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Search of human proteins with 238550159
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|238550159 estrogen-related receptor beta [Homo sapiens]
(508 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|238550159 estrogen-related receptor beta [Homo sapiens] 1028 0.0
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 697 0.0
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 697 0.0
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 697 0.0
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 697 0.0
gi|18860920 estrogen-related receptor alpha [Homo sapiens] 472 e-133
gi|170295804 estrogen receptor alpha isoform 4 [Homo sapiens] 257 2e-68
gi|170295802 estrogen receptor alpha isoform 3 [Homo sapiens] 257 2e-68
gi|170295800 estrogen receptor alpha isoform 2 [Homo sapiens] 257 2e-68
gi|62821794 estrogen receptor alpha isoform 1 [Homo sapiens] 257 2e-68
gi|10835013 estrogen receptor beta isoform 1 [Homo sapiens] 238 7e-63
gi|94538328 estrogen receptor beta isoform 2 [Homo sapiens] 217 2e-56
gi|94538325 estrogen receptor beta isoform 2 [Homo sapiens] 217 2e-56
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 214 1e-55
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 213 4e-55
gi|11415052 retinoid X receptor, beta [Homo sapiens] 212 6e-55
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 195 7e-50
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 191 1e-48
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 190 3e-48
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 187 1e-47
gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo sa... 185 7e-47
gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo sa... 184 1e-46
gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo sa... 184 2e-46
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 184 2e-46
gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo sa... 183 3e-46
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 183 4e-46
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa... 182 5e-46
gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo sa... 181 1e-45
gi|110611914 progesterone receptor [Homo sapiens] 178 9e-45
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens] 176 6e-44
>gi|238550159 estrogen-related receptor beta [Homo sapiens]
Length = 508
Score = 1028 bits (2658), Expect = 0.0
Identities = 508/508 (100%), Positives = 508/508 (100%)
Query: 1 MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPP 60
MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPP
Sbjct: 1 MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPP 60
Query: 61 MFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASC 120
MFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASC
Sbjct: 61 MFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASC 120
Query: 121 EACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRG 180
EACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRG
Sbjct: 121 EACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRG 180
Query: 181 GRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKAL 240
GRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKAL
Sbjct: 181 GRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKAL 240
Query: 241 TTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLV 300
TTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLV
Sbjct: 241 TTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLV 300
Query: 301 YAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDL 360
YAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDL
Sbjct: 301 YAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDL 360
Query: 361 EAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVP 420
EAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVP
Sbjct: 361 EAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVP 420
Query: 421 MHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCPFQSAAFTSRDQSNSPGIPNPRPSSP 480
MHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCPFQSAAFTSRDQSNSPGIPNPRPSSP
Sbjct: 421 MHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCPFQSAAFTSRDQSNSPGIPNPRPSSP 480
Query: 481 TPLNERGRQISPSTRTPGGQGKHLWLTM 508
TPLNERGRQISPSTRTPGGQGKHLWLTM
Sbjct: 481 TPLNERGRQISPSTRTPGGQGKHLWLTM 508
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 697 bits (1800), Expect = 0.0
Identities = 338/435 (77%), Positives = 388/435 (89%), Gaps = 2/435 (0%)
Query: 1 MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPP 60
MS+ DRH+ SSC SFIKTEPSSP+S D+++HHSP GSSDASG + + H NGLDSPP
Sbjct: 1 MSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPP 60
Query: 61 MFAGAGL--GGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVA 118
++ A + G P RK Y+DC+S I+ED KCEYMLN++PKRLCLVCGDIASGYHYGVA
Sbjct: 61 LYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVA 120
Query: 119 SCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV 178
SCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV
Sbjct: 121 SCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV 180
Query: 179 RGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIK 238
RGGRQKYKRR+D+E+SPYL+ Q+ PAKKP KIVS+LLVAEP+K+YAMP P +P+ DIK
Sbjct: 181 RGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIK 240
Query: 239 ALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDK 298
ALTTLCDLADRELVVIIGWAKHIPGFS+LSL DQMSLLQSAWMEILILG+VYRSL ++D+
Sbjct: 241 ALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDE 300
Query: 299 LVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIE 358
LVYA+DYIMDE+ S+LAGLL+L AILQLV++YK +K+EKEEFVTLKA+ALANSDSM+IE
Sbjct: 301 LVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIE 360
Query: 359 DLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGK 418
D+EAVQKLQD+LHEALQDYE Q E+P R GK+L+TLPLLRQT+ KAVQHFY++KL+GK
Sbjct: 361 DVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGK 420
