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Search of human proteins with 229089140
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
(513 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 1020 0.0
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 145 7e-35
gi|109150416 peroxidasin [Homo sapiens] 135 1e-31
gi|13375646 leucine rich repeat and fibronectin type III domain ... 131 1e-30
gi|11321571 slit homolog 3 [Homo sapiens] 129 6e-30
gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 128 1e-29
gi|149773484 leucine rich repeat and fibronectin type III domain... 127 2e-29
gi|188528675 slit homolog 1 [Homo sapiens] 127 2e-29
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 125 9e-29
gi|27363458 leucine rich repeat and fibronectin type III domain ... 124 2e-28
gi|14149694 retina specific protein PAL [Homo sapiens] 124 2e-28
gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens] 122 8e-28
gi|4759146 slit homolog 2 [Homo sapiens] 122 8e-28
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 119 9e-27
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 118 1e-26
gi|51317373 netrin-G1 ligand [Homo sapiens] 118 1e-26
gi|194306623 immunoglobulin superfamily containing leucine-rich ... 117 2e-26
gi|194306621 immunoglobulin superfamily containing leucine-rich ... 117 2e-26
gi|39930401 immunoglobulin superfamily containing leucine-rich r... 117 2e-26
gi|194306618 immunoglobulin superfamily containing leucine-rich ... 117 2e-26
gi|126517478 peroxidasin homolog-like [Homo sapiens] 117 3e-26
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens] 117 3e-26
gi|61966761 leucine rich repeat containing 26 [Homo sapiens] 116 4e-26
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 113 4e-25
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 113 4e-25
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 113 4e-25
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho... 112 6e-25
gi|88702793 slit-like 2 [Homo sapiens] 111 1e-24
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 111 2e-24
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 109 7e-24
>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
Length = 513
Score = 1020 bits (2637), Expect = 0.0
Identities = 513/513 (100%), Positives = 513/513 (100%)
Query: 1 MALRAPALLPLLLLLLPLRAAGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDN 60
MALRAPALLPLLLLLLPLRAAGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDN
Sbjct: 1 MALRAPALLPLLLLLLPLRAAGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDN 60
Query: 61 NIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVG 120
NIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVG
Sbjct: 61 NIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVG 120
Query: 121 LAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRN 180
LAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRN
Sbjct: 121 LAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRN 180
Query: 181 QLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPP 240
QLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPP
Sbjct: 181 QLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPP 240
Query: 241 RLALQSLLDVSHSSLICIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPR 300
RLALQSLLDVSHSSLICIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPR
Sbjct: 241 RLALQSLLDVSHSSLICIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPR 300
Query: 301 EGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRL 360
EGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRL
Sbjct: 301 EGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRL 360
Query: 361 LVNASRQQPQQPAQPPPPAARPAGSEPRPEAGSMAFRALGVATQTAIAAAIALLALTALL 420
LVNASRQQPQQPAQPPPPAARPAGSEPRPEAGSMAFRALGVATQTAIAAAIALLALTALL
Sbjct: 361 LVNASRQQPQQPAQPPPPAARPAGSEPRPEAGSMAFRALGVATQTAIAAAIALLALTALL 420
Query: 421 LVAMICRRRRRRKKARGPPGEGALFVNDYLDGPCTFAQLEELRDERGHEMFVINRSKPLF 480
LVAMICRRRRRRKKARGPPGEGALFVNDYLDGPCTFAQLEELRDERGHEMFVINRSKPLF
Sbjct: 421 LVAMICRRRRRRKKARGPPGEGALFVNDYLDGPCTFAQLEELRDERGHEMFVINRSKPLF 480
Query: 481 AEGPAEAPADCGPEQGAGPGLRVPPPVAYEIHC 513
AEGPAEAPADCGPEQGAGPGLRVPPPVAYEIHC
Sbjct: 481 AEGPAEAPADCGPEQGAGPGLRVPPPVAYEIHC 513
>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
Length = 420
Score = 145 bits (367), Expect = 7e-35
Identities = 124/375 (33%), Positives = 160/375 (42%), Gaps = 64/375 (17%)
Query: 5 APALLPLLLLLLPLRAAGCPAACRCYSA--TVECGALRLRVVPLGIPPGTQTLFLQDNNI 62
A A L L+LL LPL A CP C CYS+ TV C A VPL +PP TQ LFLQ+N I
Sbjct: 13 ASACLLLMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLI 72
Query: 63 ARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNR-LRGLRSGAFVGL 121
L PG + L L+L +N+L + G FR L EL L NR LR L F GL
Sbjct: 73 RTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGL 130
Query: 122 AQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALA-------------- 167
+L+ L+L QL+ L F L LQ L+LQENS+ L+D A
Sbjct: 131 ERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNR 190
Query: 168 ----------------------------------GLSSLALLDLSRNQLGTISREALQPL 193
GLS L +L L N L ++ EAL L
Sbjct: 191 LRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADL 250
Query: 194 ASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHS 253
SL+ LRL NPW CDC L AW + + ++S D + CA PP + L + +
Sbjct: 251 PSLEFLRLNANPWACDCRARPLWAWFQ---RARVSSSD--VTCATPPERQGRDLRALREA 305
Query: 254 SLICIPPSVHVQP-LELTANLGEDLRVACQASGYP--QPLVTWRKVP-QPREGRPRAQAQ 309
PP+ +P N + +G P P +R +P + GR A
Sbjct: 306 DFQACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADPSTLYRDLPAEDSRGRQGGDAP 365
Query: 310 LEGGLLGLGGHSASD 324
E GG+ D
Sbjct: 366 TEDDY--WGGYGGED 378
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 135 bits (339), Expect = 1e-31
Identities = 96/335 (28%), Positives = 141/335 (42%), Gaps = 41/335 (12%)
Query: 21 AGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLY 80
AGCP+ C C+ TV C L L VP + P T L L+ N I ++PGA L L L
Sbjct: 34 AGCPSRCLCFRTTVRCMHLLLEAVP-AVAPQTSILDLRFNRIREIQPGAFRRLRNLNTLL 92
Query: 81 LHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDF 140
L+NN ++ + +GAF L L L N ++ + AF GLA L LYL NQ+ L
Sbjct: 93 LNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPD 152
Query: 141 TFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLR 200
+F HLP+L+ L L N I L GT + L S++ LR
Sbjct: 153 SFQHLPKLERLFLHNNRITHLVP-------------------GTFNH-----LESMKRLR 188
Query: 201 LTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPP 260
L N CDC + WL +K + + +C P R+ +S+ ++ L C P
Sbjct: 189 LDSNTLHCDCEILWLADLLKTYAES--GNAQAAAICEYPRRIQGRSVATITPEELNCERP 246
Query: 261 SVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGH 320
+ +P + G + C+A G P+P + W + + ++ L
Sbjct: 247 RITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNL---------- 296
Query: 321 SASDTGSGMLFLSNITLAHAGKYECEASNAGGAAR 355
G L + N G Y+C A N G +
Sbjct: 297 ----LDDGTLMIQNTQETDQGIYQCMAKNVAGEVK 327
Score = 45.4 bits (106), Expect = 1e-04
Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 16/98 (16%)
Query: 266 PLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGHSASDT 325
P + T +G ++++ C + G P+P +TW K G+ +
Sbjct: 531 PSDTTVEVGANVQLPCSSQGEPEPAITWNK----------------DGVQVTESGKFHIS 574
Query: 326 GSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVN 363
G L ++++ A AG+YEC A N G+A V L VN
Sbjct: 575 PEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVN 612
Score = 40.0 bits (92), Expect = 0.005
Identities = 29/103 (28%), Positives = 44/103 (42%), Gaps = 16/103 (15%)
Query: 260 PSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGG 319
P V P + G+ + C+A G P P++ W K +Q ++ L L
Sbjct: 433 PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTK--------GGSQLSVDRRHLVLS- 483
Query: 320 HSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLV 362
SG L +S + L G+YEC+A N G+ +V L V
Sbjct: 484 -------SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTV 519
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 131 bits (330), Expect = 1e-30
Identities = 140/467 (29%), Positives = 181/467 (38%), Gaps = 87/467 (18%)
Query: 7 ALLPLLLLLLPLRAAG----------CPAACRCYSAT----VECGALRLRVVPLGIPPGT 52
A+LPLLL LLPL A CP CRC + + V C L VP +
Sbjct: 2 AILPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRA 61
Query: 53 QTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRG 112
L L DN IA + LA + L L L N++R + AGAF L L L NRL
Sbjct: 62 AELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTS 121
Query: 113 LRSGAFVGLAQLRVLYLAGNQLARL--------------LDFTFLHLPRL---------- 148
L G GL LR L L+ NQLA L LD ++ +L +L
Sbjct: 122 LGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGN 181
Query: 149 -QELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREAL---QPL--------ASL 196
L L N + + A + L LA LD++ N+L TI + L PL AS
Sbjct: 182 VNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASA 241
Query: 197 QVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLI 256
VL NP C+C L WL R L D CA PP L + V +
Sbjct: 242 LVLAFGGNPLHCNCELVWL---------RRLAREDDLEACASPPALGGRYFWAVGEEEFV 292
Query: 257 CIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLG 316
C PP V + L G + C+A G P+P V W +G LLG
