Guide to the Human Genome
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Search of human proteins with 239748855

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239748855 PREDICTED: chromosome 6 open reading frame 132
[Homo sapiens]
         (1188 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom...  2455   0.0  
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom...  2455   0.0  
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap...  2455   0.0  
gi|163965366 nascent polypeptide-associated complex alpha subuni...   159   1e-38
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   154   6e-37
gi|116284392 mucin 2 precursor [Homo sapiens]                         148   3e-35
gi|160707881 formin 2 [Homo sapiens]                                  137   5e-32
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...   133   1e-30
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]        124   4e-28
gi|47132519 Ras association and pleckstrin homology domains 1 is...   122   2e-27
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                  119   1e-26
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                  119   1e-26
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                  119   1e-26
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                   119   1e-26
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]    110   1e-23
gi|110349719 titin isoform N2-A [Homo sapiens]                        108   2e-23
gi|150170670 piccolo isoform 2 [Homo sapiens]                         107   7e-23
gi|150378539 piccolo isoform 1 [Homo sapiens]                         107   7e-23
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [...   107   9e-23
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]        105   3e-22
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...   103   1e-21
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...   103   1e-21
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   101   5e-21
gi|110832843 TBP-associated factor 4 [Homo sapiens]                   101   5e-21
gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]        100   6e-21
gi|221139926 NHS-like 1 [Homo sapiens]                                 96   3e-19
gi|55750053 atrophin-1 [Homo sapiens]                                  96   3e-19
gi|55750041 atrophin-1 [Homo sapiens]                                  96   3e-19
gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]               95   3e-19
gi|153792074 proline rich 12 [Homo sapiens]                            95   3e-19

>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
            sapiens]
          Length = 1188

 Score = 2455 bits (6362), Expect = 0.0
 Identities = 1188/1188 (100%), Positives = 1188/1188 (100%)

Query: 1    MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT 60
            MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT
Sbjct: 1    MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT 60

Query: 61   VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR 120
            VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR
Sbjct: 61   VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR 120

Query: 121  LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180
            LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP
Sbjct: 121  LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180

Query: 181  PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240
            PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA
Sbjct: 181  PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240

Query: 241  SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300
            SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR
Sbjct: 241  SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300

Query: 301  SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360
            SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP
Sbjct: 301  SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360

Query: 361  DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA 420
            DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA
Sbjct: 361  DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA 420

Query: 421  QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480
            QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG
Sbjct: 421  QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480

Query: 481  SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540
            SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET
Sbjct: 481  SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540

Query: 541  EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI 600
            EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI
Sbjct: 541  EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI 600

Query: 601  CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA 660
            CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA
Sbjct: 601  CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA 660

Query: 661  TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP 720
            TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP
Sbjct: 661  TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP 720

Query: 721  ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780
            ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR
Sbjct: 721  ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780

Query: 781  EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840
            EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA
Sbjct: 781  EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840

Query: 841  LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900
            LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK
Sbjct: 841  LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900

Query: 901  EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960
            EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL
Sbjct: 901  EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960

Query: 961  PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020
            PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL
Sbjct: 961  PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020

Query: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG 1080
            RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG
Sbjct: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG 1080

Query: 1081 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA 1140
            GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA
Sbjct: 1081 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA 1140

Query: 1141 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS 1188
            DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS
Sbjct: 1141 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS 1188


>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
            sapiens]
          Length = 1188

 Score = 2455 bits (6362), Expect = 0.0
 Identities = 1188/1188 (100%), Positives = 1188/1188 (100%)

Query: 1    MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT 60
            MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT
Sbjct: 1    MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT 60

Query: 61   VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR 120
            VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR
Sbjct: 61   VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR 120

Query: 121  LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180
            LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP
Sbjct: 121  LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180

Query: 181  PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240
            PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA
Sbjct: 181  PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240

Query: 241  SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300
            SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR
Sbjct: 241  SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300

Query: 301  SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360
            SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP
Sbjct: 301  SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360

Query: 361  DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA 420
            DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA
Sbjct: 361  DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA 420

Query: 421  QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480
            QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG
Sbjct: 421  QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480

Query: 481  SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540
            SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET
Sbjct: 481  SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540

Query: 541  EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI 600
            EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI
Sbjct: 541  EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI 600

Query: 601  CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA 660
            CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA
Sbjct: 601  CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA 660

Query: 661  TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP 720
            TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP
Sbjct: 661  TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP 720

Query: 721  ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780
            ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR
Sbjct: 721  ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780

Query: 781  EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840
            EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA
Sbjct: 781  EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840

Query: 841  LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900
            LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK
Sbjct: 841  LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900

Query: 901  EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960
            EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL
Sbjct: 901  EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960

Query: 961  PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020
            PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL
Sbjct: 961  PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020

Query: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG 1080
            RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG
Sbjct: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG 1080

Query: 1081 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA 1140
            GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA
Sbjct: 1081 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA 1140

Query: 1141 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS 1188
            DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS
Sbjct: 1141 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS 1188


>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sapiens]
          Length = 1188

 Score = 2455 bits (6362), Expect = 0.0
 Identities = 1188/1188 (100%), Positives = 1188/1188 (100%)

Query: 1    MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT 60
            MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT
Sbjct: 1    MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT 60

Query: 61   VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR 120
            VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR
Sbjct: 61   VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR 120

Query: 121  LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180
            LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP
Sbjct: 121  LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180

Query: 181  PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240
            PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA
Sbjct: 181  PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240

Query: 241  SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300
            SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR
Sbjct: 241  SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300

Query: 301  SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360
            SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP
Sbjct: 301  SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360

Query: 361  DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA 420
            DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA
Sbjct: 361  DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA 420

Query: 421  QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480
            QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG
Sbjct: 421  QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480

Query: 481  SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540
            SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET
Sbjct: 481  SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540

Query: 541  EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI 600
            EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI
Sbjct: 541  EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI 600

Query: 601  CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA 660
            CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA
Sbjct: 601  CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA 660

Query: 661  TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP 720
            TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP
Sbjct: 661  TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP 720

Query: 721  ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780
            ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR
Sbjct: 721  ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780

Query: 781  EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840
            EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA
Sbjct: 781  EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840

Query: 841  LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900
            LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK
Sbjct: 841  LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900

Query: 901  EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960
            EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL
Sbjct: 901  EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960

Query: 961  PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020
            PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL
Sbjct: 961  PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020

Query: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG 1080
            RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG
Sbjct: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG 1080

Query: 1081 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA 1140
            GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA
Sbjct: 1081 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA 1140

Query: 1141 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS 1188
            DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS
Sbjct: 1141 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS 1188


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  159 bits (403), Expect = 1e-38
 Identities = 245/906 (27%), Positives = 307/906 (33%), Gaps = 188/906 (20%)

Query: 139  IPPPPPGPA-PGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEAL 197
            +P P  GPA P P Q    P       SP      P P  +   P P  AP PP    A 
Sbjct: 893  LPFPKEGPATPAPKQ---APALSMTSSSPKKARATPAPKGIPASPSPKGAPTPP----AA 945

Query: 198  SPPHTLSSPSIP------TPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFP 251
            +PP     P+ P      TPP   PP+P      P P   P P    P SP        P
Sbjct: 946  TPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSP 1005

Query: 252  PGGVTKWKSDVALNGRQAEATRASPPRSPAE---PKGSALGPNPEPHLTFPRSFKVPPPT 308
             G  T               T  SP  SPA    PKG++  P   P    P     P  T
Sbjct: 1006 KGAPT-----------PPAVTPPSPKGSPAATPFPKGASTPPAATP----PSPKGSPAAT 1050

Query: 309  PVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKA 368
            P+     P   A   P  + G    +    P PP+    P S       P P       A
Sbjct: 1051 PL-PKGAPTTPAATLPSPKGGPATPSLKGAPTPPA--ATPPSPKGGPATPSPKGAPMPPA 1107

Query: 369  TAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP--APPLPPAAPPLPCAQKAAHP 426
              P SP+ G +         TP   PP P      PPP  AP  P A PP P    A  P
Sbjct: 1108 ATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPP 1167

Query: 427  PAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDR 486
            P G   TP ++ P+ K     PSP+   ++                              
Sbjct: 1168 PKGAPTTPAATPPSPKGGLATPSPKGAPTT------------------------------ 1197

Query: 487  FLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSL 546
                   P   P S +G  G   P  +   + PA  TPP  P+  L   S       P+ 
Sbjct: 1198 -------PAATPPSPKG--GLATPSPKGAPTTPAA-TPPS-PKGGLATPSPKGAPTTPAA 1246

Query: 547  TLPS-----VDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRIC 601
            T PS         P+ +PTP        L+  L++   K A       PP P+  GG   
Sbjct: 1247 TPPSPKGGPATPPPKGAPTPPA-ATPPSLKGGLATPPHKGAPNPAVVTPPSPK--GG--- 1300

Query: 602  ENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKAT-LWPA 660
                     S P     PP +T   P  S       G   PP  TP     PK T   PA
Sbjct: 1301 ------PATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPP---SPKGTPTLPA 1351

Query: 661  TPPKATLGPATPLKATSGPTTPLKATS---GPAIASTATTLPTTTSQLMAEKDSGPAGQP 717
            T P +  GP TP  +  GPT P    S   GPA+        T  S         P G P
Sbjct: 1352 TTPSSKGGPTTP-SSKEGPTPPAATPSHKGGPAM--------TPPSPKRGPAIPSPKGDP 1402

Query: 718  EKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSS 777
              PA   +S P +A       E    P++G  +    PP  +P                S
Sbjct: 1403 TSPAVIPLS-PKKAPATPVTREGAATPSKGDLT----PPAVTP---------------VS 1442

Query: 778  LSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPA-KPPASAQPTDELLRHPVTGEVVERG 836
            L +  A   P   +GG A P      K  P LPA  PP+  +P       P   +V    
Sbjct: 1443 LKKAPATSAP---KGGPATPSS----KGDPTLPAVTPPSPKEP-------PAPKQVATSS 1488

Query: 837  SPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEAS----SDSIFHSQGTPNSF 892
            SP           +K  +  A +G  +LP  +     +  A+     D I  +    +  
Sbjct: 1489 SP-----------KKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKK 1537

Query: 893  TVVPKLPKEAEKDSPLTTEIPNKWGPRL--GRDAEGTELSRRHNWTKPEPQAPVAWERVA 950
            T     PKEA     +T   P K  P +   ++A  T  S+       E  +P A   V 
Sbjct: 1538 TPATLAPKEALIPPAMTVPSPKK-TPAIPTPKEAPATPSSK-------EASSPPA---VT 1586

Query: 951  PSNLPQGHPLPKSFSSPP---SPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLG 1007
            PS   +G P PK    PP   SPS K    E      V PP PE    P  PAP     G
Sbjct: 1587 PSTY-KGAPSPKELLIPPAVTSPSPK----EAPTPPAVTPPSPE--KGPATPAPK----G 1635

Query: 1008 RQSSPP 1013
              +SPP
Sbjct: 1636 TPTSPP 1641



 Score =  133 bits (334), Expect = 1e-30
 Identities = 201/794 (25%), Positives = 284/794 (35%), Gaps = 185/794 (23%)

Query: 60   TVSESGTATLKARPRVRP---LLTFLPLNAQENHGLAVPTP-----SVPDDFADKEVTGT 111
            T S  G  T  A     P   L T  P  A        P+P     + P   A      T
Sbjct: 1211 TPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAAT 1270

Query: 112  SSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPP--GPAPGPPQDISEPPGGSPLPSPPST 169
               + G L      G   P       ++ PP P  GPA  PP+    PP  +P PSP  +
Sbjct: 1271 PPSLKGGLATPPHKGAPNPA------VVTPPSPKGGPATSPPKGAPTPPAATP-PSPKGS 1323

Query: 170  APPPPPLLLEPPPPPSMAPPPP---PVLEALSP-----PHTLSSPSIPTPPDFIPPAPPL 221
               PPP     P PP++ PP P   P L A +P     P T SS   PTPP   P     
Sbjct: 1324 PGTPPP--KGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGG 1381

Query: 222  AFLAPPPP------PVPAPAPPAPA--------SPHTVGTRLFPPGGVTKWKSDVALNGR 267
              + PP P      P P   P +PA        +P T  TR    G  T  K D+     
Sbjct: 1382 PAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTR---EGAATPSKGDLTPPAV 1438

Query: 268  QAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKE 327
               + + +P  S   PKG    P+ +   T P    V PP+P           +E P  +
Sbjct: 1439 TPVSLKKAPATS--APKGGPATPSSKGDPTLP---AVTPPSP-----------KEPPAPK 1482

Query: 328  EGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPA--SPRLGQSQSQADE 385
            + AT  +P + P  P+    P        A  P  P E+ AT  +   P    +   + +
Sbjct: 1483 QVATSSSPKKAPATPAPMGAPTLP-----AVIPSSPKEVPATPSSRRDPIAPTATLLSKK 1537

Query: 386  RAGTPPPAPPLPPPAPPLP----PPAPPLPPAAPPLPCAQKAAHPPAGFTKT-------- 433
               T  P   L PPA  +P     PA P P  AP  P +++A+ PPA    T        
Sbjct: 1538 TPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPK 1597

Query: 434  -----PKSSSPALKPKPNP--------------PSPENTASSAPVDWRDPSQMEKLRNEL 474
                 P  +SP+ K  P P              P+P+ T +S PV    PS ++      
Sbjct: 1598 ELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPV---TPSSLKDSPTSP 1654

Query: 475  AAYLCGSRREDRFLSHRPGPTVAPQSKEG---KKGPRLPEKETLLSLPAKDTPPGVPEKS 531
            A+  C           + G TV PQ+ +G   KKGP    KE L++ PA ++ P +   +
Sbjct: 1655 ASVTC-----------KMGATV-PQASKGLPAKKGP-TALKEVLVA-PAPESTPIITAPT 1700

Query: 532  LGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPP 591
              G    ++ A            P   P PS               A+  +K  + ++ P
Sbjct: 1701 RKGPQTKKSSATS----------PPICPDPS---------------AKNGSKGPLSTVAP 1735

Query: 592  KPRLEGGRICENGA-DDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGP----------- 639
             P L   +     A   D    P     PP+S    P T+   + +L             
Sbjct: 1736 APLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPS 1795

Query: 640  ---AIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSG----PTTPLKATSGPA-I 691
               ++P   +P P +PPK    P++P      P+ PL         P  P +  SG    
Sbjct: 1796 PPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPF 1855

Query: 692  ASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPS------------E 739
             S    +PT  S          AG P    S +       +G G+ S            +
Sbjct: 1856 QSVLVNMPTPKS----------AGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQD 1905

Query: 740  ATRLPTQGARSSAA 753
            +T+  TQ A+ +AA
Sbjct: 1906 STQATTQQAQLAAA 1919



 Score =  130 bits (328), Expect = 6e-30
 Identities = 192/723 (26%), Positives = 250/723 (34%), Gaps = 119/723 (16%)

Query: 138  LIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPP---PVL 194
            L  PPP G    P      P GG   PSP     P  P    P P   +A P P   P  
Sbjct: 1163 LATPPPKGAPTTPAATPPSPKGGLATPSPKGA--PTTPAATPPSPKGGLATPSPKGAPTT 1220

Query: 195  EALSPPHT---LSSPS---IPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTR 248
             A +PP     L++PS    PT P   PP+P        PPP  AP PPA   P   G  
Sbjct: 1221 PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGG--PATPPPKGAPTPPAATPPSLKGGL 1278

Query: 249  LFPP-GGVTKWKSDVALNGRQAEATRASPPR--------SPAEPKGSALGPNPEPHLTFP 299
              PP  G          + +   AT  SPP+        +P  PKGS   P P+   T P
Sbjct: 1279 ATPPHKGAPNPAVVTPPSPKGGPAT--SPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPP 1336

Query: 300  RSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPE 359
                V PP+P  T ++P       P  + G T  +    P PP              A  
Sbjct: 1337 ---AVTPPSPKGTPTLPA----TTPSSKGGPTTPSSKEGPTPP--------------AAT 1375

Query: 360  PDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPC 419
            P   G   A  P SP+ G              PA P P   P  P   P  P  AP  P 
Sbjct: 1376 PSHKGG-PAMTPPSPKRG--------------PAIPSPKGDPTSPAVIPLSPKKAPATPV 1420

Query: 420  AQKAAHPPAGFTKTPKSSSP-ALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYL 478
             ++ A  P+    TP + +P +LK  P   +P+    + P    DP+        L A  
Sbjct: 1421 TREGAATPSKGDLTPPAVTPVSLKKAPATSAPKG-GPATPSSKGDPT--------LPAVT 1471

Query: 479  CGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPA------KDTP--PGVPEK 530
              S +E       P P     S   KK P  P      +LPA      K+ P  P     
Sbjct: 1472 PPSPKEP------PAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRD 1525

Query: 531  SLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLP 590
             +  ++   ++  P+   P    IP     PS ++        + +  E  A PS     
Sbjct: 1526 PIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKK-----TPAIPTPKEAPATPSSKEAS 1580

Query: 591  PKPRLEGGRICENGADDDK-LSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIP-PKATP- 647
              P +        GA   K L  P A   P       P     P    GPA P PK TP 
Sbjct: 1581 SPPAVTPSTY--KGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPT 1638

Query: 648  -EPAIPPKATLWPATPPKAT--LGPATP-----LKATSGPTTPLKATSGPAIASTATTLP 699
              P  P      P +P   T  +G   P     L A  GPT   +    PA        P
Sbjct: 1639 SPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPA--------P 1690

Query: 700  TTTSQLMAEKDSGPAGQPEKPASQEV-STPSQARGEGSP----SEATRLPTQ--GARSSA 752
             +T  + A    GP  +     S  +   PS   G   P    + A  LP Q   ++++ 
Sbjct: 1691 ESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAK 1750

Query: 753  AFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVK-EPPGLPA 811
                  SP G   P   K     ++ + E  +  P  A   AA P  PV +   P  +P 
Sbjct: 1751 GKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAA-PSPPVSLPLAPSPVPT 1809

Query: 812  KPP 814
             PP
Sbjct: 1810 LPP 1812



 Score =  120 bits (302), Expect = 6e-27
 Identities = 186/735 (25%), Positives = 253/735 (34%), Gaps = 116/735 (15%)

Query: 138  LIPPPPPGPAPGPPQDISEPPGGSPLPSP---PST--APPPPPLLLEPPPPPSMAPPP-- 190
            L  P P G    P      P GG   PSP   P+T  A PP P      PPP  AP P  
Sbjct: 1209 LATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPA 1268

Query: 191  --PPVLEA--LSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPH-TV 245
              PP L+    +PPH       P P    PP+P       PP   P P    P SP  + 
Sbjct: 1269 ATPPSLKGGLATPPH----KGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSP 1324

Query: 246  GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVP 305
            GT   PP G     +    + +      A+ P S   P   +    P P    P     P
Sbjct: 1325 GTP--PPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGP 1382

Query: 306  ---PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDC 362
               PP+P R  +IP   + +           +P + P  P      A+    D  P    
Sbjct: 1383 AMTPPSPKRGPAIP---SPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVT 1439

Query: 363  PGEL-KATAPASPRLGQSQSQADERAGTPPPAPPLP--PPAP--------PLPPPAPPLP 411
            P  L KA A ++P+ G +   +      P   PP P  PPAP        P   PA P P
Sbjct: 1440 PVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAP 1499

Query: 412  PAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLR 471
              AP LP    ++  P     TP S    + P     S +  A+ AP +   P  M    
Sbjct: 1500 MGAPTLPAVIPSS--PKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTV-- 1555

Query: 472  NELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKS 531
                                P P   P     K+ P  P      S  A   P   P   
Sbjct: 1556 --------------------PSPKKTPAIPTPKEAPATPS-----SKEASSPPAVTPSTY 1590

Query: 532  LGGSSLTETEAAPSLTLPSVDYIPQDSPT-PSVRQIRNELEARLSSAAEKEAKPSI--GS 588
             G  S  E    P++T PS    P+++PT P+V     E      +       P +   S
Sbjct: 1591 KGAPSPKELLIPPAVTSPS----PKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSS 1646

Query: 589  LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648
            L   P       C+ GA   + SK +     P        T+L+ + ++ PA  P++TP 
Sbjct: 1647 LKDSPTSPASVTCKMGATVPQASKGLPAKKGP--------TALK-EVLVAPA--PESTPI 1695

Query: 649  PAIP----PKATLWPATPPKATLGPATPLKATSGPTTPLKATS-GPAIASTATTLPTTTS 703
               P    P+     AT P     P+    A +G   PL   +  P +     +  T   
Sbjct: 1696 ITAPTRKGPQTKKSSATSPPICPDPS----AKNGSKGPLSTVAPAPLLPVQKDSSKTAKG 1751

Query: 704  QLMAEKDSGPAGQPEKPASQEVST---------PSQARGEGSPSEATRLPTQGARSSAAF 754
            +  +    GP   PE  AS  ++          P  A    +PS    LP          
Sbjct: 1752 KDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPL-APSPVPTL 1810

Query: 755  PPK-----TSPG-GGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEP-- 806
            PPK     +SPG   E P        +  L   + ++ P    GG   P + V V  P  
Sbjct: 1811 PPKQQFLPSSPGLVLESPSKPLAPADEDEL---LPLIPPEPISGGV--PFQSVLVNMPTP 1865

Query: 807  --PGLPAKPPASAQP 819
               G+P   P++ QP
Sbjct: 1866 KSAGIPVPTPSAKQP 1880



 Score =  107 bits (266), Expect = 9e-23
 Identities = 260/1056 (24%), Positives = 349/1056 (33%), Gaps = 190/1056 (17%)

Query: 165  SPPSTAPPPPPLLLEPPPPPSMAP--PPPPVLEALSPPHTLSSPSIPTPPDF--IPPAPP 220
            SPP ++ P   +    P    MAP  P  P  +  +      SP +P P D   +P +  
Sbjct: 464  SPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVL 523

Query: 221  LAFLAPPP-PPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASP--P 277
            + F        VPA    AP SP   G        V         N    ++T +SP  P
Sbjct: 524  VKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIP 583

Query: 278  RSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSR 337
             SP           P P         +  P    TS + V  +    + +  A   +   
Sbjct: 584  LSPEATLAKKSLGEPLP---------IGKPASSMTSPLGVNSSASVIKTDSYAGPDSAG- 633

Query: 338  LPLPPSFHIRPASQVYPDRAPEP------DCPGELKATAPASPRLGQSQSQADE----RA 387
             PL  S  I P    +P  + +P         G    T  ASP L  + S A +    + 
Sbjct: 634  -PLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKE 692

Query: 388  GTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKS-SSPALKPKPN 446
            GT    P L P A    P AP     +P   CA  A    A   + PKS  SP+L P   
Sbjct: 693  GTLTTLP-LVPTASENCPVAP-----SPQNTCAPLATLVLA--PEIPKSVPSPSLPPAGT 744

Query: 447  PPSPE------NTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGP------ 494
            PP  +      +T++ APV    P +     +  A+    S+    +L+  P P      
Sbjct: 745  PPGTKKVDGISHTSALAPVA-SSPKECPT-EDSGASATASSKGTLTYLADSPSPLGVSVS 802

Query: 495  --TVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG-VPEKSLGGSSLTETEAAPSLTLPSV 551
              T  P +K+G  GP  P     LS P        +PE SL   S   ++ +P+ T    
Sbjct: 803  PQTKRPPTKKGSAGPDTPIGN--LSSPVSPVEASFLPENSL---SFQGSKDSPATTHSPT 857

Query: 552  DYIPQDSPTPSVRQIRNELEARLSSAAEKEAK-PSIGSLP-PKPRLEGGRICENGADDDK 609
               P+ +PTPS       L  +  +   KE   PS+ +LP PK   EG            
Sbjct: 858  PPSPKGAPTPSAV---TPLSPKGVTLPPKETPTPSVVNLPFPK---EGP----------- 900

Query: 610  LSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA-TPPKATLG 668
                 A   P Q+  L  T+S   KA   PA  PK  P    P  A   PA TPP    G
Sbjct: 901  -----ATPAPKQAPALSMTSSSPKKARATPA--PKGIPASPSPKGAPTPPAATPPSPKGG 953

Query: 669  PATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTP 728
            PATP  +     TP  AT        AT  P       A     P G P  P+ +   TP
Sbjct: 954  PATP--SPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTP 1011

Query: 729  ---SQARGEGSPSEATRLPTQGARSSAAFPP--KTSPGGGEVPCLYKPHCHQSSLSREVA 783
               +    +GSP+ AT  P   +   AA PP  K SP    +P                A
Sbjct: 1012 PAVTPPSPKGSPA-ATPFPKGASTPPAATPPSPKGSPAATPLP---------KGAPTTPA 1061

Query: 784  VVMPTLARGGAAGP---GEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840
              +P+  +GG A P   G P      P  P   PA+  P               +G+PM 
Sbjct: 1062 ATLPS-PKGGPATPSLKGAPTPPAATPPSPKGGPATPSP---------------KGAPMP 1105

Query: 841  LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900
               A     + G +     G  + P +         A+       +G P +    P  PK
Sbjct: 1106 PA-ATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPP----KGAPTTPAATPPSPK 1160

Query: 901  EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960
                   L T  P K  P        T  S +     P P+        AP+      P 
Sbjct: 1161 GG-----LATP-PPKGAPTT---PAATPPSPKGGLATPSPKG-------APTTPAATPPS 1204

Query: 961  PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020
            PK   + PSP                PP P+       P+P        ++PP       
Sbjct: 1205 PKGGLATPSPKGAPTTPA------ATPPSPK--GGLATPSPKGAPTTPAATPPS------ 1250

Query: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRG------ 1074
               P  GP  PP  G    PA    +  GGL                   PH+G      
Sbjct: 1251 ---PKGGPATPPPKGAPTPPAATPPSLKGGL----------------ATPPHKGAPNPAV 1291

Query: 1075 --PGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEA 1132
              P  P GG   + S P      P         S G  PP G   P      + +G    
Sbjct: 1292 VTPPSPKGGP--ATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTL 1349

Query: 1133 KHKAPGSADYGFAPAAGRSP----YTTTRYGSPINT 1164
                P S      P++   P     T +  G P  T
Sbjct: 1350 PATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMT 1385



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 229/1014 (22%), Positives = 332/1014 (32%), Gaps = 177/1014 (17%)

Query: 192  PVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPV-PAPAPPAPASPHTVGTRLF 250
            P ++ +S  H+ +  S P+    IPP P    + P      P  AP     P T+ +   
Sbjct: 334  PTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITC 393

Query: 251  PPGGVTKWKSDVALNGRQAEATRASPPRS-----PAEPKGSALGPNP-----------EP 294
             P G     +  +L+   +   ++SP  +      A+   S++G  P            P
Sbjct: 394  SPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAP 453

Query: 295  HLTFPRSFKVPPP------------TPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP 342
              TF  +  V PP            +P      PV  A + P  +   T + P   PLP 
Sbjct: 454  TTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPV--APKEPSTQVATTLRIPVSPPLPD 511

Query: 343  SFHIR--PASQV--YPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPP 398
               ++  P+S +  +P +      P  L+  AP SP      +QA       P   PL  
Sbjct: 512  PEDLKNLPSSVLVKFPTQKDLQTVPASLEG-APFSP------AQAGLTTKKDPTVLPLVQ 564

Query: 399  PAPPLPPP-----APPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENT 453
             AP   P      + P  P +P    A+K+   P           P  KP  +  SP   
Sbjct: 565  AAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPL----------PIGKPASSMTSPLGV 614

Query: 454  ASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPT-VAPQSKEGKKG---PRL 509
             SSA V   D          L      +     F      P  VAP + +G         
Sbjct: 615  NSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTAS 674

Query: 510  PEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNE 569
            P  E  +SL  K+ P  V E +L    L  T +      PS    PQ++  P    +   
Sbjct: 675  PFLEGTVSLAPKNHP--VKEGTLTTLPLVPTASENCPVAPS----PQNTCAPLATLV--- 725

Query: 570  LEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629
            L   +  +    + P  G+ P   +++G  I    A     S P  K  P + +    T 
Sbjct: 726  LAPEIPKSVPSPSLPPAGTPPGTKKVDG--ISHTSALAPVASSP--KECPTEDSGASATA 781

Query: 630  SLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGP 689
            S +     G       +P P       L  +  P+    P    K ++GP TP+   S P
Sbjct: 782  SSK-----GTLTYLADSPSP-------LGVSVSPQTKRPPTK--KGSAGPDTPIGNLSSP 827

Query: 690  AIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGAR 749
                 A+ LP  +      KDS        PA+    TP   +G  +PS  T L  +G  
Sbjct: 828  VSPVEASFLPENSLSFQGSKDS--------PATTHSPTPPSPKGAPTPSAVTPLSPKG-- 877

Query: 750  SSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGL 809
                 PPK +P    V   +      +   ++   +  T     ++ P +      P G+
Sbjct: 878  --VTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMT-----SSSPKKARATPAPKGI 930

Query: 810  PAKPPASAQPTDELLRHPVTGEVVERGSP--MALLLAARQRAQKGRSVGAALGRSSLPGS 867
            PA P     PT      P         SP       AA   + KG     +   +  P +
Sbjct: 931  PASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPA 990

Query: 868  LRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGT 927
                S +   ++ S    +G P    V P  P    K SP  T  P           +G 
Sbjct: 991  ATPPSPKGGPATPS---PKGAPTPPAVTPPSP----KGSPAATPFP-----------KGA 1032

Query: 928  ELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPS---PSNKREEEEEEFNFE 984
                    T P    P      +P   P   PLPK   + P+   PS K           
Sbjct: 1033 S-------TPPAATPP------SPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGA 1079

Query: 985  VIPP---PPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPA 1041
              PP   PP     P  P+P    +   ++PP          P  G   PP  G    PA
Sbjct: 1080 PTPPAATPPSPKGGPATPSPKGAPMPPAATPPS---------PKGGLATPPHKGAPTTPA 1130

Query: 1042 GARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEM 1101
                +  GGL      G            P   P  P GG    L++P    P  G P  
Sbjct: 1131 ATPPSPKGGLATPPPKGAPT--------TPAATPPSPKGG----LATP----PPKGAPTT 1174

Query: 1102 RRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSADYGFAPAAGRSPYTT 1155
                    +P GGL  P      + +GA       P S   G A  + +   TT
Sbjct: 1175 PAATPP--SPKGGLATP------SPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1220



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 262/1131 (23%), Positives = 369/1131 (32%), Gaps = 144/1131 (12%)

Query: 131  GQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPP 190
            GQ G  L   PPP  PAP     +S     SP PSP + A  P    LE P P S +   
Sbjct: 39   GQPGPTL---PPPCSPAP-QQCPLSAANQASPFPSPSTIASTP----LEVPFPQSSSGTA 90

Query: 191  PPVLEALSPPHTLSSPSIPTPPDFIPPA------PPLAFLAPPPPPVPAPAPPAPASPHT 244
             P+  A   P  L  P++  PP  I PA      P +A      P   AP      +PH+
Sbjct: 91   LPLGTAPEAPTFL--PNLIGPP--ISPAALALASPMIAPTLKGTPSSSAPLALVALAPHS 146

Query: 245  V-GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFK 303
            V  +  FPP  +T   S VA+          S P +P+EPK +    N  P    P    
Sbjct: 147  VQKSSAFPPNLLTSPPS-VAV-AESGSVITLSAPIAPSEPKTNL---NKVPSEVVPNPKG 201

Query: 304  VPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRA-----P 358
             P P P   S++P          + G      S     P+  +  AS    D        
Sbjct: 202  TPSP-PCIVSTVPYHCVTPMASIQSGVA----SLPQTTPTTTLAIASPQVKDTTISSVLI 256

Query: 359  EPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLP 418
             P  PG L    P SP    S S       + P        A P  PP  P+   +   P
Sbjct: 257  SPQNPGSLSLKGPVSPPAALSLS-----TQSLPVVTSSQKTAGPNTPPDFPISLGSHLAP 311

Query: 419  CAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAP----VDWRDPSQMEKLRNEL 474
              Q +        +T  S+      K       +T +S P    V    PS+ E +   +
Sbjct: 312  LHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATV 371

Query: 475  AAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG-------- 526
            AA+   +   D+  S     T +P               T  SL  K +P          
Sbjct: 372  AAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTT--SLILKSSPNATYHYPLVA 429

Query: 527  -VPEKSLGGSSLTETE-----AAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSA--A 578
             +P  S+G + L  T      AAP+ T      +     +  +  I     A L  A  A
Sbjct: 430  QMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVA 489

Query: 579  EKEAKPSIGS---LPPKPRLEGGRICENGADDDKLSKPVAKNLP--PQSTTLLP------ 627
             KE    + +   +P  P L      +N      +  P  K+L   P S    P      
Sbjct: 490  PKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQA 549

Query: 628  --TTSLQPKAMLGPAIPPKATP---EPAIPPKATLWP-ATPPKATLGPATPL-KATSGPT 680
              TT   P  +      PK +P     +  P+  L P AT  K +LG   P+ K  S  T
Sbjct: 550  GLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMT 609

Query: 681  TPLKATSGPAIASTATTL-PTTTSQLMAEKDSGP--AGQPEKPASQEVSTPSQARGEGSP 737
            +PL   S  ++  T +   P +   L+      P  A  P + A      P+ A+G    
Sbjct: 610  SPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKG---T 666

Query: 738  SEATRLPTQGARSSAAFPPKTSP-GGGEVPCL-----YKPHCHQSSLSREVAVVMPTLAR 791
            S  T   +     + +  PK  P   G +  L        +C  +   +     + TL  
Sbjct: 667  STYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATL-- 724

Query: 792  GGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVE--RGSPMALLLAARQRA 849
                 P  P  V  P   PA  P   +  D +        V    +  P     A+   +
Sbjct: 725  --VLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATAS 782

Query: 850  QKGRSVGAA-----LGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK---- 900
             KG     A     LG S  P + R  + +  A  D+   +  +P S      LP+    
Sbjct: 783  SKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLS 842

Query: 901  -EAEKDSPLTTEIPNKWGPR--------LGRDAEGTELSRRHNWTKPEPQAPVAWERVAP 951
             +  KDSP TT  P    P+             +G  L  +   T      P   E  A 
Sbjct: 843  FQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPAT 902

Query: 952  SNLPQGHPLPKSFSSP----PSPSNKREEEEEEFNFEVIPP---PPEFSNDPEPPAPALQ 1004
                Q   L  + SSP     +P+ K             PP   PP     P  P+P   
Sbjct: 903  PAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWA 962

Query: 1005 YLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGR---SL 1061
                 ++PP          P  GP  P   G    PA    +  GG    S  G      
Sbjct: 963  PTPPAATPPS---------PKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPA 1013

Query: 1062 IKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLS 1121
            +      G P   P  P G +    ++P    P P G       +A   P G    P  +
Sbjct: 1014 VTPPSPKGSPAATP-FPKGASTPPAATP----PSPKGSP-----AATPLPKGAPTTPAAT 1063

Query: 1122 LEGAARGAAEAKHKAPGSADYGFAPAAGRSPYTTTRYGSPINTFTVRPGTR 1172
            L     G A    K   +      P+    P T +  G+P+      P  +
Sbjct: 1064 LPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPK 1114



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 204/948 (21%), Positives = 304/948 (32%), Gaps = 201/948 (21%)

Query: 167  PSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAP 226
            P  A    P   +  P P       P+  ALS    L  P  PT P    PAP    L+ 
Sbjct: 2    PGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPG-PTLPPPCSPAPQQCPLSA 60

Query: 227  PPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGS 286
                 P P+P   AS     T L  P   +   + + L G   EA    P         +
Sbjct: 61   ANQASPFPSPSTIAS-----TPLEVPFPQSSSGTALPL-GTAPEAPTFLP---------N 105

Query: 287  ALGPNPEP-HLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFH 345
             +GP   P  L        P      +SS P+     AP   + ++   P+ L  PPS  
Sbjct: 106  LIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVA 165

Query: 346  IRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPP 405
            +  +  V    AP           AP+ P+   ++           P+  +P P      
Sbjct: 166  VAESGSVITLSAP----------IAPSEPKTNLNK----------VPSEVVPNPK---GT 202

Query: 406  PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPS 465
            P+PP   +  P  C    A   +G    P+++        +P   + T SS  +  ++P 
Sbjct: 203  PSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPG 262

Query: 466  QMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPP 525
             +  L+  ++     S      LS +  P V    K    GP  P  +  +SL +   P 
Sbjct: 263  SL-SLKGPVSPPAALS------LSTQSLPVVTSSQKTA--GPNTP-PDFPISLGSHLAP- 311

Query: 526  GVPEKSLGGSSLTETEAAPSLTLP-----SVDYIPQDSPTPSVRQIRNELEAR-----LS 575
             + + S G   L       +L+ P     SVD+    +  PS R +   L +R      +
Sbjct: 312  -LHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPAT 370

Query: 576  SAAEKEAKPSIGSLP---------PKPRLEGGRICENGADDDKLSK---------PVAKN 617
             AA     PS+   P         P   L              + K         P+   
Sbjct: 371  VAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQ 430

Query: 618  LP-------------PQSTTLLPTTSLQPKAMLGPAIP--PKATPEPAIPPKATLWPATP 662
            +P             P +    PTT+ +    + P +   P +  EP  P    + P  P
Sbjct: 431  MPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAP 490

Query: 663  PKATLGPATPLKATSGPTTP----LK-------------------------ATSGPAIAS 693
             + +   AT L+    P  P    LK                         A   PA A 
Sbjct: 491  KEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAG 550

Query: 694  TATTL-PTTTSQLMAEKDSGPAGQ-----PEKPASQEVSTPSQARGE----GSPSEATRL 743
              T   PT    + A   + P+ Q     PE P S E +   ++ GE    G P+ +   
Sbjct: 551  LTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTS 610

Query: 744  PTQGARSSAAFPPKTSPGGGE------VPCLYKPHCHQSSL-SREVAVVMPTLARG---- 792
            P  G  SSA+     S  G +         L  P      L S + A V PT A+G    
Sbjct: 611  PL-GVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTY 669

Query: 793  ------------GAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840
                          A    PV+      LP  P AS          PV        +P+A
Sbjct: 670  TTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASE-------NCPVAPSPQNTCAPLA 722

Query: 841  LLLAARQRAQKGRS-----VGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVV 895
             L+ A +  +   S      G   G   + G     +    ASS     ++ +  S T  
Sbjct: 723  TLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATAS 782

Query: 896  PK--LPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSN 953
             K  L   A+  SPL   +                         P+ + P   +  A  +
Sbjct: 783  SKGTLTYLADSPSPLGVSV------------------------SPQTKRPPTKKGSAGPD 818

Query: 954  LPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAP 1001
             P G     + SSP SP       E   +F+     P  ++ P PP+P
Sbjct: 819  TPIG-----NLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSP 861


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score =  154 bits (388), Expect = 6e-37
 Identities = 229/808 (28%), Positives = 302/808 (37%), Gaps = 156/808 (19%)

Query: 139  IPPPPPGPAPGPPQDISEPPGGSPLP-SPPSTAPPPPPLLLEPPP-------PPSMAPPP 190
            +PPP     P P      PP  +PLP +PPS + PP    L  PP       PPSM  PP
Sbjct: 317  VPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPP 376

Query: 191  ---PPVLEALSP---PHTLSSPSIPTPP-----------------------DFIPPAPPL 221
               PP L+ + P   PH+L+SPS+  PP                        F+  +P  
Sbjct: 377  MQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQ 436

Query: 222  AFLAPPPPPVPAPAPP----------APASPHTVGTRLFPPGGVTKWKSDVALNGRQAEA 271
               +   P  PA  PP           PASP  + T L P   V+   S + ++  QA +
Sbjct: 437  TQASLTSPSRPASTPPDSPPLQAPLSLPASP-PLQTSLSP--AVSPLSSPLTIHPLQALS 493

Query: 272  TRASPPRSPAEPKGSALGPNPE-------PHL-TFPRSFKVPP--------PTPVRTSSI 315
            + AS   SP  P  S + P  E       P L T P S   PP        P P++T+S 
Sbjct: 494  SLAS--HSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASA 551

Query: 316  PVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAP---- 371
            P+      P  E      AP  L  PPS          P   P P+ P  +    P    
Sbjct: 552  PL----TTPHLETPPC-PAPCPLQAPPS----------PLTTPPPETPSSIATPPPQAPP 596

Query: 372  --ASPRLGQSQSQADERAGTPPP-APP---LPP-PAPPLPPPAPPLPPAAPPLPCAQKA- 423
              ASP L    S       TPPP APP   LPP  APP PP +PPL P A P P A  A 
Sbjct: 597  ALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNAL 656

Query: 424  AHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRR 483
            A        +P  S P   P   P SP  + S+ P     PS        LAA       
Sbjct: 657  AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPS--------LAA------- 701

Query: 484  EDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAA 543
                L   P P  +P        P  P+    L+ P    PP  P       S T     
Sbjct: 702  --PPLQVPPSPPASPPMSPSATPP--PQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRV 757

Query: 544  PSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICEN 603
            P L       +P   P+P      + L      A    A P + +LP  P    G+   +
Sbjct: 758  PPLLAAPPLQVP---PSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS 814

Query: 604  GADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPP 663
             +    +S P+A   PPQ+  +L    LQ        +PP     P +  +A   P TP 
Sbjct: 815  PSASLPMS-PLA-TPPPQAPPVLAAPLLQ--------VPPSPPASPTL--QAPRRPPTPG 862

Query: 664  KAT--LGPATPLKATSGP-----TTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAG- 715
              T   GP   L    GP      +P    SGP +A  +++  +T  +L    DSGP G 
Sbjct: 863  PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRG-YDSGPEGG 921

Query: 716  -QPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSS-AAFPPKTSPGGGEVPC-LYKPH 772
                 P   E++    A     P  A  L  +GA  +   +PP T PG  +  C +Y+  
Sbjct: 922  AAASPPPDAELAACHPAAWSRGP--APPLAFRGAPGAPLPWPPATGPGSADGLCTIYETE 979

Query: 773  CHQSSLSREVAV---VMPTLARG-GAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPV 828
              +S+     A+     P  + G  AAG G         G  ++ P  A+   EL    +
Sbjct: 980  GPESATPAPGALDPGPSPGTSGGKAAAGAG--------AGASSRSPKQAR-LGELPLGAL 1030

Query: 829  TGEVVERGSPMALLLAARQRAQKGRSVG 856
               VV+      LLLAA + A  G   G
Sbjct: 1031 QASVVQHLLSRTLLLAAAEGAAGGSGGG 1058



 Score =  124 bits (310), Expect = 7e-28
 Identities = 190/758 (25%), Positives = 266/758 (35%), Gaps = 136/758 (17%)

Query: 158 PGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDF--- 214
           P     P  P+    P P  L+   PP + PP      AL P   LSS  + TP      
Sbjct: 257 PSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP---LSSSPLATPSPSGTK 313

Query: 215 ---IPP----APPLAFLAPPPPPVPAP---APPAPASPHTVGTRLFPPGGVTKWKSDVAL 264
              +PP    A PL    PP PP+  P   APP+P++P ++ T   PP          A 
Sbjct: 314 ARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPP----------AT 363

Query: 265 NGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAP 324
              QA  +  +PP   A P    + P   PH     S +  PP+P+  SS+    +  +P
Sbjct: 364 PPSQAPPSMTTPPMQ-APPSLQTIPPIQVPHSLTSPSLQA-PPSPLALSSLQATTSLGSP 421

Query: 325 RKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQAD 384
             +  AT    +  P      +   S+  P   P    P +   + PASP L  S S A 
Sbjct: 422 TLQ--ATHSFLTMSPRQTQASLTSPSR--PASTPPDSPPLQAPLSLPASPPLQTSLSPAV 477

Query: 385 ERAGTPPPAPPL---------PPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPK 435
               +P    PL          P AP      PPL   +   P + +   PPA  T  P 
Sbjct: 478 SPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQT--PPASLTTPPL 535

Query: 436 SSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPT 495
            + P+L      P P  TAS+       P     L        C        L   P P 
Sbjct: 536 ENLPSL-----APPPLQTASA-------PLTTPHLETPPCPAPCP-------LQAPPSPL 576

Query: 496 VAPQSKEGKKGPRLPEKETLLSLPAKDTPP--------GVPEKSLGGSSLTETEAAPSLT 547
             P           PE  + ++ P    PP        G+P   L   +    +A P L 
Sbjct: 577 TTPP----------PETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLA 626

Query: 548 LPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADD 607
           LP +   P    +P +  +      +  +A       +  S PP P ++           
Sbjct: 627 LPPLQAPPSPPASPPLSPLATP-SPQAPNALAVHLLQAPFSPPPSPPVQA---------- 675

Query: 608 DKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGP-AIPPKATPEPAIPPKATLWPATPPKAT 666
              S P +   PP S +  P +   P     P  +PP     P + P AT  P  PP   
Sbjct: 676 -PFSPPAS---PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA 731

Query: 667 LGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVS 726
              A PL+    P       + P ++ +AT  P     L A     P   P  PAS  +S
Sbjct: 732 ---APPLQVPPSP------PASPPMSPSATPPPRVPPLLAAPPLQVP---PSPPASLPMS 779

Query: 727 TPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVM 786
             ++   +  P+ AT  P Q   S    PP + PG             Q+  S   ++ M
Sbjct: 780 PLAKPPPQAPPALATP-PLQALPS----PPASFPG-------------QAPFSPSASLPM 821

Query: 787 PTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVT--GEVVERGSPMALLLA 844
             LA      P  PV       +P  PPAS  PT +  R P T   +    G  + L LA
Sbjct: 822 SPLATPPPQAP--PVLAAPLLQVPPSPPAS--PTLQAPRRPPTPGPDTSVSGPRLTLALA 877

Query: 845 ARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSI 882
                   RS  + L    L G    HS  A ++ + +
Sbjct: 878 PGPPPPPSRSPSSTLSGPDLAG----HSSSATSTPEEL 911



 Score =  119 bits (298), Expect = 2e-26
 Identities = 277/1177 (23%), Positives = 374/1177 (31%), Gaps = 259/1177 (22%)

Query: 130  PGQYGQDLLIPPPPPGPAPGPP-----------------QDISEPPGGSPLPSPPSTAPP 172
            P      LL P PP  P P PP                 + ++E  GG    + P +AP 
Sbjct: 17   PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76

Query: 173  PPPL----------LLEPP-------PPPSMAPPPPPVLEALSPPHTLSSPSIPTP---- 211
              P              PP        PP+    P PV    S P   S  + P P    
Sbjct: 77   AGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPV----SSPGRASGTTRPGPLGQK 132

Query: 212  --------------PDFIPPAPPLAFLAPPPPPVPAPAPPAPA---SPHTVGTRLFPPGG 254
                              P    L+  A      P P  P+PA        GT +  P  
Sbjct: 133  GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRP 192

Query: 255  VTKWKSDVALNGRQAEATRAS-----PPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTP 309
                +      G +   + AS      P   A  + SA G    P      S   P  +P
Sbjct: 193  APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 252

Query: 310  VRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKAT 369
             R+       A+  PR     ++  P  L       +RP  QV P R       G L ++
Sbjct: 253  ARSG----PSARGTPRAPAHPSQPKPKGLQA-----LRP-PQVTPPRKDAAPALGPLSSS 302

Query: 370  APASPRLGQSQSQ---ADERAGTPPPA--PPLPPPAPPLP--PPAPPLPPAAP--PLPCA 420
              A+P    ++++     + A TP PA  PP PP A PLP  PP+P  PP+    P P A
Sbjct: 303  PLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPA 362

Query: 421  QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480
               +  P   T  P  + P+L+  P    P +  S +      P  +  L+   +     
Sbjct: 363  TPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPT 422

Query: 481  SRREDRFLSHRPGPTVA---PQSKEGKKGPRLPEKETLLSLPAK-----DTPPGV----- 527
             +    FL+  P  T A     S+     P  P  +  LSLPA         P V     
Sbjct: 423  LQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSS 482

Query: 528  -----------------PEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL 570
                             P+  L    +   E   SL  PS+   P    TP +  + +  
Sbjct: 483  PLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLA 542

Query: 571  EARLSSAAEKEAKPSIGSLP-PKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629
               L +A+     P + + P P P       C   A    L+ P     PP++ + + T 
Sbjct: 543  PPPLQTASAPLTTPHLETPPCPAP-------CPLQAPPSPLTTP-----PPETPSSIATP 590

Query: 630  SLQ-PKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSG 688
              Q P A+  P  P +  P P + P AT  P  PP   L    PL+A   P       + 
Sbjct: 591  PPQAPPALASP--PLQGLPSPPLSPLATPPPQAPPXLAL---PPLQAPPSP------PAS 639

Query: 689  PAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGA 748
            P ++  AT  P   + L       P   P  P  Q   +P               P    
Sbjct: 640  PPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSP---------------PASPP 684

Query: 749  RSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPG 808
             S +A PP  +P     P L  P    +S     +   P  A    A P  P++V  PP 
Sbjct: 685  VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP--PLQV--PPS 740

Query: 809  LPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSL---- 864
             PA PP S   T                 P    L A    Q   S  A+L  S L    
Sbjct: 741  PPASPPMSPSATP---------------PPRVPPLLAAPPLQVPPSPPASLPMSPLAKPP 785

Query: 865  ---PGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLG 921
               P +L     QA  S  + F  Q         P  P  +   SPL T           
Sbjct: 786  PQAPPALATPPLQALPSPPASFPGQ--------APFSPSASLPMSPLAT----------- 826

Query: 922  RDAEGTELSRRHNWTKPEPQAPVAWE----RVAPSNLPQGHPLPKSFSSPPSPSNKREEE 977
                            P PQAP        +V PS  P   P  ++   PP+P       
Sbjct: 827  ----------------PPPQAPPVLAAPLLQVPPS--PPASPTLQAPRRPPTPGPDTSVS 868

Query: 978  EEEFNFEVIP-PPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQL---PNAGPGAPP- 1032
                   + P PPP  S  P          G  SS   +   +LR     P  G  A P 
Sbjct: 869  GPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSS-ATSTPEELRGYDSGPEGGAAASPP 927

Query: 1033 ---------ALGFSRFPA-GARYAGAGGL----ERFSGGGRSLIKKRLYVGE------PH 1072
                        +SR PA    + GA G        +G G +     +Y  E      P 
Sbjct: 928  PDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPA 987

Query: 1073 RG---PGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHA-------PRLSL 1122
             G   PG   G +G   ++    G     P+  R+   G  P G L A        R  L
Sbjct: 988  PGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARL---GELPLGALQASVVQHLLSRTLL 1044

Query: 1123 EGAARGAAEAKHKAPGSADYGFAPAAGRSPYTTTRYG 1159
              AA GAA      PG A+ G      R+  +    G
Sbjct: 1045 LAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELG 1081



 Score =  117 bits (293), Expect = 7e-26
 Identities = 147/497 (29%), Positives = 188/497 (37%), Gaps = 86/497 (17%)

Query: 73  PRVRPL---LTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLR 129
           P V PL   LT  PL A  +  LA  +P  P           SSL+   L   SS+    
Sbjct: 475 PAVSPLSSPLTIHPLQALSS--LASHSPQAP----------LSSLIMPPLETQSSLAPPS 522

Query: 130 PGQYGQDLLIPPPP--PGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMA 187
                  L  PP    P  AP P Q  S P     L +PP  AP P    L+ PP P + 
Sbjct: 523 LQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCP----LQAPPSP-LT 577

Query: 188 PPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVP--APAPPAPASPHTV 245
            PPP    +++ P   + P++ +PP    P+PPL+ LA PPP  P     PP  A P   
Sbjct: 578 TPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPS-- 635

Query: 246 GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSP-AEPKGSALGPNPEPHLTFPRSFKV 304
                PP                     ASPP SP A P   A  PN          F  
Sbjct: 636 -----PP---------------------ASPPLSPLATPSPQA--PNALAVHLLQAPFSP 667

Query: 305 PPPTPVRT-----SSIPVQEAQEAPRKEEGATKKAPSRL-PLPPSFHIRPASQVYPDRAP 358
           PP  PV+      +S PV  +   P +   +    P ++ P PP+      S   P +AP
Sbjct: 668 PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP 727

Query: 359 EPDC--PGELKATAPASPRLGQSQSQADERAGTPPPAPPL----PPPAPPLPPPAPPLPP 412
            P    P ++  + PASP +  S       A  PP  PPL    P   PP PP + P+ P
Sbjct: 728 PPLAAPPLQVPPSPPASPPMSPS-------ATPPPRVPPLLAAPPLQVPPSPPASLPMSP 780

Query: 413 AAPPLPCAQKA-AHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLR 471
            A P P A  A A PP     +P    PA  P   P SP  +   +P+    P     L 
Sbjct: 781 LAKPPPQAPPALATPPLQALPSP----PASFPGQAPFSPSASLPMSPLATPPPQAPPVLA 836

Query: 472 NELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG-VPEK 530
             L              + R  PT  P +     GPRL    TL   P    PP   P  
Sbjct: 837 APLLQVPPSPPASPTLQAPRRPPTPGPDT--SVSGPRL----TLALAPGPPPPPSRSPSS 890

Query: 531 SLGGSSLTETEAAPSLT 547
           +L G  L    ++ + T
Sbjct: 891 TLSGPDLAGHSSSATST 907



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 128/445 (28%), Positives = 167/445 (37%), Gaps = 68/445 (15%)

Query: 73   PRVRPLLTFLPLNAQEN---HGLAVPTPSVPDDFADKEVTGTSSL-VNGNLRLYSSVGDL 128
            P+  P L   PL    +     LA P P  P   A   +    S   +  L   ++    
Sbjct: 592  PQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQ 651

Query: 129  RPGQYGQDLLIPP--PPPGPAPGPPQDISEPPGGSPLPSPPSTAPPP---PPLLLEPPPP 183
             P      LL  P  PPP P    P      P  SP  +PPS APP    PPL + P PP
Sbjct: 652  APNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPP 711

Query: 184  PSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPP----APPLAFLAPPPPPVP--APAPP 237
             S     PP+  + +PP   + P +  PP  +PP    +PP++  A PPP VP    APP
Sbjct: 712  AS-----PPMSPSATPPPQ-APPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPP 765

Query: 238  APASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPP-RSPAEPKGSALGPNP-EPH 295
                P        PP  +    S +A    QA    A+PP ++   P  S  G  P  P 
Sbjct: 766  LQVPPS-------PPASLP--MSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 816

Query: 296  LTFPRS-FKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP----------SF 344
             + P S    PPP      + P+   Q  P      T +AP R P P           + 
Sbjct: 817  ASLPMSPLATPPPQAPPVLAAPL--LQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTL 874

Query: 345  HIRPASQVYPDRAPE-----PDCPG-ELKATAPASPRLGQSQSQADERAGTPPPAPPLPP 398
             + P     P R+P      PD  G    AT+      G         A +PPP   L  
Sbjct: 875  ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAA 934

Query: 399  --PAPPLPPPAPPLP-PAAPPLPCAQKAAHPPAGF--------TKTPKSSSP---ALKPK 444
              PA     PAPPL    AP  P     A  P           T+ P+S++P   AL P 
Sbjct: 935  CHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPG 994

Query: 445  PNPPSPENTASS---APVDWRDPSQ 466
            P+P +    A++   A    R P Q
Sbjct: 995  PSPGTSGGKAAAGAGAGASSRSPKQ 1019



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 171/709 (24%), Positives = 232/709 (32%), Gaps = 103/709 (14%)

Query: 376  LGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPL--------------PCAQ 421
            +   + +A   A    PA   P    P PP +P  PP   P               P A+
Sbjct: 1    MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60

Query: 422  KAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGS 481
            +A     G    P+S+  A   +    S  N AS  P   R   +    +N     +   
Sbjct: 61   RAG--GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRG-ERAPPAKNTSPGPVSSP 117

Query: 482  RREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTP----------------- 524
             R     + RPGP        G+KG R+  +ET+    A + P                 
Sbjct: 118  GRASG--TTRPGPL-------GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT 168

Query: 525  PGVPEKSLG-GSSLTETEAAPSLTLPSV-DYIPQDSPTPSVRQIRNELEARLSSAAEKEA 582
            PG P  ++   S    TE       PS     P + P  SV           S AA +  
Sbjct: 169  PGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR-- 226

Query: 583  KPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPK-----AML 637
            +PS G    +P     R   + A    LS P       + T   P    QPK     A+ 
Sbjct: 227  RPSAGGGLQRP---ASRSLSSSA--TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALR 281

Query: 638  GPAI-PPKATPEPAIPPKATLWPATP-PKATLGPATPLKATSGPTTPLKATSGPAIASTA 695
             P + PP+    PA+ P ++   ATP P  T   A P+       TPL AT  P+    A
Sbjct: 282  PPQVTPPRKDAAPALGPLSSSPLATPSPSGT--KARPVPPPDNAATPLPATLPPS-PPLA 338

Query: 696  TTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFP 755
            T LP             P      P+ Q + +P       +P   T  P Q   S    P
Sbjct: 339  TPLPL-----------APPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIP 387

Query: 756  PKTSPGGGEVPCLYKP--HCHQSSLSREVAVVMPTLARGGA---AGPGEPVEVKEPPGLP 810
            P   P     P L  P      SSL    ++  PTL    +     P +       P  P
Sbjct: 388  PIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRP 447

Query: 811  AKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRD 870
            A  P  + P    L  P +  +    SP    L++       +++           SL  
Sbjct: 448  ASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQAL----------SSLAS 497

Query: 871  HSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELS 930
            HS QA  SS  I     T +S          A   +P    +P+   P L        L+
Sbjct: 498  HSPQAPLSS-LIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPL--QTASAPLT 554

Query: 931  RRHNWTKPEP-----QAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEV 985
              H  T P P     QAP +     P   P     P   + P   S   +         +
Sbjct: 555  TPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPL 614

Query: 986  IPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPAL 1034
              PPP+      PP  AL  L    SPP +    L  L    P AP AL
Sbjct: 615  ATPPPQ-----APPXLALPPLQAPPSPPAS--PPLSPLATPSPQAPNAL 656


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score =  148 bits (373), Expect = 3e-35
 Identities = 165/677 (24%), Positives = 226/677 (33%), Gaps = 94/677 (13%)

Query: 141  PPPPGPAPGPPQDISEPPGGSPLP------SPPSTAPPPPPLLLEPPPPPSMAPPPPPVL 194
            PP   P+P P    + PP  +P P      +PP T  P PP+     PPP+  P PP   
Sbjct: 1401 PPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPIST 1460

Query: 195  EALSPPHTLSSPSIPTP-PDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPG 253
                PP T  SP   TP P    P+PP       PPP   P+PP         T + PP 
Sbjct: 1461 TTTPPPTTTPSPPTTTPSPPTTTPSPPTT-TTTTPPPTTTPSPPTT-------TPITPP- 1511

Query: 254  GVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTS 313
                           A  T   P  +P+ P  +   P P    + P +  + PPT   T+
Sbjct: 1512 ---------------ASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPT--STT 1554

Query: 314  SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPAS 373
            ++P       P      T   P+  P PP+    P+        P P        T   +
Sbjct: 1555 TLPPTTTPSPP--PTTTTTPPPTTTPSPPT-TTTPSPPTITTTTPPPTTTPSPPTTTTTT 1611

