Search of human proteins with 239745220

Search of human proteins with 239745220

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239745220 PREDICTED: hypothetical protein [Homo sapiens]
         (290 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239756307 PREDICTED: similar to ubiquitin-associated protein ...   598   e-171
gi|239750857 PREDICTED: similar to ubiquitin-associated protein ...   598   e-171
gi|239745220 PREDICTED: hypothetical protein [Homo sapiens]           598   e-171
gi|27502386 nuclear factor of activated T-cells, cytosolic compo...    55   9e-08
gi|7706501 WW domain binding protein 11 [Homo sapiens]                 51   1e-06
gi|46391104 hypothetical protein LOC83541 [Homo sapiens]               51   1e-06
gi|108389127 hypothetical protein LOC83541 [Homo sapiens]              51   1e-06
gi|13937401 hypothetical protein LOC83541 [Homo sapiens]               51   1e-06
gi|238859653 pleckstrin homology domain containing family A memb...    50   2e-06
gi|150170729 microtubule associated serine/threonine kinase 3 [H...    50   2e-06
gi|116235472 SH3-domain GRB2-like (endophilin) interacting prote...    50   3e-06
gi|239741585 PREDICTED: hypothetical protein XP_002342243 [Homo ...    49   4e-06
gi|239748415 PREDICTED: hypothetical protein [Homo sapiens]            49   7e-06
gi|239742343 PREDICTED: hypothetical protein XP_002342497 [Homo ...    49   7e-06
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    49   7e-06
gi|224593756 hypothetical protein LOC164127 [Homo sapiens]             48   9e-06
gi|239747312 PREDICTED: hypothetical protein XP_002346417 [Homo ...    48   9e-06
gi|239741134 PREDICTED: hypothetical protein XP_002342117 [Homo ...    48   9e-06
gi|239754458 PREDICTED: hypothetical protein [Homo sapiens]            48   1e-05
gi|239753856 PREDICTED: hypothetical protein [Homo sapiens]            48   1e-05
gi|239749008 PREDICTED: hypothetical protein XP_002346879 [Homo ...    48   1e-05
gi|239743028 PREDICTED: hypothetical protein XP_002342721 [Homo ...    48   1e-05
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    47   2e-05
gi|40353727 synaptopodin isoform A [Homo sapiens]                      47   2e-05
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]     47   2e-05
gi|45935385 SAM and SH3 domain containing 1 [Homo sapiens]             47   2e-05
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    47   2e-05
gi|72004269 tetra-peptide repeat homeobox [Homo sapiens]               47   2e-05
gi|239755710 PREDICTED: hypothetical protein [Homo sapiens]            47   3e-05
gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]                    47   3e-05

>gi|239756307 PREDICTED: similar to ubiquitin-associated protein 1
           (predicted) [Homo sapiens]
          Length = 290

 Score =  598 bits (1543), Expect = e-171
 Identities = 290/290 (100%), Positives = 290/290 (100%)

Query: 1   MNALDGVPFKLPKGFVIGTEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGP 60
           MNALDGVPFKLPKGFVIGTEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGP
Sbjct: 1   MNALDGVPFKLPKGFVIGTEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGP 60

Query: 61  SPYQCGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSE 120
           SPYQCGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSE
Sbjct: 61  SPYQCGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSE 120

Query: 121 EEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRG 180
           EEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRG
Sbjct: 121 EEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRG 180

Query: 181 HRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAP 240
           HRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAP
Sbjct: 181 HRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAP 240

Query: 241 PRPPISSPGPIIWVSSPARSLGPLLHALLHPPLTCSHLGLYRVVLLRPFD 290
           PRPPISSPGPIIWVSSPARSLGPLLHALLHPPLTCSHLGLYRVVLLRPFD
Sbjct: 241 PRPPISSPGPIIWVSSPARSLGPLLHALLHPPLTCSHLGLYRVVLLRPFD 290


>gi|239750857 PREDICTED: similar to ubiquitin-associated protein 1
           (predicted) [Homo sapiens]
          Length = 290

 Score =  598 bits (1543), Expect = e-171
 Identities = 290/290 (100%), Positives = 290/290 (100%)

Query: 1   MNALDGVPFKLPKGFVIGTEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGP 60
           MNALDGVPFKLPKGFVIGTEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGP
Sbjct: 1   MNALDGVPFKLPKGFVIGTEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGP 60

Query: 61  SPYQCGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSE 120
           SPYQCGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSE
Sbjct: 61  SPYQCGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSE 120

Query: 121 EEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRG 180
           EEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRG
Sbjct: 121 EEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRG 180

Query: 181 HRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAP 240
           HRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAP
Sbjct: 181 HRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAP 240

Query: 241 PRPPISSPGPIIWVSSPARSLGPLLHALLHPPLTCSHLGLYRVVLLRPFD 290
           PRPPISSPGPIIWVSSPARSLGPLLHALLHPPLTCSHLGLYRVVLLRPFD
Sbjct: 241 PRPPISSPGPIIWVSSPARSLGPLLHALLHPPLTCSHLGLYRVVLLRPFD 290


>gi|239745220 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 290

 Score =  598 bits (1543), Expect = e-171
 Identities = 290/290 (100%), Positives = 290/290 (100%)

Query: 1   MNALDGVPFKLPKGFVIGTEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGP 60
           MNALDGVPFKLPKGFVIGTEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGP
Sbjct: 1   MNALDGVPFKLPKGFVIGTEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGP 60

Query: 61  SPYQCGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSE 120
           SPYQCGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSE
Sbjct: 61  SPYQCGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSE 120

Query: 121 EEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRG 180
           EEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRG
Sbjct: 121 EEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRG 180

Query: 181 HRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAP 240
           HRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAP
Sbjct: 181 HRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAP 240

Query: 241 PRPPISSPGPIIWVSSPARSLGPLLHALLHPPLTCSHLGLYRVVLLRPFD 290
           PRPPISSPGPIIWVSSPARSLGPLLHALLHPPLTCSHLGLYRVVLLRPFD
Sbjct: 241 PRPPISSPGPIIWVSSPARSLGPLLHALLHPPLTCSHLGLYRVVLLRPFD 290


>gi|27502386 nuclear factor of activated T-cells, cytosolic
           component 1 isoform C [Homo sapiens]
          Length = 930

 Score = 54.7 bits (130), Expect = 9e-08
 Identities = 65/233 (27%), Positives = 84/233 (36%), Gaps = 46/233 (19%)

Query: 16  VIGTEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGPSPYQCGDPGTASAPP 75
           +I TEP    E   P CG V  G      L R   ++ +     P P  C   G    P 
Sbjct: 687 IIKTEPTDDYE-PAPTCGPVSQGLS---PLPRP--YYSQQLAMPPDPSSCLVAGFPPCPQ 740

Query: 76  AWLLL-----VSPE-HGLAPAPTT--IRDPEAGHQERPEEEGEDEAEASSGSEEEPAPSS 127
              L+     VSP+ H L+PA  T  +  P   H   P+  GE  A      ++ P P +
Sbjct: 741 RSTLMPAAPGVSPKLHDLSPAAYTKGVASPGHCHLGLPQPAGEAPAV-----QDVPRPVA 795

Query: 128 LQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRGHRALSLC 187
             PGSP  P P                 A   +++S     S P  L H        SLC
Sbjct: 796 THPGSPGQPPP-----------------ALLPQQVSAPPSSSCPPGLEH--------SLC 830

Query: 188 PSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPL--RSHKPTVAVRILP 238
           PS    P   +   P    P +PA PP       +P    R   PT   R+LP
Sbjct: 831 PSSPSPPLPPATQEPTCLQPCSPACPPATGRPQHLPSTVRRDESPTAGPRLLP 883



 Score = 37.7 bits (86), Expect = 0.012
 Identities = 22/69 (31%), Positives = 29/69 (42%), Gaps = 4/69 (5%)

Query: 180 GHRALSLCPSPAQSPRSASPPGPAPQHPAAPASPP---RPSTAGAIPPLRSHKPTVAVRI 236
           GH  L L     ++P     P P   HP +P  PP    P    A PP  S  P +   +
Sbjct: 771 GHCHLGLPQPAGEAPAVQDVPRPVATHPGSPGQPPPALLPQQVSA-PPSSSCPPGLEHSL 829

Query: 237 LPAPPRPPI 245
            P+ P PP+
Sbjct: 830 CPSSPSPPL 838



 Score = 28.9 bits (63), Expect = 5.5
 Identities = 32/112 (28%), Positives = 43/112 (38%), Gaps = 17/112 (15%)

Query: 179 RGHRALSLCPSPAQSPRSASPP---------GPAPQHPAAPASPPRPSTAGAIPPLR-SH 228
           RG  A +L  SP  SP S SP          G     PA+P +  + S  G  PP    H
Sbjct: 210 RGLGACTLLGSPRHSP-STSPRASVTEESWLGARSSRPASPCNKRKYSLNGRQPPYSPHH 268

Query: 229 KPTVAVRILPAPPRPPISSPGPIIWVSSPARSLGPLLHALLHPPLTCSHLGL 280
            PT      P+P   P  S     W+ +  +     + A ++   T S L L
Sbjct: 269 SPT------PSPHGSPRVSVTDDSWLGNTTQYTSSAIVAAINALTTDSSLDL 314