Sbjct: 293 CEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRW--------------VSPQGRLLG 338
Query: 317 LGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRL---------LVNASRQ 367
A +G L L G + C A+NA G A L L N++
Sbjct: 339 -NSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSC 397
Query: 368 QPQQPAQP---PPPAARPAGSEPRPEAGSMAFRALGVATQTAIAAAI 411
P + P PP+A A ++ + G R + V A AA +
Sbjct: 398 DPPRDGDPDALTPPSAASASAKV-ADTGPPTDRGVQVTEHGATAALV 443
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 129 bits (324), Expect = 6e-30
Identities = 88/273 (32%), Positives = 129/273 (47%), Gaps = 9/273 (3%)
Query: 2 ALRAPALLPLLL--LLLPLRAAGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQD 59
A+RA L L L +L A CP C C +A+V+C L LR VP GIP + L L
Sbjct: 11 AVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDR 70
Query: 60 NNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFV 119
NNI R+ A L LR L+L +N + +E GAF+ +L L L N+L+ L F
Sbjct: 71 NNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQ 130
Query: 120 GLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSR 179
+L L L+ NQ+ + F + ++ L L N I +ED A L L +L L+
Sbjct: 131 STPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNN 190
Query: 180 NQLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEP 239
N + I + + ++ LRL N CDC L WL W+++ + + +C P
Sbjct: 191 NNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQ-----RRTVGQFTLCMAP 245
Query: 240 PRLALQSLLDVSHSSLICIPPSVHVQPLELTAN 272
L ++ DV +C P+ H +P AN
Sbjct: 246 VHLRGFNVADVQKKEYVC--PAPHSEPPSCNAN 276
Score = 116 bits (290), Expect = 6e-26
Identities = 74/235 (31%), Positives = 113/235 (48%), Gaps = 28/235 (11%)
Query: 23 CPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLH 82
CP CRC V+C +L +P +P L L DN ++ LE
Sbjct: 505 CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEA--------------- 549
Query: 83 NNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTF 142
G F+ P L ++ L++N+++ +R GAF G A ++ L L GNQL + F
Sbjct: 550 --------TGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVF 601
Query: 143 LHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLT 202
L L+ L L+ N I + + AGLSS+ LL L N++ TI+ A L SL + L
Sbjct: 602 RGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLL 661
Query: 203 ENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLIC 257
NP+ C+C L WLG W+++ +R+++ R C +P L + DV+ C
Sbjct: 662 SNPFNCNCHLAWLGKWLRK--RRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTC 711
Score = 107 bits (266), Expect = 3e-23
Identities = 69/235 (29%), Positives = 104/235 (44%), Gaps = 29/235 (12%)
Query: 23 CPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLH 82
CP+ C C + V+C L +P +P G + + L
Sbjct: 280 CPSPCTCSNNIVDCRGKGLMEIPANLPEG------------------------IVEIRLE 315
Query: 83 NNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTF 142
NS++A+ AGAF +L + ++ N++ + AF GL L L L GN++ + F
Sbjct: 316 QNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLF 375
Query: 143 LHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLT 202
L LQ L L N I L L +L LL L N+L TIS+ PL S+Q L L
Sbjct: 376 DGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLA 435
Query: 203 ENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLIC 257
+NP+ CDC L WL ++++ +R C+ P RLA + + + C
Sbjct: 436 QNPFVCDCHLKWLADYLQDNPIETSGAR-----CSSPRRLANKRISQIKSKKFRC 485
Score = 80.9 bits (198), Expect = 3e-15
Identities = 63/238 (26%), Positives = 90/238 (37%), Gaps = 54/238 (22%)
Query: 23 CPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLH 82
CP C C V C LR +P G+P + LYL
Sbjct: 725 CPEQCTCMETVVRCSNKGLRALPRGMPKD------------------------VTELYLE 760
Query: 83 NNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTF 142
N L A+ PR L L L ++ L+ N ++ L ++TF
Sbjct: 761 GNHLTAV--------PRELS-----------------ALRHLTLIDLSNNSISMLTNYTF 795
Query: 143 LHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLT 202
++ L L L N + + A GL SL +L L N + ++ + L SL L L
Sbjct: 796 SNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALG 855
Query: 203 ENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPP 260
NP CDC+L WL W+K G + +R C+ P +A + LL C P
Sbjct: 856 TNPLHCDCSLRWLSEWVKAGYKEPGIAR-----CSSPEPMADRLLLTTPTHRFQCKGP 908
>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
Length = 473
Score = 128 bits (322), Expect = 1e-29
Identities = 124/426 (29%), Positives = 167/426 (39%), Gaps = 102/426 (23%)
Query: 20 AAGCPAACRCYS---ATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAAL 76
AA CP AC CY+ T C L+ VP+GIP +Q +FL N I+ + + L
Sbjct: 24 AAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNL 83
Query: 77 RRLYLHNNSLRALEAGAFRAQPRLLELALTSNR-------------------------LR 111
L+LH+N L ++A AF L +L L+ N L+
Sbjct: 84 TILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQ 143
Query: 112 GLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSS 171
L G F GLA L+ LYL N L L D TF L L L L N I + ++A GL S
Sbjct: 144 ELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHS 203
Query: 172 L----------------ALLDLSR--------NQLGTISREALQPLASLQVLRLTENPWR 207
L A DL R N L + EAL PL +LQ LRL +NPW
Sbjct: 204 LDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWV 263
Query: 208 CDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPPSVHVQPL 267
CDC L AW+++ ++ C+ P RLA + L
Sbjct: 264 CDCRARPLWAWLQK-----FRGSSSEVPCSLPQRLAGRDL-------------------K 299
Query: 268 ELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRA---QAQLEGGLLGLGGHSASD 324
L AN DL+ A+G P+ T R + G P+ A + +L G +++
Sbjct: 300 RLAAN---DLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASA- 355
Query: 325 TGSGMLFLSNITLAHAGKYECEASNAGGAARV---PFRLLVNASRQQPQQPAQPPPPAAR 381
N + N G + PF L + A+PP A R
Sbjct: 356 --------GNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGS--------AEPPLTAVR 399
Query: 382 PAGSEP 387
P GSEP
Sbjct: 400 PEGSEP 405
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 127 bits (320), Expect = 2e-29
Identities = 130/450 (28%), Positives = 177/450 (39%), Gaps = 68/450 (15%)
Query: 6 PALLPLLLLLLPLRAAG--CPAACRCYSA----TVECGALRLRVVPLGIPPGTQTLFLQD 59
PA LP LLLL + G CP C C + T+ C L VP I L L D
Sbjct: 15 PAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTD 74
Query: 60 NNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFV 119
N IA + A + +L L L N++ + AGAF L L L SNRL +R
Sbjct: 75 NFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLR 134
Query: 120 GLAQLRVLYLAGNQLARLLDFTF-LHLPRLQELHLQENSIELLEDQALAGLSSLALLDLS 178
GL LR L L NQ+ R+ F L +++L L N++E L +A+ + +L L L
Sbjct: 135 GLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLD 194
Query: 179 RNQLGTISREALQPLASLQVLRLTEN--------------------------------PW 206
N + I+ L L L +T N P
Sbjct: 195 HNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGGNPL 254
Query: 207 RCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPPSVHVQP 266
C+C L WL R LT D CA P L + + +C PP + Q
Sbjct: 255 HCNCELLWL---------RRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQA 305
Query: 267 LELTANL-GEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGHSASDT 325
+ G+ + + C+A G P+P+V W +G LLG +
Sbjct: 306 GGRALVVEGQAVSLRCRAVGDPEPVVHW--------------VAPDGRLLGNSSRTRV-R 350
Query: 326 GSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPP---PAARP 382
G G L ++ TL +G + C ASNA G A P + V PA PPP P +
Sbjct: 351 GDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSD 410
Query: 383 AGSEPRPEAG-SMAFRALGVATQTAIAAAI 411
+ RP A S A R L A T+ + I
Sbjct: 411 IATPGRPGANDSAAERRLVAAELTSNSVLI 440
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 127 bits (319), Expect = 2e-29
Identities = 81/236 (34%), Positives = 114/236 (48%), Gaps = 30/236 (12%)
Query: 23 CPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEP-GALAPLAALRRLYL 81
CP CRC + VEC +L+L +P IP T L L +N I+ LE G L L+++ L
Sbjct: 513 CPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINL 572
Query: 82 HNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFT 141
NN + +E GAF + EL LT+N+L +RSG F GL LR L L N+
Sbjct: 573 SNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNR-------- 624
Query: 142 FLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRL 201
I + + + GL ++ LL L NQ+ T+S A L SL L L
Sbjct: 625 ----------------ISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNL 668
Query: 202 TENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLIC 257
NP+ C+C L WLG W+++ ++++T R C P L L DV+ C
Sbjct: 669 LANPFNCNCQLAWLGGWLRK--RKIVTGNPR---CQNPDFLRQIPLQDVAFPDFRC 719
Score = 115 bits (289), Expect = 7e-26
Identities = 77/240 (32%), Positives = 108/240 (45%), Gaps = 5/240 (2%)
Query: 18 LRAAGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALR 77
L A+ CPA C C TV+C L+ +P IP T+ L L NNI R+ A L LR
Sbjct: 29 LGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLR 88
Query: 78 RLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARL 137
L L N + A+E GAF L L L N+L L F L L L+ N + +
Sbjct: 89 VLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAI 148
Query: 138 LDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQ 197
F L+ L L +N I +E+ A L L +L L+ N + TI + + L+
Sbjct: 149 PRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLR 208
Query: 198 VLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLIC 257