Query: 374  PRLGQSQSQADERAGTPPPA-PPLPPPAPPLPPPAPPL--PPAAPPLPCAQKAAHPPAGF 430
            P    + S       TPP +   LPP   P PPP      PP   P P       PP   
Sbjct: 1612 PPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITT 1671

Query: 431  TKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSH 490
            T TP  ++    P    PSP  T  + P     PS         ++    S       + 
Sbjct: 1672 TTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTT- 1730

Query: 491  RPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPS 550
             P PT  P           P   T+ +LP   T   +    L  S    T +  S T P+
Sbjct: 1731 -PSPTTTPS----------PPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTPT 1779

Query: 551  VDYIP-------QDSPTPSVRQIRNELE-----------ARLSSAAEKEAKPSIGSLPPK 592
               +P        DS  P+  +   + E           A +S  A       IG L   
Sbjct: 1780 TPCVPLCNWTGWLDSGKPNFHKPGGDTELIGDVCGPGWAANISCRATMYPDVPIGQLGQT 1839

Query: 593  P--RLEGGRICENGADDDKLSKPVAKNL-----------PPQSTTLLPTTSLQPKAMLGP 639
                +  G IC+N         P+A  L             Q TT+  TT+  P      
Sbjct: 1840 VVCDVSVGLICKNEDQKPGGVIPMAFCLNYEINVQCCECVTQPTTMTTTTTENPTPPTTT 1899

Query: 640  AIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTP----------LKATSGP 689
             I    T  P   P  T  P T P  T    TP    +G  TP          +  T  P
Sbjct: 1900 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 1959

Query: 690  AIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGAR 749
                T TT P TT+  +    + P G  + P +  ++T +      +P+      T    
Sbjct: 1960 TGTQTPTTTPITTTTTVTPTPT-PTG-TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2017

Query: 750  SSAAFPPKTSPGGGEVP 766
            ++    P  +P G + P
Sbjct: 2018 TTTTVTPTPTPTGTQTP 2034



 Score =  104 bits (259), Expect = 6e-22
 Identities = 140/686 (20%), Positives = 215/686 (31%), Gaps = 81/686 (11%)

Query: 140  PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPS--MAPPP-----PP 192
            P PP    P PP   +  P  +  PSPP+T    PP    P PP +  + PP      PP
Sbjct: 1578 PSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPP 1637

Query: 193  VLEALSPPHTLSSP---SIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRL 249
                  PP T ++P   + P+PP    P+PP+      PPP   P+ P   +P    T +
Sbjct: 1638 TTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPIT-TTTTPPPTTTPSSPITTTPSPPTTTM 1696

Query: 250  FPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTP 309
              P   T   S +      +  T  SPP +          P+P P  T          +P
Sbjct: 1697 TTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSP-PTTTMTTLPPTTTSSP 1755

Query: 310  VRTSSIPVQEAQEAPRKEEGATKKAPSRLPL----------PPSFHIRP----------- 348
            + T+ +P              T   P  +PL           P+FH +P           
Sbjct: 1756 LTTTPLPPSITPPTFSPFSTTTPTTPC-VPLCNWTGWLDSGKPNFH-KPGGDTELIGDVC 1813

Query: 349  ----ASQVYPDRAPEPDCP-GELKATAPASPRLGQSQSQADERAG--------------- 388
                A+ +       PD P G+L  T      +G      D++ G               
Sbjct: 1814 GPGWAANISCRATMYPDVPIGQLGQTVVCDVSVGLICKNEDQKPGGVIPMAFCLNYEINV 1873

Query: 389  ------TPPPAPPLPPPAPPLPPPAPPL--PPAAPPLPCAQKAAHPPAGFTKTPKSSSPA 440
                  T P          P PP   P+       P P       P    T TP +++  
Sbjct: 1874 QCCECVTQPTTMTTTTTENPTPPTTTPITTTTTVTPTPTPTGTQTP----TTTPITTTTT 1929

Query: 441  LKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQS 500
            + P P P   + T ++ P+                            ++  P PT     
Sbjct: 1930 VTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT----- 1983

Query: 501  KEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPT 560
              G + P      T  ++    TP G    +   + +T T        P+    P  +P 
Sbjct: 1984 --GTQTPTTTPITTTTTVTPTPTPTGTQTPTT--TPITTTTTVTPTPTPTGTQTPTTTPI 2039

Query: 561  PSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPP 620
             +   +        +         +  ++ P P   G +           +  V     P
Sbjct: 2040 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ--TPTTTPITTTTTVTPTPTP 2097

Query: 621  QSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPT 680
              T    TT +     + P   P  T  P   P  T    TP     G  TP       T
Sbjct: 2098 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2157

Query: 681  TPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEA 740
            T +  T  P    T TT P TT+  +    + P G  + P +  ++T +      +P+  
Sbjct: 2158 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-PTG-TQTPTTTPITTTTTVTPTPTPTGT 2215

Query: 741  TRLPTQGARSSAAFPPKTSPGGGEVP 766
                T    ++    P  +P G + P
Sbjct: 2216 QTPTTTPITTTTTVTPTPTPTGTQTP 2241



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 98/442 (22%), Positives = 133/442 (30%), Gaps = 84/442 (19%)

Query: 331  TKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTP 390
            T   P+  P PP     P S         P  P     T P +       +       T 
Sbjct: 1398 TPSPPTTTPSPP-----PTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTT 1452

Query: 391  PPAPPL------PPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPK 444
             P+PP+      PP   P PP   P PP   P P       PP   T +P +++P   P 
Sbjct: 1453 TPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPA 1512

Query: 445  PNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGK 504
                 P  T  S P                              +  P PT  P      
Sbjct: 1513 STTTLPPTTTPSPPTT---------------------------TTTTPPPTTTPSPPTTT 1545

Query: 505  KGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVR 564
              P  P   T    P   T P  P  +      T T + P+ T PS   I   +P P+  
Sbjct: 1546 --PITPPTSTTTLPPT--TTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTT 1601

Query: 565  QIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTT 624
                             + P+  +  P P                 + P+    P  +TT
Sbjct: 1602 P----------------SPPTTTTTTPPPTT---------TPSPPTTTPITP--PTSTTT 1634

Query: 625  LLPTTSLQPKAMLGPAIPPKATPEP--AIPPKATLWPATPPKATLGPATPLKATSGPTTP 682
            L PTT+  P        PP  TP P     P   +   T P  T  P++P+  T  P T 
Sbjct: 1635 LPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTT 1694

Query: 683  LKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEA-T 741
               T  P    ++    TTT           +     P    ++TPS       P+   T
Sbjct: 1695 TMTTPSPTTTPSSPITTTTTPS---------STTTPSPPPTTMTTPSPTTTPSPPTTTMT 1745

Query: 742  RLP---TQGARSSAAFPPKTSP 760
             LP   T    ++   PP  +P
Sbjct: 1746 TLPPTTTSSPLTTTPLPPSITP 1767



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 98/399 (24%), Positives = 121/399 (30%), Gaps = 82/399 (20%)

Query: 389  TPPPAPPLPPPA-----PPLPPPAPPL------PPAAPPLPCAQKAAHPPAGFTKTPKSS 437
            +PP   P PPP      PP   P+PP       PP   P P       PP   T +P  S
Sbjct: 1400 SPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPIS 1459

Query: 438  SPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVA 497
            +    P    PSP  T  S P     P                        +  P PT  
Sbjct: 1460 TTTTPPPTTTPSPPTTTPSPPTTTPSPPTTT--------------------TTTPPPTTT 1499

Query: 498  PQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQD 557
            P           P   T ++ PA  T   +P  +      T T   P  T PS       
Sbjct: 1500 PS----------PPTTTPITPPASTTT--LPPTTTPSPPTTTTTTPPPTTTPSPPTTTPI 1547

Query: 558  SPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKN 617
            +P  S           L         P+  + PP                   S P    
Sbjct: 1548 TPPTST--------TTLPPTTTPSPPPTTTTTPPPTTTP--------------SPPTTTT 1585

Query: 618  LPPQS---TTLLPTTSLQPKAMLGPAIPPKATPE-----PAIPPKA--TLWPATPPKATL 667
              P +   TT  PTT+  P        PP  TP      P  PP +  TL P T P    
Sbjct: 1586 PSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPP 1645

Query: 668  GPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVST 727
               T    T+ P+ P   T  P I +T T  PTTT        S P      P +  ++T
Sbjct: 1646 TTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTT-------PSSPITTTPSPPTTTMTT 1698

Query: 728  PSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP 766
            PS      SP   T  P+     S      T+P     P
Sbjct: 1699 PSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTP 1737



 Score = 84.7 bits (208), Expect = 5e-16
 Identities = 109/485 (22%), Positives = 137/485 (28%), Gaps = 99/485 (20%)

Query: 173  PPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVP 232
            P    +  P PP+  P PPP      PP T  SP   T                 PPP  
Sbjct: 1391 PMDKCITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTT--------------TTTPPPTT 1436

Query: 233  APAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP 292
             P+PP       + T   PP   T               T   PP +   P  +   P+P
Sbjct: 1437 TPSPP-------ITTTTTPPPTTTP--------SPPISTTTTPPPTTTPSPPTTT--PSP 1479

Query: 293  EPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQV 352
                  P +     P P  T S P       P      T   P+  P PP+      +  
Sbjct: 1480 PTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPAS---TTTLPPTTTPSPPT-----TTTT 1531

Query: 353  YPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP---APP 409
             P     P  P     T P S                PP   P PPP     PP    P 
Sbjct: 1532 TPPPTTTPSPPTTTPITPPTSTTT------------LPPTTTPSPPPTTTTTPPPTTTPS 1579

Query: 410  LPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEK 469
             P    P P       PP   T +P +++    P    PSP  T    P     P+    
Sbjct: 1580 PPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITP-----PTSTTT 1634

Query: 470  LRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPE 529
            L                       PT  P               T  + P   T P  P 
Sbjct: 1635 LP----------------------PTTTPSPPP-----------TTTTTPPPTTTPSPPT 1661

Query: 530  KSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSL 589
             +     +T T   P  T PS       SP P+            SS       PS  + 
Sbjct: 1662 TTTPSPPITTTTTPPPTTTPSSPITTTPSP-PTTTMTTPSPTTTPSSPITTTTTPSSTTT 1720

Query: 590  PPKPRLEGGRICENGADDDKLSKPVAK--NLPPQSTTLLPTTSLQPKAMLGPAIPPKATP 647
            P  P           +     S P      LPP +T+   TT+  P ++  P   P +T 
Sbjct: 1721 PSPPPTT----MTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFSTT 1776

Query: 648  EPAIP 652
             P  P
Sbjct: 1777 TPTTP 1781



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 110/459 (23%), Positives = 142/459 (30%), Gaps = 83/459 (18%)

Query: 258  WKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPV 317
            W  D  +       T  SPP +          P+P    T        P  P+ T++ P 
Sbjct: 1390 WPMDKCITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPP 1449

Query: 318  QEAQEAP------RKEEGATKKAPSRLPLPPSFHIRP--ASQVYPDRAPEPDCPGELKAT 369
                 +P            T   P+  P PP+    P   +   P     P  P     T
Sbjct: 1450 PTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPIT 1509

Query: 370  APASPRL---GQSQSQADERAGTPPP-APPLPPPAPPLPPP--APPLPPAAPPLPCAQKA 423
             PAS        + S       TPPP   P PP   P+ PP     LPP   P P     
Sbjct: 1510 PPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSP----- 1564

Query: 424  AHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRR 483
              PP   T  P +++P+  P    PSP    ++ P     PS                  
Sbjct: 1565 --PPTTTTTPPPTTTPS-PPTTTTPSPPTITTTTPPPTTTPS------------------ 1603

Query: 484  EDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAA 543
                 +  P PT  P        P  P   T    P   T P  P  +      T T + 
Sbjct: 1604 PPTTTTTTPPPTTTPSPP--TTTPITPPTSTTTLPPT--TTPSPPPTTTTTPPPTTTPSP 1659

Query: 544  PSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICEN 603
            P+ T PS       +P P+            S      + P+     P P          
Sbjct: 1660 PTTTTPSPPITTTTTPPPTT--------TPSSPITTTPSPPTTTMTTPSPTTTP------ 1705

Query: 604  GADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPP 663
                   S P+     P STT   T S  P  M  P+  P  TP P      TL    PP
Sbjct: 1706 -------SSPITTTTTPSSTT---TPSPPPTTMTTPS--PTTTPSPPTTTMTTL----PP 1749

Query: 664  KATLGPATPLKATSGPTTPL-KATSGPAIASTATTLPTT 701
              T  P T        TTPL  + + P  +  +TT PTT
Sbjct: 1750 TTTSSPLT--------TTPLPPSITPPTFSPFSTTTPTT 1780



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 145/795 (18%), Positives = 233/795 (29%), Gaps = 55/795 (6%)

Query: 60   TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119
            TV+ + T T    P   P+ T   +          PTP+         +T T+++     
Sbjct: 3562 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 3614

Query: 120  RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPP 174
               +      P      +   P P G        I+     +P P+P     P+T P   
Sbjct: 3615 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3674

Query: 175  PLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP 234
               + P P P+    P       + P T ++   PTP       P    +       P P
Sbjct: 3675 TTTVTPTPTPTGTQTPT------TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3728

Query: 235  APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PN 291
             P    +P T      P    T         G Q   T      +   P  +  G   P 
Sbjct: 3729 TPTGTQTPTTT-----PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3783

Query: 292  PEPHLTFPRSFKVPPPTPVRT-SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350
              P  T       P PT  +T ++ P+               + P+  P+  +  + P  
Sbjct: 3784 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3843

Query: 351  QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410
                 + P    P     T   +P    +Q+       T     P P P     P   P+
Sbjct: 3844 TPTGTQTPTTT-PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3902

Query: 411  PPAAP--PLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQME 468
                   P P       P    T TP +++  + P P P   + T ++ P+         
Sbjct: 3903 TTTTTVTPTPTPTGTQTP----TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT 3957

Query: 469  KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528
                               ++  P PT       G + P      T  ++    TP G  
Sbjct: 3958 PTPTGTQTPTTTPITTTTTVTPTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQ 4010

Query: 529  EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588
              +   + +T T        P+    P  +P  +   +        +         +  +
Sbjct: 4011 TPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 4068

Query: 589  LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648
            + P P   G +           +  V     P  T    TT +     + P   P  T  
Sbjct: 4069 VTPTPTPTGTQTPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 4126

Query: 649  PAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAE 708
            P   P  T    TP     G  TP       TT +  T  P    T TT P TT+  +  
Sbjct: 4127 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 4186

Query: 709  KDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCL 768
              + P G    P +   + P       +P   +  P     +S+     T+     +   
Sbjct: 4187 TPT-PTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTT-----LLST 4240

Query: 769  YKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAK---PPASAQPTDELLR 825
              P    +S +       PT   GG      P     PPG P +     +S+ PT   ++
Sbjct: 4241 LPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQ 4300

Query: 826  HPVTGEVVERGSPMA 840
               T       +P++
Sbjct: 4301 TTTTSAWTPTPTPLS 4315



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 140/698 (20%), Positives = 220/698 (31%), Gaps = 72/698 (10%)

Query: 60   TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119
            TV+ + T T    P   P+ T   +          PTP+         +T T+++     
Sbjct: 3677 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 3729

Query: 120  RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPP 174
               +      P      +   P P G        I+     +P P+P     P+T P   
Sbjct: 3730 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3789

Query: 175  PLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP 234
               + P P P+    P       + P T ++   PTP       P    +       P P
Sbjct: 3790 TTTVTPTPTPTGTQTPT------TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3843

Query: 235  APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PN 291
             P    +P T      P    T         G Q   T      +   P  +  G   P 
Sbjct: 3844 TPTGTQTPTTT-----PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3898

Query: 292  PEPHLTFPRSFKVPPPTPVRT-SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350
              P  T       P PT  +T ++ P+               + P+  P+  +  + P  
Sbjct: 3899 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3958

Query: 351  QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410
                 + P    P     T   +P    +Q+       T     P P P     P   P+
Sbjct: 3959 TPTGTQTPTTT-PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 4017

Query: 411  PPAAP--PLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQME 468
                   P P       P    T TP +++  + P P P   + T ++ P+         
Sbjct: 4018 TTTTTVTPTPTPTGTQTP----TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT 4072

Query: 469  KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528
                               ++  P PT       G + P      T  ++    TP G  
Sbjct: 4073 PTPTGTQTPTTTPITTTTTVTPTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQ 4125

Query: 529  EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588
              +   + +T T        P+    P  +P  +   +        +         +  +
Sbjct: 4126 TPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 4183

Query: 589  LPPKPRLEGGRICENGADDDKLSKPVAK----NLPPQSTTLLPTTSLQPKAMLGPAIPPK 644
            + P P   G    + G      + P+A+    N PP+S+T  P TS    + L  +    
Sbjct: 4184 VTPTPTPTG---TQTGPPTHTSTAPIAELTTSNPPPESST--PQTSRSTSSPLTESTTLL 4238

Query: 645  ATPEPAIPPKATLWPATP--PKATLGPAT----PLKATSGPTTPLKATS-GPAIASTATT 697
            +T  PAI   +T  P+TP  P  T G  T    P   TS P TP + T+ G + A T +T
Sbjct: 4239 STLPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPST 4298

Query: 698  LPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEG 735
            + TTT+                P    +STPS  R  G
Sbjct: 4299 VQTTTTSAWT------------PTPTPLSTPSIIRTTG 4324



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 171/927 (18%), Positives = 270/927 (29%), Gaps = 78/927 (8%)

Query: 60   TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119
            TV+ + T T    P   P+ T   +          PTP+         +T T+++     
Sbjct: 3447 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 3499

Query: 120  RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPP 174
               +      P      +   P P G        I+     +P P+P     P+T P   
Sbjct: 3500 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3559

Query: 175  PLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP 234
               + P P P+    P       + P T ++   PTP       P    +       P P
Sbjct: 3560 TTTVTPTPTPTGTQTPT------TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3613

Query: 235  APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PN 291
             P    +P T      P    T         G Q   T      +   P  +  G   P 
Sbjct: 3614 TPTGTQTPTTT-----PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3668

Query: 292  PEPHLTFPRSFKVPPPTPVRT-SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350
              P  T       P PT  +T ++ P+               + P+  P+  +  + P  
Sbjct: 3669 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3728

Query: 351  QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410
                 + P    P     T   +P    +Q+       T     P P P     P   P+
Sbjct: 3729 TPTGTQTPTTT-PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3787

Query: 411  PPAAP--PLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQME 468
                   P P       P    T TP +++  + P P P   + T ++ P+         
Sbjct: 3788 TTTTTVTPTPTPTGTQTP----TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT 3842

Query: 469  KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528
                               ++  P PT       G + P      T  ++    TP G  
Sbjct: 3843 PTPTGTQTPTTTPITTTTTVTPTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQ 3895

Query: 529  EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588
              +   + +T T        P+    P  +P  +   +        +         +  +
Sbjct: 3896 TPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3953

Query: 589  LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648
            + P P   G +           +  V     P  T    TT +     + P   P  T  
Sbjct: 3954 VTPTPTPTGTQTPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 4011

Query: 649  PAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAE 708
            P   P  T    TP     G  TP       TT +  T  P    T TT P TT+  +  
Sbjct: 4012 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 4071

Query: 709  KDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCL 768
              + P G  + P +  ++T +      +P+      T    ++    P  +P G + P  
Sbjct: 4072 TPT-PTG-TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP-- 4127

Query: 769  YKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQ-PTDELLRHP 827
                   ++       V PT    G   P            P   P   Q PT      P
Sbjct: 4128 ------TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT----P 4177

Query: 828  VTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLP-GSLRDHSHQAEASSDSIFHSQ 886
            +T       +P             G   G     S+ P   L   +   E+S+     S 
Sbjct: 4178 ITTTTTVTPTP----------TPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRST 4227

Query: 887  GTP--NSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPV 944
             +P   S T++  LP   E  S      P       G    G  LS   + T   P  P 
Sbjct: 4228 SSPLTESTTLLSTLPPAIEMTSTAPPSTPTAPTTTSG----GHTLSPPPSTTTSPPGTPT 4283

Query: 945  AWERVAPSNLPQGHPLPKSFSSPPSPS 971
                   S+ P    +  + +S  +P+
Sbjct: 4284 RGTTTGSSSAPTPSTVQTTTTSAWTPT 4310



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 131/718 (18%), Positives = 212/718 (29%), Gaps = 48/718 (6%)

Query: 60   TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119
            TV+ + T T    P   P+ T   +          PTP+         +T T+++     
Sbjct: 2090 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 2142

Query: 120  RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPP 174
               +      P      +   P P G        I+     +P P+P     P+T P   
Sbjct: 2143 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2202

Query: 175  PLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP 234
               + P P P+    P       + P T ++   PTP       P    +       P P
Sbjct: 2203 TTTVTPTPTPTGTQTPT------TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2256

Query: 235  APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PN 291
             P    +P T      P    T         G Q   T      +   P  +  G   P 
Sbjct: 2257 TPTGTQTPTTT-----PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2311

Query: 292  PEPHLTFPRSFKVPPPTPVRT-SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350
              P  T       P PT  +T ++ P+               + P+  P+  +  + P  
Sbjct: 2312 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2371

Query: 351  QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410
                 + P    P     T   +P    +Q+       T     P P P     P   P+
Sbjct: 2372 TPTGTQTP-TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2430

Query: 411  --PPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQME 468
                   P P       P    T TP +++  + P P P   + T ++ P+         
Sbjct: 2431 TTTTTVTPTPTPTGTQTP----TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT 2485

Query: 469  KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528
                               ++  P PT       G + P      T  ++    TP G  
Sbjct: 2486 PTPTGTQTPTTTPITTTTTVTPTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQ 2538

Query: 529  EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588
              +   + +T T        P+    P  +P  +   +        +         +  +
Sbjct: 2539 TPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2596

Query: 589  LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648
            + P P   G +           +  V     P  T    TT +     + P   P  T  
Sbjct: 2597 VTPTPTPTGTQ--TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2654

Query: 649  PAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAE 708
            P   P  T    TP     G  TP       TT +  T  P    T TT P TT+  +  
Sbjct: 2655 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 2714

Query: 709  KDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP 766
              + P G  + P +  ++T +      +P+      T    ++    P  +P G + P
Sbjct: 2715 TPT-PTG-TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2770



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 131/718 (18%), Positives = 212/718 (29%), Gaps = 48/718 (6%)

Query: 60   TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119
            TV+ + T T    P   P+ T   +          PTP+         +T T+++     
Sbjct: 2550 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 2602

Query: 120  RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPP 174
               +      P      +   P P G        I+     +P P+P     P+T P   
Sbjct: 2603 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2662

Query: 175  PLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP 234
               + P P P+    P       + P T ++   PTP       P    +       P P
Sbjct: 2663 TTTVTPTPTPTGTQTPT------TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2716

Query: 235  APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PN 291
             P    +P T      P    T         G Q   T      +   P  +  G   P 
Sbjct: 2717 TPTGTQTPTTT-----PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2771

Query: 292  PEPHLTFPRSFKVPPPTPVRT-SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350
              P  T       P PT  +T ++ P+               + P+  P+  +  + P  
Sbjct: 2772 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2831

Query: 351  QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410
                 + P    P     T   +P    +Q+       T     P P P     P   P+
Sbjct: 2832 TPTGTQTP-TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2890

Query: 411  --PPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQME 468
                   P P       P    T TP +++  + P P P   + T ++ P+         
Sbjct: 2891 TTTTTVTPTPTPTGTQTP----TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT 2945

Query: 469  KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528
                               ++  P PT       G + P      T  ++    TP G  
Sbjct: 2946 PTPTGTQTPTTTPITTTTTVTPTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQ 2998

Query: 529  EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588
              +   + +T T        P+    P  +P  +   +        +         +  +
Sbjct: 2999 TPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3056

Query: 589  LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648
            + P P   G +           +  V     P  T    TT +     + P   P  T  
Sbjct: 3057 VTPTPTPTGTQ--TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3114

Query: 649  PAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAE 708
            P   P  T    TP     G  TP       TT +  T  P    T TT P TT+  +  
Sbjct: 3115 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 3174

Query: 709  KDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP 766
              + P G  + P +  ++T +      +P+      T    ++    P  +P G + P
Sbjct: 3175 TPT-PTG-TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 3230



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 131/718 (18%), Positives = 212/718 (29%), Gaps = 48/718 (6%)

Query: 60   TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119
            TV+ + T T    P   P+ T   +          PTP+         +T T+++     
Sbjct: 3010 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 3062

Query: 120  RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPP 174
               +      P      +   P P G        I+     +P P+P     P+T P   
Sbjct: 3063 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3122

Query: 175  PLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP 234
               + P P P+    P       + P T ++   PTP       P    +       P P
Sbjct: 3123 TTTVTPTPTPTGTQTPT------TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3176

Query: 235  APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PN 291
             P    +P T      P    T         G Q   T      +   P  +  G   P 
Sbjct: 3177 TPTGTQTPTTT-----PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3231

Query: 292  PEPHLTFPRSFKVPPPTPVRT-SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350
              P  T       P PT  +T ++ P+               + P+  P+  +  + P  
Sbjct: 3232 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3291

Query: 351  QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410
                 + P    P     T   +P    +Q+       T     P P P     P   P+
Sbjct: 3292 TPTGTQTP-TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3350

Query: 411  --PPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQME 468
                   P P       P    T TP +++  + P P P   + T ++ P+         
Sbjct: 3351 TTTTTVTPTPTPTGTQTP----TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT 3405

Query: 469  KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528
                               ++  P PT       G + P      T  ++    TP G  
Sbjct: 3406 PTPTGTQTPTTTPITTTTTVTPTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQ 3458

Query: 529  EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588
              +   + +T T        P+    P  +P  +   +        +         +  +
Sbjct: 3459 TPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3516

Query: 589  LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648
            + P P   G +           +  V     P  T    TT +     + P   P  T  
Sbjct: 3517 VTPTPTPTGTQ--TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3574

Query: 649  PAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAE 708
            P   P  T    TP     G  TP       TT +  T  P    T TT P TT+  +  
Sbjct: 3575 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 3634

Query: 709  KDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP 766
              + P G  + P +  ++T +      +P+      T    ++    P  +P G + P
Sbjct: 3635 TPT-PTG-TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 3690



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 118/637 (18%), Positives = 188/637 (29%), Gaps = 41/637 (6%)

Query: 141  PPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPPPLLLEPPPPPSMAPPPPPVLE 195
            P P G        I+     +P P+P     P+T P      + P P P+    P     
Sbjct: 1934 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT---- 1989

Query: 196  ALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGV 255
              + P T ++   PTP       P    +       P P P    +P T      P    
Sbjct: 1990 --TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-----PITTT 2042

Query: 256  TKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PNPEPHLTFPRSFKVPPPTPVRT 312
            T         G Q   T      +   P  +  G   P   P  T       P PT  +T
Sbjct: 2043 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2102

Query: 313  -SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAP 371
             ++ P+               + P+  P+  +  + P       + P    P     T  
Sbjct: 2103 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP-TTTPITTTTTVT 2161

Query: 372  ASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL--PPAAPPLPCAQKAAHPPAG 429
             +P    +Q+       T     P P P     P   P+       P P       P   
Sbjct: 2162 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP--- 2218

Query: 430  FTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLS 489
             T TP +++  + P P P   + T ++ P+                            ++
Sbjct: 2219 -TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2276

Query: 490  HRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLP 549
              P PT       G + P      T  ++    TP G    +   + +T T        P
Sbjct: 2277 PTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQTPTT--TPITTTTTVTPTPTP 2327

Query: 550  SVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDK 609
            +    P  +P  +   +        +         +  ++ P P   G +          
Sbjct: 2328 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ--TPTTTPIT 2385

Query: 610  LSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGP 669
             +  V     P  T    TT +     + P   P  T  P   P  T    TP     G 
Sbjct: 2386 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2445

Query: 670  ATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPS 729
             TP       TT +  T  P    T TT P TT+  +    + P G  + P +  ++T +
Sbjct: 2446 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-PTG-TQTPTTTPITTTT 2503

Query: 730  QARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP 766
                  +P+      T    ++    P  +P G + P
Sbjct: 2504 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2540



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 56/215 (26%), Positives = 73/215 (33%), Gaps = 23/215 (10%)

Query: 610  LSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGP 669
            + K +    PP +T   P TS          +PP  TP    PP  T    T P  T  P
Sbjct: 1392 MDKCITTPSPPTTTPSPPPTST-------TTLPPTTTPS---PPTTT---TTTPPPTTTP 1438

Query: 670  ATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPS 729
            + P+  T+ P  P   T  P I++T T  PTTT        S P   P  P +   + P 
Sbjct: 1439 SPPITTTTTP--PPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPP 1496

Query: 730  QARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMP-- 787
                  +PS  T  P     S+   PP T+P          P     S      +  P  
Sbjct: 1497 TT----TPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTS 1552

Query: 788  --TLARGGAAGPGEPVEVKEPPGLPAKPPASAQPT 820
              TL       P        PP     PP +  P+
Sbjct: 1553 TTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPS 1587



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 89/382 (23%), Positives = 121/382 (31%), Gaps = 80/382 (20%)

Query: 60   TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119
            TV+ + T T    P   P+ T   +          PTP+         +T T+++     
Sbjct: 4091 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 4143

Query: 120  RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLE 179
               +      P      +   P P G        I+     +P P+P  T   PP     
Sbjct: 4144 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTGPPTHTST 4203

Query: 180  PPPPPSMAPPPPPVLEALSPPHTLSSPSIP-----TPPDFIPPAPPLAFLAPPPPPVPAP 234
             P        PPP     S P T  S S P     T    +PPA  +   APP  P    
Sbjct: 4204 APIAELTTSNPPP---ESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTPT--- 4257

Query: 235  APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAE--PKGSALGPNP 292
            AP   +  HT    L PP                  +T  SPP +P      GS+  P P
Sbjct: 4258 APTTTSGGHT----LSPP-----------------PSTTTSPPGTPTRGTTTGSSSAPTP 4296

Query: 293  EPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHI------ 346
                T   S   P PTP+ T SI                 +     P P S  I      
Sbjct: 4297 STVQTTTTSAWTPTPTPLSTPSII----------------RTTGLRPYPSSVLICCVLND 4340

Query: 347  ---RPASQVYPDRAPEP--------DCPGEL-KATAPASPRLGQSQSQADERAGTPPPAP 394
                P  +VY     +          C  E    + P++P    + S++     TP P+ 
Sbjct: 4341 TYYAPGEEVYNGTYGDTCYFVNCSLSCTLEFYNWSCPSTPSPTPTPSKS-----TPTPSK 4395

Query: 395  PLPPPAPPLPPPAPPLPPAAPP 416
            P   P+ P P   PP  P   P
Sbjct: 4396 PSSTPSKPTPGTKPPECPDFDP 4417



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 17/49 (34%), Positives = 21/49 (42%), Gaps = 7/49 (14%)

Query: 141  PPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPP 189
            P  P P P P +        +P PS PS+ P  P    +PP  P   PP
Sbjct: 4377 PSTPSPTPTPSK-------STPTPSKPSSTPSKPTPGTKPPECPDFDPP 4418


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score =  137 bits (346), Expect = 5e-32
 Identities = 131/376 (34%), Positives = 151/376 (40%), Gaps = 76/376 (20%)

Query: 130  PGQYGQDLLIPPPPPGPAPG--PPQDISEPPGGSPLPSPP---STAPPPPPL--LLEPPP 182
            P   G ++L PPPPP P  G  PP  +   PG   LP PP   +  PPPPPL     PPP
Sbjct: 900  PPLQGTEMLPPPPPPLPGAGIPPPPPL---PGAGILPLPPLPGAGIPPPPPLPGAAIPPP 956

Query: 183  PP---SMAPPPPPVLEA-LSPPHTLSSPSIPTPPDF----IPPAPPLAFLA-PPPPPVP- 232
            PP   +  P PPP+  A + PP  L    IP PP      IPP PPL     PPPPP+P 
Sbjct: 957  PPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1016

Query: 233  APAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP 292
            A  PP P  P   G  + PP                     A  P  P  P      P P
Sbjct: 1017 AGIPPPPPLP---GAGIPPP----------------PPLPGAGIPPPPPLPGAGIPPPPP 1057

Query: 293  EPHLTFP-----RSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLP---LPPSF 344
             P    P         +PPP P+  + IP       P    GA    P  LP   +PP  
Sbjct: 1058 LPGAGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPGVGIPPPP 1111

Query: 345  HIRPASQVYPDR-------APEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLP 397
             + P + + P          P P  PG      P  PR+G         AG PPP PPLP
Sbjct: 1112 PL-PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPP-PPLP 1169

Query: 398  ----PPAPPLP----PPAPPLP----PAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKP 445
                PP PPLP    PP PPLP    P  PPLP A     PP      P + +P L P  
Sbjct: 1170 GAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPG 1229

Query: 446  N--PPSPENTASSAPV 459
               PP P    S  P+
Sbjct: 1230 TGIPPPPLLPVSGPPL 1245



 Score =  112 bits (279), Expect = 3e-24
 Identities = 116/338 (34%), Positives = 125/338 (36%), Gaps = 60/338 (17%)

Query: 139  IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAP----PPPPLLLEPPPPP----SMAPPP 190
            IP PPP P     +  S  PG   +P PP   P    P  P    P PPP     M PPP
Sbjct: 855  IPSPPPLPCT---ESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPP 911

Query: 191  PPVLEALSPPHTLSSPSIPTPPDFIPPAPPL--AFLAPPPPPVPAPAPPAPASPHTVGTR 248
            PP L     P     P  P P   I P PPL  A + PPPPP+P  A P P      G  
Sbjct: 912  PPPLPGAGIP-----PPPPLPGAGILPLPPLPGAGI-PPPPPLPGAAIPPPPPLPGAGIP 965

Query: 249  LFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT 308
            L PP           L G       A  P  P  P      P P P         +PPP 
Sbjct: 966  LPPPLPGAGIPPPPPLPG-------AGIPPPPPLPGAGIPPPPPLP------GAGIPPPP 1012

Query: 309  PVRTSSIPVQEAQEAPRKEEGATKKAPSRLP---LPPSFHIRPASQVYPDRAPEPDCPGE 365
            P+  + IP       P    GA    P  LP   +PP     P         P P  PG 
Sbjct: 1013 PLPGAGIP------PPPPLPGAGIPPPPPLPGAGIPP-----PPPLPGAGIPPPPPLPGA 1061

Query: 366  LKATAPASPRLGQSQSQADERAGTPPPAPPLP----PPAPPLP----PPAPPLP----PA 413
                 P  P  G         AG PPP PPLP    PP PPLP    PP PPLP    P 
Sbjct: 1062 GIPPPPPLPGAGIPPPPPLPGAGIPPP-PPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPP 1120

Query: 414  APPLPCAQKAAHPP-AGFTKTPKSSSPALKPKPNPPSP 450
             PPLP A     PP  G    P    P +   P PP P
Sbjct: 1121 PPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLP 1158



 Score =  107 bits (267), Expect = 7e-23
 Identities = 106/310 (34%), Positives = 118/310 (38%), Gaps = 52/310 (16%)

Query: 139  IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTA--PPPPPLLLE--PPPPP---SMAPPPP 191
            IPPPPP P  G P     P  G P P P   A  PPPPPL     PPPPP   +  PPPP
Sbjct: 986  IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1045

Query: 192  PVLEA-LSPPHTLSSPSIPTPPDF----IPPAPPLAFLA-PPPPPVPAPAPPAPASPHTV 245
            P+  A + PP  L    IP PP      IPP PPL     PPPPP+P    P P     V
Sbjct: 1046 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGV 1105

Query: 246  GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVP 305
            G    PP           L G       A  P  P  P      P P P +       +P
Sbjct: 1106 GIPPPPPLPGAGIPPPPPLPG-------AGIPPPPPLPGAGIPPPPPLPRVG------IP 1152

Query: 306  PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLP---LPPSFHIRPASQVYPDRAPEPDC 362
            PP P+  + IP       P    GA    P  LP   +PP     P         P P  
Sbjct: 1153 PPPPLPGAGIP------PPPPLPGAGIPPPPPLPGVGIPP-----PPPLPGVGIPPPPPL 1201

Query: 363  PGELKATAPASPRLGQSQSQADERAGTPPPAPPLP---PPAPPLPPPAPPLPP--AAPPL 417
            PG      P  P +G   + A       PP PP     PP P LP   PPL P   +  L
Sbjct: 1202 PGAGIPPPPPLPGMGIPPAPA-------PPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTL 1254

Query: 418  PCAQKAAHPP 427
            P  Q     P
Sbjct: 1255 PTPQVCGFLP 1264



 Score =  105 bits (263), Expect = 2e-22
 Identities = 170/640 (26%), Positives = 207/640 (32%), Gaps = 176/640 (27%)

Query: 140  PPPPPGPAPGP-------------PQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSM 186
            PP PPG   GP             P+ IS            S  PPPP LL         
Sbjct: 767  PPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPG 826

Query: 187  APPPPPVLEALSPPHTLS-------SPSIPTPP-----DFIPPAPPLAFLAPPPPPVPA- 233
            + PP  +       H  S       S +IP+PP     +     P L  + PPPPP+P  
Sbjct: 827  SQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGM 886

Query: 234  -----PAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSAL 288
                 P+   P  P   GT + PP           L G       A  P  P  P    L
Sbjct: 887  TVPTLPSTAIPQPPPLQGTEMLPP-------PPPPLPG-------AGIPPPPPLPGAGIL 932

Query: 289  GPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRP 348
               P P         +PPP P+  ++IP       P    GA       +PLPP     P
Sbjct: 933  PLPPLP------GAGIPPPPPLPGAAIP------PPPPLPGA------GIPLPPPL---P 971

Query: 349  ASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLP----PPAPPLP 404
             + +     P P  PG      P  P  G         AG PPP PPLP    PP PPLP
Sbjct: 972  GAGI----PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP-PPLPGAGIPPPPPLP 1026

Query: 405  ----PPAPPLP----PAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPN---PPSPENT 453
                PP PPLP    P  PPLP A     PP      P +  P   P P    PP P   
Sbjct: 1027 GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP-----LPGAGIPPPPPLPGAGIPPPPPLP 1081

Query: 454  ASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKE 513
             +  P     P  +                        PG  + P        P LP   
Sbjct: 1082 GAGIP----PPPPL------------------------PGAGIPPP-------PPLPG-- 1104

Query: 514  TLLSLPAKDTPPGV---PEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL 570
              + +P     PG    P   L G+ +      P   +P         P P + ++    
Sbjct: 1105 --VGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP---------PPPPLPRVGIPP 1153

Query: 571  EARLSSAAEKEAKPSIGS-LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629
               L  A      P  G+ +PP P L G                    +PP     LP  
Sbjct: 1154 PPPLPGAGIPPPPPLPGAGIPPPPPLPG------------------VGIPPPPP--LPGV 1193

Query: 630  SLQPKAML-GPAI-PPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATS 687
             + P   L G  I PP   P   IPP     P  PP  T  P  PL   SGP  PL    
Sbjct: 1194 GIPPPPPLPGAGIPPPPPLPGMGIPPAPA--PPLPPPGTGIPPPPLLPVSGP--PLLPQV 1249

Query: 688  GPAIASTATT-------LPTTTSQLMAEKDSGPAGQPEKP 720
            G +   T          LP+    L   +D G   QP +P
Sbjct: 1250 GSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEP 1289



 Score = 37.4 bits (85), Expect = 0.086
 Identities = 51/206 (24%), Positives = 68/206 (33%), Gaps = 34/206 (16%)

Query: 160 GSPLPSPPSTAPPPPP--------LLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTP 211
           G+  P+ P TA  P P         LL P      AP  P   +ALS    L       P
Sbjct: 228 GAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEP 287

Query: 212 PDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGR---- 267
            +   P  P        P +PA  P A  SP +     FP  G  +  +   + G     
Sbjct: 288 REPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFP-FPEAGPGEEAAGAPVRGAGDTD 346

Query: 268 ---QAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQ--E 322
              + +A   +P  SP E     +G +                 P R    P +EAQ  +
Sbjct: 347 EEGEEDAFEDAPRGSPGEEWAPEVGED----------------APQRLGEEPEEEAQGPD 390

Query: 323 APRKEEGATKKAPSRLPLPPSFHIRP 348
           AP         APS+    P   I P
Sbjct: 391 APAAASLPGSPAPSQRCFKPYPLITP 416



 Score = 37.4 bits (85), Expect = 0.086
 Identities = 35/116 (30%), Positives = 40/116 (34%), Gaps = 23/116 (19%)

Query: 938  PEPQAPVAWERVAP----SNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993
            P P  P A     P    + +P   PLP +   PP P               IPPPP   
Sbjct: 1043 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG----------IPPPPPLP 1092

Query: 994  NDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAG 1049
                PP P L  +G    PP         LP AG   PP L  +  P      GAG
Sbjct: 1093 GAGIPPPPPLPGVGIPPPPP---------LPGAGIPPPPPLPGAGIPPPPPLPGAG 1139



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 35/117 (29%), Positives = 40/117 (34%), Gaps = 14/117 (11%)

Query: 938  PEPQAPVAWERVAP----SNLPQGHPLPKSFSSPPSP-SNKREEEEEEFNFEVIPPPPEF 992
            P P  P A   + P    + +P   PLP +   PP P                IPPPP  
Sbjct: 955  PPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1014

Query: 993  SNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAG 1049
                 PP P L   G    PP         LP AG   PP L  +  P      GAG
Sbjct: 1015 PGAGIPPPPPLPGAGIPPPPP---------LPGAGIPPPPPLPGAGIPPPPPLPGAG 1062



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 35/116 (30%), Positives = 39/116 (33%), Gaps = 23/116 (19%)

Query: 938  PEPQAPVAWERVAP----SNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993
            P P  P A     P    + +P   PLP +   PP P               IPPPP   
Sbjct: 999  PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG----------IPPPPPLP 1048

Query: 994  NDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAG 1049
                PP P L   G    PP         LP AG   PP L  +  P      GAG
Sbjct: 1049 GAGIPPPPPLPGAGIPPPPP---------LPGAGIPPPPPLPGAGIPPPPPLPGAG 1095



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 29/96 (30%), Positives = 33/96 (34%), Gaps = 19/96 (19%)

Query: 954  LPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPP 1013
            +P   PLP +   PP P               IPPPP       PP P L  +G    PP
Sbjct: 1107 IPPPPPLPGAGIPPPPPLPGAG----------IPPPPPLPGAGIPPPPPLPRVGIPPPPP 1156

Query: 1014 RNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAG 1049
                     LP AG   PP L  +  P      G G
Sbjct: 1157 ---------LPGAGIPPPPPLPGAGIPPPPPLPGVG 1183



 Score = 35.0 bits (79), Expect = 0.43
 Identities = 60/235 (25%), Positives = 84/235 (35%), Gaps = 29/235 (12%)

Query: 370 APASPRLGQSQSQAD---ERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHP 426
           AP SP   Q+ S      E     P  P  PP    LP         AP LP AQ AA  
Sbjct: 263 APGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLP------VSEAPSLPAAQPAA-- 314

Query: 427 PAGFTKTPKSSSPALKPKPNPPS-PENTASSAPVDWRDPSQMEKLRNELAAYLCGSRRED 485
                      SP+    P P + P   A+ APV     +  E   +       GS  E+
Sbjct: 315 ---------KDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEE 365

Query: 486 --RFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAA 543
               +       +  + +E  +GP  P   +L   PA       P   +    +  T   
Sbjct: 366 WAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTT--- 422

Query: 544 PSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGG 598
            +  L S ++ P  SP  S R I+   E  LS  + + A  S+ +   K R +GG
Sbjct: 423 -TRQLSSPNHSPSQSPNQSPR-IKRRPEPSLSRGS-RTALASVAAPAKKHRADGG 474



 Score = 35.0 bits (79), Expect = 0.43
 Identities = 35/117 (29%), Positives = 39/117 (33%), Gaps = 14/117 (11%)

Query: 938  PEPQAPVAWERVAP----SNLPQGHPLPKSFSSPPSP-SNKREEEEEEFNFEVIPPPPEF 992
            P P  P A     P    + +P   PLP +   PP P                IPPPP  
Sbjct: 922  PPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPL 981

Query: 993  SNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAG 1049
                 PP P L   G    PP         LP AG   PP L  +  P      GAG
Sbjct: 982  PGAGIPPPPPLPGAGIPPPPP---------LPGAGIPPPPPLPGAGIPPPPPLPGAG 1029



 Score = 34.7 bits (78), Expect = 0.56
 Identities = 47/179 (26%), Positives = 55/179 (30%), Gaps = 45/179 (25%)

Query: 938  PEPQAPVAWERVAP----SNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993
            P P  P A     P    + +P   PLP+    PP P               IPPPP   
Sbjct: 1120 PPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAG----------IPPPPPLP 1169

Query: 994  NDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLER 1053
                PP P L  +G    PP         LP  G   PP L  +  P      G G    
Sbjct: 1170 GAGIPPPPPLPGVGIPPPPP---------LPGVGIPPPPPLPGAGIPPPPPLPGMG---- 1216

Query: 1054 FSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPP 1112
                             P   P LP  GTG     P    P  G P + +V S+    P
Sbjct: 1217 ---------------IPPAPAPPLPPPGTG---IPPPPLLPVSGPPLLPQVGSSTLPTP 1257



 Score = 33.9 bits (76), Expect = 0.95
 Identities = 48/177 (27%), Positives = 59/177 (33%), Gaps = 36/177 (20%)

Query: 277 PRSP-AEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAP 335
           P SP  E   SAL   PE     PR     P  P     +PV EA   P  +  A K +P
Sbjct: 264 PGSPDTEQALSALSDLPESLAAEPRE----PQQPPSPGGLPVSEAPSLPAAQPAA-KDSP 318

Query: 336 SRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPA-----SPRLGQSQSQADERAGTP 390
           S    P           +P+  P     GE  A AP      +   G+  +  D   G+P
Sbjct: 319 SSTAFP-----------FPEAGP-----GEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSP 362

Query: 391 PP--APPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKP 445
               AP +   AP      P      P  P A       A    +P  S    KP P
Sbjct: 363 GEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAA-------ASLPGSPAPSQRCFKPYP 412



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 33/110 (30%), Positives = 36/110 (32%), Gaps = 13/110 (11%)

Query: 953  NLPQGHPLPKSFSS---------PPSPSNKREEEEEEFNFEVIPPPPEFSNDP--EPPAP 1001
            N+P   PLP + SS         PP P               IP PP         PP P
Sbjct: 854  NIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPP 913

Query: 1002 ALQYLGRQSSPPRNNYS--DLRQLPNAGPGAPPALGFSRFPAGARYAGAG 1049
             L   G    PP        L  LP AG   PP L  +  P      GAG
Sbjct: 914  PLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAG 963


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score =  133 bits (334), Expect = 1e-30
 Identities = 251/1025 (24%), Positives = 344/1025 (33%), Gaps = 218/1025 (21%)

Query: 138  LIPPPPPGPAPGPPQD--ISEPPGGSPLPSPPSTAPPPP---------PLL---LEPPPP 183
            L+PPP   P   PP++   S PP  S L  PP   P  P         PL    L PPP 
Sbjct: 440  LLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPE 499

Query: 184  PSMAPPPP------PVLEA-LSPPH-TLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPA 235
             S   PPP      P+ E+ LSPP  +  SP++ TP   + P P  + L+PP    P   
Sbjct: 500  ESPLSPPPESSPFSPLEESPLSPPEESPPSPALETP---LSPPPEASPLSPPFEESPLSP 556

Query: 236  PP--APASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPE 293
            PP   P SP    +RL PP                 E +  SPP     P+ S + P PE
Sbjct: 557  PPEELPTSPPPEASRLSPP----------------PEESPMSPP-----PEESPMSPPPE 595

Query: 294  PHLTFPRSFKVP--PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS- 350
                FP   + P  PP      S P + ++ +P  E+      P   P+ P   +   S 
Sbjct: 596  ASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSP 655

Query: 351  -QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAG--TPPPAPPLPPPAPPLPPPA 407
              V    +P P+        +P SP   +S +     A   +PPP      P P   P +
Sbjct: 656  LPVVSRLSPPPE-------ESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPAS 708

Query: 408  PPLPPAAPPLPCAQKAAHP-PAGFTKTPKSSSPALKPKPNPP--SPENTASSAPVDWRDP 464
            PP   +   LP  +    P P      P+S  P L P+P  P  SP            +P
Sbjct: 709  PPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEP 768

Query: 465  SQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTP 524
                +        LC    E        GP ++PQ +E    P+  E             
Sbjct: 769  HLSPQPEEPC---LCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHL---------- 815

Query: 525  PGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKP 584
              VPE+        E+  +P    P +      SP P    +  ELE           KP
Sbjct: 816  SPVPEEPCLSPQPEESHLSPQSEEPCL------SPRPEESHLSPELE-----------KP 858

Query: 585  SIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPK 644
             +   P KP  E G+             P  + LP     L P      +  L P +   
Sbjct: 859  PLSPRPEKPPEEPGQC------------PAPEELP-----LFPPPG---EPSLSPLLGEP 898

Query: 645  ATPEPAIPPKATLWPATPPKATLGPA--TPLKATSGPTTPLKATSGPAIASTATTLPTTT 702
            A  EP  PP + L    P +  L P+    L     P  PL     P I + A    +  
Sbjct: 899  ALSEPGEPPLSPL----PEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPL 954

Query: 703  SQLMAEKDSGPAGQPEKP-ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKT-SP 760
             +L     +     PE P A+  + TP     E + ++   +P          PP   SP
Sbjct: 955  GELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPM------ILPPSPGSP 1008

Query: 761  GGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQP- 819
             G   P L +P   Q S           L +        P     PP LP   P+   P 
Sbjct: 1009 VGPASPILMEPLPPQCS----------PLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPI 1058

Query: 820  ------TDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSH 873
                  +DE   H +  E V      AL  +A                S LP  + D S 
Sbjct: 1059 GKVVGVSDEAELHEMETEKVSEPECPALEPSA---------------TSPLPSPMGDLSC 1103

Query: 874  QAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRH 933
             A + + ++    G       +  +      D+P +   P +    L  + +G+ +    
Sbjct: 1104 PAPSPAPALDDFSGLGEDTAPLDGI------DAPGSQPEPGQTPGSLASELKGSPV---- 1153

Query: 934  NWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPP--- 990
                PE  APV    V        +P  K  +   SP     EE+EE    V P PP   
Sbjct: 1154 -LLDPEELAPVTPMEV--------YPECKQTAGQGSPC----EEQEEPRAPVAPTPPTLI 1200

Query: 991  ------EFSN--------------------DPEPPAPALQYLGRQSS-PPRNNYSDLRQL 1023
                  E SN                    DPE        LG  +   P  +   LR  
Sbjct: 1201 KSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLC 1260

Query: 1024 PNAGPGAPPALGFSRFPA--GARYAGAGGLERFSGGGRSLIKKRLYVGEP--HRGPGLPH 1079
             ++ P    +L      A  G +  G  G  R S   RS IK+      P   R  G  H
Sbjct: 1261 TDSLPETDDSLLCDAGTAISGGKAEGEKGRRR-SSPARSRIKQGRSSSFPGRRRPRGGAH 1319

Query: 1080 GGTGR 1084
            GG GR
Sbjct: 1320 GGRGR 1324



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 237/982 (24%), Positives = 327/982 (33%), Gaps = 184/982 (18%)

Query: 101  DDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEP--- 157
            D+ A   +          +   + VGD+        L +  PP   A G P   + P   
Sbjct: 2066 DNRAAHRINKVQKQAESQINKQTKVGDIARKTDRPALHLRIPPQPGALGSPPPAAAPTIF 2125

Query: 158  ------PGG----------SPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPH 201
                  P G           P  S P    P    L  PP  P+  P   P    L+P +
Sbjct: 2126 IGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVPSQDPF--GLAPAY 2183

Query: 202  TLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKS- 260
             L  P  PT P   PP P        PP + A + P    P    T   PPG      S 
Sbjct: 2184 PL-EPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTT--PPGTPRHQPST 2240

Query: 261  -DVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQE 319
             D  L  R       + P SP    G A     EP L+       PPP          ++
Sbjct: 2241 PDPFLKPRCPSLDNLAVPESPGVGGGKA----SEPLLS-------PPPFG------ESRK 2283

Query: 320  AQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQS 379
            A E  ++E GA+  +PS  P    F   P+S  +     E   P   K  AP +PR  Q 
Sbjct: 2284 ALEVKKEELGAS--SPSYGPPNLGFVDSPSSGTHLG-GLELKTPDVFK--APLTPRASQV 2338

Query: 380  QSQADE---RAGTPPPA---PPLPPPAPPL--------PPPAPPLPPAAPPLPCAQKAAH 425
            + Q+     R   PPPA    P PP  P +        P   PPL P   P P     A 
Sbjct: 2339 EPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCAL 2398

Query: 426  PPAGFTKTPKSSSPALKPKPNPPSPENTASS-APVDWRDPSQMEKLRNELAAYLCGSRRE 484
            PP      P S  PA        SP++ +SS +P+  R  S         A   C S   
Sbjct: 2399 PPRSLPSDPFSRVPA--------SPQSQSSSQSPLTPRPLS---------AEAFCPSPVT 2441

Query: 485  DRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEK-------SLG-GSS 536
             RF S  P P   P S+   + P  P     L  P +  PP V  K       SLG G  
Sbjct: 2442 PRFQS--PDPYSRPPSRPQSRDPFAP-----LHKPPRPQPPEVAFKAGSLAHTSLGAGGF 2494

Query: 537  LTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSA-----AEKEAKPSIGSLPP 591
                 A P+  L +   +P   P   VR           S       +   +PS+    P
Sbjct: 2495 PAALPAGPAGELHA--KVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVP 2552

Query: 592  KPRLEGGR-ICENGADDDKLSKP-------VAKNLPPQSTTLLPTTSLQPKAM-LGPAIP 642
            +P L     I  +      L KP          N  P  + L P++    ++  L P  P
Sbjct: 2553 QPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRP 2612

Query: 643  PKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTT 702
            P   P PA  P  +L     P  + G +      SG T+P++    P    T       T
Sbjct: 2613 PSVLPPPA--PDGSL-----PYLSHGAS----QRSGITSPVEKREDP---GTGMGSSLAT 2658

Query: 703  SQLMAEKDSGPAG--------QPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAF 754
            ++L   +D G +G        Q ++   +E+    Q +      E     T  A + A  
Sbjct: 2659 AELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEK---ETAAAAAGAVG 2715

Query: 755  PP------KTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPG---EPVEVKE 805
            PP       +SP   ++     P       S  V  + P+   G   GPG       +  
Sbjct: 2716 PPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVG-LPPSKLSGPILGPGSFPSDDRLSR 2774

Query: 806  PPGLPAKPPASAQPTDELLRHPVTG-EVVERGSPMALLLAARQRAQKGRSVGAALGRSSL 864
            PP     PPA+    D   R  V G +   + +P    L  +Q+ Q+             
Sbjct: 2775 PP-----PPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQ------------- 2816

Query: 865  PGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPL---TTEIPNKWGPRLG 921
               L        A+S     S   P+  T  P+L ++A   SPL   +T +P    P  G
Sbjct: 2817 ---LWQQQQATAATSMRFAMSARFPS--TPGPELGRQA-LGSPLAGISTRLPGPGEPVPG 2870

Query: 922  RDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEF 981
                   +  RHN  K        +    P   P+ +P+ +       P     E     
Sbjct: 2871 PAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRFYPVSE------DPHRLAPEGLRGL 2924

Query: 982  NFEVIPPPPEFSNDPEPPAPAL 1003
                +PP         PPAP L
Sbjct: 2925 AVSGLPP----QKPSAPPAPEL 2942



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 123/451 (27%), Positives = 168/451 (37%), Gaps = 102/451 (22%)

Query: 130  PGQYG--QDLLIPPPPPGPAPGP---PQDISEP--PGGSPLP-----SP---PSTAP--- 171
            PGQ    ++L + PPP  P+  P      +SEP  P  SPLP     SP   PS +P   
Sbjct: 871  PGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLM 930

Query: 172  PPPPLLLEPPPPPSMAPPPPPVLEAL-------------SPPHTLSSPSIPTPPDFIPPA 218
            PP PL   PP  P +    PP L  L              P   L++P + TP   I P 
Sbjct: 931  PPDPL--PPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETP---ISP- 984

Query: 219  PPLAFLAPPPPPVPAPAPPAPASPHTVGTRL----FPPGGVTKWKSDVALNGRQAEATRA 274
            PP A    P P  P   PP+P SP    + +     PP      +   +L  + +  ++ 
Sbjct: 985  PPEANCTDPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSPLLQH--SLVPQNSPPSQC 1042

Query: 275  SPPR------SPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEE 328
            SPP       SP  P G  +G + E  L    + KV  P              E P  E 
Sbjct: 1043 SPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEP--------------ECPALEP 1088

Query: 329  GATKKAPSRL-----PLP-PSFHIRPASQVYPDRAPEP--DCPGELKATAPASPRLGQSQ 380
             AT   PS +     P P P+  +   S +  D AP    D PG       + P  GQ+ 
Sbjct: 1089 SATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPG-------SQPEPGQTP 1141

Query: 381  -SQADERAGTPPPAPP--LPPPAP---------------PLPPPAPPLPPAAPPLPCAQK 422
             S A E  G+P    P  L P  P               P      P  P AP  P   K
Sbjct: 1142 GSLASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTPPTLIK 1201

Query: 423  A--AHPPAGFTKTPKSSS-PALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLC 479
            +   +  +  ++   S+S P  +P    P PE    S  ++    + +   R+E +  LC
Sbjct: 1202 SDIVNEISNLSQGDASASFPGSEPLLGSPDPEG-GGSLSMELGVSTDVSPARDEGSLRLC 1260

Query: 480  GSR--REDRFLSHRPGPTVAPQSKEGKKGPR 508
                   D  L    G  ++    EG+KG R
Sbjct: 1261 TDSLPETDDSLLCDAGTAISGGKAEGEKGRR 1291



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 118/499 (23%), Positives = 167/499 (33%), Gaps = 104/499 (20%)

Query: 64   SGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYS 123
            S    L+    VR     L    QE   L +  P++  +F+     G+   VNG  +L  
Sbjct: 4534 SSRKKLRKEDGVRASEALLKQLKQELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRG 4593

Query: 124  SVGD----LRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLE 179
            + G       P  Y Q L               ++S PP      +PPS+ PP PP  ++
Sbjct: 4594 AFGSGALPTGPDYYSQLLT------------KNNLSNPP------TPPSSLPPTPPPSVQ 4635

Query: 180  PP------PPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIP--PAPP------LAFLA 225
                    P   +   P     A      L   S     D +   P PP      +   +
Sbjct: 4636 QKMVNGVTPSEELGEHPKDAASARDSERALRDTSEVKSLDLLAALPTPPHNQTEDVRMES 4695

Query: 226  PPPPPVPAPAPPAPASPHTVGTRL--FPPGGVTKWKS-DVALNGRQAEATRASPPRSPAE 282
                  P    PA +    +G     FP  G  +W+  D AL+       RAS P  P  
Sbjct: 4696 DEDSDSPDSIVPASSPESILGEEAPRFPHLGSGRWEQEDRALSPVIPLIPRASIPVFPDT 4755

Query: 283  PKGSALG---PNPEPHLTFPR-------------------------------SFKVP--- 305
                ALG   P   P  T+ +                               S K+P   
Sbjct: 4756 KPYGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSY 4815

