Search of human proteins with 117938307

Search of human proteins with 117938307

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|117938307 doublecortin domain containing 2 [Homo sapiens]
         (476 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|117938307 doublecortin domain containing 2 [Homo sapiens]          941   0.0  
gi|150456471 doublecortin domain containing 2B [Homo sapiens]         196   5e-50
gi|239753110 PREDICTED: doublecortin domain-containing protein E...   186   5e-47
gi|239747673 PREDICTED: doublecortin domain-containing protein E...   182   4e-46
gi|239741542 PREDICTED: doublecortin domain-containing protein E...   182   8e-46
gi|4758128 doublecortin-like kinase 1 [Homo sapiens]                  103   4e-22
gi|30181244 doublecortin isoform c [Homo sapiens]                      96   9e-20
gi|30181240 doublecortin isoform c [Homo sapiens]                      96   9e-20
gi|30181246 doublecortin isoform a [Homo sapiens]                      96   9e-20
gi|30181242 doublecortin isoform b [Homo sapiens]                      95   2e-19
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]       92   8e-19
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]       92   1e-18
gi|5454016 retinitis pigmentosa RP1 protein [Homo sapiens]             82   1e-15
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              65   1e-10
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap...    52   1e-06
gi|157738619 smoothelin-like 1 [Homo sapiens]                          49   8e-06
gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]                48   2e-05
gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens]                 48   2e-05
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    47   3e-05
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    47   3e-05
gi|4557509 cylicin 2 [Homo sapiens]                                    47   4e-05
gi|217330641 IWS1 homolog [Homo sapiens]                               47   4e-05
gi|13540523 nucleosomal binding protein 1 [Homo sapiens]               46   6e-05
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]           46   6e-05
gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]           46   6e-05
gi|222537747 hypothetical protein LOC342979 [Homo sapiens]             45   1e-04
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    45   1e-04
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    45   1e-04
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    45   2e-04
gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homo...    44   3e-04

>gi|117938307 doublecortin domain containing 2 [Homo sapiens]
          Length = 476

 Score =  941 bits (2432), Expect = 0.0
 Identities = 476/476 (100%), Positives = 476/476 (100%)

Query: 1   MSGSSARSSHLSQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFG 60
           MSGSSARSSHLSQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFG
Sbjct: 1   MSGSSARSSHLSQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFG 60

Query: 61  AVRNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPV 120
           AVRNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPV
Sbjct: 61  AVRNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPV 120

Query: 121 IHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLR 180
           IHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLR
Sbjct: 121 IHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLR 180

Query: 181 SGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASS 240
           SGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASS
Sbjct: 181 SGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASS 240

Query: 241 LPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNS 300
           LPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNS
Sbjct: 241 LPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNS 300

Query: 301 QETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDA 360
           QETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDA
Sbjct: 301 QETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDA 360

Query: 361 EQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVN 420
           EQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVN
Sbjct: 361 EQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVN 420

Query: 421 NELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDYAAVA 476
           NELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDYAAVA
Sbjct: 421 NELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDYAAVA 476


>gi|150456471 doublecortin domain containing 2B [Homo sapiens]
          Length = 349

 Score =  196 bits (497), Expect = 5e-50
 Identities = 125/338 (36%), Positives = 182/338 (53%), Gaps = 19/338 (5%)

Query: 14  PVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAVRNIYTPRTGHR 73
           P  K V+VYRNGDPF+ G ++V+ +++  + E FL EVT  VQAP  AVR +YTP  GH 
Sbjct: 6   PAAKRVVVYRNGDPFFPGSQLVVTQRRFPTMEAFLCEVTSAVQAPL-AVRALYTPCHGHP 64

Query: 74  IRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPVIHSRINVSARFRK 133
           +  L  +++ G YVA G E F KL+YL     K    +    +  PV     + +   + 
Sbjct: 65  VTNLADLKNRGQYVAAGFERFHKLHYLP-HRGKDPGGKSCRLQGPPVTRHLCDGAIGRQL 123

Query: 134 PLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGK 193
           P   P  I +  NGDL++P   L + +     W+ VL+++TEK+ L+SGAV +L TLEG 
Sbjct: 124 PAGAPSYIHVFRNGDLVSPPFSLKLSQAASQDWETVLKLLTEKVKLQSGAVCKLCTLEGL 183

Query: 194 LVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGS 253
            + +G EL  G +YVAVG D+FK LPY ELL    ++ R   Q     PP  GS+     
Sbjct: 184 PLSAGKELVTGHYYVAVGEDEFKDLPYLELLVPSPSLPRGCWQ-----PP--GSKSRPHR 236

Query: 254 GNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETI--PNSDEGI 311
              +  ++ V       P  +K         S    + +Q ++ ++   T+  P+   G+
Sbjct: 237 QGAQGHRAQVTQPSPKEPDRIK--------PSAFYARPQQTIQPRSKLPTLSFPSGVIGV 288

Query: 312 FKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDE 349
           + A   R ET GA EV +DEDTQ E P+DQR A+IV+E
Sbjct: 289 YGAPHRRKETAGALEVADDEDTQTEEPLDQRAAQIVEE 326


>gi|239753110 PREDICTED: doublecortin domain-containing protein
           ENSP00000382097-like [Homo sapiens]
          Length = 530

 Score =  186 bits (471), Expect = 5e-47
 Identities = 116/357 (32%), Positives = 192/357 (53%), Gaps = 26/357 (7%)

Query: 3   GSSARSSHLSQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAV 62
           G+   S+ +     K+++VYRNGDPFY G++ V+  ++ ++FE  L+++T  V  PFG V
Sbjct: 72  GTRGPSAPVDTTPAKTIVVYRNGDPFYVGKKFVLSRRRAATFEALLEQLTEQVDVPFG-V 130

Query: 63  RNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVN-TEVKPVI 121
           R ++TP  GHR+  LD +Q+GG YVA G+E FK+L+Y+ I  + ++P ++    E+KPV+
Sbjct: 131 RRLFTPTRGHRVLGLDALQAGGKYVAAGRERFKELDYIHI--VPRKPAKIRKLKEIKPVV 188

Query: 122 HSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRS 181
           H  INV ++++   +    I +  NG L  P ++++IP+ +L+ WD VL  + EK+    
Sbjct: 189 HCDINVPSKWQTYHRISRHINVFTNGRLFIPPAKIIIPKFSLSDWDIVLATIGEKV-FPL 247

Query: 182 GAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPY----------------SELLF 225
           G V +L+T+ G L+    +L++  FYVAVG + FK  PY                   LF
Sbjct: 248 GGVRKLFTMNGHLLGDSKDLQDNHFYVAVGLETFKYFPYWKSPRVPSEVQHVSGVKSYLF 307

Query: 226 DKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNS 285
              T   P  Q  S  P    S + + +     ++  V   D+   +P K  G       
Sbjct: 308 HSLTEHSPRRQAPS--PFYRTSERPETTQLTWRARDPV-LVDSKGKEPCKYDGIPPK-TQ 363

Query: 286 EKLTKLKQNVKLKNSQETIPNSDEG-IFKAGAERSETRGAAEVQEDEDTQVEVPVDQ 341
           + +   K+  K   ++  +    EG ++KA     ET+GA +V+E+ + Q+EVPVDQ
Sbjct: 364 DSVYYAKEEKKKTLAEPLVQRGAEGDVYKAPTPSKETQGALDVKEEHNVQLEVPVDQ 420


>gi|239747673 PREDICTED: doublecortin domain-containing protein
           ENSP00000382097-like [Homo sapiens]
          Length = 714

 Score =  182 bits (463), Expect = 4e-46
 Identities = 128/410 (31%), Positives = 204/410 (49%), Gaps = 60/410 (14%)

Query: 3   GSSARSSHLSQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAV 62
           G+   S+ +     K+++VYRNGDPFY G++ V+  ++ ++FE  L+++T  V  PFG V
Sbjct: 178 GTRGPSAPVDTTPAKTIVVYRNGDPFYVGKKFVLSRRRAATFEALLEQLTEQVDVPFG-V 236

Query: 63  RNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVN-TEVKPVI 121
           R ++TP  GHR+  LD +Q+GG YVA G+E FK+L+Y+ I  + ++P ++    E+KPV+
Sbjct: 237 RRLFTPTRGHRVLGLDALQAGGKYVAAGRERFKELDYIHI--VPRKPAKIRKLKEIKPVV 294

Query: 122 HSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRS 181
           H  INV ++++   +    I +  NG L  P ++++IP+ +L+ WD VL  + EK+    
Sbjct: 295 HCDINVPSKWQTYHRISRHINVFTNGRLFIPPAKIIIPKFSLSDWDIVLATIGEKV-FPL 353

Query: 182 GAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSL 241
           G V +L+T+ G L+    +L++  FYVAVG + FK  PY +     S  + P   K   +
Sbjct: 354 GGVRKLFTMNGHLLGDSKDLQDNHFYVAVGLETFKYFPYWKSPRVDSKGKEPC--KYDGI 411