>gi|7706501 WW domain binding protein 11 [Homo sapiens]
          Length = 641

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 51/180 (28%), Positives = 70/180 (38%), Gaps = 24/180 (13%)

Query: 96  DPEAGHQERPEEEGEDEAEASSGSEEEPAPSSLQPG---SPASPGPGRRLCSLDVLRGVR 152
           + E   Q++ +EE   +  +++ S+++  P S+ P    +P  PGP      L       
Sbjct: 365 EAEKQSQKQHKEESHSDGTSTASSQQQAPPQSVPPSQIQAPPMPGPP----PLGPPPAPP 420

Query: 153 LELAGARRRLSEGKLVSRPRAL----LHGLRGHRALSLCPSPAQSPRSASPPGPAPQHPA 208
           L   G    L  G     P  L    + GLRG     L P P        PPGP P  P 
Sbjct: 421 LRPPGPPTGLPPGPPPGAPPFLRPPGMPGLRGPLPRLLPPGPPPGRPPGPPPGPPPGLP- 479

Query: 209 APASPPR-------PSTAGAIPPLR--SHKPTVAVRILPAPPR--PPISSPGPIIWVSSP 257
            P  PPR       P     IPP R    +P +   + PAPP   PP   P P +  + P
Sbjct: 480 -PGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPP 538



 Score = 32.7 bits (73), Expect = 0.38
 Identities = 24/76 (31%), Positives = 28/76 (36%), Gaps = 1/76 (1%)

Query: 189 SPAQSPRSASPPGPAPQHPAAPASP-PRPSTAGAIPPLRSHKPTVAVRILPAPPRPPISS 247
           S A S + A P    P    AP  P P P      PPLR   P   +   P P  PP   
Sbjct: 384 STASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLR 443

Query: 248 PGPIIWVSSPARSLGP 263
           P  +  +  P   L P
Sbjct: 444 PPGMPGLRGPLPRLLP 459


>gi|46391104 hypothetical protein LOC83541 [Homo sapiens]
          Length = 295

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 65/205 (31%), Positives = 79/205 (38%), Gaps = 27/205 (13%)

Query: 62  PYQCGDPGTASAP--PAWLLLVSPEHGL-APAPTTIRDPEAGHQERPEEEGEDEAEASSG 118
           P     PG  SAP  P  L    P + L  PA    R P A  +   ++    ++   + 
Sbjct: 2   PVHTLSPGAPSAPALPCRLRTRVPGYLLRGPADGGARKPSAVERLEADKAKYVKSLHVAN 61

Query: 119 SEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGL 178
           + +EP    L      SP   R      VL   R  L G  RR         P+  L  L
Sbjct: 62  TRQEPVQPLLSKQPLFSPETRRT-----VLTPSRRALPGPCRR---------PQLDLDIL 107

Query: 179 RGHRALSLCPSPAQSPRSASPPGPAP-QHPAAPASPPRPSTAGAIPPLRSHKPTVAVRIL 237
                + LC SP     ++  PG A       PA+PPRP      PP  S    V VR L
Sbjct: 108 SS--LIDLCDSPVSPAEASRTPGRAEGAGRPPPATPPRP------PPSTSAVRRVDVRPL 159

Query: 238 PAPPRPPISSPGPIIWVSSPARSLG 262
           PA P  P  SPGP    SSPAR  G
Sbjct: 160 PASPARPCPSPGPAA-ASSPARPPG 183


>gi|108389127 hypothetical protein LOC83541 [Homo sapiens]
          Length = 295

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 65/205 (31%), Positives = 79/205 (38%), Gaps = 27/205 (13%)

Query: 62  PYQCGDPGTASAP--PAWLLLVSPEHGL-APAPTTIRDPEAGHQERPEEEGEDEAEASSG 118
           P     PG  SAP  P  L    P + L  PA    R P A  +   ++    ++   + 
Sbjct: 2   PVHTLSPGAPSAPALPCRLRTRVPGYLLRGPADGGARKPSAVERLEADKAKYVKSLHVAN 61

Query: 119 SEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGL 178
           + +EP    L      SP   R      VL   R  L G  RR         P+  L  L
Sbjct: 62  TRQEPVQPLLSKQPLFSPETRRT-----VLTPSRRALPGPCRR---------PQLDLDIL 107

Query: 179 RGHRALSLCPSPAQSPRSASPPGPAP-QHPAAPASPPRPSTAGAIPPLRSHKPTVAVRIL 237
                + LC SP     ++  PG A       PA+PPRP      PP  S    V VR L
Sbjct: 108 SS--LIDLCDSPVSPAEASRTPGRAEGAGRPPPATPPRP------PPSTSAVRRVDVRPL 159

Query: 238 PAPPRPPISSPGPIIWVSSPARSLG 262
           PA P  P  SPGP    SSPAR  G
Sbjct: 160 PASPARPCPSPGPAA-ASSPARPPG 183


>gi|13937401 hypothetical protein LOC83541 [Homo sapiens]
          Length = 295

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 65/205 (31%), Positives = 79/205 (38%), Gaps = 27/205 (13%)

Query: 62  PYQCGDPGTASAP--PAWLLLVSPEHGL-APAPTTIRDPEAGHQERPEEEGEDEAEASSG 118
           P     PG  SAP  P  L    P + L  PA    R P A  +   ++    ++   + 
Sbjct: 2   PVHTLSPGAPSAPALPCRLRTRVPGYLLRGPADGGARKPSAVERLEADKAKYVKSLHVAN 61

Query: 119 SEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGL 178
           + +EP    L      SP   R      VL   R  L G  RR         P+  L  L
Sbjct: 62  TRQEPVQPLLSKQPLFSPETRRT-----VLTPSRRALPGPCRR---------PQLDLDIL 107

Query: 179 RGHRALSLCPSPAQSPRSASPPGPAP-QHPAAPASPPRPSTAGAIPPLRSHKPTVAVRIL 237
                + LC SP     ++  PG A       PA+PPRP      PP  S    V VR L
Sbjct: 108 SS--LIDLCDSPVSPAEASRTPGRAEGAGRPPPATPPRP------PPSTSAVRRVDVRPL 159

Query: 238 PAPPRPPISSPGPIIWVSSPARSLG 262
           PA P  P  SPGP    SSPAR  G
Sbjct: 160 PASPARPCPSPGPAA-ASSPARPPG 183


>gi|238859653 pleckstrin homology domain containing family A member
           4 isoform 2 [Homo sapiens]
          Length = 583

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 55/187 (29%), Positives = 65/187 (34%), Gaps = 25/187 (13%)

Query: 108 EGEDEAEASSGSEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKL 167
           EG+D  +  S +  +P      PG P     G      +     RL     R RL    L
Sbjct: 155 EGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRL----L 210

Query: 168 VSRPRALLH-GLRGHRA--------LSLCPSPAQSPRSASPPGPAPQHPAAPASPP-RPS 217
              P   LH GL+  RA        LS  PSP   PR  S P   P  P+   +PP RP 
Sbjct: 211 TPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPH 270

Query: 218 T----AGAIPPLRSHKPTVAVRILPAPPRPPISSPG-------PIIWVSSPARSLGPLLH 266
           T        PPL        +   P P R P S  G       P  W   P    GP L 
Sbjct: 271 TPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGPPLE 330

Query: 267 ALLHPPL 273
           +  H  L
Sbjct: 331 STFHQSL 337


>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
            sapiens]
          Length = 1309

 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 45/139 (32%), Positives = 56/139 (40%), Gaps = 35/139 (25%)

Query: 82   SPEHGLAPAPTT-IRDPEAGHQERPEEEGEDEAEASSGSEEEPAPSSLQPGSPASPGPGR 140
            SP H L+P+PTT  R P       P+   +  A   S S     PSS  P SPA+ G  R
Sbjct: 1109 SPTHSLSPSPTTPCRSPA------PDVPADTTASPPSAS-----PSSSSPASPAAAGHTR 1157

Query: 141  RLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRGHRALSLCPSPAQSPRSASPP 200
                   L G+  +L   R +    K  S               S+ PSP   P  ++PP
Sbjct: 1158 P----SSLHGLAAKLGPPRPKTGRRKSTS---------------SIPPSPLACPPISAPP 1198

Query: 201  ----GPAPQHPAAPASPPR 215
                 P P HP APA  PR
Sbjct: 1199 PRSPSPLPGHPPAPARSPR 1217



 Score = 36.2 bits (82), Expect = 0.035
 Identities = 47/152 (30%), Positives = 56/152 (36%), Gaps = 58/152 (38%)

Query: 160  RRLSEGKLVSRPRALLHGLRG-----HRALS------------LCPSPAQ---------- 192
            RR S  K +S+  ++LH  R      H +LS            L PSP            
Sbjct: 1071 RRKSLFKKISKQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVP 1130

Query: 193  -----SPRSASPPGPAPQHPAA-----PAS---------PPRPST-----AGAIPPLRSH 228
                 SP SASP   +P  PAA     P+S         PPRP T       +IPP    
Sbjct: 1131 ADTTASPPSASPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTGRRKSTSSIPP---- 1186

