Search of human proteins with 239751156

Search of human proteins with 239751156

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform
6 [Homo sapiens]
         (560 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6...  1110   0.0  
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...  1090   0.0  
gi|239756672 PREDICTED: hypothetical protein LOC146429 [Homo sap...   868   0.0  
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   280   3e-75
gi|21361834 solute carrier family 22, member 17 isoform a [Homo ...   266   3e-71
gi|170650643 solute carrier family 22, member 23 isoform a [Homo...   248   8e-66
gi|48526516 solute carrier family 22, member 23 isoform b [Homo ...   204   2e-52
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           144   2e-34
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           144   2e-34
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          144   3e-34
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   133   4e-31
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   133   4e-31
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          132   8e-31
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          131   2e-30
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   129   7e-30
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          124   3e-28
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   120   3e-27
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   119   1e-26
gi|166064021 solute carrier family 22 (organic anion transporter...   118   2e-26
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       109   8e-24
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   108   1e-23
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        104   2e-22
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   100   5e-21
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   100   5e-21
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]           99   1e-20
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]        89   1e-17
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]        89   1e-17
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]        87   3e-17
gi|157426885 organic cation transporter like 4 [Homo sapiens]          87   4e-17
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]           86   9e-17

>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
           [Homo sapiens]
          Length = 560

 Score = 1110 bits (2870), Expect = 0.0
 Identities = 560/560 (100%), Positives = 560/560 (100%)

Query: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60
           MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA
Sbjct: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60

Query: 61  LRALRGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT 120
           LRALRGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT
Sbjct: 61  LRALRGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT 120

Query: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180
           WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA
Sbjct: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180

Query: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 240
           SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL
Sbjct: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 240

Query: 241 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 300
           VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG
Sbjct: 241 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 300

Query: 301 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF 360
           DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF
Sbjct: 301 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF 360

Query: 361 RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA 420
           RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA
Sbjct: 361 RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA 420

Query: 421 QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLD 480
           QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLD
Sbjct: 421 QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLD 480

Query: 481 TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD 540
           TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD
Sbjct: 481 TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD 540

Query: 541 HLPLLPPSNSYWAGHTPEQH 560
           HLPLLPPSNSYWAGHTPEQH
Sbjct: 541 HLPLLPPSNSYWAGHTPEQH 560


>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score = 1090 bits (2818), Expect = 0.0
 Identities = 554/560 (98%), Positives = 554/560 (98%), Gaps = 2/560 (0%)

Query: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60
           MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA
Sbjct: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60

Query: 61  LRALRGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT 120
           LRALRGPALLDAAIPRLGPTRA  P   LGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT
Sbjct: 61  LRALRGPALLDAAIPRLGPTRA--PAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT 118

Query: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180
           WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA
Sbjct: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178

Query: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 240
           SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL
Sbjct: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238

Query: 241 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 300
           VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG
Sbjct: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 298

Query: 301 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF 360
           DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF
Sbjct: 299 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF 358

Query: 361 RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA 420
           RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA
Sbjct: 359 RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA 418

Query: 421 QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLD 480
           QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAG LD
Sbjct: 419 QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLD 478

Query: 481 TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD 540
           TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD
Sbjct: 479 TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD 538

Query: 541 HLPLLPPSNSYWAGHTPEQH 560
           HLPLLPPSNSYWAGHTPEQH
Sbjct: 539 HLPLLPPSNSYWAGHTPEQH 558


>gi|239756672 PREDICTED: hypothetical protein LOC146429 [Homo
           sapiens]
          Length = 495

 Score =  868 bits (2243), Expect = 0.0
 Identities = 464/560 (82%), Positives = 473/560 (84%), Gaps = 65/560 (11%)

Query: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60
           MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA
Sbjct: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60

Query: 61  LRALRGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT 120
           LRALRGPALLDAAIPRLGPTRA  P   LGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT
Sbjct: 61  LRALRGPALLDAAIPRLGPTRA--PAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT 118

Query: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180
           WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA
Sbjct: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178

Query: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 240
           SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL
Sbjct: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238

Query: 241 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 300
           VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG
Sbjct: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 298

Query: 301 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF 360
           DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRA+ 
Sbjct: 299 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRAN- 357

Query: 361 RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA 420
                               L    ++FL +          LL    V+ L+SL     A
Sbjct: 358 --------------------LPGWTVLFLSVLG--------LLASRAVSALSSLF---AA 386

Query: 421 QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLD 480
           +  P  TV+  + LGL                             VLGAGFLGQAAGLLD
Sbjct: 387 EVFP--TVIRGAGLGL-----------------------------VLGAGFLGQAAGLLD 415

Query: 481 TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD 540
           TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD
Sbjct: 416 TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD 475

Query: 541 HLPLLPPSNSYWAGHTPEQH 560
           HLPLLPPSNSYWAGHTPEQH
Sbjct: 476 HLPLLPPSNSYWAGHTPEQH 495


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  280 bits (715), Expect = 3e-75
 Identities = 179/432 (41%), Positives = 241/432 (55%), Gaps = 7/432 (1%)

Query: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180
           W+LVC  GW+V LEQ+  +LG+  G + LG   DRFGRR + + +L L    G   A A 
Sbjct: 90  WDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAG 149

Query: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 240
           S   ++ LR L G  LAG  L +YL RLELCDP  RL  ++   L  V G  L  GLA +
Sbjct: 150 SSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALV 209

Query: 241 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 300
            +DWR LQ +      +L LF+G+P LF ES  WL+   Q+  A+ +L   AE +   P 
Sbjct: 210 SKDWRFLQRM-ITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNR--PH 266

Query: 301 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF 360
              L E +     +L   +   P     S   LL  R  W+N LILGF++ +   IR  +
Sbjct: 267 GQMLGEEAQEALQDLEN-TCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCY 325

Query: 361 RRSLAPQVPT-FYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAG 419
           +       P+ FYL   L +G  A A VFL +T D  GRR +LLL   +TG+ASL+LL  
Sbjct: 326 QPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGL 385

Query: 420 AQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLL 479
             YL    +   SVLGL +S+A + LS+L AAEV PT +RG GLGL++  G LG  +G  
Sbjct: 386 WDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPA 445

Query: 480 DTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRP-- 537
             LH   G FLQ VV A+ A+L +L ++LLPE++ + LP+ L+D +  RR  LLR  P  
Sbjct: 446 QRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPT 505

Query: 538 RQDHLPLLPPSN 549
           R DH+PLL   N
Sbjct: 506 RCDHVPLLATPN 517


>gi|21361834 solute carrier family 22, member 17 isoform a [Homo
           sapiens]
          Length = 538

 Score =  266 bits (681), Expect = 3e-71
 Identities = 180/450 (40%), Positives = 242/450 (53%), Gaps = 25/450 (5%)

Query: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180
           W+LVC  GW+V LEQ+  +LG+  G + LG   DRFGRR + + +L L    G   A A 
Sbjct: 90  WDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAG 149

Query: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 240
           S   ++ LR L G  LAG  L +YL RLELCDP  RL  ++   L  V G  L  GLA +
Sbjct: 150 SSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALV 209

Query: 241 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 300
            +DWR LQ +      +L LF+G+P LF ES  WL+   Q+  A+ +L   AE +   P 
Sbjct: 210 SKDWRFLQRM-ITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERN--RPH 266

