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Search of human proteins with 23943912
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23943912 phosphoinositide-3-kinase, regulatory subunit 4
[Homo sapiens]
(1358 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23943912 phosphoinositide-3-kinase, regulatory subunit 4 [Hom... 2728 0.0
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 54 8e-07
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 53 2e-06
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 52 4e-06
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 52 4e-06
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 51 9e-06
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 51 9e-06
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 50 1e-05
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 50 1e-05
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 47 1e-04
gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Hom... 47 1e-04
gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform... 47 1e-04
gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent ... 47 1e-04
gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ... 47 1e-04
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 47 1e-04
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 46 3e-04
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 46 3e-04
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 46 3e-04
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 45 5e-04
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 45 5e-04
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 45 5e-04
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 45 5e-04
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 45 5e-04
gi|116256471 SNF1-like kinase [Homo sapiens] 45 6e-04
gi|169234742 NACHT and WD repeat domain containing 1 [Homo sapiens] 44 8e-04
gi|26665869 WD repeat domain 51B [Homo sapiens] 44 8e-04
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 44 0.001
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 44 0.001
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 44 0.001
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 44 0.001
>gi|23943912 phosphoinositide-3-kinase, regulatory subunit 4 [Homo
sapiens]
Length = 1358
Score = 2728 bits (7072), Expect = 0.0
Identities = 1358/1358 (100%), Positives = 1358/1358 (100%)
Query: 1 MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDP 60
MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDP
Sbjct: 1 MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDP 60
Query: 61 TLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFL 120
TLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFL
Sbjct: 61 TLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFL 120
Query: 121 NNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNP 180
NNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNP
Sbjct: 121 NNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNP 180
Query: 181 ADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMD 240
ADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMD
Sbjct: 181 ADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMD 240
Query: 241 IFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDK 300
IFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDK
Sbjct: 241 IFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDK 300
Query: 301 RLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGH 360
RLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGH
Sbjct: 301 RLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGH 360
Query: 361 DLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITP 420
DLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITP
Sbjct: 361 DLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITP 420
Query: 421 YLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRL 480
YLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRL
Sbjct: 421 YLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRL 480
Query: 481 AYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQK 540
AYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQK
Sbjct: 481 AYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQK 540
Query: 541 VVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDS 600
VVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDS
Sbjct: 541 VVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDS 600
Query: 601 IVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDI 660
IVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDI
Sbjct: 601 IVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDI 660
Query: 661 APFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVL 720
APFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVL
Sbjct: 661 APFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVL 720
Query: 721 KEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMT 780
KEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMT
Sbjct: 721 KEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMT 780
Query: 781 EEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEP 840
EEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEP
Sbjct: 781 EEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEP 840
Query: 841 DDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICV 900
DDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICV
Sbjct: 841 DDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICV 900
Query: 901 PLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERI 960
PLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERI
Sbjct: 901 PLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERI 960
Query: 961 AKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIW 1020
AKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIW
Sbjct: 961 AKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIW 1020
Query: 1021 NSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSP 1080
NSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSP
Sbjct: 1021 NSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSP 1080
Query: 1081 KIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLK 1140
KIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLK
Sbjct: 1081 KIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLK 1140
Query: 1141 SGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWV 1200
SGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWV
Sbjct: 1141 SGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWV 1200
Query: 1201 IAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAG 1260
IAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAG
Sbjct: 1201 IAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAG 1260
Query: 1261 SDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRG 1320
SDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRG
Sbjct: 1261 SDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRG 1320
Query: 1321 PESLPVGHHDIITDVATFQTTQGFIVTASRDGIVKVWK 1358
PESLPVGHHDIITDVATFQTTQGFIVTASRDGIVKVWK
Sbjct: 1321 PESLPVGHHDIITDVATFQTTQGFIVTASRDGIVKVWK 1358
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 54.3 bits (129), Expect = 8e-07
Identities = 42/148 (28%), Positives = 71/148 (47%), Gaps = 7/148 (4%)
Query: 24 HDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLP----LTSYKQELEELKIRLN 79
H +E ++LG + KV RA R VV + +I+ + + ++E+E + LN
Sbjct: 53 HRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMS-SLN 111
Query: 80 SAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQA 139
++ K +K ++ + LYD IS R L+ E R QI++AV
Sbjct: 112 HPHIISIYEVFENK--DKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYC 169
Query: 140 HKSGVRHGDIKTENVMVTSWNWVLLTDF 167
HK+GV H D+K EN+++ + + DF
Sbjct: 170 HKNGVVHRDLKLENILLDDNCNIKIADF 197
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 52.8 bits (125), Expect = 2e-06
Identities = 42/149 (28%), Positives = 75/149 (50%), Gaps = 10/149 (6%)
Query: 24 HDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELK--IRLNSA 81
H +E+ ++LG + KV +A+ G +V AI+ +Q+L ++ I + S+
Sbjct: 51 HRYEFLETLGKGTYGKVKKARESSGRLV----AIKSIRKDKIKDEQDLMHIRREIEIMSS 106
Query: 82 QN---CLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQ 138
N + + E +S K ++ R +LYD IS R L+ E R QI++AV
Sbjct: 107 LNHPHIIAIHEVFENSS-KIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHY 165
Query: 139 AHKSGVRHGDIKTENVMVTSWNWVLLTDF 167
H++ V H D+K EN+++ + + + DF
Sbjct: 166 CHQNRVVHRDLKLENILLDANGNIKIADF 194
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 52.0 bits (123), Expect = 4e-06
Identities = 65/279 (23%), Positives = 106/279 (37%), Gaps = 39/279 (13%)
