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Search of human proteins with 226342933
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
(510 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 1023 0.0
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 1010 0.0
gi|226342935 podocan-like 1 isoform 3 [Homo sapiens] 614 e-176
gi|45505137 podocan [Homo sapiens] 456 e-128
gi|225579152 insulin-like growth factor binding protein, acid la... 154 1e-37
gi|4826772 insulin-like growth factor binding protein, acid labi... 154 1e-37
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 138 1e-32
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 138 1e-32
gi|41349454 proline arginine-rich end leucine-rich repeat protei... 138 1e-32
gi|4506041 proline arginine-rich end leucine-rich repeat protein... 138 1e-32
gi|71040111 fibromodulin precursor [Homo sapiens] 137 2e-32
gi|5901992 keratocan [Homo sapiens] 134 2e-31
gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens] 131 2e-30
gi|4505047 lumican precursor [Homo sapiens] 124 3e-28
gi|41350214 asporin [Homo sapiens] 124 3e-28
gi|19743846 decorin isoform a preproprotein [Homo sapiens] 122 6e-28
gi|4503271 decorin isoform a preproprotein [Homo sapiens] 122 6e-28
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 122 6e-28
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 122 6e-28
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 121 1e-27
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho... 120 2e-27
gi|4759146 slit homolog 2 [Homo sapiens] 120 3e-27
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 120 3e-27
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 120 4e-27
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 120 4e-27
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 119 7e-27
gi|4502403 biglycan preproprotein [Homo sapiens] 117 2e-26
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 113 4e-25
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 113 4e-25
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 113 5e-25
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 1023 bits (2645), Expect = 0.0
Identities = 510/510 (100%), Positives = 510/510 (100%)
Query: 1 MGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDG 60
MGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDG
Sbjct: 1 MGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDG 60
Query: 61 LDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFES 120
LDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFES
Sbjct: 61 LDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFES 120
Query: 121 LTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLS 180
LTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLS
Sbjct: 121 LTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLS 180
Query: 181 NAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQL 240
NAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQL
Sbjct: 181 NAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQL 240
Query: 241 RELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQV 300
RELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQV
Sbjct: 241 RELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQV 300
Query: 301 EAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRA 360
EAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRA
Sbjct: 301 EAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRA 360
Query: 361 LVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTR 420
LVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTR
Sbjct: 361 LVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTR 420
Query: 421 LPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQ 480
LPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQ
Sbjct: 421 LPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQ 480
Query: 481 VRHRLVSHTVPRAPPSPCLPCHVPNILVSW 510
VRHRLVSHTVPRAPPSPCLPCHVPNILVSW
Sbjct: 481 VRHRLVSHTVPRAPPSPCLPCHVPNILVSW 510
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 1010 bits (2612), Expect = 0.0
Identities = 504/504 (100%), Positives = 504/504 (100%)
Query: 7 WPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDGLDLRVF 66
WPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDGLDLRVF
Sbjct: 9 WPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDGLDLRVF 68
Query: 67 PDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQH 126
PDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQH
Sbjct: 69 PDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQH 128
Query: 127 LCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPP 186
LCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPP
Sbjct: 129 LCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPP 188
Query: 187 DAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQ 246
DAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQ
Sbjct: 189 DAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQ 248
Query: 247 HNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLH 306
HNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLH
Sbjct: 249 HNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLH 308
Query: 307 GARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHN 366
GARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHN
Sbjct: 309 GARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHN 368
Query: 367 HVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLP 426
HVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLP
Sbjct: 369 HVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLP 428
Query: 427 TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLV 486
TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLV
Sbjct: 429 TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLV 488
Query: 487 SHTVPRAPPSPCLPCHVPNILVSW 510
SHTVPRAPPSPCLPCHVPNILVSW
Sbjct: 489 SHTVPRAPPSPCLPCHVPNILVSW 512
>gi|226342935 podocan-like 1 isoform 3 [Homo sapiens]
Length = 421
Score = 614 bits (1583), Expect = e-176
Identities = 346/510 (67%), Positives = 365/510 (71%), Gaps = 89/510 (17%)
Query: 1 MGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDG 60
MGRPTQWPSLLLLLLLPG P P A G
Sbjct: 1 MGRPTQWPSLLLLLLLPG--------------------PPPVA----------------G 24
Query: 61 LDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFES 120
L+ FP HL LQ LP R LR + + +GL
Sbjct: 25 LEDAAFP--------HLG---ESLQPLP-----RACPLRCSCPRVDTVDCDGLD------ 62
Query: 121 LTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLS 180
L V P + R+ + L NQ+ E+ LR++ LHNN +S
Sbjct: 63 -------------LRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLIS 109
Query: 181 NAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQL 240
+ GLP +AF + L +++N+ NNLISKVPRGALSRQTQL
Sbjct: 110 SEGLPDEAFESLTQLQHLCVAHNK------------------NNLISKVPRGALSRQTQL 151
Query: 241 RELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQV 300
RELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQV
Sbjct: 152 RELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQV 211
Query: 301 EAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRA 360
EAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRA
Sbjct: 212 EAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRA 271
Query: 361 LVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTR 420
LVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTR
Sbjct: 272 LVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTR 331
Query: 421 LPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQ 480
LPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQ
Sbjct: 332 LPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQ 391
Query: 481 VRHRLVSHTVPRAPPSPCLPCHVPNILVSW 510
VRHRLVSHTVPRAPPSPCLPCHVPNILVSW
Sbjct: 392 VRHRLVSHTVPRAPPSPCLPCHVPNILVSW 421
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 456 bits (1174), Expect = e-128
Identities = 236/443 (53%), Positives = 305/443 (68%)
Query: 39 PLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGL 98
P +CP C+C + VDC G+DLR FP ++ HLSLQNNQL+++ ELSRL L
Sbjct: 111 PAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRL 170
Query: 99 RTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEI 158
TLNL NN ++S GLP++AFE LT L +L +A+NKL++AP+FLP +L D AAN + +I
Sbjct: 171 ETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKI 230
Query: 159 FPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLER 218
+ LTFG+KP LRSVYLHNN+L++AGLP + F GS + L LS+N L ++P LPP+L +
Sbjct: 231 YGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYK 290
Query: 219 LHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTT 278
LHL+NN + K+P GA S + LRELYLQ+N LTD GLD TF KL SLEYLDLS N L+
Sbjct: 291 LHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSR 350
Query: 279 VPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLH 338
VPAGLPR+L +LHL +N IR V+A L R L YLLL NQL G+ A + L+ LH
Sbjct: 351 VPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLH 410
Query: 339 TLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVH 398
T+HLY N L+RVP LPRR+R L++ HN + +G D T L ELNL+YNR+ S +VH
Sbjct: 411 TVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVH 470
Query: 399 HRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSL 458
AFR+LR LRSLDL+GN+L LP GLP + L+++RN+L L L G+ QLREL L
Sbjct: 471 RDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYL 530
Query: 459 AHNRLRVGDIGPGTWHELQALQV 481
NRLR +GP W +L LQ+
Sbjct: 531 TSNRLRSRALGPRAWVDLAHLQL 553
Score = 206 bits (524), Expect = 4e-53
Identities = 130/354 (36%), Positives = 188/354 (53%)
Query: 63 LRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLT 122
LR P ++ A L L+NN+L+++P S LS LR L L NN ++ EGL +E F L+
Sbjct: 277 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 336
Query: 123 QLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNA 182
L++L ++ N LS P LPRSL + L N + + +L + LH+NQL
Sbjct: 337 SLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQ 396
Query: 183 GLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRE 242
G+ P AF+G + + T+ L NN L +P LP + L + +N I+ + R + L E
Sbjct: 397 GIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEE 456
Query: 243 LYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEA 302
L L +N++T + F KL L LDLS N+L T+P GLPR + +L + RN + +
Sbjct: 457 LNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALAR 516
Query: 303 ARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV 362
L G LR L L N+L S L A L L L + GN L +P LP L L
Sbjct: 517 GALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLY 576
Query: 363 LPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGN 416
L +N ++A+ A +TP L + L +N+LA V AFRRL+ L+ LD+ GN
Sbjct: 577 LQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
Score = 137 bits (344), Expect = 3e-32
Identities = 98/304 (32%), Positives = 141/304 (46%), Gaps = 3/304 (0%)
Query: 205 LSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLH 264
L P LP L LQNN + K+ LSR +L L LQ+N+LT GL F L
Sbjct: 135 LREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLT 194
Query: 265 SLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSS 324
+L YL L++N+LT P LP L + N + ++ LR + L +N+L +
Sbjct: 195 NLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADA 254
Query: 325 GLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTE 384
GLP + L L N L VP LP L L L +N + + L E
Sbjct: 255 GLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRE 314
Query: 385 LNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEP 444
L L N L + + F +L +L LDL+ N L+R+P GLP L L L++N +R ++
Sbjct: 315 LYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDA 374
Query: 445 EPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSHTVPRAPPSPCLPCHVP 504
L + L L L N+LR I P + L+ L H L ++ + R P LP V
Sbjct: 375 NVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVH-LYNNALERVPSG--LPRRVR 431
Query: 505 NILV 508
+++
Sbjct: 432 TLMI 435
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 154 bits (390), Expect = 1e-37
Identities = 167/520 (32%), Positives = 213/520 (40%), Gaps = 104/520 (20%)
Query: 10 LLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD-----CDGLDLR 64
LLL + GP + G D P GE+ P ACP C C D D C +L
Sbjct: 51 LLLSWVALGPRSLEGA-DPGTP--GEAEGP---ACPAACVCSYDDDADELSVFCSSRNLT 104
Query: 65 VFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQL 124
PD + Q L L N L +P LS L LNL + S L +A L L
Sbjct: 105 RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS--LEPQALLGLENL 162
Query: 125 QHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSN--- 181
HL + N+L RSL + TF PAL S+ L NN+LS
Sbjct: 163 CHLHLERNQL--------RSLALG-------------TFAHTPALASLGLSNNRLSRLED 201
Query: 182 -------------------AGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---------- 212
A LP AFRG ++ L L+ N+L+YL P+L
Sbjct: 202 GLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELREL 261
Query: 213 -----------------PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGL 255
P L++L+L NLI+ V GA LR L L HN++ +GL
Sbjct: 262 DLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV--AGL 319
Query: 256 DATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILH------LGRNRIRQVEAARLHGAR 309
TF L L L LSHN + ++ PRT LH LG NRIRQ+ G
Sbjct: 320 LEDTFPGLLGLRVLRLSHNAIASL---RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG 376
Query: 310 GLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVA 369
L L L HNQL + AGA L + ++L GN L +P + R L L H +
Sbjct: 377 QLEVLTLDHNQL--QEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS 434
Query: 370 ALG---ARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLP 426
LG GL L L N L + ++ L L LDL NQLT LP L
Sbjct: 435 CLGRIRPHTFTGLSGLRRLFLKDNGLVG--IEEQSLWGLAELLELDLTSNQLTHLPHRLF 492
Query: 427 TGLRTLQ---LQRNQLRMLEPEPLAGLDQLRELSLAHNRL 463
GL L+ L RN+L L + L L + L ++HNRL
Sbjct: 493 QGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 532
Score = 103 bits (258), Expect = 3e-22
Identities = 99/274 (36%), Positives = 126/274 (45%), Gaps = 17/274 (6%)
Query: 201 SNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTF 260
S+ L+ LP +P + L L N +S VP A + L L LQ QL L+
Sbjct: 99 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQL--GSLEPQAL 156
Query: 261 SKLHSLEYLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQ 317
L +L +L L NQL ++ G LA L L NR+ ++E G L L L
Sbjct: 157 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 216
Query: 318 HNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGAR 374
N L LP A R L L L L GN L + PAL LR L L N + A+ A
Sbjct: 217 WNSLAV--LPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKAN 274
