Search of human proteins with 238814326

Search of human proteins with 238814326

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
         (555 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|238814326 solute carrier family 22, member 20 [Homo sapiens]      1107   0.0  
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   503   e-142
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   501   e-142
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          488   e-138
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   457   e-129
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   457   e-129
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          419   e-117
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          412   e-115
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]       395   e-110
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]       362   e-100
gi|153791484 putative UST1-like organic anion transporter [Homo ...   355   6e-98
gi|166064021 solute carrier family 22 (organic anion transporter...   348   7e-96
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   347   2e-95
gi|42542386 solute carrier family 22 (organic anion/cation trans...   343   2e-94
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   342   5e-94
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          259   4e-69
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           241   1e-63
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          231   1e-60
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           228   9e-60
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   220   2e-57
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        219   4e-57
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          219   7e-57
gi|157426885 organic cation transporter like 4 [Homo sapiens]         214   2e-55
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       206   3e-53
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   193   3e-49
gi|24308167 SV2 related protein [Homo sapiens]                        129   5e-30
gi|170650643 solute carrier family 22, member 23 isoform a [Homo...   127   3e-29
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   112   9e-25
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...   111   2e-24
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6...   109   8e-24

>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score = 1107 bits (2863), Expect = 0.0
 Identities = 555/555 (100%), Positives = 555/555 (100%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST 60
           MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST
Sbjct: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST 60

Query: 61  NDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAATEGCKDGWVYNRSVFPS 120
           NDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAATEGCKDGWVYNRSVFPS
Sbjct: 61  NDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAATEGCKDGWVYNRSVFPS 120

Query: 121 TIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAA 180
           TIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAA
Sbjct: 121 TIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAA 180

Query: 181 TAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILA 240
           TAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILA
Sbjct: 181 TAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILA 240

Query: 241 GVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRK 300
           GVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRK
Sbjct: 241 GVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRK 300

Query: 301 EEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLAM 360
           EEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLAM
Sbjct: 301 EEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLAM 360

Query: 361 DLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVPEG 420
           DLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVPEG
Sbjct: 361 DLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVPEG 420

Query: 421 TQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLVTTL 480
           TQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLVTTL
Sbjct: 421 TQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLVTTL 480

Query: 481 GEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGSSKKHVEEKSEE 540
           GEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGSSKKHVEEKSEE
Sbjct: 481 GEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGSSKKHVEEKSEE 540

Query: 541 ISLQQLRASPLKETI 555
           ISLQQLRASPLKETI
Sbjct: 541 ISLQQLRASPLKETI 555


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  503 bits (1294), Expect = e-142
 Identities = 256/546 (46%), Positives = 344/546 (63%), Gaps = 7/546 (1%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST 60
           MAF DLL  +G +GRFQ     L++LP  L+A HN LQNFTAA+P HHCR PA+   +  
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60

Query: 61  NDSGAWLRATIPLDQLGAPEPCRRFTKPQWAL--LSPNSSIPGAATEGCKDGWVYNRSVF 118
                WL    P D+ G PE C RFT PQW L  L+   +    ATE C DGW+Y+ S F
Sbjct: 61  GGLEVWL----PRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTF 116

Query: 119 PSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASG 178
           PSTIV EWDLVC  R LR LAQS+YM GVL+GA VFG LADRLG +  L+ +YLQ A SG
Sbjct: 117 PSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSG 176

Query: 179 AATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLI 238
              A+  +F  YC FR L GM  +GI LN ++L VEWMP   R   G L+GY ++LGQ +
Sbjct: 177 TCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFL 236

Query: 239 LAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNG 298
           LAGVAY +  WR LQ  +SAPF  FF+YSW+  ES+RW    G+  L ++ LQ+VA +NG
Sbjct: 237 LAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARING 296

Query: 299 RKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGL 358
           ++EEG +L+ EV+ + +Q E        S ++L R P +R +  CL ++WF+ S AYYGL
Sbjct: 297 KREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGL 356

Query: 359 AMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVP 418
            MDLQ FG+S+YL+Q +FG ++ PA LV    +  +GRR    + L+LAG+ ++ N  +P
Sbjct: 357 VMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIP 416

Query: 419 EGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLVT 478
           +   I+ T+ A LGKGCLA+SF C++L+TGELYPT IRQ GMG  S  AR+G + +PLV+
Sbjct: 417 QDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVS 476

Query: 479 TLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGSSKKHVEEKS 538
              E    +P   +GA  + A     +L ET   PL +T+  +E R K   +++  E + 
Sbjct: 477 MTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESR-KGKQTRQQQEHQK 535

Query: 539 EEISLQ 544
             + LQ
Sbjct: 536 YMVPLQ 541


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  501 bits (1290), Expect = e-142
 Identities = 252/526 (47%), Positives = 335/526 (63%), Gaps = 6/526 (1%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST 60
           MAF DLL  +G +GRFQ     L++LP  L+A HN LQNFTAA+P HHCR PA+   +  
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60

Query: 61  NDSGAWLRATIPLDQLGAPEPCRRFTKPQWAL--LSPNSSIPGAATEGCKDGWVYNRSVF 118
                WL    P D+ G PE C RFT PQW L  L+   +    ATE C DGW+Y+ S F
Sbjct: 61  GGLEVWL----PRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTF 116

Query: 119 PSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASG 178
           PSTIV EWDLVC  R LR LAQS+YM GVL+GA VFG LADRLG +  L+ +YLQ A SG
Sbjct: 117 PSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSG 176

Query: 179 AATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLI 238
              A+  +F  YC FR L GM  +GI LN ++L VEWMP   R   G L+GY ++LGQ +
Sbjct: 177 TCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFL 236

Query: 239 LAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNG 298
           LAGVAY +  WR LQ  +SAPF  FF+YSW+  ES+RW    G+  L ++ LQ+VA +NG
Sbjct: 237 LAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARING 296

Query: 299 RKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGL 358
           ++EEG +L+ EV+ + +Q E        S ++L R P +R +  CL ++WF+ S AYYGL
Sbjct: 297 KREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGL 356

Query: 359 AMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVP 418
            MDLQ FG+S+YL+Q +FG ++ PA LV    +  +GRR    + L+LAG+ ++ N  +P
Sbjct: 357 VMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIP 416

Query: 419 EGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLVT 478
           +   I+ T+ A LGKGCLA+SF C++L+TGELYPT IRQ GMG  S  AR+G + +PLV+
Sbjct: 417 QDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVS 476

Query: 479 TLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERR 524
              E    +P   +GA  + A     +L ET   PL +T+  +E R
Sbjct: 477 MTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESR 522


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  488 bits (1255), Expect = e-138
 Identities = 258/550 (46%), Positives = 346/550 (62%), Gaps = 23/550 (4%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST 60
           M F+++LD +GSMG FQ  H A+L LP   +A HN LQ FTAA P HHCR P N   AST
Sbjct: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHN---AST 57

Query: 61  NDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPG---AATEGCKDGWVYNRSV 117
              G W+   +P+   G PE C RF  P      PN+S+P     A E C DGWVYN + 
Sbjct: 58  ---GPWV---LPMGPNGKPERCLRFVHP------PNASLPNDTQRAMEPCLDGWVYNST- 104

Query: 118 FPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAAS 177
              +IV EWDLVC +  L+++AQS++MAG+L+G  V G L+DR G +  L  SYL LAAS
Sbjct: 105 -KDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAAS 163

Query: 178 GAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQL 237
           G+  A+  +F  Y VFRFL G   SGI L++V L VEW+PTR R +    LGY +T GQ 
Sbjct: 164 GSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQF 223