RL N CDC L WL W+++ L ++ C+ P L ++ +V S C
Sbjct: 209 TFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQ-----CSGPASLRGLNVAEVQKSEFSC 263
Score = 108 bits (270), Expect = 1e-23
Identities = 88/347 (25%), Positives = 142/347 (40%), Gaps = 40/347 (11%)
Query: 18 LRAAGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALR 77
L + CPA C C + V+C L +P +P + L+ N I + PGA +P LR
Sbjct: 277 LSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLR 336
Query: 78 RLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARL 137
R+ L NN + + AF+ L L L N++ L G F GL L++L
Sbjct: 337 RIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLL--------- 387
Query: 138 LDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQ 197
L N I + A L +L+LL L N++ ++++ L ++Q
Sbjct: 388 ---------------LNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQ 432
Query: 198 VLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLIC 257
L L +NP+ CDC L WL +++ +R CA P RLA + + + C
Sbjct: 433 TLHLAQNPFICDCNLKWLADFLRTNPIETSGAR-----CASPRRLANKRIGQIKSKKFRC 487
Query: 258 IPPSVHVQP----LELTANLGEDL----RVACQASGYPQPLVTWRKVPQPREGRPRAQAQ 309
+ P +L + D+ + C+A+ + K+P E P++ A+
Sbjct: 488 SAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIP---ERIPQSTAE 544
Query: 310 LEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARV 356
L + A+ + L I L++ E E GAA V
Sbjct: 545 LRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASV 591
Score = 96.3 bits (238), Expect = 6e-20
Identities = 82/280 (29%), Positives = 111/280 (39%), Gaps = 73/280 (26%)
Query: 23 CPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLH 82
CP C C V C LR +P GIP L+L D N L PG L+ L+ + L
Sbjct: 734 CPQECACLDTVVRCSNKHLRALPKGIPKNVTELYL-DGNQFTLVPGQLSTFKYLQLVDLS 792
Query: 83 NNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTF 142
NN + +L +F +L L L+ N L+ + AF GL LR+L L G
Sbjct: 793 NNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHG----------- 841
Query: 143 LHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLT 202
N I L++ A ++SL+ L + N
Sbjct: 842 -------------NDISTLQEGIFADVTSLSHLAIGAN---------------------- 866
Query: 203 ENPWRCDCALHWLGAWIKEG----------------GQRLLTSRDRKIMCAEPPRLALQS 246
P CDC L WL +W+K G G+ LLT+ +K C PP LA+Q+
Sbjct: 867 --PLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQA 924
Query: 247 LLDVSHSSLICIPPSVHVQPLELTANLGEDLRVACQASGY 286
D+ SS + H PLE+ R AC SGY
Sbjct: 925 KCDLCLSSPCQNQGTCHNDPLEV-------YRCAC-PSGY 956
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 125 bits (314), Expect = 9e-29
Identities = 86/196 (43%), Positives = 106/196 (54%), Gaps = 3/196 (1%)
Query: 9 LPLLLL-LLPLRAAGCPAACRCYSAT--VECGALRLRVVPLGIPPGTQTLFLQDNNIARL 65
LPLLLL P A GCPA C C T V C RL VP GIP T+ L L N I L
Sbjct: 10 LPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCL 69
Query: 66 EPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLR 125
PG LA L AL L L N++ +E GAF PRL L L N+L+ + G F L L
Sbjct: 70 NPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLT 129
Query: 126 VLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTI 185
+L L+ N+L LLD+TF L L+ L + +N + + +A AGL +L L L R L +
Sbjct: 130 LLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTAL 189
Query: 186 SREALQPLASLQVLRL 201
S E+L L SL LRL
Sbjct: 190 SGESLGHLRSLGALRL 205
Score = 114 bits (286), Expect = 2e-25
Identities = 118/400 (29%), Positives = 168/400 (42%), Gaps = 64/400 (16%)
Query: 37 GALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHN-NSLRALEAGAFR 95
GALRLR + + L+D N RL PG L L + N L + AG+ R
Sbjct: 201 GALRLRHLAIAS--------LEDQNFRRL-PGLL-------HLEIDNWPLLEEVAAGSLR 244
Query: 96 AQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQE 155
L L++T + + + A A L L L+ N ++ + +F L RL+ELHL
Sbjct: 245 GL-NLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAG 303
Query: 156 NSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALHWL 215
+ ++E QA GL + LL+LS N L T+ + +L+ LR+ NP CDC L W+
Sbjct: 304 ALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWI 363
Query: 216 GAWIKEGGQRLLTSRDRKIMCAEPPRL---ALQSLLD-VSHSSLICIPPSVHVQPLE-LT 270
++ L R CA P + AL++L D V +C P + + L+ +T
Sbjct: 364 -----VQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVT 418
Query: 271 ANLGEDLRVACQASGYPQPLVTW-----RKVPQPREGRPRAQAQLEGGLLGLGGHSASDT 325
A GED+R C+A G P P V W R V GR R L GG L + D+
Sbjct: 419 ATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARV---LPGGTLEIQDARPQDS 475
Query: 326 GSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPPPAARPAGS 385
G+ Y C ASNAGG L V P PAA
Sbjct: 476 GT---------------YTCVASNAGGNDTYFATLTVR------------PEPAANRTPG 508
Query: 386 EPRPEAGSMAFRALGVATQTAIAAAIALLALTALLLVAMI 425
E E A RA T ++ A+ + ++L +
Sbjct: 509 EAHNET-LAALRAPLDLTTILVSTAMGCITFLGVVLFCFV 547
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 124 bits (312), Expect = 2e-28
Identities = 119/390 (30%), Positives = 154/390 (39%), Gaps = 62/390 (15%)
Query: 10 PLLLLLLPLRAAGCPAACRCY----SATVECGALRLRVVPLGIPPGTQTLFLQDNNIARL 65
PLLLLLL AA CP C C S + C L VP + T L L DN I L
Sbjct: 4 PLLLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQAL 63
Query: 66 EPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLR 125
P + L L L N++ + A AF L L L NRL L +G+ G L+
Sbjct: 64 GPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQ 123
Query: 126 VLYLAGNQLARL--------------LDFTFLHL-----------PRLQELHLQENSIEL 160
L L+GNQL R+ LD ++ +L P L L+L N I+
Sbjct: 124 HLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDA 183
Query: 161 LEDQALAGLSSLALLDLSRNQLGTISREAL-------QPLASLQVLRLTENPWRCDCALH 213
L A A L L+ LDL+ N+L T++ + L + + VL + NP C+C L
Sbjct: 184 LPPGAFAQLGQLSRLDLTSNRLATLAPDPLFSRGRDAEASPAPLVLSFSGNPLHCNCELL 243
Query: 214 WLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPPSVHVQPLELTANL 273
WL R L D CA PP LA + V C PP + L
Sbjct: 244 WL---------RRLARPDDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQRLWVLE 294
Query: 274 GEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLS 333
G+ + C+A G P P + W G G L +G A D
Sbjct: 295 GQRATLRCRALGDPAPTMHWVGPDDRLVGNSSRARAFPNGTLEIGVTGAGD--------- 345
Query: 334 NITLAHAGKYECEASNAGG--AARVPFRLL 361
AG Y C A+N G ARV R+L
Sbjct: 346 ------AGGYTCIATNPAGEATARVELRVL 369
>gi|14149694 retina specific protein PAL [Homo sapiens]
Length = 623
Score = 124 bits (311), Expect = 2e-28
Identities = 119/407 (29%), Positives = 167/407 (41%), Gaps = 70/407 (17%)
Query: 5 APALLPLLLLLLPLRAAG-CPAACRCY---------SATVECGALRLRVVPLGIPPGTQT 54
A +L LL L P +A G CP+ C C + TV C + + P IPP T
Sbjct: 4 ALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSR 63
Query: 55 LFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLR 114
L L+ I R+ A PL L +L+L N+L L A R
Sbjct: 64 LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLR------------------- 104
Query: 115 SGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLAL 174
GL +LR L L GN+LA P+L+ L LQ N + + +A L +L
Sbjct: 105 -----GLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTF 159
Query: 175 LDLSRNQLGTISREALQPLASLQ------------VLRLTENPWRCDCALHWLGAWIKEG 222
LDLS NQL + +E + A L+ VL L +NPW CDC L+ L + +G
Sbjct: 160 LDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDL-VHLLDG 218
Query: 223 GQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSL---ICIPPSVHVQPLELTANLGEDLRV 279
L + ++ CA P +SL V+ S L C P +H + + LG +
Sbjct: 219 WAPNLAFIETELRCASP-----RSLAGVAFSQLELRKCQGPELHPGVASIRSLLGGTALL 273
Query: 280 ACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAH 339
C A+G P P ++WR+ GRP L G S G+ L ++H
Sbjct: 274 RCGATGVPGPEMSWRRA----NGRP---------LNGTVHQEVSSDGTSWTLLGLPAVSH 320
Query: 340 --AGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPPPAARPAG 384
+G Y C+A N GA+ L+V + P AR G
Sbjct: 321 LDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGALWARTGG 367
>gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens]
Length = 504
Score = 122 bits (306), Expect = 8e-28
Identities = 137/435 (31%), Positives = 177/435 (40%), Gaps = 54/435 (12%)
Query: 17 PLRAAGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAAL 76
P CP C C + + C L L+ VP +P T L L N + RL PG LAPL L
Sbjct: 28 PRALHNCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQL 87
Query: 77 RRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLAR 136
R L+L +N L AL G F L L L+SN LR L GL L L L N+L
Sbjct: 88 RALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVH 147
Query: 137 LLDFTFLHLPRLQELHLQENSIELLEDQALAGLSS--LALLDLSRNQLGTISREALQPLA 194
L + F L L L+L N + L GLS+ L LDLS N+LG IS L L
Sbjct: 148 LDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALP 207
Query: 195 SL--QVLRLTENPWRCDCAL-HWLGAWIKEGGQRLLTSRD--RKIMCAEPPRLALQSLLD 249
+ L L NP CDC L H L W + G L RD R+ +C ++ +
Sbjct: 208 AFLKNGLYLHNNPLPCDCRLYHLLQRWHQRG---LSAVRDFAREYVCL-AFKVPASRVRF 263
Query: 250 VSHSSLICIPPSVHVQPLE-----LTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRP 304
HS + S LE L A +G LR+ C S P + W P++
Sbjct: 264 FQHSRVFENCSSAPALGLERPEEHLYALVGRSLRLYCNTS-VPAMRIAW---VSPQQELL 319
Query: 305 RAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNA 364
RA +G + L G L + N+ HAG + C A+ RL N
Sbjct: 320 RAPGSRDGSIAVL--------ADGSLAIGNVQEQHAGLFVCLATGP--------RLHHNQ 363