Query: 229  KPTVAVRILPAPPRPPISSPGPIIWVSSPARS 260
             P     I   PPR P   PG      +PARS
Sbjct: 1187 SPLACPPISAPPPRSPSPLPG---HPPAPARS 1215


>gi|116235472 SH3-domain GRB2-like (endophilin) interacting protein
           1 [Homo sapiens]
          Length = 828

 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 75/285 (26%), Positives = 105/285 (36%), Gaps = 46/285 (16%)

Query: 10  KLPKGFVIGTEPLPGPELSVPAC-----GEVLLGSMHDFSLERTALFWVEAAGQGPS--- 61
           KL + F  GT P P P  +VPA        + +G  +D S     +  + +     S   
Sbjct: 238 KLTRPFPTGTPP-PLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG 296

Query: 62  PYQCGDPGTASAPPAWLLL--VSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGS 119
           P         +A   W+     SPEH + P  T            P E+           
Sbjct: 297 PVLSPKSVAVNAEEKWVHFSDTSPEH-VTPELT------------PREKVVSPPATPDNP 343

Query: 120 EEEPAPSSLQP----GSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKL--VSRPRA 173
            + PAP  L P    G P  PGP R + S   L  V+ ++A  +  + +  L  +S P+ 
Sbjct: 344 ADSPAPGPLGPPGPTGPPGPPGPPRNVLSPLNLEEVQKKVA-EQTFIKDDYLETISSPKD 402

Query: 174 LLHGLRGHRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVA 233
              GL G RA    P P       S PGP        + P   +T+GA  P R   P V 
Sbjct: 403 F--GL-GQRATPPPPPPPTYRTVVSSPGPG-------SGPGPGTTSGASSPARPATPLVP 452

Query: 234 VRILPAPPRPPISSPGPIIWVSSP-----ARSLGPLLHALLHPPL 273
            R    PP PP     P +    P     +R   P +H+   PP+
Sbjct: 453 CRSTTPPPPPPRPPSRPKLPPGKPGVGDVSRPFSPPIHSSSPPPI 497


>gi|239741585 PREDICTED: hypothetical protein XP_002342243 [Homo
           sapiens]
          Length = 439

 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 84/275 (30%), Positives = 104/275 (37%), Gaps = 38/275 (13%)

Query: 19  TEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQG-------PSPYQCG---DP 68
           T P+P PEL     GEV   S       R A+  V AA +G       P     G   DP
Sbjct: 81  TFPVPSPELGAGREGEVAGVSACG---RRCAVLGVRAAARGQLNSRTAPRDRHRGVGPDP 137

Query: 69  G--TASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSEEEPAPS 126
           G  TA       L  SP  G        +  E G+                 S + P+P+
Sbjct: 138 GRETALGTATLSLRSSPTAGSVSTGLVGKQREGGNGPWRAPVFRLPGARLRLSSQLPSPT 197

Query: 127 SL---------QPGSPASPGPGR---RLCSLDVLRGVRLELAGARRRLSEGKLVSRPRAL 174
           +L         +PGSP+  G  R   R  +   LR     L+    RL  G    RP   
Sbjct: 198 TLPRAAPLTPYRPGSPSPRGHSRLRSRPPTRAQLRVGANPLSPVPARL-RGCHSVRPEG- 255

Query: 175 LHGLRGHRALSLCP--SPAQSPRSASPPGPAPQHPAAPA-SPPRPSTAGAIPPL--RSHK 229
             G+R  R L  CP  SP Q PR   P  P PQ  A P+    RP+ AGA P L  ++ +
Sbjct: 256 -GGVRSCRTLGCCPPTSPHQPPR--LPVTPVPQSVALPSLQSARPAAAGAAPRLSPQAAR 312

Query: 230 PTVAVRILPAPPRPPISSPGPIIWVSSPARSLGPL 264
            T      P  P PP   P P   VS+P     PL
Sbjct: 313 CTALSTEKPDRPGPPRRPPAPTP-VSAPTLRSAPL 346



 Score = 37.0 bits (84), Expect = 0.020
 Identities = 64/226 (28%), Positives = 70/226 (30%), Gaps = 60/226 (26%)

Query: 66  GDPGTASAPPA---------WLL----LVSPEHGLAPAPTT-------------IRDPEA 99
           GD G +S PP          WL     L  P  GLAP PT              +  PE 
Sbjct: 30  GDSGPSSPPPVRPSGNPEPGWLESREGLAHPPQGLAPPPTAGNRPHPTRKCTFPVPSPEL 89

Query: 100 GHQERPEEEGED-----------EAEASSGSEEEPAPSSLQPGSPASPGPGRR------- 141
           G     E  G              A A        AP     G    P PGR        
Sbjct: 90  GAGREGEVAGVSACGRRCAVLGVRAAARGQLNSRTAPRDRHRG--VGPDPGRETALGTAT 147

Query: 142 --LCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRGHRALSLCPSPAQSPRSASP 199
             L S      V   L G +R    G     P   L G R  R  S  PSP   PR+A  
Sbjct: 148 LSLRSSPTAGSVSTGLVGKQREGGNGPW-RAPVFRLPGAR-LRLSSQLPSPTTLPRAA-- 203

Query: 200 PGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAPPRPPI 245
                  P  P  P  PS  G    LRS  PT A   + A P  P+
Sbjct: 204 -------PLTPYRPGSPSPRGH-SRLRSRPPTRAQLRVGANPLSPV 241


>gi|239748415 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 208

 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 53/191 (27%), Positives = 68/191 (35%), Gaps = 29/191 (15%)

Query: 65  CGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQER------PEEEGEDEAEASSG 118
           CG PGTA  P       +P    +P    +       + R      P  + E E E   G
Sbjct: 20  CG-PGTAPPPSCGRGPETPSRSQSPKLRRVAKVAGQLRRRRLRQRDPPADREGEREVLRG 78

Query: 119 SEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGL 178
             E P P  L P    +P       S    R V  + AG RR+L++G             
Sbjct: 79  QRESPPPPQLPPELLTNPSGSAIQSSPSRFRRVPADNAGPRRQLAKG------------- 125

Query: 179 RGHRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPP---LRSHKPTVAVR 235
                + L P  A+ P  AS P   P  P    SPP P  +G   P    R +K  V   
Sbjct: 126 -----VPLRPG-AEPPAPASDPDLEPTPPGGLKSPPLPCASGQGVPGTRRRQNKLGVETL 179

Query: 236 ILPAPPRPPIS 246
           +L  P  PP S
Sbjct: 180 LLRRPQLPPHS 190


>gi|239742343 PREDICTED: hypothetical protein XP_002342497 [Homo
           sapiens]
          Length = 208

 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 53/191 (27%), Positives = 68/191 (35%), Gaps = 29/191 (15%)

Query: 65  CGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQER------PEEEGEDEAEASSG 118
           CG PGTA  P       +P    +P    +       + R      P  + E E E   G
Sbjct: 20  CG-PGTAPPPSCGRGPETPSRSQSPKLRRVAKVAGQLRRRRLRQRDPPADREGEREVLRG 78

Query: 119 SEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGL 178
             E P P  L P    +P       S    R V  + AG RR+L++G             
Sbjct: 79  QRESPPPPQLPPELLTNPSGSAIQSSPSRFRRVPADNAGPRRQLAKG------------- 125

Query: 179 RGHRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPP---LRSHKPTVAVR 235
                + L P  A+ P  AS P   P  P    SPP P  +G   P    R +K  V   
Sbjct: 126 -----VPLRPG-AEPPAPASDPDLEPTPPGGLKSPPLPCASGQGVPGTRRRQNKLGVETL 179

Query: 236 ILPAPPRPPIS 246
           +L  P  PP S
Sbjct: 180 LLRRPQLPPHS 190


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
           sapiens]
          Length = 2715

 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 72/252 (28%), Positives = 90/252 (35%), Gaps = 36/252 (14%)

Query: 60  PSPYQCGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGS 119
           P P     P   S PP        E      P T           P +  E EA A +G 
Sbjct: 431 PPPPPVSPPPLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREA-ARAGP 489

Query: 120 EEEPAPS---SLQPGSPASPGPGRRLCSLDVLRGVR---LELAGARRRLSEGKLVSRPRA 173
           E    P+   S   G P    P     S   L+ +R   + +  AR      +++  PR 
Sbjct: 490 EGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSAR----SSRVIKTPRR 545

Query: 174 LLHGLRGHRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPR----PSTAGAIPPLRS-- 227
            +      +   +  SP   P   + P P PQ PA   SPPR    PST   +P  R   
Sbjct: 546 FMDE-DPPKPPKVEVSPVLRPPITTSP-PVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSI 603

Query: 228 -HKPTVAVRIL--------PAPPRPPISSPGPIIWVSSPARSLGPLLHALLHPPLTCS-- 276
             +PT     L        PAPP PP  SP P    +    S  PLL  L  P  T S  
Sbjct: 604 LREPTFRWTSLTRELPPPPPAPPPPPAPSPPP----APATSSRRPLL--LRAPQFTPSEA 657

Query: 277 HLGLYRVVLLRP 288
           HL +Y  VL  P
Sbjct: 658 HLKIYESVLTPP 669



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 30/99 (30%), Positives = 42/99 (42%), Gaps = 13/99 (13%)