Query: 419 VPMHKLFLEMLEAKV 433
VPMHKLFLEMLEAKV
Sbjct: 421 VPMHKLFLEMLEAKV 435
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 697 bits (1800), Expect = 0.0
Identities = 338/435 (77%), Positives = 388/435 (89%), Gaps = 2/435 (0%)
Query: 1 MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPP 60
MS+ DRH+ SSC SFIKTEPSSP+S D+++HHSP GSSDASG + + H NGLDSPP
Sbjct: 1 MSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPP 60
Query: 61 MFAGAGL--GGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVA 118
++ A + G P RK Y+DC+S I+ED KCEYMLN++PKRLCLVCGDIASGYHYGVA
Sbjct: 61 LYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVA 120
Query: 119 SCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV 178
SCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV
Sbjct: 121 SCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV 180
Query: 179 RGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIK 238
RGGRQKYKRR+D+E+SPYL+ Q+ PAKKP KIVS+LLVAEP+K+YAMP P +P+ DIK
Sbjct: 181 RGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIK 240
Query: 239 ALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDK 298
ALTTLCDLADRELVVIIGWAKHIPGFS+LSL DQMSLLQSAWMEILILG+VYRSL ++D+
Sbjct: 241 ALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDE 300
Query: 299 LVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIE 358
LVYA+DYIMDE+ S+LAGLL+L AILQLV++YK +K+EKEEFVTLKA+ALANSDSM+IE
Sbjct: 301 LVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIE 360
Query: 359 DLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGK 418
D+EAVQKLQD+LHEALQDYE Q E+P R GK+L+TLPLLRQT+ KAVQHFY++KL+GK
Sbjct: 361 DVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGK 420
Query: 419 VPMHKLFLEMLEAKV 433
VPMHKLFLEMLEAKV
Sbjct: 421 VPMHKLFLEMLEAKV 435
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 697 bits (1800), Expect = 0.0
Identities = 338/435 (77%), Positives = 388/435 (89%), Gaps = 2/435 (0%)
Query: 1 MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPP 60
MS+ DRH+ SSC SFIKTEPSSP+S D+++HHSP GSSDASG + + H NGLDSPP
Sbjct: 24 MSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPP 83
Query: 61 MFAGAGL--GGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVA 118
++ A + G P RK Y+DC+S I+ED KCEYMLN++PKRLCLVCGDIASGYHYGVA
Sbjct: 84 LYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVA 143
Query: 119 SCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV 178
SCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV
Sbjct: 144 SCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV 203
Query: 179 RGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIK 238
RGGRQKYKRR+D+E+SPYL+ Q+ PAKKP KIVS+LLVAEP+K+YAMP P +P+ DIK
Sbjct: 204 RGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIK 263
Query: 239 ALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDK 298
ALTTLCDLADRELVVIIGWAKHIPGFS+LSL DQMSLLQSAWMEILILG+VYRSL ++D+
Sbjct: 264 ALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDE 323
Query: 299 LVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIE 358
LVYA+DYIMDE+ S+LAGLL+L AILQLV++YK +K+EKEEFVTLKA+ALANSDSM+IE
Sbjct: 324 LVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIE 383
Query: 359 DLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGK 418
D+EAVQKLQD+LHEALQDYE Q E+P R GK+L+TLPLLRQT+ KAVQHFY++KL+GK
Sbjct: 384 DVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGK 443
Query: 419 VPMHKLFLEMLEAKV 433
VPMHKLFLEMLEAKV
Sbjct: 444 VPMHKLFLEMLEAKV 458
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 697 bits (1800), Expect = 0.0
Identities = 338/435 (77%), Positives = 388/435 (89%), Gaps = 2/435 (0%)
Query: 1 MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPP 60
MS+ DRH+ SSC SFIKTEPSSP+S D+++HHSP GSSDASG + + H NGLDSPP
Sbjct: 1 MSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPP 60
Query: 61 MFAGAGL--GGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVA 118
++ A + G P RK Y+DC+S I+ED KCEYMLN++PKRLCLVCGDIASGYHYGVA
Sbjct: 61 LYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVA 120
Query: 119 SCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV 178
SCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV
Sbjct: 121 SCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV 180
Query: 179 RGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIK 238
RGGRQKYKRR+D+E+SPYL+ Q+ PAKKP KIVS+LLVAEP+K+YAMP P +P+ DIK
Sbjct: 181 RGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIK 240
Query: 239 ALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDK 298
ALTTLCDLADRELVVIIGWAKHIPGFS+LSL DQMSLLQSAWMEILILG+VYRSL ++D+
Sbjct: 241 ALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDE 300
Query: 299 LVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIE 358
LVYA+DYIMDE+ S+LAGLL+L AILQLV++YK +K+EKEEFVTLKA+ALANSDSM+IE
Sbjct: 301 LVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIE 360
Query: 359 DLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGK 418
D+EAVQKLQD+LHEALQDYE Q E+P R GK+L+TLPLLRQT+ KAVQHFY++KL+GK
Sbjct: 361 DVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGK 420
Query: 419 VPMHKLFLEMLEAKV 433
VPMHKLFLEMLEAKV
Sbjct: 421 VPMHKLFLEMLEAKV 435
>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
Length = 423
Score = 472 bits (1215), Expect = e-133
Identities = 252/432 (58%), Positives = 308/432 (71%), Gaps = 38/432 (8%)
Query: 15 FIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTPCRK 74
+IK EP+SP S P GSS+ PP+ G T C
Sbjct: 12 YIKAEPASPDS---------PKGSSETE--------------TEPPVALAPGPAPTRCLP 48
Query: 75 SY--EDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQ 132
+ E+ G + +L+++PKRLCLVCGD+ASGYHYGVASCEACKAFFKRTIQ
Sbjct: 49 GHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQ 108
Query: 133 GNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSE 192
G+IEYSCPA+NECEITKRRRK+CQACRF KCL+VGMLKEGVRLDRVRGGRQKYKRR + +
Sbjct: 109 GSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVD 168
