Search of human proteins with 116063534

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo
sapiens]
         (1050 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]   2105   0.0  
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       169   1e-41
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        169   1e-41
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        169   1e-41
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       169   2e-41
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        169   2e-41
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        169   2e-41
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        169   2e-41
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        169   2e-41
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        166   1e-40
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   154   3e-37
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   145   1e-34
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   132   1e-30
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   131   3e-30
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    131   3e-30
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  130   6e-30
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   130   6e-30
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   129   2e-29
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   129   2e-29
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   129   2e-29
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   125   2e-28
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   124   5e-28
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   124   5e-28
gi|34304381 inversin isoform a [Homo sapiens]                         117   4e-26
gi|34304379 inversin isoform b [Homo sapiens]                         117   4e-26
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    106   1e-22
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   104   5e-22
gi|18079216 CASK interacting protein 1 [Homo sapiens]                 102   2e-21
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          100   6e-21
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...   100   9e-21

>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
          Length = 1050

 Score = 2105 bits (5453), Expect = 0.0
 Identities = 1050/1050 (100%), Positives = 1050/1050 (100%)

Query: 1    MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIP 60
            MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIP
Sbjct: 1    MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIP 60

Query: 61   VEEHFQTLNGKDVFIQGNRIKLGAGFACLLSVPILFEETFYNEKEESFSILCIAHPLEKR 120
            VEEHFQTLNGKDVFIQGNRIKLGAGFACLLSVPILFEETFYNEKEESFSILCIAHPLEKR
Sbjct: 61   VEEHFQTLNGKDVFIQGNRIKLGAGFACLLSVPILFEETFYNEKEESFSILCIAHPLEKR 120

Query: 121  ESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANA 180
            ESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANA
Sbjct: 121  ESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANA 180

Query: 181  LYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFN 240
            LYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFN
Sbjct: 181  LYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFN 240

Query: 241  KITRSLQDLQQKDIGVKPEFSFNIPRAKRELAQLNKCTSPQQKLVCLRKVVQLITQSPSQ 300
            KITRSLQDLQQKDIGVKPEFSFNIPRAKRELAQLNKCTSPQQKLVCLRKVVQLITQSPSQ
Sbjct: 241  KITRSLQDLQQKDIGVKPEFSFNIPRAKRELAQLNKCTSPQQKLVCLRKVVQLITQSPSQ 300

Query: 301  RVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIE 360
            RVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIE
Sbjct: 301  RVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIE 360

Query: 361  YIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQE 420
            YIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQE
Sbjct: 361  YIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQE 420

Query: 421  DHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLID 480
            DHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLID
Sbjct: 421  DHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLID 480

Query: 481  LLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYG 540
            LLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYG
Sbjct: 481  LLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYG 540

Query: 541  HEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKET 600
            HEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKET
Sbjct: 541  HEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKET 600

Query: 601  PLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQ 660
            PLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQ
Sbjct: 601  PLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQ 660

Query: 661  EETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKC 720
            EETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKC
Sbjct: 661  EETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKC 720

Query: 721  APAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVP 780
            APAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVP
Sbjct: 721  APAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVP 780

Query: 781  LHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASN 840
            LHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASN
Sbjct: 781  LHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASN 840

Query: 841  NKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCV 900
            NKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCV
Sbjct: 841  NKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCV 900

Query: 901  ASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARD 960
            ASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARD
Sbjct: 901  ASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARD 960

Query: 961  RSVPNLTEGSLHEPGRQSVTLRQNNLPAQSGSHAAEKGNSDWPERPGLTQTGPGHRRMLR 1020
            RSVPNLTEGSLHEPGRQSVTLRQNNLPAQSGSHAAEKGNSDWPERPGLTQTGPGHRRMLR
Sbjct: 961  RSVPNLTEGSLHEPGRQSVTLRQNNLPAQSGSHAAEKGNSDWPERPGLTQTGPGHRRMLR 1020

Query: 1021 RHTVEDAVVSQGPEAAGPLSTPQEVSASRS 1050
            RHTVEDAVVSQGPEAAGPLSTPQEVSASRS
Sbjct: 1021 RHTVEDAVVSQGPEAAGPLSTPQEVSASRS 1050


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  169 bits (429), Expect = 1e-41
 Identities = 149/505 (29%), Positives = 223/505 (44%), Gaps = 59/505 (11%)

Query: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
           T LHVAA CG   +  LL+ K A  NA   +G TPLH+AC+K    V  LL+ Y AS + 
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 405

Query: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
              +G TP+H+A   GH + V  L+         D+ N +G+T LH+AAR G   V+  L
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQ---NGASPDVTNIRGETALHMAARAGQVEVVRCL 462

Query: 585 LQNGASTEIQNRLKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAPV----QSPQR 637
           L+NGA  + + R ++TPL  A     ++I+ ++  +    +    +   P+    +  Q 
Sbjct: 463 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 522

Query: 638 SVDSISQESST--SSFSSMSASSRQEETKKDYREVEKLL---RAVADG------------ 680
            V S+  E+    S  +    +      K    +V KLL   RA AD             
Sbjct: 523 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 582

Query: 681 ---DLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS---- 733
              D + V  LL      LE        A P         P    A+K   ++ ++    
Sbjct: 583 AHYDNQKVALLL------LE------KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 630

Query: 734 GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVV 793
           G   N+ ++ G +PLH+A+  G  D++ LLL  GAN           LHLA Q+    V 
Sbjct: 631 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 690

Query: 794 KCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIE 853
             L    A  +     G TPLI AC  G+ ++V  LL+ GA++NA    G T LH+A  +
Sbjct: 691 DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQ 750

Query: 854 KHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKE 913
            H  ++ +LL HGA          TA+  A++   I        S V +L  V E     
Sbjct: 751 GHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYI--------SVVDTLKVVTEEVTTT 802

Query: 914 YVTVKIRKKWN-----SKLYDLPDE 933
             T+  + K N     +++ D+ DE
Sbjct: 803 TTTITEKHKLNVPETMTEVLDVSDE 827



 Score =  152 bits (384), Expect = 2e-36
 Identities = 123/433 (28%), Positives = 197/433 (45%), Gaps = 48/433 (11%)

Query: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLH 517
           S   +G+T LH+A++ GQA ++ +LV +GA +NA   +G TPL++A Q+ +  V   LL 
Sbjct: 71  SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130

Query: 518 YKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTP-LHIAARWG 576
             A+      +G TPL +A   GH   V  L+  D +         K   P LHIAAR  
Sbjct: 131 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKG--------KVRLPALHIAARKD 182

Query: 577 YQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQ 636
                  LLQN  + ++Q+++        +N    S     H++      +    + +  
Sbjct: 183 DTKSAALLLQNDHNADVQSKMM-------VNRTTESGFTPLHIAAHYGNVNVATLLLNRG 235

Query: 637 RSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDL 696
            +VD  ++   T     +  +S++                   G+  MV+ LL       
Sbjct: 236 AAVDFTARNGITP----LHVASKR-------------------GNTNMVKLLL------- 265

Query: 697 EDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGR 756
            D    + A   +   PL  C   +   + +  +   G  +   +++G SPLH+AA    
Sbjct: 266 -DRGGQIDAKTRDGLTPL-HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 323

Query: 757 ADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIY 816
            + +  LL+H A       D    LH+A   GH++V K LLD  A PN + L+G TPL  
Sbjct: 324 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 383

Query: 817 ACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876
           AC     +++ LL+++GASI A    G T +H A    H+ +V LLL +GAS  V N R 
Sbjct: 384 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 443

Query: 877 RTAVDCAEQNSKI 889
            TA+  A +  ++
Sbjct: 444 ETALHMAARAGQV 456



 Score =  149 bits (377), Expect = 1e-35
 Identities = 122/458 (26%), Positives = 196/458 (42%), Gaps = 68/458 (14%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           RG T LH+AA  GQ  ++  L+  GA+V+A      TPLH+A + G   +  LLL + A 
Sbjct: 442 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 501

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
            +    NG TPLH++   G  D    L+          +  +KG TPLH+AA++G   V 
Sbjct: 502 PDAATTNGYTPLHISAREGQVDVASVLL---EAGAAHSLATKKGFTPLHVAAKYGSLDVA 558

Query: 582 ETLLQNGASTEIQNRLKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAPVQSPQRS 638
           + LLQ  A+ +   +   TPL  A    N K+  ++     S     K+   P+      
Sbjct: 559 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH----- 613

Query: 639 VDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLED 698
              I+ + +    +S   +   E      + V  L  A  +G  +MV  LL+        
Sbjct: 614 ---IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-------- 662

Query: 699 AEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRAD 758
                                              G  ++++++ G + LH+AA   + +
Sbjct: 663 ----------------------------------KGANIHMSTKSGLTSLHLAAQEDKVN 688

Query: 759 LIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYAC 818
           +  +L KHGA+  A       PL +AC  G+ ++V  LL   A  N K  +G TPL  A 
Sbjct: 689 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 748

Query: 819 SGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRT 878
             GH  ++ +LLQHGA  NA+   GNTAL  A    ++ VV+ L       +V+ +   T
Sbjct: 749 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL-------KVVTEEVTT 801

Query: 879 AVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKEYVT 916
                 +  K+      VP  +  + DV++ +  + +T
Sbjct: 802 TTTTITEKHKLN-----VPETMTEVLDVSDEEGDDTMT 834



 Score =  130 bits (326), Expect = 8e-30
 Identities = 116/429 (27%), Positives = 180/429 (41%), Gaps = 54/429 (12%)

Query: 470 AAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNG 529
           AA  G    +   +  G  +N  + +G   LHLA ++G+  +   LL   +S +     G
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76

Query: 530 NTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGA 589
           NT LH+A   G  + VK LV    E   ++  ++ G TPL++AA+  +  V++ LL+NGA
Sbjct: 77  NTALHIASLAGQAEVVKVLVK---EGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 133

Query: 590 STEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTS 649
           +         TPL  AL                          Q       +I  E+ T 
Sbjct: 134 NQSTATEDGFTPLAVAL--------------------------QQGHNQAVAILLENDTK 167

Query: 650 S---FSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAA 706
                 ++  ++R+++TK        LL+   + D++    +   TE             
Sbjct: 168 GKVRLPALHIAARKDDTKS----AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 223

Query: 707 DPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKH 766
           +      L                   G  V+ T+++G +PLHVA+  G  +++ LLL  
Sbjct: 224 NVNVATLLLN----------------RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 267

Query: 767 GANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELV 826
           G    A+  D   PLH A + GH QVV+ LL+  A    +  +G +PL  A  G H E V
Sbjct: 268 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 327

Query: 827 ALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGA--SVQVLNKRQRTAVDCAE 884
             LLQH A ++       TALH A    H  V +LLL   A  + + LN      + C +
Sbjct: 328 KHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 387

Query: 885 QNSKIMELL 893
              K+MELL
Sbjct: 388 NRIKVMELL 396



 Score =  105 bits (261), Expect = 3e-22
 Identities = 94/348 (27%), Positives = 143/348 (41%), Gaps = 64/348 (18%)

Query: 456 PFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLL 515
           P +    G+TPLH++A  GQ  +  +L+  GA  +     G TPLH+A + G   V  LL
Sbjct: 502 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 561

Query: 516 LHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARW 575
           L  +A+A+    NG TPLH+A  Y ++     L+    +        + G TPLHIAA+ 
Sbjct: 562 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL---EKGASPHATAKNGYTPLHIAAKK 618

Query: 576 GYQGVIETLLQNGASTEIQNRLKETPLKCA-------LNSKILSVMEAYHLSFERRQKSS 628
               +  TLL  GA T I  +   TPL  A       + + +L      H+S +    S 
Sbjct: 619 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 678

Query: 629 EAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYL 688
               Q  + +V  I          +   + +   TK  Y     L+ A   G+++MV +L
Sbjct: 679 HLAAQEDKVNVADI---------LTKHGADQDAHTKLGY---TPLIVACHYGNVKMVNFL 726

Query: 689 LEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPL 748
           L+                                           G  VN  +++G +PL
Sbjct: 727 LK------------------------------------------QGANVNAKTKNGYTPL 744

Query: 749 HVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           H AA  G   +I +LL+HGA   A  A+    L +A + G+  VV  L
Sbjct: 745 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 49/148 (33%), Positives = 71/148 (47%), Gaps = 3/148 (2%)

Query: 455 TPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLL 514
           +P +    G+TPLH+AA   Q  +   L++ GA  N     G TPLHLA Q+G+  +  L
Sbjct: 600 SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTL 659

Query: 515 LLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAAR 574
           LL   A+  +   +G T LHLA     ED V             D   + G TPL +A  
Sbjct: 660 LLDKGANIHMSTKSGLTSLHLA---AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 716

Query: 575 WGYQGVIETLLQNGASTEIQNRLKETPL 602
           +G   ++  LL+ GA+   + +   TPL
Sbjct: 717 YGNVKMVNFLLKQGANVNAKTKNGYTPL 744



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 87/363 (23%), Positives = 137/363 (37%), Gaps = 65/363 (17%)

Query: 552 DVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKIL 611
           D+ +C     N+ G   LH+AA+ G+ G+++ LL  G+S +   +   T L         
Sbjct: 35  DINTC-----NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTAL--------- 80

Query: 612 SVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVE 671
                 H++    Q      +     ++++ SQ   T                       
Sbjct: 81  ------HIASLAGQAEVVKVLVKEGANINAQSQNGFTP---------------------- 112

Query: 672 KLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVP 731
            L  A  +  +++V+YLLE         ED  +             P     Q+   +  
Sbjct: 113 -LYMAAQENHIDVVKYLLENGANQSTATEDGFT-------------PLAVALQQGHNQAV 158

Query: 732 ASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQA--------VPLHL 783
           A  L  +   +     LH+AA         LLL++  NA  ++             PLH+
Sbjct: 159 AILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 218

Query: 784 ACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKG 843
           A   G+  V   LL+  A  +    +G TPL  A   G+  +V LLL  G  I+A    G
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278

Query: 844 NTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASL 903
            T LH A    H  VVELLL  GA +    K   + +  A Q   + E ++ +    A +
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV-ECVKHLLQHKAPV 337

Query: 904 DDV 906
           DDV
Sbjct: 338 DDV 340



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 44/126 (34%), Positives = 66/126 (52%)

Query: 743 DGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAK 802
           D ++    AA  G  D +   LK G +    N +    LHLA ++GH  +V+ LL   + 
Sbjct: 9   DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68

Query: 803 PNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELL 862
            +     GNT L  A   G  E+V +L++ GA+INA +  G T L+ A  E H+ VV+ L
Sbjct: 69  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128

Query: 863 LLHGAS 868
           L +GA+
Sbjct: 129 LENGAN 134



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 58/209 (27%), Positives = 92/209 (44%), Gaps = 14/209 (6%)

Query: 311 DLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIEYI-RQGSLSA 369
           D   V L LL K   P+  A   Y      +   + ++   L ++ A    + +QG    
Sbjct: 586 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 645

Query: 370 KPPESEGFGDRL-FLKQRMSLLSQMTSSPTDCLFKHIASGNQK-EVERLLSQEDHDKDTV 427
                EG  D +  L  + + +   T S    L  H+A+   K  V  +L++   D+D  
Sbjct: 646 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL--HLAAQEDKVNVADILTKHGADQDAH 703

Query: 428 QKMCH-PLCFCDDCE----KLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLL 482
            K+ + PL     C     K+V+  L   + V   ++   G+TPLH AA  G   +I++L
Sbjct: 704 TKLGYTPLIVA--CHYGNVKMVNFLLKQGANVN--AKTKNGYTPLHQAAQQGHTHIINVL 759

Query: 483 VSKGAMVNATDYHGATPLHLACQKGYQSV 511
           +  GA  NAT  +G T L +A + GY SV
Sbjct: 760 LQHGAKPNATTANGNTALAIAKRLGYISV 788



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 27/73 (36%), Positives = 36/73 (49%)

Query: 811 NTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQ 870
           N   + A   G+ + V   L+ G  IN  N  G  ALH A  E HV +V+ LL  G+SV 
Sbjct: 11  NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 70

Query: 871 VLNKRQRTAVDCA 883
              K+  TA+  A
Sbjct: 71  SATKKGNTALHIA 83


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  169 bits (429), Expect = 1e-41
 Identities = 149/505 (29%), Positives = 223/505 (44%), Gaps = 59/505 (11%)

Query: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
           T LHVAA CG   +  LL+ K A  NA   +G TPLH+AC+K    V  LL+ Y AS + 
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
              +G TP+H+A   GH + V  L+         D+ N +G+T LH+AAR G   V+  L
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQ---NGASPDVTNIRGETALHMAARAGQVEVVRCL 483

Query: 585 LQNGASTEIQNRLKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAPV----QSPQR 637
           L+NGA  + + R ++TPL  A     ++I+ ++  +    +    +   P+    +  Q 
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543

Query: 638 SVDSISQESST--SSFSSMSASSRQEETKKDYREVEKLL---RAVADG------------ 680
            V S+  E+    S  +    +      K    +V KLL   RA AD             
Sbjct: 544 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603

Query: 681 ---DLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS---- 733
              D + V  LL      LE        A P         P    A+K   ++ ++    
Sbjct: 604 AHYDNQKVALLL------LE------KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651

Query: 734 GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVV 793
           G   N+ ++ G +PLH+A+  G  D++ LLL  GAN           LHLA Q+    V 
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 711

Query: 794 KCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIE 853
             L    A  +     G TPLI AC  G+ ++V  LL+ GA++NA    G T LH+A  +
Sbjct: 712 DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQ 771

Query: 854 KHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKE 913
            H  ++ +LL HGA          TA+  A++   I        S V +L  V E     
Sbjct: 772 GHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYI--------SVVDTLKVVTEEVTTT 823

Query: 914 YVTVKIRKKWN-----SKLYDLPDE 933
             T+  + K N     +++ D+ DE
Sbjct: 824 TTTITEKHKLNVPETMTEVLDVSDE 848



 Score =  152 bits (384), Expect = 2e-36
 Identities = 123/433 (28%), Positives = 197/433 (45%), Gaps = 48/433 (11%)

Query: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLH 517
           S   +G+T LH+A++ GQA ++ +LV +GA +NA   +G TPL++A Q+ +  V   LL 
Sbjct: 92  SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 518 YKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTP-LHIAARWG 576
             A+      +G TPL +A   GH   V  L+  D +         K   P LHIAAR  
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKG--------KVRLPALHIAARKD 203

Query: 577 YQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQ 636
                  LLQN  + ++Q+++        +N    S     H++      +    + +  
Sbjct: 204 DTKSAALLLQNDHNADVQSKMM-------VNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256

Query: 637 RSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDL 696
            +VD  ++   T     +  +S++                   G+  MV+ LL       
Sbjct: 257 AAVDFTARNGITP----LHVASKR-------------------GNTNMVKLLL------- 286

Query: 697 EDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGR 756
            D    + A   +   PL  C   +   + +  +   G  +   +++G SPLH+AA    
Sbjct: 287 -DRGGQIDAKTRDGLTPL-HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 344

Query: 757 ADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIY 816
            + +  LL+H A       D    LH+A   GH++V K LLD  A PN + L+G TPL  
Sbjct: 345 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 404

Query: 817 ACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876
           AC     +++ LL+++GASI A    G T +H A    H+ +V LLL +GAS  V N R 
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 464

Query: 877 RTAVDCAEQNSKI 889
            TA+  A +  ++
Sbjct: 465 ETALHMAARAGQV 477



 Score =  149 bits (377), Expect = 1e-35
 Identities = 122/458 (26%), Positives = 196/458 (42%), Gaps = 68/458 (14%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           RG T LH+AA  GQ  ++  L+  GA+V+A      TPLH+A + G   +  LLL + A 
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
            +    NG TPLH++   G  D    L+          +  +KG TPLH+AA++G   V 
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLL---EAGAAHSLATKKGFTPLHVAAKYGSLDVA 579

Query: 582 ETLLQNGASTEIQNRLKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAPVQSPQRS 638
           + LLQ  A+ +   +   TPL  A    N K+  ++     S     K+   P+      
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH----- 634

Query: 639 VDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLED 698
              I+ + +    +S   +   E      + V  L  A  +G  +MV  LL+        
Sbjct: 635 ---IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-------- 683

Query: 699 AEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRAD 758
                                              G  ++++++ G + LH+AA   + +
Sbjct: 684 ----------------------------------KGANIHMSTKSGLTSLHLAAQEDKVN 709

Query: 759 LIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYAC 818
           +  +L KHGA+  A       PL +AC  G+ ++V  LL   A  N K  +G TPL  A 
Sbjct: 710 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769

Query: 819 SGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRT 878
             GH  ++ +LLQHGA  NA+   GNTAL  A    ++ VV+ L       +V+ +   T
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL-------KVVTEEVTT 822

Query: 879 AVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKEYVT 916
                 +  K+      VP  +  + DV++ +  + +T
Sbjct: 823 TTTTITEKHKLN-----VPETMTEVLDVSDEEGDDTMT 855



 Score =  130 bits (326), Expect = 8e-30
 Identities = 116/429 (27%), Positives = 180/429 (41%), Gaps = 54/429 (12%)

Query: 470 AAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNG 529
           AA  G    +   +  G  +N  + +G   LHLA ++G+  +   LL   +S +     G
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 530 NTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGA 589
           NT LH+A   G  + VK LV    E   ++  ++ G TPL++AA+  +  V++ LL+NGA
Sbjct: 98  NTALHIASLAGQAEVVKVLVK---EGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154

Query: 590 STEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTS 649
           +         TPL  AL                          Q       +I  E+ T 
Sbjct: 155 NQSTATEDGFTPLAVAL--------------------------QQGHNQAVAILLENDTK 188

Query: 650 S---FSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAA 706
                 ++  ++R+++TK        LL+   + D++    +   TE             
Sbjct: 189 GKVRLPALHIAARKDDTKS----AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 244

Query: 707 DPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKH 766
           +      L                   G  V+ T+++G +PLHVA+  G  +++ LLL  
Sbjct: 245 NVNVATLLLN----------------RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288

Query: 767 GANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELV 826
           G    A+  D   PLH A + GH QVV+ LL+  A    +  +G +PL  A  G H E V
Sbjct: 289 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 348

Query: 827 ALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGA--SVQVLNKRQRTAVDCAE 884
             LLQH A ++       TALH A    H  V +LLL   A  + + LN      + C +
Sbjct: 349 KHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 408

Query: 885 QNSKIMELL 893
              K+MELL
Sbjct: 409 NRIKVMELL 417



 Score =  105 bits (261), Expect = 3e-22
 Identities = 94/348 (27%), Positives = 143/348 (41%), Gaps = 64/348 (18%)

Query: 456 PFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLL 515
           P +    G+TPLH++A  GQ  +  +L+  GA  +     G TPLH+A + G   V  LL
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582

Query: 516 LHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARW 575
           L  +A+A+    NG TPLH+A  Y ++     L+    +        + G TPLHIAA+ 
Sbjct: 583 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL---EKGASPHATAKNGYTPLHIAAKK 639

Query: 576 GYQGVIETLLQNGASTEIQNRLKETPLKCA-------LNSKILSVMEAYHLSFERRQKSS 628
               +  TLL  GA T I  +   TPL  A       + + +L      H+S +    S 
Sbjct: 640 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699

Query: 629 EAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYL 688
               Q  + +V  I          +   + +   TK  Y     L+ A   G+++MV +L
Sbjct: 700 HLAAQEDKVNVADI---------LTKHGADQDAHTKLGY---TPLIVACHYGNVKMVNFL 747

Query: 689 LEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPL 748
           L+                                           G  VN  +++G +PL
Sbjct: 748 LK------------------------------------------QGANVNAKTKNGYTPL 765

Query: 749 HVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           H AA  G   +I +LL+HGA   A  A+    L +A + G+  VV  L
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 49/148 (33%), Positives = 71/148 (47%), Gaps = 3/148 (2%)

Query: 455 TPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLL 514
           +P +    G+TPLH+AA   Q  +   L++ GA  N     G TPLHLA Q+G+  +  L
Sbjct: 621 SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTL 680

Query: 515 LLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAAR 574
           LL   A+  +   +G T LHLA     ED V             D   + G TPL +A  
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLA---AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 737

Query: 575 WGYQGVIETLLQNGASTEIQNRLKETPL 602
           +G   ++  LL+ GA+   + +   TPL
Sbjct: 738 YGNVKMVNFLLKQGANVNAKTKNGYTPL 765



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 87/363 (23%), Positives = 137/363 (37%), Gaps = 65/363 (17%)

Query: 552 DVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKIL 611
           D+ +C     N+ G   LH+AA+ G+ G+++ LL  G+S +   +   T L         
Sbjct: 56  DINTC-----NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTAL--------- 101

Query: 612 SVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVE 671
                 H++    Q      +     ++++ SQ   T                       
Sbjct: 102 ------HIASLAGQAEVVKVLVKEGANINAQSQNGFTP---------------------- 133

Query: 672 KLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVP 731
            L  A  +  +++V+YLLE         ED  +             P     Q+   +  
Sbjct: 134 -LYMAAQENHIDVVKYLLENGANQSTATEDGFT-------------PLAVALQQGHNQAV 179

Query: 732 ASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQA--------VPLHL 783
           A  L  +   +     LH+AA         LLL++  NA  ++             PLH+
Sbjct: 180 AILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239

Query: 784 ACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKG 843
           A   G+  V   LL+  A  +    +G TPL  A   G+  +V LLL  G  I+A    G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299

Query: 844 NTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASL 903
            T LH A    H  VVELLL  GA +    K   + +  A Q   + E ++ +    A +
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV-ECVKHLLQHKAPV 358

Query: 904 DDV 906
           DDV
Sbjct: 359 DDV 361



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 44/126 (34%), Positives = 66/126 (52%)

Query: 743 DGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAK 802
           D ++    AA  G  D +   LK G +    N +    LHLA ++GH  +V+ LL   + 
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 803 PNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELL 862
            +     GNT L  A   G  E+V +L++ GA+INA +  G T L+ A  E H+ VV+ L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 863 LLHGAS 868
           L +GA+
Sbjct: 150 LENGAN 155



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 34/117 (29%), Positives = 55/117 (47%)

Query: 773 RNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQH 832
           + +D       A + G+   V   L      N  + +G   L  A   GH  LV  LL  
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 833 GASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKI 889
           G+S++++  KGNTALH A +     VV++L+  GA++   ++   T +  A Q + I
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 58/209 (27%), Positives = 92/209 (44%), Gaps = 14/209 (6%)

Query: 311 DLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIEYI-RQGSLSA 369
           D   V L LL K   P+  A   Y      +   + ++   L ++ A    + +QG    
Sbjct: 607 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666

Query: 370 KPPESEGFGDRL-FLKQRMSLLSQMTSSPTDCLFKHIASGNQK-EVERLLSQEDHDKDTV 427
                EG  D +  L  + + +   T S    L  H+A+   K  V  +L++   D+D  
Sbjct: 667 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL--HLAAQEDKVNVADILTKHGADQDAH 724

Query: 428 QKMCH-PLCFCDDCE----KLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLL 482
            K+ + PL     C     K+V+  L   + V   ++   G+TPLH AA  G   +I++L
Sbjct: 725 TKLGYTPLIVA--CHYGNVKMVNFLLKQGANVN--AKTKNGYTPLHQAAQQGHTHIINVL 780

Query: 483 VSKGAMVNATDYHGATPLHLACQKGYQSV 511
           +  GA  NAT  +G T L +A + GY SV
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGYISV 809



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 30/82 (36%), Positives = 40/82 (48%), Gaps = 2/82 (2%)

Query: 802 KPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVEL 861
           +P K D   N   + A   G+ + V   L+ G  IN  N  G  ALH A  E HV +V+ 
Sbjct: 25  RPKKSD--SNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE 82

Query: 862 LLLHGASVQVLNKRQRTAVDCA 883
           LL  G+SV    K+  TA+  A
Sbjct: 83  LLGRGSSVDSATKKGNTALHIA 104


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  169 bits (429), Expect = 1e-41
 Identities = 149/505 (29%), Positives = 223/505 (44%), Gaps = 59/505 (11%)

Query: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
           T LHVAA CG   +  LL+ K A  NA   +G TPLH+AC+K    V  LL+ Y AS + 
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
              +G TP+H+A   GH + V  L+         D+ N +G+T LH+AAR G   V+  L
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQ---NGASPDVTNIRGETALHMAARAGQVEVVRCL 483

Query: 585 LQNGASTEIQNRLKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAPV----QSPQR 637
           L+NGA  + + R ++TPL  A     ++I+ ++  +    +    +   P+    +  Q 
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543

Query: 638 SVDSISQESST--SSFSSMSASSRQEETKKDYREVEKLL---RAVADG------------ 680
            V S+  E+    S  +    +      K    +V KLL   RA AD             
Sbjct: 544 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603

Query: 681 ---DLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS---- 733
              D + V  LL      LE        A P         P    A+K   ++ ++    
Sbjct: 604 AHYDNQKVALLL------LE------KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651

Query: 734 GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVV 793
           G   N+ ++ G +PLH+A+  G  D++ LLL  GAN           LHLA Q+    V 
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 711

Query: 794 KCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIE 853
             L    A  +     G TPLI AC  G+ ++V  LL+ GA++NA    G T LH+A  +
Sbjct: 712 DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQ 771

Query: 854 KHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKE 913
            H  ++ +LL HGA          TA+  A++   I        S V +L  V E     
Sbjct: 772 GHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYI--------SVVDTLKVVTEEVTTT 823

Query: 914 YVTVKIRKKWN-----SKLYDLPDE 933
             T+  + K N     +++ D+ DE
Sbjct: 824 TTTITEKHKLNVPETMTEVLDVSDE 848



 Score =  152 bits (384), Expect = 2e-36
 Identities = 123/433 (28%), Positives = 197/433 (45%), Gaps = 48/433 (11%)

Query: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLH 517
           S   +G+T LH+A++ GQA ++ +LV +GA +NA   +G TPL++A Q+ +  V   LL 
Sbjct: 92  SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 518 YKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTP-LHIAARWG 576
             A+      +G TPL +A   GH   V  L+  D +         K   P LHIAAR  
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKG--------KVRLPALHIAARKD 203

Query: 577 YQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQ 636
                  LLQN  + ++Q+++        +N    S     H++      +    + +  
Sbjct: 204 DTKSAALLLQNDHNADVQSKMM-------VNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256

Query: 637 RSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDL 696
            +VD  ++   T     +  +S++                   G+  MV+ LL       
Sbjct: 257 AAVDFTARNGITP----LHVASKR-------------------GNTNMVKLLL------- 286

Query: 697 EDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGR 756
            D    + A   +   PL  C   +   + +  +   G  +   +++G SPLH+AA    
Sbjct: 287 -DRGGQIDAKTRDGLTPL-HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 344

Query: 757 ADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIY 816
            + +  LL+H A       D    LH+A   GH++V K LLD  A PN + L+G TPL  
Sbjct: 345 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 404

Query: 817 ACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876
           AC     +++ LL+++GASI A    G T +H A    H+ +V LLL +GAS  V N R 
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 464

Query: 877 RTAVDCAEQNSKI 889
            TA+  A +  ++
Sbjct: 465 ETALHMAARAGQV 477



 Score =  149 bits (377), Expect = 1e-35
 Identities = 122/458 (26%), Positives = 196/458 (42%), Gaps = 68/458 (14%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           RG T LH+AA  GQ  ++  L+  GA+V+A      TPLH+A + G   +  LLL + A 
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
            +    NG TPLH++   G  D    L+          +  +KG TPLH+AA++G   V 
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLL---EAGAAHSLATKKGFTPLHVAAKYGSLDVA 579

Query: 582 ETLLQNGASTEIQNRLKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAPVQSPQRS 638
           + LLQ  A+ +   +   TPL  A    N K+  ++     S     K+   P+      
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH----- 634

Query: 639 VDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLED 698
              I+ + +    +S   +   E      + V  L  A  +G  +MV  LL+        
Sbjct: 635 ---IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-------- 683

Query: 699 AEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRAD 758
                                              G  ++++++ G + LH+AA   + +
Sbjct: 684 ----------------------------------KGANIHMSTKSGLTSLHLAAQEDKVN 709

Query: 759 LIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYAC 818
           +  +L KHGA+  A       PL +AC  G+ ++V  LL   A  N K  +G TPL  A 
Sbjct: 710 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769

Query: 819 SGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRT 878
             GH  ++ +LLQHGA  NA+   GNTAL  A    ++ VV+ L       +V+ +   T
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL-------KVVTEEVTT 822

Query: 879 AVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKEYVT 916
                 +  K+      VP  +  + DV++ +  + +T
Sbjct: 823 TTTTITEKHKLN-----VPETMTEVLDVSDEEGDDTMT 855



 Score =  130 bits (326), Expect = 8e-30
 Identities = 116/429 (27%), Positives = 180/429 (41%), Gaps = 54/429 (12%)

Query: 470 AAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNG 529
           AA  G    +   +  G  +N  + +G   LHLA ++G+  +   LL   +S +     G
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 530 NTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGA 589
           NT LH+A   G  + VK LV    E   ++  ++ G TPL++AA+  +  V++ LL+NGA
Sbjct: 98  NTALHIASLAGQAEVVKVLVK---EGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154

Query: 590 STEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTS 649
           +         TPL  AL                          Q       +I  E+ T 
Sbjct: 155 NQSTATEDGFTPLAVAL--------------------------QQGHNQAVAILLENDTK 188

Query: 650 S---FSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAA 706
                 ++  ++R+++TK        LL+   + D++    +   TE             
Sbjct: 189 GKVRLPALHIAARKDDTKS----AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 244

Query: 707 DPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKH 766
           +      L                   G  V+ T+++G +PLHVA+  G  +++ LLL  
Sbjct: 245 NVNVATLLLN----------------RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288

Query: 767 GANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELV 826
           G    A+  D   PLH A + GH QVV+ LL+  A    +  +G +PL  A  G H E V
Sbjct: 289 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 348

Query: 827 ALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGA--SVQVLNKRQRTAVDCAE 884
             LLQH A ++       TALH A    H  V +LLL   A  + + LN      + C +
Sbjct: 349 KHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 408

Query: 885 QNSKIMELL 893
              K+MELL
Sbjct: 409 NRIKVMELL 417



 Score =  105 bits (261), Expect = 3e-22
 Identities = 94/348 (27%), Positives = 143/348 (41%), Gaps = 64/348 (18%)

Query: 456 PFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLL 515
           P +    G+TPLH++A  GQ  +  +L+  GA  +     G TPLH+A + G   V  LL
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582

Query: 516 LHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARW 575
           L  +A+A+    NG TPLH+A  Y ++     L+    +        + G TPLHIAA+ 
Sbjct: 583 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL---EKGASPHATAKNGYTPLHIAAKK 639

Query: 576 GYQGVIETLLQNGASTEIQNRLKETPLKCA-------LNSKILSVMEAYHLSFERRQKSS 628
               +  TLL  GA T I  +   TPL  A       + + +L      H+S +    S 
Sbjct: 640 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699

Query: 629 EAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYL 688
               Q  + +V  I          +   + +   TK  Y     L+ A   G+++MV +L
Sbjct: 700 HLAAQEDKVNVADI---------LTKHGADQDAHTKLGY---TPLIVACHYGNVKMVNFL 747

Query: 689 LEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPL 748
           L+                                           G  VN  +++G +PL
Sbjct: 748 LK------------------------------------------QGANVNAKTKNGYTPL 765

Query: 749 HVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           H AA  G   +I +LL+HGA   A  A+    L +A + G+  VV  L
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 49/148 (33%), Positives = 71/148 (47%), Gaps = 3/148 (2%)

Query: 455 TPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLL 514
           +P +    G+TPLH+AA   Q  +   L++ GA  N     G TPLHLA Q+G+  +  L
Sbjct: 621 SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTL 680

Query: 515 LLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAAR 574
           LL   A+  +   +G T LHLA     ED V             D   + G TPL +A  
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLA---AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 737

Query: 575 WGYQGVIETLLQNGASTEIQNRLKETPL 602
           +G   ++  LL+ GA+   + +   TPL
Sbjct: 738 YGNVKMVNFLLKQGANVNAKTKNGYTPL 765



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 87/363 (23%), Positives = 137/363 (37%), Gaps = 65/363 (17%)

Query: 552 DVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKIL 611
           D+ +C     N+ G   LH+AA+ G+ G+++ LL  G+S +   +   T L         
Sbjct: 56  DINTC-----NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTAL--------- 101

Query: 612 SVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVE 671
                 H++    Q      +     ++++ SQ   T                       
Sbjct: 102 ------HIASLAGQAEVVKVLVKEGANINAQSQNGFTP---------------------- 133

Query: 672 KLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVP 731
            L  A  +  +++V+YLLE         ED  +             P     Q+   +  
Sbjct: 134 -LYMAAQENHIDVVKYLLENGANQSTATEDGFT-------------PLAVALQQGHNQAV 179

Query: 732 ASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQA--------VPLHL 783
           A  L  +   +     LH+AA         LLL++  NA  ++             PLH+
Sbjct: 180 AILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239

Query: 784 ACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKG 843
           A   G+  V   LL+  A  +    +G TPL  A   G+  +V LLL  G  I+A    G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299

Query: 844 NTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASL 903
            T LH A    H  VVELLL  GA +    K   + +  A Q   + E ++ +    A +
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV-ECVKHLLQHKAPV 358

Query: 904 DDV 906
           DDV
Sbjct: 359 DDV 361



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 44/126 (34%), Positives = 66/126 (52%)

Query: 743 DGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAK 802
           D ++    AA  G  D +   LK G +    N +    LHLA ++GH  +V+ LL   + 
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 803 PNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELL 862
            +     GNT L  A   G  E+V +L++ GA+INA +  G T L+ A  E H+ VV+ L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 863 LLHGAS 868
           L +GA+
Sbjct: 150 LENGAN 155



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 34/117 (29%), Positives = 55/117 (47%)

Query: 773 RNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQH 832
           + +D       A + G+   V   L      N  + +G   L  A   GH  LV  LL  
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 833 GASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKI 889
           G+S++++  KGNTALH A +     VV++L+  GA++   ++   T +  A Q + I
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 58/209 (27%), Positives = 92/209 (44%), Gaps = 14/209 (6%)

Query: 311 DLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIEYI-RQGSLSA 369
           D   V L LL K   P+  A   Y      +   + ++   L ++ A    + +QG    
Sbjct: 607 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666

Query: 370 KPPESEGFGDRL-FLKQRMSLLSQMTSSPTDCLFKHIASGNQK-EVERLLSQEDHDKDTV 427
                EG  D +  L  + + +   T S    L  H+A+   K  V  +L++   D+D  
Sbjct: 667 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL--HLAAQEDKVNVADILTKHGADQDAH 724