Query: 242 PPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQ 301
           PP       K   +  ++K        +  +PL ++G + DV                  
Sbjct: 412 PP-------KTQDSVYYAKE---EKKKTLAEPLVQRGAEGDV------------------ 443

Query: 302 ETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEE---DGEKANK 358
                     +KA     ET+GA +V+E+ + Q+EVPVDQ     V   E    GE A  
Sbjct: 444 ----------YKAPTPSKETQGALDVKEEHNVQLEVPVDQSWTGWVAASEWAKPGELARA 493

Query: 359 -DAEQKEDFSG-----------MNGDLEEEGGREATDAPEQVEEILDHSE 396
             A       G             GD    G REA+  PE      +H+E
Sbjct: 494 WLAAWPHSAPGPCCLLGRLLALRQGDWHTHGHREASPMPESFWLAYEHTE 543


>gi|239741542 PREDICTED: doublecortin domain-containing protein
           ENSP00000382097-like [Homo sapiens]
          Length = 510

 Score =  182 bits (461), Expect = 8e-46
 Identities = 111/340 (32%), Positives = 184/340 (54%), Gaps = 45/340 (13%)

Query: 3   GSSARSSHLSQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAV 62
           G+   S+ +     K+++VYRNGDPFY G++ V+  ++ ++FE  L+++T  V  PFG V
Sbjct: 178 GTRGPSAPVDTTPAKTIVVYRNGDPFYVGKKFVLSRRRAATFEALLEQLTEQVDVPFG-V 236

Query: 63  RNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVN-TEVKPVI 121
           R ++TP  GHR+  LD +Q+GG YVA G+E FK+L+Y+ I  + ++P ++    E+KPV+
Sbjct: 237 RRLFTPTRGHRVLGLDALQAGGKYVAAGRERFKELDYIHI--VPRKPAKIRKLKEIKPVV 294

Query: 122 HSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRS 181
           H  INV ++++   +    I +  NG L  P ++++IP+ +L+ WD VL  + EK+    
Sbjct: 295 HCDINVPSKWQTYHRISRHINVFTNGRLFIPPAKIIIPKFSLSDWDIVLATIGEKV-FPL 353

Query: 182 GAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSL 241
           G V +L+T+ G L+    +L++  FYVAVG + FK  PY +     S  + P   K   +
Sbjct: 354 GGVRKLFTMNGHLLGDSKDLQDNHFYVAVGLETFKYFPYWKSPRVDSKGKEPC--KYDGI 411

Query: 242 PPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQ 301
           PP       K   +  ++K        +  +PL ++G + DV                  
Sbjct: 412 PP-------KTQDSVYYAKE---EKKKTLAEPLVQRGAEGDV------------------ 443

Query: 302 ETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQ 341
                     +KA     ET+GA +V+E+ + Q+EVPVDQ
Sbjct: 444 ----------YKAPTPSKETQGALDVKEEHNVQLEVPVDQ 473


>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
          Length = 729

 Score =  103 bits (256), Expect = 4e-22
 Identities = 102/348 (29%), Positives = 149/348 (42%), Gaps = 27/348 (7%)

Query: 12  SQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVT----GGVQAPFGAVRNIYT 67
           S+   K V  YRNGD ++ G    I   +  SFE  L ++T      V  P G VR IYT
Sbjct: 52  SEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQG-VRTIYT 110

Query: 68  PRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPVIHSRINV 127
                +I  LDQ+  G +YV G  E FKKL Y          + V  T     + S    
Sbjct: 111 IDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTK-NVNPNWSVNVKTTSASRAVSSLATA 169

Query: 128 SA-----RFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSG 182
                  R  K    P  + +I +G     A R+L+ +KT + ++ VL  +T+ I L SG
Sbjct: 170 KGSPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSG 229

Query: 183 AVHRLYTLEGKLVESGAE-LENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSL 241
            V RLYTL+GK V    +   +   ++A G +KF+     + L D+S  R     K++S 
Sbjct: 230 VVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRY--QDDFLLDESECR---VVKSTSY 284

Query: 242 PPIVGSRK---SKGSGNDRHSKSTVG-SSDNSSP---QPLKRKGKKEDVNSEKLTKLKQN 294
             I  S +   +K  G  R SKS    SS N +P       R GK    +      L+  
Sbjct: 285 TKIASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLR-- 342

Query: 295 VKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQR 342
            K ++SQ    ++     K  +   E  G  E   +E  Q+   + +R
Sbjct: 343 -KQRSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQIPATITER 389


>gi|30181244 doublecortin isoform c [Homo sapiens]
          Length = 360

 Score = 95.5 bits (236), Expect = 9e-20
 Identities = 80/282 (28%), Positives = 123/282 (43%), Gaps = 25/282 (8%)

Query: 17  KSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVT----GGVQAPFGAVRNIYTPRTGH 72
           K V  YRNGD ++ G    +   +  SF+  L ++T      +  P G VR IYT     
Sbjct: 53  KKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQG-VRYIYTIDGSR 111

Query: 73  RIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKP------VIHSRIN 126
           +I  +D+++ G +YV      FKK+ Y         P   VN +          + S  +
Sbjct: 112 KIGSMDELEEGESYVCSSDNFFKKVEYTK----NVNPNWSVNVKTSANMKAPQSLASSNS 167

Query: 127 VSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHR 186
             AR  K    P  + +I +G     A R+L+ +KT + ++ VL  +TE I L +G V +
Sbjct: 168 AQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKK 227

Query: 187 LYTLEGKLVESGAE-LENGQFYVAVGRDKFK------KLPYSELLFDKSTMRRPFGQKAS 239
           LYTL+GK V    +   +   ++A G +KF+       L  +E    K       G KAS
Sbjct: 228 LYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKAS 287

Query: 240 SLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKE 281
             P       +K  G  R SKS   S++ +S   L     K+
Sbjct: 288 PTPQ---KTSAKSPGPMRRSKSPADSANGTSSSQLSTPKSKQ 326


>gi|30181240 doublecortin isoform c [Homo sapiens]
          Length = 360

 Score = 95.5 bits (236), Expect = 9e-20
 Identities = 80/282 (28%), Positives = 123/282 (43%), Gaps = 25/282 (8%)

Query: 17  KSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVT----GGVQAPFGAVRNIYTPRTGH 72
           K V  YRNGD ++ G    +   +  SF+  L ++T      +  P G VR IYT     
Sbjct: 53  KKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQG-VRYIYTIDGSR 111

Query: 73  RIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKP------VIHSRIN 126
           +I  +D+++ G +YV      FKK+ Y         P   VN +          + S  +
Sbjct: 112 KIGSMDELEEGESYVCSSDNFFKKVEYTK----NVNPNWSVNVKTSANMKAPQSLASSNS 167

Query: 127 VSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHR 186
             AR  K    P  + +I +G     A R+L+ +KT + ++ VL  +TE I L +G V +
Sbjct: 168 AQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKK 227

Query: 187 LYTLEGKLVESGAE-LENGQFYVAVGRDKFK------KLPYSELLFDKSTMRRPFGQKAS 239
           LYTL+GK V    +   +   ++A G +KF+       L  +E    K       G KAS
Sbjct: 228 LYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKAS 287

Query: 240 SLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKE 281
             P       +K  G  R SKS   S++ +S   L     K+
Sbjct: 288 PTPQ---KTSAKSPGPMRRSKSPADSANGTSSSQLSTPKSKQ 326


>gi|30181246 doublecortin isoform a [Homo sapiens]
          Length = 441

 Score = 95.5 bits (236), Expect = 9e-20
 Identities = 80/282 (28%), Positives = 123/282 (43%), Gaps = 25/282 (8%)

Query: 17  KSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVT----GGVQAPFGAVRNIYTPRTGH 72
           K V  YRNGD ++ G    +   +  SF+  L ++T      +  P G VR IYT     
Sbjct: 134 KKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQG-VRYIYTIDGSR 192

Query: 73  RIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKP------VIHSRIN 126
           +I  +D+++ G +YV      FKK+ Y         P   VN +          + S  +
Sbjct: 193 KIGSMDELEEGESYVCSSDNFFKKVEYTK----NVNPNWSVNVKTSANMKAPQSLASSNS 248

Query: 127 VSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHR 186
             AR  K    P  + +I +G     A R+L+ +KT + ++ VL  +TE I L +G V +
Sbjct: 249 AQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKK 308

Query: 187 LYTLEGKLVESGAE-LENGQFYVAVGRDKFK------KLPYSELLFDKSTMRRPFGQKAS 239
           LYTL+GK V    +   +   ++A G +KF+       L  +E    K       G KAS
Sbjct: 309 LYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKAS 368

Query: 240 SLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKE 281
             P       +K  G  R SKS   S++ +S   L     K+
Sbjct: 369 PTPQ---KTSAKSPGPMRRSKSPADSANGTSSSQLSTPKSKQ 407