Query: 301 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF 360
              L E +     +L   +   P     S   LL  R  W+N LILGF++ +   IR  +
Sbjct: 267 GQMLGEEAQEALQDLEN-TCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCY 325

Query: 361 RRSLAPQVPT-FYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLL-- 417
           +       P+ FYL   L +G  A A VFL +T D  GRR +LLL   +TG+ASL+LL  
Sbjct: 326 QPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGL 385

Query: 418 ----------AGAQY------LPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGA 461
                       AQ       L    +   SVLGL +S+A + LS+L AAEV PT +RG 
Sbjct: 386 WDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGR 445

Query: 462 GLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSL 521
           GLGL++  G LG  +G    LH   G FLQ VV A+ A+L +L ++LLPE++ + LP+ L
Sbjct: 446 GLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVL 505

Query: 522 QDADRLRRSPLLRGRP--RQDHLPLLPPSN 549
           +D +  RR  LLR  P  R DH+PLL   N
Sbjct: 506 RDGELCRRPSLLRQPPPTRCDHVPLLATPN 535


>gi|170650643 solute carrier family 22, member 23 isoform a [Homo
           sapiens]
          Length = 686

 Score =  248 bits (634), Expect = 8e-66
 Identities = 183/576 (31%), Positives = 278/576 (48%), Gaps = 54/576 (9%)

Query: 1   MEQEARVLRAAGGFGRA-RRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRP--DPTLL 57
           ++ +  VL   GG G   ++ L   +W+P + +G    S+  L  QP   CR     T L
Sbjct: 78  LDYDGSVLPFLGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTEL 137

Query: 58  PPALRALRGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLA------PLTRAPRPSSWAS 111
                  RG  + +       P  A +P    G  S S  A      PL   P     AS
Sbjct: 138 AGVTTTGRGGDMGNWTSLPTTPF-ATAPWEAAGNRSNSSGADGGDTPPLPSPPDKGDNAS 196

Query: 112 -CS------GAAAG------PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGR 158
            C       G  AG        W+LVC + WKV + + S L+G + G +I G   D  GR
Sbjct: 197 NCDCRAWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGR 256

Query: 159 RAVFVASLVLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLA 218
           R V + S++     G + AL+ +      LR   G  LAG +L LY  R+ELC P  R  
Sbjct: 257 RPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFM 316

Query: 219 FSMGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLAT 278
            +M A   ++ G  L+PGLAAL +DW++LQ L      L+LL+W   ++FPES  WL+AT
Sbjct: 317 ITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYW---SIFPESLRWLMAT 373

Query: 279 GQVARARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRV 338
            Q   A++++  F + + + P     E +      EL    +R  +P+    + ++ TR 
Sbjct: 374 QQFESAKRLILHFTQKNRMNP-----EGDIKGVIPELEKELSR--RPKKVCIVKVVGTRN 426

Query: 339 TWRNGLILGFSSLVGGGIRASFRRSL------APQVPTFYLPYFLEAGLEAAALVFLLLT 392
            W+N ++L  +SL G GI   F RS+       P +  FY  Y+  A +   + + + + 
Sbjct: 427 LWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVV 486

Query: 393 ADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWT---------------VLFLSVLGLL 437
               GRR  LLL  ++T LASLL L     +  ++                +  S++G+ 
Sbjct: 487 VRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMF 546

Query: 438 ASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFAS 497
           AS AV +LS  F AE+ PTVIR  GLGLVL +   G     +  LH ++G+FL  ++FA 
Sbjct: 547 ASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFAC 606

Query: 498 LAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLL 533
             ++ ++C+LLLPESR + LP+++ + +   R PLL
Sbjct: 607 CTLICIICILLLPESRDQNLPENISNGEHYTRQPLL 642


>gi|48526516 solute carrier family 22, member 23 isoform b [Homo
           sapiens]
          Length = 405

 Score =  204 bits (519), Expect = 2e-52
 Identities = 126/367 (34%), Positives = 195/367 (53%), Gaps = 31/367 (8%)

Query: 188 LRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQDWRLL 247
           LR   G  LAG +L LY  R+ELC P  R   +M A   ++ G  L+PGLAAL +DW++L
Sbjct: 5   LRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVL 64

Query: 248 QGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDSSLEEN 307
           Q L      L+LL+W   ++FPES  WL+AT Q   A++++  F + + + P     E +
Sbjct: 65  QALIICPFLLMLLYW---SIFPESLRWLMATQQFESAKRLILHFTQKNRMNP-----EGD 116

Query: 308 SLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASFRRSL--- 364
                 EL    +R  +P+    + ++ TR  W+N ++L  +SL G GI   F RS+   
Sbjct: 117 IKGVIPELEKELSR--RPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGH 174

Query: 365 ---APQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQ 421
               P +  FY  Y+  A +   + + + +     GRR  LLL  ++T LASLL L    
Sbjct: 175 EVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLN 234

Query: 422 YLPGWTV---------------LFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLV 466
            +  ++                +  S++G+ AS AV +LS  F AE+ PTVIR  GLGLV
Sbjct: 235 LIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLV 294

Query: 467 LGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADR 526
           L +   G     +  LH ++G+FL  ++FA   ++ ++C+LLLPESR + LP+++ + + 
Sbjct: 295 LASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEH 354

Query: 527 LRRSPLL 533
             R PLL
Sbjct: 355 YTRQPLL 361


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  144 bits (363), Expect = 2e-34
 Identities = 140/535 (26%), Positives = 239/535 (44%), Gaps = 54/535 (10%)

Query: 21  LASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRGPAL-LDAAIPRLGP 79
           L SA++ P I +G+V      L   P   CR  P +   +LR    PA  L+  +P  GP
Sbjct: 28  LLSATFAP-IYVGIVF-----LGFTPDHRCR-SPGVAELSLRCGWSPAEELNYTVPGPGP 80

Query: 80  TRAASP----------------CL-PLGVLSPSYLAPLTRAPRPSSWA-SCSGAAAGPTW 121
              ASP                C+ PL  L  +  + L   P    W     G++    +
Sbjct: 81  AGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNR-SRLPLGPCRDGWVYETPGSSIVTEF 139

Query: 122 NLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAAS 181
           NLVC + W + L Q S  +G+ +G + +G   DRFGR+   + ++++    G   A++ +
Sbjct: 140 NLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPT 199

Query: 182 FPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALV 241
           +  +L+ RL+ G       L  Y+   E     +R    +   +   VG L+L G+A  +
Sbjct: 200 YTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYAL 259

Query: 242 QDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGD 301
             WR LQ   AL +   LL++      PESP WL++  + A A +I+   A+ +G     
Sbjct: 260 PHWRWLQFTVALPNFFFLLYYW---CIPESPRWLISQNKNAEAMRIIKHIAKKNG----- 311

Query: 302 SSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASFR 361
                 SL  + +   L   + +    S L L+RT    ++ +IL ++      +     
Sbjct: 312 -----KSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLI 366

Query: 362 RSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQ 421
             +       YL +F  A +E  A   ++LT D  GRR       MV G A L     + 
Sbjct: 367 MHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACL----ASV 422

Query: 422 YLPG---WTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGL 478
           ++PG   W  + +S LG +       +  L  AE++PT IR  G+ +      +G   G+
Sbjct: 423 FIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIG---GI 479