Query: 428 QKMCH-PLCFCDDCE----KLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLL 482
            K+ + PL     C     K+V+  L   + V   ++   G+TPLH AA  G   +I++L
Sbjct: 725 TKLGYTPLIVA--CHYGNVKMVNFLLKQGANVN--AKTKNGYTPLHQAAQQGHTHIINVL 780

Query: 483 VSKGAMVNATDYHGATPLHLACQKGYQSV 511
           +  GA  NAT  +G T L +A + GY SV
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGYISV 809



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 30/82 (36%), Positives = 40/82 (48%), Gaps = 2/82 (2%)

Query: 802 KPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVEL 861
           +P K D   N   + A   G+ + V   L+ G  IN  N  G  ALH A  E HV +V+ 
Sbjct: 25  RPKKSD--SNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE 82

Query: 862 LLLHGASVQVLNKRQRTAVDCA 883
           LL  G+SV    K+  TA+  A
Sbjct: 83  LLGRGSSVDSATKKGNTALHIA 104


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  169 bits (427), Expect = 2e-41
 Identities = 133/431 (30%), Positives = 196/431 (45%), Gaps = 52/431 (12%)

Query: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
           TPLHVAA CG   +  +L+ KGA  N+   +G TPLH+AC+K +  V  LLL   AS + 
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432

Query: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
              +G TPLH+A   GH   VK L+         ++ N K +TPLH+AAR G+  V + L
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASP---NVSNVKVETPLHMAARAGHTEVAKYL 489

Query: 585 LQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQ 644
           LQN A    + +  +TPL CA      ++++   L  E     + A              
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVK---LLLENNANPNLA-------------- 532

Query: 645 ESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVS 704
             +T+  + +  ++R+                   G +E V  LLE   ++   A  T  
Sbjct: 533 --TTAGHTPLHIAARE-------------------GHVETVLALLE---KEASQACMTKK 568

Query: 705 AADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLL 764
              P   H   +  K   A+  L +        N   ++G +PLHVA  H   D++ LLL
Sbjct: 569 GFTP--LHVAAKYGKVRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622

Query: 765 KHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHE 824
             G +  +   +   PLH+A +Q   +V + LL      N + + G TPL  A   GH E
Sbjct: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682

Query: 825 LVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAE 884
           +VALLL   A+ N  N  G T LH    E HV V ++L+ HG  V    +   T +  A 
Sbjct: 683 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742

Query: 885 Q--NSKIMELL 893
              N K+++ L
Sbjct: 743 HYGNIKLVKFL 753



 Score =  159 bits (403), Expect = 1e-38
 Identities = 143/541 (26%), Positives = 231/541 (42%), Gaps = 55/541 (10%)

Query: 406 ASGNQKEVERLLSQEDHDKDTVQKMCH--PLCFCDDCEKLVSGRLNDPSVVTPFSRDDRG 463
           A G+  +  RLL Q D + D +  + H  PL     C      ++       P SR   G
Sbjct: 346 AQGDHLDCVRLLLQYDAEIDDIT-LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 404

Query: 464 HTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAE 523
            TPLH+A       +++LL+  GA ++A    G TPLH+A   G+  +   LL   AS  
Sbjct: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464

Query: 524 VQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIET 583
           V +    TPLH+A   GH +  K L+       +++   +   TPLH AAR G+  +++ 
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKL 521

Query: 584 LLQNGASTEIQNRLKETPLKCALNS----KILSVMEAYHLSFERRQKSSEAPVQSPQRSV 639
           LL+N A+  +      TPL  A        +L+++E         +++S+A +     + 
Sbjct: 522 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLE---------KEASQACMTKKGFTP 572

Query: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDA 699
             ++ +      + +               +  L  AV   +L++V+ LL         A
Sbjct: 573 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 632

Query: 700 EDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS----GLGVNVTSQDGSSPLHVAALHG 755
            +  +             P    A++   +V  S    G   N  S  G +PLH+AA  G
Sbjct: 633 WNGYT-------------PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG 679

Query: 756 RADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLI 815
            A+++ LLL   AN    N     PLHL  Q+GH  V   L+      +     G TPL 
Sbjct: 680 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 739

Query: 816 YACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKR 875
            A   G+ +LV  LLQH A +NA    G + LH+A  + H  +V LLL +GAS   ++  
Sbjct: 740 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 799

Query: 876 QRTAVDCAEQNS--KIMELLQVV-----------------PSCVASLDDVAETDRKEYVT 916
             T +  A++     + ++L+VV                 P  V  + DV+E +   ++T
Sbjct: 800 GTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHIT 859

Query: 917 V 917
           +
Sbjct: 860 I 860



 Score =  156 bits (395), Expect = 8e-38
 Identities = 136/466 (29%), Positives = 203/466 (43%), Gaps = 50/466 (10%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           +G+T LH+AA+ GQ  ++  LV+ GA VNA    G TPL++A Q+ +  V   LL   A+
Sbjct: 110 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 169

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVES-CRL---------------------- 558
             V   +G TPL +A   GHE+ V  L+ Y  +   RL                      
Sbjct: 170 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 229

Query: 559 ---DIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCAL---NSKILS 612
              D+ ++ G TPLHIAA +    V + LL  GAS     +   TPL  A    N  ++ 
Sbjct: 230 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 289

Query: 613 VMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEK 672
           ++       E + K    P+    R+      E      + + A ++   +         
Sbjct: 290 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP-------- 341

Query: 673 LLRAVADGD-LEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVP 731
            +   A GD L+ VR LL++   D E  + T+    P   H    C        R+AKV 
Sbjct: 342 -IHMAAQGDHLDCVRLLLQY---DAEIDDITLDHLTP--LHVAAHC-----GHHRVAKVL 390

Query: 732 AS-GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHF 790
              G   N  + +G +PLH+A       ++ LLLK GA+  A       PLH+A   GH 
Sbjct: 391 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 450

Query: 791 QVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEA 850
            +VK LL   A PN  ++   TPL  A   GH E+   LLQ+ A +NA      T LH A
Sbjct: 451 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 510

Query: 851 VIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVV 896
               H  +V+LLL + A+  +      T +  A +   +  +L ++
Sbjct: 511 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 556



 Score =  153 bits (387), Expect = 7e-37
 Identities = 120/423 (28%), Positives = 193/423 (45%), Gaps = 38/423 (8%)

Query: 486 GAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCV 545
           G  +N  + +G   LHLA ++G+  + + LLH +   E     GNT LH+A   G ++ V
Sbjct: 68  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 127

Query: 546 KALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCA 605
           + LV Y      ++  ++KG TPL++AA+  +  V++ LL+NGA+  +      TPL  A
Sbjct: 128 RELVNY---GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184

Query: 606 LNSKILSV--------------MEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTS-- 649
           L     +V              + A H++       + A +     + D +S+   T   
Sbjct: 185 LQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLH 244

Query: 650 --------SFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAED 701
                   + + +  +            +  L  A   G++ MVR LL+   +     +D
Sbjct: 245 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD 304

Query: 702 TVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS-GLGVNVTSQDGSSPLHVAALHGRADLI 760
            ++   P  C              R++++    G  +   +++G SP+H+AA     D +
Sbjct: 305 ELT---PLHC-------AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 354

Query: 761 PLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSG 820
            LLL++ A       D   PLH+A   GH +V K LLD  AKPN + L+G TPL  AC  
Sbjct: 355 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 414

Query: 821 GHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAV 880
            H  ++ LLL+ GASI+A    G T LH A    H+ +V+ LL  GAS  V N +  T +
Sbjct: 415 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 474

Query: 881 DCA 883
             A
Sbjct: 475 HMA 477



 Score =  114 bits (285), Expect = 5e-25
 Identities = 114/415 (27%), Positives = 172/415 (41%), Gaps = 26/415 (6%)

Query: 497 ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESC 556
           AT    A + G     L  L         + NG   LHLA   GH   V  L++ ++   
Sbjct: 46  ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII-- 103

Query: 557 RLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEA 616
            L+   +KG+T LHIAA  G   V+  L+  GA+   Q++   TPL  A     L V++ 
Sbjct: 104 -LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK- 161

Query: 617 YHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRA 676
           + L     Q  +     +P         E+  +   +     +          +  L  A
Sbjct: 162 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV--------RLPALHIA 213

Query: 677 VADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLG 736
             + D      LL+      +   D +S       H          AQ  L +    G  
Sbjct: 214 ARNDDTRTAAVLLQ-----NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR----GAS 264

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           VN T Q+G +PLH+A+  G   ++ LLL  GA    +  D+  PLH A + GH ++ + L
Sbjct: 265 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
           LD  A    K  +G +P+  A  G H + V LLLQ+ A I+       T LH A    H 
Sbjct: 325 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 384

Query: 857 FVVELLLLHGA--SVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAET 909
            V ++LL  GA  + + LN      + C + + ++MELL       AS+D V E+
Sbjct: 385 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL---KTGASIDAVTES 436



 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 64/201 (31%), Positives = 97/201 (48%), Gaps = 5/201 (2%)

Query: 404 HIAS--GNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDD 461
           H+A+  G  +  E LL ++ H     +    PL        L   +L  P   +P S   
Sbjct: 574 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 633

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
            G+TPLH+AA   Q  +   L+  G   NA    G TPLHLA Q+G+  +  LLL  +A+
Sbjct: 634 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 693

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
             + + +G TPLHL    GH      L+ + V    +D     G TPLH+A+ +G   ++
Sbjct: 694 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV---MVDATTRMGYTPLHVASHYGNIKLV 750

Query: 582 ETLLQNGASTEIQNRLKETPL 602
           + LLQ+ A    + +L  +PL
Sbjct: 751 KFLLQHQADVNAKTKLGYSPL 771



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 70/276 (25%), Positives = 118/276 (42%), Gaps = 38/276 (13%)

Query: 644 QESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTV 703
           QE      S+    +R  + KK        LRA   G+L+          + L +  D +
Sbjct: 20  QEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKAL-------DHLRNGVD-I 71

Query: 704 SAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLL 763
           +  +    + L    K     K + ++    + +  T++ G++ LH+AAL G+ +++  L
Sbjct: 72  NTCNQNGLNGLHLASKEGHV-KMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 130

Query: 764 LKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHH 823
           + +GAN  A++     PL++A Q+ H +VVK LL++ A  N     G TPL  A   GH 
Sbjct: 131 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 190

Query: 824 ELVALLLQHGAS---------INASNN--------------------KGNTALHEAVIEK 854
            +VA L+ +G           I A N+                     G T LH A   +
Sbjct: 191 NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 250

Query: 855 HVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIM 890
           ++ V +LLL  GASV    +   T +  A +   ++
Sbjct: 251 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 286



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 27/98 (27%), Positives = 43/98 (43%), Gaps = 3/98 (3%)

Query: 799 SNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFV 858
           + ++  KK     T  + A   G+ +     L++G  IN  N  G   LH A  E HV +
Sbjct: 34  NRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 93

Query: 859 VELLLLHGASVQVLNKRQRTAVDCAE---QNSKIMELL 893
           V  LL     ++   K+  TA+  A    Q+  + EL+
Sbjct: 94  VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 131


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  169 bits (427), Expect = 2e-41
 Identities = 133/431 (30%), Positives = 196/431 (45%), Gaps = 52/431 (12%)

Query: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
           TPLHVAA CG   +  +L+ KGA  N+   +G TPLH+AC+K +  V  LLL   AS + 
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
              +G TPLH+A   GH   VK L+         ++ N K +TPLH+AAR G+  V + L
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASP---NVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 585 LQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQ 644
           LQN A    + +  +TPL CA      ++++   L  E     + A              
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVK---LLLENNANPNLA-------------- 499

Query: 645 ESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVS 704
             +T+  + +  ++R+                   G +E V  LLE   ++   A  T  
Sbjct: 500 --TTAGHTPLHIAARE-------------------GHVETVLALLE---KEASQACMTKK 535

Query: 705 AADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLL 764
              P   H   +  K   A+  L +        N   ++G +PLHVA  H   D++ LLL
Sbjct: 536 GFTP--LHVAAKYGKVRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 765 KHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHE 824
             G +  +   +   PLH+A +Q   +V + LL      N + + G TPL  A   GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 825 LVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAE 884
           +VALLL   A+ N  N  G T LH    E HV V ++L+ HG  V    +   T +  A 
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709

Query: 885 Q--NSKIMELL 893
              N K+++ L
Sbjct: 710 HYGNIKLVKFL 720



 Score =  161 bits (408), Expect = 3e-39
 Identities = 144/546 (26%), Positives = 234/546 (42%), Gaps = 55/546 (10%)

Query: 406 ASGNQKEVERLLSQEDHDKDTVQKMCH--PLCFCDDCEKLVSGRLNDPSVVTPFSRDDRG 463
           A G+  +  RLL Q D + D +  + H  PL     C      ++       P SR   G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDIT-LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 464 HTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAE 523
            TPLH+A       +++LL+  GA ++A    G TPLH+A   G+  +   LL   AS  
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 524 VQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIET 583
           V +    TPLH+A   GH +  K L+       +++   +   TPLH AAR G+  +++ 
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 584 LLQNGASTEIQNRLKETPLKCALNS----KILSVMEAYHLSFERRQKSSEAPVQSPQRSV 639
           LL+N A+  +      TPL  A        +L+++E         +++S+A +     + 
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLE---------KEASQACMTKKGFTP 539

Query: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDA 699
             ++ +      + +               +  L  AV   +L++V+ LL         A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 700 EDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS----GLGVNVTSQDGSSPLHVAALHG 755
            +  +             P    A++   +V  S    G   N  S  G +PLH+AA  G
Sbjct: 600 WNGYT-------------PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG 646

Query: 756 RADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLI 815
            A+++ LLL   AN    N     PLHL  Q+GH  V   L+      +     G TPL 
Sbjct: 647 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706

Query: 816 YACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKR 875
            A   G+ +LV  LLQH A +NA    G + LH+A  + H  +V LLL +GAS   ++  
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 876 QRTAVDCAEQNS--KIMELLQVV-----------------PSCVASLDDVAETDRKEYVT 916
             T +  A++     + ++L+VV                 P  V  + DV+E + +E ++
Sbjct: 767 GTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELIS 826

Query: 917 VKIRKK 922
            K  ++
Sbjct: 827 FKAERR 832



 Score =  156 bits (395), Expect = 8e-38
 Identities = 136/466 (29%), Positives = 203/466 (43%), Gaps = 50/466 (10%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           +G+T LH+AA+ GQ  ++  LV+ GA VNA    G TPL++A Q+ +  V   LL   A+
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVES-CRL---------------------- 558
             V   +G TPL +A   GHE+ V  L+ Y  +   RL                      
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 559 ---DIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCAL---NSKILS 612
              D+ ++ G TPLHIAA +    V + LL  GAS     +   TPL  A    N  ++ 
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256

Query: 613 VMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEK 672
           ++       E + K    P+    R+      E      + + A ++   +         
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP-------- 308

Query: 673 LLRAVADGD-LEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVP 731
            +   A GD L+ VR LL++   D E  + T+    P   H    C        R+AKV 
Sbjct: 309 -IHMAAQGDHLDCVRLLLQY---DAEIDDITLDHLTP--LHVAAHC-----GHHRVAKVL 357

Query: 732 AS-GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHF 790
              G   N  + +G +PLH+A       ++ LLLK GA+  A       PLH+A   GH 
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417

Query: 791 QVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEA 850
            +VK LL   A PN  ++   TPL  A   GH E+   LLQ+ A +NA      T LH A
Sbjct: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477

Query: 851 VIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVV 896
               H  +V+LLL + A+  +      T +  A +   +  +L ++
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523



 Score =  153 bits (387), Expect = 7e-37
 Identities = 120/423 (28%), Positives = 193/423 (45%), Gaps = 38/423 (8%)

Query: 486 GAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCV 545
           G  +N  + +G   LHLA ++G+  + + LLH +   E     GNT LH+A   G ++ V
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 546 KALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCA 605
           + LV Y      ++  ++KG TPL++AA+  +  V++ LL+NGA+  +      TPL  A
Sbjct: 95  RELVNY---GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151

Query: 606 LNSKILSV--------------MEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTS-- 649
           L     +V              + A H++       + A +     + D +S+   T   
Sbjct: 152 LQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLH 211

Query: 650 --------SFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAED 701
                   + + +  +            +  L  A   G++ MVR LL+   +     +D
Sbjct: 212 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD 271

Query: 702 TVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS-GLGVNVTSQDGSSPLHVAALHGRADLI 760
            ++   P  C              R++++    G  +   +++G SP+H+AA     D +
Sbjct: 272 ELT---PLHC-------AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321

Query: 761 PLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSG 820
            LLL++ A       D   PLH+A   GH +V K LLD  AKPN + L+G TPL  AC  
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381

Query: 821 GHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAV 880
            H  ++ LLL+ GASI+A    G T LH A    H+ +V+ LL  GAS  V N +  T +
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441

Query: 881 DCA 883
             A
Sbjct: 442 HMA 444



 Score =  114 bits (285), Expect = 5e-25
 Identities = 114/415 (27%), Positives = 172/415 (41%), Gaps = 26/415 (6%)

Query: 497 ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESC 556
           AT    A + G     L  L         + NG   LHLA   GH   V  L++ ++   
Sbjct: 13  ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII-- 70

Query: 557 RLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEA 616
            L+   +KG+T LHIAA  G   V+  L+  GA+   Q++   TPL  A     L V++ 
Sbjct: 71  -LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK- 128

Query: 617 YHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRA 676
           + L     Q  +     +P         E+  +   +     +          +  L  A
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV--------RLPALHIA 180

Query: 677 VADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLG 736
             + D      LL+      +   D +S       H          AQ  L +    G  
Sbjct: 181 ARNDDTRTAAVLLQ-----NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR----GAS 231

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           VN T Q+G +PLH+A+  G   ++ LLL  GA    +  D+  PLH A + GH ++ + L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
           LD  A    K  +G +P+  A  G H + V LLLQ+ A I+       T LH A    H 
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351

Query: 857 FVVELLLLHGA--SVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAET 909
            V ++LL  GA  + + LN      + C + + ++MELL       AS+D V E+
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL---KTGASIDAVTES 403



 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 64/201 (31%), Positives = 97/201 (48%), Gaps = 5/201 (2%)

Query: 404 HIAS--GNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDD 461
           H+A+  G  +  E LL ++ H     +    PL        L   +L  P   +P S   
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
            G+TPLH+AA   Q  +   L+  G   NA    G TPLHLA Q+G+  +  LLL  +A+
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
             + + +G TPLHL    GH      L+ + V    +D     G TPLH+A+ +G   ++
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV---MVDATTRMGYTPLHVASHYGNIKLV 717

Query: 582 ETLLQNGASTEIQNRLKETPL 602
           + LLQ+ A    + +L  +PL
Sbjct: 718 KFLLQHQADVNAKTKLGYSPL 738



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 66/215 (30%), Positives = 107/215 (49%), Gaps = 6/215 (2%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           +G TPLH+AA  G A ++ LL+SK A  N  +  G TPLHL  Q+G+  V  +L+ +   
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
            +     G TPLH+A  YG+   VK L+ +  +   ++   + G +PLH AA+ G+  ++
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 582 ETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQ--KSSEAPVQSPQRSV 639
             LL+NGAS    +    TPL  A     +SV +   +  +       S+    S   +V
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETV 810

Query: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLL 674
           D I   S       +S  + + ++ +D  E ++LL
Sbjct: 811 DEILDVSEDEGEELISFKAERRDS-RDVDEEKELL 844



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 48/149 (32%), Positives = 71/149 (47%)

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           V     D ++    AA  G  D     L++G +    N +    LHLA ++GH ++V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
           L            GNT L  A   G  E+V  L+ +GA++NA + KG T L+ A  E H+
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 857 FVVELLLLHGASVQVLNKRQRTAVDCAEQ 885
            VV+ LL +GA+  V  +   T +  A Q
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQ 153



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 34/121 (28%), Positives = 54/121 (44%)

Query: 769 NAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVAL 828
           + G R AD A     A + G+       L +    N  + +G   L  A   GH ++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 829 LLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSK 888
           LL     +  +  KGNTALH A +     VV  L+ +GA+V   +++  T +  A Q + 
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 889 I 889
           +
Sbjct: 124 L 124


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  169 bits (427), Expect = 2e-41
 Identities = 133/431 (30%), Positives = 196/431 (45%), Gaps = 52/431 (12%)

Query: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
           TPLHVAA CG   +  +L+ KGA  N+   +G TPLH+AC+K +  V  LLL   AS + 
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
              +G TPLH+A   GH   VK L+         ++ N K +TPLH+AAR G+  V + L
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASP---NVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 585 LQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQ 644
           LQN A    + +  +TPL CA      ++++   L  E     + A              
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVK---LLLENNANPNLA-------------- 499

Query: 645 ESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVS 704
             +T+  + +  ++R+                   G +E V  LLE   ++   A  T  
Sbjct: 500 --TTAGHTPLHIAARE-------------------GHVETVLALLE---KEASQACMTKK 535

Query: 705 AADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLL 764
              P   H   +  K   A+  L +        N   ++G +PLHVA  H   D++ LLL
Sbjct: 536 GFTP--LHVAAKYGKVRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 765 KHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHE 824
             G +  +   +   PLH+A +Q   +V + LL      N + + G TPL  A   GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 825 LVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAE 884
           +VALLL   A+ N  N  G T LH    E HV V ++L+ HG  V    +   T +  A 
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709

Query: 885 Q--NSKIMELL 893
              N K+++ L
Sbjct: 710 HYGNIKLVKFL 720



 Score =  161 bits (408), Expect = 3e-39
 Identities = 144/546 (26%), Positives = 234/546 (42%), Gaps = 55/546 (10%)

Query: 406 ASGNQKEVERLLSQEDHDKDTVQKMCH--PLCFCDDCEKLVSGRLNDPSVVTPFSRDDRG 463
           A G+  +  RLL Q D + D +  + H  PL     C      ++       P SR   G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDIT-LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 464 HTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAE 523
            TPLH+A       +++LL+  GA ++A    G TPLH+A   G+  +   LL   AS  
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 524 VQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIET 583
           V +    TPLH+A   GH +  K L+       +++   +   TPLH AAR G+  +++ 
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 584 LLQNGASTEIQNRLKETPLKCALNS----KILSVMEAYHLSFERRQKSSEAPVQSPQRSV 639
           LL+N A+  +      TPL  A        +L+++E         +++S+A +     + 
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLE---------KEASQACMTKKGFTP 539

Query: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDA 699
             ++ +      + +               +  L  AV   +L++V+ LL         A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 700 EDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS----GLGVNVTSQDGSSPLHVAALHG 755
            +  +             P    A++   +V  S    G   N  S  G +PLH+AA  G
Sbjct: 600 WNGYT-------------PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG 646

Query: 756 RADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLI 815
            A+++ LLL   AN    N     PLHL  Q+GH  V   L+      +     G TPL 
Sbjct: 647 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706

Query: 816 YACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKR 875
            A   G+ +LV  LLQH A +NA    G + LH+A  + H  +V LLL +GAS   ++  
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 876 QRTAVDCAEQNS--KIMELLQVV-----------------PSCVASLDDVAETDRKEYVT 916
             T +  A++     + ++L+VV                 P  V  + DV+E + +E ++
Sbjct: 767 GTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELIS 826

Query: 917 VKIRKK 922
            K  ++
Sbjct: 827 FKAERR 832



 Score =  156 bits (395), Expect = 8e-38
 Identities = 136/466 (29%), Positives = 203/466 (43%), Gaps = 50/466 (10%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           +G+T LH+AA+ GQ  ++  LV+ GA VNA    G TPL++A Q+ +  V   LL   A+
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVES-CRL---------------------- 558
             V   +G TPL +A   GHE+ V  L+ Y  +   RL                      
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 559 ---DIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCAL---NSKILS 612
              D+ ++ G TPLHIAA +    V + LL  GAS     +   TPL  A    N  ++ 
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256

Query: 613 VMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEK 672
           ++       E + K    P+    R+      E      + + A ++   +         
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP-------- 308

Query: 673 LLRAVADGD-LEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVP 731
            +   A GD L+ VR LL++   D E  + T+    P   H    C        R+AKV 
Sbjct: 309 -IHMAAQGDHLDCVRLLLQY---DAEIDDITLDHLTP--LHVAAHC-----GHHRVAKVL 357

Query: 732 AS-GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHF 790
              G   N  + +G +PLH+A       ++ LLLK GA+  A       PLH+A   GH 
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417

Query: 791 QVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEA 850
            +VK LL   A PN  ++   TPL  A   GH E+   LLQ+ A +NA      T LH A
Sbjct: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477

Query: 851 VIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVV 896
               H  +V+LLL + A+  +      T +  A +   +  +L ++
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523



 Score =  153 bits (387), Expect = 7e-37
 Identities = 120/423 (28%), Positives = 193/423 (45%), Gaps = 38/423 (8%)

Query: 486 GAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCV 545
           G  +N  + +G   LHLA ++G+  + + LLH +   E     GNT LH+A   G ++ V
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 546 KALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCA 605
           + LV Y      ++  ++KG TPL++AA+  +  V++ LL+NGA+  +      TPL  A
Sbjct: 95  RELVNY---GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151

Query: 606 LNSKILSV--------------MEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTS-- 649
           L     +V              + A H++       + A +     + D +S+   T   
Sbjct: 152 LQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLH 211

Query: 650 --------SFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAED 701
                   + + +  +            +  L  A   G++ MVR LL+   +     +D
Sbjct: 212 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD 271

Query: 702 TVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS-GLGVNVTSQDGSSPLHVAALHGRADLI 760
            ++   P  C              R++++    G  +   +++G SP+H+AA     D +
Sbjct: 272 ELT---PLHC-------AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321

Query: 761 PLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSG 820
            LLL++ A       D   PLH+A   GH +V K LLD  AKPN + L+G TPL  AC  
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381

Query: 821 GHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAV 880
            H  ++ LLL+ GASI+A    G T LH A    H+ +V+ LL  GAS  V N +  T +
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441

Query: 881 DCA 883
             A
Sbjct: 442 HMA 444



 Score =  114 bits (285), Expect = 5e-25
 Identities = 114/415 (27%), Positives = 172/415 (41%), Gaps = 26/415 (6%)

Query: 497 ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESC 556
           AT    A + G     L  L         + NG   LHLA   GH   V  L++ ++   
Sbjct: 13  ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII-- 70

Query: 557 RLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEA 616
            L+   +KG+T LHIAA  G   V+  L+  GA+   Q++   TPL  A     L V++ 
Sbjct: 71  -LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK- 128

Query: 617 YHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRA 676
           + L     Q  +     +P         E+  +   +     +          +  L  A
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV--------RLPALHIA 180

Query: 677 VADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLG 736
             + D      LL+      +   D +S       H          AQ  L +    G  
Sbjct: 181 ARNDDTRTAAVLLQ-----NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR----GAS 231

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           VN T Q+G +PLH+A+  G   ++ LLL  GA    +  D+  PLH A + GH ++ + L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
           LD  A    K  +G +P+  A  G H + V LLLQ+ A I+       T LH A    H 
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351

Query: 857 FVVELLLLHGA--SVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAET 909
            V ++LL  GA  + + LN      + C + + ++MELL       AS+D V E+
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL---KTGASIDAVTES 403



 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 64/201 (31%), Positives = 97/201 (48%), Gaps = 5/201 (2%)

Query: 404 HIAS--GNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDD 461
           H+A+  G  +  E LL ++ H     +    PL        L   +L  P   +P S   
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
            G+TPLH+AA   Q  +   L+  G   NA    G TPLHLA Q+G+  +  LLL  +A+
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
             + + +G TPLHL    GH      L+ + V    +D     G TPLH+A+ +G   ++
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV---MVDATTRMGYTPLHVASHYGNIKLV 717

Query: 582 ETLLQNGASTEIQNRLKETPL 602
           + LLQ+ A    + +L  +PL
Sbjct: 718 KFLLQHQADVNAKTKLGYSPL 738



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 66/215 (30%), Positives = 107/215 (49%), Gaps = 6/215 (2%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           +G TPLH+AA  G A ++ LL+SK A  N  +  G TPLHL  Q+G+  V  +L+ +   
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
            +     G TPLH+A  YG+   VK L+ +  +   ++   + G +PLH AA+ G+  ++
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 582 ETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQ--KSSEAPVQSPQRSV 639
             LL+NGAS    +    TPL  A     +SV +   +  +       S+    S   +V
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETV 810

Query: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLL 674
           D I   S       +S  + + ++ +D  E ++LL
Sbjct: 811 DEILDVSEDEGEELISFKAERRDS-RDVDEEKELL 844



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 48/149 (32%), Positives = 71/149 (47%)

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           V     D ++    AA  G  D     L++G +    N +    LHLA ++GH ++V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
           L            GNT L  A   G  E+V  L+ +GA++NA + KG T L+ A  E H+
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 857 FVVELLLLHGASVQVLNKRQRTAVDCAEQ 885
            VV+ LL +GA+  V  +   T +  A Q
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQ 153



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 34/121 (28%), Positives = 54/121 (44%)

Query: 769 NAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVAL 828
           + G R AD A     A + G+       L +    N  + +G   L  A   GH ++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 829 LLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSK 888
           LL     +  +  KGNTALH A +     VV  L+ +GA+V   +++  T +  A Q + 
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 889 I 889
           +
Sbjct: 124 L 124


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  169 bits (427), Expect = 2e-41
 Identities = 133/431 (30%), Positives = 196/431 (45%), Gaps = 52/431 (12%)

Query: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
           TPLHVAA CG   +  +L+ KGA  N+   +G TPLH+AC+K +  V  LLL   AS + 
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
              +G TPLH+A   GH   VK L+         ++ N K +TPLH+AAR G+  V + L
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASP---NVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 585 LQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQ 644
           LQN A    + +  +TPL CA      ++++   L  E     + A              
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVK---LLLENNANPNLA-------------- 499

Query: 645 ESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVS 704
             +T+  + +  ++R+                   G +E V  LLE   ++   A  T  
Sbjct: 500 --TTAGHTPLHIAARE-------------------GHVETVLALLE---KEASQACMTKK 535

Query: 705 AADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLL 764
              P   H   +  K   A+  L +        N   ++G +PLHVA  H   D++ LLL
Sbjct: 536 GFTP--LHVAAKYGKVRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 765 KHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHE 824
             G +  +   +   PLH+A +Q   +V + LL      N + + G TPL  A   GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 825 LVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAE 884
           +VALLL   A+ N  N  G T LH    E HV V ++L+ HG  V    +   T +  A 
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709

Query: 885 Q--NSKIMELL 893
              N K+++ L
Sbjct: 710 HYGNIKLVKFL 720



 Score =  161 bits (408), Expect = 3e-39
 Identities = 144/546 (26%), Positives = 234/546 (42%), Gaps = 55/546 (10%)

Query: 406 ASGNQKEVERLLSQEDHDKDTVQKMCH--PLCFCDDCEKLVSGRLNDPSVVTPFSRDDRG 463
           A G+  +  RLL Q D + D +  + H  PL     C      ++       P SR   G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDIT-LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 464 HTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAE 523
            TPLH+A       +++LL+  GA ++A    G TPLH+A   G+  +   LL   AS  
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 524 VQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIET 583
           V +    TPLH+A   GH +  K L+       +++   +   TPLH AAR G+  +++ 
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 584 LLQNGASTEIQNRLKETPLKCALNS----KILSVMEAYHLSFERRQKSSEAPVQSPQRSV 639
           LL+N A+  +      TPL  A        +L+++E         +++S+A +     + 
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLE---------KEASQACMTKKGFTP 539

Query: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDA 699
             ++ +      + +               +  L  AV   +L++V+ LL         A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 700 EDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS----GLGVNVTSQDGSSPLHVAALHG 755
            +  +             P    A++   +V  S    G   N  S  G +PLH+AA  G
Sbjct: 600 WNGYT-------------PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG 646

Query: 756 RADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLI 815
            A+++ LLL   AN    N     PLHL  Q+GH  V   L+      +     G TPL 
Sbjct: 647 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706

Query: 816 YACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKR 875
            A   G+ +LV  LLQH A +NA    G + LH+A  + H  +V LLL +GAS   ++  
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 876 QRTAVDCAEQNS--KIMELLQVV-----------------PSCVASLDDVAETDRKEYVT 916
             T +  A++     + ++L+VV                 P  V  + DV+E + +E ++
Sbjct: 767 GTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELIS 826

Query: 917 VKIRKK 922
            K  ++
Sbjct: 827 FKAERR 832



 Score =  156 bits (395), Expect = 8e-38
 Identities = 136/466 (29%), Positives = 203/466 (43%), Gaps = 50/466 (10%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           +G+T LH+AA+ GQ  ++  LV+ GA VNA    G TPL++A Q+ +  V   LL   A+
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVES-CRL---------------------- 558
             V   +G TPL +A   GHE+ V  L+ Y  +   RL                      
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 559 ---DIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCAL---NSKILS 612
              D+ ++ G TPLHIAA +    V + LL  GAS     +   TPL  A    N  ++ 
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256

Query: 613 VMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEK 672
           ++       E + K    P+    R+      E      + + A ++   +         
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP-------- 308

Query: 673 LLRAVADGD-LEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVP 731
            +   A GD L+ VR LL++   D E  + T+    P   H    C        R+AKV 
Sbjct: 309 -IHMAAQGDHLDCVRLLLQY---DAEIDDITLDHLTP--LHVAAHC-----GHHRVAKVL 357

Query: 732 AS-GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHF 790
              G   N  + +G +PLH+A       ++ LLLK GA+  A       PLH+A   GH 
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417

Query: 791 QVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEA 850
            +VK LL   A PN  ++   TPL  A   GH E+   LLQ+ A +NA      T LH A
Sbjct: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477

Query: 851 VIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVV 896
               H  +V+LLL + A+  +      T +  A +   +  +L ++
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523



 Score =  153 bits (387), Expect = 7e-37
 Identities = 120/423 (28%), Positives = 193/423 (45%), Gaps = 38/423 (8%)

Query: 486 GAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCV 545
           G  +N  + +G   LHLA ++G+  + + LLH +   E     GNT LH+A   G ++ V
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 546 KALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCA 605
           + LV Y      ++  ++KG TPL++AA+  +  V++ LL+NGA+  +      TPL  A
Sbjct: 95  RELVNY---GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151

Query: 606 LNSKILSV--------------MEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTS-- 649
           L     +V              + A H++       + A +     + D +S+   T   
Sbjct: 152 LQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLH 211

Query: 650 --------SFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAED 701
                   + + +  +            +  L  A   G++ MVR LL+   +     +D
Sbjct: 212 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD 271

Query: 702 TVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS-GLGVNVTSQDGSSPLHVAALHGRADLI 760
            ++   P  C              R++++    G  +   +++G SP+H+AA     D +
Sbjct: 272 ELT---PLHC-------AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321

Query: 761 PLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSG 820
            LLL++ A       D   PLH+A   GH +V K LLD  AKPN + L+G TPL  AC  
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381

Query: 821 GHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAV 880
            H  ++ LLL+ GASI+A    G T LH A    H+ +V+ LL  GAS  V N +  T +
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441

Query: 881 DCA 883
             A
Sbjct: 442 HMA 444



 Score =  114 bits (285), Expect = 5e-25
 Identities = 114/415 (27%), Positives = 172/415 (41%), Gaps = 26/415 (6%)

Query: 497 ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESC 556
           AT    A + G     L  L         + NG   LHLA   GH   V  L++ ++   
Sbjct: 13  ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII-- 70

Query: 557 RLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEA 616
            L+   +KG+T LHIAA  G   V+  L+  GA+   Q++   TPL  A     L V++ 
Sbjct: 71  -LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK- 128

Query: 617 YHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRA 676
           + L     Q  +     +P         E+  +   +     +          +  L  A
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV--------RLPALHIA 180

Query: 677 VADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLG 736
             + D      LL+      +   D +S       H          AQ  L +    G  
Sbjct: 181 ARNDDTRTAAVLLQ-----NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR----GAS 231

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           VN T Q+G +PLH+A+  G   ++ LLL  GA    +  D+  PLH A + GH ++ + L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
           LD  A    K  +G +P+  A  G H + V LLLQ+ A I+       T LH A    H 
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351

Query: 857 FVVELLLLHGA--SVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAET 909
            V ++LL  GA  + + LN      + C + + ++MELL       AS+D V E+
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL---KTGASIDAVTES 403



 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 64/201 (31%), Positives = 97/201 (48%), Gaps = 5/201 (2%)

Query: 404 HIAS--GNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDD 461
           H+A+  G  +  E LL ++ H     +    PL        L   +L  P   +P S   
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
            G+TPLH+AA   Q  +   L+  G   NA    G TPLHLA Q+G+  +  LLL  +A+
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
             + + +G TPLHL    GH      L+ + V    +D     G TPLH+A+ +G   ++
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV---MVDATTRMGYTPLHVASHYGNIKLV 717

Query: 582 ETLLQNGASTEIQNRLKETPL 602
           + LLQ+ A    + +L  +PL
Sbjct: 718 KFLLQHQADVNAKTKLGYSPL 738



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 66/215 (30%), Positives = 107/215 (49%), Gaps = 6/215 (2%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           +G TPLH+AA  G A ++ LL+SK A  N  +  G TPLHL  Q+G+  V  +L+ +   
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
            +     G TPLH+A  YG+   VK L+ +  +   ++   + G +PLH AA+ G+  ++
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 582 ETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQ--KSSEAPVQSPQRSV 639
             LL+NGAS    +    TPL  A     +SV +   +  +       S+    S   +V
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETV 810

Query: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLL 674
           D I   S       +S  + + ++ +D  E ++LL
Sbjct: 811 DEILDVSEDEGEELISFKAERRDS-RDVDEEKELL 844



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 48/149 (32%), Positives = 71/149 (47%)

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           V     D ++    AA  G  D     L++G +    N +    LHLA ++GH ++V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
           L            GNT L  A   G  E+V  L+ +GA++NA + KG T L+ A  E H+
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 857 FVVELLLLHGASVQVLNKRQRTAVDCAEQ 885
            VV+ LL +GA+  V  +   T +  A Q
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQ 153



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 34/121 (28%), Positives = 54/121 (44%)

Query: 769 NAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVAL 828
           + G R AD A     A + G+       L +    N  + +G   L  A   GH ++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 829 LLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSK 888
           LL     +  +  KGNTALH A +     VV  L+ +GA+V   +++  T +  A Q + 
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 889 I 889
           +
Sbjct: 124 L 124