>gi|30181242 doublecortin isoform b [Homo sapiens]
          Length = 365

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 81/282 (28%), Positives = 125/282 (44%), Gaps = 32/282 (11%)

Query: 17  KSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVT----GGVQAPFGAVRNIYTPRTGH 72
           K V  YRNGD ++ G    +   +  SF+  L ++T      +  P G VR IYT     
Sbjct: 53  KKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQG-VRYIYTIDGSR 111

Query: 73  RIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKP------VIHSRIN 126
           +I  +D+++ G +YV      FKK+ Y         P   VN +          + S  +
Sbjct: 112 KIGSMDELEEGESYVCSSDNFFKKVEYTK----NVNPNWSVNVKTSANMKAPQSLASSNS 167

Query: 127 VSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHR 186
             AR  K    P  + +I +G     A R+L+ +KT + ++ VL  +TE I L +G V +
Sbjct: 168 AQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKK 227

Query: 187 LYTLEGKLVESGAE-LENGQFYVAVGRDKFK------KLPYSELLFDKSTMRRPFGQKAS 239
           LYTL+GK V    +   +   ++A G +KF+       L  +E    K       G KAS
Sbjct: 228 LYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKAS 287

Query: 240 SLP---------PIVGSRKSKGSGNDRHSKSTVGSSDNSSPQ 272
             P         P+  S+    SGND+ +  T  SS  S+P+
Sbjct: 288 PTPQKTSAKSPGPMRRSKSPADSGNDQDANGT-SSSQLSTPK 328


>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
          Length = 765

 Score = 92.4 bits (228), Expect = 8e-19
 Identities = 91/329 (27%), Positives = 138/329 (41%), Gaps = 39/329 (11%)

Query: 12  SQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVT----GGVQAPFGAVRNIYT 67
           S+   K    YRNGD ++ G    I   +  SF+  L E+T      V  P G VR IYT
Sbjct: 67  SEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQG-VRTIYT 125

Query: 68  PRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVN----TEVKPVIHS 123
                ++  LD++  G +YV    E F+K++Y         P   VN    T       S
Sbjct: 126 IDGSRKVTSLDELLEGESYVCASNEPFRKVDYTK----NINPNWSVNIKGGTSRALAAAS 181

Query: 124 RINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGA 183
            +    +  K   +P  + +I +G     A R+L+ +KT + ++ VL  +TE I L SG 
Sbjct: 182 SVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGV 241

Query: 184 VHRLYTLEGKLVESGAE-LENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLP 242
           V RL TL+GK V    +   +   ++A G +KF +    + + D S  R           
Sbjct: 242 VKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKF-RYAQDDFVLDHSECR----------- 289

Query: 243 PIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLK--QNVKLKNS 300
            ++ S  S+         S V  S + SP P +R      VN    ++L   ++ K  +S
Sbjct: 290 -VLKSSYSR--------SSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSS 340

Query: 301 QETIPNSDEG--IFKAGAERSETRGAAEV 327
             T P S  G  I   G   S   G  E+
Sbjct: 341 SPTSPGSFRGLKISAHGRSSSNVNGGPEL 369


>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
          Length = 766

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 84/281 (29%), Positives = 124/281 (44%), Gaps = 24/281 (8%)

Query: 12  SQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVT----GGVQAPFGAVRNIYT 67
           S+   K    YRNGD ++ G    I   +  SF+  L E+T      V  P G VR IYT
Sbjct: 67  SEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQG-VRTIYT 125

Query: 68  PRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVN----TEVKPVIHS 123
                ++  LD++  G +YV    E F+K++Y         P   VN    T       S
Sbjct: 126 IDGSRKVTSLDELLEGESYVCASNEPFRKVDYTK----NINPNWSVNIKGGTSRALAAAS 181

Query: 124 RINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGA 183
            +    +  K   +P  + +I +G     A R+L+ +KT + ++ VL  +TE I L SG 
Sbjct: 182 SVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGV 241

Query: 184 VHRLYTLEGKLVESGAE-LENGQFYVAVGRDKFK------KLPYSELLFDKSTMRRPFGQ 236
           V RL TL+GK V    +   +   ++A G +KF+       L +SE    KS+  R    
Sbjct: 242 VKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAV 301

Query: 237 KASSLPPIVGSRKSKG----SGNDRHSKSTVGSSDNSSPQP 273
           K S       SR+SK     +G      ST  S+ +SS  P
Sbjct: 302 KYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSP 342


>gi|5454016 retinitis pigmentosa RP1 protein [Homo sapiens]
          Length = 2156

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 63/214 (29%), Positives = 110/214 (51%), Gaps = 14/214 (6%)

Query: 7   RSSHLSQPVV-KSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAVRNI 65
           R   L+ PVV K +  Y++GDP + G RVV++ +   SF+  L  ++  V  PFG VRNI
Sbjct: 25  RHLSLTHPVVAKRISFYKSGDPQFGGVRVVVNPRSFKSFDALLDNLSRKVPLPFG-VRNI 83

Query: 66  YTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPVIHSRI 125
            TPR  H I +L++++ G +Y+       +K+  +D+ + ++RP   +++          
Sbjct: 84  STPRGRHSITRLEELEDGESYLCSHG---RKVQPVDLDKARRRPRPWLSSRAISAHSPPH 140

Query: 126 NVSARFRKPLQEPCTIFLIANGDLINPASR--LLIPRKTLNQWDHVLQMVTEKITLRSGA 183
            V+       + P ++ +  NGD   P +R  +L+ R+    ++  LQ +TE   +    
Sbjct: 141 PVAVAAPGMPRPPRSLVVFRNGD---PKTRRAVLLSRRVTQSFEAFLQHLTE---VMQRP 194

Query: 184 VHRLYTLEGKLVES-GAELENGQFYVAVGRDKFK 216
           V +LY  +G+ V S  A + +    VA GR+ FK
Sbjct: 195 VVKLYATDGRRVPSLQAVILSSGAVVAAGREPFK 228


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 69/265 (26%), Positives = 113/265 (42%), Gaps = 28/265 (10%)

Query: 17  KSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRK 76
           K +   + GDP +AG R+ +H++   +F   + E++  V   FG VR++ TPR  H +  
Sbjct: 34  KKITFLKRGDPRFAGVRLAVHQRAFKTFSALMDELSQRVPLSFG-VRSVTTPRGLHSLSA 92

Query: 77  LDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPVIHSR-INVSARFRKPL 135
           L+Q++ GG Y+       KK      G  + +       +++ V   R    ++  RK L
Sbjct: 93  LEQLEDGGCYLCSD----KKPPKTPSGPGRPQERNPTAQQLRDVEGQREAPGTSSSRKSL 148

Query: 136 QEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLV 195
           + P  I LI N D     + +L  R T N    +   + +   L    V +LYT  GK V
Sbjct: 149 KTPRRILLIKNMDPRLQQTVVLSHRNTRN----LAAFLGKASDLLRFPVKQLYTTSGKKV 204

Query: 196 ES-GAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSG 254
           +S  A L +    V  G + F+             M+     +A +L  +  SR   GS 
Sbjct: 205 DSLQALLHSPSVLVCAGHEAFR----------TPAMKNARRSEAETLSGLT-SRNKNGSW 253

Query: 255 NDR------HSKSTVGSSDNSSPQP 273
             +      HS+S  GS+     +P
Sbjct: 254 GPKTKPSVIHSRSPPGSTPRLPERP 278



 Score = 37.7 bits (86), Expect = 0.023
 Identities = 43/210 (20%), Positives = 84/210 (40%), Gaps = 18/210 (8%)

Query: 267  DNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAE 326
            +  S + L+ +G+ E  +     +  +    +   +T P S+       ++ +E     E
Sbjct: 1918 ETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEV----IESQEAEEEAQPE 1973

Query: 327  VQEDEDTQVEVPVDQRPAEIVDEEEDGE--KANKDAEQKEDFSGMNGDLEEEGGREATDA 384
             ++ E  +VEV   +   E   E ED E  +A  + ++ E+ +    D  E   +   + 
Sbjct: 1974 SEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEE 2033

Query: 385  PEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEAD 444
             ++VE     +E  A+P        E +G E  +   E Q    + ++++G    + E D
Sbjct: 2034 AQEVEGETQKTEGDAQP--------ESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESE-D 2084

Query: 445  VDPQR---PPRPEVKITSPEENENNQQNKD 471
            VD Q      +PE +     E E   Q  +
Sbjct: 2085 VDAQEAEGEAQPESEGVEAPEAEGEAQKAE 2114



 Score = 36.6 bits (83), Expect = 0.051
 Identities = 48/220 (21%), Positives = 82/220 (37%), Gaps = 27/220 (12%)

Query: 254  GNDRHSKSTVGSSDNSSPQP---LKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEG 310
            G   +S+++ GS    + Q    +  +G+     S     L+        Q+  P   +G
Sbjct: 1774 GKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQD--PGQSDG 1831