Query: 365 SRQQPQQPAQPPPPAARPAGSEPRPEAGSMAFRALGVATQTAIAAAIALLALTALLLVAM 424
+ + P P PEA + F T + A+ L+ L L L A
Sbjct: 364 THEYNVSVHFP----------RPEPEAFNTGF-------TTLLGCAVGLV-LVLLYLFAP 405
Query: 425 ICRRRRRRKKARGPP 439
CR RR + R P
Sbjct: 406 PCRCCRRACRCRRWP 420
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 122 bits (306), Expect = 8e-28
Identities = 79/247 (31%), Positives = 115/247 (46%), Gaps = 5/247 (2%)
Query: 11 LLLLLLPLRAAGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGAL 70
+L +L + CPA C C +TV+C L LR VP IP T+ L L NNI R+
Sbjct: 16 VLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDF 75
Query: 71 APLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLA 130
A L LR L L N + +E GAF+ L L L N L+ F+G A+L L L+
Sbjct: 76 AGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLS 135
Query: 131 GNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREAL 190
NQ+ + F ++ L L N I +ED A L L +L L+ N + +S +
Sbjct: 136 ENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASF 195
Query: 191 QPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDV 250
+ L+ RL N CDC L WL W+++ + L ++ C P L ++ +V
Sbjct: 196 NHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQ-----CMGPSHLRGHNVAEV 250
Query: 251 SHSSLIC 257
+C
Sbjct: 251 QKREFVC 257
Score = 117 bits (292), Expect = 3e-26
Identities = 77/236 (32%), Positives = 111/236 (47%), Gaps = 30/236 (12%)
Query: 23 CPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEP-GALAPLAALRRLYL 81
CP CRC TV+C +L +P IP T L L +N LE G L LR++
Sbjct: 506 CPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINF 565
Query: 82 HNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFT 141
NN + +E GAF + E+ LTSNRL ++ F GL L+ L L N++ + + +
Sbjct: 566 SNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDS 625
Query: 142 FLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRL 201
F+ GLSS+ LL L NQ+ T++ A L SL L L
Sbjct: 626 FI------------------------GLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNL 661
Query: 202 TENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLIC 257
NP+ C+C L WLG W+++ +R++T R C +P L + DV+ C
Sbjct: 662 LANPFNCNCYLAWLGEWLRK--KRIVTGNPR---CQKPYFLKEIPIQDVAIQDFTC 712
Score = 107 bits (268), Expect = 2e-23
Identities = 73/235 (31%), Positives = 101/235 (42%), Gaps = 29/235 (12%)
Query: 23 CPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLH 82
CPAAC C + V+C L +P +P + L+ N I + PGA +P LRR+ L
Sbjct: 273 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 332
Query: 83 NNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTF 142
NN + L AF+ GL L L L GN++ L F
Sbjct: 333 NNQISELAPDAFQ------------------------GLRSLNSLVLYGNKITELPKSLF 368
Query: 143 LHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLT 202
L LQ L L N I L A L +L LL L N+L TI++ PL ++Q + L
Sbjct: 369 EGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLA 428
Query: 203 ENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLIC 257
+NP+ CDC L WL ++ +R C P RLA + + + C
Sbjct: 429 QNPFICDCHLKWLADYLHTNPIETSGAR-----CTSPRRLANKRIGQIKSKKFRC 478
Score = 74.3 bits (181), Expect = 2e-13
Identities = 65/238 (27%), Positives = 90/238 (37%), Gaps = 54/238 (22%)
Query: 23 CPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLH 82
CP C C V C L+V+P GIP L+L D N L P L+ Y H
Sbjct: 727 CPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYL-DGNQFTLVPKELSN-------YKH 778
Query: 83 NNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTF 142
L + L++NR+ L + +F + QL L L+ N+L + TF
Sbjct: 779 -----------------LTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTF 821
Query: 143 LHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLT 202
GL SL LL L N + + A L++L L +
Sbjct: 822 ------------------------DGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIG 857
Query: 203 ENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPP 260
NP CDC + WL W+K + +R CA P +A + LL C P
Sbjct: 858 ANPLYCDCNMQWLSDWVKSEYKEPGIAR-----CAGPGEMADKLLLTTPSKKFTCQGP 910
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 119 bits (297), Expect = 9e-27
Identities = 82/196 (41%), Positives = 104/196 (53%), Gaps = 3/196 (1%)
Query: 11 LLLLLLPLRAAG-CPAACRCYSA--TVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEP 67
L LLLLP + G CPA C C S V CG +L VP G+P T+ L L N + L+
Sbjct: 18 LFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQ 77
Query: 68 GALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVL 127
G L+ L+ L+ L L N L LE GAF LL L L NRLR + G F GL+ L +L
Sbjct: 78 GMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLL 137
Query: 128 YLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISR 187
L NQ+ LD F L LQ+L + +N + + A AGL+ L+ L L R L T+
Sbjct: 138 DLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPG 197
Query: 188 EALQPLASLQVLRLTE 203
AL L +L LRL E
Sbjct: 198 LALARLPALVALRLRE 213
Score = 93.2 bits (230), Expect = 5e-19
Identities = 89/292 (30%), Positives = 125/292 (42%), Gaps = 12/292 (4%)
Query: 50 PGTQTLFLQDNNIARLEPGALAPLAALRRLYLHN-NSLRALEAGAFRAQPRLLELALTSN 108
P L L++ +I RL GAL L L+ L +H SL AL+ G+ L LA+T
Sbjct: 204 PALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGL-NLSSLAITRC 262
Query: 109 RLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAG 168
L + A L+ LRVL L+ N ++ + L RLQEL L + + A G
Sbjct: 263 NLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHG 322
Query: 169 LSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLT 228
L++ LLD++ N L T+ A L LRL+ NP CDC L WL +R L
Sbjct: 323 LTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRL-----RRHLD 377
Query: 229 SRDRKIMCAEPPRLALQSLLDVSH----SSLICIPPSVHVQ-PLELTANLGEDLRVACQA 283
CA P + +SL + S C P + P + A G +C
Sbjct: 378 FGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSG 437
Query: 284 SGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNI 335
G P P V+W + GR LE G L + D G+ + +SN+
Sbjct: 438 DGDPAPTVSWMRPHGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNV 489
Score = 35.0 bits (79), Expect = 0.16
Identities = 25/57 (43%), Positives = 29/57 (50%)
Query: 151 LHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWR 207
L L N + L+ L+ LS L LDLS NQL T+ A L SL LRL N R
Sbjct: 65 LDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLR 121
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 118 bits (296), Expect = 1e-26
Identities = 110/420 (26%), Positives = 156/420 (37%), Gaps = 93/420 (22%)
Query: 20 AAGCPAACRC--YSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALR 77
A CP AC C ++ V C L VP IP T+ L LQ+N I + L L
Sbjct: 54 ATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLE 113
Query: 78 RLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARL 137
L L N +R +E GAF P L L L NRL + + AF L++LR L+L N + +
Sbjct: 114 ILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESI 173
Query: 138 LDFTFLHLP-----------------------------------------------RLQE 150
+ F +P RL+E
Sbjct: 174 PSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEE 233
Query: 151 LHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTEN------ 204
L L N ++L+ + GL+SL L L Q+ TI R A L SL+ L L+ N
Sbjct: 234 LELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLP 293
Query: 205 ------------------PWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQS 246
PW C+C + WL W+KE T R C P L +
Sbjct: 294 HDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCAR---CHAPAGLKGRY 350
Query: 247 LLDVSHSSLICIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRA 306
+ ++ S C P + P +L G + C+ +G V W
Sbjct: 351 IGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCR-TGTSMTSVNW------------- 396
Query: 307 QAQLEGGLLGLGGHSA--SDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNA 364
G L+ G + S G L +N+T+ G+Y C +N+ G L V+A
Sbjct: 397 -LTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSA 455
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 118 bits (296), Expect = 1e-26
Identities = 114/444 (25%), Positives = 170/444 (38%), Gaps = 102/444 (22%)
Query: 10 PLLLLLLPL---------RAAGCPAACRCYS--ATVECGALRLRVVPLGIPPGTQ----- 53
PLL++LL L RA CP+ C C + + V C LR VP GI T+
Sbjct: 25 PLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLH 84
Query: 54 -------------------------------------------TLFLQDNNIARLEPGAL 70
TL L DN + + GA
Sbjct: 85 ENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAF 144
Query: 71 APLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTS-NRLRGLRSGAFVGLAQLRVLYL 129
L+ L+ L+L NN + ++ + AF P L L L RL + GAF GL+ LR L L
Sbjct: 145 VYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNL 204
Query: 130 A----------------------GNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALA 167
A GN L+ + +F L LQ+L + ++ I+++E A
Sbjct: 205 AMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFD 264
Query: 168 GLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLL 227
L SL ++L+ N L + + PL L+ + L NPW C+C + WL WIK+
Sbjct: 265 NLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNT 324
Query: 228 TSRDRKIMCAEPPRLALQSLLDVSHSSLICIPPSVHVQPLELTANLGEDLRVACQASGYP 287
R C PP L + + ++ + C P + P +L G + C+AS
Sbjct: 325 ACCAR---CNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRAS-TS 380
Query: 288 QPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGHSA--SDTGSGMLFLSNITLAHAGKYEC 345