Query: 479 LD--TLHGRQGFFLQ--QVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRR 529
           +    ++     +L+   +VF  L ++A   VLLLPE++ + LP+++++A+ ++R
Sbjct: 480 ITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQR 534


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  144 bits (363), Expect = 2e-34
 Identities = 122/433 (28%), Positives = 197/433 (45%), Gaps = 30/433 (6%)

Query: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180
           WNLVC D WK PL      +G LLG  I G   DRFGR+ V   ++ + TG    +  + 
Sbjct: 132 WNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSK 191

Query: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFS-MGAGLFSVVGTLLLPGLAA 239
           +F   +VL +L G       +A ++   E+     R+ FS +G  +F   G ++LP  A 
Sbjct: 192 NFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAY 251

Query: 240 LVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGP 299
            ++DWR+L     +   L +  W F    PESP WL++ G+   A  I+ + A+A+G+  
Sbjct: 252 FIRDWRMLLVALTMPGVLCVALWWF---IPESPRWLISQGRFEEAEVIIRKAAKANGI-- 306

Query: 300 GDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRAS 359
               +  +++   +EL  LS++  Q   H+ L LLR   TW   ++   S ++   I   
Sbjct: 307 ----VVPSTIFDPSELQDLSSKKQQS--HNILDLLR---TWNIRMVTIMSIMLWMTISVG 357

Query: 360 FRRSLAPQVPT----FYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLL 415
           +   L+   P      ++  FL A +E  A V   L      RR  +     + G   L 
Sbjct: 358 Y-FGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLF 416

Query: 416 LLAGAQYLPGWTVLFLSVLGLLASRAVSALSSL---FAAEVFPTVIRGAGLGLVLGAGFL 472
           +    Q +P       +VL ++    V+A  S+   + AE++PTV+R  G+G+   A  L
Sbjct: 417 M----QLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRL 472

Query: 473 GQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPL 532
           G          G    FL  ++  SL +L  +  L LPES    LP ++   D++ R   
Sbjct: 473 GSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI---DQMLRVKG 529

Query: 533 LRGRPRQDHLPLL 545
           ++ R    H  +L
Sbjct: 530 MKHRKTPSHTRML 542


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  144 bits (362), Expect = 3e-34
 Identities = 130/475 (27%), Positives = 206/475 (43%), Gaps = 27/475 (5%)

Query: 58  PPALRALRGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSG-AA 116
           PP  R      LL+AA      T A S   PL    P+  APL   P    W      + 
Sbjct: 83  PPERRGRCQRYLLEAANDSASATSALSCADPLAAF-PNRSAPLV--PCRGGWRYAQAHST 139

Query: 117 AGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASE 176
               ++LVC + W + L Q    LG+L G   LG   DR+GR  +++ S +     G   
Sbjct: 140 IVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVV 199

Query: 177 ALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPG 236
           A A +FP  ++ R L G    G  +  Y+   E+     R    +   +F  +G ++LPG
Sbjct: 200 AFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPG 259

Query: 237 LAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASG 296
           +A  + +W+ +Q    L S L LL++    + PESP WL+   +  +A +IL R A+ +G
Sbjct: 260 IAYFIPNWQGIQLAITLPSFLFLLYYW---VVPESPRWLITRKKGDKALQILRRIAKCNG 316

Query: 297 VGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGI 356
                  L  N     +E+T+       P +   L L+RT    +  LIL F+      +
Sbjct: 317 -----KYLSSN----YSEITVTDEEVSNPSF---LDLVRTPQMRKCTLILMFAWFTSAVV 364

Query: 357 RASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLL 416
                  L       Y+ +F+   +E    + +LLT +  GRR       +V G+A L+ 
Sbjct: 365 YQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLV- 423

Query: 417 LAGAQYLP---GWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLG-AGFL 472
                +LP    W    ++ LG L       +  L  +E++PT +R  G+ L  G   F 
Sbjct: 424 ---TAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFG 480

Query: 473 GQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRL 527
           G  A  L          L  ++F  LA +    V+LLPE++   LP+++ D ++L
Sbjct: 481 GIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKL 535


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  133 bits (335), Expect = 4e-31
 Identities = 153/549 (27%), Positives = 224/549 (40%), Gaps = 54/549 (9%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA-LRALR 65
           +L   GGFG  +    +   +P ++L L       L A PA  C      LP A      
Sbjct: 6   LLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCA-----LPGAPANFSH 60

Query: 66  GPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLT----------------RAPRPSSW 109
               L+A +PR  P    S CL      P  L   T                  P    W
Sbjct: 61  QDVWLEAHLPR-EPDGTLSSCLRFAY--PQALPNTTLGEERQSRGELEDEPATVPCSQGW 117

Query: 110 AS-----CSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVA 164
                   S  A    W+LVC               G L+G V  G   DRFGRR + + 
Sbjct: 118 EYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLV 177

Query: 165 SLVLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAG 224
           + V T  LG + A + S+    + R L G  LAG  + +    LE  D  HR    + + 
Sbjct: 178 AYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSS 237

Query: 225 LFSVVGTLLLPGLAALVQDWR--LLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVA 282
            F   G +LL  +  L++DWR  LL        G+L L+W      PES  WLL  G V 
Sbjct: 238 TFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWW-----VPESARWLLTQGHVK 292

Query: 283 RARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRN 342
            A + L   A  +G    + S  + +      ++ ++A     R  S L L RT    R 
Sbjct: 293 EAHRYLLHCARLNGRPVCEDSFSQEA------VSKVAAGERVVRRPSYLDLFRTP---RL 343

Query: 343 GLILGFSSLVGGGIRASFRRSLAPQVP----TFYLPYFLEAGLEAAALVFLLLTADCCGR 398
             I     +V  G+  S+   L+  V       Y    L   +E  + + + L+    GR
Sbjct: 344 RHISLCCVVVWFGVNFSY-YGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGR 402

Query: 399 RPVLLLGTMV-TGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTV 457
           R +   GT++ T LA    L  +  +  W+ + L+V+G   S A    + LF +E++PTV
Sbjct: 403 R-LTQAGTLLGTALAFGTRLLVSSDMKSWSTV-LAVMGKAFSEAAFTTAYLFTSELYPTV 460

Query: 458 IRGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGL 517
           +R  G+GL    G LG +   L  L       L ++ +  +A+LA    LLLPE+R   L
Sbjct: 461 LRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQL 520

Query: 518 PQSLQDADR 526
           P+++QD +R
Sbjct: 521 PETIQDVER 529


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  133 bits (335), Expect = 4e-31
 Identities = 152/547 (27%), Positives = 224/547 (40%), Gaps = 52/547 (9%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA-LRALR 65
           +L   GGFG  +    +   +P ++L L       L A PA  C      LP A      
Sbjct: 6   LLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCA-----LPGAPANFSH 60

Query: 66  GPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLT----------------RAPRPSSW 109
               L+A +PR  P    S CL      P  L   T                  P    W
Sbjct: 61  QDVWLEAHLPR-EPDGTLSSCLRFAY--PQALPNTTLGEERQSRGELEDEPATVPCSQGW 117

Query: 110 A---SCSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASL 166
               S   +     W+LVC               G L+G V  G   DRFGRR + + + 
Sbjct: 118 EYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAY 177