Query: 956 NAERIAKQMMENA--EWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSN 1013
N +++A M++ W KP +R G HK AV + S L A+ S
Sbjct: 30 NTKQLASGSMDSCLMVWHMKPQSRAYRFTG--------HKDAVTCVNFSPSGHLLASGSR 81
Query: 1014 DGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEA 1073
D TV+IW ++G++T R+ V+++ FC ASD+ V++
Sbjct: 82 DKTVRIW-VPNVKGESTVFRAHT------ATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 1074 SKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAW 1133
K S H R DG ++ A+ + ++ WD SS
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDG-------------RLIVSASDDKTVKLWD--KSSREC 179
Query: 1134 TLKHDLKSGLITSFAVDIHQCWLCIGTS--SGTMACWDMRFQLPISSHCHPSRARIRRLS 1191
+ G +T VD H CI + T+ WD+R + H A + LS
Sbjct: 180 VHSYCEHGGFVT--YVDFHPSGTCIAAAGMDNTVKVWDVRTH-RLLQHYQLHSAAVNGLS 236
Query: 1192 MHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAP 1230
HP + A+ ++ + + D+ G +TL P
Sbjct: 237 FHPSGNYLITAS--SDSTLKILDLMEGRLLYTLHGHQGP 273
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 52.0 bits (123), Expect = 4e-06
Identities = 65/279 (23%), Positives = 106/279 (37%), Gaps = 39/279 (13%)
Query: 956 NAERIAKQMMENA--EWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSN 1013
N +++A M++ W KP +R G HK AV + S L A+ S
Sbjct: 30 NTKQLASGSMDSCLMVWHMKPQSRAYRFTG--------HKDAVTCVNFSPSGHLLASGSR 81
Query: 1014 DGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEA 1073
D TV+IW ++G++T R+ V+++ FC ASD+ V++
Sbjct: 82 DKTVRIW-VPNVKGESTVFRAHT------ATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 1074 SKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAW 1133
K S H R DG ++ A+ + ++ WD SS
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDG-------------RLIVSASDDKTVKLWD--KSSREC 179
Query: 1134 TLKHDLKSGLITSFAVDIHQCWLCIGTS--SGTMACWDMRFQLPISSHCHPSRARIRRLS 1191
+ G +T VD H CI + T+ WD+R + H A + LS
Sbjct: 180 VHSYCEHGGFVT--YVDFHPSGTCIAAAGMDNTVKVWDVRTH-RLLQHYQLHSAAVNGLS 236
Query: 1192 MHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAP 1230
HP + A+ ++ + + D+ G +TL P
Sbjct: 237 FHPSGNYLITAS--SDSTLKILDLMEGRLLYTLHGHQGP 273
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 50.8 bits (120), Expect = 9e-06
Identities = 54/238 (22%), Positives = 104/238 (43%), Gaps = 37/238 (15%)
Query: 23 IHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQ 82
++ FE +G + V + +H+E +V + +D + L ELK+ Q
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
Query: 83 NCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEK-RWIAFQILTAVDQAHK 141
+ K + + K ++F +YV N+ + + P EK + +Q++ A+ HK
Sbjct: 70 ENIVELKEAFRRRGKLYLVF-EYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHK 128
Query: 142 SGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPER 201
+ + H DIK EN++++ + + L DF + L E N A++ + T Y +PE
Sbjct: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFAR--NLSEGNNANYTEYVAT----RWYRSPEL 182
Query: 202 FVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLF 259
+ G + +++D++S GC++ EL ++G PLF
Sbjct: 183 LL-GAPYG---------------------------KSVDMWSVGCILGEL-SDGQPLF 211
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 50.8 bits (120), Expect = 9e-06
Identities = 54/238 (22%), Positives = 104/238 (43%), Gaps = 37/238 (15%)
Query: 23 IHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQ 82
++ FE +G + V + +H+E +V + +D + L ELK+ Q
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
Query: 83 NCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEK-RWIAFQILTAVDQAHK 141
+ K + + K ++F +YV N+ + + P EK + +Q++ A+ HK
Sbjct: 70 ENIVELKEAFRRRGKLYLVF-EYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHK 128
Query: 142 SGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPER 201
+ + H DIK EN++++ + + L DF + L E N A++ + T Y +PE
Sbjct: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFAR--NLSEGNNANYTEYVAT----RWYRSPEL 182
Query: 202 FVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLF 259
+ G + +++D++S GC++ EL ++G PLF
Sbjct: 183 LL-GAPYG---------------------------KSVDMWSVGCILGEL-SDGQPLF 211
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 50.4 bits (119), Expect = 1e-05
Identities = 62/263 (23%), Positives = 98/263 (37%), Gaps = 37/263 (14%)
Query: 970 WESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIWNSQKMEGKT 1029
W KP +R G HK AV + S L A+ S D TV+IW ++G++
Sbjct: 8 WHMKPQSRAYRFTG--------HKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGES 58