Query: 193 SSPYLS------LQISPPAKK---PLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTL 243
P+ L ++ +K P+ +VS+LLV EP+KLYAMP P P+G + A+ TL
Sbjct: 169 PLPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATL 228
Query: 244 CDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAE 303
CDL DRE+VV I WAK IPGFSSLSL DQMS+LQS WME+L+LG+ RSLP D+L +AE
Sbjct: 229 CDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAE 288
Query: 304 DYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAV 363
D ++DEE +R AGL EL A+LQLVRR + L++E+EE+V LKALALANSDS++IED EAV
Sbjct: 289 DLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAV 348
Query: 364 QKLQDLLHEALQDYELSQR----HEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKV 419
++L++ LHEAL +YE + E R G+LLLTLPLLRQTA K + HFY VKL+GKV
Sbjct: 349 EQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKV 408
Query: 420 PMHKLFLEMLEA 431
PMHKLFLEMLEA
Sbjct: 409 PMHKLFLEMLEA 420
>gi|170295804 estrogen receptor alpha isoform 4 [Homo sapiens]
Length = 595
Score = 257 bits (657), Expect = 2e-68
Identities = 156/375 (41%), Positives = 222/375 (59%), Gaps = 41/375 (10%)
Query: 94 MLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRK 153
M +A R C VC D ASGYHYGV SCE CKAFFKR+IQG+ +Y CPATN+C I K RRK
Sbjct: 176 MESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRK 235
Query: 154 SCQACRFMKCLKVGMLKEGVRLDRVRGGRQ-KYKRRLDSES------------------S 194
SCQACR KC +VGM+K G+R DR RGGR K+KR+ D S
Sbjct: 236 SCQACRLRKCYEVGMMKGGIRKDR-RGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPS 294
Query: 195 PYL---SLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADREL 251
P + S + S ++VS LL AEP LY+ P P + + L +LADREL
Sbjct: 295 PLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL 354
Query: 252 VVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEH 311
V +I WAK +PGF L+L DQ+ LL+ AW+EIL++G+V+RS+ + KL++A + ++D
Sbjct: 355 VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQ 414
Query: 312 SR-LAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSD-----SMYIEDLE---- 361
+ + G++E++ +L R++ + ++ EEFV LK++ L NS S ++ LE
Sbjct: 415 GKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDH 474
Query: 362 ---AVQKLQD-LLH-EALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQ 416
+ K+ D L+H A L Q+H+ R +LLL L +R + K ++H YS+K +
Sbjct: 475 IHRVLDKITDTLIHLMAKAGLTLQQQHQ---RLAQLLLILSHIRHMSNKGMEHLYSMKCK 531
Query: 417 GKVPMHKLFLEMLEA 431
VP++ L LEML+A
Sbjct: 532 NVVPLYDLLLEMLDA 546
>gi|170295802 estrogen receptor alpha isoform 3 [Homo sapiens]
Length = 595
Score = 257 bits (657), Expect = 2e-68
Identities = 156/375 (41%), Positives = 222/375 (59%), Gaps = 41/375 (10%)
Query: 94 MLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRK 153
M +A R C VC D ASGYHYGV SCE CKAFFKR+IQG+ +Y CPATN+C I K RRK
Sbjct: 176 MESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRK 235
Query: 154 SCQACRFMKCLKVGMLKEGVRLDRVRGGRQ-KYKRRLDSES------------------S 194
SCQACR KC +VGM+K G+R DR RGGR K+KR+ D S
Sbjct: 236 SCQACRLRKCYEVGMMKGGIRKDR-RGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPS 294
Query: 195 PYL---SLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADREL 251
P + S + S ++VS LL AEP LY+ P P + + L +LADREL
Sbjct: 295 PLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL 354
Query: 252 VVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEH 311
V +I WAK +PGF L+L DQ+ LL+ AW+EIL++G+V+RS+ + KL++A + ++D
Sbjct: 355 VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQ 414
Query: 312 SR-LAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSD-----SMYIEDLE---- 361
+ + G++E++ +L R++ + ++ EEFV LK++ L NS S ++ LE
Sbjct: 415 GKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDH 474
Query: 362 ---AVQKLQD-LLH-EALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQ 416
+ K+ D L+H A L Q+H+ R +LLL L +R + K ++H YS+K +
Sbjct: 475 IHRVLDKITDTLIHLMAKAGLTLQQQHQ---RLAQLLLILSHIRHMSNKGMEHLYSMKCK 531
Query: 417 GKVPMHKLFLEMLEA 431
VP++ L LEML+A
Sbjct: 532 NVVPLYDLLLEMLDA 546
>gi|170295800 estrogen receptor alpha isoform 2 [Homo sapiens]
Length = 595
Score = 257 bits (657), Expect = 2e-68
Identities = 156/375 (41%), Positives = 222/375 (59%), Gaps = 41/375 (10%)
Query: 94 MLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRK 153
M +A R C VC D ASGYHYGV SCE CKAFFKR+IQG+ +Y CPATN+C I K RRK
Sbjct: 176 MESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRK 235
Query: 154 SCQACRFMKCLKVGMLKEGVRLDRVRGGRQ-KYKRRLDSES------------------S 194
SCQACR KC +VGM+K G+R DR RGGR K+KR+ D S
Sbjct: 236 SCQACRLRKCYEVGMMKGGIRKDR-RGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPS 294
Query: 195 PYL---SLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADREL 251
P + S + S ++VS LL AEP LY+ P P + + L +LADREL
Sbjct: 295 PLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL 354
Query: 252 VVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEH 311
V +I WAK +PGF L+L DQ+ LL+ AW+EIL++G+V+RS+ + KL++A + ++D
Sbjct: 355 VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQ 414
Query: 312 SR-LAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSD-----SMYIEDLE---- 361
+ + G++E++ +L R++ + ++ EEFV LK++ L NS S ++ LE
Sbjct: 415 GKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDH 474
Query: 362 ---AVQKLQD-LLH-EALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQ 416
+ K+ D L+H A L Q+H+ R +LLL L +R + K ++H YS+K +
Sbjct: 475 IHRVLDKITDTLIHLMAKAGLTLQQQHQ---RLAQLLLILSHIRHMSNKGMEHLYSMKCK 531
Query: 417 GKVPMHKLFLEMLEA 431
VP++ L LEML+A
Sbjct: 532 NVVPLYDLLLEMLDA 546
>gi|62821794 estrogen receptor alpha isoform 1 [Homo sapiens]
Length = 595
Score = 257 bits (657), Expect = 2e-68
Identities = 156/375 (41%), Positives = 222/375 (59%), Gaps = 41/375 (10%)
Query: 94 MLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRK 153
M +A R C VC D ASGYHYGV SCE CKAFFKR+IQG+ +Y CPATN+C I K RRK
Sbjct: 176 MESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRK 235