Query: 306  ----PPTPVRTSSIPVQEAQEAPR-KEEGATKKAPSRLP--------LPPSFHIRPASQV 352
                P +P R  + P +   E P  KE+G   K+P   P        + P + ++    +
Sbjct: 4816 EVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDI 4875

Query: 353  YP---DRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPP 409
                   +P P+ P +   T   S  L   Q  A      PPP  P PPP+P  P PA P
Sbjct: 4876 LSLLKQESPAPEPPTQHSYTYNVS-NLDVRQLSA------PPPEEPSPPPSPLAPSPASP 4928

Query: 410  LPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAP---VDWRDPSQ 466
                   LP  +  A PP        SS  + +PKP    PE    S P     W+   +
Sbjct: 4929 PTEPLVELP-TEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLKKWKG-VR 4986

Query: 467  MEKLRNELAAYLCGSRRED 485
             ++LR  L       R+ED
Sbjct: 4987 WKRLRLLLTIQKGSGRQED 5005



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 167/769 (21%), Positives = 247/769 (32%), Gaps = 98/769 (12%)

Query: 144  PGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTL 203
            PGP  GP Q++    G  P P  P   P PP  L   P    + P PPP           
Sbjct: 4267 PGPQTGPLQEL----GAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPP----------- 4311

Query: 204  SSPSIPTPPDFIP-PAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDV 262
            SSP  P  P  +P P+  L   A  PP    P  P P  P    T   PPG V+   + +
Sbjct: 4312 SSPQEPKRPSQLPSPSSQLPTEAQLPP--THPGTPKPQGP----TLEPPPGRVSPAAAQL 4365

Query: 263  ALNGRQAEATRASPPRSPAE---PKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQE 319
            A            PP + AE   P+ S+L P    HL       VP  + +     P +E
Sbjct: 4366 ADTLFSKGLGPWDPPDNLAETQKPEQSSLVPG---HLDQVNGQVVPEASQLSIKQEPREE 4422

Query: 320  -----AQEAPRKEEGATKKAPSRL-------PLPPSFHIRPASQVYPDRAPEPDCPGELK 367
                 AQ   R+  G    AP          P   + H+     +           G   
Sbjct: 4423 PCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEG 4482

Query: 368  ATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPP 427
              A  +  +    +  +++    P          PL P    +  A+  L  ++K     
Sbjct: 4483 LRAEINGHIDSKLAGLEQKLQGTPSNKEDAAARKPLTPKPKRVQKASDRLVSSRKKLRKE 4542

Query: 428  AGFTKTPK-----SSSPALKPKPNPPSPENTASSAPVDWRDP-SQMEKLRNEL--AAYLC 479
             G   +           +L P   P    N +  AP     P +   +LR      A   
Sbjct: 4543 DGVRASEALLKQLKQELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPT 4602

Query: 480  GSRREDRFL--SHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDT---PPGVPEKSLGG 534
            G     + L  ++   P   P S      P + +K      P+++    P          
Sbjct: 4603 GPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSE 4662

Query: 535  SSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSI-GSLPPK- 592
             +L +T    SL L +    P  + T  VR   +E      S     +  SI G   P+ 
Sbjct: 4663 RALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRF 4722

Query: 593  PRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIP 652
            P L  GR       +D+   PV   +P  S  + P T  +P   LG  +P K        
Sbjct: 4723 PHLGSGR----WEQEDRALSPVIPLIPRASIPVFPDT--KPYGALGLEVPGKL------- 4769

Query: 653  PKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEK--D 710
                            P T  +   G    +  T   A A     +    ++L++ K  +
Sbjct: 4770 ----------------PVTTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPN 4813

Query: 711  SGPAGQPEKPASQEVSTPSQARGEGSPSEATRL--------PTQGARSSAAFPPKTSPGG 762
            S     PE PA +  + P +   EG   +   L        P    +  A  P  T    
Sbjct: 4814 SYEVLFPESPA-RAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQ 4872

Query: 763  GEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDE 822
             ++  L K          + +                P E   PP  P  P  ++ PT+ 
Sbjct: 4873 LDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEP 4932

Query: 823  LLRHPVTGEVVERGSPMALLLAARQRA--QKGRSVGAALGRSSLPGSLR 869
            L+  P T  + E   P  L LA+   +   K R+     G  S P  L+
Sbjct: 4933 LVELP-TEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLK 4980



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 212/933 (22%), Positives = 289/933 (30%), Gaps = 181/933 (19%)

Query: 195  EALSPPHTLSSPSIP--------TPPDFIPPAP----PLAFLAPPPPPVPAPAP------ 236
            EA S PH L+ PS+         T     P  P    P+     P PP P P        
Sbjct: 4126 EASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGL 4185

Query: 237  PAPASPHTVGTRLFPPGGVT-------------KWKSDVALNGRQAEATRASPPRSPAEP 283
            P      TVG       GV              + +    L  RQ + ++A     P + 
Sbjct: 4186 PGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQE 4245

Query: 284  KGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP- 342
             G+   P        P+    P P      + P+QE    PR +       P RLP PP 
Sbjct: 4246 PGTQTSPLQGLLGCQPQLGGFPGP-----QTGPLQELGAGPRPQ------GPPRLPAPPG 4294

Query: 343  SFHIRPA-SQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPP-A 400
            +    P    V+P   P P  P E K  +    +L    SQ    A  PP  P  P P  
Sbjct: 4295 ALSTGPVLGPVHP--TPPPSSPQEPKRPS----QLPSPSSQLPTEAQLPPTHPGTPKPQG 4348

Query: 401  PPLPPPAPPLPPAAPPLPCAQKAA-----HPPAGFTKTPKSSSPALKPK----------- 444
            P L PP   + PAA  L     +       PP    +T K    +L P            
Sbjct: 4349 PTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVPGHLDQVNGQVVP 4408

Query: 445  -------PNPPSPENTASSAPVDWRD----PSQMEKLRNELAAYLCGSRREDRFLSHRP- 492
                      P  E  A  A    R+    P       N L   L G R E   L  +  
Sbjct: 4409 EASQLSIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLL--LAGPRSEAGHLLLQKL 4466

Query: 493  --GPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPS 550
                 V   +  G +G R      + S  A     G+ +K  G  S  E  AA     P 
Sbjct: 4467 LRAKNVQLSTGRGSEGLRAEINGHIDSKLA-----GLEQKLQGTPSNKEDAAARKPLTPK 4521

Query: 551  VDYIPQ--DSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDD 608
               + +  D    S +++R E   R S A  K+ K  +  LP    L    I  N +   
Sbjct: 4522 PKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLP----LTEPAITANFS--- 4574

Query: 609  KLSKPVAKNLPPQSTTLLPTTSLQPKAMLGP-----AIPPKATPEPAIPPKATLWPATPP 663
             L  P     P    + L           GP      +       P  PP +   P TPP
Sbjct: 4575 -LFAPFGSGCPVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSL--PPTPP 4631

Query: 664  KATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQ 723
                 P+   K  +G T   +    P  A++A             K          P   
Sbjct: 4632 -----PSVQQKMVNGVTPSEELGEHPKDAASARDSERALRDTSEVKSLDLLAALPTPPHN 4686

Query: 724  EVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSRE-- 781
            +         E S S  + +P     S           G E P    PH       +E  
Sbjct: 4687 QTEDVRMESDEDSDSPDSIVPASSPESIL---------GEEAPRF--PHLGSGRWEQEDR 4735

Query: 782  -VAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840
             ++ V+P + R               P  P   P  A   +   + PVT     +GS ++
Sbjct: 4736 ALSPVIPLIPRASI------------PVFPDTKPYGALGLEVPGKLPVTTWEKGKGSEVS 4783

Query: 841  LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVV-PKLP 899
            ++L     A K  + G  +  + L                    S   PNS+ V+ P+ P
Sbjct: 4784 VMLTVSAAAAKNLN-GVMVAVAELL-------------------SMKIPNSYEVLFPESP 4823

Query: 900  KEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGH- 958
              A  + P   E     G   G   EG       +W K        ++ V P    +   
Sbjct: 4824 ARAGTE-PKKGEAEGPGGKEKG--LEGKSPDTGPDWLKQ-------FDAVLPGYTLKSQL 4873

Query: 959  ---PLPKSFSSPPSPSNKREEEEEEFNFEV----IPPPPEFSNDPEPPAPALQYLGRQSS 1011
                L K  S  P P  +        N +V     PPP E S  P P AP+       +S
Sbjct: 4874 DILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPS------PAS 4927

Query: 1012 PPRNNYSDLRQLPNAGPGAPPALGFSRFPAGAR 1044
            PP     +L   P A P  P  L  +  P  AR
Sbjct: 4928 PPTEPLVELPTEPLAEPPVPSPLPLASSPESAR 4960



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 172/778 (22%), Positives = 253/778 (32%), Gaps = 149/778 (19%)

Query: 481  SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETL------LSLPAKDTPPGVPEKSLGG 534
            SR    F S  PG   +P +  G   P  P   T       LS   +       ++ LG 
Sbjct: 1955 SRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQ 2014

Query: 535  SSLTETEAAPSLTLPSV--DYIPQDSPTPSVRQIRNELEAR-----LSSAAEKEAKPSIG 587
             S        ++  P++  DY    S    + ++  ++ A      L  A +  A   I 
Sbjct: 2015 LSTISPVLYANINFPNLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRIN 2074

Query: 588  SLPPKPRLEGGRICENGADDDKLSKPVAK-NLPPQSTTL-LPTTSLQPKAMLGPAIPPKA 645
             +  +   +  +  + G    K  +P     +PPQ   L  P  +  P   +G    P  
Sbjct: 2075 KVQKQAESQINKQTKVGDIARKTDRPALHLRIPPQPGALGSPPPAAAPTIFIGSPTTPAG 2134

Query: 646  TPEPAI----PPKATL-WPATPPKA--TLGPATPLKATS------GPTTPLKATSGPAIA 692
                A     PP  ++  P +P +    L P  P +  S       P  PL+    P   
Sbjct: 2135 LSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAPAYPLE----PRFP 2190

Query: 693  STATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSA 752
            +   T P   S         P G P +P     S+     G G P E    P    R   
Sbjct: 2191 TAPPTYPPYPS---------PTGAPAQPPMLGASSRP---GAGQPGEFHTTPPGTPRHQP 2238

Query: 753  AFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAK 812
            + P              KP C             P+L         + + V E PG+   
Sbjct: 2239 STPDP----------FLKPRC-------------PSL---------DNLAVPESPGV--- 2263

Query: 813  PPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAA-LGRSSLPGSLRDH 871
                 + ++ LL  P  GE     S  AL +   +      S G   LG    P S   H
Sbjct: 2264 --GGGKASEPLLSPPPFGE-----SRKALEVKKEELGASSPSYGPPNLGFVDSPSS-GTH 2315

Query: 872  SHQAEASSDSIFHSQGTPNSFTVVPKLP------KEAEKDSPLTTEIPNKWGPRLGRDAE 925
                E  +  +F +  TP +  V P+ P      +E      L    P+   P + R   
Sbjct: 2316 LGGLELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSH--PDIFRPGS 2373

Query: 926  GTELSRRHNWT-KPEPQAPVAWERVAPSNLPQGH-----PLPKSFSSPPSPSNKREEEEE 979
             T+   +   T +P+P  P +   + P +LP          P+S SS  SP   R    E
Sbjct: 2374 YTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAE 2433

Query: 980  EFNFEVIPP----PPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALG 1035
             F    + P    P  +S  P  P     +      PPR    ++     AG  A  +LG
Sbjct: 2434 AFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHK-PPRPQPPEVAF--KAGSLAHTSLG 2490

Query: 1036 FSRFPAGARYAGAGGLERF--SGGGRSLIKKR-----------------LYVGEPHRGPG 1076
               FPA      AG L     SG   + ++                     VGEP   P 
Sbjct: 2491 AGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPP 2550

Query: 1077 LPHGGTGRSLSSPNCFGPQP--GGPEMRR--VNSAGRAPPGGLHAPRLSLEGAARGAAEA 1132
            +P  G        + FGP P  G P+     V +    P G    P     G + G +  
Sbjct: 2551 VPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPL 2610

Query: 1133 KHKA-------PGSADYGFAPAAGRSPYTT---------TRYGSPINTFTVRPGTRHP 1174
            +  +        GS  Y    A+ RS  T+         T  GS + T  + PGT+ P
Sbjct: 2611 RPPSVLPPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAEL-PGTQDP 2667



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 101/438 (23%), Positives = 152/438 (34%), Gaps = 63/438 (14%)

Query: 621  QSTTLL-PTTSLQPKAMLGPAIPPKATPEPAIPPK--ATLWPATPPKATLGPATPLKATS 677
            QS TLL P    Q +  LGP +P K     + P     TL      + T+ PA   +AT 
Sbjct: 3980 QSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATE 4039

Query: 678  GPTTPLKATSGP-AIASTATTLPTTTSQLMAEKDSG-------PAGQPEKPASQEVSTPS 729
            GP+T      GP AI +T  ++ T   ++              P  QP+ P+S ++  P 
Sbjct: 4040 GPST---HQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQ-PSSLQLQPPL 4095

Query: 730  QARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTL 789
            +  G+    + + L T G  S       +S     VP L      Q S+S       P  
Sbjct: 4096 RLPGQ-QQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLA----QPSVS---LGDQPGS 4147

Query: 790  ARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRA 849
                  GP +P+  +     P +     QP       P  G V++ G  +  +       
Sbjct: 4148 MTQNLLGPQQPMLER-----PMQNNTGPQP-------PKPGPVLQSGQGLPGVGIMPTVG 4195

Query: 850  QKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTV--VPKLPKEAEKDSP 907
            Q    +   L ++     LR  S Q +    ++   +    S  V   P   +   + SP
Sbjct: 4196 QLRAQLQGVLAKNP---QLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSP 4252

Query: 908  LTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWER-------------VAPSNL 954
            L   +  +  P+LG          +     P PQ P                  V P+  
Sbjct: 4253 LQGLLGCQ--PQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPP 4310

Query: 955  PQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPR 1014
            P     PK  S  PSPS++   E +         PP     P+P  P L+    + SP  
Sbjct: 4311 PSSPQEPKRPSQLPSPSSQLPTEAQ--------LPPTHPGTPKPQGPTLEPPPGRVSPAA 4362

Query: 1015 NNYSDLRQLPNAGPGAPP 1032
               +D       GP  PP
Sbjct: 4363 AQLADTLFSKGLGPWDPP 4380



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 45/145 (31%), Positives = 57/145 (39%), Gaps = 12/145 (8%)

Query: 161  SPLPSPPS------TAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDF 214
            SP P PP+               L  PPP   +PPP P+  + + P T     +PT P  
Sbjct: 4883 SPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLA 4942

Query: 215  IPPAP-PLAFLAPPPPPVPAP-APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEAT 272
             PP P PL   + P    P P A P      +   RL    GV +WK    L   Q  + 
Sbjct: 4943 EPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLKKWKGV-RWKRLRLLLTIQKGSG 5001

Query: 273  RASPPRSPA---EPKGSALGPNPEP 294
            R    R  A   E  G+AL P+  P
Sbjct: 5002 RQEDEREVAEFMEQLGTALRPDKVP 5026



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 99/457 (21%), Positives = 139/457 (30%), Gaps = 102/457 (22%)

Query: 130  PGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAP-----PPPPLLLEPPPPP 184
            PG      ++ P  P P P  PQ   EP   S LPSP S  P     PP       P  P
Sbjct: 4293 PGALSTGPVLGPVHPTPPPSSPQ---EPKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQGP 4349

Query: 185  SMAPPPPPVLEALS---------------PPHTLSSPSIPTPPDFIP-----------PA 218
            ++ PPP  V  A +               PP  L+    P     +P           P 
Sbjct: 4350 TLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVPGHLDQVNGQVVPE 4409

Query: 219  PPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPG--------------------GVTKW 258
                 +   P   P             G  +  PG                     + + 
Sbjct: 4410 ASQLSIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRA 4469

Query: 259  KSDVALNGRQAEATRA------SPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRT 312
            K+     GR +E  RA          +  E K      N E      R    P P  V+ 
Sbjct: 4470 KNVQLSTGRGSEGLRAEINGHIDSKLAGLEQKLQGTPSNKED--AAARKPLTPKPKRVQK 4527

Query: 313  SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAP- 371
            +S  +  +++  RKE+G          L     + P +        EP         AP 
Sbjct: 4528 ASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPLT--------EPAITANFSLFAPF 4579

Query: 372  --ASPRLGQSQSQADERAGTPPPA---------------PPLPPPA-PPLPPPAPPLPPA 413
                P  GQSQ +    +G  P                 PP PP + PP PPP+      
Sbjct: 4580 GSGCPVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMV 4639

Query: 414  APPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNE 473
                P  +   HP      + + S  AL+      S +  A+   +     +Q E +R E
Sbjct: 4640 NGVTPSEELGEHPKD--AASARDSERALRDTSEVKSLDLLAA---LPTPPHNQTEDVRME 4694

Query: 474  LAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLP 510
                      ED        P  +P+S  G++ PR P
Sbjct: 4695 --------SDEDSDSPDSIVPASSPESILGEEAPRFP 4723



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 44/198 (22%), Positives = 68/198 (34%), Gaps = 40/198 (20%)

Query: 273  RASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATK 332
            R S P  PA P  S++  N    +   ++F    P P    S+P+Q+ Q+   +++ AT 
Sbjct: 2771 RLSRPPPPATP--SSMDVNSRQLVGGSQAFYQRAPYP---GSLPLQQQQQQLWQQQQATA 2825

Query: 333  KAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQS------QSQADER 386
                R  +   F   P  ++       P      +   P  P  G +      + + + +
Sbjct: 2826 ATSMRFAMSARFPSTPGPELGRQALGSPLAGISTRLPGPGEPVPGPAGPAQFIELRHNVQ 2885

Query: 387  AGTPPPAPPLPPPAPPLPPP-----------------------APPLPPAAPPLPCAQKA 423
             G  P   P P   PP  P                         PP  P+APP P    +
Sbjct: 2886 KGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNS 2945

Query: 424  AHPPAGFTKTPKSSSPAL 441
             HP      TP +  P L
Sbjct: 2946 LHP------TPHTKGPTL 2957



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 136/636 (21%), Positives = 211/636 (33%), Gaps = 121/636 (19%)

Query: 427  PAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDR 486
            P     TP+S   A +P    PS    +    V  +   Q   L+ +    L G +++  
Sbjct: 4048 PLAIGTTPESM--ATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQV 4105

Query: 487  FLSHRPGPTVAPQSKEGK--KGPRLPEKETLLSLPAKDTPPGVPEKSLGG---------- 534
             L H  G     Q   G   +   +P      S+   D P  + +  LG           
Sbjct: 4106 SLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQ 4165

Query: 535  SSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPR 594
            ++       P   L S   +P     P+V Q+R +L+  L+        P +  L P+ +
Sbjct: 4166 NNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAK------NPQLRHLSPQQQ 4219

Query: 595  LEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQ------------PKAMLGPAIP 642
             +   +               +  PP       T+ LQ            P    GP   
Sbjct: 4220 QQLQALL---MQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQE 4276

Query: 643  PKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTT 702
              A P P  PP+    PA P   + GP        GP  P    S P      + LP+ +
Sbjct: 4277 LGAGPRPQGPPRL---PAPPGALSTGPVL------GPVHPTPPPSSPQEPKRPSQLPSPS 4327

Query: 703  SQLMAE-----------KDSGPAGQPE----KPASQEVSTPSQARGEGSPSEATRL-PTQ 746
            SQL  E           K  GP  +P      PA+ +++    ++G G       L  TQ
Sbjct: 4328 SQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQ 4387

Query: 747  GARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEP 806
                S+  P       G+V     P   Q S+ +E         R      G     +E 
Sbjct: 4388 KPEQSSLVPGHLDQVNGQV----VPEASQLSIKQE--------PREEPCALGAQSVKREA 4435

Query: 807  PGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSS--L 864
             G P   P ++     LL  P       R     LLL   Q+  + ++V  + GR S  L
Sbjct: 4436 NGEPIGAPGTSNHL--LLAGP-------RSEAGHLLL---QKLLRAKNVQLSTGRGSEGL 4483

Query: 865  PGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDA 924
               +  H     A  +     QGTP++        ++A    PLT +      P+  + A
Sbjct: 4484 RAEINGHIDSKLAGLEQ--KLQGTPSN-------KEDAAARKPLTPK------PKRVQKA 4528

Query: 925  EGTELSRRHNWTKPE----PQAPVAWERVAPSNLPQGHP-LPKSFS-----SPPSPSNKR 974
                +S R    K +     +A +   +   S LP   P +  +FS         P N +
Sbjct: 4529 SDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPLTEPAITANFSLFAPFGSGCPVNGQ 4588

Query: 975  EEEEEEFNFEVIPPPPEF----------SNDPEPPA 1000
             +    F    +P  P++          SN P PP+
Sbjct: 4589 SQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPS 4624



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 36/114 (31%), Positives = 45/114 (39%), Gaps = 28/114 (24%)

Query: 142  PPPGPAPGPPQDISEP--------PGGSPLPSP-PSTAPPPPPLLLEP------------ 180
            P PGPA GP Q I           PGG+P P   P   P   P+  +P            
Sbjct: 2867 PVPGPA-GPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLA 2925

Query: 181  ----PPPPSMAPPPPPVLEALSP-PHTLSSPSIPTPPDFIPPAPPLAFLAPPPP 229
                PP    APP P +  +L P PHT   P++PT  + +   P    L  P P
Sbjct: 2926 VSGLPPQKPSAPPAPELNNSLHPTPHT-KGPTLPTGLELVNRPPSSTELGRPNP 2978



 Score = 31.6 bits (70), Expect = 4.7
 Identities = 82/323 (25%), Positives = 103/323 (31%), Gaps = 71/323 (21%)

Query: 173  PPPLLLEPPPPPSMAPPPPPVLEALSP--PHTLSSPSIPTPPDFIPPAPPLAFLAPPPPP 230
            P PL  E  PPP+     P +   L    P        P+P  F           P   P
Sbjct: 3091 PGPLGPEERPPPAADASEPRLASVLPEVKPKVEEGGRHPSPCQF-------TIATPKVEP 3143

Query: 231  VPA---------PAPPAPASPHT-VGTRLFPPGGVTKWKSDV-ALNGRQAEATRASPPRS 279
             PA         P      S  T +GT  F   G T  K+   A  G  A     SP   
Sbjct: 3144 APAANSLGLGLKPGQSMMGSRDTRMGTGPFSSSGHTAEKASFGATGGPPAHLLTPSPLSG 3203

Query: 280  PAEPKGSALGPNPEPH---LTFP-------------RSFKVPPPTPVRTSSIPVQEAQEA 323
            P    GS+L    E     LT P              S  V    P+    +   E +E 
Sbjct: 3204 PG---GSSLLEKFELESGALTLPGGPAASGDELDKMESSLVASELPLLIEDLLEHEKKEL 3260

Query: 324  PRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP--DCPGELKATA----PASPRLG 377
             +K++              S  ++PA Q    +        PG  +A +     +SP L 
Sbjct: 3261 QKKQQ-------------LSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHEGSSPSLA 3307

Query: 378  QSQSQAD-ERAGTPPPAPPLPPPAPPLPPPAPPLPP-AAPPLPCAQKAAHPPAG------ 429
             SQ Q     AG   P   LP P  P  PPA  L    AP +       H  +G      
Sbjct: 3308 GSQQQLSLGLAGARQPG--LPQPLMPTQPPAHALQQRLAPSMAMVSNQGHMLSGQHGGQA 3365

Query: 430  FTKTPKSSSPALKPKP---NPPS 449
                 +SS P L  KP    PPS
Sbjct: 3366 GLVPQQSSQPVLSQKPMGTMPPS 3388


>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
          Length = 1682

 Score =  124 bits (312), Expect = 4e-28
 Identities = 235/991 (23%), Positives = 330/991 (33%), Gaps = 208/991 (20%)

Query: 138  LIPPPPPGPAPGPPQDISEPPGGSPLPS--------PPSTAPPPPPLLLEPPPPPSMAPP 189
            ++ P PP    GP  +    PGG             PP    PPPPL   PPPPP   PP
Sbjct: 205  VVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPLPPPPL--PPPPPPPPPPP 262

Query: 190  PPPVLEALSPPHTLSSP----------------------------SIPTPPDFIPPA--- 218
            PP    A SPP  L+ P                            S+P P  +  PA   
Sbjct: 263  PPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPHPYPYPAPAYTA 322

Query: 219  -PPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGG------VTKWKSDVALNGRQAEA 271
             PP   L P  PP P P PP  A  H       PPG       V + + D +++     A
Sbjct: 323  HPPGHRLVPAAPPGPGPRPPG-AESHGCLPATRPPGSDLRESRVQRSRMDSSVS---PAA 378

Query: 272  TRASPPRSPAEPKG---------SALGPNP-----EPHLTFPRSFKVPPPTPVRTSSIPV 317
            T A  P +P+ P G         S+   N      EP+   P +     P    +    +
Sbjct: 379  TTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRL 438

Query: 318  QEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLG 377
              +  + RK       A   L LPP           P   P P CP  L+   P +   G
Sbjct: 439  GPSAHSSRKPFLGAPAATPHLSLPPG----------PSSPPPPPCPRLLRPPPPPAWLKG 488

Query: 378  QSQSQADERA--------GTPPPAPPLPPPAPP----LPPPAPPL--------PPAAPPL 417
             +   A E          GT  P  P PPP P     L PPA            P  PP 
Sbjct: 489  PACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPT 548

Query: 418  PCAQKA-------AHPPAGFTKTPKSS--SPALKPKPNPPSPENTASSAPVDWRDPSQME 468
            P    +       +  PAG    P     + ++ P P PPSP       P+     +   
Sbjct: 549  PTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPP 608

Query: 469  KLRNELAAYLCGSRREDRFLSHRPGPTVA-PQSKEGKKGPRLPEKETLLSLPAKDTPPGV 527
               +       GS R        P P V+ P++ E   GP        LS   +  PPGV
Sbjct: 609  APPSSCHQNTSGSFRR----PESPRPRVSFPKTPEVGPGP----PPGPLSKAPQPVPPGV 660

Query: 528  PEKSLGGSSLTETEAAP---SLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKP 584
             E    G  L +    P       P+   I  D     ++ +   +        E++ + 
Sbjct: 661  GELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKE-----EEQQQH 715

Query: 585  SIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSL---QPKAMLGPAI 641
              G  P  P  E     ++    D      A  +   +TT   TT+    + +    PA+
Sbjct: 716  EAGVAPQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPAL 775

Query: 642  PPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLK---ATSGPAIASTATTL 698
            PP   P    PP +   P  PP     PA+ LK+ +      K     +G A+++    L
Sbjct: 776  PP-PPPLAKFPPPSQ--PQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPL 832

Query: 699  PTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQG---ARSSAA-- 753
            PTT  Q      SG    P   A+      +Q   + S S +++  T G   AR   A  
Sbjct: 833  PTT--QYSPGPPSGATALPPTSAAPS----AQGSPQPSASSSSQFSTSGGPWARERRAGE 886

Query: 754  --FPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLAR---GGAAGPGEPVEVKEPPG 808
               P   +P     P    P   +S +  E++    TL       A  P +PV+  EP  
Sbjct: 887  EPVPGPMTPTQPPPPLSLPPARSESEVLEEISRACETLVERVGRSATDPADPVDTAEPAD 946

Query: 809  LPAK---PPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLP 865
               +   PPA A+               E    +A +  + +R QK              
Sbjct: 947  SGTERLLPPAQAK---------------EEAGGVAAVSGSCKRRQKEHQ----------- 980

Query: 866  GSLRDHSHQAEASSDSIFH--SQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRD 923
               ++H     A  DS+     +G   +   VPK     EK   +   +  +     GR+
Sbjct: 981  ---KEHRRHRRACKDSVGRRPREGRAKAKAKVPK-----EKSRRVLGNLDLQSEEIQGRE 1032

Query: 924  AEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNF 983
                +L       KP P AP           P   P P +  +PPS S   ++  EE   
Sbjct: 1033 KSRPDLGGASK-AKP-PTAPA----------PPSAPAPSAQPTPPSASVPGKKAREE--- 1077

Query: 984  EVIPPPPEFSNDPEPPAPALQYLGRQSSPPR 1014
               P PP  S      A  L+       PP+
Sbjct: 1078 --APGPPGVSR-----ADMLKLRSLSEGPPK 1101



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 87/360 (24%), Positives = 122/360 (33%), Gaps = 42/360 (11%)

Query: 60   TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119
            T + + TAT +   +  P L   P  A+         P  P       +   +S++ G  
Sbjct: 756  TTTTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQK 815

Query: 120  RLYSSVG---DLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTA------ 170
              Y   G     RPG        P PP G    PP   +    GSP PS  S++      
Sbjct: 816  YCYRGTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSAAPSAQGSPQPSASSSSQFSTSG 875

Query: 171  ------------PPPPPLLLEPPPPPSMAPP---PPPVLEALSPP-HTLSSPSIPTPPDF 214
                        P P P+    PPPP   PP      VLE +S    TL      +  D 
Sbjct: 876  GPWARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEISRACETLVERVGRSATD- 934

Query: 215  IPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRA 274
              PA P+    P         PPA A     G          + K     + R   A + 
Sbjct: 935  --PADPVDTAEPADSGTERLLPPAQAKEEAGGVAAVSGSCKRRQKEHQKEHRRHRRACKD 992

Query: 275  SPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKE-EGATKK 333
            S  R P E +  A    P+      +S +V     +++  I   + +E  R +  GA+K 
Sbjct: 993  SVGRRPREGRAKAKAKVPK-----EKSRRVLGNLDLQSEEI---QGREKSRPDLGGASKA 1044

Query: 334  APSRLPLPPSFHIRPASQVYPDRAPEPDCPG-ELKATAPASPRLGQSQSQADERAGTPPP 392
             P   P PPS    PA    P   P    PG + +  AP  P + ++           PP
Sbjct: 1045 KPPTAPAPPS---APAPSAQP-TPPSASVPGKKAREEAPGPPGVSRADMLKLRSLSEGPP 1100


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score =  122 bits (306), Expect = 2e-27
 Identities = 155/617 (25%), Positives = 225/617 (36%), Gaps = 122/617 (19%)

Query: 182  PPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPAS 241
            P  S+ PP  P  + ++P +T S PS P PP   PP PP     PPPPP+P+ + P+  S
Sbjct: 601  PYTSLVPPLSPQPKIVTP-YTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGS 659

Query: 242  PHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRS 301
               +  +      +T+ +     N  Q       PP  P     S      +P +  P +
Sbjct: 660  AAPMFVKY---STITRLQ-----NASQHSGALFKPPTPPVMQSQSV-----KPQILVPPN 706

Query: 302  FKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVY----PDRA 357
              VPPP P      P   +  A  K        P     PP   I     +     P   
Sbjct: 707  GVVPPPPP--PPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPP 764

Query: 358  PEPDCPGELKATAPASPRL-------GQSQSQADERAGTPPPAPPLPP----PAPPLP-- 404
            P P  P  L   AP  P +        ++ +    +A  P P PP+PP    PA P    
Sbjct: 765  PPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYI 824

Query: 405  PPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDP 464
            PP+PP PP   P P               PK  S   KP P+P SP             P
Sbjct: 825  PPSPPTPPVPVPPP-------------TLPKQQSFCAKPPPSPLSPV------------P 859

Query: 465  SQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTP 524
            S ++++ ++          E + L   P   VAPQS    K  +   + + + +P+ D P
Sbjct: 860  SVVKQIASQFPPPPTPPAMESQPLKPVPA-NVAPQSPPAVKA-KPKWQPSSIPVPSPDFP 917

Query: 525  PGVPEKSLGGSSLTETEAAPS-LTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAK 583
            P  PE     SSL      PS +  P     P  SPTP       +  ++ SS   K  K
Sbjct: 918  PPPPE-----SSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGK--K 970

Query: 584  PSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPP 643
            P     PP P+        +GA+  +  +P   +L  + T    + S   + +  PA PP
Sbjct: 971  P-----PPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPP 1025

Query: 644  K---------------------------------ATPEPAIPPKATLWPATPPKATLGPA 670
            K                                 +  E   PP  + +P  PP+  L P 
Sbjct: 1026 KPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETEL-PL 1084

Query: 671  TPLK---ATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVST 727
             P++     SG T+P  A   P         P   S++  +K    A  P +P   + + 
Sbjct: 1085 PPIEIPAVFSGNTSPKVAVVNPQ--------PQQWSKMSVKK----APPPTRPKRNDSTR 1132

Query: 728  PSQARGEGSPSEATRLP 744
             +QA     P+ AT +P
Sbjct: 1133 LTQAEISEQPTMATVVP 1149



 Score =  121 bits (303), Expect = 5e-27
 Identities = 161/605 (26%), Positives = 224/605 (37%), Gaps = 155/605 (25%)

Query: 138  LIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSM----------- 186
            L+PP  P P    P   S+P    P P PP   PPPPP    PPPPP +           
Sbjct: 605  LVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPP----PPPPPPLPSQSAPSAGSA 660

Query: 187  ------------------------APPPPPVLEALS--------------------PPHT 202
                                     PP PPV+++ S                    PP T
Sbjct: 661  APMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPT 720

Query: 203  LSS--------PSIPTPPDFIPPAPPLAF------------LAPPPPPVPAPAPP-APAS 241
              S        P  P+ P F  P PPL                PPPPP+PAP PP AP  
Sbjct: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPK 780

Query: 242  PHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRS 301
            P        P    TK  + V         T+A+PP +P  P      P  +    FP S
Sbjct: 781  PLVT----IPAPTSTKTVAPV--------VTQAAPP-TPTPPV-----PPAKKQPAFPAS 822

Query: 302  FKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPD 361
            + +PP  P  T  +PV      P+++    K  PS L   PS   + ASQ  P   P   
Sbjct: 823  Y-IPPSPP--TPPVPV-PPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAM 878

Query: 362  CPGELKA----TAPASPRLGQSQSQADERAGTPPPAPPLPPPAP------PLPPPAP-PL 410
                LK      AP SP   +++ +  + +  P P+P  PPP P      P PPP+P P 
Sbjct: 879  ESQPLKPVPANVAPQSPPAVKAKPKW-QPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPA 937

Query: 411  PPAAPP---LPCAQKAAHPPAGFTKTPKSSSP-ALKPKPNPPSPENTASSAPVDWRDPSQ 466
            PP  PP    P   K+  P     KT K+SSP   KP P P    +  SS+  +  +P +
Sbjct: 938  PPPPPPPTASPTPDKSGSPG---KKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKR 994

Query: 467  MEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQ-SKEGKKGPRLP---------EKETLL 516
               + + ++ +   +          P P   P+  K    G  LP          K  +L
Sbjct: 995  -PSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVL 1053

Query: 517  SLPAKDTP---PGVPEKSLGGSSLTETE-AAPSLTLPSVDYIPQDSPTPSVRQIRNELEA 572
            S   KD+    P  P  S       ETE   P + +P+V +    SP  +V         
Sbjct: 1054 SGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAV-FSGNTSPKVAV--------- 1103

Query: 573  RLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQ 632
             ++   ++ +K S+   PP  R +         D  +L++      P  + T++P     
Sbjct: 1104 -VNPQPQQWSKMSVKKAPPPTRPKRN-------DSTRLTQAEISEQPTMA-TVVPQVPTS 1154

Query: 633  PKAML 637
            PK+ L
Sbjct: 1155 PKSSL 1159



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 157/654 (24%), Positives = 227/654 (34%), Gaps = 124/654 (18%)

Query: 306  PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGE 365
            P   VR+ SI      EA ++     + + +R+        RP + + P  +P+P     
Sbjct: 563  PAGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMN----RPYTSLVPPLSPQPKIVTP 618

Query: 366  LKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPP--------- 416
              A+ P+ P               PPP PP PPP PP PPP PPLP  + P         
Sbjct: 619  YTASQPSPP--------------LPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMF 664

Query: 417  -----LPCAQKAAHPPAGFTKTPK---SSSPALKPK-----------PNPPSPENTASSA 457
                 +   Q A+       K P      S ++KP+           P PP P  T  SA
Sbjct: 665  VKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSA 724

Query: 458  PVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLS 517
                +       L    A        + + ++    PT  P        P     + L++
Sbjct: 725  MAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVT 784

Query: 518  LPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSV-----------DYIPQDSPTPSVRQI 566
            +PA  +   V        +   T+AAP    P V            YIP   PTP V   
Sbjct: 785  IPAPTSTKTV--------APVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVP 836

Query: 567  RNELEARLSSAAEKEAKP----------SIGSLPPKPRLEGGRICENGADDDKLSKPVAK 616
               L  + S  A+    P               PP P           A + +  KPV  
Sbjct: 837  PPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPP--------TPPAMESQPLKPVPA 888

Query: 617  NLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE-PAIPPKATL-WPATPPKATLGPATPLK 674
            N+ PQS    P    +PK    P+  P  +P+ P  PP+++L +P  PP     P  P  
Sbjct: 889  NVAPQSP---PAVKAKPKWQ--PSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPP 943

Query: 675  ATSGPTTPLKATSGPAIASTAT----TLPTTTSQLMAEKDSGPAGQPE--KPASQE-VST 727
             T+ PT     + G   + T++      P T  +  + K S  A  PE  +P+    VS 
Sbjct: 944  PTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSK 1003

Query: 728  PSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMP 787
             +     GSPS+ T LP   A      P K +  G  +P + +  C        V+   P
Sbjct: 1004 FTPPAESGSPSKET-LPPPAAPPK---PGKLNLSGVNLPGVLQQGC--------VSAKAP 1051

Query: 788  TLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQ 847
             L+     G    VE   PP     PP    P  EL   P+    V  G+    +     
Sbjct: 1052 VLS---GRGKDSVVEFPSPPSDSDFPP--PPPETELPLPPIEIPAVFSGNTSPKVAVVNP 1106

Query: 848  RAQKGRSVGAALGRSSLPGSLRDHSH--QAEASSDSIFHSQGTPNSFTVVPKLP 899
            + Q+   +              D +   QAE S          P   TVVP++P
Sbjct: 1107 QPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQ--------PTMATVVPQVP 1152



 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 85/345 (24%), Positives = 115/345 (33%), Gaps = 89/345 (25%)

Query: 139  IPPPPPGPAPGPPQD--ISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAP-------- 188
            IP P P   P PP+   +  PP  SP+P+P    PPPPP    P P  S +P        
Sbjct: 909  IPVPSPDFPPPPPESSLVFPPPPPSPVPAP----PPPPPPTASPTPDKSGSPGKKTSKTS 964

Query: 189  -----PPPPVLEALSPPHTLSSPSIPTP---------PDFIPPA---PPLAFLAPPPPPV 231
                  PPP  +  S   + S    P P           F PPA    P     PPP   
Sbjct: 965  SPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPP--- 1021

Query: 232  PAPAPPAPASPHTVGTRL---FPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSAL 288
               APP P   +  G  L      G V+     ++  G+ +     SPP     P     
Sbjct: 1022 --AAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPE 1079

Query: 289  GPNPEPHLTFPRSFK--------VPPPTPVRTSSIPVQEA--------QEAPRKEEGATK 332
               P P +  P  F         V  P P + S + V++A         ++ R  +    
Sbjct: 1080 TELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEIS 1139

Query: 333  KAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASP-----RLGQSQSQADERA 387
            + P+   + P     P S +    + +P    +L  T           L    S+A+  A
Sbjct: 1140 EQPTMATVVPQVPTSPKSSL----SVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTA 1195

Query: 388  GTPPPAPPLPPPAPPL-----------------------PPPAPP 409
                 A  LPPP P L                       PPPAPP
Sbjct: 1196 TMDDMA--LPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAPP 1238



 Score = 53.9 bits (128), Expect = 9e-07
 Identities = 126/565 (22%), Positives = 177/565 (31%), Gaps = 77/565 (13%)

Query: 602  ENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPAT 661
            + G   ++ SK   +++    T+L+P  S QPK +         TP  A  P   L P  
Sbjct: 582  KRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIV---------TPYTASQPSPPLPPPP 632

Query: 662  PPKATLGPATPLKATSGPTTPLKATSGPAIASTATTL---PTTTSQLMAEKDSGPAGQPE 718
            PP     P  P      P  PL + S P+  S A       T T    A + SG   +P 
Sbjct: 633  PP-----PPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPP 687

Query: 719  KPA---SQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKP---- 771
             P    SQ V         G        P      SA    K +P    +P    P    
Sbjct: 688  TPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPL 747

Query: 772  HCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQ-PTDELLRHPVTG 830
              HQ     +VA   P         P  P+    PP  P KP  +   PT      PV  
Sbjct: 748  KIHQVQHITQVAPPTPP--------PPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVT 799

Query: 831  EVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPN 890
            +         +  A +Q A     +  +     +P        Q        F ++  P+
Sbjct: 800  QAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQS------FCAKPPPS 853

Query: 891  SFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVA 950
              + VP + K+     P     P    P +                + +P  PV    VA
Sbjct: 854  PLSPVPSVVKQIASQFP-----PPPTPPAM----------------ESQPLKPVP-ANVA 891

Query: 951  PSNLPQGHPLPK-SFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQ 1009
            P + P     PK   SS P PS        E +    PPPP     P PP P        
Sbjct: 892  PQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPT----AS 947

Query: 1010 SSPPRNNYSDLRQLPNAGPGA--PPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLY 1067
             +P ++     +    + PG   PP     R  +    +GA   E       SL+ K   
Sbjct: 948  PTPDKSGSPGKKTSKTSSPGGKKPPPTP-QRNSSIKSSSGAEHPEPKRPSVDSLVSKFT- 1005

Query: 1068 VGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAAR 1127
                   P    G   +    P    P+PG   +  VN  G    G + A    L G  +
Sbjct: 1006 -------PPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGK 1058

Query: 1128 GAAEAKHKAPGSADYGFAPAAGRSP 1152
             +       P  +D+   P     P
Sbjct: 1059 DSVVEFPSPPSDSDFPPPPPETELP 1083



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 47/196 (23%), Positives = 71/196 (36%), Gaps = 51/196 (26%)

Query: 854  SVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIP 913
            S+ +    SS+P S  +HS+Q++ S  S     G   S ++V  +  EA K         
Sbjct: 533  SIKSGSSSSSIPESQSNHSNQSD-SGVSDTQPAGHVRSQSIVSSVFSEAWKR-------- 583

Query: 914  NKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNK 973
                   G   E +  +R  +  +P       +  + P   PQ   +    +S PSP   
Sbjct: 584  -------GTQLEESSKARMESMNRP-------YTSLVPPLSPQPKIVTPYTASQPSPP-- 627

Query: 974  REEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNN-------YSDLRQLPNA 1026
                       + PPPP     P PP P    L  QS+P   +       YS + +L NA
Sbjct: 628  -----------LPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNA 676

Query: 1027 G--------PGAPPAL 1034
                     P  PP +
Sbjct: 677  SQHSGALFKPPTPPVM 692


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score =  119 bits (299), Expect = 1e-26
 Identities = 195/819 (23%), Positives = 282/819 (34%), Gaps = 126/819 (15%)

Query: 21  TTPSTSLYATNPPWIFTQEAPEEGTG-GFDGIYYGDNRFNTVSESGTATLKARPRVRPLL 79
           T+  TSL       + T+E          DG     +   T S   T+     P  + L 
Sbjct: 136 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 195

Query: 80  TFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLI 139
              P       G A+ TP  P     KE   T+        + S+               
Sbjct: 196 KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA--------------- 240

Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPP-----PPVL 194
           P  P  PAP   +     P     P+P +T  P P    EP P  +  P P      P  
Sbjct: 241 PTTPKEPAPTTTKSAPTTPKE---PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 297

Query: 195 EALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP-HTVGTRLFPPG 253
                P T   P+  TP +  P  P       P  P P    PAP +P     T    P 
Sbjct: 298 PKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 357

Query: 254 GVTKWKSDVALNGRQAEATRASP-PRSPAEPKGSALGPNP----EPHLTFPRSFKVPP-- 306
             T  +         A  T   P P +P EP  +     P    EP  T  +S    P  
Sbjct: 358 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 417

Query: 307 PTPVRTS----SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDC 362
           P+P  T     + P + A   P+K    T K P+  P  P       ++      P+   
Sbjct: 418 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA--PTTPKEPAPTTTKKPAPTTPKEPA 475

Query: 363 PGELKATAPASPRLGQSQSQADERAGTPP--PAPPLP----PPAPPLPPPAPPLPPAAPP 416
           P   K TAP +P+   + +  ++ A T P  PAP  P    P  P  P P  P  P AP 
Sbjct: 476 PTTPKETAPTTPK-KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP-APT 533

Query: 417 LPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA-----SSAPVDWRDPSQMEKLR 471
            P A     P      TPK  +P    +P P +P+ TA      +AP   ++P+     +
Sbjct: 534 TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK 593

Query: 472 ---NELAAYLCGSRREDRFLSHRPGPT----VAPQSKEGKKGPRLPEK----------ET 514
               ELA     ++        +P PT     AP + + +  P  P++           T
Sbjct: 594 PAPKELAP--TTTKEPTSTTCDKPAPTTPKGTAPTTPK-EPAPTTPKEPAPTTPKGTAPT 650

Query: 515 LLSLPAKDTPPGVPEKSL------GGSSLTETEAAPSL---TLPSVDYIP---------- 555
            L  PA  TP     K L      G +S T  + AP+    T P+    P          
Sbjct: 651 TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAP 710

Query: 556 --QDSPTPSVRQIRNELEARLSSAAEK---EAKPSIGSLPPKPRLEGGRICENGADDDK- 609
              ++P P+  ++      +  +   K   E+ P + + P    LE     E G    K 
Sbjct: 711 TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP-KEPGVPTTKT 769

Query: 610 --LSKPVAKNLPPQST------TLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPAT 661
              +KP         T      T   TT+  PK     A   + T E  I    T   +T
Sbjct: 770 PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 829

Query: 662 PPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPA 721
             + T    TP K T+  TT    T  P + +T  T+ TT      E+ + P    ++  
Sbjct: 830 TTQDT----TPFKITTLKTT----TLAPKVTTTKKTITTTEIMNKPEETAKP---KDRAT 878

Query: 722 SQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSP 760
           + + +TP   +    P++A + PT   +      PKT P
Sbjct: 879 NSKATTPKPQK----PTKAPKKPTSTKK------PKTMP 907



 Score =  119 bits (298), Expect = 2e-26
 Identities = 176/711 (24%), Positives = 246/711 (34%), Gaps = 121/711 (17%)

Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPP------PSMAPPPPPV 193
           P  P  PAP  P+   EP   +P    P+T  P P    EP P       P+    P P 
Sbjct: 311 PTTPKEPAPTTPK---EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 367

Query: 194 LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP-----APPAPASPHTVGTR 248
                 P T   PS  TP +   PAP     AP     PAP     AP  P  P    T+
Sbjct: 368 TPKEPAPTTTKEPSPTTPKE---PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK 424

Query: 249 LFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT 308
              P   T  +       + A  T   P  +P  PK  A     +P  T P+  +  P T
Sbjct: 425 --EPAPTTPKEPAPTTPKKPAPTTPKEP--APTTPKEPAPTTTKKPAPTTPK--EPAPTT 478

Query: 309 PVRTS-SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPD-RAPEPDCPGEL 366
           P  T+ + P +     P K    T + P+  P  P   + P +   P    PE   P   
Sbjct: 479 PKETAPTTPKKLTPTTPEKLAPTTPEKPA--PTTPE-ELAPTTPEEPTPTTPEEPAPTTP 535

Query: 367 KATAPASPRLGQSQSQADERAGTPP-PAPPLPPPAPPLPP----------PAPPLPPAAP 415
           KA AP +P+     +  +    TP  PAP  P    P  P          PAP  P    
Sbjct: 536 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPA 595

Query: 416 PLPCAQKAAHPPAGFT------KTPKSSSPALKPKPNP-----PSPENTASSAPVDWRDP 464
           P   A      P   T       TPK ++P    +P P     P+P     +AP   ++P
Sbjct: 596 PKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEP 655

Query: 465 SQMEKLR---NELAAYLCGSRREDRFLSHRPGPTV----APQSKEGKKGPRLPEKETLLS 517
           +     +    ELA     ++      S +P PT     AP + + +  P  P+K     
Sbjct: 656 APTTPKKPAPKELAPTT--TKGPTSTTSDKPAPTTPKETAPTTPK-EPAPTTPKK----- 707

Query: 518 LPAKDTPPGVPEKSLGGSSLTET-----------EAAPSL----TLPSVDYIPQDSPTPS 562
            PA  TP   P  +   S+ T T           E+ P L    T  +++  P++   P+
Sbjct: 708 -PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT 766

Query: 563 VRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKL--SKPVAKNLPP 620
            +          ++A +K  +  + + P           E     +K   SK  A     
Sbjct: 767 TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 826

Query: 621 QSTTLLPTTSLQPKAMLGPAIPPKAT--------------PEPAIPPK--ATLWPATPPK 664
            STT   TT  +   +    + PK T              PE    PK  AT   AT PK
Sbjct: 827 TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPK 886

Query: 665 ATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQE 724
               P  P KA   PT+  K  + P +    TT PT         +  P  +  +   Q 
Sbjct: 887 ----PQKPTKAPKKPTSTKKPKTMPRVRKPKTT-PTPRKMTSTMPELNPTSRIAEAMLQT 941

Query: 725 VSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGG--GEVP-CLYKPH 772
            + P+Q              T  ++     P     GG  GE P  L +PH
Sbjct: 942 TTRPNQ--------------TPNSKLVEVNPKSEDAGGAEGETPHMLLRPH 978



 Score =  114 bits (285), Expect = 6e-25
 Identities = 188/762 (24%), Positives = 261/762 (34%), Gaps = 156/762 (20%)

Query: 164 PSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAF 223
           P+P +      P L  P  P    P  P       P  T    +  TP +   PAP    
Sbjct: 197 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKE---PAPTTTK 253

Query: 224 LAPPPPPVPAPAP---PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSP 280
            AP  P  PAP     PAP +P             T  KS        A  T   P  +P
Sbjct: 254 SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP--AP 311

Query: 281 AEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPL 340
             PK  A     EP  T P+  +  P T     + P + A  AP+K    T K P+    
Sbjct: 312 TTPKEPAPTTPKEPTPTTPK--EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA---- 365

Query: 341 PPSFHIRPASQVYPDRAPEPDCPGE-LKATAPASPRLGQSQSQADERAGTPPPAPPLPP- 398
            P+    PA      + P P  P E    T  ++P   +  +    ++    P  P P  
Sbjct: 366 -PTTPKEPAPTT--TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT 422

Query: 399 ---PAPPLPP-PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA 454
              PAP  P  PAP  P    P P   K   P      TPK  +P    KP P +P+  A
Sbjct: 423 TKEPAPTTPKEPAPTTPKK--PAPTTPKEPAPT-----TPKEPAPTTTKKPAPTTPKEPA 475

Query: 455 SSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKET 514
            + P +   P+  +KL                           P + E K  P  PEK  
Sbjct: 476 PTTPKETA-PTTPKKL--------------------------TPTTPE-KLAPTTPEK-- 505

Query: 515 LLSLPAKDTP----PGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL 570
               PA  TP    P  PE+    +  T  E AP+    +    P++ P P+        
Sbjct: 506 ----PAPTTPEELAPTTPEEP---TPTTPEEPAPTTPKAAAPNTPKE-PAPTT------- 550

Query: 571 EARLSSAAEKEAKPSIGSLP-PKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629
                    KE  P+    P P    E       G     L +P             PTT
Sbjct: 551 --------PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA------------PTT 590

Query: 630 SLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGP 689
              PK      + P  T EP         P TP K T  P TP +    PTTP +    P
Sbjct: 591 ---PKKPAPKELAPTTTKEPTSTTCDKPAPTTP-KGT-APTTPKEPA--PTTPKE----P 639

Query: 690 AIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGAR 749
           A  +   T PTT       K+  P   P+KPA +E++ P+  +G  S +     PT    
Sbjct: 640 APTTPKGTAPTTL------KEPAPT-TPKKPAPKELA-PTTTKGPTSTTSDKPAPTTPKE 691

Query: 750 SSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGL 809
           ++   P + +P   + P    P     + S    V  PT  +       EP  + + P  
Sbjct: 692 TAPTTPKEPAPTTPKKPAPTTPETPPPTTSE---VSTPTTTK-------EPTTIHKSPD- 740

Query: 810 PAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLR 869
            + P  SA+PT + L +       E G P     AA               +  +  + +
Sbjct: 741 ESTPELSAEPTPKALENSPK----EPGVPTTKTPAAT--------------KPEMTTTAK 782

Query: 870 DHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTE 911
           D + + +  +        TP + T  PK+ KE    +  TTE
Sbjct: 783 DKTTERDLRT--------TPETTTAAPKMTKETATTTEKTTE 816



 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 93/427 (21%), Positives = 137/427 (32%), Gaps = 53/427 (12%)

Query: 596  EGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKA 655
            +G     +  +   + K  AK+L P S  L   T        GPA+     P P  P + 
Sbjct: 165  DGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKE- 223

Query: 656  TLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAG 715
                  P   T    TP    S PTTP +    PA  +T  + PTT  +        PA 
Sbjct: 224  ------PASTTPKEPTPTTIKSAPTTPKE----PA-PTTTKSAPTTPKEPAPTTTKEPAP 272

Query: 716  Q-PEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCH 774
              P++PA      P+       P+     PT     +   P K +P   + P    P   
Sbjct: 273  TTPKEPAPTTTKEPA-------PTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 325

Query: 775  QSSLSREVAVVMPTLARGGAAGPGEPVEV--KEPPGLPAKPPASAQPTDELLRHPVTGEV 832
              +  +E A   PT        P EP     K+P     K PA   P +     P T + 
Sbjct: 326  TPTTPKEPA---PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA---PTTTKE 379

Query: 833  VERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNS- 891
                +P        + A       A     S P + ++ S             +  P + 
Sbjct: 380  PSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTP 439

Query: 892  --------FTVVPKLPKE-----AEKDSPLTTEIPNKWGPRLGRDAEGTELS----RRHN 934
                        P  PKE      +K +P T + P    P+        +L+     +  
Sbjct: 440  KKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLA 499

Query: 935  WTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSN 994
             T PE  AP   E +AP+   +  P      +P +P        +E       P P    
Sbjct: 500  PTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE-------PAPTTPK 552

Query: 995  DPEPPAP 1001
            +P P  P
Sbjct: 553  EPAPTTP 559



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 96/465 (20%), Positives = 146/465 (31%), Gaps = 90/465 (19%)

Query: 591  PKPRL--EGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648
            PKP +  E G   +NG  D K++ P        STT     S  PK      I P+    
Sbjct: 80   PKPPVVDEAGSGLDNG--DFKVTTP------DTSTTQHNKVSTSPKITTAKPINPR---- 127

Query: 649  PAIPPKATLWPATPPKATLGPATPLKA-------TSGPTTPLKATSGPAIASTATTLPTT 701
                      P+ PP +     T L         T   TT  K TS      T +   T 
Sbjct: 128  ----------PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQ 177

Query: 702  TSQLMAEKDSGPAGQ----------------------------PEKPASQEVSTPSQARG 733
            + +  + KD  P  +                            P++PAS     P+    
Sbjct: 178  SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI 237

Query: 734  EGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGG 793
            + +P+          +S+   P + +P   + P    P     + ++E A   PT  +  
Sbjct: 238  KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA---PTTTKSA 294

Query: 794  AAGPGEPVEV---KEPPGLPAKP----PASAQPTDELLRHPVTGEVVERGSPMALLLAAR 846
               P EP      K  P  P +P    P    PT      P T E            A +
Sbjct: 295  PTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPK 354

Query: 847  QRA-QKGRSVGAALGRSSLPGSLRDHS-------HQAEASSDSIFHSQGTPNSFTVVPKL 898
            + A    +       +   P + ++ S             S      +  P +    P  
Sbjct: 355  KPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTT 414

Query: 899  PKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGH 958
            PKE    SP TT+ P    P+           ++   T P+  AP   +  AP+   +  
Sbjct: 415  PKE---PSPTTTKEPAPTTPK----EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 467

Query: 959  PLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPE--FSNDPEPPAP 1001
            P      +P +P    +E       ++ P  PE      PE PAP
Sbjct: 468  PTTPKEPAPTTP----KETAPTTPKKLTPTTPEKLAPTTPEKPAP 508


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score =  119 bits (299), Expect = 1e-26
 Identities = 195/819 (23%), Positives = 282/819 (34%), Gaps = 126/819 (15%)

Query: 21  TTPSTSLYATNPPWIFTQEAPEEGTG-GFDGIYYGDNRFNTVSESGTATLKARPRVRPLL 79
           T+  TSL       + T+E          DG     +   T S   T+     P  + L 
Sbjct: 177 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 236

Query: 80  TFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLI 139
              P       G A+ TP  P     KE   T+        + S+               
Sbjct: 237 KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA--------------- 281

Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPP-----PPVL 194
           P  P  PAP   +     P     P+P +T  P P    EP P  +  P P      P  
Sbjct: 282 PTTPKEPAPTTTKSAPTTPKE---PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 338

Query: 195 EALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP-HTVGTRLFPPG 253
                P T   P+  TP +  P  P       P  P P    PAP +P     T    P 
Sbjct: 339 PKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 398

Query: 254 GVTKWKSDVALNGRQAEATRASP-PRSPAEPKGSALGPNP----EPHLTFPRSFKVPP-- 306
             T  +         A  T   P P +P EP  +     P    EP  T  +S    P  
Sbjct: 399 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 458

Query: 307 PTPVRTS----SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDC 362
           P+P  T     + P + A   P+K    T K P+  P  P       ++      P+   
Sbjct: 459 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA--PTTPKEPAPTTTKKPAPTTPKEPA 516

Query: 363 PGELKATAPASPRLGQSQSQADERAGTPP--PAPPLP----PPAPPLPPPAPPLPPAAPP 416
           P   K TAP +P+   + +  ++ A T P  PAP  P    P  P  P P  P  P AP 
Sbjct: 517 PTTPKETAPTTPK-KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP-APT 574

Query: 417 LPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA-----SSAPVDWRDPSQMEKLR 471
            P A     P      TPK  +P    +P P +P+ TA      +AP   ++P+     +
Sbjct: 575 TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK 634

Query: 472 ---NELAAYLCGSRREDRFLSHRPGPT----VAPQSKEGKKGPRLPEK----------ET 514
               ELA     ++        +P PT     AP + + +  P  P++           T
Sbjct: 635 PAPKELAP--TTTKEPTSTTCDKPAPTTPKGTAPTTPK-EPAPTTPKEPAPTTPKGTAPT 691

Query: 515 LLSLPAKDTPPGVPEKSL------GGSSLTETEAAPSL---TLPSVDYIP---------- 555
            L  PA  TP     K L      G +S T  + AP+    T P+    P          
Sbjct: 692 TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAP 751

Query: 556 --QDSPTPSVRQIRNELEARLSSAAEK---EAKPSIGSLPPKPRLEGGRICENGADDDK- 609
              ++P P+  ++      +  +   K   E+ P + + P    LE     E G    K 
Sbjct: 752 TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP-KEPGVPTTKT 810