Query: 1030 TTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRI 1089
T R+ V+++ FC ASD+ V++ K S H R
Sbjct: 59 TVFRAHT------ATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRC 112
Query: 1090 LDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAV 1149
DG ++ A+ + ++ WD SS + G +T V
Sbjct: 113 AKFSPDG-------------RLIVSASDDKTVKLWD--KSSRECVHSYCEHGGFVT--YV 155
Query: 1150 DIHQCWLCIGTS--SGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGN 1207
D H CI + T+ WD+R + H A + LS HP + A+ +
Sbjct: 156 DFHPSGTCIAAAGMDNTVKVWDVRTH-RLLQHYQLHSAAVNGLSFHPSGNYLITAS--SD 212
Query: 1208 NEVSMWDMETGDRRFTLWASSAP 1230
+ + + D+ G +TL P
Sbjct: 213 STLKILDLMEGRLLYTLHGHQGP 235
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 50.4 bits (119), Expect = 1e-05
Identities = 73/318 (22%), Positives = 122/318 (38%), Gaps = 46/318 (14%)
Query: 26 FEYDKSLGSTRFFKVARAKH--REGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQN 83
+E +++G+ F KV A H +V +K+ L K E+E LK L
Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALK-NLRHQHI 69
Query: 84 CLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSG 143
C + + + K M+ L+D I ++ L+ E R + QI++AV H G
Sbjct: 70 CQLYHVL--ETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 127
Query: 144 VRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFV 203
H D+K EN++ ++ + L DF P+ N +Y T Y APE +
Sbjct: 128 YAHRDLKPENLLFDEYHKLKLIDFGLCAK---PKGNK---DYHLQTCCGSLAYAAPE-LI 180
Query: 204 DGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQ 263
G + L D++S G ++ L +P D +
Sbjct: 181 QG--------------------------KSYLGSEADVWSMGILLYVLMCGFLPFDDDNV 214
Query: 264 LLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTF 323
+ Y+ V + SI L+ QM+ +P KR+ ++ L P I +
Sbjct: 215 MALYKKIMRGKYDVPKWLSPSSIL-LLQQMLQVDPKKRISMKNLLNH------PWIMQDY 267
Query: 324 LQPYMAQFAKETFLSADE 341
P Q +K F+ D+
Sbjct: 268 NYPVEWQ-SKNPFIHLDD 284
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 47.4 bits (111), Expect = 1e-04
Identities = 70/316 (22%), Positives = 120/316 (37%), Gaps = 52/316 (16%)
Query: 5 LAGIAPS-QILSVESYFSDIHD-FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTL 62
LAG PS +L ++ + DI +E + LGS F +V A+ R +V + I L
Sbjct: 9 LAGRRPSGDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKAL 68
Query: 63 PLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNN 122
E E +R S N + + E S + L+DRI R
Sbjct: 69 RGKEALVENEIAVLRRISHPNIVALEDVHESPSH-LYLAMELVTGGELFDRIMERGSYTE 127
Query: 123 IEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTS---WNWVLLTDFASFKPTYLPEDN 179
+ + Q+L AV H G+ H D+K EN++ + + ++++DF K
Sbjct: 128 KDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSK-------- 179
Query: 180 PADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAM 239
T+ Y+APE Q+ G +A+
Sbjct: 180 -IQAGNMLGTACGTPGYVAPELL-------------------------EQKPYG---KAV 210
Query: 240 DIFSAGCVIAELFTEGVPLFD------LSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQM 293
D+++ G + L P +D SQ+L R + F + I + S ++ + +
Sbjct: 211 DVWALGVISYILLCGYPPFYDESDPELFSQIL--RASYEFDSPFWDDISE-SAKDFIRHL 267
Query: 294 IHREPDKRLEAEDYLK 309
+ R+P KR + L+
Sbjct: 268 LERDPQKRFTCQQALR 283
>gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Homo
sapiens]
Length = 1374
Score = 47.0 bits (110), Expect = 1e-04
Identities = 47/181 (25%), Positives = 75/181 (41%), Gaps = 36/181 (19%)
Query: 131 QILTAVDQAHKSGVRHGDIKTENVMVTSWNWVL-LTDFASFKPTYLPEDNPADFNYFFDT 189
QIL + H + + H DIK +NV++ +++ VL ++DF + K A N +T
Sbjct: 786 QILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSK-------RLAGINPCTET 838
Query: 190 SRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIA 249
Y+APE +D G RG +A DI+S GC I
Sbjct: 839 FTGTLQYMAPE-IIDKG------------------------PRG-YGKAADIWSLGCTII 872
Query: 250 ELFTEGVPLFDLS--QLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDY 307
E+ T P ++L Q ++ G F + + + + + +PDKR A D
Sbjct: 873 EMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDL 932
Query: 308 L 308
L
Sbjct: 933 L 933
>gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1
[Homo sapiens]
Length = 556
Score = 47.0 bits (110), Expect = 1e-04
Identities = 42/185 (22%), Positives = 79/185 (42%), Gaps = 42/185 (22%)
Query: 126 RWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNY 185
R+ +I++A++ H G+ H D+K EN+++ + +TDF + K PE A N
Sbjct: 183 RFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK-VLSPESKQARANS 241