Query: 167 VLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLF 226
           V T  LG + A + S+    + R L G  LAG  + +    LE  D  HR    + +  F
Sbjct: 178 VSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTF 237

Query: 227 SVVGTLLLPGLAALVQDWR--LLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARA 284
              G +LL  +  L++DWR  LL        G+L L+W      PES  WLL  G V  A
Sbjct: 238 WTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWW-----VPESARWLLTQGHVKEA 292

Query: 285 RKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGL 344
            + L   A  +G    + S  + +      ++ ++A     R  S L L RT    R   
Sbjct: 293 HRYLLHCARLNGRPVCEDSFSQEA------VSKVAAGERVVRRPSYLDLFRTP---RLRH 343

Query: 345 ILGFSSLVGGGIRASFRRSLAPQVP----TFYLPYFLEAGLEAAALVFLLLTADCCGRRP 400
           I     +V  G+  S+   L+  V       Y    L   +E  + + + L+    GRR 
Sbjct: 344 ISLCCVVVWFGVNFSY-YGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRR- 401

Query: 401 VLLLGTMV-TGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIR 459
           +   GT++ T LA    L  +  +  W+ + L+V+G   S A    + LF +E++PTV+R
Sbjct: 402 LTQAGTLLGTALAFGTRLLVSSDMKSWSTV-LAVMGKAFSEAAFTTAYLFTSELYPTVLR 460

Query: 460 GAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQ 519
             G+GL    G LG +   L  L       L ++ +  +A+LA    LLLPE+R   LP+
Sbjct: 461 QTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPE 520

Query: 520 SLQDADR 526
           ++QD +R
Sbjct: 521 TIQDVER 527


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  132 bits (332), Expect = 8e-31
 Identities = 145/550 (26%), Positives = 227/550 (41%), Gaps = 47/550 (8%)

Query: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRAL 64
           + +L   G  G  + L  +   +P + +      +    A P  HCRP          A 
Sbjct: 4   SEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHN-------AS 56

Query: 65  RGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAP--LTRAPRP--SSWASCSGAAAGPT 120
            GP +L      +GP      CL   V  P+   P    RA  P    W   S   +  T
Sbjct: 57  TGPWVLP-----MGPNGKPERCLRF-VHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVT 110

Query: 121 -WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALA 179
            W+LVC       + Q   + G L+G ++LG   DRFGRR +   S +L    G+  A +
Sbjct: 111 EWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFS 170

Query: 180 ASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAA 239
            +FP  +V R L G  ++G  L+  +  +E      R   S   G     G  +LPGLA 
Sbjct: 171 PTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAY 230

Query: 240 LVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGP 299
            +  WR LQ     +S    +F+      PES  WL+ +G+ ++A KIL R A  +G   
Sbjct: 231 AIPQWRWLQ---LTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKE 287

Query: 300 GDS--SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIR 357
                SLEE  L    E+++  A+      ++   L R  +  R    L  +    G   
Sbjct: 288 EGERLSLEELKLNLQKEISLAKAK------YTASDLFRIPMLRRMTFCLSLAWFATGFAY 341

Query: 358 ASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLL 417
            S    +       Y+   +  G++  A    +L+    GR          T  A+LLL 
Sbjct: 342 YSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRH--------TTQAAALLLA 393

Query: 418 AGAQYLPGWTVLFL-SVLGLLASRAVSALSS------LFAAEVFPTVIRGAGLGLVLGAG 470
            GA     +  L L +V  +LA      LSS      L+ +E++PTVIR  G+G+     
Sbjct: 394 GGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWT 453

Query: 471 FLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRS 530
            +G     L  + G    F+  +++   A+L     L LPE+ ++ LP++++D   L   
Sbjct: 454 RVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIED---LENW 510

Query: 531 PLLRGRPRQD 540
            L   +P+Q+
Sbjct: 511 SLRAKKPKQE 520


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  131 bits (329), Expect = 2e-30
 Identities = 155/551 (28%), Positives = 228/551 (41%), Gaps = 57/551 (10%)

Query: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHC----RPDPTLLPPA 60
           + +L   GG GR + L   A  V  + L      E    A P+  C      + T     
Sbjct: 4   SELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASI 63

Query: 61  LRALRGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRA---------PRPSSWA- 110
           L +L   ALL  +IP  GP +    C          L P   A         P    W  
Sbjct: 64  LGSLSPEALLAISIPP-GPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVY 122

Query: 111 --SCSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVL 168
             S   +     WNLVC      P+ Q  +L G L+G    G   DRFGRR V   S + 
Sbjct: 123 DRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQ 182

Query: 169 TTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLE--------LCDPPHRLAFS 220
              +G + A A +FP   + R L    +AG ++      +E        L    + L FS
Sbjct: 183 MAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFS 242

Query: 221 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQ 280
            G GL + V        A  V+DW LLQ + ++   L  L+  + A   ES  WLL TG+
Sbjct: 243 FGHGLTAAV--------AYGVRDWTLLQLVVSVPFFLCFLYSWWLA---ESARWLLTTGR 291

Query: 281 VARARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLL------ 334
           +    + LWR A  +G G    +L    L +A    +   + P     + LG L      
Sbjct: 292 LDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPP-----ASLGTLLRMPGL 346

Query: 335 --RTRVTWRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLT 392
             RT ++       GF+     G+    + +L   +  F L  F+   ++  A +  LL 
Sbjct: 347 RFRTCISTLCWFAFGFTFF---GLALDLQ-ALGSNI--FLLQMFIGV-VDIPAKMGALLL 399

Query: 393 ADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAE 452
               GRRP L    ++ GL  +L      +  G     L+VLGL    A     +++++E
Sbjct: 400 LSHLGRRPTLAASLLLAGLC-ILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSE 458

Query: 453 VFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPES 512
           +FPTV+R   +GL   A   G   G L  L G  G +L  +V+ ++ VL+ L  LLLPE+
Sbjct: 459 LFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPET 518

Query: 513 RSRGLPQSLQD 523
           +S  LP ++QD
Sbjct: 519 QSLPLPDTIQD 529


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  129 bits (324), Expect = 7e-30
 Identities = 140/546 (25%), Positives = 234/546 (42%), Gaps = 50/546 (9%)

Query: 21  LASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRGPAL-LDAAIPRLGP 79
           L SA++ P I +G+V      L   P  HC+  P +   + R    PA  L+  +P LGP
Sbjct: 27  LLSAAFAP-ICVGIVF-----LGFTPDHHCQ-SPGVAELSQRCGWSPAEELNYTVPGLGP 79

Query: 80  T----------------RAASPCL-PLGVLSPSYLAPLTRAPRPSSWA-SCSGAAAGPTW 121
                            ++A  C+ PL  L+ +  + L   P    W     G++    +
Sbjct: 80  AGEAFLGQCRRYEVDWNQSALSCVDPLASLATNR-SHLPLGPCQDGWVYDTPGSSIVTEF 138

Query: 122 NLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAAS 181
           NLVC D WK+ L Q     G+L G + +G   DRFGR+   + ++++    G   A + +
Sbjct: 139 NLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPN 198

Query: 182 FPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALV 241
           + ++L+ RLL G    G  +A Y    E      R   ++   +   VG + L GLA  +
Sbjct: 199 YMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYAL 258