Query: 610 --LSKPVAKNLPPQST------TLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPAT 661
              +KP         T      T   TT+  PK     A   + T E  I    T   +T
Sbjct: 811 PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 870

Query: 662 PPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPA 721
             + T    TP K T+  TT    T  P + +T  T+ TT      E+ + P    ++  
Sbjct: 871 TTQDT----TPFKITTLKTT----TLAPKVTTTKKTITTTEIMNKPEETAKP---KDRAT 919

Query: 722 SQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSP 760
           + + +TP   +    P++A + PT   +      PKT P
Sbjct: 920 NSKATTPKPQK----PTKAPKKPTSTKK------PKTMP 948



 Score =  119 bits (298), Expect = 2e-26
 Identities = 176/711 (24%), Positives = 246/711 (34%), Gaps = 121/711 (17%)

Query: 140  PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPP------PSMAPPPPPV 193
            P  P  PAP  P+   EP   +P    P+T  P P    EP P       P+    P P 
Sbjct: 352  PTTPKEPAPTTPK---EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 408

Query: 194  LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP-----APPAPASPHTVGTR 248
                  P T   PS  TP +   PAP     AP     PAP     AP  P  P    T+
Sbjct: 409  TPKEPAPTTTKEPSPTTPKE---PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK 465

Query: 249  LFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT 308
               P   T  +       + A  T   P  +P  PK  A     +P  T P+  +  P T
Sbjct: 466  --EPAPTTPKEPAPTTPKKPAPTTPKEP--APTTPKEPAPTTTKKPAPTTPK--EPAPTT 519

Query: 309  PVRTS-SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPD-RAPEPDCPGEL 366
            P  T+ + P +     P K    T + P+  P  P   + P +   P    PE   P   
Sbjct: 520  PKETAPTTPKKLTPTTPEKLAPTTPEKPA--PTTPE-ELAPTTPEEPTPTTPEEPAPTTP 576

Query: 367  KATAPASPRLGQSQSQADERAGTPP-PAPPLPPPAPPLPP----------PAPPLPPAAP 415
            KA AP +P+     +  +    TP  PAP  P    P  P          PAP  P    
Sbjct: 577  KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPA 636

Query: 416  PLPCAQKAAHPPAGFT------KTPKSSSPALKPKPNP-----PSPENTASSAPVDWRDP 464
            P   A      P   T       TPK ++P    +P P     P+P     +AP   ++P
Sbjct: 637  PKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEP 696

Query: 465  SQMEKLR---NELAAYLCGSRREDRFLSHRPGPTV----APQSKEGKKGPRLPEKETLLS 517
            +     +    ELA     ++      S +P PT     AP + + +  P  P+K     
Sbjct: 697  APTTPKKPAPKELAPTT--TKGPTSTTSDKPAPTTPKETAPTTPK-EPAPTTPKK----- 748

Query: 518  LPAKDTPPGVPEKSLGGSSLTET-----------EAAPSL----TLPSVDYIPQDSPTPS 562
             PA  TP   P  +   S+ T T           E+ P L    T  +++  P++   P+
Sbjct: 749  -PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT 807

Query: 563  VRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKL--SKPVAKNLPP 620
             +          ++A +K  +  + + P           E     +K   SK  A     
Sbjct: 808  TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 867

Query: 621  QSTTLLPTTSLQPKAMLGPAIPPKAT--------------PEPAIPPK--ATLWPATPPK 664
             STT   TT  +   +    + PK T              PE    PK  AT   AT PK
Sbjct: 868  TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPK 927

Query: 665  ATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQE 724
                P  P KA   PT+  K  + P +    TT PT         +  P  +  +   Q 
Sbjct: 928  ----PQKPTKAPKKPTSTKKPKTMPRVRKPKTT-PTPRKMTSTMPELNPTSRIAEAMLQT 982

Query: 725  VSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGG--GEVP-CLYKPH 772
             + P+Q              T  ++     P     GG  GE P  L +PH
Sbjct: 983  TTRPNQ--------------TPNSKLVEVNPKSEDAGGAEGETPHMLLRPH 1019



 Score =  114 bits (285), Expect = 6e-25
 Identities = 188/762 (24%), Positives = 261/762 (34%), Gaps = 156/762 (20%)

Query: 164 PSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAF 223
           P+P +      P L  P  P    P  P       P  T    +  TP +   PAP    
Sbjct: 238 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKE---PAPTTTK 294

Query: 224 LAPPPPPVPAPAP---PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSP 280
            AP  P  PAP     PAP +P             T  KS        A  T   P  +P
Sbjct: 295 SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP--AP 352

Query: 281 AEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPL 340
             PK  A     EP  T P+  +  P T     + P + A  AP+K    T K P+    
Sbjct: 353 TTPKEPAPTTPKEPTPTTPK--EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA---- 406

Query: 341 PPSFHIRPASQVYPDRAPEPDCPGE-LKATAPASPRLGQSQSQADERAGTPPPAPPLPP- 398
            P+    PA      + P P  P E    T  ++P   +  +    ++    P  P P  
Sbjct: 407 -PTTPKEPAPTT--TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT 463

Query: 399 ---PAPPLPP-PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA 454
              PAP  P  PAP  P    P P   K   P      TPK  +P    KP P +P+  A
Sbjct: 464 TKEPAPTTPKEPAPTTPKK--PAPTTPKEPAPT-----TPKEPAPTTTKKPAPTTPKEPA 516

Query: 455 SSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKET 514
            + P +   P+  +KL                           P + E K  P  PEK  
Sbjct: 517 PTTPKETA-PTTPKKL--------------------------TPTTPE-KLAPTTPEK-- 546

Query: 515 LLSLPAKDTP----PGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL 570
               PA  TP    P  PE+    +  T  E AP+    +    P++ P P+        
Sbjct: 547 ----PAPTTPEELAPTTPEEP---TPTTPEEPAPTTPKAAAPNTPKE-PAPTT------- 591

Query: 571 EARLSSAAEKEAKPSIGSLP-PKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629
                    KE  P+    P P    E       G     L +P             PTT
Sbjct: 592 --------PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA------------PTT 631

Query: 630 SLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGP 689
              PK      + P  T EP         P TP K T  P TP +    PTTP +    P
Sbjct: 632 ---PKKPAPKELAPTTTKEPTSTTCDKPAPTTP-KGT-APTTPKEPA--PTTPKE----P 680

Query: 690 AIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGAR 749
           A  +   T PTT       K+  P   P+KPA +E++ P+  +G  S +     PT    
Sbjct: 681 APTTPKGTAPTTL------KEPAPT-TPKKPAPKELA-PTTTKGPTSTTSDKPAPTTPKE 732

Query: 750 SSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGL 809
           ++   P + +P   + P    P     + S    V  PT  +       EP  + + P  
Sbjct: 733 TAPTTPKEPAPTTPKKPAPTTPETPPPTTSE---VSTPTTTK-------EPTTIHKSPD- 781

Query: 810 PAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLR 869
            + P  SA+PT + L +       E G P     AA               +  +  + +
Sbjct: 782 ESTPELSAEPTPKALENSPK----EPGVPTTKTPAAT--------------KPEMTTTAK 823

Query: 870 DHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTE 911
           D + + +  +        TP + T  PK+ KE    +  TTE
Sbjct: 824 DKTTERDLRT--------TPETTTAAPKMTKETATTTEKTTE 857



 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 93/427 (21%), Positives = 137/427 (32%), Gaps = 53/427 (12%)

Query: 596  EGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKA 655
            +G     +  +   + K  AK+L P S  L   T        GPA+     P P  P + 
Sbjct: 206  DGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKE- 264

Query: 656  TLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAG 715
                  P   T    TP    S PTTP +    PA  +T  + PTT  +        PA 
Sbjct: 265  ------PASTTPKEPTPTTIKSAPTTPKE----PA-PTTTKSAPTTPKEPAPTTTKEPAP 313

Query: 716  Q-PEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCH 774
              P++PA      P+       P+     PT     +   P K +P   + P    P   
Sbjct: 314  TTPKEPAPTTTKEPA-------PTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 366

Query: 775  QSSLSREVAVVMPTLARGGAAGPGEPVEV--KEPPGLPAKPPASAQPTDELLRHPVTGEV 832
              +  +E A   PT        P EP     K+P     K PA   P +     P T + 
Sbjct: 367  TPTTPKEPA---PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA---PTTTKE 420

Query: 833  VERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNS- 891
                +P        + A       A     S P + ++ S             +  P + 
Sbjct: 421  PSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTP 480

Query: 892  --------FTVVPKLPKE-----AEKDSPLTTEIPNKWGPRLGRDAEGTELS----RRHN 934
                        P  PKE      +K +P T + P    P+        +L+     +  
Sbjct: 481  KKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLA 540

Query: 935  WTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSN 994
             T PE  AP   E +AP+   +  P      +P +P        +E       P P    
Sbjct: 541  PTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE-------PAPTTPK 593

Query: 995  DPEPPAP 1001
            +P P  P
Sbjct: 594  EPAPTTP 600



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 96/465 (20%), Positives = 146/465 (31%), Gaps = 90/465 (19%)

Query: 591  PKPRL--EGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648
            PKP +  E G   +NG  D K++ P        STT     S  PK      I P+    
Sbjct: 121  PKPPVVDEAGSGLDNG--DFKVTTP------DTSTTQHNKVSTSPKITTAKPINPR---- 168

Query: 649  PAIPPKATLWPATPPKATLGPATPLKA-------TSGPTTPLKATSGPAIASTATTLPTT 701
                      P+ PP +     T L         T   TT  K TS      T +   T 
Sbjct: 169  ----------PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQ 218

Query: 702  TSQLMAEKDSGPAGQ----------------------------PEKPASQEVSTPSQARG 733
            + +  + KD  P  +                            P++PAS     P+    
Sbjct: 219  SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI 278

Query: 734  EGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGG 793
            + +P+          +S+   P + +P   + P    P     + ++E A   PT  +  
Sbjct: 279  KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA---PTTTKSA 335

Query: 794  AAGPGEPVEV---KEPPGLPAKP----PASAQPTDELLRHPVTGEVVERGSPMALLLAAR 846
               P EP      K  P  P +P    P    PT      P T E            A +
Sbjct: 336  PTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPK 395

Query: 847  QRA-QKGRSVGAALGRSSLPGSLRDHS-------HQAEASSDSIFHSQGTPNSFTVVPKL 898
            + A    +       +   P + ++ S             S      +  P +    P  
Sbjct: 396  KPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTT 455

Query: 899  PKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGH 958
            PKE    SP TT+ P    P+           ++   T P+  AP   +  AP+   +  
Sbjct: 456  PKE---PSPTTTKEPAPTTPK----EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 508

Query: 959  PLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPE--FSNDPEPPAP 1001
            P      +P +P    +E       ++ P  PE      PE PAP
Sbjct: 509  PTTPKEPAPTTP----KETAPTTPKKLTPTTPEKLAPTTPEKPAP 549


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score =  119 bits (299), Expect = 1e-26
 Identities = 195/819 (23%), Positives = 282/819 (34%), Gaps = 126/819 (15%)

Query: 21   TTPSTSLYATNPPWIFTQEAPEEGTG-GFDGIYYGDNRFNTVSESGTATLKARPRVRPLL 79
            T+  TSL       + T+E          DG     +   T S   T+     P  + L 
Sbjct: 229  TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 288

Query: 80   TFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLI 139
               P       G A+ TP  P     KE   T+        + S+               
Sbjct: 289  KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA--------------- 333

Query: 140  PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPP-----PPVL 194
            P  P  PAP   +     P     P+P +T  P P    EP P  +  P P      P  
Sbjct: 334  PTTPKEPAPTTTKSAPTTPKE---PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 390

Query: 195  EALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP-HTVGTRLFPPG 253
                 P T   P+  TP +  P  P       P  P P    PAP +P     T    P 
Sbjct: 391  PKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 450

Query: 254  GVTKWKSDVALNGRQAEATRASP-PRSPAEPKGSALGPNP----EPHLTFPRSFKVPP-- 306
              T  +         A  T   P P +P EP  +     P    EP  T  +S    P  
Sbjct: 451  PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 510

Query: 307  PTPVRTS----SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDC 362
            P+P  T     + P + A   P+K    T K P+  P  P       ++      P+   
Sbjct: 511  PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA--PTTPKEPAPTTTKKPAPTTPKEPA 568

Query: 363  PGELKATAPASPRLGQSQSQADERAGTPP--PAPPLP----PPAPPLPPPAPPLPPAAPP 416
            P   K TAP +P+   + +  ++ A T P  PAP  P    P  P  P P  P  P AP 
Sbjct: 569  PTTPKETAPTTPK-KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP-APT 626

Query: 417  LPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA-----SSAPVDWRDPSQMEKLR 471
             P A     P      TPK  +P    +P P +P+ TA      +AP   ++P+     +
Sbjct: 627  TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK 686

Query: 472  ---NELAAYLCGSRREDRFLSHRPGPT----VAPQSKEGKKGPRLPEK----------ET 514
                ELA     ++        +P PT     AP + + +  P  P++           T
Sbjct: 687  PAPKELAP--TTTKEPTSTTCDKPAPTTPKGTAPTTPK-EPAPTTPKEPAPTTPKGTAPT 743

Query: 515  LLSLPAKDTPPGVPEKSL------GGSSLTETEAAPSL---TLPSVDYIP---------- 555
             L  PA  TP     K L      G +S T  + AP+    T P+    P          
Sbjct: 744  TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAP 803

Query: 556  --QDSPTPSVRQIRNELEARLSSAAEK---EAKPSIGSLPPKPRLEGGRICENGADDDK- 609
               ++P P+  ++      +  +   K   E+ P + + P    LE     E G    K 
Sbjct: 804  TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP-KEPGVPTTKT 862

Query: 610  --LSKPVAKNLPPQST------TLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPAT 661
               +KP         T      T   TT+  PK     A   + T E  I    T   +T
Sbjct: 863  PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 922

Query: 662  PPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPA 721
              + T    TP K T+  TT    T  P + +T  T+ TT      E+ + P    ++  
Sbjct: 923  TTQDT----TPFKITTLKTT----TLAPKVTTTKKTITTTEIMNKPEETAKP---KDRAT 971

Query: 722  SQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSP 760
            + + +TP   +    P++A + PT   +      PKT P
Sbjct: 972  NSKATTPKPQK----PTKAPKKPTSTKK------PKTMP 1000



 Score =  119 bits (298), Expect = 2e-26
 Identities = 176/711 (24%), Positives = 246/711 (34%), Gaps = 121/711 (17%)

Query: 140  PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPP------PSMAPPPPPV 193
            P  P  PAP  P+   EP   +P    P+T  P P    EP P       P+    P P 
Sbjct: 404  PTTPKEPAPTTPK---EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 460

Query: 194  LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP-----APPAPASPHTVGTR 248
                  P T   PS  TP +   PAP     AP     PAP     AP  P  P    T+
Sbjct: 461  TPKEPAPTTTKEPSPTTPKE---PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK 517

Query: 249  LFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT 308
               P   T  +       + A  T   P  +P  PK  A     +P  T P+  +  P T
Sbjct: 518  --EPAPTTPKEPAPTTPKKPAPTTPKEP--APTTPKEPAPTTTKKPAPTTPK--EPAPTT 571

Query: 309  PVRTS-SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPD-RAPEPDCPGEL 366
            P  T+ + P +     P K    T + P+  P  P   + P +   P    PE   P   
Sbjct: 572  PKETAPTTPKKLTPTTPEKLAPTTPEKPA--PTTPE-ELAPTTPEEPTPTTPEEPAPTTP 628

Query: 367  KATAPASPRLGQSQSQADERAGTPP-PAPPLPPPAPPLPP----------PAPPLPPAAP 415
            KA AP +P+     +  +    TP  PAP  P    P  P          PAP  P    
Sbjct: 629  KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPA 688

Query: 416  PLPCAQKAAHPPAGFT------KTPKSSSPALKPKPNP-----PSPENTASSAPVDWRDP 464
            P   A      P   T       TPK ++P    +P P     P+P     +AP   ++P
Sbjct: 689  PKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEP 748

Query: 465  SQMEKLR---NELAAYLCGSRREDRFLSHRPGPTV----APQSKEGKKGPRLPEKETLLS 517
            +     +    ELA     ++      S +P PT     AP + + +  P  P+K     
Sbjct: 749  APTTPKKPAPKELAPTT--TKGPTSTTSDKPAPTTPKETAPTTPK-EPAPTTPKK----- 800

Query: 518  LPAKDTPPGVPEKSLGGSSLTET-----------EAAPSL----TLPSVDYIPQDSPTPS 562
             PA  TP   P  +   S+ T T           E+ P L    T  +++  P++   P+
Sbjct: 801  -PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT 859

Query: 563  VRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKL--SKPVAKNLPP 620
             +          ++A +K  +  + + P           E     +K   SK  A     
Sbjct: 860  TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 919

Query: 621  QSTTLLPTTSLQPKAMLGPAIPPKAT--------------PEPAIPPK--ATLWPATPPK 664
             STT   TT  +   +    + PK T              PE    PK  AT   AT PK
Sbjct: 920  TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPK 979

Query: 665  ATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQE 724
                P  P KA   PT+  K  + P +    TT PT         +  P  +  +   Q 
Sbjct: 980  ----PQKPTKAPKKPTSTKKPKTMPRVRKPKTT-PTPRKMTSTMPELNPTSRIAEAMLQT 1034

Query: 725  VSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGG--GEVP-CLYKPH 772
             + P+Q              T  ++     P     GG  GE P  L +PH
Sbjct: 1035 TTRPNQ--------------TPNSKLVEVNPKSEDAGGAEGETPHMLLRPH 1071



 Score =  114 bits (285), Expect = 6e-25
 Identities = 188/762 (24%), Positives = 261/762 (34%), Gaps = 156/762 (20%)

Query: 164 PSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAF 223
           P+P +      P L  P  P    P  P       P  T    +  TP +   PAP    
Sbjct: 290 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKE---PAPTTTK 346

Query: 224 LAPPPPPVPAPAP---PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSP 280
            AP  P  PAP     PAP +P             T  KS        A  T   P  +P
Sbjct: 347 SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP--AP 404

Query: 281 AEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPL 340
             PK  A     EP  T P+  +  P T     + P + A  AP+K    T K P+    
Sbjct: 405 TTPKEPAPTTPKEPTPTTPK--EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA---- 458

Query: 341 PPSFHIRPASQVYPDRAPEPDCPGE-LKATAPASPRLGQSQSQADERAGTPPPAPPLPP- 398
            P+    PA      + P P  P E    T  ++P   +  +    ++    P  P P  
Sbjct: 459 -PTTPKEPAPTT--TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT 515

Query: 399 ---PAPPLPP-PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA 454
              PAP  P  PAP  P    P P   K   P      TPK  +P    KP P +P+  A
Sbjct: 516 TKEPAPTTPKEPAPTTPKK--PAPTTPKEPAPT-----TPKEPAPTTTKKPAPTTPKEPA 568

Query: 455 SSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKET 514
            + P +   P+  +KL                           P + E K  P  PEK  
Sbjct: 569 PTTPKETA-PTTPKKL--------------------------TPTTPE-KLAPTTPEK-- 598

Query: 515 LLSLPAKDTP----PGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL 570
               PA  TP    P  PE+    +  T  E AP+    +    P++ P P+        
Sbjct: 599 ----PAPTTPEELAPTTPEEP---TPTTPEEPAPTTPKAAAPNTPKE-PAPTT------- 643

Query: 571 EARLSSAAEKEAKPSIGSLP-PKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629
                    KE  P+    P P    E       G     L +P             PTT
Sbjct: 644 --------PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA------------PTT 683

Query: 630 SLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGP 689
              PK      + P  T EP         P TP K T  P TP +    PTTP +    P
Sbjct: 684 ---PKKPAPKELAPTTTKEPTSTTCDKPAPTTP-KGT-APTTPKEPA--PTTPKE----P 732

Query: 690 AIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGAR 749
           A  +   T PTT       K+  P   P+KPA +E++ P+  +G  S +     PT    
Sbjct: 733 APTTPKGTAPTTL------KEPAPT-TPKKPAPKELA-PTTTKGPTSTTSDKPAPTTPKE 784

Query: 750 SSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGL 809
           ++   P + +P   + P    P     + S    V  PT  +       EP  + + P  
Sbjct: 785 TAPTTPKEPAPTTPKKPAPTTPETPPPTTSE---VSTPTTTK-------EPTTIHKSPD- 833

Query: 810 PAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLR 869
            + P  SA+PT + L +       E G P     AA               +  +  + +
Sbjct: 834 ESTPELSAEPTPKALENSPK----EPGVPTTKTPAAT--------------KPEMTTTAK 875

Query: 870 DHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTE 911
           D + + +  +        TP + T  PK+ KE    +  TTE
Sbjct: 876 DKTTERDLRT--------TPETTTAAPKMTKETATTTEKTTE 909



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 130/610 (21%), Positives = 200/610 (32%), Gaps = 60/610 (9%)

Query: 415  PPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNEL 474
            P  P + K A PP+G ++T KS++   K  P PP+ + T      +            E 
Sbjct: 69   PTSPPSSKKAPPPSGASQTIKSTT---KRSPKPPNKKKTKKVIESEEITEEHSVSENQES 125

Query: 475  AAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLG- 533
            ++    S         +     A   +  KK      K+          PP V E   G 
Sbjct: 126  SSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGL 185

Query: 534  --------GSSLTETEAAPSLTLPSVDYIPQDSPTPSV---RQIRNELEARLSSAAEKEA 582
                        + T+     T P +      +P PS+        E    ++     E 
Sbjct: 186  DNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVET 245

Query: 583  KPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIP 642
            K +  +   +   +G     +  +   + K  AK+L P S  L   T        GPA+ 
Sbjct: 246  KETT-TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALT 304

Query: 643  PKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTT 702
                P P  P +       P   T    TP    S PTTP +    PA  +T  + PTT 
Sbjct: 305  TPKEPTPTTPKE-------PASTTPKEPTPTTIKSAPTTPKE----PA-PTTTKSAPTTP 352

Query: 703  SQLMAEKDSGPA-GQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPG 761
             +        PA   P++PA      P       +P+     PT     +   P K +P 
Sbjct: 353  KEPAPTTTKEPAPTTPKEPAPTTTKEP-------APTTTKSAPTTPKEPAPTTPKKPAPT 405

Query: 762  GGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEV--KEPPGLPAKPPASAQP 819
              + P    P     +  +E A   PT        P EP     K+P     K PA   P
Sbjct: 406  TPKEPAPTTPKEPTPTTPKEPA---PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP 462

Query: 820  TDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASS 879
             +     P T +     +P        + A       A     S P + ++ S       
Sbjct: 463  KEPA---PTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEP 519

Query: 880  DSIFHSQGTPNS-FTVVPKLPKE-----AEKDSPLTTEIPNKWGPRLGRDAEGTELSRRH 933
                  +  P +     P  PKE      ++ +P TT+ P    P+        E +   
Sbjct: 520  APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAP-- 577

Query: 934  NWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993
              T P+   P   E++AP+   +  P      +P +P    EE       E  P  P+ +
Sbjct: 578  --TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTP----EEPTPTTPEEPAPTTPKAA 631

Query: 994  --NDPEPPAP 1001
              N P+ PAP
Sbjct: 632  APNTPKEPAP 641


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score =  119 bits (299), Expect = 1e-26
 Identities = 195/819 (23%), Positives = 282/819 (34%), Gaps = 126/819 (15%)

Query: 21   TTPSTSLYATNPPWIFTQEAPEEGTG-GFDGIYYGDNRFNTVSESGTATLKARPRVRPLL 79
            T+  TSL       + T+E          DG     +   T S   T+     P  + L 
Sbjct: 270  TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 329

Query: 80   TFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLI 139
               P       G A+ TP  P     KE   T+        + S+               
Sbjct: 330  KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA--------------- 374

Query: 140  PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPP-----PPVL 194
            P  P  PAP   +     P     P+P +T  P P    EP P  +  P P      P  
Sbjct: 375  PTTPKEPAPTTTKSAPTTPKE---PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 431

Query: 195  EALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP-HTVGTRLFPPG 253
                 P T   P+  TP +  P  P       P  P P    PAP +P     T    P 
Sbjct: 432  PKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 491

Query: 254  GVTKWKSDVALNGRQAEATRASP-PRSPAEPKGSALGPNP----EPHLTFPRSFKVPP-- 306
              T  +         A  T   P P +P EP  +     P    EP  T  +S    P  
Sbjct: 492  PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 551

Query: 307  PTPVRTS----SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDC 362
            P+P  T     + P + A   P+K    T K P+  P  P       ++      P+   
Sbjct: 552  PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA--PTTPKEPAPTTTKKPAPTTPKEPA 609

Query: 363  PGELKATAPASPRLGQSQSQADERAGTPP--PAPPLP----PPAPPLPPPAPPLPPAAPP 416
            P   K TAP +P+   + +  ++ A T P  PAP  P    P  P  P P  P  P AP 
Sbjct: 610  PTTPKETAPTTPK-KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP-APT 667

Query: 417  LPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA-----SSAPVDWRDPSQMEKLR 471
             P A     P      TPK  +P    +P P +P+ TA      +AP   ++P+     +
Sbjct: 668  TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK 727

Query: 472  ---NELAAYLCGSRREDRFLSHRPGPT----VAPQSKEGKKGPRLPEK----------ET 514
                ELA     ++        +P PT     AP + + +  P  P++           T
Sbjct: 728  PAPKELAP--TTTKEPTSTTCDKPAPTTPKGTAPTTPK-EPAPTTPKEPAPTTPKGTAPT 784

Query: 515  LLSLPAKDTPPGVPEKSL------GGSSLTETEAAPSL---TLPSVDYIP---------- 555
             L  PA  TP     K L      G +S T  + AP+    T P+    P          
Sbjct: 785  TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAP 844

Query: 556  --QDSPTPSVRQIRNELEARLSSAAEK---EAKPSIGSLPPKPRLEGGRICENGADDDK- 609
               ++P P+  ++      +  +   K   E+ P + + P    LE     E G    K 
Sbjct: 845  TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP-KEPGVPTTKT 903

Query: 610  --LSKPVAKNLPPQST------TLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPAT 661
               +KP         T      T   TT+  PK     A   + T E  I    T   +T
Sbjct: 904  PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 963

Query: 662  PPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPA 721
              + T    TP K T+  TT    T  P + +T  T+ TT      E+ + P    ++  
Sbjct: 964  TTQDT----TPFKITTLKTT----TLAPKVTTTKKTITTTEIMNKPEETAKP---KDRAT 1012

Query: 722  SQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSP 760
            + + +TP   +    P++A + PT   +      PKT P
Sbjct: 1013 NSKATTPKPQK----PTKAPKKPTSTKK------PKTMP 1041



 Score =  119 bits (298), Expect = 2e-26
 Identities = 176/711 (24%), Positives = 246/711 (34%), Gaps = 121/711 (17%)

Query: 140  PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPP------PSMAPPPPPV 193
            P  P  PAP  P+   EP   +P    P+T  P P    EP P       P+    P P 
Sbjct: 445  PTTPKEPAPTTPK---EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 501

Query: 194  LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP-----APPAPASPHTVGTR 248
                  P T   PS  TP +   PAP     AP     PAP     AP  P  P    T+
Sbjct: 502  TPKEPAPTTTKEPSPTTPKE---PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK 558

Query: 249  LFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT 308
               P   T  +       + A  T   P  +P  PK  A     +P  T P+  +  P T
Sbjct: 559  --EPAPTTPKEPAPTTPKKPAPTTPKEP--APTTPKEPAPTTTKKPAPTTPK--EPAPTT 612

Query: 309  PVRTS-SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPD-RAPEPDCPGEL 366
            P  T+ + P +     P K    T + P+  P  P   + P +   P    PE   P   
Sbjct: 613  PKETAPTTPKKLTPTTPEKLAPTTPEKPA--PTTPE-ELAPTTPEEPTPTTPEEPAPTTP 669

Query: 367  KATAPASPRLGQSQSQADERAGTPP-PAPPLPPPAPPLPP----------PAPPLPPAAP 415
            KA AP +P+     +  +    TP  PAP  P    P  P          PAP  P    
Sbjct: 670  KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPA 729

Query: 416  PLPCAQKAAHPPAGFT------KTPKSSSPALKPKPNP-----PSPENTASSAPVDWRDP 464
            P   A      P   T       TPK ++P    +P P     P+P     +AP   ++P
Sbjct: 730  PKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEP 789

Query: 465  SQMEKLR---NELAAYLCGSRREDRFLSHRPGPTV----APQSKEGKKGPRLPEKETLLS 517
            +     +    ELA     ++      S +P PT     AP + + +  P  P+K     
Sbjct: 790  APTTPKKPAPKELAPTT--TKGPTSTTSDKPAPTTPKETAPTTPK-EPAPTTPKK----- 841

Query: 518  LPAKDTPPGVPEKSLGGSSLTET-----------EAAPSL----TLPSVDYIPQDSPTPS 562
             PA  TP   P  +   S+ T T           E+ P L    T  +++  P++   P+
Sbjct: 842  -PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT 900

Query: 563  VRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKL--SKPVAKNLPP 620
             +          ++A +K  +  + + P           E     +K   SK  A     
Sbjct: 901  TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 960

Query: 621  QSTTLLPTTSLQPKAMLGPAIPPKAT--------------PEPAIPPK--ATLWPATPPK 664
             STT   TT  +   +    + PK T              PE    PK  AT   AT PK
Sbjct: 961  TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPK 1020

Query: 665  ATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQE 724
                P  P KA   PT+  K  + P +    TT PT         +  P  +  +   Q 
Sbjct: 1021 ----PQKPTKAPKKPTSTKKPKTMPRVRKPKTT-PTPRKMTSTMPELNPTSRIAEAMLQT 1075

Query: 725  VSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGG--GEVP-CLYKPH 772
             + P+Q              T  ++     P     GG  GE P  L +PH
Sbjct: 1076 TTRPNQ--------------TPNSKLVEVNPKSEDAGGAEGETPHMLLRPH 1112



 Score =  114 bits (285), Expect = 6e-25
 Identities = 188/762 (24%), Positives = 261/762 (34%), Gaps = 156/762 (20%)

Query: 164 PSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAF 223
           P+P +      P L  P  P    P  P       P  T    +  TP +   PAP    
Sbjct: 331 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKE---PAPTTTK 387

Query: 224 LAPPPPPVPAPAP---PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSP 280
            AP  P  PAP     PAP +P             T  KS        A  T   P  +P
Sbjct: 388 SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP--AP 445

Query: 281 AEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPL 340
             PK  A     EP  T P+  +  P T     + P + A  AP+K    T K P+    
Sbjct: 446 TTPKEPAPTTPKEPTPTTPK--EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA---- 499

Query: 341 PPSFHIRPASQVYPDRAPEPDCPGE-LKATAPASPRLGQSQSQADERAGTPPPAPPLPP- 398
            P+    PA      + P P  P E    T  ++P   +  +    ++    P  P P  
Sbjct: 500 -PTTPKEPAPTT--TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT 556

Query: 399 ---PAPPLPP-PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA 454
              PAP  P  PAP  P    P P   K   P      TPK  +P    KP P +P+  A
Sbjct: 557 TKEPAPTTPKEPAPTTPKK--PAPTTPKEPAPT-----TPKEPAPTTTKKPAPTTPKEPA 609

Query: 455 SSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKET 514
            + P +   P+  +KL                           P + E K  P  PEK  
Sbjct: 610 PTTPKETA-PTTPKKL--------------------------TPTTPE-KLAPTTPEK-- 639

Query: 515 LLSLPAKDTP----PGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL 570
               PA  TP    P  PE+    +  T  E AP+    +    P++ P P+        
Sbjct: 640 ----PAPTTPEELAPTTPEEP---TPTTPEEPAPTTPKAAAPNTPKE-PAPTT------- 684

Query: 571 EARLSSAAEKEAKPSIGSLP-PKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629
                    KE  P+    P P    E       G     L +P             PTT
Sbjct: 685 --------PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA------------PTT 724

Query: 630 SLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGP 689
              PK      + P  T EP         P TP K T  P TP +    PTTP +    P
Sbjct: 725 ---PKKPAPKELAPTTTKEPTSTTCDKPAPTTP-KGT-APTTPKEPA--PTTPKE----P 773

Query: 690 AIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGAR 749
           A  +   T PTT       K+  P   P+KPA +E++ P+  +G  S +     PT    
Sbjct: 774 APTTPKGTAPTTL------KEPAPT-TPKKPAPKELA-PTTTKGPTSTTSDKPAPTTPKE 825

Query: 750 SSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGL 809
           ++   P + +P   + P    P     + S    V  PT  +       EP  + + P  
Sbjct: 826 TAPTTPKEPAPTTPKKPAPTTPETPPPTTSE---VSTPTTTK-------EPTTIHKSPD- 874

Query: 810 PAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLR 869
            + P  SA+PT + L +       E G P     AA               +  +  + +
Sbjct: 875 ESTPELSAEPTPKALENSPK----EPGVPTTKTPAAT--------------KPEMTTTAK 916

Query: 870 DHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTE 911
           D + + +  +        TP + T  PK+ KE    +  TTE
Sbjct: 917 DKTTERDLRT--------TPETTTAAPKMTKETATTTEKTTE 950



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 130/610 (21%), Positives = 200/610 (32%), Gaps = 60/610 (9%)

Query: 415  PPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNEL 474
            P  P + K A PP+G ++T KS++   K  P PP+ + T      +            E 
Sbjct: 110  PTSPPSSKKAPPPSGASQTIKSTT---KRSPKPPNKKKTKKVIESEEITEEHSVSENQES 166

Query: 475  AAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLG- 533
            ++    S         +     A   +  KK      K+          PP V E   G 
Sbjct: 167  SSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGL 226

Query: 534  --------GSSLTETEAAPSLTLPSVDYIPQDSPTPSV---RQIRNELEARLSSAAEKEA 582
                        + T+     T P +      +P PS+        E    ++     E 
Sbjct: 227  DNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVET 286

Query: 583  KPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIP 642
            K +  +   +   +G     +  +   + K  AK+L P S  L   T        GPA+ 
Sbjct: 287  KETT-TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALT 345

Query: 643  PKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTT 702
                P P  P +       P   T    TP    S PTTP +    PA  +T  + PTT 
Sbjct: 346  TPKEPTPTTPKE-------PASTTPKEPTPTTIKSAPTTPKE----PA-PTTTKSAPTTP 393

Query: 703  SQLMAEKDSGPA-GQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPG 761
             +        PA   P++PA      P       +P+     PT     +   P K +P 
Sbjct: 394  KEPAPTTTKEPAPTTPKEPAPTTTKEP-------APTTTKSAPTTPKEPAPTTPKKPAPT 446

Query: 762  GGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEV--KEPPGLPAKPPASAQP 819
              + P    P     +  +E A   PT        P EP     K+P     K PA   P
Sbjct: 447  TPKEPAPTTPKEPTPTTPKEPA---PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP 503

Query: 820  TDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASS 879
             +     P T +     +P        + A       A     S P + ++ S       
Sbjct: 504  KEPA---PTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEP 560

Query: 880  DSIFHSQGTPNS-FTVVPKLPKE-----AEKDSPLTTEIPNKWGPRLGRDAEGTELSRRH 933
                  +  P +     P  PKE      ++ +P TT+ P    P+        E +   
Sbjct: 561  APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAP-- 618

Query: 934  NWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993
              T P+   P   E++AP+   +  P      +P +P    EE       E  P  P+ +
Sbjct: 619  --TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTP----EEPTPTTPEEPAPTTPKAA 672

Query: 994  --NDPEPPAP 1001
              N P+ PAP
Sbjct: 673  APNTPKEPAP 682


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score =  110 bits (274), Expect = 1e-23
 Identities = 110/356 (30%), Positives = 134/356 (37%), Gaps = 42/356 (11%)

Query: 130 PGQYGQDLLIPPPPPGPAPGPP-QDISEPPGGSPLPSPPSTAPP---------PPPLLLE 179
           P Q G     PP PPG   GPP Q  ++P G  P P  P   PP         PPP   +
Sbjct: 40  PPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ 99

Query: 180 PPPPP---SMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPP--PPPVPAP 234
            PPP    S +P  PP      PP   + P  P PP   P  PP      P  PPP   P
Sbjct: 100 GPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKP 159

Query: 235 APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSA-LGPNPE 293
             P P   +   +   PPG   K +      G Q +     PP  P +P+G    G N  
Sbjct: 160 QGPPPQGDNKSRSSRSPPG---KPQGPPPQGGNQPQG----PPPPPGKPQGPPPQGGNKP 212

Query: 294 PHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKA---PSRLPLPPSFHIRPAS 350
                P   + PPP     S    Q A+  P K +G   +    P   P PP     P  
Sbjct: 213 QGPPPPGKPQGPPPQGDNKS----QSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP 268

Query: 351 QV--YPDRAPEPDCP------GELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPP 402
           Q    P   P P  P      G  K+ +  SP  G+ Q    +  G  P  PP PP  P 
Sbjct: 269 QGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPP-GKPQGPPPQ-GGNQPQGPPPPPGKPQ 326

Query: 403 LPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAP 458
            PPP     P  PP P  +    PP G +K+  + SP  KP+  PP  E      P
Sbjct: 327 GPPPQGGNKPQGPP-PPGKPQGPPPQGGSKSRSARSPPGKPQ-GPPQQEGNNPQGP 380



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 92/318 (28%), Positives = 119/318 (37%), Gaps = 30/318 (9%)

Query: 152 QDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTP 211
           +D+S+    S +   P  APP      + PP P   P  P       PP   + P  P P
Sbjct: 21  EDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGP-------PPQGGNQPQGPPP 73

Query: 212 PDFIPPAPPLAFLAPP--PPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQA 269
           P   P  PP      P  PPP   P  P P    +   R  PPG   K +      G Q 
Sbjct: 74  PPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPR-SPPG---KPQGPPPQGGNQP 129

Query: 270 EATRASPPRSPAEPKG-SALGPNPEPHLTFPRSFKVPPP---TPVRTSSIPVQEAQEAPR 325
           +     PP  P +P+G    G N       P   + PPP      R+S  P  + Q  P 
Sbjct: 130 Q----GPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQ-GPP 184

Query: 326 KEEGATKKAPSRLP-----LPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQ 380
            + G   + P   P      PP    +P     P +   P   G+ K+ +  SP  G+ Q
Sbjct: 185 PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPP-GKPQ 243

Query: 381 SQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPA 440
               +  G  P  PP PP  P  PPP     P  PP P  +    PP G +K+  S SP 
Sbjct: 244 GPPPQ-GGNQPQGPPPPPGKPQGPPPQGGNKPQGPP-PPGKPQGPPPQGGSKSRSSRSPP 301

Query: 441 LKPKPNPPSPENTASSAP 458
            KP+  PP   N     P
Sbjct: 302 GKPQGPPPQGGNQPQGPP 319



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 104/450 (23%), Positives = 144/450 (32%), Gaps = 61/450 (13%)

Query: 318 QEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLG 377
           Q   E   +EE  +  A +    PP    +P     P   P+   P          P  G
Sbjct: 17  QNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPG 76

Query: 378 QSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSS 437
           + Q    +    P   PP   P  P P       P +PP    +    PP G  +     
Sbjct: 77  KPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPP---GKPQGPPPQGGNQPQGPP 133

Query: 438 SPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRP-GPTV 496
            P  KP+  PP   N     P   +      +  N+         R  R    +P GP  
Sbjct: 134 PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNK--------SRSSRSPPGKPQGP-- 183

Query: 497 APQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQ 556
            PQ     +GP  P        P K  P G P +  GG+   + +  P    P       
Sbjct: 184 PPQGGNQPQGPPPP--------PGK--PQGPPPQ--GGN---KPQGPPPPGKPQGPPPQG 228

Query: 557 DSPTPSVRQIRNELEARLSSAA-EKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVA 615
           D+ + S R    + +        + +  P     P  P  +GG   +      K   P  
Sbjct: 229 DNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP-- 286

Query: 616 KNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKA 675
              PPQ  +   ++   P    GP  PP+   +P  PP     P  PP    G   P   
Sbjct: 287 ---PPQGGSKSRSSRSPPGKPQGP--PPQGGNQPQGPPPPPGKPQGPPPQ--GGNKP--- 336

Query: 676 TSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEG 735
             GP  P K    P         P   S+  + +   P G+P+ P  QE + P     +G
Sbjct: 337 -QGPPPPGKPQGPP---------PQGGSKSRSAR--SPPGKPQGPPQQEGNNP-----QG 379

Query: 736 SPSEATRLPTQGARSSAAFP--PKTSPGGG 763
            P  A   P Q     A  P  P   P GG
Sbjct: 380 PPPPAGGNPQQPQAPPAGQPQGPPRPPQGG 409



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 107/462 (23%), Positives = 143/462 (30%), Gaps = 94/462 (20%)

Query: 373 SPRLGQSQSQ-ADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFT 431
           SP L     Q A  + G  P  PP PP  P  PPP     P  PP         PP G  
Sbjct: 28  SPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPP---------PPPG-- 76

Query: 432 KTPKSSSPALKPKPNPPSPENTASSAPVDWR---DPSQMEKLRNELAAYLCGSRREDRFL 488
                     KP+  PP   N     P   +    P Q +K R+  +             
Sbjct: 77  ----------KPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSP------------ 114

Query: 489 SHRPGPTVAPQSKEGK--KGPRLPEKETLLSLPA---KDTPPGVPEKSLGGSSLTETEAA 543
              PG    P  + G   +GP  P  +     P    K   P  P K  G     + ++ 
Sbjct: 115 ---PGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSR 171

Query: 544 PSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICEN 603
            S + P     PQ  P     Q               +  P     P  P  +GG   + 
Sbjct: 172 SSRSPPGK---PQGPPPQGGNQ--------------PQGPPPPPGKPQGPPPQGGNKPQG 214

Query: 604 GADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPP 663
                K   P     PPQ      +    P    GP  PP+   +P  PP     P  PP
Sbjct: 215 PPPPGKPQGP-----PPQGDNKSQSARSPPGKPQGP--PPQGGNQPQGPPPPPGKPQGPP 267

Query: 664 ----KATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEK 719
                   GP  P K   GP  P +  S    + +    P         +  GP   P K
Sbjct: 268 PQGGNKPQGPPPPGK-PQGP--PPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGK 324

Query: 720 PASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLS 779
           P        ++ +G   P +    P QG   S +   ++ PG  + P   + +  Q    
Sbjct: 325 PQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRS--ARSPPGKPQGPPQQEGNNPQGP-- 380

Query: 780 REVAVVMPTLARGGAAGP-----GEPVEVKEPP--GLPAKPP 814
                  P  A G    P     G+P     PP  G P++PP
Sbjct: 381 -------PPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPP 415



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 44/173 (25%), Positives = 62/173 (35%), Gaps = 20/173 (11%)

Query: 953  NLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSP 1012
            N PQG P P     PP   + + +       +   PPP+  N P+ P P     G+   P
Sbjct: 210  NKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPP---GKPQGP 266

Query: 1013 PRNNYSDLRQLPNAG-PGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEP 1071
            P    +  +  P  G P  PP  G S+  +     G        GG +           P
Sbjct: 267  PPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQ--------GP 318

Query: 1072 HRGPGLPHGGTGRSLSSPNCFGPQPGG------PEMRRVNSAGRAPPGGLHAP 1118
               PG P G   +  + P   GP P G      P+    + + R+PPG    P
Sbjct: 319  PPPPGKPQGPPPQGGNKPQ--GPPPPGKPQGPPPQGGSKSRSARSPPGKPQGP 369



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 99/423 (23%), Positives = 126/423 (29%), Gaps = 85/423 (20%)

Query: 619  PPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPP----KATLGPATPLK 674
            PPQ           P    GP  PP+   +P  PP     P  PP        GP  P K
Sbjct: 40   PPQGGNKPQGPPSPPGKPQGP--PPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGK 97

Query: 675  ATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGE 734
                P    K+ S P         P        +    P G+P+ P  Q  + P   +G 
Sbjct: 98   PQGPPPQGDKSRS-PRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKP---QGP 153

Query: 735  GSPSEATRLPTQG---ARSSAAFPPKTS---PGGGEVPCLYKPHCHQSSLSREVAVVMPT 788
              P +    P QG   +RSS + P K     P GG  P    P               P 
Sbjct: 154  PPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPP--------------PG 199

Query: 789  LARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHP--------------VTGEVVE 834
              +G     G   +   PPG P  PP       +  R P                G    
Sbjct: 200  KPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPP 259

Query: 835  RGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTV 894
             G P         + Q     G   G     GS      ++ +S       QG P     
Sbjct: 260  PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGS------KSRSSRSPPGKPQGPPPQGGN 313

Query: 895  VPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNL 954
             P+ P             P   G   G   +G            +PQ P       P   
Sbjct: 314  QPQGP-------------PPPPGKPQGPPPQGGN----------KPQGP------PPPGK 344

Query: 955  PQGHPL---PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSS 1011
            PQG P     KS S+   P   +   ++E N    PPPP   N  +P AP     G+   
Sbjct: 345  PQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPP---AGQPQG 401

Query: 1012 PPR 1014
            PPR
Sbjct: 402  PPR 404



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 43/174 (24%), Positives = 59/174 (33%), Gaps = 22/174 (12%)

Query: 953  NLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPE--PPAPALQYLGRQS 1010
            N PQG P P     PP   + +         +   PPP+  N P+  PP P       Q 
Sbjct: 148  NKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKP----QG 203

Query: 1011 SPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGE 1070
             PP+         P   P  PP  G ++  +     G        GG +           
Sbjct: 204  PPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQP--------QG 255

Query: 1071 PHRGPGLPHGGTGRSLSSPNCFGPQPGG------PEMRRVNSAGRAPPGGLHAP 1118
            P   PG P G   +  + P   GP P G      P+    + + R+PPG    P
Sbjct: 256  PPPPPGKPQGPPPQGGNKPQ--GPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGP 307



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 98/421 (23%), Positives = 127/421 (30%), Gaps = 72/421 (17%)

Query: 709  KDSGPAGQPEKPASQEVSTPSQARGEGSP-SEATRLPTQGARSSAAFPPKTSPGGGEVPC 767
            K  GP   P KP        +Q +G   P  +    P QG       PP   P G     
Sbjct: 46   KPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPP-- 103

Query: 768  LYKPHCHQSSLSREVAVVMPTLARGGAAGP-----GEPVEVKEPPGLPAKPPASAQPTDE 822
                   Q   SR      P    G   GP      +P     PPG P  PP   Q  ++
Sbjct: 104  -------QGDKSRS-----PRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP--QGGNK 149

Query: 823  LLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSI 882
                P  G+   +G P        Q   K RS  +  G+   P       +Q +      
Sbjct: 150  PQGPPPPGK--PQGPPP-------QGDNKSRSSRSPPGKPQGPPP--QGGNQPQGPPPPP 198

Query: 883  FHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKW-------GPRLGRDAEGTELSRRHNW 935
               QG P      P+ P    K      +  NK        G   G   +G    +    
Sbjct: 199  GKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPP 258

Query: 936  TKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSND 995
               +PQ P         N PQG P P     PP     +         +   PPP+  N 
Sbjct: 259  PPGKPQGPPP----QGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQ 314

Query: 996  PE--PPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLER 1053
            P+  PP P       Q  PP+         P   P  PP  G S+  +     G     +
Sbjct: 315  PQGPPPPPGKP----QGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPG-----K 365

Query: 1054 FSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPG 1113
              G  +         G   +GP  P GG  +   +P     QP GP         R P G
Sbjct: 366  PQGPPQQ-------EGNNPQGPPPPAGGNPQQPQAPP--AGQPQGPP--------RPPQG 408

Query: 1114 G 1114
            G
Sbjct: 409  G 409



 Score = 37.7 bits (86), Expect = 0.066
 Identities = 52/214 (24%), Positives = 67/214 (31%), Gaps = 38/214 (17%)

Query: 953  NLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSP 1012
            N PQG P P     PP P   +         +   PPP+  N P+ P P     G+   P
Sbjct: 87   NKPQGPPPPGKPQGPP-PQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPP---GKPQGP 142

Query: 1013 PRNNYSDLRQLPNAG-PGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEP 1071
            P    +  +  P  G P  PP  G ++                S   RS           
Sbjct: 143  PPQGGNKPQGPPPPGKPQGPPPQGDNK----------------SRSSRS----------- 175

Query: 1072 HRGPGLPHGGTGRSLSSPNCFGPQPG---GPEMRRVNSA-GRAPPGGLHAPRLSLEGAAR 1127
               PG P G   +  + P    P PG   GP  +  N   G  PPG    P    +  ++
Sbjct: 176  --PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQ 233

Query: 1128 GAAEAKHKAPGSADYGFAPAAGRSPYTTTRYGSP 1161
             A     K  G    G     G  P      G P
Sbjct: 234  SARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP 267



 Score = 37.7 bits (86), Expect = 0.066
 Identities = 26/87 (29%), Positives = 30/87 (34%), Gaps = 4/87 (4%)

Query: 130 PGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPS---- 185
           P Q G     PPPP  P   PPQ  S+       P  P   P       + PPPP+    
Sbjct: 329 PPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNP 388

Query: 186 MAPPPPPVLEALSPPHTLSSPSIPTPP 212
             P  PP  +   PP          PP
Sbjct: 389 QQPQAPPAGQPQGPPRPPQGGRPSRPP 415



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 52/212 (24%), Positives = 65/212 (30%), Gaps = 52/212 (24%)

Query: 955  PQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPR 1014
            PQG   P+    PPSP  K +            PPP+  N P+ P P     G+   PP 
Sbjct: 41   PQGGNKPQG---PPSPPGKPQG-----------PPPQGGNQPQGPPPPP---GKPQGPPP 83

Query: 1015 NNYSDLRQLPNAG-PGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHR 1073
               +  +  P  G P  PP  G                           K R     P  
Sbjct: 84   QGGNKPQGPPPPGKPQGPPPQGD--------------------------KSR----SPRS 113

Query: 1074 GPGLPHGGTGRSLSSPNCFGPQPG---GPEMRRVNSA-GRAPPGGLHAPRLSLEGAARGA 1129
             PG P G   +  + P    P PG   GP  +  N   G  PPG    P    +  +R +
Sbjct: 114  PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSS 173

Query: 1130 AEAKHKAPGSADYGFAPAAGRSPYTTTRYGSP 1161
                 K  G    G     G  P      G P
Sbjct: 174  RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP 205


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  108 bits (271), Expect = 2e-23
 Identities = 173/686 (25%), Positives = 248/686 (36%), Gaps = 113/686 (16%)

Query: 138   LIPPPPPG----PAPGPPQDISEPPGGSPL------PSPPSTAPPPPPLLLEP------- 180
             +IPP  P     P   PP  + E P    +      P  P   P   P +L P       
Sbjct: 10449 IIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEK 10508

Query: 181   --PPPPSMAP--PPPPVLEALSPPHTLSSPSIPTPPDFIPPAPP-----LAFLAPPPPPV 231
               P PP+  P  PPP V EA  P   +    +P PP   P  PP     +   A P   V
Sbjct: 10509 KVPVPPAKKPEAPPPKVPEA--PKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKV 10566

Query: 232   PAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAE--------- 282
             P   PP P SP         P  V   K   A   ++ E T    P +P E         
Sbjct: 10567 PEAIPPKPESPPPEVPE--APKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPV 10624

Query: 283   --PKGSALGPN--PE-PHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSR 337
               PK   + P   PE P +  P   KVP   P +  S P +  +E    EE A ++ P+ 
Sbjct: 10625 PPPKKPEVPPTKVPEVPKVAVPEK-KVPEAIPPKPESPPPEVFEE---PEEVALEEPPAE 10680

Query: 338   LPLPPSFHIRPASQVYPDR-APEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPL 396
             +   P     P   V P +  PE   P    A     P L   +     +   P    PL
Sbjct: 10681 VVEEPEPAAPPQVTVPPKKPVPEKKAP----AVVAKKPELPPVKVPEVPKEVVPEKKVPL 10736

Query: 397   PPPAPPLPPPA--PPLPPAAPP---LPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPE 451
               P  P  PPA  P +P    P   +   +K   PPA   + PK   P L+ KP  P PE
Sbjct: 10737 VVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPK--KPVLEEKPAVPVPE 10794

Query: 452   NTASSAPVDWRDPSQM---EKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKE---GKK 505
                S  P  + +P ++   E++  E    +  +  E+      P P V  + K+    KK
Sbjct: 10795 RAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEE---PEVPPPAVPEEPKKIIPEKK 10851

Query: 506   ----------GPRLPEKETLLS----LPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSV 551
                        P+ PE E ++      P    PP  P K      + + +A P   +P  
Sbjct: 10852 VPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEK 10911

Query: 552   DYIPQD-SPTP-----SVRQIRNELEARLSSAAEKEAKPSIGSLPP---KPRLEGGRICE 602
               +P+    TP       +++R  L  R     E+    S+    P   +P++E  ++  
Sbjct: 10912 PQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKL-- 10969

Query: 603   NGADDDKLSKPVAKNLPPQ---STTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWP 659
                  +K+ KP     PP        +PT + + + +  P   P+   +PAIP  A   P
Sbjct: 10970 -----EKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEI--KPAIPLPAP-EP 11021

Query: 660   ATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGP-AGQPE 718
                P+A +    P      PT      + P +   A        +  A K  GP  G P+
Sbjct: 11022 KPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKA---EAKAPKEEAAKPKGPIKGVPK 11078

Query: 719   KPASQEVSTPSQAR----GEGSPSEA 740
             K  S   +   + R    GE  P EA
Sbjct: 11079 KTPSPIEAERRKLRPGSGGEKPPDEA 11104



 Score =  106 bits (264), Expect = 2e-22
 Identities = 184/744 (24%), Positives = 256/744 (34%), Gaps = 125/744 (16%)

Query: 157   PPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAP--------------------PPPPVLEA 196
             PP G  +         PP  ++    PP+  P                    PP  V E 
Sbjct: 10439 PPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEV 10498

Query: 197   LSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVP---APAPPAPASPHTVGTRL--FP 251
             L P   +    +P PP   P APP      P   VP    P PP P  P    T++   P
Sbjct: 10499 LPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPP-PKKPEVPPTKVPEVP 10557

Query: 252   PGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVR 311
                V + K   A+  +      + PP  P  PK       PE         KVP   P +
Sbjct: 10558 KAAVPEKKVPEAIPPK----PESPPPEVPEAPKEVV----PEK--------KVPAAPPKK 10601

Query: 312   TSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAP 371
                 PV +  EAP KE    KK P   P  P        +V     PE   P E     P
Sbjct: 10602 PEVTPV-KVPEAP-KEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVP-EAIPPKP 10658

Query: 372   ASPRLGQSQSQADERAGTPPPAPPLPPPAPPLP-----PPAPPLPPAAPPLPCAQKAAHP 426
              SP   +   + +E A   PPA  +  P P  P     PP  P+P    P   A+K   P
Sbjct: 10659 ESPP-PEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELP 10717

Query: 427   PAGFTKTPKSSSPALK-PKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRRED 485
             P    + PK   P  K P   P  PE     AP     P+++ ++  E+          +
Sbjct: 10718 PVKVPEVPKEVVPEKKVPLVVPKKPE-----AP-----PAKVPEVPKEVV--------PE 10759

Query: 486   RFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLP-------AKDTPPGV---PEKSLGGS 535
             + ++    P V P      K P +P+K  L   P       A+  PP V   PE+     
Sbjct: 10760 KKVAVPKKPEVPP-----AKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEE 10814

Query: 536   SLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL--EARLSSAAEKEAKPSIGSLPPKP 593
              +   E  P   +P  +    + P P+V +   ++  E ++    + EA P     P +P
Sbjct: 10815 EIAPEEEKP---VPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPP-----PKEP 10866

Query: 594   RLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE-PAIP 652
               E             + KP  K  PP      P   ++ K     AIP K  PE P +P
Sbjct: 10867 EPE-----------KVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVP 10915

Query: 653   PKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLM------ 706
              K  L   TP K   G     K    P    +      + S     P      +      
Sbjct: 10916 EKVEL---TPLKVPGGEKKVRKLL--PERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLE 10970

Query: 707   -AEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLP-TQGARSSAAFPPKTSPGGGE 764
               +K + P   P KP  +EV  P+  + E    E T++P  + A    A  PK  P   E
Sbjct: 10971 KVKKPAVPEPPPPKPV-EEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKP-EAE 11028

Query: 765   VPCLYKPHCHQSSLSREVAVVMPTLA-RGGAAGPGEPVEVKEPP--GLPAKPPASAQPTD 821
             V  +  P            V +P +  +  A  P E     + P  G+P K P+  +   
Sbjct: 11029 VKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAER 11088

Query: 822   ELLRHPVTGEVVERGSPMALLLAA 845
               LR    GE     +P    L A
Sbjct: 11089 RKLRPGSGGEKPPDEAPFTYQLKA 11112



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 207/942 (21%), Positives = 303/942 (32%), Gaps = 175/942 (18%)

Query: 137   LLIPP---PPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPP--PLLLEPPPPPSMAPPPP 191
             +LIP    PPP   P  P+    P    P+P P     PP   P + + P P    P P 
Sbjct: 9991  VLIPKKEKPPPAKVPEVPKK-PVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPA 10049

Query: 192   PVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPP------PVPAPAPPAPASPHTV 245
             P      P      P    P +  P   P    APPP       PVP P           
Sbjct: 10050 PKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLF 10109

Query: 246   GTRLFPPGGVTKWKSDVALNGRQA--EATRASPPRSPAEPKGSALGPN-----------P 292
                + P   V   + +V     +   E     P      P+   + P            P
Sbjct: 10110 EEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVP 10169

Query: 293   EPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA-PRKEEGATKKAPS--------RLPLPPS 343
             E  +      KVP P PV      V E +   P+KEE    K P         R+ LP  
Sbjct: 10170 EEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKE 10229

Query: 344   FHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPL 403
               + P  +V  +   EP    E+    P       S  + +E A  PP  P +   A P 
Sbjct: 10230 EEVLPV-EVTEEPEEEPISEEEIPEEPP-------SIEEVEEVA--PPRVPEVIKKAVPE 10279

Query: 404   PPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRD 463
              P   P    APP   ++K            K + PA  P+     PE       V  ++
Sbjct: 10280 APTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPE---KKVLVPKKE 10336

Query: 464   PSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDT 523
                  K R  L   +  + R++  +  R    V     E      +PE+E    +     
Sbjct: 10337 AVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVE-----EIPEEEEFHEV----- 10386

Query: 524   PPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAK 583
                  E+        E E    L    V+   ++     V ++    EA      EK   
Sbjct: 10387 -----EEYFEEGEFHEVEEFIKLEQHRVE---EEHRVEKVHRVIEVFEAEEVEVFEKPKA 10438

Query: 584   PSIGS------LPPK-----------PRLEGGRICENGADDDKLSKPVAKNLPPQST-TL 625
             P  G       +PPK           P  +   + +    ++K+  P    +PP     +
Sbjct: 10439 PPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEV 10498

Query: 626   LPTTSLQP--KAMLGPAIPPKATPEPAIP--PKATL----WPATPPKATLGPATPLKATS 677
             LP   + P  K  + PA  P+A P P +P  PK  +     P  PPK    P T +    
Sbjct: 10499 LPPKEVVPEKKVPVPPAKKPEA-PPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVP 10557