Query: 238 ILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMN 297
           IL G+AY I  WR LQ  +S PF +FFL SWW PES RWL+L GKS  A++ L++VA  N
Sbjct: 224 ILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFN 283

Query: 298 GRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYG 357
           G+KEEGERL+ E +   +Q E +      +  DLFR P +R++T CL + WF+   AYY 
Sbjct: 284 GKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYS 343

Query: 358 LAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFV 417
           LAM +++FG++LY++Q +FG ++ PA  +   ++ Y+GR  T A+ L+LAG  ++A  FV
Sbjct: 344 LAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFV 403

Query: 418 PEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLV 477
           P   Q + T  A  GKGCL+SSF C++L+T ELYPT IRQ GMG +++  R+G + +PLV
Sbjct: 404 PLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLV 463

Query: 478 TTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMER---RVKEGSSKKHV 534
              GE    +P + +G TA+L G A   L ET N PL ETI  +E    R K+   +  V
Sbjct: 464 KITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEV 523

Query: 535 EEKSEEISLQ 544
           E+ S+ I LQ
Sbjct: 524 EKASQRIPLQ 533


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  457 bits (1177), Expect = e-129
 Identities = 228/458 (49%), Positives = 300/458 (65%), Gaps = 6/458 (1%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST 60
           MAF DLL  +G +GRFQ     L++LP  L+A HN LQNFTAA+P HHCR PA+   +  
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60

Query: 61  NDSGAWLRATIPLDQLGAPEPCRRFTKPQWAL--LSPNSSIPGAATEGCKDGWVYNRSVF 118
                WL    P D+ G PE C RFT PQW L  L+   +    ATE C DGW+Y+ S F
Sbjct: 61  GGLEVWL----PRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTF 116

Query: 119 PSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASG 178
           PSTIV EWDLVC  R LR LAQS+YM GVL+GA VFG LADRLG +  L+ +YLQ A SG
Sbjct: 117 PSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSG 176

Query: 179 AATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLI 238
              A+  +F  YC FR L GM  +GI LN ++L VEWMP   R   G L+GY ++LGQ +
Sbjct: 177 TCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFL 236

Query: 239 LAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNG 298
           LAGVAY +  WR LQ  +SAPF  FF+YSW+  ES+RW    G+  L ++ LQ+VA +NG
Sbjct: 237 LAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARING 296

Query: 299 RKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGL 358
           ++EEG +L+ EV+ + +Q E        S ++L R P +R +  CL ++WF+ S AYYGL
Sbjct: 297 KREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGL 356

Query: 359 AMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVP 418
            MDLQ FG+S+YL+Q +FG ++ PA LV    +  +GRR    + L+LAG+ ++ N  +P
Sbjct: 357 VMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIP 416

Query: 419 EGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIR 456
           +   I+ T+ A LGKGCLA+SF C++L+TGELYPT IR
Sbjct: 417 QDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR 454


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  457 bits (1177), Expect = e-129
 Identities = 228/458 (49%), Positives = 300/458 (65%), Gaps = 6/458 (1%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST 60
           MAF DLL  +G +GRFQ     L++LP  L+A HN LQNFTAA+P HHCR PA+   +  
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN 60

Query: 61  NDSGAWLRATIPLDQLGAPEPCRRFTKPQWAL--LSPNSSIPGAATEGCKDGWVYNRSVF 118
                WL    P D+ G PE C RFT PQW L  L+   +    ATE C DGW+Y+ S F
Sbjct: 61  GGLEVWL----PRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTF 116

Query: 119 PSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASG 178
           PSTIV EWDLVC  R LR LAQS+YM GVL+GA VFG LADRLG +  L+ +YLQ A SG
Sbjct: 117 PSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSG 176

Query: 179 AATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLI 238
              A+  +F  YC FR L GM  +GI LN ++L VEWMP   R   G L+GY ++LGQ +
Sbjct: 177 TCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFL 236

Query: 239 LAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNG 298
           LAGVAY +  WR LQ  +SAPF  FF+YSW+  ES+RW    G+  L ++ LQ+VA +NG
Sbjct: 237 LAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARING 296

Query: 299 RKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGL 358
           ++EEG +L+ EV+ + +Q E        S ++L R P +R +  CL ++WF+ S AYYGL
Sbjct: 297 KREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGL 356

Query: 359 AMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVP 418
            MDLQ FG+S+YL+Q +FG ++ PA LV    +  +GRR    + L+LAG+ ++ N  +P
Sbjct: 357 VMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIP 416

Query: 419 EGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIR 456
           +   I+ T+ A LGKGCLA+SF C++L+TGELYPT IR
Sbjct: 417 QDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR 454


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  419 bits (1078), Expect = e-117
 Identities = 215/533 (40%), Positives = 325/533 (60%), Gaps = 9/533 (1%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPA-NHTEAS 59
           MAF++LLD +G +GRFQ+  T  L++    L   + L+NF+AAVP H C  P  +++ A 
Sbjct: 1   MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60

Query: 60  TNDSG-----AWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPG---AATEGCKDGW 111
            +  G     A L  +IP      P  CRRF +PQW LL PN++      A TE C DGW
Sbjct: 61  ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120

Query: 112 VYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSY 171
           VY+RS+F STIV +W+LVC++  L+ +AQS+Y+AG+LVGAA  G  +DR G +  L WSY
Sbjct: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180

Query: 172 LQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYS 231
           LQ+A  G A A+  +F  YC+FRFL+    +G+++N+ +L++EW   R R +   L    
Sbjct: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240

Query: 232 FTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQ 291
           F+ G  + A VAY +R W  LQ  +S PF + FLYSWWL ES+RWLL  G+    +Q L 
Sbjct: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300

Query: 292 KVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSN 351
           +VAA+NG+    + LT EV+ S ++ E +      S+  L R P +R  TC   + WF+ 
Sbjct: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360

Query: 352 SVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMV 411
              ++GLA+DLQ  G +++L+Q   G+++ PA + A   + ++GRR T+A+ L+LAGL +
Sbjct: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420

Query: 412 IANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGG 471
           +AN  VP     L +A A LG G + ++F C+ +++ EL+PT +R   +G   + AR G 
Sbjct: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480

Query: 472 LTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERR 524
           +  PLV  LG +   LP + +G   +L+GLA  +L ET+++PL +TI  ++ +
Sbjct: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQ 533


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  412 bits (1058), Expect = e-115
 Identities = 220/529 (41%), Positives = 313/529 (59%), Gaps = 8/529 (1%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPA--NHTEA 58
           MAF+ LL+  G +G FQ       +LPC ++     L+NF+AA+P H C      N +  
Sbjct: 1   MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAV 60

Query: 59  STNDSG-AWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPG---AATEGCKDGWVYN 114
           STN +  A L  +IP      P  CRRF +PQW LL PN++      A TE C DGWVY+
Sbjct: 61  STNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYD 120

Query: 115 RSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQL 174
           RSVF STIV +WDLVC ++ L+ L+QS++M+G+LVG+ ++G L+ R G K  L W  LQL
Sbjct: 121 RSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQL 180

Query: 175 AASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTL 234
           A +G +T +  +F  YC  RF+     +GI L+S++L+VEW  T  R V   ++G +F+ 
Sbjct: 181 AVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSA 240

Query: 235 GQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVA 294
           GQ  L G+A+ +R WR LQ A S PF    L SWWLPES+RWL++ GK   A+Q L+KVA
Sbjct: 241 GQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVA 300

Query: 295 AMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVA 354
            +NG K E + LT EV+ S ++ E AS     S+LDLF  P +R  +C ++V+ FS  ++
Sbjct: 301 RINGHK-EAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLIS 359