Query: 311  IFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAE-QKEDFSGM 369
                G E  E  G A+    E   VE P         + E D ++A  +A+ + ED    
Sbjct: 1832 A--EGIEAPEAEGEAQ---PESEGVEAP---------EAEGDAQEAEGEAQPESEDVEAP 1877

Query: 370  NGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDK 429
              + E +   E  + PE   E+   SE    P        E    E  +   E       
Sbjct: 1878 EAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGE------D 1931

Query: 430  ERKSQGAGSGQ-DEADVDPQRPPRPEVKITSPEENENNQQ 468
            E +S+GA + + +EA  + +   +PE ++   +E E   Q
Sbjct: 1932 EPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQ 1971



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 37/162 (22%), Positives = 56/162 (34%), Gaps = 12/162 (7%)

Query: 302  ETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAE 361
            E  P S EGI    AE  E +  +E  E +D + E   +    E  + EE+ +   +  E
Sbjct: 2124 EAQPES-EGIEAPEAE-GEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVE 2181

Query: 362  ----------QKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEE 411
                      + E       + E +   E  +APE  EE     E    P        E 
Sbjct: 2182 APEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPES 2241

Query: 412  NGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRP 453
             GE   +     Q+ L   +  + + S     +  P  PP P
Sbjct: 2242 EGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSP 2283



 Score = 33.5 bits (75), Expect = 0.43
 Identities = 38/161 (23%), Positives = 60/161 (37%), Gaps = 21/161 (13%)

Query: 328  QEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQ 387
            Q D    +E P  +  A+   E  +  +A  DA++ E      G+ + E   E  +APE 
Sbjct: 1828 QSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAE------GEAQPES--EDVEAPEA 1879

Query: 388  VEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQ--------LVLDKERKSQGAGSG 439
              E    SE    P        E  G E  +   E Q        L  + E + +  G+ 
Sbjct: 1880 EGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAE 1939

Query: 440  QDEA-----DVDPQRPPRPEVKITSPEENENNQQNKDYAAV 475
              EA     + + Q  P  EV  +   E E   +++D  A+
Sbjct: 1940 AQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL 1980



 Score = 33.1 bits (74), Expect = 0.57
 Identities = 38/161 (23%), Positives = 70/161 (43%), Gaps = 25/161 (15%)

Query: 284  NSEKLTK--LKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQ 341
            N E+L +  +++ V+L+ ++E      EG+ +   +  ET+    +QE E  Q+E     
Sbjct: 1288 NLEQLAENTVQEEVQLEETKEG--TEGEGLQEEAVQLEETKTEEGLQE-EGVQLEET--- 1341

Query: 342  RPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARP 401
                   +E +GE   ++  Q E+       +EE GG    +   Q+EE+ +  E   + 
Sbjct: 1342 -------KETEGEGQQEEEAQLEE-------IEETGGEGLQEEGVQLEEVKEGPEGGLQG 1387

Query: 402  ARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDE 442
              +  G  EE   E   V+ +    L +     G GS +D+
Sbjct: 1388 EALEEGLKEEGLPEEGSVHGQ---ELSEASSPDGKGSQEDD 1425


>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
           sapiens]
          Length = 1101

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 54/207 (26%), Positives = 92/207 (44%), Gaps = 27/207 (13%)

Query: 241 LPPIVGSRKS--KGSGNDRHSKSTVGSSDNSSPQPLKRKGKKE---DVNSEKLTKLKQNV 295
           L P++G +    KGSG      S  G +     Q L + G+++   +V  +K  +    +
Sbjct: 616 LSPLLGPKPPIWKGSG------SLEGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGGRL 669

Query: 296 KLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEK 355
            ++   E  P +     KA  +R E  G+ E      T+V +    R      EE + ++
Sbjct: 670 DIREEAEGSPETKVEAGKASEDRGEAGGSQE------TKVRLREGSR------EETEAKE 717

Query: 356 ANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEE 415
                ++K D     G +EE GG E TD  E+ +EI    ++Q   A+V  G D E G +
Sbjct: 718 EKSKGQKKADSMEAKG-VEEPGGDEYTD--EKEKEIEREEDEQREEAQVEAGRDLEQGAQ 774

Query: 416 LQQVNNELQLVLDKERKSQGAGSGQDE 442
             QV  E   V+ K+ +++G    +D+
Sbjct: 775 EDQVAEEKWEVVQKQ-EAEGVREDEDK 800


>gi|157738619 smoothelin-like 1 [Homo sapiens]
          Length = 512

 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 46/210 (21%), Positives = 87/210 (41%), Gaps = 21/210 (10%)

Query: 259 SKSTVGSSDNSSPQPLKRKGKKED--VNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGA 316
           S+   G  +++  +  K  G+KE+  V S+++T  K+  K +  +     S     K  A
Sbjct: 98  SQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKA 157

Query: 317 ERSETRGA----AEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGD 372
           E  E +      A+  + +  + +  V++  A+   +EE G++     E KE  +     
Sbjct: 158 EEKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKAT----- 212

Query: 373 LEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERK 432
            +EE   E+  A  + E   +  E   +    +G  +E + +E  +         D E  
Sbjct: 213 -DEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAE---------DAEEA 262

Query: 433 SQGAGSGQDEADVDPQRPPRPEVKITSPEE 462
             G+ S + E DV+ +      V  +SPEE
Sbjct: 263 EPGSPSEEQEQDVEKEPEGGAGVIPSSPEE 292



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 57/243 (23%), Positives = 91/243 (37%), Gaps = 27/243 (11%)

Query: 235 GQKASSLPPIVGSRKSKGSGNDRHSKSTVGSS---DNSSPQPLKRKGKKEDVNSEKLTKL 291
           G+  +  PP    ++ K    D  S    G +   D    +  +  G KED  +E    L
Sbjct: 57  GKAINEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAE----L 112

Query: 292 KQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEE 351
           K+    K  +ET   S E   +    +SE +   E +E E T       Q+  E   + E
Sbjct: 113 KKEDGEK--EETTVGSQEMTGRKEETKSEPK---EAEEKESTLASEK--QKAEEKEAKPE 165

Query: 352 DGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEE 411
            G+KA+ +   K +       +EEE  + A+      EE     E    P      TDEE
Sbjct: 166 SGQKADANDRDKPE---PKATVEEEDAKTASQ-----EETGQRKECSTEPKEK--ATDEE 215

Query: 412 NGEELQQVNNELQLVLDKER---KSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQ 468
              E Q+   E +   + +    K +     ++EAD   +     E +  SP E +    
Sbjct: 216 AKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDV 275

Query: 469 NKD 471
            K+
Sbjct: 276 EKE 278



 Score = 36.2 bits (82), Expect = 0.067
 Identities = 46/197 (23%), Positives = 75/197 (38%), Gaps = 13/197 (6%)

Query: 280 KEDVNSEKLTKLKQNV-KLKNSQETI-PNSDEGIFKAG-AERSETRGAAEVQEDEDTQVE 336
           + D ++E   K++Q   KL     T+ P +D      G A   ET+G A    +E    E
Sbjct: 8   ESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTE 67

Query: 337 VPVDQR-PAEI-VDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDH 394
               ++ PAE  +  E  GE    D  + E          E GG+E  +A E  +E  + 
Sbjct: 68  SGKQEKAPAEDGMSAELQGEANGLDEVKVES-------QREAGGKEDAEA-ELKKEDGEK 119

Query: 395 SEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRPE 454
            E       + G  +E   E  +    E  L  +K++  +     +     D     +PE
Sbjct: 120 EETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPE 179

Query: 455 VKITSPEENENNQQNKD 471
            K T  EE+      ++
Sbjct: 180 PKATVEEEDAKTASQEE 196


>gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]
          Length = 755

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 44/198 (22%), Positives = 90/198 (45%), Gaps = 18/198 (9%)

Query: 247 SRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPN 306
           S K    G++R  +      +N   + L  +G +++++   L K  +    +NS+     
Sbjct: 553 SEKQSEDGSEREFE------ENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDG 606

Query: 307 SDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDF 366
           S++ + + G+ER     + E +E+EDT  +V  D+      DE+ED E A++   +  D 
Sbjct: 607 SEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDES-----DEKEDEEYADEKGLEAADK 661

Query: 367 SGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEEL--QQVNNELQ 424
               GD +E+   E+ D  ++     D   ++   A      D+++ E+L  ++ ++  +
Sbjct: 662 KAEEGDADEKLFEESDDKEDE-----DADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEK 716

Query: 425 LVLDKERKSQGAGSGQDE 442
           L  D + +    G G  E
Sbjct: 717 LFDDSDERGTLGGFGSVE 734



 Score = 37.7 bits (86), Expect = 0.023
 Identities = 37/172 (21%), Positives = 73/172 (42%), Gaps = 36/172 (20%)