Query: 375 DLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPM----GLPTGLR 430
V P L +L L N +A+ V AF L+ALR LDL+ N++ L GL GLR
Sbjct: 275 VFVQLPRLQKLYLDRNLIAA--VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGL-LGLR 331
Query: 431 TLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLR 464
L+L N + L P L L EL L HNR+R
Sbjct: 332 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 365
Score = 47.8 bits (112), Expect = 2e-05
Identities = 50/178 (28%), Positives = 80/178 (44%), Gaps = 11/178 (6%)
Query: 53 VDTVDCDGLDLRVFPDNITRAA---QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLIS 109
V ++ G LR P+ + R L L+ + L + + + LSGLR L L +N +
Sbjct: 402 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 461
Query: 110 SEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVAD---LAANQVMEIFPLTFGEK 166
G+ +++ L +L L + N+L+ P L + L + L+ N++ E+ G
Sbjct: 462 --GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALG-- 517
Query: 167 PALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNN 224
P R+ +L + LP + LSL NN L P PP LERL L+ N
Sbjct: 518 PLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ-PPGLERLWLEGN 574
Score = 35.8 bits (81), Expect = 0.095
Identities = 31/94 (32%), Positives = 39/94 (41%), Gaps = 26/94 (27%)
Query: 410 SLDLAGNQLTRLPMGLPTG------------------------LRTLQLQRNQLRMLEPE 445
S+ + LTRLP G+P G L L LQ QL LEP+
Sbjct: 95 SVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQ 154
Query: 446 PLAGLDQLRELSLAHNRLRVGDIGPGTWHELQAL 479
L GL+ L L L N+LR + GT+ AL
Sbjct: 155 ALLGLENLCHLHLERNQLR--SLALGTFAHTPAL 186
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 154 bits (390), Expect = 1e-37
Identities = 167/520 (32%), Positives = 213/520 (40%), Gaps = 104/520 (20%)
Query: 10 LLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD-----CDGLDLR 64
LLL + GP + G D P GE+ P ACP C C D D C +L
Sbjct: 13 LLLSWVALGPRSLEGA-DPGTP--GEAEGP---ACPAACVCSYDDDADELSVFCSSRNLT 66
Query: 65 VFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQL 124
PD + Q L L N L +P LS L LNL + S L +A L L
Sbjct: 67 RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS--LEPQALLGLENL 124
Query: 125 QHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSN--- 181
HL + N+L RSL + TF PAL S+ L NN+LS
Sbjct: 125 CHLHLERNQL--------RSLALG-------------TFAHTPALASLGLSNNRLSRLED 163
Query: 182 -------------------AGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---------- 212
A LP AFRG ++ L L+ N+L+YL P+L
Sbjct: 164 GLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELREL 223
Query: 213 -----------------PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGL 255
P L++L+L NLI+ V GA LR L L HN++ +GL
Sbjct: 224 DLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV--AGL 281
Query: 256 DATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILH------LGRNRIRQVEAARLHGAR 309
TF L L L LSHN + ++ PRT LH LG NRIRQ+ G
Sbjct: 282 LEDTFPGLLGLRVLRLSHNAIASL---RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG 338
Query: 310 GLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVA 369
L L L HNQL + AGA L + ++L GN L +P + R L L H +
Sbjct: 339 QLEVLTLDHNQL--QEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS 396
Query: 370 ALG---ARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLP 426
LG GL L L N L + ++ L L LDL NQLT LP L
Sbjct: 397 CLGRIRPHTFTGLSGLRRLFLKDNGLVG--IEEQSLWGLAELLELDLTSNQLTHLPHRLF 454
Query: 427 TGLRTLQ---LQRNQLRMLEPEPLAGLDQLRELSLAHNRL 463
GL L+ L RN+L L + L L + L ++HNRL
Sbjct: 455 QGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 494
Score = 103 bits (258), Expect = 3e-22
Identities = 99/274 (36%), Positives = 126/274 (45%), Gaps = 17/274 (6%)
Query: 201 SNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTF 260
S+ L+ LP +P + L L N +S VP A + L L LQ QL L+
Sbjct: 61 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQL--GSLEPQAL 118
Query: 261 SKLHSLEYLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQ 317
L +L +L L NQL ++ G LA L L NR+ ++E G L L L
Sbjct: 119 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 178
Query: 318 HNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGAR 374
N L LP A R L L L L GN L + PAL LR L L N + A+ A
Sbjct: 179 WNSLAV--LPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKAN 236
Query: 375 DLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPM----GLPTGLR 430
V P L +L L N +A+ V AF L+ALR LDL+ N++ L GL GLR
Sbjct: 237 VFVQLPRLQKLYLDRNLIAA--VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGL-LGLR 293
Query: 431 TLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLR 464
L+L N + L P L L EL L HNR+R
Sbjct: 294 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
Score = 47.8 bits (112), Expect = 2e-05
Identities = 50/178 (28%), Positives = 80/178 (44%), Gaps = 11/178 (6%)
Query: 53 VDTVDCDGLDLRVFPDNITRAA---QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLIS 109
V ++ G LR P+ + R L L+ + L + + + LSGLR L L +N +
Sbjct: 364 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 423
Query: 110 SEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVAD---LAANQVMEIFPLTFGEK 166
G+ +++ L +L L + N+L+ P L + L + L+ N++ E+ G
Sbjct: 424 --GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALG-- 479
Query: 167 PALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNN 224
P R+ +L + LP + LSL NN L P PP LERL L+ N
Sbjct: 480 PLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ-PPGLERLWLEGN 536
Score = 35.8 bits (81), Expect = 0.095
Identities = 31/94 (32%), Positives = 39/94 (41%), Gaps = 26/94 (27%)
Query: 410 SLDLAGNQLTRLPMGLPTG------------------------LRTLQLQRNQLRMLEPE 445
S+ + LTRLP G+P G L L LQ QL LEP+
Sbjct: 57 SVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQ 116
Query: 446 PLAGLDQLRELSLAHNRLRVGDIGPGTWHELQAL 479
L GL+ L L L N+LR + GT+ AL
Sbjct: 117 ALLGLENLCHLHLERNQLR--SLALGTFAHTPAL 148
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 138 bits (347), Expect = 1e-32
Identities = 137/462 (29%), Positives = 205/462 (44%), Gaps = 49/462 (10%)
Query: 44 CPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNL 103
CP C+C R V+C G + P + A L + N + EL + +S L L +
Sbjct: 31 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 90
Query: 104 HNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPR---SLRVADLAANQVMEIFP 160
N +S + AF +L L++L +A+NKL V P L + SL L++NQ+++I P
Sbjct: 91 EKNELSR--ITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQP 148
Query: 161 LTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLE 217
F + L+ + LH N L +P AF + L+L N L+++ P + +L+
Sbjct: 149 AHFSQCSNLKELQLHGNHLEY--IPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQ 206
Query: 218 RLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLT 277
L L N ++ +P G L+EL LQ NQ+ L F H+L+ L LS+N ++
Sbjct: 207 VLRLYENRLTDIPMGTFDGLVNLQELALQQNQI--GLLSPGLFHNNHNLQRLYLSNNHIS 264
Query: 278 TVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGL 337
+P + L L NR L L N L L G P+ L
Sbjct: 265 QLPPSIFMQLPQL----NR-----------------LTLFGNSL--KELSLGIFGPMPNL 301
Query: 338 HTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLAS 394
L LY N + +P + R+L+ L+L N ++ + L EL+L N L
Sbjct: 302 RELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQD 361
Query: 395 ARVHHRAFRRLRALRSLDLAGNQLTRLPMGL---PTGLRTLQLQRNQLRMLEPEPLAGLD 451
+ FR L L+++ L N+L +LP + GL +QLQ NQL L L
Sbjct: 362 --LDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLG 419
Query: 452 QLRELSLAHNRLRV-GDIGP-GTWHELQALQVRHRLVSHTVP 491
+L EL L N R DI P W L + RL + TVP
Sbjct: 420 KLCELRLYDNPWRCDSDILPLRNW----LLLNQPRLGTDTVP 457
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 138 bits (347), Expect = 1e-32
Identities = 137/462 (29%), Positives = 205/462 (44%), Gaps = 49/462 (10%)
Query: 44 CPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNL 103
CP C+C R V+C G + P + A L + N + EL + +S L L +
Sbjct: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
Query: 104 HNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPR---SLRVADLAANQVMEIFP 160
N +S + AF +L L++L +A+NKL V P L + SL L++NQ+++I P
Sbjct: 85 EKNELSR--ITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQP 142
Query: 161 LTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLE 217
F + L+ + LH N L +P AF + L+L N L+++ P + +L+
Sbjct: 143 AHFSQCSNLKELQLHGNHLEY--IPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQ 200
Query: 218 RLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLT 277
L L N ++ +P G L+EL LQ NQ+ L F H+L+ L LS+N ++
Sbjct: 201 VLRLYENRLTDIPMGTFDGLVNLQELALQQNQI--GLLSPGLFHNNHNLQRLYLSNNHIS 258
Query: 278 TVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGL 337
+P + L L NR L L N L L G P+ L
Sbjct: 259 QLPPSIFMQLPQL----NR-----------------LTLFGNSL--KELSLGIFGPMPNL 295
Query: 338 HTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLAS 394
L LY N + +P + R+L+ L+L N ++ + L EL+L N L
Sbjct: 296 RELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQD 355
Query: 395 ARVHHRAFRRLRALRSLDLAGNQLTRLPMGL---PTGLRTLQLQRNQLRMLEPEPLAGLD 451
+ FR L L+++ L N+L +LP + GL +QLQ NQL L L
Sbjct: 356 --LDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLG 413
Query: 452 QLRELSLAHNRLRV-GDIGP-GTWHELQALQVRHRLVSHTVP 491
+L EL L N R DI P W L + RL + TVP
Sbjct: 414 KLCELRLYDNPWRCDSDILPLRNW----LLLNQPRLGTDTVP 451
>gi|41349454 proline arginine-rich end leucine-rich repeat protein
precursor [Homo sapiens]
Length = 382
Score = 138 bits (347), Expect = 1e-32
Identities = 101/320 (31%), Positives = 149/320 (46%), Gaps = 33/320 (10%)
Query: 19 PPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPR--VDTVDCDGLDLRVFPDNITRAAQH 76
PPP+ + FP CP C CP + CD +LR P I +
Sbjct: 59 PPPLPPGPPSIFPD-----------CPRECYCPPDFPSALYCDSRNLRKVPV-IPPRIHY 106
Query: 77 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 136
L LQNN + ELP +GLR +NL NN I + E L L L + N+L
Sbjct: 107 LYLQNNFITELPVESFQNATGLRWINLDNNRIRK--IDQRVLEKLPGLVFLYMEKNQLEE 164
Query: 137 APQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIA 196
P LPR+L L+ N + I P F + L + L +N+LS+ PD F G + +
Sbjct: 165 VPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLKNLM 224
Query: 197 TLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLD 256
L+L++N L +PP +P ++ +L+L +N I +P G L + L +N+LTD GL
Sbjct: 225 QLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTDRGLP 284
Query: 257 ATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAAR------------ 304
+F+ + +L L LSHN++++VPA + L L+L N I ++ +
Sbjct: 285 KNSFN-ISNLLVLHLSHNRISSVPA-INNRLEHLYLNNNSIEKINGTQICPNDLVAFHDF 342
Query: 305 ---LHGARGLRYLLLQHNQL 321
L LRYL L N L
Sbjct: 343 SSDLENVPHLRYLRLDGNYL 362
Score = 103 bits (256), Expect = 5e-22
Identities = 84/294 (28%), Positives = 129/294 (43%), Gaps = 16/294 (5%)
Query: 141 LPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSL 200
+P + L N + E+ +F LR + L NN++ + + L +
Sbjct: 100 IPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRK--IDQRVLEKLPGLVFLYM 157
Query: 201 SNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTF 260
NQL +P +LP +LE+L L N IS++P G S+ L L LQHN+L+D TF
Sbjct: 158 EKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTF 217
Query: 261 SKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQ 320
L +L L+L+HN L +P +P + L+L N+I + L ++ L +N+
Sbjct: 218 HGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNK 277
Query: 321 LGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATP 380
L GLP + + L LHL N + V PA+ RL L L +N + + +
Sbjct: 278 LTDRGLPKNSFN-ISNLLVLHLSHNRISSV-PAINNRLEHLYLNNNSIEKINGTQICP-- 333
Query: 381 GLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQL-TRLPMGLPTGLRTLQ 433
N L + + LR L L GN L +P+ L R LQ
Sbjct: 334 ---------NDLVAFHDFSSDLENVPHLRYLRLDGNYLKPPIPLDLMMCFRLLQ 378
Score = 79.0 bits (193), Expect = 1e-14
Identities = 60/214 (28%), Positives = 98/214 (45%), Gaps = 5/214 (2%)
Query: 276 LTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLR 335
L VP +P + L+L N I ++ A GLR++ L +N++ + L L
Sbjct: 94 LRKVPV-IPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRK--IDQRVLEKLP 150
Query: 336 GLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASA 395
GL L++ N L+ VP ALPR L L L NH++ + L L+L +NRL+
Sbjct: 151 GLVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDG 210
Query: 396 RVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRE 455
F L+ L L+LA N L ++P +PT + L L N++ + L
Sbjct: 211 VFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAF 270
Query: 456 LSLAHNRLRVGDIGPGTWH--ELQALQVRHRLVS 487
+ L +N+L + +++ L L + H +S
Sbjct: 271 IRLNYNKLTDRGLPKNSFNISNLLVLHLSHNRIS 304
>gi|4506041 proline arginine-rich end leucine-rich repeat protein
precursor [Homo sapiens]
Length = 382
Score = 138 bits (347), Expect = 1e-32
Identities = 101/320 (31%), Positives = 149/320 (46%), Gaps = 33/320 (10%)
Query: 19 PPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPR--VDTVDCDGLDLRVFPDNITRAAQH 76
PPP+ + FP CP C CP + CD +LR P I +
Sbjct: 59 PPPLPPGPPSIFPD-----------CPRECYCPPDFPSALYCDSRNLRKVPV-IPPRIHY 106
Query: 77 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 136
L LQNN + ELP +GLR +NL NN I + E L L L + N+L
Sbjct: 107 LYLQNNFITELPVESFQNATGLRWINLDNNRIRK--IDQRVLEKLPGLVFLYMEKNQLEE 164
Query: 137 APQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIA 196
P LPR+L L+ N + I P F + L + L +N+LS+ PD F G + +
Sbjct: 165 VPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLKNLM 224
Query: 197 TLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLD 256
L+L++N L +PP +P ++ +L+L +N I +P G L + L +N+LTD GL
Sbjct: 225 QLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTDRGLP 284
Query: 257 ATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAAR------------ 304
+F+ + +L L LSHN++++VPA + L L+L N I ++ +
Sbjct: 285 KNSFN-ISNLLVLHLSHNRISSVPA-INNRLEHLYLNNNSIEKINGTQICPNDLVAFHDF 342
Query: 305 ---LHGARGLRYLLLQHNQL 321
L LRYL L N L
Sbjct: 343 SSDLENVPHLRYLRLDGNYL 362
Score = 103 bits (256), Expect = 5e-22
Identities = 84/294 (28%), Positives = 129/294 (43%), Gaps = 16/294 (5%)
Query: 141 LPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSL 200
+P + L N + E+ +F LR + L NN++ + + L +
Sbjct: 100 IPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRK--IDQRVLEKLPGLVFLYM 157
Query: 201 SNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTF 260
NQL +P +LP +LE+L L N IS++P G S+ L L LQHN+L+D TF
Sbjct: 158 EKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTF 217
Query: 261 SKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQ 320
L +L L+L+HN L +P +P + L+L N+I + L ++ L +N+
Sbjct: 218 HGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNK 277
Query: 321 LGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATP 380