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  169 bits (427), Expect = 2e-41
 Identities = 133/431 (30%), Positives = 196/431 (45%), Gaps = 52/431 (12%)

Query: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
           TPLHVAA CG   +  +L+ KGA  N+   +G TPLH+AC+K +  V  LLL   AS + 
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
              +G TPLH+A   GH   VK L+         ++ N K +TPLH+AAR G+  V + L
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASP---NVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 585 LQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQ 644
           LQN A    + +  +TPL CA      ++++   L  E     + A              
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVK---LLLENNANPNLA-------------- 499

Query: 645 ESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVS 704
             +T+  + +  ++R+                   G +E V  LLE   ++   A  T  
Sbjct: 500 --TTAGHTPLHIAARE-------------------GHVETVLALLE---KEASQACMTKK 535

Query: 705 AADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLL 764
              P   H   +  K   A+  L +        N   ++G +PLHVA  H   D++ LLL
Sbjct: 536 GFTP--LHVAAKYGKVRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 765 KHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHE 824
             G +  +   +   PLH+A +Q   +V + LL      N + + G TPL  A   GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 825 LVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAE 884
           +VALLL   A+ N  N  G T LH    E HV V ++L+ HG  V    +   T +  A 
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709

Query: 885 Q--NSKIMELL 893
              N K+++ L
Sbjct: 710 HYGNIKLVKFL 720



 Score =  161 bits (408), Expect = 3e-39
 Identities = 144/546 (26%), Positives = 234/546 (42%), Gaps = 55/546 (10%)

Query: 406 ASGNQKEVERLLSQEDHDKDTVQKMCH--PLCFCDDCEKLVSGRLNDPSVVTPFSRDDRG 463
           A G+  +  RLL Q D + D +  + H  PL     C      ++       P SR   G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDIT-LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 464 HTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAE 523
            TPLH+A       +++LL+  GA ++A    G TPLH+A   G+  +   LL   AS  
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 524 VQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIET 583
           V +    TPLH+A   GH +  K L+       +++   +   TPLH AAR G+  +++ 
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 584 LLQNGASTEIQNRLKETPLKCALNS----KILSVMEAYHLSFERRQKSSEAPVQSPQRSV 639
           LL+N A+  +      TPL  A        +L+++E         +++S+A +     + 
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLE---------KEASQACMTKKGFTP 539

Query: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDA 699
             ++ +      + +               +  L  AV   +L++V+ LL         A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 700 EDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS----GLGVNVTSQDGSSPLHVAALHG 755
            +  +             P    A++   +V  S    G   N  S  G +PLH+AA  G
Sbjct: 600 WNGYT-------------PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG 646

Query: 756 RADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLI 815
            A+++ LLL   AN    N     PLHL  Q+GH  V   L+      +     G TPL 
Sbjct: 647 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706

Query: 816 YACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKR 875
            A   G+ +LV  LLQH A +NA    G + LH+A  + H  +V LLL +GAS   ++  
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 876 QRTAVDCAEQNS--KIMELLQVV-----------------PSCVASLDDVAETDRKEYVT 916
             T +  A++     + ++L+VV                 P  V  + DV+E + +E ++
Sbjct: 767 GTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELIS 826

Query: 917 VKIRKK 922
            K  ++
Sbjct: 827 FKAERR 832



 Score =  156 bits (395), Expect = 8e-38
 Identities = 136/466 (29%), Positives = 203/466 (43%), Gaps = 50/466 (10%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           +G+T LH+AA+ GQ  ++  LV+ GA VNA    G TPL++A Q+ +  V   LL   A+
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVES-CRL---------------------- 558
             V   +G TPL +A   GHE+ V  L+ Y  +   RL                      
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 559 ---DIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCAL---NSKILS 612
              D+ ++ G TPLHIAA +    V + LL  GAS     +   TPL  A    N  ++ 
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256

Query: 613 VMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEK 672
           ++       E + K    P+    R+      E      + + A ++   +         
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP-------- 308

Query: 673 LLRAVADGD-LEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVP 731
            +   A GD L+ VR LL++   D E  + T+    P   H    C        R+AKV 
Sbjct: 309 -IHMAAQGDHLDCVRLLLQY---DAEIDDITLDHLTP--LHVAAHC-----GHHRVAKVL 357

Query: 732 AS-GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHF 790
              G   N  + +G +PLH+A       ++ LLLK GA+  A       PLH+A   GH 
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417

Query: 791 QVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEA 850
            +VK LL   A PN  ++   TPL  A   GH E+   LLQ+ A +NA      T LH A
Sbjct: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477

Query: 851 VIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVV 896
               H  +V+LLL + A+  +      T +  A +   +  +L ++
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523



 Score =  153 bits (387), Expect = 7e-37
 Identities = 120/423 (28%), Positives = 193/423 (45%), Gaps = 38/423 (8%)

Query: 486 GAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCV 545
           G  +N  + +G   LHLA ++G+  + + LLH +   E     GNT LH+A   G ++ V
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 546 KALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCA 605
           + LV Y      ++  ++KG TPL++AA+  +  V++ LL+NGA+  +      TPL  A
Sbjct: 95  RELVNY---GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151

Query: 606 LNSKILSV--------------MEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTS-- 649
           L     +V              + A H++       + A +     + D +S+   T   
Sbjct: 152 LQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLH 211

Query: 650 --------SFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAED 701
                   + + +  +            +  L  A   G++ MVR LL+   +     +D
Sbjct: 212 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD 271

Query: 702 TVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS-GLGVNVTSQDGSSPLHVAALHGRADLI 760
            ++   P  C              R++++    G  +   +++G SP+H+AA     D +
Sbjct: 272 ELT---PLHC-------AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321

Query: 761 PLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSG 820
            LLL++ A       D   PLH+A   GH +V K LLD  AKPN + L+G TPL  AC  
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381

Query: 821 GHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAV 880
            H  ++ LLL+ GASI+A    G T LH A    H+ +V+ LL  GAS  V N +  T +
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441

Query: 881 DCA 883
             A
Sbjct: 442 HMA 444



 Score =  114 bits (285), Expect = 5e-25
 Identities = 114/415 (27%), Positives = 172/415 (41%), Gaps = 26/415 (6%)

Query: 497 ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESC 556
           AT    A + G     L  L         + NG   LHLA   GH   V  L++ ++   
Sbjct: 13  ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII-- 70

Query: 557 RLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEA 616
            L+   +KG+T LHIAA  G   V+  L+  GA+   Q++   TPL  A     L V++ 
Sbjct: 71  -LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK- 128

Query: 617 YHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRA 676
           + L     Q  +     +P         E+  +   +     +          +  L  A
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV--------RLPALHIA 180

Query: 677 VADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLG 736
             + D      LL+      +   D +S       H          AQ  L +    G  
Sbjct: 181 ARNDDTRTAAVLLQ-----NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR----GAS 231

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           VN T Q+G +PLH+A+  G   ++ LLL  GA    +  D+  PLH A + GH ++ + L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
           LD  A    K  +G +P+  A  G H + V LLLQ+ A I+       T LH A    H 
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351

Query: 857 FVVELLLLHGA--SVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAET 909
            V ++LL  GA  + + LN      + C + + ++MELL       AS+D V E+
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL---KTGASIDAVTES 403



 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 64/201 (31%), Positives = 97/201 (48%), Gaps = 5/201 (2%)

Query: 404 HIAS--GNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDD 461
           H+A+  G  +  E LL ++ H     +    PL        L   +L  P   +P S   
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
            G+TPLH+AA   Q  +   L+  G   NA    G TPLHLA Q+G+  +  LLL  +A+
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
             + + +G TPLHL    GH      L+ + V    +D     G TPLH+A+ +G   ++
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV---MVDATTRMGYTPLHVASHYGNIKLV 717

Query: 582 ETLLQNGASTEIQNRLKETPL 602
           + LLQ+ A    + +L  +PL
Sbjct: 718 KFLLQHQADVNAKTKLGYSPL 738



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 66/215 (30%), Positives = 107/215 (49%), Gaps = 6/215 (2%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           +G TPLH+AA  G A ++ LL+SK A  N  +  G TPLHL  Q+G+  V  +L+ +   
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
            +     G TPLH+A  YG+   VK L+ +  +   ++   + G +PLH AA+ G+  ++
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 582 ETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQ--KSSEAPVQSPQRSV 639
             LL+NGAS    +    TPL  A     +SV +   +  +       S+    S   +V
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETV 810

Query: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLL 674
           D I   S       +S  + + ++ +D  E ++LL
Sbjct: 811 DEILDVSEDEGEELISFKAERRDS-RDVDEEKELL 844



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 48/149 (32%), Positives = 71/149 (47%)

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           V     D ++    AA  G  D     L++G +    N +    LHLA ++GH ++V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
           L            GNT L  A   G  E+V  L+ +GA++NA + KG T L+ A  E H+
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 857 FVVELLLLHGASVQVLNKRQRTAVDCAEQ 885
            VV+ LL +GA+  V  +   T +  A Q
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQ 153



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 34/121 (28%), Positives = 54/121 (44%)

Query: 769 NAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVAL 828
           + G R AD A     A + G+       L +    N  + +G   L  A   GH ++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 829 LLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSK 888
           LL     +  +  KGNTALH A +     VV  L+ +GA+V   +++  T +  A Q + 
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 889 I 889
           +
Sbjct: 124 L 124


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  166 bits (419), Expect = 1e-40
 Identities = 129/472 (27%), Positives = 208/472 (44%), Gaps = 38/472 (8%)

Query: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
           T LHVAA CG   +  +L+ K A  NA   +G TPLH+AC+K    V  LLL + AS + 
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428

Query: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
              +G TP+H+A   GH + V  L+++       +  N +G+T LH+AAR G   V+  L
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASP---NTTNVRGETALHMAARSGQAEVVRYL 485

Query: 585 LQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQ 644
           +Q+GA  E + +  +TPL  +       +++       ++  S  A   S    +   ++
Sbjct: 486 VQDGAQVEAKAKDDQTPLHISARLGKADIVQ----QLLQQGASPNAATTSGYTPLHLSAR 541

Query: 645 ES--STSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDT 702
           E     ++F     +S    TKK +  +     A   G LE+   LL+ +       +  
Sbjct: 542 EGHEDVAAFLLDHGASLSITTKKGFTPLHV---AAKYGKLEVANLLLQKSASPDAAGKSG 598

Query: 703 VS--------------------AADPEFCHPLCQCPKCAPAQKRLAKVPAS----GLGVN 738
           ++                     A P         P    A+K    +  +    G   N
Sbjct: 599 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN 658

Query: 739 VTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLD 798
             ++ G + +H+AA  G  D++ LLL   AN    N     PLHLA Q+    V + L++
Sbjct: 659 AVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVN 718

Query: 799 SNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFV 858
             A  + +   G TPL   C  G+ ++V  LLQH A +NA    G T LH+A  + H  +
Sbjct: 719 QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 778

Query: 859 VELLLLHGASVQVLNKRQRTAVDCAEQNS--KIMELLQVVPSCVASLDDVAE 908
           + +LL + AS   L     TA+  A +     +++ L++V     +   V E
Sbjct: 779 INVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTE 830



 Score =  159 bits (402), Expect = 1e-38
 Identities = 131/456 (28%), Positives = 202/456 (44%), Gaps = 67/456 (14%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           +G+T LH+A++ GQA ++ +LV+ GA VNA   +G TPL++A Q+ +  V   LL   AS
Sbjct: 106 KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS 165

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTP-LHIAARWGYQGV 580
             +   +G TPL +A   GH+  V  L+  D +         K   P LHIAAR      
Sbjct: 166 QSLATEDGFTPLAVALQQGHDQVVSLLLENDTKG--------KVRLPALHIAARKDDTKA 217

Query: 581 IETLLQNGASTEIQNRLKETPLKCA-----LNSKILSVMEAYHLSFERRQKSSEAPVQSP 635
              LLQN  + +++++   TPL  A     +N   L +  A  + F  R   +   V S 
Sbjct: 218 AALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASK 277

Query: 636 QRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEED 695
           +                                           G+  MV+ LL      
Sbjct: 278 R-------------------------------------------GNANMVKLLL------ 288

Query: 696 LEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHG 755
             D    + A   +   PL  C   +  ++ +  +      +   +++G SPLH+A    
Sbjct: 289 --DRGAKIDAKTRDGLTPL-HCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGD 345

Query: 756 RADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLI 815
             + + LLL+H         D    LH+A   GH++V K LLD  A PN K L+G TPL 
Sbjct: 346 HLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLH 405

Query: 816 YACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKR 875
            AC     +++ LLL+HGASI A    G T +H A    HV +V  L+ HGAS    N R
Sbjct: 406 IACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR 465

Query: 876 QRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETDR 911
             TA+  A ++ +  E+++ +    A ++  A+ D+
Sbjct: 466 GETALHMAARSGQ-AEVVRYLVQDGAQVEAKAKDDQ 500



 Score =  158 bits (399), Expect = 3e-38
 Identities = 128/442 (28%), Positives = 200/442 (45%), Gaps = 19/442 (4%)

Query: 448 LNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKG 507
           LN  + V   +R+D   TPLHVA+  G A+++ LL+ +GA ++A    G TPLH   + G
Sbjct: 255 LNRAAAVDFTARNDI--TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSG 312

Query: 508 YQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDT 567
           ++ V  +LL   A    +  NG +PLH+A    H +CV+ L+ ++V     D+ N+   T
Sbjct: 313 HEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD--DVTNDYL-T 369

Query: 568 PLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKS 627
            LH+AA  G+  V + LL   A+   +     TPL  A     + VME       +   S
Sbjct: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMEL----LLKHGAS 425

Query: 628 SEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRY 687
            +A  +S    +   +     +  S +        T  + R    L  A   G  E+VRY
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTT-NVRGETALHMAARSGQAEVVRY 484

Query: 688 LLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSP 747
           L++   +    A+D     D    H   +  K    Q+ L +    G   N  +  G +P
Sbjct: 485 LVQDGAQVEAKAKD-----DQTPLHISARLGKADIVQQLLQQ----GASPNAATTSGYTP 535

Query: 748 LHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKD 807
           LH++A  G  D+   LL HGA+          PLH+A + G  +V   LL  +A P+   
Sbjct: 536 LHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAG 595

Query: 808 LSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGA 867
            SG TPL  A    + ++  LLL  GAS +A+   G T LH A  +  + +   LL +GA
Sbjct: 596 KSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGA 655

Query: 868 SVQVLNKRQRTAVDCAEQNSKI 889
               + ++   +V  A Q   +
Sbjct: 656 DANAVTRQGIASVHLAAQEGHV 677



 Score =  137 bits (344), Expect = 7e-32
 Identities = 120/466 (25%), Positives = 201/466 (43%), Gaps = 56/466 (12%)

Query: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLL-- 515
           ++   G TPL++AA      ++  L+  GA  +     G TPL +A Q+G+  V  LL  
Sbjct: 135 AQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE 194

Query: 516 -----------LHYKA----------------SAEVQDNNGNTPLHLACTYGHEDCVKAL 548
                      LH  A                +A+V+  +G TPLH+A  YG+ +    L
Sbjct: 195 NDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLL 254

Query: 549 VYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNS 608
           +     +  +D       TPLH+A++ G   +++ LL  GA  + + R   TPL C   S
Sbjct: 255 LN---RAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARS 311

Query: 609 KILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSS-----MSASSRQEET 663
               V+E   +  +R      AP+ S  ++  S    ++     +     +  +   ++ 
Sbjct: 312 GHEQVVE---MLLDR-----AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDV 363

Query: 664 KKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPA 723
             DY  +  L  A   G  ++ + LL   ++        ++   P   H  C+  +    
Sbjct: 364 TNDY--LTALHVAAHCGHYKVAKVLL---DKKANPNAKALNGFTP--LHIACKKNRI--- 413

Query: 724 QKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHL 783
            K +  +   G  +   ++ G +P+HVAA  G  +++  L+ HGA+    N      LH+
Sbjct: 414 -KVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHM 472

Query: 784 ACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKG 843
           A + G  +VV+ L+   A+   K     TPL  +   G  ++V  LLQ GAS NA+   G
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532

Query: 844 NTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKI 889
            T LH +  E H  V   LL HGAS+ +  K+  T +  A +  K+
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKL 578



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 64/210 (30%), Positives = 95/210 (45%), Gaps = 6/210 (2%)

Query: 426 TVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSK 485
           T +K   PL       KL    L      +P +    G TPLHVAA      +  LL+ +
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620

Query: 486 GAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCV 545
           GA  +A   +G TPLH+A +K    +   LL Y A A      G   +HLA   GH D V
Sbjct: 621 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 680

Query: 546 KALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCA 605
             L+     +  +++ N+ G TPLH+AA+     V E L+  GA  + Q ++  TPL   
Sbjct: 681 SLLL---GRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG 737

Query: 606 L---NSKILSVMEAYHLSFERRQKSSEAPV 632
               N KI++ +  +      + K+   P+
Sbjct: 738 CHYGNIKIVNFLLQHSAKVNAKTKNGYTPL 767



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 54/161 (33%), Positives = 84/161 (52%), Gaps = 3/161 (1%)

Query: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
           +G   +H+AA  G   ++ LL+ + A VN ++  G TPLHLA Q+   +V  +L++  A 
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH 722

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
            + Q   G TPLH+ C YG+   V  L+ +   S +++   + G TPLH AA+ G+  +I
Sbjct: 723 VDAQTKMGYTPLHVGCHYGNIKIVNFLLQH---SAKVNAKTKNGYTPLHQAAQQGHTHII 779

Query: 582 ETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFE 622
             LLQN AS         T L  A     +SV++   +  E
Sbjct: 780 NVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTE 820



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 54/177 (30%), Positives = 94/177 (53%), Gaps = 11/177 (6%)

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           V+  ++ G++ LH+A+L G+A+++ +L+ +GAN  A++ +   PL++A Q+ H +VVK L
Sbjct: 100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNT---ALHEAVIE 853
           LD+ A  +     G TPL  A   GH ++V+LLL+       ++ KG     ALH A  +
Sbjct: 160 LDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE-------NDTKGKVRLPALHIAARK 212

Query: 854 KHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETD 910
                  LLL +  +  V +K   T +  A     I  +  ++ +  A++D  A  D
Sbjct: 213 DDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNI-NVATLLLNRAAAVDFTARND 268



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 46/131 (35%), Positives = 71/131 (54%)

Query: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQV 792
           +G+ +N+ +Q+G + LH+A+  G  +++  LL+  AN  A        LH+A   G  +V
Sbjct: 63  NGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEV 122

Query: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVI 852
           VK L+ + A  N +  +G TPL  A    H E+V  LL +GAS + +   G T L  A+ 
Sbjct: 123 VKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQ 182

Query: 853 EKHVFVVELLL 863
           + H  VV LLL
Sbjct: 183 QGHDQVVSLLL 193



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 122/543 (22%), Positives = 199/543 (36%), Gaps = 75/543 (13%)

Query: 517  HYKASAE-VQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARW 575
            H K S +  + ++ N     A   GH +  KAL Y       ++I N+ G   LH+A++ 
Sbjct: 28   HRKRSRDRKKKSDANASYLRAARAGHLE--KALDYIK-NGVDINICNQNGLNALHLASKE 84

Query: 576  GYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSP 635
            G+  V+  LLQ  A+ +   +   T L               H++    Q      + + 
Sbjct: 85   GHVEVVSELLQREANVDAATKKGNTAL---------------HIASLAGQAEVVKVLVTN 129

Query: 636  QRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEED 695
              +V++ SQ   T                        L  A  +  LE+V++LL+     
Sbjct: 130  GANVNAQSQNGFTP-----------------------LYMAAQENHLEVVKFLLDNGASQ 166

Query: 696  LEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHG 755
                ED  +             P     Q+   +V +  L  +   +     LH+AA   
Sbjct: 167  SLATEDGFT-------------PLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKD 213

Query: 756  RADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLI 815
                  LLL++  NA   +     PLH+A   G+  V   LL+  A  +    +  TPL 
Sbjct: 214  DTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH 273

Query: 816  YACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKR 875
             A   G+  +V LLL  GA I+A    G T LH      H  VVE+LL   A +    K 
Sbjct: 274  VASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKN 333

Query: 876  QRTAVDCAEQNSKI--MELL--------QVVPSCVASLDDVAETDRKEYVTVKIRKKWNS 925
              + +  A Q   +  ++LL         V    + +L   A     +   V + KK N 
Sbjct: 334  GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN- 392

Query: 926  KLYDLPDEPFTRQFYFVHSA-GQFKGKTSREIMARDRSVPNLTEGSLHEPGRQSVTLRQN 984
                 P+      F  +H A  + + K    ++    S+  +TE  L  P   +  +   
Sbjct: 393  -----PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGL-TPIHVAAFMGHV 446

Query: 985  NLPAQSGSHAAEKGNSDWPERPGLTQTGPGHRRMLRRHTVEDAVVSQGPEAAGPLSTPQE 1044
            N+ +Q   H A    ++      L       +  + R+ V+D   +Q    A    TP  
Sbjct: 447  NIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDG--AQVEAKAKDDQTPLH 504

Query: 1045 VSA 1047
            +SA
Sbjct: 505  ISA 507



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 36/102 (35%), Positives = 49/102 (48%)

Query: 463 GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASA 522
           G+TPLHV    G   +++ L+   A VNA   +G TPLH A Q+G+  +  +LL   AS 
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 789

Query: 523 EVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEK 564
                NGNT L +A   G+   V  L     E+       EK
Sbjct: 790 NELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEK 831



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 20/54 (37%), Positives = 30/54 (55%)

Query: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSV 511
           ++   G+TPLH AA  G   +I++L+   A  N    +G T L +A + GY SV
Sbjct: 758 AKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISV 811


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  154 bits (390), Expect = 3e-37
 Identities = 132/446 (29%), Positives = 207/446 (46%), Gaps = 65/446 (14%)

Query: 460  DDRGHTPLHVAAVC-----GQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLL 514
            D  G T L VAA+C     G AS++ LL+ +GA V+  D  G TPL +A  +G+  V  L
Sbjct: 707  DVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDL 766

Query: 515  LLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAAR 574
            LL   A  +  DNNG TPL  A + GH   V  L+++      +D  + +G T L IA+ 
Sbjct: 767  LLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW---GAAVDSIDSEGRTVLSIASA 823

Query: 575  WGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQS 634
             G   V+ TLL  G     ++    TPL  A              +FE  +   EA ++ 
Sbjct: 824  QGNVEVVRTLLDRGLDENHRDDAGWTPLHMA--------------AFEGHRLICEALIEQ 869

Query: 635  PQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEE 694
                                   +R  E   D R     + A  +G  + V+ LLE  + 
Sbjct: 870  ----------------------GARTNEIDNDGRI--PFILASQEGHYDCVQILLE-NKS 904

Query: 695  DLE----DAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHV 750
            +++    D  + +  A  E    + +             + + G  VN    DG   L++
Sbjct: 905  NIDQRGYDGRNALRVAALEGHRDIVEL------------LFSHGADVNCKDADGRPTLYI 952

Query: 751  AALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSG 810
             AL  +  +    L++GAN  A +A+    LH++C QGH ++V+ L+  +A  N  D   
Sbjct: 953  LALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEK 1012

Query: 811  NTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQ 870
             + L  A   GH ++V LL++HGA ++ + N+G TAL  A  E H+ VV++LL HGA   
Sbjct: 1013 RSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPN 1072

Query: 871  VLNKRQRTAVDCAEQN--SKIMELLQ 894
              ++  RTA+  A +N  S+I++LL+
Sbjct: 1073 HADQFGRTAMRVAAKNGHSQIIKLLE 1098



 Score =  147 bits (370), Expect = 7e-35
 Identities = 121/416 (29%), Positives = 188/416 (45%), Gaps = 24/416 (5%)

Query: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
           D  G T L  AA  G   +++LLVS+GA +   D HG TPL LA ++G+  V   L+   
Sbjct: 542 DSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCG 601

Query: 520 ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQG 579
           A+    D +G T L  A   GH + V AL+Y  V   ++D  +    T L  AA  G++ 
Sbjct: 602 ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV---KVDCADADSRTALRAAAWGGHED 658

Query: 580 VIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSV 639
           ++  LLQ+GA     +    T L  A       ++E  HL     + + E        SV
Sbjct: 659 IVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVE--HLLDHGAEVNHEDVDGRTALSV 716

Query: 640 DSISQESST--SSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLE 697
            ++   +S   +S  S+      E    D   +  LL A  +G +++V  LLE       
Sbjct: 717 AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE------- 769

Query: 698 DAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS----GLGVNVTSQDGSSPLHVAAL 753
                   AD +      + P  A A    A V  +    G  V+    +G + L +A+ 
Sbjct: 770 ------GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASA 823

Query: 754 HGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTP 813
            G  +++  LL  G +   R+     PLH+A  +GH  + + L++  A+ N+ D  G  P
Sbjct: 824 QGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIP 883

Query: 814 LIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASV 869
            I A   GH++ V +LL++ ++I+     G  AL  A +E H  +VELL  HGA V
Sbjct: 884 FILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939



 Score =  134 bits (338), Expect = 3e-31
 Identities = 120/445 (26%), Positives = 189/445 (42%), Gaps = 62/445 (13%)

Query: 460  DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLAC-----QKGYQSVTLL 514
            D+ G T L  AA  G   +++ L+  GA VN  D  G T L +A       KG+ SV  L
Sbjct: 674  DNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSL 733

Query: 515  LLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAAR 574
            L+   A  +  D +G TPL +A   GH D V  L+    +   +D  +  G TPL  AA 
Sbjct: 734  LIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGAD---VDHTDNNGRTPLLAAAS 790

Query: 575  WGYQGVIETLLQNGASTEIQNRLKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAP 631
             G+  V+ TLL  GA+ +  +    T L  A    N +++  +    L    R  +   P
Sbjct: 791  MGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTP 850

Query: 632  VQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEW 691
            +         +  E+       +   +R  E   D R     + A  +G  + V+ LLE 
Sbjct: 851  LHMAAFEGHRLICEAL------IEQGARTNEIDNDGRI--PFILASQEGHYDCVQILLE- 901

Query: 692  TEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVA 751
                                                     +   ++    DG + L VA
Sbjct: 902  -----------------------------------------NKSNIDQRGYDGRNALRVA 920

Query: 752  ALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGN 811
            AL G  D++ LL  HGA+   ++AD    L++   +    + +  L++ A     D  G 
Sbjct: 921  ALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGR 980

Query: 812  TPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQV 871
            T L  +C  GH E+V +L+ + A +NA++N+  +AL  A  + HV VV+LL+ HGA V  
Sbjct: 981  TALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH 1040

Query: 872  LNKRQRTAVDCAEQNSKIMELLQVV 896
               +  TA+  A Q   I +++QV+
Sbjct: 1041 TCNQGATALCIAAQEGHI-DVVQVL 1064



 Score =  117 bits (293), Expect = 6e-26
 Identities = 123/434 (28%), Positives = 170/434 (39%), Gaps = 59/434 (13%)

Query: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLH 517
           S DDR  T   V     +   I  L+  GA VN  D +G T L  A   G   V  LL+ 
Sbjct: 509 SEDDR--TSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVS 566

Query: 518 YKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGN--EKGDTPLHIAARW 575
             A  E++D +G+TPL LA   GH   V  L+      C  +I +  + G T L  AA  
Sbjct: 567 RGADLEIEDAHGHTPLTLAARQGHTKVVNCLI-----GCGANINHTDQDGWTALRSAAWG 621

Query: 576 GYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSP 635
           G+  V+  LL  G   +  +    T L+ A                              
Sbjct: 622 GHTEVVSALLYAGVKVDCADADSRTALRAAAWG-------------------------GH 656

Query: 636 QRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEED 695
           +  V ++ Q  +             E  K D      L+ A   G  E+V +LL+   E 
Sbjct: 657 EDIVLNLLQHGA-------------EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAE- 702

Query: 696 LEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPA----SGLGVNVTSQDGSSPLHVA 751
                  V+  D +    L     C PA K  A V +     G  V+   +DG +PL VA
Sbjct: 703 -------VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVA 755

Query: 752 ALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGN 811
           A  G  D++ LLL+ GA+    + +   PL  A   GH  VV  LL   A  +  D  G 
Sbjct: 756 AYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR 815

Query: 812 TPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQV 871
           T L  A + G+ E+V  LL  G   N  ++ G T LH A  E H  + E L+  GA    
Sbjct: 816 TVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNE 875

Query: 872 LNKRQRTAVDCAEQ 885
           ++   R     A Q
Sbjct: 876 IDNDGRIPFILASQ 889



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 88/356 (24%), Positives = 148/356 (41%), Gaps = 54/356 (15%)

Query: 458  SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLH 517
            S D  G T L +A+  G   ++  L+ +G   N  D  G TPLH+A  +G++ +   L+ 
Sbjct: 809  SIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIE 868

Query: 518  YKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGY 577
              A     DN+G  P  LA   GH DCV+ L+        +D     G   L +AA  G+
Sbjct: 869  QGARTNEIDNDGRIPFILASQEGHYDCVQILL---ENKSNIDQRGYDGRNALRVAALEGH 925

Query: 578  QGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQR 637
            + ++E L  +GA    ++      L              Y L+ E +   +E  +++   
Sbjct: 926  RDIVELLFSHGADVNCKDADGRPTL--------------YILALENQLTMAEYFLENG-- 969

Query: 638  SVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLE 697
                          +++ AS  +  T         L  +   G +EMV+ L+ +  +   
Sbjct: 970  --------------ANVEASDAEGRT--------ALHVSCWQGHMEMVQVLIAYHAD--- 1004

Query: 698  DAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRA 757
                 V+AAD E    L Q        K +  +   G  V+ T   G++ L +AA  G  
Sbjct: 1005 -----VNAADNEKRSAL-QSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHI 1058

Query: 758  DLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTP 813
            D++ +LL+HGA+    +      + +A + GH Q++K L     K     L+G +P
Sbjct: 1059 DVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL----EKYGASSLNGCSP 1110



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 80/332 (24%), Positives = 133/332 (40%), Gaps = 68/332 (20%)

Query: 459  RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
            RDD G TPLH+AA  G   + + L+ +GA  N  D  G  P  LA Q+G+     +LL  
Sbjct: 843  RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 902

Query: 519  KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQ 578
            K++ + +  +G   L +A   GH D V+ L  +  +   ++  +  G   L+I A     
Sbjct: 903  KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGAD---VNCKDADGRPTLYILALENQL 959

Query: 579  GVIETLLQNGASTEIQNRLKETPLKCAL---NSKILSVMEAYHLSF-----ERRQKSSEA 630
             + E  L+NGA+ E  +    T L  +    + +++ V+ AYH        E+R     A
Sbjct: 960  TMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSA 1019

Query: 631  PVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLE 690
              Q   + V  + +  +    +    ++              L  A  +G +++V+ LLE
Sbjct: 1020 AWQGHVKVVQLLIEHGAVVDHTCNQGAT-------------ALCIAAQEGHIDVVQVLLE 1066

Query: 691  WTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHV 750
                           ADP                             N   Q G + + V
Sbjct: 1067 -------------HGADP-----------------------------NHADQFGRTAMRV 1084

Query: 751  AALHGRADLIPLLLKHGANAGARNADQAVPLH 782
            AA +G + +I LL K+GA+  + N     P+H
Sbjct: 1085 AAKNGHSQIIKLLEKYGAS--SLNGCSPSPVH 1114



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 56/204 (27%), Positives = 102/204 (50%), Gaps = 9/204 (4%)

Query: 459  RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
            +D  G   L++ A+  Q ++ +  +  GA V A+D  G T LH++C +G+  +  +L+ Y
Sbjct: 942  KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001

Query: 519  KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQ 578
             A     DN   + L  A   GH   V+ L+ +      +D    +G T L IAA+ G+ 
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEH---GAVVDHTCNQGATALCIAAQEGHI 1058

Query: 579  GVIETLLQNGASTEIQNRLKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAPVQS- 634
             V++ LL++GA     ++   T ++ A    +S+I+ ++E Y  S       S +PV + 
Sbjct: 1059 DVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS--SLNGCSPSPVHTM 1116

Query: 635  PQRSVDSISQESSTSSFSSMSASS 658
             Q+ + S+S +  + +  S S+ S
Sbjct: 1117 EQKPLQSLSSKVQSLTIKSNSSGS 1140


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  145 bits (367), Expect = 1e-34
 Identities = 132/519 (25%), Positives = 224/519 (43%), Gaps = 43/519 (8%)

Query: 437 CDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASL-IDLLVSKGAMVNATDYH 495
           C + + +V   L D   +    ++++G TPLH AA     +L ++LLV  GA VN     
Sbjct: 247 CYNGQDVVVNELIDCGAIVN-QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305

Query: 496 GATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVES 555
           G TPLH+    G  S +  ++   A  + +D NGNTPLH+A  YGHE  +  L+    ++
Sbjct: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADT 365

Query: 556 CRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCAL---NSKILS 612
            +  I    G  PLH+AA  G+      LL +G   +  +    T L  A    N + L+
Sbjct: 366 AKRGI---HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLN 422

Query: 613 VMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDY----- 667
           ++      F ++ K   +P+     + +     +   S +S++    +  T   Y     
Sbjct: 423 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 482

Query: 668 ---REVEKLLR------------------AVADGDLEMVRYLLEWTEEDL---EDAEDTV 703
              + +E LLR                  + A G    ++ +   T  D+       D +
Sbjct: 483 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 542

Query: 704 SAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLL 763
           S +D                 + L  +  S L ++V +  G +PL +AA  G  + + +L
Sbjct: 543 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602

Query: 764 LKHGANAGARN-ADQAVPLHLACQQGHFQVVKCLLDSNAKPNK----KDLSGNTPLIYAC 818
           +  GA+   ++   +  P+H A   GH + ++ LL  NA+P      +D +G TPL+ + 
Sbjct: 603 INQGASILVKDYILKRTPIHAAATNGHSECLR-LLIGNAEPQNAVDIQDGNGQTPLMLSV 661

Query: 819 SGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRT 878
             GH + V  LL  GA+++A +  G TALH   +  H   V+ LL HGA   + + R RT
Sbjct: 662 LNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRT 721

Query: 879 AVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKEYVTV 917
            +  +     I  L  ++ S  +   + A  D   Y  +
Sbjct: 722 PIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTAL 760



 Score =  132 bits (332), Expect = 2e-30
 Identities = 124/449 (27%), Positives = 192/449 (42%), Gaps = 59/449 (13%)

Query: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYH-GATPLHLACQKGYQSVTLLLL- 516
           R+  G TPL +AA  G    +D+L+++GA +   DY    TP+H A   G+     LL+ 
Sbjct: 579 RNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIG 638

Query: 517 --HYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAAR 574
               + + ++QD NG TPL L+   GH DCV +L+    +   +D  ++ G T LH  A 
Sbjct: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLN---KGANVDAKDKWGRTALHRGAV 695

Query: 575 WGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQS 634
            G++  ++ LLQ+GA   +++    TP+  +     + V+ A                  
Sbjct: 696 TGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL----------------- 738

Query: 635 PQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEE 694
                          S +SM A+        D      L  A  +G    V  LLE  +E
Sbjct: 739 -------------LQSAASMDANP----ATADNHGYTALHWACYNGHETCVELLLE--QE 779

Query: 695 DLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLG---VNVTSQDGSSPLHVA 751
             +  E   +A  P  C  +          +  A++    LG   VN T   G +PLH A
Sbjct: 780 VFQKTEG--NAFSPLHCAVIND-------NEGAAEMLIDTLGASIVNATDSKGRTPLHAA 830

Query: 752 ALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDS-NAKPNKKDLSG 810
           A     + + LLL H A   + ++    PL +A + G    V+ L+ S +A+   +D S 
Sbjct: 831 AFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK 890

Query: 811 NTPLIYACSGGHHELVALLLQHGAS---INASNNKGNTALHEAVIEKHVFVVELLLLHGA 867
           NT L  ACS GH     L+L+       INA+N    T LH A       VV+ LL  GA
Sbjct: 891 NTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGA 950

Query: 868 SVQVLNKRQRTAVDCAEQNSKIMELLQVV 896
           SV  +++   T       N  + + L ++
Sbjct: 951 SVLAVDENGYTPALACAPNKDVADCLALI 979



 Score =  125 bits (314), Expect = 2e-28
 Identities = 142/530 (26%), Positives = 214/530 (40%), Gaps = 92/530 (17%)

Query: 436 FCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYH 495
           F D C KL+S   +   + TP   DD G T LH AA  G    ++LL++ GA  N  D  
Sbjct: 384 FSDCCRKLLSSGFD---IDTP---DDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 437

Query: 496 GATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVES 555
           G +PLH A           L+   AS    D  G TPLH A T   +   K L Y     
Sbjct: 438 GRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDG--KCLEYLLRND 495

Query: 556 CRLDIGNEKGDTPLHIAARWGYQGVIETL--------LQNGASTEI----QNRLKETPLK 603
               I +++G   +H +A +G++  ++ +        L   + T++     NR   +PL 
Sbjct: 496 ANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLH 555

Query: 604 CAL---NSKILSVMEAYHLSFERRQKSSEAPV-----QSPQRSVDSISQESSTSSFSSMS 655
            A    + + L V+    L  + R  S   P+     +     VD +  + ++       
Sbjct: 556 LAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV---- 611

Query: 656 ASSRQEETKKDYREVEKLLRAVA-DGDLEMVRYLLEWTE-EDLEDAEDTVSAADPEFCHP 713
                    KDY      + A A +G  E +R L+   E ++  D +D  +   P     
Sbjct: 612 ---------KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDG-NGQTPLMLSV 661

Query: 714 LCQCPKCAPAQKRLAKVPASGLGVNVTSQD--GSSPLHVAALHGRADLIPLLLKHGANAG 771
           L     C  +            G NV ++D  G + LH  A+ G  + +  LL+HGA   
Sbjct: 662 LNGHTDCVYS--------LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCL 713

Query: 772 ARNADQAVPLHLACQQGHFQVVKCLLDS----NAKPNKKDLSGNTPLIYACSGGHHELVA 827
            R++    P+HL+   GH  V+  LL S    +A P   D  G T L +AC  GH   V 
Sbjct: 714 LRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVE 773

Query: 828 LLLQH---------------------------------GASI-NASNNKGNTALHEAVIE 853
           LLL+                                  GASI NA+++KG T LH A   
Sbjct: 774 LLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFT 833