Query: 154 SCQACRFMKCLKVGMLKEGVRLDRVRGGRQ-KYKRRLDSES------------------S 194
SCQACR KC +VGM+K G+R DR RGGR K+KR+ D S
Sbjct: 236 SCQACRLRKCYEVGMMKGGIRKDR-RGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPS 294
Query: 195 PYL---SLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADREL 251
P + S + S ++VS LL AEP LY+ P P + + L +LADREL
Sbjct: 295 PLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL 354
Query: 252 VVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEH 311
V +I WAK +PGF L+L DQ+ LL+ AW+EIL++G+V+RS+ + KL++A + ++D
Sbjct: 355 VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQ 414
Query: 312 SR-LAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSD-----SMYIEDLE---- 361
+ + G++E++ +L R++ + ++ EEFV LK++ L NS S ++ LE
Sbjct: 415 GKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDH 474
Query: 362 ---AVQKLQD-LLH-EALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQ 416
+ K+ D L+H A L Q+H+ R +LLL L +R + K ++H YS+K +
Sbjct: 475 IHRVLDKITDTLIHLMAKAGLTLQQQHQ---RLAQLLLILSHIRHMSNKGMEHLYSMKCK 531
Query: 417 GKVPMHKLFLEMLEA 431
VP++ L LEML+A
Sbjct: 532 NVVPLYDLLLEMLDA 546
>gi|10835013 estrogen receptor beta isoform 1 [Homo sapiens]
Length = 530
Score = 238 bits (608), Expect = 7e-63
Identities = 140/356 (39%), Positives = 216/356 (60%), Gaps = 30/356 (8%)
Query: 103 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 162
C VC D ASGYHYGV SCE CKAFFKR+IQG+ +Y CPATN+C I K RRKSCQACR K
Sbjct: 149 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRK 208
Query: 163 CLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQI------SPPAKKPL------T 210
C +VGM+K G R R R G + +R+ ++ + + + +P ++ L
Sbjct: 209 CYEVGMVKCGSR--RERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPE 266
Query: 211 KIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLG 270
++V LL AEP + + P P + + +L LAD+ELV +I WAK IPGF LSL
Sbjct: 267 QLVLTLLEAEPPHV-LISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLF 325
Query: 271 DQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSR-LAGLLELYRAILQLVR 329
DQ+ LL+S WME+L++G+++RS+ + KL++A D ++D + + + G+LE++ +L
Sbjct: 326 DQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTS 385
Query: 330 RYKKLKVEKEEFVTLKALALANSDSMY-----IEDLEAVQKLQDLLHEALQDYEL----- 379
R+++LK++ +E++ +KA+ L NS SMY +D ++ +KL LL+ A+ D +
Sbjct: 386 RFRELKLQHKEYLCVKAMILLNS-SMYPLVTATQDADSSRKLAHLLN-AVTDALVWVIAK 443
Query: 380 --SQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKV 433
++ R LL+ L +R + K ++H ++K + VP++ L LEML A V
Sbjct: 444 SGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHV 499
>gi|94538328 estrogen receptor beta isoform 2 [Homo sapiens]
Length = 495
Score = 217 bits (553), Expect = 2e-56
Identities = 121/287 (42%), Positives = 183/287 (63%), Gaps = 22/287 (7%)
Query: 103 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 162
C VC D ASGYHYGV SCE CKAFFKR+IQG+ +Y CPATN+C I K RRKSCQACR K
Sbjct: 149 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRK 208
Query: 163 CLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQI------SPPAKKPL------T 210
C +VGM+K G R R R G + +R+ ++ + + + +P ++ L
Sbjct: 209 CYEVGMVKCGSR--RERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPE 266
Query: 211 KIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLG 270
++V LL AEP + + P P + + +L LAD+ELV +I WAK IPGF LSL
Sbjct: 267 QLVLTLLEAEPPHV-LISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLF 325
Query: 271 DQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSR-LAGLLELYRAILQLVR 329
DQ+ LL+S WME+L++G+++RS+ + KL++A D ++D + + + G+LE++ +L
Sbjct: 326 DQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTS 385
Query: 330 RYKKLKVEKEEFVTLKALALANSDSMY-----IEDLEAVQKLQDLLH 371
R+++LK++ +E++ +KA+ L NS SMY +D ++ +KL LL+
Sbjct: 386 RFRELKLQHKEYLCVKAMILLNS-SMYPLVTATQDADSSRKLAHLLN 431
>gi|94538325 estrogen receptor beta isoform 2 [Homo sapiens]
Length = 495
Score = 217 bits (553), Expect = 2e-56
Identities = 121/287 (42%), Positives = 183/287 (63%), Gaps = 22/287 (7%)
Query: 103 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 162
C VC D ASGYHYGV SCE CKAFFKR+IQG+ +Y CPATN+C I K RRKSCQACR K
Sbjct: 149 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRK 208
Query: 163 CLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQI------SPPAKKPL------T 210
C +VGM+K G R R R G + +R+ ++ + + + +P ++ L
Sbjct: 209 CYEVGMVKCGSR--RERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPE 266
Query: 211 KIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLG 270
++V LL AEP + + P P + + +L LAD+ELV +I WAK IPGF LSL
Sbjct: 267 QLVLTLLEAEPPHV-LISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLF 325
Query: 271 DQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSR-LAGLLELYRAILQLVR 329
DQ+ LL+S WME+L++G+++RS+ + KL++A D ++D + + + G+LE++ +L
Sbjct: 326 DQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTS 385
Query: 330 RYKKLKVEKEEFVTLKALALANSDSMY-----IEDLEAVQKLQDLLH 371
R+++LK++ +E++ +KA+ L NS SMY +D ++ +KL LL+
Sbjct: 386 RFRELKLQHKEYLCVKAMILLNS-SMYPLVTATQDADSSRKLAHLLN 431
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 214 bits (546), Expect = 1e-55
Identities = 118/335 (35%), Positives = 189/335 (56%), Gaps = 12/335 (3%)
Query: 100 KRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACR 159
K +C +CGD +SG HYGV SCE CK FFKRT++ ++ Y+C +C I KR+R CQ CR
Sbjct: 132 KHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCR 191
Query: 160 FMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVA 219
+ KCL +GM +E V+ +R R G+ + + ++S SS + P+ +I+ L
Sbjct: 192 YQKCLAMGMKREAVQEERQR-GKDRNENEVESTSSANEDM--------PVERILEAELAV 242
Query: 220 EP-DKLYAMPPPGM-PEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQ 277
EP + Y G+ P +T +C AD++L ++ WAK IP FS L L DQ+ LL+
Sbjct: 243 EPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLR 302
Query: 278 SAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELY-RAILQLVRRYKKLKV 336
+ W E+LI +RS+ D ++ A + + AG+ ++ R + +LV + + +++