Query: 183 ALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAPPR 242
           A  + P+  +      PP   P  P+ P   P PST+   P      P V+   LP+PP 
Sbjct: 387 AEEMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPP 446

Query: 243 PPI-----SSPGPIIWVSSPARSLGPLLHALLHPPLTCS 276
           PP       SP P++  ++ +R  G        PPLT S
Sbjct: 447 PPAQEEQEESPPPVV-PATCSRKRG-------RPPLTPS 477



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 62/236 (26%), Positives = 88/236 (37%), Gaps = 39/236 (16%)

Query: 38   GSMHDFSLERTALFWVEAAGQGPSPYQCG----DPGTASAPPAWLLLVSPEHGLAPAPTT 93
            G +     + + L+W     +    Y+C      P      PA L        +  +P  
Sbjct: 1751 GRLFPIGYQCSRLYWSTVDARRRCWYRCRILEYRPWGPREEPAHLEAAEENQTIVHSPAP 1810

Query: 94   IRDPEAGHQERPEEEGEDEAEASSGSEEEPAPSS-----LQPGSPASPGPGRRLCSLDVL 148
              +P  G     E+   D      G+ E  +P       L+P S ++P P  R  S    
Sbjct: 1811 SSEPPGG-----EDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPPPAPRSFS---- 1861

Query: 149  RGVRLELAG---ARRRL---SEGKLVS--RPRALLHGLRGHRALSLCPSPAQSPRSASPP 200
             G R+++     +RR L   S G L S   P +L H +         P+P +  R  SP 
Sbjct: 1862 -GARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDF-PAPPRRSRRPSPL 1919

Query: 201  GPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILP------APPRPPISSPGP 250
             P P  P+  ASPP  ++    P LR   PT  V  L       APP P  S P P
Sbjct: 1920 APRPP-PSRWASPPLKTS----PQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPP 1970



 Score = 37.4 bits (85), Expect = 0.016
 Identities = 36/114 (31%), Positives = 46/114 (40%), Gaps = 28/114 (24%)

Query: 169  SRPRALLHGLRGHRALSLCPSPAQSPRSASP----------------------PGPAPQH 206
            +R  A L G  G R LSL P+P + P+ A+                       P P  Q 
Sbjct: 2160 TRTFAWLPGAPGVRVLSLGPAP-EPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQP 2218

Query: 207  PAAPASPPRPSTAGAIP--PLRSHKPTVAVRILPAPPRPPISSPGPIIWVSSPA 258
            P  P   P   T+  +P  PL    P V V + PAPP PP   P  ++  S PA
Sbjct: 2219 PLPPTISPTAPTSWTLPPGPLLGVLPVVGV-VRPAPPPPP--PPLTLVLSSGPA 2269



 Score = 35.8 bits (81), Expect = 0.045
 Identities = 22/68 (32%), Positives = 27/68 (39%), Gaps = 12/68 (17%)

Query: 195 RSASPPGPAPQHPAAPASPPRPSTAGAIP---------PLRSHKPTVAVRILPAP---PR 242
           R   PP PAP  P AP+ PP P+T+   P         P  +H       + P P   P 
Sbjct: 616 RELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPE 675

Query: 243 PPISSPGP 250
            P   P P
Sbjct: 676 APEPEPPP 683



 Score = 35.4 bits (80), Expect = 0.059
 Identities = 45/163 (27%), Positives = 55/163 (33%), Gaps = 22/163 (13%)

Query: 104  RPEEEGEDEAEASSGSEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLS 163
            R E    + AE +      PAPSS  PG    P     L      R   ++      R  
Sbjct: 1789 REEPAHLEAAEENQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPD 1848

Query: 164  EGKLVSRPRALLHGLRGHRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIP 223
             G   S P        G R      SP++ P      GP P  P +P+S           
Sbjct: 1849 SG---SAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPS-PGSPSS----------- 1893

Query: 224  PLRSHKPTVAVRILPAPPR------PPISSPGPIIWVSSPARS 260
             L  H PTV     PAPPR      P    P P  W S P ++
Sbjct: 1894 -LTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKT 1935



 Score = 30.0 bits (66), Expect = 2.5
 Identities = 27/80 (33%), Positives = 34/80 (42%), Gaps = 7/80 (8%)

Query: 114  EASSGSEEEPAPSSLQPGSPASPGPGRR--LCSLDVLRGVRLELAGARRRLSEGKLVSRP 171
            EASS  EE P+P   +  +P   GP  R  + S D        L GA R L E    +R 
Sbjct: 2388 EASSSEEEPPSPDDKENQAPKRTGPHLRFEISSEDGFSVEAESLEGAWRTLIEKVQEARG 2447

Query: 172  RALLH-----GLRGHRALSL 186
             A L      G+ G R L +
Sbjct: 2448 HARLRHLSFSGMSGARLLGI 2467


>gi|224593756 hypothetical protein LOC164127 [Homo sapiens]
          Length = 623

 Score = 48.1 bits (113), Expect = 9e-06
 Identities = 41/112 (36%), Positives = 48/112 (42%), Gaps = 8/112 (7%)

Query: 118 GSEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRAL-LH 176
           G+E E     L P    +P P RR CS D LRG R  L+   RR  E     RPR+  L 
Sbjct: 50  GAESEAGACWLHPHCSFTPRPRRRGCS-DSLRGSR-SLSDVARRPLERSRKHRPRSRRLE 107

Query: 177 GLRGHRALSLCPSPAQSPRSASPPG---PAPQHPAAPASPPRPSTAGAIPPL 225
              G       P PA  P++  PP    P P +P A    P P   GA  PL
Sbjct: 108 DAWGETGTK--PRPAWQPQTQLPPQRPQPCPHYPLAQGDSPPPCPGGAGTPL 157


>gi|239747312 PREDICTED: hypothetical protein XP_002346417 [Homo
           sapiens]
          Length = 144

 Score = 48.1 bits (113), Expect = 9e-06
 Identities = 42/130 (32%), Positives = 55/130 (42%), Gaps = 15/130 (11%)

Query: 150 GVRLELAGARRRLSEGKLVSRP-RALLHGLRGHRALSLCPSPAQSPRSASPPGPAPQHPA 208
           G+  E+ G RR        +RP R  + G   H A +  P+PAQ    A PPG      +
Sbjct: 9   GLGAEILGPRRPSGPASGATRPPRRRVRGSPWHAAGASFPAPAQLLLPAPPPGSRVSLGS 68

Query: 209 APASPPRPSTAGAIPPLRSHKPTVAVRILPAPPRPPISSPGPIIWVSSPARSLGPLLHAL 268
           AP  PP P+ A    P     P V +++      PP +         S ARS G LL   
Sbjct: 69  APGRPPPPALAARRAP---PAPPVLIQLRGGDAHPPPA--------FSRARSSGALLE-- 115

Query: 269 LHPPLTCSHL 278
            HP  TC+ L
Sbjct: 116 -HPGATCALL 124


>gi|239741134 PREDICTED: hypothetical protein XP_002342117 [Homo
           sapiens]
          Length = 144

 Score = 48.1 bits (113), Expect = 9e-06
 Identities = 42/130 (32%), Positives = 55/130 (42%), Gaps = 15/130 (11%)

Query: 150 GVRLELAGARRRLSEGKLVSRP-RALLHGLRGHRALSLCPSPAQSPRSASPPGPAPQHPA 208
           G+  E+ G RR        +RP R  + G   H A +  P+PAQ    A PPG      +
Sbjct: 9   GLGAEILGPRRPSGPASGATRPPRRRVRGSPWHAAGASFPAPAQLLLPAPPPGSRVSLGS 68

Query: 209 APASPPRPSTAGAIPPLRSHKPTVAVRILPAPPRPPISSPGPIIWVSSPARSLGPLLHAL 268
           AP  PP P+ A    P     P V +++      PP +         S ARS G LL   
Sbjct: 69  APGRPPPPALAARRAP---PAPPVLIQLRGGDAHPPPA--------FSRARSSGALLE-- 115

Query: 269 LHPPLTCSHL 278
            HP  TC+ L
Sbjct: 116 -HPGATCALL 124


>gi|239754458 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 180

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 52/168 (30%), Positives = 65/168 (38%), Gaps = 29/168 (17%)

Query: 109 GEDEAEASSGSEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLV 168
           GE+ A   SGS   PA     PG   SP P  R  +L  L   +    GA   L   K V
Sbjct: 6   GENAASCRSGSHFPPAARGRLPGETLSPSP--RAAALPPL---QQRPPGAPGALGRPKPV 60

Query: 169 SR-PRALLHGLRGHRALSLCPSPAQSP-RSASPPGPAPQHPAAPASPPRPSTAGAIPPLR 226
           SR PRA   GLR        P P  +P +  +P    P   + P + P P      PP  
Sbjct: 61  SRGPRA---GLREWPQQPWRPGPLGAPLQDRAPSAHVPGSASRPTATPAPPRCSRRPP-- 115