Query: 854 KHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASL 903
            HV  ++LLL H A V  ++   +T +  A +N +   +  +V S  A L
Sbjct: 834 DHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAEL 883



 Score =  124 bits (312), Expect = 4e-28
 Identities = 114/427 (26%), Positives = 173/427 (40%), Gaps = 53/427 (12%)

Query: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
           +D+   TPLH AA  G A +I+LL+  GA VNA D    TPLH A     +    +LL +
Sbjct: 37  QDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKH 96

Query: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQ 578
            A    +D N  TPLH+A       C +ALV        +++ +  G T LH AA  G+ 
Sbjct: 97  SADVNARDKNWQTPLHIAAANKAVKCAEALVPL---LSNVNVSDRAGRTALHHAAFSGHG 153

Query: 579 GVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRS 638
            +++ LL  GA+    ++     +  A     + V++                       
Sbjct: 154 EMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK----------------------- 190

Query: 639 VDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLED 698
                          +  S   E T KD +    L  A + G + +V+YLL     DL  
Sbjct: 191 ---------------LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL-----DLGV 230

Query: 699 AEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAAL--HGR 756
             +  +A      H  C   +     + +      G  VN  ++ G +PLH AA   HG 
Sbjct: 231 DMNEPNAYGNTPLHVACYNGQDVVVNELID----CGAIVNQKNEKGFTPLHFAAASTHG- 285

Query: 757 ADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIY 816
           A  + LL+ +GA+   ++ D   PLH+    G F   + ++ S A  + +D +GNTPL  
Sbjct: 286 ALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345

Query: 817 ACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876
           A   GH  L+  L+  GA        G   LH A +         LL  G  +   +   
Sbjct: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405

Query: 877 RTAVDCA 883
           RT +  A
Sbjct: 406 RTCLHAA 412



 Score =  122 bits (305), Expect = 2e-27
 Identities = 131/503 (26%), Positives = 210/503 (41%), Gaps = 33/503 (6%)

Query: 401 LFKHIASGNQKEVERLLSQ------EDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVV 454
           L + I +G+  EV  L+ +      +D++K T     H   +  D E +    L+   V 
Sbjct: 12  LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTP---LHAAAYLGDAEIIELLILSGARVN 68

Query: 455 TPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLL 514
              ++D +  TPLH A        + +L+   A VNA D +  TPLH+A           
Sbjct: 69  ---AKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEA 125

Query: 515 LLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAAR 574
           L+   ++  V D  G T LH A   GH + VK L+        ++  ++K    +H AA 
Sbjct: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLL---SRGANINAFDKKDRRAIHWAAY 182

Query: 575 WGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQS 634
            G+  V++ L+ +GA    +++   TPL  A +S ++SV++ Y L          A   +
Sbjct: 183 MGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVK-YLLDLGVDMNEPNAYGNT 241

Query: 635 PQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEE 694
           P        Q+   +      A   Q    K+ +    L  A A     +   LL     
Sbjct: 242 PLHVACYNGQDVVVNELIDCGAIVNQ----KNEKGFTPLHFAAASTHGALCLELLVGNGA 297

Query: 695 DLE-DAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAAL 753
           D+   ++D  +       H             R   +  SG  ++   ++G++PLH+AA 
Sbjct: 298 DVNMKSKDGKTPLHMTALH---------GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAAR 348

Query: 754 HGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTP 813
           +G   LI  L+  GA+   R      PLHLA   G     + LL S    +  D  G T 
Sbjct: 349 YGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTC 408

Query: 814 LIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLN 873
           L  A +GG+ E + LLL  GA  N  +  G + LH A    +   +  L+  GASV  L+
Sbjct: 409 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD 468

Query: 874 KRQRTAVDCA---EQNSKIMELL 893
           +R  T +  A   + + K +E L
Sbjct: 469 ERGCTPLHYAATSDTDGKCLEYL 491



 Score =  118 bits (295), Expect = 3e-26
 Identities = 147/555 (26%), Positives = 222/555 (40%), Gaps = 95/555 (17%)

Query: 404 HIASGNQ-----KEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFS 458
           HIA+ N+     + +  LLS  +      +   H   F    E +V   L+  + +  F 
Sbjct: 112 HIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGE-MVKLLLSRGANINAFD 170

Query: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
           + DR    +H AA  G   ++ LLVS GA V   D    TPLH A   G  SV   LL  
Sbjct: 171 KKDR--RAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL 228

Query: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIG--NEKGDTPLHIAARWG 576
                  +  GNTPLH+AC  G +  V  L+      C   +   NEKG TPLH AA   
Sbjct: 229 GVDMNEPNAYGNTPLHVACYNGQDVVVNELI-----DCGAIVNQKNEKGFTPLHFAAAST 283

Query: 577 YQGV-IETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQ---------- 625
           +  + +E L+ NGA   ++++  +TPL           M A H  F R Q          
Sbjct: 284 HGALCLELLVGNGADVNMKSKDGKTPLH----------MTALHGRFSRSQTIIQSGAVID 333

Query: 626 ---KSSEAPVQSPQR-------------SVDSISQE---------SSTSSFS----SMSA 656
              K+   P+    R               D+  +          ++ S FS     + +
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393

Query: 657 SSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLC- 715
           S    +T  D+     L  A A G+LE +  LL  T  D  + +D    +   +    C 
Sbjct: 394 SGFDIDTPDDFGRT-CLHAAAAGGNLECLNLLLN-TGADF-NKKDKFGRSPLHYAAANCN 450

Query: 716 -QCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGR-ADLIPLLLKHGANAGAR 773
            QC         L  +  SG  VN   + G +PLH AA        +  LL++ AN G R
Sbjct: 451 YQC---------LFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIR 501

Query: 774 NADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGN------------TPLIYACSGG 821
           +      +H +   GH   ++ +          + SG             +PL  A   G
Sbjct: 502 DKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHG 561

Query: 822 HHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNK-RQRTAV 880
           HH+ + +L+Q    ++  N+ G T L  A  + HV  V++L+  GAS+ V +   +RT +
Sbjct: 562 HHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPI 621

Query: 881 DCAEQN--SKIMELL 893
             A  N  S+ + LL
Sbjct: 622 HAAATNGHSECLRLL 636



 Score =  102 bits (254), Expect = 2e-21
 Identities = 96/363 (26%), Positives = 145/363 (39%), Gaps = 57/363 (15%)

Query: 540 GHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKE 599
           G  D V+AL++   +    D  NEK  TPLH AA  G   +IE L+ +GA    ++    
Sbjct: 19  GDPDEVRALIFKKEDVNFQD--NEKR-TPLHAAAYLGDAEIIELLILSGARVNAKDSKWL 75

Query: 600 TPLKCALNS---KILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSA 656
           TPL  A+ S   + + V+  +      R K+ + P+     +      E+     S+++ 
Sbjct: 76  TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV 135

Query: 657 SSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQ 716
           S R   T         L  A   G  EMV+ LL                           
Sbjct: 136 SDRAGRTA--------LHHAAFSGHGEMVKLLL--------------------------- 160

Query: 717 CPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNAD 776
                          + G  +N   +     +H AA  G  +++ LL+ HGA    ++  
Sbjct: 161 ---------------SRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK 205

Query: 777 QAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASI 836
              PLH A   G   VVK LLD     N+ +  GNTPL  AC  G   +V  L+  GA +
Sbjct: 206 SYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIV 265

Query: 837 NASNNKGNTALHEAVIEKH-VFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQV 895
           N  N KG T LH A    H    +ELL+ +GA V + +K  +T +     + +      +
Sbjct: 266 NQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTI 325

Query: 896 VPS 898
           + S
Sbjct: 326 IQS 328



 Score =  100 bits (249), Expect = 7e-21
 Identities = 83/254 (32%), Positives = 122/254 (48%), Gaps = 10/254 (3%)

Query: 407  SGNQKEVERLLSQEDHDKDTVQKMCHPL--CFCDDCEKLVSGRLNDPSVVTPFSRDDRGH 464
            +G++  VE LL QE   K T      PL     +D E      ++        + D +G 
Sbjct: 766  NGHETCVELLLEQEVFQK-TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGR 824

Query: 465  TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
            TPLH AA       + LL+S  A VN+ D  G TPL +A + G Q+ T+ +L   ASAE+
Sbjct: 825  TPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENG-QTNTVEMLVSSASAEL 883

Query: 525  --QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIE 582
              QDN+ NT LHLAC+ GHE     ++    +   ++  N    TPLH+AAR G   V++
Sbjct: 884  TLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQ 943

Query: 583  TLLQNGASTEIQNRLKETP-LKCALNSKILSVMEAYHLSFERRQKSSEAPVQS-PQRSVD 640
             LL  GAS    +    TP L CA N  +   +    +       SS +P+ S    +++
Sbjct: 944  ELLGKGASVLAVDENGYTPALACAPNKDVADCLAL--ILATMMPVSSSSPLSSLTFNAIN 1001

Query: 641  SISQESSTSSFSSM 654
              +  S T SF ++
Sbjct: 1002 RYTNTSKTVSFEAL 1015



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 71/222 (31%), Positives = 109/222 (49%), Gaps = 9/222 (4%)

Query: 668 REVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRL 727
           R+   L++A+ +GD + VR L+ + +ED       V+  D E   PL        A+  +
Sbjct: 7   RDQPSLVQAIFNGDPDEVRALI-FKKED-------VNFQDNEKRTPLHAAAYLGDAEI-I 57

Query: 728 AKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQ 787
             +  SG  VN       +PLH A      + + +LLKH A+  AR+ +   PLH+A   
Sbjct: 58  ELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAAN 117

Query: 788 GHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTAL 847
              +  + L+   +  N  D +G T L +A   GH E+V LLL  GA+INA + K   A+
Sbjct: 118 KAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAI 177

Query: 848 HEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKI 889
           H A    H+ VV+LL+ HGA V   +K+  T +  A  +  I
Sbjct: 178 HWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMI 219



 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 102/388 (26%), Positives = 162/388 (41%), Gaps = 28/388 (7%)

Query: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDY---HGATPLHLACQKGYQSVTLLLLHYKAS 521
           TP+H AA  G +  + LL+      NA D    +G TPL L+   G+      LL+  A+
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGAN 678

Query: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
            + +D  G T LH     GHE+CV AL+ +  +    D    +G TP+H++A  G+ GV+
Sbjct: 679 VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD---SRGRTPIHLSAACGHIGVL 735

Query: 582 ETLLQNGASTEIQNRLKETPLKCALNSKILSVMEA-YHLSFERRQ-KSSEAPVQSPQRSV 639
             LLQ+ AS +      +     AL+    +  E    L  E+   + +E    SP    
Sbjct: 736 GALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCA 795

Query: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDA 699
                E +         +S    T  D +    L  A     +E ++ LL    +     
Sbjct: 796 VINDNEGAAEMLIDTLGASIVNAT--DSKGRTPLHAAAFTDHVECLQLLLSHNAQ----- 848

Query: 700 EDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGS--SPLHVAALHGRA 757
              V++ D     PL    +    Q    ++  S     +T QD S  + LH+A   G  
Sbjct: 849 ---VNSVDSTGKTPLMMAAE--NGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHE 903

Query: 758 DLIPLLLKHGANAGARNADQAV---PLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPL 814
               L+L+   +    NA  A    PLH+A + G   VV+ LL   A     D +G TP 
Sbjct: 904 TSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPA 963

Query: 815 IYACSGGHH--ELVALLLQHGASINASN 840
           + AC+      + +AL+L     +++S+
Sbjct: 964 L-ACAPNKDVADCLALILATMMPVSSSS 990


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  132 bits (333), Expect = 1e-30
 Identities = 122/477 (25%), Positives = 183/477 (38%), Gaps = 68/477 (14%)

Query: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
           D    TPLHVAA  G A +I+LL+  GA VNA D    TPLH A     +    +L+ + 
Sbjct: 13  DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72

Query: 520 ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQG 579
           A    +D N  TPLH+A       C + ++        +++ +  G T LH AA  G+  
Sbjct: 73  ADVNARDKNWQTPLHVAAANKAVKCAEVIIPL---LSSVNVSDRGGRTALHHAALNGHVE 129

Query: 580 VIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSV 639
           ++  LL  GA+    ++     L  A     L V+                         
Sbjct: 130 MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVV------------------------- 164

Query: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEE----- 694
                        ++  +   E T KD +    L  A ++G + +V++LL    E     
Sbjct: 165 -------------ALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEIN 211

Query: 695 --------------------DLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASG 734
                               +L D    V+  +     PL            L  +  +G
Sbjct: 212 VYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNG 271

Query: 735 LGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVK 794
             VN+ S+DG SPLH+ A+HGR      L+++G      + D   PLH+A + GH  ++ 
Sbjct: 272 ADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLIN 331

Query: 795 CLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEK 854
            L  S A   K  +    PL  A    H +    LL  G  I+  +  G T LH A    
Sbjct: 332 TLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGG 391

Query: 855 HVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKI--MELLQVVPSCVASLDDVAET 909
           +V  ++LL   GA     +K  RT +  A  N     +E L    + V   DD   T
Sbjct: 392 NVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRT 448



 Score =  129 bits (324), Expect = 1e-29
 Identities = 108/412 (26%), Positives = 180/412 (43%), Gaps = 34/412 (8%)

Query: 460 DDRGHTPLHVAAVCGQASL-IDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
           ++ G TPLH AA     +L ++LLV+ GA VN     G +PLH+    G  + +  L+  
Sbjct: 244 NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQN 303

Query: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQ 578
               +  D +GNTPLH+A  YGHE  +  L     ++ +  I +     PLH+AA   + 
Sbjct: 304 GGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM---FPLHLAALNAHS 360

Query: 579 GVIETLLQNGASTEIQNRLKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAPVQSP 635
                LL +G   +  ++   T L  A    N + + ++++    F ++ K    P+   
Sbjct: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420

Query: 636 QRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEED 695
             +      E+  ++ ++++ +     T   Y          A  D++  + +L    ++
Sbjct: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHY---------AAASDMDRNKTILGNAHDN 471

Query: 696 LEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHG 755
            E+ E      + E    LC           L  +  +    ++  ++G + +H AA +G
Sbjct: 472 SEELERARELKEKE--ATLC-----------LEFLLQNDANPSIRDKEGYNSIHYAAAYG 518

Query: 756 RADLIPLLLKHGANAGARNADQAV---PLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNT 812
               + LLL+   N+G   +D      PLHLA   GH Q ++ LL S    + +D  G T
Sbjct: 519 HRQCLELLLER-TNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRT 577

Query: 813 PLIYACSGGHHELVALLLQHGASINASNN-KGNTALHEAVIEKHVFVVELLL 863
            L  A   GH E V  L+  GASI   +N    T LH +VI  H   + LLL
Sbjct: 578 ALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLL 629



 Score =  129 bits (324), Expect = 1e-29
 Identities = 120/449 (26%), Positives = 195/449 (43%), Gaps = 33/449 (7%)

Query: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
           D  G+TPLHVAA  G   LI+ L + GA       H   PLHLA    +      LL   
Sbjct: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG 370

Query: 520 ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQG 579
              +  D  G T LH A   G+ +C+K L     +  + D   + G TPLH AA   +  
Sbjct: 371 FEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD---KCGRTPLHYAAANCHFH 427

Query: 580 VIETLLQNGASTEIQNRLKETPLKCALNSKI---LSVMEAYHLSFERRQKSSEAPVQSPQ 636
            IETL+  GA+    +    T L  A  S +    +++   H + E  +++ E   +   
Sbjct: 428 CIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEAT 487

Query: 637 RSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDL 696
             ++ + Q  +  S             K+ Y  +     A A G  + +  LLE T    
Sbjct: 488 LCLEFLLQNDANPSI----------RDKEGYNSIH---YAAAYGHRQCLELLLERTNSGF 534

Query: 697 EDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGR 756
           E+++   + +      PL          + L  +  S + +++  + G + L +AA  G 
Sbjct: 535 EESDSGATKS------PL-HLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGH 587

Query: 757 ADLIPLLLKHGANAGAR-NADQAVPLHLACQQGHFQVVKCLLDSNAKP---NKKDLSGNT 812
            + +  L+  GA+   + N  +  PLH +   GH   ++ LL+    P   + KD  G T
Sbjct: 588 TECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQT 647

Query: 813 PLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVL 872
           PL+ A + GH + V+LLL+  A+++  +  G TALH  ++  H   V++LL    S+   
Sbjct: 648 PLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK 707

Query: 873 NKRQRTAVDCAEQNSK---IMELLQVVPS 898
           + R RT +  A        + ELLQ+  S
Sbjct: 708 DSRGRTPLHYAAARGHATWLSELLQMALS 736



 Score =  112 bits (281), Expect = 1e-24
 Identities = 119/439 (27%), Positives = 179/439 (40%), Gaps = 58/439 (13%)

Query: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
           D  G T LH AA+ G   +++LL++KGA +NA D      LH A   G+  V  LL+++ 
Sbjct: 112 DRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHG 171

Query: 520 ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQG 579
           A    +D  G TPLH A + G  + VK L+   VE   +D  N  G+T LHIA   G   
Sbjct: 172 AEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVE---IDEINVYGNTALHIACYNGQDA 228

Query: 580 VIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSV 639
           V+  L+  GA+    N    TPL  A  S   ++     ++       ++  +QS     
Sbjct: 229 VVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVN-----NGADVNIQSK---- 279

Query: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEM---VRYLLEWTEEDL 696
           D  S    T+     + S    +   +   V+K      DG+  +    RY  E     L
Sbjct: 280 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDK------DGNTPLHVAARYGHELLINTL 333

Query: 697 EDAEDTVSAADPEFCHPLCQCPKCAPAQKR----LAKVPASGLGVNVTSQDGSSPLHVAA 752
                  S AD   C      P    A         K+ +SG  ++   + G + LH AA
Sbjct: 334 R-----TSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAA 388

Query: 753 LHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNT 812
             G  + I LL   GA+   ++     PLH A    HF  ++ L+ + A  N+ D  G T
Sbjct: 389 AGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRT 448

Query: 813 PLIYACS----------GGHHE------------------LVALLLQHGASINASNNKGN 844
            L YA +          G  H+                   +  LLQ+ A+ +  + +G 
Sbjct: 449 ALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGY 508

Query: 845 TALHEAVIEKHVFVVELLL 863
            ++H A    H   +ELLL
Sbjct: 509 NSIHYAAAYGHRQCLELLL 527



 Score =  107 bits (267), Expect = 6e-23
 Identities = 129/491 (26%), Positives = 196/491 (39%), Gaps = 71/491 (14%)

Query: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGY-QSVTLL--- 514
           +D  G TPLH AA       I+ LV+ GA VN TD  G T LH A      ++ T+L   
Sbjct: 409 KDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNA 468

Query: 515 ------------------------LLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVY 550
                                   LL   A+  ++D  G   +H A  YGH  C++ L+ 
Sbjct: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528

Query: 551 YDVESCRLDIGNEKGD-----TPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCA 605
                 R + G E+ D     +PLH+AA  G+   +E LLQ+    +I++    T L  A
Sbjct: 529 ------RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLA 582

Query: 606 LNSKILSVMEAY----HLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQE 661
                   +EA        F +   +   P+ +       I+  +         A + + 
Sbjct: 583 AFKGHTECVEALINPGASIFVKDNVTKRTPLHA-----SVINGHTLCLRLLLEIADNPEA 637

Query: 662 ETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCA 721
              KD +    L+ AVA G ++ V  LLE      E   DTV        H         
Sbjct: 638 VDVKDAKGQTPLMLAVAYGHIDAVSLLLE-----KEANVDTVDILGCTALHRGIMTGHEE 692

Query: 722 PAQKRLAKVPASGLGVNVTSQD--GSSPLHVAALHGRADLIPLLLKHG---ANAGARNAD 776
             Q  L +       V++  +D  G +PLH AA  G A  +  LL+      +   ++  
Sbjct: 693 CVQMLLEQ------EVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQ 746

Query: 777 QAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGN--TPLIYACSGGHHELVALLLQ--H 832
              PLH AC  G+   ++ LL+       +   GN  TPL  A    H    +LLL    
Sbjct: 747 GYTPLHWACYNGNENCIEVLLEQKC---FRKFIGNPFTPLHCAIINDHGNCASLLLGAID 803

Query: 833 GASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMEL 892
            + ++  ++KG T L  A    HV  ++LLL H A V  ++   +TA+  A +N +   +
Sbjct: 804 SSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAV 863

Query: 893 LQVVPSCVASL 903
             +V S  A L
Sbjct: 864 DILVNSAQADL 874



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 107/412 (25%), Positives = 172/412 (41%), Gaps = 28/412 (6%)

Query: 440 CEKLVSGRLNDPSVVTPFSRDDRGHT--PLHVAAVCGQASLIDLLVSKGAMVNATDYHGA 497
           C +L+  R N     + F   D G T  PLH+AA  G    +++L+     ++  D  G 
Sbjct: 522 CLELLLERTN-----SGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGR 576

Query: 498 TPLHLACQKGYQSVTLLLLHYKASAEVQDN-NGNTPLHLACTYGHEDCVKALVYYDVESC 556
           T L LA  KG+      L++  AS  V+DN    TPLH +   GH  C++ L+       
Sbjct: 577 TALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPE 636

Query: 557 RLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCAL---NSKILSV 613
            +D+ + KG TPL +A  +G+   +  LL+  A+ +  + L  T L   +   + + + +
Sbjct: 637 AVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQM 696

Query: 614 MEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKL 673
           +    +S   +      P+        +    ++  S     A S ++   KD +    L
Sbjct: 697 LLEQEVSILCKDSRGRTPLHYA-----AARGHATWLSELLQMALSEEDCCFKDNQGYTPL 751

Query: 674 LRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS 733
             A  +G+   +  LLE         +   +   P  C  +     CA     L  + +S
Sbjct: 752 HWACYNGNENCIEVLLE----QKCFRKFIGNPFTPLHCAIINDHGNCASLL--LGAIDSS 805

Query: 734 GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVV 793
              V+     G +PL  AA     + + LLL+H A   A +      L +A + G    V
Sbjct: 806 I--VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAV 863

Query: 794 KCLLDS-NAKPNKKDLSGNTPLIYACSGGHHELVALLL---QHGASINASNN 841
             L++S  A    KD   NTPL  ACS GH +   L+L   Q  + IN  NN
Sbjct: 864 DILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNN 915



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 58/178 (32%), Positives = 89/178 (50%), Gaps = 4/178 (2%)

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           VN    +  +PLHVAA  G A++I LL+  GA   A++     PLH A      + V+ L
Sbjct: 9   VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 68

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
           +  +A  N +D +  TPL  A +    +   +++   +S+N S+  G TALH A +  HV
Sbjct: 69  IKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHV 128

Query: 857 FVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKEY 914
            +V LLL  GA++   +K+ R A+  A      M  L VV   +    +V   D+K Y
Sbjct: 129 EMVNLLLAKGANINAFDKKDRRALHWA----AYMGHLDVVALLINHGAEVTCKDKKGY 182



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 69/213 (32%), Positives = 99/213 (46%), Gaps = 23/213 (10%)

Query: 352 LTSFEAAIEYIRQGSLSAKPPESEGFGDRLFLKQR-----MSLLSQMTSSPTDCLFK--- 403
           +T  E  ++ + +  +S    +S G     +   R     +S L QM  S  DC FK   
Sbjct: 687 MTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQ 746

Query: 404 -----HIA--SGNQKEVERLLSQEDHDKDTVQKMCHPLCFC----DDCEKLVSGRLNDPS 452
                H A  +GN+  +E LL Q+   K          C       +C  L+ G + D S
Sbjct: 747 GYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAI-DSS 805

Query: 453 VVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQ-SV 511
           +V+   RDD+G TPL  AA       + LL+   A VNA D  G T L +A + G   +V
Sbjct: 806 IVS--CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAV 863

Query: 512 TLLLLHYKASAEVQDNNGNTPLHLACTYGHEDC 544
            +L+   +A   V+D + NTPLHLAC+ GHE C
Sbjct: 864 DILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 51/151 (33%), Positives = 72/151 (47%)

Query: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQV 792
           +G  ++   +DG++PLHVAA +G   LI  L   GA+          PLHLA    H   
Sbjct: 303 NGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDC 362

Query: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVI 852
            + LL S  + +  D  G T L  A +GG+ E + LL   GA  +  +  G T LH A  
Sbjct: 363 CRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAA 422

Query: 853 EKHVFVVELLLLHGASVQVLNKRQRTAVDCA 883
             H   +E L+  GA+V   +   RTA+  A
Sbjct: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYA 453



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 42/151 (27%), Positives = 80/151 (52%), Gaps = 1/151 (0%)

Query: 762 LLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGG 821
           +L+    +    ++++  PLH+A   G  ++++ L+ S A+ N KD    TPL  A +  
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 822 HHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVD 881
             E V +L++H A +NA +    T LH A   K V   E+++   +SV V ++  RTA+ 
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 882 CAEQNSKIMELLQVVPSCVASLDDVAETDRK 912
            A  N  + E++ ++ +  A+++   + DR+
Sbjct: 121 HAALNGHV-EMVNLLLAKGANINAFDKKDRR 150


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  131 bits (330), Expect = 3e-30
 Identities = 119/455 (26%), Positives = 194/455 (42%), Gaps = 51/455 (11%)

Query: 474 GQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGN-TP 532
           G  + +  L+ +G  VN     G + L LAC  GY  +  +LL   A+ E + N G+ TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 533 LHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTE 592
           L  A + G+ D VK L+ +D +   ++  +  G+T L  A   G+  +++ LL  GA+ E
Sbjct: 276 LMAASSGGYLDIVKLLLLHDAD---VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332

Query: 593 IQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFS 652
             N    TPL  A ++     +E   +  +     +    +  + ++     +       
Sbjct: 333 DHNENGHTPLMEAASA---GHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 389

Query: 653 SMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCH 712
            +  +   +E K D      L+ A  DG +E+ R LL        D+   V+     F  
Sbjct: 390 FLLEAGADQEHKTDEMHTA-LMEACMDGHVEVARLLL--------DSGAQVNMPADSFES 440

Query: 713 PLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGA 772
           PL     C    +  A +   G  +   + +G +PL  AA  G  +++ LLL  GAN  A
Sbjct: 441 PLTLAA-CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499

Query: 773 RNAD-QAVPLHLAC------------------------------QQGHFQVVKCLLDSNA 801
           +  + Q   L LAC                              Q+GH ++VK LL S A
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGA 559

Query: 802 KPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVEL 861
             +    +G+T L YAC  GH ++  +LLQ GA +   +  G T L +A    H+  V+ 
Sbjct: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQF 619

Query: 862 LLLHGASVQ---VLNKRQRTAVDCAEQNSKIMELL 893
           L+  GA+V      N     ++ CA  +  ++ELL
Sbjct: 620 LISKGANVNRATANNDHTVVSLACAGGHLAVVELL 654



 Score =  114 bits (284), Expect = 6e-25
 Identities = 154/567 (27%), Positives = 222/567 (39%), Gaps = 84/567 (14%)

Query: 356 EAAIEYIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVER 415
           EA +E    G LS    + + F D         +L ++TSS +  L +  A+     + R
Sbjct: 147 EALLEAAGIGKLSTA--DGKAFADP-------EVLRRLTSSVSCALDEAAAA-----LTR 192

Query: 416 LLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQ 475
           + ++  H+   V          D     V   L++   V   + +  G + L +A   G 
Sbjct: 193 MKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEE--GESLLCLACSAGY 250

Query: 476 ASLIDLLVSKGAMVNATDYHG-ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLH 534
             L  +L++  A V      G  TPL  A   GY  +  LLL + A    Q   GNT L 
Sbjct: 251 YELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALT 310

Query: 535 LACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQ 594
            AC  G  D VK L+    E   ++  NE G TPL  AA  G+  V   LL +GA     
Sbjct: 311 YACAGGFVDIVKVLLN---EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH 367

Query: 595 -NRLKETPLKCALNSKIL----------------------SVMEAY---HLSFERRQKSS 628
            N  KE+ L  A     L                      ++MEA    H+   R    S
Sbjct: 368 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS 427

Query: 629 EAPVQSPQRSVDSISQESSTSSFSSMSA------SSRQEETKKDYREVEKLLRAVADGDL 682
            A V  P  S +S    ++      ++A      ++ +E   + Y     L+ A  +G  
Sbjct: 428 GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP---LMEAAREGHE 484

Query: 683 EMVRYLLEW-------TEEDLEDAEDTV--------------SAADPEFCHPLCQCPKCA 721
           EMV  LL         TEE  E A                  + AD E     C  P   
Sbjct: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG---CSTPLME 541

Query: 722 PAQK---RLAK-VPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQ 777
            +Q+    L K + ASG  V+ T+  G + L  A  +G  D+  +LL+ GA+    +   
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 601

Query: 778 AVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGN-TPLIYACSGGHHELVALLLQHGASI 836
             PL  A + GH   V+ L+   A  N+   + + T +  AC+GGH  +V LLL HGA  
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661

Query: 837 NASNNKGNTALHEAVIEKHVFVVELLL 863
                 G+T L EA    H  VV  LL
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLL 688



 Score =  106 bits (265), Expect = 1e-22
 Identities = 105/405 (25%), Positives = 174/405 (42%), Gaps = 72/405 (17%)

Query: 526  DNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLL 585
            ++N +T L LAC  GHE+ V  L+  D    +++  ++KG TPL +AA  G+ GV+E LL
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDA---KIEHRDKKGFTPLILAATAGHVGVVEILL 1108

Query: 586  QNGASTEIQN-RLKETPLKCALNS---KILSVMEAYHLSFERRQKSSEAPVQSPQRSVDS 641
              G   E Q+ R K+TPL  A +    +++ ++ A   + E R  S   P+        S
Sbjct: 1109 DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL--------S 1160

Query: 642  ISQESSTSSFSSMSASSRQEETKKDYRE--VEKLLRAVADGDLEMVRYLLEWTEEDLEDA 699
            ++      +   +  ++  E   +   +  +  L+ A  +G +  V+ LL+         
Sbjct: 1161 LAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD--------- 1211

Query: 700  EDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQ---DGSSPLHVAALHGR 756
                                               +G ++ +Q   + ++ L +A   GR
Sbjct: 1212 -----------------------------------MGSDINAQIETNRNTALTLACFQGR 1236

Query: 757  ADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDL--SGNTPL 814
            A+++ LLL   AN   R      PL  A   G+ +V + LLD  A  N   +  S +T L
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296

Query: 815  IYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNK 874
              A   GH++   LL+  GA I+  N KGNT L  A    H  VV+LL+  GA V   + 
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356

Query: 875  RQRTAVDCAEQNSKIMELLQVV------PSCVASLDDVAETDRKE 913
            R+ T +  A +   +  +  +V      PS +  +  +A    KE
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKE 1401



 Score =  102 bits (255), Expect = 1e-21
 Identities = 97/376 (25%), Positives = 164/376 (43%), Gaps = 52/376 (13%)

Query: 492  TDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYY 551
            T+ +  T L LAC  G++ +  +L+   A  E +D  G TPL LA T GH   V+ L+  
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110

Query: 552  --DVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSK 609
              D+E+          DTPL +A   G Q V++ LL  GA+ E +N    TPL  A +  
Sbjct: 1111 GGDIEA----QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166

Query: 610  ILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYRE 669
             +++++                                      ++A +           
Sbjct: 1167 YVNIIKIL------------------------------------LNAGAEINSRTGSKLG 1190

Query: 670  VEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAK 729
            +  L+ A  +G +  V+ LL+   +     E   + A    C             + ++ 
Sbjct: 1191 ISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF--------QGRAEVVSL 1242

Query: 730  VPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGA--NAGARNADQAVPLHLACQQ 787
            +      V   ++ G +PL  AA  G A++  +LL  GA  NA    + +   L +A  +
Sbjct: 1243 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302

Query: 788  GHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTAL 847
            GH++  + L+   A  + ++  GNTPL  A +GGH ++V LL+Q GA ++A++N+  T L
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362

Query: 848  HEAVIEKHVFVVELLL 863
              A  + HV VV+ L+
Sbjct: 1363 MSAFRKGHVKVVQYLV 1378



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 102/385 (26%), Positives = 167/385 (43%), Gaps = 41/385 (10%)

Query: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNA-TDYHGATPLHLACQKGYQSVTLLLLHY 518
           ++ GHTPL  AA  G   +  +L+  GA +N  ++    + L LAC KG+  +   LL  
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA 394

Query: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQ 578
            A  E + +  +T L  AC  GH +  + L+       ++++  +  ++PL +AA  G+ 
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLD---SGAQVNMPADSFESPLTLAACGGHV 451

Query: 579 GVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRS 638
            +   L++ GA+ E  N    TPL           MEA     E       A + +   +
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPL-----------MEAAREGHEEMV----ALLLAQGAN 496

Query: 639 VDSISQESSTSSFSSMSASSRQEETK---KDYREVE-----KLLRAVADGDLEMVRYLLE 690
           +++ ++E+  ++ +        E      K   ++E      L+ A  +G LE+V+YLL 
Sbjct: 497 INAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLA 556

Query: 691 WTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPA-SGLGVNVTSQDGSSPLH 749
                  +   T +  D    +       C      +A V   +G  +   S+ G +PL 
Sbjct: 557 ----SGANVHATTATGDTALTYA------CENGHTDVADVLLQAGADLEHESEGGRTPLM 606

Query: 750 VAALHGRADLIPLLLKHGANAG--ARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKD 807
            AA  G    +  L+  GAN      N D  V + LAC  GH  VV+ LL   A P  + 
Sbjct: 607 KAARAGHLCTVQFLISKGANVNRATANNDHTV-VSLACAGGHLAVVELLLAHGADPTHRL 665

Query: 808 LSGNTPLIYACSGGHHELVALLLQH 832
             G+T LI A  GGH  +V+ LL +
Sbjct: 666 KDGSTMLIEAAKGGHTNVVSYLLDY 690



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 76/259 (29%), Positives = 119/259 (45%), Gaps = 20/259 (7%)

Query: 641 SISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAE 700
           S + + + ++ + M A +     + D R    L  A +DGD+  VR LL+      E  E
Sbjct: 180 SCALDEAAAALTRMKAENSHNAGQVDTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTE 236

Query: 701 DTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGS---SPLHVAALHGRA 757
           +  S            C  C+     LA+V  + +  NV  +      +PL  A+  G  
Sbjct: 237 EGESLL----------CLACSAGYYELAQVLLA-MHANVEDRGNKGDITPLMAASSGGYL 285

Query: 758 DLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYA 817
           D++ LLL H A+  +++A     L  AC  G   +VK LL+  A     + +G+TPL+ A
Sbjct: 286 DIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345

Query: 818 CSGGHHELVALLLQHGASINA-SNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876
            S GH E+  +LL HGA IN  SN    +AL  A  + H+ +V  LL  GA  +      
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM 405

Query: 877 RTAV--DCAEQNSKIMELL 893
            TA+   C + + ++  LL
Sbjct: 406 HTALMEACMDGHVEVARLL 424



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 78/255 (30%), Positives = 116/255 (45%), Gaps = 21/255 (8%)

Query: 636 QRSVDSISQESSTSSFSSMSASSRQEET--KKDYREVEKLLRAV-------ADG----DL 682
           Q  +D+   ++++  F S +A      T   +    +E LL A        ADG    D 
Sbjct: 110 QEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADP 169

Query: 683 EMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQ-------KRLAKVPASGL 735
           E++R L       L++A   ++    E  H   Q    + A+         + K+   G 
Sbjct: 170 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 229

Query: 736 GVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGAR-NADQAVPLHLACQQGHFQVVK 794
            VN  +++G S L +A   G  +L  +LL   AN   R N     PL  A   G+  +VK
Sbjct: 230 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 289

Query: 795 CLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEK 854
            LL  +A  N +  +GNT L YAC+GG  ++V +LL  GA+I   N  G+T L EA    
Sbjct: 290 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349

Query: 855 HVFVVELLLLHGASV 869
           HV V  +LL HGA +
Sbjct: 350 HVEVARVLLDHGAGI 364



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 92/353 (26%), Positives = 155/353 (43%), Gaps = 72/353 (20%)

Query: 459  RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNA-TDYHGATPLHLACQKGYQSVTLLLLH 517
            RD +G TPL +AA  G   ++++L+ KG  + A ++    TPL LAC  G Q V  LLL 
Sbjct: 1084 RDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLA 1143

Query: 518  YKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGY 577
              A+ E ++ +  TPL LA + G+ + +K L+    E      G++ G +PL +AA  G+
Sbjct: 1144 RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE-INSRTGSKLGISPLMLAAMNGH 1202

Query: 578  QGVIETLLQNGASTEIQ---NRLKETPLKCAL-NSKILSVMEAYHLSFERRQKSSEAPVQ 633
               ++ LL  G+    Q   NR     L C    ++++S++     + E R K+   P  
Sbjct: 1203 VPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP-- 1260

Query: 634  SPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTE 693
                                                   L+ A + G  E+ R LL+   
Sbjct: 1261 ---------------------------------------LMEAASGGYAEVGRVLLDKGA 1281

Query: 694  E----DLEDAEDT--VSAADP---EFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDG 744
            +     +  + DT    AAD    +FC  L                   G  ++V ++ G
Sbjct: 1282 DVNAPPVPSSRDTALTIAADKGHYKFCELLIH----------------RGAHIDVRNKKG 1325

Query: 745  SSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLL 797
            ++PL +A+  G  D++ LL++ GA+  A +  +  PL  A ++GH +VV+ L+
Sbjct: 1326 NTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 57/195 (29%), Positives = 91/195 (46%), Gaps = 7/195 (3%)

Query: 706  ADPEFCHPLCQCPKCAPAQKRLAKVP-ASGLGVNVTSQDGSSPLHVAALHGRADLIPLLL 764
            A  E  H       CA   + L  V  A    +    + G +PL +AA  G   ++ +LL
Sbjct: 1049 AHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILL 1108

Query: 765  KHGANAGARNA-DQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHH 823
              G +  A++   +  PL LAC  G  +VV  LL   A    +++S  TPL  A SGG+ 
Sbjct: 1109 DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV 1168

Query: 824  ELVALLLQHGASINA--SNNKGNTALHEAVIEKHVFVVELLLLHGASVQV---LNKRQRT 878
             ++ +LL  GA IN+   +  G + L  A +  HV  V+LLL  G+ +      N+    
Sbjct: 1169 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTAL 1228

Query: 879  AVDCAEQNSKIMELL 893
             + C +  ++++ LL
Sbjct: 1229 TLACFQGRAEVVSLL 1243



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 48/130 (36%), Positives = 68/130 (52%), Gaps = 5/130 (3%)