Sbjct: 303 AGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQM 362
Query: 337 EKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTL 396
+K E L+A+ L N DS + + V+ L++ ++ +L+ Y + E+P R KLLL L
Sbjct: 363 DKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRL 422
Query: 397 PLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEA 431
P LR K ++H + KL G P+ +EMLEA
Sbjct: 423 PALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEA 457
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 213 bits (541), Expect = 4e-55
Identities = 117/335 (34%), Positives = 186/335 (55%), Gaps = 11/335 (3%)
Query: 97 AIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQ 156
++ K +C +CGD +SG HYGV SCE CK FFKRTI+ ++ Y+C +C I KR+R CQ
Sbjct: 133 SLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQ 192
Query: 157 ACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYL 216
CR+ KCL +GM +E V+ + RQ+ + R +SE+ S P+ +I+
Sbjct: 193 YCRYQKCLVMGMKREAVQEE-----RQRSRERAESEA----ECATSGHEDMPVERILEAE 243
Query: 217 LVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLL 276
L EP K + M +T +C AD++L ++ WAK IP FS L+L DQ+ LL
Sbjct: 244 LAVEP-KTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILL 302
Query: 277 QSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELY-RAILQLVRRYKKLK 335
++ W E+LI +RS+ D ++ A + + AG+ ++ R + +LV + K ++
Sbjct: 303 RAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQ 362
Query: 336 VEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLT 395
++K E L+A+ L N D+ + + V+ L++ ++ L+ Y + E+P R KLLL
Sbjct: 363 MDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLR 422
Query: 396 LPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLE 430
LP LR K ++H + KL G P+ +EMLE
Sbjct: 423 LPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 457
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 212 bits (540), Expect = 6e-55
Identities = 119/337 (35%), Positives = 185/337 (54%), Gaps = 15/337 (4%)
Query: 100 KRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACR 159
KRLC +CGD +SG HYGV SCE CK FFKRTI+ ++ YSC +C + KR+R CQ CR
Sbjct: 202 KRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCR 261
Query: 160 FMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVA 219
+ KCL GM +E V+ +R RG + D E + P + P+ +I+ L
Sbjct: 262 YQKCLATGMKREAVQEERQRG----KDKDGDGEGAG------GAPEEMPVDRILEAELAV 311
Query: 220 EPDKLYAMPPPGMPEGDIKA----LTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSL 275
E + PG G + +T +C AD++L ++ WAK IP FSSL L DQ+ L
Sbjct: 312 EQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVIL 371
Query: 276 LQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELY-RAILQLVRRYKKL 334
L++ W E+LI +RS+ D ++ A + + AG+ ++ R + +LV + + +
Sbjct: 372 LRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 431
Query: 335 KVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLL 394
+++K E L+A+ L N D+ + + V+ L++ ++ +L+ Y + E+ R KLLL
Sbjct: 432 RMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLL 491
Query: 395 TLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEA 431
LP LR K ++H + KL G P+ +EMLEA
Sbjct: 492 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEA 528
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 195 bits (496), Expect = 7e-50
Identities = 112/329 (34%), Positives = 170/329 (51%), Gaps = 9/329 (2%)
Query: 103 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 162
C+VCGD +SG HYG +CE CK+FFKR+++ N+ Y+C A C I + R CQ CR K
Sbjct: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
Query: 163 CLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPD 222
CLKVGM +E V+ R+ + + + + P L+ +S LL AEP
Sbjct: 139 CLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPL-------NCHSYLSGYISLLLRAEPY 191
Query: 223 KLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWME 282
M +I + +C+LA R L + WA++IP F L + DQ++LL+ W E
Sbjct: 192 PTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSE 251
Query: 283 ILILGIVYRSLPYD--DKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEE 340
+ +L S+P L A + R+ ++ R + V + K L V+ E
Sbjct: 252 LFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAE 311
Query: 341 FVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLR 400
+ LKA+ L SD+ + D+ V+ LQ+ AL++Y SQ +P R GKLLL LP LR
Sbjct: 312 YSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLR 371
Query: 401 QTAAKAVQHFYSVKLQGKVPMHKLFLEML 429
++ ++ + V+L GK P+ L +ML
Sbjct: 372 TVSSSVIEQLFFVRLVGKTPIETLIRDML 400
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 191 bits (486), Expect = 1e-48
Identities = 112/329 (34%), Positives = 168/329 (51%), Gaps = 9/329 (2%)
Query: 103 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 162
C+VCGD +SG HYG +CE CK+FFKR+++ N+ Y+C A C I + R CQ CR K
Sbjct: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
Query: 163 CLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPD 222
CLKVGM +E V+ R+ + + + P L+ +S LL AEP
Sbjct: 146 CLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPL-------NGHCYLSGYISLLLRAEPY 198
Query: 223 KLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWME 282
M +I + +C+LA R L + WA++IP F L + DQ+SLL+ W E
Sbjct: 199 PTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSE 258
Query: 283 ILILGIVYRSLPYD--DKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEE 340
+ +L S+P L A + R+ ++ R + V + K L V+ E
Sbjct: 259 LFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAE 318
Query: 341 FVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLR 400
+ LKA+ L SD+ + D ++ LQ+ AL++Y SQ +P R GKLLL LP LR
Sbjct: 319 YSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLR 378
Query: 401 QTAAKAVQHFYSVKLQGKVPMHKLFLEML 429
++ ++ + V+L GK P+ L +ML
Sbjct: 379 TVSSSVIEQLFFVRLVGKTPIETLIRDML 407
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 190 bits (482), Expect = 3e-48
Identities = 113/336 (33%), Positives = 174/336 (51%), Gaps = 10/336 (2%)
Query: 103 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 162