Query: 355 YYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIAN 414
           YYGL  DLQ  G  ++L+QALFG ++          + ++GRR   A    +AGL ++AN
Sbjct: 360 YYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILAN 419

Query: 415 MFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTA 474
           M VP+  Q L    A LGKGC   S  C+ ++  EL+PT +R    G      RLG +  
Sbjct: 420 MLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMG 479

Query: 475 PLVTTLGEYSTILPPVSFGATAILAGLAVC-VLTETRNMPLVETIAAME 522
           PL+    +   +LPP+ +G  +I + L V   L ET+ +PL +TI  +E
Sbjct: 480 PLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLE 528


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score =  395 bits (1014), Expect = e-110
 Identities = 219/549 (39%), Positives = 318/549 (57%), Gaps = 19/549 (3%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHC--------RGP 52
           MAF +LL  +G +GRFQ+ H   +L    LL  H  L+NF AA+P H C         G 
Sbjct: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60

Query: 53  ANHTEASTNDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPG---AATEGCKD 109
            N T   + D  A LR +IPLD    PE CRRF  PQW LL  N +I     A TE C D
Sbjct: 61  GNETGILSED--ALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVD 118

Query: 110 GWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVW 169
           GWVY++S FPSTIV +WDLVC+ ++L+ + Q + + G+LVG  + G ++DR G +  L W
Sbjct: 119 GWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRW 178

Query: 170 SYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLG 229
             LQLA +    A+  +F  YCV RFL G +   II N+   + EW+    + +  IL  
Sbjct: 179 CLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSS 238

Query: 230 YSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQN 289
            + ++GQ+IL G+AY+ R W+ L    S PF +FFL S WL ES+RWL++  K    ++ 
Sbjct: 239 GALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKA 298

Query: 290 LQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWF 349
           L+KVA  NG K   E L  EV+ S +Q E  +  T  ++ DLFR P++RK  C L+ + F
Sbjct: 299 LRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRF 358

Query: 350 SNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGL 409
           +N++ +YG  ++LQ  G +++L+Q L+G +      +A  T+ ++GRR +   F+ L GL
Sbjct: 359 ANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGL 418

Query: 410 MVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARL 469
            ++AN FVP+  Q L  A A LG GC A++F  V +   EL PT +R    G     +R+
Sbjct: 419 SILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRI 478

Query: 470 GGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGS 529
           G   APL+ TL  + T LP + +G   I+ GL V +L ET+N+PL +TI  +E      +
Sbjct: 479 GAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVE------N 532

Query: 530 SKKHVEEKS 538
            KK+++EK+
Sbjct: 533 QKKNLKEKA 541


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score =  362 bits (930), Expect = e-100
 Identities = 206/531 (38%), Positives = 305/531 (57%), Gaps = 9/531 (1%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPA-NHTEAS 59
           M F  LLD +G MGRFQ+   A   +   LL  +  L+NFTA  P H C  P  ++   S
Sbjct: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60

Query: 60  TNDSGAW-----LRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAA---TEGCKDGW 111
            ND+G       LR +IPLD    P+ C+RF  PQW LL  N + P      TE C DGW
Sbjct: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120

Query: 112 VYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSY 171
           VY+RS F STIV EWDLVCE+++L+ + QS++MAG L+G  ++G L+DR+G K      +
Sbjct: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180

Query: 172 LQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYS 231
           LQLA S    A+  +F  YC+ RFL G +   I+ N+  L +EW   R R++  ++L  S
Sbjct: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240

Query: 232 FTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQ 291
           +++GQ++L G+A+ I+ W  LQ  +S P ++ FL SW + ES+RWL+++ +    ++ L+
Sbjct: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300

Query: 292 KVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSN 351
           +VA +NG+K   E LT E++ S ++ E  +V    SI  LFR P +R     L  + F+ 
Sbjct: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360

Query: 352 SVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMV 411
           +V +YGL ++LQ  G ++ L Q L G +   A  V+  T+ ++GRR +   F    GL +
Sbjct: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420

Query: 412 IANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGG 471
           + N F+P+  QIL    A LG G ++++     +   EL PT +R    G  +V  R G 
Sbjct: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480

Query: 472 LTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAME 522
             APL+ TL  YS  LP +S+G   ILA   + +L ETR++PL  TI  +E
Sbjct: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVE 531


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  355 bits (911), Expect = 6e-98
 Identities = 200/531 (37%), Positives = 296/531 (55%), Gaps = 9/531 (1%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHC------RGPAN 54
           MAF DLLD +G +GRFQ+     L++   ++     L+NF A +  H C           
Sbjct: 1   MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60

Query: 55  HTEASTNDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAA---TEGCKDGW 111
             +  T    A LR +IP D    PE CRRF  PQW L+  N + P  +   TE C DGW
Sbjct: 61  DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120

Query: 112 VYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSY 171
           VY++S FPSTIV +WDLVCE++ L  +A+ ++MAG++VG  ++G L+DR G K  L WSY
Sbjct: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180

Query: 172 LQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYS 231
           LQLA  G   A+  +   YC  RFL G     II+N+V L+VEW+  +   +A  L   +
Sbjct: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240

Query: 232 FTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQ 291
            ++G + L  +A++IR    LQ  +SAP  +FFL+S WL ES+RWL+++ K +  ++ L+
Sbjct: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300

Query: 292 KVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSN 351
           K A  NG K   + LT EV+ S ++ E  +    +S+ +L R P I K  C L  + F++
Sbjct: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360

Query: 352 SVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMV 411
           ++ ++GL + LQ  G +++L+Q LFG +   A  VA   + ++ RR +    + L    +
Sbjct: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420

Query: 412 IANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGG 471
           +A +FVP+  Q L    A LG G  +    C      EL P+ IR    G     A +GG
Sbjct: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480

Query: 472 LTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAME 522
             A L+  L  YS  LP + +G  AIL+GL V +L ETRN PL+++I  +E
Sbjct: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVE 531


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  348 bits (893), Expect = 7e-96
 Identities = 201/539 (37%), Positives = 291/539 (53%), Gaps = 10/539 (1%)

Query: 3   FTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEASTND 62
           F  +L  +G  GRFQ+    LL +   L   + F   F     PHHC             
Sbjct: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLS 63

Query: 63  SGAWLRATIPLDQLGAPEPCRRFTKPQW-ALLSPNSSIPGAATEGCKDGWVYNRSVFPST 121
           +   L  ++PLD  G PEPC  F  P   A L    S     T+ C  GW Y  +  PS 
Sbjct: 64  AAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPS- 122

Query: 122 IVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAAT 181
           +  E++LVC+ + L+D  QSV+MAG+LVG  +FG L DR+G K  ++   L     G AT
Sbjct: 123 LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLAT 182

Query: 182 AYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILAG 241
           A+  SF  Y   RF +    +G+  ++V+L+ EW+    RT A +L   +F+LGQ++LAG
Sbjct: 183 AFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAG 242

Query: 242 VAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRKE 301
           +AY  R WR LQ   +AP L+ F Y W LPES+RWLL  G+   A+Q +QK A++N RK 
Sbjct: 243 LAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRK- 301

Query: 302 EGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLAMD 361
               L+ E+M+  +  +      S + LDLFR P +RKVT  +  +WF +S+ YYGL++ 
Sbjct: 302 ----LSPELMNQLVPEKTGP---SGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQ 354

Query: 362 LQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVPEGT 421
           +  FGL +YL Q +FG +  PA   +   M   GR+ +    L+L GLM I  +F+P   
Sbjct: 355 VGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADL 414

Query: 422 QILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLVTTLG 481
            ++ T  A +GK   A++F   Y+++ EL+PT +RQ GMG   + +R+GG+  PLV  LG
Sbjct: 415 PVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLG 474