Query: 186 FFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAG 245
F T++ Y++PE T ++ D+++ G
Sbjct: 242 FVGTAQ----YVSPELL----------------------------TEKSACKSSDLWALG 269
Query: 246 CVIAELFTEGVPLFDLSQLLAYRN----GHFFPEQVLNKIEDHSIRELVTQMIHREPDKR 301
C+I +L P ++ L ++ + FPE+ K R+LV +++ + KR
Sbjct: 270 CIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK-----ARDLVEKLLVLDATKR 324
Query: 302 LEAED 306
L E+
Sbjct: 325 LGCEE 329
>gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent
protein kinase-1 [Homo sapiens]
Length = 471
Score = 47.0 bits (110), Expect = 1e-04
Identities = 42/185 (22%), Positives = 79/185 (42%), Gaps = 42/185 (22%)
Query: 126 RWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNY 185
R+ +I++A++ H G+ H D+K EN+++ + +TDF + K PE A N
Sbjct: 202 RFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK-VLSPESKQARANS 260
Query: 186 FFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAG 245
F T++ Y++PE T ++ D+++ G
Sbjct: 261 FVGTAQ----YVSPELL----------------------------TEKSACKSSDLWALG 288
Query: 246 CVIAELFTEGVPLFDLSQLLAYRN----GHFFPEQVLNKIEDHSIRELVTQMIHREPDKR 301
C+I +L P ++ L ++ + FPE+ K R+LV +++ + KR
Sbjct: 289 CIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK-----ARDLVEKLLVLDATKR 343
Query: 302 LEAED 306
L E+
Sbjct: 344 LGCEE 348
>gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo
sapiens]
Length = 396
Score = 47.0 bits (110), Expect = 1e-04
Identities = 42/185 (22%), Positives = 79/185 (42%), Gaps = 42/185 (22%)
Query: 126 RWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNY 185
R+ +I++A++ H G+ H D+K EN+++ + +TDF + K PE A N
Sbjct: 156 RFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK-VLSPESKQARANS 214
Query: 186 FFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAG 245
F T++ Y++PE T ++ D+++ G
Sbjct: 215 FVGTAQ----YVSPELL----------------------------TEKSACKSSDLWALG 242
Query: 246 CVIAELFTEGVPLFDLSQLLAYRN----GHFFPEQVLNKIEDHSIRELVTQMIHREPDKR 301
C+I +L P ++ L ++ + FPE+ K R+LV +++ + KR
Sbjct: 243 CIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK-----ARDLVEKLLVLDATKR 297
Query: 302 LEAED 306
L E+
Sbjct: 298 LGCEE 302
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 47.0 bits (110), Expect = 1e-04
Identities = 67/317 (21%), Positives = 120/317 (37%), Gaps = 51/317 (16%)
Query: 3 NQLAGIAPSQILSVESYFSDIHD-FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPT 61
+++ IA +L ++ + DI +E + LGS F +V A+ R +V + I
Sbjct: 74 SRIPAIALQDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKA 133
Query: 62 LPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLN 121
L E E +R S N + + E S + L+DRI R
Sbjct: 134 LRGKEALVENEIAVLRRISHPNIVALEDVHESPSH-LYLAMELVTGGELFDRIMERGSYT 192
Query: 122 NIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTS---WNWVLLTDFASFKPTYLPED 178
+ + Q+L AV H G+ H D+K EN++ + + ++++DF K
Sbjct: 193 EKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSK------- 245
Query: 179 NPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRA 238
T+ Y+APE Q+ G +A
Sbjct: 246 --IQAGNMLGTACGTPGYVAPELL-------------------------EQKPYG---KA 275
Query: 239 MDIFSAGCVIAELFTEGVPLFD------LSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQ 292
+D+++ G + L P +D SQ+L R + F + I + S ++ +
Sbjct: 276 VDVWALGVISYILLCGYPPFYDESDPELFSQIL--RASYEFDSPFWDDISE-SAKDFIRH 332
Query: 293 MIHREPDKRLEAEDYLK 309
++ R+P KR + L+
Sbjct: 333 LLERDPQKRFTCQQALR 349
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 45.8 bits (107), Expect = 3e-04
Identities = 26/65 (40%), Positives = 37/65 (56%), Gaps = 2/65 (3%)
Query: 109 NLYDRISTRPFLNNIEKR--WIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTD 166
NLYD+I + E+ W FQI++AV HK+G+ H DIKT N+ +T N + L D
Sbjct: 135 NLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGD 194
Query: 167 FASFK 171
+ K
Sbjct: 195 YGLAK 199
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 45.8 bits (107), Expect = 3e-04
Identities = 46/184 (25%), Positives = 79/184 (42%), Gaps = 12/184 (6%)
Query: 23 IHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFA---IQDPTLPLTSYKQELEELKIRLN 79
+ +FE K LG+ + KV + G K++A ++ L + QE + +
Sbjct: 30 VENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVL 89
Query: 80 SAQNCLPFQKASEKASEKAAML--FRQYVRDN-LYDRISTRPFLNNIEKRWIAFQILTAV 136
PF A + A L YV ++ + R + E R +I+ A+
Sbjct: 90 ELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLAL 149