L GLP + + L LHL N + V PA+ RL L L +N + + +
Sbjct: 278 LTDRGLPKNSFN-ISNLLVLHLSHNRISSV-PAINNRLEHLYLNNNSIEKINGTQICP-- 333
Query: 381 GLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQL-TRLPMGLPTGLRTLQ 433
N L + + LR L L GN L +P+ L R LQ
Sbjct: 334 ---------NDLVAFHDFSSDLENVPHLRYLRLDGNYLKPPIPLDLMMCFRLLQ 378
Score = 79.0 bits (193), Expect = 1e-14
Identities = 60/214 (28%), Positives = 98/214 (45%), Gaps = 5/214 (2%)
Query: 276 LTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLR 335
L VP +P + L+L N I ++ A GLR++ L +N++ + L L
Sbjct: 94 LRKVPV-IPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRK--IDQRVLEKLP 150
Query: 336 GLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASA 395
GL L++ N L+ VP ALPR L L L NH++ + L L+L +NRL+
Sbjct: 151 GLVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDG 210
Query: 396 RVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRE 455
F L+ L L+LA N L ++P +PT + L L N++ + L
Sbjct: 211 VFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAF 270
Query: 456 LSLAHNRLRVGDIGPGTWH--ELQALQVRHRLVS 487
+ L +N+L + +++ L L + H +S
Sbjct: 271 IRLNYNKLTDRGLPKNSFNISNLLVLHLSHNRIS 304
>gi|71040111 fibromodulin precursor [Homo sapiens]
Length = 376
Score = 137 bits (346), Expect = 2e-32
Identities = 100/320 (31%), Positives = 156/320 (48%), Gaps = 14/320 (4%)
Query: 24 GLEDAAFPHLGESLQPLPRACPLRCSCPR--VDTVDCDGLDLRVFPDNITRAAQHLSLQN 81
G+++ G P PR CP C CP + CD +L+ P +R +++ QN
Sbjct: 56 GVDEGPAYTYGSPSPPDPRDCPQECDCPPNFPTAMYCDNRNLKYLPFVPSRM-KYVYFQN 114
Query: 82 NQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFL 141
NQ+ + +GL + LH N I+S+ + + F L L+ L + HN L+ P L
Sbjct: 115 NQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMPGPL 174
Query: 142 PRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLS 201
PRSLR L NQ+ + L ++YL +N++ G + RG ++ L LS
Sbjct: 175 PRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVG---SSMRGLRSLILLDLS 231
Query: 202 NNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFS 261
N L +P LP +LE+L++++N + VP +L + L HN LT++GL + TF+
Sbjct: 232 YNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLTNNGLASNTFN 291
Query: 262 KLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAAR------LHGARGLRYLL 315
LE LDLS+NQL +P + L L+L NRI + + + L+ L
Sbjct: 292 SSSLLE-LDLSYNQLQKIPP-VNTNLENLYLQGNRINEFSISSFCTVVDVVNFSKLQVLR 349
Query: 316 LQHNQLGSSGLPAGALRPLR 335
L N++ S +PA A LR
Sbjct: 350 LDGNEIKRSAMPADAPLCLR 369
Score = 126 bits (317), Expect = 4e-29
Identities = 86/238 (36%), Positives = 120/238 (50%), Gaps = 6/238 (2%)
Query: 202 NNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFS 261
N L YLP +P ++ ++ QNN I+ + G T L + L NQ+T + FS
Sbjct: 94 NRNLKYLP-FVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFS 152
Query: 262 KLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQL 321
KL LE L L HN LT +P LPR+L LHL N+I +V L G L L LQHN++
Sbjct: 153 KLRHLERLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEI 212
Query: 322 GSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPG 381
G ++R LR L L L N L +VP LP L L + HN+V + P
Sbjct: 213 QEVG---SSMRGLRSLILLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPK 269
Query: 382 LTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQL 439
L + L++N L + + F +L LDL+ NQL ++P + T L L LQ N++
Sbjct: 270 LLYVRLSHNSLTNNGLASNTFNS-SSLLELDLSYNQLQKIP-PVNTNLENLYLQGNRI 325
Score = 115 bits (288), Expect = 9e-26
Identities = 78/229 (34%), Positives = 111/229 (48%), Gaps = 5/229 (2%)
Query: 140 FLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLS 199
F+P ++ NQ+ I F L + LH NQ+++ + F + L
Sbjct: 102 FVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLY 161
Query: 200 LSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATT 259
L +N L+ +P LP SL LHL +N IS+VP AL L LYLQHN++ + G ++
Sbjct: 162 LDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVG---SS 218
Query: 260 FSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHN 319
L SL LDLS+N L VP GLP L L++ N + V + GA L Y+ L HN
Sbjct: 219 MRGLRSLILLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHN 278
Query: 320 QLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHV 368
L ++GL + L L L N L ++PP + L L L N +
Sbjct: 279 SLTNNGLASNTFNS-SSLLELDLSYNQLQKIPP-VNTNLENLYLQGNRI 325
Score = 89.4 bits (220), Expect = 7e-18
Identities = 58/199 (29%), Positives = 94/199 (47%), Gaps = 3/199 (1%)
Query: 283 LPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHL 342
+P + ++ N+I ++ A GL ++ L NQ+ S + LR L L+L
Sbjct: 103 VPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYL 162
Query: 343 YGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAF 402
N L R+P LPR LR L L HN ++ + L LT L L +N + +
Sbjct: 163 DHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVG---SSM 219
Query: 403 RRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNR 462
R LR+L LDL+ N L ++P GLP+ L L ++ N + + G +L + L+HN
Sbjct: 220 RGLRSLILLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNS 279
Query: 463 LRVGDIGPGTWHELQALQV 481
L + T++ L++
Sbjct: 280 LTNNGLASNTFNSSSLLEL 298
Score = 63.9 bits (154), Expect = 3e-10
Identities = 37/113 (32%), Positives = 57/113 (50%)
Query: 352 PALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSL 411
P +P R++ + +N + ++ GL + L N++ S +V + F +LR L L
Sbjct: 101 PFVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERL 160
Query: 412 DLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLR 464
L N LTR+P LP LR L L NQ+ + L GL+ L L L HN ++
Sbjct: 161 YLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQ 213
>gi|5901992 keratocan [Homo sapiens]
Length = 352
Score = 134 bits (337), Expect = 2e-31
Identities = 89/262 (33%), Positives = 132/262 (50%), Gaps = 5/262 (1%)
Query: 44 CPLRCSCPRV--DTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTL 101
CP+ C CP + C+ L+ P I +L LQNN ++ +P + LR +
Sbjct: 42 CPMECFCPPSFPTALYCENRGLKEIPA-IPSRIWYLYLQNNLIETIPEKPFENATQLRWI 100
Query: 102 NLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPL 161
NL+ N I++ G+ A L +L L + N+L P LPRSL LA N+V I
Sbjct: 101 NLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQG 160
Query: 162 TFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHL 221
TF L + L NN+L + D F+G + + L+++ N L +PP LP + +L L
Sbjct: 161 TFSNLENLTLLDLQNNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFL 220
Query: 222 QNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPA 281
NN I +P + ++ L L HN+L+D GL + F + S+ L LSHNQLT VP
Sbjct: 221 DNNSIEGIPENYFNVIPKVAFLRLNHNKLSDEGLPSRGFD-VSSILDLQLSHNQLTKVPR 279
Query: 282 GLPRTLAILHLGRNRIRQVEAA 303
+ L LHL N+I+ V +
Sbjct: 280 -ISAHLQHLHLDHNKIKSVNVS 300
Score = 116 bits (291), Expect = 4e-26
Identities = 71/231 (30%), Positives = 118/231 (51%), Gaps = 2/231 (0%)
Query: 210 PSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYL 269
P++P + L+LQNNLI +P TQLR + L N++T+ G++ S+L L +L
Sbjct: 67 PAIPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEKGALSQLKKLLFL 126
Query: 270 DLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAG 329
L N+L VP+ LPR+L L L RN++ ++ L L LQ+N+L +
Sbjct: 127 FLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQNNKLVDNAFQRD 186
Query: 330 ALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAY 389
+ L+ L L++ N L +PP LP L L +N + + P + L L +
Sbjct: 187 TFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFLDNNSIEGIPENYFNVIPKVAFLRLNH 246
Query: 390 NRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLR 440
N+L+ + R F + ++ L L+ NQLT++P + L+ L L N+++
Sbjct: 247 NKLSDEGLPSRGF-DVSSILDLQLSHNQLTKVPR-ISAHLQHLHLDHNKIK 295
Score = 108 bits (269), Expect = 2e-23
Identities = 83/283 (29%), Positives = 130/283 (45%), Gaps = 16/283 (5%)
Query: 153 NQVMEIFP-LTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPS 211
N ++E P F LR + L+ N+++N G+ A + + L L +N+L +P
Sbjct: 80 NNLIETIPEKPFENATQLRWINLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSP 139
Query: 212 LPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDL 271
LP SLE+L L N +S++P+G S L L LQ+N+L D+ TF L +L L++
Sbjct: 140 LPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQNNKLVDNAFQRDTFKGLKNLMQLNM 199
Query: 272 SHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGAL 331
+ N L +P LP L L N I + + + +L L HN+L GLP+
Sbjct: 200 AKNALRNMPPRLPANTMQLFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSDEGLPSRGF 259
Query: 332 RPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNR 391
+ + L L N L +V P + L+ L L HN + ++ + +P +
Sbjct: 260 -DVSSILDLQLSHNQLTKV-PRISAHLQHLHLDHNKIKSVNVSVICPSPSMLP------- 310
Query: 392 LASARVHHRAFRRLRALRSLDLAGNQL-TRLPMGLPTGLRTLQ 433
+F LR L L GN++ +PM L T R LQ
Sbjct: 311 -----AERDSFSYGPHLRYLRLDGNEIKPPIPMALMTCFRLLQ 348
Score = 79.7 bits (195), Expect = 6e-15
Identities = 57/188 (30%), Positives = 85/188 (45%), Gaps = 1/188 (0%)
Query: 276 LTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLR 335
L +PA +P + L+L N I + A LR++ L N++ + G+ GAL L+
Sbjct: 63 LKEIPA-IPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEKGALSQLK 121
Query: 336 GLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASA 395
L L L N L+ VP LPR L L L N V+ + LT L+L N+L
Sbjct: 122 KLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQNNKLVDN 181
Query: 396 RVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRE 455
F+ L+ L L++A N L +P LP L L N + + + ++
Sbjct: 182 AFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFLDNNSIEGIPENYFNVIPKVAF 241
Query: 456 LSLAHNRL 463
L L HN+L
Sbjct: 242 LRLNHNKL 249
>gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens]
Length = 699
Score = 131 bits (329), Expect = 2e-30
Identities = 95/344 (27%), Positives = 165/344 (47%), Gaps = 9/344 (2%)
Query: 134 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 193
L+ P + +L N + I F P L + L N ++++G+ P AF+ +
Sbjct: 334 LTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLK 393
Query: 194 AIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 253
+ L++ N L +P LP +LE L + N + + +LS QL L L+ N L+++
Sbjct: 394 KLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEA 453
Query: 254 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 313
++ F L SL YL L N+ +P GLP ++ L+L N+I ++ + R +
Sbjct: 454 NVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINV 513
Query: 314 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAAL-G 372
++L++N++ + + A L ++ L N L VP LP+ L LVL N + + G
Sbjct: 514 IVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPG 573
Query: 373 ARDLVATPGLTELNLAYNRLASARVHHRAFR-RLRALRSLDLAGNQLTRLPMGLPT--GL 429
PGL L L++N+LA + +F +LR L L N L +P G+ L
Sbjct: 574 YVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKAL 633
Query: 430 RTLQLQRNQLRMLEPEPLAGLDQ-----LRELSLAHNRLRVGDI 468
L+L N++R + PE + ++ L L L +N +++ +I
Sbjct: 634 HFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREI 677
Score = 129 bits (324), Expect = 6e-30
Identities = 105/386 (27%), Positives = 173/386 (44%), Gaps = 20/386 (5%)
Query: 40 LPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLR 99
LP C L T+ C L P L L N + +P + L L
Sbjct: 316 LPSGCSLSYR-----TISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLE 370
Query: 100 TLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIF 159
L+L N I+S G+ +AF+ L +L L + N L P LP +L + N + I
Sbjct: 371 RLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAID 430
Query: 160 PLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERL 219
+ + L ++ L N LS A + P AF+ +++A L L N+ +P LP S+E L
Sbjct: 431 EESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEEL 490
Query: 220 HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTV 279
+L+NN I ++ + ++ + L++N++ ++ + + +LE +DLS+N+L V
Sbjct: 491 YLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHV 550
Query: 280 PAGLPRTLAILHLGRNRIRQVEAARL-HGARGLRYLLLQHNQLGSSGLPA----GALRPL 334
P+ LP++L L L N+I ++ H GL YL L N+L G+ GA L
Sbjct: 551 PSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSL 610
Query: 335 RGLHTLHLYGNGLDRVPPALP--RRLRALVLPHNHVAALGARDLVAT-----PGLTELNL 387
R L H N L +PP + + L L L +N + + ++ L L+L
Sbjct: 611 RELFLDH---NDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHL 667
Query: 388 AYNRLASARVHHRAFRRLRALRSLDL 413
N + + F +R+ S+ L
Sbjct: 668 ENNYIKIREIPSYTFSCIRSYSSIVL 693
Score = 110 bits (275), Expect = 3e-24
Identities = 84/294 (28%), Positives = 131/294 (44%), Gaps = 9/294 (3%)
Query: 197 TLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLD 256
T+S N L+ +PP P + L L N I+ +P A + L L L N +T SG+
Sbjct: 326 TISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIG 385
Query: 257 ATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLL 316
F L L L++ N L +P+ LP TL L + N ++ ++ L L L L
Sbjct: 386 PKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLEL 445
Query: 317 QHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDL 376
+ N L + + A +PL+ L L L N +P LP + L L +N + +
Sbjct: 446 EGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICF 505
Query: 377 VATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQR 436
T + + L YN++ R+ A+ L S+DL+ N+L +P LP L L L
Sbjct: 506 NHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLG 565
Query: 437 NQLRMLEPEPLAGLDQ-LRELSLAHNRLRVGDIGP------GTWHELQALQVRH 483
NQ+ + ++ L L L+ N+L D G G +H L+ L + H
Sbjct: 566 NQIERIPGYVFGHMEPGLEYLYLSFNKL--ADDGMDRVSFYGAYHSLRELFLDH 617
>gi|4505047 lumican precursor [Homo sapiens]
Length = 338
Score = 124 bits (310), Expect = 3e-28
Identities = 90/300 (30%), Positives = 150/300 (50%), Gaps = 14/300 (4%)
Query: 44 CPLRCSCPRV--DTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTL 101
C C+CP + CD L L+ P + ++L L+NNQ+ + ++ L+ L
Sbjct: 37 CAPECNCPESYPSAMYCDELKLKSVP-MVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWL 95
Query: 102 NLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPL 161
L +NL+ + + F L QL+ L + HN L+ + LP+SL L N++ ++
Sbjct: 96 ILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKLG-- 153
Query: 162 TFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHL 221
+F L ++L +N+L + AF+G +++ L LS NQ++ LP LP SL L+L
Sbjct: 154 SFEGLVNLTFIHLQHNRLKEDAVSA-AFKGLKSLEYLDLSFNQIARLPSGLPVSLLTLYL 212
Query: 222 QNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPA 281
NN IS +P R L+ L L HN+L DSG+ +F+ + SL LDLS+N+L +P
Sbjct: 213 DNNKISNIPDEYFKRFNALQYLRLSHNELADSGIPGNSFN-VSSLVELDLSYNKLKNIPT 271
Query: 282 GLPRTLAILHLGRNRIRQVEAARLHGARG------LRYLLLQHNQLGSSGLPAGALRPLR 335
+ L +L N++ + + G +++L L N++ + LP LR
Sbjct: 272 -VNENLENYYLEVNQLEKFDIKSFCKILGPLSYSKIKHLRLDGNRISETSLPPDMYECLR 330
Score = 108 bits (270), Expect = 1e-23
Identities = 81/274 (29%), Positives = 132/274 (48%), Gaps = 11/274 (4%)