Query: 242 QDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGD 301
             WR LQ   +L + L LL++      PESP WLL+  +   A KI+   A+ +G  P  
Sbjct: 259 PHWRWLQLAVSLPTFLFLLYYW---CVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLP-- 313

Query: 302 SSLEENSLATATELTMLSARSPQPRYHSP--LGLLRTRVTWRNGLILGFSSLVGGGIRAS 359
                       +L MLS         SP    L RT    +   IL +       +   
Sbjct: 314 ----------PADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQG 363

Query: 360 FRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAG 419
               +       YL +   A +E       L+T D  GR   + +  ++ G A L+++  
Sbjct: 364 LILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFI 423

Query: 420 AQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLL 479
           +  L  W  + +  +G +       +  L  AE++PT +R  G+ +      +G      
Sbjct: 424 SPDL-HWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPF 482

Query: 480 DTLHGRQGF-FLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPR 538
                R+ +  L  ++FA L +LA    LLLPE++   LP++++DA+ L R    + +P+
Sbjct: 483 IVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGR----KAKPK 538

Query: 539 QDHLPL 544
           ++ + L
Sbjct: 539 ENTIYL 544


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  124 bits (310), Expect = 3e-28
 Identities = 112/414 (27%), Positives = 182/414 (43%), Gaps = 25/414 (6%)

Query: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180
           WNLVC D WKVPL      +G LLG  + G   DRFGR+ V  A++ + TG    +  + 
Sbjct: 132 WNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSI 191

Query: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFS-MGAGLFSVVGTLLLPGLAA 239
           S+    VL ++ G       +  ++   E+     R+ FS +G   F  VG +LLP  A 
Sbjct: 192 SWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAY 251

Query: 240 LVQDWRLLQGLGALMSGLLLL-FWGFPALFPESPCWLLATGQVARARKILWRFAEASGVG 298
            ++DWR+L  L   + G+L +  W F    PESP WL++  +   A  I+ + A+ + + 
Sbjct: 252 FIRDWRMLL-LALTVPGVLCVPLWWF---IPESPRWLISQRRFREAEDIIQKAAKMNNI- 306

Query: 299 PGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRA 358
               ++      +  EL  L  +         L L RT    RN  I+   SL+   + +
Sbjct: 307 ----AVPAVIFDSVEELNPLKQQKA-----FILDLFRT----RNIAIMTIMSLLLWMLTS 353

Query: 359 SFRRSLAPQVPTF----YLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASL 414
               +L+   P      YL  FL A +E  A +   L      RR  ++   +  G   L
Sbjct: 354 VGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRR-YIIAAVLFWGGGVL 412

Query: 415 LLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQ 474
           L +        +  + L +LG     +  ++  +F AE++PT++R   +G+   A  +G 
Sbjct: 413 LFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGS 472

Query: 475 AAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLR 528
                    G     L  +V  SL VL  +  L  PES    LP++L+   +++
Sbjct: 473 IIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVK 526


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  120 bits (302), Expect = 3e-27
 Identities = 134/559 (23%), Positives = 221/559 (39%), Gaps = 43/559 (7%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L+  GG GR +++  +   +P +++    + +    A P  HCRP      PA   L  
Sbjct: 6   LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRP------PADANLSK 59

Query: 67  PALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSGAAAG-------- 118
              L+  +PR    R   P   L   SP +  P       +   +      G        
Sbjct: 60  NGGLEVWLPR---DRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTF 116

Query: 119 -----PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLG 173
                  W+LVC       L Q  +++G LLG ++ G   DR GRR V + + + T   G
Sbjct: 117 PSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSG 176

Query: 174 ASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLL 233
              A A +FP     RLL G  LAG  L      +E      R       G    +G  L
Sbjct: 177 TCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFL 236

Query: 234 LPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAE 293
           L G+A  V  WR LQ    L+S     F+ +   F ES  W  ++G++    + L R A 
Sbjct: 237 LAGVAYAVPHWRHLQ---LLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVAR 293

Query: 294 ASGVGPGDSSLEENSLATAT--ELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSL 351
            +G     + L    L  +   ELTM   ++      S + LLR        L L     
Sbjct: 294 INGKREEGAKLSMEVLRASLQKELTMGKGQA------SAMELLRCPTLRHLFLCLSMLWF 347

Query: 352 VGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGL 411
                       L     + YL   +   ++  A +   L  +  GRRP  +   ++ G+
Sbjct: 348 ATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGI 407

Query: 412 ASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSS---LFAAEVFPTVIRGAGLGLVLG 468
              +LL G   +P    +  + L +L    ++A  +   L+  E++PT+IR  G+G+   
Sbjct: 408 C--ILLNGV--IPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGST 463

Query: 469 AGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLR 528
              +G     L ++       +   ++ ++ V A    +LLPE+  + LP ++QD +  +
Sbjct: 464 MARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRK 523

Query: 529 RSPLLRGRPRQDHLPLLPP 547
                + R +Q+H   + P
Sbjct: 524 GK---QTRQQQEHQKYMVP 539


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  119 bits (297), Expect = 1e-26
 Identities = 130/537 (24%), Positives = 212/537 (39%), Gaps = 40/537 (7%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L+  GG GR +++  +   +P +++    + +    A P  HCRP      PA   L  
Sbjct: 6   LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRP------PADANLSK 59

Query: 67  PALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSGAAAG-------- 118
              L+  +PR    R   P   L   SP +  P       +   +      G        
Sbjct: 60  NGGLEVWLPR---DRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTF 116

Query: 119 -----PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLG 173
                  W+LVC       L Q  +++G LLG ++ G   DR GRR V + + + T   G
Sbjct: 117 PSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSG 176

Query: 174 ASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLL 233
              A A +FP     RLL G  LAG  L      +E      R       G    +G  L
Sbjct: 177 TCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFL 236

Query: 234 LPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAE 293
           L G+A  V  WR LQ    L+S     F+ +   F ES  W  ++G++    + L R A 
Sbjct: 237 LAGVAYAVPHWRHLQ---LLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVAR 293

Query: 294 ASGVGPGDSSLEENSLATA--TELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSL 351
            +G     + L    L  +   ELTM   ++      S + LLR        L L     
Sbjct: 294 INGKREEGAKLSMEVLRASLQKELTMGKGQA------SAMELLRCPTLRHLFLCLSMLWF 347

Query: 352 VGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGL 411
                       L     + YL   +   ++  A +   L  +  GRRP  +   ++ G+
Sbjct: 348 ATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGI 407

Query: 412 ASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSS---LFAAEVFPTVIRGAGLGLVLG 468
              +LL G   +P    +  + L +L    ++A  +   L+  E++PT+IR  G+G+   
Sbjct: 408 C--ILLNGV--IPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGST 463

Query: 469 AGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDAD 525
              +G     L ++       +   ++ ++ V A    +LLPE+  + LP ++QD +
Sbjct: 464 MARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLE 520


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  118 bits (295), Expect = 2e-26
 Identities = 121/416 (29%), Positives = 190/416 (45%), Gaps = 38/416 (9%)

Query: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180
           +NLVC         Q   + G L+G ++ G  CDR GR+A  +A L+L T +G + A   
Sbjct: 127 FNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVP 186

Query: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 240
           SF   + LR      +AG   +      E   P  R    + A     +G ++L GLA  
Sbjct: 187 SFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYG 246

