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITC 1322
Query: 1097 KIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQ 1156
I + EK+G+VGRTGAGKSSL + L R+ EAA G I IDGV IA +GLH LR +++IIPQ
Sbjct: 1323 DIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQ 1382
Query: 1157 DPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQK 1216
DPILF GSLRMNLD +SDE IW ALE LK+ VASL L ++ + G +LS+GQ+
Sbjct: 1383 DPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQR 1442
Query: 1217 QLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCA 1276
QLLCL RALLRK++IL+LDEATAAVD T+ +Q + + FA CTV+ IAHRL ++MD
Sbjct: 1443 QLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSD 1502
Query: 1277 RVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGL 1311
+V+V+D G++ E GSP +LL G FY +A+E+G+
Sbjct: 1503 KVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 675 bits (1741), Expect = 0.0
Identities = 443/1327 (33%), Positives = 695/1327 (52%), Gaps = 86/1327 (6%)
Query: 11 PCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRS 70
P P A S+ FWW++ L G++R L D++S+ E+ S+ L L+ W ++
Sbjct: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFW--DKE 67
Query: 71 AARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLI-- 128
R N A Q+ S R ++K W+ S +LG +LI
Sbjct: 68 VLRAENDA---------------------QKPSLTRAIIKCYWK---SYLVLGIFTLIEE 103
Query: 129 ----ISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLK 184
I +F + K+++ F + Y A ++ + + Y ++
Sbjct: 104 SAKVIQPIF---LGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
Query: 185 VLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLV 244
MRLR A+ ++YRK L LS+ + + G +VNL+S DV + + ++L+ LW +
Sbjct: 161 CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL 220
Query: 245 WIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSIL 304
+ LW +G S L +AV + LLPL K + + + D+R R + ++
Sbjct: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
Query: 305 RNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHT 364
+ IK + WE +F + + +R +E+ + S L ++L SF ++ ++ V F +
Sbjct: 281 TGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYV 340
Query: 365 LVAENAMNAEKAFVTLTVLNILN-KAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGA 423
L+ + + A + FV +T+ + F P +I + +A VS R+ TFL L+E+
Sbjct: 341 LLG-SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRN 399
Query: 424 VDSSSSGSAAGKDCITIQSATFAWSQESP-PCLHRINLTVPQGCLLAVVGPVGAGKSSLL 482
S G K + +Q T W + S P L ++ TV G LLAVVGPVGAGKSSLL
Sbjct: 400 RQLPSDG----KKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLL 455
Query: 483 SALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQP 542
SA+LGEL+ G VS+ G +AYV Q+ WV + ++ N+ FG++ + E+V++ACAL+
Sbjct: 456 SAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKK 515
Query: 543 DVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFN 602
D+ +G T IG++G LSGGQK R++LARAVY+ A +YLLDDPL+A+DA V +H+F
Sbjct: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
Query: 603 QVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQ 662
I +L ILVTH L L A I++L +G + + G+Y E L+ LL
Sbjct: 576 LCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL-- 631
Query: 663 ARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDP 722
++ + E PGT P LR +S +++ + + L+
Sbjct: 632 -KKDNEESEQPPVPGT-------------PTLRNRTFSESSVWSQQSSRPSLKDGALESQ 677
Query: 723 DRAGWPA--GKDSIQYGRVKATVHLAYLRAVGTPLC-LYALFLFLCQQVASFCRGYWLSL 779
D P +++ G+V + Y RA + ++ + L QVA + +WLS
Sbjct: 678 DTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSY 737
Query: 780 WADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASM--AAVLLGGARA----------SR 827
WA+ ++ G + L +G+++ + A VL G AR+ S+
Sbjct: 738 WANKQSMLNVTVNGG--GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQ 795
Query: 828 LLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSL 887
L ++ ++++P+ FF+R PIG +LNRFSK+ +D +P + L + LL+V
Sbjct: 796 TLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLP---LTFLDFIQTLLQVVG 852
Query: 888 VVAVAT---PLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGST 944
VV+VA P + ++PL +++ + ++ +S ++RLES + S V SH++ + QG
Sbjct: 853 VVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLW 912
Query: 945 VVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKA 1004
+RA++ + +A D F L RW A ++ + V A +++
Sbjct: 913 TIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAK 972
Query: 1005 HLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAA 1064
L AG VG ++S AL + QW VR ++EN ++SVER+ +Y KEAPW
Sbjct: 973 TLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQK-RP 1031
Query: 1065 QPPWPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRL 1124
P WP G I F + Y P PL ++ ++ I + EKVGIVGRTGAGKSSL S L RL
Sbjct: 1032 PPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRL 1091
Query: 1125 QEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAAL 1184
E EG IWID + +GLH LR ++SIIPQ+P+LF G++R NLD EH+DE +W AL
Sbjct: 1092 SEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNAL 1150
Query: 1185 ETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPG 1244
+ VQLK + LPG++ + A+ G + SVGQ+QL+CLARA+LRK QILI+DEATA VDP
Sbjct: 1151 QEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPR 1210
Query: 1245 TELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK-GLFY 1303
T+ +Q + FA CTVL IAHRL +++D +++V+D G++ E P LL K LFY
Sbjct: 1211 TDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFY 1270
Query: 1304 RLAQESG 1310
++ Q+ G
Sbjct: 1271 KMVQQLG 1277
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 635 bits (1638), Expect = 0.0
Identities = 344/716 (48%), Positives = 477/716 (66%), Gaps = 23/716 (3%)
Query: 615 TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL------DQARQPGD 668
TRILVTH++ LPQ D IIV++ G I+EMGSYQELL R GA L +Q + +
Sbjct: 706 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEE 765
Query: 669 RG-EGETEPGTSTKDPRG-----TSAGRRPELRRERSIKS-----VPEKDRTTSEAQTEV 717
G G + PG K SAG+ +L+R+ S S + +T+E Q
Sbjct: 766 NGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQLSSSSSYSGDISRHHNSTAELQKA- 822
Query: 718 PLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYW 776
+ W + D Q G+VK +V+ Y++A+G + ++FLF+C V++ YW
Sbjct: 823 --EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYW 880
Query: 777 LSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWD 836
LSLW DDP V G Q +R ++G LG Q I +F AV +GG ASR L LL
Sbjct: 881 LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 940
Query: 837 VVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLA 896
++RSP+SFFERTP G+L+NRFSKE DTVD IP+ ++ + F ++ +V+ +ATP+A
Sbjct: 941 ILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIA 1000
Query: 897 TVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFV 956
+ I PL L+Y Q YV SS QL+RLES S S V SH ET G +V+RAF Q F+
Sbjct: 1001 AIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFI 1060
Query: 957 AQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVS 1016
Q++ +VDE+Q+ +P +VA+RWLA +E +GN +V AA AV+S+ LSAGLVG SVS
Sbjct: 1061 HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVS 1120
Query: 1017 AALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEF 1076
+LQVT L W+VR +++E +IV+VER+++Y+ T KEAPW++ A WPQ G++EF
Sbjct: 1121 YSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEF 1180
Query: 1077 QDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDG 1136
+++ LRYR +L ++ ++ I+ GEKVGIVGRTGAGKSSL GL R+ E+AEG I IDG
Sbjct: 1181 RNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDG 1240
Query: 1137 VPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASL 1196
+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD ++SDE +W +LE LK V++L
Sbjct: 1241 INIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSAL 1300
Query: 1197 PGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSW 1256
P +L ++CA+ GE+LSVGQ+QL+CLARALLRKT+IL+LDEATAAVD T+ +Q+ + +
Sbjct: 1301 PDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQ 1360
Query: 1257 FAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1312
F CTVL IAHRL ++MD RV+V+DKG++ E G+P+ LL Q+GLFY +A+++GLV
Sbjct: 1361 FEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1416
Score = 388 bits (997), Expect = e-107
Identities = 205/523 (39%), Positives = 316/523 (60%), Gaps = 16/523 (3%)
Query: 1 MFTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSR 60
+F+ + NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 197 LFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPV 256
Query: 61 LEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLKA 111
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 257 LVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKV 316
Query: 112 IWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACL 171
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++ACL
Sbjct: 317 LYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACL 376
Query: 172 QTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTE 231
QTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR +
Sbjct: 377 QTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD 436
Query: 232 SVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMR 291
Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M+
Sbjct: 437 LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMK 496
Query: 292 QKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVS 351
KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++ +
Sbjct: 497 SKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCT 556
Query: 352 TFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRL 410
FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS RL
Sbjct: 557 PFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRL 616
Query: 411 VTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAV 470
FL EE++P +++ G + IT+++ATF W++ PP L+ I ++P+G L+AV
Sbjct: 617 RIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAV 676
Query: 471 VGPVGAGKSSLLSALLGELSKVEGFVSIE------GAVAYVPQ 507
VG VG GKSSLLSALL E+ KVEG V+I+ +++Y+PQ
Sbjct: 677 VGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQ 719
Score = 82.0 bits (201), Expect = 3e-15
Identities = 62/222 (27%), Positives = 102/222 (45%), Gaps = 16/222 (7%)
Query: 455 LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------------- 501
L IN+T+ G + +VG GAGKSSL L EG + I+G
Sbjct: 1195 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1254
Query: 502 VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMN 561
+ +PQ+ + + S+ N+ + + LE L+ V + P+ + E G N
Sbjct: 1255 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1314
Query: 562 LSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTH 621
LS GQ+Q + LARA+ RK + +LD+ AA+D + + + + T + + H
Sbjct: 1315 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAH 1371
Query: 622 ALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQA 663
L+ + +IVL G I E G+ +LLQ++G + A
Sbjct: 1372 RLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDA 1413
Score = 40.4 bits (93), Expect = 0.011
Identities = 20/47 (42%), Positives = 27/47 (57%)
Query: 1088 PLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWI 1134
P + G++F I G V +VG+ G GKSSL S LL + EG + I
Sbjct: 658 PPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 610 bits (1572), Expect = e-174
Identities = 431/1391 (30%), Positives = 673/1391 (48%), Gaps = 159/1391 (11%)
Query: 21 SKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIA 80
SK T+WW++ + +++P+ DL ++G+ + ++ ++ + +
Sbjct: 226 SKGTYWWMNAFIKTAHKKPI---DLRAIGKLPIAMRALTNYQR-------LCEAFDAQVR 275
Query: 81 FKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKL 140
+G G +A + +A+ F +L + I++D+ F P
Sbjct: 276 KDIQGTQGARA----------------IWQALSHAFGRRLVLSSTFRILADLLGFAGPLC 319
Query: 141 LSLFLEFIG------DPKPPAW------------KGYLLAVLMFLSACLQTLFEQQNMYR 182
+ ++ +G PK Y+LAVL+FL+ LQ F Q + Y
Sbjct: 320 IFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYV 379
Query: 183 LKVLQMRLRSAITGLVYRKVLALSSG--SRKASAVGDVVNLVSVDVQRLTESVLYLNGLW 240
+ LR AI +Y K++ LS+ S G + NLV++D +L LW
Sbjct: 380 AIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLW 439
Query: 241 LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLT 300
V I+V + L+ +LG SAL AV + L P+ +F++ K + Q + + R + T
Sbjct: 440 AMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQT 499
Query: 301 SSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVF 360
+ +LR K +K + WE F RV R +E+ +LR + S+S+ L+ F
Sbjct: 500 NEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITF 559
Query: 361 AVHTLVAENA-MNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEV 419
H + A + AF +L++ +IL L + S V+A VS +L FL E+
Sbjct: 560 VGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEI 619
Query: 420 --------DP-------------------------------GAVDS--SSSGSAAGKDCI 438
+P G + S S+ A C+
Sbjct: 620 REEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCV 679
Query: 439 TIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV-- 496
I F W+ + P L I + +P+G L +VG VG GKSSLL A LGE+ KV G V
Sbjct: 680 QIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFW 739
Query: 497 ------------------------SIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLE 532
G VAY Q+ W+ N +V EN+ F + +
Sbjct: 740 SSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYK 799
Query: 533 RVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAAL 592
V+EAC+LQPD+D P G T IGE+G+NLSGGQ+QR+S+ARA+Y+ A V LDDP +AL
Sbjct: 800 MVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSAL 859
Query: 593 DAHVGQHVFNQVIGPGGLLQGTTR--ILVTHALHILPQADWIIVLANGAIAEMGSYQELL 650
D H+ H+ G LL+ R +LVTH L LP ADWII + +G I G+ ++
Sbjct: 860 DIHLSDHLMQA--GILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQ 917
Query: 651 QRKGALVCLLDQARQPGDRGEGETEPGT-----STKDPRGTSAGRRPELRRERSIKSVPE 705
+ + L + + +R + E E T +T+ P+G S R R+ ++ E
Sbjct: 918 RSECQL---FEHWKTLMNRQDQELEKETVTERKATEPPQGLS---RAMSSRDGLLQDEEE 971
Query: 706 KDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLC 765
++ +E++ + L Q + YL + G L +F L
Sbjct: 972 EEEEAAESEEDDNLSSMLH----------QRAEIPWRACAKYLSSAGILLLSLLVFSQLL 1021
Query: 766 QQVASFCRGYWLSLWADD-----PAVGG---------QQTQAALRGGIFGLLGCLQAIGL 811
+ + YWL+ W D PA QT A+ +F +L L +