Query: 210 PSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYL 269
P +PP ++ L+L+NN I + A T L+ L L HN L +S + FSKL L+ L
Sbjct: 62 PMVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKL 121
Query: 270 DLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAG 329
++HN LT LP++L L L N+I ++ G L ++ LQHN+L + A
Sbjct: 122 HINHNNLTESVGPLPKSLEDLQLTHNKITKL--GSFEGLVNLTFIHLQHNRLKEDAVSA- 178
Query: 330 ALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAY 389
A + L+ L L L N + R+P LP L L L +N ++ + L L L++
Sbjct: 179 AFKGLKSLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKRFNALQYLRLSH 238
Query: 390 NRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAG 449
N LA + + +F + +L LDL+ N+L +P + L L+ NQL + +
Sbjct: 239 NELADSGIPGNSF-NVSSLVELDLSYNKLKNIPT-VNENLENYYLEVNQLEKFDIKSFCK 296
Query: 450 L------DQLRELSLAHNRLRVGDIGPGTWHELQ 477
+ +++ L L NR+ + P + L+
Sbjct: 297 ILGPLSYSKIKHLRLDGNRISETSLPPDMYECLR 330
Score = 31.6 bits (70), Expect = 1.8
Identities = 22/83 (26%), Positives = 41/83 (49%), Gaps = 4/83 (4%)
Query: 417 QLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTW--- 473
+L +PM +P G++ L L+ NQ+ ++ + + L+ L L HN L I +
Sbjct: 57 KLKSVPM-VPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKL 115
Query: 474 HELQALQVRHRLVSHTVPRAPPS 496
+L+ L + H ++ +V P S
Sbjct: 116 KQLKKLHINHNNLTESVGPLPKS 138
>gi|41350214 asporin [Homo sapiens]
Length = 380
Score = 124 bits (310), Expect = 3e-28
Identities = 87/260 (33%), Positives = 139/260 (53%), Gaps = 10/260 (3%)
Query: 44 CPLRCSC-PRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLN 102
CP C C RV V C L L P NI + L LQNN+++E+ N+ L+ L L
Sbjct: 75 CPFGCQCYSRV--VHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLI 132
Query: 103 LHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLT 162
L+NN ++ + +AF + +L+ L ++HN+LS P LP+SL + N+V +I T
Sbjct: 133 LNNNKLTK--IHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDT 190
Query: 163 FGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQ 222
F AL + + N L N G+ P AF G + + ++ +L+ +P LPP+L LHL
Sbjct: 191 FKGMNALHVLEMSANPLDNNGIEPGAFEG-VTVFHIRIAEAKLTSVPKGLPPTLLELHLD 249
Query: 223 NNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAG 282
N IS V R +L+ L L +N++TD ++ + + + + + L +N+L +P+G
Sbjct: 250 YNKISTVELEDFKRYKELQRLGLGNNKITD--IENGSLANIPRVREIHLENNKLKKIPSG 307
Query: 283 LP--RTLAILHLGRNRIRQV 300
LP + L I+ L N I +V
Sbjct: 308 LPELKYLQIIFLHSNSIARV 327
Score = 110 bits (276), Expect = 2e-24
Identities = 75/248 (30%), Positives = 129/248 (52%), Gaps = 7/248 (2%)
Query: 134 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 193
L+ P +P R+ DL N++ EI F +L + L+NN+L+ + P AF ++
Sbjct: 93 LTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTK--IHPKAFLTTK 150
Query: 194 AIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 253
+ L LS+NQLS +P +LP SL L + N + K+ + L L + N L ++
Sbjct: 151 KLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNN 210
Query: 254 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 313
G++ F + ++ ++ ++ +LT+VP GLP TL LHL N+I VE + L+
Sbjct: 211 GIEPGAFEGV-TVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQR 269
Query: 314 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALP--RRLRALVLPHNHVAAL 371
L L +N++ + + G+L + + +HL N L ++P LP + L+ + L N +A +
Sbjct: 270 LGLGNNKI--TDIENGSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARV 327
Query: 372 GARDLVAT 379
G D T
Sbjct: 328 GVNDFCPT 335
Score = 97.8 bits (242), Expect = 2e-20
Identities = 66/230 (28%), Positives = 110/230 (47%), Gaps = 6/230 (2%)
Query: 205 LSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLH 264
L+ +P ++P L LQNN I ++ T L L L +N+LT + F
Sbjct: 93 LTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTK--IHPKAFLTTK 150
Query: 265 SLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSS 324
L L LSHNQL+ +P LP++LA L + N++++++ G L L + N L ++
Sbjct: 151 KLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNN 210
Query: 325 GLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTE 384
G+ GA + H + + L VP LP L L L +N ++ + D L
Sbjct: 211 GIEPGAFEGVTVFH-IRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQR 269
Query: 385 LNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQL 434
L L N++ + + + + +R + L N+L ++P GLP L+ LQ+
Sbjct: 270 LGLGNNKITD--IENGSLANIPRVREIHLENNKLKKIPSGLPE-LKYLQI 316
Score = 71.6 bits (174), Expect = 2e-12
Identities = 47/165 (28%), Positives = 78/165 (47%), Gaps = 3/165 (1%)
Query: 340 LHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHH 399
+H GL VP +P R L L +N + + D L L L N+L ++H
Sbjct: 86 VHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLT--KIHP 143
Query: 400 RAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLA 459
+AF + LR L L+ NQL+ +P+ LP L L++ N+++ ++ + G++ L L ++
Sbjct: 144 KAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMS 203
Query: 460 HNRLRVGDIGPGTWHELQALQVRHRLVSHT-VPRAPPSPCLPCHV 503
N L I PG + + +R T VP+ P L H+
Sbjct: 204 ANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHL 248
>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 122 bits (307), Expect = 6e-28
Identities = 78/259 (30%), Positives = 131/259 (50%), Gaps = 7/259 (2%)
Query: 44 CPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNL 103
CP RC C + V C L L P ++ L LQNN++ E+ + L L L L
Sbjct: 54 CPFRCQC-HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALIL 112
Query: 104 HNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTF 163
NN IS + AF L +L+ L ++ N+L P+ +P++L+ N++ ++ +TF
Sbjct: 113 VNNKISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTF 170
Query: 164 GEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQN 223
+ + L N L ++G+ AF+G + ++ + +++ ++ +P LPPSL LHL
Sbjct: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDG 230
Query: 224 NLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGL 283
N IS+V +L L +L L N + S +D + + L L L +N+LT VP GL
Sbjct: 231 NKISRVDAASLKGLNNLAKLGLSFNSI--SAVDNGSLANTPHLRELHLDNNKLTRVPGGL 288
Query: 284 P--RTLAILHLGRNRIRQV 300
+ + +++L N I V
Sbjct: 289 AEHKYIQVVYLHNNNISVV 307
Score = 117 bits (292), Expect = 3e-26
Identities = 82/259 (31%), Positives = 127/259 (49%), Gaps = 7/259 (2%)
Query: 134 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 193
L P+ LP + DL N++ EI F L ++ L NN++S P AF
Sbjct: 72 LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVS--PGAFTPLV 129
Query: 194 AIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 253
+ L LS NQL LP +P +L+ L N I+KV + + Q+ + L N L S
Sbjct: 130 KLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189
Query: 254 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 313
G++ F + L Y+ ++ +T++P GLP +L LHL N+I +V+AA L G L
Sbjct: 190 GIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAK 249
Query: 314 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALP--RRLRALVLPHNHVAAL 371
L L N + S + G+L L LHL N L RVP L + ++ + L +N+++ +
Sbjct: 250 LGLSFNSI--SAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVV 307
Query: 372 GARDLVATPGLTELNLAYN 390
G+ D PG +Y+
Sbjct: 308 GSSDF-CPPGHNTKKASYS 325
Score = 102 bits (255), Expect = 6e-22
Identities = 74/241 (30%), Positives = 114/241 (47%), Gaps = 4/241 (1%)
Query: 185 PPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELY 244
P FR + + S+ L +P LPP L LQNN I+++ G L L
Sbjct: 52 PVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
Query: 245 LQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAAR 304
L +N++ S + F+ L LE L LS NQL +P +P+TL L N I +V
Sbjct: 112 LVNNKI--SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169
Query: 305 LHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLP 364
+G + + L N L SSG+ GA + ++ L + + + +P LP L L L
Sbjct: 170 FNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLD 229
Query: 365 HNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMG 424
N ++ + A L L +L L++N +++ V + + LR L L N+LTR+P G
Sbjct: 230 GNKISRVDAASLKGLNNLAKLGLSFNSISA--VDNGSLANTPHLRELHLDNNKLTRVPGG 287
Query: 425 L 425
L
Sbjct: 288 L 288
Score = 84.3 bits (207), Expect = 2e-16
Identities = 56/204 (27%), Positives = 95/204 (46%), Gaps = 2/204 (0%)
Query: 266 LEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSG 325
L + S L VP LP +L L N+I +++ + L L+L +N++ S
Sbjct: 62 LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKI--SK 119
Query: 326 LPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTEL 385
+ GA PL L L+L N L +P +P+ L+ L N + + + +
Sbjct: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
Query: 386 NLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPE 445
L N L S+ + + AF+ ++ L + +A +T +P GLP L L L N++ ++
Sbjct: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
Query: 446 PLAGLDQLRELSLAHNRLRVGDIG 469
L GL+ L +L L+ N + D G
Sbjct: 240 SLKGLNNLAKLGLSFNSISAVDNG 263
Score = 53.9 bits (128), Expect = 3e-07
Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 2/134 (1%)
Query: 346 GLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRL 405
GLD+VP LP L L +N + + D L L L N+++ +V AF L
Sbjct: 71 GLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKIS--KVSPGAFTPL 128
Query: 406 RALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 465
L L L+ NQL LP +P L+ L+ N++ + GL+Q+ + L N L+
Sbjct: 129 VKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKS 188
Query: 466 GDIGPGTWHELQAL 479
I G + ++ L
Sbjct: 189 SGIENGAFQGMKKL 202
>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 122 bits (307), Expect = 6e-28
Identities = 78/259 (30%), Positives = 131/259 (50%), Gaps = 7/259 (2%)
Query: 44 CPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNL 103
CP RC C + V C L L P ++ L LQNN++ E+ + L L L L
Sbjct: 54 CPFRCQC-HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALIL 112
Query: 104 HNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTF 163
NN IS + AF L +L+ L ++ N+L P+ +P++L+ N++ ++ +TF
Sbjct: 113 VNNKISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTF 170
Query: 164 GEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQN 223
+ + L N L ++G+ AF+G + ++ + +++ ++ +P LPPSL LHL
Sbjct: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDG 230
Query: 224 NLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGL 283
N IS+V +L L +L L N + S +D + + L L L +N+LT VP GL
Sbjct: 231 NKISRVDAASLKGLNNLAKLGLSFNSI--SAVDNGSLANTPHLRELHLDNNKLTRVPGGL 288
Query: 284 P--RTLAILHLGRNRIRQV 300
+ + +++L N I V
Sbjct: 289 AEHKYIQVVYLHNNNISVV 307
Score = 117 bits (292), Expect = 3e-26
Identities = 82/259 (31%), Positives = 127/259 (49%), Gaps = 7/259 (2%)
Query: 134 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 193
L P+ LP + DL N++ EI F L ++ L NN++S P AF
Sbjct: 72 LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVS--PGAFTPLV 129
Query: 194 AIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 253
+ L LS NQL LP +P +L+ L N I+KV + + Q+ + L N L S
Sbjct: 130 KLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189
Query: 254 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 313
G++ F + L Y+ ++ +T++P GLP +L LHL N+I +V+AA L G L
Sbjct: 190 GIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAK 249
Query: 314 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALP--RRLRALVLPHNHVAAL 371
L L N + S + G+L L LHL N L RVP L + ++ + L +N+++ +
Sbjct: 250 LGLSFNSI--SAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVV 307
Query: 372 GARDLVATPGLTELNLAYN 390
G+ D PG +Y+
Sbjct: 308 GSSDF-CPPGHNTKKASYS 325
Score = 102 bits (255), Expect = 6e-22
Identities = 74/241 (30%), Positives = 114/241 (47%), Gaps = 4/241 (1%)
Query: 185 PPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELY 244
P FR + + S+ L +P LPP L LQNN I+++ G L L
Sbjct: 52 PVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
Query: 245 LQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAAR 304
L +N++ S + F+ L LE L LS NQL +P +P+TL L N I +V
Sbjct: 112 LVNNKI--SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169
Query: 305 LHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLP 364
+G + + L N L SSG+ GA + ++ L + + + +P LP L L L
Sbjct: 170 FNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLD 229
Query: 365 HNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMG 424
N ++ + A L L +L L++N +++ V + + LR L L N+LTR+P G
Sbjct: 230 GNKISRVDAASLKGLNNLAKLGLSFNSISA--VDNGSLANTPHLRELHLDNNKLTRVPGG 287
Query: 425 L 425
L
Sbjct: 288 L 288
Score = 84.3 bits (207), Expect = 2e-16
Identities = 56/204 (27%), Positives = 95/204 (46%), Gaps = 2/204 (0%)
Query: 266 LEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSG 325
L + S L VP LP +L L N+I +++ + L L+L +N++ S
Sbjct: 62 LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKI--SK 119
Query: 326 LPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTEL 385
+ GA PL L L+L N L +P +P+ L+ L N + + + +
Sbjct: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
Query: 386 NLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPE 445
L N L S+ + + AF+ ++ L + +A +T +P GLP L L L N++ ++
Sbjct: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
Query: 446 PLAGLDQLRELSLAHNRLRVGDIG 469
L GL+ L +L L+ N + D G
Sbjct: 240 SLKGLNNLAKLGLSFNSISAVDNG 263
Score = 53.9 bits (128), Expect = 3e-07
Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 2/134 (1%)
Query: 346 GLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRL 405
GLD+VP LP L L +N + + D L L L N+++ +V AF L
Sbjct: 71 GLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKIS--KVSPGAFTPL 128
Query: 406 RALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 465
L L L+ NQL LP +P L+ L+ N++ + GL+Q+ + L N L+
Sbjct: 129 VKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKS 188
Query: 466 GDIGPGTWHELQAL 479
I G + ++ L
Sbjct: 189 SGIENGAFQGMKKL 202
>gi|38202222 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 122 bits (307), Expect = 6e-28
Identities = 86/256 (33%), Positives = 120/256 (46%), Gaps = 28/256 (10%)
Query: 171 SVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVP 230
++YL NNQ++NAG+P D + + + L +N L P +LP ++ LHLQ N I +
Sbjct: 62 TLYLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT 120
Query: 231 RGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAIL 290
+LS+ L EL+L N ++ ++ F + L L LS N L+T+P GLPRT+ L
Sbjct: 121 YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL 180
Query: 291 HLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRV 350
L NRI + + L G L+ L+L N L + GL L L L L N L
Sbjct: 181 RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA 240
Query: 351 PPALP-RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALR 409
P LP LR L L NH+ RV AF LR L
Sbjct: 241 PVNLPGTNLRKLYLQDNHI--------------------------NRVPPNAFSYLRQLY 274