Query: 241 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS--GVG 298
            ++WRLLQ  G      LLLF+ F AL PES  WLL  G++  A +++ + A  +   + 
Sbjct: 247 FRNWRLLQITGTAPG--LLLFFYFWAL-PESARWLLTRGRMDEAIQLIQKAASVNRRKLS 303

Query: 299 PG--DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGI 356
           P   +  + E +  +   L +   R PQ R          +VT     +    SL   G 
Sbjct: 304 PELMNQLVPEKTGPSGNALDLF--RHPQLR----------KVTLIIFCVWFVDSLGYYG- 350

Query: 357 RASFRRSLAPQVPTF----YLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLA 412
                  L+ QV  F    YL   +   +E  A    +      GR+   L   ++ GL 
Sbjct: 351 -------LSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLM 403

Query: 413 SLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFL 472
            ++++     LP   V  L+V+G +A+ A   +S +++AE+FPT++R  G+GLV   G  
Sbjct: 404 CIIIIFIPADLP-VVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLV---GIF 459

Query: 473 GQAAGLLD---TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDAD 525
            +  G+L     L G     L  +++ SL ++A L   LLPE+  +GL  +LQD +
Sbjct: 460 SRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  109 bits (272), Expect = 8e-24
 Identities = 143/538 (26%), Positives = 219/538 (40%), Gaps = 38/538 (7%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L A G  GR +    +   +PC +L      +    A P  HCR  P     A     G
Sbjct: 6   LLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCR-GPANHTEASTNDSG 64

Query: 67  PALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT------ 120
            A L A IP L    A  PC        + L+P +  P  ++     G     +      
Sbjct: 65  -AWLRATIP-LDQLGAPEPCRRFTKPQWALLSPNSSIPGAATEGCKDGWVYNRSVFPSTI 122

Query: 121 ---WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEA 177
              W+LVC       L Q  ++ G L+G  + G+  DR G +   V S +     GA+ A
Sbjct: 123 VMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAATA 182

Query: 178 LAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGL 237
             +SF    V R L G T +G +L      +E      R    +  G    +G L+L G+
Sbjct: 183 YFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILAGV 242

Query: 238 AALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGV 297
           A L++ WR LQ     +S   L+F+ +    PES  WLL  G+   A + L + A  +G 
Sbjct: 243 AYLIRPWRCLQ---FAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGR 299

Query: 298 GPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRT----RVTWRNGLILGFSSLVG 353
                 L +  +++  +    S  +     +S L L RT    +VT    +I   +S+  
Sbjct: 300 KEEGERLTKEVMSSYIQSEFASVCTS----NSILDLFRTPAIRKVTCCLMVIWFSNSVAY 355

Query: 354 GGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRP-----VLLLGTMV 408
            G+    ++       + YL   L   +   A++    T    GRR      ++L G MV
Sbjct: 356 YGLAMDLQKFGL----SLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMV 411

Query: 409 TGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLG 468
             +A++ +  G Q L   T       G LAS  +     LF  E++PT IR  G+G    
Sbjct: 412 --IANMFVPEGTQIL--CTAQAALGKGCLASSFICVY--LFTGELYPTEIRQMGMGFASV 465

Query: 469 AGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADR 526
              LG     L T  G     L  V F + A+LA L V +L E+R+  L +++   +R
Sbjct: 466 HARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMER 523


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  108 bits (271), Expect = 1e-23
 Identities = 119/463 (25%), Positives = 192/463 (41%), Gaps = 45/463 (9%)

Query: 21  LASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRGPAL-LDAAIPRLGP 79
           L SA++ P I +G+V      L   P  HC+  P +   + R    PA  L+  +P LGP
Sbjct: 27  LLSAAFAP-ICVGIVF-----LGFTPDHHCQ-SPGVAELSQRCGWSPAEELNYTVPGLGP 79

Query: 80  T----------------RAASPCL-PLGVLSPSYLAPLTRAPRPSSWA-SCSGAAAGPTW 121
                            ++A  C+ PL  L+ +  + L   P    W     G++    +
Sbjct: 80  AGEAFLGQCRRYEVDWNQSALSCVDPLASLATNR-SHLPLGPCQDGWVYDTPGSSIVTEF 138

Query: 122 NLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAAS 181
           NLVC D WK+ L Q     G+L G + +G   DRFGR+   + ++++    G   A + +
Sbjct: 139 NLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPN 198

Query: 182 FPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALV 241
           + ++L+ RLL G    G  +A Y    E      R   ++   +   VG + L GLA  +
Sbjct: 199 YMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYAL 258

Query: 242 QDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGD 301
             WR LQ   +L + L LL++      PESP WLL+  +   A KI+   A+ +G  P  
Sbjct: 259 PHWRWLQLAVSLPTFLFLLYYW---CVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLP-- 313

Query: 302 SSLEENSLATATELTMLSARSPQPRYHSP--LGLLRTRVTWRNGLILGFSSLVGGGIRAS 359
                       +L MLS         SP    L RT    +   IL +       +   
Sbjct: 314 ----------PADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQG 363

Query: 360 FRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAG 419
               +       YL +   A +E       L+T D  GR   + +  ++ G A L+++  
Sbjct: 364 LILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFI 423

Query: 420 AQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAG 462
           +  L  W  + +  +G +       +  L  AE++PT + G G
Sbjct: 424 SPDL-HWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVG 465


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  104 bits (260), Expect = 2e-22
 Identities = 109/417 (26%), Positives = 176/417 (42%), Gaps = 28/417 (6%)

Query: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180
           WNLVC   W   L Q   + G LLG V  G   DR GRR V  A+       G + A A 
Sbjct: 144 WNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAV 203

Query: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 240
            + T +  R       +G L+  ++  +E      R   S+    F  VGTLL+     L
Sbjct: 204 DYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYL 263

Query: 241 VQDWRLLQG-LGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGP 299
           V+ W L Q  L  +    +L  W    + PE+P WLL+ G+   A+KI+   A+ +    
Sbjct: 264 VRTWWLYQMILSTVTVPFILCCW----VLPETPFWLLSEGRYEEAQKIVDIMAKWNRA-- 317

Query: 300 GDSSLEENSLATATELTMLSARSPQPRYHSPLGLL-------RTRVTWRNGLILGFSSLV 352
             SS + + L +      +S    + + H+   L        RT   W    ++ F+  +
Sbjct: 318 --SSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVW----LIWFTGSL 371

Query: 353 GGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLA 412
           G     SF  +        YL  FL   +E  A  F+ +  D  GRR VL      + LA
Sbjct: 372 GF---YSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALA 428

Query: 413 S--LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAG 470
              ++++    Y+ G   +  +++G  A  A   L  L+ AE++PT++R   +G      
Sbjct: 429 CGVVMVIPQKHYILG---VVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVC 485

Query: 471 FLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRL 527
            L                F+ Q+   ++A+L+ +  L LPE+  + L  + ++A +L
Sbjct: 486 RLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKL 542


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  100 bits (248), Expect = 5e-21
 Identities = 116/471 (24%), Positives = 182/471 (38%), Gaps = 40/471 (8%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L+  GG GR +++  +   +P +++    + +    A P  HCRP      PA   L  
Sbjct: 6   LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRP------PADANLSK 59

Query: 67  PALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSGAAAG-------- 118
              L+  +PR    R   P   L   SP +  P       +   +      G        
Sbjct: 60  NGGLEVWLPR---DRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTF 116