Query: 227 SHKPTVAVRILPAP-----------PRPPISSPGPIIWVSSPARSLGP 263
               T   R+ P+P           PRP   +P P   V +P R+  P
Sbjct: 116 ---TTTVSRVAPSPGRPAGLHRSREPRPQDGTPPP---VDTPPRTARP 157


>gi|239753856 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 208

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 53/191 (27%), Positives = 67/191 (35%), Gaps = 29/191 (15%)

Query: 65  CGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQER------PEEEGEDEAEASSG 118
           CG PGTA  P       +P    +P    +       + R      P  + E E E   G
Sbjct: 20  CG-PGTAPPPSCGRGPETPSRSQSPKLRRVAKVAGQLRRRRLRQRDPPADREGEREVLRG 78

Query: 119 SEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGL 178
             E P P  L P    +P       S    R V  + AG RR+L +G             
Sbjct: 79  QRESPPPPQLPPELLTNPSGSAIQSSPSRFRRVPADNAGPRRQLPKG------------- 125

Query: 179 RGHRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPP---LRSHKPTVAVR 235
                + L P  A+ P  AS P   P  P    SPP P  +G   P    R +K  V   
Sbjct: 126 -----VPLRPG-AEPPAPASDPDLEPTPPGGLKSPPLPCASGQGVPGTRRRQNKLGVETL 179

Query: 236 ILPAPPRPPIS 246
           +L  P  PP S
Sbjct: 180 LLRRPQLPPHS 190


>gi|239749008 PREDICTED: hypothetical protein XP_002346879 [Homo
           sapiens]
          Length = 180

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 52/168 (30%), Positives = 65/168 (38%), Gaps = 29/168 (17%)

Query: 109 GEDEAEASSGSEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLV 168
           GE+ A   SGS   PA     PG   SP P  R  +L  L   +    GA   L   K V
Sbjct: 6   GENAASCRSGSHFPPAARGRLPGETLSPSP--RAAALPPL---QQRPPGAPGALGRPKPV 60

Query: 169 SR-PRALLHGLRGHRALSLCPSPAQSP-RSASPPGPAPQHPAAPASPPRPSTAGAIPPLR 226
           SR PRA   GLR        P P  +P +  +P    P   + P + P P      PP  
Sbjct: 61  SRGPRA---GLREWPQQPWRPGPLGAPLQDRAPSAHVPGSASRPTATPAPPRCSRRPP-- 115

Query: 227 SHKPTVAVRILPAP-----------PRPPISSPGPIIWVSSPARSLGP 263
               T   R+ P+P           PRP   +P P   V +P R+  P
Sbjct: 116 ---TTTVSRVAPSPGRPAGLHRSREPRPQDGTPPP---VDTPPRTARP 157


>gi|239743028 PREDICTED: hypothetical protein XP_002342721 [Homo
           sapiens]
          Length = 180

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 52/168 (30%), Positives = 65/168 (38%), Gaps = 29/168 (17%)

Query: 109 GEDEAEASSGSEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLV 168
           GE+ A   SGS   PA     PG   SP P  R  +L  L   +    GA   L   K V
Sbjct: 6   GENAASCRSGSHFPPAARGRLPGETLSPSP--RAAALPPL---QQRPPGAPGALGRPKPV 60

Query: 169 SR-PRALLHGLRGHRALSLCPSPAQSP-RSASPPGPAPQHPAAPASPPRPSTAGAIPPLR 226
           SR PRA   GLR        P P  +P +  +P    P   + P + P P      PP  
Sbjct: 61  SRGPRA---GLREWPQQPWRPGPLGAPLQDRAPSAHVPGSASRPTATPAPPRCSRRPP-- 115

Query: 227 SHKPTVAVRILPAP-----------PRPPISSPGPIIWVSSPARSLGP 263
               T   R+ P+P           PRP   +P P   V +P R+  P
Sbjct: 116 ---TTTVSRVAPSPGRPAGLHRSREPRPQDGTPPP---VDTPPRTARP 157


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 59/204 (28%), Positives = 74/204 (36%), Gaps = 19/204 (9%)

Query: 60  PSPYQCGDPGTASAPPAWLLLVSPEHGL---APAPTTIR-----DPEAGHQERPEEEGED 111
           PSP +   P    APPA  L   PE      AP P         +P      +P      
Sbjct: 108 PSPRRPLVPA-GPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAAL 166

Query: 112 EAEASSGSEEEPAPS-SLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGK--LV 168
            A A  G    P P     PG PA PG  + L     L       A A   ++ G   L+
Sbjct: 167 AARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALL 226

Query: 169 SRPRALLHGLRGHRALSLCPSPAQSPRSASPP-GPAPQHPAA--PASPPRPSTAGAIPPL 225
             P+    G        +  +   +P + SPP  PAP  PAA  P  PP P+T    P  
Sbjct: 227 PLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGH 286

Query: 226 RSHKPTVAVRILPAPPRPPISSPG 249
            +  PT A    PA P P  +  G
Sbjct: 287 PAGPPTAA----PAVPPPAAAQNG 306



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 67/237 (28%), Positives = 88/237 (37%), Gaps = 54/237 (22%)

Query: 55  AAGQGPSPYQCGDPGTA-SAPPAWLLLVSPEHGLAPAPTTIRDP-------EAGHQERPE 106
           AAG GP+    G PG A   PPA            P P + R P           + RP 
Sbjct: 70  AAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPP 129

Query: 107 EEGED------EAEASSGSEEEPAPSS-LQPGSPAS------------------PGPGRR 141
            EG         A A+  +  EPAP+   +P  PA+                  PGPG+ 
Sbjct: 130 PEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGK- 188

Query: 142 LCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRGHRALSLCPSPA------QSP- 194
                   G    L G+   L+     +   +L++   G  AL   P PA      Q+P 
Sbjct: 189 ----PAGPGAAQTLNGSAALLNSHHAAAPAVSLVN--NGPAALLPLPKPAAPGTVIQTPP 242

Query: 195 --RSASPPGP-APQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAPPRPPISSP 248
              +A+PP P AP  PAAPA    P+   A PP     P    R    P  PP ++P
Sbjct: 243 FVGAAAPPAPAAPSPPAAPA----PAAPAAAPPPPPPAPATLARPPGHPAGPPTAAP 295



 Score = 35.0 bits (79), Expect = 0.077
 Identities = 28/84 (33%), Positives = 36/84 (42%), Gaps = 11/84 (13%)

Query: 172 RALLHGLRGHRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAG-AIP----PLR 226
           RA   G  G+  +S       SP  A+  GPA     AP + P P  AG A P    P R
Sbjct: 51  RAAAAGALGNHVVS------GSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQR 104

Query: 227 SHKPTVAVRILPAPPRPPISSPGP 250
              P+    ++PA P PP +   P
Sbjct: 105 PGPPSPRRPLVPAGPAPPAAKLRP 128



 Score = 33.1 bits (74), Expect = 0.29
 Identities = 56/238 (23%), Positives = 81/238 (34%), Gaps = 42/238 (17%)

Query: 18  GTEPLPGP-ELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGPSPY----QCGDPGTAS 72
           G  P PGP + + P   + L GS    +    A   V     GP+      +   PGT  
Sbjct: 179 GPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVI 238

Query: 73  APPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSEEEPAPSSLQ--P 130
             P ++   +P    AP+P     P A               A++     PAP++L   P
Sbjct: 239 QTPPFVGAAAPPAPAAPSPPAAPAPAA--------------PAAAPPPPPPAPATLARPP 284

Query: 131 GSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRGHRALSLCPSP 190
           G PA P          V      +  G+          +   A + G  G  A +  P+P
Sbjct: 285 GHPAGPPTAAPA----VPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAP 340

Query: 191 ---AQSPR---SASPPGPAPQHPAAPASPPRPSTAG-----------AIPPLRSHKPT 231
              A+SP+    A+PP       + PAS       G           A+PP     PT
Sbjct: 341 GVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPT 398



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 24/84 (28%), Positives = 31/84 (36%), Gaps = 8/84 (9%)

Query: 188 PSPAQSPRSAS-----PPGPAPQHPAAPASPPRPSTAGAIPP---LRSHKPTVAVRILPA 239
           P PA   R        P  P+P+ P  PA P  P+     PP     S  P  A   + A
Sbjct: 89  PPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAA 148

Query: 240 PPRPPISSPGPIIWVSSPARSLGP 263
            P P  + P      ++ A   GP
Sbjct: 149 GPEPAPAGPAKPAGPAALAARAGP 172



 Score = 28.9 bits (63), Expect = 5.5
 Identities = 51/239 (21%), Positives = 78/239 (32%), Gaps = 24/239 (10%)

Query: 17  IGTEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGPSPYQCGDPGTASA--- 73
           +  +P PG   + PA G      +   S +R     V+AA           P + +A   
Sbjct: 325 VSGQPGPGAAAAAPAPG------VKAESPKRV----VQAAPPAAQTLAASGPASTAASMV 374

Query: 74  --PPAWLLLVSPEHGLAPAPTTIRD-PEAGHQERPEEEGEDEAEASSGSEEEPAPSSLQP 130
             P     L SP     PAP T    P+       +         +SG      P+ L P
Sbjct: 375 IGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAP 434