Sbjct: 1022 KHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAM---VFTVLCSLGIVLC 1078
Query: 812 FASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDK 871
+ V G + ++ L + LL ++ +P+ FFE TP+G +LNRFS + +T+D IP
Sbjct: 1079 LVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPST 1138
Query: 872 LRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSS 931
L L + V++ TP+ VA+LPL ++ Q + V+S L++L+ +
Sbjct: 1139 LECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLP 1198
Query: 932 VCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGL 991
+ SH AET +G T +RAFR +A F + D + S A+RWL +E +G +
Sbjct: 1199 LLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACV 1258
Query: 992 VFAAATCAVLSKAH--LSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYA 1049
V AA ++ + H LSAGLVG ++ AL V+ L W+VRN D+E + +V+R+
Sbjct: 1259 VLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLL 1318
Query: 1050 WTPKEAPWRLPTCAAQPP-WPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVG 1108
T E+ L + P WP G+I+ Q+ +RY L ++ V+ I G+K+GI G
Sbjct: 1319 KTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICG 1378
Query: 1109 RTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMN 1168
RTG+GKSS + R+ + EG I IDG+ IA + LHTLRSR+SII QDP+LF G++R N
Sbjct: 1379 RTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFN 1438
Query: 1169 LDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRK 1228
LD ++ SD +W ALE QLK +V +LPG L + GE+ S GQ+QL CLARA +RK
Sbjct: 1439 LDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRK 1498
Query: 1229 TQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAE 1288
T I I+DEATA++D TE +Q ++ + FA TV+ IAHR+ +++ V+V+ +G + E
Sbjct: 1499 TSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILE 1558
Query: 1289 SGSPAQLLAQK 1299
P +LL++K
Sbjct: 1559 FDKPEKLLSRK 1569
Score = 90.9 bits (224), Expect = 7e-18
Identities = 67/232 (28%), Positives = 109/232 (46%), Gaps = 16/232 (6%)
Query: 438 ITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS 497
I IQ+ + + P L +N + G + + G G+GKSS A + EG +
Sbjct: 1344 IQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHII 1403
Query: 498 IEGA-VAYVPQEAWVQNTSVV--ENVCFGQ----ELDPP------WLERVLEACALQPDV 544
I+G +A +P S++ + V F LDP L LE L+ V
Sbjct: 1404 IDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVV 1463
Query: 545 DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 604
+ P G+ I E G N S GQ+Q LARA RK +++++D+ A++D +++ +V
Sbjct: 1464 KALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMAT-ENILQKV 1522
Query: 605 IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGAL 656
+ T + + H +H + AD +IVL GAI E ++LL RK ++
Sbjct: 1523 VMTA--FADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSV 1572
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 609 bits (1570), Expect = e-174
Identities = 429/1331 (32%), Positives = 669/1331 (50%), Gaps = 92/1331 (6%)
Query: 21 SKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIA 80
SKAT+WW++ L+ +++P+ DL ++G+ + R ++ + A K +A
Sbjct: 224 SKATYWWMNTLIISAHKKPI---DLKAIGKL----PIAMRAVTNYVCLKDAYEEQKKKVA 276
Query: 81 FKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKL 140
P P S W A+++ F LL + ++D+ F P
Sbjct: 277 ---------DHPNRTP------SIWL----AMYRAFGRPILLSSTFRYLADLLGFAGPLC 317
Query: 141 LSLFLEFIGDP----------------KPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLK 184
+S ++ + + K Y+LAVL+FL+ LQ F Q + Y
Sbjct: 318 ISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTI 377
Query: 185 VLQMRLRSAITGLVYRKVLALSSG--SRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLP 242
+ LR A+ ++Y K+L LS+ S +G + NLV+++ +L + LW
Sbjct: 378 ETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
Query: 243 LVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSS 302
V I++ + L+ LLG SAL AV + L P+ +FI+ K Q+ + R + T+
Sbjct: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
Query: 303 ILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAV 362
IL+ K +K + WE F V R +EL +L+T L S+S+ L F
Sbjct: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
Query: 363 HTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPG 422
H + N + +AF +L++ +IL L + V+A +S +L FL +E+
Sbjct: 558 HAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDD 617
Query: 423 AV---DSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKS 479
+ +SS + K + + F+W L I++ +P G L +VG VG GKS
Sbjct: 618 SWRTGESSLPFESCKKHTGVVTNGYFSWGS-GLATLSNIDIRIPTGQLTMIVGQVGCGKS 676
Query: 480 SLLSALLGELSKVEGFV----------SIEG-------AVAYVPQEAWVQNTSVVENVCF 522
SLL A+LGE+ +EG V S E +VAY Q+ W+ N +V EN+ F
Sbjct: 677 SLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITF 736
Query: 523 GQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAV 582
G + + V +AC+LQPD+D P G T IGE+G+NLSGGQ+QR+ +ARA+Y+ +
Sbjct: 737 GSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNI 796
Query: 583 YLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAE 642
LDDP +ALD H+ H+ + I T +LVTH L L ADWII + +G++
Sbjct: 797 VFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLR 856
Query: 643 MGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKS 702
G+ +++ + V L + + +R + E E T+ R+ R S ++
Sbjct: 857 EGTLKDIQTKD---VELYEHWKTLMNRQDQELEKDMEADQ---TTLERKTLRRAMYSREA 910
Query: 703 VPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLA--YLRAVGTPLCLYAL 760
+ + E + E DD ++ R K YL + G L + +
Sbjct: 911 KAQMEDEDEEEEEEEDEDD--------NMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMI 962
Query: 761 FLFLCQQVASFCRGYWLSLWADDPAVG--GQQTQAALRGGIFGLLGCLQAIGLFASMAAV 818
F L + YWL+ W + ++ G+ Q G L G + L S+
Sbjct: 963 FSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVE 1022
Query: 819 LLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMY 878
+G A++ L LL ++ PI FF+ TP+G +LNRFS +T+ +D IP L SL
Sbjct: 1023 WMG-LTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRS 1081
Query: 879 AFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAE 938
L +++ ATP+ VA+LPL + + Q + V+S L+ L+ ++ + H +E
Sbjct: 1082 TLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSE 1141
Query: 939 TFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRL-VADRWLAANVELLGNGLVFAAAT 997
T +G T +RAFR + F Q + ++ I++ L A+RWL + LG +V A+
Sbjct: 1142 TAEGLTTIRAFRHETRF-KQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASI 1200
Query: 998 CAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPW 1057
++ ++ +GLVG + AL +T L WVVRN DLE + +V+++ + T + +
Sbjct: 1201 ASISGSSN--SGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFL-TMESENY 1257
Query: 1058 RLPTCAAQPP--WPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKS 1115
+Q P WPQ G+I+ D +RY L ++ V I G+KVGI GRTG+GKS
Sbjct: 1258 EGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKS 1317
Query: 1116 SLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEH 1175
SL+ R+ + +G I IDG+ I+ + LHTLRSR+SII QDPILF GS+R NLD +
Sbjct: 1318 SLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKC 1377
Query: 1176 SDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILD 1235
+D+ +W ALE QLK +V SLPG L + GE+ SVGQ+QL CLARA +RK+ ILI+D
Sbjct: 1378 TDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMD 1437
Query: 1236 EATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQL 1295
EATA++D TE +Q ++ + FA TV+ IAHR+ S+MD VLV +G + E + L
Sbjct: 1438 EATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNL 1497
Query: 1296 LAQK-GLFYRL 1305
LA K GLF L
Sbjct: 1498 LAHKNGLFSTL 1508
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 597 bits (1540), Expect = e-170
Identities = 438/1361 (32%), Positives = 677/1361 (49%), Gaps = 144/1361 (10%)
Query: 14 ETGAAFPSKATFWWVSGLVWRGYRRPLR-PKDLWSLGRENSSEELVSRLEKEWMRNRSAA 72
E G ++ S+ ++ W++ L+ RG LR P+D+ L L + W
Sbjct: 172 EDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHW------- 224
Query: 73 RRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDV 132
QEG++ L +A++ F +L L ++ +
Sbjct: 225 ---------------------------QEGAR---LWRALYGAFGRCYLALGLLKLVGTM 254
Query: 133 FRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRS 192
F+ P LLSL + F+ + + P G L A+ + A L + + Q Y + + ++ R
Sbjct: 255 LGFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARG 314
Query: 193 AITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLW-LPLVWIVVCFV 251
A+ ++Y K L L G+ +NL+ D +RL + W LPL + ++
Sbjct: 315 AVLNILYCKALQLGPSR---PPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYL 371
Query: 252 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIK 311
L+Q +G + + + + L L+P+N I+ + +E ++ KD+R +L + +L + IK
Sbjct: 372 -LYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIK 430
Query: 312 FHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAM 371
F GWE A RV R +ELG LR L + + + ++++V+F + L+ +
Sbjct: 431 FCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQ-L 489
Query: 372 NAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGAVDSSSSGS 431
A K F L ++ +L P+ I+ L++A+VS DR+ FL L +P A S G
Sbjct: 490 TATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGR 549
Query: 432 --------------AAGKDCITIQSATFAWSQESPPCLHRIN-LTVPQGCLLAVVGPVGA 476
A + + A F+W I+ L V +G L+ +VG VG
Sbjct: 550 LGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGC 609
Query: 477 GKSSLLSALLGELSKVEGFVSIEG---AVAYVPQEAWVQNTSVVENVCFGQELDPPWLER 533
GKSSLL+A+ GEL ++ G V++ G QE W+Q ++ +N+ FG+ D +
Sbjct: 610 GKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKE 669
Query: 534 VLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALD 593
VLEACAL D+ P G T +GE+G+ LSGGQ+ R++LARAVY++ +YLLDDPLAA+D
Sbjct: 670 VLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVD 729
Query: 594 AHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRK 653
A V H+ ++ I G+L TTR+L TH L +AD ++++ G + G E+L
Sbjct: 730 ADVANHLLHRCIL--GMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEILP-- 785
Query: 654 GALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEA 713
LV + +A + E ++ S ++P T G E++++TS
Sbjct: 786 --LVQAVPKAWAENGQ-ESDSATAQSVQNPEKTKEGL--------------EEEQSTS-- 826
Query: 714 QTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCR 773
G ++S + G V V+ AY +AVG L L LF L Q
Sbjct: 827 ------------GRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAA 874
Query: 774 GYWLSLW-----ADDPAVGGQQTQAALRGGIFGLLGCLQAIG------------------ 810
+WLS W A++ + Q + + G+F L + G
Sbjct: 875 DWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSS 934
Query: 811 -------LFASMAAV------------LLGGARASRLLFQRLLWDVVRSPISFFERTPIG 851
++A++A V G +A+ L +RLL V+ +P++FF TP G
Sbjct: 935 DIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTG 994
Query: 852 HLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQ 911
+LNRFS + D +P L LL A GLL + V+ P + + PL ++Y Q
Sbjct: 995 RILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQ 1054
Query: 912 SLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISF 971
Y SS +LRRL S + S + SH+A+T G +V+RA F +N ++ +QR F
Sbjct: 1055 RHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQF 1114
Query: 972 PRLVADRWLAANVELLGNGLVFAAATCAVLSKAH--LSAGLVGFSVSAALQVTQTLQWVV 1029
+WL ++L+G +V A A A++ + GLVG S+S AL +T L +V
Sbjct: 1115 ATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLV 1174
Query: 1030 RNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPL 1089
++T E +VSVER+++Y + P P QGG +EFQD L YRP LP
Sbjct: 1175 SSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGG-VEFQDVVLAYRPGLPN 1233
Query: 1090 AVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRS 1149
A+ GV+F + GEK+GIVGRTG+GKSSL L RL E + G + +DGV + + L LRS
Sbjct: 1234 ALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRS 1293
Query: 1150 RISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGE 1209
+++IIPQ+P LF G++R NLD H D A+W AL+ L ++ S+ G L + + G
Sbjct: 1294 QLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGR 1352
Query: 1210 DLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRL 1269
LS+GQ+QLLCLARALL +IL +DEATA+VD T+ +Q + FA TVL IAHRL
Sbjct: 1353 SLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRL 1412
Query: 1270 RSVMDCARVLVMDKGQVAESGSPAQLLAQ-KGLFYRLAQES 1309
++++ RVLV+ G+V E SPA L Q LF +L Q S
Sbjct: 1413 NTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSS 1453
Score = 82.8 bits (203), Expect = 2e-15
Identities = 78/282 (27%), Positives = 121/282 (42%), Gaps = 29/282 (10%)
Query: 405 VSFDRLVTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQ 464
VS +RL + C +P + + Q A+ P L + V
Sbjct: 1185 VSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQP 1244
Query: 465 GCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA-------------VAYVPQEAWV 511
G L +VG G+GKSSLL L L G V ++G +A +PQE ++
Sbjct: 1245 GEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFL 1304
Query: 512 QNTSVVENVCFGQELDPPWLER------VLEACALQPDVDSFPEGIHTSIGEQGMNLSGG 565
+ +V EN LDP L + L+ C L + S G+ +GE G +LS G
Sbjct: 1305 FSGTVREN------LDPQGLHKDRALWQALKQCHLSEVITSMG-GLDGELGEGGRSLSLG 1357
Query: 566 QKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHI 625
Q+Q L LARA+ A + +D+ A++D Q + Q I T + + H L+
Sbjct: 1358 QRQLLCLARALLTDAKILCIDEATASVDQKTDQ-LLQQTICK--RFANKTVLTIAHRLNT 1414
Query: 626 LPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPG 667
+ +D ++VL G + E+ S L + +L L Q+ Q G
Sbjct: 1415 ILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQG 1456
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 597 bits (1539), Expect = e-170
Identities = 432/1367 (31%), Positives = 671/1367 (49%), Gaps = 128/1367 (9%)
Query: 21 SKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIA 80
SKAT+WW++ L+ +++P+ DL ++G+ + R ++ + A K +A
Sbjct: 224 SKATYWWMNTLIISAHKKPI---DLKAIGKL----PIAMRAVTNYVCLKDAYEEQKKKVA 276
Query: 81 FKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKL 140
P P S W A+++ F LL + ++D+ F P
Sbjct: 277 ---------DHPNRTP------SIWL----AMYRAFGRPILLSSTFRYLADLLGFAGPLC 317
Query: 141 LSLFLEFIGDP----------------KPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLK 184
+S ++ + + K Y+LAVL+FL+ LQ F Q + Y
Sbjct: 318 ISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTI 377
Query: 185 VLQMRLRSAITGLVYRKVLALSSG--SRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLP 242
+ LR A+ ++Y K+L LS+ S +G + NLV+++ +L + LW
Sbjct: 378 ETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