Query: 482 EYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGSSKKHVEEKSEE 540
           EY   LP + +G+  I+AGL   +L ET    L +T+  +E      S K    EK  E
Sbjct: 475 EYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETE 533


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  347 bits (890), Expect = 2e-95
 Identities = 211/558 (37%), Positives = 294/558 (52%), Gaps = 24/558 (4%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST 60
           M F +LL+ +G  G FQL + ALL LP  LL  H  L  F AAVP H C  P      S 
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60

Query: 61  NDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSI-----------PGAATEGCKD 109
            D   WL A +P +  G    C RF  PQ     PN+++              AT  C  
Sbjct: 61  QD--VWLEAHLPREPDGTLSSCLRFAYPQ---ALPNTTLGEERQSRGELEDEPATVPCSQ 115

Query: 110 GWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVW 169
           GW Y+ S F STI  EWDLVCE + L   A + + AGVLVGA  FG L+DR G +  L+ 
Sbjct: 116 GWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLV 175

Query: 170 SYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLG 229
           +Y+     G A+A   S+  + + R L G   +G  +  + L +EW+    RTVAG+L  
Sbjct: 176 AYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSS 235

Query: 230 YSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQN 289
             +T G ++LA V YLIR WR L  A++ P     L  WW+PES+RWLL  G  + A + 
Sbjct: 236 TFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRY 295

Query: 290 LQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWF 349
           L   A +NGR    +  ++E +S     E   V    S LDLFRTP +R ++ C +V+WF
Sbjct: 296 LLHCARLNGRPVCEDSFSQEAVSKVAAGE--RVVRRPSYLDLFRTPRLRHISLCCVVVWF 353

Query: 350 SNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGL 409
             + +YYGL++D+   GL++Y  Q LFG +  P+ L+   ++ Y GRR T A  L+   L
Sbjct: 354 GVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTAL 413

Query: 410 MVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARL 469
                + V    +   T  A +GK    ++F   YLFT ELYPT +RQ GMG  ++  RL
Sbjct: 414 AFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRL 473

Query: 470 GGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGS 529
           GG  APL   L      LP +++G  A+LA     +L ETR   L ETI  +ER+    S
Sbjct: 474 GGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERK----S 529

Query: 530 SKKHVEEKSEEISLQQLR 547
           +   ++E  EE+ ++Q++
Sbjct: 530 APTSLQE--EEMPMKQVQ 545


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score =  343 bits (880), Expect = 2e-94
 Identities = 205/550 (37%), Positives = 298/550 (54%), Gaps = 12/550 (2%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPA-NHTEAS 59
           MAF DLL   G + RFQ+  T  L +       H  L+NFTA +P H C     ++   S
Sbjct: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60

Query: 60  TNDSGAW-----LRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPG---AATEGCKDGW 111
            ND+GA      LR +IPLD    PE CRRF  PQW LL  N + P    A  E C DGW
Sbjct: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120

Query: 112 VYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSY 171
           VY+R  F STIV EWDLVC++++L  +A+ V+MAG++VG  + G L+DR G +  L W Y
Sbjct: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180

Query: 172 LQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYS 231
           LQ+A  G   A   +F  YC  RFL G+    +I N++ L+ EW   R + + GI LG  
Sbjct: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAM-GITLGMC 239

Query: 232 FT-LGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNL 290
            + +  + LAG+A+ IR W  LQ  +S P+ + FL S WL ES+RWL+++ K +  ++ L
Sbjct: 240 PSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299

Query: 291 QKVAAMNGRKEEGERLTKEVMSSYIQSEF-ASVCTSNSILDLFRTPAIRKVTCCLMVIWF 349
           +K A  +G K   + LT E++ S ++ E  A+     S+ ++   P I K    L    F
Sbjct: 300 RKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRF 359

Query: 350 SNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGL 409
           +N +AY+GL + +Q  G +++L+Q LFG +   A  VA   + Y+ RRA+    + L  +
Sbjct: 360 ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAI 419

Query: 410 MVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARL 469
            ++A +FVP+  Q L    A LG G  A +    +    E+ PT IR   MG  +  A +
Sbjct: 420 CLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANI 479

Query: 470 GGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGS 529
            G  APL+  L  YS  LP + +G    ++G A  +L ETRN PL +TI   +   K+  
Sbjct: 480 AGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPR 539

Query: 530 SKKHVEEKSE 539
             K  + + E
Sbjct: 540 EPKQEDPRVE 549


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  342 bits (877), Expect = 5e-94
 Identities = 211/560 (37%), Positives = 294/560 (52%), Gaps = 26/560 (4%)

Query: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST 60
           M F +LL+ +G  G FQL + ALL LP  LL  H  L  F AAVP H C  P      S 
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60

Query: 61  NDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSI-----------PGAATEGCKD 109
            D   WL A +P +  G    C RF  PQ     PN+++              AT  C  
Sbjct: 61  QD--VWLEAHLPREPDGTLSSCLRFAYPQ---ALPNTTLGEERQSRGELEDEPATVPCSQ 115

Query: 110 GWVYNRSVFPSTIVME--WDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPL 167
           GW Y+ S F STI  E  WDLVCE + L   A + + AGVLVGA  FG L+DR G +  L
Sbjct: 116 GWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLL 175

Query: 168 VWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGIL 227
           + +Y+     G A+A   S+  + + R L G   +G  +  + L +EW+    RTVAG+L
Sbjct: 176 LVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVL 235

Query: 228 LGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAV 287
               +T G ++LA V YLIR WR L  A++ P     L  WW+PES+RWLL  G  + A 
Sbjct: 236 SSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAH 295

Query: 288 QNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVI 347
           + L   A +NGR    +  ++E +S     E   V    S LDLFRTP +R ++ C +V+
Sbjct: 296 RYLLHCARLNGRPVCEDSFSQEAVSKVAAGE--RVVRRPSYLDLFRTPRLRHISLCCVVV 353

Query: 348 WFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILA 407
           WF  + +YYGL++D+   GL++Y  Q LFG +  P+ L+   ++ Y GRR T A  L+  
Sbjct: 354 WFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGT 413

Query: 408 GLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHA 467
            L     + V    +   T  A +GK    ++F   YLFT ELYPT +RQ GMG  ++  
Sbjct: 414 ALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVG 473

Query: 468 RLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKE 527
           RLGG  APL   L      LP +++G  A+LA     +L ETR   L ETI  +ER+   
Sbjct: 474 RLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERK--- 530

Query: 528 GSSKKHVEEKSEEISLQQLR 547
            S+   ++E  EE+ ++Q++
Sbjct: 531 -SAPTSLQE--EEMPMKQVQ 547


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  259 bits (662), Expect = 4e-69
 Identities = 187/550 (34%), Positives = 266/550 (48%), Gaps = 46/550 (8%)

Query: 2   AFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHH--CRGPANHTEAS 59
           +F + L  +G  GRFQ     LLL   G+     F+        P H  CRGP+    A 
Sbjct: 3   SFDEALQRVGEFGRFQ-RRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAE 61

Query: 60  T---NDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLS---------------------P 95
               +    W R T P  +   PEP  R  + Q  LL                      P
Sbjct: 62  RCGWSPEEEWNR-TAPASR--GPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFP 118

Query: 96  NSSIPGAATEGCKDGWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFG 155
           N S P      C+ GW Y ++   STIV E+DLVC    + DL Q++   G L GA   G
Sbjct: 119 NRSAPLVP---CRGGWRYAQA--HSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLG 173

Query: 156 SLADRLGCKGPLVWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEW 215
             ADR G     + S L +  +G   A+  +F  + +FRFL G+   G  +    +V E 
Sbjct: 174 YAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEI 233

Query: 216 MPTRGRTVAGILLGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSR 275
           + ++ R + GI++   FTLG +IL G+AY I  W+ +Q AI+ P  +F LY W +PES R
Sbjct: 234 VGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPR 293

Query: 276 WLLLHGKSQLAVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSN-SILDLFRT 334
           WL+   K   A+Q L+++A  NG         K + S+Y +        SN S LDL RT
Sbjct: 294 WLITRKKGDKALQILRRIAKCNG---------KYLSSNYSEITVTDEEVSNPSFLDLVRT 344

Query: 335 PAIRKVTCCLMVIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYV 394
           P +RK T  LM  WF+++V Y GL M L   G +LY+   + G++  P  L+   T+  +
Sbjct: 345 PQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERL 404

Query: 395 GRRATVASFLILAGLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTE 454
           GRR   A+  I+AG+  +   F+PEG   L T  A LG+  +  +F  VYL   ELYPT 
Sbjct: 405 GRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTT 464

Query: 455 IRQMGMGFASVHARLGGLTAP-LVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMP 513
           +R  G+   S     GG+ AP L+  L      LP + FG  A + G  V +L ET+ + 
Sbjct: 465 LRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIA 524

Query: 514 LVETIAAMER 523
           L ET+  +E+
Sbjct: 525 LPETVDDVEK 534


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  241 bits (615), Expect = 1e-63
 Identities = 177/564 (31%), Positives = 266/564 (47%), Gaps = 38/564 (6%)

Query: 10  LGSMGRFQLNHTALL---LLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEASTNDSGAW 66
           LG  G FQ     LL   ++P G     +    F  A P H CR P      + N S AW
Sbjct: 11  LGEWGPFQRLIFFLLSASIIPNGFTGLSSV---FLIATPEHRCRVPD-----AANLSSAW 62

Query: 67  LRATIPL---DQLGAPEPCRRFTKPQWALLSPNSSIPGAAT-------EGCKDGWVYNRS 116
              T+PL   D    P  CRR+     A  S     PG          E C DGW +++ 
Sbjct: 63  RNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122

Query: 117 VFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAA 176
           V+ STIV EW+LVCE      L  S++  GVL+G+ + G L+DR G K  L  +      
Sbjct: 123 VYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTG 182

Query: 177 SGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVA------GILLGY 230
                 +  +F  + V   L+GM   G I N V+  V      G++V       G+ + Y
Sbjct: 183 FSFLQIFSKNFEMFVVLFVLVGM---GQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFY 239

Query: 231 SFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNL 290
           +F  G ++L   AY IR WR L  A++ P ++     W++PES RWL+  G+ + A   +
Sbjct: 240 AF--GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVII 297

Query: 291 QKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFS 350
           +K A  NG              S +Q   +    S++ILDL RT  IR VT   +++W +
Sbjct: 298 RKAAKANGIVVPSTIFDP----SELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMT 353

Query: 351 NSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLM 410
            SV Y+GL++D       +++   L  ++  PA ++A   + Y+ RR ++A+ L L G +
Sbjct: 354 ISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSV 413

Query: 411 VIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLG 470
           ++    VP     L T    +GK  + ++F  VY++T ELYPT +R MG+G +S  +RLG
Sbjct: 414 LLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLG 473

Query: 471 GLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGSS 530
            + +P    LG Y   LP +  G+  IL  +    L E+   PL +TI  M R   +G  
Sbjct: 474 SILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLR--VKGMK 531

Query: 531 KKHVEEKSEEISLQQLRASPLKET 554
            +     +  +   Q R + LK T
Sbjct: 532 HRKTPSHTRMLKDGQERPTILKST 555


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  231 bits (589), Expect = 1e-60
 Identities = 117/312 (37%), Positives = 184/312 (58%)

Query: 213 VEWMPTRGRTVAGILLGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPE 272
           +EW   R R +   L    F+ G  + A VAY +R W  LQ  +S PF + FLYSWWL E
Sbjct: 1   MEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAE 60

Query: 273 SSRWLLLHGKSQLAVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLF 332
           S+RWLL  G+    +Q L +VAA+NG+    + LT EV+ S ++ E +      S+  L 
Sbjct: 61  SARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLL 120

Query: 333 RTPAIRKVTCCLMVIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMI 392
           R P +R  TC   + WF+    ++GLA+DLQ  G +++L+Q   G+++ PA + A   + 
Sbjct: 121 RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLS 180

Query: 393 YVGRRATVASFLILAGLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYP 452
           ++GRR T+A+ L+LAGL ++AN  VP     L +A A LG G + ++F C+ +++ EL+P
Sbjct: 181 HLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFP 240

Query: 453 TEIRQMGMGFASVHARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNM 512
           T +R   +G   + AR G +  PLV  LG +   LP + +G   +L+GLA  +L ET+++
Sbjct: 241 TVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSL 300

Query: 513 PLVETIAAMERR 524
           PL +TI  ++ +
Sbjct: 301 PLPDTIQDVQNQ 312


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  228 bits (582), Expect = 9e-60
 Identities = 178/562 (31%), Positives = 264/562 (46%), Gaps = 38/562 (6%)

Query: 5   DLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEASTNDSG 64
           D+L+  G    FQ     LL L     A       F    P H CR P     A  +   
Sbjct: 7   DVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPG---VAELSLRC 63

Query: 65  AW-----LRATIPLDQLG---APEPCRRF-----------TKPQWALLSPNSSIPGAATE 105
            W     L  T+P        +P  CRR+             P  +L +  S +P     
Sbjct: 64  GWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGP-- 121

Query: 106 GCKDGWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKG 165
            C+DGWVY      S+IV E++LVC    + DL QS    G  +G+   G +ADR G K 
Sbjct: 122 -CRDGWVYETP--GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKL 178

Query: 166 PLVWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAG 225
            L+ + L  AA+G   A   +++   +FR + G+      L    L+ E++  R R   G
Sbjct: 179 CLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVG 238

Query: 226 ILLGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQL 285
           I    ++T+G L+LAGVAY +  WR LQF ++ P   F LY W +PES RWL+   K+  
Sbjct: 239 IFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAE 298

Query: 286 AVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLM 345
           A++ ++ +A     K+ G+ L   +    ++ E      + S LDL RTP IRK T  LM
Sbjct: 299 AMRIIKHIA-----KKNGKSLPASLQRLRLEEETGKK-LNPSFLDLVRTPQIRKHTMILM 352

Query: 346 VIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLI 405
             WF++SV Y GL M +   G ++YL      ++  PA  +   T+  +GRR   A+  +
Sbjct: 353 YNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNM 412

Query: 406 LAGLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASV 465
           +AG   +A++F+P   Q L    + LG+  +  ++  V L   ELYPT IR +G+   S 
Sbjct: 413 VAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSS 472

Query: 466 HARLGGLTAP-LVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERR 524
              +GG+  P LV  L      LP + FG   ++AG  V +L ET+   L ETI   E  
Sbjct: 473 MCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENM 532

Query: 525 VKEGSSKKHVEEKSEEISLQQL 546
            +   +K    EK   + +Q+L
Sbjct: 533 QRPRKNK----EKMIYLQVQKL 550


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  220 bits (561), Expect = 2e-57
 Identities = 168/549 (30%), Positives = 255/549 (46%), Gaps = 34/549 (6%)

Query: 5   DLLDALGSMGRFQLNHTALLLLPCGLLA--CHNFLQNFTAAVPPHHCRGPANHTEASTND 62
           D+L+ +G  G FQ     +L L     A  C   +  F    P HHC+ P     A  + 
Sbjct: 6   DILEQVGESGWFQKQAFLILCLLSAAFAPICVGIV--FLGFTPDHHCQSPG---VAELSQ 60