V+W G ++ G + + G L +N+T+ G Y C
Sbjct: 381 LTSVSW--------------ITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTC 426
Query: 346 EASNAGGAARVPFRLLVNASRQQP 369
SN+ G L V A+ P
Sbjct: 427 MVSNSVGNTTASATLNVTAATTTP 450
>gi|194306623 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 117 bits (294), Expect = 2e-26
Identities = 116/418 (27%), Positives = 156/418 (37%), Gaps = 75/418 (17%)
Query: 20 AAGCPAACRCYSATV----ECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAA 75
A CP C C +C LR VP G+P TL L N I L GA A +
Sbjct: 17 AGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQ 76
Query: 76 LRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLA 135
+ L+L +N +R +E GA L+QL+ L L+ N ++
Sbjct: 77 VTSLWLAHNEVRTVEP------------------------GALAVLSQLKNLDLSHNFIS 112
Query: 136 RLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLAS 195
+L LQ L + N + L AL L L L ++ N+L T++ L++
Sbjct: 113 SFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSA 172
Query: 196 LQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSL 255
L L+L NP+ C C L WL AW R+ I CA PP ALQ + +L
Sbjct: 173 LSHLQLYHNPFHCGCGLVWLQAW--AASTRVSLPEPDSIACASPP--ALQGVPVYRLPAL 228
Query: 256 ICIPPSVHVQ---PLELTA---NLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQ 309
C PPSVH+ PLE G + C A G+P P + W ++ P
Sbjct: 229 PCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQW-QLQIPGGTVVLEPPV 287
Query: 310 LEGGLLGLGGHSASDTGSG-------------------------MLFLSN-------ITL 337
L G G+G G G L L+N ++
Sbjct: 288 LSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSA 347
Query: 338 AHAGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPPPAARPAGSEPRPEAGSMA 395
AG Y C A N GA R+ V A+ P P P G P E S A
Sbjct: 348 KEAGVYTCRAHNELGANSTSIRVAVAAT----GPPKHAPGAGGEPDGQAPTSERKSTA 401
>gi|194306621 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 117 bits (294), Expect = 2e-26
Identities = 116/418 (27%), Positives = 156/418 (37%), Gaps = 75/418 (17%)
Query: 20 AAGCPAACRCYSATV----ECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAA 75
A CP C C +C LR VP G+P TL L N I L GA A +
Sbjct: 17 AGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQ 76
Query: 76 LRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLA 135
+ L+L +N +R +E GA L+QL+ L L+ N ++
Sbjct: 77 VTSLWLAHNEVRTVEP------------------------GALAVLSQLKNLDLSHNFIS 112
Query: 136 RLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLAS 195
+L LQ L + N + L AL L L L ++ N+L T++ L++
Sbjct: 113 SFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSA 172
Query: 196 LQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSL 255
L L+L NP+ C C L WL AW R+ I CA PP ALQ + +L
Sbjct: 173 LSHLQLYHNPFHCGCGLVWLQAW--AASTRVSLPEPDSIACASPP--ALQGVPVYRLPAL 228
Query: 256 ICIPPSVHVQ---PLELTA---NLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQ 309
C PPSVH+ PLE G + C A G+P P + W ++ P
Sbjct: 229 PCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQW-QLQIPGGTVVLEPPV 287
Query: 310 LEGGLLGLGGHSASDTGSG-------------------------MLFLSN-------ITL 337
L G G+G G G L L+N ++
Sbjct: 288 LSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSA 347
Query: 338 AHAGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPPPAARPAGSEPRPEAGSMA 395
AG Y C A N GA R+ V A+ P P P G P E S A
Sbjct: 348 KEAGVYTCRAHNELGANSTSIRVAVAAT----GPPKHAPGAGGEPDGQAPTSERKSTA 401
>gi|39930401 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 117 bits (294), Expect = 2e-26
Identities = 116/418 (27%), Positives = 156/418 (37%), Gaps = 75/418 (17%)
Query: 20 AAGCPAACRCYSATV----ECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAA 75
A CP C C +C LR VP G+P TL L N I L GA A +
Sbjct: 17 AGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQ 76
Query: 76 LRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLA 135
+ L+L +N +R +E GA L+QL+ L L+ N ++
Sbjct: 77 VTSLWLAHNEVRTVEP------------------------GALAVLSQLKNLDLSHNFIS 112
Query: 136 RLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLAS 195
+L LQ L + N + L AL L L L ++ N+L T++ L++
Sbjct: 113 SFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSA 172
Query: 196 LQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSL 255
L L+L NP+ C C L WL AW R+ I CA PP ALQ + +L
Sbjct: 173 LSHLQLYHNPFHCGCGLVWLQAW--AASTRVSLPEPDSIACASPP--ALQGVPVYRLPAL 228
Query: 256 ICIPPSVHVQ---PLELTA---NLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQ 309
C PPSVH+ PLE G + C A G+P P + W ++ P
Sbjct: 229 PCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQW-QLQIPGGTVVLEPPV 287
Query: 310 LEGGLLGLGGHSASDTGSG-------------------------MLFLSN-------ITL 337
L G G+G G G L L+N ++
Sbjct: 288 LSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSA 347
Query: 338 AHAGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPPPAARPAGSEPRPEAGSMA 395
AG Y C A N GA R+ V A+ P P P G P E S A
Sbjct: 348 KEAGVYTCRAHNELGANSTSIRVAVAAT----GPPKHAPGAGGEPDGQAPTSERKSTA 401
>gi|194306618 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 117 bits (294), Expect = 2e-26
Identities = 116/418 (27%), Positives = 156/418 (37%), Gaps = 75/418 (17%)
Query: 20 AAGCPAACRCYSATV----ECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAA 75
A CP C C +C LR VP G+P TL L N I L GA A +
Sbjct: 17 AGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQ 76
Query: 76 LRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLA 135
+ L+L +N +R +E GA L+QL+ L L+ N ++
Sbjct: 77 VTSLWLAHNEVRTVEP------------------------GALAVLSQLKNLDLSHNFIS 112
Query: 136 RLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLAS 195
+L LQ L + N + L AL L L L ++ N+L T++ L++
Sbjct: 113 SFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSA 172
Query: 196 LQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSL 255
L L+L NP+ C C L WL AW R+ I CA PP ALQ + +L
Sbjct: 173 LSHLQLYHNPFHCGCGLVWLQAW--AASTRVSLPEPDSIACASPP--ALQGVPVYRLPAL 228
Query: 256 ICIPPSVHVQ---PLELTA---NLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQ 309
C PPSVH+ PLE G + C A G+P P + W ++ P
Sbjct: 229 PCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQW-QLQIPGGTVVLEPPV 287
Query: 310 LEGGLLGLGGHSASDTGSG-------------------------MLFLSN-------ITL 337
L G G+G G G L L+N ++
Sbjct: 288 LSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSA 347
Query: 338 AHAGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPPPAARPAGSEPRPEAGSMA 395
AG Y C A N GA R+ V A+ P P P G P E S A
Sbjct: 348 KEAGVYTCRAHNELGANSTSIRVAVAAT----GPPKHAPGAGGEPDGQAPTSERKSTA 401
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 117 bits (293), Expect = 3e-26
Identities = 100/353 (28%), Positives = 141/353 (39%), Gaps = 46/353 (13%)
Query: 23 CPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLH 82
CP+ C C+ +TV C L L +P +P T L L+ N I + A L L L L+
Sbjct: 24 CPSRCLCFKSTVRCMHLMLDHIPQ-VPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLN 82
Query: 83 NNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTF 142
NN +R + AF LL L L N + L F GL L LY+ NQL L TF
Sbjct: 83 NNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETF 142
Query: 143 LHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLT 202
L RL+ L L N LS+ G+ S L SL+ LRL
Sbjct: 143 GDLLRLERLFLHNNK-------------------LSKIPAGSFSN-----LDSLKRLRLD 178
Query: 203 ENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPPSV 262
N CDC L WLG ++ Q T C P RL +++ V+ C P +
Sbjct: 179 SNALVCDCDLMWLGELLQGFAQHGHT--QAAATCEYPRRLHGRAVASVTVEEFNCQSPRI 236
Query: 263 HVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGHSA 322
+P ++ G + C+A G P+P + W + + +
Sbjct: 237 TFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNV------------ 284
Query: 323 SDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQP 375
G L + N + G Y+C A N+ G A+ +L +S PA+P
Sbjct: 285 --FDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSS-----LPAKP 330
Score = 52.8 bits (125), Expect = 8e-07
Identities = 33/108 (30%), Positives = 50/108 (46%), Gaps = 17/108 (15%)
Query: 260 PSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGG 319
PS +QP + +G + C A+G+P PL+TW + + G L L G
Sbjct: 330 PSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTR---------------DNG-LELDG 373
Query: 320 HSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNASRQ 367
T SG L+L NIT G++ C A+N+ G + ++V A Q
Sbjct: 374 SRHVATSSG-LYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQ 420
Score = 43.5 bits (101), Expect = 5e-04
Identities = 28/99 (28%), Positives = 43/99 (43%), Gaps = 16/99 (16%)
Query: 266 PLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGHSASDT 325
P + + +G+++ ++C A G PQP++TW K EG + G D
Sbjct: 517 PQDTSVEVGKNINISCHAQGEPQPIITWNK---------------EGVQITESGKFHVD- 560
Query: 326 GSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNA 364
G L + + G+YEC A N+ G A L V A
Sbjct: 561 DEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTA 599
Score = 39.3 bits (90), Expect = 0.009
Identities = 40/168 (23%), Positives = 58/168 (34%), Gaps = 38/168 (22%)
Query: 213 HWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLIC--------------- 257
H L W ++ G L SR A L LQ++ H C
Sbjct: 358 HPLITWTRDNGLELDGSRH----VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANI 413
Query: 258 ---IPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGL 314