Query: 243 LVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSS 302
V I++ + L+ LLG SAL AV + L P+ +FI+ K Q+ + R + T+
Sbjct: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
Query: 303 ILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAV 362
IL+ K +K + WE F V R +EL +L+T L S+S+ L F
Sbjct: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
Query: 363 HTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEE---- 418
H + N + +AF +L++ +IL L + V+A +S +L FL +E
Sbjct: 558 HAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDD 617
Query: 419 -------------------VDPGAVDSSSSGS---------------AAGKD-CITIQSA 443
V P ++ G A +D I + +
Sbjct: 618 SWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNG 677
Query: 444 TFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV------- 496
F+W L I++ +P G L +VG VG GKSSLL A+LGE+ +EG V
Sbjct: 678 YFSWGS-GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNE 736
Query: 497 ---SIEG-------AVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDS 546
S E +VAY Q+ W+ N +V EN+ FG + + V +AC+LQPD+D
Sbjct: 737 SEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDL 796
Query: 547 FPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIG 606
P G T IGE+G+NLSGGQ+QR+ +ARA+Y+ + LDDP +ALD H+ H+ + I
Sbjct: 797 LPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGIL 856
Query: 607 PGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQP 666
T +LVTH L L ADWII + +G++ G+ +++ + V L + +
Sbjct: 857 KFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHWKTL 913
Query: 667 GDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAG 726
+R + E E T+ R+ R S ++ + + E + E DD
Sbjct: 914 MNRQDQELEKDMEADQ---TTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----- 965
Query: 727 WPAGKDSIQYGRVKATVHLA--YLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDP 784
++ R K YL + G L + +F L + YWL+ W +
Sbjct: 966 ---NMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEY 1022
Query: 785 AVG--GQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPI 842
++ G+ Q G L G + L S+ +G A++ L LL ++ PI
Sbjct: 1023 SINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMG-LTAAKNLHHNLLNKIILGPI 1081
Query: 843 SFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILP 902
FF+ TP+G +LNRFS +T+ +D IP L SL L +++ ATP+ VA+LP
Sbjct: 1082 RFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLP 1141
Query: 903 LFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNAR 962
L + + Q + V+S L+ L+ ++ + H +ET +G T +RAFR + F Q
Sbjct: 1142 LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF-KQRMLE 1200
Query: 963 VDESQRISFPRL-VADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQV 1021
+ ++ I++ L A+RWL + LG +V A+ ++ ++ +GLVG + AL +
Sbjct: 1201 LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSN--SGLVGLGLLYALTI 1258
Query: 1022 TQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPP--WPQGGQIEFQDF 1079
T L WVVRN DLE + +V+++ + T + + +Q P WPQ G+I+ D
Sbjct: 1259 TNYLNWVVRNLADLEVQMGAVKKVNSFL-TMESENYEGTMDPSQVPEHWPQEGEIKIHDL 1317
Query: 1080 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1139
+RY L ++ V I G+KVGI GRTG+GKSSL+ R+ + +G I IDG+ I
Sbjct: 1318 CVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDI 1377
Query: 1140 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQ 1199
+ + LHTLRSR+SII QDPILF GS+R NLD + +D+ +W ALE QLK +V SLPG
Sbjct: 1378 SKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGG 1437
Query: 1200 LQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQ 1259
L + GE+ SVGQ+QL CLARA +RK+ ILI+DEATA++D TE +Q ++ + FA
Sbjct: 1438 LDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFAD 1497
Query: 1260 CTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK-GLFYRL 1305
TV+ IAHR+ S+MD VLV +G + E + LLA K GLF L
Sbjct: 1498 RTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1544
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 596 bits (1537), Expect = e-170
Identities = 428/1364 (31%), Positives = 672/1364 (49%), Gaps = 128/1364 (9%)
Query: 21 SKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIA 80
SKAT+WW++ L+ +++P+ DL ++G+ + R ++ + A K +A
Sbjct: 224 SKATYWWMNTLIISAHKKPI---DLKAIGKL----PIAMRAVTNYVCLKDAYEEQKKKVA 276
Query: 81 FKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKL 140
P P S W A+++ F LL + ++D+ F P
Sbjct: 277 ---------DHPNRTP------SIWL----AMYRAFGRPILLSSTFRYLADLLGFAGPLC 317
Query: 141 LSLFLEFIGDP----------------KPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLK 184
+S ++ + + K Y+LAVL+FL+ LQ F Q + Y
Sbjct: 318 ISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTI 377
Query: 185 VLQMRLRSAITGLVYRKVLALSSG--SRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLP 242
+ LR A+ ++Y K+L LS+ S +G + NLV+++ +L + LW
Sbjct: 378 ETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
Query: 243 LVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSS 302
V I++ + L+ LLG SAL AV + L P+ +FI+ K Q+ + R + T+
Sbjct: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
Query: 303 ILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAV 362
IL+ K +K + WE F V R +EL +L+T L S+S+ L F
Sbjct: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
Query: 363 HTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEE---- 418
H + N + +AF +L++ +IL L + V+A +S +L FL +E
Sbjct: 558 HAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDD 617
Query: 419 -------------------VDPGAVDSSSSGS---------------AAGKD-CITIQSA 443
V P ++ G A +D I + +
Sbjct: 618 SWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNG 677
Query: 444 TFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV------- 496
F+W L I++ +P G L +VG VG GKSSLL A+LGE+ +EG V
Sbjct: 678 YFSWGS-GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNE 736
Query: 497 ---SIEG-------AVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDS 546
S E +VAY Q+ W+ N +V EN+ FG + + V +AC+LQPD+D
Sbjct: 737 SEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDL 796
Query: 547 FPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIG 606
P G T IGE+G+NLSGGQ+QR+ +ARA+Y+ + LDDP +ALD H+ H+ + I
Sbjct: 797 LPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGIL 856
Query: 607 PGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQP 666
T +LVTH L L ADWII + +G++ G+ +++ + V L + +
Sbjct: 857 KFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHWKTL 913
Query: 667 GDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAG 726
+R + E E T+ R+ R S ++ + + E + E DD
Sbjct: 914 MNRQDQELEKDMEADQ---TTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----- 965
Query: 727 WPAGKDSIQYGRVKATVHLA--YLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDP 784
++ R K YL + G L + +F L + YWL+ W +
Sbjct: 966 ---NMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEY 1022
Query: 785 AVG--GQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPI 842
++ G+ Q G L G + L S+ +G A++ L LL ++ PI
Sbjct: 1023 SINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMG-LTAAKNLHHNLLNKIILGPI 1081
Query: 843 SFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILP 902
FF+ TP+G +LNRFS +T+ +D IP L SL L +++ ATP+ VA+LP
Sbjct: 1082 RFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLP 1141
Query: 903 LFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNAR 962
L + + Q + V+S L+ L+ ++ + H +ET +G T +RAFR + F Q
Sbjct: 1142 LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF-KQRMLE 1200
Query: 963 VDESQRISFPRL-VADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQV 1021
+ ++ I++ L A+RWL + LG +V A+ ++ ++ +GLVG + AL +
Sbjct: 1201 LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSN--SGLVGLGLLYALTI 1258
Query: 1022 TQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPP--WPQGGQIEFQDF 1079
T L WVVRN DLE + +V+++ + T + + +Q P WPQ G+I+ D
Sbjct: 1259 TNYLNWVVRNLADLEVQMGAVKKVNSFL-TMESENYEGTMDPSQVPEHWPQEGEIKIHDL 1317
Query: 1080 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1139
+RY L ++ V I G+KVGI GRTG+GKSSL+ R+ + +G I IDG+ I
Sbjct: 1318 CVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDI 1377
Query: 1140 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQ 1199
+ + LHTLRSR+SII QDPILF GS+R NLD + +D+ +W ALE QLK +V SLPG
Sbjct: 1378 SKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGG 1437
Query: 1200 LQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQ 1259
L + GE+ SVGQ+QL CLARA +RK+ ILI+DEATA++D TE +Q ++ + FA
Sbjct: 1438 LDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFAD 1497
Query: 1260 CTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK-GLF 1302
TV+ IAHR+ +++ V+VM +G + E +P LLAQ+ G+F
Sbjct: 1498 RTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVF 1541
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 582 bits (1501), Expect = e-166
Identities = 412/1368 (30%), Positives = 679/1368 (49%), Gaps = 145/1368 (10%)
Query: 11 PCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRS 70
P P A S ATF W++ ++ +GYR+ L L L +SS+ R W
Sbjct: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLW----- 97
Query: 71 AARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIIS 130
+ + + G + L +W+ + L+ ++ I+
Sbjct: 98 ------------------------DEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILC 133
Query: 131 DVFRFTVPKLL-SLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMR 189
+ P +L L+ W G L + +F + + F +R
Sbjct: 134 IIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIR 193
Query: 190 LRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVC 249
L+ A++ LV+ +++ + + +VG+V+N++S D L E+ L+ + +V C
Sbjct: 194 LKVALSTLVFENLVSFKTLTH--ISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFC 251
Query: 250 FVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKT 309
Y + +LGP+AL I+V++ +P+ F++K + + + D R + + L +
Sbjct: 252 AAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRL 311
Query: 310 IKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAEN 369
IK + WE +F + + IR +E L +G + S + + + + ++ + H L+
Sbjct: 312 IKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRK 371
Query: 370 AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLC--------LEEVDP 421
+ A AF + + N++ + A LPFSI ++ +A VS R+ L + DP
Sbjct: 372 -LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDP 430
Query: 422 GAV----------DSSSSGSAAGKDC------ITIQSATFAWSQESPPC----------- 454
V + +S + K + + + A+S+ SPP
Sbjct: 431 DTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSD 490
Query: 455 -----LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEA 509
LH I+ V +G +L + G VG+GKSSLL+ALLG++ +G V++ G +AYV Q+A
Sbjct: 491 SLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQA 550
Query: 510 WVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQR 569
W+ + +V EN+ FG++ D + + C LQ D+ + P G T IGE+G+NLSGGQ+QR
Sbjct: 551 WIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQR 610
Query: 570 LSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQA 629
+SLARAVY +YLLDDPL+A+DAHVG+HVF + I L+G T +LVTH L L
Sbjct: 611 ISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKK--TLRGKTVVLVTHQLQFLESC 668
Query: 630 DWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRG---- 685
D +I+L +G I E G+++EL++ +G L+ R G KDP
Sbjct: 669 DEVILLEDGEICEKGTHKELMEERGRYAKLIHNLR------------GLQFKDPEHLYNA 716
Query: 686 --TSAGRRPELRRERSI----------KSVPEKDRTTSE-AQTEVPLDDPDRAGWPAGKD 732
A + RE K ++ T SE T+VP + +
Sbjct: 717 AMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQT------E 770
Query: 733 SIQYGRVKATVHLAYLRAV-GTPLCLYALFLFLCQQVASFCRGYWLSLWADDPA-----V 786
S Q G V + Y++A G L L+ +FLFL ++ +WL LW D +
Sbjct: 771 SPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGP 830
Query: 787 GGQQTQAALRGGIFGLLGCLQAIGLF-ASMAAVLLGGA-----------RASRLLFQRLL 834
G +T + G + +G ++ ASM +L+ G AS L +
Sbjct: 831 QGNRTMCEV-GAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVF 889
Query: 835 WDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP 894
+++SP+SFF+ TP G L+NRFSK+ D +DV +P + L F ++ + +++A P
Sbjct: 890 DKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFP 949
Query: 895 LATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAP 954
+ + L + + ++ +L+++E+ S S +H+ + QG ++ A+ +
Sbjct: 950 AVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKES 1009
Query: 955 FVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFS 1014
+ + + A RW A +++L N L F A LS + +S G S
Sbjct: 1010 CITYHLLYFN----------CALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLS 1059
Query: 1015 VSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWT--PK-EAPWRLPTCAAQPPWPQG 1071
+S +Q++ LQ VR T+ + SVE +++Y T P+ P ++ TC WP
Sbjct: 1060 LSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKD--WPSR 1117
Query: 1072 GQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGG 1131
G+I F+D+ +RYR PL + ++ I +G+ VGIVGRTG+GKSSL L RL E A G
Sbjct: 1118 GEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGT 1177
Query: 1132 IWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKA 1191
I+ID V I + L LR+++++IPQDP+LF G++R NLD + H+DE +W LE ++
Sbjct: 1178 IFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRD 1237
Query: 1192 LVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQA 1251
+ LP +LQ + + GE+ SVG++QLLC+ARALLR ++I++LDEATA++D T+ +Q
Sbjct: 1238 TIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQN 1297
Query: 1252 MLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK 1299
+ F CTVL IAHRL +V++C VLVM+ G+V E P ++LA+K
Sbjct: 1298 TIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKP-EVLAEK 1344
Score = 89.7 bits (221), Expect = 2e-17
Identities = 55/220 (25%), Positives = 114/220 (51%), Gaps = 14/220 (6%)
Query: 1087 LPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHT 1146
L + +SF + G+ +GI G G+GKSSL + LL + +G + ++G
Sbjct: 492 LKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT--------- 542
Query: 1147 LRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCAD 1206
++ + Q +F G++R N+ +++ + + L+ +++LP + +
Sbjct: 543 ----LAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
Query: 1207 RGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLI 1265
RG +LS GQ+Q + LARA+ Q+ +LD+ +AVD + + + TV+L+
Sbjct: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