Query: 137 DQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCY 196
+ HK G+ + D+K ENV++ S ++LTDF K +L E+ F++ Y
Sbjct: 150 EHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSK-EFLTEEKERTFSFCGTIE-----Y 203
Query: 197 IAPE 200
+APE
Sbjct: 204 MAPE 207
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 45.8 bits (107), Expect = 3e-04
Identities = 46/184 (25%), Positives = 79/184 (42%), Gaps = 12/184 (6%)
Query: 23 IHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFA---IQDPTLPLTSYKQELEELKIRLN 79
+ +FE K LG+ + KV + G K++A ++ L + QE + +
Sbjct: 30 VENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVL 89
Query: 80 SAQNCLPFQKASEKASEKAAML--FRQYVRDN-LYDRISTRPFLNNIEKRWIAFQILTAV 136
PF A + A L YV ++ + R + E R +I+ A+
Sbjct: 90 ELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLAL 149
Query: 137 DQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCY 196
+ HK G+ + D+K ENV++ S ++LTDF K +L E+ F++ Y
Sbjct: 150 EHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSK-EFLTEEKERTFSFCGTIE-----Y 203
Query: 197 IAPE 200
+APE
Sbjct: 204 MAPE 207
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 45.1 bits (105), Expect = 5e-04
Identities = 67/299 (22%), Positives = 117/299 (39%), Gaps = 48/299 (16%)
Query: 25 DFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPT-LPLTSYKQELEELKIRLNSAQN 83
DF + K +G F KV A+H+ V V +Q L K + E + L + ++
Sbjct: 97 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156
Query: 84 CLPFQKASEKASEKAAMLFRQYVRDNL------YDRISTRPFLNNIEKRWIAFQILTAVD 137
PF + + A L+ +V D + Y R FL R+ A +I +A+
Sbjct: 157 --PFLVGLHFSFQTADKLY--FVLDYINGGELFYHLQRERCFLEP-RARFYAAEIASALG 211
Query: 138 QAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYI 197
H + + D+K EN+++ S ++LTDF K ++ + + F T Y+
Sbjct: 212 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI---EHNSTTSTFCGTPE----YL 264
Query: 198 APERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVP 257
APE + R +D + G V+ E+ P
Sbjct: 265 APEVL----------------------------HKQPYDRTVDWWCLGAVLYEMLYGLPP 296
Query: 258 LFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAF 316
+ + Y N P Q+ I +S R L+ ++ ++ KRL A+D + + + F
Sbjct: 297 FYSRNTAEMYDNILNKPLQLKPNI-TNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVF 354
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 45.1 bits (105), Expect = 5e-04
Identities = 67/299 (22%), Positives = 117/299 (39%), Gaps = 48/299 (16%)
Query: 25 DFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPT-LPLTSYKQELEELKIRLNSAQN 83
DF + K +G F KV A+H+ V V +Q L K + E + L + ++
Sbjct: 111 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 170
Query: 84 CLPFQKASEKASEKAAMLFRQYVRDNL------YDRISTRPFLNNIEKRWIAFQILTAVD 137
PF + + A L+ +V D + Y R FL R+ A +I +A+
Sbjct: 171 --PFLVGLHFSFQTADKLY--FVLDYINGGELFYHLQRERCFLEP-RARFYAAEIASALG 225
Query: 138 QAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYI 197
H + + D+K EN+++ S ++LTDF K ++ + + F T Y+
Sbjct: 226 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI---EHNSTTSTFCGTPE----YL 278
Query: 198 APERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVP 257
APE + R +D + G V+ E+ P
Sbjct: 279 APEVL----------------------------HKQPYDRTVDWWCLGAVLYEMLYGLPP 310
Query: 258 LFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAF 316
+ + Y N P Q+ I +S R L+ ++ ++ KRL A+D + + + F
Sbjct: 311 FYSRNTAEMYDNILNKPLQLKPNI-TNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVF 368
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 45.1 bits (105), Expect = 5e-04
Identities = 67/299 (22%), Positives = 117/299 (39%), Gaps = 48/299 (16%)
Query: 25 DFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPT-LPLTSYKQELEELKIRLNSAQN 83
DF + K +G F KV A+H+ V V +Q L K + E + L + ++
Sbjct: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 184
Query: 84 CLPFQKASEKASEKAAMLFRQYVRDNL------YDRISTRPFLNNIEKRWIAFQILTAVD 137
PF + + A L+ +V D + Y R FL R+ A +I +A+
Sbjct: 185 --PFLVGLHFSFQTADKLY--FVLDYINGGELFYHLQRERCFLEP-RARFYAAEIASALG 239
Query: 138 QAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYI 197
H + + D+K EN+++ S ++LTDF K ++ + + F T Y+
Sbjct: 240 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI---EHNSTTSTFCGTPE----YL 292
Query: 198 APERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVP 257
APE + R +D + G V+ E+ P
Sbjct: 293 APEVL----------------------------HKQPYDRTVDWWCLGAVLYEMLYGLPP 324