Query: 410 SLDLAGNQLTRLPMGL 425
LD++ N L+ LP G+
Sbjct: 275 RLDMSNNNLSNLPQGI 290
Score = 113 bits (283), Expect = 4e-25
Identities = 93/310 (30%), Positives = 135/310 (43%), Gaps = 29/310 (9%)
Query: 37 LQPLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLS 96
L + ++CP C C + C+ L P I A L LQNNQ
Sbjct: 24 LSVMAKSCPSVCRCD-AGFIYCNDRFLTSIPTGIPEDATTLYLQNNQ------------- 69
Query: 97 GLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVM 156
I++ G+P + ++L +++ + + HN L P LP+ ++ L N +
Sbjct: 70 -----------INNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIR 117
Query: 157 EIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSL 216
I + + P L ++L +N +S + AFR S + L LS N LS +P LP ++
Sbjct: 118 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTI 177
Query: 217 ERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQL 276
E L L +N IS + +L T L+ L L N L + GL F L +L L L N L
Sbjct: 178 EELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSL 237
Query: 277 TTVPAGLPRT-LAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLR 335
T P LP T L L+L N I +V R L L + +N L S LP G L
Sbjct: 238 TAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNL--SNLPQGIFDDLD 295
Query: 336 GLHTLHLYGN 345
+ L L N
Sbjct: 296 NITQLILRNN 305
Score = 104 bits (260), Expect = 2e-22
Identities = 76/246 (30%), Positives = 112/246 (45%), Gaps = 5/246 (2%)
Query: 219 LHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTT 278
++ + ++ +P G T L YLQ+NQ+ ++G+ + L +E + L HN L
Sbjct: 42 IYCNDRFLTSIPTGIPEDATTL---YLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDE 97
Query: 279 VPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLH 338
P LP+ + LHL N IR + L L L L N + + + GA R L
Sbjct: 98 FPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLR 157
Query: 339 TLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVH 398
L L N L +P LPR + L L N ++ + + L L L L N L + +
Sbjct: 158 LLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLG 217
Query: 399 HRAFRRLRALRSLDLAGNQLTRLPMGLP-TGLRTLQLQRNQLRMLEPEPLAGLDQLRELS 457
+ F L L L L N LT P+ LP T LR L LQ N + + P + L QL L
Sbjct: 218 DKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLD 277
Query: 458 LAHNRL 463
+++N L
Sbjct: 278 MSNNNL 283
Score = 86.7 bits (213), Expect = 5e-17
Identities = 58/181 (32%), Positives = 93/181 (51%), Gaps = 2/181 (1%)
Query: 314 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGA 373
L LQ+NQ+ ++G+P+ L+ L + ++LY N LD P LP+ ++ L L N++ +
Sbjct: 63 LYLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITY 121
Query: 374 RDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ 433
L P L EL+L N +++ + AFR LR L L+ N L+ +P GLP + L+
Sbjct: 122 DSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELR 181
Query: 434 LQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSHTVPRA 493
L N++ + L GL L+ L L N L +G + L L LV +++ A
Sbjct: 182 LDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNL-TELSLVRNSLTAA 240
Query: 494 P 494
P
Sbjct: 241 P 241
>gi|7019383 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 122 bits (307), Expect = 6e-28
Identities = 86/256 (33%), Positives = 120/256 (46%), Gaps = 28/256 (10%)
Query: 171 SVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVP 230
++YL NNQ++NAG+P D + + + L +N L P +LP ++ LHLQ N I +
Sbjct: 62 TLYLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT 120
Query: 231 RGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAIL 290
+LS+ L EL+L N ++ ++ F + L L LS N L+T+P GLPRT+ L
Sbjct: 121 YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL 180
Query: 291 HLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRV 350
L NRI + + L G L+ L+L N L + GL L L L L N L
Sbjct: 181 RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA 240
Query: 351 PPALP-RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALR 409
P LP LR L L NH+ RV AF LR L
Sbjct: 241 PVNLPGTNLRKLYLQDNHI--------------------------NRVPPNAFSYLRQLY 274
Query: 410 SLDLAGNQLTRLPMGL 425
LD++ N L+ LP G+
Sbjct: 275 RLDMSNNNLSNLPQGI 290
Score = 113 bits (283), Expect = 4e-25
Identities = 93/310 (30%), Positives = 135/310 (43%), Gaps = 29/310 (9%)
Query: 37 LQPLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLS 96
L + ++CP C C + C+ L P I A L LQNNQ
Sbjct: 24 LSVMAKSCPSVCRCD-AGFIYCNDRFLTSIPTGIPEDATTLYLQNNQ------------- 69
Query: 97 GLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVM 156
I++ G+P + ++L +++ + + HN L P LP+ ++ L N +
Sbjct: 70 -----------INNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIR 117
Query: 157 EIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSL 216
I + + P L ++L +N +S + AFR S + L LS N LS +P LP ++
Sbjct: 118 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTI 177
Query: 217 ERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQL 276
E L L +N IS + +L T L+ L L N L + GL F L +L L L N L
Sbjct: 178 EELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSL 237
Query: 277 TTVPAGLPRT-LAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLR 335
T P LP T L L+L N I +V R L L + +N L S LP G L
Sbjct: 238 TAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNL--SNLPQGIFDDLD 295
Query: 336 GLHTLHLYGN 345
+ L L N
Sbjct: 296 NITQLILRNN 305
Score = 104 bits (260), Expect = 2e-22
Identities = 76/246 (30%), Positives = 112/246 (45%), Gaps = 5/246 (2%)
Query: 219 LHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTT 278
++ + ++ +P G T L YLQ+NQ+ ++G+ + L +E + L HN L
Sbjct: 42 IYCNDRFLTSIPTGIPEDATTL---YLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDE 97
Query: 279 VPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLH 338
P LP+ + LHL N IR + L L L L N + + + GA R L
Sbjct: 98 FPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLR 157
Query: 339 TLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVH 398
L L N L +P LPR + L L N ++ + + L L L L N L + +
Sbjct: 158 LLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLG 217
Query: 399 HRAFRRLRALRSLDLAGNQLTRLPMGLP-TGLRTLQLQRNQLRMLEPEPLAGLDQLRELS 457
+ F L L L L N LT P+ LP T LR L LQ N + + P + L QL L
Sbjct: 218 DKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLD 277
Query: 458 LAHNRL 463
+++N L
Sbjct: 278 MSNNNL 283
Score = 86.7 bits (213), Expect = 5e-17
Identities = 58/181 (32%), Positives = 93/181 (51%), Gaps = 2/181 (1%)
Query: 314 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGA 373
L LQ+NQ+ ++G+P+ L+ L + ++LY N LD P LP+ ++ L L N++ +
Sbjct: 63 LYLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITY 121
Query: 374 RDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ 433
L P L EL+L N +++ + AFR LR L L+ N L+ +P GLP + L+
Sbjct: 122 DSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELR 181
Query: 434 LQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSHTVPRA 493
L N++ + L GL L+ L L N L +G + L L LV +++ A
Sbjct: 182 LDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNL-TELSLVRNSLTAA 240
Query: 494 P 494
P
Sbjct: 241 P 241
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 121 bits (304), Expect = 1e-27
Identities = 118/370 (31%), Positives = 164/370 (44%), Gaps = 43/370 (11%)
Query: 36 SLQPLPR-ACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQH----LSLQNNQLQELPYN 90
+L PL CP RC C + C LRV P + + H SL N + +
Sbjct: 18 ALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAF 77
Query: 91 ELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADL 150
+ RL LR L+L N I S L + FE L++L+ L + +N L
Sbjct: 78 DFHRLGQLRRLDLQYNQIRS--LHPKTFEKLSRLEELYLGNNLLQA-------------- 121
Query: 151 AANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPP 210
+ P T LR +Y + N++S L +F G E++ L L N L LP
Sbjct: 122 -------LAPGTLAPLRKLRILYANGNEISR--LSRGSFEGLESLVKLRLDGNALGALPD 172
Query: 211 SLPPSLERL---HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLE 267
++ L L HL++N I + + A ++ +LR L L N+L S A TF+ L SL
Sbjct: 173 AVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLS 232
Query: 268 YLDLSHNQL----TTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGS 323
L LS N L + LPR L +L L N++ + G LR L L+ N+L
Sbjct: 233 SLILSANNLQHLGPRIFQHLPR-LGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRL-- 289
Query: 324 SGLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATP 380
S LP L PL L L L GN L + PA RLR L L +N ++AL A+P
Sbjct: 290 SQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASP 349
Query: 381 GLTELNLAYN 390
L L+L N
Sbjct: 350 ALYRLDLDGN 359
Score = 96.7 bits (239), Expect = 5e-20
Identities = 111/356 (31%), Positives = 147/356 (41%), Gaps = 60/356 (16%)
Query: 125 QHLCVAHNKLSVAPQFL----PRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLS 180
QHL + L V P+ P + L N + I F LR + L NQ+
Sbjct: 37 QHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIR 96
Query: 181 NAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQL 240
+ L P F +LS LE L+L NNL+ + G L+ +L
Sbjct: 97 S--LHPKTFE-------------KLS--------RLEELYLGNNLLQALAPGTLAPLRKL 133
Query: 241 RELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLA---ILHLGRNRI 297
R LY N++ S L +F L SL L L N L +P + L LHL NRI
Sbjct: 134 RILYANGNEI--SRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRI 191
Query: 298 RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR 357
R + LR+L L N+L S A PLR L +L L N L + P + +
Sbjct: 192 RFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQH 251
Query: 358 LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ 417
L P L L+L N+L + AF L ALR L L GN+
Sbjct: 252 L---------------------PRLGLLSLRGNQLT--HLAPEAFWGLEALRELRLEGNR 288
Query: 418 LTRLPMGLPTGLRTLQ---LQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV--GDI 468
L++LP L L +L+ L N+L L P L +LRELSL +N L GDI
Sbjct: 289 LSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDI 344
Score = 38.5 bits (88), Expect = 0.015
Identities = 22/53 (41%), Positives = 31/53 (58%), Gaps = 2/53 (3%)
Query: 429 LRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQV 481
LR L LQ NQ+R L P+ L +L EL L +N L+ + PGT L+ L++
Sbjct: 85 LRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQA--LAPGTLAPLRKLRI 135
>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
sapiens]
Length = 674
Score = 120 bits (302), Expect = 2e-27
Identities = 84/256 (32%), Positives = 123/256 (48%), Gaps = 28/256 (10%)
Query: 171 SVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVP 230
++YL NNQ++NAG+P D + + + L N L P +LP SL LHLQ+N + +
Sbjct: 85 TLYLQNNQINNAGIPQD-LKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIA 143
Query: 231 RGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAIL 290
R +L+R L +L+L N ++ ++ F+ L+ L LS N L+++P+GLP TL L
Sbjct: 144 RDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEEL 203
Query: 291 HLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRV 350
L NRI + G LR L+L N L + + L+ L L L N L
Sbjct: 204 RLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAP 263
Query: 351 PPALP-RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALR 409
P LP L+ L L N ++ ++ YN LA ++R L
Sbjct: 264 PLNLPSAHLQKLYLQDNAIS----------------HIPYNTLA----------KMRELE 297
Query: 410 SLDLAGNQLTRLPMGL 425
LDL+ N LT LP GL
Sbjct: 298 RLDLSNNNLTTLPRGL 313
Score = 115 bits (287), Expect = 1e-25
Identities = 87/247 (35%), Positives = 116/247 (46%), Gaps = 4/247 (1%)
Query: 100 TLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIF 159
TL L NN I++ G+P + ++ +Q + + N L P LPRSLR L N V I
Sbjct: 85 TLYLQNNQINNAGIPQD-LKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIA 143
Query: 160 PLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERL 219
+ P L ++L +N +S + DAF S+ + L LS N LS +P LP +LE L
Sbjct: 144 RDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEEL 203
Query: 220 HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTV 279
L +N IS +P A LR L L N L + + TFS+L +L L L N L
Sbjct: 204 RLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAP 263
Query: 280 PAGLPRT-LAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLH 338
P LP L L+L N I + L R L L L +N L + LP G L L
Sbjct: 264 PLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNL--TTLPRGLFDDLGNLA 321
Query: 339 TLHLYGN 345
L L N
Sbjct: 322 QLLLRNN 328
Score = 104 bits (259), Expect = 2e-22
Identities = 71/214 (33%), Positives = 114/214 (53%), Gaps = 3/214 (1%)
Query: 62 DLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESL 121
DL FP N+ R+ + L LQ+N ++ + + L+R+ L L+L +N +S+ + ++AF
Sbjct: 117 DLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADS 176
Query: 122 TQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSN 181
QL+ L ++ N LS P LP +L L N++ I F +LR + L N L+N
Sbjct: 177 KQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLAN 236
Query: 182 AGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPS-LERLHLQNNLISKVPRGALSRQTQL 240
+ D F + + LSL N L+ P +LP + L++L+LQ+N IS +P L++ +L
Sbjct: 237 QRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMREL 296
Query: 241 RELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHN 274
L L +N LT L F L +L L L +N
Sbjct: 297 ERLDLSNNNLTT--LPRGLFDDLGNLAQLLLRNN 328
Score = 94.7 bits (234), Expect = 2e-19
Identities = 69/222 (31%), Positives = 103/222 (46%), Gaps = 2/222 (0%)
Query: 243 LYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEA 302
LYLQ+NQ+ ++G+ +K++ ++ + L N L P LPR+L LHL N +R +
Sbjct: 86 LYLQNNQINNAGIPQDLKTKVN-VQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIAR 144
Query: 303 ARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV 362
L L L L N + + + A + L L L N L +P LP L L
Sbjct: 145 DSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELR 204
Query: 363 LPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLP 422
L N ++ + L L L N LA+ R+ F RL+ L L L N L P
Sbjct: 205 LDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPP 264
Query: 423 MGLPTG-LRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRL 463
+ LP+ L+ L LQ N + + LA + +L L L++N L
Sbjct: 265 LNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNL 306
Score = 86.7 bits (213), Expect = 5e-17
Identities = 57/166 (34%), Positives = 85/166 (51%), Gaps = 1/166 (0%)
Query: 314 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGA 373
L LQ+NQ+ ++G+P L+ + ++LY N LD P LPR LR L L N+V +
Sbjct: 86 LYLQNNQINNAGIPQD-LKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIAR 144
Query: 374 RDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ 433
L P L +L+L N +++ + AF + L+ L L+ N L+ +P GLP L L+
Sbjct: 145 DSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELR 204
Query: 434 LQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQAL 479
L N++ + GL+ LR L L N L I T+ LQ L
Sbjct: 205 LDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNL 250