Query: 1266 AHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1305
H+L+ + C V++++ G++ E G+ +L+ ++G + +L
Sbjct: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
Score = 87.0 bits (214), Expect = 1e-16
Identities = 101/492 (20%), Positives = 203/492 (41%), Gaps = 44/492 (8%)
Query: 192 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 251
S++ V+ K+L + G ++N S D+ L + + +L ++VV +
Sbjct: 882 SSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFIL 941
Query: 252 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRAR------LTSSILR 305
+ + P+ L +A L + FFI + H +++++ ++ +R +TSS+
Sbjct: 942 VILAAVFPAVLLVVAS----LAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQG 997
Query: 306 NSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTL 365
+ E +L ALR L V + + TF VAL+V +
Sbjct: 998 LGIIHAYGKKESCITYHLLYFNC----ALRWFALRMDVLM---NILTFTVALLVTLSFSS 1050
Query: 366 VAENAMNAEKAFVT----LTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDP 421
++ ++ +++ L + + + F+ L++ +S C+ E
Sbjct: 1051 ISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYIS-------TCVPECTH 1103
Query: 422 GAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSL 481
+ + IT + + +P L +NL + G + +VG G+GKSSL
Sbjct: 1104 PLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSL 1163
Query: 482 LSALLGELSKVEGFVSIEGA-------------VAYVPQEAWVQNTSVVENVCFGQELDP 528
AL + G + I+ + +PQ+ + +V N+ +
Sbjct: 1164 GMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTD 1223
Query: 529 PWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDP 588
L +VLE ++ + PE + + E G N S G++Q L +ARA+ R + + LLD+
Sbjct: 1224 EMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEA 1283
Query: 589 LAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQE 648
A++D+ V N + +G T + + H L+ + D ++V+ NG + E +
Sbjct: 1284 TASMDSKTDTLVQNTI---KDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEV 1340
Query: 649 LLQRKGALVCLL 660
L ++ + +L
Sbjct: 1341 LAEKPDSAFAML 1352
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 568 bits (1463), Expect = e-161
Identities = 413/1366 (30%), Positives = 652/1366 (47%), Gaps = 143/1366 (10%)
Query: 7 KYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 66
++ P P A S T W++ L+ + R L + L ++S++ V RL + W
Sbjct: 79 RFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWE 138
Query: 67 RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV-FHSTFLLGTL 125
S R+G KA LR + + R + A+ + F +LG +
Sbjct: 139 EEVS------------RRGIE--KASVLLVMLRFQRT--RLIFDALLGICFCIASVLGPI 182
Query: 126 SLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKV 185
+I PK+L E +G+ G L +FLS C+++L + +
Sbjct: 183 LII---------PKILEYSEEQLGN----VVHGVGLCFALFLSECVKSLSFSSSWIINQR 229
Query: 186 LQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVW 245
+R R+A++ + K++ S S G+ ++ + DV L E V Y + +
Sbjct: 230 TAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLVLITCAS 287
Query: 246 IVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISK---KRNHHQEEQMRQKDSRARLTSS 302
+V+C + + ++G +A AI +L + PL F+++ K HH E D R R+TS
Sbjct: 288 LVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEV---SDQRIRVTSE 344
Query: 303 ILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAV 362
+L K IK + WE F + +R +E L GL+ S++ ++ + + V +
Sbjct: 345 VLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLI 404
Query: 363 HTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPG 422
HT + + + A AF L LN+L + F+P ++ L ++ + R F L+E
Sbjct: 405 HTSL-KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF-LQESPVF 462
Query: 423 AVDSSSSGSAAGKDCITIQSATFAWSQESP------------------------------ 452
V + S A + + AT +W Q P
Sbjct: 463 YVQTLQDPSKA----LVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEE 518
Query: 453 ------PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVP 506
P LH+INL V +G +L V G G+GKSSLLSA+L E+ +EG V ++G++AYVP
Sbjct: 519 EGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVP 578
Query: 507 QEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQ 566
Q+AW+ + ++ EN+ G D +VL C+L D++ P G T IGE+G+NLSGGQ
Sbjct: 579 QQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQ 638
Query: 567 KQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHIL 626
KQR+SLARAVY +YLLDDPL+A+DAHVG+H+F + I L+G T +LVTH L L
Sbjct: 639 KQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKK--TLRGKTVVLVTHQLQYL 696
Query: 627 PQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGT 686
II+L NG I E G++ EL+Q+KG L+ + + + + K P+
Sbjct: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEK-PKVE 755
Query: 687 SAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLA 746
S L + +VPE T E E G + V+
Sbjct: 756 SQALATSLEESLNGNAVPEHQLTQEEEMEE--------------------GSLSWRVYHH 795
Query: 747 YLRAVGTPLCLYALFLFLCQQV-ASFCRGYWLSLW-----------------------AD 782
Y++A G + +F F+ V + +WLS W AD
Sbjct: 796 YIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIAD 855
Query: 783 DPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPI 842
+P + Q L + +G + G+F + +AS L +L V R P+
Sbjct: 856 NPQLSFYQLVYGLNALLLICVGVCSS-GIFTKVTR------KASTALHNKLFNKVFRCPM 908
Query: 843 SFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP----LATV 898
SFF+ PIG LLN F+ + + +D +P L+ + ++ V L+V+V +P + +
Sbjct: 909 SFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAI 968
Query: 899 AILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ 958
++ F+ Y F+ V +RLE+ S S + SH+ + QG + + + F++Q
Sbjct: 969 IMVICFIYYMMFKKAIGV----FKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQ 1024
Query: 959 NNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAA 1018
D L + RW+A +E++ N + A A + +V+
Sbjct: 1025 FKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIV 1084
Query: 1019 LQVTQTLQWVVRNWTDLENSIVSVERMQDYA-WTPKEAPWRLPTCAAQPPWPQGGQIEFQ 1077
LQ+ + Q R + E +VER+ Y EAP + + WPQ G+I FQ
Sbjct: 1085 LQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQ 1144
Query: 1078 DFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGV 1137
D+ ++YR P + G++ I E VGIVGRTG+GKSSL L RL E G I IDGV
Sbjct: 1145 DYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV 1204
Query: 1138 PIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLP 1197
I +GL LRS++S+IPQDP+L G++R NLD H+D+ IW ALE L ++ P
Sbjct: 1205 DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFP 1264
Query: 1198 GQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWF 1257
+L + G + SVG++QLLC+ARA+LR ++I+++DEATA++D T+ +Q + F
Sbjct: 1265 KKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAF 1324
Query: 1258 AQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1303
CTVL+IAHR+ +V++C +LVM G+V E P L + G +
Sbjct: 1325 QGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1370
Score = 100 bits (250), Expect = 7e-21
Identities = 107/491 (21%), Positives = 209/491 (42%), Gaps = 32/491 (6%)
Query: 192 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 251
+A+ ++ KV +G ++N + D+++L + + + +L L +V+ +
Sbjct: 893 TALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVL 952
Query: 252 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK--- 308
+ +L P L A+ + + + + + KK + + SR+ L S IL + +
Sbjct: 953 LIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRL--ENYSRSPLFSHILNSLQGLS 1010
Query: 309 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSL----VSFQVSTFLVALVVFAVHT 364
+I +G F+ + + + L LLF S + ++ T LV L V
Sbjct: 1011 SIHVYGKTEDFISQFKRLTDAQNNYL----LLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
Query: 365 LVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFL--CLEEVDPG 422
+ + K VL + + QA + + Q + +R++ ++ C+ E
Sbjct: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQF-TAVERILQYMKMCVSEAPLH 1125
Query: 423 AVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 482
+S I Q + +P LH INLT+ ++ +VG G+GKSSL
Sbjct: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLG 1185
Query: 483 SALLGELSKVEGFVSIEGA-------------VAYVPQEAWVQNTSVVENVCFGQELDPP 529
AL + + G + I+G ++ +PQ+ + + ++ N+
Sbjct: 1186 MALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQ 1245
Query: 530 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL 589
+ LE L + FP+ +HT + E G N S G++Q L +ARAV R + + L+D+
Sbjct: 1246 QIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEAT 1305
Query: 590 AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL 649
A++D + + QG T +++ H + + D I+V+ NG + E + L
Sbjct: 1306 ASIDMETDTLIQRTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVL 1362
Query: 650 LQRKGALVCLL 660
++ G+L L
Sbjct: 1363 RKKPGSLFAAL 1373
Score = 92.4 bits (228), Expect = 2e-18
Identities = 57/216 (26%), Positives = 109/216 (50%), Gaps = 14/216 (6%)
Query: 1094 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1153
++ + G +G+ G TG+GKSSL S +L EG + + G ++
Sbjct: 530 INLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------SLAY 576
Query: 1154 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1213
+PQ + G++R N+ + + L L + LP + +RG +LS
Sbjct: 577 VPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSG 636
Query: 1214 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSV 1272
GQKQ + LARA+ QI +LD+ +AVD + + + TV+L+ H+L+ +
Sbjct: 637 GQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYL 696
Query: 1273 MDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1308
C ++++++ G++ E+G+ ++L+ +KG + +L Q+
Sbjct: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQK 732
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 568 bits (1463), Expect = e-161
Identities = 413/1366 (30%), Positives = 652/1366 (47%), Gaps = 143/1366 (10%)
Query: 7 KYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 66
++ P P A S T W++ L+ + R L + L ++S++ V RL + W
Sbjct: 79 RFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWE 138
Query: 67 RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV-FHSTFLLGTL 125
S R+G KA LR + + R + A+ + F +LG +
Sbjct: 139 EEVS------------RRGIE--KASVLLVMLRFQRT--RLIFDALLGICFCIASVLGPI 182
Query: 126 SLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKV 185
+I PK+L E +G+ G L +FLS C+++L + +
Sbjct: 183 LII---------PKILEYSEEQLGN----VVHGVGLCFALFLSECVKSLSFSSSWIINQR 229
Query: 186 LQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVW 245
+R R+A++ + K++ S S G+ ++ + DV L E V Y + +
Sbjct: 230 TAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLVLITCAS 287
Query: 246 IVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISK---KRNHHQEEQMRQKDSRARLTSS 302
+V+C + + ++G +A AI +L + PL F+++ K HH E D R R+TS
Sbjct: 288 LVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEV---SDQRIRVTSE 344
Query: 303 ILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAV 362
+L K IK + WE F + +R +E L GL+ S++ ++ + + V +
Sbjct: 345 VLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLI 404
Query: 363 HTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPG 422
HT + + + A AF L LN+L + F+P ++ L ++ + R F L+E
Sbjct: 405 HTSL-KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF-LQESPVF 462
Query: 423 AVDSSSSGSAAGKDCITIQSATFAWSQESP------------------------------ 452
V + S A + + AT +W Q P
Sbjct: 463 YVQTLQDPSKA----LVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEE 518
Query: 453 ------PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVP 506
P LH+INL V +G +L V G G+GKSSLLSA+L E+ +EG V ++G++AYVP
Sbjct: 519 EGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVP 578
Query: 507 QEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQ 566
Q+AW+ + ++ EN+ G D +VL C+L D++ P G T IGE+G+NLSGGQ
Sbjct: 579 QQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQ 638
Query: 567 KQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHIL 626
KQR+SLARAVY +YLLDDPL+A+DAHVG+H+F + I L+G T +LVTH L L
Sbjct: 639 KQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKK--TLRGKTVVLVTHQLQYL 696
Query: 627 PQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGT 686
II+L NG I E G++ EL+Q+KG L+ + + + + K P+
Sbjct: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEK-PKVE 755
Query: 687 SAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLA 746
S L + +VPE T E E G + V+
Sbjct: 756 SQALATSLEESLNGNAVPEHQLTQEEEMEE--------------------GSLSWRVYHH 795
Query: 747 YLRAVGTPLCLYALFLFLCQQV-ASFCRGYWLSLW-----------------------AD 782
Y++A G + +F F+ V + +WLS W AD
Sbjct: 796 YIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIAD 855
Query: 783 DPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPI 842
+P + Q L + +G + G+F + +AS L +L V R P+
Sbjct: 856 NPQLSFYQLVYGLNALLLICVGVCSS-GIFTKVTR------KASTALHNKLFNKVFRCPM 908
Query: 843 SFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP----LATV 898
SFF+ PIG LLN F+ + + +D +P L+ + ++ V L+V+V +P + +
Sbjct: 909 SFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAI 968
Query: 899 AILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ 958
++ F+ Y F+ V +RLE+ S S + SH+ + QG + + + F++Q
Sbjct: 969 IMVICFIYYMMFKKAIGV----FKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQ 1024
Query: 959 NNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAA 1018
D L + RW+A +E++ N + A A + +V+
Sbjct: 1025 FKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIV 1084
Query: 1019 LQVTQTLQWVVRNWTDLENSIVSVERMQDYA-WTPKEAPWRLPTCAAQPPWPQGGQIEFQ 1077
LQ+ + Q R + E +VER+ Y EAP + + WPQ G+I FQ
Sbjct: 1085 LQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQ 1144
Query: 1078 DFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGV 1137
D+ ++YR P + G++ I E VGIVGRTG+GKSSL L RL E G I IDGV
Sbjct: 1145 DYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV 1204
Query: 1138 PIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLP 1197
I +GL LRS++S+IPQDP+L G++R NLD H+D+ IW ALE L ++ P
Sbjct: 1205 DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFP 1264
Query: 1198 GQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWF 1257
+L + G + SVG++QLLC+ARA+LR ++I+++DEATA++D T+ +Q + F
Sbjct: 1265 KKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAF 1324
Query: 1258 AQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1303
CTVL+IAHR+ +V++C +LVM G+V E P L + G +
Sbjct: 1325 QGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1370
Score = 100 bits (250), Expect = 7e-21