Query: 264 GSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRG 323
           GS ++S  +  K+K  K D     L K  ++   K S+E +                  G
Sbjct: 493 GSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEV------------------G 534

Query: 324 AAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKE-DFSGMNGDLEEEGGREAT 382
             +  E++D++ E            +E+  EK ++D  ++E + +G+  DL+EEG  +  
Sbjct: 535 PTKESEEDDSEKE-----------SDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEK-- 581

Query: 383 DAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQ 434
              E  E +LD  E +   +  +   D+ + + L +  +E +   D + K +
Sbjct: 582 ---ELHENVLD-KELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEE 629


>gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens]
          Length = 755

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 44/198 (22%), Positives = 90/198 (45%), Gaps = 18/198 (9%)

Query: 247 SRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPN 306
           S K    G++R  +      +N   + L  +G +++++   L K  +    +NS+     
Sbjct: 553 SEKQSEDGSEREFE------ENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDG 606

Query: 307 SDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDF 366
           S++ + + G+ER     + E +E+EDT  +V  D+      DE+ED E A++   +  D 
Sbjct: 607 SEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDES-----DEKEDEEYADEKGLEAADK 661

Query: 367 SGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEEL--QQVNNELQ 424
               GD +E+   E+ D  ++     D   ++   A      D+++ E+L  ++ ++  +
Sbjct: 662 KAEEGDADEKLFEESDDKEDE-----DADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEK 716

Query: 425 LVLDKERKSQGAGSGQDE 442
           L  D + +    G G  E
Sbjct: 717 LFDDSDERGTLGGFGSVE 734



 Score = 37.7 bits (86), Expect = 0.023
 Identities = 37/172 (21%), Positives = 73/172 (42%), Gaps = 36/172 (20%)

Query: 264 GSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRG 323
           GS ++S  +  K+K  K D     L K  ++   K S+E +                  G
Sbjct: 493 GSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEV------------------G 534

Query: 324 AAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKE-DFSGMNGDLEEEGGREAT 382
             +  E++D++ E            +E+  EK ++D  ++E + +G+  DL+EEG  +  
Sbjct: 535 PTKESEEDDSEKE-----------SDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEK-- 581

Query: 383 DAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQ 434
              E  E +LD  E +   +  +   D+ + + L +  +E +   D + K +
Sbjct: 582 ---ELHENVLD-KELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEE 629


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 47/183 (25%), Positives = 82/183 (44%), Gaps = 18/183 (9%)

Query: 279 KKEDVNSEK---LTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQV 335
           K ED  SE    LT + + + +   +E          K  AE  E    AE  E+E    
Sbjct: 461 KVEDEKSEMEEALTAITEELAVSMKEEK---------KEAAEEKEEEPEAE--EEEVAAK 509

Query: 336 EVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGG--REATDAPEQVEEILD 393
           + PV     E+ +EE + E+     E++E+  G   D  EEGG  +E +   E+ E+   
Sbjct: 510 KSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEG 569

Query: 394 HSEQQARPARVNGGTDEENGEELQQVNNELQLVLD-KERKSQGAGSGQDEADVDPQ-RPP 451
            +E +A         +++  E+ ++V  + +LV D K  K + A S   ++ V+ + + P
Sbjct: 570 ETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSP 629

Query: 452 RPE 454
            P+
Sbjct: 630 VPK 632



 Score = 37.4 bits (85), Expect = 0.030
 Identities = 43/214 (20%), Positives = 88/214 (41%), Gaps = 18/214 (8%)

Query: 247 SRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDV-NSEKLT---KLKQNVKLKNSQE 302
           S K +G   +  +++     +  + +  K + K E+V   E+L    K+++  K K+   
Sbjct: 559 SEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVP 618

Query: 303 TIPNSDEGIFKAGAERSETRGAAEV------QEDEDTQVEVPVDQRPAEIVDEEEDGEKA 356
             P  ++G         E +G + V      ++ +    + PV+++    V +    EKA
Sbjct: 619 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKA 678

Query: 357 NKDA------EQKEDFSGMNGDLEEEGGREATDAP--EQVEEILDHSEQQARPARVNGGT 408
                     E K       G+ +EE  +E  +AP  E+VE+  +  +      +     
Sbjct: 679 KSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPV 738

Query: 409 DEENGEELQQVNNELQLVLDKERKSQGAGSGQDE 442
            EE   E+  +   +++ L+KE K +G    Q++
Sbjct: 739 KEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEK 772


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 47/183 (25%), Positives = 82/183 (44%), Gaps = 18/183 (9%)

Query: 279 KKEDVNSEK---LTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQV 335
           K ED  SE    LT + + + +   +E          K  AE  E    AE  E+E    
Sbjct: 85  KVEDEKSEMEEALTAITEELAVSMKEEK---------KEAAEEKEEEPEAE--EEEVAAK 133

Query: 336 EVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGG--REATDAPEQVEEILD 393
           + PV     E+ +EE + E+     E++E+  G   D  EEGG  +E +   E+ E+   
Sbjct: 134 KSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEG 193

Query: 394 HSEQQARPARVNGGTDEENGEELQQVNNELQLVLD-KERKSQGAGSGQDEADVDPQ-RPP 451
            +E +A         +++  E+ ++V  + +LV D K  K + A S   ++ V+ + + P
Sbjct: 194 ETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSP 253

Query: 452 RPE 454
            P+
Sbjct: 254 VPK 256



 Score = 37.4 bits (85), Expect = 0.030
 Identities = 43/214 (20%), Positives = 88/214 (41%), Gaps = 18/214 (8%)

Query: 247 SRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDV-NSEKLT---KLKQNVKLKNSQE 302
           S K +G   +  +++     +  + +  K + K E+V   E+L    K+++  K K+   
Sbjct: 183 SEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVP 242

Query: 303 TIPNSDEGIFKAGAERSETRGAAEV------QEDEDTQVEVPVDQRPAEIVDEEEDGEKA 356
             P  ++G         E +G + V      ++ +    + PV+++    V +    EKA
Sbjct: 243 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKA 302

Query: 357 NKDA------EQKEDFSGMNGDLEEEGGREATDAP--EQVEEILDHSEQQARPARVNGGT 408
                     E K       G+ +EE  +E  +AP  E+VE+  +  +      +     
Sbjct: 303 KSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPV 362

Query: 409 DEENGEELQQVNNELQLVLDKERKSQGAGSGQDE 442
            EE   E+  +   +++ L+KE K +G    Q++
Sbjct: 363 KEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEK 396


>gi|4557509 cylicin 2 [Homo sapiens]
          Length = 348

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 47/257 (18%), Positives = 109/257 (42%), Gaps = 23/257 (8%)

Query: 227 KSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSE 286
           K T       KA+ +      + ++    D  S+   G  D+   + ++ KGK+E ++++
Sbjct: 100 KPTRTVEVDSKAAEIGKKGEDKTTQKDTTDSESELKQGKKDSKKGKDIE-KGKEEKLDAK 158

Query: 287 KLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEI 346
           K +K  +    K       + DE   K GA++   +   +  + +D+  E        E 
Sbjct: 159 KDSKKGKKDAEKGKDSATESEDE---KGGAKKDNKKDKKDSNKGKDSATE-----SEGEK 210

Query: 347 VDEEEDGEKANKDAEQKEDFS------------GMNGDLEEEGGREATDAPEQVEEILDH 394
              E+D +K  KD+++ +D +              +G  +   G E+ DA +  +EI   
Sbjct: 211 GGTEKDSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKG 270

Query: 395 SEQQARPARVNGGT-DEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRP 453
            + + +P+  +  + D+   E  +    + + V  K+ + + A S +D A  + ++  + 
Sbjct: 271 KKDKKKPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEKESADSKKD-AKKNAKKDAKK 329

Query: 454 EVKITSPEENENNQQNK 470
           + K  + ++ + + + K
Sbjct: 330 DAKKNAKKDEKKDAKKK 346


>gi|217330641 IWS1 homolog [Homo sapiens]
          Length = 819

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 47/230 (20%), Positives = 96/230 (41%), Gaps = 6/230 (2%)

Query: 249 KSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKE-DVNSEKLTKLKQNVKLKNSQETIPNS 307
           K + S ++        +SD+ +    + K K E D +S++  K +      +S  +  + 
Sbjct: 296 KPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHM 355

Query: 308 DEGIFKAGAERSETRGAAEVQEDEDTQV--EVPVDQRPAEIVDEEEDGEKAN-KDAEQKE 364
           D   F +     E     ++  DED +   E  V +R A ++ + ED EKA+ K +    
Sbjct: 356 DRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVS 415

Query: 365 DFSGMNGDL--EEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNE 422
           D    + D   ++ G RE T A +  EE       +    +   G+D E+G E + +  +
Sbjct: 416 DADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIAD 475

Query: 423 LQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDY 472
           +      E + +  G  Q++ + +       E + +  ++N    ++ D+
Sbjct: 476 IFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDF 525