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 120 bits (301), Expect = 3e-27
Identities = 127/416 (30%), Positives = 186/416 (44%), Gaps = 50/416 (12%)
Query: 41 PRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRT 100
P+ACP +CSC TVDC GL LR P NI R + L L N + + + + L LR
Sbjct: 25 PQACPAQCSCSG-STVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRV 83
Query: 101 LNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFL---PRSLRVADLAANQVME 157
L L N IS+ + AF+ L +L+ L + N L + P+ L L DL+ NQ+
Sbjct: 84 LQLMENKIST--IERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQA 141
Query: 158 IFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PP 214
I F ++++ L NQ+S + AFR + L+L+NN ++ L + P
Sbjct: 142 IPRKAFRGAVDIKNLQLDYNQIS--CIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMP 199
Query: 215 SLE--RLHLQNNLISKVPRGALS---RQTQLRELYLQ---------HN-------QLTDS 253
L RLH NNL LS RQ LY Q HN + S
Sbjct: 200 KLRTFRLH-SNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCS 258
Query: 254 G---LDATTFSKLH-------SLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAA 303
G A + S LH S +D LT +P LP T+ + L +N I+ +
Sbjct: 259 GHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPG 318
Query: 304 RLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPR---RLRA 360
+ LR + L +NQ+ S L A + LR L++L LYGN + +P +L L+
Sbjct: 319 AFSPYKKLRRIDLSNNQI--SELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQL 376
Query: 361 LVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGN 416
L+L N + L L L+L N+L + + F LRA++++ LA N
Sbjct: 377 LLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQT--IAKGTFSPLRAIQTMHLAQN 430
Score = 95.5 bits (236), Expect = 1e-19
Identities = 102/394 (25%), Positives = 160/394 (40%), Gaps = 57/394 (14%)
Query: 134 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 193
L P+ +PR+ DL N + I F LR + L N++S + AF+ +
Sbjct: 46 LRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKIST--IERGAFQDLK 103
Query: 194 AIATLSLSNNQLSYLPPSL---PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQL 250
+ L L+ N L P L L RL L N I +PR A ++ L L +NQ+
Sbjct: 104 ELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQI 163
Query: 251 TDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARG 310
S ++ F L LE L L++N +T + + H+ + R ++ + L+
Sbjct: 164 --SCIEDGAFRALRDLEVLTLNNNNITRLSVA-----SFNHMPKLRTFRLHSNNLYCDCH 216
Query: 311 LRYLLLQHNQLGSSGLPAGALRP--LRGLHTLHLY------------------------- 343
L +L Q GL + P LRG + +
Sbjct: 217 LAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAA 276
Query: 344 -----------GNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRL 392
G GL +P LP + + L N + + L ++L+ N++
Sbjct: 277 CTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQI 336
Query: 393 ASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ---LQRNQLRMLEPEPLAG 449
+ AF+ LR+L SL L GN++T LP L GL +LQ L N++ L +
Sbjct: 337 SELAPD--AFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQD 394
Query: 450 LDQLRELSLAHNRLRVGDIGPGTWHELQALQVRH 483
L L LSL N+L+ I GT+ L+A+Q H
Sbjct: 395 LHNLNLLSLYDNKLQT--IAKGTFSPLRAIQTMH 426
Score = 77.0 bits (188), Expect = 4e-14
Identities = 139/606 (22%), Positives = 214/606 (35%), Gaps = 166/606 (27%)
Query: 44 CPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNL 103
CP C+C + VDC G L P N+ + L+ N ++ +P S LR ++L
Sbjct: 273 CPAACTCSN-NIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDL 331
Query: 104 HNNLISSEG----------------------LPDEAFESLTQLQHLCVAHNKLSV----A 137
NN IS LP FE L LQ L + NK++ A
Sbjct: 332 SNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDA 391
Query: 138 PQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSV------------------YLHNNQL 179
Q L +L + L N++ I TF A++++ YLH N +
Sbjct: 392 FQDL-HNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPI 450
Query: 180 SNAG----------------LPPDAFR----------GSEAI------------------ 195
+G + FR G+E
Sbjct: 451 ETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKC 510
Query: 196 ----ATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPR-GALSRQTQLRELYLQHNQL 250
T+ SN +L+ +P +P L L NN + + G + QLR++ +N++
Sbjct: 511 RCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKI 570
Query: 251 TDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPR---TLAILHLGRNRIRQVEAARLHG 307
TD ++ F + + L+ N+L V + + +L L L NRI V G
Sbjct: 571 TD--IEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIG 628
Query: 308 ARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLD---------------RVPP 352
+R L L NQ+ + + GA L L TL+L N + R+
Sbjct: 629 LSSVRLLSLYDNQITT--VAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVT 686
Query: 353 ALPRRLRALVLPHNHVAALGARDLVATPGLTELNLA-YNRLAS--------ARVHHRAFR 403
PR + L + + +D G + + + +R + R ++ +
Sbjct: 687 GNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLK 746
Query: 404 RL-----RALRSLDLAGNQLTRLPMGLP--------------------------TGLRTL 432
L R + L L GNQ T +P L T L TL
Sbjct: 747 VLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTL 806
Query: 433 QLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSHTVPR 492
L N+LR + P GL LR LSL N + V + G +++L AL SH
Sbjct: 807 ILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISV--VPEGAFNDLSAL-------SHLAIG 857
Query: 493 APPSPC 498
A P C
Sbjct: 858 ANPLYC 863
Score = 71.6 bits (174), Expect = 2e-12
Identities = 95/389 (24%), Positives = 160/389 (41%), Gaps = 76/389 (19%)
Query: 22 VAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQN 81
+ G ED G+ L ACP +C C TVDC L P++I + L L N
Sbjct: 486 IPGTEDYRSKLSGDCFADL--ACPEKCRCEGT-TVDCSNQKLNKIPEHIPQYTAELRLNN 542
Query: 82 NQLQELPYNEL-SRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQF 140
N+ L + +L LR +N NN I+ + + AFE + + + + N+L
Sbjct: 543 NEFTVLEATGIFKKLPQLRKINFSNNKITD--IEEGAFEGASGVNEILLTSNRLENVQHK 600
Query: 141 LPR---SLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIAT 197
+ + SL+ L +N++ + +F ++R + L++NQ++ + P AF +++T
Sbjct: 601 MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITT--VAPGAFDTLHSLST 658
Query: 198 LSL------SNNQLSYLPPSL--------------PPSLERLHLQN-------------- 223
L+L N L++L L P L+ + +Q+
Sbjct: 659 LNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDD 718
Query: 224 ---NLISKVPRGALSRQTQLR------------------ELYLQHNQLTDSGLDATTFSK 262
+ +S+ P T +R ELYL NQ T L S
Sbjct: 719 NSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFT---LVPKELSN 775
Query: 263 LHSLEYLDLSHNQLTTVP----AGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQH 318
L +DLS+N+++T+ + + + L ++ L NR+R + G + LR L L
Sbjct: 776 YKHLTLIDLSNNRISTLSNQSFSNMTQLLTLI-LSYNRLRCIPPRTFDGLKSLRLLSLHG 834
Query: 319 NQLGSSGLPAGALRPLRGLHTLHLYGNGL 347
N + S +P GA L L L + N L
Sbjct: 835 NDI--SVVPEGAFNDLSALSHLAIGANPL 861
Score = 39.3 bits (90), Expect = 0.009
Identities = 37/152 (24%), Positives = 60/152 (39%), Gaps = 29/152 (19%)
Query: 339 TLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVH 398
T+ +G L VP +PR L L N++ + D L L L N++++ +
Sbjct: 38 TVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKIST--IE 95
Query: 399 HRAFRRLRALRSL------------------------DLAGNQLTRLPMGLPTG---LRT 431
AF+ L+ L L DL+ NQ+ +P G ++
Sbjct: 96 RGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKN 155
Query: 432 LQLQRNQLRMLEPEPLAGLDQLRELSLAHNRL 463
LQL NQ+ +E L L L+L +N +
Sbjct: 156 LQLDYNQISCIEDGAFRALRDLEVLTLNNNNI 187
>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
sapiens]
Length = 660
Score = 120 bits (301), Expect = 3e-27
Identities = 83/262 (31%), Positives = 123/262 (46%), Gaps = 26/262 (9%)
Query: 172 VYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPR 231
+YLHNNQ++NAG P + +++ T+ L NQL P +LP ++ LHLQ N I + R
Sbjct: 68 LYLHNNQINNAGFPAE-LHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR 126
Query: 232 GALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILH 291
AL++ +L EL+L N ++ G++ F + SL+ L LS N L++VP GLP L L
Sbjct: 127 AALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR 186
Query: 292 LGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVP 351
+ NRI + L L++ N L + G+ G L L + N L P
Sbjct: 187 VDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
Query: 352 PALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSL 411
P LP H+ L +D ++N + AF LR L L
Sbjct: 247 PDLPG---------THLIRLYLQD-------NQIN---------HIPLTAFSNLRKLERL 281
Query: 412 DLAGNQLTRLPMGLPTGLRTLQ 433
D++ NQL L G+ L L+
Sbjct: 282 DISNNQLRMLTQGVFDNLSNLK 303
Score = 107 bits (266), Expect = 3e-23
Identities = 82/280 (29%), Positives = 122/280 (43%), Gaps = 27/280 (9%)
Query: 43 ACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLN 102
ACP C C R + V C+ L P I G+ L
Sbjct: 35 ACPSVCRCDR-NFVYCNERSLTSVPLGIPE------------------------GVTVLY 69
Query: 103 LHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLT 162
LHNN I++ G P E ++ + + + N+L P LP+++RV L N + I
Sbjct: 70 LHNNQINNAGFPAE-LHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAA 128
Query: 163 FGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQ 222
+ L ++L +N +S G+ AFR + ++ L LS N LS +P LP L+ L +
Sbjct: 129 LAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVD 188
Query: 223 NNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAG 282
N I+ + A T L L + N LT+ G+ TFS L L+ + N L+ P
Sbjct: 189 ENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPD 248
Query: 283 LPRT-LAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQL 321
LP T L L+L N+I + R L L + +NQL
Sbjct: 249 LPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQL 288
Score = 96.7 bits (239), Expect = 5e-20
Identities = 65/201 (32%), Positives = 103/201 (51%), Gaps = 6/201 (2%)
Query: 298 RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR 357
R + + L G+ L L +NQ+ ++G PA L ++ +HT++LYGN LD P LP+
Sbjct: 52 RSLTSVPLGIPEGVTVLYLHNNQINNAGFPA-ELHNVQSVHTVYLYGNQLDEFPMNLPKN 110
Query: 358 LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ 417
+R L L N++ + L L EL+L N +++ V AFR +L+ L L+ N
Sbjct: 111 VRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNH 170
Query: 418 LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ 477
L+ +P+GLP L+ L++ N++ ++ L L L + N L I GT+ L
Sbjct: 171 LSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLT 230
Query: 478 ALQ----VRHRLVSHTVPRAP 494
L+ VR+ L SH P P
Sbjct: 231 KLKEFSIVRNSL-SHPPPDLP 250
Score = 93.6 bits (231), Expect = 4e-19
Identities = 68/224 (30%), Positives = 103/224 (45%), Gaps = 2/224 (0%)
Query: 243 LYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEA 302
LYL +NQ+ ++G A + + S+ + L NQL P LP+ + +LHL N I+ +
Sbjct: 68 LYLHNNQINNAGFPAELHN-VQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR 126
Query: 303 ARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV 362
A L L L L N + + G+ GA R L L L N L VP LP L+ L
Sbjct: 127 AALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR 186
Query: 363 LPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLP 422
+ N +A + L L + N L + + F L L+ + N L+ P
Sbjct: 187 VDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
Query: 423 MGLP-TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 465
LP T L L LQ NQ+ + + L +L L +++N+LR+
Sbjct: 247 PDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRM 290
Score = 83.2 bits (204), Expect = 5e-16
Identities = 61/221 (27%), Positives = 98/221 (44%), Gaps = 25/221 (11%)
Query: 53 VDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEG 112
V TV G L FP N+ + + L LQ N +Q + L++L L L+L +N IS+ G
Sbjct: 90 VHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVG 149
Query: 113 LPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSV 172
+ D AF L+ L ++ N LS P LP L+ + N++ I + F +L +
Sbjct: 150 VEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERL 209
Query: 173 YLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPS----------------- 215
+ N L+N G+ F + S+ N LS+ PP LP +
Sbjct: 210 IVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPL 269
Query: 216 --------LERLHLQNNLISKVPRGALSRQTQLRELYLQHN 248
LERL + NN + + +G + L++L ++N
Sbjct: 270 TAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNN 310
Score = 36.6 bits (83), Expect = 0.056
Identities = 36/149 (24%), Positives = 62/149 (41%), Gaps = 20/149 (13%)
Query: 77 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNK--- 133
L LQ+NQ+ +P S L L L++ NN + L F++L+ L+ L +N
Sbjct: 257 LYLQDNQINHIPLTAFSNLRKLERLDISNNQLRM--LTQGVFDNLSNLKQLTARNNPWFC 314
Query: 134 ------LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLP-- 185
++ +++P SL V ++ + E ++ L + + GLP
Sbjct: 315 DCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVREL----NMNLLSCPTTTPGLPLF 370
Query: 186 ---PDAFRGSEAIATLSLSNNQLSYLPPS 211
P + TLS+ N SY PP+
Sbjct: 371 TPAPSTASPTTQPPTLSIPNPSRSYTPPT 399
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 120 bits (300), Expect = 4e-27
Identities = 113/370 (30%), Positives = 167/370 (45%), Gaps = 44/370 (11%)
Query: 77 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 136
L LQNNQL +P L L L++L L NLIS +P+ +FE L+ L+HL + N L+
Sbjct: 67 LMLQNNQLGGIPAEALWELPSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTE 124
Query: 137 AP----QFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGS 192
P LP +L+ LA N++ I F +L ++LHNN++ + G +F G
Sbjct: 125 IPVRALNNLP-ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGT--HSFEGL 181
Query: 193 EAIATLSLSNNQLSYLPPSLPP--SLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQL 250
+ TL L+ N+L P ++ L+ L NN I +P A L+ ++ N +
Sbjct: 182 HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 241
Query: 251 TDSGLDATTF-SKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGAR 309
G A + KLH+L Q E L G
Sbjct: 242 QFVGRSAFQYLPKLHTLSLNGAMDIQ-------------------------EFPDLKGTT 276
Query: 310 GLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPR--RLRALVLPHNH 367
L L L + G LP+G + L L L L N ++ +P +L R +L + L HN
Sbjct: 277 SLEILTL--TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNR 333
Query: 368 VAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPT 427
+ +GA L L+L++N + S +H AF L +L LDL NQLT LP+
Sbjct: 334 IWEIGADTFSQLSSLQALDLSWNAIRS--IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLG 391
Query: 428 GLRTLQLQRN 437
GL L+L+ N
Sbjct: 392 GLMHLKLKGN 401
Score = 97.8 bits (242), Expect = 2e-20
Identities = 105/370 (28%), Positives = 158/370 (42%), Gaps = 62/370 (16%)
Query: 149 DLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYL 208
DL+ N + E+ P F L + L N LS+ +P AF G ++ L L NNQL +
Sbjct: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSH--IPGQAFSGLYSLKILMLQNNQLGGI 77
Query: 209 PPSLP---PSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHS 265
P PSL+ L L NLIS VP + + LR L+L N LT+ + + L +