PP V P + + C+A G P P++ W K GG
Sbjct: 414 IVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKT---------------GGQ 458
Query: 315 LGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLV 362
L + G + SG L + G+YEC+A ++ G +V +L V
Sbjct: 459 LPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV 505
>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
Length = 441
Score = 117 bits (293), Expect = 3e-26
Identities = 90/271 (33%), Positives = 112/271 (41%), Gaps = 54/271 (19%)
Query: 3 LRAPALLPLLLLL----LPLRAAGCPAACRCYSA--TVECGALRLRVVPLGIPPGTQTLF 56
LR + LLLLL LPL GCP C CY A TV C A +P GIP ++ +F
Sbjct: 2 LRKGCCVELLLLLVAAELPL-GGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVF 60
Query: 57 LQDNNIARLEPGALAP-------------------------------------------- 72
LQ+N I L+PG +P
Sbjct: 61 LQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPET 120
Query: 73 ---LAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYL 129
L L LYL+ L AL AG F L L L N + L+ FV L L L+L
Sbjct: 121 FQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFL 180
Query: 130 AGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREA 189
GN+L L TF L L L L EN ++ + +A L L L L N L + E
Sbjct: 181 HGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGEC 240
Query: 190 LQPLASLQVLRLTENPWRCDCALHWLGAWIK 220
L PL +L+ LRL NPW C C L W++
Sbjct: 241 LAPLGALEFLRLNGNPWDCGCRARSLWEWLQ 271
>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
Length = 334
Score = 116 bits (291), Expect = 4e-26
Identities = 95/288 (32%), Positives = 119/288 (41%), Gaps = 43/288 (14%)
Query: 4 RAPALLPLLLLLLP----------------LRAAGCPAACRCY-SATVECGALRLRVVPL 46
R LL LLLLL P L A CP C C C AL L VP
Sbjct: 8 RPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPP 67
Query: 47 GIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALT 106
G+ + L L N + L PGA A AL+RL L N L ++ AF L L L+
Sbjct: 68 GLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLS 127
Query: 107 SNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQAL 166
+N+L L G F L LR L LAGN+LARL E AL
Sbjct: 128 ANQLEALAPGTFAPLRALRNLSLAGNRLARL------------------------EPAAL 163
Query: 167 AGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRL 226
L L L L N+L ++ L L +L L L NPW C CAL L AW++ L
Sbjct: 164 GALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRR--HPL 221
Query: 227 LTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPPSVHVQPLELTANLG 274
S ++C P RL L L S ++ + ++ L + LG
Sbjct: 222 PASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLG 269
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 113 bits (283), Expect = 4e-25
Identities = 108/385 (28%), Positives = 160/385 (41%), Gaps = 46/385 (11%)
Query: 53 QTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRG 112
+ L L NN+ + G L L L+ L+L N++ + A+ +L EL LT N L
Sbjct: 266 EILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSR 325
Query: 113 LRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIE-LLED-------- 163
L +F+GL+ L L++ N+++ + D F L L+ L L+ N I +ED
Sbjct: 326 LDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGL 385
Query: 164 ------------------QALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENP 205
+A GL +L LDLS N + ++ A + LQ L L +
Sbjct: 386 DKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSS 445
Query: 206 WRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLIC---IPPSV 262
CDC L WL W+ E + + CA P L +S+ VS +C P +
Sbjct: 446 LLCDCQLKWLPQWVAENNFQSFVNAS----CAHPQLLKGRSIFAVSPDGFVCDDFPKPQI 501
Query: 263 HVQPLELTANLGEDLRVACQASGYPQPLVT--WRKVPQPREGRPRAQAQLEGGLLGLGGH 320
VQP +A G +L C A+ +T W+K E A+ + L GG
Sbjct: 502 TVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKK---DNELLHDAEMENYAHLRAQGGE 558
Query: 321 SASDTGSGMLFLSNITLAHAGKYECEASN-AGGAARVPFRLLVNASRQQPQQPAQPPPPA 379
T +L L + A GKY+C SN G + V +L VN P P
Sbjct: 559 VMEYT--TILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVN---MLPSFTKTPMDLT 613
Query: 380 ARPAGSEPRPEAGSMAFRALGVATQ 404
R AG+ R E ++ A +A Q
Sbjct: 614 IR-AGAMARLECAAVGHPAPQIAWQ 637
Score = 68.9 bits (167), Expect = 1e-11
Identities = 59/228 (25%), Positives = 94/228 (41%), Gaps = 47/228 (20%)
Query: 23 CPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLH 82
CP CRC ++C RL +P +P L L N ++ ++ +++ L +LR + L+
Sbjct: 47 CPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLN 106
Query: 83 NNSLRAL-EAGAFRAQPRLLELA------------------------------------- 104
NN L + G A LL LA
Sbjct: 107 NNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPA 166
Query: 105 -------LTSNRLRGLRSGAFVGLAQ-LRVLYLAGNQLARLLDFTFLHLPRLQELHLQEN 156
L SNR+ + G F LA L VL L N+++ + F LP+LQ L L N
Sbjct: 167 LQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRN 225
Query: 157 SIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTEN 204
I+ ++ GL +L L + RN + + A L+++++L+L N
Sbjct: 226 KIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHN 273
Score = 66.2 bits (160), Expect = 7e-11
Identities = 48/155 (30%), Positives = 72/155 (46%)
Query: 50 PGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNR 109
P Q L L N I ++ L AL+ L + N + L GAF + L L N
Sbjct: 215 PQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNN 274
Query: 110 LRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGL 169
L + G GL L+ L+L+ N + R+ + +L EL L N + L+D + GL
Sbjct: 275 LTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGL 334
Query: 170 SSLALLDLSRNQLGTISREALQPLASLQVLRLTEN 204
S L L + N++ I+ A + L+SL+ L L N
Sbjct: 335 SLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 369
Score = 65.1 bits (157), Expect = 1e-10
Identities = 48/165 (29%), Positives = 75/165 (45%), Gaps = 3/165 (1%)
Query: 55 LFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLR 114
L L N I+ + P + L L+ L L+ N ++ ++ F+ L L + N + L
Sbjct: 197 LKLNRNRISAIPP-KMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 255
Query: 115 SGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLAL 174
GAF GL+ + +L L N L + L LQELHL +N+I + A L+
Sbjct: 256 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 315
Query: 175 LDLSRNQLGTISREALQPLASLQVLRLTEN--PWRCDCALHWLGA 217
LDL+ N L + + L+ L L + N + DCA L +
Sbjct: 316 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS 360
Score = 53.1 bits (126), Expect = 6e-07
Identities = 79/345 (22%), Positives = 134/345 (38%), Gaps = 66/345 (19%)
Query: 53 QTLFLQDNNIA-RLEP--GALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNR 109
+TL L++N I+ +E GA + L LRRL L N +R++ AF L L L+ N
Sbjct: 362 KTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNA 421
Query: 110 LRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPR-LQELHLQEN-SIELLEDQALA 167
+ L+ AF + +L+ L+L N + L D LP+ + E + Q + Q L
Sbjct: 422 IMSLQGNAFSQMKKLQQLHL--NTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLK 479
Query: 168 GLSSLALL-------DLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIK 220
G S A+ D + Q+ T+ E + + + D + + AW K
Sbjct: 480 GRSIFAVSPDGFVCDDFPKPQI-TVQPETQSAIKGSNLSFICSAASSSDSPMTF--AWKK 536
Query: 221 E------------------GGQ-----RLLTSRDRKIMCAEPPRLALQSLLDVSHSS--- 254
+ GG+ +L R+ + + + + S+S
Sbjct: 537 DNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAK 596
Query: 255 -LICIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRK-----VPQPREGRPRAQA 308
+ + PS P++LT G R+ C A G+P P + W+K P RE R
Sbjct: 597 LTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMP 656
Query: 309 QLEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGA 353
+ + F+ ++ + G Y C A N+ G+
Sbjct: 657 E-----------------DDVFFIVDVKIEDIGVYSCTAQNSAGS 684
Score = 43.5 bits (101), Expect = 5e-04
Identities = 56/236 (23%), Positives = 86/236 (36%), Gaps = 51/236 (21%)
Query: 217 AWIKEGGQRLLTSRDRKIMCAEPPRL-----------------ALQSLLDVSHSSLICI- 258
AW K+GG +R+R++ + A S +S ++ + +
Sbjct: 635 AWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVL 694
Query: 259 -PPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGL 317
PS L+ T GE + C A G P P + W K P L +
Sbjct: 695 ETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSP---------------LVV 739
Query: 318 GGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPP 377
G+ +L + + ++ AGKY CE SN G R RL V P P
Sbjct: 740 TERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV-----------IPTP 788
Query: 378 PAARPAGSEPRPEAGSMAFRALGVATQTAIAAAIALLALTALLLVAMICRRRRRRK 433
P + P + A +GV I A + + T+L+ V +I RRR +
Sbjct: 789 TCDSPQMTAPSLDDDGWA--TVGV----VIIAVVCCVVGTSLVWVVIIYHTRRRNE 838
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 113 bits (283), Expect = 4e-25
Identities = 108/385 (28%), Positives = 160/385 (41%), Gaps = 46/385 (11%)
Query: 53 QTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRG 112
+ L L NN+ + G L L L+ L+L N++ + A+ +L EL LT N L
Sbjct: 206 EILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSR 265
Query: 113 LRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIE-LLED-------- 163
L +F+GL+ L L++ N+++ + D F L L+ L L+ N I +ED
Sbjct: 266 LDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGL 325
Query: 164 ------------------QALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENP 205
+A GL +L LDLS N + ++ A + LQ L L +
Sbjct: 326 DKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSS 385