Query: 119 -----PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLG 173
                  W+LVC       L Q  +++G LLG ++ G   DR GRR V + + + T   G
Sbjct: 117 PSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSG 176

Query: 174 ASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLL 233
              A A +FP     RLL G  LAG  L      +E      R       G    +G  L
Sbjct: 177 TCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFL 236

Query: 234 LPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAE 293
           L G+A  V  WR LQ    L+S     F+ +   F ES  W  ++G++    + L R A 
Sbjct: 237 LAGVAYAVPHWRHLQ---LLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVAR 293

Query: 294 ASGVGPGDSSLEENSLATA--TELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSL 351
            +G     + L    L  +   ELTM   ++      S + LLR        L L     
Sbjct: 294 INGKREEGAKLSMEVLRASLQKELTMGKGQA------SAMELLRCPTLRHLFLCLSMLWF 347

Query: 352 VGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGL 411
                       L     + YL   +   ++  A +   L  +  GRRP  +   ++ G+
Sbjct: 348 ATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGI 407

Query: 412 ASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSS---LFAAEVFPTVIR 459
              +LL G   +P    +  + L +L    ++A  +   L+  E++PT+IR
Sbjct: 408 C--ILLNGV--IPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR 454


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  100 bits (248), Expect = 5e-21
 Identities = 116/471 (24%), Positives = 182/471 (38%), Gaps = 40/471 (8%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L+  GG GR +++  +   +P +++    + +    A P  HCRP      PA   L  
Sbjct: 6   LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRP------PADANLSK 59

Query: 67  PALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSGAAAG-------- 118
              L+  +PR    R   P   L   SP +  P       +   +      G        
Sbjct: 60  NGGLEVWLPR---DRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTF 116

Query: 119 -----PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLG 173
                  W+LVC       L Q  +++G LLG ++ G   DR GRR V + + + T   G
Sbjct: 117 PSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSG 176

Query: 174 ASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLL 233
              A A +FP     RLL G  LAG  L      +E      R       G    +G  L
Sbjct: 177 TCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFL 236

Query: 234 LPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAE 293
           L G+A  V  WR LQ    L+S     F+ +   F ES  W  ++G++    + L R A 
Sbjct: 237 LAGVAYAVPHWRHLQ---LLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVAR 293

Query: 294 ASGVGPGDSSLEENSLATA--TELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSL 351
            +G     + L    L  +   ELTM   ++      S + LLR        L L     
Sbjct: 294 INGKREEGAKLSMEVLRASLQKELTMGKGQA------SAMELLRCPTLRHLFLCLSMLWF 347

Query: 352 VGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGL 411
                       L     + YL   +   ++  A +   L  +  GRRP  +   ++ G+
Sbjct: 348 ATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGI 407

Query: 412 ASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSS---LFAAEVFPTVIR 459
              +LL G   +P    +  + L +L    ++A  +   L+  E++PT+IR
Sbjct: 408 C--ILLNGV--IPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR 454


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 135/539 (25%), Positives = 213/539 (39%), Gaps = 32/539 (5%)

Query: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRAL 64
           +++L  AGG G  + L      +PC+++   +  E    A P   C         A+   
Sbjct: 4   SKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTN 63

Query: 65  RGP-ALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRA---------PRPSSWA---S 111
             P ALL  +IP  GP +    C          L P   A         P    W    S
Sbjct: 64  MTPKALLTISIPP-GPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRS 122

Query: 112 CSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTG 171
              +     W+LVC      PL Q   + G L+G  I G    RFGR+ +     +    
Sbjct: 123 VFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAV 182

Query: 172 LGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGT 231
            G S   A +F     LR +    +AG  L+     +E      R       G     G 
Sbjct: 183 AGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQ 242

Query: 232 LLLPGLAALVQDWRLLQGLGAL-MSGLLLLFWGFPALFPESPCWLLATGQVARARKILWR 290
             L GLA  ++DWR LQ   ++    + L+ W      PES  WL+  G+  +A + L +
Sbjct: 243 AALGGLAFALRDWRTLQLAASVPFFAISLISW----WLPESARWLIIKGKPDQALQELRK 298

Query: 291 FAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRV-TWRN--GLILG 347
            A  +G      +L    L ++ +  + SA+ P+    S L L    V  WR+   L++ 
Sbjct: 299 VARINGHKEA-KNLTIEVLMSSVKEEVASAKEPR----SVLDLFCVPVLRWRSCAMLVVN 353

Query: 348 FSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTM 407
           FS L+         +SL   +   +L   L   ++        L     GRR +      
Sbjct: 354 FSLLISYYGLVFDLQSLGRDI---FLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQA 410

Query: 408 VTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVL 467
           + GLA L  +   Q L    V+F +VLG           +++ AE+FPT +R    G++ 
Sbjct: 411 MAGLAILANMLVPQDLQTLRVVF-AVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILH 469

Query: 468 GAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVL-LLPESRSRGLPQSLQDAD 525
             G LG   G L  +  +    L  +++  +++ + L VL  LPE++   LP ++QD +
Sbjct: 470 TVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLE 528


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 114/426 (26%), Positives = 175/426 (41%), Gaps = 34/426 (7%)

Query: 111 SCSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTT 170
           S S  +    W L+    +KV         G  +G +  G   DRFGR+ V++    L  
Sbjct: 91  SSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDI 150

Query: 171 GLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPH-RLAFSMGAGLFSVV 229
               +   + S+    V R L G    G  L  ++   E     +  LA S+G GLF  V
Sbjct: 151 LFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIG-GLFFAV 209

Query: 230 GTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILW 289
           G      L   ++ WR L  L  L   ++ L   F    PESP WL + G+++ A + L+
Sbjct: 210 GIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLF---IPESPRWLYSQGRLSEAEEALY 266

Query: 290 RFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFS 349
             A+               L     LT  + RS +    S L L R RV   + LIL F 
Sbjct: 267 LIAK-----------RNRKLKCTFSLTHPANRSCR-ETGSFLDLFRYRVLLGHTLILMFI 314

Query: 350 SLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAA--LVFLLLTADCCGRRPVLLLGTM 407
             V   +      S      + Y    L   +E  +  L   L+     GR+  L     
Sbjct: 315 WFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLC 374

Query: 408 VTGLASLLLLAGAQYLPGW--TVLF-------LSVLGLLASRAVSALSSLFAAEVFPTVI 458
           + GLA L+++    +LP    T +F       LS+LG L   A   +  ++ +E++PTVI
Sbjct: 375 LGGLACLIVM----FLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVI 430

Query: 459 RGAGLGLV-LGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGL 517
           R  GLG   + +   G  A  + +L   Q + L  +VF +  + + L  LLLPE+ +  L
Sbjct: 431 RNVGLGTCSMFSRVGGIIAPFIPSLKYVQ-WSLPFIVFGATGLTSGLLSLLLPETLNSPL 489

Query: 518 PQSLQD 523
            ++  D
Sbjct: 490 LETFSD 495


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 106/414 (25%), Positives = 176/414 (42%), Gaps = 16/414 (3%)

Query: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180
           W+LVC       + Q   L G L+G +I G   DRFGRR +    L+         A A 
Sbjct: 135 WDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCLLQLAITDTCAAFAP 194

Query: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHR-LAFSMGAGLFSVVGTLLLPGLAA 239
           +FP   VLR L G +    +    L   E   P  + L   + +G  S +G ++L GLA 
Sbjct: 195 TFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGALS-IGQIILGGLAY 253

Query: 240 LVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGP 299
           + +DW   Q L  + S    +F+       ES  WL+ T ++    K L + A  +G+  
Sbjct: 254 VFRDW---QTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRKVARTNGIKN 310

Query: 300 GDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRAS 359
            + +L    + +  +  + +A++      +   L R     +   IL F           
Sbjct: 311 AEETLNIEVVRSTMQEELDAAQTKT----TVCDLFRNPSMRKRICILVFLRFANTIPFYG 366

Query: 360 FRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAG 419
              +L       +L   L   +        LLT +  GRR   +L   + GL+ L     
Sbjct: 367 TMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILANTFV 426

Query: 420 AQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQA-AGL 478
            + +    V  L+ LG+  S A  +  ++   E+ PTV+R    G+ L A  +G A A L
Sbjct: 427 PKEMQTLRVA-LACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGAALAPL 485

Query: 479 LDTLHGRQGFF--LQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRS 530
           L TL     FF  L  +++    ++  L V LLPE+++  LP +++D +  +++
Sbjct: 486 LMTL---TVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKN 536


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 114/418 (27%), Positives = 178/418 (42%), Gaps = 24/418 (5%)

Query: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180
           W+LVC       + Q   + G LLG +I G   DR GR+ +     +         A A 
Sbjct: 135 WDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLAISNTCAAFAP 194

Query: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 240
           +F    +LR L G +    L   ++  LE   P  R    M       VG +LL GLA  
Sbjct: 195 TFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYSVGQMLLGGLAFA 254

Query: 241 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 300
           +QDW +LQ    + + +++LF     +  ES  WL+   Q+    K L R A  +G    
Sbjct: 255 IQDWHILQ--LTVSTPIIVLFLSSWKMV-ESARWLIINNQLDEGLKELRRVAHINGKKNT 311

Query: 301 DSSLEENSLATATELTMLSAR---SPQPRYHSPLGLLRTRVTW----RNGLILGFSSLVG 353
           + +L    + +  +  + + R   S    + +P   LR RV      R  + + F  L+ 
Sbjct: 312 EETLTTELVRSTMKKELDAVRIKTSIFSLFRAP--KLRMRVFGLCFVRFAITVPFYGLIL 369

Query: 354 GGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLAS 413
                   + L   V  F +   L   +   A    LLT +  GRR   +L T   GL  
Sbjct: 370 N------LQHLGSNVSLFQI---LCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420

Query: 414 LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLG 473
           L+     Q +    V+ L+ LG+ +  A S  +S+   E+ PT++R    G+   +G  G
Sbjct: 421 LVNTFLPQEMQILRVV-LATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTG 479

Query: 474 QA-AGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRS 530
            A A LL TL       L  + +    +LA+  +LLLPE+R   LP ++QD +  + S
Sbjct: 480 AALAPLLMTLMAYSP-HLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENEKDS 536


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 128/559 (22%), Positives = 216/559 (38%), Gaps = 68/559 (12%)

Query: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRAL 64
           A +L A G FG  ++ L + +++P I+    + ++  +     P+C     L        
Sbjct: 53  ANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAV------ 106

Query: 65  RGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRP-----------SSWASCS 113
            GP L  A   +L  T   +P       + S+L      P P           +   +C 
Sbjct: 107 -GPHLSKA--EQLNLTIPQAP-------NGSFLTCFMYLPVPWNLDSIIQFGLNDTDTCQ 156

Query: 114 GAAAGP---------TWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVA 164
                P          ++LVCG   K    Q+  + G  +G +I     D+ GR    + 
Sbjct: 157 DGWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILL 216

Query: 165 SLVLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAG 224
           SL+     G   A   SF   L  R     ++ G  ++      E     HR    +   
Sbjct: 217 SLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGH 276

Query: 225 LFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARA 284
            F  VG +LL G+A  +  W+LL  +G +   L++ F  +  + PESP WL+  G+V  A
Sbjct: 277 CFFAVGAVLLTGIAYSLPHWQLLFLVGGI---LVIPFISYIWILPESPRWLMMKGKVKEA 333

Query: 285 RKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGL 344
           +++L   A  +      + L+E  L    ++T  S           L   + R   +  L
Sbjct: 334 KQVLCYAASVNKKTIPSNLLDELQL-PRKKVTRASV----------LDFCKNRQLCKVTL 382

Query: 345 ILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRR---PV 401
           ++            +    +     + +  + + + +E  A +  +      GR+    V
Sbjct: 383 VMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAV 442

Query: 402 LLLGTMVTGLASLLLLAG------------AQYLPGWTVLFLSVLGLLASRAVSALSSLF 449
            LL  ++  L  L L  G            A  L   T+L L +L   +  A   +  L+
Sbjct: 443 TLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVL-MLREFSLAATVTVFFLY 501

Query: 450 AAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLL 509
            AE+ PTV+R  GLGLV  A   G    L  T+  +    L   +   LA++A     LL
Sbjct: 502 TAELLPTVLRATGLGLVSLASVAGAILSL--TIISQTPSLLPIFLCCVLAIVAFSLSSLL 559

Query: 510 PESRSRGLPQSLQDADRLR 528
           PE+R + L +SL  + ++R
Sbjct: 560 PETRDQPLSESLNHSSQIR 578


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 94/315 (29%), Positives = 144/315 (45%), Gaps = 32/315 (10%)

Query: 217 LAFSMGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLL 276
           L FS G GL + V        A  V+DW LLQ + ++   L  L+  + A   ES  WLL
Sbjct: 18  LGFSFGHGLTAAV--------AYGVRDWTLLQLVVSVPFFLCFLYSWWLA---ESARWLL 66

Query: 277 ATGQVARARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLL-- 334
            TG++    + LWR A  +G G    +L    L +A    +   + P     + LG L  
Sbjct: 67  TTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPP-----ASLGTLLR 121

Query: 335 ------RTRVTWRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVF 388
                 RT ++       GF+     G+    + +L   +  F L  F+   ++  A + 
Sbjct: 122 MPGLRFRTCISTLCWFAFGFTFF---GLALDLQ-ALGSNI--FLLQMFIGV-VDIPAKMG 174

Query: 389 LLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSL 448
            LL     GRRP L    ++ GL  +L      +  G     L+VLGL    A     ++
Sbjct: 175 ALLLLSHLGRRPTLAASLLLAGLC-ILANTLVPHEMGALRSALAVLGLGGVGAAFTCITI 233

Query: 449 FAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLL 508
           +++E+FPTV+R   +GL   A   G   G L  L G  G +L  +V+ ++ VL+ L  LL
Sbjct: 234 YSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALL 293

Query: 509 LPESRSRGLPQSLQD 523
           LPE++S  LP ++QD
Sbjct: 294 LPETQSLPLPDTIQD 308


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.140    0.440 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,470,498
Number of Sequences: 37866
Number of extensions: 1120834
Number of successful extensions: 5078
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 4854
Number of HSP's gapped (non-prelim): 228
length of query: 560
length of database: 18,247,518
effective HSP length: 107
effective length of query: 453
effective length of database: 14,195,856
effective search space: 6430722768
effective search space used: 6430722768
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.