Sbjct: 78 PAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTE--IPVRALNNLPA 135
Query: 266 LEYLDLSHNQLTTVPAGLPR---TLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLG 322
L+ + L+ N+++ +P + +L +LHL NRI+ + G L L L +N+L
Sbjct: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
Query: 323 SSGLPAGALRPLRGLHTLHLYGNGLDRVP-------PALPR------------RLRALVL 363
+ A+R L L L + N + +P P L R L
Sbjct: 196 EFPV---AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL 252
Query: 364 PHNHVAAL-GARDLVATP---GLTELNLAYNRLASARVHHRAF-RRLRALRSLDLAGNQL 418
P H +L GA D+ P G T L + A R+ ++L LR L+L+ NQ+
Sbjct: 253 PKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 312
Query: 419 TRLP----------MGLP---------------TGLRTLQLQRNQLRMLEPEPLAGLDQL 453
LP +GL + L+ L L N +R + PE + L L
Sbjct: 313 EELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSL 372
Query: 454 RELSLAHNRL 463
+L L N+L
Sbjct: 373 VKLDLTDNQL 382
Score = 85.9 bits (211), Expect = 8e-17
Identities = 99/347 (28%), Positives = 146/347 (42%), Gaps = 53/347 (15%)
Query: 75 QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKL 134
+HL L +N L E+P L+ L L+ + L N IS +PD AF++LT L L + +N++
Sbjct: 113 RHLWLDDNALTEIPVRALNNLPALQAMTLALNRISH--IPDYAFQNLTSLVVLHLHNNRI 170
Query: 135 SVAPQFL---PRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRG 191
+L DL N++ E FP+ L+ + HNN + +P AF G
Sbjct: 171 QHLGTHSFEGLHNLETLDLNYNKLQE-FPVAIRTLGRLQELGFHNNNIK--AIPEKAFMG 227
Query: 192 SEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLT 251
+ P L+ +H +N I V R A +L L L
Sbjct: 228 N---------------------PLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL------ 260
Query: 252 DSGLDATTFSKLH---SLEYLDLSHNQLTTVPAG----LPRTLAILHLGRNRIRQVEAAR 304
+ +D F L SLE L L+ + +P+G LPR L +L L N+I ++ +
Sbjct: 261 NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELPS-- 317
Query: 305 LHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV-- 362
LH + L + LQHN++ G A L L L L N + + P L +LV
Sbjct: 318 LHRCQKLEEIGLQHNRIWEIG--ADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 375
Query: 363 -LPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRAL 408
L N + L L GL L L N S +F +LR L
Sbjct: 376 DLTDNQLTTL---PLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRIL 419
Score = 71.6 bits (174), Expect = 2e-12
Identities = 68/204 (33%), Positives = 95/204 (46%), Gaps = 14/204 (6%)
Query: 270 DLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGL 326
DLS N LT + GL R L L L N + + G L+ L+LQ+NQLG G+
Sbjct: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG--GI 77
Query: 327 PAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATPGLT 383
PA AL L L +L L N + VP LR L L N + + R L P L
Sbjct: 78 PAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQ 137
Query: 384 ELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTG---LRTLQLQRNQLR 440
+ LA NR+ + + AF+ L +L L L N++ L G L TL L N+L+
Sbjct: 138 AMTLALNRI--SHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
Query: 441 MLEPEPLAGLDQLRELSLAHNRLR 464
P + L +L+EL +N ++
Sbjct: 196 EF-PVAIRTLGRLQELGFHNNNIK 218
Score = 44.3 bits (103), Expect = 3e-04
Identities = 55/220 (25%), Positives = 97/220 (44%), Gaps = 35/220 (15%)
Query: 51 PRVDTVDCDG-LDLRVFPD-NITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLI 108
P++ T+ +G +D++ FPD T + + L+L ++ LP +L LR L L +N I
Sbjct: 253 PKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 312
Query: 109 SSEGLPDEAFESLTQLQHLCVAHNKL-SVAPQFLPR--SLRVADLAANQVMEIFPLTFGE 165
E LP + +L+ + + HN++ + + SL+ DL+ N + I P F
Sbjct: 313 --EELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 368
Query: 166 KPALRSVYLHNNQLSN------AGLPPDAFRGSEAIATLSLSNN-------QLSYLPPSL 212
+L + L +NQL+ GL +G+ A++ ++ ++ Y
Sbjct: 369 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC 428
Query: 213 PPSL-------------ERLHLQNNLISKVPRGALSRQTQ 239
P + E LHL + SK P G L+RQ +
Sbjct: 429 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAE 468
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 120 bits (300), Expect = 4e-27
Identities = 113/370 (30%), Positives = 167/370 (45%), Gaps = 44/370 (11%)
Query: 77 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 136
L LQNNQL +P L L L++L L NLIS +P+ +FE L+ L+HL + N L+
Sbjct: 119 LMLQNNQLGGIPAEALWELPSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTE 176
Query: 137 AP----QFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGS 192
P LP +L+ LA N++ I F +L ++LHNN++ + G +F G
Sbjct: 177 IPVRALNNLP-ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGT--HSFEGL 233
Query: 193 EAIATLSLSNNQLSYLPPSLPP--SLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQL 250
+ TL L+ N+L P ++ L+ L NN I +P A L+ ++ N +
Sbjct: 234 HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 293
Query: 251 TDSGLDATTF-SKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGAR 309
G A + KLH+L Q E L G
Sbjct: 294 QFVGRSAFQYLPKLHTLSLNGAMDIQ-------------------------EFPDLKGTT 328
Query: 310 GLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPR--RLRALVLPHNH 367
L L L + G LP+G + L L L L N ++ +P +L R +L + L HN
Sbjct: 329 SLEILTL--TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNR 385
Query: 368 VAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPT 427
+ +GA L L+L++N + S +H AF L +L LDL NQLT LP+
Sbjct: 386 IWEIGADTFSQLSSLQALDLSWNAIRS--IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLG 443
Query: 428 GLRTLQLQRN 437
GL L+L+ N
Sbjct: 444 GLMHLKLKGN 453
Score = 99.8 bits (247), Expect = 5e-21
Identities = 109/385 (28%), Positives = 162/385 (42%), Gaps = 62/385 (16%)
Query: 134 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 193
LS P L DL+ N + E+ P F L + L N LS+ +P AF G
Sbjct: 57 LSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSH--IPGQAFSGLY 114
Query: 194 AIATLSLSNNQLSYLPPSLP---PSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQL 250
++ L L NNQL +P PSL+ L L NLIS VP + + LR L+L N L
Sbjct: 115 SLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNAL 174
Query: 251 TDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPR---TLAILHLGRNRIRQVEAARLHG 307
T+ + + L +L+ + L+ N+++ +P + +L +LHL NRI+ + G
Sbjct: 175 TE--IPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEG 232
Query: 308 ARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVP-------PALPR---- 356
L L L +N+L + A+R L L L + N + +P P L
Sbjct: 233 LHNLETLDLNYNKLQEFPV---AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFY 289
Query: 357 --------RLRALVLPHNHVAAL-GARDLVATP---GLTELNLAYNRLASARVHHRAF-R 403
R LP H +L GA D+ P G T L + A R+ +
Sbjct: 290 DNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQ 349
Query: 404 RLRALRSLDLAGNQLTRLP----------MGLP---------------TGLRTLQLQRNQ 438
+L LR L+L+ NQ+ LP +GL + L+ L L N
Sbjct: 350 QLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNA 409
Query: 439 LRMLEPEPLAGLDQLRELSLAHNRL 463
+R + PE + L L +L L N+L
Sbjct: 410 IRSIHPEAFSTLHSLVKLDLTDNQL 434
Score = 85.9 bits (211), Expect = 8e-17
Identities = 99/347 (28%), Positives = 146/347 (42%), Gaps = 53/347 (15%)
Query: 75 QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKL 134
+HL L +N L E+P L+ L L+ + L N IS +PD AF++LT L L + +N++
Sbjct: 165 RHLWLDDNALTEIPVRALNNLPALQAMTLALNRISH--IPDYAFQNLTSLVVLHLHNNRI 222
Query: 135 SVAPQFL---PRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRG 191
+L DL N++ E FP+ L+ + HNN + +P AF G
Sbjct: 223 QHLGTHSFEGLHNLETLDLNYNKLQE-FPVAIRTLGRLQELGFHNNNIK--AIPEKAFMG 279
Query: 192 SEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLT 251
+ P L+ +H +N I V R A +L L L
Sbjct: 280 N---------------------PLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL------ 312
Query: 252 DSGLDATTFSKLH---SLEYLDLSHNQLTTVPAG----LPRTLAILHLGRNRIRQVEAAR 304
+ +D F L SLE L L+ + +P+G LPR L +L L N+I ++ +
Sbjct: 313 NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELPS-- 369
Query: 305 LHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV-- 362
LH + L + LQHN++ G A L L L L N + + P L +LV
Sbjct: 370 LHRCQKLEEIGLQHNRIWEIG--ADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 427
Query: 363 -LPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRAL 408
L N + L L GL L L N S +F +LR L
Sbjct: 428 DLTDNQLTTL---PLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRIL 471
Score = 75.9 bits (185), Expect = 8e-14
Identities = 70/206 (33%), Positives = 97/206 (47%), Gaps = 14/206 (6%)
Query: 268 YLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSS 324
YLDLS N LT + GL R L L L N + + G L+ L+LQ+NQLG
Sbjct: 70 YLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG-- 127
Query: 325 GLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATPG 381
G+PA AL L L +L L N + VP LR L L N + + R L P
Sbjct: 128 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 187
Query: 382 LTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTG---LRTLQLQRNQ 438
L + LA NR+ + + AF+ L +L L L N++ L G L TL L N+
Sbjct: 188 LQAMTLALNRI--SHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK 245
Query: 439 LRMLEPEPLAGLDQLRELSLAHNRLR 464
L+ P + L +L+EL +N ++
Sbjct: 246 LQEF-PVAIRTLGRLQELGFHNNNIK 270
Score = 44.3 bits (103), Expect = 3e-04
Identities = 55/220 (25%), Positives = 97/220 (44%), Gaps = 35/220 (15%)
Query: 51 PRVDTVDCDG-LDLRVFPD-NITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLI 108
P++ T+ +G +D++ FPD T + + L+L ++ LP +L LR L L +N I
Sbjct: 305 PKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 364
Query: 109 SSEGLPDEAFESLTQLQHLCVAHNKL-SVAPQFLPR--SLRVADLAANQVMEIFPLTFGE 165
E LP + +L+ + + HN++ + + SL+ DL+ N + I P F
Sbjct: 365 --EELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 420
Query: 166 KPALRSVYLHNNQLSN------AGLPPDAFRGSEAIATLSLSNN-------QLSYLPPSL 212
+L + L +NQL+ GL +G+ A++ ++ ++ Y
Sbjct: 421 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC 480
Query: 213 PPSL-------------ERLHLQNNLISKVPRGALSRQTQ 239
P + E LHL + SK P G L+RQ +
Sbjct: 481 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAE 520
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 119 bits (298), Expect = 7e-27
Identities = 124/436 (28%), Positives = 188/436 (43%), Gaps = 50/436 (11%)
Query: 40 LPRACPLRCSCP----RVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRL 95
L R CP C C + VDC L L P N++ +L L N + +L N L L
Sbjct: 30 LLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSL 89
Query: 96 SGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAP----QFLPRSLRVADLA 151
L L L N ++ +P AF L L+ L + +N+L P Q L RSL+ L
Sbjct: 90 RFLEELRLAGNALTY--IPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNL-RSLQSLRLD 146
Query: 152 ANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPP- 210
AN + + P F +LR ++L +N L+ +P AFR A+ ++L+ N++ ++P
Sbjct: 147 ANHISYVPPSCFSGLHSLRHLWLDDNALTE--IPVQAFRSLSALQAMTLALNKIHHIPDY 204
Query: 211 --SLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEY 268
SL LHL NN I + + L L L +N L + T L +L+
Sbjct: 205 AFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF---PTAIRTLSNLKE 261
Query: 269 LDLSHNQLTTVP----AGLPRTLA-------ILHLGRNRIRQVEAAR------------- 304
L N + ++P G P + I +GR+ + + R
Sbjct: 262 LGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEF 321
Query: 305 --LHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPP-ALPRRLRAL 361
L G L L L Q+ S LP L L L L N L+ +P ++ ++L+ +
Sbjct: 322 PDLTGTANLESLTLTGAQI--SSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKI 379
Query: 362 VLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRL 421
L HN + + L LNLA+N++A +H AF L +L LDL+ N L+
Sbjct: 380 DLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAI--IHPNAFSTLPSLIKLDLSSNLLSSF 437
Query: 422 PMGLPTGLRTLQLQRN 437
P+ GL L+L N
Sbjct: 438 PITGLHGLTHLKLTGN 453
Score = 92.8 bits (229), Expect = 7e-19
Identities = 102/357 (28%), Positives = 151/357 (42%), Gaps = 22/357 (6%)
Query: 134 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 193
LS P L DL+ N + ++ P L + L N L+ +P AF G
Sbjct: 57 LSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTY--IPKGAFTGLY 114
Query: 194 AIATLSLSNNQLSYLPPSLPP---SLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQL 250
++ L L NNQL ++P SL+ L L N IS VP S LR L+L N L
Sbjct: 115 SLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNAL 174
Query: 251 TDSGLDATTFSKLHSLEYLDLSHNQLTTVPA---GLPRTLAILHLGRNRIRQVEAARLHG 307
T+ + A F L +L+ + L+ N++ +P G +L +LHL NRI + G
Sbjct: 175 TEIPVQA--FRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDG 232
Query: 308 ARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPH-- 365
L L L +N L P A+R L L L + N + +P +L+ H
Sbjct: 233 LHSLETLDLNYNNLDE--FPT-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFY 289
Query: 366 -NHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMG 424
N + +G P L L L AS L SL L G Q++ LP
Sbjct: 290 DNPIQFVGRSAFQHLPELRTLTL---NGASQITEFPDLTGTANLESLTLTGAQISSLPQT 346
Query: 425 LPTGLRTLQLQRNQLRMLEPEPLAGLDQ-LRELSLAHNRLRVGDIGPGTWHELQALQ 480
+ L LQ+ +LE P + Q L+++ L HN + +I T+ +L +L+
Sbjct: 347 VCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHN--EIYEIKVDTFQQLLSLR 401
Score = 35.0 bits (79), Expect = 0.16
Identities = 28/89 (31%), Positives = 38/89 (42%), Gaps = 1/89 (1%)
Query: 406 RALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 465
R L +D + L+ LP L L L N + L P PL L L EL LA N L
Sbjct: 45 RMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTY 104
Query: 466 GDIGPGT-WHELQALQVRHRLVSHTVPRA 493
G T + L+ L +++ + H A
Sbjct: 105 IPKGAFTGLYSLKVLMLQNNQLRHVPTEA 133
>gi|4502403 biglycan preproprotein [Homo sapiens]
Length = 368
Score = 117 bits (293), Expect = 2e-26
Identities = 85/259 (32%), Positives = 130/259 (50%), Gaps = 8/259 (3%)
Query: 44 CPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNL 103
CP C C + V C L L+ P I+ L LQNN + EL ++ L L L L
Sbjct: 63 CPFGCHC-HLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVL 121
Query: 104 HNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTF 163
NN IS + ++AF L +LQ L ++ N L P LP SL + N++ ++ F
Sbjct: 122 VNNKISK--IHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVF 179
Query: 164 GEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQN 223
+ + + N L N+G P AF G + + L +S +L+ +P LP +L LHL +
Sbjct: 180 SGLRNMNCIEMGGNPLENSGFEPGAFDGLK-LNYLRISEAKLTGIPKDLPETLNELHLDH 238
Query: 224 NLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGL 283
N I + L R ++L L L HNQ+ ++ + S L +L L L +N+L VP+GL
Sbjct: 239 NKIQAIELEDLLRYSKLYRLGLGHNQI--RMIENGSLSFLPTLRELHLDNNKLARVPSGL 296
Query: 284 P--RTLAILHLGRNRIRQV 300
P + L +++L N I +V
Sbjct: 297 PDLKLLQVVYLHSNNITKV 315
Score = 107 bits (268), Expect = 2e-23
Identities = 81/244 (33%), Positives = 118/244 (48%), Gaps = 7/244 (2%)