Query: 131 GSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRGHRALSLCPSP 190
             P  P     + +  +  G+ L       R   G+L+  P+  L  ++        P  
Sbjct: 435 RLPQPPQNPTNIQNFQLPPGMVLV------RSENGQLLMIPQQALAQMQAQAHAQ--PQT 486

Query: 191 AQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAPPRPPISSPG 249
             +PR A+P    P   +   +P  P  A  + P    K     +    P      SPG
Sbjct: 487 TMAPRPATPTSAPPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPSATLQRSPG 545


>gi|40353727 synaptopodin isoform A [Homo sapiens]
          Length = 903

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 81/276 (29%), Positives = 109/276 (39%), Gaps = 40/276 (14%)

Query: 2   NALDGVPFKLPKGFVIGTEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGPS 61
           ++LD VP  LPKG +  +  LP P  S P     L  S    SL+ TA+          S
Sbjct: 594 SSLDLVP-NLPKGALPPSPALPRPSRSSPG----LYTSPGQDSLQPTAV----------S 638

Query: 62  PYQCGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSEE 121
           P   GD    S   AW    SP    AP P+      AG + +   E    +   +    
Sbjct: 639 PPYGGDISPVSPSRAW----SPRAKQAPRPS-FSTRNAGIEAQDRRESLPTSPPWTPGAS 693

Query: 122 EPAPSSLQ----PGSPASPGPGRRLCSLDVLRGVR-LELAGARRRLS------EGKLVSR 170
            P PSSL     PG P  PG G  + S   L     +  + + R +S      E +  SR
Sbjct: 694 RP-PSSLDGWVSPG-PWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPSR 751

Query: 171 P-RALL--HGLRGHRALSLCP--SPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPL 225
             +ALL  + +   R  S  P  + A++PR  SPP   P  P  P  PPR  +     P 
Sbjct: 752 QLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPG 811

Query: 226 RSHKPTVAVRILPAPPRP--PISSPGPIIWVSSPAR 259
            +  P  A   +P  P P  P S   P   + +P R
Sbjct: 812 SAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPR 847



 Score = 28.9 bits (63), Expect = 5.5
 Identities = 20/63 (31%), Positives = 26/63 (41%), Gaps = 9/63 (14%)

Query: 189 SPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRIL----PAPPRPP 244
           SP    R      PAPQ P+ P   PRP        + S  P V  R++    PA  R P
Sbjct: 257 SPMLERRHFGEKAPAPQPPSLPDRSPRPQR-----HIMSRSPMVERRMMGQRSPASERRP 311

Query: 245 ISS 247
           + +
Sbjct: 312 LGN 314


>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
          Length = 538

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 26/76 (34%), Positives = 35/76 (46%), Gaps = 2/76 (2%)

Query: 188 PSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRILPAPPRPPISS 247
           P+P ++PR A     A   P  PA PP P+   A  P R+  P  A     APP P  + 
Sbjct: 109 PAPPRAPRGAPAAAAAAAPPPTPAPPPPPAPVAAAAPARA--PRAAAAAATAPPSPGPAQ 166

Query: 248 PGPIIWVSSPARSLGP 263
           PGP    ++P  +  P
Sbjct: 167 PGPRAQRAAPLAAPPP 182



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 42/138 (30%), Positives = 52/138 (37%), Gaps = 14/138 (10%)

Query: 124 APSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRGHRA 183
           A ++  P +PA P P   + +    R  R   A A    S G     PRA        RA
Sbjct: 122 AAAAAPPPTPAPPPPPAPVAAAAPARAPRAAAAAATAPPSPGPAQPGPRA-------QRA 174

Query: 184 LSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPL--RSHKPTVAVRILPAPP 241
             L   P   P  A+PP  AP  PA P   P P+ A   PPL      P    +  P PP
Sbjct: 175 APLAAPP---PAPAAPPAVAP--PAGPRRAPPPAVAAREPPLPPPPQPPAPPQQQQPPPP 229

Query: 242 RPPISSPGPIIWVSSPAR 259
           +P     G  +     AR
Sbjct: 230 QPQPPPEGGAVRAGGAAR 247



 Score = 32.7 bits (73), Expect = 0.38
 Identities = 38/141 (26%), Positives = 51/141 (36%), Gaps = 22/141 (15%)

Query: 102 QERPEEEGEDEAEASSGSEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRR 161
           +E  E++ EDE E    SE    P S +P        G +   L+  RG +     A+ R
Sbjct: 328 KEEEEDDDEDEDEEDDVSEGSEVPESDRPA-------GAQHHQLNGERGPQ----SAKER 376

Query: 162 LSE--------GKLVSRPRALLHGLR---GHRALSLCPSPAQSPRSASPPGPAPQHPAAP 210
           + E        G+   R  A   G R      A++     A        P P P  P  P
Sbjct: 377 VKEWTPCGPHQGQDEGRGPAPGSGTRQVFSMAAMNKEGGTASVATGPDSPSPVPLPPGKP 436

Query: 211 ASPPRPSTAGAIPPLRSHKPT 231
           A P    T    PP R  KP+
Sbjct: 437 ALPGADGTPFGCPPGRKEKPS 457



 Score = 29.3 bits (64), Expect = 4.2
 Identities = 21/66 (31%), Positives = 27/66 (40%), Gaps = 2/66 (3%)

Query: 208 AAPASPPRPSTAGAIPPLRSHKPTVAVRILPAPPRPPISSPGPI-IWVSSPARSLGPLLH 266
           AA   PPR       PP R+ +   A     APP  P   P P  +  ++PAR+      
Sbjct: 96  AARVQPPRRGATPPAPP-RAPRGAPAAAAAAAPPPTPAPPPPPAPVAAAAPARAPRAAAA 154

Query: 267 ALLHPP 272
           A   PP
Sbjct: 155 AATAPP 160


>gi|45935385 SAM and SH3 domain containing 1 [Homo sapiens]
          Length = 1247

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 59/223 (26%), Positives = 80/223 (35%), Gaps = 56/223 (25%)

Query: 53   VEAAGQGPSPYQCGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPEEEGEDE 112
            + A+G+G SP QC      + PP        +HGLA      R P  GH++  E EG   
Sbjct: 915  IAASGRGLSPPQCLPRNYDAQPPG------AKHGLA------RTPLEGHRKGHEFEGTHH 962

Query: 113  AEASSGSEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPR 172
               +   E   A   +QP  P+ P P              +    +R RL+ G       
Sbjct: 963  PLGTK--EGVDAEQRMQPKIPSQPPP--------------VPAKKSRERLANG------- 999

Query: 173  ALLHGLRGHRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTV 232
                         L P P   P  A P   AP  P    SP  P++    PP  + +P  
Sbjct: 1000 -------------LHPVP-MGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLS 1045

Query: 233  AVRILPAPPRPPISSPGPIIWVSSPARSLGPLLHAL-LHPPLT 274
                  AP  PP + P P  W+S    +     H + L P LT
Sbjct: 1046 G----QAPGSPPSTRPPP--WLSELPENTSLQEHGVKLGPALT 1082


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
           sapiens]
          Length = 1560

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 75/293 (25%), Positives = 111/293 (37%), Gaps = 62/293 (21%)

Query: 9   FKLPKGFVIGTEPLPG-PELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGPSPYQCGD 67
           F++P     G+ P    P  + PA   VL G     +L  +A+  +        P     
Sbjct: 555 FQMPVSLAAGSLPTQSQPAPAGPAATTVLQG----VTLPPSAVAMLNTPDGLVQP---AT 607

Query: 68  PGTASAPPAWLLLVSPEHGLAPAPTT-----IRDPEAGHQERPEEEGEDEAEASSGSEEE 122
           P  A+   A +L V P     PA +T     ++ P+A  Q+ P+      A     +  +
Sbjct: 608 PAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQA--QQPPQAPTPQAAAPPQATTPQ 665

Query: 123 PAPS------SLQPGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLH 176
           P+P        +  G P S  P   + + D L+    +    +   +EG  +S P +++ 
Sbjct: 666 PSPGLASSPEKIVLGQPPSATP-TAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIV 724

Query: 177 GLRGHRALSLCPSPAQSPRSASP-----------------PGPAPQHP-AAPASPPRPST 218
                      P PAQ P  A+P                 P PAPQ P AAP   P PS+
Sbjct: 725 S---------APPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSS 775

Query: 219 AGAIP---PL--RSHKPTVAVRILPAPPRPPISSPGPIIWVSSPARSLGPLLH 266
           + ++P   PL    H P+      P P RPP   P     VS P     P LH
Sbjct: 776 SPSLPHQAPLGDSPHLPS------PHPTRPPSRPPSRPQSVSRPPSE--PPLH 820



 Score = 37.4 bits (85), Expect = 0.016
 Identities = 63/269 (23%), Positives = 91/269 (33%), Gaps = 44/269 (16%)

Query: 24  GPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGPSPYQCGDPGTASAPPAWLLLVSP 83
           GP LSVPA   V++ +         A    + AG GP   Q  D   + AP   +   +P
Sbjct: 713 GPHLSVPA--SVIVSAPPPAQDPAPATPVAKGAGLGP---QAPDSQASPAPAPQIPAAAP 767