Query: 459  RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGA--TPLHLACQKGYQSVTLLLL 516
            R   G TPL  AA  G A +  +L+ KGA VNA     +  T L +A  KG+     LL+
Sbjct: 1253 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312

Query: 517  HYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWG 576
            H  A  +V++  GNTPL LA   GH D V+ LV    +   +D  + +  TPL  A R G
Sbjct: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD---VDAADNRKITPLMSAFRKG 1369

Query: 577  YQGVIETLLQ 586
            +  V++ L++
Sbjct: 1370 HVKVVQYLVK 1379



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 38/102 (37%), Positives = 50/102 (49%), Gaps = 6/102 (5%)

Query: 448  LNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKG 507
            +N P V  P SRD    T L +AA  G     +LL+ +GA ++  +  G TPL LA   G
Sbjct: 1283 VNAPPV--PSSRD----TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 1336

Query: 508  YQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALV 549
            +  V  LL+   A  +  DN   TPL  A   GH   V+ LV
Sbjct: 1337 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  131 bits (330), Expect = 3e-30
 Identities = 119/455 (26%), Positives = 194/455 (42%), Gaps = 51/455 (11%)

Query: 474 GQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGN-TP 532
           G  + +  L+ +G  VN     G + L LAC  GY  +  +LL   A+ E + N G+ TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 533 LHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTE 592
           L  A + G+ D VK L+ +D +   ++  +  G+T L  A   G+  +++ LL  GA+ E
Sbjct: 276 LMAASSGGYLDIVKLLLLHDAD---VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332

Query: 593 IQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFS 652
             N    TPL  A ++     +E   +  +     +    +  + ++     +       
Sbjct: 333 DHNENGHTPLMEAASA---GHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 389

Query: 653 SMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCH 712
            +  +   +E K D      L+ A  DG +E+ R LL        D+   V+     F  
Sbjct: 390 FLLEAGADQEHKTDEMHTA-LMEACMDGHVEVARLLL--------DSGAQVNMPADSFES 440

Query: 713 PLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGA 772
           PL     C    +  A +   G  +   + +G +PL  AA  G  +++ LLL  GAN  A
Sbjct: 441 PLTLAA-CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499

Query: 773 RNAD-QAVPLHLAC------------------------------QQGHFQVVKCLLDSNA 801
           +  + Q   L LAC                              Q+GH ++VK LL S A
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGA 559

Query: 802 KPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVEL 861
             +    +G+T L YAC  GH ++  +LLQ GA +   +  G T L +A    H+  V+ 
Sbjct: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQF 619

Query: 862 LLLHGASVQ---VLNKRQRTAVDCAEQNSKIMELL 893
           L+  GA+V      N     ++ CA  +  ++ELL
Sbjct: 620 LISKGANVNRATANNDHTVVSLACAGGHLAVVELL 654



 Score =  114 bits (284), Expect = 6e-25
 Identities = 154/567 (27%), Positives = 222/567 (39%), Gaps = 84/567 (14%)

Query: 356 EAAIEYIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVER 415
           EA +E    G LS    + + F D         +L ++TSS +  L +  A+     + R
Sbjct: 147 EALLEAAGIGKLSTA--DGKAFADP-------EVLRRLTSSVSCALDEAAAA-----LTR 192

Query: 416 LLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQ 475
           + ++  H+   V          D     V   L++   V   + +  G + L +A   G 
Sbjct: 193 MKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEE--GESLLCLACSAGY 250

Query: 476 ASLIDLLVSKGAMVNATDYHG-ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLH 534
             L  +L++  A V      G  TPL  A   GY  +  LLL + A    Q   GNT L 
Sbjct: 251 YELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALT 310

Query: 535 LACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQ 594
            AC  G  D VK L+    E   ++  NE G TPL  AA  G+  V   LL +GA     
Sbjct: 311 YACAGGFVDIVKVLLN---EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH 367

Query: 595 -NRLKETPLKCALNSKIL----------------------SVMEAY---HLSFERRQKSS 628
            N  KE+ L  A     L                      ++MEA    H+   R    S
Sbjct: 368 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS 427

Query: 629 EAPVQSPQRSVDSISQESSTSSFSSMSA------SSRQEETKKDYREVEKLLRAVADGDL 682
            A V  P  S +S    ++      ++A      ++ +E   + Y     L+ A  +G  
Sbjct: 428 GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP---LMEAAREGHE 484

Query: 683 EMVRYLLEW-------TEEDLEDAEDTV--------------SAADPEFCHPLCQCPKCA 721
           EMV  LL         TEE  E A                  + AD E     C  P   
Sbjct: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG---CSTPLME 541

Query: 722 PAQK---RLAK-VPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQ 777
            +Q+    L K + ASG  V+ T+  G + L  A  +G  D+  +LL+ GA+    +   
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 601

Query: 778 AVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGN-TPLIYACSGGHHELVALLLQHGASI 836
             PL  A + GH   V+ L+   A  N+   + + T +  AC+GGH  +V LLL HGA  
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661

Query: 837 NASNNKGNTALHEAVIEKHVFVVELLL 863
                 G+T L EA    H  VV  LL
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLL 688



 Score =  106 bits (265), Expect = 1e-22
 Identities = 105/405 (25%), Positives = 174/405 (42%), Gaps = 72/405 (17%)

Query: 526  DNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLL 585
            ++N +T L LAC  GHE+ V  L+  D    +++  ++KG TPL +AA  G+ GV+E LL
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDA---KIEHRDKKGFTPLILAATAGHVGVVEILL 1108

Query: 586  QNGASTEIQN-RLKETPLKCALNS---KILSVMEAYHLSFERRQKSSEAPVQSPQRSVDS 641
              G   E Q+ R K+TPL  A +    +++ ++ A   + E R  S   P+        S
Sbjct: 1109 DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL--------S 1160

Query: 642  ISQESSTSSFSSMSASSRQEETKKDYRE--VEKLLRAVADGDLEMVRYLLEWTEEDLEDA 699
            ++      +   +  ++  E   +   +  +  L+ A  +G +  V+ LL+         
Sbjct: 1161 LAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD--------- 1211

Query: 700  EDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQ---DGSSPLHVAALHGR 756
                                               +G ++ +Q   + ++ L +A   GR
Sbjct: 1212 -----------------------------------MGSDINAQIETNRNTALTLACFQGR 1236

Query: 757  ADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDL--SGNTPL 814
            A+++ LLL   AN   R      PL  A   G+ +V + LLD  A  N   +  S +T L
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296

Query: 815  IYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNK 874
              A   GH++   LL+  GA I+  N KGNT L  A    H  VV+LL+  GA V   + 
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356

Query: 875  RQRTAVDCAEQNSKIMELLQVV------PSCVASLDDVAETDRKE 913
            R+ T +  A +   +  +  +V      PS +  +  +A    KE
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKE 1401



 Score =  102 bits (255), Expect = 1e-21
 Identities = 97/376 (25%), Positives = 164/376 (43%), Gaps = 52/376 (13%)

Query: 492  TDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYY 551
            T+ +  T L LAC  G++ +  +L+   A  E +D  G TPL LA T GH   V+ L+  
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110

Query: 552  --DVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSK 609
              D+E+          DTPL +A   G Q V++ LL  GA+ E +N    TPL  A +  
Sbjct: 1111 GGDIEA----QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166

Query: 610  ILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYRE 669
             +++++                                      ++A +           
Sbjct: 1167 YVNIIKIL------------------------------------LNAGAEINSRTGSKLG 1190

Query: 670  VEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAK 729
            +  L+ A  +G +  V+ LL+   +     E   + A    C             + ++ 
Sbjct: 1191 ISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF--------QGRAEVVSL 1242

Query: 730  VPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGA--NAGARNADQAVPLHLACQQ 787
            +      V   ++ G +PL  AA  G A++  +LL  GA  NA    + +   L +A  +
Sbjct: 1243 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302

Query: 788  GHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTAL 847
            GH++  + L+   A  + ++  GNTPL  A +GGH ++V LL+Q GA ++A++N+  T L
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362

Query: 848  HEAVIEKHVFVVELLL 863
              A  + HV VV+ L+
Sbjct: 1363 MSAFRKGHVKVVQYLV 1378



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 102/385 (26%), Positives = 167/385 (43%), Gaps = 41/385 (10%)

Query: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNA-TDYHGATPLHLACQKGYQSVTLLLLHY 518
           ++ GHTPL  AA  G   +  +L+  GA +N  ++    + L LAC KG+  +   LL  
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA 394

Query: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQ 578
            A  E + +  +T L  AC  GH +  + L+       ++++  +  ++PL +AA  G+ 
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLD---SGAQVNMPADSFESPLTLAACGGHV 451

Query: 579 GVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRS 638
            +   L++ GA+ E  N    TPL           MEA     E       A + +   +
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPL-----------MEAAREGHEEMV----ALLLAQGAN 496

Query: 639 VDSISQESSTSSFSSMSASSRQEETK---KDYREVE-----KLLRAVADGDLEMVRYLLE 690
           +++ ++E+  ++ +        E      K   ++E      L+ A  +G LE+V+YLL 
Sbjct: 497 INAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLA 556

Query: 691 WTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPA-SGLGVNVTSQDGSSPLH 749
                  +   T +  D    +       C      +A V   +G  +   S+ G +PL 
Sbjct: 557 ----SGANVHATTATGDTALTYA------CENGHTDVADVLLQAGADLEHESEGGRTPLM 606

Query: 750 VAALHGRADLIPLLLKHGANAG--ARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKD 807
            AA  G    +  L+  GAN      N D  V + LAC  GH  VV+ LL   A P  + 
Sbjct: 607 KAARAGHLCTVQFLISKGANVNRATANNDHTV-VSLACAGGHLAVVELLLAHGADPTHRL 665

Query: 808 LSGNTPLIYACSGGHHELVALLLQH 832
             G+T LI A  GGH  +V+ LL +
Sbjct: 666 KDGSTMLIEAAKGGHTNVVSYLLDY 690



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 76/259 (29%), Positives = 119/259 (45%), Gaps = 20/259 (7%)

Query: 641 SISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAE 700
           S + + + ++ + M A +     + D R    L  A +DGD+  VR LL+      E  E
Sbjct: 180 SCALDEAAAALTRMKAENSHNAGQVDTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTE 236

Query: 701 DTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGS---SPLHVAALHGRA 757
           +  S            C  C+     LA+V  + +  NV  +      +PL  A+  G  
Sbjct: 237 EGESLL----------CLACSAGYYELAQVLLA-MHANVEDRGNKGDITPLMAASSGGYL 285

Query: 758 DLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYA 817
           D++ LLL H A+  +++A     L  AC  G   +VK LL+  A     + +G+TPL+ A
Sbjct: 286 DIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345

Query: 818 CSGGHHELVALLLQHGASINA-SNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876
            S GH E+  +LL HGA IN  SN    +AL  A  + H+ +V  LL  GA  +      
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM 405

Query: 877 RTAV--DCAEQNSKIMELL 893
            TA+   C + + ++  LL
Sbjct: 406 HTALMEACMDGHVEVARLL 424



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 78/255 (30%), Positives = 116/255 (45%), Gaps = 21/255 (8%)

Query: 636 QRSVDSISQESSTSSFSSMSASSRQEET--KKDYREVEKLLRAV-------ADG----DL 682
           Q  +D+   ++++  F S +A      T   +    +E LL A        ADG    D 
Sbjct: 110 QEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADP 169

Query: 683 EMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQ-------KRLAKVPASGL 735
           E++R L       L++A   ++    E  H   Q    + A+         + K+   G 
Sbjct: 170 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 229

Query: 736 GVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGAR-NADQAVPLHLACQQGHFQVVK 794
            VN  +++G S L +A   G  +L  +LL   AN   R N     PL  A   G+  +VK
Sbjct: 230 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 289

Query: 795 CLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEK 854
            LL  +A  N +  +GNT L YAC+GG  ++V +LL  GA+I   N  G+T L EA    
Sbjct: 290 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349

Query: 855 HVFVVELLLLHGASV 869
           HV V  +LL HGA +
Sbjct: 350 HVEVARVLLDHGAGI 364



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 92/353 (26%), Positives = 155/353 (43%), Gaps = 72/353 (20%)

Query: 459  RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNA-TDYHGATPLHLACQKGYQSVTLLLLH 517
            RD +G TPL +AA  G   ++++L+ KG  + A ++    TPL LAC  G Q V  LLL 
Sbjct: 1084 RDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLA 1143

Query: 518  YKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGY 577
              A+ E ++ +  TPL LA + G+ + +K L+    E      G++ G +PL +AA  G+
Sbjct: 1144 RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE-INSRTGSKLGISPLMLAAMNGH 1202

Query: 578  QGVIETLLQNGASTEIQ---NRLKETPLKCAL-NSKILSVMEAYHLSFERRQKSSEAPVQ 633
               ++ LL  G+    Q   NR     L C    ++++S++     + E R K+   P  
Sbjct: 1203 VPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP-- 1260

Query: 634  SPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTE 693
                                                   L+ A + G  E+ R LL+   
Sbjct: 1261 ---------------------------------------LMEAASGGYAEVGRVLLDKGA 1281

Query: 694  E----DLEDAEDT--VSAADP---EFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDG 744
            +     +  + DT    AAD    +FC  L                   G  ++V ++ G
Sbjct: 1282 DVNAPPVPSSRDTALTIAADKGHYKFCELLIH----------------RGAHIDVRNKKG 1325

Query: 745  SSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLL 797
            ++PL +A+  G  D++ LL++ GA+  A +  +  PL  A ++GH +VV+ L+
Sbjct: 1326 NTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 57/195 (29%), Positives = 91/195 (46%), Gaps = 7/195 (3%)

Query: 706  ADPEFCHPLCQCPKCAPAQKRLAKVP-ASGLGVNVTSQDGSSPLHVAALHGRADLIPLLL 764
            A  E  H       CA   + L  V  A    +    + G +PL +AA  G   ++ +LL
Sbjct: 1049 AHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILL 1108

Query: 765  KHGANAGARNA-DQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHH 823
              G +  A++   +  PL LAC  G  +VV  LL   A    +++S  TPL  A SGG+ 
Sbjct: 1109 DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV 1168

Query: 824  ELVALLLQHGASINA--SNNKGNTALHEAVIEKHVFVVELLLLHGASVQV---LNKRQRT 878
             ++ +LL  GA IN+   +  G + L  A +  HV  V+LLL  G+ +      N+    
Sbjct: 1169 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTAL 1228

Query: 879  AVDCAEQNSKIMELL 893
             + C +  ++++ LL
Sbjct: 1229 TLACFQGRAEVVSLL 1243



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 48/130 (36%), Positives = 68/130 (52%), Gaps = 5/130 (3%)

Query: 459  RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGA--TPLHLACQKGYQSVTLLLL 516
            R   G TPL  AA  G A +  +L+ KGA VNA     +  T L +A  KG+     LL+
Sbjct: 1253 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312

Query: 517  HYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWG 576
            H  A  +V++  GNTPL LA   GH D V+ LV    +   +D  + +  TPL  A R G
Sbjct: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD---VDAADNRKITPLMSAFRKG 1369

Query: 577  YQGVIETLLQ 586
            +  V++ L++
Sbjct: 1370 HVKVVQYLVK 1379



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 38/102 (37%), Positives = 50/102 (49%), Gaps = 6/102 (5%)

Query: 448  LNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKG 507
            +N P V  P SRD    T L +AA  G     +LL+ +GA ++  +  G TPL LA   G
Sbjct: 1283 VNAPPV--PSSRD----TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 1336

Query: 508  YQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALV 549
            +  V  LL+   A  +  DN   TPL  A   GH   V+ LV
Sbjct: 1337 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  130 bits (327), Expect = 6e-30
 Identities = 130/500 (26%), Positives = 205/500 (41%), Gaps = 83/500 (16%)

Query: 460 DDRGHTPLHVAAVCGQASL-IDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
           +D+G TPLHVAAV    +L ++LLV+ GA VN     G +PLH+A   G  + + +L+  
Sbjct: 269 NDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQN 328

Query: 519 KASAEVQDNNGNTPLHLACTYGHE---------------------------------DC- 544
            +  +  D  GNTPLH+A  YGHE                                 DC 
Sbjct: 329 GSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCC 388

Query: 545 ------------VKALVYYDVESCRLDIG--NEKGDTPLHIAARWGYQGVIETLLQNGAS 590
                       V +L    V S   DI   +  G T LH AA  G    +  LL +GA 
Sbjct: 389 RKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGAD 448

Query: 591 TEIQNRLKETPL---------KCAL------------NSKILSVMEAYHLSFERRQKSSE 629
              +++   TPL         +CA+            + K  S +     S   R+    
Sbjct: 449 LRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPH 508

Query: 630 APVQSPQRSVDSISQESSTSSFSSMS--ASSRQEETKKDYREVEKLLRAVADGDLEMVRY 687
            P        + + +     +F  +     +  + + +D +    +  A A G+ + +  
Sbjct: 509 TPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLEL 568

Query: 688 LLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSP 747
           LLE +   LED E T+  +          C     A K LA+   +   ++V    G + 
Sbjct: 569 LLEMSFNCLEDVESTIPVSPLHLAAYNGHCE----ALKTLAETLVN---LDVRDHKGRTA 621

Query: 748 LHVAALHGRADLIPLLLKHGANAGARNADQA-VPLHLACQQGHFQVVKCLLDSNAKPNKK 806
           L +A   G  + + +L  HGA+A  +   +   PLH A   GH   +  L+DS  + +  
Sbjct: 622 LFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADIT 681

Query: 807 DLS---GNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLL 863
           D+    G TPL+ A   GH + V LLL+ G++ +A++ +G TALH   +      +  LL
Sbjct: 682 DVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALL 741

Query: 864 LHGASVQVLNKRQRTAVDCA 883
            H A V   + + RT +  A
Sbjct: 742 DHDAFVLCRDFKGRTPIHLA 761



 Score =  127 bits (320), Expect = 4e-29
 Identities = 124/455 (27%), Positives = 188/455 (41%), Gaps = 54/455 (11%)

Query: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
           D    TPLH AA  G   ++ LL+  GA VNA D    TPLH A     + V  LLL + 
Sbjct: 38  DQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHS 97

Query: 520 ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQG 579
           A    +D    TPLH+A       C +AL         L++ +  G + LH A   G+  
Sbjct: 98  ADVNARDKLWQTPLHVAAANRATKCAEALAPL---LSSLNVADRSGRSALHHAVHSGHLE 154

Query: 580 VIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSV 639
            +  LL  GAS  + ++ +  PL  A     L V++                     R  
Sbjct: 155 TVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLL-----------------VARGA 197

Query: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGD---------LEMVRYL-L 689
           D   ++         +A+S Q E       V+ LLR  A+ D         L +  YL  
Sbjct: 198 DLGCKDRKGYGLLHTAAASGQIEV------VKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251

Query: 690 EWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLH 749
           +    +L +A   V+  + +   PL            L  +  +G  VN  S++G SPLH
Sbjct: 252 DAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLH 311

Query: 750 VAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLS 809
           +AA+HGR     +L+++G+     +     PLH+A + GH  ++  L+ + A   ++ + 
Sbjct: 312 MAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIH 371

Query: 810 GNTPLIYA-------------CSGGHHELVALL-----LQHGASINASNNKGNTALHEAV 851
              PL  A              SG  + +V+ L     L  G  IN  +N G T LH A 
Sbjct: 372 DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAA 431

Query: 852 IEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQN 886
              +V  + LLL  GA ++  +K  RT +  A  N
Sbjct: 432 SGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466



 Score =  109 bits (272), Expect = 2e-23
 Identities = 123/525 (23%), Positives = 204/525 (38%), Gaps = 87/525 (16%)

Query: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
           +D +G+  LH AA  GQ  ++  L+  GA ++  +  G T LH+AC  G  +V + L++ 
Sbjct: 202 KDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNA 261

Query: 519 KASAEVQDNNGNTPLHLACTYGHED-CVKALV-------YYDVE---------------- 554
            A+    ++ G TPLH+A    +   C++ LV       Y   E                
Sbjct: 262 GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTR 321

Query: 555 -------SCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCAL- 606
                     +D  ++ G+TPLH+AAR+G++ +I TL+ NGA T  +      PL  A+ 
Sbjct: 322 SQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVL 381

Query: 607 ------NSKILSVMEAYHLSFERRQK---SSEAPVQSPQ---RSVDSISQESSTSSFSSM 654
                   K+LS  + Y +      +   S+   + +P    R+    +         ++
Sbjct: 382 FGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNL 441

Query: 655 SASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPL 714
             SS  +  ++D      L  A A+G  +    L+         A   V+ AD + C PL
Sbjct: 442 LLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLV--------TAGAGVNEADCKGCSPL 493

Query: 715 CQCPKCAPAQKRLAKVPAS---------------------------GLGVNVTSQDGSSP 747
                    ++     P+S                           G   ++  + G + 
Sbjct: 494 HYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTA 553

Query: 748 LHVAALHGRADLIPLLLKHGANA--GARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNK 805
           +H AA +G    + LLL+   N      +     PLHLA   GH + +K L ++    + 
Sbjct: 554 VHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDV 613

Query: 806 KDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGN-TALHEAVIEKHVFVVELLLL 864
           +D  G T L  A   G  E V +L  HGAS      K   T LH A    H   + LL+ 
Sbjct: 614 RDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLID 673

Query: 865 HGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAET 909
            G    + +      +D   Q   ++ ++     CV  L +   T
Sbjct: 674 SGERADITD-----VMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713



 Score =  103 bits (257), Expect = 8e-22
 Identities = 94/339 (27%), Positives = 147/339 (43%), Gaps = 14/339 (4%)

Query: 460  DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
            D  G TPL +A + G    + LL+ KG+  +A D  G T LH     G +     LL + 
Sbjct: 685  DAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHD 744

Query: 520  ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIG-NEKGDTPLHIAARWGYQ 578
            A    +D  G TP+HLA   GH   ++ L+   + +  LD G +  G +P+H A+  G++
Sbjct: 745  AFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHE 804

Query: 579  GVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERR-QKSSEAPVQSPQR 637
              +E LL++   + ++     TPL CA+ +   S  E    +   +   S +A  ++P  
Sbjct: 805  DCLELLLEHSPFSYLEGN-PFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLH 863

Query: 638  SVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLE 697
            +       S       M    + E    D+     L+ A  +G    V +LL   + DL 
Sbjct: 864  AAAFADNVSGL----RMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLT 919

Query: 698  DAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRA 757
              ++  + A     H  C       A   LA+    GL +N T+     PLH+AA +G A
Sbjct: 920  VLDENKNTA----LHLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAARNGLA 974

Query: 758  DLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
             ++  LL HGA   A + +   P  LAC      V  CL
Sbjct: 975  SVVQALLSHGATVLAVDEEGHTPA-LACAPNK-DVADCL 1011



 Score =  103 bits (256), Expect = 1e-21
 Identities = 111/438 (25%), Positives = 185/438 (42%), Gaps = 58/438 (13%)

Query: 456 PFSRDDRGHTPLHVAAVCGQASLIDLLV--SKGAMVNATDYHGATPLHLACQKGYQSVTL 513
           P  RD +G+T +H AA  G    ++LL+  S   + +       +PLHLA   G+     
Sbjct: 543 PSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALK 602

Query: 514 LLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAA 573
            L     + +V+D+ G T L LA   G  +CV+ L  +   +   +   ++  TPLH AA
Sbjct: 603 TLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE--RKRKWTPLHAAA 660

Query: 574 RWGYQGVIETLLQNGAS---TEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEA 630
             G+   +  L+ +G     T++ +   +TPL  A+ +     ++  HL  E+   +  A
Sbjct: 661 ASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMN---GHVDCVHLLLEKGSTADAA 717

Query: 631 PVQSPQRSVDSISQESSTSSFSSMSASSRQEETK--KDYREVEKLLRAVADGDLEMVRYL 688
            +    R   ++ + + T     ++A    +     +D++    +  A A G   ++R L
Sbjct: 718 DL----RGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTL 773

Query: 689 LEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPL 748
           L+              + DP                           GV+ +   G SP+
Sbjct: 774 LQ-----------AALSTDP------------------------LDAGVDYS---GYSPM 795

Query: 749 HVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDS-NAK-PNKK 806
           H A+  G  D + LLL+H   +     +   PLH A         + LL +  AK  N +
Sbjct: 796 HWASYTGHEDCLELLLEHSPFSYLEG-NPFTPLHCAVINNQDSTTEMLLGALGAKIVNSR 854

Query: 807 DLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHG 866
           D  G TPL  A    +   + +LLQH A +NA+++ G TAL  A        VE LL  G
Sbjct: 855 DAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914

Query: 867 -ASVQVLNKRQRTAVDCA 883
            A + VL++ + TA+  A
Sbjct: 915 KADLTVLDENKNTALHLA 932



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 134/542 (24%), Positives = 206/542 (38%), Gaps = 111/542 (20%)

Query: 436 FCDDCEKLVS-GRLNDPSVVTPFSR-------------DDRGHTPLHVAAVCGQASLIDL 481
           F D C KL+S G+L   S+V+  S              D+ G T LH AA  G    ++L
Sbjct: 384 FSDCCRKLLSSGQLY--SIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNL 441

Query: 482 LVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLAC---T 538
           L+S GA +   D  G TPLH A   G     + L+   A     D  G +PLH A    T
Sbjct: 442 LLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDT 501

Query: 539 Y------------GHED-------------CVKALVYYDVESCRLDIGNEKGDTPLHIAA 573
           Y              ED             C++ L+    +    D    +G T +H AA
Sbjct: 502 YRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRD---RQGYTAVHYAA 558

Query: 574 RWGYQGVIETLLQNGAST--EIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAP 631
            +G +  +E LL+   +   ++++ +  +PL  A          AY+   E  +  +E  
Sbjct: 559 AYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA----------AYNGHCEALKTLAETL 608

Query: 632 VQSPQR------SVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMV 685
           V    R      ++   ++  ST     ++A       K+  R+   L  A A G  + +
Sbjct: 609 VNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSL 668

Query: 686 RYLLEWTEE-DLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDG 744
             L++  E  D+ D  D      P     +     C         +   G   +     G
Sbjct: 669 HLLIDSGERADITDVMDAYGQT-PLMLAIMNGHVDCVHL------LLEKGSTADAADLRG 721

Query: 745 SSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPN 804
            + LH  A+ G  D +  LL H A    R+     P+HLA   GH  V++ LL +    +
Sbjct: 722 RTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTD 781

Query: 805 KKDL----SGNTPLIYACSGGHHELVALLLQH---------------------------- 832
             D     SG +P+ +A   GH + + LLL+H                            
Sbjct: 782 PLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEM 841

Query: 833 -----GASI-NASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQN 886
                GA I N+ + KG T LH A    +V  + +LL H A V   +   RTA+  A +N
Sbjct: 842 LLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAEN 901

Query: 887 SK 888
            +
Sbjct: 902 GQ 903



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 62/155 (40%), Positives = 81/155 (52%), Gaps = 2/155 (1%)

Query: 458  SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGY-QSVTLLLL 516
            SRD +G TPLH AA     S + +L+   A VNATD+ G T L  A + G   +V  LL 
Sbjct: 853  SRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLY 912

Query: 517  HYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWG 576
              KA   V D N NT LHLAC+ GHE C   ++    +   ++  N     PLHIAAR G
Sbjct: 913  RGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNG 972

Query: 577  YQGVIETLLQNGASTEIQNRLKETP-LKCALNSKI 610
               V++ LL +GA+    +    TP L CA N  +
Sbjct: 973  LASVVQALLSHGATVLAVDEEGHTPALACAPNKDV 1007



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 90/351 (25%), Positives = 154/351 (43%), Gaps = 29/351 (8%)

Query: 545 VKALVYYDVESCR--------LDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNR 596
           V+A+   DVE  R        +++ +++  TPLH AA  G   +++ LL +GA+   ++ 
Sbjct: 13  VQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDT 72

Query: 597 LKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSS 653
           L  TPL  A    N K+L ++ A+      R K  + P+     +  +   E+     SS
Sbjct: 73  LWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSS 132

Query: 654 MSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHP 713
           ++ + R   +         L  AV  G LE V  LL        +   +++  D +   P
Sbjct: 133 LNVADRSGRSA--------LHHAVHSGHLETVNLLL--------NKGASLNVCDKKERQP 176

Query: 714 LCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGAR 773
           L         +  L  + A G  +    + G   LH AA  G+ +++  LL+ GA     
Sbjct: 177 LHWAAFLGHLEV-LKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEP 235

Query: 774 NADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPL-IYACSGGHHELVALLLQH 832
           NA     LH+AC  G   V   L+++ A  N+ +  G TPL + A S      + LL+ +
Sbjct: 236 NAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNN 295

Query: 833 GASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCA 883
           GA +N  + +G + LH A I       ++L+ +G+ +   +K   T +  A
Sbjct: 296 GADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVA 346



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 60/178 (33%), Positives = 89/178 (50%), Gaps = 4/178 (2%)

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           +NV  Q+  +PLH AA  G   ++ LLL  GAN  A++     PLH A    + +V+  L
Sbjct: 34  INVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLL 93

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
           L  +A  N +D    TPL  A +    +    L    +S+N ++  G +ALH AV   H+
Sbjct: 94  LAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHL 153

Query: 857 FVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKEY 914
             V LLL  GAS+ V +K++R  +  A      +  L+V+   VA   D+   DRK Y
Sbjct: 154 ETVNLLLNKGASLNVCDKKERQPLHWA----AFLGHLEVLKLLVARGADLGCKDRKGY 207



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 67/233 (28%), Positives = 104/233 (44%), Gaps = 10/233 (4%)

Query: 673 LLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPA 732
           L++A+   D+E VR LL   E         ++  D E   PL            L  +  
Sbjct: 12  LVQAIFSRDVEEVRSLLSQKEN--------INVLDQERRTPLHAAAYVGDVPI-LQLLLM 62

Query: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQV 792
           SG  VN       +PLH AA      ++ LLL H A+  AR+     PLH+A      + 
Sbjct: 63  SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKC 122

Query: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVI 852
            + L    +  N  D SG + L +A   GH E V LLL  GAS+N  + K    LH A  
Sbjct: 123 AEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAF 182

Query: 853 EKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDD 905
             H+ V++LL+  GA +   +++    +  A  + +I E+++ +    A +D+
Sbjct: 183 LGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQI-EVVKYLLRMGAEIDE 234



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 50/148 (33%), Positives = 64/148 (43%), Gaps = 3/148 (2%)

Query: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLH 517
           +RD    TPLHVAA        + L    + +N  D  G + LH A   G+     LLL+
Sbjct: 102 ARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLN 161

Query: 518 YKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGY 577
             AS  V D     PLH A   GH + +K LV        L   + KG   LH AA  G 
Sbjct: 162 KGASLNVCDKKERQPLHWAAFLGHLEVLKLLV---ARGADLGCKDRKGYGLLHTAAASGQ 218

Query: 578 QGVIETLLQNGASTEIQNRLKETPLKCA 605
             V++ LL+ GA  +  N    T L  A
Sbjct: 219 IEVVKYLLRMGAEIDEPNAFGNTALHIA 246



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 62/210 (29%), Positives = 95/210 (45%), Gaps = 6/210 (2%)

Query: 387 MSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSG 446
           M +LS     P   L + I S + +EV  LLSQ+++     Q+   PL        +   
Sbjct: 1   MGILSITDQPP---LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPIL 57

Query: 447 RLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQK 506
           +L   S     ++D    TPLH AA      ++ LL++  A VNA D    TPLH+A   
Sbjct: 58  QLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAAN 117

Query: 507 GYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGD 566
                   L    +S  V D +G + LH A   GH + V  L+    +   L++ ++K  
Sbjct: 118 RATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLN---KGASLNVCDKKER 174

Query: 567 TPLHIAARWGYQGVIETLLQNGASTEIQNR 596
            PLH AA  G+  V++ L+  GA    ++R
Sbjct: 175 QPLHWAAFLGHLEVLKLLVARGADLGCKDR 204


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  130 bits (327), Expect = 6e-30
 Identities = 124/454 (27%), Positives = 187/454 (41%), Gaps = 62/454 (13%)

Query: 441 EKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPL 500
           EK+++  L  P  V   + D R  TPLH+AA   +  ++ LL+  GA V+A D     PL
Sbjct: 191 EKMMA--LLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPL 248

Query: 501 HLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDI 560
           H AC  G+  VT LL+ + A     D    TPLH A +    +    L+ Y  +   L+ 
Sbjct: 249 HNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNC 308

Query: 561 GNEKG----DTPLHIAARWGYQGVIETLLQNGASTEIQNRLK---------------ETP 601
            N+       TP  +  R  Y+    +LLQ     ++    K               ET 
Sbjct: 309 HNKSAIDLAPTP-QLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETA 367

Query: 602 LKCALNS------KILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMS 655
           L CA  S      +I  ++     +   + K    P+         ++ E + +    + 
Sbjct: 368 LHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLH--------VASEKAHNDVVEVV 419

Query: 656 ASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEW------------------TEEDLE 697
                +    D      L RA   G L+  R LL +                   E   +
Sbjct: 420 VKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQ 479

Query: 698 DAEDTVSAADPEFCHPLCQCPKCAPAQ--KRLAKVPASGLGVNVTSQDG--SSPLHVAAL 753
             ++ +S  + E    L +  K    +  K+L  V +    VN    +G  S+PLH AA 
Sbjct: 480 LLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQS----VNCRDIEGRQSTPLHFAAG 535

Query: 754 HGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTP 813
           + R  ++  LL+HGA+  A++    VPLH AC  GH++V + L+   A  N  DL   TP
Sbjct: 536 YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTP 595

Query: 814 LIYACSGGHHELVALLLQHGASINASNNKGNTAL 847
           L  A + G +E+  LLLQHGA     N  GNT L
Sbjct: 596 LHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL 629



 Score =  108 bits (271), Expect = 2e-23
 Identities = 116/431 (26%), Positives = 170/431 (39%), Gaps = 46/431 (10%)

Query: 457 FSRDDRGHTPLHVAAVCG---QASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTL 513
           F       T LH AA      +  + +LL+ KGA +N       TPLH+A +K +  V  
Sbjct: 358 FKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVE 417

Query: 514 LLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESC----------------- 556
           +++ ++A     DN G T LH A   GH    + L+ Y  +                   
Sbjct: 418 VVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENV 477

Query: 557 ------RLDIGNEKGDTPLHIAARWGYQGVIETL--LQNGASTEIQNRLKETPLKCALNS 608
                  + +GN + D  L  AA+ G    ++ L  +Q+    +I+ R + TPL  A   
Sbjct: 478 QQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGR-QSTPLHFAAGY 536

Query: 609 KILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYR 668
             +SV+E Y L       + +     P  +  S              A     +  K   
Sbjct: 537 NRVSVVE-YLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWK--- 592

Query: 669 EVEKLLRAVADGDLEMVRYLLEWTEE------DLEDAEDTVSAADPEFCHPLCQCPKCAP 722
               L  A A G  E+ + LL+   +      D     D V   D +    L        
Sbjct: 593 -FTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLD 651

Query: 723 AQKR--LAKVPASGLGVNVTSQDG----SSPLHVAALHGRADLIPLLLKHGANAGARNAD 776
           A K+  LA+V       NV  +D     S+PLH+AA +   ++   LL+HGA+  A++  
Sbjct: 652 AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711

Query: 777 QAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASI 836
             +PLH A   GH  V   L+  NA  N  D    TPL  A   G  +L ALLL HGA  
Sbjct: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771

Query: 837 NASNNKGNTAL 847
              N +G T L
Sbjct: 772 TLKNQEGQTPL 782



 Score =  104 bits (259), Expect = 5e-22
 Identities = 131/551 (23%), Positives = 199/551 (36%), Gaps = 118/551 (21%)

Query: 447 RLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQK 506
           RL  P  V       R  TPLH AA  G+  +++ L+  GA V A D  G  PLH AC  
Sbjct: 42  RLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSF 101

Query: 507 GYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE--------SCRL 558
           G+  V  LLL + A    +DN   TPLH A   G  D    L+ +  E           L
Sbjct: 102 GHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTAL 161

Query: 559 DI------------------------GNE-------------------KGDTPLHIAARW 575
           D+                        GNE                   +  TPLH+AA +
Sbjct: 162 DLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGY 221

Query: 576 GYQGVIETLLQNGASTEIQNRLKETPLKCAL-------------NSKILSVMEAYHLS-F 621
               +++ LLQ+GA    +++    PL  A              +   ++ M+ +  +  
Sbjct: 222 NRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPL 281

Query: 622 ERRQKSSEAPVQSPQRS--VDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVAD 679
                 +   V S   S   D         S   ++ + + +E      +   LL+A  +
Sbjct: 282 HEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAARE 341

Query: 680 GDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKR---LAKVPASGLG 736
            D+  ++  L         + + V+   P+       C   +P  KR      +   G  
Sbjct: 342 ADVTRIKKHL---------SLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGAN 392

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           +N  +++  +PLHVA+     D++ +++KH A   A +      LH A   GH Q  + L
Sbjct: 393 INEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINAS----------------- 839
           L     PN   L G T L        +E V  LLQ G S+  S                 
Sbjct: 453 LSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGNSEADRQLLEAAKAGDVET 507

Query: 840 ---------------NNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVD--C 882
                            + +T LH A     V VVE LL HGA V   +K     +   C
Sbjct: 508 VKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNAC 567

Query: 883 AEQNSKIMELL 893
           +  + ++ ELL
Sbjct: 568 SYGHYEVAELL 578



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 110/458 (24%), Positives = 172/458 (37%), Gaps = 82/458 (17%)

Query: 498 TPLHLACQKGY---QSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE 554
           T LH A    Y   + +  LLL   A+   +     TPLH+A    H D V+ +V ++ +
Sbjct: 366 TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK 425

Query: 555 SCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVM 614
              LD     G T LH AA  G+      LL  G    I +    T L+   N  +  ++
Sbjct: 426 VNALD---NLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG-NENVQQLL 481

Query: 615 EAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLL 674
           +   +S    +   +    +    V+++ +  +  S +      RQ            L 
Sbjct: 482 QE-GISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTP---------LH 531

Query: 675 RAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS- 733
            A     + +V YLL+   +        V A D     PL     C+     +A++    
Sbjct: 532 FAAGYNRVSVVEYLLQHGAD--------VHAKDKGGLVPLHNA--CSYGHYEVAELLVKH 581

Query: 734 GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGA------------------------- 768
           G  VNV      +PLH AA  G+ ++  LLL+HGA                         
Sbjct: 582 GAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQD 641