Query: 678   GPTTPLKATS---GPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGE 734
                 P K       P   S    +P    +++ EK   PA  P+KP    V  P +A  E
Sbjct: 10558 KAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEK-KVPAAPPKKPEVTPVKVP-EAPKE 10615

Query: 735   GSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGA 794
               P +   +P          PPK      EVP    P         EV  V         
Sbjct: 10616 VVPEKKVPVP----------PPKKP----EVPPTKVP---------EVPKV--------- 10643

Query: 795   AGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA---LLLAARQRAQK 851
             A P + V    PP   + PP   +  +E+       EVVE   P A   + +  ++   +
Sbjct: 10644 AVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPE 10703

Query: 852   GRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTE 911
              ++      +  LP                             VP++PKE   +  +   
Sbjct: 10704 KKAPAVVAKKPELPP--------------------------VKVPEVPKEVVPEKKVPLV 10737

Query: 912   IPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWE-RVAPSNLPQGHPLPKSFSSPPSP 970
             +P K       +A   ++        PE +  V  +  V P+ +P+    P     P  P
Sbjct: 10738 VPKK------PEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVP 10791

Query: 971   SNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSP 1012
               +R E           PPPE   +PE  AP  +    +  P
Sbjct: 10792 VPERAES----------PPPEVYEEPEEIAPEEEIAPEEEKP 10823



 Score = 73.9 bits (180), Expect = 8e-13
 Identities = 136/634 (21%), Positives = 217/634 (34%), Gaps = 108/634 (17%)

Query: 139   IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALS 198
             + P P  P P  P+  + P        P    P P P  L+PPPP     P     E + 
Sbjct: 9795  VKPVPEEPVPTKPK--APPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIR 9852

Query: 199   PPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKW 258
                T       T P    P  P   +A    PVP      P     V   L P       
Sbjct: 9853  ISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEP------- 9905

Query: 259   KSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQ 318
               +VA      E           E +   +    E    F    +V P  PV+   +P +
Sbjct: 9906  -EEVAFE----EEVVTHVEEYLVEEEEEYIHEEEE----FITEEEVVPVIPVKVPEVPRK 9956

Query: 319   EAQE------APRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPA 372
                E       P+K+E      P+++P  P    +P  +V P   P+ + P   K   P 
Sbjct: 9957  PVPEEKKPVPVPKKKEA----PPAKVPEVPK---KPEEKV-PVLIPKKEKPPPAK--VPE 10006

Query: 373   SPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTK 432
              P+    +   +E+   P P     PPA     P  P+P    P+P  +K   PPA   +
Sbjct: 10007 VPK----KPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPE 10062

Query: 433   TPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHR- 491
              PK     L P+   P+P      AP     P ++ K R  +   +   + E+       
Sbjct: 10063 VPKK----LIPEEKKPTPVPKKVEAP-----PPKVPKKREPVPVPVALPQEEEVLFEEEI 10113

Query: 492   -PGPTVAPQSKE--GKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTL 548
              P   V P+ +E   ++   LPE+E +L    ++ PP             E E  P    
Sbjct: 10114 VPEEEVLPEEEEVLPEEEEVLPEEEEVLP-EEEEIPP-------------EEEEVP---- 10155

Query: 549   PSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDD 608
             P  +Y+P++       ++              E KP +    P P +      +    + 
Sbjct: 10156 PEEEYVPEEEEFVPEEEVL------------PEVKPKVPVPAPVPEI------KKKVTEK 10197

Query: 609   KLSKPVAKNLPPQSTTLLPTTSLQPKAMLGP----AIPPKATPEPAIPP-KATLWPATPP 663
             K+  P  +  PP     +P   ++ K ++ P     +P + T EP   P      P  PP
Sbjct: 10198 KVVIPKKEEAPPAKVPEVP-KKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPP 10256

Query: 664   KATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQ 723
                      ++  + P  P       A+    T +P        + ++ PA   +K   +
Sbjct: 10257 S-----IEEVEEVAPPRVP--EVIKKAVPEAPTPVP-------KKVEAPPAKVSKKIPEE 10302

Query: 724   EVSTPSQARGEGSPSEATRLPTQGARSSAAFPPK 757
             +V  P Q + E  P++   +P +        P K
Sbjct: 10303 KVPVPVQKK-EAPPAKVPEVPKKVPEKKVLVPKK 10335



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 84/343 (24%), Positives = 118/343 (34%), Gaps = 50/343 (14%)

Query: 137   LLIPPPPPGPAPGPPQDISE--PPGGSPLPSPPSTAP------PPPPLLLEPP--PPPSM 186
             L++P  P  P    P+   E  P     +P  P   P      P  P+L E P  P P  
Sbjct: 10736 LVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPER 10795

Query: 187   APPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVG 246
             A  PPP  E    P  + +P     P+   P P      P  PP   P  P    P    
Sbjct: 10796 AESPPP--EVYEEPEEI-APEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKV 10852

Query: 247   TRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPP 306
               +  P                     A PP+ P EP+     P  +P    P     PP
Sbjct: 10853 PVIKKP--------------------EAPPPKEP-EPEKVIEKPKLKPRPPPP-----PP 10886

Query: 307   PTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP---SFHIRPASQVYPDRAPEPDCP 363
               P       + + +  P+K+     + P ++ L P       +   ++ P+R PEP   
Sbjct: 10887 APPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEE 10946

Query: 364   GELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLP-------PAAPP 416
               LK+     P   + + +  +      PA P PPP  P+     P         P    
Sbjct: 10947 VVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTK 11006

Query: 417   LPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPV 459
             +P  + A   PA   K PK  +     KP P  PE T  +APV
Sbjct: 11007 VPEIKPAIPLPAPEPK-PKPEAEVKTIKPPPVEPEPTPIAAPV 11048



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 122/608 (20%), Positives = 192/608 (31%), Gaps = 104/608 (17%)

Query: 139   IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALS 198
             I  PPP   P  P+ I  P    P P P     PPP +  EP  P      PP V++   
Sbjct: 9572  IEEPPPAKVPEAPKKIV-PEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEE 9630

Query: 199   PPHTLSSPSIPTPPDFIPPAPPLAFLA----PPPPPVPAPAPPAPASPHTVGTRLFP--- 251
             P      P+  T             +A      PP    P  P  A P     +L P   
Sbjct: 9631  P-----LPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKRE 9685

Query: 252   ---PGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT 308
                P  VT+++  V    ++ + +  +P R P   K   +    E   T           
Sbjct: 9686  EEPPAKVTEFRKRVV---KEEKVSIEAPKREPQPIKEVTIMEEKERAYT----------- 9731

Query: 309   PVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKA 368
              +   ++ VQ  +E    EE   K+     P           + Y +R  E         
Sbjct: 9732  -LEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQY----EEYEEREYE--------- 9777

Query: 369   TAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPA 428
                   R  + +    E        P  P P  P+P    P  P APP    +KA     
Sbjct: 9778  ------RYEEHEEYITE--------PEKPIPVKPVPEEPVPTKPKAPPAKVLKKA----- 9818

Query: 429   GFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFL 488
                  P+   P   PK   P P             P + +K+  E        R +++  
Sbjct: 9819  ----VPEEKVPVPIPKKLKPPPPKV----------PEEPKKVFEEKIRISITKREKEQVT 9864

Query: 489   SHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTL 548
                    + P+    ++   +P KE    +   + P  +  + +       T     L  
Sbjct: 9865  EPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVE 9924

Query: 549   PSVDYIPQDSPTPSVRQIRNELEARLSSAAEK----EAKPSIGSLPPKPRLEGGRICENG 604
                +YI ++    +  ++   +  ++     K    E KP    +P K      ++ E  
Sbjct: 9925  EEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPV--PVPKKKEAPPAKVPE-- 9980

Query: 605   ADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIP-PKATLWPATPP 663
                      V K    +   L+P     P A + P +P K  PE  +P P      A P 
Sbjct: 9981  ---------VPKKPEEKVPVLIPKKEKPPPAKV-PEVPKKPVPEEKVPVPVPKKVEAPPA 10030

Query: 664   KATLGPATPLKATSGPT-TPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPAS 722
             K    P  P+     P   P K  + PA       +P    +L+ E +  P   P+K  +
Sbjct: 10031 KVPEVPKKPVPEKKVPVPAPKKVEAPPA------KVPEVPKKLIPE-EKKPTPVPKKVEA 10083

Query: 723   QEVSTPSQ 730
                  P +
Sbjct: 10084 PPPKVPKK 10091



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 98/433 (22%), Positives = 144/433 (33%), Gaps = 75/433 (17%)

Query: 140  PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPP--PLLLEPPPPPSMAPPPPPVLEAL 197
            PPP     P  P     P   +P+P P    PP P  P + + P P    P P P  E  
Sbjct: 9284 PPPKVPELPEKPA----PEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPA 9339

Query: 198  SPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVP-----------------APAPPAPA 240
            +PP     P  P P + I P P       PP  VP                     P PA
Sbjct: 9340 APPKVPEVPKKPVPEEKI-PVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPA 9398

Query: 241  SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300
             P        P   V + +  V     + E     PP+ PA PK     P  +  +  P 
Sbjct: 9399 VPE------IPKKKVPEERKPVP----RKEEEVPPPPKVPALPKKPV--PEEKVAVPVPV 9446

Query: 301  SFKVPPPTPVRTSSIPVQE----AQE-----APRKEEGATKKAPSRLPLPPSFHIRPAS- 350
            + K PPP    +    V+E    A+E      P++ E    +  +      S      S 
Sbjct: 9447 AKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSI 9506

Query: 351  QVYPDRAPEPDCPGEL---------------KATAPASPRLGQSQSQADERAGTPPPAPP 395
             VY +   E +   E+               +     S R+    ++  ER        P
Sbjct: 9507 SVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKP 9566

Query: 396  LPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTAS 455
              P     PPPA    P AP     +K    PA   K  K   P +  +P  P PE    
Sbjct: 9567 KIPAKIEEPPPAK--VPEAPKKIVPEKKV--PAPVPKKEKVPPPKVPEEPKKPVPEKKVP 9622

Query: 456  SAPVDWRDPSQMEKLRNELAAYLCGSRREDRFL---SHRPGPTVAPQSKEGKKGPRLPEK 512
               +   +P   +     +        +E++ L   + +  P  A   +E K+   +PE+
Sbjct: 9623 PKVIKMEEPLPAKVTERHMQI-----TQEEKVLVAVTKKEAPPKARVPEEPKRA--VPEE 9675

Query: 513  ETLLSLPAKDTPP 525
            + L   P ++  P
Sbjct: 9676 KVLKLKPKREEEP 9688



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 93/414 (22%), Positives = 137/414 (33%), Gaps = 72/414 (17%)

Query: 255  VTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSS 314
            VT+ K  VA++ R        PP+ P  P+     P PE     P   KV PP P     
Sbjct: 9269 VTEEKIHVAISKRVEP-----PPKVPELPEK----PAPEEVAPVPIPKKVEPPAP----- 9314

Query: 315  IPVQEAQEAPRKEEGATKKAPSRLPL-PPSFHIRPASQVYPDRAPEPDCPGELKATAPAS 373
              V E  + P  EE      P + P  PP     P   V  ++ P P    + K   PA 
Sbjct: 9315 -KVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVP--VAKKKEAPPAK 9371

Query: 374  PRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKT 433
                Q     +E+          PPPA P   P   +P    P+P  ++   PP      
Sbjct: 9372 VPEVQKGVVTEEKITIVTQREESPPPAVP-EIPKKKVPEERKPVPRKEEEVPPPPKVPAL 9430

Query: 434  PKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPG 493
            PK      KP P     E  A   PV  + P    ++  +          E RF++    
Sbjct: 9431 PK------KPVPE----EKVAVPVPVAKKAPPPRAEVSKKTVV------EEKRFVAEEKL 9474

Query: 494  PTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDY 553
                PQ  E  +     E+E   S           E+ +  S   E E          +Y
Sbjct: 9475 SFAVPQRVEVTRHEVSAEEEWSYS---------EEEEGVSISVYREEEREEEEEAEVTEY 9525

Query: 554  IPQDSPTPSVRQ-----IRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDD 608
               + P   V +     I   +EA  +   E++ K     +  KP++             
Sbjct: 9526 EVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEK----KIVLKPKIPA----------- 9570

Query: 609  KLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPP--------KATPEPAIPPK 654
            K+ +P    +P     ++P   +         +PP        K  PE  +PPK
Sbjct: 9571 KIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPK 9624



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 163/802 (20%), Positives = 246/802 (30%), Gaps = 162/802 (20%)

Query: 139   IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAP---------P 189
             + PP P     P + + E     P+P     APP  P + + P P    P         P
Sbjct: 9309  VEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAP 9368

Query: 190   PPPVLEALSPPHTLSSPSIPT-----PPDFIP------------PAPPLAFLAPPPPPVP 232
             P  V E      T    +I T     PP  +P            P P      PPPP VP
Sbjct: 9369  PAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVP 9428

Query: 233   A-PAPPAP----ASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSA 287
             A P  P P    A P  V  +  PP                ++ T     R  AE K   
Sbjct: 9429  ALPKKPVPEEKVAVPVPVAKKAPPP------------RAEVSKKTVVEEKRFVAEEK--- 9473

Query: 288   LGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIR 347
                          SF VP    V    +  +E      +EEG +                
Sbjct: 9474  ------------LSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAE 9521

Query: 348   PASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPL----PPPAPPL 403
                    +   E     +L   +          ++  E+     P  P     PPPA   
Sbjct: 9522  VTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVP 9581

Query: 404   PPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKP-----NPPSPEN------ 452
               P   +P    P P  +K   PP    + PK   P  K  P       P P        
Sbjct: 9582  EAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHM 9641

Query: 453   ------------TASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQS 500
                         T   AP   R P + ++           +  E++ L  +P     P +
Sbjct: 9642  QITQEEKVLVAVTKKEAPPKARVPEEPKR-----------AVPEEKVLKLKPKREEEPPA 9690

Query: 501   KEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSV--------- 551
             K  +   R+ ++E +     K  P  + E ++    + E E A +L   +V         
Sbjct: 9691  KVTEFRKRVVKEEKVSIEAPKREPQPIKEVTI----MEEKERAYTLEEEAVSVQREEEYE 9746

Query: 552   -----DY--IPQDSPTPSVRQIRNELEARLSSAAEKE-----------AKP-SIGSLPPK 592
                  DY    +  PT    Q     E       E E            KP     +P K
Sbjct: 9747  EYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTK 9806

Query: 593   PRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKAT------ 646
             P+    ++ +    ++K+  P+ K L P      P    +PK +    I    T      
Sbjct: 9807  PKAPPAKVLKKAVPEEKVPVPIPKKLKPPP----PKVPEEPKKVFEEKIRISITKREKEQ 9862

Query: 647   -PEPA----IPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTT 701
               EPA    + PK  +     P      A P++    P  P +    P   +    + T 
Sbjct: 9863  VTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRV---PEVPKELE--PEEVAFEEEVVTH 9917

Query: 702   TSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPG 761
               + + E++     + E+  ++E   P          E  R P    +     P K    
Sbjct: 9918  VEEYLVEEEEEYIHEEEEFITEEEVVPVI---PVKVPEVPRKPVPEEKKPVPVPKKKEAP 9974

Query: 762   GGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAG----PGEPV-EVKEPPGLPAKPPAS 816
               +VP + K          +V V++P   +   A     P +PV E K P  +P K  A 
Sbjct: 9975  PAKVPEVPK------KPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAP 10028

Query: 817   AQPTDELLRHPVTGEVVERGSP 838
                  E+ + PV  + V   +P
Sbjct: 10029 PAKVPEVPKKPVPEKKVPVPAP 10050



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 148/714 (20%), Positives = 215/714 (30%), Gaps = 98/714 (13%)

Query: 136  DLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLE 195
            +L  P  P    P P   I   P   P   PP  APP P LL    P P    PPP  +E
Sbjct: 8931 ELKPPDIPDSRVPIPTMPIRAVP---PEEIPPVVAPPIPLLL----PTPEEKKPPPKRIE 8983

Query: 196  ALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPP-VPAPAPPAPASPHTVGTRLFPPGG 254
                     +  +   P  + P   +    PPP   +PA AP                  
Sbjct: 8984 VTKKAVKKDAKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAPEI---------------- 9027

Query: 255  VTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPH---LTFPRSFKVPPPTPVR 311
                  DV+    + +    +  +   + K +        H     F  SF+ P      
Sbjct: 9028 -----IDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYD---E 9079

Query: 312  TSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIR-----PASQVYPDRAPEPDCPGEL 366
                P  E  E P  EE        ++      H          Q Y +R    D   E 
Sbjct: 9080 LEVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEE 9139

Query: 367  KATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHP 426
               A     + Q Q +  E +        +P    P PP     P        +++    
Sbjct: 9140 WEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEE 9199

Query: 427  PAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGS---RR 483
                TK P+ S   +  KP+               R P Q E +  ++ A          
Sbjct: 9200 KVQVTKVPEVSKKIVPQKPS---------------RTPVQEEVIEVKVPAVHTKKMVISE 9244

Query: 484  EDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAA 543
            E  F +      V+    E +K     EK  +      + PP VPE           E A
Sbjct: 9245 EKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELP---EKPAPEEVA 9301

Query: 544  PSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICEN 603
            P      V+      P    + +  E +       E  A P +  +P KP          
Sbjct: 9302 PVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKP---------- 9351

Query: 604  GADDDKLSKPVA--KNLPP-------------QSTTLLPTTSLQPKAMLGPAIPPKATPE 648
               ++K+  PVA  K  PP             +  T++      P   + P IP K  PE
Sbjct: 9352 -VPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAV-PEIPKKKVPE 9409

Query: 649  PAIP-PKATLWPATPPKATLGPATPL--KATSGPTTPLKATSGPAIASTATTLPTTTSQL 705
               P P+       PPK    P  P+  +  + P    K    P    +  T+      +
Sbjct: 9410 ERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFV 9469

Query: 706  MAEKDSGPAGQPEKPASQEVSTPSQ-ARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGE 764
              EK S    Q  +    EVS   + +  E     +  +  +  R        T     E
Sbjct: 9470 AEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVME 9529

Query: 765  VPCLY----KPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPP 814
             P  Y    K H     +  E A V     +     P  P +++EPP  PAK P
Sbjct: 9530 EPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPP--PAKVP 9581



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 107/519 (20%), Positives = 182/519 (35%), Gaps = 138/519 (26%)

Query: 504  KKGPRLPEKETLLSL--PAKDTPPGV-PEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPT 560
            +K  R P +E ++ +  PA  T   V  E+ +  +S TE E   S+T+P V         
Sbjct: 9216 QKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEV--SVTVPEVQ-------- 9265

Query: 561  PSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPP 620
               ++I  E +  ++ +   E  P +  LP KP           A ++    P+ K + P
Sbjct: 9266 ---KEIVTEEKIHVAISKRVEPPPKVPELPEKP-----------APEEVAPVPIPKKVEP 9311

Query: 621  QSTTLLPTTSLQPKAMLGPAIPPKATPEPAIP-PKATLWPATPPKATLGPATPLKATSGP 679
             +          PK    P +P K  PE   P P     PA PPK    P  P+     P
Sbjct: 9312 PA----------PKV---PEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIP 9358

Query: 680  TTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP---ASQEVSTPSQARGEGS 736
                K                       +K++ PA  PE      ++E  T    R E  
Sbjct: 9359 VPVAK-----------------------KKEAPPAKVPEVQKGVVTEEKITIVTQREESP 9395

Query: 737  PSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAG 796
            P     +P +                 +VP   KP                         
Sbjct: 9396 PPAVPEIPKK-----------------KVPEERKPV------------------------ 9414

Query: 797  PGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVG 856
            P +  EV  PP +PA P       +E +  PV   V ++  P    ++ +   ++ R V 
Sbjct: 9415 PRKEEEVPPPPKVPALPKKPVP--EEKVAVPVP--VAKKAPPPRAEVSKKTVVEEKRFVA 9470

Query: 857  AALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTT----EI 912
                  ++P  +    H+  A  +  +  +    S +V  +  +E E+++ +T     E 
Sbjct: 9471 EEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEE 9530

Query: 913  PNKW---------GPRLGRDAEGTELS-RRHNWTKPEPQAPVAWERVAPSNLPQGHPLPK 962
            P ++           R+  +AE  E++ R+      +P+ P   E   P+ +P+      
Sbjct: 9531 PEEYVVEEKLHIISKRV--EAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIV 9588

Query: 963  SFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAP 1001
                 P+P  K+E+           PPP+   +P+ P P
Sbjct: 9589 PEKKVPAPVPKKEKV----------PPPKVPEEPKKPVP 9617



 Score = 34.3 bits (77), Expect = 0.73
 Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 6/119 (5%)

Query: 349 ASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLP--PPAPPLPPP 406
           A Q  P + P P  P + K+ +P  P +      A +++ +P    P P      P P P
Sbjct: 245 AGQQLPHKTP-PRIPPKPKSRSPTPPSIAAKAQLARQQSPSPIRHSPSPVRHVRAPTPSP 303

Query: 407 APPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPEN--TASSAPVDWRD 463
              + PAA       ++   P    KT ++S+ A  P+  PP  +    ASS+  + R+
Sbjct: 304 VRSVSPAARISTSPIRSVRSPLLMRKT-QASTVATGPEVPPPWKQEGYVASSSEAEMRE 361



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 34/120 (28%), Positives = 42/120 (35%), Gaps = 22/120 (18%)

Query: 360  PDCPGELKATAPASPRLGQSQSQADERAGT--------PPPAPPLPPPAPPLP----PPA 407
            PD  G     A   PR G+++S A+    T        PP  P    P P +P    PP 
Sbjct: 8897 PDDEGVYSVIARLEPR-GEARSTAELYLTTKEIKLELKPPDIPDSRVPIPTMPIRAVPPE 8955

Query: 408  PPLPPAAPP----LPCAQKAAHPPAGFTKTPK-----SSSPALKPKPNPPSPENTASSAP 458
               P  APP    LP  ++   PP     T K     +     KPK   P  E      P
Sbjct: 8956 EIPPVVAPPIPLLLPTPEEKKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKPPP 9015



 Score = 31.2 bits (69), Expect = 6.1
 Identities = 21/61 (34%), Positives = 26/61 (42%), Gaps = 4/61 (6%)

Query: 181 PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240
           PP P    P PP + A +      SPS    P    P+P     AP P PV + +P A  
Sbjct: 258 PPKPKSRSPTPPSIAAKAQLARQQSPS----PIRHSPSPVRHVRAPTPSPVRSVSPAARI 313

Query: 241 S 241
           S
Sbjct: 314 S 314



 Score = 31.2 bits (69), Expect = 6.1
 Identities = 38/163 (23%), Positives = 61/163 (37%), Gaps = 34/163 (20%)

Query: 889  PNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPE-PQAPVAWE 947
            P     VP +PK+ E  +P   E+P K  P   +     +         PE P+ PV  E
Sbjct: 9297 PEEVAPVP-IPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEE 9355

Query: 948  RVA----------PSNLPQGHP-----------LPKSFSSPPS----PSNKREEEEEEF- 981
            ++           P+ +P+                +  S PP+    P  K  EE +   
Sbjct: 9356 KIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVP 9415

Query: 982  -NFEVIPPPPEFSNDPEPPAPALQY-----LGRQSSPPRNNYS 1018
               E +PPPP+    P+ P P  +      + +++ PPR   S
Sbjct: 9416 RKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVS 9458



 Score = 30.8 bits (68), Expect = 8.0
 Identities = 24/89 (26%), Positives = 37/89 (41%), Gaps = 11/89 (12%)

Query: 139 IPPPPPGPAPGPPQDISEPP-GGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEAL 197
           IPP P   +P PP   ++        PSP   +P P   +  P P P  +  P   + + 
Sbjct: 257 IPPKPKSRSPTPPSIAAKAQLARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSPAARI-ST 315

Query: 198 SPPHTLSSP---------SIPTPPDFIPP 217
           SP  ++ SP         ++ T P+  PP
Sbjct: 316 SPIRSVRSPLLMRKTQASTVATGPEVPPP 344


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score =  107 bits (267), Expect = 7e-23
 Identities = 215/921 (23%), Positives = 315/921 (34%), Gaps = 131/921 (14%)

Query: 140  PPPPPGPAPGPPQDISEPPGGSPLPS--PPSTAPPP--PPLLLEPPPPPSMAPPPPPVLE 195
            PP  PGPA  PPQ     PG +  PS  P ST PPP  P      P  P    PP     
Sbjct: 480  PPQQPGPAKPPPQQ----PGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPG 535

Query: 196  ALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPA---PPAPASPHTVGTRLFPP 252
            +  P     SP+ P+      P        P  PP  +P+   PP+   P T+     P 
Sbjct: 536  SAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTI----CPL 591

Query: 253  GGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRT 312
               T+    V         T             S  G NP PHLT  + +        R 
Sbjct: 592  CNTTELLLHVPEKANFNTCTECQTTVC------SLCGFNPNPHLTEVKEWLCLNCQMKRA 645

Query: 313  --------SSIPVQEAQEAPRKEEGA-TKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCP 363
                     S P  + + AP     A +K +P      P     P   +   +APEP  P
Sbjct: 646  LGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDL--SKAPEPKKP 703

Query: 364  GELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKA 423
              L       P L  S S    +A  PP A  L  PAPP  P  P     AP      K 
Sbjct: 704  PPLVK----QPTLHGSPSA---KAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQ 756

Query: 424  AHPPAGFTKTPKSSSPALKP-----KPNPPSPENTASSAPVDWRDPSQM-----EKLRNE 473
                   T    SSS   KP     K    + E T      D   PSQ      EK+   
Sbjct: 757  PKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPF 816

Query: 474  LAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLG 533
             +  +     + + +SH PGP+   +SK  K+   + +KE       K +P    +    
Sbjct: 817  DSKAIPRPASDSKIISH-PGPS--SESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPK 873

Query: 534  GSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKP 593
            GS    T   P  T       PQ SP P  +  R  L     + A K       S P  P
Sbjct: 874  GSP---TPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPK-------SQPTTP 923

Query: 594  R-LEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQ-PKAMLGPAIPPKATPEPAI 651
            +    G++   GA           ++  Q++ L+ T     P +  GP  P K  P P+ 
Sbjct: 924  QETVTGKLFGFGA-----------SIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQ 972

Query: 652  PPKATLWPATPPKATLGPATPLKATSGPT-TPLKATSGPAIASTATTLPTTTSQLMAEKD 710
            PP +      PPK+T G A P  A S P     KA +   +   A   P T  +   EK 
Sbjct: 973  PPTS----QGPPKST-GQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP-TVKRTETEKK 1026

Query: 711  SGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP---- 766
              P    +   ++        + E SP   +  P    ++      K  P          
Sbjct: 1027 PPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPL--CKTELNIGSKDPPNFNTCTECKN 1084

Query: 767  -----CLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTD 821
                 C + P  H + +   + +   T      A  G+  ++++ P  P+ P AS  P  
Sbjct: 1085 QVCNLCGFNPTPHLTEIQEWLCLNCQT----QRAISGQLGDIRKMPPAPSGPKASPMPV- 1139

Query: 822  ELLRHPVTGEVVERGSPMALLLAARQRAQKG--------RSVGAALGRSSLPGSLRDHSH 873
                 P      +   P  + L  +Q  +            V   L    +P  +     
Sbjct: 1140 -----PTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQK 1194

Query: 874  QAEA-----SSDSIFHSQGTPNSFTVVPKLPK-EAEKDSPLTTE-IPNKWGPRLGRDAE- 925
            Q E+      + ++   +  P    ++P+  K  +E+  PL  E  P     +L  +A+ 
Sbjct: 1195 QEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKT 1254

Query: 926  GTELSRRHNWTKPEPQAPVAWE----RVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEF 981
                 ++H+  K + Q  +A E    RVAP  + +G          PS + +   +E++ 
Sbjct: 1255 SAPEEQKHDLLKSQVQ--IAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDK 1312

Query: 982  NFEVIPPPPEFSNDPEPPAPA 1002
              + I         P+PP  A
Sbjct: 1313 TTKTI------KEQPQPPCTA 1327



 Score =  106 bits (264), Expect = 2e-22
 Identities = 185/785 (23%), Positives = 263/785 (33%), Gaps = 161/785 (20%)

Query: 140 PPPPPGPAPGPPQ-------------DISEPP--------GGSPLPSPPSTAPPPPPLLL 178
           PP    P  GP Q             D S P         G S  PS PS + PP   + 
Sbjct: 251 PPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPP---IQ 307

Query: 179 EPPP--PPSMAP----PPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVP 232
           +P P  PP+  P      P   +  + P  L+ P    P    PP  P     PP  P+ 
Sbjct: 308 QPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLG 367

Query: 233 APAPPA-------PASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKG 285
              PPA       P+S       L  P GV K             A +  P + P +  G
Sbjct: 368 PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGK-----------TPAQQPGPAKPPTQQVG 416

Query: 286 SALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFH 345
           +      +P L  P     P  TPV+        AQ+A   +  A +  P+         
Sbjct: 417 TPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPT--------- 467

Query: 346 IRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLP- 404
            +P SQ+     P P  PG  K   P   + G ++  + +   T PP P  P PA P P 
Sbjct: 468 -KPPSQLPGPAKPPPQQPGPAK---PPPQQPGSAKPPSQQPGSTKPP-PQQPGPAKPSPQ 522

Query: 405 PPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDP 464
            P    PP+  P      A  P        +S+ P  +     P    T S        P
Sbjct: 523 QPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVS--------P 574

Query: 465 SQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGK----------KGPRLPEKET 514
           S  +     L   +C        L H P         E +            P L E + 
Sbjct: 575 SAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKE 634

Query: 515 LLSLPAK---------DTPPGVPEKSLGGSSLTETEAA------PSLTLPSVDYIPQD-- 557
            L L  +            P  P+  L  + +T T A       P  T P  D  P+   
Sbjct: 635 WLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDL 694

Query: 558 -------SPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKL 610
                   P P V+Q    L    S+ A++  +    S P  P+       E     ++ 
Sbjct: 695 SKAPEPKKPPPLVKQ--PTLHGSPSAKAKQPPEADSLSKPAPPK-------EPSVPSEQD 745

Query: 611 SKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA----TPPKAT 666
             PVA + P Q   + PTT L   +         AT +P IP       A    TPP  T
Sbjct: 746 KAPVADDKPKQPKMVKPTTDLVSSS--------SATTKPDIPSSKVQSQAEEKTTPPLKT 797

Query: 667 --LGPATPLKATSGPTTPL--KATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP-- 720
               P+     T    +P   KA   PA  S   + P  +S+   +K   P  + E+P  
Sbjct: 798 DSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKK 857

Query: 721 ASQEVSTPSQAR--GEGSPSEATRLPTQGAR---------------------SSAAFPPK 757
           A  ++S    A+   +GSP+     PT G                        S    PK
Sbjct: 858 AQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPK 917

Query: 758 TSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGG---AAGPGEPVEVKEPPGLPAKPP 814
           + P   +     K     +S+  + + ++ T  + G    +GPG P  +K+ P  P++PP
Sbjct: 918 SQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAP--MKQAPA-PSQPP 974

Query: 815 ASAQP 819
            S  P
Sbjct: 975 TSQGP 979



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 211/1009 (20%), Positives = 319/1009 (31%), Gaps = 139/1009 (13%)

Query: 199  PPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKW 258
            PP    SPS+    +     PP     PP P    PA P  +   T  T          +
Sbjct: 72   PPAAAESPSMHRKQELDSSHPPKQSGRPPDPG--RPAQPGLSKSRTTDT----------F 119

Query: 259  KSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQ 318
            +S+  L GR          +S  + K           L+   +         + +   + 
Sbjct: 120  RSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLI 179

Query: 319  EAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRA-PEPDCPGELKATAPASPRLG 377
               EA ++E    +K   +    P   I+P  Q  P +  P+   PG        +P+  
Sbjct: 180  SDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPK-- 237

Query: 378  QSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSS 437
               SQ  E+  + PP    P   P   P           LP  + A+ P        +  
Sbjct: 238  SISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAK-----LPLQRDASRPQTKQADIVRGE 292

Query: 438  SPALKPKPNPPSPENTASSAPVDWRDPSQM---EKLRNELAAYLCGSRREDRFLSHRPGP 494
            S     KP+ PSP       P   + P+Q    EK +   A          + L+ +PG 
Sbjct: 293  SV----KPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGT 348

Query: 495  TVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTL---PSV 551
               P    G   P           PA+   P  P     GS    +E      L   P V
Sbjct: 349  VKPPVQPPGTTKP-----------PAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGV 397

Query: 552  DYIPQDSPTPS---VRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDD 608
               P   P P+    +Q+            +  AK    +  P  +   G+I    A   
Sbjct: 398  GKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPG 457

Query: 609  KLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLG 668
            K S    +  P +  + LP  +  P    GPA PP   P  A PP        PP    G
Sbjct: 458  KTS--AQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPG 515

Query: 669  PATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTP 728
            PA P     G T P     G A                  K S     P KP++Q+ + P
Sbjct: 516  PAKPSPQQPGSTKPPSQQPGSA------------------KPSAQQPSPAKPSAQQSTKP 557

Query: 729  SQARGEGSPSE-------ATRLPTQGARSSAAFPPKTSPGGGEVP--------------- 766
                G G P +       A + P+QG   +      T+     VP               
Sbjct: 558  VSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTV 617

Query: 767  ---CLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDEL 823
               C + P+ H + +   +   +    +    G   PV     P L   P  +     + 
Sbjct: 618  CSLCGFNPNPHLTEVKEWLC--LNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKS 675

Query: 824  LRHPVTGEVVERGSPMALLLAARQRAQKGRSV------GAALGRSSLPGSLRDHSHQAEA 877
               P      +  +P   L  A +  +    V      G+   ++  P      S  A  
Sbjct: 676  SPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPP 735

Query: 878  SSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRL------GRDAEGTELSR 931
               S+   Q         PK PK  +  + L +       P +       +  E T    
Sbjct: 736  KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPL 795

Query: 932  RHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFS---SPPSPSN-----------KREEE 977
            + +  KP    P   E+V+P +  +  P P S S   S P PS+           +++EE
Sbjct: 796  KTDSAKPSQSFPPTGEKVSPFD-SKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEE 854

Query: 978  EEEFNFEVIPPP---PEFSNDPEPPAP---ALQYLGRQSSPPRNNYSDLRQLPNAG--PG 1029
             ++   ++ P P   P     P PP P   A Q +      P+      R   N G    
Sbjct: 855  PKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITD 914

Query: 1030 APPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSP 1089
            AP +      P   +    G   +  G G S+  +   +      PG PH  +G    +P
Sbjct: 915  APKSQ-----PTTPQETVTG---KLFGFGASIFSQASNLISTAGQPG-PHSQSGP--GAP 963

Query: 1090 NCFGPQPGGPEMRR--VNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKA 1136
                P P  P   +    S G+APP    +  +  E  A  A + + KA
Sbjct: 964  MKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKA 1012



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 79/278 (28%), Positives = 102/278 (36%), Gaps = 77/278 (27%)

Query: 347  RPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP 406
            +PASQ+ P  +P         ++ PA PR     S  D  A  PPP PP PPP PP PPP
Sbjct: 2371 KPASQL-PSGSPSV-------SSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPP 2422

Query: 407  -APPLPP----------------AAP---------------------------------- 415
              PPLPP                A+P                                  
Sbjct: 2423 PPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTA 2482

Query: 416  PLPCAQKAAHPPAG--FTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNE 473
            P P   K +  P+G  FT  P+ S P + PKP  P    T +  P D         L + 
Sbjct: 2483 PPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLP-TTTQKPTDIHPKPTGLSLTSS 2541

Query: 474  LAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPR----LPEKETLLSLPAKDTPPGVPE 529
            +   L  S   D  L   P PT        K  PR    L E   +++LP++   PG P 
Sbjct: 2542 MTLNLVTS--ADYKL---PSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSE---PGTPT 2593

Query: 530  KSLGGSSLTETE-AAPSLTLPSVDYIPQDSPTPSVRQI 566
             S    ++T     +PS  L SV+  P  S  P V  +
Sbjct: 2594 DSSASQAITSWPLGSPSKDLVSVE--PVFSVVPPVTAV 2629



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 55/176 (31%), Positives = 65/176 (36%), Gaps = 23/176 (13%)

Query: 140  PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPP---PPLLLEPPPPPSMAPPPPPVLEA 196
            PPPPP P P PP     PP   P P PP T+P P   P   L    P + A P    +  
Sbjct: 2407 PPPPPPPPPPPP-----PPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTT 2461

Query: 197  LSPPHTLSSPSIP------TPPDFIPPAPP-----LAFLAPPPPPVP--APAPPAPASPH 243
            L     L S  +P      T P  +PP P      L F   P P  P  AP P  P  P 
Sbjct: 2462 LETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPT 2521

Query: 244  TV--GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLT 297
            T    T + P        S + LN   +   +   P SP  P  +   P     LT
Sbjct: 2522 TTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLT 2577



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 68/269 (25%), Positives = 91/269 (33%), Gaps = 72/269 (26%)

Query: 145  GPAPGPPQDISEPPGGSP----LPSPP-----------STAPPPPPLLLEPPPPPSMAPP 189
            G   G  +  S+ P GSP    LP+ P           S  PPPPP    PPPPP   PP
Sbjct: 2364 GETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPP 2423

Query: 190  PPPVLEALSPPHTL--------SSPSIPTPPDFIP---------------PAPPLAFLAP 226
            PPP+    SP  T+        +SP     P F                 P   +   AP
Sbjct: 2424 PPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAP 2483

Query: 227  PP-PPVPAPAP--------PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPP 277
            PP PP P+  P        P P+ P      + P                Q   T   P 
Sbjct: 2484 PPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIP----------------QLPTTTQKPT 2527

Query: 278  RSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATK----- 332
                +P G +L  +   +L     +K+P P    TS +     + +PR  +  T+     
Sbjct: 2528 DIHPKPTGLSLTSSMTLNLVTSADYKLPSP----TSPLSPHSNKSSPRFSKSLTETYVVI 2583

Query: 333  KAPSRLPLPPSFHIRPASQVYPDRAPEPD 361
              PS    P       A   +P  +P  D
Sbjct: 2584 TLPSEPGTPTDSSASQAITSWPLGSPSKD 2612



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 81/353 (22%), Positives = 123/353 (34%), Gaps = 60/353 (16%)

Query: 567  RNELEARLSSAAEKEA-----KPSIGSLPPKPRLEGGRIC-------ENGADDDKLSKPV 614
            + ELEA  + ++  E        S+ +LP K +L             E  A       P 
Sbjct: 2323 KKELEAERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPS 2382

Query: 615  AKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKAT--LWPATPPKATLGP--- 669
              +LP +      ++SL   A   P  PP   P P  PP     L P T PK T+ P   
Sbjct: 2383 VSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKK 2442

Query: 670  ---------ATPL--KATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSG------ 712
                     ATPL    T+  TT +  ++G  +    TT P       +   SG      
Sbjct: 2443 LTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHR 2502

Query: 713  --PAGQP--EKPASQEVSTPSQARGEGSPS----EATRLPTQGARSSAAF--PPKTSPGG 762
              P+  P   KP   ++ T +Q   +  P       T   T    +SA +  P  TSP  
Sbjct: 2503 PEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSP-- 2560

Query: 763  GEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVE-------VKEPPGLPAKPPA 815
                    PH ++SS     ++    +     + PG P +          P G P+K   
Sbjct: 2561 ------LSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAITSWPLGSPSKDLV 2614

Query: 816  SAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSL 868
            S +P   ++  PVT   +   S     ++   +      V A     + P S+
Sbjct: 2615 SVEPVFSVV-PPVTAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAAPTSV 2666



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 18/62 (29%), Positives = 26/62 (41%)

Query: 121  LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180
            LYS +  L PG+  +   +P   P P    PQ +  P      P+ P TA      + +P
Sbjct: 3623 LYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDP 3682

Query: 181  PP 182
             P
Sbjct: 3683 KP 3684



 Score = 32.0 bits (71), Expect = 3.6
 Identities = 39/147 (26%), Positives = 48/147 (32%), Gaps = 29/147 (19%)

Query: 165  SPPSTAPPPPPLL------LEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIP-- 216
            SPP     P PL       L       +AP PP   + L  P +  SP       F+P  
Sbjct: 3585 SPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYE 3644

Query: 217  -PAP----PLAFLAPPPPPVPAPAP------------PAPASPHTVGTRLFP----PGGV 255
             P P    P   L P    VP  +P            P P SP    +   P     G  
Sbjct: 3645 KPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYTEGYT 3704

Query: 256  TKWKSDVALNGRQAEATRASPPRSPAE 282
            TK    +  +G Q +  R  P   P E
Sbjct: 3705 TKGSQTMTSSGAQKKVKRTLPNPPPEE 3731


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score =  107 bits (267), Expect = 7e-23
 Identities = 215/921 (23%), Positives = 315/921 (34%), Gaps = 131/921 (14%)

Query: 140  PPPPPGPAPGPPQDISEPPGGSPLPS--PPSTAPPP--PPLLLEPPPPPSMAPPPPPVLE 195
            PP  PGPA  PPQ     PG +  PS  P ST PPP  P      P  P    PP     
Sbjct: 480  PPQQPGPAKPPPQQ----PGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPG 535

Query: 196  ALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPA---PPAPASPHTVGTRLFPP 252
            +  P     SP+ P+      P        P  PP  +P+   PP+   P T+     P 
Sbjct: 536  SAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTI----CPL 591

Query: 253  GGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRT 312
               T+    V         T             S  G NP PHLT  + +        R 
Sbjct: 592  CNTTELLLHVPEKANFNTCTECQTTVC------SLCGFNPNPHLTEVKEWLCLNCQMKRA 645

Query: 313  --------SSIPVQEAQEAPRKEEGA-TKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCP 363
                     S P  + + AP     A +K +P      P     P   +   +APEP  P
Sbjct: 646  LGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDL--SKAPEPKKP 703

Query: 364  GELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKA 423
              L       P L  S S    +A  PP A  L  PAPP  P  P     AP      K 
Sbjct: 704  PPLVK----QPTLHGSPSA---KAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQ 756

Query: 424  AHPPAGFTKTPKSSSPALKP-----KPNPPSPENTASSAPVDWRDPSQM-----EKLRNE 473
                   T    SSS   KP     K    + E T      D   PSQ      EK+   
Sbjct: 757  PKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPF 816

Query: 474  LAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLG 533
             +  +     + + +SH PGP+   +SK  K+   + +KE       K +P    +    
Sbjct: 817  DSKAIPRPASDSKIISH-PGPS--SESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPK 873

Query: 534  GSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKP 593
            GS    T   P  T       PQ SP P  +  R  L     + A K       S P  P
Sbjct: 874  GSP---TPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPK-------SQPTTP 923

Query: 594  R-LEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQ-PKAMLGPAIPPKATPEPAI 651
            +    G++   GA           ++  Q++ L+ T     P +  GP  P K  P P+ 
Sbjct: 924  QETVTGKLFGFGA-----------SIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQ 972

Query: 652  PPKATLWPATPPKATLGPATPLKATSGPT-TPLKATSGPAIASTATTLPTTTSQLMAEKD 710
            PP +      PPK+T G A P  A S P     KA +   +   A   P T  +   EK 
Sbjct: 973  PPTS----QGPPKST-GQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP-TVKRTETEKK 1026

Query: 711  SGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP---- 766
              P    +   ++        + E SP   +  P    ++      K  P          
Sbjct: 1027 PPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPL--CKTELNIGSKDPPNFNTCTECKN 1084

Query: 767  -----CLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTD 821
                 C + P  H + +   + +   T      A  G+  ++++ P  P+ P AS  P  
Sbjct: 1085 QVCNLCGFNPTPHLTEIQEWLCLNCQT----QRAISGQLGDIRKMPPAPSGPKASPMPV- 1139

Query: 822  ELLRHPVTGEVVERGSPMALLLAARQRAQKG--------RSVGAALGRSSLPGSLRDHSH 873
                 P      +   P  + L  +Q  +            V   L    +P  +     
Sbjct: 1140 -----PTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQK 1194

Query: 874  QAEA-----SSDSIFHSQGTPNSFTVVPKLPK-EAEKDSPLTTE-IPNKWGPRLGRDAE- 925
            Q E+      + ++   +  P    ++P+  K  +E+  PL  E  P     +L  +A+ 
Sbjct: 1195 QEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKT 1254

Query: 926  GTELSRRHNWTKPEPQAPVAWE----RVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEF 981
                 ++H+  K + Q  +A E    RVAP  + +G          PS + +   +E++ 
Sbjct: 1255 SAPEEQKHDLLKSQVQ--IAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDK 1312

Query: 982  NFEVIPPPPEFSNDPEPPAPA 1002
              + I         P+PP  A
Sbjct: 1313 TTKTI------KEQPQPPCTA 1327



 Score =  106 bits (264), Expect = 2e-22
 Identities = 185/785 (23%), Positives = 263/785 (33%), Gaps = 161/785 (20%)

Query: 140 PPPPPGPAPGPPQ-------------DISEPP--------GGSPLPSPPSTAPPPPPLLL 178
           PP    P  GP Q             D S P         G S  PS PS + PP   + 
Sbjct: 251 PPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPP---IQ 307

Query: 179 EPPP--PPSMAP----PPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVP 232
           +P P  PP+  P      P   +  + P  L+ P    P    PP  P     PP  P+ 
Sbjct: 308 QPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLG 367

Query: 233 APAPPA-------PASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKG 285
              PPA       P+S       L  P GV K             A +  P + P +  G
Sbjct: 368 PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGK-----------TPAQQPGPAKPPTQQVG 416

Query: 286 SALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFH 345
           +      +P L  P     P  TPV+        AQ+A   +  A +  P+         
Sbjct: 417 TPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPT--------- 467

Query: 346 IRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLP- 404
            +P SQ+     P P  PG  K   P   + G ++  + +   T PP P  P PA P P 
Sbjct: 468 -KPPSQLPGPAKPPPQQPGPAK---PPPQQPGSAKPPSQQPGSTKPP-PQQPGPAKPSPQ 522

Query: 405 PPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDP 464
            P    PP+  P      A  P        +S+ P  +     P    T S        P
Sbjct: 523 QPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVS--------P 574

Query: 465 SQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGK----------KGPRLPEKET 514
           S  +     L   +C        L H P         E +            P L E + 
Sbjct: 575 SAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKE 634

Query: 515 LLSLPAK---------DTPPGVPEKSLGGSSLTETEAA------PSLTLPSVDYIPQD-- 557
            L L  +            P  P+  L  + +T T A       P  T P  D  P+   
Sbjct: 635 WLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDL 694

Query: 558 -------SPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKL 610
                   P P V+Q    L    S+ A++  +    S P  P+       E     ++ 
Sbjct: 695 SKAPEPKKPPPLVKQ--PTLHGSPSAKAKQPPEADSLSKPAPPK-------EPSVPSEQD 745

Query: 611 SKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA----TPPKAT 666
             PVA + P Q   + PTT L   +         AT +P IP       A    TPP  T
Sbjct: 746 KAPVADDKPKQPKMVKPTTDLVSSS--------SATTKPDIPSSKVQSQAEEKTTPPLKT 797

Query: 667 --LGPATPLKATSGPTTPL--KATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP-- 720
               P+     T    +P   KA   PA  S   + P  +S+   +K   P  + E+P  
Sbjct: 798 DSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKK 857

Query: 721 ASQEVSTPSQAR--GEGSPSEATRLPTQGAR---------------------SSAAFPPK 757
           A  ++S    A+   +GSP+     PT G                        S    PK
Sbjct: 858 AQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPK 917

Query: 758 TSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGG---AAGPGEPVEVKEPPGLPAKPP 814
           + P   +     K     +S+  + + ++ T  + G    +GPG P  +K+ P  P++PP
Sbjct: 918 SQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAP--MKQAPA-PSQPP 974

Query: 815 ASAQP 819
            S  P
Sbjct: 975 TSQGP 979



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 211/1009 (20%), Positives = 319/1009 (31%), Gaps = 139/1009 (13%)

Query: 199  PPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKW 258
            PP    SPS+    +     PP     PP P    PA P  +   T  T          +
Sbjct: 72   PPAAAESPSMHRKQELDSSHPPKQSGRPPDPG--RPAQPGLSKSRTTDT----------F 119

Query: 259  KSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQ 318
            +S+  L GR          +S  + K           L+   +         + +   + 
Sbjct: 120  RSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLI 179

Query: 319  EAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRA-PEPDCPGELKATAPASPRLG 377
               EA ++E    +K   +    P   I+P  Q  P +  P+   PG        +P+  
Sbjct: 180  SDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPK-- 237

Query: 378  QSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSS 437
               SQ  E+  + PP    P   P   P           LP  + A+ P        +  
Sbjct: 238  SISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAK-----LPLQRDASRPQTKQADIVRGE 292

Query: 438  SPALKPKPNPPSPENTASSAPVDWRDPSQM---EKLRNELAAYLCGSRREDRFLSHRPGP 494
            S     KP+ PSP       P   + P+Q    EK +   A          + L+ +PG 
Sbjct: 293  SV----KPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGT 348

Query: 495  TVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTL---PSV 551
               P    G   P           PA+   P  P     GS    +E      L   P V
Sbjct: 349  VKPPVQPPGTTKP-----------PAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGV 397

Query: 552  DYIPQDSPTPS---VRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDD 608
               P   P P+    +Q+            +  AK    +  P  +   G+I    A   
Sbjct: 398  GKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPG 457

Query: 609  KLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLG 668
            K S    +  P +  + LP  +  P    GPA PP   P  A PP        PP    G
Sbjct: 458  KTS--AQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPG 515

Query: 669  PATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTP 728
            PA P     G T P     G A                  K S     P KP++Q+ + P
Sbjct: 516  PAKPSPQQPGSTKPPSQQPGSA------------------KPSAQQPSPAKPSAQQSTKP 557

Query: 729  SQARGEGSPSE-------ATRLPTQGARSSAAFPPKTSPGGGEVP--------------- 766
                G G P +       A + P+QG   +      T+     VP               
Sbjct: 558  VSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTV 617

Query: 767  ---CLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDEL 823
               C + P+ H + +   +   +    +    G   PV     P L   P  +     + 
Sbjct: 618  CSLCGFNPNPHLTEVKEWLC--LNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKS 675

Query: 824  LRHPVTGEVVERGSPMALLLAARQRAQKGRSV------GAALGRSSLPGSLRDHSHQAEA 877
               P      +  +P   L  A +  +    V      G+   ++  P      S  A  
Sbjct: 676  SPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPP 735

Query: 878  SSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRL------GRDAEGTELSR 931
               S+   Q         PK PK  +  + L +       P +       +  E T    
Sbjct: 736  KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPL 795

Query: 932  RHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFS---SPPSPSN-----------KREEE 977
            + +  KP    P   E+V+P +  +  P P S S   S P PS+           +++EE
Sbjct: 796  KTDSAKPSQSFPPTGEKVSPFD-SKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEE 854

Query: 978  EEEFNFEVIPPP---PEFSNDPEPPAP---ALQYLGRQSSPPRNNYSDLRQLPNAG--PG 1029
             ++   ++ P P   P     P PP P   A Q +      P+      R   N G    
Sbjct: 855  PKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITD 914

Query: 1030 APPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSP 1089
            AP +      P   +    G   +  G G S+  +   +      PG PH  +G    +P
Sbjct: 915  APKSQ-----PTTPQETVTG---KLFGFGASIFSQASNLISTAGQPG-PHSQSGP--GAP 963

Query: 1090 NCFGPQPGGPEMRR--VNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKA 1136
                P P  P   +    S G+APP    +  +  E  A  A + + KA
Sbjct: 964  MKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKA 1012



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 79/278 (28%), Positives = 102/278 (36%), Gaps = 77/278 (27%)

Query: 347  RPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP 406
            +PASQ+ P  +P         ++ PA PR     S  D  A  PPP PP PPP PP PPP
Sbjct: 2371 KPASQL-PSGSPSV-------SSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPP 2422

Query: 407  -APPLPP----------------AAP---------------------------------- 415
              PPLPP                A+P                                  
Sbjct: 2423 PPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTA 2482

Query: 416  PLPCAQKAAHPPAG--FTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNE 473
            P P   K +  P+G  FT  P+ S P + PKP  P    T +  P D         L + 
Sbjct: 2483 PPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLP-TTTQKPTDIHPKPTGLSLTSS 2541

Query: 474  LAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPR----LPEKETLLSLPAKDTPPGVPE 529
            +   L  S   D  L   P PT        K  PR    L E   +++LP++   PG P 
Sbjct: 2542 MTLNLVTS--ADYKL---PSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSE---PGTPT 2593

Query: 530  KSLGGSSLTETE-AAPSLTLPSVDYIPQDSPTPSVRQI 566
             S    ++T     +PS  L SV+  P  S  P V  +
Sbjct: 2594 DSSASQAITSWPLGSPSKDLVSVE--PVFSVVPPVTAV 2629



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 55/176 (31%), Positives = 65/176 (36%), Gaps = 23/176 (13%)

Query: 140  PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPP---PPLLLEPPPPPSMAPPPPPVLEA 196
            PPPPP P P PP     PP   P P PP T+P P   P   L    P + A P    +  
Sbjct: 2407 PPPPPPPPPPPP-----PPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTT 2461

Query: 197  LSPPHTLSSPSIP------TPPDFIPPAPP-----LAFLAPPPPPVP--APAPPAPASPH 243
            L     L S  +P      T P  +PP P      L F   P P  P  AP P  P  P 
Sbjct: 2462 LETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPT 2521

Query: 244  TV--GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLT 297
            T    T + P        S + LN   +   +   P SP  P  +   P     LT
Sbjct: 2522 TTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLT 2577



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 68/269 (25%), Positives = 91/269 (33%), Gaps = 72/269 (26%)

Query: 145  GPAPGPPQDISEPPGGSP----LPSPP-----------STAPPPPPLLLEPPPPPSMAPP 189
            G   G  +  S+ P GSP    LP+ P           S  PPPPP    PPPPP   PP
Sbjct: 2364 GETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPP 2423

Query: 190  PPPVLEALSPPHTL--------SSPSIPTPPDFIP---------------PAPPLAFLAP 226
            PPP+    SP  T+        +SP     P F                 P   +   AP
Sbjct: 2424 PPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAP 2483

Query: 227  PP-PPVPAPAP--------PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPP 277
            PP PP P+  P        P P+ P      + P                Q   T   P 
Sbjct: 2484 PPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIP----------------QLPTTTQKPT 2527

Query: 278  RSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATK----- 332
                +P G +L  +   +L     +K+P P    TS +     + +PR  +  T+     
Sbjct: 2528 DIHPKPTGLSLTSSMTLNLVTSADYKLPSP----TSPLSPHSNKSSPRFSKSLTETYVVI 2583

Query: 333  KAPSRLPLPPSFHIRPASQVYPDRAPEPD 361
              PS    P       A   +P  +P  D
Sbjct: 2584 TLPSEPGTPTDSSASQAITSWPLGSPSKD 2612



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 81/353 (22%), Positives = 123/353 (34%), Gaps = 60/353 (16%)

Query: 567  RNELEARLSSAAEKEA-----KPSIGSLPPKPRLEGGRIC-------ENGADDDKLSKPV 614
            + ELEA  + ++  E        S+ +LP K +L             E  A       P 
Sbjct: 2323 KKELEAERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPS 2382

Query: 615  AKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKAT--LWPATPPKATLGP--- 669
              +LP +      ++SL   A   P  PP   P P  PP     L P T PK T+ P   
Sbjct: 2383 VSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKK 2442

Query: 670  ---------ATPL--KATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSG------ 712
                     ATPL    T+  TT +  ++G  +    TT P       +   SG      
Sbjct: 2443 LTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHR 2502

Query: 713  --PAGQP--EKPASQEVSTPSQARGEGSPS----EATRLPTQGARSSAAF--PPKTSPGG 762
              P+  P   KP   ++ T +Q   +  P       T   T    +SA +  P  TSP  
Sbjct: 2503 PEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSP-- 2560

Query: 763  GEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVE-------VKEPPGLPAKPPA 815
                    PH ++SS     ++    +     + PG P +          P G P+K   
Sbjct: 2561 ------LSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAITSWPLGSPSKDLV 2614

Query: 816  SAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSL 868
            S +P   ++  PVT   +   S     ++   +      V A     + P S+
Sbjct: 2615 SVEPVFSVV-PPVTAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAAPTSV 2666



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 18/62 (29%), Positives = 26/62 (41%)

Query: 121  LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180
            LYS +  L PG+  +   +P   P P    PQ +  P      P+ P TA      + +P
Sbjct: 3623 LYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDP 3682

Query: 181  PP 182
             P
Sbjct: 3683 KP 3684



 Score = 32.0 bits (71), Expect = 3.6
 Identities = 39/147 (26%), Positives = 48/147 (32%), Gaps = 29/147 (19%)

Query: 165  SPPSTAPPPPPLL------LEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIP-- 216
            SPP     P PL       L       +AP PP   + L  P +  SP       F+P  
Sbjct: 3585 SPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYE 3644

Query: 217  -PAP----PLAFLAPPPPPVPAPAP------------PAPASPHTVGTRLFP----PGGV 255
             P P    P   L P    VP  +P            P P SP    +   P     G  
Sbjct: 3645 KPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYTEGYT 3704

Query: 256  TKWKSDVALNGRQAEATRASPPRSPAE 282
            TK    +  +G Q +  R  P   P E
Sbjct: 3705 TKGSQTMTSSGAQKKVKRTLPNPPPEE 3731


>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
            sapiens]
          Length = 1636

 Score =  107 bits (266), Expect = 9e-23
 Identities = 111/396 (28%), Positives = 144/396 (36%), Gaps = 47/396 (11%)

Query: 126  GDLRPGQY-GQDLLIPPPPPGP-----APGPP--------QDISEPPGGSP----LPSPP 167
            G L PG Y G   LI P  PGP     APGP          ++   P  SP    + SP 
Sbjct: 789  GPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPY 848

Query: 168  STAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPP 227
                P PP+   P  PP     P   +       T+ S   P P    P   P    APP
Sbjct: 849  VGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPNPTP--APP 906

Query: 228  PPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSA 287
            PP  P P P    +P+T       P       S     G  A      P   P      A
Sbjct: 907  PPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQA 966

Query: 288  LGPNP--------EPHLTFPRS-FKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRL 338
             GP P         PHL  P++   +PP +P   +  P    Q  P          P++ 
Sbjct: 967  FGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHT-QLYPGPAQD 1025

Query: 339  PLPPSFHIRPASQVYPDRAPEPDCP-GELKATAPASPRLGQSQSQADERAGTPPPAPPL- 396
            PLP      P     P + P P    G   +T P  P+      +    AG   P+P L 
Sbjct: 1026 PLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLV 1085

Query: 397  PPPAP-PLPPPAPPLPPAAPPLPCAQKAA----------HPPAGFTKTPKSSSPALKPKP 445
            P PAP P P P PP PPAA P PC ++ A              G T++P    P L+P  
Sbjct: 1086 PSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPLLQPTK 1145

Query: 446  NPPSPENTASSAPVDWRD----PSQMEKLRNELAAY 477
               +      +  +  RD    P ++ +L+ EL A+
Sbjct: 1146 VDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAF 1181



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 129/560 (23%), Positives = 166/560 (29%), Gaps = 162/560 (28%)