Query: 206 WRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLIC---IPPSV 262
CDC L WL W+ E + + CA P L +S+ VS +C P +
Sbjct: 386 LLCDCQLKWLPQWVAENNFQSFVNAS----CAHPQLLKGRSIFAVSPDGFVCDDFPKPQI 441
Query: 263 HVQPLELTANLGEDLRVACQASGYPQPLVT--WRKVPQPREGRPRAQAQLEGGLLGLGGH 320
VQP +A G +L C A+ +T W+K E A+ + L GG
Sbjct: 442 TVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKK---DNELLHDAEMENYAHLRAQGGE 498
Query: 321 SASDTGSGMLFLSNITLAHAGKYECEASN-AGGAARVPFRLLVNASRQQPQQPAQPPPPA 379
T +L L + A GKY+C SN G + V +L VN P P
Sbjct: 499 VMEYT--TILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVN---MLPSFTKTPMDLT 553
Query: 380 ARPAGSEPRPEAGSMAFRALGVATQ 404
R AG+ R E ++ A +A Q
Sbjct: 554 IR-AGAMARLECAAVGHPAPQIAWQ 577
Score = 66.2 bits (160), Expect = 7e-11
Identities = 48/155 (30%), Positives = 72/155 (46%)
Query: 50 PGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNR 109
P Q L L N I ++ L AL+ L + N + L GAF + L L N
Sbjct: 155 PQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNN 214
Query: 110 LRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGL 169
L + G GL L+ L+L+ N + R+ + +L EL L N + L+D + GL
Sbjct: 215 LTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGL 274
Query: 170 SSLALLDLSRNQLGTISREALQPLASLQVLRLTEN 204
S L L + N++ I+ A + L+SL+ L L N
Sbjct: 275 SLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 309
Score = 65.1 bits (157), Expect = 1e-10
Identities = 48/165 (29%), Positives = 75/165 (45%), Gaps = 3/165 (1%)
Query: 55 LFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLR 114
L L N I+ + P + L L+ L L+ N ++ ++ F+ L L + N + L
Sbjct: 137 LKLNRNRISAIPP-KMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195
Query: 115 SGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLAL 174
GAF GL+ + +L L N L + L LQELHL +N+I + A L+
Sbjct: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255
Query: 175 LDLSRNQLGTISREALQPLASLQVLRLTEN--PWRCDCALHWLGA 217
LDL+ N L + + L+ L L + N + DCA L +
Sbjct: 256 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS 300
Score = 58.2 bits (139), Expect = 2e-08
Identities = 49/151 (32%), Positives = 76/151 (50%), Gaps = 4/151 (2%)
Query: 55 LFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLR 114
L L N I + P L +L L L +N++ L+ AF A +L L L SNR+ +
Sbjct: 66 LSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSME 123
Query: 115 SGAFVGLAQ-LRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLA 173
G F LA L VL L N+++ + F LP+LQ L L N I+ ++ GL +L
Sbjct: 124 PGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALK 182
Query: 174 LLDLSRNQLGTISREALQPLASLQVLRLTEN 204
L + RN + + A L+++++L+L N
Sbjct: 183 SLKMQRNGVTKLMDGAFWGLSNMEILQLDHN 213
Score = 53.1 bits (126), Expect = 6e-07
Identities = 79/345 (22%), Positives = 134/345 (38%), Gaps = 66/345 (19%)
Query: 53 QTLFLQDNNIA-RLEP--GALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNR 109
+TL L++N I+ +E GA + L LRRL L N +R++ AF L L L+ N
Sbjct: 302 KTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNA 361
Query: 110 LRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPR-LQELHLQEN-SIELLEDQALA 167
+ L+ AF + +L+ L+L N + L D LP+ + E + Q + Q L
Sbjct: 362 IMSLQGNAFSQMKKLQQLHL--NTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLK 419
Query: 168 GLSSLALL-------DLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIK 220
G S A+ D + Q+ T+ E + + + D + + AW K
Sbjct: 420 GRSIFAVSPDGFVCDDFPKPQI-TVQPETQSAIKGSNLSFICSAASSSDSPMTF--AWKK 476
Query: 221 E------------------GGQ-----RLLTSRDRKIMCAEPPRLALQSLLDVSHSS--- 254
+ GG+ +L R+ + + + + S+S
Sbjct: 477 DNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAK 536
Query: 255 -LICIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRK-----VPQPREGRPRAQA 308
+ + PS P++LT G R+ C A G+P P + W+K P RE R
Sbjct: 537 LTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMP 596
Query: 309 QLEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGA 353
+ + F+ ++ + G Y C A N+ G+
Sbjct: 597 E-----------------DDVFFIVDVKIEDIGVYSCTAQNSAGS 624
Score = 43.5 bits (101), Expect = 5e-04
Identities = 56/236 (23%), Positives = 86/236 (36%), Gaps = 51/236 (21%)
Query: 217 AWIKEGGQRLLTSRDRKIMCAEPPRL-----------------ALQSLLDVSHSSLICI- 258
AW K+GG +R+R++ + A S +S ++ + +
Sbjct: 575 AWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVL 634
Query: 259 -PPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGL 317
PS L+ T GE + C A G P P + W K P L +
Sbjct: 635 ETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSP---------------LVV 679
Query: 318 GGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPP 377
G+ +L + + ++ AGKY CE SN G R RL V P P
Sbjct: 680 TERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV-----------IPTP 728
Query: 378 PAARPAGSEPRPEAGSMAFRALGVATQTAIAAAIALLALTALLLVAMICRRRRRRK 433
P + P + A +GV I A + + T+L+ V +I RRR +
Sbjct: 729 TCDSPQMTAPSLDDDGWA--TVGV----VIIAVVCCVVGTSLVWVVIIYHTRRRNE 778
Score = 35.0 bits (79), Expect = 0.16
Identities = 38/137 (27%), Positives = 62/137 (45%), Gaps = 4/137 (2%)
Query: 69 ALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLY 128
+L L + R L +N L ++A + L E+ L +N L + + V A + +L
Sbjct: 9 SLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLS 67
Query: 129 LAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISRE 188
LAGN++ +L L+ L L N+I E Q L L L+ N++ ++
Sbjct: 68 LAGNRIVEILPEHLKEFQSLETLDLSSNNIS--ELQTAFPALQLKYLYLNSNRVTSMEPG 125
Query: 189 ALQPLA-SLQVLRLTEN 204
LA +L VL+L N
Sbjct: 126 YFDNLANTLLVLKLNRN 142
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 113 bits (283), Expect = 4e-25
Identities = 108/416 (25%), Positives = 162/416 (38%), Gaps = 90/416 (21%)
Query: 23 CPAACRCYS--ATVECGALRLRVVPLGIPPGTQTLFLQDNNIA----------------- 63
CP+ C C + + V C L VP GIP T+ L L +NNI
Sbjct: 46 CPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQ 105
Query: 64 -------RLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRS- 115
++E GA LA+L L L +N L + +GAF +L EL L +N + + S
Sbjct: 106 LGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSY 165
Query: 116 ------------------------GAFVGLAQLRVLYL---------------------- 129
GAF GL L+ L L
Sbjct: 166 AFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEM 225
Query: 130 AGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREA 189
+GN + +F L L++L + + + L+E A GL+SL L+L+ N L ++ +
Sbjct: 226 SGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDL 285
Query: 190 LQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLD 249
PL L L L NPW CDC + WL W++E T R C P + + L++
Sbjct: 286 FTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGR---CHAPMHMRGRYLVE 342
Query: 250 VSHSSLICIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQ 309
V +S C P + P +L + G + C+ P V W +P G + A
Sbjct: 343 VDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTP--PMSSVKW-LLP---NGTVLSHAS 396
Query: 310 LEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNAS 365
+ S G L S++ L+ G Y C +N G + L V+ +
Sbjct: 397 RHPRI--------SVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTA 444
>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
sapiens]
Length = 345
Score = 112 bits (281), Expect = 6e-25
Identities = 97/310 (31%), Positives = 139/310 (44%), Gaps = 54/310 (17%)
Query: 3 LRAPALLPLLLLLLPLRAAGCPAACRCYSAT--VECGALRLRVVPLGIPPGTQTLFLQDN 60
++ LL +++L CP C C S+T V+C L +P +PP T+TL LQDN
Sbjct: 1 MKGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDN 60
Query: 61 NIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVG 120
I L A AFR+ P L+ L L++N L L GAF G
Sbjct: 61 QIHHLP------------------------AFAFRSVPWLMTLNLSNNSLSNLAPGAFHG 96
Query: 121 LAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRN 180
L L+VL L N L L F LP+L+EL L N+I L +L +L + +N
Sbjct: 97 LQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQN 156
Query: 181 QLGTISREALQPLASLQVLRLTENPWRCDCAL----HWLGAWIKEGGQRLLTSRDRKIMC 236
QL + R L+ + S+++L L +N W+C+C L WL ++ +GG LT I+C
Sbjct: 157 QLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGG---LTD---GIIC 210
Query: 237 AEPPRLALQSLLDVSH--------------SSLICIPPSVH---VQPLELTANLGEDLRV 279
P + LL + H SS P S H ++P E N GE +
Sbjct: 211 ESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSAHGVVLRPPE-NHNAGERELL 269
Query: 280 ACQASGYPQP 289
C+ P+P
Sbjct: 270 ECELKPKPRP 279
>gi|88702793 slit-like 2 [Homo sapiens]
Length = 673
Score = 111 bits (278), Expect = 1e-24
Identities = 79/203 (38%), Positives = 106/203 (52%), Gaps = 6/203 (2%)
Query: 1 MALRAPALLPLLLLL-LPLRAAGCPAACRCYSA-TVECGALRLRVVPLGIPPGTQTLFLQ 58
M R P LLPLLLLL L GCP+ C+C TV C A + VP +PP T L++
Sbjct: 1 MCSRVPLLLPLLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVF 60
Query: 59 DNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAF 118
+N I L+ G+ A L L+ L L N + +L +G F+ L L LT+NRL + + F
Sbjct: 61 ENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETF 120
Query: 119 VGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLS 178
GL +L LYL N++ + F L RL EL LQ+N + L L L LLDLS
Sbjct: 121 RGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLS 177
Query: 179 RNQLGTISREALQPLASLQVLRL 201
N L + L A+++ LRL
Sbjct: 178 HNSLLALEPGILD-TANVEALRL 199
Score = 33.5 bits (75), Expect = 0.48