Query: 84  EHGLAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSEEEPAPSSLQPGSPA-SPGPGRRL 142
             G  P+ +     +A   + P           S     P   S  P  P   P P  + 
Sbjct: 768 LKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQ- 826

Query: 143 CSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRGHRALSLCPSPAQSPRSASPPGP 202
            +   L G+ +     + +L      S P     G          P P   P+S  P GP
Sbjct: 827 -APPTLPGIFV----IQNQLGVPPPASNPAPTAPGP---------PQPPLRPQSQPPEGP 872

Query: 203 APQHPAAPASPPRPS------TAGAIP----------------PLRSHKPTVAVRILPAP 240
            P  P  P S    +      T+  +P                P +S  P   + ++P P
Sbjct: 873 LPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKSPTPPPTLHLVPEP 932

Query: 241 PRPPISSPGPIIWVSSPARSLGPLLHALL 269
             PP   P     V++P  +L P   ALL
Sbjct: 933 AAPPPPPPRTFQMVTTPFPAL-PQPKALL 960



 Score = 35.8 bits (81), Expect = 0.045
 Identities = 61/240 (25%), Positives = 78/240 (32%), Gaps = 46/240 (19%)

Query: 58  QGPSPYQCGDPGTASAPPAWLLLVSPEH---GLAPA--PTTIRDPEAGHQERPEEEGEDE 112
           Q P+P     P   +  P+  L  SPE    G  P+  PT I   ++     P+E  +  
Sbjct: 649 QAPTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQP 708

Query: 113 AEASSGSEEEPA------PSSLQPGSPASP-------GPGRRLCSLDVLRGVRLELAGAR 159
             A       PA      P   Q  +PA+P       GP             ++  A   
Sbjct: 709 LSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPL 768

Query: 160 RRLSEGKLVSRPRALLHGLRGH-------RALSLCPSPAQS---PRSASP--PGPAPQHP 207
           +        S P     G   H       R  S  PS  QS   P S  P  P P PQ P
Sbjct: 769 KGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAP 828

Query: 208 AA---------------PASPPRPSTAGAI-PPLRSHKPTVAVRILPAPPRPPISSPGPI 251
                            PAS P P+  G   PPLR         + PAP  PP S+   +
Sbjct: 829 PTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAV 888



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 51/187 (27%), Positives = 64/187 (34%), Gaps = 39/187 (20%)

Query: 66   GDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGH---QERPEEEGEDEAEASSGSEEE 122
            G PG     PA         G +PAP   +  EA     +E    E E       G   E
Sbjct: 1396 GGPGAPEGTPA-----GRARGGSPAPLPAKVDEATSGLIRELAAVEDELYQRMLKGPPPE 1450

Query: 123  PAPSSLQ-PGSPASPGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPR--------- 172
            PA S+ Q  G P    PG               L  A+RR SE   V +           
Sbjct: 1451 PAASAAQGTGDPDWEAPG---------------LPPAKRRKSESPDVDQASFSSDSPQDD 1495

Query: 173  ALLHGLRG--HRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKP 230
             L   L+      L+L  +P ++P   +P  P       PASPP      A PP  SH  
Sbjct: 1496 TLTEHLQSAIDSILNLQQAPGRTP---APSYPHAASAGTPASPPPLHRPEAYPP-SSHNG 1551

Query: 231  TVAVRIL 237
             +  R L
Sbjct: 1552 GLGARTL 1558


>gi|72004269 tetra-peptide repeat homeobox [Homo sapiens]
          Length = 411

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 32/78 (41%), Positives = 37/78 (47%), Gaps = 9/78 (11%)

Query: 188 PSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIP-PLRSHKPTVAVRILPAPPRPPIS 246
           P P   P S   PGP P     P S P P   G IP P+    P     ++P P   PIS
Sbjct: 208 PGPISGPISGPNPGPIPGPIPGPISGPNP---GPIPGPISGPNP----GLIPGPIPGPIS 260

Query: 247 SPGPIIW-VSSPARSLGP 263
            PGPII  + SPA+  GP
Sbjct: 261 GPGPIIGPIPSPAQIPGP 278



 Score = 35.4 bits (80), Expect = 0.059
 Identities = 28/93 (30%), Positives = 34/93 (36%), Gaps = 11/93 (11%)

Query: 177 GLRGHRALSLCPSPAQSPRSASPPGPAPQHPAAPASPPRPSTAGAIPPLRSHKPTVAVRI 236
           G R  + +    SP   P  A  PGPA      P S P P    A  P     P      
Sbjct: 81  GCRAQKGIPAALSPGPGPIPAPIPGPAQIPGPLPGSIPGPIPGPAQIPSPIPAP------ 134

Query: 237 LPAPPRPPISSPGPIIW-----VSSPARSLGPL 264
           +P P   P+  PGP        +S PA   GP+
Sbjct: 135 IPGPISGPVQIPGPFRGPIPGPISGPAPIPGPI 167



 Score = 33.9 bits (76), Expect = 0.17
 Identities = 71/296 (23%), Positives = 94/296 (31%), Gaps = 68/296 (22%)

Query: 3   ALDGVPFKLPKGFVIGTEPLPGPELSVPACGEVLLGSMHDFSLERTALFWVEAAGQGPSP 62
           A  G   +  KG      P PGP +  P  G   +      S+       +    Q PSP
Sbjct: 76  AWGGPGCRAQKGIPAALSPGPGP-IPAPIPGPAQIPGPLPGSIPGP----IPGPAQIPSP 130

Query: 63  YQCGDPGTASAP-----PAWLLLVSPEHGLAPAPTTIRDPEAGHQERP---EEEGEDEAE 114
                PG  S P     P    +  P  G AP P  I  P +G    P      G     
Sbjct: 131 IPAPIPGPISGPVQIPGPFRGPIPGPISGPAPIPGPISGPFSGPNPGPIPGPNPGPIPGP 190

Query: 115 AS-----------------------SGSEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGV 151
            S                       SG    P P  + PG  + P PG           +
Sbjct: 191 ISGPIPGPISVPIPGPIPGPISGPISGPNPGPIPGPI-PGPISGPNPGP----------I 239

Query: 152 RLELAGARRRLSEGKL---VSRPRALLHGLRGHRALSLCPSPAQSPRSASPPGPAPQHPA 208
              ++G    L  G +   +S P  ++  +         PSPAQ P      GP P    
Sbjct: 240 PGPISGPNPGLIPGPIPGPISGPGPIIGPI---------PSPAQIPGPGRLQGPGP---- 286

Query: 209 APASPPRPSTAGAIP---PLRSHKPTVAVRILPAPPRPPISSPGPI-IWVSSPARS 260
              SP R  + G++P   P+           +PAP   P S P P  +W  SP  S
Sbjct: 287 -ILSPGRMRSPGSLPGLAPILGPGSGPGSGSVPAPIPGPGSLPAPAPLWPQSPDAS 341


>gi|239755710 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 402

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 65/214 (30%), Positives = 82/214 (38%), Gaps = 36/214 (16%)

Query: 84  EHGLAPAPTTIRDP-EAGHQERPEE--EGEDEAEASSGSEEEPAPSSLQP-----GSPAS 135
           + G   AP T R   E G   R +E   G     A+ G  E       Q      G+P S
Sbjct: 51  QRGRNGAPGTQRGVREVGSPTRDQELRAGSSCGRAARGFPEPGRGGKTQKWGGGTGTPQS 110

Query: 136 PGPGRRLCSLDVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRGHRALSLCPSPAQSPR 195
           PGP        +L   +   AG R RL  G   + PR L  G     A ++ P   Q PR
Sbjct: 111 PGPCAPQALASLLGPGK---AGCRTRLQGGSSGASPRRLPGGRGPAAAFAVEPGTGQRPR 167

Query: 196 S-----ASPPGPAPQHP-----------AAPASPPRPSTAGAIPPLRSHKPTVAVRILPA 239
           +     AS  G  P  P            AP  P  P++ G    L    P+   R LP 
Sbjct: 168 NTSLAQASRSGTVPGLPPASLQPLRLPYLAPPGPHDPTSRGPGRLLTCEPPS---RKLP- 223

Query: 240 PPRPPISSPGPIIWVSSPARSLGPLLHALLHPPL 273
           PP PP  S     WV +P  ++ P L  +L PPL
Sbjct: 224 PPLPPCRSR----WVLAPPPTVRPRLR-VLTPPL 252



 Score = 32.3 bits (72), Expect = 0.50
 Identities = 41/182 (22%), Positives = 62/182 (34%), Gaps = 24/182 (13%)

Query: 54  EAAGQGPSPYQCGDPGTASAPPA-------WLLLVSPEHGLAPAPTTIRDPEAGHQERPE 106
           +   +GP      +P +   PP        W+L  +P   + P    +  P A  +  PE
Sbjct: 203 DPTSRGPGRLLTCEPPSRKLPPPLPPCRSRWVL--APPPTVRPRLRVLTPPLALRRALPE 260

Query: 107 EEGEDEAEASS---------GSEEEPAPSSLQP------GSPASPGPGRRLCSLDVLRGV 151
                 +  S+         G+E    PSS +        S     P R  CS D L   
Sbjct: 261 RGSRTPSTRSAVLSGRVAGLGTELTLTPSSRRAHGSHPLSSERQAAPTRAFCSADPLPRP 320