Query: 230  PVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPK--GSA 287
            P P P  P P  P              + +S+    G   E  R+ PP   A P+   + 
Sbjct: 716  PPPRPTAPKPLLPR-------------REESEAVEAGDPPEELRSLPPDMVAGPRLPDTF 762

Query: 288  LGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIR 347
            LG     H          PP+P  +S+ P       P    G         PLPP  +  
Sbjct: 763  LGSATPLHF---------PPSPFPSSTGP------GPHYLSG---------PLPPGTYSG 798

Query: 348  PASQVYPDRAPEPDC----PGELKATAPA-SPRLGQSQSQADERAGTPPPAPPLPPPAPP 402
            P   + P RAP P      PG     APA +P LG     + +      P   + P    
Sbjct: 799  PTQLIQP-RAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPA--- 854

Query: 403  LPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWR 462
              PP   LP A PP                  + S P L     P +    +  AP+   
Sbjct: 855  --PPVAGLPSAPPP------------------QFSGPELAMAVRPATTTVDSIQAPI--- 891

Query: 463  DPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKD 522
             PS                       + RP PT AP        P  P       LP   
Sbjct: 892  -PSHT---------------------APRPNPTPAPPPPCFPVPPPQP-------LPTPY 922

Query: 523  TPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEA 582
            T P   ++ +       +        P +   PQ  P P   Q                 
Sbjct: 923  TYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQ----------------- 965

Query: 583  KPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKA----MLG 638
              + G  PP+  L              L  P     PPQ+  LLP  S  P A    +LG
Sbjct: 966  --AFGPQPPQQPLP-------------LQHPHL--FPPQAPGLLPPQSPYPYAPQPGVLG 1008

Query: 639  PAIPPKAT---PEPAIPPKATLWPATP-----------PKATLGPATPLKATSGPTTPLK 684
               PP  T   P PA  P      A P           P    GPA P     GP     
Sbjct: 1009 QPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPA-PSTRPMGPQAAPL 1067

Query: 685  ATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLP 744
               GP+ A  +T  P            GP   P  PA++    P   RG  +    +  P
Sbjct: 1068 TIRGPSSAGQSTPSPHLVPSPAPSPGPGPV-PPRPPAAE--PPPCLRRGAAAADLLSSSP 1124

Query: 745  TQGARSSAAFPPKTSPGGGE 764
                   +      SPGGG+
Sbjct: 1125 ------ESQHGGTQSPGGGQ 1138



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 33/80 (41%), Positives = 38/80 (47%), Gaps = 10/80 (12%)

Query: 157  PPGG--SPLPSPPSTAPPP---PPLLLEPPPPPSMAPPP--PPVLEALSPPHTLSSPSIP 209
            PPGG  SP+ S P  A PP   P  L E  P PS +PPP   P+ EA   P     P +P
Sbjct: 1509 PPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEA---PQPKEEPPVP 1565

Query: 210  TPPDFIPPAPPLAFLAPPPP 229
              P   PP+  L  LA   P
Sbjct: 1566 EAPSSGPPSSSLELLASLTP 1585



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 107/459 (23%), Positives = 143/459 (31%), Gaps = 92/459 (20%)

Query: 442  KPKPNPPSPE----NTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLS-----HRP 492
            KP P P +P+        S  V+  DP   E+LR+     + G R  D FL      H P
Sbjct: 715  KPPPRPTAPKPLLPRREESEAVEAGDPP--EELRSLPPDMVAGPRLPDTFLGSATPLHFP 772

Query: 493  GPTVAPQSK-------EGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPS 545
             P+  P S         G   P      T L  P    P  +P     G +L     AP+
Sbjct: 773  -PSPFPSSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAP--GPALYP---APA 826

Query: 546  LTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLP--PKPRLEGGRIC-- 601
             T P +  +P+ SP   V           S        P +  LP  P P+  G  +   
Sbjct: 827  YT-PELGLVPRSSPQHGVVS---------SPYVGVGPAPPVAGLPSAPPPQFSGPELAMA 876

Query: 602  --ENGADDDKLSKPVAKNLPPQSTTL---------------LPTTSLQPKAMLGPAIP-- 642
                    D +  P+  +  P+                   LPT    P     P IP  
Sbjct: 877  VRPATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQP-IPAQ 935

Query: 643  -------PKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTA 695
                   P   P P I P+    P   P    GP  P +       PL           A
Sbjct: 936  HHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQ-------PLPLQHPHLFPPQA 988

Query: 696  TTLPTTTSQLMAEKDSGPAGQPEKPA-SQEVSTPSQARGEGSPSEATRLPTQGARSSAAF 754
              L    S        G  GQP  P  +Q    P+Q   +  P+ +  LP         F
Sbjct: 989  PGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQ---DPLPAHSGALP---------F 1036

Query: 755  PPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARG-GAAGPGEPVEVKEPPGLPAKP 813
            P    P     P  Y P      +  + A   P   RG  +AG   P     P   P+  
Sbjct: 1037 PSPGPPQPPHPPLAYGPAPSTRPMGPQAA---PLTIRGPSSAGQSTPSPHLVPSPAPSPG 1093

Query: 814  PASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKG 852
            P    P       P     + RG+  A LL++   +Q G
Sbjct: 1094 PGPVPPRPPAAEPP---PCLRRGAAAADLLSSSPESQHG 1129



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 28/84 (33%), Positives = 35/84 (41%), Gaps = 6/84 (7%)

Query: 137  LLIPPP-----PPGPAPGPPQDISEPPGGSPLPSP-PSTAPPPPPLLLEPPPPPSMAPPP 190
            L I PP     P    PGP +    PP   P  +P PS++PPP    L   P P   PP 
Sbjct: 1505 LSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPV 1564

Query: 191  PPVLEALSPPHTLSSPSIPTPPDF 214
            P    +  P  +L   +  TP  F
Sbjct: 1565 PEAPSSGPPSSSLELLASLTPEAF 1588



 Score = 37.4 bits (85), Expect = 0.086
 Identities = 25/71 (35%), Positives = 32/71 (45%), Gaps = 9/71 (12%)

Query: 388  GTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNP 447
            G   P   LP PA P     P LPPA+ P      ++ PP   +  P+    A +PK  P
Sbjct: 1512 GLESPVASLPGPAEP-----PGLPPASLPESTPIPSSSPPPLSSPLPE----APQPKEEP 1562

Query: 448  PSPENTASSAP 458
            P PE  +S  P
Sbjct: 1563 PVPEAPSSGPP 1573



 Score = 34.3 bits (77), Expect = 0.73
 Identities = 33/117 (28%), Positives = 45/117 (38%), Gaps = 9/117 (7%)

Query: 304  VPPPT-PVRTSSIPVQE--AQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360
            VPPP  P+ ++SI  +    Q++     G      S         IRP   +    +P  
Sbjct: 1462 VPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGL---ESPVA 1518

Query: 361  DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLP-PPAPPLPPPAPPLPPAAPP 416
              PG   A  P  P     +S     +  PP + PLP  P P   PP P  P + PP
Sbjct: 1519 SLPGP--AEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPP 1573



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 18/47 (38%), Positives = 24/47 (51%), Gaps = 1/47 (2%)

Query: 196  ALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP 242
            ++ PP  L SP    P    PP  P A L P   P+P+ +PP  +SP
Sbjct: 1506 SIRPPGGLESPVASLPGPAEPPGLPPASL-PESTPIPSSSPPPLSSP 1551


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score =  105 bits (262), Expect = 3e-22
 Identities = 202/850 (23%), Positives = 275/850 (32%), Gaps = 156/850 (18%)

Query: 5    QTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGF-------DGIYYGDNR 57
            Q +      L G     TP+ SL  T P  +    AP  G+           G  +    
Sbjct: 1084 QVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAA 1143

Query: 58   FNTVSES-GTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVN 116
              T S +  TAT  A P   P    L L+           P +       EV     L +
Sbjct: 1144 ATTTSTTTATATTTAVPAPTPAPQRLILS-----------PDMQARLPSGEVVSIGQLAS 1192

Query: 117  GNLRLYSSVGDLRP-------------GQYGQDLLIPPPPPGP-------APGPPQDISE 156
               R  ++ G  +P             G   + L +  P P         + G    +  
Sbjct: 1193 LAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLIS 1252

Query: 157  PPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPP----PVLEALSPPHTLSSPSIPTPP 212
             P    L    +  P P P+ + P   PS  P P     P+     PP  +++  +    
Sbjct: 1253 QPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVK-- 1310

Query: 213  DFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEAT 272
              +    P   L P PP  PAP PP+   P  +  R                        
Sbjct: 1311 -IVVRQAPRDGLTPVPPLAPAPRPPSSGLPAVLNPR-----------------------P 1346

Query: 273  RASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIP------VQEAQEAPRK 326
              +P R P    G+A  P P P L  P    V  P+P  ++S P      +      P  
Sbjct: 1347 TLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSS 1406

Query: 327  EEGATKKAPSRLPLPPSFHIR---------PASQVYPDRAPEP-DCPGELKATAPASPRL 376
              G    A S +P+P S  +          P S   P   P     P     T P S  L
Sbjct: 1407 LPGP---ASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPL 1463

Query: 377  GQSQSQADERAGTPPPAPPLPP--PAPPLPPPAPPLPPA---------APPLPCAQKAAH 425
              S S         PP  P+ P  P PP   P+   P A         AP L  +Q   H
Sbjct: 1464 TVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGH 1523

Query: 426  P----------PAGFTKTPKSSSPALKP-----KPNPPSPENTASSAPVDWRDPSQMEKL 470
            P          P   +    + SP L P      P P +P    + A +     S  + L
Sbjct: 1524 PLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQAL 1583

Query: 471  RNELAAYLCGSRREDRFLSHRPGPTVAPQ---SKEGKKGPRLPEKETLLSLPAKDTPPGV 527
               LA     +  +   L+  P P +AP    +      P L   +T + + A  + PG 
Sbjct: 1584 ATPLAPM---AAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGT 1640

Query: 528  PEKSLGGSSLTETEAAPSLT---LPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKP 584
               S           APS T   LP+   +P   P+P+  Q         + A      P
Sbjct: 1641 SLASASPVPAPTPVLAPSSTQTMLPAP--VPSPLPSPASTQ---------TLALAPALAP 1689

Query: 585  SIGSLPPKPRLEGGRICENGA-DDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPP 643
            ++G   P   L  G     G      LS   A +L P   T   T SL P   LGP    
Sbjct: 1690 TLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVP---TPAQTLSLAPGPPLGPTQTL 1746

Query: 644  KATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTS 703
               P P + P + + PA     TL PA+   +   P +    T  PA      TL    +
Sbjct: 1747 SLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPA---PVPTLGPAAA 1803

Query: 704  QLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEAT---RLP-------TQGARSSAA 753
            Q +A     PA   + PASQ  S    A G  +P   T   RLP       T   RS   
Sbjct: 1804 QTLA---LAPA-STQSPASQASSLVVSASG-AAPLPVTMVSRLPVSKDEPDTLTLRSGPP 1858

Query: 754  FPPKTSPGGG 763
             PP T+   G
Sbjct: 1859 SPPSTATSFG 1868



 Score =  101 bits (252), Expect = 4e-21
 Identities = 201/848 (23%), Positives = 289/848 (34%), Gaps = 124/848 (14%)

Query: 134  GQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPPPLLLEPPPPP--SM 186
            G  L+    PPGP   PP   +       LPSP      ++ PP P L L+P PP    +
Sbjct: 1057 GPPLIPASRPPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRL 1116

Query: 187  APPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVG 246
            +P PPP   +L  P T+       P      +   A       P P PAP        + 
Sbjct: 1117 SPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQ 1176

Query: 247  TRLFPPGGVTKWKSDVALNGRQAEATRASPP-----------RSPAEPKGSALGPNPEP- 294
             RL P G V       +L  R       S P            + A+ +  A+G  P P 
Sbjct: 1177 ARL-PSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVG-QPRPL 1234

Query: 295  -----HLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHI-RP 348
                 HL            P   + I        P          PS  P P    +   
Sbjct: 1235 QRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLA 1294

Query: 349  ASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPP--- 405
            A+QV P      +  G +K     +PR        D     PP AP   PP+  LP    
Sbjct: 1295 ANQVPPTMV---NNTGVVKIVVRQAPR--------DGLTPVPPLAPAPRPPSSGLPAVLN 1343

Query: 406  PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTAS---SAPVDWR 462
            P P L P   P P    A  P      TP    P LK   + PSPE +AS   +AP+   
Sbjct: 1344 PRPTLTPGRLPTPTLGTARAP----MPTPTLVRPLLK-LVHSPSPEVSASAPGAAPLTIS 1398

Query: 463  DPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETL-LSLPAK 521
             P  +       A+            S  P P  +P +        +P   +L +S+P  
Sbjct: 1399 SPLHVPSSLPGPAS------------SPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTT 1446

Query: 522  -DTPPGVPEKSLGGSSLTETEAAP----SLTLPSVDYIPQDSPTPSVRQIRNELEARLSS 576
               P   P      + LT + + P    S+T P    +P     PS+            S
Sbjct: 1447 LPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSL----------APS 1496

Query: 577  AAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTS--LQPK 634
             A   A      L   P L   +          L  P + ++P  ++T+ P  S  L P 
Sbjct: 1497 GASPSASALTLGLATAPSLSSSQT----PGHPLLLAPTSSHVPGLNSTVAPACSPVLVPA 1552

Query: 635  AMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATS------- 687
            + L    P  + P PA    + L PA+     L  ATPL   + P T + A S       
Sbjct: 1553 SALASPFP--SAPNPAPAQASLLAPASSASQAL--ATPLAPMAAPQTAILAPSPAPPLAP 1608

Query: 688  ----------GPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSP 737
                       P +AS+ T +P       +   +  A     PA   V  PS  +     
Sbjct: 1609 LPVLAPSPGAAPVLASSQTPVPVMAPS--STPGTSLASASPVPAPTPVLAPSSTQTMLPA 1666

Query: 738  SEATRLPTQGARSSAAFPPKTSPG-GGEVPCL---------YKPHCHQSSLSREVAVVMP 787
               + LP+  +  + A  P  +P  GG  P             P   Q+      + ++P
Sbjct: 1667 PVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVP 1726

Query: 788  TLARGGAAGPGEPVEVKEPPGL-PAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAAR 846
            T A+  +  PG P+   +   L PA P A A P      H +T  +    S  +LL  A 
Sbjct: 1727 TPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLT--LAPASSSASLLAPAS 1784

Query: 847  QRA-----QKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKE 901
             +          ++G A  ++         S  ++ASS  +  S   P   T+V +LP  
Sbjct: 1785 VQTLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVS 1844

Query: 902  AEKDSPLT 909
             ++   LT
Sbjct: 1845 KDEPDTLT 1852



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 150/633 (23%), Positives = 211/633 (33%), Gaps = 95/633 (15%)

Query: 139  IPPPPPGPAPGPPQDISEPPGGSPLPSP---PSTAPPP----PPLLLEPPPPPSMAPPPP 191
            +P P P P P P    +  P   P+P     P +AP P    P  +L  PPPPS  PP  
Sbjct: 2436 VPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPPSQIPPCS 2495

Query: 192  PVLEALSPPHTLSSPSIPTPPD----FIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGT 247
                A +PP   + P   TPP      + P+ PL  L PP  P+ A     P        
Sbjct: 2496 S--PACTPPPACTPPPAHTPPPAQTCLVTPSSPL-LLGPPSVPISASVTNLPLGLRP-EA 2551

Query: 248  RLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPP 307
             L      +    ++A       ++ +  P     P    + P  E +L+   S    P 
Sbjct: 2552 ELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPS---APS 2608

Query: 308  TPVRTSSIPVQEAQEAPRKEEGATKKA-PSRLPLPPSFHIRPASQVYPDRAPEPDCPGEL 366
              +   SIP  + QEAP   EG T    P    LP         ++ P  A +      L
Sbjct: 2609 LTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPL 2668

Query: 367  KATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHP 426
            +A            S+    A TP  +P  P         AP    +A   P     A P
Sbjct: 2669 EA---------DRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARP 2719

Query: 427  PAGFTKTPKSSSPALKPKP-NPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRRED 485
            P   T            +P  PP P+       V  + P ++  +  E    L   RR+ 
Sbjct: 2720 PRRRTSADVEIRGQGTGRPGQPPGPK-------VLRKLPGRLVTVVEE--KELVRRRRQQ 2770

Query: 486  RFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPS 545
            R        T+ P   E    P  P   + +S P    P G P            EAAPS
Sbjct: 2771 R----GAASTLVPGVSETSASPGSPSVRS-MSGPESSPPIGGP-----------CEAAPS 2814

Query: 546  LTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGR------ 599
             +LP+    P   P  + R I  EL      + E      +   PP  +   GR      
Sbjct: 2815 SSLPT----PPQQPFIARRHI--ELGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKNR 2868

Query: 600  ---ICENGADDDKLSKPVAKN-----LPPQSTTLLPTTSLQPKAMLGP---AIPPKATPE 648
                   G D+   S    K      +P   T ++    L+P+ + GP      P   P 
Sbjct: 2869 SPADAGRGVDEAPSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPN 2928

Query: 649  PAIPPKATLWPATPPKATLGPATPLKATSG------------------PTTPLKATSGPA 690
            P + P        PPKA   P     +++G                  P  PL       
Sbjct: 2929 PLLSPVEKRRRGRPPKARDLPIPGTISSAGDGNSESRTQPPPHPSPLTPLPPLLVCPTAT 2988

Query: 691  IASTATTLPTTTSQLMAEKDSGPAGQPEKPASQ 723
            +A+T TT+  +TS    ++   P   P    SQ
Sbjct: 2989 VANTVTTVTISTSPPKRKRGRPPKNPPSPRPSQ 3021



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 144/558 (25%), Positives = 199/558 (35%), Gaps = 81/558 (14%)

Query: 305  PPPTPVRTSSIPVQEAQEAPRKEEGATKKAPS--RLPLPPSFHIRPASQVYPDRAPEPDC 362
            PPP P +   + V    +   K+EG T    +  R PL P   +RP     P+ + +P  
Sbjct: 983  PPPRP-KPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGP-VPVRPPPG--PELSAQPT- 1037

Query: 363  PGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPA-PPLPPPAPPLPPAAPPLPCAQ 421
            PG +    PAS  +  S           P  PPL P + PP P   PPL P +  LP  Q
Sbjct: 1038 PGPVPQVLPASLMVSAS-----------PAGPPLIPASRPPGPVLLPPLQPNSGSLP--Q 1084

Query: 422  KAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLR---------- 471
                P    + T +  +P L  KP PP+P   + + P     P     L+          
Sbjct: 1085 VLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPP-----PGSSSLLKPLTVPPGYTF 1139

Query: 472  NELAAYLCGSRREDRFLSHRPGPTVAPQS--KEGKKGPRLPEKETLLSLPAKDTPPGVPE 529
               AA    +       +  P PT APQ          RLP  E ++S+    +    P 
Sbjct: 1140 PPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGE-VVSIGQLASLAQRPV 1198

Query: 530  KSLGGSS-LTETEAAPSLTL--PSVDYIPQDSPTPSVRQIRNELEA-----RLSSAAEKE 581
             + GGS  LT       LTL    V  +    P P  R + + + A      +S  A   
Sbjct: 1199 ANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVA 1258

Query: 582  AKPSIGSLP---PKPRLEGGRICENGADDDKLSKPVAKNLPPQS-----------TTLLP 627
               ++   P   P   L         A    LS P+A N  P +               P
Sbjct: 1259 LIQAVAPTPGPTPVSVLPSSTPSTTPAPTG-LSLPLAANQVPPTMVNNTGVVKIVVRQAP 1317

Query: 628  TTSLQPKAMLGPAIPPKATPEPAI-PPKATLWPATPPKATLGPA---TPLKATSGPTTPL 683
               L P   L PA  P ++  PA+  P+ TL P   P  TLG A    P      P   L
Sbjct: 1318 RDGLTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKL 1377

Query: 684  KATSGPAIASTAT-TLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATR 742
              +  P ++++A    P T S  +    S P      PAS  +  P+ +      S    
Sbjct: 1378 VHSPSPEVSASAPGAAPLTISSPLHVPSSLPG-----PASSPMPIPNSSPLASPVSSTVS 1432

Query: 743  LPTQGARSSAAFPPKTSPGGGEVPC---LYKPHCHQSSLSREVAVVMPTLARGGAAGPGE 799
            +P   +   +   P T P     P    +  P    +S    +  V P LA    A PG 
Sbjct: 1433 VPLSSSLPISV--PTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGP 1490

Query: 800  PVEVKEPPGLPAKPPASA 817
            P     P G  A P ASA
Sbjct: 1491 P--SLAPSG--ASPSASA 1504



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 145/615 (23%), Positives = 215/615 (34%), Gaps = 128/615 (20%)

Query: 348  PASQVYPDRAPEPDCPGELKATAPAS-PRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP 406
            PA +  P  AP P       A+APA+ P L      A      P P   LP    P PPP
Sbjct: 2431 PARERVPRPAPRPR---PTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPP 2487

Query: 407  APPLPPAA-----PPLPCAQKAAH-PPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVD 460
               +PP +     PP  C    AH PP   T     SSP L   P+ P    + ++ P+ 
Sbjct: 2488 PSQIPPCSSPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPI-SASVTNLPLG 2546

Query: 461  WRDPSQM--EKLRNELAAYLCG-SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLS 517
             R  +++  + L +  +  L   +  E   LS  P   + P + E      LP  E  LS
Sbjct: 2547 LRPEAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVE-----ILPVSEKNLS 2601

Query: 518  LPAKDTPPGVPEKSLGGSSL---TETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARL 574
            L      P  P  +L   S+    E EA  S    ++  +P+    P      N LE   
Sbjct: 2602 L-----TPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPP 2656

Query: 575  SSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPK 634
            S+A+++         P +  LE  R  E      +L++       P+    L T  +   
Sbjct: 2657 SAASDE---------PLQEPLEADRTSE------ELTEAKTPTSSPEKPQELVTAEVAAP 2701

Query: 635  AMLGPAIPPKATPEPAIPPK------------ATLWPATPPKATLGPATPLKATSGPTTP 682
            +    A      P PA PP+             T  P  PP    GP    K      T 
Sbjct: 2702 STSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQPP----GPKVLRKLPGRLVTV 2757

Query: 683  LK---------------ATSGPAIASTATTLPTTTSQLMAEKDSGP--AGQPEKPASQEV 725
            ++               +T  P ++ T+ +  + + + M+  +S P   G  E   S  +
Sbjct: 2758 VEEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPIGGPCEAAPSSSL 2817

Query: 726  STPSQ------------ARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHC 773
             TP Q              G GSP         GA   A  PP      G  P   K + 
Sbjct: 2818 PTPPQQPFIARRHIELGVTGGGSPENG-----DGA-LLAITPPAVKRRRGRPP---KKNR 2868

Query: 774  HQSSLSREVAVVMPTLARGGAAGPGEPV----------EVKEPPGLPAKPPASAQPTDEL 823
              +   R V     +  +G   G  +PV           V EP  +P   P   QP    
Sbjct: 2869 SPADAGRGVDEAPSSTLKGKTNG-ADPVPGPETLIVADPVLEPQLIPGPQPLGPQP---- 2923

Query: 824  LRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIF 883
                     V R +P   LL+  ++ ++GR   A      +PG++   S   + +S+S  
Sbjct: 2924 ---------VHRPNP---LLSPVEKRRRGRPPKAR--DLPIPGTI---SSAGDGNSESRT 2966

Query: 884  HSQGTPNSFTVVPKL 898
                 P+  T +P L
Sbjct: 2967 QPPPHPSPLTPLPPL 2981



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 80/285 (28%), Positives = 99/285 (34%), Gaps = 57/285 (20%)

Query: 139  IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALS 198
            +P P P  AP   Q +   P  SPLPSP ST               ++AP   P L   S
Sbjct: 1648 VPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTL------------ALAPALAPTLGGSS 1695

Query: 199  PPHTLS----SPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGG 254
            P  TLS    +P  P P   +        L P    VP PA     +P        PP G
Sbjct: 1696 PSQTLSLGTGNPQGPFPTQTLS-------LTPASSLVPTPAQTLSLAPG-------PPLG 1741

Query: 255  VTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTF-PRSFKVPPPTPVRTS 313
             T           Q  +   +PP +PA P    +GP P   LT  P S       P   +
Sbjct: 1742 PT-----------QTLSLAPAPPLAPASP----VGPAPAHTLTLAPASSSASLLAP---A 1783

Query: 314  SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPAS 373
            S+       AP    G    A   L L P+    PASQ     +      G         
Sbjct: 1784 SVQTLTLSPAPVPTLGPA--AAQTLALAPASTQSPASQA---SSLVVSASGAAPLPVTMV 1838

Query: 374  PRLGQSQSQADE---RAGTPPPAPPLPPPAPPLPPPAPPLPPAAP 415
             RL  S+ + D    R+G P P         P P   PP PP +P
Sbjct: 1839 SRLPVSKDEPDTLTLRSGPPSPPSTATSFGGPRPRRQPPPPPRSP 1883



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 120/529 (22%), Positives = 174/529 (32%), Gaps = 87/529 (16%)

Query: 264  LNGRQAEATRASPPRSPAEPKGSALGPNPEP-HLTFPRSFKVPPPTPVRTSSIPVQEAQE 322
            ++  Q  +T   P  SPA  +     P P P   + P +     P PV   S PV  +  
Sbjct: 2415 ISAHQTRSTTTPPRCSPARERVPRPAPRPRPTPASAPAAIPALVPVPV---SAPVPISAP 2471

Query: 323  APRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQ 382
             P      T      LP PP     P SQ+ P     P C      T P           
Sbjct: 2472 NP-----ITILPVHILPSPP-----PPSQIPP--CSSPACTPPPACTPPP---------- 2509

Query: 383  ADERAGTPPPAPP-LPPPAPP--LPPPAPPLPPAAPPLP---------CAQKAAHPP--- 427
                A TPPPA   L  P+ P  L PP+ P+  +   LP         CAQ  A P    
Sbjct: 2510 ----AHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLE 2565

Query: 428  -AGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDR 486
             A    +  SS   + PK   P        +  +         L  E  +   G  +E  
Sbjct: 2566 LASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQE-- 2623

Query: 487  FLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTE-TEAAPS 545
                      AP S EG     LPE E L    ++     +P  +     L E  EA  +
Sbjct: 2624 ----------APDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEADRT 2673

Query: 546  LTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGA 605
                +    P  SP      +  E+ A  +S++   +        P  R     +   G 
Sbjct: 2674 SEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQ 2733

Query: 606  DDDKLSKP----VAKNLPPQSTTLLPTTSL--QPKAMLGPAIPPKATPEPAIPPKATLWP 659
               +  +P    V + LP +  T++    L  + +   G A              +TL P
Sbjct: 2734 GTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAA--------------STLVP 2779

Query: 660  ATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLM-----AEKDSGPA 714
                 +    +  +++ SGP +      GP  A+ +++LPT   Q        E      
Sbjct: 2780 GVSETSASPGSPSVRSMSGPESS-PPIGGPCEAAPSSSLPTPPQQPFIARRHIELGVTGG 2838

Query: 715  GQPEK--PASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPG 761
            G PE    A   ++ P+  R  G P +  R P    R     P  T  G
Sbjct: 2839 GSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPSSTLKG 2887



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 135/615 (21%), Positives = 196/615 (31%), Gaps = 148/615 (24%)

Query: 82   LPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPP 141
            LPL   E++GL +P  +  D+   + +    +                      + L   
Sbjct: 2642 LPLCVSESNGLELPPSAASDEPLQEPLEADRT---------------------SEELTEA 2680

Query: 142  PPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMA-------------- 187
              P  +P  PQ++      +P  S  +T+ P  P    PP   + A              
Sbjct: 2681 KTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQ 2740

Query: 188  PPPPPVLEAL-----------------------------SPPHTLSSPSIPTPPDFIPP- 217
            PP P VL  L                                 T +SP  P+      P 
Sbjct: 2741 PPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPE 2800

Query: 218  -APPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSD---VALNGRQAEATR 273
             +PP+       P    P PP           L   GG +    D   +A+     +  R
Sbjct: 2801 SSPPIGGPCEAAPSSSLPTPPQQPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRRR 2860

Query: 274  ASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSI---PVQEAQEAPRKEEGA 330
              PP+    P  +  G +  P  T         P P   + I   PV E Q  P  +   
Sbjct: 2861 GRPPKKNRSPADAGRGVDEAPSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLG 2920

Query: 331  TKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTP 390
             +  P   P P    +    +  P +A +   PG + +        G S+S+      T 
Sbjct: 2921 PQ--PVHRPNPLLSPVEKRRRGRPPKARDLPIPGTISSAGD-----GNSESR------TQ 2967

Query: 391  PPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALK---PKPNP 447
            P  PP P P  PL           PPL     A       T T  +S P  K   P  NP
Sbjct: 2968 P--PPHPSPLTPL-----------PPLLVCPTATVANTVTTVTISTSPPKRKRGRPPKNP 3014

Query: 448  PSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGP 507
            PSP    S  PV  RD + +      L +   G RR+ +      G   +  S   + G 
Sbjct: 3015 PSPR--PSQLPVLDRDSTSV------LESCGLGRRRQPQ------GQGESEGSSSDEDGS 3060

Query: 508  RLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIR 567
            R   +   L L A+    G+  +  GGS +                         V  I+
Sbjct: 3061 RPLTRLARLRLEAE----GMRGRKSGGSMV-------------------------VAVIQ 3091

Query: 568  NELEARLSSAAEKEAKPSIGSLPPK---PRLEGGRICENGADDDKLSKPVAKNLPPQSTT 624
            ++L+   S     E  P + SL PK    RL  G +     + +KL +  A      S  
Sbjct: 3092 DDLDLADSGPGGLELTPPVVSLTPKLRSTRLRPGSLVP-PLETEKLPRKRAGAPVGGSPG 3150

Query: 625  LLPTTSLQPKAMLGP 639
            L     LQP + LGP
Sbjct: 3151 LAKRGRLQPPSPLGP 3165



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 115/495 (23%), Positives = 164/495 (33%), Gaps = 104/495 (21%)

Query: 711  SGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYK 770
            S  A  PE+P ++       AR E   +  T + +     S   PP+ SP    VP    
Sbjct: 2382 SKKAKAPERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPRCSPARERVP---- 2437

Query: 771  PHCHQSSLSREVAVVMPTLARGGAAGPG-EPVEVKEPPGLPAKPPASAQPTDELLRHPVT 829
                     R      PT A   AA P   PV V  P  + A  P +  P   L   P  
Sbjct: 2438 ---------RPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPP 2488

Query: 830  GEVVERGSP--------------------MALLLAARQRAQKGRSVGAALGRSSLPGSLR 869
             ++    SP                      L+  +        SV  +   ++LP  LR
Sbjct: 2489 SQIPPCSSPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLR 2548

Query: 870  DHSH---QAEASSDSI---FHSQGTPNSFTVVPKLPKEAEKDSPLTTEI--PNKWGPRLG 921
              +    QA AS +S+     +    +S ++VP  PK+     P+  EI   ++    L 
Sbjct: 2549 PEAELCAQALASPESLELASVASSETSSLSLVP--PKDL---LPVAVEILPVSEKNLSLT 2603

Query: 922  RDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSS------PPS------ 969
              A    L         E +AP + E    + LP+G  LP   S       PPS      
Sbjct: 2604 PSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEP 2663

Query: 970  -------------------PSNKREEEEEEFNFEVIPPPPEFS--NDPEPPAPALQYLGR 1008
                               P++  E+ +E    EV  P    S  + PE P+PA      
Sbjct: 2664 LQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPA------ 2717

Query: 1009 QSSPPRNNYS---DLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLE------RFSGGGR 1059
               PPR   S   ++R      PG PP     R   G         E      +  G   
Sbjct: 2718 --RPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAAS 2775

Query: 1060 SLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPR 1119
            +L+     V E    PG P   + RS+S P    P  GGP     +S+   PP      R
Sbjct: 2776 TLVPG---VSETSASPGSP---SVRSMSGPES-SPPIGGPCEAAPSSSLPTPPQQPFIAR 2828

Query: 1120 LSLEGAARGAAEAKH 1134
              +E    G    ++
Sbjct: 2829 RHIELGVTGGGSPEN 2843



 Score = 32.0 bits (71), Expect = 3.6
 Identities = 37/148 (25%), Positives = 56/148 (37%), Gaps = 25/148 (16%)

Query: 679 PTTPLKATSGPAI-ASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSP 737
           P T  KA S P + +S+A + P   +  + ++D     Q ++    E +   + + EG+ 
Sbjct: 254 PLTSSKAGSSPCLGSSSAASSPPPPASRLDDEDGDFQPQEDEEEDDEETIEVEEQQEGND 313

Query: 738 SEATRLPTQGARSSAAFP--------PKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTL 789
           +EA R   +  R     P        P     G   P    P  H S  +R+        
Sbjct: 314 AEAQRREIELLRREGELPLEELLRSLPPQLLEGPSSPS-QTPSSHDSD-TRD-------- 363

Query: 790 ARGGAAGPGEPVEVKEPPGLPAKPPASA 817
                 GP E  E + P  L  KPP SA
Sbjct: 364 ------GPEEGAEEEPPQVLEIKPPPSA 385



 Score = 30.8 bits (68), Expect = 8.0
 Identities = 37/150 (24%), Positives = 51/150 (34%), Gaps = 13/150 (8%)

Query: 83   PLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPP 142
            PL   +   LA   P  P          T +L   +    SS   L P       L P P
Sbjct: 1739 PLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPAS----SSASLLAPASVQTLTLSPAP 1794

Query: 143  PPGPAPGPPQDISEPPGGSPLPSPPSTA-------PPPPPLLLEPPPPPSMAPPPPPVLE 195
             P   P   Q ++  P  +  P+  +++         P P+ +    P S   P    L 
Sbjct: 1795 VPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLR 1854

Query: 196  A--LSPPHTLSSPSIPTPPDFIPPAPPLAF 223
            +   SPP T +S   P P    PP P   F
Sbjct: 1855 SGPPSPPSTATSFGGPRPRRQPPPPPRSPF 1884


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score =  103 bits (257), Expect = 1e-21
 Identities = 118/456 (25%), Positives = 168/456 (36%), Gaps = 73/456 (16%)

Query: 134 GQDLLIPPPPPGPAPGPPQD------ISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMA 187
           G ++ +P P P   P PP +       S     +  PSP +   P     L+ P   S++
Sbjct: 175 GTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 234

Query: 188 PPPPPVLE-ALSPPHTLSSPSIPT--------------PPDFIPP----APPLAFLAPPP 228
               P+   A S P    +P  P               PP   PP    AP L  L+  P
Sbjct: 235 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSP 294

Query: 229 PPVPAP-APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSA 287
              P+P APP+P++P ++ T   PP      ++  +L     +AT +  P  P  P  + 
Sbjct: 295 LATPSPSAPPSPSAPPSLQTLPSPPATPPS-QATTSLGSPTLQATHSFLPSPPLSPLATP 353

Query: 288 LGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIR 347
                            PP  P   +  P+Q    AP     +   +P   P P + +  
Sbjct: 354 -----------------PPQAPPALALPPLQ----APPSPPASPPLSPLATPSPQAPNAL 392

Query: 348 PASQVYPDRAPEPDCPGELKATAPASPRLGQSQ---SQADERAGTPP-PAPPLPPPAPPL 403
               +    +P P  P +   + PASP +  S    SQA      PP   PP PP +PP+
Sbjct: 393 AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM 452

Query: 404 PPPAPPLPPAAPPL--PCAQKAAHPPAGFTKTPKSSSPALKPKPNPP---------SPEN 452
            P A P P A PPL  P  Q A  PP      P  ++P L+  P+PP         SP  
Sbjct: 453 SPSATPPPQAPPPLAAPPLQLAKPPPQA---PPALATPPLQALPSPPASFPGQAPFSPSA 509

Query: 453 TASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEK 512
           +   +P+    P     L   L              + R  PT  P +     GPRL   
Sbjct: 510 SLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT--SVSGPRL--- 564

Query: 513 ETLLSLPAKDTPPG-VPEKSLGGSSLTETEAAPSLT 547
            TL   P    PP   P  +L G  L    ++ + T
Sbjct: 565 -TLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATST 599



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 199/797 (24%), Positives = 262/797 (32%), Gaps = 189/797 (23%)

Query: 130 PGQYGQDLLIPPPPPGPAPGPP-----------------QDISEPPGGSPLPSPPSTAPP 172
           P      LL P PP  P P PP                 + ++E  GG    + P +AP 
Sbjct: 17  PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76

Query: 173 PPPLLLEPPP--------PPSMAPPPPPVLE------------------ALSPPHTLS-- 204
             P     PP        PP+    P PV                     +S   T++  
Sbjct: 77  AGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARG 136

Query: 205 -----------------SPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGT 247
                              S PTP    P     +  A     +P PAP A   P T G 
Sbjct: 137 KATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGP 196

Query: 248 R----------LFPPGGVTKWKSDVALNGRQAEATR-----ASPPRSPAEPKGSALG-PN 291
           R             P    + +   A  G Q  A+R     A+P  SPA    SA G P 
Sbjct: 197 RKSVSSASEHSTTEPSPAAR-RRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPR 255

Query: 292 PEPHLTFPR-----SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHI 346
              H + P+     + + P  TP R  + P       P         +PS    PPS   
Sbjct: 256 APAHPSQPKPKGLQALRPPQVTPPRKDAAPAL----GPLSSSPLATPSPS---APPSPSA 308

Query: 347 RPASQVYPDRAPEPDCPGELKATAPASPRLGQSQS-----QADERAGTPPPAPP---LPP 398
            P+ Q  P     P  P     T+  SP L  + S          A  PP APP   LPP
Sbjct: 309 PPSLQTLPS---PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP 365

Query: 399 -PAPPLPPPAPPLPPAAPPLPCAQKA----------AHPPAGFTKTPKS--SSPALKPKP 445
             APP PP +PPL P A P P A  A          + PP+   + P S  +SP + P  
Sbjct: 366 LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA 425

Query: 446 NPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKK 505
            PPS    + +AP     PS         +A               P P  AP  +  K 
Sbjct: 426 TPPSQAPPSLAAPPLQVPPSPPASPPMSPSA---------TPPPQAPPPLAAPPLQLAKP 476

Query: 506 GPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQ 565
            P+ P        PA  TPP     S   S   +   +PS +LP     P  +P P    
Sbjct: 477 PPQAP--------PALATPPLQALPSPPASFPGQAPFSPSASLP---MSPLATPPPQAPP 525

Query: 566 IRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKP----VAKNLPPQ 621
           +   L A L             S P  P L+  R       D  +S P         PP 
Sbjct: 526 V---LAAPLLQVPP--------SPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPP 574

Query: 622 STTLLPTTSLQPKAMLGPAIPPKATPE--------------PAIPPKATLWPATPPKATL 667
             +  P+++L    + G +    +TPE               + PP A L    P   + 
Sbjct: 575 PPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSR 634

Query: 668 GPATPLKATSGPTTPL--KATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEV 725
           GPA PL     P  PL     +GP  A    T+  T          GP          E 
Sbjct: 635 GPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYET---------EGP----------ES 675

Query: 726 STPSQARGEGSPSEATR--LPTQGARSSAAFPPKTSPGGGEVPC-LYKPHCHQSSLSREV 782
           +TP+    +  PS  T       GA + A+         GE+P    +    Q  LSR +
Sbjct: 676 ATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTL 735

Query: 783 AVVMPTLARGGA-AGPG 798
            +     A GG+  GPG
Sbjct: 736 LLAAAEGAAGGSGGGPG 752



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 134/489 (27%), Positives = 174/489 (35%), Gaps = 59/489 (12%)

Query: 129 RPGQYGQDLLIPPP--PP----GPAPGPPQDISEPPGGSPLPS-------PPSTAPPPPP 175
           +P   G   L PP   PP     PA GP   +S  P  +P PS       PPS    P P
Sbjct: 262 QPKPKGLQALRPPQVTPPRKDAAPALGP---LSSSPLATPSPSAPPSPSAPPSLQTLPSP 318

Query: 176 LLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPA 235
               P  PPS A              +L SP++     F+ P+PPL+ LA PPP  P PA
Sbjct: 319 ----PATPPSQATT------------SLGSPTLQATHSFL-PSPPLSPLATPPPQAP-PA 360

Query: 236 ---PPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAE-----PKGSA 287
              PP  A P    +    P      ++  AL     +A  + PP  P +     P    
Sbjct: 361 LALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 420

Query: 288 LGPNPEPHLTFPRSFKVPP--PTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFH 345
           + P+  P    P S   PP    P   +S P+  +   P +        P +L  PP   
Sbjct: 421 VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPP-- 478

Query: 346 IRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPP 405
             P +   P     P  P      AP SP    S S       TPPP  P    AP L  
Sbjct: 479 QAPPALATPPLQALPSPPASFPGQAPFSP----SASLPMSPLATPPPQAPPVLAAPLL-- 532

Query: 406 PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPP---SPENTASSAPVDWR 462
             PP PPA+P L   ++   P    + +    + AL P P PP   SP +T S   +   
Sbjct: 533 QVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGH 592

Query: 463 DPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLP-EKETLLSLPAK 521
             S       EL  Y  G                A       +GP  P         P  
Sbjct: 593 S-SSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLP 651

Query: 522 DTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKE 581
             P   P  + G  ++ ETE   S T       P  SP  S  +      A  SS + K+
Sbjct: 652 WPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQ 711

Query: 582 AKPSIGSLP 590
           A+  +G LP
Sbjct: 712 AR--LGELP 718



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 190/719 (26%), Positives = 247/719 (34%), Gaps = 121/719 (16%)

Query: 146 PAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSS 205
           PA   P  ++  P GSP P PP T     P  L            P    A         
Sbjct: 17  PAARAPGLLTPRPPGSPRPPPPVT-----PAALRVLGAAGAVGRKPLAERAGGIGGATIP 71

Query: 206 PSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVG--TRLFPPG--GVTKWKSD 261
            S P         PP +      PP    +P   +SP      TR  P G  G+     +
Sbjct: 72  ESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEE 131

Query: 262 VALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQ 321
               G+  EA + S   + A    S  GP P            P P   R S        
Sbjct: 132 TVARGKATEAPKRSALSAGARRDTS--GPTP----------GTPSPAMARRS-------- 171

Query: 322 EAPRKEEGATKKAPSRLPLPPSFHIRPA-SQVYPDRAPEPDCPGELKATA------PASP 374
            A   E G  + APS  P PP+   R + S        EP      + +A      PAS 
Sbjct: 172 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 231

Query: 375 RLGQSQSQADERAGTPPPAPPLP-PPAPPLPPPAPPLPPAAPP-LPCAQKAAHPPAGFTK 432
            L  S +     A + P A   P  PA P  P    L    PP +   +K A P  G   
Sbjct: 232 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG--- 288

Query: 433 TPKSSSPALKPKPN-PPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHR 491
            P SSSP   P P+ PPSP     SAP   +            A    GS       S  
Sbjct: 289 -PLSSSPLATPSPSAPPSP-----SAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFL 342

Query: 492 PGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSV 551
           P P ++P +      P+ P    L  L A  +PP  P  S   +   +   A ++ L   
Sbjct: 343 PSPPLSPLA---TPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQA 399

Query: 552 DYIPQDSPTPSVRQIRNELEARLSSAA--EKEAKPSIGS----LPPKPRLEGGRICENGA 605
            + P  SP P            +S +A    +A PS+ +    +PP P      +  +  
Sbjct: 400 PFSPPPSP-PVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPP-ASPPMSPSAT 457

Query: 606 DDDKLSKPVA------KNLPPQSTTLLPTTSLQ-----PKAMLGPA---------IPPKA 645
              +   P+A         PPQ+   L T  LQ     P +  G A         + P A
Sbjct: 458 PPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLA 517

Query: 646 TPEPAIPPKATL----WPATPPKATLGPATPLKATSGPTTPLKATSGPAIA-STATTLPT 700
           TP P  PP         P +PP +    A     T GP T   + SGP +  + A   P 
Sbjct: 518 TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT---SVSGPRLTLALAPGPPP 574

Query: 701 TTSQLMAEKDSGP--AGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKT 758
             S+  +   SGP  AG     +S   STP + RG  S  E           +AA PP  
Sbjct: 575 PPSRSPSSTLSGPDLAGH----SSSATSTPEELRGYDSGPEG---------GAAASPP-- 619

Query: 759 SPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASA 817
                  P      CH ++ SR  A   P LA  GA  PG P+     P  PA  P SA
Sbjct: 620 -------PDAELAACHPAAWSRGPA---PPLAFRGA--PGAPL-----PWPPATGPGSA 661



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 206/875 (23%), Positives = 279/875 (31%), Gaps = 187/875 (21%)

Query: 356  RAPEPDCPGELKATAPASPR------------LGQS----QSQADERAGTPPPAPPLPPP 399
            R P    PG L    P SPR            LG +    +    ERAG    A  +P  
Sbjct: 15   RTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGAT-IPES 73

Query: 400  APPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPV 459
            AP   P     PPA+     A  A +   G   +P  +S   +P P        ++   V
Sbjct: 74   APRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETV 133

Query: 460  DWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLP 519
                 ++  K R+ L+A   G+RR+        GPT    S    +  R    E  L  P
Sbjct: 134  ARGKATEAPK-RSALSA---GARRDTS------GPTPGTPSPAMARRSRAAGTEVGLPRP 183

Query: 520  AKDTPPGVP----EKSLGGSSL-TETEAAPSLTL-PSVDYIPQDSPTPSVRQIRNELEAR 573
            A    P  P     KS+  +S  + TE +P+    PS     Q   + S+      L + 
Sbjct: 184  APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 243

Query: 574  LSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQP 633
              S       P   + P +P+ +G +                   PPQ T   P     P
Sbjct: 244  ARSGPSARGTPRAPAHPSQPKPKGLQALR----------------PPQVTP--PRKDAAP 285

Query: 634  KAMLGP-AIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATS----- 687
               LGP +  P ATP P+ PP     P+ PP     P+ P    S  TT L + +     
Sbjct: 286  A--LGPLSSSPLATPSPSAPPS----PSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH 339

Query: 688  ----GPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRL 743
                 P ++  AT  P     L       P   P  P    ++TPS       P     L
Sbjct: 340  SFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPS-------PQAPNAL 392

Query: 744  PTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEV 803
                 ++  + PP         P +  P    +S     +   P+ A    A P  P++V
Sbjct: 393  AVHLLQAPFSPPPS--------PPVQAPFSPPASPPVSPSATPPSQAPPSLAAP--PLQV 442

Query: 804  KEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSS 863
              PP  PA PP S   T                +P  L     Q A+       AL    
Sbjct: 443  --PPSPPASPPMSPSATPP------------PQAPPPLAAPPLQLAKPPPQAPPALATPP 488

Query: 864  LPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRD 923
            L         QA  S  + F  Q         P  P  +   SPL T             
Sbjct: 489  L---------QALPSPPASFPGQA--------PFSPSASLPMSPLAT------------- 518

Query: 924  AEGTELSRRHNWTKPEPQAPVAWE----RVAPSNLPQGHPLPKSFSSPPSPSNKREEEEE 979
                          P PQAP        +V PS  P   P  ++   PP+P         
Sbjct: 519  --------------PPPQAPPVLAAPLLQVPPS--PPASPTLQAPRRPPTPGPDTSVSGP 562

Query: 980  EFNFEVIP-PPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQL---PNAGPGAPPA-- 1033
                 + P PPP  S  P          G  SS   +   +LR     P  G  A P   
Sbjct: 563  RLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT-STPEELRGYDSGPEGGAAASPPPD 621

Query: 1034 --------LGFSRFPAGA-RYAGAGGLER----FSGGGRSLIKKRLYVGE------PHRG 1074
                      +SR PA    + GA G        +G G +     +Y  E      P  G
Sbjct: 622  AELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 681

Query: 1075 ---PGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAP-------RLSLEG 1124
               PG   G +G   ++    G     P+  R+   G  P G L A        R  L  
Sbjct: 682  ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARL---GELPLGALQASVVQHLLSRTLLLA 738

Query: 1125 AARGAAEAKHKAPGSADYGFAPAAGRSPYTTTRYG 1159
            AA GAA      PG A+ G      R+  +    G
Sbjct: 739  AAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELG 773



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 123/522 (23%), Positives = 169/522 (32%), Gaps = 97/522 (18%)

Query: 376 LGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPK 435
           +   + +A   A    PA   P    P PP +P  PP  P  P A +         + P 
Sbjct: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPP--PVTPAALRVLGAAGAVGRKPL 58

Query: 436 SS-----SPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSH 490
           +        A  P+  P +     S  P   R   +    +N     +    R     + 
Sbjct: 59  AERAGGIGGATIPESAPRAGPTRTSRPPASGRG-ERAPPAKNTSPGPVSSPGRASG--TT 115

Query: 491 RPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTP-----------------PGVPEKSLG 533
           RPGP        G+KG R+  +ET+    A + P                 PG P  ++ 
Sbjct: 116 RPGPL-------GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMA 168

Query: 534 -GSSLTETEAAPSLTLPSV-DYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPP 591
             S    TE       PS     P + P  SV           S AA +  +PS G    
Sbjct: 169 RRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR--RPSAGGGLQ 226

Query: 592 KPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPK----------------- 634
           +P     R   + A    LS P       + T   P    QPK                 
Sbjct: 227 RP---ASRSLSSSA--TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRK 281

Query: 635 ---AMLGP-AIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATS--- 687
                LGP +  P ATP P+ PP     P+ PP     P+ P    S  TT L + +   
Sbjct: 282 DAAPALGPLSSSPLATPSPSAPPS----PSAPPSLQTLPSPPATPPSQATTSLGSPTLQA 337

Query: 688 ------GPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPS------------ 729
                  P ++  AT  P     L       P   P  P    ++TPS            
Sbjct: 338 THSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLL 397

Query: 730 QARGEGSPSEATRL----PTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVV 785
           QA     PS   +     P     S +A PP  +P     P L  P    +S     +  
Sbjct: 398 QAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSAT 457

Query: 786 MPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHP 827
            P  A    A P  P+++ +PP  P  PPA A P  + L  P
Sbjct: 458 PPPQAPPPLAAP--PLQLAKPP--PQAPPALATPPLQALPSP 495


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score =  103 bits (256), Expect = 1e-21
 Identities = 127/453 (28%), Positives = 172/453 (37%), Gaps = 62/453 (13%)

Query: 208 IPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP----HTVGTRLFPPGGVTKWKSDVA 263
           +P PP   PP PPL    PPPPP+ AP PP P++P     T   R   P G +   +D+ 
Sbjct: 1   MPVPP---PPPPPLP---PPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQ 54

Query: 264 LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT--PVRTSSIPVQEAQ 321
              R  + T+ +   +P     S+ G N E   +        PPT   +     PV    
Sbjct: 55  QGTRLRKVTQINDRSAPQIE--SSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPA 112

Query: 322 EAPRKEEGATKKAP-SRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQ 380
                  G T + P SR P P              R P     G L    PASPRLG + 
Sbjct: 113 GQRDVAGGKTGQGPGSRAPSP--------------RLPNKTISGPL--IPPASPRLGNT- 155

Query: 381 SQADERAGTPPPAPPLPPPAPPLPPPAPP-LPPAAP-PLPCAQKAAHPPAGFTK-TPKSS 437
           S+A   A T PP P +P P PP PPP PP LPP  P   P       PP   TK      
Sbjct: 156 SEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVV 215

Query: 438 SPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVA 497
           +P +   P PP P    +  P+        + ++ +LA                P P + 
Sbjct: 216 APPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPP-------IPPPLPLLP 268

Query: 498 PQSKEGKKG-PRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQ 556
           P    G K  P  P ++          PP  P      +S +   + P+  LP V+   +
Sbjct: 269 PCGYPGLKAEPASPAQDA-------QEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSE 321

Query: 557 DSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPP--KPRLEGGRICENGADDDKLSKPV 614
             P    +    +   + + A    A P+    PP  +P L+  R    GA   KL+ P 
Sbjct: 322 TPPPLPPKSPSFQAPPQKAGAQALPAPPA----PPGSQPFLQKKRHGRPGAGGGKLNPPP 377

Query: 615 AKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATP 647
           A   PP  +   PTT L  K+    A  P   P
Sbjct: 378 A---PPARS---PTTELSSKSQQATAWTPTQQP 404



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 102/326 (31%), Positives = 117/326 (35%), Gaps = 92/326 (28%)

Query: 142 PPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPH 201
           PP  P  G   +       +P P P   APPPP     PPPPP   PPP P    +  P 
Sbjct: 146 PPASPRLGNTSEAHGAARTAP-PRPNVPAPPPPT----PPPPPPPLPPPLPSSSPIKTP- 199

Query: 202 TLSSPSIPTPPDFIPP-APPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKS 260
            L SP  P     +P  APP+    PPPPP P P PP             PP  V    S
Sbjct: 200 -LVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPP-----------LPPASVL---S 244

Query: 261 DVALNGRQAEATRAS-PPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQE 319
           D A+  + A       PP  P  P     G   EP                   + P Q+
Sbjct: 245 DKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEP-------------------ASPAQD 285

Query: 320 AQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQS 379
           AQE P         AP   PLPP     P                  +A+ PA P  G +
Sbjct: 286 AQEPP---------APPP-PLPPYASCSP------------------RASLPAPPLPGVN 317

Query: 380 QSQADERAGTPPPAPPLPPP--APPLPP-----PAPPLPPAAPPLPCAQKAAHPPAGFTK 432
            S       TPPP PP  P   APP        PAPP PP + P    ++   P AG  K
Sbjct: 318 SSSE-----TPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGK 372

Query: 433 TPKSSSPALKPKPNPP--SPENTASS 456
                   L P P PP  SP    SS
Sbjct: 373 --------LNPPPAPPARSPTTELSS 390



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 88/292 (30%), Positives = 112/292 (38%), Gaps = 73/292 (25%)

Query: 138 LIPPPPP-----GPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPP 192
           LIPP  P       A G  +  + P    P P PP+  PPPPPL   PPP PS +P   P
Sbjct: 144 LIPPASPRLGNTSEAHGAART-APPRPNVPAPPPPTPPPPPPPL---PPPLPSSSPIKTP 199

Query: 193 VLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTV------- 245
           ++   SPP  L+  ++P      PP P     APPPPP P P  P P  P +V       
Sbjct: 200 LV---SPPGPLTKGNLPV---VAPPVP----CAPPPPPPPPPPTPPPLPPASVLSDKAVK 249

Query: 246 -------------GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP 292
                           L PP G    K++ A   + A+   A PP  P     S     P
Sbjct: 250 PQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLP 309

Query: 293 EPHLT-FPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQ 351
            P L     S + PPP P ++ S       +AP ++ GA       LP PP+    P SQ
Sbjct: 310 APPLPGVNSSSETPPPLPPKSPSF------QAPPQKAGA-----QALPAPPA---PPGSQ 355

Query: 352 VYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPL 403
            +            L+      P  G  +         PPPAPP   P   L
Sbjct: 356 PF------------LQKKRHGRPGAGGGKL-------NPPPAPPARSPTTEL 388



 Score = 77.4 bits (189), Expect = 7e-14
 Identities = 79/294 (26%), Positives = 100/294 (34%), Gaps = 82/294 (27%)

Query: 141 PPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPP----------PPLLLEPPPPPSMAPPP 190
           PPPP P P PP      P  SP+ +P  + P P          PP+   PPPPP   PPP
Sbjct: 174 PPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPP---PPP 230

Query: 191 PPVLEALSPPHTLSSPSIPTP--PDFIPPAPPLAFLAPP-------------------PP 229
           PP    L P   LS  ++     P  +PP PP   L PP                   PP
Sbjct: 231 PPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPP 290

Query: 230 PVPAPAPP-APASPHTVGTRLFPPGGVTKWKSDVALNGR----QAEATRASPPRSPAEPK 284
             P P PP A  SP         PG  +  ++   L  +    QA   +A     PA P 
Sbjct: 291 APPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPA 350

Query: 285 GSALGPNPEPHLTFPRSFKV--------PPPTPVRTSSIPVQEAQEAPRKEEGATKKAPS 336
                P  +P L   R  +         PPP P   S        E   K + AT   P+
Sbjct: 351 P----PGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP-----TTELSSKSQQATAWTPT 401

Query: 337 RLP--------------------------LPPSFHIRPASQVYPDRAPEPDCPG 364
           + P                           PP    +P  ++YP + P    PG
Sbjct: 402 QQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPG 455



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 121/508 (23%), Positives = 157/508 (30%), Gaps = 121/508 (23%)

Query: 394 PPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENT 453
           P  PPP PPLPPP PPL    PP P A                          PP   +T
Sbjct: 2   PVPPPPPPPLPPPPPPLGAPPPPPPSA--------------------------PPVSTDT 35

Query: 454 ASSAPVDWRDPSQMEKLRNELAAYLCGSR-REDRFLSHRPGPTVAPQSKEGKKGPRLPEK 512
           +S    D +  S +      LA    G+R R+   ++ R  P +       K+G      
Sbjct: 36  SSLRRADPKGRSAL------LADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANT 89

Query: 513 ETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEA 572
                     TPP + +   GG                          P +R       A
Sbjct: 90  R------GASTPPTLGDLFAGGF-------------------------PVLRP------A 112

Query: 573 RLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQ 632
                A  +     GS  P PRL    I          S P+   +PP S  L  T+   
Sbjct: 113 GQRDVAGGKTGQGPGSRAPSPRLPNKTI----------SGPL---IPPASPRLGNTSEAH 159

Query: 633 PKAMLGPA-----IPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTT----PL 683
             A   P       PP  TP P  PP     P++ P       TPL +  GP T    P+
Sbjct: 160 GAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSP-----IKTPLVSPPGPLTKGNLPV 214

Query: 684 KATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQA--RGEGSPSEAT 741
            A   P         P  T          P   P    S +   P  A       P    
Sbjct: 215 VAPPVPCAPPPPPPPPPPTP---------PPLPPASVLSDKAVKPQLAPLHLPPIPPPLP 265

Query: 742 RLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPV 801
            LP  G     A P   +    E P    P    +S S   ++  P L       PG   
Sbjct: 266 LLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPL-------PGVNS 318

Query: 802 EVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGR 861
             + PP LP K P+   P  +     +       GS   L     Q+ + GR  GA  G+
Sbjct: 319 SSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFL-----QKKRHGRP-GAGGGK 372

Query: 862 SSLPGSLRDHSHQAEASSDSIFHSQGTP 889
            + P +    S   E SS S   +  TP
Sbjct: 373 LNPPPAPPARSPTTELSSKSQQATAWTP 400



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 68/270 (25%), Positives = 90/270 (33%), Gaps = 39/270 (14%)

Query: 800  PVEVKEPPGLPAKPPA-SAQPTDELLRHPVTGEV--VERGSPM--ALLLAARQRAQKGRS 854
            PV    PP LP  PP   A P       PV+ +   + R  P   + LLA  Q+  + R 
Sbjct: 2    PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRK 61

Query: 855  VGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVV-----PKLPKEAEKD---- 905
            V     RS+ P          E    +      TP +   +     P L    ++D    
Sbjct: 62   VTQINDRSA-PQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGG 120