C+VCGD +SG HYGV +CE CK+FFKR+I+ N+ Y+C + +C+I + R CQ CR K
Sbjct: 56 CVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKK 115
Query: 163 CLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAK-----KPLTKIVSYLL 217
C +VGM KE V+ R+ S S P +L +P++++++ LL
Sbjct: 116 CFRVGMRKEAVQRGRIPHSLPGAVAA-SSGSPPGSALAAVASGGDLFPGQPVSELIAQLL 174
Query: 218 VAEPDKLYA--MPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSL 275
AEP A G G + + +C+LA R L + WA+H P F L + DQ++L
Sbjct: 175 RAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVAL 234
Query: 276 LQSAWMEILILGIVYRSLPYDDK--LVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKK 333
L+ +W E+ +L +LP L A + R ++ RA + V + +
Sbjct: 235 LRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGR 294
Query: 334 LKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLL 393
L+V+ E+ LKA+AL D+ + D V+ LQ+ AL +Y +Q +P R G+LL
Sbjct: 295 LQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLL 354
Query: 394 LTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEML 429
L LP LR A + + ++L GK P+ L +ML
Sbjct: 355 LRLPALRAVPASLISQLFFMRLVGKTPIETLIRDML 390
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 187 bits (476), Expect = 1e-47
Identities = 136/439 (30%), Positives = 207/439 (47%), Gaps = 33/439 (7%)
Query: 37 GSSDASGGFGLALGTHANGLDSPPM------FAGAGLGGTPCRKSYEDCASGIMEDSAIK 90
GS GF A G SPP F G G P ++ AS +E +
Sbjct: 17 GSGYPGAGFPFAFPGALRG--SPPFEMLSPSFRGLGQPDLP-----KEMASLSVETQSTS 69
Query: 91 CEYMLNAIPK--------RLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPAT 142
E M+ + P + C VC D +SGYHYGV+SCE CK FF+R+IQ N+ Y+C
Sbjct: 70 SEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRD 129
Query: 143 NECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQIS 202
C I K R CQ CR KC +VGM KE VR D R K K+ + E SP S ++S
Sbjct: 130 KNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRND-----RNKKKKEVKEEGSPD-SYELS 183
Query: 203 PPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTL------CDLADRELVVIIG 256
P ++ +TK+ P D + L +LA + ++ I+
Sbjct: 184 PQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVE 243
Query: 257 WAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAG 316
+AK +PGF+ LS+ DQ++LL++A ++IL+L I R P D + +++ ++ AG
Sbjct: 244 FAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAG 303
Query: 317 LLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQD 376
L + + L+++ E L A+ L D M +E+ E V KLQ+ L EAL+
Sbjct: 304 FGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRL 363
Query: 377 YELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKVGQE 436
Y +R +P+ ++L+ + LR + K + ++K++ PM L EMLE E
Sbjct: 364 YARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFE 423
Query: 437 QLRGSPKDERMSSHDGKCP 455
P +S + + P
Sbjct: 424 DDSSQPGPHPNASSEDEVP 442
>gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo
sapiens]
Length = 452
Score = 185 bits (470), Expect = 7e-47
Identities = 132/448 (29%), Positives = 209/448 (46%), Gaps = 51/448 (11%)
Query: 69 GTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFK 128
G P SY+ S E + + L LC +CGD A+G HYG +SC+ CK FF+
Sbjct: 9 GAPVESSYDTSPS---EGTNLNAPNSLGV--SALCAICGDRATGKHYGASSCDGCKGFFR 63
Query: 129 RTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRR 188
R+++ N YSC + +C + K +R C+ CR KC + GM KE V+ +R R RR
Sbjct: 64 RSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRIS----TRR 119
Query: 189 LDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKA-----LTTL 243
E S S ++ LL AE P GDI+A + +
Sbjct: 120 SSYEDSSLPS--------------INALLQAEVLSRQITSPVSGINGDIRAKKIASIADV 165
Query: 244 CDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAE 303
C+ +L+V++ WAK+IP F L L DQ++LL++ E L+LG RS+ + D L+
Sbjct: 166 CESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGN 225
Query: 304 DYIMDEEHSRLAGLLELYRAIL-QLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEA 362
DYI+ LA + + IL +LV +++L+++ E+ LKA+ + D+ + D
Sbjct: 226 DYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGK 285
Query: 363 VQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMH 422
+++L+ + +L+DY ++++ R G+LLL LP L+ + ++ +KL G +
Sbjct: 286 IKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKID 345
Query: 423 KLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCPFQSAAFTSRDQSNSPGIPNPRPSS--- 479
L EML L GSP D + H P +N + N P+
Sbjct: 346 NLLQEML--------LGGSPSDAPHAHH----PLHPHLMQEHMGTNVI-VANTMPTHLSN 392
Query: 480 ------PTPLNERGRQISPSTRTPGGQG 501
P P + +P PGG G
Sbjct: 393 GQMCEWPRPRGQAATPETPQPSPPGGSG 420
>gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
sapiens]
Length = 442
Score = 184 bits (468), Expect = 1e-46
Identities = 121/388 (31%), Positives = 193/388 (49%), Gaps = 37/388 (9%)
Query: 69 GTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFK 128
G P SY+ S E + + L LC +CGD A+G HYG +SC+ CK FF+
Sbjct: 9 GAPVESSYDTSPS---EGTNLNAPNSLGV--SALCAICGDRATGKHYGASSCDGCKGFFR 63
Query: 129 RTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRR 188
R+++ N YSC + +C + K +R C+ CR KC + GM KE V+ +R R RR
Sbjct: 64 RSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRIS----TRR 119
Query: 189 LDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKA-----LTTL 243
E S S ++ LL AE P GDI+A + +
Sbjct: 120 SSYEDSSLPS--------------INALLQAEVLSRQITSPVSGINGDIRAKKIASIADV 165
Query: 244 CDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAE 303
C+ +L+V++ WAK+IP F L L DQ++LL++ E L+LG RS+ + D L+
Sbjct: 166 CESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGN 225
Query: 304 DYIMDEEHSRLAGLLELYRAIL-QLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEA 362
DYI+ LA + + IL +LV +++L+++ E+ LKA+ + D+ + D
Sbjct: 226 DYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGK 285
Query: 363 VQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMH 422
+++L+ + +L+DY ++++ R G+LLL LP L+ + ++ +KL G +
Sbjct: 286 IKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKID 345
Query: 423 KLFLEMLEAKVGQEQLRGSPKDERMSSH 450
L EML L GSP D + H