Query: 63  SGAW-----LRATIP-LDQLGAP--EPCRRFTKPQW--ALLSPNSSIPGAATEG------ 106
              W     L  T+P L   G      CRR+ +  W  + LS    +   AT        
Sbjct: 61  RCGWSPAEELNYTVPGLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASLATNRSHLPLG 119

Query: 107 -CKDGWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKG 165
            C+DGWVY+     S+IV E++LVC      DL QS   AG L G+   G  ADR G K 
Sbjct: 120 PCQDGWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKL 177

Query: 166 PLVWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAG 225
            L+ + L  A SG   A+  ++ +  +FR L G+   G  +   +L+ E++ +  R    
Sbjct: 178 CLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVA 237

Query: 226 ILLGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQL 285
           I+   +FT+G + L G+AY +  WR LQ A+S P  +F LY W +PES RWLL   ++  
Sbjct: 238 IMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTE 297

Query: 286 AVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLM 345
           A++ +  +A  NG      +L    +      E  +   S S  DLFRTP +RK T  LM
Sbjct: 298 AIKIMDHIAQKNG------KLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILM 351

Query: 346 VIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLI 405
            +WF++SV Y GL + +     +LYL      ++  P   +A  T+  VGR   +A   +
Sbjct: 352 YLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNL 411

Query: 406 LAGLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASV 465
           LAG   +  +F+      L      +G+  +  +   + L   ELYPT +R +G+   S 
Sbjct: 412 LAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSS 471

Query: 466 HARLGGLTAP-LVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERR 524
              +GG+  P +V  L E    LP + F    +LA     +L ET+ + L ET+   E  
Sbjct: 472 LCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENL 531

Query: 525 VKEGSSKKH 533
            ++   K++
Sbjct: 532 GRKAKPKEN 540


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  219 bits (559), Expect = 4e-57
 Identities = 161/551 (29%), Positives = 256/551 (46%), Gaps = 29/551 (5%)

Query: 3   FTDLLDALGSMGRFQ---LNHTALLLLPCGLLACHNFLQNFTAAVPPHH-CRGPAN---- 54
           F  + D +G  GRFQ       A   + CG+    ++L +    V PHH CR P N    
Sbjct: 6   FEGIYDHVGHFGRFQRVLYFICAFQNISCGI----HYLASVFMGVTPHHVCRPPGNVSQV 61

Query: 55  ----HTEASTNDSGAWLRA------TIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAAT 104
               H+  S  D+GA L +      T+ L      E  R     +    S      G+  
Sbjct: 62  VFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKK 121

Query: 105 E-GCKDGWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGC 163
           E  C DG++Y+++ + ST V +W+LVC+ + L  L Q ++M GVL+G+  FG  +DRLG 
Sbjct: 122 EFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGR 181

Query: 164 KGPLVWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTV 223
           +  L  +   +   G A A+   +  +   RF + M  SG ++     V+E++  + RT 
Sbjct: 182 RVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW 241

Query: 224 AGILLGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKS 283
           A + L   F +G L++A   YL+R W   Q  +S   + F L  W LPE+  WLL  G+ 
Sbjct: 242 ASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRY 301

Query: 284 QLAVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCT---SNSILDLFRTPAIRKV 340
           + A + +  +A  N           E++S  +Q   ++  T    +++  LF   +I K 
Sbjct: 302 EEAQKIVDIMAKWN---RASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKR 358

Query: 341 TCCLMVIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATV 400
           T  + +IWF+ S+ +Y  +++    G + YL   L G++  PA       M  VGRR  +
Sbjct: 359 TLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVL 418

Query: 401 ASFLILAGLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGM 460
           A  L  + L     M +P+   IL    A +GK  + ++F  +YL+T ELYPT +R + +
Sbjct: 419 AYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAV 478

Query: 461 GFASVHARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAA 520
           G  S+  RL  + AP    L      +P +  G  A+L+G+    L ET    L  T   
Sbjct: 479 GSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEE 538

Query: 521 MERRVKEGSSK 531
             +   E  SK
Sbjct: 539 AAKLESENESK 549


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  219 bits (557), Expect = 7e-57
 Identities = 168/554 (30%), Positives = 252/554 (45%), Gaps = 35/554 (6%)

Query: 3   FTDLLDALGSMGRFQLNHTALL---LLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAS 59
           + +++  LG  G FQ     LL   ++P G    +     F A  P H CR P      +
Sbjct: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGF---NGMSVVFLAGTPEHRCRVPD-----A 55

Query: 60  TNDSGAWLRATIPL---DQLGAPEPCRRFTKPQWALLSPNSSIPGAAT-------EGCKD 109
            N S AW   ++PL   D    P  C R+     A  S     PG          E C D
Sbjct: 56  ANLSSAWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLD 115

Query: 110 GWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVW 169
           GW +++ V+ ST+V EW+LVCE      L  S++  GVL+G+ V G L+DR G K  L  
Sbjct: 116 GWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFA 175

Query: 170 SYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGIL-- 227
           +            +  S+  + V   ++GM   G I N V   +      G++V  I   
Sbjct: 176 TMAVQTGFSFLQIFSISWEMFTVLFVIVGM---GQISNYVVAFILGTEILGKSVRIIFST 232

Query: 228 LGYS--FTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQL 285
           LG    F +G ++L   AY IR WR L  A++ P ++     W++PES RWL+   + + 
Sbjct: 233 LGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFRE 292

Query: 286 AVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLM 345
           A   +QK A MN               + ++ + A       ILDLFRT  I  +T   +
Sbjct: 293 AEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAF------ILDLFRTRNIAIMTIMSL 346

Query: 346 VIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLI 405
           ++W   SV Y+ L++D        YL   L  +I  PA + A   +  + RR  +A+ L 
Sbjct: 347 LLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLF 406

Query: 406 LAGLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASV 465
             G +++    VP     L      LGK  + S+F  +Y+FT ELYPT +R M +G  S 
Sbjct: 407 WGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTST 466

Query: 466 HARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRV 525
            +R+G + AP    LG Y+ +LP +  G+  +L G+      E+  M L ET+  M+ +V
Sbjct: 467 ASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQ-KV 525

Query: 526 KEGSSKKHVEEKSE 539
           K   S K   +  E
Sbjct: 526 KWFRSGKKTRDSME 539


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score =  214 bits (544), Expect = 2e-55
 Identities = 159/553 (28%), Positives = 264/553 (47%), Gaps = 39/553 (7%)

Query: 3   FTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEASTND 62
           F +LLDA+G  G FQ    AL  +P  + A   F  +F       +C             
Sbjct: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLS 111

Query: 63  SGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAA--TEGCKDGWVYNRSVFPS 120
               L  TIP    G+   C  +    W L   +S I      T+ C+DGW+Y  +   S
Sbjct: 112 KAEQLNLTIPQAPNGSFLTCFMYLPVPWNL---DSIIQFGLNDTDTCQDGWIYPDAKKRS 168

Query: 121 TIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAA 180
            ++ E+DLVC   T +D AQ ++MAG+ +G+ +F  + D++G    ++ S L L   G  
Sbjct: 169 -LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFG 227

Query: 181 TAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILA 240
           TA+ +SF  Y  FRF +  +  G  ++S+SL  EW+    R  A IL    F +G ++L 
Sbjct: 228 TAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLT 287

Query: 241 GVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRK 300
           G+AY +  W+ L        + F  Y W LPES RWL++ GK + A Q L   A++N   
Sbjct: 288 GIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVN--- 344

Query: 301 EEGERLTKEVMSSYIQSEF---ASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYG 357
                  K+ + S +  E        T  S+LD  +   + KVT  +  +WF+ S  Y+ 
Sbjct: 345 -------KKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFT 397