Query: 906  ---------SPLTTEIPNKW---------GPRLGRDAEGTELSR----RHNWTKPEPQAP 943
                     +P +  +PNK           PRLG  +E    +R    R N   P P  P
Sbjct: 121  KTGQGPGSRAP-SPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP 179

Query: 944  VAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDP-EPPAPA 1002
                   P  LP   P+     SPP P  K             PPPP     P  PP P 
Sbjct: 180  PPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPP 239

Query: 1003 LQYLGRQSSPPRNNYSDLRQLPNAGPGAPP 1032
               L  ++  P+     L  +P   P  PP
Sbjct: 240  ASVLSDKAVKPQLAPLHLPPIPPPLPLLPP 269


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score =  101 bits (251), Expect = 5e-21
 Identities = 112/420 (26%), Positives = 154/420 (36%), Gaps = 68/420 (16%)

Query: 158 PGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPP 217
           P     P  P+    P P  L+   PP + PP      AL P   LSS  + TP     P
Sbjct: 257 PSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP---LSSSPLATPS----P 309

Query: 218 APPLAFLAPPPPPV-------------PAP-APPAPASPHTVGTRLFPPGGVTKWKSDVA 263
           +  L   APP  P              P P APP+P++P ++ T   PP      ++  +
Sbjct: 310 SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPS-QATTS 368

Query: 264 LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA 323
           L     +AT +  P  P  P  +                  PP  P   +  P+Q    A
Sbjct: 369 LGSPTLQATHSFLPSPPLSPLATP-----------------PPQAPPALALPPLQ----A 407

Query: 324 PRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQ--- 380
           P     +   +P   P P + +      +    +P P  P +   + PASP +  S    
Sbjct: 408 PPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPP 467

Query: 381 SQADERAGTPP-PAPPLPPPAPPLPPPAPPLPPAAPPL--PCAQKAAHPPAGFTKTPKSS 437
           SQA      PP   PP PP +PP+ P A P P A PPL  P  Q A  PP      P  +
Sbjct: 468 SQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA---PPALA 524

Query: 438 SPALKPKPNPP---------SPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFL 488
           +P L+  P+PP         SP  +   +P+    P     L   L              
Sbjct: 525 TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQ 584

Query: 489 SHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG-VPEKSLGGSSLTETEAAPSLT 547
           + R  PT  P +     GPRL    TL   P    PP   P  +L G  L    ++ + T
Sbjct: 585 APRRPPTPGPDT--SVSGPRL----TLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATST 638



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 131/498 (26%), Positives = 170/498 (34%), Gaps = 60/498 (12%)

Query: 141 PPPPGPAPGPPQDISEP-----PGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLE 195
           P P G     P  ++ P     P   PL S P   P P   L    PP   A P    L 
Sbjct: 272 PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLT 331

Query: 196 A-LSPPHTLSSPS---------IPTPPDFIP-------------------PAPPLAFLAP 226
             L+ P  L+ PS         +P+PP   P                   P+PPL+ LA 
Sbjct: 332 CQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT 391

Query: 227 PPPPVPAPA---PPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAE- 282
           PPP  P PA   PP  A P    +    P      ++  AL     +A  + PP  P + 
Sbjct: 392 PPPQAP-PALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA 450

Query: 283 ----PKGSALGPNPEPHLTFPRSFKVPP--PTPVRTSSIPVQEAQEAPRKEEGATKKAPS 336
               P    + P+  P    P S   PP    P   +S P+  +   P +        P 
Sbjct: 451 PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL 510

Query: 337 RLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPL 396
           +L  PP     P +   P     P  P      AP SP    S S       TPPP  P 
Sbjct: 511 QLAKPPP--QAPPALATPPLQALPSPPASFPGQAPFSP----SASLPMSPLATPPPQAPP 564

Query: 397 PPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPP---SPENT 453
              AP L    PP PPA+P L   ++   P    + +    + AL P P PP   SP +T
Sbjct: 565 VLAAPLL--QVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSST 622

Query: 454 ASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLP-EK 512
            S   +     S       EL  Y  G                A       +GP  P   
Sbjct: 623 LSGPDLAGHS-SSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAF 681

Query: 513 ETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEA 572
                 P    P   P  + G  ++ ETE   S T       P  SP  S  +      A
Sbjct: 682 RGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGA 741

Query: 573 RLSSAAEKEAKPSIGSLP 590
             SS + K+A+  +G LP
Sbjct: 742 GASSRSPKQAR--LGELP 757



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 196/750 (26%), Positives = 257/750 (34%), Gaps = 144/750 (19%)

Query: 146 PAPGPPQDISEPPGGSPLPSPPST-----------APPPPPLL-----LEPPPPPSMAPP 189
           PA   P  ++  P GSP P PP T           A    PL      +     P  AP 
Sbjct: 17  PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76

Query: 190 PPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRL 249
             P         T S+ +    P   PPA      APP     +P P +     +  TR 
Sbjct: 77  AGP---------TRSAGTSSRNPASRPPASGRGERAPPAKNT-SPGPVSSPGRASGTTRP 126

Query: 250 FPPG--GVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP-EPHLTFPRSFK--- 303
            P G  G+     +    G+  EA + S   + A    S  GP P  P     R  +   
Sbjct: 127 GPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTS--GPTPGTPSPAMARRSRAAG 184

Query: 304 ----VPPPTPVRTSSIPVQEAQEAPRK------EEGATKKAPS--RLPLPPSFHIRPASQ 351
               +P P P      P     E PRK      E   T+ +P+  R P       RPAS+
Sbjct: 185 TEVGLPRPAPSARPRPPT----EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 240

Query: 352 VYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL- 410
                A     P     +A  +PR     SQ   +       P + PP     P   PL 
Sbjct: 241 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300

Query: 411 -PPAAPPLPCAQKAAHPPAGFTKTPKSSS---------PALKPKPNPPSPENTASSAPVD 460
             P A P P A   +  P     TP SSS         P   P P+ P    T  S P  
Sbjct: 301 SSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPA- 359

Query: 461 WRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPA 520
              PSQ        A    GS       S  P P ++P +      P+ P    L  L A
Sbjct: 360 -TPPSQ--------ATTSLGSPTLQATHSFLPSPPLSPLA---TPPPQAPPALALPPLQA 407

Query: 521 KDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAA-- 578
             +PP  P  S   +   +   A ++ L    + P  SP P            +S +A  
Sbjct: 408 PPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSP-PVQAPFSPPASPPVSPSATP 466

Query: 579 EKEAKPSIGS----LPPKPRLEGGRICENGADDDKLSKPVA------KNLPPQSTTLLPT 628
             +A PS+ +    +PP P      +  +     +   P+A         PPQ+   L T
Sbjct: 467 PSQAPPSLAAPPLQVPPSPP-ASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT 525

Query: 629 TSLQ-----PKAMLGPA---------IPPKATPEPAIPPKATL----WPATPPKATLGPA 670
             LQ     P +  G A         + P ATP P  PP         P +PP +    A
Sbjct: 526 PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585

Query: 671 TPLKATSGPTTPLKATSGPAIA-STATTLPTTTSQLMAEKDSGP--AGQPEKPASQEVST 727
                T GP T   + SGP +  + A   P   S+  +   SGP  AG     +S   ST
Sbjct: 586 PRRPPTPGPDT---SVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGH----SSSATST 638

Query: 728 PSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMP 787
           P + RG  S  E           +AA PP         P      CH ++ SR  A   P
Sbjct: 639 PEELRGYDSGPEG---------GAAASPP---------PDAELAACHPAAWSRGPA---P 677

Query: 788 TLARGGAAGPGEPVEVKEPPGLPAKPPASA 817
            LA  GA  PG P+     P  PA  P SA
Sbjct: 678 PLAFRGA--PGAPL-----PWPPATGPGSA 700



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 192/785 (24%), Positives = 265/785 (33%), Gaps = 171/785 (21%)

Query: 126 GDLRPGQYGQDLLI--------------PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAP 171
           G  RPG  GQ  L                P     + G  +D S P  G+P P+    + 
Sbjct: 122 GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSR 181

Query: 172 PPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPV 231
                +  P P PS  P PP       P  ++SS S  +  +                  
Sbjct: 182 AAGTEVGLPRPAPSARPRPPTE----GPRKSVSSASEHSTTE------------------ 219

Query: 232 PAPAPPAPASPHTVGTRLFPPG-GVTKWKSDVALNGRQAEATRASP--PRSPAEPKGSAL 288
             P+P A   P   G    P    ++   + ++   R   + R +P  P  P++PK   L
Sbjct: 220 --PSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGL 277

Query: 289 GPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP---SFH 345
                P +T PR    P   P+ +S +        P        +AP  LP  P   S  
Sbjct: 278 QALRPPQVTPPRKDAAPALGPLSSSPLAT------PSPSAALQSQAPPTLPATPHSSSLT 331

Query: 346 IRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPP--------PAPPLP 397
            + A+ + P   P P  P  L+ T P+ P      SQA    G+P         P+PPL 
Sbjct: 332 CQLATPL-PLAPPSPSAPPSLQ-TLPSPP--ATPPSQATTSLGSPTLQATHSFLPSPPLS 387

Query: 398 PPA--PPLPPPAPPLPPA-APPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA 454
           P A  PP  PPA  LPP  APP P     A PP          SP   P P  P      
Sbjct: 388 PLATPPPQAPPALALPPLQAPPSP----PASPPL---------SPLATPSPQAP------ 428

Query: 455 SSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKET 514
                            N LA +L  +       S  P P V        + P  P    
Sbjct: 429 -----------------NALAVHLLQAP-----FSPPPSPPV--------QAPFSPPASP 458

Query: 515 LLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARL 574
            +S  A  TPP     SL    L    + P+    S    P     P +     +L    
Sbjct: 459 PVSPSA--TPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP 516

Query: 575 SSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPK 634
             A    A P + +LP  P    G+               A   P  S  + P  +  P+
Sbjct: 517 PQAPPALATPPLQALPSPPASFPGQ---------------APFSPSASLPMSPLATPPPQ 561

Query: 635 AMLGPAIPPKATPEPAIPPKATLWPAT----------PPKATLGPATPLKATSGP----- 679
           A      P  A P   +PP     P            P  +  GP   L    GP     
Sbjct: 562 AP-----PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 616

Query: 680 TTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAG--QPEKPASQEVSTPSQARGEGSP 737
            +P    SGP +A  +++  +T  +L    DSGP G      P   E++    A     P
Sbjct: 617 RSPSSTLSGPDLAGHSSSATSTPEELRG-YDSGPEGGAAASPPPDAELAACHPAAWSRGP 675

Query: 738 SEATRLPTQGARSS-AAFPPKTSPGGGEVPC-LYKPHCHQSSLSREVAV---VMPTLARG 792
             A  L  +GA  +   +PP T PG  +  C +Y+    +S+     A+     P  + G
Sbjct: 676 --APPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGG 733

Query: 793 -GAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQK 851
             AAG G         G  ++ P  A+   EL    +   VV+      LLLAA + A  
Sbjct: 734 KAAAGAG--------AGASSRSPKQAR-LGELPLGALQASVVQHLLSRTLLLAAAEGAAG 784

Query: 852 GRSVG 856
           G   G
Sbjct: 785 GSGGG 789



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 120/427 (28%), Positives = 149/427 (34%), Gaps = 68/427 (15%)

Query: 92  LAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPP 151
           LA P+PS P        T  S       +  +S+G   P        +P PP  P   PP
Sbjct: 340 LAPPSPSAPPSLQ----TLPSPPATPPSQATTSLGS--PTLQATHSFLPSPPLSPLATPP 393

Query: 152 QDISEPPGGSPLPSPPSTAPPPPPLLLEPPPP-------------PSMAPPPPPVLEALS 198
                     PL +PPS    PP   L  P P             P   PP PPV    S
Sbjct: 394 PQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFS 453

Query: 199 PPHTLSSPSIPTPPDFIPP---APPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGV 255
           PP +       TPP   PP   APPL    PP PP   P  P+   P      L  P   
Sbjct: 454 PPASPPVSPSATPPSQAPPSLAAPPLQ--VPPSPPASPPMSPSATPPPQAPPPLAAP--- 508

Query: 256 TKWKSDVALNGRQAEATRASPP-RSPAEPKGSALGPNP-EPHLTFPRS-FKVPPPTPVRT 312
                 +A    QA    A+PP ++   P  S  G  P  P  + P S    PPP     
Sbjct: 509 ---PLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV 565

Query: 313 SSIPVQEAQEAPRKEEGATKKAPSRLPLPP----------SFHIRPASQVYPDRAPE--- 359
            + P+   Q  P      T +AP R P P           +  + P     P R+P    
Sbjct: 566 LAAPL--LQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTL 623

Query: 360 --PDCPG-ELKATAPASPRLGQSQSQADERAGTPPPAPPLPP--PAPPLPPPAPPLP-PA 413
             PD  G    AT+      G         A +PPP   L    PA     PAPPL    
Sbjct: 624 SGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRG 683

Query: 414 APPLPCAQKAAHPPAGF--------TKTPKSSSP---ALKPKPNPPSPENTASS---APV 459
           AP  P     A  P           T+ P+S++P   AL P P+P +    A++   A  
Sbjct: 684 APGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGA 743

Query: 460 DWRDPSQ 466
             R P Q
Sbjct: 744 SSRSPKQ 750



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 210/883 (23%), Positives = 281/883 (31%), Gaps = 170/883 (19%)

Query: 376  LGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPL--------------PCAQ 421
            +   + +A   A    PA   P    P PP +P  PP   P               P A+
Sbjct: 1    MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60

Query: 422  KAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGS 481
            +A     G    P+S+  A   +    S  N AS  P   R   +    +N     +   
Sbjct: 61   RAG--GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRG-ERAPPAKNTSPGPVSSP 117

Query: 482  RREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTP----------------- 524
             R     + RPGP        G+KG R+  +ET+    A + P                 
Sbjct: 118  GRASG--TTRPGPL-------GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT 168

Query: 525  PGVPEKSLG-GSSLTETEAAPSLTLPSV-DYIPQDSPTPSVRQIRNELEARLSSAAEKEA 582
            PG P  ++   S    TE       PS     P + P  SV           S AA +  
Sbjct: 169  PGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR-- 226

Query: 583  KPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPK-----AML 637
            +PS G    +P     R   + A    LS P       + T   P    QPK     A+ 
Sbjct: 227  RPSAGGGLQRP---ASRSLSSSA--TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALR 281

Query: 638  GPAI-PPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTAT 696
             P + PP+    PA+ P      ++ P AT  P+  L++ + PT P    S       AT
Sbjct: 282  PPQVTPPRKDAAPALGPL-----SSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLAT 336

Query: 697  TLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGE-GSPS-EATR--LPTQGARSSA 752
             LP     L     S P      P S   + PSQA    GSP+ +AT   LP+      A
Sbjct: 337  PLP-----LAPPSPSAPPSLQTLP-SPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA 390

Query: 753  AFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAA---------GPGEPVEV 803
              PP+  P     P    P    S     +A   P      A           P  PV+ 
Sbjct: 391  TPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA 450

Query: 804  K-EPPGLP-----AKPPASAQPT--DELLRHPVTGEVVERGSPMALLLAARQRAQKGRSV 855
               PP  P     A PP+ A P+     L+ P +       SP A              +
Sbjct: 451  PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL 510

Query: 856  GAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNK 915
              A      P +L     QA  S  + F  Q         P  P  +   SPL T     
Sbjct: 511  QLAKPPPQAPPALATPPLQALPSPPASFPGQ--------APFSPSASLPMSPLAT----- 557

Query: 916  WGPRLGRDAEGTELSRRHNWTKPEPQAPVAWE----RVAPSNLPQGHPLPKSFSSPPSPS 971
                                  P PQAP        +V PS  P   P  ++   PP+P 
Sbjct: 558  ----------------------PPPQAPPVLAAPLLQVPPS--PPASPTLQAPRRPPTPG 593

Query: 972  NKREEEEEEFNFEVIP-PPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQL---PNAG 1027
                         + P PPP  S  P          G  SS   +   +LR     P  G
Sbjct: 594  PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSS-ATSTPEELRGYDSGPEGG 652

Query: 1028 PGAPP----------ALGFSRFPA-GARYAGAGGL----ERFSGGGRSLIKKRLYVGE-- 1070
              A P             +SR PA    + GA G        +G G +     +Y  E  
Sbjct: 653  AAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGP 712

Query: 1071 ----PHRG---PGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHA------ 1117
                P  G   PG   G +G   ++    G     P+  R+   G  P G L A      
Sbjct: 713  ESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARL---GELPLGALQASVVQHL 769

Query: 1118 -PRLSLEGAARGAAEAKHKAPGSADYGFAPAAGRSPYTTTRYG 1159
              R  L  AA GAA      PG A+ G      R+  +    G
Sbjct: 770  LSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELG 812


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score =  101 bits (251), Expect = 5e-21
 Identities = 149/589 (25%), Positives = 197/589 (33%), Gaps = 106/589 (17%)

Query: 149 GPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSI 208
           G P   +     +P    P  AP PPP     P       P PP            SP  
Sbjct: 65  GSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPP------------SPRR 112

Query: 209 PTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQ 268
           P  P    PAPP A L PPP        P PA+          P G  K     AL    
Sbjct: 113 PLVP--AGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAAL---- 166

Query: 269 AEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEE 328
             A RA P   P        GP P P    P     P        S  +  +  A     
Sbjct: 167 --AARAGPGPGPGP------GPGPGPGPGKPAG---PGAAQTLNGSAALLNSHHAAAPAV 215

Query: 329 GATKKAPSR-LPLP----PSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQA 383
                 P+  LPLP    P   I+    V     P P  P    A APA+P         
Sbjct: 216 SLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAP--------- 266

Query: 384 DERAGTPPPAPPLP-----PPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSS 438
              A  PPP PP P     PP  P  PP     PA PP   AQ      A     P +  
Sbjct: 267 ---AAAPPPPPPAPATLARPPGHPAGPPT--AAPAVPPPAAAQNGGSAGAAPAPAPAAGG 321

Query: 439 PALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAP 498
           PA       P     A +  V    P ++ +     A  L  S       S   GPT+  
Sbjct: 322 PAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQ- 380

Query: 499 QSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGG--SSLTETEAA----------PSL 546
                     LP     +  PA  TP G+P+ + G    SL+ T  A          P++
Sbjct: 381 --------GALP-SPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTV 431

Query: 547 TLPSVDYIPQDSPT--------PSVRQIRNE--------LEARLSSAAEKEAKPSIGSLP 590
             P +   PQ +PT        P +  +R+E         +A     A+  A+P   ++ 
Sbjct: 432 LAPRLPQPPQ-NPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQAHAQPQT-TMA 489

Query: 591 PKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE-- 648
           P+P           A   ++S   A   P  +  + PTT ++  +     + P AT +  
Sbjct: 490 PRP------ATPTSAPPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPSATLQRS 543

Query: 649 PAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATT 697
           P + P+  L  A    A+LG AT ++      TP +   G    S+A T
Sbjct: 544 PGVQPQLVLGGAA-QTASLGTATAVQT----GTPQRTVPGATTTSSAAT 587



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 173/723 (23%), Positives = 249/723 (34%), Gaps = 134/723 (18%)

Query: 140 PPPPPGPAPGPPQDISEPPGGSP--------LPSPPSTAP--------PPPPLLLEPPPP 183
           P P PGP PGP       PG +         L S  + AP        P   L L  P  
Sbjct: 174 PGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAA 233

Query: 184 PSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPA----- 238
           P      PP + A +PP    +P+ P+PP    PA P A  APPPPP   PAP       
Sbjct: 234 PGTVIQTPPFVGAAAPP----APAAPSPPAAPAPAAPAA--APPPPP---PAPATLARPP 284

Query: 239 --PASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHL 296
             PA P T    + PP          A NG  A A  A     PA   G   G + +P  
Sbjct: 285 GHPAGPPTAAPAVPPPA--------AAQNGGSAGAAPA-----PAPAAGGPAGVSGQPG- 330

Query: 297 TFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDR 356
             P +    P   V+  S P +  Q AP                       PA+Q     
Sbjct: 331 --PGAAAAAPAPGVKAES-PKRVVQAAP-----------------------PAAQTLAAS 364

Query: 357 APEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPP 416
            P         A+  AS  +G +        G  P    +PPPAP  P   P     A  
Sbjct: 365 GP---------ASTAASMVIGPTMQ------GALPSPAAVPPPAPGTPTGLPKGAAGAVT 409

Query: 417 LPCAQKAAHPPAGF--TKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNEL 474
              ++      +G   T TP   +P L P+P P +P N       +++ P  M  +R+E 
Sbjct: 410 QSLSRTPTATTSGIRATLTPTVLAPRL-PQP-PQNPTNIQ-----NFQLPPGMVLVRSEN 462

Query: 475 AAYLCGSRR---EDRFLSH-RPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTP----PG 526
              L   ++   + +  +H +P  T+AP+       P +     + ++ A  TP      
Sbjct: 463 GQLLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPV----QISTVQAPGTPIIARQV 518

Query: 527 VPEKSLGGSSLTETEAAPSLTLP-SVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKP- 584
            P   +   S  +T   PS TL  S    PQ     + +         + +   +   P 
Sbjct: 519 TPTTIIKQVSQAQTTVQPSATLQRSPGVQPQLVLGGAAQTASLGTATAVQTGTPQRTVPG 578

Query: 585 -SIGSLPPKPRLEGGRICENG-------ADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAM 636
            +  S      +E  + C+N        A   K S   A N+      LL          
Sbjct: 579 ATTTSSAATETMENVKKCKNFLSTLIKLASSGKQSTETAANVKELVQNLLDGKIEAEDFT 638

Query: 637 LGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTAT 696
                   ++P+P + P   L  + P    L P +          P   TS    A TA 
Sbjct: 639 SRLYRELNSSPQPYLVP--FLKRSLPALRQLTPDSAAFIQQSQQQPPPPTSQATTALTAV 696

Query: 697 TLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAF-- 754
            L +++ Q  A K +       +P    ++ P+Q  G G   + T L  Q      A   
Sbjct: 697 VL-SSSVQRTAGKTAATVTSALQPPVLSLTQPTQV-GVGKQGQPTPLVIQQPPKPGALIR 754

Query: 755 PPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPP 814
           PP+ +     +  L +PH            +M T  +     P +PV V +P  LP    
Sbjct: 755 PPQVTLTQTPMVALRQPHNR----------IMLTTPQQIQLNPLQPVPVVKPAVLPGTKA 804

Query: 815 ASA 817
            SA
Sbjct: 805 LSA 807



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 99/356 (27%), Positives = 126/356 (35%), Gaps = 67/356 (18%)

Query: 110 GTSSLVNGNLRLYSSVGDLRPG----QYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPS 165
           G +  +NG+  L +S     P       G   L+P P P  APG    + + P      +
Sbjct: 193 GAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPA-APGT---VIQTPPFVGAAA 248

Query: 166 PPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLA 225
           PP+ A P PP    P  P +  PPPPP       P TL+      PP   P  PP A  A
Sbjct: 249 PPAPAAPSPPAAPAPAAPAAAPPPPPPA------PATLA-----RPPGH-PAGPPTAAPA 296

Query: 226 PPPP------------PVPAPAPPAPA----SPHTVGTRLFPPGGV--TKWKSDVALNGR 267
            PPP            P PAPA   PA     P        P  GV     K  V     
Sbjct: 297 VPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPP 356

Query: 268 QAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKE 327
            A+   AS P S A      +GP  +  L  P +  VPPP P   + +P   A       
Sbjct: 357 AAQTLAASGPASTA--ASMVIGPTMQGALPSPAA--VPPPAPGTPTGLPKGAA------- 405

Query: 328 EGATKKAPSRLPLPPSFHIRP--ASQVYPDRAPEPD-----------CPGELKATAPASP 374
            GA  ++ SR P   +  IR      V   R P+P             PG +   +    
Sbjct: 406 -GAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVRSENGQ 464

Query: 375 RL---GQSQSQADERAGTPPPAPPLPPPAPPL-PPPAPPLPPAAPPLPCAQKAAHP 426
            L    Q+ +Q   +A   P     P PA P   PP       AP  P   +   P
Sbjct: 465 LLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPVQISTVQAPGTPIIARQVTP 520



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 49/201 (24%), Positives = 68/201 (33%), Gaps = 33/201 (16%)

Query: 638 GPAIPPKA-TPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTAT 696
           GP  P +   P    PP A L P  PP+ + G   P+ A +         +GP  A    
Sbjct: 106 GPPSPRRPLVPAGPAPPAAKLRP--PPEGSAGSCAPVPAAAA------VAAGPEPAPAGP 157

Query: 697 TLPTTTSQLMAEKDSGPA-----------GQPEKPASQEVSTPSQA--RGEGSPSEATRL 743
             P   + L A    GP            G+P  P + +    S A      + + A  L
Sbjct: 158 AKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSL 217

Query: 744 PTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAG------- 796
              G  +    P   +PG      +  P    ++     A   P  A   AA        
Sbjct: 218 VNNGPAALLPLPKPAAPG----TVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPP 273

Query: 797 PGEPVEVKEPPGLPAKPPASA 817
           P  P  +  PPG PA PP +A
Sbjct: 274 PPAPATLARPPGHPAGPPTAA 294



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 83/350 (23%), Positives = 107/350 (30%), Gaps = 50/350 (14%)

Query: 638 GPAIP----PKATPEPAIPPKATLWPATPPKATLGPATPLK--ATSGPTTPLKATSGPAI 691
           GPA P    P A PEP  PP     P        GP +P +    +GP  P      P  
Sbjct: 74  GPAAPAEGAPGAAPEP--PPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPE 131

Query: 692 ASTATTLPTTTSQLMAE-KDSGPAGQPEKPASQEVST------------PSQARGEGSPS 738
            S  +  P   +  +A   +  PAG P KPA                  P    G G P+
Sbjct: 132 GSAGSCAPVPAAAAVAAGPEPAPAG-PAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPA 190

Query: 739 EATRLPTQGARSS------AAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARG 792
                 T    ++      AA P  +    G    L  P             V+ T    
Sbjct: 191 GPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPK------PAAPGTVIQTPPFV 244

Query: 793 GAAGPGEPVEVKEP----PGLPAKPPASAQPTDELLRHPVTGEVVERGSPMAL-LLAARQ 847
           GAA P  P     P    P  PA  P    P    L  P        G P A   +    
Sbjct: 245 GAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPA---GPPTAAPAVPPPA 301

Query: 848 RAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSP 907
            AQ G S GAA   +   G     S Q    + +   + G      V  + PK   + +P
Sbjct: 302 AAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPG------VKAESPKRVVQAAP 355

Query: 908 LTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQG 957
              +     GP     A    +        P P A        P+ LP+G
Sbjct: 356 PAAQTLAASGP--ASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKG 403



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 56/229 (24%), Positives = 77/229 (33%), Gaps = 47/229 (20%)

Query: 938  PEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPE 997
            P+P AP    +  P       P P + S P +P+               P  P  +  P 
Sbjct: 229  PKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPA---------------PAAPAAAPPPP 273

Query: 998  PPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERF--- 1054
            PPAPA   L R    P          P A P  PP       PA A+  G+ G       
Sbjct: 274  PPAPAT--LARPPGHPAGP-------PTAAPAVPP-------PAAAQNGGSAGAAPAPAP 317

Query: 1055 SGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGG 1114
            + GG + +      G+P  G        G    SP     Q   P  + + ++G A    
Sbjct: 318  AAGGPAGVS-----GQPGPGAAAAAPAPGVKAESPKRV-VQAAPPAAQTLAASGPASTAA 371

Query: 1115 LHAPRLSLEGAARGAAEAKHKAPGSADYGFAPAAG-------RSPYTTT 1156
                  +++GA    A     APG+       AAG       R+P  TT
Sbjct: 372  SMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATT 420



 Score = 31.6 bits (70), Expect = 4.7
 Identities = 55/237 (23%), Positives = 66/237 (27%), Gaps = 25/237 (10%)

Query: 950  APSNLPQGHPLPKSFS----SPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQY 1005
            AP   P G   P         PPSP               + PPPE S     P PA   
Sbjct: 86   APEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAA 145

Query: 1006 LGRQSSP----PRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSL 1061
            +     P    P            AGPG  P  G    P   + AG G  +  +G    L
Sbjct: 146  VAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALL 205

Query: 1062 IKKRL---YVGEPHRGPG----LPH-GGTGRSLSSPNCFG---------PQPGGPEMRRV 1104
                     V   + GP     LP     G  + +P   G         P P        
Sbjct: 206  NSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAA 265

Query: 1105 NSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSADYGFAPAAGRSPYTTTRYGSP 1161
             +A   PP    A      G   G   A    P  A      +AG +P      G P
Sbjct: 266  PAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGP 322


>gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]
          Length = 1003

 Score =  100 bits (250), Expect = 6e-21
 Identities = 238/967 (24%), Positives = 314/967 (32%), Gaps = 185/967 (19%)

Query: 139  IPPPPPGPAPG----PPQDISEPPGGSPLPSPPS------TAPPP----PPLLLEPPP-- 182
            + P PP   P     P   ++  PG  P P PPS      T   P    PP L +P P  
Sbjct: 138  VSPGPPSARPPCRVPPTTPLNGGPGSLP-PEPPSVSQAFPTLAGPGGLFPPRLADPVPSG 196

Query: 183  ------------PPSMAPPPPPVLEALSPPHTLSSP--SIPTPPDF-IPPAPPLAFLAPP 227
                         PS APPPPP +   +P +   +   S   P D   PPAP  +   P 
Sbjct: 197  GSSSPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPHASSSPPS 256

Query: 228  PPPV--------PAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRS 279
             PP+        P P PP+   P   G    PP         + L       T   P   
Sbjct: 257  DPPLFHCSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLPLVLGPLGGAPTVEGPGAP 316

Query: 280  P--AEPKGSALGPNPEPHLTFPRSFKVPPP---TPVRTSSIPVQEAQEAPRKEEGATKKA 334
            P  A    SA      P L  P + +   P    P  + S  ++ +Q  PR+     +  
Sbjct: 317  PFLASSLLSAAAKAQHPPLPPPSTLQGRRPRAQAPSASHSSSLRPSQRRPRRPPTVFRLL 376

Query: 335  PSRLPLPP--SFHIRPASQVYPDRAPEPDCP------GELKATAPASPRLGQSQSQADER 386
              R P  P  S    PA    P   PEP  P        L    P       S +     
Sbjct: 377  EGRGPQTPRRSRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSD 436

Query: 387  AGTPPPAPPLPPPAPPLP--PPAPPLP----------PAAPPLPCAQKAAHPPAGFTKTP 434
            A  PPP P L   +PP P  P  P LP          P AP  P A KA   P+   ++P
Sbjct: 437  AHLPPP-PTLSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSP 495

Query: 435  KSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGP 494
             S    +   P  P P   A      +  P Q   L       + G+      L   P  
Sbjct: 496  -SEGLGMGAGPACPLPP-LAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPS 553

Query: 495  TVAPQSKEG--KKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVD 552
             +   S  G    G   P  E LL  P    PP  P +  G S L  +   P    P  D
Sbjct: 554  PLLNHSLFGVLTGGGGQPPPEPLLPPPGGPGPPLAPGEPEGPSLLVASLLPP----PPSD 609

Query: 553  YIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSK 612
             +P  S  PS     N L + L         P +   P     EG      G   +  S 
Sbjct: 610  LLPPPSAPPS-----NLLASFL---------PLLALGPTAGDGEGSAEGAGGPSGEPFS- 654

Query: 613  PVAKNLPPQSTTLLPTTSLQPK--AMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPA 670
                 L   S  L P  S  P   A+    +     P    PP+  +  A  P    GP 
Sbjct: 655  ----GLGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAPQP----GPP 706

Query: 671  TPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQ 730
            T                  +  +TATT P  +S   A  +SG   Q   P          
Sbjct: 707  T------------------SSVTTATTDPGASSLGKAPSNSGRPPQLLSPLLGASLLGDL 748

Query: 731  ARGEGSPSE-ATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTL 789
            +    SP    + L   G   S     +  PGGG  P L       S  S  +A ++ +L
Sbjct: 749  SSLTSSPGALPSLLQPPGPLLSGQLGLQLLPGGGAPPPL-------SEASSPLACLLQSL 801

Query: 790  ARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGS---PMALLLAAR 846
                      P E  E P LP + PASA    E  R P++      GS   P+  LL  R
Sbjct: 802  Q--------IPPEQPEAPCLPPESPASAL-EPEPARPPLSALAPPHGSPDPPVPELLTGR 852

Query: 847  QRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDS 906
               ++GR  G         G LR  + +A  +      S+  P    +            
Sbjct: 853  GSGKRGRRGG---------GGLRGINGEARPARGRKPGSRREPGRLAL------------ 891

Query: 907  PLTTEIPNKWGPRLGRDAEGTELSRR-HNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFS 965
                    KWG R G + +     RR H+W   +    +A     P + P   P  +   
Sbjct: 892  --------KWGTRGGFNGQMERSPRRTHHW---QHNGELAEGGAEPKDPPPPGPHSEDLK 940

Query: 966  SPPSPSNK-REEEEEEFNFEVIPPPPEFSN--------DPEPPAPALQYLGRQSSPPRNN 1016
             PP    K R     ++N      P   SN        +P P A A   L  ++ P R  
Sbjct: 941  VPPGVVRKSRRGRRRKYN------PTRNSNSSRQDITLEPSPTARAAVPLPPRARPGRPA 994

Query: 1017 YSDLRQL 1023
             +  R+L
Sbjct: 995  KNKRRKL 1001



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 179/688 (26%), Positives = 232/688 (33%), Gaps = 158/688 (22%)

Query: 82  LPLNAQE-NHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIP 140
           + LNA   N G A+ +  VP D         SS    +  L+          +  D L P
Sbjct: 220 ISLNAPSYNWGAALRSSLVPSDLGSPPAPHASSSPPSDPPLF----------HCSDALTP 269

Query: 141 PP---------PPGPAPGPPQD--------ISEPPGGSPLPSPPSTAPPPPPLLLE---- 179
           PP          PGPA  PP          +  P GG+P    P   P     LL     
Sbjct: 270 PPLPPSNNLPAHPGPASQPPVSSATMHLPLVLGPLGGAPTVEGPGAPPFLASSLLSAAAK 329

Query: 180 ----PPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFL----------- 224
               P PPPS      P  +A S  H+ S      P    P  PP  F            
Sbjct: 330 AQHPPLPPPSTLQGRRPRAQAPSASHSSSL----RPSQRRPRRPPTVFRLLEGRGPQTPR 385

Query: 225 -------APPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPP 277
                  AP P P   P P  P  P  +     P  G +   SD + N   ++A    PP
Sbjct: 386 RSRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPTPGPSH--SDGSFNLLGSDAHLPPPP 443

Query: 278 R----SPAEPKGSALGPNPEPHLTFPRSFKVP-PPTPVRTSSIPVQEAQEAPRKEEGATK 332
                SP +P+   + P+  P  T      VP  P P   S  PV  +       EG   
Sbjct: 444 TLSSGSPPQPR-HPIQPSL-PGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSEGLGM 501

Query: 333 KAPSRLPLPPSFHIRPASQVYPDRAPEPDC-------PGELKATA--------PASPRLG 377
            A    PLPP        + +P  +PE          PG L A          P SP L 
Sbjct: 502 GAGPACPLPPL----AGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPLLN 557

Query: 378 QSQSQADERAGTPPPAPP-LPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKS 436
            S        G  PP  P LPPP  P PP AP   P  P L  A     PP+        
Sbjct: 558 HSLFGVLTGGGGQPPPEPLLPPPGGPGPPLAPG-EPEGPSLLVASLLPPPPSD------- 609

Query: 437 SSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTV 496
               L P P+ P     AS  P+    P+  +    E +A   G            GP+ 
Sbjct: 610 ----LLPPPSAPPSNLLASFLPLLALGPTAGD---GEGSAEGAG------------GPSG 650

Query: 497 APQSKEGKKG----PRLPEKETLLSL----------PAKDTPP-----GVPEKSLGGSSL 537
            P S  G       P L    TL++L          P   TPP       P+     SS+
Sbjct: 651 EPFSGLGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAPQPGPPTSSV 710

Query: 538 TETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARL-----SSAAEKEAKPSIGSLPPK 592
           T     P  +  S+   P +S  P  + +   L A L     S  +   A PS+   PP 
Sbjct: 711 TTATTDPGAS--SLGKAPSNSGRPP-QLLSPLLGASLLGDLSSLTSSPGALPSL-LQPPG 766

Query: 593 PRLEGG---RICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKA---- 645
           P L G    ++   G     LS+  +         LL +  + P+    P +PP++    
Sbjct: 767 PLLSGQLGLQLLPGGGAPPPLSEASS-----PLACLLQSLQIPPEQPEAPCLPPESPASA 821

Query: 646 -TPEPAIPPKATLWPATPPKATLGPATP 672
             PEPA PP + L    PP  +  P  P
Sbjct: 822 LEPEPARPPLSAL---APPHGSPDPPVP 846



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 224/944 (23%), Positives = 301/944 (31%), Gaps = 172/944 (18%)

Query: 277  PRSPAEPKGSALGPNPEPHLT---FPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKK 333
            P +P  P G+ +GP  E  +T     R   V   T  R+       +       EGA+ +
Sbjct: 78   PLAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPG----EGASPQ 133

Query: 334  APSRL-PLPPSFHIRPASQVYPDRAPEPDCPGELKATAPA---------------SPRL- 376
                + P PPS   RP  +V P   P    PG L    P+                PRL 
Sbjct: 134  MFHTVSPGPPS--ARPPCRV-PPTTPLNGGPGSLPPEPPSVSQAFPTLAGPGGLFPPRLA 190

Query: 377  ------GQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGF 430
                  G S  +   R   P PAPP PPPA  L  P+     A            PPA  
Sbjct: 191  DPVPSGGSSSPRFLPRGNAPSPAPP-PPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPH 249

Query: 431  TKTPKSSSP-------ALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRR 483
              +   S P       AL P P PPS    A   P   + P     +   L         
Sbjct: 250  ASSSPPSDPPLFHCSDALTPPPLPPSNNLPAHPGPAS-QPPVSSATMHLPLVL------- 301

Query: 484  EDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGG--------- 534
                     GP     + EG   P       L +      PP  P  +L G         
Sbjct: 302  ---------GPLGGAPTVEGPGAPPFLASSLLSAAAKAQHPPLPPPSTLQGRRPRAQAPS 352

Query: 535  ----SSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSS-----AAEKEAKPS 585
                SSL  ++  P    P+V  + +     + R+ R    A +          +   PS
Sbjct: 353  ASHSSSLRPSQRRPRRP-PTVFRLLEGRGPQTPRRSRPRAPAPVPQPFSLPEPSQPILPS 411

Query: 586  IGSL----PPKPRLEGGRICENGADDDKLSKP-VAKNLPPQ-----STTLLPTTSLQPKA 635
            + SL     P P    G     G+D      P ++   PPQ       +L  TTS    +
Sbjct: 412  VLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGSLSS 471

Query: 636  MLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTA 695
            + G   PP A+  P +P      P+       GPA PL   +G       +    +A + 
Sbjct: 472  VPGAPAPPAASKAPVVPSPVLQSPSEGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSG 531

Query: 696  TTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFP 755
               P     L      G    P  P            G G P     LP  G        
Sbjct: 532  AGFPGMLGALPLPLSLGQ--PPPSPLLNHSLFGVLTGGGGQPPPEPLLPPPGGPG----- 584

Query: 756  PKTSPGGGEVPCLY--------------KPHCHQSSLSREVAVVMPTLARGGAAGPGE-- 799
            P  +PG  E P L                P    S+L   +A  +P LA G  AG GE  
Sbjct: 585  PPLAPGEPEGPSLLVASLLPPPPSDLLPPPSAPPSNL---LASFLPLLALGPTAGDGEGS 641

Query: 800  PVEVKEPPGLPAK----------PPASAQPTDELLRHPVTGEVVERGS---PMALLLAAR 846
                  P G P            PP SA PT   L   +    ++  S   P   +L+A 
Sbjct: 642  AEGAGGPSGEPFSGLGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAP 701

Query: 847  QRAQKGRSVGAAL---GRSSLPGSLRDHSHQAEASSDSIFHS-QGTPNSFTVVP-KLPKE 901
            Q      SV  A    G SSL  +  +     +  S  +  S  G  +S T  P  LP  
Sbjct: 702  QPGPPTSSVTTATTDPGASSLGKAPSNSGRPPQLLSPLLGASLLGDLSSLTSSPGALPSL 761

Query: 902  AEKDSPLTT-EIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960
             +   PL + ++  +  P  G     +E S         P A +      P   P+   L
Sbjct: 762  LQPPGPLLSGQLGLQLLPGGGAPPPLSEAS--------SPLACLLQSLQIPPEQPEAPCL 813

Query: 961  PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020
            P     P SP++  E E        + PP      P+PP P L          R     L
Sbjct: 814  P-----PESPASALEPEPARPPLSALAPP---HGSPDPPVPELLTGRGSGKRGRRGGGGL 865

Query: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPH- 1079
            R +      A PA G  R P   R  G   L+  + GG        + G+  R P   H 
Sbjct: 866  RGINGE---ARPARG--RKPGSRREPGRLALKWGTRGG--------FNGQMERSPRRTHH 912

Query: 1080 ----GGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPR 1119
                G      + P    P P GP    +    + PPG +   R
Sbjct: 913  WQHNGELAEGGAEPK--DPPPPGPHSEDL----KVPPGVVRKSR 950


>gi|221139926 NHS-like 1 [Homo sapiens]
          Length = 1606

 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 137/516 (26%), Positives = 204/516 (39%), Gaps = 81/516 (15%)

Query: 62   SESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRL 121
            S+S T T      + P+  FL   +  N G   P P VP+      +  + S+ + +  L
Sbjct: 854  SQSNTPTA-----LTPVPVFLKSVSPAN-GKGKPKPKVPE--RKSSLISSVSISSSSTSL 905

Query: 122  YSSVGDLRPGQYGQ-DLLI---PPPPPGPAPGPPQDISEPPGGSPL--PSPPST-----A 170
             SS      G   + D  +   P PPP P P PP     P   SP   P PP T     +
Sbjct: 906  SSSTSTEGSGTMKKLDPAVGSPPAPPPPPVPSPPFPC--PADRSPFLPPPPPVTDCSQGS 963

Query: 171  PPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPP 230
            P P   +  PPPP ++ P   P    LSPP    SP +P  P  +P  PPL      P  
Sbjct: 964  PLPHSPVFPPPPPEALIPFCSPPDWCLSPPRPALSPILPDSPVSLPLPPPLL-----PSS 1018

Query: 231  VPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGP 290
             P PAPP         TR  PP            N  Q E++R S  R P+  + ++  P
Sbjct: 1019 EPPPAPPLDPK-FMKDTR--PP----------FTNSGQPESSRGS-LRPPSTKEETSRPP 1064

Query: 291  NPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350
             P   L    + ++    PVR +S     A+ A   E  A ++   R P+ P +H++P++
Sbjct: 1065 MP---LITTEALQMVQLRPVRKNS----GAEAAQLSERTAQEQ---RTPVAPQYHLKPSA 1114

Query: 351  QVYP-DRAPEPDCPGELKATAPASPRLGQSQSQAD-----ERAGTPPPAPPLPPPAPPLP 404
             +   +   E +   +  +   + P   +S SQ D     ER G    +P  P       
Sbjct: 1115 FLKSRNSTNEMESESQPASVTSSLPTPAKSSSQGDHGSAAERGGPVSRSPGAPSAGEAEA 1174

Query: 405  PPAP---PLPPAAP---PLPCAQK------AAHPPAGFTKTP-KSSSPALKPKPNP---- 447
             P+P   PLP ++P   P P ++K         P   F   P ++ S AL+  P+P    
Sbjct: 1175 RPSPSTTPLPDSSPSRKPPPISKKPKLFLVVPPPQKDFAVEPAENVSEALRAVPSPTTGE 1234

Query: 448  -------PSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQS 500
                    + E++A+ A      P     L    A  +  SR E      +P  + AP+ 
Sbjct: 1235 EGSVHSREAKESSAAQAGSHATHPG-TSVLEGGAAGSMSPSRVEANVPMVQPDVSPAPKQ 1293

Query: 501  KEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSS 536
            +E  +       +    L  +D   GVPE +  GSS
Sbjct: 1294 EEPAENSADTGGDGESCLSQQDGAAGVPETNAAGSS 1329



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 122/463 (26%), Positives = 155/463 (33%), Gaps = 112/463 (24%)

Query: 126  GDLRPGQYGQDLLIPPPPPG---PAPGPPQD----ISEPPGGSPLPSPPSTAPPPPPLLL 178
            G +R  Q G    +P  P G   P    P+     IS   G S   + P+   P P  L 
Sbjct: 811  GPVRHVQEGSRATMPQVPGGSVKPKIMSPEKSHRVISPSSGYSSQSNTPTALTPVPVFLK 870

Query: 179  EPPPPPSMAPPPPPVLE---------ALSPPHTLSSPSIPTPP-------DFIPPAPPLA 222
               P      P P V E         ++S   T  S S  T         D    +PP  
Sbjct: 871  SVSPANGKGKPKPKVPERKSSLISSVSISSSSTSLSSSTSTEGSGTMKKLDPAVGSPP-- 928

Query: 223  FLAPPPPPVPAPAPPAPA--SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASP-PRS 279
              APPPPPVP+P  P PA  SP      L PP  VT             + ++ SP P S
Sbjct: 929  --APPPPPVPSPPFPCPADRSPF-----LPPPPPVT-------------DCSQGSPLPHS 968

Query: 280  PAEPKGSALGPNPEPHLTF--PRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSR 337
            P  P      P PE  + F  P  + + PP P  +  +P                 +P  
Sbjct: 969  PVFPP-----PPPEALIPFCSPPDWCLSPPRPALSPILP----------------DSPVS 1007

Query: 338  LPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLP 397
            LPLPP   + P+S+  P  AP  D P  +K T P     GQ +S                
Sbjct: 1008 LPLPPP--LLPSSE--PPPAPPLD-PKFMKDTRPPFTNSGQPESSRGS------------ 1050

Query: 398  PPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSA 457
                 L PP+     + PP+P     A          K+S           + E     A
Sbjct: 1051 -----LRPPSTKEETSRPPMPLITTEALQMVQLRPVRKNSGAEAAQLSERTAQEQRTPVA 1105

Query: 458  PVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLS 517
            P     PS   K RN        S+      S    PT A  S +G  G           
Sbjct: 1106 PQYHLKPSAFLKSRNSTNEMESESQPASVTSSL---PTPAKSSSQGDHGSAAER------ 1156

Query: 518  LPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPT 560
                    G   +S G  S  E EA PS   PS   +P  SP+
Sbjct: 1157 -------GGPVSRSPGAPSAGEAEARPS---PSTTPLPDSSPS 1189



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 198/910 (21%), Positives = 287/910 (31%), Gaps = 242/910 (26%)

Query: 323  APRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGE----LKATAPASPRLGQ 378
            +P     +    P+ L   P F ++  S       P+P  P      + + + +S     
Sbjct: 847  SPSSGYSSQSNTPTALTPVPVF-LKSVSPANGKGKPKPKVPERKSSLISSVSISSSSTSL 905

Query: 379  SQSQADERAGTPPPAPPL--PPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKS 436
            S S + E +GT     P    PPAPP PPP P     +PP PC              P  
Sbjct: 906  SSSTSTEGSGTMKKLDPAVGSPPAPP-PPPVP-----SPPFPC--------------PAD 945

Query: 437  SSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTV 496
             SP L P   PP   + +  +P                             L H P   V
Sbjct: 946  RSPFLPP---PPPVTDCSQGSP-----------------------------LPHSP---V 970

Query: 497  APQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQ 556
             P        P     +  LS P     P +P+  +            SL LP    +P 
Sbjct: 971  FPPPPPEALIPFCSPPDWCLSPPRPALSPILPDSPV------------SLPLPP-PLLPS 1017

Query: 557  DSPTPSVR---QIRNELEARLSSAAEKEAKPSIGSL-PPKPRLEGGRICENGADDDKLSK 612
              P P+     +   +     +++ + E+  S GSL PP  + E  R             
Sbjct: 1018 SEPPPAPPLDPKFMKDTRPPFTNSGQPES--SRGSLRPPSTKEETSR------------- 1062

Query: 613  PVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATP--PKATLGPA 670
                  PP    L+ T +LQ    L P           +  +      TP  P+  L P+
Sbjct: 1063 ------PPMP--LITTEALQ-MVQLRPVRKNSGAEAAQLSERTAQEQRTPVAPQYHLKPS 1113

Query: 671  TPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQ 730
              LK+ +  T  +++ S PA  +++   P  +S   ++ D G A +   P S+    PS 
Sbjct: 1114 AFLKSRNS-TNEMESESQPASVTSSLPTPAKSS---SQGDHGSAAERGGPVSRSPGAPSA 1169

Query: 731  ARGEGSPSEAT---------RLPTQGARSSAAF----PPK------------------TS 759
               E  PS +T         R P   ++    F    PP+                   S
Sbjct: 1170 GEAEARPSPSTTPLPDSSPSRKPPPISKKPKLFLVVPPPQKDFAVEPAENVSEALRAVPS 1229

Query: 760  PGGGEVPCLYKPHCHQSSLSREVAVVM---PTLARGGAAGPGEP--VEVKEPPGLPAKPP 814
            P  GE   ++     +SS ++  +       ++  GGAAG   P  VE   P   P   P
Sbjct: 1230 PTTGEEGSVHSREAKESSAAQAGSHATHPGTSVLEGGAAGSMSPSRVEANVPMVQPDVSP 1289

Query: 815  ASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQ 874
            A  Q        P        G   + L      +Q+  + G               ++ 
Sbjct: 1290 APKQ------EEPAENSADTGGDGESCL------SQQDGAAGV------------PETNA 1325

Query: 875  AEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHN 934
            A +SS++    +   N   + P  P+  E    L   I       LGR     + SR H+
Sbjct: 1326 AGSSSEACDFLKEDGNDEVMTPSRPRTTE---DLFAAIHRSKRKVLGRRDSDDDHSRNHS 1382

Query: 935  WTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIP------- 987
                 P  PV     APS        PK   S      K     + F   ++        
Sbjct: 1383 -----PSPPVTPTGAAPSLAS-----PKQVGSIQRSIRKSSTSSDNFKALLLKKGSRSDT 1432

Query: 988  ------------PPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALG 1035
                          P F      P+P         SP +N  +      N G   P +L 
Sbjct: 1433 SARMSAAEMLKNTDPRFQRSRSEPSPDAPESPSSCSPSKNRRAQEEWAKNEGL-MPRSLS 1491

Query: 1036 FSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQ 1095
            FS    G RY            GRS          P       +    R  SSP     +
Sbjct: 1492 FS----GPRY------------GRS--------RTPPSAASSRYSMRNRIQSSPMTVISE 1527

Query: 1096 PGGPEMRRVNSAGRAPPGGLHAPRLSLEGAAR-------------GAAEAKHKAPGSADY 1142
              G  +  V+S  R   G   A   SL+G AR              AA  + +APG  D 
Sbjct: 1528 GEGEAVEPVDSIARGALGA--AEGCSLDGLAREEMDEGGLLCGEGPAASLQPQAPGPVD- 1584

Query: 1143 GFAPAAGRSP 1152
            G A A GR P
Sbjct: 1585 GTASAEGREP 1594



 Score = 34.3 bits (77), Expect = 0.73
 Identities = 78/394 (19%), Positives = 129/394 (32%), Gaps = 86/394 (21%)

Query: 520  AKDTPPGVPEKSLGGS---SLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSS 576
            ++ T P VP    GGS    +   E +  +  PS  Y  Q +   ++  +   L      
Sbjct: 820  SRATMPQVP----GGSVKPKIMSPEKSHRVISPSSGYSSQSNTPTALTPVPVFL------ 869

Query: 577  AAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTS------ 630
               K   P+ G   PKP++           + K S   + ++   ST+L  +TS      
Sbjct: 870  ---KSVSPANGKGKPKPKVP----------ERKSSLISSVSISSSSTSLSSSTSTEGSGT 916

Query: 631  ---LQPKAMLGPAIPPKATPEPAIP------------------------PKATLWPATPP 663
               L P     PA PP   P P  P                        P + ++P  PP
Sbjct: 917  MKKLDPAVGSPPAPPPPPVPSPPFPCPADRSPFLPPPPPVTDCSQGSPLPHSPVFPPPPP 976

Query: 664  KAT----------LGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGP 713
            +A           L P  P  +   P +P+     P +  ++   P         KD+ P
Sbjct: 977  EALIPFCSPPDWCLSPPRPALSPILPDSPVSLPLPPPLLPSSEPPPAPPLDPKFMKDTRP 1036

Query: 714  ----AGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLY 769
                +GQPE  +S+    P   + E S      + T+  +     P + + G        
Sbjct: 1037 PFTNSGQPE--SSRGSLRPPSTKEETSRPPMPLITTEALQMVQLRPVRKNSGAEAAQLSE 1094

Query: 770  KPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVT 829
            +    Q +       + P+          E     +P  + +  P  A+ + +       
Sbjct: 1095 RTAQEQRTPVAPQYHLKPSAFLKSRNSTNEMESESQPASVTSSLPTPAKSSSQ----GDH 1150

Query: 830  GEVVERGSPMALLLAARQRAQKGRSVGAALGRSS 863
            G   ERG P++       R+    S G A  R S
Sbjct: 1151 GSAAERGGPVS-------RSPGAPSAGEAEARPS 1177


>gi|55750053 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 151/650 (23%), Positives = 214/650 (32%), Gaps = 102/650 (15%)

Query: 145 GPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPS----MAPPPPPVLEALSPP 200
           G + GP +    PP   P P PP + P  P    EP P  +     AP  PP       P
Sbjct: 150 GLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAP 209

Query: 201 HTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKS 260
                P  P P   + P      L+ PP       P    +  +VG    P GG      
Sbjct: 210 -----PGAPPPHPQLYPGGTGGVLSGPP-----MGPKGGGAASSVGG---PNGGKQHPPP 256

Query: 261 DVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR-SFKVPPPTPVRTSSIPVQE 319
              ++   + A+ A P + P  P G    P+  P   FP  +  +PPP  +R    P+  
Sbjct: 257 TTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALR----PLNN 312

Query: 320 AQEAPRKEEGATKKAPSRLPLPPSF-----HIRPASQVYPDRAPEPDCPGELKATAPASP 374
           A  +P       +  P  LP P +       + P  +  P  AP P       ++APA P
Sbjct: 313 ASASP--PGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPP 370

Query: 375 ------------RLGQSQSQADERAGTPPPAPPLPPPAP-PLPPPA-------PP--LPP 412
                           S S +   + +P PA    P  P   PPP        PP    P
Sbjct: 371 MRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQP 430

Query: 413 AAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRN 472
           + P      +   PP  + +   +S+    P P     ++TA           Q ++ + 
Sbjct: 431 SLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQ 490

Query: 473 ELAAYLCGSRREDRFLSHRPGPTVAPQSKEG---------------------KKGP-RLP 510
           +        +++    S  P P   P   EG                       GP  LP
Sbjct: 491 QQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLP 550

Query: 511 EKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDS-----PTPSVRQ 565
              + +S  ++  P G P  S   SS + ++ +   + PS    PQ +     P P+V  
Sbjct: 551 PPHSQVSY-SQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTT 609

Query: 566 IRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTL 625
               L   +++ A   A     S PP P   G R    GA             PP   T 
Sbjct: 610 SSATLSTVIATVASSPAGYKTAS-PPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRT- 667

Query: 626 LPTTSLQPKAMLGPAIPP--KATPEPAIPPKATLWPATPP--KATLGPATPLKATSGPTT 681
                           PP  + T  PA P   T  P +P      L PA P    S P  
Sbjct: 668 --------------GTPPGYRGTSPPAGP--GTFKPGSPTVGPGPLPPAGPSGLPSLPPP 711

Query: 682 PLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQA 731
           P    SGP +++T             E    PA  P  P  + V  PS A
Sbjct: 712 PAAPASGPPLSATQIKQEPAEEYETPESPVPPARSP-SPPPKVVDVPSHA 760



 Score = 90.5 bits (223), Expect = 9e-18
 Identities = 253/1049 (24%), Positives = 344/1049 (32%), Gaps = 219/1049 (20%)

Query: 147  APGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSP 206
            +PG  ++ S+   G  L   P+    PPPL    P PP   P  P   EA   PH    P
Sbjct: 137  SPGSVENDSDSSSG--LSQGPARPYHPPPLFPPSPQPPDSTPRQP---EASFEPH----P 187

Query: 207  SIPTPPDFIPPAPPLAFLAPPPPPVPAPAP---PAPASPHTVGTRLFPPGGVTKWKSDVA 263
            S+       P  PP + +   PP  P P P   P        G  + P GG         
Sbjct: 188  SVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGP 247

Query: 264  LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA 323
              G+Q       PP +P     S     P            PP TPV   ++P      A
Sbjct: 248  NGGKQHP-----PPTTPISVSSSGASGAPPTK---------PPTTPVGGGNLP-----SA 288

Query: 324  PRKEEGATKKAPSRLP-----LPPSFHIRP---ASQVYPDRAPEPDCPGELKATAPASPR 375
            P          P+  P     LPP   +RP   AS   P    +P  PG L    P+   
Sbjct: 289  P---------PPANFPHVTPNLPPPPALRPLNNASASPPGLGAQP-LPGHL----PSPHA 334

Query: 376  LGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAA-HPPAGFTKTP 434
            +GQ                      PP P   P L P+   LP A  +A  PP  F  + 
Sbjct: 335  MGQGMGGL-----------------PPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSS 377

Query: 435  KSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGP 494
             SSS A     +  S  ++AS  P     PS                          P P
Sbjct: 378  SSSSSA-AASSSSSSSSSSASPFPASQALPSYPHSF---------------------PPP 415

Query: 495  TVAPQSKEGKKGPRLPEKETLLSLPAKDT-PPGVPEKSLGGSSLTETEAAPSLTLPSVDY 553
            T    S +       P K T  SLP++     G P     G  L  + A P    PS   
Sbjct: 416  TSLSVSNQ-------PPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGA 468

Query: 554  IPQDSPTPSV----RQIRNELEARLSSAAEKEAKPSIGSLPPKP-----RLEGGRICENG 604
                 P  S      Q + + + +     +++ +    S PP P      LEGG      
Sbjct: 469  QSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAH 528

Query: 605  ADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPP-KATPEPAIPPKATLWPATPP 663
                  S    +  PP    L P  S    +  GP  PP  ++   +       +P + P
Sbjct: 529  PYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP 588

Query: 664  KATLGP-ATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQP----- 717
              + GP   P      P  P   TS    A+ +T + T  S     K + P G P     
Sbjct: 589  SPSQGPQGAPYPF---PPVPTVTTSS---ATLSTVIATVASSPAGYKTASPPGPPPYGKR 642

Query: 718  -EKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQS 776
               P + + +TP   +    PS  T  P  G R        TSP  G  P  +KP     
Sbjct: 643  APSPGAYKTATPPGYKPGSPPSFRTGTP-PGYRG-------TSPPAG--PGTFKPG---- 688

Query: 777  SLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERG 836
                      PT+      GPG P+    P GLP+ PP  A P                G
Sbjct: 689  ---------SPTV------GPG-PLPPAGPSGLPSLPPPPAAPAS--------------G 718