Identities = 107/491 (21%), Positives = 209/491 (42%), Gaps = 32/491 (6%)
Query: 192 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 251
+A+ ++ KV +G ++N + D+++L + + + +L L +V+ +
Sbjct: 893 TALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVL 952
Query: 252 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK--- 308
+ +L P L A+ + + + + + KK + + SR+ L S IL + +
Sbjct: 953 LIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRL--ENYSRSPLFSHILNSLQGLS 1010
Query: 309 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSL----VSFQVSTFLVALVVFAVHT 364
+I +G F+ + + + L LLF S + ++ T LV L V
Sbjct: 1011 SIHVYGKTEDFISQFKRLTDAQNNYL----LLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
Query: 365 LVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFL--CLEEVDPG 422
+ + K VL + + QA + + Q + +R++ ++ C+ E
Sbjct: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQF-TAVERILQYMKMCVSEAPLH 1125
Query: 423 AVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 482
+S I Q + +P LH INLT+ ++ +VG G+GKSSL
Sbjct: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLG 1185
Query: 483 SALLGELSKVEGFVSIEGA-------------VAYVPQEAWVQNTSVVENVCFGQELDPP 529
AL + + G + I+G ++ +PQ+ + + ++ N+
Sbjct: 1186 MALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQ 1245
Query: 530 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL 589
+ LE L + FP+ +HT + E G N S G++Q L +ARAV R + + L+D+
Sbjct: 1246 QIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEAT 1305
Query: 590 AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL 649
A++D + + QG T +++ H + + D I+V+ NG + E + L
Sbjct: 1306 ASIDMETDTLIQRTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVL 1362
Query: 650 LQRKGALVCLL 660
++ G+L L
Sbjct: 1363 RKKPGSLFAAL 1373
Score = 92.4 bits (228), Expect = 2e-18
Identities = 57/216 (26%), Positives = 109/216 (50%), Gaps = 14/216 (6%)
Query: 1094 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1153
++ + G +G+ G TG+GKSSL S +L EG + + G ++
Sbjct: 530 INLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------SLAY 576
Query: 1154 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1213
+PQ + G++R N+ + + L L + LP + +RG +LS
Sbjct: 577 VPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSG 636
Query: 1214 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSV 1272
GQKQ + LARA+ QI +LD+ +AVD + + + TV+L+ H+L+ +
Sbjct: 637 GQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYL 696
Query: 1273 MDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1308
C ++++++ G++ E+G+ ++L+ +KG + +L Q+
Sbjct: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQK 732
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 530 bits (1366), Expect = e-150
Identities = 317/864 (36%), Positives = 479/864 (55%), Gaps = 46/864 (5%)
Query: 455 LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNT 514
LH I+L + +G L+ + G VG+GK+SL+SA+LG+++ +EG ++I G AYV Q+AW+ N
Sbjct: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNA 637
Query: 515 SVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLAR 574
++ +N+ FG+E D VL +C L+PD+ P T IGE+G NLSGGQ+QR+SLAR
Sbjct: 638 TLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLAR 697
Query: 575 AVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIV 634
A+Y ++Y+LDDPL+ALDAHVG H+FN I L+ T + VTH L L D +I
Sbjct: 698 ALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKH--LKSKTVLFVTHQLQYLVDCDEVIF 755
Query: 635 LANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPEL 694
+ G I E G+++EL+ G + + GET P + TS ++
Sbjct: 756 MKEGCITERGTHEELMNLNGDYATIFNNLLL------GETPP-VEINSKKETSGSQKKSQ 808
Query: 695 RRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTP 754
+ SV ++ E V L++ + G V +V+ Y++A G P
Sbjct: 809 DKGPKTGSVKKEKAVKPEEGQLVQLEEKGQ------------GSVPWSVYGVYIQAAGGP 856
Query: 755 LC-LYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQA----- 808
L L + LF+ ++ +WLS W G RG + ++
Sbjct: 857 LAFLVIMALFMLNVGSTAFSTWWLSYWIKQ----GSGNTTVTRGNETSVSDSMKDNPHMQ 912
Query: 809 --IGLFASMAAVLL------------GGARASRLLFQRLLWDVVRSPISFFERTPIGHLL 854
++A AV+L G RAS L L ++RSP+ FF+ TP G +L
Sbjct: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
Query: 855 NRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLY 914
NRFSK+ D VDV +P + + + ++A P VA+ PL +L++ +
Sbjct: 973 NRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVS 1032
Query: 915 VVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRL 974
V +L+RL++ + S SH+ + QG + A+ F+ + +D++Q F
Sbjct: 1033 RVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFT 1092
Query: 975 VADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTD 1034
A RWLA ++L+ L+ VL + G ++S A+Q+T Q+ VR ++
Sbjct: 1093 CAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASE 1152
Query: 1035 LENSIVSVERMQDYAWTPK-EAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQG 1093
E SVER+ Y T EAP R+ A P WPQ G++ F++ +RYR LPL ++
Sbjct: 1153 TEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKK 1212
Query: 1094 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1153
VSF I EK+GIVGRTG+GKSSL L RL E + G I IDGV I+ +GL LRS++SI
Sbjct: 1213 VSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSI 1272
Query: 1154 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1213
IPQ+P+LF G++R NLD +++++ IW ALE +K +A LP +L+ + + G++ SV
Sbjct: 1273 IPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSV 1332
Query: 1214 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVM 1273
G++QLLC+ARALLR +ILILDEATAA+D T+L +Q + FA CT+L IAHRL +V+
Sbjct: 1333 GERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVL 1392
Query: 1274 DCARVLVMDKGQVAESGSPAQLLA 1297
R++V+ +GQV E +P+ LL+
Sbjct: 1393 GSDRIMVLAQGQVVEFDTPSVLLS 1416
Score = 120 bits (301), Expect = 9e-27
Identities = 106/437 (24%), Positives = 191/437 (43%), Gaps = 39/437 (8%)
Query: 13 PETGAAFPSKATFWWVSGLVWRGYRR-PLRPKDLWSLGRENSSEELVSRLEKEWMRNRSA 71
P A S TF W+S L +++ L +D+WSL + SS+ RLE+ W
Sbjct: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE--- 156
Query: 72 ARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISD 131
L + G L + +W + +L + L+I+
Sbjct: 157 --------------------------LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQ 190
Query: 132 VFRFTVPK-LLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRL 190
+ F+ P ++ LE+ + LL + + L+ +++ +RL
Sbjct: 191 LAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRL 250
Query: 191 RSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCF 250
R AI + ++K+L L + K+ +G+++N+ S D QR+ E+ + L V ++
Sbjct: 251 RGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGM 308
Query: 251 VYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTI 310
+Y +LGP+ AVF+ P F S+ + + + + D R + + +L K I
Sbjct: 309 IYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFI 368
Query: 311 KFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENA 370
K + W AF V IR +E L +G S+++ + + ++V F+VH + +
Sbjct: 369 KMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFD- 427
Query: 371 MNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGAVDSSSSG 430
+ A +AF +TV N + A PFS+ SL +A V+ DR + +EE V +
Sbjct: 428 LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEE-----VHMIKNK 482
Query: 431 SAAGKDCITIQSATFAW 447
A+ I +++AT AW
Sbjct: 483 PASPHIKIEMKNATLAW 499
Score = 89.7 bits (221), Expect = 2e-17
Identities = 63/216 (29%), Positives = 104/216 (48%), Gaps = 16/216 (7%)
Query: 1087 LPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHT 1146
L + + +I G+ VGI G G+GK+SL S +L EG I I G
Sbjct: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT--------- 624
Query: 1147 LRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCAD 1206
+ + Q + +LR N+ +E+ +E + L + L+ +A LP + +
Sbjct: 625 ----FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
Query: 1207 RGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDP--GTELQMQAMLGSWFAQCTVLL 1264
RG +LS GQ+Q + LARAL I ILD+ +A+D G + + + TVL
Sbjct: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHI-FNSAIRKHLKSKTVLF 739
Query: 1265 IAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKG 1300
+ H+L+ ++DC V+ M +G + E G+ +L+ G
Sbjct: 740 VTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
Score = 75.1 bits (183), Expect = 4e-13
Identities = 58/226 (25%), Positives = 105/226 (46%), Gaps = 16/226 (7%)
Query: 438 ITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSAL--LGELS----K 491
+T ++A + + P L +++ T+ + +VG G+GKSSL AL L ELS K
Sbjct: 1193 VTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIK 1252
Query: 492 VE-------GFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDV 544
++ G + ++ +PQE + + +V N+ + + LE ++ +
Sbjct: 1253 IDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECI 1312
Query: 545 DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 604
P + + + E G N S G++Q L +ARA+ R + +LD+ AA+D + +
Sbjct: 1313 AQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETI 1372
Query: 605 IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELL 650
T + + H LH + +D I+VLA G + E + LL
Sbjct: 1373 ---REAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL 1415
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 518 bits (1335), Expect = e-146
Identities = 399/1366 (29%), Positives = 628/1366 (45%), Gaps = 181/1366 (13%)
Query: 7 KYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 66
++ P P A S T W++ L+ + R L + L ++S++ V RL + W
Sbjct: 79 RFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWE 138
Query: 67 RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV-FHSTFLLGTL 125
S R+G KA LR + + R + A+ + F +LG +
Sbjct: 139 EEVS------------RRGIE--KASVLLVMLRFQRT--RLIFDALLGICFCIASVLGPI 182
Query: 126 SLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKV 185
+I PK+L E +G+ G L +FLS C+++L + +
Sbjct: 183 LII---------PKILEYSEEQLGN----VVHGVGLCFALFLSECVKSLSFSSSWIINQR 229
Query: 186 LQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVW 245
+R R+A++ + K++ S S G+ ++ + DV L E V Y + +
Sbjct: 230 TAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLVLITCAS 287
Query: 246 IVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISK---KRNHHQEEQMRQKDSRARLTSS 302
+V+C + + ++G +A AI +L + PL F+++ K HH E D R R+TS
Sbjct: 288 LVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEV---SDQRIRVTSE 344
Query: 303 ILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAV 362
+L K IK + WE F + +R +E L GL+ S++ ++ + + V +
Sbjct: 345 VLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLI 404
Query: 363 HTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPG 422
HT + + + A AF L LN+L + F+P ++ L ++ + R F L+E
Sbjct: 405 HTSL-KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF-LQESPVF 462
Query: 423 AVDSSSSGSAAGKDCITIQSATFAWSQESP------------------------------ 452
V + S A + + AT +W Q P
Sbjct: 463 YVQTLQDPSKA----LVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEE 518
Query: 453 ------PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVP 506
P LH+INL V +G +L V G G+GKSSLLSA+L E+ +EG V ++G++AYVP
Sbjct: 519 EGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVP 578
Query: 507 QEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQ 566
Q+AW+ + ++ EN+ G D +VL C+L D++ P G T IGE+G+NLSGGQ
Sbjct: 579 QQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQ 638
Query: 567 KQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHIL 626
KQR+SLARAVY +YLLDDPL+A+DAHVG+H+F + I L+G T +LVTH L L
Sbjct: 639 KQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKK--TLRGKTVVLVTHQLQYL 696
Query: 627 PQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGT 686
II+L NG I E G++ EL+Q+KG L+ + + + + + P+
Sbjct: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA-TSDMLQDTAKIAEKPKVE 755
Query: 687 SAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLA 746
S L + +VPE T E E G + V+
Sbjct: 756 SQALATSLEESLNGNAVPEHQLTQEEEMEE--------------------GSLSWRVYHH 795
Query: 747 YLRAVGTPLCLYALFLFLCQQV-ASFCRGYWLSLW-----------------------AD 782
Y++A G + +F F+ V + +WLS W AD
Sbjct: 796 YIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIAD 855
Query: 783 DPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPI 842
+P + Q L + +G + G+F + +AS L +L V R P+
Sbjct: 856 NPQLSFYQLVYGLNALLLICVGVCSS-GIFTKVT------RKASTALHNKLFNKVFRCPM 908
Query: 843 SFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP----LATV 898
SFF+ PIG LLN F+ + + +D +P L+ + ++ V L+V+V +P + +
Sbjct: 909 SFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAI 968
Query: 899 AILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ 958
++ F+ Y F+ V +RLE+ S S + SH+ + QG + + + F++Q
Sbjct: 969 IMVICFIYYMMFKKAIGV----FKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQ 1024
Query: 959 NNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAA 1018
D L + RW+A +E++ N + A A + +V+
Sbjct: 1025 FKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIV 1084
Query: 1019 LQVTQTLQWVVRNWTDLENSIVSVERMQDY-AWTPKEAPWRLPTCAAQPPWPQGGQIEFQ 1077
LQ+ + Q R + E +VER+ Y EAP + + WPQ G+I FQ
Sbjct: 1085 LQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQ 1144
Query: 1078 DFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGV 1137
D+ ++YR P + G++ I E VGIVGRTG+GKSSL L RL E G I IDGV
Sbjct: 1145 DYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV 1204
Query: 1138 PIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLP 1197
I +GL LRS++S+IPQDP+L G++R NLD H+D+ IW ALE
Sbjct: 1205 DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE------------ 1252
Query: 1198 GQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWF 1257
R L K I+++DEATA++D T+ +Q + F
Sbjct: 1253 -------------------------RTFLTKA-IILIDEATASIDMETDTLIQRTIREAF 1286
Query: 1258 AQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1303
CTVL+IAHR+ +V++C +LVM G+V E P L + G +
Sbjct: 1287 QGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
Score = 92.4 bits (228), Expect = 2e-18
Identities = 57/216 (26%), Positives = 109/216 (50%), Gaps = 14/216 (6%)
Query: 1094 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1153
++ + G +G+ G TG+GKSSL S +L EG + + G ++
Sbjct: 530 INLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------SLAY 576
Query: 1154 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1213