Query: 152 RLELAGARRRLSEGKLVSRPRALLHGLRGHRALSLCPSPAQSPRSASPPGPAPQHPAAPA 211
              +       ++G+ V +PR L   L         PSP   P  A  P    + PA+ +
Sbjct: 321 PSFVPSLPSPQAQGQAVRQPRLLRAALALGAPRGRTPSPGPGPAPALQPYTLTRFPASLS 380

Query: 212 SP 213
            P
Sbjct: 381 LP 382



 Score = 28.5 bits (62), Expect = 7.2
 Identities = 65/262 (24%), Positives = 92/262 (35%), Gaps = 41/262 (15%)

Query: 57  GQGPSPYQCGDPGTASAPPAWLLLVSPEHGLAPA--PTTIRDPEAGHQERPEEEGEDEAE 114
           G+GP+     +PGT   P    L  +   G  P   P +++     +   P     D   
Sbjct: 149 GRGPAAAFAVEPGTGQRPRNTSLAQASRSGTVPGLPPASLQPLRLPYLAPPGP--HDPTS 206

Query: 115 ASSGSEEEPAPSSLQPGSPASPGPGRRLCSLDVLRGVRLEL----AGARRRLSE--GKLV 168
              G      P S +   P  P   R + +       RL +       RR L E   +  
Sbjct: 207 RGPGRLLTCEPPSRKLPPPLPPCRSRWVLAPPPTVRPRLRVLTPPLALRRALPERGSRTP 266

Query: 169 SRPRALLHGLRG--HRALSLCPS--------PAQSPRSASP------PGPAPQHPAAPAS 212
           S   A+L G        L+L PS        P  S R A+P        P P+ P+   S
Sbjct: 267 STRSAVLSGRVAGLGTELTLTPSSRRAHGSHPLSSERQAAPTRAFCSADPLPRPPSFVPS 326

Query: 213 PPRPSTAG-AIPPLRSHKPTVAVRILPAPPRPPISSPGPIIWVSSPARSLGPLL-----H 266
            P P   G A+   R  +  +A+      PR    SPGP      PA +L P        
Sbjct: 327 LPSPQAQGQAVRQPRLLRAALAL----GAPRGRTPSPGP-----GPAPALQPYTLTRFPA 377

Query: 267 ALLHPPLTCSHLGLYRVVLLRP 288
           +L  P L  + +G   V+ L P
Sbjct: 378 SLSLPDLVFTSVGSSLVICLVP 399


>gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
          Length = 1489

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 68/224 (30%), Positives = 83/224 (37%), Gaps = 38/224 (16%)

Query: 52  WVEAAGQGPSPYQCGDPGTASAPPAWLLLVSPEHGLAPAPTTIRDPEAGHQERPE----E 107
           W       P P+    P  +SA  ++LL      G     T   DP     ER      E
Sbjct: 613 WASPLFPAPRPF----PAQSSASGSFLLSGWDPEGRGAGETLAGDPAEVLGERGTAPWVE 668

Query: 108 EGEDEAEASSGSEEEPAPSSLQPGSPASPGP-GRRLCSLDVLRGVRLELAGARRRLSEGK 166
           E E+E E SS  E+    SS   G P+  GP    LCS         E A +   L  G 
Sbjct: 669 EEEEEEEGSSPGED----SSSLGGGPSRRGPLPCPLCSR--------EGACSCLPLERGD 716

Query: 167 LVSRPRALLHGLRGHRALSLCPSPAQSPRSA-SPPGPAPQHPAAP--ASPPR---PSTAG 220
            V+       G  GH AL  CP P +   S  +  G     P AP  ++PP    P    
Sbjct: 717 AVA-------GWGGHPALG-CPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMGA 768

Query: 221 AIPPLRSHKPTVAVRILPAPPRP---PISSPGPIIWVSSPARSL 261
           A P      P  A    P PPR    P +SP P   V+SP   L
Sbjct: 769 AAPQYPGRGPPPAPPPPPPPPRAPADPAASPDPPSAVASPGSGL 812



 Score = 37.7 bits (86), Expect = 0.012
 Identities = 59/200 (29%), Positives = 76/200 (38%), Gaps = 43/200 (21%)

Query: 99   AGHQERPEEEGEDEAEASSGSEEEPAPSSLQPGSPASP-GPGRR--------LCSLDV-- 147
            AG     EE+GEDE E     EE  A     PG+ A P GPGR         + S D   
Sbjct: 1297 AGAPGPAEEDGEDEDEDEEEDEEAAA-----PGAAAGPRGPGRARAAPVPVVVSSADADA 1351

Query: 148  ---LRGVRLELAGARRRLSEGKLVSRPRALLHGLRGHRALSLC--PSPAQSPRSASPP-- 200
               LRG+     GA     E   + R R ++    G   + L    +P       +PP  
Sbjct: 1352 ARPLRGLLKSPRGADE--PEDSELERKRKMV-SFHGDVTVYLFDQETPTNELSVQAPPEG 1408

Query: 201  GPAPQHPAAPASPPRPSTAGAIPPLR------SHKPTVAVRILPAPPRPPIS----SPGP 250
               P  P AP +PP P+T G   P        S +      +LP PP PP+     S  P
Sbjct: 1409 DTDPSTPPAPPTPPHPATPGDGFPSNDSGFGGSFEWAEDFPLLP-PPGPPLCFSRFSVSP 1467

Query: 251  IIWVSSP------ARSLGPL 264
             +    P      AR  GP+
Sbjct: 1468 ALETPGPPARAPDARPAGPV 1487



 Score = 32.7 bits (73), Expect = 0.38
 Identities = 23/82 (28%), Positives = 33/82 (40%), Gaps = 6/82 (7%)

Query: 60  PSPYQCGDPGTASAPPAWLLLVSPEHGLA-PAPTTIRDPEAGHQERPEEEGEDEAEASSG 118
           P P    DP  +  PP+   + SP  GL+ P P   +  ++G++       E        
Sbjct: 787 PPPRAPADPAASPDPPS--AVASPGSGLSSPGP---KPGDSGYETETPFSPEGAFPGGGA 841

Query: 119 SEEEPAPSSLQPGSPASPGPGR 140
           +EEE  P    P  P  PG  R
Sbjct: 842 AEEEGVPRPRAPPEPPDPGAPR 863



 Score = 31.2 bits (69), Expect = 1.1
 Identities = 55/212 (25%), Positives = 71/212 (33%), Gaps = 56/212 (26%)

Query: 33  GEVLLGSMH----DFSL--ERTALFWVEAAGQGPSPYQCGDPGTASAPPAWLLLVSPEHG 86
           G   LG  H    D SL  ER +L  +  A    +P +  DP   +A P +     P  G
Sbjct: 723 GHPALGCPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMGAAAPQY-----PGRG 777

Query: 87  LAPAPTTIRDPEAGHQERPEEEGEDEAEASSGSEEEPAPSSLQPGSP-ASPGPGRRLCSL 145
             PAP             P       A A   +  +P  +   PGS  +SPGP       
Sbjct: 778 PPPAP-------------PPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGY 824

Query: 146 DVLRGVRLELAGARRRLSEGKLVSRPRALLHGLRGHRALSLCPSPAQSPRSASPPGPAPQ 205
           +       E A      +E + V RPRA                            P P 
Sbjct: 825 ETETPFSPEGAFPGGGAAEEEGVPRPRA---------------------------PPEPP 857

Query: 206 HPAAPASPPRPSTAGAIP-PLRSHKPTVAVRI 236
            P AP  PP P   G +P P    KPT  V++
Sbjct: 858 DPGAPRPPPDP---GPLPLPGPREKPTFVVQV 886



 Score = 29.3 bits (64), Expect = 4.2
 Identities = 38/140 (27%), Positives = 48/140 (34%), Gaps = 15/140 (10%)

Query: 82   SPEHGL--APAPTTIRDPEAGHQERPEEEGEDEAEASSGSEEEPAPSSLQP---GSPASP 136
            +PE  L  APAP+ +     G +  P   G     A      EP      P   G+P +P
Sbjct: 1076 APETSLERAPAPSAVVSSRNGGETAPGPLGP----APKNGTLEPGTERRAPETGGAPRAP 1131

Query: 137  GPGRRLCSLDVLRGVRLELA-GARRRLSEGKLVSRPRALLHGLRGHRALS-LCPSPAQSP 194
            G GR    LD+  G R  +  G       G  V      +   R       L P P   P
Sbjct: 1132 GAGR----LDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQP 1187

Query: 195  RSASPPGPAPQHPAAPASPP 214
            R   P  P  +   AP   P
Sbjct: 1188 RRLEPAPPRARPEVAPEGEP 1207


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.136    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,695,619
Number of Sequences: 37866
Number of extensions: 1278152
Number of successful extensions: 23375
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 652
Number of HSP's successfully gapped in prelim test: 1682
Number of HSP's that attempted gapping in prelim test: 11327
Number of HSP's gapped (non-prelim): 9187
length of query: 290
length of database: 18,247,518
effective HSP length: 101
effective length of query: 189
effective length of database: 14,423,052
effective search space: 2725956828
effective search space used: 2725956828
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.