Query: 134 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 193
L P+ + + DL N + E+ F L ++ L NN++S + AF
Sbjct: 81 LKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISK--IHEKAFSPLR 138
Query: 194 AIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 253
+ L +S N L +PP+LP SL L + +N I KVP+G S + + + N L +S
Sbjct: 139 KLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENS 198
Query: 254 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 313
G + F L L YL +S +LT +P LP TL LHL N+I+ +E L L
Sbjct: 199 GFEPGAFDGL-KLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYR 257
Query: 314 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALP--RRLRALVLPHNHVAAL 371
L L HNQ+ + G+L L L LHL N L RVP LP + L+ + L N++ +
Sbjct: 258 LGLGHNQIRM--IENGSLSFLPTLRELHLDNNKLARVPSGLPDLKLLQVVYLHSNNITKV 315
Query: 372 GARD 375
G D
Sbjct: 316 GVND 319
Score = 100 bits (249), Expect = 3e-21
Identities = 76/240 (31%), Positives = 115/240 (47%), Gaps = 6/240 (2%)
Query: 195 IATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSG 254
+ + S+ L +P + P L LQNN IS++ + L L L +N++ S
Sbjct: 71 LRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKI--SK 128
Query: 255 LDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYL 314
+ FS L L+ L +S N L +P LP +L L + NRIR+V G R + +
Sbjct: 129 IHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCI 188
Query: 315 LLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGAR 374
+ N L +SG GA L+ L+ L + L +P LP L L L HN + A+
Sbjct: 189 EMGGNPLENSGFEPGAFDGLK-LNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELE 247
Query: 375 DLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQL 434
DL+ L L L +N++ + + + L LR L L N+L R+P GLP L+ LQ+
Sbjct: 248 DLLRYSKLYRLGLGHNQI--RMIENGSLSFLPTLRELHLDNNKLARVPSGLP-DLKLLQV 304
Score = 55.5 bits (132), Expect = 1e-07
Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 2/137 (1%)
Query: 346 GLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRL 405
GL VP + L L +N ++ L D L L L N+++ ++H +AF L
Sbjct: 80 GLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKIS--KIHEKAFSPL 137
Query: 406 RALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 465
R L+ L ++ N L +P LP+ L L++ N++R + +GL + + + N L
Sbjct: 138 RKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLEN 197
Query: 466 GDIGPGTWHELQALQVR 482
PG + L+ +R
Sbjct: 198 SGFEPGAFDGLKLNYLR 214
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 113 bits (283), Expect = 4e-25
Identities = 104/351 (29%), Positives = 165/351 (47%), Gaps = 46/351 (13%)
Query: 1 MGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDG 60
MG +WP G P +A + A + + L L ACP +C C ++ CD
Sbjct: 1 MGLHFKWPL--------GAPMLAAIY--AMSMVLKMLPALGMACPPKCRCEKL-LFYCDS 49
Query: 61 LDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFES 120
P+ + + LSL++N + EL ++ + S L L+L +N IS+ + ++AF+
Sbjct: 50 QGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQIST--VKEDAFQG 107
Query: 121 LTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLS 180
L +L+ L ++ NK+ P TF + L+++ L NQLS
Sbjct: 108 LYKLKELILSSNKIFYLPN---------------------TTFTQLINLQNLDLSFNQLS 146
Query: 181 NAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLERLHLQNNLISKVPRGALSRQ 237
+ L P+ F G + TL L +N L +P L SLE L L N + + R +
Sbjct: 147 S--LHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGL 204
Query: 238 TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLP---RTLAILHLGR 294
+LREL+L+HNQLT ++ F +L SL L L N+++ + G+ TL L L
Sbjct: 205 IKLRELHLEHNQLTK--INFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTG 262
Query: 295 NRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGN 345
N I+ ++ L+ LL+ +N+L S L + L LR L T+ L GN
Sbjct: 263 NEIKAIDLTVFETMPNLKILLMDNNKLNS--LDSKILNSLRSLTTVGLSGN 311
Score = 68.9 bits (167), Expect = 1e-11
Identities = 76/273 (27%), Positives = 118/273 (43%), Gaps = 36/273 (13%)
Query: 198 LSLSNNQLSYLPPSLPPSLERL---HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSG 254
LSL +N ++ L S +L HL +N IS V A +L+EL L N++
Sbjct: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFY-- 123
Query: 255 LDATTFSKLHSLEYLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGL 311
L TTF++L +L+ LDLS NQL+++ L R L LHL N +R + R L
Sbjct: 124 LPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSL 183
Query: 312 RYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAAL 371
+L L N+L S L NG + +LR L L HN + +
Sbjct: 184 EFLDLSTNRLRS------------------LARNGFAGLI-----KLRELHLEHNQLTKI 220
Query: 372 GARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGL---PTG 428
+ L L L +N++++ L LDL GN++ + + +
Sbjct: 221 NFAHFLRLSSLHTLFLQWNKISNLTCGME--WTWGTLEKLDLTGNEIKAIDLTVFETMPN 278
Query: 429 LRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHN 461
L+ L + N+L L+ + L L L + L+ N
Sbjct: 279 LKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
Score = 61.6 bits (148), Expect = 2e-09
Identities = 56/189 (29%), Positives = 85/189 (44%), Gaps = 28/189 (14%)
Query: 278 TVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGL 337
+VP + L L N I ++E + L +L L HNQ+ + A +GL
Sbjct: 54 SVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDA-----FQGL 108
Query: 338 HTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARV 397
+ +L+ L+L N + L L L+L++N+L+S +
Sbjct: 109 Y------------------KLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSS--L 148
Query: 398 HHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ---LQRNQLRMLEPEPLAGLDQLR 454
H F LR L++L L N L +P+ L R+L+ L N+LR L AGL +LR
Sbjct: 149 HPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLR 208
Query: 455 ELSLAHNRL 463
EL L HN+L
Sbjct: 209 ELHLEHNQL 217
Score = 56.2 bits (134), Expect = 7e-08
Identities = 43/122 (35%), Positives = 60/122 (49%), Gaps = 5/122 (4%)
Query: 346 GLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRL 405
G VP A + L L HNH+ L + LT L+L +N++++ V AF+ L
Sbjct: 51 GFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQIST--VKEDAFQGL 108
Query: 406 RALRSLDLAGNQLTRLPMGLPT---GLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNR 462
L+ L L+ N++ LP T L+ L L NQL L PE GL +L+ L L N
Sbjct: 109 YKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNS 168
Query: 463 LR 464
LR
Sbjct: 169 LR 170
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 113 bits (283), Expect = 4e-25
Identities = 129/476 (27%), Positives = 192/476 (40%), Gaps = 91/476 (19%)
Query: 41 PRACPLRCSCPRVDTVDCDGLDLRVFPD--------------NITRAAQH---------- 76
P C CSC VDC G L P+ NIT+ +
Sbjct: 26 PPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEE 85
Query: 77 ------------------------LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEG 112
L+LQNNQL+ +P + LS L++L L N I+S
Sbjct: 86 LQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITS-- 143
Query: 113 LPDEAFESLTQLQHLCVAHNKLSVAP----QFLPRSLRVADLAANQVMEIFPLTFGEKPA 168
+P+++FE L QL+HL + N L+ P LP +L+ LA N++ I F +
Sbjct: 144 VPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLP-TLQALTLALNKISSIPDFAFTNLSS 202
Query: 169 LRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLP--PSLERLHLQNNLI 226
L ++LHNN++ + L F G + + TL L+ N L P ++ PSL+ L +N I
Sbjct: 203 LVVLHLHNNKIRS--LSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSI 260
Query: 227 SKVPRGALSRQTQLRELYLQHNQLTDSGLDA-TTFSKLHSLEYLDLSHNQLTTVPAGLPR 285
S +P GA LR ++L N L+ G A S LHSL S Q P
Sbjct: 261 SVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQ------QFPN 314
Query: 286 TLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGN 345
+HL E+ L G + S +P + + L TL L N
Sbjct: 315 LTGTVHL--------ESLTLTGTK-------------ISSIPNNLCQEQKMLRTLDLSYN 353
Query: 346 GLDRVPPALP-RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRR 404
+ +P L + L N + + L L+L+ N + +H RAF
Sbjct: 354 NIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLI--HEIHSRAFAT 411
Query: 405 LRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAH 460
L + +LD++ N+LT P GL L+L N ++ E LR LS+ +
Sbjct: 412 LGPITNLDVSFNELTSFPTEGLNGLNQLKLVGN-FKLKEALAAKDFVNLRSLSVPY 466
Score = 44.3 bits (103), Expect = 3e-04
Identities = 45/150 (30%), Positives = 62/150 (41%), Gaps = 31/150 (20%)
Query: 321 LGSSGLPAGALRPL-------RGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGA 373
LGS+G P+GA PL G + G GL VP L +AL + N++ L
Sbjct: 16 LGSAG-PSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPE 74
Query: 374 RDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ 433
P L EL LA N L+ +H +A L+ L+ L
Sbjct: 75 DAFKNFPFLEELQLAGNDLSF--IHPKALSGLKELK---------------------VLT 111
Query: 434 LQRNQLRMLEPEPLAGLDQLRELSLAHNRL 463
LQ NQL+ + E + GL L+ L L N +
Sbjct: 112 LQNNQLKTVPSEAIRGLSALQSLRLDANHI 141
Score = 38.1 bits (87), Expect = 0.019
Identities = 21/59 (35%), Positives = 36/59 (61%), Gaps = 3/59 (5%)
Query: 409 RSLDLAGNQLTRLPMGLPTG---LRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLR 464
++LD++ N +T+LP L LQL N L + P+ L+GL +L+ L+L +N+L+
Sbjct: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLK 118
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 113 bits (282), Expect = 5e-25
Identities = 96/279 (34%), Positives = 134/279 (48%), Gaps = 35/279 (12%)
Query: 73 AAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHN 132
A + L LQ NQLQ LP L+ L+TLNL NL++ LP+E F LT LQ L +++N
Sbjct: 146 ALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQ--LPEELFHPLTSLQTLKLSNN 203
Query: 133 KLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGS 192
LS PQ + FG+ +L+ ++L +N +S LPP F
Sbjct: 204 ALSGLPQGV---------------------FGKLGSLQELFLDSNNISE--LPPQVFSQL 240
Query: 193 EAIATLSLSNNQLSYLPPSLPPSLER---LHLQNNLISKVPRGALSRQTQLRELYLQHNQ 249
+ L L N +++LP S+ SL L LQ N++ +P G + L L L HNQ
Sbjct: 241 FCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQ 300
Query: 250 LTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPR---TLAILHLGRNRIRQVEAARLH 306
L + TF+ L +L L LS+N +T +PAG+ R L L+LG N + + A
Sbjct: 301 L--ETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQ 358
Query: 307 GARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGN 345
L L L NQL + LP G L L L+GN
Sbjct: 359 NLSKLELLSLSKNQL--TTLPEGIFDTNYNLFNLALHGN 395
Score = 99.0 bits (245), Expect = 9e-21
Identities = 109/391 (27%), Positives = 164/391 (41%), Gaps = 41/391 (10%)
Query: 44 CPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNL 103
CP+ C C V V C +L P +I +++ L L +
Sbjct: 22 CPMGCDC-FVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVF 80
Query: 104 HNNLISSEGLPDEAFESLTQLQHLCVAHNK-LSVAPQFLPRSLRVADLAAN-QVMEIFPL 161
N + +AF L +L+ L V + L+++ + L N ++E P
Sbjct: 81 LNTQLCQ--FRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPE 138
Query: 162 -TFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLE 217
F AL S++L NQL LP F+ + TL+L+ N L+ LP L SL+
Sbjct: 139 GLFQHLAALESLHLQGNQLQ--ALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQ 196
Query: 218 RLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLT 277
L L NN +S +P+G + L+EL+L N +++ L FS+L LE L L N +T
Sbjct: 197 TLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISE--LPPQVFSQLFCLERLWLQRNAIT 254
Query: 278 TVPAGLPRTLA---ILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPL 334
+P + +L L L N +R + A L L L HNQL + + G L
Sbjct: 255 HLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLET--VAEGTFAHL 312
Query: 335 RGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLAS 394
L +L L N + +P + R L LV + LG+ +L A
Sbjct: 313 SNLRSLMLSYNAITHLPAGIFRDLEELVKLY-----LGSNNLTA---------------- 351
Query: 395 ARVHHRAFRRLRALRSLDLAGNQLTRLPMGL 425
+H F+ L L L L+ NQLT LP G+
Sbjct: 352 --LHPALFQNLSKLELLSLSKNQLTTLPEGI 380
Score = 92.0 bits (227), Expect = 1e-18
Identities = 102/352 (28%), Positives = 144/352 (40%), Gaps = 20/352 (5%)
Query: 124 LQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAG 183
+Q + + +L+ P +P + + FG P L V N QL
Sbjct: 30 VQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQ-- 87
Query: 184 LPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLERLHLQNNLISKVPRGALSRQTQL 240
PDAF G + L ++ + L ++ SL +L L N++ +P G L
Sbjct: 88 FRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAAL 147
Query: 241 RELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGL--PRT-LAILHLGRNRI 297
L+LQ NQL L F L L+ L+L+ N L +P L P T L L L N +
Sbjct: 148 ESLHLQGNQL--QALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNAL 205
Query: 298 RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPAL--- 354
+ L+ L L N + S LP L L L L N + +P ++
Sbjct: 206 SGLPQGVFGKLGSLQELFLDSNNI--SELPPQVFSQLFCLERLWLQRNAITHLPLSIFAS 263
Query: 355 PRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLA 414
L L L N + L A TP L L+L +N+L + V F L LRSL L+
Sbjct: 264 LGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLET--VAEGTFAHLSNLRSLMLS 321
Query: 415 GNQLTRLPMGLPTGLR---TLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRL 463
N +T LP G+ L L L N L L P L +L LSL+ N+L
Sbjct: 322 YNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQL 373
Score = 57.8 bits (138), Expect = 2e-08
Identities = 76/275 (27%), Positives = 112/275 (40%), Gaps = 41/275 (14%)
Query: 201 SNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTF 260
S+ +L+ +P +PP + + + + A L ++ + QL DA F
Sbjct: 36 SDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDA--F 93
Query: 261 SKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQ 320
L LE L+++ + + L+L N + + L L L N
Sbjct: 94 GGLPRLEDLEVTGS-------------SFLNLSTNIFSNLTS--------LGKLTLNFNM 132
Query: 321 LGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRL-------RALVLPHNHVAALGA 373
L LP G + L L +LHL GN L ALPRRL + L L N +A L
Sbjct: 133 L--EALPEGLFQHLAALESLHLQGNQLQ----ALPRRLFQPLTHLKTLNLAQNLLAQLPE 186
Query: 374 RDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ 433
L L L+ N L+ + F +L +L+ L L N ++ LP + + L L+
Sbjct: 187 ELFHPLTSLQTLKLSNNALSG--LPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLE 244
Query: 434 ---LQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 465
LQRN + L A L L LSL N LRV
Sbjct: 245 RLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRV 279
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,845,899
Number of Sequences: 37866
Number of extensions: 993216
Number of successful extensions: 7046
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 174
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 3118
Number of HSP's gapped (non-prelim): 1470
length of query: 510
length of database: 18,247,518
effective HSP length: 107
effective length of query: 403
effective length of database: 14,195,856
effective search space: 5720929968
effective search space used: 5720929968
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.