+PQ + G++R N+ + + L L + LP + +RG +LS
Sbjct: 577 VPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSG 636
Query: 1214 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSV 1272
GQKQ + LARA+ QI +LD+ +AVD + + + TV+L+ H+L+ +
Sbjct: 637 GQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYL 696
Query: 1273 MDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1308
C ++++++ G++ E+G+ ++L+ +KG + +L Q+
Sbjct: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQK 732
Score = 64.3 bits (155), Expect = 7e-10
Identities = 99/479 (20%), Positives = 193/479 (40%), Gaps = 46/479 (9%)
Query: 192 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 251
+A+ ++ KV +G ++N + D+++L + + + +L L +V+ +
Sbjct: 893 TALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVL 952
Query: 252 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK--- 308
+ +L P L A+ + + + + + KK + + SR+ L S IL + +
Sbjct: 953 LIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRL--ENYSRSPLFSHILNSLQGLS 1010
Query: 309 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSL----VSFQVSTFLVALVVFAVHT 364
+I +G F+ + + + L LLF S + ++ T LV L V
Sbjct: 1011 SIHVYGKTEDFISQFKRLTDAQNNYL----LLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
Query: 365 LVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFL--CLEEVDPG 422
+ + K VL + + QA + + Q + +R++ ++ C+ E
Sbjct: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQF-TAVERILQYMKMCVSEAPLH 1125
Query: 423 AVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 482
+S I Q + +P LH INLT+ ++ +VG G+GKSSL
Sbjct: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLG 1185
Query: 483 SALLGELSKVEGFVSIEGA-VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 541
AL + + G + I+G + + E SV+ DP VL + ++
Sbjct: 1186 MALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQ-------DP-----VLLSGTIR 1233
Query: 542 PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF 601
++D F I + +L R KA + L+D+ A++D +
Sbjct: 1234 FNLDPFDRHTDQQIWD-------------ALERTFLTKAII-LIDEATASIDMETDTLIQ 1279
Query: 602 NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL 660
+ QG T +++ H + + D I+V+ NG + E + L ++ G+L L
Sbjct: 1280 RTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 362 bits (928), Expect = 2e-99
Identities = 261/882 (29%), Positives = 432/882 (48%), Gaps = 77/882 (8%)
Query: 11 PCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRS 70
P P A S+ FWW++ L G++R L D++S+ E+ S+ L L+ W ++
Sbjct: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFW--DKE 67
Query: 71 AARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLI-- 128
R N A Q+ S R ++K W+ S +LG +LI
Sbjct: 68 VLRAENDA---------------------QKPSLTRAIIKCYWK---SYLVLGIFTLIEE 103
Query: 129 ----ISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLK 184
I +F + K+++ F + Y A ++ + + Y ++
Sbjct: 104 SAKVIQPIF---LGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
Query: 185 VLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLV 244
MRLR A+ ++YRK L LS+ + + G +VNL+S DV + + ++L+ LW +
Sbjct: 161 CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL 220
Query: 245 WIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSIL 304
+ LW +G S L +AV + LLPL K + + + D+R R + ++
Sbjct: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
Query: 305 RNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHT 364
+ IK + WE +F + + +R +E+ + S L ++L SF ++ ++ V F +
Sbjct: 281 TGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYV 340
Query: 365 LVAENAMNAEKAFVTLTVLNILN-KAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGA 423
L+ + + A + FV +T+ + F P +I + +A VS R+ TFL L+E+
Sbjct: 341 LLG-SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRN 399
Query: 424 VDSSSSGSAAGKDCITIQSATFAWSQESP-PCLHRINLTVPQGCLLAVVGPVGAGKSSLL 482
S G K + +Q T W + S P L ++ TV G LLAVVGPVGAGKSSLL
Sbjct: 400 RQLPSDG----KKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLL 455
Query: 483 SALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQP 542
SA+LGEL+ G VS+ G +AYV Q+ WV + ++ N+ FG++ + E+V++ACAL+
Sbjct: 456 SAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKK 515
Query: 543 DVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFN 602
D+ +G T IG++G LSGGQK R++LARAVY+ A +YLLDDPL+A+DA V +H+F
Sbjct: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
Query: 603 QVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQ 662
I +L ILVTH L L A I++L +G + + G+Y E L+ LL
Sbjct: 576 LCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL-- 631
Query: 663 ARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDP 722
++ + E PGT P LR +S +++ + + L+
Sbjct: 632 -KKDNEESEQPPVPGT-------------PTLRNRTFSESSVWSQQSSRPSLKDGALESQ 677
Query: 723 DRAGWPA--GKDSIQYGRVKATVHLAYLRA-VGTPLCLYALFLFLCQQVASFCRGYWLSL 779
D P +++ G+V + Y RA + ++ + L QVA + +WLS
Sbjct: 678 DTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSY 737
Query: 780 WADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFA--SMAAVLLGGAR----------ASR 827
WA+ ++ G + L +G+++ ++A VL G AR +S+
Sbjct: 738 WANKQSMLNVTVNGG--GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQ 795
Query: 828 LLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIP 869
L ++ ++++P+ FF+R PIG +LNRFSK+ +D +P
Sbjct: 796 TLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLP 837
Score = 90.9 bits (224), Expect = 7e-18
Identities = 105/456 (23%), Positives = 197/456 (43%), Gaps = 28/456 (6%)
Query: 847 RTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLL 906
+T G ++N S + + D + L L + V+ ++ + ++ +A + + ++
Sbjct: 188 KTTTGQIVNLLSNDVNKFD-QVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLII 246
Query: 907 YAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ-NNARVDE 965
QS + LR + + M E G +++ + + F N R E
Sbjct: 247 LLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKE 306
Query: 966 SQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVS--AALQVTQ 1023
+I + LA+ +VF T VL + ++A V +V+ A+++T
Sbjct: 307 ISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTV 365
Query: 1024 TLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFQDFGLRY 1083
TL + + +IVS+ R+Q + + + Q P + QDF +
Sbjct: 366 TL-FFPSAIERVSEAIVSIRRIQTFLLLDE-----ISQRNRQLPSDGKKMVHVQDFTAFW 419
Query: 1084 --RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAH 1141
E P +QG+SF + GE + +VG GAGKSSL S +L G
Sbjct: 420 DKASETP-TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVL-------------GELAPS 465
Query: 1142 VGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQ 1201
GL ++ RI+ + Q P +F G+LR N+ +++ E ++ LK + L
Sbjct: 466 HGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDL 525
Query: 1202 YKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQC 1260
DRG LS GQK + LARA+ + I +LD+ +AVD + + + +
Sbjct: 526 TVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEK 585
Query: 1261 TVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLL 1296
+L+ H+L+ + +++L++ G++ + G+ + L
Sbjct: 586 ITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFL 621
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 252 bits (643), Expect = 2e-66
Identities = 163/533 (30%), Positives = 272/533 (51%), Gaps = 27/533 (5%)
Query: 801 GLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKE 860
G+ L A+G F + V S++L ++L V+++P+S G +LNRFSK+
Sbjct: 921 GVADTLLAMGFFRGLPLVHTL-ITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKD 979
Query: 861 TDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQ 920
+D +P + + ++ VVAV P VA +P+ + + ++ ++ +S Q
Sbjct: 980 IAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQ 1039
Query: 921 LRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWL 980
L++LES S + +H+ + +G +RAF Q F + ++ F L RW
Sbjct: 1040 LKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWF 1099
Query: 981 AANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIV 1040
+E++ A ++L+ G VG ++ A+ + TLQW V + D+++ +
Sbjct: 1100 QMRIEMIFVIFFIAVTFISILTTGE-GEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMR 1158
Query: 1041 SVERMQDYAWTPKEAPWRLPTCAAQPP---------------------WPQGGQIEFQDF 1079
SV R+ + P E PT + +P WP GGQ+ +D
Sbjct: 1159 SVSRVFKFIDMPTEGK---PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDL 1215
Query: 1080 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1139
+Y ++ +SF I G++VG++GRTG+GKS+L S LRL EG I IDGV
Sbjct: 1216 TAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVSW 1274
Query: 1140 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQ 1199
+ L R +IPQ +F G+ R NLD ++ SD+ IW + V L++++ PG+
Sbjct: 1275 DSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGK 1334
Query: 1200 LQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQ 1259
L + D G LS G KQL+CLAR++L K +IL+LDE +A +DP T ++ L FA
Sbjct: 1335 LDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFAD 1394
Query: 1260 CTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1312
CTV+L HR+ ++++C + LV+++ +V + S +LL ++ LF + S V
Sbjct: 1395 CTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRV 1447
Score = 220 bits (560), Expect = 8e-57
Identities = 166/671 (24%), Positives = 308/671 (45%), Gaps = 76/671 (11%)
Query: 13 PETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAA 72
P A+ SK F W ++ +GYR+ L D++ + +S++ L +LE+EW R A+
Sbjct: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDREL-AS 63
Query: 73 RRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDV 132
+++ K L+ A+ + F F+ + L + +V
Sbjct: 64 KKNPK------------------------------LINALRRCFFWRFMFYGIFLYLGEV 93
Query: 133 FRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACL----QTLFEQQNMYRLKVLQM 188
+ P LL I P + +A+ + + CL +TL ++ L + M
Sbjct: 94 TKAVQPLLLG---RIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGM 150
Query: 189 RLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVV 248
++R A+ L+Y+K L LSS ++G +V+L+S ++ + E + + +W+ + + +
Sbjct: 151 QMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVAL 210
Query: 249 CFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK 308
+W+LL SA + + L + + +++++ + R +TS ++ N +
Sbjct: 211 LMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQ 270
Query: 309 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAE 368
++K + WE A + +R EL R + + + +F S F V + + L+
Sbjct: 271 SVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALI-- 328
Query: 369 NAMNAEKAFVTLTVLNILNKAQAF-LPFSIHSLVQARVSFDRLVTFLCLEEV-------- 419
+ K F T++ +L A P+++ + + + +++ FL +E
Sbjct: 329 KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLT 388
Query: 420 ---------------------DPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRI 458
+ ++++ ++ G D + + +S P L I
Sbjct: 389 TTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSN----FSLLGTPVLKDI 444
Query: 459 NLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVE 518
N + +G LLAV G GAGK+SLL ++GEL EG + G +++ Q +W+ ++ E
Sbjct: 445 NFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKE 504
Query: 519 NVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYR 578
N+ FG D V++AC L+ D+ F E + +GE G+ LSGGQ+ R+SLARAVY+
Sbjct: 505 NIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYK 564
Query: 579 KAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANG 638
A +YLLD P LD + +F + L+ TRILVT + L +AD I++L G
Sbjct: 565 DADLYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKKADKILILHEG 622
Query: 639 AIAEMGSYQEL 649
+ G++ EL
Sbjct: 623 SSYFYGTFSEL 633
Score = 80.1 bits (196), Expect = 1e-14
Identities = 63/245 (25%), Positives = 114/245 (46%), Gaps = 21/245 (8%)
Query: 438 ITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS 497
+T++ T +++ L I+ ++ G + ++G G+GKS+LLSA L L EG +
Sbjct: 1210 MTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQ 1268
Query: 498 IEG-------------AVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDV 544
I+G A +PQ+ ++ + + +N+ ++ + +V + L+ +
Sbjct: 1269 IDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVI 1328
Query: 545 DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 604
+ FP + + + G LS G KQ + LAR+V KA + LLD+P A LD V + +
Sbjct: 1329 EQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRT 1387
Query: 605 IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQAR 664
+ T IL H + + + +V+ + + S Q+LL + L QA
Sbjct: 1388 LKQA--FADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS----LFRQAI 1441
Query: 665 QPGDR 669
P DR
Sbjct: 1442 SPSDR 1446
Score = 70.5 bits (171), Expect = 1e-11
Identities = 68/314 (21%), Positives = 133/314 (42%), Gaps = 49/314 (15%)
Query: 1011 VGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTP--KEAPWRLPTCAAQPP- 1067
+ F + + VT+ W V+ W D S+ ++ ++QD+ K + L T
Sbjct: 340 ISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQEYKTLEYNLTTTEVVMEN 396
Query: 1068 ----WPQG---------------------GQIEFQDFGLRYRPELPLAVQGVSFKIHAGE 1102
W +G + F +F L P L + ++FKI G+
Sbjct: 397 VTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVL----KDINFKIERGQ 452
Query: 1103 KVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFP 1162
+ + G TGAGK+SL ++ E +EG I H G RIS Q + P
Sbjct: 453 LLAVAGSTGAGKTSLLMVIMGELEPSEG-------KIKHSG------RISFCSQFSWIMP 499
Query: 1163 GSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLA 1222
G+++ N+ + + + ++ QL+ ++ + + G LS GQ+ + LA
Sbjct: 500 GTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLA 559
Query: 1223 RALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSVMDCARVLVM 1281
RA+ + + +LD +D TE ++ ++ + A T +L+ ++ + ++L++
Sbjct: 560 RAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILIL 619
Query: 1282 DKGQVAESGSPAQL 1295
+G G+ ++L
Sbjct: 620 HEGSSYFYGTFSEL 633
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 250 bits (639), Expect = 5e-66
Identities = 139/349 (39%), Positives = 202/349 (57%), Gaps = 6/349 (1%)
Query: 10 NPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNR 69
NP PET A F S+ FWW + + GYR PL KDLWSL E+ S+ +V +L + W +
Sbjct: 205 NPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQE 264
Query: 70 SAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRP-LLKAIWQVFHSTFLLGTLSLI 128
RH KA A K SG E E L +P LKA+ F S+FL+ +
Sbjct: 265 KQTARH-KASAAPGKNASG----EDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKL 319
Query: 129 ISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQM 188