Query: 769 ---------------------------NAGARNAD--QAVPLHLACQQGHFQVVKCLLDS 799
                                      N   R+     + PLHLA    + +V + LL  
Sbjct: 642 LLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQH 701

Query: 800 NAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVV 859
            A  N +D  G  PL  A S GH ++ ALL+++ A +NA++    T LHEA  +    + 
Sbjct: 702 GADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLC 761

Query: 860 ELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVP 897
            LLL HGA   + N+  +T +D    +     L   +P
Sbjct: 762 ALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMP 799



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 83/321 (25%), Positives = 123/321 (38%), Gaps = 37/321 (11%)

Query: 489 VNATDYHG--ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVK 546
           VN  D  G  +TPLH A      SV   LL + A    +D  G  PLH AC+YGH +  +
Sbjct: 517 VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE 576

Query: 547 ALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCAL 606
            LV +      +++ +    TPLH AA  G   + + LLQ+GA    +NR   TPL    
Sbjct: 577 LLVKHGAV---VNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV- 632

Query: 607 NSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETK-- 664
                              K  +  +Q   R   ++   +     + +   S  +     
Sbjct: 633 -------------------KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCR 673

Query: 665 -KDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPA 723
               R    L  A    +LE+  YLL+   +        V+A D     PL         
Sbjct: 674 DTQGRHSTPLHLAAGYNNLEVAEYLLQHGAD--------VNAQDKGGLIPLHNAASYGHV 725

Query: 724 QKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHL 783
                 +  +   VN T +   +PLH AA  GR  L  LLL HGA+   +N +   PL L
Sbjct: 726 DVAALLIKYNAC-VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784

Query: 784 ACQQGHFQVVKCLLDSNAKPN 804
                   ++   +  +A P+
Sbjct: 785 VSADDVSALLTAAMPPSALPS 805



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 61/194 (31%), Positives = 92/194 (47%), Gaps = 25/194 (12%)

Query: 736 GVNVTSQD--GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVV 793
           G NV ++D  G  PLH A   G A+++ LLL+HGA+  AR+     PLH A  +G   V 
Sbjct: 81  GANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVC 140

Query: 794 KCLLDSNAKPNKKDLSGNTPLIY---------------------ACSGGHHELVALLLQH 832
             LL   A+P  ++  G T L                       A SG   +++ALL   
Sbjct: 141 IVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPL 200

Query: 833 GASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVD--CAEQNSKIM 890
             + +AS+ + +T LH A     V +V+LLL HGA V   +K     +   C+  + ++ 
Sbjct: 201 NVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVT 260

Query: 891 ELLQVVPSCVASLD 904
           ELL    +CV ++D
Sbjct: 261 ELLVKHGACVNAMD 274



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 81/265 (30%), Positives = 110/265 (41%), Gaps = 38/265 (14%)

Query: 374 SEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLL-SQEDHDKDTVQKMCH 432
           S G    +   Q  + L     +    L + I+ GN +   +LL + +  D +TV+K+C 
Sbjct: 454 SYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCT 513

Query: 433 PLCF-CDDCEKLVSGRL------NDPSVVTPF--------SRDDRGHTPLHVAAVCGQAS 477
                C D E   S  L      N  SVV           ++D  G  PLH A   G   
Sbjct: 514 VQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYE 573

Query: 478 LIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHL-- 535
           + +LLV  GA+VN  D    TPLH A  KG   +  LLL + A    ++ +GNTPL L  
Sbjct: 574 VAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVK 633

Query: 536 ------------------ACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGY 577
                             A   G    VK L   D  +CR   G  +  TPLH+AA +  
Sbjct: 634 DGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQG--RHSTPLHLAAGYNN 691

Query: 578 QGVIETLLQNGASTEIQNRLKETPL 602
             V E LLQ+GA    Q++    PL
Sbjct: 692 LEVAEYLLQHGADVNAQDKGGLIPL 716



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 71/251 (28%), Positives = 111/251 (44%), Gaps = 45/251 (17%)

Query: 456 PFSRDDRGHTPLHVAA---------VCGQASLIDLLVSKGAM-----------VNATDYH 495
           P  ++  G+TPL +           + G A+L+D    KG +           VN  D  
Sbjct: 618 PTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDA-AKKGCLARVKKLSSPDNVNCRDTQ 676

Query: 496 G--ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDV 553
           G  +TPLHLA       V   LL + A    QD  G  PLH A +YGH D    L+ Y+ 
Sbjct: 677 GRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN- 735

Query: 554 ESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSV 613
            +C ++  ++   TPLH AA+ G   +   LL +GA   ++N+  +TPL       + ++
Sbjct: 736 -AC-VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSAL 793

Query: 614 MEAYHLSFERRQKSSEAP----------VQSPQRSVDSISQESSTSSFSSMSASSRQEET 663
           + A           S  P          V+SP  + D++S  S  SS SS+SA+S  +  
Sbjct: 794 LTA-------AMPPSALPSCYKPQVLNGVRSPGATADALS--SGPSSPSSLSAASSLDNL 844

Query: 664 KKDYREVEKLL 674
              + E+  ++
Sbjct: 845 SGSFSELSSVV 855



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 106/445 (23%), Positives = 178/445 (40%), Gaps = 66/445 (14%)

Query: 497 ATPLHLACQKG-YQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVES 555
           A  L  AC+ G  + V  L+   K ++       +TPLH A  +G +D V+ L+      
Sbjct: 25  ARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQ---NG 81

Query: 556 CRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPL-KCALNSKILSVM 614
             +   ++ G  PLH A  +G+  V+  LL++GA    ++    TPL + A+  KI    
Sbjct: 82  ANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKI---- 137

Query: 615 EAYHLSFERRQKSSEAPVQSPQ-RSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKL 673
               +     Q  +E  +++   R+   ++  S+ +  +         E KKD     +L
Sbjct: 138 ---DVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTG--------EYKKD-----EL 181

Query: 674 LRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVP-- 731
           L +   G+ E +  L       L        A+D     PL      A    R+  V   
Sbjct: 182 LESARSGNEEKMMAL-------LTPLNVNCHASDGRKSTPL----HLAAGYNRVKIVQLL 230

Query: 732 -ASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHF 790
              G  V+   +    PLH A  +G  ++  LL+KHGA   A +  Q  PLH A  +   
Sbjct: 231 LQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRV 290

Query: 791 QVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVAL------LLQHGASINASNNKGN 844
           +V   LL   A P   +    + +  A +    E +A       LLQ     + +  K +
Sbjct: 291 EVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKH 350

Query: 845 ---------------TALHEAVIE---KHVFVVELLLLHGASVQVLNKRQRTAVDCAEQ- 885
                          TALH A      K   + ELLL  GA++    K   T +  A + 
Sbjct: 351 LSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEK 410

Query: 886 -NSKIMELLQVVPSCVASLDDVAET 909
            ++ ++E++    + V +LD++ +T
Sbjct: 411 AHNDVVEVVVKHEAKVNALDNLGQT 435



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 44/125 (35%), Positives = 62/125 (49%), Gaps = 4/125 (3%)

Query: 768 ANAGARNADQAV-PLHLACQQGHFQVVKCLLDSNAKPNKKDLSG--NTPLIYACSGGHHE 824
           A+A A   + A   L  AC+ G  + VK L+    K N +D +G  +TPL +A   G  +
Sbjct: 14  ASAAAEAVEPAARELFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKD 72

Query: 825 LVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAE 884
           +V  LLQ+GA++ A ++ G   LH A    H  VV LLL HGA     +    T +  A 
Sbjct: 73  VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132

Query: 885 QNSKI 889
              KI
Sbjct: 133 IKGKI 137


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  129 bits (323), Expect = 2e-29
 Identities = 124/452 (27%), Positives = 186/452 (41%), Gaps = 58/452 (12%)

Query: 441 EKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPL 500
           EKL++  L  P  V   + D R  TPLH+AA   +  ++ LL+  GA V+A D  G  PL
Sbjct: 349 EKLMA--LLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPL 406

Query: 501 HLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE----SC 556
           H AC  G+  VT LLL + A     D    TPLH A +    +    L+ +  +    +C
Sbjct: 407 HNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNC 466

Query: 557 RLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEI---------------QNRLKETP 601
                 +   TP  +  R  Y+    +LLQ     ++               Q +  ET 
Sbjct: 467 HGKSAVDMAPTP-ELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETA 525

Query: 602 LKCALNS------KILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMS 655
           L CA+ S      ++  ++     +   + K    P+        +   E      + M+
Sbjct: 526 LHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN 585

Query: 656 ASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDL--------------EDAED 701
           A     +T         L RA   G L+  R LL +  +                E  + 
Sbjct: 586 ALDTLGQTA--------LHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQ 637

Query: 702 TVSAADP----EFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDG--SSPLHVAALHG 755
            +S + P    +  + L +  K    +    K   S   VN    +G  S+PLH AA + 
Sbjct: 638 ILSESTPIRTSDVDYRLLEASKAGDLET--VKQLCSSQNVNCRDLEGRHSTPLHFAAGYN 695

Query: 756 RADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLI 815
           R  ++  LL HGA+  A++    VPLH AC  GH++V + L+   A  N  DL   TPL 
Sbjct: 696 RVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLH 755

Query: 816 YACSGGHHELVALLLQHGASINASNNKGNTAL 847
            A + G +E+  LLL+HGA     N  GNT L
Sbjct: 756 EAAAKGKYEICKLLLKHGADPTKKNRDGNTPL 787



 Score =  106 bits (264), Expect = 1e-22
 Identities = 132/489 (26%), Positives = 193/489 (39%), Gaps = 89/489 (18%)

Query: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLH 517
           ++D  G  PLH A   G   + +LL+  GA VNA D    TPLH A  K    V  LLL 
Sbjct: 397 AKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLS 456

Query: 518 YKASAEVQDNNGNTPLHLACT-----------YGHEDCVKALVYYDVESCR----LDIGN 562
           + A   + + +G + + +A T            GH   ++A    D+   +    L+I N
Sbjct: 457 HGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHS-LLQAAREADLAKVKKTLALEIIN 515

Query: 563 EKG----DTPLHIAARWGY---QGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVME 615
            K     +T LH A    +   + V E LL+ GA+   +N+   TPL  A       VME
Sbjct: 516 FKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVME 575

Query: 616 AYH-----------LSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETK 664
             H           L      +++ A      R + S   + S  S    +A+    E  
Sbjct: 576 VLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAV 635

Query: 665 K--------------DYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEF 710
           +              DYR    LL A   GDLE V+ L      +  D E   S      
Sbjct: 636 QQILSESTPIRTSDVDYR----LLEASKAGDLETVKQLCSSQNVNCRDLEGRHST----- 686

Query: 711 CHPLCQCPKCAPAQKRLAKVPA---SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHG 767
             PL      A    R++ V      G  V+   + G  PLH A  +G  ++  LL++HG
Sbjct: 687 --PL----HFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHG 740

Query: 768 ANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVA 827
           A+    +  +  PLH A  +G +++ K LL   A P KK+  GNTPL      G  ++  
Sbjct: 741 ASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQD 799

Query: 828 LLLQHGASINASNN----------------------KGNTALHEAVIEKHVFVVELLLLH 865
           LL    A ++A+                        + +T LH A    ++ V E LL H
Sbjct: 800 LLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEH 859

Query: 866 GASVQVLNK 874
           GA V   +K
Sbjct: 860 GADVNAQDK 868



 Score =  103 bits (256), Expect = 1e-21
 Identities = 134/555 (24%), Positives = 199/555 (35%), Gaps = 139/555 (25%)

Query: 447 RLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQK 506
           RL D + V       R  +PLH AA  G+  +++ L+  GA V+A D  G  PLH AC  
Sbjct: 200 RLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSF 259

Query: 507 GYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE--------SCRL 558
           G+  V  LLL   A    +DN   TPLH A   G  D    L+ +  +           L
Sbjct: 260 GHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSAL 319

Query: 559 DI------------------------GNE-------------------KGDTPLHIAARW 575
           D+                        GNE                   +  TPLH+AA +
Sbjct: 320 DLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGY 379

Query: 576 GYQGVIETLLQNGASTEIQNRLKETPLKCAL-------------NSKILSVMEAYHLS-- 620
               +++ LLQ+GA    +++    PL  A              +   ++ M+ +  +  
Sbjct: 380 NRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPL 439

Query: 621 FERRQKSS-EAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVAD 679
            E   K+  E          D         S   M+ +    E      +   LL+A  +
Sbjct: 440 HEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAARE 499

Query: 680 GDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCA--PAQKRLAK-VPASGLG 736
            DL  V+  L         A + ++   P+       C   +  P +K++ + +   G  
Sbjct: 500 ADLAKVKKTL---------ALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGAN 550

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           VN  ++D  +PLHVAA     D++ +L KHGA   A +      LH A   GH Q  + L
Sbjct: 551 VNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610

Query: 797 LDSNAKPN-----------------KKDLSGNTP---------LIYACSGGHHELVALL- 829
           L   + P+                 ++ LS +TP         L+ A   G  E V  L 
Sbjct: 611 LSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLC 670

Query: 830 ---------------------------------LQHGASINASNNKGNTALHEAVIEKHV 856
                                            L HGA ++A +  G   LH A    H 
Sbjct: 671 SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHY 730

Query: 857 FVVELLLLHGASVQV 871
            V ELL+ HGASV V
Sbjct: 731 EVAELLVRHGASVNV 745



 Score =  102 bits (255), Expect = 1e-21
 Identities = 109/418 (26%), Positives = 162/418 (38%), Gaps = 60/418 (14%)

Query: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
           TPLHVAA      ++++L   GA +NA D  G T LH A   G+     LLL Y +   +
Sbjct: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619

Query: 525 QDNNG-----------------NTPLHL---------ACTYGHEDCVKALVYYDVESCRL 558
               G                 +TP+           A   G  + VK L      +CR 
Sbjct: 620 ISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRD 679

Query: 559 DIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNS---KILSVME 615
             G     TPLH AA +    V+E LL +GA    +++    PL  A +    ++  ++ 
Sbjct: 680 LEGRHS--TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLV 737

Query: 616 AYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLR 675
            +  S          P+          +          +      + TKK+ R+    L 
Sbjct: 738 RHGASVNVADLWKFTPLHE--------AAAKGKYEICKLLLKHGADPTKKN-RDGNTPLD 788

Query: 676 AVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGL 735
            V +GD + ++ LL      L+ A+    A   + C P  +   C   Q R         
Sbjct: 789 LVKEGDTD-IQDLLRGDAALLDAAKKGCLARVQKLCTP--ENINCRDTQGR--------- 836

Query: 736 GVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKC 795
                    S+PLH+AA +   ++   LL+HGA+  A++    +PLH A   GH  +   
Sbjct: 837 --------NSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAAL 888

Query: 796 LLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIE 853
           L+  N   N  D    TPL  A   G  +L ALLL HGA     N +G T L  A  +
Sbjct: 889 LIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD 946



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 124/480 (25%), Positives = 187/480 (38%), Gaps = 93/480 (19%)

Query: 474 GQASLIDLLVSKGAMVNATDYHG--ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNT 531
           G  S +  LV   A VNA D  G  ++PLH A   G + V   LL   A+   +D+ G  
Sbjct: 193 GDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLI 251

Query: 532 PLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGAST 591
           PLH AC++GH + V  L+    +    D  N    TPLH AA  G   V   LLQ+GA  
Sbjct: 252 PLHNACSFGHAEVVSLLLCQGADPNARDNWNY---TPLHEAAIKGKIDVCIVLLQHGADP 308

Query: 592 EIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSF 651
            I+N   ++ L  A  S    +   Y     ++ +  EA     +  + ++    + +  
Sbjct: 309 NIRNTDGKSALDLADPSAKAVLTGEY-----KKDELLEAARSGNEEKLMALLTPLNVNCH 363

Query: 652 SSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFC 711
           +S            D R+   L  A     + +V+ LL+   +        V A D    
Sbjct: 364 AS------------DGRKSTPLHLAAGYNRVRIVQLLLQHGAD--------VHAKDKGGL 403

Query: 712 HPLCQCPKCAPAQKRLAKVPAS-GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANA 770
            PL     C+     + ++    G  VN       +PLH AA   R ++  LLL HGA+ 
Sbjct: 404 VPLHNA--CSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADP 461

Query: 771 ----------------------------------GARNADQA------------------ 778
                                              AR AD A                  
Sbjct: 462 TLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQS 521

Query: 779 --VPLHLACQQGH---FQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHG 833
               LH A    H    QV + LL   A  N+K+    TPL  A    H++++ +L +HG
Sbjct: 522 HETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG 581

Query: 834 ASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELL 893
           A +NA +  G TALH A +  H+    LLL +G+   +++ +  TA      N  + ++L
Sbjct: 582 AKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMG--NEAVQQIL 639



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 97/353 (27%), Positives = 146/353 (41%), Gaps = 71/353 (20%)

Query: 503 ACQKGYQSVTLLLLHYKASAEVQDNNG--NTPLHLACTYGHEDCVKALVYYDVESCRLDI 560
           AC+ G  S    L+   A+   +D  G  ++PLH A  +G +D V+ L+         D 
Sbjct: 189 ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 247

Query: 561 GNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPL-KCALNSKILSVMEAYHL 619
           G   G  PLH A  +G+  V+  LL  GA    ++    TPL + A+  KI         
Sbjct: 248 G---GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKI--------- 295

Query: 620 SFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVAD 679
                    +  +   Q   D   + +   S   ++  S +     +Y++ ++LL A   
Sbjct: 296 ---------DVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK-DELLEAARS 345

Query: 680 GDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNV 739
           G+ E +  LL                                           + L VN 
Sbjct: 346 GNEEKLMALL-------------------------------------------TPLNVNC 362

Query: 740 TSQDG--SSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLL 797
            + DG  S+PLH+AA + R  ++ LLL+HGA+  A++    VPLH AC  GH++V + LL
Sbjct: 363 HASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLL 422

Query: 798 DSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEA 850
              A  N  DL   TPL  A S    E+ +LLL HGA     N  G +A+  A
Sbjct: 423 KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 62/179 (34%), Positives = 90/179 (50%), Gaps = 5/179 (2%)

Query: 714 LCQCPKCAPAQKRLAKVP-ASGLGVNVTSQDGS-SPLHVAALHGRADLIPLLLKHGANAG 771
           L + P+ A         P A+G G  V +  G+   L  A  +G    +  L+   AN  
Sbjct: 150 LAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVD-AANVN 208

Query: 772 ARN--ADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALL 829
           A++    ++ PLH A   G   VV+ LL   A  + +D  G  PL  ACS GH E+V+LL
Sbjct: 209 AKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLL 268

Query: 830 LQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSK 888
           L  GA  NA +N   T LHEA I+  + V  +LL HGA   + N   ++A+D A+ ++K
Sbjct: 269 LCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK 327



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 66/225 (29%), Positives = 101/225 (44%), Gaps = 32/225 (14%)

Query: 456 PFSRDDRGHTPLHVAA---------VCGQASLIDLLVSKGAM-----------VNATDYH 495
           P  ++  G+TPL +           + G A+L+D    KG +           +N  D  
Sbjct: 776 PTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDA-AKKGCLARVQKLCTPENINCRDTQ 834

Query: 496 G--ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDV 553
           G  +TPLHLA       V   LL + A    QD  G  PLH A +YGH D    L+ Y+ 
Sbjct: 835 GRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYN- 893

Query: 554 ESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSV 613
            +C ++  ++   TPLH AA+ G   +   LL +GA   ++N+  +TPL  A    I ++
Sbjct: 894 -TC-VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRAL 951

Query: 614 MEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASS 658
           +       +     +      PQ +V S S  S  S+ S +SA+S
Sbjct: 952 L------IDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAAS 990



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 54/165 (32%), Positives = 73/165 (44%), Gaps = 22/165 (13%)

Query: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLH 517
           ++D  G  PLH A   G   + +LLV  GA VN  D    TPLH A  KG   +  LLL 
Sbjct: 712 AKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLK 771

Query: 518 YKASAEVQDNNGNTPLHL--------------------ACTYGHEDCVKALVYYDVESCR 557
           + A    ++ +GNTPL L                    A   G    V+ L   +  +CR
Sbjct: 772 HGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCR 831

Query: 558 LDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPL 602
              G  +  TPLH+AA +    V E LL++GA    Q++    PL
Sbjct: 832 DTQG--RNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPL 874



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 39/126 (30%), Positives = 55/126 (43%), Gaps = 3/126 (2%)

Query: 447 RLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQK 506
           +L  P  +       R  TPLH+AA      + + L+  GA VNA D  G  PLH A   
Sbjct: 821 KLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASY 880

Query: 507 GYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGD 566
           G+  +  LL+ Y       D    TPLH A   G       L+ +  +     + N++G 
Sbjct: 881 GHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP---TMKNQEGQ 937

Query: 567 TPLHIA 572
           TPL +A
Sbjct: 938 TPLDLA 943



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 39/108 (36%), Positives = 56/108 (51%), Gaps = 3/108 (2%)

Query: 784 ACQQGHFQVVKCLLDSNAKPNKKDLSG--NTPLIYACSGGHHELVALLLQHGASINASNN 841
           AC+ G    VK L+D+ A  N KD++G  ++PL +A   G  ++V  LLQ GA+++A ++
Sbjct: 189 ACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 247

Query: 842 KGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKI 889
            G   LH A    H  VV LLL  GA     +    T +  A    KI
Sbjct: 248 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKI 295


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  129 bits (323), Expect = 2e-29
 Identities = 153/547 (27%), Positives = 214/547 (39%), Gaps = 69/547 (12%)

Query: 356 EAAIEYIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVER 415
           EA +E    G LS    + + F D         +L ++TSS +  L +  A+  +   E 
Sbjct: 176 EALLEAAGIGKLSTA--DGKAFADP-------EVLRRLTSSVSCALDEAAAALTRMRAES 226

Query: 416 LLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQ 475
             +    D  ++ + C         + L+ GR  +          + G + L +A   G 
Sbjct: 227 TANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVN-------EHTEEGESLLCLACSAGY 279

Query: 476 ASLIDLLVSKGAMVNATDYHG-ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLH 534
             L  +L++  A V      G  TPL  A   G+  +  LLL +KA    Q + GNT L 
Sbjct: 280 YELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALT 339

Query: 535 LACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQ 594
            AC  G+ D VK L+        ++  NE G TPL  A   G+  V   LL+NGA     
Sbjct: 340 YACAGGYVDVVKVLLE---SGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH 396

Query: 595 -NRLKETPLKCALNSKIL----------------------SVMEAY---HLSFERRQKSS 628
            N  KE+ L  A     L                      ++MEA    H+   R    S
Sbjct: 397 SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS 456

Query: 629 EAPVQSPQRSVDSISQESSTSSFSSMSA------SSRQEETKKDYREVEKLLRAVADGDL 682
            A V  P  S +S    ++      ++A      +S +E   + Y     L+ A  +G  
Sbjct: 457 GAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTP---LMEAAREGHE 513

Query: 683 EMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS-GLGVNVTS 741
           EMV  LL          E+T   A    C     C         L K  A   LG     
Sbjct: 514 EMVALLLGQGANINAQTEETQETALTLAC-----CGGFLEVADFLIKAGADIELGC---- 564

Query: 742 QDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNA 801
              S+PL  AA  G  +L+  LL  GAN  A  A     L  AC+ GH  V   LL + A
Sbjct: 565 ---STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGA 621

Query: 802 KPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASN-NKGNTALHEAVIEKHVFVVE 860
               +   G TPL+ A   GH   V  L+  GA++N +  N  +T L  A    H+ VVE
Sbjct: 622 DLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE 681

Query: 861 LLLLHGA 867
           LLL HGA
Sbjct: 682 LLLAHGA 688



 Score =  109 bits (272), Expect = 2e-23
 Identities = 106/404 (26%), Positives = 187/404 (46%), Gaps = 33/404 (8%)

Query: 469  VAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQ-DN 527
            +AAV G+AS +    +     + +     TP  +          +L ++     + Q ++
Sbjct: 1027 MAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSA-----MLPIYPAIDIDAQTES 1081

Query: 528  NGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQN 587
            N +T L LAC  GHE+ V+ L+        ++  ++KG TPL +AA  G+ GV+E LL N
Sbjct: 1082 NHDTALTLACAGGHEELVQTLLE---RGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138

Query: 588  GASTEIQN-RLKETPLKCALNS---KILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSIS 643
            GA  E Q+ R K+TPL  A +    +++ ++ A   + E R  S   P+        S++
Sbjct: 1139 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL--------SLA 1190

Query: 644  QESSTSSFSSMSASSRQEETKKDYRE--VEKLLRAVADGDLEMVRYLLEWTEEDLEDAED 701
                  +   +  ++  E   +   +  +  L+ A  +G    V+ LL+   +     E 
Sbjct: 1191 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIET 1250

Query: 702  TVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIP 761
              + A    C             + ++ +      V   ++ G +PL  AA  G A++  
Sbjct: 1251 NRNTALTLACFQ--------GRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1302

Query: 762  LLLKHGA--NAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACS 819
            +LL  GA  NA    + +   L +A  +GH++  + L+   A  + ++  GNTPL  A +
Sbjct: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362

Query: 820  GGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLL 863
            GGH ++V LL+Q GA ++A++N+  T L  A  + HV VV  L+
Sbjct: 1363 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406



 Score =  100 bits (250), Expect = 6e-21
 Identities = 104/385 (27%), Positives = 164/385 (42%), Gaps = 41/385 (10%)

Query: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNA-TDYHGATPLHLACQKGYQSVTLLLLHY 518
           ++ GHTPL  A   G   +  LL+  GA +N  ++    + L LAC KG+  +   LL  
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA 423

Query: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQ 578
            A  E + +  +T L  AC  GH +  + L+       ++++  +  ++PL +AA  G+ 
Sbjct: 424 GADQEHKTDEMHTALMEACMDGHVEVARLLLD---SGAQVNMPADSFESPLTLAACGGHV 480

Query: 579 GVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRS 638
            +   L++ GAS E  N    TPL           MEA     E       A +     +
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPL-----------MEAAREGHEEMV----ALLLGQGAN 525

Query: 639 VDSISQESSTSSFSSMSASSRQEETK---KDYREVE-----KLLRAVADGDLEMVRYLLE 690
           +++ ++E+  ++ +        E      K   ++E      L+ A  +G LE+V+YLL 
Sbjct: 526 INAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLA 585

Query: 691 WTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPA-SGLGVNVTSQDGSSPLH 749
                  +   T +  D    +       C      +A V   +G  +   S+ G +PL 
Sbjct: 586 AGA----NVHATTATGDTALTYA------CENGHTDVADVLLQAGADLEHESEGGRTPLM 635

Query: 750 VAALHGRADLIPLLLKHGANAG--ARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKD 807
            AA  G    +  L+  GAN      N D  V L LAC  GH  VV+ LL   A P  + 
Sbjct: 636 KAARAGHVCTVQFLISKGANVNRTTANNDHTV-LSLACAGGHLAVVELLLAHGADPTHRL 694

Query: 808 LSGNTPLIYACSGGHHELVALLLQH 832
             G+T LI A  GGH  +V  LL +
Sbjct: 695 KDGSTMLIEAAKGGHTSVVCYLLDY 719



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 103/387 (26%), Positives = 168/387 (43%), Gaps = 62/387 (16%)

Query: 503 ACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGN 562
           A  +   ++T +     A+A   DN     L  AC+ G  + V+ L+   +E   ++   
Sbjct: 211 ALDEAAAALTRMRAESTANAGQSDNRS---LAEACSEGDVNAVRKLL---IEGRSVNEHT 264

Query: 563 EKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKE-TPLKCALNS---KILSVMEAYH 618
           E+G++ L +A   GY  + + LL   A+ E +    + TPL  A N    KI+ ++ A+ 
Sbjct: 265 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHK 324

Query: 619 LSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVA 678
                                  ++ +SST + +                    L  A A
Sbjct: 325 AD---------------------VNAQSSTGNTA--------------------LTYACA 343

Query: 679 DGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVN 738
            G +++V+ LLE +   +ED  +           PL +       +     +  +G G+N
Sbjct: 344 GGYVDVVKVLLE-SGASIEDHNENGHT-------PLMEAGSAGHVEVARLLLE-NGAGIN 394

Query: 739 VTSQD-GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLL 797
             S +   S L +A   G  +++  LL+ GA+   +  +    L  AC  GH +V + LL
Sbjct: 395 THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL 454

Query: 798 DSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVF 857
           DS A+ N    S  +PL  A  GGH EL ALL++ GAS+   N++G T L EA  E H  
Sbjct: 455 DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEE 514

Query: 858 VVELLLLHGASVQV-LNKRQRTAVDCA 883
           +V LLL  GA++     + Q TA+  A
Sbjct: 515 MVALLLGQGANINAQTEETQETALTLA 541



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 91/360 (25%), Positives = 160/360 (44%), Gaps = 37/360 (10%)

Query: 451  PSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQS 510
            P++      +    T L +A   G   L+  L+ +GA +   D  G TPL LA   G+  
Sbjct: 1071 PAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVG 1130

Query: 511  VTLLLLHYKASAEVQ-DNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPL 569
            V  +LL   A  E Q +   +TPL LAC+ G ++ V+ L+         +  N    TPL
Sbjct: 1131 VVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL---ARGANKEHRNVSDYTPL 1187

Query: 570  HIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFER---RQK 626
             +AA  GY  +I+ LL  GA  EI +R   T  K  ++  +L+ M  +  + +       
Sbjct: 1188 SLAASGGYVNIIKILLNAGA--EINSR---TGSKLGISPLMLAAMNGHTAAVKLLLDMGS 1242

Query: 627  SSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVR 686
               A +++ + +  +++     +   S+    +     +    +  L+ A + G  E+ R
Sbjct: 1243 DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1302

Query: 687  YLLEWTEE----DLEDAEDTVS--AADP---EFCHPLCQCPKCAPAQKRLAKVPASGLGV 737
             LL+   +     +  + DT    AAD    +FC  L                   G  +
Sbjct: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI----------------GRGAHI 1346

Query: 738  NVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLL 797
            +V ++ G++PL +AA  G  D++ LL++ GA+  A +  +  PL  A ++GH +VV+ L+
Sbjct: 1347 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 91/346 (26%), Positives = 151/346 (43%), Gaps = 56/346 (16%)

Query: 566  DTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQ 625
            DT L +A   G++ +++TLL+ GAS E +++   TPL  A  +  + V+E    +    +
Sbjct: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 1143

Query: 626  KSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMV 685
              SE    +P     S  ++       +  A+ ++     DY     L  A + G + ++
Sbjct: 1144 AQSERTKDTPLSLACSGGRQEVVELLLARGAN-KEHRNVSDYTP---LSLAASGGYVNII 1199

Query: 686  RYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGS 745
            + LL                                              G  + S+ GS
Sbjct: 1200 KILLN--------------------------------------------AGAEINSRTGS 1215

Query: 746  ----SPLHVAALHGRADLIPLLLKHGANAGAR-NADQAVPLHLACQQGHFQVVKCLLDSN 800
                SPL +AA++G    + LLL  G++  A+   ++   L LAC QG  +VV  LLD  
Sbjct: 1216 KLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRK 1275

Query: 801  AKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINAS--NNKGNTALHEAVIEKHVFV 858
            A    +  +G TPL+ A SGG+ E+  +LL  GA +NA    +  +TAL  A  + H   
Sbjct: 1276 ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKF 1335

Query: 859  VELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLD 904
             ELL+  GA + V NK+  T +  A  N   ++++Q++    A +D
Sbjct: 1336 CELLIGRGAHIDVRNKKGNTPLWLA-ANGGHLDVVQLLVQAGADVD 1380



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 78/259 (30%), Positives = 120/259 (46%), Gaps = 20/259 (7%)

Query: 641 SISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAE 700
           S + + + ++ + M A S     + D R    L  A ++GD+  VR LL       E  E
Sbjct: 209 SCALDEAAAALTRMRAESTANAGQSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTE 265

Query: 701 DTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQD---GSSPLHVAALHGRA 757
           +  S            C  C+     LA+V  + +  NV  +      +PL  AA  G  
Sbjct: 266 EGESLL----------CLACSAGYYELAQVLLA-MHANVEDRGIKGDITPLMAAANGGHV 314

Query: 758 DLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYA 817
            ++ LLL H A+  A+++     L  AC  G+  VVK LL+S A     + +G+TPL+ A
Sbjct: 315 KIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEA 374

Query: 818 CSGGHHELVALLLQHGASINA-SNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876
            S GH E+  LLL++GA IN  SN    +AL  A  + H+ +V  LL  GA  +      
Sbjct: 375 GSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEM 434

Query: 877 RTAV--DCAEQNSKIMELL 893
            TA+   C + + ++  LL
Sbjct: 435 HTALMEACMDGHVEVARLL 453



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 56/195 (28%), Positives = 93/195 (47%), Gaps = 7/195 (3%)

Query: 706  ADPEFCHPLCQCPKCAPAQKRLAKVPAS-GLGVNVTSQDGSSPLHVAALHGRADLIPLLL 764
            A  E  H       CA   + L +     G  +    + G +PL +AA  G   ++ +LL
Sbjct: 1077 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 1136

Query: 765  KHGANAGARNA-DQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHH 823
             +GA+  A++   +  PL LAC  G  +VV+ LL   A    +++S  TPL  A SGG+ 
Sbjct: 1137 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 1196

Query: 824  ELVALLLQHGASINA--SNNKGNTALHEAVIEKHVFVVELLLLHGASVQV---LNKRQRT 878
             ++ +LL  GA IN+   +  G + L  A +  H   V+LLL  G+ +      N+    
Sbjct: 1197 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1256

Query: 879  AVDCAEQNSKIMELL 893
             + C +  ++++ LL
Sbjct: 1257 TLACFQGRTEVVSLL 1271



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 131/518 (25%), Positives = 205/518 (39%), Gaps = 101/518 (19%)

Query: 464  HTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK---A 520
            HT L +A   G  ++++LL++ GA        G+T L  A + G+ SV   LL Y     
Sbjct: 665  HTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLL 724

Query: 521  SAEVQDNNGNTPLHLACTYGHEDCVKAL--VYYDVE--------SCRLDIGNE---KGDT 567
            SA   D    TP            V+AL  V    E        +  L I N+   K  +
Sbjct: 725  SAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKS 784

Query: 568  PLHIAAR-WGYQGVI-----ETLLQN--GASTEIQNRLKETPLKCALNSKILSVMEAYHL 619
              H+ A     QG I     E++++   G  TE++ R+KE   K A   + L +  A  L
Sbjct: 785  SSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNA-QLQSLELAHADQL 843

Query: 620  SFERRQ---KSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEK---- 672
            + E+ +   K+ E  +Q  Q+ ++ + +        +      Q++ KK Y EV+     
Sbjct: 844  TKEKIEELNKTREEQIQKKQKILEELQKVERELQLKT------QQQLKKQYLEVKAQRIQ 897

Query: 673  -------------LLRAVADGD-LEMVRYL-LEWTEEDLEDAEDTVSAADPEFC--HPLC 715
                         LL  V  G+ L    Y  L+  +  L   E   +AA   F    PL 
Sbjct: 898  LQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFAPIQPLA 957

Query: 716  QCPKCAP----------------------AQKRLAKVPASGLGVNVTS--QDG---SSPL 748
              P+  P                       Q  L +   +GLG  + +  Q G   +SP 
Sbjct: 958  M-PQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPA 1016

Query: 749  H---------VAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL-LD 798
                      +AA+ GRA  +     H   A         P  +        +   + +D
Sbjct: 1017 QTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDID 1076

Query: 799  SNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFV 858
            +  + N      +T L  AC+GGH ELV  LL+ GASI   + KG T L  A    HV V
Sbjct: 1077 AQTESNH-----DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 1131

Query: 859  VELLLLHGASVQVLNKRQR---TAVDCAEQNSKIMELL 893
            VE+LL +GA ++  ++R +    ++ C+    +++ELL
Sbjct: 1132 VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELL 1169



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 71/298 (23%), Positives = 125/298 (41%), Gaps = 42/298 (14%)

Query: 406  ASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDD--CEKLVSGRLNDPSVVTPFSRDDRG 463
            + G Q+ VE LL++  + +        PL          ++   LN  + +   +    G
Sbjct: 1159 SGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1218

Query: 464  HTPLHVAAVCGQASLIDLLVSKGAMVNAT-DYHGATPLHLACQKGYQSVTLLLLHYKASA 522
             +PL +AA+ G  + + LL+  G+ +NA  + +  T L LAC +G   V  LLL  KA+ 
Sbjct: 1219 ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANV 1278

Query: 523  EVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIE 582
            E +   G TPL  A + G+ +  + L+    +     + + + DT L IAA  G+    E
Sbjct: 1279 EHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR-DTALTIAADKGHYKFCE 1337

Query: 583  TLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSI 642
             L+  GA  +++N+   TPL  A N   L V++                           
Sbjct: 1338 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQ--------------------------- 1370

Query: 643  SQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAE 700
                       +   +  +    D R++  L+ A   G +++VRYL++   +   D+E
Sbjct: 1371 -----------LLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSE 1417


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score =  129 bits (323), Expect = 2e-29
 Identities = 153/547 (27%), Positives = 214/547 (39%), Gaps = 69/547 (12%)

Query: 356 EAAIEYIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVER 415
           EA +E    G LS    + + F D         +L ++TSS +  L +  A+  +   E 
Sbjct: 176 EALLEAAGIGKLSTA--DGKAFADP-------EVLRRLTSSVSCALDEAAAALTRMRAES 226

Query: 416 LLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQ 475
             +    D  ++ + C         + L+ GR  +          + G + L +A   G 
Sbjct: 227 TANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVN-------EHTEEGESLLCLACSAGY 279

Query: 476 ASLIDLLVSKGAMVNATDYHG-ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLH 534
             L  +L++  A V      G  TPL  A   G+  +  LLL +KA    Q + GNT L 
Sbjct: 280 YELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALT 339

Query: 535 LACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQ 594
            AC  G+ D VK L+        ++  NE G TPL  A   G+  V   LL+NGA     
Sbjct: 340 YACAGGYVDVVKVLLE---SGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH 396

Query: 595 -NRLKETPLKCALNSKIL----------------------SVMEAY---HLSFERRQKSS 628
            N  KE+ L  A     L                      ++MEA    H+   R    S
Sbjct: 397 SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS 456

Query: 629 EAPVQSPQRSVDSISQESSTSSFSSMSA------SSRQEETKKDYREVEKLLRAVADGDL 682
            A V  P  S +S    ++      ++A      +S +E   + Y     L+ A  +G  
Sbjct: 457 GAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTP---LMEAAREGHE 513