Query: 358 LAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFV 417
           L++ +++ G+S++    +  I+  PA L     +  +GR+ ++A  L+ A +  +  +F+
Sbjct: 398 LSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFL 457

Query: 418 PEGTQIL------CTAQ---------AALGKGCLASSFICVYLFTGELYPTEIRQMGMGF 462
           PEG   L      C A            L +  LA++    +L+T EL PT +R  G+G 
Sbjct: 458 PEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGL 517

Query: 463 ASVHARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETI---A 519
            S+ +  G + +  +T + +  ++LP       AI+A     +L ETR+ PL E++   +
Sbjct: 518 VSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSS 575

Query: 520 AMERRVKEGSSKK 532
            +  +VK+  +K+
Sbjct: 576 QIRNKVKDMKTKE 588


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  206 bits (525), Expect = 3e-53
 Identities = 136/411 (33%), Positives = 207/411 (50%), Gaps = 16/411 (3%)

Query: 120 STIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGA 179
           ++I  EW L+         A S + +GV VG   FG L+DR G K   +  +        
Sbjct: 95  TSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAI 154

Query: 180 ATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLIL 239
           A  +  S+  + V RFL+GM   G+ L +  L+ E + T    +AG + G  F +G    
Sbjct: 155 ANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQY 214

Query: 240 AGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGR 299
           A + Y IR WR L   ++    + FL S ++PES RWL   G+   A + L  +A  N +
Sbjct: 215 ALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRK 274

Query: 300 KEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLA 359
            +    LT     S  ++         S LDLFR   +   T  LM IWF  S+ YYGL 
Sbjct: 275 LKCTFSLTHPANRSCRET--------GSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLT 326

Query: 360 MDLQKFGLSLYLVQALFGIINTPA--MLVATATMIYVGRRATVASFLILAGLMVIANMFV 417
           +     G S+Y   AL G+I  P+  + +      + GR+ T+++FL L GL  +  MF+
Sbjct: 327 LSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFL 386

Query: 418 PE--GTQILCTAQA----ALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGG 471
           PE   T +     +     LGK  ++++F  VY++T ELYPT IR +G+G  S+ +R+GG
Sbjct: 387 PEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGG 446

Query: 472 LTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAME 522
           + AP + +L      LP + FGAT + +GL   +L ET N PL+ET + ++
Sbjct: 447 IIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  193 bits (491), Expect = 3e-49
 Identities = 147/474 (31%), Positives = 220/474 (46%), Gaps = 33/474 (6%)

Query: 5   DLLDALGSMGRFQLNHTALLLLPCGLLA--CHNFLQNFTAAVPPHHCRGPANHTEASTND 62
           D+L+ +G  G FQ     +L L     A  C   +  F    P HHC+ P     A  + 
Sbjct: 6   DILEQVGESGWFQKQAFLILCLLSAAFAPICVGIV--FLGFTPDHHCQSPG---VAELSQ 60

Query: 63  SGAW-----LRATIP-LDQLGAP--EPCRRFTKPQW--ALLSPNSSIPGAATEG------ 106
              W     L  T+P L   G      CRR+ +  W  + LS    +   AT        
Sbjct: 61  RCGWSPAEELNYTVPGLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASLATNRSHLPLG 119

Query: 107 -CKDGWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKG 165
            C+DGWVY+     S+IV E++LVC      DL QS   AG L G+   G  ADR G K 
Sbjct: 120 PCQDGWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKL 177

Query: 166 PLVWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAG 225
            L+ + L  A SG   A+  ++ +  +FR L G+   G  +   +L+ E++ +  R    
Sbjct: 178 CLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVA 237

Query: 226 ILLGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQL 285
           I+   +FT+G + L G+AY +  WR LQ A+S P  +F LY W +PES RWLL   ++  
Sbjct: 238 IMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTE 297

Query: 286 AVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLM 345
           A++ +  +A  NG      +L    +      E  +   S S  DLFRTP +RK T  LM
Sbjct: 298 AIKIMDHIAQKNG------KLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILM 351

Query: 346 VIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLI 405
            +WF++SV Y GL + +     +LYL      ++  P   +A  T+  VGR   +A   +
Sbjct: 352 YLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNL 411

Query: 406 LAGLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMG 459
           LAG   +  +F+      L      +G+  +  +   + L   ELYPT +  +G
Sbjct: 412 LAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVG 465


>gi|24308167 SV2 related protein [Homo sapiens]
          Length = 548

 Score =  129 bits (325), Expect = 5e-30
 Identities = 111/412 (26%), Positives = 185/412 (44%), Gaps = 47/412 (11%)

Query: 138 LAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAATAYFSSFSAYCVFRFLM 197
           L  SV   G++  + ++G+++D+ G K  L  S L     G  +A+   +S   V R L+
Sbjct: 124 LLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLV 183

Query: 198 GMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILAGVAYLIRP---WRCLQF 254
           G    G+   SV+L  E++P + R    +L+   + +G +    +A  + P   WR L  
Sbjct: 184 GFGIGGVP-QSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLI 242

Query: 255 AISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRKEEGERLTKEVMSSY 314
             + P L+F +  +WLPES+R+ +L G  + A+  L+++A  NG       L K ++S  
Sbjct: 243 LSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMP---LGKLIISRQ 299

Query: 315 IQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLAMDLQKF-------GL 367
                        + DLF TP  R  T  L  IWFSN+ +YYGL +   +        G+
Sbjct: 300 ED--------RGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGI 350

Query: 368 SL--------------------YLVQALFGIINTPAMLVATATMIYVGRRATVASFLILA 407
           S                     Y+      +   P +LV    +  +GR+ T+A   ++ 
Sbjct: 351 SSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIF 410

Query: 408 GLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHA 467
               +  +F+  G  +L T    + +  ++  F   Y++T E+YPT  R +G+G  S  A
Sbjct: 411 SFCSLL-LFICVGRNVL-TLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMA 468

Query: 468 RLGGLTAPLVT-TLGEYSTILPPVSFGATAILAGLAVCVL-TETRNMPLVET 517
           R+G L  P +   + E S  L    +    +LA LA C L  ET+   L E+
Sbjct: 469 RVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520


>gi|170650643 solute carrier family 22, member 23 isoform a [Homo
           sapiens]
          Length = 686

 Score =  127 bits (318), Expect = 3e-29
 Identities = 132/563 (23%), Positives = 228/563 (40%), Gaps = 48/563 (8%)

Query: 6   LLDALGSMGR-FQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST---- 60
           +L  LG +G  +Q     L  +P   +    F  +F    P   CRG    TE +     
Sbjct: 84  VLPFLGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTELAGVTTT 143

Query: 61  ---NDSGAWLR------ATIPLDQLGAPEPCRRF----TKPQWALLSPNSSIPGAATEGC 107
               D G W        AT P +  G            T P   L SP      A+   C
Sbjct: 144 GRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGGDTPP---LPSPPDKGDNASNCDC 200

Query: 108 KDGWVYN-RSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGP 166
           +  W Y  R+     +V +WDLVC+      +A+   + G++ G  + G +AD +G +  
Sbjct: 201 R-AWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPV 259

Query: 167 LVWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGI 226
           L++S + +   G   A   + + +   RF  G   +GIIL   +L +E  P   R +  +
Sbjct: 260 LLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITM 319

Query: 227 LLGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLA 286
           +  +    GQ ++ G+A L R W+ LQ  I  PFL+  LY    PES RWL+   + + A
Sbjct: 320 VASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESA 379

Query: 287 VQNLQKVAAMNGRKEEGE------RLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKV 340
            + +      N    EG+       L KE+     +     V  + ++        +  +
Sbjct: 380 KRLILHFTQKNRMNPEGDIKGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSL 439