I D+ F P+LLS+ + FI +P P+W G+L+A LMFL + +Q+L Q + + V +
Sbjct: 320 IQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGV 379
Query: 189 RLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVV 248
+ R+ I G++YRK L +++ ++AS VG++VNL+SVD QR + +LN LW + I++
Sbjct: 380 KFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIIL 439
Query: 249 CFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK 308
+LWQ LGPS L +A + L+PLN ++ K Q +QM+ KDSR +L S IL K
Sbjct: 440 AIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIK 499
Query: 309 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVAL 357
+K + WE +FL +V GIR EL LRT+ L + + ++ S FLV L
Sbjct: 500 VLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVRL 548
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 228 bits (581), Expect = 3e-59
Identities = 238/911 (26%), Positives = 403/911 (44%), Gaps = 96/911 (10%)
Query: 448 SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------ 501
S++ L +NL V G +A+VG G GKS+ + + EG VS++G
Sbjct: 403 SRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTIN 462
Query: 502 -------VAYVPQEAWVQNTSVVENVCFGQE-LDPPWLERVLEACALQPDVDSFPEGIHT 553
+ V QE + T++ EN+ +G+E + +E+ ++ + P T
Sbjct: 463 VRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDT 522
Query: 554 SIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQG 613
+GE+G LSGGQKQR+++ARA+ R + LLD+ +ALD V + +G
Sbjct: 523 LVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV---QVALDKARKG 579
Query: 614 TTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLD--------QARQ 665
T I++ H L + AD I +G I E G++ EL++ KG L+ +
Sbjct: 580 RTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELEN 639
Query: 666 PGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDD--PD 723
D + E + + + +S R+ RR S++ +DR S T+ LD+ P
Sbjct: 640 AADESKSEIDALEMSSNDSRSSLIRKRSTRR--SVRGSQAQDRKLS---TKEALDESIPP 694
Query: 724 RAGWPAGKDSI-QYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWAD 782
+ W K ++ ++ V A + P A + + + F R D
Sbjct: 695 VSFWRIMKLNLTEWPYFVVGVFCAIINGGLQP----AFAIIFSKIIGVFTR-------ID 743
Query: 783 DPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGA--RASRLLFQRLLWDVVRS 840
DP Q + +F LL A+G+ + + L G +A +L +RL + V RS
Sbjct: 744 DPETKRQNSN------LFSLL--FLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRS 795
Query: 841 ----PISFFE--RTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGL---LEVSLVVAV 891
+S+F+ + G L R + + V I +L + L + +S +
Sbjct: 796 MLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGW 855
Query: 892 ATPLATVAILPLFLLYAGFQSLYVVSSCQLR-RLESASYSSVCSHMAETFQGSTVVR--- 947
L +AI+P+ + AG + ++S L+ + E + + E F+ TVV
Sbjct: 856 QLTLLLLAIVPIIAI-AGVVEMKMLSGQALKDKKELEGSGKIATEAIENFR--TVVSLTQ 912
Query: 948 --------AFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCA 999
A Q P+ +N+ R I+F A + + G A
Sbjct: 913 EQKFEHMYAQSLQVPY--RNSLRKAHIFGITFSFTQAMMYFSY-AGCFRFGAYLVAHKLM 969
Query: 1000 VLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRL 1059
L V F A QV+ + + I+ +E+ TP +
Sbjct: 970 SFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEK------TPLIDSY-- 1021
Query: 1060 PTCAAQPPWPQGGQIEFQDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSL 1117
+ P G + F + Y RP++P+ +QG+S ++ G+ + +VG +G GKS++
Sbjct: 1022 -STEGLMPNTLEGNVTFGEVVFNYPTRPDIPV-LQGLSLEVKKGQTLALVGSSGCGKSTV 1079
Query: 1118 ASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQE 1174
L R + G + +DG I + + LR+ + I+ Q+PILF S+ N+ D +
Sbjct: 1080 VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1139
Query: 1175 HSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILIL 1234
S E I A + + A + SLP + K D+G LS GQKQ + +ARAL+R+ IL+L
Sbjct: 1140 VSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLL 1199
Query: 1235 DEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQ 1294
DEAT+A+D +E +Q L T ++IAHRL ++ + ++V G+V E G+ Q
Sbjct: 1200 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQ 1259
Query: 1295 LLAQKGLFYRL 1305
LLAQKG+++ +
Sbjct: 1260 LLAQKGIYFSM 1270
Score = 140 bits (354), Expect = 6e-33
Identities = 125/516 (24%), Positives = 237/516 (45%), Gaps = 24/516 (4%)
Query: 803 LGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD 862
+G + + ++ L R + ++ ++R I +F+ +G L R + +
Sbjct: 121 IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS 180
Query: 863 TVDVDIPDKL----RSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 918
++ I DK+ +S+ + G + V L +AI P+ L A + + S
Sbjct: 181 KINEGIGDKIGMFFQSMATFFTGFI-VGFTRGWKLTLVILAISPVLGLSAAVWAKILSSF 239
Query: 919 CQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADR 978
L A +V E V AF Q + + N ++E++RI + +
Sbjct: 240 TDKELLAYAKAGAVAE---EVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAIT-- 294
Query: 979 WLAANVELLGNGLVFAAATCAVLSKAHLSAGLVG-FSVSAALQVTQTLQWVVRNWTDLEN 1037
AN+ + G + A+ A+ + L G +S+ L V ++ +
Sbjct: 295 ---ANISI-GAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASP 350
Query: 1038 SIVSVERMQDYAWTPKEAPWRLPTC-----AAQPPWPQGGQIEFQDFGLRY--RPELPLA 1090
SI + + A+ + P+ + P G +EF++ Y R E+ +
Sbjct: 351 SIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKI- 409
Query: 1091 VQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSR 1150
++G++ K+ +G+ V +VG +G GKS+ + RL + EG + +DG I + + LR
Sbjct: 410 LKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREI 469
Query: 1151 ISIIPQDPILFPGSLRMNLDLLQEH-SDEAIWAALETVQLKALVASLPGQLQYKCADRGE 1209
I ++ Q+P+LF ++ N+ +E+ + + I A++ + LP + +RG
Sbjct: 470 IGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGA 529
Query: 1210 DLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRL 1269
LS GQKQ + +ARAL+R +IL+LDEAT+A+D +E +Q L T ++IAHRL
Sbjct: 530 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRL 589
Query: 1270 RSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1305
+V + + D G + E G+ +L+ +KG++++L
Sbjct: 590 STVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 219 bits (557), Expect = 2e-56
Identities = 282/1207 (23%), Positives = 509/1207 (42%), Gaps = 172/1207 (14%)
Query: 199 YRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYL----- 253
+R+++ + G ++VG++ S D+ ++ +++ L++ + +C L
Sbjct: 179 FRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRG 238
Query: 254 WQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFH 313
W+L + + + + +SK ++ +++ + ++ + +T+
Sbjct: 239 WKLTLVIISVSPLIGIGAATIGLSVSKFTDY----ELKAYAKAGVVADEVISSMRTVAAF 294
Query: 314 GWEGAFLDRVLG--IRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAM 371
G E ++R + Q G + + F V + + AL + TLV +
Sbjct: 295 GGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFV-WCLIFLCYALAFWYGSTLVLDEGE 353
Query: 372 NAEKAFVTLTV------LNILNKAQAFLPFSIHSLVQARV--SFDRLVTFLCLEEVDPGA 423
V + + LN+ N + F+ + + DR C+ E
Sbjct: 354 YTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSE----- 408
Query: 424 VDSSSSGSAAGKDCITIQSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 482
D G+ I + TF + S+ L+ +N+ + G + A+VGP GAGKS+ L
Sbjct: 409 -DGYKLDRIKGE--IEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTAL 465
Query: 483 SALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFGQELDPP 529
+ EG V+++G + V QE + +T++ EN+ +G+E
Sbjct: 466 QLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGRE--DA 523
Query: 530 WLERVLEACALQPDVDSF----PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLL 585
+E +++A A + + +F P+ T +GE G +SGGQKQR+++ARA+ R + LL
Sbjct: 524 TMEDIVQA-AKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLL 582
Query: 586 DDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGS 645
D +ALD + + + +V+ + G T I V H L + AD II +G E G+
Sbjct: 583 DMATSALD-NESEAMVQEVLSK--IQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGT 639
Query: 646 YQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDP-------RGTSAGRRPELRRER 698
++ELL+RKG L+ Q G++ E + +T+D RG+ R+R
Sbjct: 640 HEELLERKGVYFTLVTLQSQ-GNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQR 698
Query: 699 SI-----------------KSVPEKDRTTSEAQTEVPLDDP--------DRAGWPAGKDS 733
S KS E+DR + + ++ WP
Sbjct: 699 SKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPY---- 754
Query: 734 IQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQA 793
+ G V A V+ GT LYA FLF Q + +F ++ ++ Q
Sbjct: 755 MLVGSVGAAVN-------GTVTPLYA-FLF-SQILGTF-------------SIPDKEEQR 792
Query: 794 ALRGGI---FGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFE--RT 848
+ G+ F +GC+ F A G ++ L + ++ I++F+ R
Sbjct: 793 SQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRN 852
Query: 849 PIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVA----TPLATVAILPLF 904
G L R + + V ++ +++ +F + V++++A + L + P F
Sbjct: 853 SPGALTTRLATDASQVQGAAGSQI-GMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFP-F 910
Query: 905 LLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVD 964
L +G +++ R + + V E V + F+ ++
Sbjct: 911 LALSGATQTRMLTGFASR--DKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELE 968
Query: 965 ESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAA----LQ 1020
+ + + + AN+ G FA A C + S G+ +S
Sbjct: 969 KPFKTAIQK--------ANIY----GFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSY 1016
Query: 1021 VTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCA------AQPP------- 1067
V + + VV + T L + +++TP A ++ QPP
Sbjct: 1017 VFRVISAVVLSATALGRA---------FSYTPSYAKAKISAARFFQLLDRQPPISVYNTA 1067
Query: 1068 ---WPQ-GGQIEFQDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGL 1121
W G+I+F D Y RP+ + + G+S I G+ + VG +G GKS+ L
Sbjct: 1068 GEKWDNFQGKIDFVDCKFTYPSRPDSQV-LNGLSVSISPGQTLAFVGSSGCGKSTSIQLL 1126
Query: 1122 LRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDE 1178
R + +G + IDG V + LRS I I+ Q+P+LF S+ N+ D +E E
Sbjct: 1127 ERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPME 1186
Query: 1179 AIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEAT 1238
+ AA + QL V SLP + + +G LS G+KQ + +ARA++R +IL+LDEAT
Sbjct: 1187 RVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEAT 1246
Query: 1239 AAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQ 1298
+A+D +E +Q L T ++IAHRL ++ + + VM +G V E G+ +L+AQ
Sbjct: 1247 SALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQ 1306
Query: 1299 KGLFYRL 1305
KG +Y+L
Sbjct: 1307 KGAYYKL 1313
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 164 bits (414), Expect = 7e-40
Identities = 137/485 (28%), Positives = 242/485 (49%), Gaps = 25/485 (5%)
Query: 837 VVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMY---AFGLLEVSLVVAVAT 893
V+R FF++ G++++R +++T T+ + + L L Y LL + L +V+
Sbjct: 328 VLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSL 387
Query: 894 PLATVAILPL-FLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQ 952
+ T+ LPL FLL Y + Q+R ES + SS + E VR+F +
Sbjct: 388 TMVTLITLPLLFLLPKKVGKWYQLLEVQVR--ESLAKSSQVA--IEALSAMPTVRSFANE 443
Query: 953 APFVAQNNARVDESQRISFPRLVA---DRWLAA-NVELLGNGLVFAAATCAVLSKAHLSA 1008
+ ++ E + ++ VA + W + + LL G+++ V S A S
Sbjct: 444 EGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQL-VTSGAVSSG 502
Query: 1009 GLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPW 1068
LV F V +Q TQ ++ ++ + ++ ++ S E++ +Y + R P P
Sbjct: 503 NLVTF-VLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYL----DRTPRCPPSGLLTPL 557
Query: 1069 PQGGQIEFQDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQE 1126
G ++FQD Y RP++ L +QG++F + GE +VG G+GKS++A+ L L +
Sbjct: 558 HLEGLVQFQDVSFAYPNRPDV-LVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQ 616
Query: 1127 AAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL--DLLQEHSDEAIWAAL 1184
G + +DG P+ L +++ + Q+P +F SL+ N+ L Q+ + E I AA
Sbjct: 617 PTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAA 676
Query: 1185 ETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPG 1244
+ ++ LP + + G LS GQ+Q + LARAL+RK +LILD+AT+A+D
Sbjct: 677 VKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDAN 736
Query: 1245 TELQMQAML--GSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLF 1302
++LQ++ +L +VLLI L V +L ++ G + E G+ QL+ +KG +
Sbjct: 737 SQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCY 796
Query: 1303 YRLAQ 1307
+ + Q
Sbjct: 797 WAMVQ 801
Score = 119 bits (299), Expect = 1e-26
Identities = 137/540 (25%), Positives = 250/540 (46%), Gaps = 49/540 (9%)
Query: 160 LLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVV 219
L+++L SA L+ F +Y + + S + G V+ VL + + + G+++
Sbjct: 290 LMSILTIASAVLE--FVGDGIYNNTM--GHVHSHLQGEVFGAVLRQETEFFQQNQTGNIM 345
Query: 220 NLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFIS 279
+ V+ D L++S+ L+L W +V + L ++ +++ V L LPL F +
Sbjct: 346 SRVTEDTSTLSDSLSENLSLFL---WYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLP 402
Query: 280 KKRNH-HQEEQMRQKDSRARLTS---SILRNSKTIK-FHGWEGA---FLDRVLGIRGQEL 331
KK +Q +++ ++S A+ + L T++ F EG F +++ QE+
Sbjct: 403 KKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKL-----QEI 457
Query: 332 GAL-RTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQ 390
L + + ++V+ + +S L+ + + + + + + VT + +
Sbjct: 458 KTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQA 517
Query: 391 AFLPFSIHSLVQARV-SFDRLVTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAW-S 448
+ SI+ VQ V S +++ +L + P S + + Q +FA+ +
Sbjct: 518 VEVLLSIYPRVQKAVGSSEKIFEYL---DRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPN 574
Query: 449 QESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------- 501
+ L + T+ G + A+VGP G+GKS++ + L G + ++G
Sbjct: 575 RPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEH 634
Query: 502 ------VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSF----PEGI 551
VA V QE V S+ EN+ +G P E + A A++ SF P+G
Sbjct: 635 RYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEE--ITAAAVKSGAHSFISGLPQGY 692
Query: 552 HTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLL 611
T + E G LSGGQ+Q ++LARA+ RK V +LDD +ALDA+ Q Q++
Sbjct: 693 DTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDAN-SQLQVEQLLYESPER 751
Query: 612 QGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGE 671
+ +L+T L ++ QAD I+ L GAI E G++Q+L+++KG C + P D E
Sbjct: 752 YSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKG---CYWAMVQAPADAPE 808