Query: 683 EMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS-GLGVNVTS 741
           EMV  LL          E+T   A    C     C         L K  A   LG     
Sbjct: 514 EMVALLLGQGANINAQTEETQETALTLAC-----CGGFLEVADFLIKAGADIELGC---- 564

Query: 742 QDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNA 801
              S+PL  AA  G  +L+  LL  GAN  A  A     L  AC+ GH  V   LL + A
Sbjct: 565 ---STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGA 621

Query: 802 KPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASN-NKGNTALHEAVIEKHVFVVE 860
               +   G TPL+ A   GH   V  L+  GA++N +  N  +T L  A    H+ VVE
Sbjct: 622 DLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE 681

Query: 861 LLLLHGA 867
           LLL HGA
Sbjct: 682 LLLAHGA 688



 Score =  109 bits (272), Expect = 2e-23
 Identities = 106/407 (26%), Positives = 187/407 (45%), Gaps = 33/407 (8%)

Query: 466  PLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQ 525
            P+   AV G+AS +    +     + +     TP  +          +L ++     + Q
Sbjct: 773  PIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSA-----MLPIYPAIDIDAQ 827

Query: 526  -DNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
             ++N +T L LAC  GHE+ V+ L+        ++  ++KG TPL +AA  G+ GV+E L
Sbjct: 828  TESNHDTALTLACAGGHEELVQTLLE---RGASIEHRDKKGFTPLILAATAGHVGVVEIL 884

Query: 585  LQNGASTEIQN-RLKETPLKCALNS---KILSVMEAYHLSFERRQKSSEAPVQSPQRSVD 640
            L NGA  E Q+ R K+TPL  A +    +++ ++ A   + E R  S   P+        
Sbjct: 885  LDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL-------- 936

Query: 641  SISQESSTSSFSSMSASSRQEETKKDYRE--VEKLLRAVADGDLEMVRYLLEWTEEDLED 698
            S++      +   +  ++  E   +   +  +  L+ A  +G    V+ LL+   +    
Sbjct: 937  SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 996

Query: 699  AEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRAD 758
             E   + A    C             + ++ +      V   ++ G +PL  AA  G A+
Sbjct: 997  IETNRNTALTLACFQ--------GRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1048

Query: 759  LIPLLLKHGA--NAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIY 816
            +  +LL  GA  NA    + +   L +A  +GH++  + L+   A  + ++  GNTPL  
Sbjct: 1049 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWL 1108

Query: 817  ACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLL 863
            A +GGH ++V LL+Q GA ++A++N+  T L  A  + HV VV  L+
Sbjct: 1109 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155



 Score =  103 bits (258), Expect = 6e-22
 Identities = 134/501 (26%), Positives = 208/501 (41%), Gaps = 60/501 (11%)

Query: 463  GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGA-TPLHLACQKGYQSVTLLLLHYKAS 521
            G TPL  AA  G    +  L+SKGA VN T  +   T L LAC  G+ +V  LLL + A 
Sbjct: 630  GRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGAD 689

Query: 522  AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTP----LHIAARWGY 577
               +  +G+T L  A   GH   V  L+ Y          +    TP    L+ A R   
Sbjct: 690  PTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPV 749

Query: 578  QGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVM-----EAYHLSFERRQKSSEAPV 632
            Q +   +          N     P++    S   S M      +   S  + Q  + +P+
Sbjct: 750  QALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPI 809

Query: 633  QSPQR--------SVDSISQESSTSSFSSMSASSRQEETK-----------KDYREVEKL 673
             SP           +D+ ++ +  ++ +   A   +E  +           +D +    L
Sbjct: 810  ISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPL 869

Query: 674  LRAVADGDLEMVRYLLE---WTEEDLEDAEDT-VSAADPEFCHPLCQCPKCAPAQKRLAK 729
            + A   G + +V  LL+     E   E  +DT +S A       + +      A K    
Sbjct: 870  ILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRN 929

Query: 730  V--------PASG-----------LGVNVTSQDGS----SPLHVAALHGRADLIPLLLKH 766
            V         ASG            G  + S+ GS    SPL +AA++G    + LLL  
Sbjct: 930  VSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDM 989

Query: 767  GANAGAR-NADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHEL 825
            G++  A+   ++   L LAC QG  +VV  LLD  A    +  +G TPL+ A SGG+ E+
Sbjct: 990  GSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1049

Query: 826  VALLLQHGASINAS--NNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCA 883
              +LL  GA +NA    +  +TAL  A  + H    ELL+  GA + V NK+  T +  A
Sbjct: 1050 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLA 1109

Query: 884  EQNSKIMELLQVVPSCVASLD 904
              N   ++++Q++    A +D
Sbjct: 1110 -ANGGHLDVVQLLVQAGADVD 1129



 Score = 97.4 bits (241), Expect = 6e-20
 Identities = 117/481 (24%), Positives = 191/481 (39%), Gaps = 78/481 (16%)

Query: 465  TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
            TPL  AA  G   L+  L++ GA V+AT   G T L  AC+ G+  V  +LL   A  E 
Sbjct: 566  TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625

Query: 525  QDNNGNTPL----------------------------------HLACTYGHEDCVKALVY 550
            +   G TPL                                   LAC  GH   V+ L+ 
Sbjct: 626  ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685

Query: 551  YDVESC-RLDIGNEKGDTPLHIAARWGYQGVIETLLQ---NGASTEIQNRLKETPLKCAL 606
            +  +   RL    + G T L  AA+ G+  V+  LL    N  S    +  + TP    L
Sbjct: 686  HGADPTHRL----KDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDL 741

Query: 607  NSKILSVMEAYHLSFERRQK-------SSEAPVQSPQRSVDSISQESSTSSFSSMSASSR 659
            N      ++A  +    ++        ++  P+++   S  + +  ++ +   + S S  
Sbjct: 742  NRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQP 801

Query: 660  QEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPK 719
            Q  T         +L      D++                      A  E  H       
Sbjct: 802  QTPTPSPIISPSAMLPIYPAIDID----------------------AQTESNHDTALTLA 839

Query: 720  CAPAQKRLAKVPAS-GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNA-DQ 777
            CA   + L +     G  +    + G +PL +AA  G   ++ +LL +GA+  A++   +
Sbjct: 840  CAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTK 899

Query: 778  AVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASIN 837
              PL LAC  G  +VV+ LL   A    +++S  TPL  A SGG+  ++ +LL  GA IN
Sbjct: 900  DTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 959

Query: 838  A--SNNKGNTALHEAVIEKHVFVVELLLLHGASVQV---LNKRQRTAVDCAEQNSKIMEL 892
            +   +  G + L  A +  H   V+LLL  G+ +      N+     + C +  ++++ L
Sbjct: 960  SRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSL 1019

Query: 893  L 893
            L
Sbjct: 1020 L 1020



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 103/387 (26%), Positives = 168/387 (43%), Gaps = 62/387 (16%)

Query: 503 ACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGN 562
           A  +   ++T +     A+A   DN     L  AC+ G  + V+ L+   +E   ++   
Sbjct: 211 ALDEAAAALTRMRAESTANAGQSDNRS---LAEACSEGDVNAVRKLL---IEGRSVNEHT 264

Query: 563 EKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKE-TPLKCALNS---KILSVMEAYH 618
           E+G++ L +A   GY  + + LL   A+ E +    + TPL  A N    KI+ ++ A+ 
Sbjct: 265 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHK 324

Query: 619 LSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVA 678
                                  ++ +SST + +                    L  A A
Sbjct: 325 AD---------------------VNAQSSTGNTA--------------------LTYACA 343

Query: 679 DGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVN 738
            G +++V+ LLE +   +ED  +           PL +       +     +  +G G+N
Sbjct: 344 GGYVDVVKVLLE-SGASIEDHNENGHT-------PLMEAGSAGHVEVARLLLE-NGAGIN 394

Query: 739 VTSQD-GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLL 797
             S +   S L +A   G  +++  LL+ GA+   +  +    L  AC  GH +V + LL
Sbjct: 395 THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL 454

Query: 798 DSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVF 857
           DS A+ N    S  +PL  A  GGH EL ALL++ GAS+   N++G T L EA  E H  
Sbjct: 455 DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEE 514

Query: 858 VVELLLLHGASVQV-LNKRQRTAVDCA 883
           +V LLL  GA++     + Q TA+  A
Sbjct: 515 MVALLLGQGANINAQTEETQETALTLA 541



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 91/360 (25%), Positives = 160/360 (44%), Gaps = 37/360 (10%)

Query: 451  PSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQS 510
            P++      +    T L +A   G   L+  L+ +GA +   D  G TPL LA   G+  
Sbjct: 820  PAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVG 879

Query: 511  VTLLLLHYKASAEVQ-DNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPL 569
            V  +LL   A  E Q +   +TPL LAC+ G ++ V+ L+         +  N    TPL
Sbjct: 880  VVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL---ARGANKEHRNVSDYTPL 936

Query: 570  HIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFER---RQK 626
             +AA  GY  +I+ LL  GA  EI +R   T  K  ++  +L+ M  +  + +       
Sbjct: 937  SLAASGGYVNIIKILLNAGA--EINSR---TGSKLGISPLMLAAMNGHTAAVKLLLDMGS 991

Query: 627  SSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVR 686
               A +++ + +  +++     +   S+    +     +    +  L+ A + G  E+ R
Sbjct: 992  DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1051

Query: 687  YLLEWTEE----DLEDAEDTVS--AADP---EFCHPLCQCPKCAPAQKRLAKVPASGLGV 737
             LL+   +     +  + DT    AAD    +FC  L                   G  +
Sbjct: 1052 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI----------------GRGAHI 1095

Query: 738  NVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLL 797
            +V ++ G++PL +AA  G  D++ LL++ GA+  A +  +  PL  A ++GH +VV+ L+
Sbjct: 1096 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 78/259 (30%), Positives = 120/259 (46%), Gaps = 20/259 (7%)

Query: 641 SISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAE 700
           S + + + ++ + M A S     + D R    L  A ++GD+  VR LL       E  E
Sbjct: 209 SCALDEAAAALTRMRAESTANAGQSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTE 265

Query: 701 DTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQD---GSSPLHVAALHGRA 757
           +  S            C  C+     LA+V  + +  NV  +      +PL  AA  G  
Sbjct: 266 EGESLL----------CLACSAGYYELAQVLLA-MHANVEDRGIKGDITPLMAAANGGHV 314

Query: 758 DLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYA 817
            ++ LLL H A+  A+++     L  AC  G+  VVK LL+S A     + +G+TPL+ A
Sbjct: 315 KIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEA 374

Query: 818 CSGGHHELVALLLQHGASINA-SNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876
            S GH E+  LLL++GA IN  SN    +AL  A  + H+ +V  LL  GA  +      
Sbjct: 375 GSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEM 434

Query: 877 RTAV--DCAEQNSKIMELL 893
            TA+   C + + ++  LL
Sbjct: 435 HTALMEACMDGHVEVARLL 453



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 71/298 (23%), Positives = 125/298 (41%), Gaps = 42/298 (14%)

Query: 406  ASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDD--CEKLVSGRLNDPSVVTPFSRDDRG 463
            + G Q+ VE LL++  + +        PL          ++   LN  + +   +    G
Sbjct: 908  SGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 967

Query: 464  HTPLHVAAVCGQASLIDLLVSKGAMVNAT-DYHGATPLHLACQKGYQSVTLLLLHYKASA 522
             +PL +AA+ G  + + LL+  G+ +NA  + +  T L LAC +G   V  LLL  KA+ 
Sbjct: 968  ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANV 1027

Query: 523  EVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIE 582
            E +   G TPL  A + G+ +  + L+    +     + + + DT L IAA  G+    E
Sbjct: 1028 EHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR-DTALTIAADKGHYKFCE 1086

Query: 583  TLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSI 642
             L+  GA  +++N+   TPL  A N   L V++                           
Sbjct: 1087 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQ--------------------------- 1119

Query: 643  SQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAE 700
                       +   +  +    D R++  L+ A   G +++VRYL++   +   D+E
Sbjct: 1120 -----------LLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSE 1166


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  125 bits (314), Expect = 2e-28
 Identities = 123/444 (27%), Positives = 189/444 (42%), Gaps = 58/444 (13%)

Query: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
           TPLH     G    + LL++    V+     G TPL +A Q     +  LLL + A A  
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
            D +G  PLH A   G +   + L+  D  +C +D    +G TPLH+AA+  ++ V   L
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLL--DHGAC-VDAQEREGWTPLHLAAQNNFENVARLL 480

Query: 585 LQNGASTEIQNRLKETPLKCALNSKILSVMEAY--HLSFERRQKSSEAPVQSPQRSVDSI 642
           +   A   +     +TPL  A          AY  H+S  +   S  A + + QR++ + 
Sbjct: 481 VSRQADPNLHEAEGKTPLHVA----------AYFGHVSLVKLLTSQGAELDAQQRNLRT- 529

Query: 643 SQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDT 702
                                         L  AV  G +  +++LL+        +   
Sbjct: 530 -----------------------------PLHLAVERGKVRAIQHLLK--------SGAV 552

Query: 703 VSAADPEFCHPLCQCPKCAPAQKRLAKVPAS-GLGVNVTSQDGSSPLHVAALHGRADLIP 761
             A D     PL      A  +  + K+    G  + + +  G +PLH+AA  G  ++I 
Sbjct: 553 PDALDQSGYGPLHTA--AARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610

Query: 762 LLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGG 821
           LL +  AN GA  A    PLHLA + G   VV  LL   A PN  + SG TPL  A    
Sbjct: 611 LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRS 670

Query: 822 HHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVD 881
               V  LL+H A+++A N  G T  H A ++ +  ++++L+  GA + V +    T + 
Sbjct: 671 TFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQ 730

Query: 882 CAEQNSK--IMELLQVVPSCVASL 903
            A ++ K  IM  L+     VA+L
Sbjct: 731 LALRSRKQGIMSFLEGKEPSVATL 754



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 114/456 (25%), Positives = 179/456 (39%), Gaps = 56/456 (12%)

Query: 382 FLKQRMSLLSQMTSSPTD---CLFKH--------IASGNQKEVERLLSQE-DHDKDTVQK 429
           +LK+ + L  +    P D   C++++        +A G+ ++V  LL+ E D D  T   
Sbjct: 336 YLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASG 395

Query: 430 MCHPLCFCDD-----CEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVS 484
               L    D     C  L++   +   V      D+ G  PLH AA  G      LL+ 
Sbjct: 396 YTPLLIAAQDQQPDLCALLLAHGADANRV------DEDGWAPLHFAAQNGDDGTARLLLD 449

Query: 485 KGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDC 544
            GA V+A +  G TPLHLA Q  +++V  LL+  +A   + +  G TPLH+A  +GH   
Sbjct: 450 HGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSL 509

Query: 545 VKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKC 604
           VK L     E   LD       TPLH+A   G    I+ LL++GA  +  ++    PL  
Sbjct: 510 VKLLTSQGAE---LDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHT 566

Query: 605 AL---NSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQE 661
           A       I  ++  Y  S E        P+                 S ++M A     
Sbjct: 567 AAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN 626

Query: 662 ETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCA 721
            T         L  A   G+  +V  LL+               ADP         P   
Sbjct: 627 WT--------PLHLAARHGEEAVVSALLQ-------------CGADPNAAEQSGWTPLHL 665

Query: 722 PAQK----RLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQ 777
             Q+     +  +      V+  ++ G +P H+AAL G   ++ +L++ GA    ++   
Sbjct: 666 AVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVS 725

Query: 778 AVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTP 813
             PL LA +     ++  L     +P+   L G+ P
Sbjct: 726 CTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 88/287 (30%), Positives = 122/287 (42%), Gaps = 23/287 (8%)

Query: 599 ETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASS 658
           ET +  +L    ++V E+  L+   R+ S +  ++ P    + ISQE   S   +    +
Sbjct: 284 ETDILLSLLQSRVAVPESKALA---RKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRA 340

Query: 659 RQEETKKDY-----------REVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAAD 707
            Q   +K+             +V  L   VA G +E VR LL   E D++    T S   
Sbjct: 341 LQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAH-EVDVDC--QTASGYT 397

Query: 708 PEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHG 767
           P       Q P         A + A G   N   +DG +PLH AA +G      LLL HG
Sbjct: 398 PLLIAAQDQQPDLC------ALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHG 451

Query: 768 ANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVA 827
           A   A+  +   PLHLA Q     V + L+   A PN  +  G TPL  A   GH  LV 
Sbjct: 452 ACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVK 511

Query: 828 LLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNK 874
           LL   GA ++A      T LH AV    V  ++ LL  GA    L++
Sbjct: 512 LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQ 558



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 96/383 (25%), Positives = 143/383 (37%), Gaps = 35/383 (9%)

Query: 521 SAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGV 580
           S E+ D++    L  A         K LV  D E C      E   TPLH     G    
Sbjct: 325 SQELMDSDSGNYLKRALQLSDR---KNLVPRDEELCIY----ENKVTPLHFLVAQGSVEQ 377

Query: 581 IETLLQNGASTEIQNRLKETPLKCALNSK---ILSVMEAYHLSFERRQKSSEAPVQSPQR 637
           +  LL +    + Q     TPL  A   +   + +++ A+     R  +   AP+    +
Sbjct: 378 VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQ 437

Query: 638 SVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEED-- 695
           + D  +        + + A  R+  T          L   A  + E V  LL   + D  
Sbjct: 438 NGDDGTARLLLDHGACVDAQEREGWTP---------LHLAAQNNFENVARLLVSRQADPN 488

Query: 696 LEDAED-TVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS-GLGVNVTSQDGSSPLHVAAL 753
           L +AE  T       F H              L K+  S G  ++   ++  +PLH+A  
Sbjct: 489 LHEAEGKTPLHVAAYFGHV------------SLVKLLTSQGAELDAQQRNLRTPLHLAVE 536

Query: 754 HGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTP 813
            G+   I  LLK GA   A +     PLH A  +G + + K LL   A        G TP
Sbjct: 537 RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTP 596

Query: 814 LIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLN 873
           L  A   GH E++ LL +  A++ A      T LH A       VV  LL  GA      
Sbjct: 597 LHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAE 656

Query: 874 KRQRTAVDCAEQNSKIMELLQVV 896
           +   T +  A Q S  + ++ ++
Sbjct: 657 QSGWTPLHLAVQRSTFLSVINLL 679


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  124 bits (311), Expect = 5e-28
 Identities = 111/398 (27%), Positives = 179/398 (44%), Gaps = 21/398 (5%)

Query: 474 GQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGN-TP 532
           G  + +  L+ +G  VN     G + L LAC  GY  +  +LL   A+ E + N G+ TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 533 LHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTE 592
           L  A + G+ D VK L+ +D +   ++  +  G+T L  A   G+  +++ LL  GA+ E
Sbjct: 276 LMAASSGGYLDIVKLLLLHDAD---VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332

Query: 593 IQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFS 652
             N    TPL  A ++     +E   +  +     +    +  + ++     +       
Sbjct: 333 DHNENGHTPLMEAASA---GHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 389

Query: 653 SMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCH 712
            +  +   +E K D      L+ A  DG +E+ R LL        D+   V+     F  
Sbjct: 390 FLLEAGADQEHKTDEMHTA-LMEACMDGHVEVARLLL--------DSGAQVNMPADSFES 440

Query: 713 PLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGA 772
           PL     C    +  A +   G  +   + +G +PL  AA  G  +++ LLL  GAN  A
Sbjct: 441 PLTLAA-CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499

Query: 773 RNAD-QAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQ 831
           +  + Q   L LAC  G  +V   L+ + A     +L  +TPL+ A   GH ELV  LL 
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLA 556

Query: 832 HGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASV 869
            GA+++A+   G+TAL  A    H  V ++LL  GA +
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 97/352 (27%), Positives = 154/352 (43%), Gaps = 55/352 (15%)

Query: 536 ACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQ- 594
           AC+ G  + V+ L+    E   ++   E+G++ L +A   GY  + + LL   A+ E + 
Sbjct: 212 ACSDGDVNAVRKLLD---EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 595 NRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSM 654
           N+   TPL  A +   L +++   L                   V+S S   +T+     
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLH---------------DADVNSQSATGNTA----- 308

Query: 655 SASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPL 714
                             L  A A G +++V+ LL     ++ED  +           PL
Sbjct: 309 ------------------LTYACAGGFVDIVKVLLN-EGANIEDHNENGHT-------PL 342

Query: 715 CQCPKCAPAQKRLAKVPAS-GLGVNVTSQD-GSSPLHVAALHGRADLIPLLLKHGANAGA 772
            +       +  +A+V    G G+N  S +   S L +A   G  D++  LL+ GA+   
Sbjct: 343 MEAASAGHVE--VARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400

Query: 773 RNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQH 832
           +  +    L  AC  GH +V + LLDS A+ N    S  +PL  A  GGH EL ALL++ 
Sbjct: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460

Query: 833 GASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQV-LNKRQRTAVDCA 883
           GA++   N++G T L EA  E H  +V LLL  GA++     + Q TA+  A
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 76/259 (29%), Positives = 119/259 (45%), Gaps = 20/259 (7%)

Query: 641 SISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAE 700
           S + + + ++ + M A +     + D R    L  A +DGD+  VR LL+      E  E
Sbjct: 180 SCALDEAAAALTRMKAENSHNAGQVDTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTE 236

Query: 701 DTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGS---SPLHVAALHGRA 757
           +  S            C  C+     LA+V  + +  NV  +      +PL  A+  G  
Sbjct: 237 EGESLL----------CLACSAGYYELAQVLLA-MHANVEDRGNKGDITPLMAASSGGYL 285

Query: 758 DLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYA 817
           D++ LLL H A+  +++A     L  AC  G   +VK LL+  A     + +G+TPL+ A
Sbjct: 286 DIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345

Query: 818 CSGGHHELVALLLQHGASINA-SNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876
            S GH E+  +LL HGA IN  SN    +AL  A  + H+ +V  LL  GA  +      
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM 405

Query: 877 RTAV--DCAEQNSKIMELL 893
            TA+   C + + ++  LL
Sbjct: 406 HTALMEACMDGHVEVARLL 424



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 78/255 (30%), Positives = 116/255 (45%), Gaps = 21/255 (8%)

Query: 636 QRSVDSISQESSTSSFSSMSASSRQEET--KKDYREVEKLLRAV-------ADG----DL 682
           Q  +D+   ++++  F S +A      T   +    +E LL A        ADG    D 
Sbjct: 110 QEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADP 169

Query: 683 EMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQ-------KRLAKVPASGL 735
           E++R L       L++A   ++    E  H   Q    + A+         + K+   G 
Sbjct: 170 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 229

Query: 736 GVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGAR-NADQAVPLHLACQQGHFQVVK 794
            VN  +++G S L +A   G  +L  +LL   AN   R N     PL  A   G+  +VK
Sbjct: 230 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 289

Query: 795 CLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEK 854
            LL  +A  N +  +GNT L YAC+GG  ++V +LL  GA+I   N  G+T L EA    
Sbjct: 290 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349

Query: 855 HVFVVELLLLHGASV 869
           HV V  +LL HGA +
Sbjct: 350 HVEVARVLLDHGAGI 364



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 49/140 (35%), Positives = 71/140 (50%), Gaps = 7/140 (5%)

Query: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNA-TDYHGATPLHLACQKGYQSVTLLLLHY 518
           +D G+TPL  AA  G   ++ LL+++GA +NA T+    T L LAC  G+  V   L+  
Sbjct: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLI-- 525

Query: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQ 578
           KA A+++    +TPL  A   GH + VK L+        +      GDT L  A   G+ 
Sbjct: 526 KAGADIE-LGCSTPLMEASQEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHT 581

Query: 579 GVIETLLQNGASTEIQNRLK 598
            V + LLQ GA  + Q  +K
Sbjct: 582 DVADVLLQAGADLDKQEDMK 601


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  124 bits (311), Expect = 5e-28
 Identities = 111/398 (27%), Positives = 179/398 (44%), Gaps = 21/398 (5%)

Query: 474 GQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGN-TP 532
           G  + +  L+ +G  VN     G + L LAC  GY  +  +LL   A+ E + N G+ TP
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264

Query: 533 LHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTE 592
           L  A + G+ D VK L+ +D +   ++  +  G+T L  A   G+  +++ LL  GA+ E
Sbjct: 265 LMAASSGGYLDIVKLLLLHDAD---VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 321

Query: 593 IQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFS 652
             N    TPL  A ++     +E   +  +     +    +  + ++     +       
Sbjct: 322 DHNENGHTPLMEAASA---GHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 378

Query: 653 SMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCH 712
            +  +   +E K D      L+ A  DG +E+ R LL        D+   V+     F  
Sbjct: 379 FLLEAGADQEHKTDEMHTA-LMEACMDGHVEVARLLL--------DSGAQVNMPADSFES 429

Query: 713 PLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGA 772
           PL     C    +  A +   G  +   + +G +PL  AA  G  +++ LLL  GAN  A
Sbjct: 430 PLTLAA-CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488

Query: 773 RNAD-QAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQ 831
           +  + Q   L LAC  G  +V   L+ + A     +L  +TPL+ A   GH ELV  LL 
Sbjct: 489 QTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLA 545

Query: 832 HGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASV 869
            GA+++A+   G+TAL  A    H  V ++LL  GA +
Sbjct: 546 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 76/244 (31%), Positives = 114/244 (46%), Gaps = 10/244 (4%)

Query: 636 QRSVDSISQESSTSSFSSMSASSRQEET--KKDYREVEKLLRAVADGDLEMVRYLLEWTE 693
           Q  +D+   ++++  F S +A      T   +    +E LL A A  D E++R L     
Sbjct: 110 QEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVS 169

Query: 694 EDLEDAEDTVSAADPEFCHPLCQCPKCAPAQ-------KRLAKVPASGLGVNVTSQDGSS 746
             L++A   ++    E  H   Q    + A+         + K+   G  VN  +++G S
Sbjct: 170 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 229

Query: 747 PLHVAALHGRADLIPLLLKHGANAGAR-NADQAVPLHLACQQGHFQVVKCLLDSNAKPNK 805
            L +A   G  +L  +LL   AN   R N     PL  A   G+  +VK LL  +A  N 
Sbjct: 230 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 289

Query: 806 KDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLH 865
           +  +GNT L YAC+GG  ++V +LL  GA+I   N  G+T L EA    HV V  +LL H
Sbjct: 290 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 349

Query: 866 GASV 869
           GA +
Sbjct: 350 GAGI 353



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 97/352 (27%), Positives = 154/352 (43%), Gaps = 55/352 (15%)

Query: 536 ACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQ- 594
           AC+ G  + V+ L+    E   ++   E+G++ L +A   GY  + + LL   A+ E + 
Sbjct: 201 ACSDGDVNAVRKLLD---EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257

Query: 595 NRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSM 654
           N+   TPL  A +   L +++   L                   V+S S   +T+     
Sbjct: 258 NKGDITPLMAASSGGYLDIVKLLLLH---------------DADVNSQSATGNTA----- 297

Query: 655 SASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPL 714
                             L  A A G +++V+ LL     ++ED  +           PL
Sbjct: 298 ------------------LTYACAGGFVDIVKVLLN-EGANIEDHNENGHT-------PL 331

Query: 715 CQCPKCAPAQKRLAKVPAS-GLGVNVTSQD-GSSPLHVAALHGRADLIPLLLKHGANAGA 772
            +       +  +A+V    G G+N  S +   S L +A   G  D++  LL+ GA+   
Sbjct: 332 MEAASAGHVE--VARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 389

Query: 773 RNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQH 832
           +  +    L  AC  GH +V + LLDS A+ N    S  +PL  A  GGH EL ALL++ 
Sbjct: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449

Query: 833 GASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQV-LNKRQRTAVDCA 883
           GA++   N++G T L EA  E H  +V LLL  GA++     + Q TA+  A
Sbjct: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 76/259 (29%), Positives = 119/259 (45%), Gaps = 20/259 (7%)

Query: 641 SISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAE 700
           S + + + ++ + M A +     + D R    L  A +DGD+  VR LL+      E  E
Sbjct: 169 SCALDEAAAALTRMKAENSHNAGQVDTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTE 225

Query: 701 DTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGS---SPLHVAALHGRA 757
           +  S            C  C+     LA+V  + +  NV  +      +PL  A+  G  
Sbjct: 226 EGESLL----------CLACSAGYYELAQVLLA-MHANVEDRGNKGDITPLMAASSGGYL 274

Query: 758 DLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYA 817
           D++ LLL H A+  +++A     L  AC  G   +VK LL+  A     + +G+TPL+ A
Sbjct: 275 DIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 334

Query: 818 CSGGHHELVALLLQHGASINA-SNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876
            S GH E+  +LL HGA IN  SN    +AL  A  + H+ +V  LL  GA  +      
Sbjct: 335 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM 394

Query: 877 RTAV--DCAEQNSKIMELL 893
            TA+   C + + ++  LL
Sbjct: 395 HTALMEACMDGHVEVARLL 413



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 89/352 (25%), Positives = 133/352 (37%), Gaps = 55/352 (15%)

Query: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLH 517
           S+   G+T L  A   G   ++ +L+++GA +   + +G TPL  A   G+  V  +LL 
Sbjct: 289 SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLD 348

Query: 518 YKASAEVQDNN-GNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWG 576
           + A      N    + L LAC  GH D V+ L+    +    +   ++  T L  A   G
Sbjct: 349 HGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ---EHKTDEMHTALMEACMDG 405

Query: 577 YQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQ 636
           +  V   LL +GA   +     E+PL  A        +E   L  ER             
Sbjct: 406 HVEVARLLLDSGAQVNMPADSFESPLTLAACG---GHVELAALLIER------------G 450

Query: 637 RSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDL 696
            +++ ++ E  T                        L+ A  +G  EMV  LL       
Sbjct: 451 ANLEEVNDEGYT-----------------------PLMEAAREGHEEMVALLLAQGANIN 487

Query: 697 EDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS-GLGVNVTSQDGSSPLHVAALHG 755
              E+T   A    C     C   +     L K  A   LG        S+PL  A+  G
Sbjct: 488 AQTEETQETALTLAC-----CGGFSEVADFLIKAGADIELGC-------STPLMEASQEG 535

Query: 756 RADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKD 807
             +L+  LL  GAN  A  A     L  AC+ GH  V   LL + A  +K++
Sbjct: 536 HLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 587



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 49/140 (35%), Positives = 71/140 (50%), Gaps = 7/140 (5%)

Query: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNA-TDYHGATPLHLACQKGYQSVTLLLLHY 518
           +D G+TPL  AA  G   ++ LL+++GA +NA T+    T L LAC  G+  V   L+  
Sbjct: 457 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLI-- 514

Query: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQ 578
           KA A+++    +TPL  A   GH + VK L+        +      GDT L  A   G+ 
Sbjct: 515 KAGADIE-LGCSTPLMEASQEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHT 570

Query: 579 GVIETLLQNGASTEIQNRLK 598
            V + LLQ GA  + Q  +K
Sbjct: 571 DVADVLLQAGADLDKQEDMK 590


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  117 bits (294), Expect = 4e-26
 Identities = 111/420 (26%), Positives = 179/420 (42%), Gaps = 25/420 (5%)

Query: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSV--TLLL 515
           ++D    T LH +A       + LL+   + +   D  G  PLH A      S   T+  
Sbjct: 144 TQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRC 203

Query: 516 LHYKASAEV----QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHI 571
           +   A  E     QD  G TPLH A   G+   V  L  Y  ESC +   +    TPLH 
Sbjct: 204 ILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY--ESCNITSYDNLFRTPLHW 261

Query: 572 AARWGYQGVIETLLQNGASTEIQNRLK-ETPLKCALNSKILSVMEAYHLSFERRQKSSEA 630
           AA  G+  ++  LL+   S  I +  +  TPL  A  S     ++ +    +      ++
Sbjct: 262 AALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVF---LKHPSVKDDS 318

Query: 631 PVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLE 690
            ++     + +  + S     + +S  S  +    D      L  A   G +  V+ LLE
Sbjct: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378

Query: 691 WTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAK-VPASGLGVNVTSQDGSSPLH 749
              +        V A D     PL +   C    K + + +   G  V++  QDG S LH
Sbjct: 379 NNAQ--------VDATDVMKHTPLFRA--CEMGHKDVIQTLIKGGARVDLVDQDGHSLLH 428

Query: 750 VAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLS 809
            AAL G AD+  +L+++  N   ++     PL  A   G+   +  L+++NA PN +D  
Sbjct: 429 WAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKE 488

Query: 810 GNTPLIYACSGGHHELVALLLQHGASIN--ASNNKGNTALHEAVIEKHVFVVELLLLHGA 867
           G T L ++C+ G+ + + LLL   A  N   +N +  T L  A++ +   V++ +L HGA
Sbjct: 489 GRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score =  117 bits (293), Expect = 6e-26
 Identities = 158/673 (23%), Positives = 265/673 (39%), Gaps = 99/673 (14%)

Query: 460  DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
            D  G TPL    +  +    D L+  GA VN TD+   T LHLA QKG      LLL  +
Sbjct: 45   DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104

Query: 520  ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQG 579
            A+   +D    TPLHL   +    C+  L+ +      +D  ++   T LH +A +    
Sbjct: 105  ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG-EVDTQDKNKQTALHWSAYYNNPE 163

Query: 580  VIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQ--R 637
             ++ L+++ ++  I +   + PL  A N K  S +       +     S    Q  +   
Sbjct: 164  HVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRT 223

Query: 638  SVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEE--- 694
             +     + + +    +++      T  D      L  A   G  ++V  LLE  +    
Sbjct: 224  PLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTI 283

Query: 695  --DLEDAEDTVSAADPEFC--------HPLCQCPKCAPAQKRLAKVPASGLG-------- 736
              D + A     AA   F         HP  +    +  + R + + A+G G        
Sbjct: 284  PSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTM 341

Query: 737  --------VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQG 788
                    +N+  + G + LH AAL G    + LLL++ A   A +  +  PL  AC+ G
Sbjct: 342  LSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMG 401

Query: 789  HFQVVKCLLDSNAK---------------------------------PNKKDLSGNTPLI 815
            H  V++ L+   A+                                 PN +D +G TPL 
Sbjct: 402  HKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQ 461

Query: 816  YACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVL--N 873
             A  GG+   +A+L+++ A  N  + +G TALH +    ++  ++LLL   A    +  N
Sbjct: 462  CAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENN 521

Query: 874  KRQRTAVDCA---EQNSKIMELLQVVPSCVASLDDVAETD-RKEYVTVKIRKKWNSKLYD 929
            + + T +D A   E++  I  +L+     +A++ D+A    +  Y   K+RK +  +   
Sbjct: 522  EERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNL 581

Query: 930  LPDEPFTRQFYFV---------HSAGQFKGKTSREIMARDRSVPNLTEGSLHEPGRQSVT 980
            L      R+               A Q KG+ S +   R +++P L       P  Q V 
Sbjct: 582  LMKHEQLRKDAAAKKREEENKRKEAEQQKGRRSPD-SCRPQALPCL-------PSTQDVP 633

Query: 981  LRQNNLPAQ---SGSHAAEKGNSDWPERPGLTQTGPGHRRMLRRHTVEDAVVSQGPEAAG 1037
             RQ+  P++   +G+ A      D    PG +  G   +    +H   D    QG  +  
Sbjct: 634  SRQSRAPSKQPPAGNVAQGPEPRDSRGSPGGSLGGALQK---EQHVSSDL---QGTNSRR 687

Query: 1038 PLSTPQEVSASRS 1050
            P  T +E S  +S
Sbjct: 688  PNETAREHSKGQS 700



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 100/404 (24%), Positives = 160/404 (39%), Gaps = 48/404 (11%)

Query: 497 ATPLHLACQKGYQ-SVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVES 555
           A+ +H A   G + ++  L++   A  + +D  G TPL         DC  AL+    + 
Sbjct: 15  ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADV 74

Query: 556 CRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVME 615
            + D       T LH+AA+ G    ++ LL   A+   ++  + TPL             
Sbjct: 75  NKTDHSQR---TALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPL------------- 118

Query: 616 AYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLR 675
             HL+   R     A +       +  +Q+ +  +    SA     E       V+ L++
Sbjct: 119 --HLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPE------HVKLLIK 170

Query: 676 AVADGDLEMV--RYLLEWTEE--------------DLEDAEDTVSAADPEFCHPLCQCPK 719
             ++  +  V  +  L W                 D    E  ++  D E   PL     
Sbjct: 171 HDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFA-- 228

Query: 720 CAPAQKRLAKVPASGLGVNVTSQDG--SSPLHVAALHGRADLIPLLLKHGANAGARNADQ 777
            A     +  V  S    N+TS D    +PLH AAL G A ++ LLL+   +    +  Q
Sbjct: 229 VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ 288

Query: 778 -AVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELV--ALLLQHGA 834
            A PLH A Q    + VK  L   +  +  DL G T  ++A   G  +++   L L+   
Sbjct: 289 GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348

Query: 835 SINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRT 878
            IN ++  G TALH A +  HV  V+LLL + A V   +  + T
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHT 392



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 59/232 (25%), Positives = 90/232 (38%), Gaps = 41/232 (17%)

Query: 438 DDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGA 497
           D C+ L+  ++N      P  +D  G TPL  AA  G  + + +L+   A  N  D  G 
Sbjct: 437 DVCQILIENKIN------PNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490

Query: 498 TPLHLACQKGYQSVTLLLLHYKASAEVQDNNGN--TPLHLACTYGHEDCVKALVYYDVES 555
           T LH +C  GY     LLL + A     +NN    TPL  A      + ++ ++ +    
Sbjct: 491 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA-- 548

Query: 556 CRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVME 615
                        L IAA           +Q+ A+ +IQ   K   ++ A   +   +M+
Sbjct: 549 -------------LSIAA-----------IQDIAAFKIQAVYKGYKVRKAFRDRKNLLMK 584

Query: 616 AYHL-------SFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQ 660
              L         E   K  EA  Q  +RS DS   ++     S+    SRQ
Sbjct: 585 HEQLRKDAAAKKREEENKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQ 636



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 63/245 (25%), Positives = 107/245 (43%), Gaps = 19/245 (7%)

Query: 676 AVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGL 735
           A  +GD   ++ L+      L+D ED        +C  L     CA A  +      +G 
Sbjct: 21  AAVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYC-VLADRLDCADALLK------AGA 72

Query: 736 GVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKC 795
            VN T     + LH+AA  G    + LLL   AN   ++ ++  PLHL  +    + +  
Sbjct: 73  DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132