Query: 837  SPMALLLAARQRAQKGRS----VGAALGRSSLPGSLRDHSHQAEASS-----DSIFHSQG 887
             P++     ++ A++  +    V  A   S  P  +   SH ++++      D  F+S  
Sbjct: 719  PPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCA 778

Query: 888  TPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRL------GRDAEGTELSRRHNWTKPEPQ 941
              + + V  +  K A+K + L  ++  +   R        R+ E  +   R    + E  
Sbjct: 779  RSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERS 838

Query: 942  APVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAP 1001
              +A E  AP   P   P+P     PP           E    V   PP       P  P
Sbjct: 839  VKLAQEGRAPVECPSLGPVP---HRPPF----------EPGSAVATVPPYLG----PDTP 881

Query: 1002 ALQYLGRQS-----SPPRNNYSDLRQLPNAGPGA----PPALGFSRFPAG---ARYAGAG 1049
            AL+ L   +     SP   N+     L    PG      PAL +S  PA     R A   
Sbjct: 882  ALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPAL-YSSDPAAREREREARER 940

Query: 1050 GLERFSGGGRSLIKKRLYVGEPHRGPGLP----HGGTGRSLSSPNCFGPQPGGPEMRRVN 1105
             L      G  +    L       GPGL     HGG       P    P P  P +  + 
Sbjct: 941  DLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPG-LHPFPFHPSLGPLE 999

Query: 1106 SAGRAPPGGLHAPRLSLEGAARGAAEAKH 1134
                A   G  A R  +  A R AAE +H
Sbjct: 1000 RERLALAAG-PALRPDMSYAERLAAERQH 1027



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 122/527 (23%), Positives = 165/527 (31%), Gaps = 95/527 (18%)

Query: 125 VGDLRPGQYGQDLLIP-----PPPPGPAPGPPQDI---------------SEPPGGSPLP 164
           +G L PG      L P     PP    AP PP                  S     S  P
Sbjct: 339 MGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASP 398

Query: 165 SPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDF---------- 214
            P S A P  P    PP   S++  PP   +   P   + S   P PP +          
Sbjct: 399 FPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAH 458

Query: 215 ---IPPA--------PPLAF---------------------------LAPPPPPVPAPAP 236
               PP+        PP++                             + PPPP   P P
Sbjct: 459 PGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHP 518

Query: 237 ----------PAPASPHTVGTRLFPPG--GVTKWKSDVALN--GRQAEATRASPPRSPAE 282
                     P   SP     R +PPG   +    S V+ +  G       +S   S + 
Sbjct: 519 LEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSST 578

Query: 283 PKGSALGPNPEPHLTFPRSFKVP-PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLP 341
            +GS    +P P    P+    P PP P  T+S        A      A  K  S    P
Sbjct: 579 SQGSYPCSHPSPS-QGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPP 637

Query: 342 PSFHIRPASQVYPDRAP---EPDCPGELKATAP-----ASPRLGQSQSQADERAGTPPPA 393
           P     P+   Y    P   +P  P   +   P      SP  G    +       P P 
Sbjct: 638 PYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPL 697

Query: 394 PPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENT 453
           PP  P   P  PP P  P + PPL   Q     PA   +TP+S  P  +    PP   + 
Sbjct: 698 PPAGPSGLPSLPPPPAAPASGPPLSATQ-IKQEPAEEYETPESPVPPARSPSPPPKVVDV 756

Query: 454 ASSAPVDWRDPSQMEKLRNELA-AYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEK 512
            S A    R    +++  N  A + L     E   L+ +    V    +E ++  R  EK
Sbjct: 757 PSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAR-EEK 815

Query: 513 ETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSP 559
           E       +       E+ L  S     E    +  PS+  +P   P
Sbjct: 816 EREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPP 862



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 175/859 (20%), Positives = 252/859 (29%), Gaps = 189/859 (22%)

Query: 252  PGGVTKWKSDVALN-----GRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPP 306
            PGGV+   SD          ++A    AS P+   + +   +  +       P+  K   
Sbjct: 35   PGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQ 94

Query: 307  PTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGEL 366
              P   S   +         ++G++               R   Q     +P    PG +
Sbjct: 95   ELPRPQSPSDLDSLDGRSLNDDGSSDP-------------RDIDQDNRSTSPSIYSPGSV 141

Query: 367  KATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHP 426
            +  + +S  L Q  ++        PP+P  P   P  P  +    P+  P         P
Sbjct: 142  ENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPP 201

Query: 427  PAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDR 486
             +   + P  + P   P+  P       S  P+  +            AA   G     +
Sbjct: 202  TSRMFQAPPGAPPP-HPQLYPGGTGGVLSGPPMGPKGGG---------AASSVGGPNGGK 251

Query: 487  FLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSL 546
               H P  T    S  G  G          + P K  PP  P   +GG +L    A P  
Sbjct: 252  --QHPPPTTPISVSSSGASG----------APPTK--PPTTP---VGGGNL--PSAPPPA 292

Query: 547  TLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGAD 606
              P V   P   P P++R + N             + P +G+ P    L        G  
Sbjct: 293  NFPHV--TPNLPPPPALRPLNN----------ASASPPGLGAQPLPGHLPSPHAMGQGMG 340

Query: 607  DDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEP-AIPPKATLWPATPPKA 665
                       LPP                 GP   P   P P ++PP ++  PA P + 
Sbjct: 341  ----------GLPP-----------------GPEKGPTLAPSPHSLPPASSSAPAPPMRF 373

Query: 666  TLGPATPLK-ATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQE 724
                ++    A S  ++   +++ P  AS A  LP+             + QP  P   +
Sbjct: 374  PYSSSSSSSAAASSSSSSSSSSASPFPASQA--LPSYPHSFPPPTSLSVSNQP--PKYTQ 429

Query: 725  VSTPSQA---RGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSRE 781
             S PSQA   +G   P    RL          FPP T       P +   H H     ++
Sbjct: 430  PSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQ 489

Query: 782  VAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMAL 841
                             +  + ++  G    PP  A P      HP+ G       P A+
Sbjct: 490  QQQQQQ-----------QQQQQQQHHGNSGPPPPGAFP------HPLEGGSSHHAHPYAM 532

Query: 842  LLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKE 901
                                S   GSLR                          P  P  
Sbjct: 533  --------------------SPSLGSLR--------------------------PYPPGP 546

Query: 902  AEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLP 961
            A    P +    ++ GP       G  +S   N +    Q        +PS  PQG P P
Sbjct: 547  AHLPPPHSQVSYSQAGP------NGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP 600

Query: 962  KSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLR 1021
                 PP P+              +   P       PP P   Y  R  SP     +   
Sbjct: 601  ----FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPP-PYGKRAPSPGAYKTA--- 652

Query: 1022 QLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPG-LPHG 1080
              P   PG+PP+      P      G  G    +G G          G P  GPG LP  
Sbjct: 653  TPPGYKPGSPPSFRTGTPP------GYRGTSPPAGPG------TFKPGSPTVGPGPLPPA 700

Query: 1081 GTGRSLSSPNCFGPQPGGP 1099
            G     S P    P P  P
Sbjct: 701  GPSGLPSLP----PPPAAP 715



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 53/173 (30%), Positives = 64/173 (36%), Gaps = 22/173 (12%)

Query: 83  PLNAQENHGLAVPTPSVPDDFADKEVTGTS-SLVNGNLRLYSSVGDLRPGQYGQDLLIP- 140
           P  +Q   G   P P VP          T  + V  +   Y +     P  YG+    P 
Sbjct: 588 PSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPG 647

Query: 141 ----PPPPGPAPGPPQDI--SEPPG--GSPLPSPPSTAPPPPPLLLE---PPPPPSMAP- 188
                 PPG  PG P       PPG  G+  P+ P T  P  P +     PP  PS  P 
Sbjct: 648 AYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPS 707

Query: 189 -PPPPVLEALSPPHTLSSPSIPTPP-----DFIPPAPPLAFLAPPPPPVPAPA 235
            PPPP   A  PP  LS+  I   P         P PP    +PPP  V  P+
Sbjct: 708 LPPPPAAPASGPP--LSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPS 758


>gi|55750041 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 151/650 (23%), Positives = 214/650 (32%), Gaps = 102/650 (15%)

Query: 145 GPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPS----MAPPPPPVLEALSPP 200
           G + GP +    PP   P P PP + P  P    EP P  +     AP  PP       P
Sbjct: 150 GLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAP 209

Query: 201 HTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKS 260
                P  P P   + P      L+ PP       P    +  +VG    P GG      
Sbjct: 210 -----PGAPPPHPQLYPGGTGGVLSGPP-----MGPKGGGAASSVGG---PNGGKQHPPP 256

Query: 261 DVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR-SFKVPPPTPVRTSSIPVQE 319
              ++   + A+ A P + P  P G    P+  P   FP  +  +PPP  +R    P+  
Sbjct: 257 TTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALR----PLNN 312

Query: 320 AQEAPRKEEGATKKAPSRLPLPPSF-----HIRPASQVYPDRAPEPDCPGELKATAPASP 374
           A  +P       +  P  LP P +       + P  +  P  AP P       ++APA P
Sbjct: 313 ASASP--PGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPP 370

Query: 375 ------------RLGQSQSQADERAGTPPPAPPLPPPAP-PLPPPA-------PP--LPP 412
                           S S +   + +P PA    P  P   PPP        PP    P
Sbjct: 371 MRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQP 430

Query: 413 AAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRN 472
           + P      +   PP  + +   +S+    P P     ++TA           Q ++ + 
Sbjct: 431 SLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQ 490

Query: 473 ELAAYLCGSRREDRFLSHRPGPTVAPQSKEG---------------------KKGP-RLP 510
           +        +++    S  P P   P   EG                       GP  LP
Sbjct: 491 QQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLP 550

Query: 511 EKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDS-----PTPSVRQ 565
              + +S  ++  P G P  S   SS + ++ +   + PS    PQ +     P P+V  
Sbjct: 551 PPHSQVSY-SQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTT 609

Query: 566 IRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTL 625
               L   +++ A   A     S PP P   G R    GA             PP   T 
Sbjct: 610 SSATLSTVIATVASSPAGYKTAS-PPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRT- 667

Query: 626 LPTTSLQPKAMLGPAIPP--KATPEPAIPPKATLWPATPP--KATLGPATPLKATSGPTT 681
                           PP  + T  PA P   T  P +P      L PA P    S P  
Sbjct: 668 --------------GTPPGYRGTSPPAGP--GTFKPGSPTVGPGPLPPAGPSGLPSLPPP 711

Query: 682 PLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQA 731
           P    SGP +++T             E    PA  P  P  + V  PS A
Sbjct: 712 PAAPASGPPLSATQIKQEPAEEYETPESPVPPARSP-SPPPKVVDVPSHA 760



 Score = 90.5 bits (223), Expect = 9e-18
 Identities = 253/1049 (24%), Positives = 344/1049 (32%), Gaps = 219/1049 (20%)

Query: 147  APGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSP 206
            +PG  ++ S+   G  L   P+    PPPL    P PP   P  P   EA   PH    P
Sbjct: 137  SPGSVENDSDSSSG--LSQGPARPYHPPPLFPPSPQPPDSTPRQP---EASFEPH----P 187

Query: 207  SIPTPPDFIPPAPPLAFLAPPPPPVPAPAP---PAPASPHTVGTRLFPPGGVTKWKSDVA 263
            S+       P  PP + +   PP  P P P   P        G  + P GG         
Sbjct: 188  SVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGP 247

Query: 264  LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA 323
              G+Q       PP +P     S     P            PP TPV   ++P      A
Sbjct: 248  NGGKQHP-----PPTTPISVSSSGASGAPPTK---------PPTTPVGGGNLP-----SA 288

Query: 324  PRKEEGATKKAPSRLP-----LPPSFHIRP---ASQVYPDRAPEPDCPGELKATAPASPR 375
            P          P+  P     LPP   +RP   AS   P    +P  PG L    P+   
Sbjct: 289  P---------PPANFPHVTPNLPPPPALRPLNNASASPPGLGAQP-LPGHL----PSPHA 334

Query: 376  LGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAA-HPPAGFTKTP 434
            +GQ                      PP P   P L P+   LP A  +A  PP  F  + 
Sbjct: 335  MGQGMGGL-----------------PPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSS 377

Query: 435  KSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGP 494
             SSS A     +  S  ++AS  P     PS                          P P
Sbjct: 378  SSSSSA-AASSSSSSSSSSASPFPASQALPSYPHSF---------------------PPP 415

Query: 495  TVAPQSKEGKKGPRLPEKETLLSLPAKDT-PPGVPEKSLGGSSLTETEAAPSLTLPSVDY 553
            T    S +       P K T  SLP++     G P     G  L  + A P    PS   
Sbjct: 416  TSLSVSNQ-------PPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGA 468

Query: 554  IPQDSPTPSV----RQIRNELEARLSSAAEKEAKPSIGSLPPKP-----RLEGGRICENG 604
                 P  S      Q + + + +     +++ +    S PP P      LEGG      
Sbjct: 469  QSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAH 528

Query: 605  ADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPP-KATPEPAIPPKATLWPATPP 663
                  S    +  PP    L P  S    +  GP  PP  ++   +       +P + P
Sbjct: 529  PYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP 588

Query: 664  KATLGP-ATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQP----- 717
              + GP   P      P  P   TS    A+ +T + T  S     K + P G P     
Sbjct: 589  SPSQGPQGAPYPF---PPVPTVTTSS---ATLSTVIATVASSPAGYKTASPPGPPPYGKR 642

Query: 718  -EKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQS 776
               P + + +TP   +    PS  T  P  G R        TSP  G  P  +KP     
Sbjct: 643  APSPGAYKTATPPGYKPGSPPSFRTGTP-PGYRG-------TSPPAG--PGTFKPG---- 688

Query: 777  SLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERG 836
                      PT+      GPG P+    P GLP+ PP  A P                G
Sbjct: 689  ---------SPTV------GPG-PLPPAGPSGLPSLPPPPAAPAS--------------G 718

Query: 837  SPMALLLAARQRAQKGRS----VGAALGRSSLPGSLRDHSHQAEASS-----DSIFHSQG 887
             P++     ++ A++  +    V  A   S  P  +   SH ++++      D  F+S  
Sbjct: 719  PPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCA 778

Query: 888  TPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRL------GRDAEGTELSRRHNWTKPEPQ 941
              + + V  +  K A+K + L  ++  +   R        R+ E  +   R    + E  
Sbjct: 779  RSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERS 838

Query: 942  APVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAP 1001
              +A E  AP   P   P+P     PP           E    V   PP       P  P
Sbjct: 839  VKLAQEGRAPVECPSLGPVP---HRPPF----------EPGSAVATVPPYLG----PDTP 881

Query: 1002 ALQYLGRQS-----SPPRNNYSDLRQLPNAGPGA----PPALGFSRFPAG---ARYAGAG 1049
            AL+ L   +     SP   N+     L    PG      PAL +S  PA     R A   
Sbjct: 882  ALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPAL-YSSDPAAREREREARER 940

Query: 1050 GLERFSGGGRSLIKKRLYVGEPHRGPGLP----HGGTGRSLSSPNCFGPQPGGPEMRRVN 1105
             L      G  +    L       GPGL     HGG       P    P P  P +  + 
Sbjct: 941  DLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPG-LHPFPFHPSLGPLE 999

Query: 1106 SAGRAPPGGLHAPRLSLEGAARGAAEAKH 1134
                A   G  A R  +  A R AAE +H
Sbjct: 1000 RERLALAAG-PALRPDMSYAERLAAERQH 1027



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 122/527 (23%), Positives = 165/527 (31%), Gaps = 95/527 (18%)

Query: 125 VGDLRPGQYGQDLLIP-----PPPPGPAPGPPQDI---------------SEPPGGSPLP 164
           +G L PG      L P     PP    AP PP                  S     S  P
Sbjct: 339 MGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASP 398

Query: 165 SPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDF---------- 214
            P S A P  P    PP   S++  PP   +   P   + S   P PP +          
Sbjct: 399 FPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAH 458

Query: 215 ---IPPA--------PPLAF---------------------------LAPPPPPVPAPAP 236
               PP+        PP++                             + PPPP   P P
Sbjct: 459 PGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHP 518

Query: 237 ----------PAPASPHTVGTRLFPPG--GVTKWKSDVALN--GRQAEATRASPPRSPAE 282
                     P   SP     R +PPG   +    S V+ +  G       +S   S + 
Sbjct: 519 LEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSST 578

Query: 283 PKGSALGPNPEPHLTFPRSFKVP-PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLP 341
            +GS    +P P    P+    P PP P  T+S        A      A  K  S    P
Sbjct: 579 SQGSYPCSHPSPS-QGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPP 637

Query: 342 PSFHIRPASQVYPDRAP---EPDCPGELKATAP-----ASPRLGQSQSQADERAGTPPPA 393
           P     P+   Y    P   +P  P   +   P      SP  G    +       P P 
Sbjct: 638 PYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPL 697

Query: 394 PPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENT 453
           PP  P   P  PP P  P + PPL   Q     PA   +TP+S  P  +    PP   + 
Sbjct: 698 PPAGPSGLPSLPPPPAAPASGPPLSATQ-IKQEPAEEYETPESPVPPARSPSPPPKVVDV 756

Query: 454 ASSAPVDWRDPSQMEKLRNELA-AYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEK 512
            S A    R    +++  N  A + L     E   L+ +    V    +E ++  R  EK
Sbjct: 757 PSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAR-EEK 815

Query: 513 ETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSP 559
           E       +       E+ L  S     E    +  PS+  +P   P
Sbjct: 816 EREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPP 862



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 175/859 (20%), Positives = 252/859 (29%), Gaps = 189/859 (22%)

Query: 252  PGGVTKWKSDVALN-----GRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPP 306
            PGGV+   SD          ++A    AS P+   + +   +  +       P+  K   
Sbjct: 35   PGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQ 94

Query: 307  PTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGEL 366
              P   S   +         ++G++               R   Q     +P    PG +
Sbjct: 95   ELPRPQSPSDLDSLDGRSLNDDGSSDP-------------RDIDQDNRSTSPSIYSPGSV 141

Query: 367  KATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHP 426
            +  + +S  L Q  ++        PP+P  P   P  P  +    P+  P         P
Sbjct: 142  ENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPP 201

Query: 427  PAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDR 486
             +   + P  + P   P+  P       S  P+  +            AA   G     +
Sbjct: 202  TSRMFQAPPGAPPP-HPQLYPGGTGGVLSGPPMGPKGGG---------AASSVGGPNGGK 251

Query: 487  FLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSL 546
               H P  T    S  G  G          + P K  PP  P   +GG +L    A P  
Sbjct: 252  --QHPPPTTPISVSSSGASG----------APPTK--PPTTP---VGGGNL--PSAPPPA 292

Query: 547  TLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGAD 606
              P V   P   P P++R + N             + P +G+ P    L        G  
Sbjct: 293  NFPHV--TPNLPPPPALRPLNN----------ASASPPGLGAQPLPGHLPSPHAMGQGMG 340

Query: 607  DDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEP-AIPPKATLWPATPPKA 665
                       LPP                 GP   P   P P ++PP ++  PA P + 
Sbjct: 341  ----------GLPP-----------------GPEKGPTLAPSPHSLPPASSSAPAPPMRF 373

Query: 666  TLGPATPLK-ATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQE 724
                ++    A S  ++   +++ P  AS A  LP+             + QP  P   +
Sbjct: 374  PYSSSSSSSAAASSSSSSSSSSASPFPASQA--LPSYPHSFPPPTSLSVSNQP--PKYTQ 429

Query: 725  VSTPSQA---RGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSRE 781
             S PSQA   +G   P    RL          FPP T       P +   H H     ++
Sbjct: 430  PSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQ 489

Query: 782  VAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMAL 841
                             +  + ++  G    PP  A P      HP+ G       P A+
Sbjct: 490  QQQQQQ-----------QQQQQQQHHGNSGPPPPGAFP------HPLEGGSSHHAHPYAM 532

Query: 842  LLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKE 901
                                S   GSLR                          P  P  
Sbjct: 533  --------------------SPSLGSLR--------------------------PYPPGP 546

Query: 902  AEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLP 961
            A    P +    ++ GP       G  +S   N +    Q        +PS  PQG P P
Sbjct: 547  AHLPPPHSQVSYSQAGP------NGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP 600

Query: 962  KSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLR 1021
                 PP P+              +   P       PP P   Y  R  SP     +   
Sbjct: 601  ----FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPP-PYGKRAPSPGAYKTA--- 652

Query: 1022 QLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPG-LPHG 1080
              P   PG+PP+      P      G  G    +G G          G P  GPG LP  
Sbjct: 653  TPPGYKPGSPPSFRTGTPP------GYRGTSPPAGPG------TFKPGSPTVGPGPLPPA 700

Query: 1081 GTGRSLSSPNCFGPQPGGP 1099
            G     S P    P P  P
Sbjct: 701  GPSGLPSLP----PPPAAP 715



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 53/173 (30%), Positives = 64/173 (36%), Gaps = 22/173 (12%)

Query: 83  PLNAQENHGLAVPTPSVPDDFADKEVTGTS-SLVNGNLRLYSSVGDLRPGQYGQDLLIP- 140
           P  +Q   G   P P VP          T  + V  +   Y +     P  YG+    P 
Sbjct: 588 PSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPG 647

Query: 141 ----PPPPGPAPGPPQDI--SEPPG--GSPLPSPPSTAPPPPPLLLE---PPPPPSMAP- 188
                 PPG  PG P       PPG  G+  P+ P T  P  P +     PP  PS  P 
Sbjct: 648 AYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPS 707

Query: 189 -PPPPVLEALSPPHTLSSPSIPTPP-----DFIPPAPPLAFLAPPPPPVPAPA 235
            PPPP   A  PP  LS+  I   P         P PP    +PPP  V  P+
Sbjct: 708 LPPPPAAPASGPP--LSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPS 758


>gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]
          Length = 464

 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 86/299 (28%), Positives = 110/299 (36%), Gaps = 54/299 (18%)

Query: 164 PSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAF 223
           P+PPS    PP +   PPP  +  PP PP+ E+L PP     P  P PP    P+ P   
Sbjct: 218 PAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGP--- 274

Query: 224 LAPP--PPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPA 281
             PP  PPP P   PPAP   H   + + PP             G    A    PP    
Sbjct: 275 PGPPQLPPPAPGVHPPAPV-VHPPASGVHPPA-----------PGVHPPAPGVHPPAPGV 322

Query: 282 EPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLP 341
            P  S + P P P +  P +  V PP P                   G    AP   P  
Sbjct: 323 HPPTSGVHP-PAPGV-HPPAPGVHPPAP-------------------GVHPPAPGVHPPA 361

Query: 342 PSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAP 401
           P  H  P++ V+      P  PG      PA+P +        +  G  PPAP + P AP
Sbjct: 362 PGVHPPPSAGVH------PQAPG----VHPAAPAV------HPQAPGVHPPAPGMHPQAP 405

Query: 402 PLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVD 460
            + P  P + P+AP +       HP       P    P L+P      P N     P +
Sbjct: 406 GVHPQPPGVHPSAPGVHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN 464



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 94/293 (32%), Positives = 107/293 (36%), Gaps = 63/293 (21%)

Query: 140 PPPPPGPAPGPPQDISEPP----GGSPLPSPPSTAPPPPP--LLLEPPPPPSMAPPPPPV 193
           PP PP    GPP     PP    G  P P  P + PPPPP  L L P PP   AP  PP 
Sbjct: 217 PPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPG 276

Query: 194 LEALSPPHTLSSPSI-PTPPDFIPPA----PPLAFLAPPPPPVPAPAP---PAPASPHTV 245
              L PP    +P + P  P   PPA    PP   + PP P V  PAP   P  +  H  
Sbjct: 277 PPQLPPP----APGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPP 332

Query: 246 GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVP 305
              + PP                  A    PP     P    + P P P +  P S  V 
Sbjct: 333 APGVHPP------------------APGVHPPAPGVHPPAPGVHP-PAPGVHPPPSAGVH 373

Query: 306 PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAP--EPDCP 363
           P  P    + P    Q AP    G    AP   P  P  H +P   V+P  AP   P  P
Sbjct: 374 PQAPGVHPAAPAVHPQ-AP----GVHPPAPGMHPQAPGVHPQPPG-VHPS-APGVHPQPP 426

Query: 364 GELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPP 416
           G      P++P             G  PP P  P   PPLP   P   P  PP
Sbjct: 427 G----VHPSNP-------------GVHPPTPMPPMLRPPLPSEGPGNIPPPPP 462



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 58/199 (29%), Positives = 66/199 (33%), Gaps = 58/199 (29%)

Query: 256 TKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSI 315
           T W  +      Q       PP  P+ P G             P   K PPP P+     
Sbjct: 197 THWNRETKQFFLQFHFKMEKPPAPPSLPAG-------------PPGVKRPPP-PLMNGLP 242

Query: 316 PVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPR 375
           P       P   E      P  LPLPP           P   P P  P       P  P+
Sbjct: 243 P------RPPLPESLPPPPPGGLPLPPM----------PPTGPAPSGP-------PGPPQ 279

Query: 376 LGQSQSQADERAGTPPPAPPLPPPAPPLPPPA----PPLPPAAPPLPCAQKAAHPPAGFT 431
           L             PPPAP + PPAP + PPA    PP P   PP P      HPPA   
Sbjct: 280 L-------------PPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAP----GVHPPAPGV 322

Query: 432 KTPKSSSPALKPKPNPPSP 450
             P S      P  +PP+P
Sbjct: 323 HPPTSGVHPPAPGVHPPAP 341



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 39/126 (30%), Positives = 46/126 (36%), Gaps = 10/126 (7%)

Query: 130 PGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPP 189
           PG +     + PP PG  P  P     PP     P  P   PP P   + PPP   + P 
Sbjct: 320 PGVHPPTSGVHPPAPGVHPPAPG--VHPPAPGVHPPAPGVHPPAPG--VHPPPSAGVHPQ 375

Query: 190 PPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAP---PAPASPHTVG 246
            P V  A    H  +    P  P   P AP    + P PP V   AP   P P   H   
Sbjct: 376 APGVHPAAPAVHPQAPGVHPPAPGMHPQAPG---VHPQPPGVHPSAPGVHPQPPGVHPSN 432

Query: 247 TRLFPP 252
             + PP
Sbjct: 433 PGVHPP 438



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 29/67 (43%), Positives = 33/67 (49%), Gaps = 6/67 (8%)

Query: 130 PGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPP-PLLLEPPPP---PS 185
           PG + Q   + P PPG  P  P    +PPG    PS P   PP P P +L PP P   P 
Sbjct: 398 PGMHPQAPGVHPQPPGVHPSAPGVHPQPPGVH--PSNPGVHPPTPMPPMLRPPLPSEGPG 455

Query: 186 MAPPPPP 192
             PPPPP
Sbjct: 456 NIPPPPP 462



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 41/135 (30%), Positives = 50/135 (37%), Gaps = 18/135 (13%)

Query: 123 SSVGDLRPGQYGQDLLIPPPPPGP---APG---PPQDISEPPGGSPLPSPPSTAPPPPPL 176
           S V    PG +     + PP PG    APG   P   +  PP     P  P   P  P +
Sbjct: 327 SGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPGVHPAAPAV 386

Query: 177 LLEP----PPPPSMAP------PPPPVLEALSPPHTLSSPSI-PTPPDFIPPAPPLAFLA 225
             +     PP P M P      P PP +   +P      P + P+ P   PP P    L 
Sbjct: 387 HPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPGVHPQPPGVHPSNPGVHPPTPMPPMLR 446

Query: 226 PP-PPPVPAPAPPAP 239
           PP P   P   PP P
Sbjct: 447 PPLPSEGPGNIPPPP 461



 Score = 34.3 bits (77), Expect = 0.73
 Identities = 63/247 (25%), Positives = 78/247 (31%), Gaps = 59/247 (23%)

Query: 940  PQAPVAWERVAP---SNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDP 996
            P  P   +R  P   + LP   PLP+S   PP                 +P PP     P
Sbjct: 224  PAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGG--------------LPLPPMPPTGP 269

Query: 997  EPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSG 1056
             P  P          PP        QLP   PG  P       PA   +  A G+   + 
Sbjct: 270  APSGP--------PGPP--------QLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAP 313

Query: 1057 GGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPG----GPEMRRVNSAGRAPP 1112
            G          V  P   PG+    +G    +P    P PG     P +         P 
Sbjct: 314  G----------VHPP--APGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPA 361

Query: 1113 GGLH-APRLSLEGAARG---AAEAKH-KAPGSADYGFAPAAGRSPYTTTRYGSPINTFTV 1167
             G+H  P   +   A G   AA A H +APG       PA G  P     +  P      
Sbjct: 362  PGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGV----HPPAPGMHPQAPGVHPQPPGVHPS 417

Query: 1168 RPGTRHP 1174
             PG  HP
Sbjct: 418  APGV-HP 423



 Score = 33.9 bits (76), Expect = 0.95
 Identities = 27/74 (36%), Positives = 29/74 (39%), Gaps = 18/74 (24%)

Query: 398 PPAPPLPPPAPP------------LPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKP 445
           PPAPP  P  PP            LPP  PPLP  +    PP G    P    P   P P
Sbjct: 217 PPAPPSLPAGPPGVKRPPPPLMNGLPP-RPPLP--ESLPPPPPG--GLPLPPMPPTGPAP 271

Query: 446 N-PPSPENTASSAP 458
           + PP P      AP
Sbjct: 272 SGPPGPPQLPPPAP 285


>gi|153792074 proline rich 12 [Homo sapiens]
          Length = 2036

 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 130/507 (25%), Positives = 191/507 (37%), Gaps = 90/507 (17%)

Query: 143  PPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPP---------PSMAPPPPPV 193
            P GP   P   +  PP    LPS  S   P PPLL E PPP         P   PPPPP 
Sbjct: 1419 PDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPP 1478

Query: 194  LEAL--SPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPA----------PAPPAPAS 241
              AL   PP    +PS P PP  +PP PP A  +PPPPP PA          PA P+P  
Sbjct: 1479 QPALPSPPPLVAPTPSSPPPPP-LPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPED 1537

Query: 242  PHTVGTRLFPPGGVTKWKSDVALNGR-QAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300
            P    TR   P  + K +   A+ G    EA  +       E     +     P L    
Sbjct: 1538 PELPDTR---PLHLAKKQETAAVCGETDEEAGESGGEGIFRERDEFVIRAEDIPSLKLAL 1594

Query: 301  SFKVPPPTPVRTSSIPVQ----EAQEAPRK---------EEGATKKAPSRLPLPPSFHIR 347
                 PP   R     +Q    E ++  R+           G  K    RL +    ++ 
Sbjct: 1595 QTGREPPPIWRVQKALLQKFTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVKFLENVN 1654

Query: 348  PASQV-YPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP 406
                V    R P    P  ++ +  A   +    S A      PPP  P PPP P  P  
Sbjct: 1655 KKDYVRVCARKPWHRPPVPVRRSGQAKNPVSAGGSSA------PPPKAPAPPPKPETPEK 1708

Query: 407  APPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQ 466
                            +  PP    +TP+++       P PP+PE  +   PV+     +
Sbjct: 1709 T--------------TSEKPP---EQTPETA------MPEPPAPEKPSLLRPVEKEKEKE 1745

Query: 467  M-----EKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGK---KGPRLPEKETLLSL 518
                    LR E A     +R E    + +P  +  P+++  K   + P    K+ L   
Sbjct: 1746 KVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPKKRKKWLKEA 1805

Query: 519  PAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIP-QDSPTPSVRQI-RNELEARLSS 576
                T  G P     GSS +++E++P         +P +   T ++R++ R+ +E  +S+
Sbjct: 1806 GGNATAGGGPP----GSS-SDSESSPGAPSEDERAVPGRLLKTRAMREMYRSYVEMLVST 1860

Query: 577  AAEKEAKPSIGS------LPPKPRLEG 597
            A + +   ++        LPP  +++G
Sbjct: 1861 ALDPDMIQALEDTHDELYLPPMRKIDG 1887



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 237/1031 (22%), Positives = 345/1031 (33%), Gaps = 234/1031 (22%)

Query: 140  PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSP 199
            PPPPP  A    Q     P G  L +      P  PL+L PPPP  +   P  +  A SP
Sbjct: 764  PPPPPPTA----QSTQPTPHGLLLEA----GGPDLPLVLPPPPPQLL---PSVLSHAPSP 812

Query: 200  PHTLSSPSI----PTPPDFIPPAPPLAFLAPPPPPVPAP------------APPAPASPH 243
              + S   +    P   D  P  PP     PPPPP P P             P AP+   
Sbjct: 813  SPSASKVGVHLLEPATRDGAPQPPP----PPPPPPPPMPLQLEAHLRSHGLEPAAPSPRL 868

Query: 244  TVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPA-EPKGSALGPNPE--------- 293
                 L PPG + +    +         T   PP S   +P G+   P+P+         
Sbjct: 869  RPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSPSPQGTKAPRFVP 928

Query: 294  -PHLTFP--------RSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSF 344
               + FP        RSF  P    +          +  P ++EG  K      P PP++
Sbjct: 929  LTSICFPDSLLQDEERSF-FPTMEEMFGGGAADDYGKAGPPEDEGDPKAGAGPPPGPPAY 987

Query: 345  HIRPASQVYPDRAP-----------EPDCPGELKATAPASPRLGQSQSQADERAGTPPPA 393
               P     P RA            +P+ P EL +T  A P LG  QS    +A  PPP 
Sbjct: 988  D--PYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEP-LGLIQS-GPHQAAPPPPP 1043

Query: 394  PPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPP----- 448
            PP PPPA    P + P      P+ C+ K         K  K+SS  L  + +PP     
Sbjct: 1044 PPPPPPA----PASEPKGGLTSPIFCSTKP-------KKLLKTSSFHLLRRRDPPFQTPK 1092

Query: 449  ---------SPENTASSAPVDWR-DPSQMEKLRNELAAYLCGSRRED-RFLSHRPGPTVA 497
                       +   +  P D R +P ++  L +   +    S   D  F    PGP   
Sbjct: 1093 KLYAQEYEFEADEDKADVPADIRLNPRRLPDLVSSCRSRPALSPLGDIDFCPPNPGPD-G 1151

Query: 498  PQ------SKEGKKGPRLP---------EKETLLSLPAKDTPP-------------GVPE 529
            P+      +K  + GP  P         E  T     +  TP              G   
Sbjct: 1152 PRRRGRKPTKAKRDGPPRPRGRPRIRPLEVPTTAGPASASTPTDGAKKPRGRGRGRGRKA 1211

Query: 530  KSLGGS----------SLTETEAAPSLTLPSVDYIP-QDSPTPSVRQIRNELEARLSSAA 578
            +  GG+           L+  +A   L   S D I   D  +      R ++EA++    
Sbjct: 1212 EEAGGTRLEPLKPLKIKLSVPKAGEGLGTSSGDAISGTDHNSLDSSLTREKIEAKIKEVE 1271

Query: 579  EKEAKPSIGSLPP-KPRLEGGR----ICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQP 633
            EK+ +   G +      L+ G+    + + G     LS P  K++PP     +P   LQP
Sbjct: 1272 EKQPEMKSGFMASFLDFLKSGKRHPPLYQAGL-TPPLSPP--KSVPPS----VPARGLQP 1324

Query: 634  KAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATP-------LKATSGPTTPLKAT 686
            +    PA+ P   P  A      L  A      LG  +P       LK          + 
Sbjct: 1325 QPPATPAV-PHPPPSGAFGLGGALEAAESEGLGLGCPSPCKRLDEELKRNLETLPSFSSD 1383

Query: 687  SGPAIASTATTLPTTTSQLMAEKD---------SGPAGQPEKPASQEVSTP-----SQAR 732
               ++A       + +S + A  D         S P G P  PA+     P       A 
Sbjct: 1384 EEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSAN 1443

Query: 733  GEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARG 792
              G+P      P    +     PP  +P     P    P   Q +L     +V PT    
Sbjct: 1444 SNGTPEP----PLLEEKPPPTPPPAPTPQPQPPP---PPPPPQPALPSPPPLVAPT---- 1492

Query: 793  GAAGPGEPVEVKEPPGLPAKP--------PASAQPTDELLRHPVTGEVVERGSPMALLLA 844
             ++ P  P+    PP +P+ P        P +A P +     P   E+ +   P+ L   
Sbjct: 1493 PSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDT-RPLHLAKK 1551

Query: 845  ARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSD------SIFHSQGTPNSFTVVPKL 898
                A  G +   A G S   G  R+       + D      ++   +  P  + V   L
Sbjct: 1552 QETAAVCGETDEEA-GESGGEGIFRERDEFVIRAEDIPSLKLALQTGREPPPIWRVQKAL 1610

Query: 899  -------PKEAEKDSPLTTEIPNKWGPRLGR-------------DAEGTELSRRHNWTKP 938
                    K+ ++    T+     +G    R               +   +  R  W +P
Sbjct: 1611 LQKFTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVKFLENVNKKDYVRVCARKPWHRP 1670

Query: 939  EPQAPVAWERVAPSNLP-----QGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993
                PV   R   +  P        P PK+ + PP P    +   E+        PPE +
Sbjct: 1671 ----PVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEK--------PPEQT 1718

Query: 994  ND---PEPPAP 1001
             +   PEPPAP
Sbjct: 1719 PETAMPEPPAP 1729



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 148/590 (25%), Positives = 206/590 (34%), Gaps = 73/590 (12%)

Query: 191  PPVLEA-LSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRL 249
            PP+ +A L+PP +        PP  +PP+ P   L P PP  PA   P P+    +G   
Sbjct: 1296 PPLYQAGLTPPLS--------PPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGG-- 1345

Query: 250  FPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTP 309
                         AL   ++E      P SP +     L  N E   T P SF       
Sbjct: 1346 -------------ALEAAESEGLGLGCP-SPCKRLDEELKRNLE---TLP-SFSSDEEDS 1387

Query: 310  VRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKAT 369
            V  +    +    A    +      P     P    + PA+ V P   P P  P      
Sbjct: 1388 VAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAV-PGPPPLPGLPSANSNG 1446

Query: 370  APASPRLGQSQSQADERAGTPPPAP-PLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPA 428
             P  P L +          TPPPAP P P P PP PPP P L P+ PPL     ++ PP 
Sbjct: 1447 TPEPPLLEEKPPP------TPPPAPTPQPQPPPPPPPPQPAL-PSPPPLVAPTPSSPPPP 1499

Query: 429  GFTKTPKSSSPALKPKPNPPS------PENTASSAPVD--WRDPSQMEKLRNELAAYLCG 480
                 P  + P+  P P P +      PE  A+ +P D    D   +   + +  A +CG
Sbjct: 1500 PLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDTRPLHLAKKQETAAVCG 1559

Query: 481  SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540
               E+   S   G     + +   +   +P  +  L    +  P    +K+L      E 
Sbjct: 1560 ETDEEAGESGGEG-IFRERDEFVIRAEDIPSLKLALQTGREPPPIWRVQKALLQKFTPEI 1618

Query: 541  EAAPSLTLPSVDYIPQ--DSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKP-RLEG 597
            +        + +Y+    D+     R     LE        +         PP P R  G
Sbjct: 1619 KDGQRQFCATSNYLGYFGDAKNRYQRLYVKFLENVNKKDYVRVCARKPWHRPPVPVRRSG 1678

Query: 598  GRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATL 657
                   A       P A   PP+  T   TTS +P        P  A PEP  P K +L
Sbjct: 1679 QAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQ----TPETAMPEPPAPEKPSL 1734

Query: 658  W-----PATPPKATLG--PATPLKATSGPTTPLK---ATSGPAIASTATTLPTTTSQLMA 707
                       K T G  P    +ATSG  T  +   AT  PA +      PT   ++ A
Sbjct: 1735 LRPVEKEKEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPT---KVKA 1791

Query: 708  EKDSGPAGQPEKPASQEVSTPSQARG--EGSPSEATRLPTQGARSSAAFP 755
            E    P  +  K   +E    + A G   GS S++   P   +    A P
Sbjct: 1792 E----PPPKKRKKWLKEAGGNATAGGGPPGSSSDSESSPGAPSEDERAVP 1837



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 248/1122 (22%), Positives = 364/1122 (32%), Gaps = 198/1122 (17%)

Query: 83   PLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLY--SSVGDLRPGQYGQDLLIP 140
            P  A  + GL   +PS+         TG S  ++G+   +  SS+G    G+     +I 
Sbjct: 515  PGPAAHSQGLPTASPSLSYS------TGHSPALSGHGGGWGPSSLGG--GGEASPSHIIR 566

Query: 141  PPPPGPAPGPPQDISEP--PG---GSPLPSPPSTAPPPP-----------------PLLL 178
            P    PA G P  +  P  PG    S L S P  APP                    LL 
Sbjct: 567  PLQSPPATGRPPGVGSPGAPGKYLSSVLASAPFLAPPGAGSYAAGAGGYKGKGDGSELLA 626

Query: 179  EPPPPPSMAPPPPP-----VLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPA 233
             P  PP+            +L+A SPP T  +  +         +  L        P   
Sbjct: 627  GPGGPPAERTEDEEFLIQHLLQAPSPPRTSGADGLVGEDGAADASKGLGGSGGAGGPPGT 686

Query: 234  PAPPAPASPH------TVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSA 287
            P   A   P        + T      G T   + + L   + +  +  P R    P+G A
Sbjct: 687  PYELAKEDPQRYHLQSVIRTSASLDEGAT---AALELGLGRLKEKKKGPERGGETPEGLA 743

Query: 288  L-----GPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP 342
                  G   +    F +    PPP P   S+ P           E      P  LP PP
Sbjct: 744  TSVVHYGAGAKELGAFLQK-SPPPPPPTAQSTQPTPHGLLL----EAGGPDLPLVLPPPP 798

Query: 343  SFHIRPASQVYPD---RAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPP 399
                    Q+ P     AP P         +P++ ++G    +   R G P P PP PPP
Sbjct: 799  P-------QLLPSVLSHAPSP---------SPSASKVGVHLLEPATRDGAPQPPPPPPPP 842

Query: 400  APPLPPPAPP------LPPAAP-PLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPS--P 450
             PP+P           L PAAP P    +++  PP    +   +  P L P P      P
Sbjct: 843  PPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEP-LPPAPGDTGVGP 901

Query: 451  ENTASSAPVD-WRDPSQM-----------------EKLRNELAAY------LCGSRREDR 486
             N+    P   +R PS                     L++E  ++      + G    D 
Sbjct: 902  PNSEGKDPAGAYRSPSPQGTKAPRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAADD 961

Query: 487  FLSHRP-----------GPTVAPQSKE-------GKKGPRLPEKETLLSLPAKDTPPGVP 528
            +    P           GP   P + +       G+     PE   L   P K  PP +P
Sbjct: 962  YGKAGPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNK--PPELP 1019

Query: 529  EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARL--SSAAEKEAKPSI 586
              ++    L   ++ P    P     P   P P+  + +  L + +  S+  +K  K S 
Sbjct: 1020 S-TVNAEPLGLIQSGPHQAAPPPPPPPPPPPAPA-SEPKGGLTSPIFCSTKPKKLLKTSS 1077

Query: 587  GSL-----PP--KPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGP 639
              L     PP   P+    +  E  AD+DK   P    L P+    L  +S + +  L P
Sbjct: 1078 FHLLRRRDPPFQTPKKLYAQEYEFEADEDKADVPADIRLNPRRLPDL-VSSCRSRPALSP 1136

Query: 640  AIPPKATPEPAIPPKATLWPATPPKATL-GPATPLKATSGPTTPLKATSGPAIASTATT- 697
                   P    P         P KA   GP  P          +  T+GPA AST T  
Sbjct: 1137 LGDIDFCPPNPGPDGPRRRGRKPTKAKRDGPPRPRGRPRIRPLEVPTTAGPASASTPTDG 1196

Query: 698  --LPTTTSQ---LMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPS-EATRLPTQGARSS 751
               P    +     AE+  G   +P KP   ++S P    G G+ S +A       +  S
Sbjct: 1197 AKKPRGRGRGRGRKAEEAGGTRLEPLKPLKIKLSVPKAGEGLGTSSGDAISGTDHNSLDS 1256

Query: 752  AAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVM-----PTLARGGAAGPGEPVEVKEP 806
            +    K      EV    +P      ++  +  +      P L + G   P  P +   P
Sbjct: 1257 SLTREKIEAKIKEVE-EKQPEMKSGFMASFLDFLKSGKRHPPLYQAGLTPPLSPPK-SVP 1314

Query: 807  PGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSS--- 863
            P +PA+      P    + HP        G  +          +   S G  LG  S   
Sbjct: 1315 PSVPARGLQPQPPATPAVPHPPPSGAFGLGGAL----------EAAESEGLGLGCPSPCK 1364

Query: 864  -----LPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGP 918
                 L  +L      +    DS+  ++    S +       +     P  T  P+  GP
Sbjct: 1365 RLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPD--GP 1422

Query: 919  RLGRDAEGTE------LSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSN 972
             L   A          L   ++   PEP  P+  E+  P+  P   P P+    PP P  
Sbjct: 1423 PLAPAAAVPGPPPLPGLPSANSNGTPEP--PLLEEKPPPTPPPAPTPQPQPPPPPPPPQP 1480

Query: 973  KREEEEEEFNFEVI---------PPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQL 1023
                                   PPPP   + P PP PA   L      P     +  +L
Sbjct: 1481 ALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPEL 1540

Query: 1024 PNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKR 1065
            P+  P     L  ++    A   G    E    GG  + ++R
Sbjct: 1541 PDTRP-----LHLAKKQETAAVCGETDEEAGESGGEGIFRER 1577



 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 195/899 (21%), Positives = 281/899 (31%), Gaps = 176/899 (19%)

Query: 277  PRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPS 336
            P S   P  SAL     P     R F VP       SS+ +Q+   +P          P+
Sbjct: 137  PGSSTFPSSSALSAYQHPASFGSRPFPVP-------SSLSLQDPPFSP----------PA 179

Query: 337  RLPLPPS--FHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAP 394
               L P    H++P+      +AP          T P+S  LG  +       G     P
Sbjct: 180  NGLLSPHDVLHLKPS------QAP----------TVPSS--LGFERLAGGGVLGPAGLGP 221

Query: 395  PLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA 454
               PP  P PP  PP P             H P  F     SS+ A   + + P   N +
Sbjct: 222  AQTPPYRPGPPDPPPPP------------RHLPTQFNLLASSSAAAAAAEQSSPQLYNFS 269

Query: 455  SSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKE------GKKGPR 508
             +AP     P +    R +        +   R  S +P P   P          G   P 
Sbjct: 270  GAAPGP--PPPERALPRQDTVI-----KHYQRPASAQPPPPPPPAHALQHYLSCGGSYPS 322

Query: 509  LPEKETLLSLP--AKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQI 566
            +  +  L   P    +  PG  E S  G S     A+   T P        +        
Sbjct: 323  MGHRANLACSPLGGGEPSPGAGEPSKAGPSGATAGASGRATGPEA------AGGGGAGGG 376

Query: 567  RNELEARLSSAAEKEAKPSIGSL------PPKPRLEGGRICENGADDDKLSKPVAKNLPP 620
                   + S   K  K   G+       PP PR      C++      L  P A     
Sbjct: 377  GGGYRPIIQSPGYKTGKGGYGAAAGGATRPPPPRSTATPKCQS------LGGPAAAYATG 430

Query: 621  QSTTL-----LPTTSLQPKAMLGPAIPPKATP--EPAIPPKATLWPATPPKATLGPATPL 673
            +++          +  QP+ +LGP    +     +     KA  +   PP+   GP  P 
Sbjct: 431  KASGAGGAGGQAYSPGQPQGLLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQPPSGPPPPG 490

Query: 674  KATSGPTTP---------LKATSGPAIASTATTLPTTTSQLMAEKDSGPA----GQPEKP 720
             AT    +P         ++    P  A+ +  LPT +  L       PA    G    P
Sbjct: 491  LATCQSYSPDQLQGQLYGVQGEPYPGPAAHSQGLPTASPSLSYSTGHSPALSGHGGGWGP 550

Query: 721  ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780
            +S          GE SPS   R P Q   ++   P   SPG         P  + SS+  
Sbjct: 551  SSLG------GGGEASPSHIIR-PLQSPPATGRPPGVGSPGA--------PGKYLSSVLA 595

Query: 781  EVAVVMPTLA------RGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVE 834
                + P  A       GG  G G+  E+   PG P  P    +  + L++H +      
Sbjct: 596  SAPFLAPPGAGSYAAGAGGYKGKGDGSELLAGPGGP--PAERTEDEEFLIQHLLQAPSPP 653

Query: 835  RGSPMALLLAARQRAQKGRSVGAALGRSSLPGS---------LRDHSHQAEASSDSIFHS 885
            R S    L+     A   + +G + G    PG+          R H      +S S+   
Sbjct: 654  RTSGADGLVGEDGAADASKGLGGSGGAGGPPGTPYELAKEDPQRYHLQSVIRTSASL--D 711

Query: 886  QGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVA 945
            +G   +  +     KE +K      E P      +     G +         P P  P A
Sbjct: 712  EGATAALELGLGRLKEKKKGPERGGETPEGLATSVVHYGAGAKELGAFLQKSPPPPPPTA 771

Query: 946  WERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPE------FSNDPEPP 999
                  S  P  H L      P  P              V+PPPP        S+ P P 
Sbjct: 772  -----QSTQPTPHGLLLEAGGPDLPL-------------VLPPPPPQLLPSVLSHAPSP- 812

Query: 1000 APALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGR 1059
            +P+   +G     P        Q P   P  PP +          +  + GLE  +   R
Sbjct: 813  SPSASKVGVHLLEPATR-DGAPQPPPPPPPPPPPMPLQL----EAHLRSHGLEPAAPSPR 867

Query: 1060 SLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAP 1118
               ++ L           P G     L +     P PG   +   NS G+ P G   +P
Sbjct: 868  LRPEESLD----------PPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSP 916



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 186/826 (22%), Positives = 262/826 (31%), Gaps = 149/826 (18%)

Query: 97  PSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAP-------- 148
           P+VP         G   L  G +   + +G  +   Y      PPPPP   P        
Sbjct: 197 PTVPSSL------GFERLAGGGVLGPAGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLAS 250

Query: 149 ----GPPQDISEPP-----GGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSP 199
                   + S P      G +P P PP  A P    +++    P+ A PPPP   A + 
Sbjct: 251 SSAAAAAAEQSSPQLYNFSGAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPAHAL 310

Query: 200 PHTLSS----PSIPTPPDFIPPAPPLAFLAPPP-PPVPAPAPPAPASPHTVGTRLFPP-- 252
            H LS     PS+    +      PL    P P    P+ A P+ A+    G    P   
Sbjct: 311 QHYLSCGGSYPSMGHRANL--ACSPLGGGEPSPGAGEPSKAGPSGATAGASGRATGPEAA 368

Query: 253 ------GGVTKWKSDVALNGRQ----------AEATRASPPRSPAEPKGSALGPNPEPHL 296
                 GG   ++  +   G +            ATR  PPRS A PK  +LG     + 
Sbjct: 369 GGGGAGGGGGGYRPIIQSPGYKTGKGGYGAAAGGATRPPPPRSTATPKCQSLGGPAAAYA 428

Query: 297 TFPRS------FKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350
           T   S       +   P   +    P    Q     +     KAPS    PP        
Sbjct: 429 TGKASGAGGAGGQAYSPGQPQGLLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQ------- 481

Query: 351 QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410
              P   P P  PG L      SP   Q Q Q     G P P P       P   P+   
Sbjct: 482 ---PPSGPPP--PG-LATCQSYSP--DQLQGQLYGVQGEPYPGPAAHSQGLPTASPSLSY 533

Query: 411 PPAAPPLPCAQKAAHPPAGFTKTPKSS-SPALKPKPNPPSPENTASSAPVDWRDPSQMEK 469
                P          P+      ++S S  ++P  +PP     A+  P     P    K
Sbjct: 534 STGHSPALSGHGGGWGPSSLGGGGEASPSHIIRPLQSPP-----ATGRPPGVGSPGAPGK 588

Query: 470 LRNELAA------------YLCGS-----RREDRFLSHRPGPTVAPQSKEGK-------K 505
             + + A            Y  G+     + +   L   PG   A ++++ +       +
Sbjct: 589 YLSSVLASAPFLAPPGAGSYAAGAGGYKGKGDGSELLAGPGGPPAERTEDEEFLIQHLLQ 648

Query: 506 GPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQ 565
            P  P       L  +D       K LGGS            L   D  PQ     SV +
Sbjct: 649 APSPPRTSGADGLVGEDGAADA-SKGLGGSGGAGGPPGTPYELAKED--PQRYHLQSVIR 705

Query: 566 IRNELEARLSSAAE------KEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLP 619
               L+   ++A E      KE K         P      +   GA   +L   + K+ P
Sbjct: 706 TSASLDEGATAALELGLGRLKEKKKGPERGGETPEGLATSVVHYGAGAKELGAFLQKSPP 765

Query: 620 PQSTTLLPTTSLQPKAML----GPAIPPKATPEP--AIPPKATLWPATPPKAT------L 667
           P   T   +T   P  +L    GP +P    P P   +P   +  P+  P A+      L
Sbjct: 766 PPPPT-AQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLL 824

Query: 668 GPAT------PLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAG------ 715
            PAT      P      P  P+       + S        + +L  E+   P G      
Sbjct: 825 EPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQELL 884

Query: 716 ---QPEKPASQEVST-PSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKP 771
              +P  PA  +    P  + G+  P+ A R P+     +  F P TS        +  P
Sbjct: 885 GALEPLPPAPGDTGVGPPNSEGK-DPAGAYRSPSPQGTKAPRFVPLTS--------ICFP 935

Query: 772 HCHQSSLSREVAVVMPTLARGGAA---GPGEPVEVKEPPGLPAKPP 814
                   R     M  +  GGAA   G   P E +  P   A PP
Sbjct: 936 DSLLQDEERSFFPTMEEMFGGGAADDYGKAGPPEDEGDPKAGAGPP 981



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 73/313 (23%), Positives = 98/313 (31%), Gaps = 40/313 (12%)

Query: 110 GTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPST 169
           G S L +  L    S G   P     +L+      GP PGP          SP       
Sbjct: 67  GLSGLFDTGLHHAGSAG---PDASVMNLISALESRGPQPGPSASSLLSQFRSPSWQTAMH 123

Query: 170 APPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFI----PPAPPLAFLA 225
            P P  L +    P S   P    L A   P +  S   P P        P +PP   L 
Sbjct: 124 TPGPTELFISGALPGSSTFPSSSALSAYQHPASFGSRPFPVPSSLSLQDPPFSPPANGLL 183

Query: 226 PPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKG 285
            P   +      AP  P ++G      GGV        L   Q    R  PP  P  P+ 
Sbjct: 184 SPHDVLHLKPSQAPTVPSSLGFERLAGGGVL---GPAGLGPAQTPPYRPGPPDPPPPPR- 239

Query: 286 SALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP--- 342
                    HL  P  F +     + +SS     A+++  +    +  AP   P PP   
Sbjct: 240 ---------HL--PTQFNL-----LASSSAAAAAAEQSSPQLYNFSGAAPG--PPPPERA 281

Query: 343 --------SFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAP 394
                     + RPAS   P   P         +   + P +G   + A    G   P+P
Sbjct: 282 LPRQDTVIKHYQRPASAQPPPPPPPAHALQHYLSCGGSYPSMGHRANLACSPLGGGEPSP 341

Query: 395 PLPPPAPPLPPPA 407
               P+   P  A
Sbjct: 342 GAGEPSKAGPSGA 354



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 66/239 (27%), Positives = 84/239 (35%), Gaps = 44/239 (18%)

Query: 950  APSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIP----PPPEFSNDPEPPAPALQ- 1004
            A  + PQ +    +   PP P      ++        P    PPP     P PPA ALQ 
Sbjct: 258  AEQSSPQLYNFSGAAPGPPPPERALPRQDTVIKHYQRPASAQPPP-----PPPPAHALQH 312

Query: 1005 YLGRQSSPPRNNYSDLRQL-------PNAGPGAPPALGFSRFPAGA-------RYAGAGG 1050
            YL    S P   +             P+ G G P   G S   AGA         AG GG
Sbjct: 313  YLSCGGSYPSMGHRANLACSPLGGGEPSPGAGEPSKAGPSGATAGASGRATGPEAAGGGG 372

Query: 1051 LERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGR-----SLSSPNCFGPQPGGPEMR--- 1102
                 GG R +I+   Y      G G   GG  R     S ++P C     GGP      
Sbjct: 373  AGGGGGGYRPIIQSPGYK-TGKGGYGAAAGGATRPPPPRSTATPKC--QSLGGPAAAYAT 429

Query: 1103 -RVNSAGRA--------PPGGLHAPRLSLEGAARGAAEAKHKAPGSADYGFAPAAGRSP 1152
             + + AG A         P GL  P+   +G   G A+   KAP  +     P +G  P
Sbjct: 430  GKASGAGGAGGQAYSPGQPQGLLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQPPSGPPP 488



 Score = 34.7 bits (78), Expect = 0.56
 Identities = 44/157 (28%), Positives = 52/157 (33%), Gaps = 28/157 (17%)

Query: 141  PPPPGPAPGP-PQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLE---- 195
            PPP  PAP P P+   +     P    P TA P PP     P  PS+  P     E    
Sbjct: 1692 PPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPP----APEKPSLLRPVEKEKEKEKV 1747

Query: 196  -----------ALSPPHTLSSPSIPT---PPDFIPPAPPLAFLAPPPPPVPAPAPPAPAS 241
                       A S   T    S+ T       +P A P    A PPP            
Sbjct: 1748 TRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPKKRKKWLKEAGG 1807

Query: 242  PHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPR 278
              T G    PPG  +  +S     G  +E  RA P R
Sbjct: 1808 NATAGGG--PPGSSSDSESS---PGAPSEDERAVPGR 1839



 Score = 33.9 bits (76), Expect = 0.95
 Identities = 43/194 (22%), Positives = 57/194 (29%), Gaps = 52/194 (26%)

Query: 141  PPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPP 200
            PP P    G  ++     G S   +PP  AP PPP   +P  P       PP        
Sbjct: 1670 PPVPVRRSGQAKNPVSAGGSS---APPPKAPAPPP---KPETPEKTTSEKPP-------- 1715

Query: 201  HTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKS 260
                                        P    P PPAP  P      L  P    K K 
Sbjct: 1716 -------------------------EQTPETAMPEPPAPEKP-----SLLRPVEKEKEKE 1745

Query: 261  DVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEA 320
             V    R     RA+  R     +  A G         P + ++P   P +  + P  + 
Sbjct: 1746 KVTRGERPLRGERATSGRQTRPERSLATGQ--------PATSRLPKARPTKVKAEPPPKK 1797

Query: 321  QEAPRKEEGATKKA 334
            ++   KE G    A
Sbjct: 1798 RKKWLKEAGGNATA 1811


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.131    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,186,076
Number of Sequences: 37866
Number of extensions: 6108069
Number of successful extensions: 166565
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1439
Number of HSP's successfully gapped in prelim test: 2338
Number of HSP's that attempted gapping in prelim test: 31781
Number of HSP's gapped (non-prelim): 48390
length of query: 1188
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1075
effective length of database: 13,968,660
effective search space: 15016309500
effective search space used: 15016309500
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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