Identities = 27/69 (39%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Query: 42 RVVPL--GIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPR 99
RV P+ G+ T+ + IA+L P LA LAAL+ L + N SL+AL PR
Sbjct: 230 RVPPVIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPR 289
Query: 100 LLELALTSN 108
L LA N
Sbjct: 290 LRLLAAARN 298
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 111 bits (277), Expect = 2e-24
Identities = 90/313 (28%), Positives = 143/313 (45%), Gaps = 29/313 (9%)
Query: 55 LFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLR 114
L L +N+IAR+ + L L L N+L L+ + L L L+ N + +
Sbjct: 288 LHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIA 347
Query: 115 SGAFVGLAQLRVLYLAGNQLARLLDFT---FLHLPRLQELHLQENSIELLEDQALAGLSS 171
GAF GL LRVL L N+++ ++ T F L L +L L N I+ + +A +GL
Sbjct: 348 EGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEG 407
Query: 172 LALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAW-IKEGGQRLLTSR 230
L L+L N + ++ +A + +L+ L ++ + + CDC L WL W I Q +T+
Sbjct: 408 LEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTA- 466
Query: 231 DRKIMCAEPPRLALQSLLDVSHSSLIC---IPPSVHVQPLELTANLGEDLRVACQASGYP 287
CA P L QS+ V S +C + P + QP A +G+D+R C A+
Sbjct: 467 ----TCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSS 522
Query: 288 QPLVT--WRKVPQPREGRPRAQAQLEGGLLGLGGHSASDTGSGM-----LFLSNITLAHA 340
+T W+K + A +E + H + G M L L +T H
Sbjct: 523 SSPMTFAWKK-----DNEVLTNADMENFV-----HVHAQDGEVMEYTTILHLRQVTFGHE 572
Query: 341 GKYECEASNAGGA 353
G+Y+C +N G+
Sbjct: 573 GRYQCVITNHFGS 585
Score = 97.1 bits (240), Expect = 3e-20
Identities = 77/234 (32%), Positives = 111/234 (47%), Gaps = 35/234 (14%)
Query: 4 RAPALLPLLLLLLPLR----AAG----CPAACRCYSATVECGALRLRVVPLGIPPGTQTL 55
R+P LL L LLLL L AAG C AAC C +++CG L +P +P T++L
Sbjct: 14 RSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSL 73
Query: 56 FLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEA-GAFRAQPRLLELALTSNRLRGLR 114
L N ++ ++P L L+ +YL+NN L A+ + GA A ++ L L N++R +
Sbjct: 74 NLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGA--ASSHVVSLFLQHNKIRSVE 131
Query: 115 SGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLS---- 170
L VL L+ N + + + F H P ++EL+L N I LE A GLS
Sbjct: 132 GSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLL 191
Query: 171 --------------------SLALLDLSRNQLGTISREALQPLASLQVLRLTEN 204
L LDL+RN++ I Q L SL+VL+L N
Sbjct: 192 TLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRN 245
Score = 75.9 bits (185), Expect = 8e-14
Identities = 54/155 (34%), Positives = 80/155 (51%)
Query: 50 PGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNR 109
P L L N I +E L +L L L N++ L GAF ++ L L N
Sbjct: 211 PRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNS 270
Query: 110 LRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGL 169
L + SG+ GL L L+L+ N +AR+ + +L EL L N++ L++++LA L
Sbjct: 271 LVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAEL 330
Query: 170 SSLALLDLSRNQLGTISREALQPLASLQVLRLTEN 204
SSL++L LS N + I+ A + L SL+VL L N
Sbjct: 331 SSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHN 365
Score = 75.5 bits (184), Expect = 1e-13
Identities = 59/172 (34%), Positives = 82/172 (47%), Gaps = 7/172 (4%)
Query: 33 TVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAG 92
T+E GA G+ TL L N I +L P L L +L L+ N +R +E
Sbjct: 177 TLELGAFD------GLSRSLLTLRLSKNRITQL-PVRAFKLPRLTQLDLNRNRIRLIEGL 229
Query: 93 AFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELH 152
F+ L L L N + L GAF GL+++ VL+L N L + + L L +LH
Sbjct: 230 TFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLH 289
Query: 153 LQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTEN 204
L NSI + + + L L LS N L + E+L L+SL VLRL+ N
Sbjct: 290 LSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHN 341
Score = 45.4 bits (106), Expect = 1e-04
Identities = 39/165 (23%), Positives = 66/165 (40%), Gaps = 34/165 (20%)
Query: 217 AWIKEGGQRLLTSRDRKIMCAEPPRL-----------------ALQSLLDVSHSSLICI- 258
AW K+GG +R+R++ + A S +S ++ + +
Sbjct: 631 AWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVL 690
Query: 259 -PPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGL 317
PS+ V + ++GE + + C+A+G P P +TW K +P L L
Sbjct: 691 ETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRP---------------LSL 735
Query: 318 GGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLV 362
+ +L + N+ AG+Y CE SN G R +L V
Sbjct: 736 TERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
Score = 38.9 bits (89), Expect = 0.011
Identities = 24/99 (24%), Positives = 39/99 (39%), Gaps = 22/99 (22%)
Query: 260 PSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRK-----VPQPREGRPRAQAQLEGGL 314
PS P ++T R+ C A+G+P P + W+K P RE R
Sbjct: 599 PSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPD----- 653
Query: 315 LGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGA 353
+ F++++ + AG Y C A N+ G+
Sbjct: 654 ------------DDVFFITDVKIDDAGVYSCTAQNSAGS 680
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 109 bits (272), Expect = 7e-24
Identities = 80/242 (33%), Positives = 110/242 (45%), Gaps = 34/242 (14%)
Query: 47 GIPPGT-------QTLFLQDNNIARLEPGALAPLAALRRLYLHNNS-------------- 85
G+P G Q LFL NNI+ L P + L L RL+L N+
Sbjct: 207 GLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGN 266
Query: 86 ----------LRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLA 135
LR L AG F P L+ L+LT N+L + G F L+ LR L L+ N +
Sbjct: 267 LTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAIT 326
Query: 136 RLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLAS 195
L F L L +L+L N++ L LS L LL LS+NQL T+ +
Sbjct: 327 HLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYN 386
Query: 196 LQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSL 255
L L L NPW+CDC L +L W+++ RLL + + CA P L Q + ++ L
Sbjct: 387 LFNLALHGNPWQCDCHLAYLFNWLQQYTDRLL---NIQTYCAGPAYLKGQVVPALNEKQL 443
Query: 256 IC 257
+C
Sbjct: 444 VC 445
Score = 104 bits (260), Expect = 2e-22
Identities = 68/197 (34%), Positives = 91/197 (46%)
Query: 8 LLPLLLLLLPLRAAGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEP 67
LL LLLL A CP C C+ V C L VPL IPP T+ + + + LE
Sbjct: 7 LLWTSLLLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLET 66
Query: 68 GALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVL 127
A L ++ N L AF PRL +L +T + L + F L L L
Sbjct: 67 RAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKL 126
Query: 128 YLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISR 187
L N L L + F HL L+ LHLQ N ++ L + L+ L L+L++N L +
Sbjct: 127 TLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPE 186
Query: 188 EALQPLASLQVLRLTEN 204
E PL SLQ L+L+ N
Sbjct: 187 ELFHPLTSLQTLKLSNN 203
Score = 65.1 bits (157), Expect = 1e-10
Identities = 52/152 (34%), Positives = 70/152 (46%)
Query: 53 QTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRG 112
+TL L N +A+L PL +L+ L L NN+L L G F L EL L SN +
Sbjct: 172 KTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISE 231
Query: 113 LRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSL 172
L F L L L+L N + L F L L L LQ N + +L A L
Sbjct: 232 LPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCL 291
Query: 173 ALLDLSRNQLGTISREALQPLASLQVLRLTEN 204
L L+ NQL T++ L++L+ L L+ N
Sbjct: 292 VGLSLTHNQLETVAEGTFAHLSNLRSLMLSYN 323
Score = 63.5 bits (153), Expect = 4e-10
Identities = 50/152 (32%), Positives = 64/152 (42%)
Query: 53 QTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRG 112
++L LQ N + L PL L+ L L N L L F L L L++N L G
Sbjct: 148 ESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSG 207
Query: 113 LRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSL 172
L G F L L+ L+L N ++ L F L L+ L LQ N+I L A L +L
Sbjct: 208 LPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNL 267
Query: 173 ALLDLSRNQLGTISREALQPLASLQVLRLTEN 204
L L N L + L L LT N
Sbjct: 268 TFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHN 299
Score = 62.8 bits (151), Expect = 7e-10
Identities = 53/153 (34%), Positives = 65/153 (42%)
Query: 55 LFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLR 114
L L N + L G LAAL L+L N L+AL F+ L L L N L L
Sbjct: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185
Query: 115 SGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLAL 174
F L L+ L L+ N L+ L F L LQEL L N+I L Q + L L
Sbjct: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
Query: 175 LDLSRNQLGTISREALQPLASLQVLRLTENPWR 207
L L RN + + L +L L L N R
Sbjct: 246 LWLQRNAITHLPLSIFASLGNLTFLSLQWNMLR 278
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,538,616
Number of Sequences: 37866
Number of extensions: 1172915
Number of successful extensions: 13652
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 391
Number of HSP's successfully gapped in prelim test: 310
Number of HSP's that attempted gapping in prelim test: 9302
Number of HSP's gapped (non-prelim): 2818
length of query: 513
length of database: 18,247,518
effective HSP length: 107
effective length of query: 406
effective length of database: 14,195,856
effective search space: 5763517536
effective search space used: 5763517536
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.