Query: 796 LLDSNA--KPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIE 853
           LL   A  + + +D +  T L ++    + E V LL++H ++I   + +G   LH A   
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192

Query: 854 KH---VFVVELLLLHGASVQVLNKRQ---RTAVD--CAEQNSKIMELLQVVPSC-VASLD 904
           K    V  V  +L    +  +LN +    RT +    A+ N  ++++L    SC + S D
Sbjct: 193 KDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYD 252

Query: 905 DVAET 909
           ++  T
Sbjct: 253 NLFRT 257



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 31/100 (31%), Positives = 50/100 (50%), Gaps = 4/100 (4%)

Query: 770 AGARNADQAVPLHLACQQGHFQVVKCLLDSN-AKPNKKDLSGNTPLIYACSGGHHELVAL 828
           AG+  A Q   +H A   G    ++ L+  N A  +K+D  G TPL+Y       +    
Sbjct: 10  AGSSLASQ---VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADA 66

Query: 829 LLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGAS 868
           LL+ GA +N +++   TALH A  + +   ++LLL   A+
Sbjct: 67  LLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN 106


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  117 bits (294), Expect = 4e-26
 Identities = 111/420 (26%), Positives = 179/420 (42%), Gaps = 25/420 (5%)

Query: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSV--TLLL 515
           ++D    T LH +A       + LL+   + +   D  G  PLH A      S   T+  
Sbjct: 144 TQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRC 203

Query: 516 LHYKASAEV----QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHI 571
           +   A  E     QD  G TPLH A   G+   V  L  Y  ESC +   +    TPLH 
Sbjct: 204 ILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY--ESCNITSYDNLFRTPLHW 261

Query: 572 AARWGYQGVIETLLQNGASTEIQNRLK-ETPLKCALNSKILSVMEAYHLSFERRQKSSEA 630
           AA  G+  ++  LL+   S  I +  +  TPL  A  S     ++ +    +      ++
Sbjct: 262 AALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVF---LKHPSVKDDS 318

Query: 631 PVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLE 690
            ++     + +  + S     + +S  S  +    D      L  A   G +  V+ LLE
Sbjct: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378

Query: 691 WTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAK-VPASGLGVNVTSQDGSSPLH 749
              +        V A D     PL +   C    K + + +   G  V++  QDG S LH
Sbjct: 379 NNAQ--------VDATDVMKHTPLFRA--CEMGHKDVIQTLIKGGARVDLVDQDGHSLLH 428

Query: 750 VAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLS 809
            AAL G AD+  +L+++  N   ++     PL  A   G+   +  L+++NA PN +D  
Sbjct: 429 WAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKE 488

Query: 810 GNTPLIYACSGGHHELVALLLQHGASIN--ASNNKGNTALHEAVIEKHVFVVELLLLHGA 867
           G T L ++C+ G+ + + LLL   A  N   +N +  T L  A++ +   V++ +L HGA
Sbjct: 489 GRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score =  117 bits (293), Expect = 6e-26
 Identities = 158/673 (23%), Positives = 265/673 (39%), Gaps = 99/673 (14%)

Query: 460  DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
            D  G TPL    +  +    D L+  GA VN TD+   T LHLA QKG      LLL  +
Sbjct: 45   DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104

Query: 520  ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQG 579
            A+   +D    TPLHL   +    C+  L+ +      +D  ++   T LH +A +    
Sbjct: 105  ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG-EVDTQDKNKQTALHWSAYYNNPE 163

Query: 580  VIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQ--R 637
             ++ L+++ ++  I +   + PL  A N K  S +       +     S    Q  +   
Sbjct: 164  HVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRT 223

Query: 638  SVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEE--- 694
             +     + + +    +++      T  D      L  A   G  ++V  LLE  +    
Sbjct: 224  PLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTI 283

Query: 695  --DLEDAEDTVSAADPEFC--------HPLCQCPKCAPAQKRLAKVPASGLG-------- 736
              D + A     AA   F         HP  +    +  + R + + A+G G        
Sbjct: 284  PSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTM 341

Query: 737  --------VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQG 788
                    +N+  + G + LH AAL G    + LLL++ A   A +  +  PL  AC+ G
Sbjct: 342  LSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMG 401

Query: 789  HFQVVKCLLDSNAK---------------------------------PNKKDLSGNTPLI 815
            H  V++ L+   A+                                 PN +D +G TPL 
Sbjct: 402  HKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQ 461

Query: 816  YACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVL--N 873
             A  GG+   +A+L+++ A  N  + +G TALH +    ++  ++LLL   A    +  N
Sbjct: 462  CAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENN 521

Query: 874  KRQRTAVDCA---EQNSKIMELLQVVPSCVASLDDVAETD-RKEYVTVKIRKKWNSKLYD 929
            + + T +D A   E++  I  +L+     +A++ D+A    +  Y   K+RK +  +   
Sbjct: 522  EERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNL 581

Query: 930  LPDEPFTRQFYFV---------HSAGQFKGKTSREIMARDRSVPNLTEGSLHEPGRQSVT 980
            L      R+               A Q KG+ S +   R +++P L       P  Q V 
Sbjct: 582  LMKHEQLRKDAAAKKREEENKRKEAEQQKGRRSPD-SCRPQALPCL-------PSTQDVP 633

Query: 981  LRQNNLPAQ---SGSHAAEKGNSDWPERPGLTQTGPGHRRMLRRHTVEDAVVSQGPEAAG 1037
             RQ+  P++   +G+ A      D    PG +  G   +    +H   D    QG  +  
Sbjct: 634  SRQSRAPSKQPPAGNVAQGPEPRDSRGSPGGSLGGALQK---EQHVSSDL---QGTNSRR 687

Query: 1038 PLSTPQEVSASRS 1050
            P  T +E S  +S
Sbjct: 688  PNETAREHSKGQS 700



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 100/404 (24%), Positives = 160/404 (39%), Gaps = 48/404 (11%)

Query: 497 ATPLHLACQKGYQ-SVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVES 555
           A+ +H A   G + ++  L++   A  + +D  G TPL         DC  AL+    + 
Sbjct: 15  ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADV 74

Query: 556 CRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVME 615
            + D       T LH+AA+ G    ++ LL   A+   ++  + TPL             
Sbjct: 75  NKTDHSQR---TALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPL------------- 118

Query: 616 AYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLR 675
             HL+   R     A +       +  +Q+ +  +    SA     E       V+ L++
Sbjct: 119 --HLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPE------HVKLLIK 170

Query: 676 AVADGDLEMV--RYLLEWTEE--------------DLEDAEDTVSAADPEFCHPLCQCPK 719
             ++  +  V  +  L W                 D    E  ++  D E   PL     
Sbjct: 171 HDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFA-- 228

Query: 720 CAPAQKRLAKVPASGLGVNVTSQDG--SSPLHVAALHGRADLIPLLLKHGANAGARNADQ 777
            A     +  V  S    N+TS D    +PLH AAL G A ++ LLL+   +    +  Q
Sbjct: 229 VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ 288

Query: 778 -AVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELV--ALLLQHGA 834
            A PLH A Q    + VK  L   +  +  DL G T  ++A   G  +++   L L+   
Sbjct: 289 GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348

Query: 835 SINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRT 878
            IN ++  G TALH A +  HV  V+LLL + A V   +  + T
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHT 392



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 59/232 (25%), Positives = 90/232 (38%), Gaps = 41/232 (17%)

Query: 438 DDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGA 497
           D C+ L+  ++N      P  +D  G TPL  AA  G  + + +L+   A  N  D  G 
Sbjct: 437 DVCQILIENKIN------PNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490

Query: 498 TPLHLACQKGYQSVTLLLLHYKASAEVQDNNGN--TPLHLACTYGHEDCVKALVYYDVES 555
           T LH +C  GY     LLL + A     +NN    TPL  A      + ++ ++ +    
Sbjct: 491 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA-- 548

Query: 556 CRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVME 615
                        L IAA           +Q+ A+ +IQ   K   ++ A   +   +M+
Sbjct: 549 -------------LSIAA-----------IQDIAAFKIQAVYKGYKVRKAFRDRKNLLMK 584

Query: 616 AYHL-------SFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQ 660
              L         E   K  EA  Q  +RS DS   ++     S+    SRQ
Sbjct: 585 HEQLRKDAAAKKREEENKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQ 636



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 63/245 (25%), Positives = 107/245 (43%), Gaps = 19/245 (7%)

Query: 676 AVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGL 735
           A  +GD   ++ L+      L+D ED        +C  L     CA A  +      +G 
Sbjct: 21  AAVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYC-VLADRLDCADALLK------AGA 72

Query: 736 GVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKC 795
            VN T     + LH+AA  G    + LLL   AN   ++ ++  PLHL  +    + +  
Sbjct: 73  DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132

Query: 796 LLDSNA--KPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIE 853
           LL   A  + + +D +  T L ++    + E V LL++H ++I   + +G   LH A   
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192

Query: 854 KH---VFVVELLLLHGASVQVLNKRQ---RTAVD--CAEQNSKIMELLQVVPSC-VASLD 904
           K    V  V  +L    +  +LN +    RT +    A+ N  ++++L    SC + S D
Sbjct: 193 KDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYD 252

Query: 905 DVAET 909
           ++  T
Sbjct: 253 NLFRT 257



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 31/100 (31%), Positives = 50/100 (50%), Gaps = 4/100 (4%)

Query: 770 AGARNADQAVPLHLACQQGHFQVVKCLLDSN-AKPNKKDLSGNTPLIYACSGGHHELVAL 828
           AG+  A Q   +H A   G    ++ L+  N A  +K+D  G TPL+Y       +    
Sbjct: 10  AGSSLASQ---VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADA 66

Query: 829 LLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGAS 868
           LL+ GA +N +++   TALH A  + +   ++LLL   A+
Sbjct: 67  LLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN 106


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  106 bits (264), Expect = 1e-22
 Identities = 98/386 (25%), Positives = 155/386 (40%), Gaps = 58/386 (15%)

Query: 461 DRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKA 520
           D G + LH+A   GQ      L+   A  N ++  G+TPLH+A ++  + V  LLL  K 
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKI 495

Query: 521 SAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGV 580
           S   +D +  T LH A   G E   + L+  +     +D    +G TP+H+A + G + +
Sbjct: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF---EGRTPMHVACQHGQENI 552

Query: 581 IETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVD 640
           +  LL+ G    +Q +    PL  A     L +++                 + P  SV+
Sbjct: 553 VRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL--------------AKQPGVSVN 598

Query: 641 SISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAE 700
           + + +  T                        L  A   G   + R L++          
Sbjct: 599 AQTLDGRTP-----------------------LHLAAQRGHYRVARILIDL--------- 626

Query: 701 DTVSAADPEFCHPLCQCPKCAPAQKRLAKVPA----SGLGVNVTSQDGSSPLHVAALHGR 756
                +D   C  L Q P    A+             G G    + DG + LH+AA +G 
Sbjct: 627 ----CSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGH 682

Query: 757 ADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIY 816
              + LL++  A+  AR       LHLA   GH +VV+ L+ ++   +  D  G + L  
Sbjct: 683 LATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVI-DLFDEQGLSALHL 741

Query: 817 ACSGGHHELVALLLQHGASINASNNK 842
           A  G H + V  LL+HGA IN  + K
Sbjct: 742 AAQGRHAQTVETLLRHGAHINLQSLK 767



 Score =  105 bits (261), Expect = 3e-22
 Identities = 95/350 (27%), Positives = 148/350 (42%), Gaps = 50/350 (14%)

Query: 558 LDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAY 617
           +D+  + G + LH+A   G +   + LL N A+  + NR   TPL               
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL--------------- 475

Query: 618 HLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAV 677
           H++ ERR +     + + + SV++  ++  T+                       L  A 
Sbjct: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTA-----------------------LHFAA 512

Query: 678 ADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS-GLG 736
            +GD    R LLE           +V+  D E   P+     C   Q+ + ++    G+ 
Sbjct: 513 QNGDESSTRLLLE--------KNASVNEVDFEGRTPMHVA--CQHGQENIVRILLRRGVD 562

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKH-GANAGARNADQAVPLHLACQQGHFQVVKC 795
           V++  +D   PLH AA  G   ++ LL K  G +  A+  D   PLHLA Q+GH++V + 
Sbjct: 563 VSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARI 622

Query: 796 LLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKH 855
           L+D  +  N   L   TPL  A   GH     LLL  GA   A  + G TALH A    H
Sbjct: 623 LIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGH 682

Query: 856 VFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDD 905
           +  V+LL+   A V       +TA+  A  +     + ++V + V  L D
Sbjct: 683 LATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFD 732



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 97/356 (27%), Positives = 147/356 (41%), Gaps = 39/356 (10%)

Query: 527 NNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQ 586
           ++G + LHLA   G E+C K L+   + +   ++ N +G TPLH+A     +GV+E LL 
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLL---LNNANPNLSNRRGSTPLHMAVERRVRGVVELLLA 492

Query: 587 NGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQES 646
                           K ++N+K      A H + +   +SS   +     SV+ +  E 
Sbjct: 493 R---------------KISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEG 537

Query: 647 STSSFSSMSASSRQEETKKDYREVEKLLR----------AVADGDLEMVRYLLEWTEEDL 696
            T    +              R V+  L+          A   G L +V+ L +  +  +
Sbjct: 538 RTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK--QPGV 595

Query: 697 EDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLG-VNVTSQDGSSPLHVAALHG 755
                T+    P   H   Q         R+A++       VNV S    +PLHVAA  G
Sbjct: 596 SVNAQTLDGRTP--LHLAAQ-----RGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETG 648

Query: 756 RADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLI 815
                 LLL  GA   A  +D    LHLA + GH   VK L++  A    +     T L 
Sbjct: 649 HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALH 708

Query: 816 YACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQV 871
            A + GH E+V  L+     I+  + +G +ALH A   +H   VE LL HGA + +
Sbjct: 709 LAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINL 763



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 80/313 (25%), Positives = 138/313 (44%), Gaps = 19/313 (6%)

Query: 580 VIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSV 639
           V+   L+  ++    N    + L   L+S +   +E       R    S+ P     + +
Sbjct: 313 VVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPE-ELSRSSSESKLPSSGSGKRL 371

Query: 640 DSISQ-ESSTSSFSSMSASSRQEETKKDYREVE----KLLRAVADGDLEMVRYLLEWTEE 694
             +S  +S+ SS  S+S S  +E +  D    +    KL+ A+  GD   +  +L+   +
Sbjct: 372 SGVSSVDSAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQ--PQ 429

Query: 695 DLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAK-VPASGLGVNVTSQDGSSPLHVAAL 753
           D++ A D+ ++      H   +       Q+  AK +  +    N++++ GS+PLH+A  
Sbjct: 430 DVDLALDSGAS----LLHLAVEA-----GQEECAKWLLLNNANPNLSNRRGSTPLHMAVE 480

Query: 754 HGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTP 813
                ++ LLL    +  A++ DQ   LH A Q G     + LL+ NA  N+ D  G TP
Sbjct: 481 RRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTP 540

Query: 814 LIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLH-GASVQVL 872
           +  AC  G   +V +LL+ G  ++         LH A  + H+ +V+LL    G SV   
Sbjct: 541 MHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQ 600

Query: 873 NKRQRTAVDCAEQ 885
               RT +  A Q
Sbjct: 601 TLDGRTPLHLAAQ 613



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 95/373 (25%), Positives = 161/373 (43%), Gaps = 34/373 (9%)

Query: 405 IASGNQKEVERLLSQEDHDK--DTVQKMCHPLCFC--DDCEKLVSGRLNDPSVVTPFSRD 460
           I SG+  ++ ++L  +D D   D+   + H       ++C K +   LN+ +   P   +
Sbjct: 414 IVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLL--LNNAN---PNLSN 468

Query: 461 DRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKA 520
            RG TPLH+A       +++LL+++   VNA D    T LH A Q G +S T LLL   A
Sbjct: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNA 528

Query: 521 SAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGV 580
           S    D  G TP+H+AC +G E+ V+ L+   V+   + +  +    PLH AA  G+  +
Sbjct: 529 SVNEVDFEGRTPMHVACQHGQENIVRILLRRGVD---VSLQGKDAWLPLHYAAWQGHLPI 585

Query: 581 IETLL-QNGASTEIQNRLKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAPVQSPQ 636
           ++ L  Q G S   Q     TPL  A    + ++  ++             ++ P+    
Sbjct: 586 VKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLH--- 642

Query: 637 RSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDL 696
             V + +  +ST+       + ++  T   Y     L  A  +G L  V+ L+E   + L
Sbjct: 643 --VAAETGHTSTARLLLHRGAGKEAMTSDGY---TALHLAARNGHLATVKLLVEEKADVL 697

Query: 697 EDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGR 756
                  +A      H              + +   S   +++  + G S LH+AA    
Sbjct: 698 ARGPLNQTALHLAAAH----------GHSEVVEELVSADVIDLFDEQGLSALHLAAQGRH 747

Query: 757 ADLIPLLLKHGAN 769
           A  +  LL+HGA+
Sbjct: 748 AQTVETLLRHGAH 760



 Score = 34.3 bits (77), Expect = 0.63
 Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 1/68 (1%)

Query: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLH 517
           +R     T LH+AA  G + +++ LVS   +++  D  G + LHLA Q  +      LL 
Sbjct: 698 ARGPLNQTALHLAAAHGHSEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVETLLR 756

Query: 518 YKASAEVQ 525
           + A   +Q
Sbjct: 757 HGAHINLQ 764


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  104 bits (259), Expect = 5e-22
 Identities = 110/439 (25%), Positives = 178/439 (40%), Gaps = 55/439 (12%)

Query: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
           R++ G TPL +AA  G   ++  L+  GA  N  D    T L  A ++G+  +   LL  
Sbjct: 34  RNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKC 93

Query: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQ 578
             + E +D  G T L  AC  G  D V+ L+ +        +       P+  AA  G+ 
Sbjct: 94  GVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANP---SVTGLYSVYPIIWAAGRGHA 150

Query: 579 GVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRS 638
            ++  LLQNGA     ++   TPL  A     L  ++  HL         E    S    
Sbjct: 151 DIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVK--HLLAMGADVDQEG-ANSMTAL 207

Query: 639 VDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLED 698
           + ++    + S    +  +     T KD      L+ A  +G  E+V+ LL+        
Sbjct: 208 IVAVKGGYTQSVKEILKRNPNVNLTDKDGNTA--LMIASKEGHTEIVQDLLD-------- 257

Query: 699 AEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRAD 758
                                             +G  VN+  + G + L  A   G  +
Sbjct: 258 ----------------------------------AGTYVNIPDRSGDTVLIGAVRGGHVE 283

Query: 759 LIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYAC 818
           ++  LL+  A+   R  D    L+ A ++G+  +V+ +L  N         G TPLI A 
Sbjct: 284 IVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKAT 343

Query: 819 SGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVL---NKR 875
              + E+V LLL  GA ++A + KG+T LH A+  +   + ELLL +    ++L   NK 
Sbjct: 344 KMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKA 403

Query: 876 QRTA--VDCAEQNSKIMEL 892
             T   +DC+ Q S + ++
Sbjct: 404 GETPYNIDCSHQKSILTQI 422



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 94/377 (24%), Positives = 163/377 (43%), Gaps = 24/377 (6%)

Query: 539 YGHEDCVKALVYYDVESCR-LDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRL 597
           Y  E+ + AL    +E C+ +D  NE G TPL IAA  G   +++ L++NGA+  +++  
Sbjct: 12  YVEEENIPALKAL-LEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD 70

Query: 598 KETPLKCALNSKILSVMEAY---HLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSM 654
             T L  A     + ++E      ++ E R       +        +   E   S  ++ 
Sbjct: 71  NWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANP 130

Query: 655 SASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPL 714
           S +            V  ++ A   G  ++V  LL+   +        V+ +D     PL
Sbjct: 131 SVTGLYS--------VYPIIWAAGRGHADIVHLLLQNGAK--------VNCSDKYGTTPL 174

Query: 715 CQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARN 774
               +    +  +  + A G  V+    +  + L VA   G    +  +LK   N    +
Sbjct: 175 VWAARKGHLEC-VKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTD 233

Query: 775 ADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGA 834
            D    L +A ++GH ++V+ LLD+    N  D SG+T LI A  GGH E+V  LLQ  A
Sbjct: 234 KDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYA 293

Query: 835 SINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAE--QNSKIMEL 892
            I+       TAL+ AV + +  +V  +L      ++  K   T +  A   +N +++EL
Sbjct: 294 DIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVEL 353

Query: 893 LQVVPSCVASLDDVAET 909
           L    + V+++D   +T
Sbjct: 354 LLDKGAKVSAVDKKGDT 370



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 76/255 (29%), Positives = 112/255 (43%), Gaps = 15/255 (5%)

Query: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQV 792
           +G  VN + + G++PL  AA  G  + +  LL  GA+     A+    L +A + G+ Q 
Sbjct: 159 NGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQS 218

Query: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVI 852
           VK +L  N   N  D  GNT L+ A   GH E+V  LL  G  +N  +  G+T L  AV 
Sbjct: 219 VKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVR 278

Query: 853 EKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQN---SKIMELLQVVPSCVASLDDVAET 909
             HV +V  LL   A + +  +  +TA+  A +    + + ++LQ  P      D    T
Sbjct: 279 GGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNP------DTEICT 332

Query: 910 DRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARDRSVPNLTEG 969
              E   +K  K  N ++ +L  +   +      SA   KG T   I  R RS   L E 
Sbjct: 333 KDGETPLIKATKMRNIEVVELLLDKGAKV-----SAVDKKGDTPLHIAIRGRS-RKLAEL 386

Query: 970 SLHEPGRQSVTLRQN 984
            L  P    +  R N
Sbjct: 387 LLRNPKDGRLLYRPN 401


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score =  102 bits (254), Expect = 2e-21
 Identities = 97/321 (30%), Positives = 139/321 (43%), Gaps = 33/321 (10%)

Query: 673 LLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPA 732
           L  A  +G+ E++  LLE        A+  V   D +   PL         ++ +  V  
Sbjct: 53  LHHAALNGNTELISLLLE--------AQAAVDIKDNKGMRPL-HYAAWQGRKEPMKLVLK 103

Query: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQV 792
           +G  VN+ S +G  PLH+AA HG  D+  +LL+H +N    +     PL LAC+ G   V
Sbjct: 104 AGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGV 163

Query: 793 VKCLLDSNA-------KP-NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGN 844
           V+ LL SN        +P +  D +G +PL  A   GH +++ LLLQ G  IN     G 
Sbjct: 164 VQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG- 222

Query: 845 TALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQ---NSKIMELLQVVPSCVA 901
           TALHEA +     VV LLL  G +  V N   +TA+D   Q   +    E+ Q++    A
Sbjct: 223 TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASA 282

Query: 902 SLDDVAETDR-KEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHS-------AGQFKGKTS 953
           +L   A  D    Y    +  K    +  L   P  R    +H         G F     
Sbjct: 283 ALQVRATKDYCNNYDLTSLNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSSLG 342

Query: 954 REIMARDRS----VPNLTEGS 970
             I+ R  S     P+L +GS
Sbjct: 343 EAIVKRAGSRAGTEPSLPQGS 363



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 50/143 (34%), Positives = 80/143 (55%), Gaps = 5/143 (3%)

Query: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
           +D++G  PLH AA  G+   + L++  G+ VN     G  PLHLA Q G+  V+ +LL +
Sbjct: 78  KDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQH 137

Query: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRL-----DIGNEKGDTPLHIAA 573
           +++  + DN+G TPL LAC +G    V+ L+  ++ +  L     D  +  G +PLH+AA
Sbjct: 138 QSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAA 197

Query: 574 RWGYQGVIETLLQNGASTEIQNR 596
           + G+  +I  LLQ G     Q +
Sbjct: 198 KNGHIDIIRLLLQAGIDINRQTK 220



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 44/129 (34%), Positives = 67/129 (51%), Gaps = 3/129 (2%)

Query: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
           +D  G + LH AA+ G   LI LL+   A V+  D  G  PLH A  +G +    L+L  
Sbjct: 45  QDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKA 104

Query: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQ 578
            ++  +  + G+ PLHLA  +GH D  + L+ +    C +D     G TPL +A  +G  
Sbjct: 105 GSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVD---NSGKTPLDLACEFGRV 161

Query: 579 GVIETLLQN 587
           GV++ LL +
Sbjct: 162 GVVQLLLSS 170



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 42/132 (31%), Positives = 71/132 (53%), Gaps = 5/132 (3%)

Query: 474 GQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPL 533
           G+A L+    +K   VN  D  G + LH A   G   +  LLL  +A+ +++DN G  PL
Sbjct: 29  GKAKLLGS--TKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPL 86

Query: 534 HLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEI 593
           H A   G ++ +K ++        ++I +++G  PLH+AA+ G+  V E LLQ+ ++  +
Sbjct: 87  HYAAWQGRKEPMKLVL---KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCM 143

Query: 594 QNRLKETPLKCA 605
            +   +TPL  A
Sbjct: 144 VDNSGKTPLDLA 155



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 44/152 (28%), Positives = 79/152 (51%), Gaps = 4/152 (2%)

Query: 755 GRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPL 814
           G+A L+    K   N   ++ D    LH A   G+ +++  LL++ A  + KD  G  PL
Sbjct: 29  GKAKLLGSTKK--INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPL 86

Query: 815 IYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNK 874
            YA   G  E + L+L+ G+++N  +++G+  LH A    H  V E+LL H ++  +++ 
Sbjct: 87  HYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDN 146

Query: 875 RQRTAVDCAEQNSK--IMELLQVVPSCVASLD 904
             +T +D A +  +  +++LL     C A L+
Sbjct: 147 SGKTPLDLACEFGRVGVVQLLLSSNMCAALLE 178



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 43/152 (28%), Positives = 66/152 (43%), Gaps = 21/152 (13%)

Query: 456 PFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMV--------NATDYHGATPLHLACQKG 507
           P   D+ G TPL +A   G+  ++ LL+S             +ATD +G +PLHLA + G
Sbjct: 141 PCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNG 200

Query: 508 YQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDT 567
           +  +  LLL        Q  +G T LH A   G  + V+ L+   + +    + N    T
Sbjct: 201 HIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINA---HVRNTYSQT 256

Query: 568 PLHIAARWGYQGVIETLLQNGASTEIQNRLKE 599
            L I         +     + AS EI+  L+E
Sbjct: 257 ALDI---------VHQFTTSQASREIKQLLRE 279


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  100 bits (250), Expect = 6e-21
 Identities = 55/159 (34%), Positives = 86/159 (54%), Gaps = 2/159 (1%)

Query: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
           ++V  + G   LHVAA +G AD+  LL   G+N   ++ ++  PLH A   G++ V K L
Sbjct: 438 LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 497

Query: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
            ++    N K+  G TPL+ A + G+H++V  L +HGA +NA +  G+ ALH AV    +
Sbjct: 498 CEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQM 557

Query: 857 FVVELLLLHGASVQVLNKRQRTA--VDCAEQNSKIMELL 893
            V++ LL  G  V   ++   T   V C + N  I+  L
Sbjct: 558 EVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVAL 596



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 58/163 (35%), Positives = 88/163 (53%), Gaps = 2/163 (1%)

Query: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQV 792
           +G  VN+ +++G +PL  A+  G  D++  L +HGA+  A + D  + LHLA ++   +V
Sbjct: 500 AGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEV 559

Query: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVI 852
           +K LL      + +D  GNTPL  AC  G+  +V  L +   +++ SN  G T LH A  
Sbjct: 560 IKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAAN 619

Query: 853 EKHVFVVELLLLHGASVQVLNKRQRTAVDCA--EQNSKIMELL 893
              + VV  L L GASV+ L    +TA D A  EQ+  +  LL
Sbjct: 620 NGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 88/341 (25%), Positives = 139/341 (40%), Gaps = 50/341 (14%)

Query: 489 VNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKAL 548
           VN  + HG  PL +A   G   +  LL+   +  +VQD  G+  ++ A  +GH D +K L
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431

Query: 549 VYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNS 608
                  C LD+ ++ G+  LH+AAR+G+  V + L   G++  IQ++ +ETPL CA   
Sbjct: 432 ---SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCA--- 485

Query: 609 KILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYR 668
                  A+H  +   +   EA                      +++  +R+ ET     
Sbjct: 486 -------AWHGYYSVAKALCEAG--------------------CNVNIKNREGET----- 513

Query: 669 EVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLA 728
               LL A A G  ++V  L E   +        ++A D +  H            + + 
Sbjct: 514 ---PLLTASARGYHDIVECLAEHGAD--------LNACDKD-GHIALHLAVRRCQMEVIK 561

Query: 729 KVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQG 788
            + + G  V+   + G++PLHVA   G   ++  L +   N    N     PLHLA   G
Sbjct: 562 TLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNG 621

Query: 789 HFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALL 829
              VV+ L    A        G T    A S  H  +  LL
Sbjct: 622 ILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 53/134 (39%), Positives = 70/134 (52%), Gaps = 3/134 (2%)

Query: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
           ++  G TPL  A+  G   +++ L   GA +NA D  G   LHLA ++    V   LL  
Sbjct: 507 KNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 566

Query: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQ 578
               + QD +GNTPLH+AC  G+   V AL      +C LDI N+ G TPLH+AA  G  
Sbjct: 567 GCFVDYQDRHGNTPLHVACKDGNMPIVVALC---EANCNLDISNKYGRTPLHLAANNGIL 623

Query: 579 GVIETLLQNGASTE 592
            V+  L   GAS E
Sbjct: 624 DVVRYLCLMGASVE 637



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 51/160 (31%), Positives = 82/160 (51%), Gaps = 6/160 (3%)

Query: 446 GRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQ 505
           G L++  V  P   +  G  PL +AA CG   ++ LL+ +G+ ++  D  G+  ++ A +
Sbjct: 365 GSLSNYDVNQP---NKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAAR 421

Query: 506 KGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKG 565
            G+      L   K   +V+D +G   LH+A  YGH D  + L  +       +I +++ 
Sbjct: 422 HGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSF---GSNPNIQDKEE 478

Query: 566 DTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCA 605
           +TPLH AA  GY  V + L + G +  I+NR  ETPL  A
Sbjct: 479 ETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTA 518



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 51/159 (32%), Positives = 76/159 (47%), Gaps = 3/159 (1%)

Query: 456 PFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLL 515
           P  +D    TPLH AA  G  S+   L   G  VN  +  G TPL  A  +GY  +   L
Sbjct: 471 PNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECL 530

Query: 516 LHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARW 575
             + A     D +G+  LHLA      + +K L+    + C +D  +  G+TPLH+A + 
Sbjct: 531 AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL---SQGCFVDYQDRHGNTPLHVACKD 587

Query: 576 GYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVM 614
           G   ++  L +   + +I N+   TPL  A N+ IL V+
Sbjct: 588 GNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVV 626



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 29/84 (34%), Positives = 40/84 (47%)

Query: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
           +D  G+TPLHVA   G   ++  L      ++ ++ +G TPLHLA   G   V   L   
Sbjct: 573 QDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLM 632

Query: 519 KASAEVQDNNGNTPLHLACTYGHE 542
            AS E    +G T   LA +  HE
Sbjct: 633 GASVEALTTDGKTAEDLARSEQHE 656



 Score = 30.8 bits (68), Expect = 7.0
 Identities = 20/53 (37%), Positives = 26/53 (49%)

Query: 463 GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLL 515
           G TPLH+AA  G   ++  L   GA V A    G T   LA  + ++ V  LL
Sbjct: 610 GRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score =  100 bits (248), Expect = 9e-21
 Identities = 93/324 (28%), Positives = 140/324 (43%), Gaps = 48/324 (14%)

Query: 569  LHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVM--------EAYHLS 620
            L + +  GY  ++  LL+ GA+ +  +    TPL  A  +  LS++        +  HL 
Sbjct: 889  LCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLD 948

Query: 621  FERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADG 680
               +     A ++     V  + Q   T       A  +Q   KK +   + L+ A + G
Sbjct: 949  KNGQCALVHAALRGHLEVVKFLIQCDWTM------AGQQQGVFKKSHAIQQALIAAASMG 1002

Query: 681  DLEMVRYLLEWTEEDLEDAEDT-VSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNV 739
              E+V YLL+  E+D E+ E   +++ D                                
Sbjct: 1003 YTEIVSYLLDLPEKDEEEVERAQINSFD-------------------------------- 1030

Query: 740  TSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDS 799
             S  G + L  AA  G+ ++  LLL+ GA     N   AVPL    +QGH+Q+V  LL  
Sbjct: 1031 -SLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTH 1089

Query: 800  NAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVV 859
             A  N  D  G TPL+ A S GH   V  LL  GASI   + +G TAL  A ++ H+ VV
Sbjct: 1090 GADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVV 1149

Query: 860  ELLLLHGASVQVLNKRQRTAVDCA 883
              L+ +GA+    +K  RT +D A
Sbjct: 1150 RSLVDNGAATDHADKNGRTPLDLA 1173



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 52/153 (33%), Positives = 74/153 (48%), Gaps = 3/153 (1%)

Query: 462  RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
            RG  PL      G   ++DLL++ GA VN  D  G TPL +A  +G+      LL   AS
Sbjct: 1066 RGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGAS 1125

Query: 522  AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
              + D  G T L  AC  GH   V++LV         D  ++ G TPL +AA +G   V+
Sbjct: 1126 IALMDKEGLTALSWACLKGHLSVVRSLV---DNGAATDHADKNGRTPLDLAAFYGDAEVV 1182

Query: 582  ETLLQNGASTEIQNRLKETPLKCALNSKILSVM 614
            + L+ +GA  E  +     PL  A+  +  SV+
Sbjct: 1183 QFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVV 1215



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 96/389 (24%), Positives = 148/389 (38%), Gaps = 71/389 (18%)

Query: 467  LHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQD 526
            L V +  G   ++ LL+  GA V+A+   G TPL  A   GY S+ +LL   +A  +  D
Sbjct: 889  LCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLD 948

Query: 527  NNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKG--------DTPLHIAARWGYQ 578
             NG   L  A   GH + VK L+  D        G ++G           L  AA  GY 
Sbjct: 949  KNGQCALVHAALRGHLEVVKFLIQCDWTMA----GQQQGVFKKSHAIQQALIAAASMGY- 1003

Query: 579  GVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRS 638
                        TEI + L + P                       +K  E   ++   S
Sbjct: 1004 ------------TEIVSYLLDLP-----------------------EKDEEEVERAQINS 1028

Query: 639  VDSISQESSTSSFSS--------MSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLE 690
             DS+  E++ ++ +         +         + + R    L   V  G  ++V  LL 
Sbjct: 1029 FDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLT 1088

Query: 691  WTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVP---ASGLGVNVTSQDGSSP 747
               +        V+ AD +   PL      A ++  L  V    A G  + +  ++G + 
Sbjct: 1089 HGAD--------VNMADKQGRTPLMM----AASEGHLGTVDFLLAQGASIALMDKEGLTA 1136

Query: 748  LHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKD 807
            L  A L G   ++  L+ +GA     + +   PL LA   G  +VV+ L+D  A     D
Sbjct: 1137 LSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVD 1196

Query: 808  LSGNTPLIYACSGGHHELVALLLQHGASI 836
             SG  PL  A    +  +V  LL+ GA I
Sbjct: 1197 YSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1225



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 48/130 (36%), Positives = 65/130 (50%), Gaps = 3/130 (2%)

Query: 460  DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
            D +G TPL +AA  G    +D L+++GA +   D  G T L  AC KG+ SV   L+   
Sbjct: 1097 DKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNG 1156

Query: 520  ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQG 579
            A+ +  D NG TPL LA  YG  + V+ LV +      +D     G  PL  A       
Sbjct: 1157 AATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDY---SGMRPLDRAVGCRNTS 1213

Query: 580  VIETLLQNGA 589
            V+ TLL+ GA
Sbjct: 1214 VVVTLLKKGA 1223



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 45/143 (31%), Positives = 73/143 (51%), Gaps = 3/143 (2%)

Query: 463  GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASA 522
            G T L  AA  G+  +  LL+ +GA V   +  GA PL    ++G+  +  LLL + A  
Sbjct: 1034 GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADV 1093

Query: 523  EVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIE 582
             + D  G TPL +A + GH   V  L+    +   + + +++G T L  A   G+  V+ 
Sbjct: 1094 NMADKQGRTPLMMAASEGHLGTVDFLL---AQGASIALMDKEGLTALSWACLKGHLSVVR 1150

Query: 583  TLLQNGASTEIQNRLKETPLKCA 605
            +L+ NGA+T+  ++   TPL  A
Sbjct: 1151 SLVDNGAATDHADKNGRTPLDLA 1173



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 51/187 (27%), Positives = 83/187 (44%), Gaps = 19/187 (10%)

Query: 737  VNVTSQDGSSPLHVAALHGRADLIPLLLK-----HGANAGARNADQAVPLHL--ACQQGH 789
            V+   ++G   L  AAL G  +++  L++      G   G      A+   L  A   G+
Sbjct: 944  VDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGY 1003

Query: 790  FQVVKCLLDSNAKPNKK----------DLSGNTPLIYACSGGHHELVALLLQHGASINAS 839
             ++V  LLD   K  ++           L G T L  A   G  E+  LLL+ GA++   
Sbjct: 1004 TEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQP 1063

Query: 840  NNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKI--MELLQVVP 897
            N +G   L   V + H  +V+LLL HGA V + +K+ RT +  A     +  ++ L    
Sbjct: 1064 NRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQG 1123

Query: 898  SCVASLD 904
            + +A +D
Sbjct: 1124 ASIALMD 1130



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 30/94 (31%), Positives = 52/94 (55%), Gaps = 2/94 (2%)

Query: 789 HFQVVKCLLDSNAKPN-KKDLSGNTPLIYACSG-GHHELVALLLQHGASINASNNKGNTA 846
           + +V + L+   A  N + ++  N P++   S  G+ E+VALLL+ GA+++AS+  G T 
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921

Query: 847 LHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAV 880
           L  A    ++ +V LL    A V  L+K  + A+
Sbjct: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,072,506
Number of Sequences: 37866
Number of extensions: 1845657
Number of successful extensions: 12817
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 362
Number of HSP's successfully gapped in prelim test: 76
Number of HSP's that attempted gapping in prelim test: 5504
Number of HSP's gapped (non-prelim): 3465
length of query: 1050
length of database: 18,247,518
effective HSP length: 113
effective length of query: 937
effective length of database: 13,968,660
effective search space: 13088634420
effective search space used: 13088634420
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.