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 51/275 (18%), Positives = 106/275 (38%), Gaps = 37/275 (13%)

Query: 213 DKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQ 272
           D   + P    + D  +   P  Q + S        ++  S N+   K  +  S++  P 
Sbjct: 197 DSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPP 256

Query: 273 PLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIP-------NSDEGIFKAGAERSETRGAA 325
               + +  D  +E+L K     ++ +S+   P       + +E + K     SE+ G  
Sbjct: 257 ----RHQASDSENEELPK----PRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQ 308

Query: 326 E-VQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDA 384
           +    D +T+      Q+P    D++ D E   +D E + D    +  ++ +    +   
Sbjct: 309 KGPASDSETEDASRHKQKPES--DDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSS--- 363

Query: 385 PEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAG------S 438
                   D  E++ +  +++   DE+ GEE +    +  ++ D E + + +       S
Sbjct: 364 --------DSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVS 415

Query: 439 GQDEADVD--PQRPPRPEVKITSPEENENNQQNKD 471
             D++D D    +  + E  I S  E E  ++  D
Sbjct: 416 DADDSDSDAVSDKSGKREKTIASDSEEEAGKELSD 450



 Score = 37.4 bits (85), Expect = 0.030
 Identities = 49/232 (21%), Positives = 89/232 (38%), Gaps = 31/232 (13%)

Query: 265 SSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQE-----TIPNSDEGIFKAGAERS 319
           +SD+ + +P   K +  D  SE+L K    V    S+E        + +E + K     S
Sbjct: 195 ASDSENEEP--PKPRMSDSESEELPK--PQVSDSESEEPPRHQASDSENEELPKPRISDS 250

Query: 320 ETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANK--DAEQKEDFSGMNGDLEEEG 377
           E+      Q  +    E+P  +    I D E +    N+  D+E +E       D E EG
Sbjct: 251 ESEDPPRHQASDSENEELPKPR----ISDSESEDPPRNQASDSENEELPKPRVSDSESEG 306

Query: 378 GREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVL---------- 427
            ++   +  + E   D S  + +P   +    E  GE+ +  N+                
Sbjct: 307 PQKGPASDSETE---DASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSS 363

Query: 428 ---DKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDYAAVA 476
              ++E K Q   S +DE + + ++  + +  + S  E+E     K    V+
Sbjct: 364 DSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVS 415



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 50/246 (20%), Positives = 92/246 (37%), Gaps = 51/246 (20%)

Query: 243 PIVGSRKSKGSG----NDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLK 298
           P+   R S   G    N++HS S  GS +  S          E+  S++   L +   + 
Sbjct: 18  PVQDERDSGSDGEDDVNEQHSGSDTGSVERHS----------ENETSDREDGLPKGHHVT 67

Query: 299 NSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDE-------EE 351
           +S+   P +   +  + +E  E     +   + + + E P      E V++       EE
Sbjct: 68  DSENDEPLN---LNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEE 124

Query: 352 DGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEE 411
             +    D+E +E  +G   D E E   +   +  ++EE+      Q  PA     +D E
Sbjct: 125 TRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEEL------QKSPA-----SDSE 173

Query: 412 NGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRP----------PRPEVKITSPE 461
             + L+        + D E +        D  + +P +P          P+P+V  +  E
Sbjct: 174 TEDALK------PQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESE 227

Query: 462 ENENNQ 467
           E   +Q
Sbjct: 228 EPPRHQ 233



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 44/229 (19%), Positives = 92/229 (40%), Gaps = 16/229 (6%)

Query: 250 SKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKL-----KQNVKLKNSQETI 304
           S  S  + H K  + S ++      +++G++E V   K   L     ++    K S+  +
Sbjct: 362 SSDSEEEEHKKQKMDSDED------EKEGEEEKVAKRKAAVLSDSEDEEKASAKKSR-VV 414

Query: 305 PNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKE 364
            ++D+    A +++S  R      + E+   +   D++  E      D E  N++     
Sbjct: 415 SDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIA 474

Query: 365 DFSGMNGDLEEE---GGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNN 421
           D  G +GD EEE   G  +     E+ E  +  +E       +  G   +   + + +  
Sbjct: 475 DIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQ 534

Query: 422 ELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNK 470
             + +  K R+++  G+   +AD D       ++   + E+ + N Q K
Sbjct: 535 RKKSMSGKRRRNRDGGTFISDAD-DVVSAMIVKMNEAAEEDRQLNNQKK 582


>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
          Length = 282

 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 56/253 (22%), Positives = 109/253 (43%), Gaps = 40/253 (15%)

Query: 231 RRPFGQKASSLPPIVGSRKSKGSGNDRH--SKSTVGSSDNSSPQPLKRKGKKEDVNSEKL 288
           +R   + ++ L P+    K K + + R   +KS +   +  +      + K+E V  E  
Sbjct: 17  KRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDY 76

Query: 289 TKLKQNVKLK------NSQETIPNSDEGIFKA---GAERSETRGAAEVQEDEDTQVEVPV 339
            +  +N + K      + +E +   +E I  A   G E+ E   AAEV+ +E+ Q E   
Sbjct: 77  NENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAV-AAEVKNEEEDQKEDEE 135

Query: 340 DQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSE-QQ 398
           DQ        EE GE   +D ++K           EE G+E  +  E+ E+  +  + ++
Sbjct: 136 DQN-------EEKGEAGKEDKDEKG----------EEDGKEDKNGNEKGEDAKEKEDGKK 178

Query: 399 ARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKIT 458
               + NG   +E GE+ ++         +++RK  G G   ++      +    +VK+ 
Sbjct: 179 GEDGKGNGEDGKEKGEDEKE---------EEDRKETGDGKENEDGKEKGDKKEGKDVKVK 229

Query: 459 SPE-ENENNQQNK 470
             E E E+ ++++
Sbjct: 230 EDEKEREDGKEDE 242



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 41/183 (22%), Positives = 78/183 (42%), Gaps = 25/183 (13%)

Query: 279 KKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDE------D 332
           KKE V +E    +K   + +   E   N ++G  +AG E  + +G  + +ED+      +
Sbjct: 115 KKEAVAAE----VKNEEEDQKEDEEDQNEEKG--EAGKEDKDEKGEEDGKEDKNGNEKGE 168

Query: 333 TQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEIL 392
              E    ++  +     EDG++  +D +++ED        E E G+E  D  E  +  +
Sbjct: 169 DAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKV 228

Query: 393 DHSEQQARPARVN-GGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPP 451
              E++    + + GG +EE G+E + +            K +  G  +DE   D  +  
Sbjct: 229 KEDEKEREDGKEDEGGNEEEAGKEKEDL------------KEEEEGKEEDEIKEDDGKKE 276

Query: 452 RPE 454
            P+
Sbjct: 277 EPQ 279



 Score = 32.3 bits (72), Expect = 0.97
 Identities = 38/163 (23%), Positives = 67/163 (41%), Gaps = 17/163 (10%)

Query: 235 GQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVN-SEKLTKLKQ 293
           G+K  ++   V + +     ++       G +          +  KED N +EK    K+
Sbjct: 113 GEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKE 172

Query: 294 NVKLKNSQETIPNSDEGIFKAGAERSET----RGAAEVQED--------EDTQVEVPVDQ 341
               K  ++   N ++G  K   E+ E      G  +  ED        E   V+V  D+
Sbjct: 173 KEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDE 232

Query: 342 RPAEIVDEEEDG--EKANKDAEQ-KEDFSGMNGD-LEEEGGRE 380
           +  E   E+E G  E+A K+ E  KE+  G   D ++E+ G++
Sbjct: 233 KEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKK 275


>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
          Length = 709

 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 49/198 (24%), Positives = 82/198 (41%), Gaps = 21/198 (10%)

Query: 258 HSKSTVGSSDNSSPQPLKR----KGK-------KEDVNSEKLTKLK--QNVKLKNSQETI 304
           HS+  V    +SS    KR    KGK       +E   SE+  +L   + ++L +S    
Sbjct: 65  HSRQLVSKPLSSSVSNNKRIVSTKGKSATEYKNEEYQRSERNKRLDADRKIRLSSSASRE 124

Query: 305 PNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPA-------EIVDEEEDGEKAN 357
           P  ++       +R   R A     D   ++ + VD+R +       E V+ EE G    
Sbjct: 125 PYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHE 184

Query: 358 KDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQ 417
             +    D  G N + EEEG  E  +  E+VEE  +  E+           +EE  EE +
Sbjct: 185 TGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEE 244

Query: 418 QVNNELQLVLDKERKSQG 435
           +   E +   ++++K +G
Sbjct: 245 EEEEEYEQD-ERDQKEEG 261



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 53/241 (21%), Positives = 89/241 (36%), Gaps = 57/241 (23%)