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 163 bits (413), Expect = 9e-40
Identities = 141/500 (28%), Positives = 242/500 (48%), Gaps = 29/500 (5%)
Query: 822 GARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD----TVDVDIPDKLRSLLM 877
G R L L ++R ++FF++T G L+NR S +T +V ++ D LR+
Sbjct: 240 GQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQ 299
Query: 878 YAFGLLEVSLVVAVATPLAT--VAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVC-- 933
+ G +S++ V+ LAT ++++P + A Y LR+L + S+
Sbjct: 300 ASVG---ISMMFFVSPNLATFVLSVVPPVSIIAVIYGRY------LRKLTKVTQDSLAQA 350
Query: 934 SHMAETFQGST-VVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLV 992
+ +AE G+ VRAF + + + ++VD +++ A L GN +V
Sbjct: 351 TQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIV 410
Query: 993 FAAATCA--VLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAW 1050
+ ++ AH++ G + + A V ++ + +++L + + R+ +
Sbjct: 411 LSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLE 470
Query: 1051 TPKEAPWRLPTCAAQPPWPQGGQIEFQDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVG 1108
+ P+ + + G +EF++ Y RPE+P+ Q S I +G +VG
Sbjct: 471 REPKLPFNEGVILNEKSFQ--GALEFKNVHFAYPARPEVPI-FQDFSLSIPSGSVTALVG 527
Query: 1109 RTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMN 1168
+G+GKS++ S LLRL + A G I +DG I + LRS+I + Q+PILF S+ N
Sbjct: 528 PSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAEN 587
Query: 1169 L----DLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARA 1224
+ D + E I E A + + P ++G LS GQKQ + +ARA
Sbjct: 588 IAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARA 647
Query: 1225 LLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKG 1284
LL+ +IL+LDEAT+A+D E +Q L TVL+IAHRL ++ + V V+D+G
Sbjct: 648 LLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQG 707
Query: 1285 QVAESGSPAQLLAQKGLFYR 1304
++ E G +LL++ YR
Sbjct: 708 KITEYGKHEELLSKPNGIYR 727
Score = 120 bits (300), Expect = 1e-26
Identities = 71/222 (31%), Positives = 122/222 (54%), Gaps = 22/222 (9%)
Query: 453 PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEG------------ 500
P +L++P G + A+VGP G+GKS++LS LL G +S++G
Sbjct: 508 PIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLR 567
Query: 501 -AVAYVPQEAWVQNTSVVENVCFGQELDPPW-----LERVLEACALQPDVDSFPEGIHTS 554
+ V QE + + S+ EN+ +G + DP ++RV E + +FP+G +T
Sbjct: 568 SKIGTVSQEPILFSCSIAENIAYGAD-DPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTV 626
Query: 555 IGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGT 614
+GE+G+ LSGGQKQR+++ARA+ + + LLD+ +ALDA +++ + + L+ G
Sbjct: 627 VGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEAL--DRLMDGR 683
Query: 615 TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGAL 656
T +++ H L + A+ + VL G I E G ++ELL + +
Sbjct: 684 TVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGI 725
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B isoform
1 [Homo sapiens]
Length = 703
Score = 154 bits (389), Expect = 5e-37
Identities = 141/540 (26%), Positives = 262/540 (48%), Gaps = 37/540 (6%)
Query: 786 VGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGG------ARASRLLFQRLLWDVVR 839
+GG A IF + CL + G +S++A GG +R + + ++L ++R
Sbjct: 180 LGGDFDPHAFASAIFFM--CLFSFG--SSLSAGCRGGCFTYTMSRINLRIREQLFSSLLR 235
Query: 840 SPISFFERTPIGHLLNRFSKETDTVDVDIP---DKLRSLLMYAFGLLEVSLVVAVATPLA 896
+ FF+ T G L +R S +T + +P + L L+ GL L ++ L
Sbjct: 236 QDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLL 295
Query: 897 TVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFV 956
++ +P + + +Y ++ R + + + E G VR+F + V
Sbjct: 296 SLLHMPFTI---AAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEV 352
Query: 957 AQNNARVDESQRISFPRLV--ADRWLAANVELLGNGLVFAAATCAVLSKAHLSAG-LVGF 1013
+ +++ +++ + R + A L V LG ++ + + L+ G L+ F
Sbjct: 353 CRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSF 412
Query: 1014 SVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQ 1073
+ V +Q +V + D+ +++ + E++ Y + LP+ P G
Sbjct: 413 MIYQE-SVGSYVQTLVYIYGDMLSNVGAAEKVFSYM----DRQPNLPSPGTLAPTTLQGV 467
Query: 1074 IEFQDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGG 1131
++FQD Y RP+ P+ ++G++F + GE +VG G+GKS++A+ L L + G
Sbjct: 468 VKFQDVSFAYPNRPDRPV-LKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ 526
Query: 1132 IWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLK 1190
+ +D PI+ L S++ + Q+P+LF GS+R N+ LQ D+ + AA +
Sbjct: 527 VLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHAD 586
Query: 1191 ALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQ 1250
+ + + ++G L+ GQKQ L +ARAL+R ++LILDEAT+A+D +Q +
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALD----VQCE 642
Query: 1251 AMLGSWFAQ--CTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1308
L W ++ TVL+IAHRL++V ++LV+ +G++ + AQL + L+ RL Q+
Sbjct: 643 QALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKL---AQLQEGQDLYSRLVQQ 699
Score = 84.3 bits (207), Expect = 7e-16
Identities = 62/226 (27%), Positives = 105/226 (46%), Gaps = 20/226 (8%)
Query: 438 ITIQSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV 496
+ Q +FA+ ++ P L + T+ G + A+VGP G+GKS++ + L G V
Sbjct: 468 VKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV 527
Query: 497 SIE-------------GAVAYVPQEAWVQNTSVVENVCFG-QELDPPWLERVLEACALQP 542
++ V V QE + + SV N+ +G Q + + +A
Sbjct: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587
Query: 543 DVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFN 602
+ GI+T +GE+G L+ GQKQRL++ARA+ R V +LD+ +ALD
Sbjct: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQC-----E 642
Query: 603 QVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQE 648
Q + T +++ H L + +A I+VL G + ++ QE
Sbjct: 643 QALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQE 688
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 144 bits (362), Expect = 7e-34
Identities = 141/533 (26%), Positives = 241/533 (45%), Gaps = 48/533 (9%)
Query: 805 CLQAIGLFASMAAVLLGG------ARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFS 858
CL AIG +S AA + GG AR + L L +V SFF+ G L++R +
Sbjct: 233 CLLAIG--SSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLT 290
Query: 859 KETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 918
+T V + + L ++V+ VV L+ L F+ GF + +VS+
Sbjct: 291 SDTTMVSDLVSQNINVFLR---NTVKVTGVVVFMFSLSWQLSLVTFM---GFPIIMMVSN 344
Query: 919 C------QLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFP 972
+L + + + + ET VR+F + ++ + +++
Sbjct: 345 IYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRK 404
Query: 973 RLVADRWLAANVELLGNGLVFAAATCAVL--------SKAHLSAGLVGFSVSAALQVTQT 1024
A + + G+GL ++L S S L+ F + + +
Sbjct: 405 EAAAYMYY-----VWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFV-LGDC 458
Query: 1025 LQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCA---AQPPWPQGGQIEFQD--F 1079
++ V ++ L + + E++ ++ R PT + P G+++F++ F
Sbjct: 459 MESVGSVYSGLMQGVGAAEKVFEFID-------RQPTMVHDGSLAPDHLEGRVDFENVTF 511
Query: 1080 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1139
R RP + +Q VSF + G+ +VG +G+GKSS + L G + +DG PI
Sbjct: 512 TYRTRPHTQV-LQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
Query: 1140 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLKALVASLPG 1198
+ L IS++ Q+P+LF S+ N+ L E + A + + L
Sbjct: 571 SAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQD 630
Query: 1199 QLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFA 1258
+ ++G LS GQKQ + +ARAL+R +LILDEAT+A+D +E +Q +
Sbjct: 631 GYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQ 690
Query: 1259 QCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGL 1311
+ TVL+IAHRL +V ++V+DKG+V + G+ QLLAQ GL+ +L Q L
Sbjct: 691 KHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQML 743
Score = 102 bits (255), Expect = 2e-21
Identities = 116/517 (22%), Positives = 225/517 (43%), Gaps = 43/517 (8%)
Query: 189 RLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESV-----LYLNGLWLPL 243
RL + ++R +++ + + GD+++ ++ D +++ V ++L
Sbjct: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
Query: 244 VWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFF--ISKKRNHHQEEQMRQKDSRARLTS 301
+V F WQL S +T + + ++ N + K+ + + + + + A T
Sbjct: 316 GVVVFMFSLSWQL---SLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETI 372
Query: 302 SILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFA 361
S ++ ++ E R L + +L + ++ V + V+++ +
Sbjct: 373 SAMKTVRSFANEEEEAEVYLRKLQ-QVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYG 431
Query: 362 VHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDP 421
H LV M + + +L + L+Q + +++ F+ + P
Sbjct: 432 GH-LVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFI---DRQP 487
Query: 422 GAVDSSSSGSAAGKDCITIQSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSS 480
V S + + ++ TF + ++ L ++ ++ G + A+VGP G+GKSS
Sbjct: 488 TMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSS 547
Query: 481 LLSALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFGQELD 527
++ L G V ++G ++ V QE + S+ +N+ +G
Sbjct: 548 CVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTV 607
Query: 528 PPWLERVLEACALQPDVDSF----PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVY 583
P E V+EA A + + F +G T GE+G LSGGQKQR+++ARA+ R V
Sbjct: 608 P--FEMVVEA-AQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVL 664
Query: 584 LLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEM 643
+LD+ +ALDA +++ Q I G LQ T +++ H L + A I+VL G + +
Sbjct: 665 ILDEATSALDAE-SEYLIQQAI--HGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQ 721
Query: 644 GSYQELLQRKGALVCLLDQ---ARQP-GDRGEGETEP 676
G++Q+LL + G L+ + QP D G EP
Sbjct: 722 GTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEP 758
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 144 bits (362), Expect = 7e-34
Identities = 141/533 (26%), Positives = 241/533 (45%), Gaps = 48/533 (9%)
Query: 805 CLQAIGLFASMAAVLLGG------ARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFS 858
CL AIG +S AA + GG AR + L L +V SFF+ G L++R +
Sbjct: 233 CLLAIG--SSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLT 290
Query: 859 KETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 918
+T V + + L ++V+ VV L+ L F+ GF + +VS+
Sbjct: 291 SDTTMVSDLVSQNINVFLR---NTVKVTGVVVFMFSLSWQLSLVTFM---GFPIIMMVSN 344
Query: 919 C------QLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFP 972
+L + + + + ET VR+F + ++ + +++
Sbjct: 345 IYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRK 404
Query: 973 RLVADRWLAANVELLGNGLVFAAATCAVL--------SKAHLSAGLVGFSVSAALQVTQT 1024
A + + G+GL ++L S S L+ F + + +
Sbjct: 405 EAAAYMYY-----VWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFV-LGDC 458
Query: 1025 LQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCA---AQPPWPQGGQIEFQD--F 1079
++ V ++ L + + E++ ++ R PT + P G+++F++ F
Sbjct: 459 MESVGSVYSGLMQGVGAAEKVFEFID-------RQPTMVHDGSLAPDHLEGRVDFENVTF 511
Query: 1080 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1139
R RP + +Q VSF + G+ +VG +G+GKSS + L G + +DG PI
Sbjct: 512 TYRTRPHTQV-LQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
Query: 1140 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLKALVASLPG 1198
+ L IS++ Q+P+LF S+ N+ L E + A + + L
Sbjct: 571 SAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQD 630
Query: 1199 QLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFA 1258
+ ++G LS GQKQ + +ARAL+R +LILDEAT+A+D +E +Q +
Sbjct: 631 GYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQ 690
Query: 1259 QCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGL 1311
+ TVL+IAHRL +V ++V+DKG+V + G+ QLLAQ GL+ +L Q L
Sbjct: 691 KHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQML 743
Score = 102 bits (255), Expect = 2e-21
Identities = 116/517 (22%), Positives = 225/517 (43%), Gaps = 43/517 (8%)
Query: 189 RLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESV-----LYLNGLWLPL 243
RL + ++R +++ + + GD+++ ++ D +++ V ++L
Sbjct: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
Query: 244 VWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFF--ISKKRNHHQEEQMRQKDSRARLTS 301
+V F WQL S +T + + ++ N + K+ + + + + + A T
Sbjct: 316 GVVVFMFSLSWQL---SLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETI 372
Query: 302 SILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFA 361
S ++ ++ E R L + +L + ++ V + V+++ +
Sbjct: 373 SAMKTVRSFANEEEEAEVYLRKLQ-QVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYG 431
Query: 362 VHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDP 421
H LV M + + +L + L+Q + +++ F+ + P
Sbjct: 432 GH-LVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFI---DRQP 487
Query: 422 GAVDSSSSGSAAGKDCITIQSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSS 480
V S + + ++ TF + ++ L ++ ++ G + A+VGP G+GKSS
Sbjct: 488 TMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSS 547
Query: 481 LLSALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFGQELD 527
++ L G V ++G ++ V QE + S+ +N+ +G
Sbjct: 548 CVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTV 607
Query: 528 PPWLERVLEACALQPDVDSF----PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVY 583
P E V+EA A + + F +G T GE+G LSGGQKQR+++ARA+ R V
Sbjct: 608 P--FEMVVEA-AQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVL 664
Query: 584 LLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEM 643
+LD+ +ALDA +++ Q I G LQ T +++ H L + A I+VL G + +
Sbjct: 665 ILDEATSALDAE-SEYLIQQAI--HGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQ 721
Query: 644 GSYQELLQRKGALVCLLDQ---ARQP-GDRGEGETEP 676
G++Q+LL + G L+ + QP D G EP
Sbjct: 722 GTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEP 758
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,024,022
Number of Sequences: 37866
Number of extensions: 2107081
Number of successful extensions: 6602
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 74
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 5958
Number of HSP's gapped (non-prelim): 326
length of query: 1312
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1198
effective length of database: 13,930,794
effective search space: 16689091212
effective search space used: 16689091212
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.