Sbjct: 346 NLLQEML--------LGGSPSDAPHAHH 365
>gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
sapiens]
Length = 474
Score = 184 bits (467), Expect = 2e-46
Identities = 125/415 (30%), Positives = 199/415 (47%), Gaps = 46/415 (11%)
Query: 102 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 161
LC +CGD A+G HYG +SC+ CK FF+R+++ N YSC + +C + K +R C+ CR
Sbjct: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
Query: 162 KCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEP 221
KC + GM KE V+ +R R RR E S S ++ LL AE
Sbjct: 119 KCFRAGMKKEAVQNERDRIS----TRRSSYEDSSLPS--------------INALLQAEV 160
Query: 222 DKLYAMPPPGMPEGDIKA-----LTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLL 276
P GDI+A + +C+ +L+V++ WAK+IP F L L DQ++LL
Sbjct: 161 LSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALL 220
Query: 277 QSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAIL-QLVRRYKKLK 335
++ E L+LG RS+ + D L+ DYI+ LA + + IL +LV +++L+
Sbjct: 221 RAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQ 280
Query: 336 VEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLT 395
++ E+ LKA+ + D+ + D +++L+ + +L+DY ++++ R G+LLL
Sbjct: 281 IDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLL 340
Query: 396 LPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCP 455
LP L+ + ++ +KL G + L EML L GSP D + H P
Sbjct: 341 LPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML--------LGGSPSDAPHAHH----P 388
Query: 456 FQSAAFTSRDQSNSPGIPNPRPSS---------PTPLNERGRQISPSTRTPGGQG 501
+N + N P+ P P + +P PGG G
Sbjct: 389 LHPHLMQEHMGTNVI-VANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSG 442
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 184 bits (467), Expect = 2e-46
Identities = 117/359 (32%), Positives = 181/359 (50%), Gaps = 12/359 (3%)
Query: 103 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 162
C VC D +SGYHYGV+SCE CK FF+R+IQ N+ Y+C C I K R CQ CR K
Sbjct: 79 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 138
Query: 163 CLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPD 222
C +VGM KE VR D R K K+ + E SP S ++SP ++ +TK+ P
Sbjct: 139 CFEVGMSKEAVRND-----RNKKKKEVKEEGSPD-SYELSPQLEELITKVSKAHQETFPS 192
Query: 223 KLYAMPPPGMPEGDIKALTTL------CDLADRELVVIIGWAKHIPGFSSLSLGDQMSLL 276
D + L +LA + ++ I+ +AK +PGF+ LS+ DQ++LL
Sbjct: 193 LCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLL 252
Query: 277 QSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKV 336
++A ++IL+L I R P D + +++ ++ AG L + + L++
Sbjct: 253 KAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEM 312
Query: 337 EKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTL 396
+ E L A+ L D M +E+ E V KLQ+ L EAL+ Y +R +P+ ++L+ +
Sbjct: 313 DDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKI 372
Query: 397 PLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCP 455
LR + K + ++K++ PM L EMLE E P +S + + P
Sbjct: 373 TDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVP 431
>gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo
sapiens]
Length = 464
Score = 183 bits (465), Expect = 3e-46
Identities = 114/355 (32%), Positives = 183/355 (51%), Gaps = 32/355 (9%)
Query: 102 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 161
LC +CGD A+G HYG +SC+ CK FF+R+++ N YSC + +C + K +R C+ CR
Sbjct: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
Query: 162 KCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEP 221
KC + GM KE V+ +R R RR E S S ++ LL AE
Sbjct: 119 KCFRAGMKKEAVQNERDRIS----TRRSSYEDSSLPS--------------INALLQAEV 160
Query: 222 DKLYAMPPPGMPEGDIKA-----LTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLL 276
P GDI+A + +C+ +L+V++ WAK+IP F L L DQ++LL
Sbjct: 161 LSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALL 220
Query: 277 QSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAIL-QLVRRYKKLK 335
++ E L+LG RS+ + D L+ DYI+ LA + + IL +LV +++L+
Sbjct: 221 RAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQ 280
Query: 336 VEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLT 395
++ E+ LKA+ + D+ + D +++L+ + +L+DY ++++ R G+LLL
Sbjct: 281 IDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLL 340
Query: 396 LPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKVGQEQLRGSPKDERMSSH 450
LP L+ + ++ +KL G + L EML L GSP D + H
Sbjct: 341 LPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML--------LGGSPSDAPHAHH 387
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 183 bits (464), Expect = 4e-46
Identities = 116/345 (33%), Positives = 177/345 (51%), Gaps = 27/345 (7%)
Query: 102 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 161
LC VCGD A+ HYGV +CE CK FFKRT+Q N +Y C A C + KRRR CQ CRF
Sbjct: 262 LCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQ 321
Query: 162 KCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEP 221
KCL VGM+KE VR D ++G R + + S P SPP+ P ++S L+ A
Sbjct: 322 KCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEP------SPPS--PPVSLISALVRAHV 373
Query: 222 D-----------KLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLG 270
D + A P M D + + DL + +I GWA+ IPGF+ L
Sbjct: 374 DSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKA 433
Query: 271 DQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRR 330
DQ L +SA++E+ +L + YRS P + KL++ ++ + G E +I++
Sbjct: 434 DQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQC-VRGFGEWIDSIVEFSSN 492
Query: 331 YKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRH--EEPWR 388
+ + ++ F + ALA+ ++ +++ + V++LQ+ + L+D+ P
Sbjct: 493 LQNMNIDISAFSCIAALAMV-TERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNY 551
Query: 389 TGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVP----MHKLFLEML 429
KLL LP LR + +Q + +KL+ VP + KLFL+ L
Sbjct: 552 LSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTL 596
>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
sapiens]
Length = 395
Score = 182 bits (463), Expect = 5e-46
Identities = 124/403 (30%), Positives = 198/403 (49%), Gaps = 37/403 (9%)