Query: 209 AVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDN 268
           +  R+ +K  P      +K+ +R+   ++ +  P   GS +     + R S+S+  S   
Sbjct: 120 SASREPYKNQP------EKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSS--- 170

Query: 269 SSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQ 328
                      KE+VNSE+                   SD     +G+   +        
Sbjct: 171 -----------KEEVNSEEY-----------------GSDHETGSSGSSDEQGNNT---- 198

Query: 329 EDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQV 388
           E+E+  VE  V+       ++EE  E A +D E  ED     G+ EEE   E  +  E+ 
Sbjct: 199 ENEEEGVEEDVE-------EDEEVEEDAEEDEEVDED-----GEEEEEEEEEEEEEEEEE 246

Query: 389 EEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQ 448
           EE  +  E+  +      G D +   E     +E     D   +S     G DE   + +
Sbjct: 247 EEEYEQDERDQK----EEGNDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERK 302

Query: 449 R 449
           R
Sbjct: 303 R 303


>gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]
          Length = 727

 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 49/198 (24%), Positives = 82/198 (41%), Gaps = 21/198 (10%)

Query: 258 HSKSTVGSSDNSSPQPLKR----KGK-------KEDVNSEKLTKLK--QNVKLKNSQETI 304
           HS+  V    +SS    KR    KGK       +E   SE+  +L   + ++L +S    
Sbjct: 65  HSRQLVSKPLSSSVSNNKRIVSTKGKSATEYKNEEYQRSERNKRLDADRKIRLSSSASRE 124

Query: 305 PNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPA-------EIVDEEEDGEKAN 357
           P  ++       +R   R A     D   ++ + VD+R +       E V+ EE G    
Sbjct: 125 PYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHE 184

Query: 358 KDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQ 417
             +    D  G N + EEEG  E  +  E+VEE  +  E+           +EE  EE +
Sbjct: 185 TGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEE 244

Query: 418 QVNNELQLVLDKERKSQG 435
           +   E +   ++++K +G
Sbjct: 245 EEEEEYEQD-ERDQKEEG 261



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 53/241 (21%), Positives = 89/241 (36%), Gaps = 57/241 (23%)

Query: 209 AVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDN 268
           +  R+ +K  P      +K+ +R+   ++ +  P   GS +     + R S+S+  S   
Sbjct: 120 SASREPYKNQP------EKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSS--- 170

Query: 269 SSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQ 328
                      KE+VNSE+                   SD     +G+   +        
Sbjct: 171 -----------KEEVNSEEY-----------------GSDHETGSSGSSDEQGNNT---- 198

Query: 329 EDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQV 388
           E+E+  VE  V+       ++EE  E A +D E  ED     G+ EEE   E  +  E+ 
Sbjct: 199 ENEEEGVEEDVE-------EDEEVEEDAEEDEEVDED-----GEEEEEEEEEEEEEEEEE 246

Query: 389 EEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQ 448
           EE  +  E+  +      G D +   E     +E     D   +S     G DE   + +
Sbjct: 247 EEEYEQDERDQK----EEGNDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERK 302

Query: 449 R 449
           R
Sbjct: 303 R 303


>gi|222537747 hypothetical protein LOC342979 [Homo sapiens]
          Length = 673

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 51/233 (21%), Positives = 97/233 (41%), Gaps = 24/233 (10%)

Query: 253 SGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIF 312
           +G +R  +S +G+      +  K  G +E   +EK  K ++++ + + ++     DE   
Sbjct: 367 AGRERGDESPLGA------EGAKTGGGEETWEAEK-RKAEESMGIGSEEKPGTGRDEAEM 419

Query: 313 KAGAERS--------ETRGAAEVQEDEDTQVEVP--VDQRPAEIVDEEEDGEKANKDAEQ 362
               ER         E+RG+AE    E    E P  ++++    +  E++G++  + AE+
Sbjct: 420 SPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEE 479

Query: 363 KEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNE 422
           +E    +   +E++GG E  +A ++  E      ++   A   GG +    E+ Q    +
Sbjct: 480 EEVEEPLG--VEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGD 537

Query: 423 LQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDYAAV 475
           L L       S+      +EA      PP      T PE+     Q K   A+
Sbjct: 538 LNLEQGSREGSESQAEEMNEAG-----PPLEANTETRPEKEGPQPQEKPVGAL 585


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 41/231 (17%), Positives = 95/231 (41%), Gaps = 13/231 (5%)

Query: 254 GNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKL-KQNVKLKNSQETIPNSDEGIF 312
           G     +  +G  +    +  ++  K+E+   E+  ++ KQ  ++   +E +   +E + 
Sbjct: 192 GQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQ 251

Query: 313 KAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGD 372
           K   +  +       QE++  + E  + ++  +   EE+ GE+  +  EQ+E        
Sbjct: 252 KQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQ 311

Query: 373 L----------EEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNE 422
           +          EE+ G++     EQ E++ +  EQ  +     G  +E+  ++ +QV  +
Sbjct: 312 MREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQ 371

Query: 423 LQLVLDKER--KSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKD 471
            + +  +E   + Q     + E  +  Q+    E K    E+ E   + K+
Sbjct: 372 EEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKE 422



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/182 (18%), Positives = 81/182 (44%), Gaps = 6/182 (3%)

Query: 292 KQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEE 351
           +Q  +++  +  +   +  + +   +  E  G    QE +  + E  + ++  ++ ++EE
Sbjct: 147 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEE 206

Query: 352 D-GEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQ-QARPARVNGGTD 409
             GE+  +  +Q+E      G+ EE+  ++     EQ E++    EQ Q +  ++    +
Sbjct: 207 QMGEQEEQMQKQEEQM----GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEE 262

Query: 410 EENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQN 469
           +   +E Q    E Q++  KE+  Q   +G+ E  +  Q     E +    E+ E  ++ 
Sbjct: 263 QMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQ 322

Query: 470 KD 471
           ++
Sbjct: 323 EE 324



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 37/218 (16%), Positives = 95/218 (43%), Gaps = 8/218 (3%)

Query: 254 GNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKL-KQNVKLKNSQETIPNSDEGIF 312
           G  R  +  V   +    +   + G++E+   E+  ++ KQ  ++   +E +   +E + 
Sbjct: 178 GQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMG 237

Query: 313 KAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGD 372
           +   +  +     + QE++  + E  + ++  ++ ++EE   K  +  EQ E+     G+
Sbjct: 238 EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQ-EE---QTGE 293

Query: 373 LEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERK 432
            EE+   +     EQ E++ +  EQ        G  +E+  E+ +Q+  + + +  +E +
Sbjct: 294 QEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQ 353

Query: 433 SQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNK 470
               G  +++     ++  + E ++   EE    Q+ +
Sbjct: 354 ---MGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQ 388



 Score = 35.8 bits (81), Expect = 0.087
 Identities = 25/156 (16%), Positives = 66/156 (42%), Gaps = 3/156 (1%)

Query: 260 KSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERS 319
           K      + +  Q  + + ++E +  ++    +Q  +++  +E +   +E +++   +  
Sbjct: 282 KEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMW 341

Query: 320 ETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGR 379
           E +     QE++  + E  + ++  ++  +EE   K  +   ++E+        EE+ G 
Sbjct: 342 EQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEE---QMRKQEEQMGE 398

Query: 380 EATDAPEQVEEILDHSEQQARPARVNGGTDEENGEE 415
           +     EQ E++ +  EQ           +E  GE+
Sbjct: 399 QKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQ 434



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 31/152 (20%), Positives = 68/152 (44%), Gaps = 10/152 (6%)

Query: 275 KRKGKKEDVNSEKLTKLK-QNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDT 333
           K + ++E+   E+  +++ Q  +++  +E +   +E +     E+ E  G  E Q  E  
Sbjct: 282 KEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQM----REQEEQMGKQEEQMWE-- 335

Query: 334 QVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDL---EEEGGREATDAPEQVEE 390
           Q E   +Q+      EE+ GE+  +  +Q+E        +   EE+  ++     +Q E+
Sbjct: 336 QKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQ 395

Query: 391 ILDHSEQQARPARVNGGTDEENGEELQQVNNE 422
           + +  EQ           +E+ GE+ +Q+  +
Sbjct: 396 MGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQ 427



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 28/194 (14%), Positives = 80/194 (41%), Gaps = 15/194 (7%)

Query: 292 KQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEE- 350
           +Q  +++  +  +   +  + +   +  E  G    QE +  + E  V ++  ++ ++E 
Sbjct: 77  EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 136

Query: 351 EDGEKANKDAEQKEDFSGMNGDLEEEGGR----------EATDAPEQVEEILDHSEQQAR 400
           +  E+  +  EQ+       G + E+ G+          +     EQ  ++ +   Q   
Sbjct: 137 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGE 196

Query: 401 PARVNGGTDEENGEELQQVNNELQLVLDKE----RKSQGAGSGQDEADVDPQRPPRPEVK 456
                G  +E+ GE+ +Q+  + + + ++E    ++ +  G  +++     ++  + E +
Sbjct: 197 QEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQ 256