Query: 258 LFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAF 316
+ + Y N P Q+ I +S R L+ ++ ++ KRL A+D + + + F
Sbjct: 325 FYSRNTAEMYDNILNKPLQLKPNI-TNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVF 382
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 45.1 bits (105), Expect = 5e-04
Identities = 67/299 (22%), Positives = 117/299 (39%), Gaps = 48/299 (16%)
Query: 25 DFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPT-LPLTSYKQELEELKIRLNSAQN 83
DF + K +G F KV A+H+ V V +Q L K + E + L + ++
Sbjct: 192 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 251
Query: 84 CLPFQKASEKASEKAAMLFRQYVRDNL------YDRISTRPFLNNIEKRWIAFQILTAVD 137
PF + + A L+ +V D + Y R FL R+ A +I +A+
Sbjct: 252 --PFLVGLHFSFQTADKLY--FVLDYINGGELFYHLQRERCFLEP-RARFYAAEIASALG 306
Query: 138 QAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYI 197
H + + D+K EN+++ S ++LTDF K ++ + + F T Y+
Sbjct: 307 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI---EHNSTTSTFCGTPE----YL 359
Query: 198 APERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVP 257
APE + R +D + G V+ E+ P
Sbjct: 360 APEVL----------------------------HKQPYDRTVDWWCLGAVLYEMLYGLPP 391
Query: 258 LFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAF 316
+ + Y N P Q+ I +S R L+ ++ ++ KRL A+D + + + F
Sbjct: 392 FYSRNTAEMYDNILNKPLQLKPNI-TNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVF 449
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 45.1 bits (105), Expect = 5e-04
Identities = 50/200 (25%), Positives = 78/200 (39%), Gaps = 42/200 (21%)
Query: 110 LYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFAS 169
L+D I + +E R + QIL+AVD H+ V H D+K ENV++ + + DF
Sbjct: 101 LFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL 160
Query: 170 FKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQ 229
N F TS Y APE + G ++A
Sbjct: 161 --------SNMMSDGEFLRTSCGSPNYAAPE-VISGRLYAGP------------------ 193
Query: 230 RTRGELKRAMDIFSAGCVIAELFTEGVPLFD---LSQLLAYRNGHFFPEQVLNKIEDHSI 286
+DI+S G ++ L +P D + R G F+ + LN+ S+
Sbjct: 194 --------EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNR----SV 241
Query: 287 RELVTQMIHREPDKRLEAED 306
L+ M+ +P KR +D
Sbjct: 242 ATLLMHMLQVDPLKRATIKD 261
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 44.7 bits (104), Expect = 6e-04
Identities = 32/144 (22%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Query: 26 FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKI-RLNSAQNC 84
++ +++LG F V A+HR V + I L ++ ++ E+++ +L + +
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHI 86
Query: 85 LPFQKASEKASEKAAMLFRQYVRDN-LYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSG 143
+ + E ++ + ++ ++ ++D +++ L+ E R +QIL+AV+ H
Sbjct: 87 IKLYQVME--TKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHH 144
Query: 144 VRHGDIKTENVMVTSWNWVLLTDF 167
+ H D+KTEN+++ + L DF
Sbjct: 145 IVHRDLKTENLLLDGNMDIKLADF 168
>gi|169234742 NACHT and WD repeat domain containing 1 [Homo sapiens]
Length = 1429
Score = 44.3 bits (103), Expect = 8e-04
Identities = 35/144 (24%), Positives = 60/144 (41%), Gaps = 13/144 (9%)
Query: 1144 ITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIA- 1202
IT+ A + + L IGT G MA WDM Q I H + ++ +A
Sbjct: 736 ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVI----HMLTGHTGEVRCVKIFAKGTLAN 791
Query: 1203 AVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSD 1262
+ + + +W++ +G +FT+W + +E Q I+ D ++ + S
Sbjct: 792 SASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQ--------IWNLHVDEAHKVVYSASG 843
Query: 1263 MKIRFWDLAYPERSYVVAGSTSSP 1286
KI W+L E + + G S P
Sbjct: 844 SKINAWNLETAEPVFHILGDASDP 867
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 44.3 bits (103), Expect = 8e-04
Identities = 61/307 (19%), Positives = 115/307 (37%), Gaps = 50/307 (16%)
Query: 970 WESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIWNSQKMEGKT 1029
W KP +R G HK V ++ S +L A+ S D TV++W K GK
Sbjct: 45 WNFKPHARAYRYVG--------HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDK-RGKF 95
Query: 1030 TTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRI 1089
+ + V+++ F +LA AS++ ++++ + + S H R
Sbjct: 96 S------EFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRC 149
Query: 1090 LDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAV 1149
DG ++ + + ++ WD ++N + + S +F V
Sbjct: 150 AKFSPDG-------------RLIVSCSEDKTIKIWD---TTNKQCVNNFSDSVGFANF-V 192