Query: 341 TCCLMVIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATV 400
           T   +   F+ S+  + + + L +   + Y   A   +++  AM V      ++GRR  +
Sbjct: 440 TGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVVR---FLGRRGGL 496

Query: 401 ASFLILAGLMVIANM----FVPEGTQILCTAQAALGKGCLASSFICVYLFT--------- 447
             F+IL  L  +  +     + + +Q   +  +   K   + +F  V +F          
Sbjct: 497 LLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSV 556

Query: 448 ---GELYPTEIRQMGMGFASVHARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVC 504
               E+ PT IR  G+G     A  G LTAP++    +    L  + F    ++  + + 
Sbjct: 557 FFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICIL 616

Query: 505 VLTETRNMPLVETIAAMERRVKE 527
           +L E+R+  L E I+  E   ++
Sbjct: 617 LLPESRDQNLPENISNGEHYTRQ 639


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  112 bits (280), Expect = 9e-25
 Identities = 106/424 (25%), Positives = 177/424 (41%), Gaps = 18/424 (4%)

Query: 107 CKDGWVYNR-SVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKG 165
           C   W YN   V  +  + +WDLVC+      L Q +++ G   G    G  ADR G +G
Sbjct: 70  CLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRG 129

Query: 166 PLVWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGR---T 222
            ++ +   +   G   A   S +     RFL+G   +G+ L    + +E      R    
Sbjct: 130 IVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVA 189

Query: 223 VAGILLGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSW--WLPESSRWLLLH 280
           +AG L+G     G  +  G+A + + WR LQ  I+AP ++F  Y W     ES+RWL++ 
Sbjct: 190 LAGELVGVG---GHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVK 246

Query: 281 GKSQLAVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKV 340
            + + A   L+ +A  N  +  G+ L +E   +    E      + S          R +
Sbjct: 247 RQIEEAQSVLRILAERN--RPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNI 304

Query: 341 TCCLMVIWFSNSVAYYGLAMDLQKFG-----LSLYLVQALFGIINTPAMLVATATMIYVG 395
              L+++ F+N +A + +    Q  G        YL   L       A +    T+   G
Sbjct: 305 WKNLLILGFTNFIA-HAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFG 363

Query: 396 RRATVASFLILAGLMVIANMFVPEG-TQILCTAQAALGKGCLASSFICVYLFTGELYPTE 454
           RR  +   + L G+  +  + + +   +   T  + LG     ++ I   L   E+ PT 
Sbjct: 364 RRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTT 423

Query: 455 IRQMGMGFASVHARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPL 514
           +R  G+G       LGGL+ P       +   L  V   A A+L  L++ +L ET+   L
Sbjct: 424 VRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLL 483

Query: 515 VETI 518
            E +
Sbjct: 484 PEVL 487


>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score =  111 bits (277), Expect = 2e-24
 Identities = 145/541 (26%), Positives = 219/541 (40%), Gaps = 46/541 (8%)

Query: 6   LLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCR-GPANHTEASTNDSG 64
           +L A G  GR +    +   +PC +L      +    A P  HCR  P     A     G
Sbjct: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66

Query: 65  -AWLRATIP-LDQLGAPEPCRRFTKPQWALLSPNSSIPGAATEGCKDGWVYNRSVFPSTI 122
            A L A IP L    AP        P +  L+P +  P  ++     G     +      
Sbjct: 67  PALLDAAIPRLGPTRAPAEALGVLSPSY--LAPLTRAPRPSSWASCSGAAAGPT------ 118

Query: 123 VMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAATA 182
              W+LVC       L Q  ++ G L+G  + G+  DR G +   V S +     GA+ A
Sbjct: 119 ---WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEA 175

Query: 183 YFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILAGV 242
             +SF    V R L G T +G +L      +E      R    +  G    +G L+L G+
Sbjct: 176 LAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGL 235

Query: 243 AYLIRPWRCLQ---FAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGR 299
           A L++ WR LQ     +S   L+F+ +    PES  WLL  G+   A + L + A  +G 
Sbjct: 236 AALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGV 295

Query: 300 KEEGERLTKEVMSSYIQSEFASVCTS----NSILDLFRTPAIRKVTCCLMVIWFSNSVA- 354
                 L +  +++  +    S  +     +S L L RT    +     +++ FS+ V  
Sbjct: 296 GPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNG---LILGFSSLVGG 352

Query: 355 ------YYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAG 408
                    LA  +  F L  +L   L       A++    T    GRR      ++L G
Sbjct: 353 GIRASFRRSLAPQVPTFYLPYFLEAGL----EAAALVFLLLTADCCGRRP-----VLLLG 403

Query: 409 LMV--IANMFVPEGTQIL--CTAQAALGKGCLASSFICVY--LFTGELYPTEIRQMGMGF 462
            MV  +A++ +  G Q L   T       G LAS  +     LF  E++PT IR  G+G 
Sbjct: 404 TMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGL 463

Query: 463 ASVHARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAME 522
                 LG    PL T  G     L  V F + A+LA L V +L E+R+  L +++   +
Sbjct: 464 VLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDAD 523

Query: 523 R 523
           R
Sbjct: 524 R 524


>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
           [Homo sapiens]
          Length = 560

 Score =  109 bits (272), Expect = 8e-24
 Identities = 143/538 (26%), Positives = 219/538 (40%), Gaps = 38/538 (7%)

Query: 6   LLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCR-GPANHTEASTNDSG 64
           +L A G  GR +    +   +PC +L      +    A P  HCR  P     A     G
Sbjct: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66

Query: 65  -AWLRATIP-LDQLGAPEPCRRFTKPQWALLSPNSSIPGAATEGCKDGWVYNRSVFPSTI 122
            A L A IP L    A  PC        + L+P +  P  ++     G     +      
Sbjct: 67  PALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT------ 120

Query: 123 VMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAATA 182
              W+LVC       L Q  ++ G L+G  + G+  DR G +   V S +     GA+ A
Sbjct: 121 ---WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEA 177

Query: 183 YFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILAGV 242
             +SF    V R L G T +G +L      +E      R    +  G    +G L+L G+
Sbjct: 178 LAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGL 237

Query: 243 AYLIRPWRCLQ---FAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGR 299
           A L++ WR LQ     +S   L+F+ +    PES  WLL  G+   A + L + A  +G 
Sbjct: 238 AALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGV 297

Query: 300 KEEGERLTKEVMSSYIQSEFASVCTS----NSILDLFRTPAIRKVTCCLMVIWFSNSVAY 355
                 L +  +++  +    S  +     +S L L RT    +VT    +I   +S+  
Sbjct: 298 GPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRT----RVTWRNGLILGFSSLVG 353

Query: 356 YGLAMDLQKFGL----SLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMV 411
            G+    ++       + YL   L   +   A++    T    GRR      ++L G MV
Sbjct: 354 GGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRP-----VLLLGTMV 408

Query: 412 --IANMFVPEGTQIL--CTAQAALGKGCLASSFICVY--LFTGELYPTEIRQMGMGFASV 465
             +A++ +  G Q L   T       G LAS  +     LF  E++PT IR  G+G    
Sbjct: 409 TGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLG 468

Query: 466 HARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMER 523
              LG     L T  G     L  V F + A+LA L V +L E+R+  L +++   +R
Sbjct: 469 AGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADR 526


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.136    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,495,220
Number of Sequences: 37866
Number of extensions: 829270
Number of successful extensions: 2756
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 2583
Number of HSP's gapped (non-prelim): 82
length of query: 555
length of database: 18,247,518
effective HSP length: 107
effective length of query: 448
effective length of database: 14,195,856
effective search space: 6359743488
effective search space used: 6359743488
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.