Query: 457 ITSPEENENNQQNK 470
           +   EE    Q+ +
Sbjct: 257 MRKQEEQMREQEEQ 270


>gi|155030232 proline, glutamic acid and leucine rich protein 1
           [Homo sapiens]
          Length = 1130

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 37/122 (30%), Positives = 58/122 (47%), Gaps = 12/122 (9%)

Query: 330 DEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVE 389
           +ED  V + ++    E  +EEE+ E+  ++ E++EDF     D EEE   E  +  E+ E
Sbjct: 875 EEDLTV-ININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEED-EEEYFEEEEEEEEEFE 932

Query: 390 EILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQR 449
           E  +  E         G  +EE  EE ++   EL+ V D E  + G G  ++ A   P  
Sbjct: 933 EEFEEEE---------GELEEEEEEEDEEEEEELEEVEDLEFGTAG-GEVEEGAPPPPTL 982

Query: 450 PP 451
           PP
Sbjct: 983 PP 984



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 22/73 (30%), Positives = 41/73 (56%), Gaps = 5/73 (6%)

Query: 326 EVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKED-----FSGMNGDLEEEGGRE 380
           E +E+E+ + E   ++   +  +EEED E+  ++ E++E+     F    G+LEEE   E
Sbjct: 890 EEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEE 949

Query: 381 ATDAPEQVEEILD 393
             +  E++EE+ D
Sbjct: 950 DEEEEEELEEVED 962



 Score = 37.4 bits (85), Expect = 0.030
 Identities = 43/183 (23%), Positives = 74/183 (40%), Gaps = 15/183 (8%)

Query: 283  VNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQR 342
            +N     + ++  + +  +E     +E  F+   E  E     E +E+E+ + E   ++ 
Sbjct: 881  ININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEG 940

Query: 343  PAEIVDEEEDGEKANKDAEQKEDFS-GMNGDLEEEGGREATDAPEQVEEILDHSEQQARP 401
              E  +EEED E+  ++ E+ ED   G  G   EEG       P  +       + Q  P
Sbjct: 941  ELEEEEEEED-EEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEP 999

Query: 402  ARVNG--------GTDEENGEE----LQQVNNELQLVLDKERKSQGAG-SGQDEADVDPQ 448
                G        GT+EE G +    L       Q  +++E +S  AG   Q+  + +P 
Sbjct: 1000 EPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPS 1059

Query: 449  RPP 451
             PP
Sbjct: 1060 APP 1062


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 49/202 (24%), Positives = 86/202 (42%), Gaps = 31/202 (15%)

Query: 253 SGNDRHSKS-TVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKL-------------- 297
           SGN+    S  + +      +  +R+ KK D    KL KLK+  +L              
Sbjct: 214 SGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQ 273

Query: 298 -KNSQETIPNS---DEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDG 353
            K  +ET+ +    D G+  A  E++ET  AAE   + D + +   D++  +   E+E+ 
Sbjct: 274 RKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKK---DKKKKK--GEKEEK 328

Query: 354 EKANKDAEQKEDFSGMN---GDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDE 410
           EK  K    K     M      L+EE  R+  +  E+++ + +   ++    R+    ++
Sbjct: 329 EKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERL----EQ 384

Query: 411 ENGEELQQVNNELQLVLDKERK 432
           E  E  +Q   E +  L KE K
Sbjct: 385 EKRERKKQKEKERKERLKKEGK 406



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 45/201 (22%), Positives = 87/201 (43%), Gaps = 22/201 (10%)

Query: 275 KRKGKKEDVNSEKLTKLKQNVKLKNSQE---TIPNSDEGIFKAGAERSETRGAAEVQEDE 331
           K++   ED   +K+ +  ++ ++  S E    +   ++G+     E+ ET    E +E+E
Sbjct: 441 KKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGV----PEKEETPPPVEPEEEE 496

Query: 332 DTQVEVPVDQRPAEIVDEEEDGEKANK-DAEQKEDFSGMNGDLEEEGGREATDAPEQVEE 390
           DT+ +  +D   A   DEE +  + NK   E KE     N + EEE         E+ EE
Sbjct: 497 DTE-DAGLDDWEAMASDEETEKVEGNKVHIEVKE-----NPEEEEE--------EEEEEE 542

Query: 391 ILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRP 450
             + SE++      + G++ +  +E      +    LDK+   + +   + ++D D  + 
Sbjct: 543 EDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKE 602

Query: 451 PRPEVKITSPEENENNQQNKD 471
            R   K     E    + +K+
Sbjct: 603 ERAYDKAKRRIEKRRLEHSKN 623



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 34/130 (26%), Positives = 61/130 (46%), Gaps = 14/130 (10%)

Query: 271 PQPLKRKGKKEDVN-SEKLTKLKQNV--KLKNSQETIPNSDEGIFKAGAERSETRGAAEV 327
           PQ L+ K   E +     +  ++Q V  K +      P  +E    AG +  E   + E 
Sbjct: 455 PQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEE 514

Query: 328 QED-EDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPE 386
            E  E  +V + V + P E  +EEE+ E+ ++++E++E         EEEG  E ++  E
Sbjct: 515 TEKVEGNKVHIEVKENPEEE-EEEEEEEEEDEESEEEE---------EEEGESEGSEGDE 564

Query: 387 QVEEILDHSE 396
           + E++ D  +
Sbjct: 565 EDEKVSDEKD 574


>gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homolog
           [Homo sapiens]
          Length = 666

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 51/230 (22%), Positives = 85/230 (36%), Gaps = 22/230 (9%)

Query: 250 SKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDE 309
           S+  G   HS S   S  + +      +   ED +   +         ++S    PN DE
Sbjct: 66  SEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVD--------QHSGSEAPNDDE 117

Query: 310 G---IFKAGAERSETRGAAEV-QEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQK-- 363
                   G+  SE  G+ +   +DE    E   DQ   E +   +D E+A    E K  
Sbjct: 118 DEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQ 177

Query: 364 --EDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNN 421
             +D   M    +EE  + + D  +Q+ E    +    RP         +N +E Q  ++
Sbjct: 178 NSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVA------SDNDDEKQNSDD 231

Query: 422 ELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKD 471
           E Q  L  E K Q +   + +A  +  R    E +     E+     ++D
Sbjct: 232 EEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSED 281



 Score = 37.4 bits (85), Expect = 0.030
 Identities = 56/252 (22%), Positives = 92/252 (36%), Gaps = 46/252 (18%)

Query: 250 SKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDE 309
           S  SG+D HS+     SDN S    +   +  D +             ++S    PN DE
Sbjct: 72  SHHSGSDNHSER----SDNRSEASERSDHEDNDPSDVD----------QHSGSEAPNDDE 117

Query: 310 GI---FKAGAERSETRGAAEVQ-EDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQK-- 363
                   G+  SE  G+ +   +DE    E   DQ   E +   +D E+A    E K  
Sbjct: 118 DEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQ 177

Query: 364 --EDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENG-------- 413
             +D   M    +EE  + + D  +Q+ E    +    RP   +   +++N         
Sbjct: 178 NSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQL 237

Query: 414 ---EELQQVNNELQLVLDKER-----------KSQGAGSGQDEADVDPQRPPRPEVKITS 459
              E++Q  ++E     D+E            KS+ A     E +V   R  R     + 
Sbjct: 238 SDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEV--LRMKRKNAIASD 295

Query: 460 PEENENNQQNKD 471
            E + + +  KD
Sbjct: 296 SEADSDTEVPKD 307



 Score = 36.2 bits (82), Expect = 0.067
 Identities = 34/157 (21%), Positives = 64/157 (40%), Gaps = 10/157 (6%)

Query: 259 SKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAER 318
           S+    +SD+  P       +K++ + E+  +L    K++NS +  P + +   +   + 
Sbjct: 205 SEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDE 264

Query: 319 SETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGG 378
            E    +E     D++ EV   +R   I  + E    A+ D E  +D S   G ++  GG
Sbjct: 265 EEQDHKSESARGSDSEDEVLRMKRKNAIASDSE----ADSDTEVPKDNS---GTMDLFGG 317

Query: 379 REATDAPEQVEEILDHSEQQARPARVNGGTDEENGEE 415
            +   +    E   D      +P   NG   ++  EE
Sbjct: 318 ADDISSGSDGE---DKPPTPGQPVDENGLPQDQQEEE 351


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.129    0.355 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,482,622
Number of Sequences: 37866
Number of extensions: 992561
Number of successful extensions: 6994
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 128
Number of HSP's successfully gapped in prelim test: 521
Number of HSP's that attempted gapping in prelim test: 4642
Number of HSP's gapped (non-prelim): 1633
length of query: 476
length of database: 18,247,518
effective HSP length: 106
effective length of query: 370
effective length of database: 14,233,722
effective search space: 5266477140
effective search space used: 5266477140
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.