Query: 1150 DIHQCWLCIGT--SSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGN 1207
D + CI + S T+ WD+R + H + +S HP + A+ G
Sbjct: 193 DFNPSGTCIASAGSDQTVKVWDVRVN-KLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
Query: 1208 NEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRF 1267
+ + D+ G +TL + P + S + G + + G+D ++
Sbjct: 252 --LKILDLLEGRLIYTLQGHTGPVFT-------------VSFSKGGELFASGGADTQVLL 296
Query: 1268 WDLAYPE 1274
W + E
Sbjct: 297 WRTNFDE 303
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 43.9 bits (102), Expect = 0.001
Identities = 32/150 (21%), Positives = 62/150 (41%), Gaps = 1/150 (0%)
Query: 23 IHDFEYDKSLGSTRFFKVARAKHR-EGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSA 81
++DF+Y K LG F KV + + G ++ + L E ++ N+
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR 204
Query: 82 QNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHK 141
L K S + ++ + L+ +S + R+ +I++A+D H
Sbjct: 205 HPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS 264
Query: 142 SGVRHGDIKTENVMVTSWNWVLLTDFASFK 171
+ + D+K EN+M+ + +TDF K
Sbjct: 265 GKIVYRDLKLENLMLDKDGHIKITDFGLCK 294
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 43.9 bits (102), Expect = 0.001
Identities = 32/150 (21%), Positives = 62/150 (41%), Gaps = 1/150 (0%)
Query: 23 IHDFEYDKSLGSTRFFKVARAKHR-EGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSA 81
++DF+Y K LG F KV + + G ++ + L E ++ N+
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR 204
Query: 82 QNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHK 141
L K S + ++ + L+ +S + R+ +I++A+D H
Sbjct: 205 HPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS 264
Query: 142 SGVRHGDIKTENVMVTSWNWVLLTDFASFK 171
+ + D+K EN+M+ + +TDF K
Sbjct: 265 GKIVYRDLKLENLMLDKDGHIKITDFGLCK 294
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 43.9 bits (102), Expect = 0.001
Identities = 50/200 (25%), Positives = 78/200 (39%), Gaps = 42/200 (21%)
Query: 110 LYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFAS 169
L+D I L+ E R + QIL+ VD H+ V H D+K ENV++ + + DF
Sbjct: 112 LFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL 171
Query: 170 FKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQ 229
N F TS Y APE + G ++A
Sbjct: 172 --------SNMMSDGEFLRTSCGSPNYAAPE-VISGRLYAGP------------------ 204
Query: 230 RTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYR---NGHFFPEQVLNKIEDHSI 286
+DI+S+G ++ L +P D ++ +G F+ Q LN S+
Sbjct: 205 --------EVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNP----SV 252
Query: 287 RELVTQMIHREPDKRLEAED 306
L+ M+ +P KR +D
Sbjct: 253 ISLLKHMLQVDPMKRATIKD 272
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 43.9 bits (102), Expect = 0.001
Identities = 64/283 (22%), Positives = 114/283 (40%), Gaps = 48/283 (16%)
Query: 26 FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKI-RLNSAQNC 84
++ + +LG F V +HR V + I L + ++ E++I ++ +
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI 79
Query: 85 LPFQKASEKASEKAAMLFRQYVRDN-LYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSG 143
+ + E S L +Y ++ ++D ++ LN E R +QIL+AVD H
Sbjct: 80 IKLYQVMETKS--MLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRK 137
Query: 144 VRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFV 203
+ H D+K EN+++ + + + DF F FF +
Sbjct: 138 IVHRDLKAENLLLDNNMNIKIADFG--------------FGNFFKS-------------- 169
Query: 204 DGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQ 263
G + AT + P ++ Q+ G +DI+S G V+ L +P FD
Sbjct: 170 -GELLAT---WCGSPPYAAPEVFEGQQYEGP---QLDIWSMGVVLYVLVCGALP-FDGPT 221
Query: 264 LLAYR----NGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRL 302
L R G F +++ +H IR +M+ +P KRL
Sbjct: 222 LPILRQRVLEGRFRIPYFMSEDCEHLIR----RMLVLDPSKRL 260
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,256,309
Number of Sequences: 37866
Number of extensions: 2294737
Number of successful extensions: 9069
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 205
Number of HSP's successfully gapped in prelim test: 240
Number of HSP's that attempted gapping in prelim test: 8066
Number of HSP's gapped (non-prelim): 1212
length of query: 1358
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1243
effective length of database: 13,892,928
effective search space: 17268909504
effective search space used: 17268909504
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.