Query: 69 GTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFK 128
G P SY+ S E + + L LC +CGD A+G HYG +SC+ CK FF+
Sbjct: 9 GAPVESSYDTSPS---EGTNLNAPNSLGV--SALCAICGDRATGKHYGASSCDGCKGFFR 63
Query: 129 RTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRR 188
R+++ N YSC + +C + K +R C+ CR KC + GM KE V+ +R R RR
Sbjct: 64 RSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRIS----TRR 119
Query: 189 LDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKA-----LTTL 243
E S S ++ LL AE P GDI+A + +
Sbjct: 120 SSYEDSSLPS--------------INALLQAEVLSRQITSPVSGINGDIRAKKIASIADV 165
Query: 244 CDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAE 303
C+ +L+V++ WAK+IP F L L DQ++LL++ E L+LG RS+ + D L+
Sbjct: 166 CESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGN 225
Query: 304 DYIMDEEHSRLAGLLELYRAIL-QLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEA 362
DYI+ LA + + IL +LV +++L+++ E+ LKA+ + D+ + D
Sbjct: 226 DYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGK 285
Query: 363 VQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMH 422
+++L+ + +L+DY ++++ R G+LLL LP L+ + ++ +KL G +
Sbjct: 286 IKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKID 345
Query: 423 KLFLEML-----EAKVGQEQLRGSPKDERMSSHDGKCPFQSAA 460
L EML +A+ G+ SP D H P S A
Sbjct: 346 NLLQEMLLGGPCQAQEGRGWSGDSPGDR---PHTVSSPLSSLA 385
>gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo
sapiens]
Length = 417
Score = 181 bits (460), Expect = 1e-45
Identities = 117/370 (31%), Positives = 188/370 (50%), Gaps = 32/370 (8%)
Query: 102 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 161
LC +CGD A+G HYG +SC+ CK FF+R+++ N YSC + +C + K +R C+ CR
Sbjct: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
Query: 162 KCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEP 221
KC + GM KE V+ +R R RR E S S ++ LL AE
Sbjct: 119 KCFRAGMKKEAVQNERDRIS----TRRSSYEDSSLPS--------------INALLQAEV 160
Query: 222 DKLYAMPPPGMPEGDIKA-----LTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLL 276
P GDI+A + +C+ +L+V++ WAK+IP F L L DQ++LL
Sbjct: 161 LSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALL 220
Query: 277 QSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAIL-QLVRRYKKLK 335
++ E L+LG RS+ + D L+ DYI+ LA + + IL +LV +++L+
Sbjct: 221 RAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQ 280
Query: 336 VEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLT 395
++ E+ LKA+ + D+ + D +++L+ + +L+DY ++++ R G+LLL
Sbjct: 281 IDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLL 340
Query: 396 LPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEML-----EAKVGQEQLRGSPKDERMSSH 450
LP L+ + ++ +KL G + L EML +A+ G+ SP D H
Sbjct: 341 LPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPGDR---PH 397
Query: 451 DGKCPFQSAA 460
P S A
Sbjct: 398 TVSSPLSSLA 407
>gi|110611914 progesterone receptor [Homo sapiens]
Length = 933
Score = 178 bits (452), Expect = 9e-45
Identities = 92/283 (32%), Positives = 157/283 (55%), Gaps = 31/283 (10%)
Query: 92 EYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRR 151
+Y ++P+++CL+CGD ASG HYGV +C +CK FFKR ++G Y C N+C + K R
Sbjct: 556 QYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIR 615
Query: 152 RKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSES------------------ 193
RK+C ACR KC + GM+ G + + + + R LD+ +
Sbjct: 616 RKNCPACRLRKCCQAGMVLGGRKFKKF--NKVRVVRALDAVALPQPVGVPNESQALSQRF 673
Query: 194 --SPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADREL 251
SP +Q+ PP +++ L+ EPD +YA P+ LT+L L +R+L
Sbjct: 674 TFSPGQDIQLIPP-------LINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQL 726
Query: 252 VVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPY--DDKLVYAEDYIMDE 309
+ ++ W+K +PGF +L + DQ++L+Q +WM +++ G+ +RS + L +A D I++E
Sbjct: 727 LSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE 786
Query: 310 EHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANS 352
+ + + L + Q+ + + KL+V +EEF+ +K L L N+
Sbjct: 787 QRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNT 829
>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
Length = 445
Score = 176 bits (445), Expect = 6e-44
Identities = 108/387 (27%), Positives = 190/387 (49%), Gaps = 30/387 (7%)
Query: 102 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 161
LC +CGD A+G HYG +SC+ CK FF+R+I+ + YSC + +C + K +R C+ CR
Sbjct: 48 LCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLR 107
Query: 162 KCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEP 221
KC + GM KE V+ +R R + + D + P ++ + + S
Sbjct: 108 KCFRAGMKKEAVQNERDRISTR--RSTFDGSNIPSINTLAQAEVRSRQISVSS------- 158
Query: 222 DKLYAMPPPGMPEGDIKALTTL---CDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQS 278
P + ++K + ++ C+ ++L+V++ WAK+IP F L L DQ++LL++
Sbjct: 159 -------PGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRA 211
Query: 279 AWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEK 338
E L+LG RS+ Y D L+ +Y++ + R + +LVR +++++++
Sbjct: 212 HAGEHLLLGATKRSMMYKDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDD 271
Query: 339 EEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPL 398
E+ LKA+ + D+ + D ++ ++ + L+DY ++++ R G+LLL LP
Sbjct: 272 NEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPT 331
Query: 399 LRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCPFQS 458
L+ + ++ VKL G V + L EML +G GS M H + P
Sbjct: 332 LQSITWQMIEQIQFVKLFGMVKIDNLLQEML---LGGASNDGSHLHHPMHPHLSQDPLTG 388
Query: 459 --------AAFTSRDQSNSPGIPNPRP 477
+ DQ ++P P P P
Sbjct: 389 QTILLGPMSTLVHADQISTPETPLPSP 415
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,763,913
Number of Sequences: 37866
Number of extensions: 1119290
Number of successful extensions: 4839
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 132
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 4487
Number of HSP's gapped (non-prelim): 220
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.